LOCUS       DAVLHC010000001       104457 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.001, whole genome shotgun sequence.
ACCESSION   DAVLHC010000001 DAVLHC010000000
VERSION     DAVLHC010000001.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 104457)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 104457)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..104457
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.001"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(256..1818)
                     /gene="guaA"
                     /locus_tag="VXE25_000001"
     CDS             complement(256..1818)
                     /gene="guaA"
                     /locus_tag="VXE25_000001"
                     /EC_number="6.3.5.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000065723.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine-hydrolyzing GMP synthase"
                     /protein_id="HEV0770547.1"
                     /translation="MSNISTDLQDVEKIIVLDYGSQYNQLISRRIREIGVFSELKSHK
                     ISAAEVREVNPVGIILSGGPNSVYEDGSFDIDPEIFELGIPILGICYGMQLLTHKLGG
                     KVVPAGDAGNREYGQSTLTHTPSALFESTPDEQTVLMSHGDAVTEIPADFVRTGTSAD
                     CPYAAIENPDKHIYGIQFHPEVRHSVYGNDILRNFALNICKAKGDWSMDNFIDMQIKK
                     IRETVGDKRVLLGLSGGVDSSVVGVLLQKAIGDQLICIFVDHGLLRKGEADQVMDMLG
                     GKFGLNIVKADAAKRFLDKLAGVSDPEQKRKIIGNEFVYVFDDEASKLKDVKFLAQGT
                     LYTDVIESGTDTAQTIKSHHNVGGLPEDMQFELIEPLNTLYKDEVRALGTELGMPDHI
                     VWRQPFPGPGLAIRVMGEITEEKLETVRESDAILREEIAKAGLDRDIWQYFTVNTGVR
                     SVGVMGDGRTYDYTIAIRAITSIDGMTADFAKIPWEVLQKISVRIVNEVDHVNRIVYD
                     ITSKPPATVEWE"
     gene            1960..2658
                     /locus_tag="VXE25_000002"
     CDS             1960..2658
                     /locus_tag="VXE25_000002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000936186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HEV0770548.1"
                     /translation="MLPAYMKIHDQIKKDIDEHRWAIGERLPSERDLAEQFAVSRMTL
                     RQAVSLLVEEGVLERRVGSGTFVSSTRVQEKMRGTTSFTEIVKSQGKVPSSQLISYKK
                     TIPNEQEVAKLGIFPTDNIIRMERVRYADQVPLVYEVASIPEKFIKDFKKEEITSHFF
                     QTLQKHGYRIGKSQQTIYARLAKEKIAHYLEVEKGHAILGLTQISYLEDGTAFEYVKS
                     QYVGERFEFYLENN"
     gene            complement(2701..3597)
                     /locus_tag="VXE25_000003"
     CDS             complement(2701..3597)
                     /locus_tag="VXE25_000003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000071673.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EamA family transporter"
                     /protein_id="HEV0770549.1"
                     /translation="MSNSLKGTLLTVVAGIAWGLSGTSGQYLMAHGISALVLTNLRLL
                     IAGGILMLLAYATAKDKILVFLKDRKSLLSLLIFALIGLFLNQFAYLSAIQETNAGTA
                     TVLQYVCPVGILIYSCIKDRVAPTLGEIVSIIFAIGGTFLIATHGQLDQLSMTPAGLF
                     WGLFSALTYALYIILPIALIKKWGSSLVIGVGMVIAGLVALPFTGVLQADIPTSLDFL
                     LAFAGIILIGTVFAYTAFLKGASLIGPVKSSLLASIEPISAIFFAFLIMNEQFYPIDF
                     LGMAMILFAVTLISLKDLFLEK"
     gene            complement(3606..4541)
                     /locus_tag="VXE25_000004"
     CDS             complement(3606..4541)
                     /locus_tag="VXE25_000004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000872223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-lactamase family protein"
                     /protein_id="HEV0770550.1"
                     /translation="MKWTKIIKKIEEQIEAGIYPGASFAYFKDNQWTEFYLGQSDPEH
                     GLQTEAGLVYDLASVSKVVGVGTVCTFLWEIGQLDIDRLVIDFLPESDYPDITIRQLL
                     THATDLDPFIPNRDLLTAPELKEAMFHLNRRSQPAFLYSDVHFLLLGFILERIFNQDL
                     DVILKDQVWKPWGMTETKFGPVELAVPTVRGVEAGIVHDPKARLLGRHAGSAGLFSTI
                     KDLQIFLEHYLADDFARDLNQNFSPLDDKERSLAWNLEGDWLDHTGYTGTFIMWNRQK
                     QEATIFLSNRTYEKDERAQWILDRNQVMNLIRKEE"
     gene            complement(4538..5263)
                     /locus_tag="VXE25_000005"
     CDS             complement(4538..5263)
                     /locus_tag="VXE25_000005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001102210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CppA family protein"
                     /protein_id="HEV0770551.1"
                     /translation="MNVNQIVRIIPTLKANNRKLNETFYIETLGMKALLEESAFLSLG
                     DQTGLEKLVLEEAPSMRTRKVEGRKKLARLIVKVENPLEIEGILSKTDSIHRLYKGQN
                     GYAFEIFSPEDDLILIHAEDDIASLVEVGEKPEFQTDLASISLSKFEISMELHLPTDI
                     ESFLESSEIGASLDFIPAQGQDLTVDNTVTWDLSMLKFLVNELDIASLRQKFESTEYF
                     IPKSEKFFLGKDRNNVELWFEEV"
     gene            complement(5347..5982)
                     /locus_tag="VXE25_000006"
     CDS             complement(5347..5982)
                     /locus_tag="VXE25_000006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000290646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-alkyl-2-acetylglycerophosphocholine esterase"
                     /protein_id="HEV0770552.1"
                     /translation="MAVQLLENWLLKEQEKIQTKYRHLNHISVVEPNILFIGDSIVEY
                     YPLQELFGTSKTIVNRGIRGYQTGLLLENLDAHLYGGAVDKIFLLIGTNDIGKDVPVN
                     EALNNLEAIIQSVARDYPLTEIKLLSILPVNEREEYQQAVYIRSNEKIQNWNQAYQEL
                     ASAYMQVEFVPVFDCLTDQAGQLKKEYTTDGLHLSIAGYQALSKSLKDYLY"
     gene            complement(5984..6811)
                     /locus_tag="VXE25_000007"
     CDS             complement(5984..6811)
                     /locus_tag="VXE25_000007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEV0770553.1"
                     /translation="MMIKVIATDMDGTLLDARGQLDLPRLEKILDQLDQRGIRFVIAT
                     GNEIHRMRQLLSPLVDRVVLVVANGARIFENNELIQAQTWDDAIVNKALTHFKGRACQ
                     DQFVVTGMKGDFVKEGTIFTDLESFMTPEMIEKFYQRMQFVDELTSDLFGGVLKMSMV
                     VGEERLSSVLEEINALFDGRVRAVSSGYGCIDILQAGIHKAWGLEELLKRWDLKSQEI
                     MAFGDSENDVEMLEMAGIAYAMENADEKAKAVATALAPANSQGGVYQVLENWLEKGE"
     gene            complement(6833..7759)
                     /locus_tag="VXE25_000008"
                     /pseudo
     CDS             complement(6833..7759)
                     /locus_tag="VXE25_000008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809127.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="CapA family protein"
     gene            8410..9021
                     /locus_tag="VXE25_000009"
     CDS             8410..9021
                     /locus_tag="VXE25_000009"
                     /EC_number="3.5.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015058782.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide deformylase"
                     /protein_id="HEV0770554.1"
                     /translation="MSAIERITKAAHLIDMNDIIREGNPTLRTVAEEVTFPLSDQEII
                     LGEKMMQFLKHSQDPVMAEKMGLRGGVGLAAPQLDISKRIIAVLVPNIVEEGETPQEA
                     YDLEAIMYNPKIVSHSVQDAALGEGEGCLSVDRNVPGYVVRHARVTVDYFDKDGEKHR
                     IKLKGYNSIVVQHEIDHINGIMFYDRINEKDPFAVKDGLLILE"
     gene            9066..9794
                     /gene="rlmB"
                     /locus_tag="VXE25_000010"
     CDS             9066..9794
                     /gene="rlmB"
                     /locus_tag="VXE25_000010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151108.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA
                     (guanosine(2251)-2'-O)-methyltransferase RlmB"
                     /protein_id="HEV0770555.1"
                     /translation="MKTNDIVYGVHAVTEALLANTGNKLYLQEDLRGKNVEKVKELAT
                     EKKVSISWTSKKSLSEMTEGAVHQGFVLRVSEFAYSELDYILAKTRQEENPLLLILDG
                     LTDPHNLGSILRTADATNVSGVIIPKHRAVGVTPVVAKTATGAIEHVPIARVTNLSQT
                     LDKLKDEGFWTFGTDMNGTPCHKWNTKGKIALIIGNEGKGISSNIKKQVDEMITIPMN
                     GHVQSLNASVAAAILMYEVFRNRL"
     gene            complement(9833..10744)
                     /gene="trxB"
                     /locus_tag="VXE25_000011"
     CDS             complement(9833..10744)
                     /gene="trxB"
                     /locus_tag="VXE25_000011"
                     /EC_number="1.8.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin-disulfide reductase"
                     /protein_id="HEV0770556.1"
                     /translation="MYDTIIIGAGPAGMTAALYAARSNLKVALIEGGLPGGQMNNTSD
                     IENYPGYANISGPELAEKMFEPLENLGVEHIYGYVENVEDHGDFKKVMTDDQTYETRT
                     VIVATGSKHRPLGVPGEEELNSRGVSYCAVCDGAFFRDQDLLIVGGGDSAVEEALFLT
                     RFAKTVTIVHRRDQLRAQKVLQDRAFANEKISFIWDSVVREIKGENRVESVVFENVKT
                     GQVTEQAFGGVFIYVGLDPLSDFVKELNIQDQAGWIVTDSHMKTAVDGIFAVGDVRLK
                     DLRQVTTAVGDGAIAGQEAYKFITEHS"
     gene            complement(10810..11034)
                     /locus_tag="VXE25_000012"
     CDS             complement(10810..11034)
                     /locus_tag="VXE25_000012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000924294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4059 family protein"
                     /protein_id="HEV0770557.1"
                     /translation="MLLQLFSLYFESLILTTILVLIFLGIWIGLRAMSGVDKTAKARQ
                     AHLYDMIMIGVLVVPVLSFAVMSLILVFKA"
     gene            complement(11112..11855)
                     /locus_tag="VXE25_000013"
     CDS             complement(11112..11855)
                     /locus_tag="VXE25_000013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEV0770558.1"
                     /translation="MIKISNLSKSFSGQTVLDHLDLDIQKGEVVALIGSSGAGKSTFL
                     RSLNYLETPDSGSIQIDGFSVDFSKITQEEILALRRKLSMVFQQFNLFERRTALDNVK
                     EGLVVVKKLSDQEATKIAKEELAKVGLSDRENHYPRHLSGGQKQRVALARALAMKPDV
                     LLLDEPTSALDPELVGEVEKSIADAAKSGQTMILVSHDMSFVAQVADKILFLDKGKII
                     ESGTPDEIIHTPKEERTKEFFASYKRTYI"
     gene            complement(11855..12655)
                     /locus_tag="VXE25_000014"
     CDS             complement(11855..12655)
                     /locus_tag="VXE25_000014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001103446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEV0770559.1"
                     /translation="MNVTTILASDWYQNLMQLIPDGKLFSLRSVFDGIPRIVQQLPTT
                     IMLTIGGALFGLVLALLFAIVKINRVKILYPLQAFFVSFLKGTPILVQLMLTYYGIPL
                     ALKALNQQWGTGLNINAIPAAAFAIVAFAFNEAAYASETIRAAILSVNPGEIEAARSL
                     GMTRAQVYRRVIIPNAAVVATPTLINSLIGLTKGTSLAFSAGVVEVFAQAQILGGADY
                     RYFERFISVALVYWVVNIGIESLGRFIERKMAISAPDTVQTDVKGDLR"
     gene            complement(12813..13169)
                     /locus_tag="VXE25_000015"
     CDS             complement(12813..13169)
                     /locus_tag="VXE25_000015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000889075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arsenate reductase family protein"
                     /protein_id="HEV0770560.1"
                     /translation="MLEFIEYPKCSTCKKAKQELNQLGVDYKAVHIVEETPSQEVILN
                     WLETSGFELKQFFNTSGIKYRELGLKDKVGSLSNQEAAELLASDGMLLKRPILVENGT
                     VKQIGYRKSYEELGLK"
     gene            complement(13182..13694)
                     /locus_tag="VXE25_000016"
     CDS             complement(13182..13694)
                     /locus_tag="VXE25_000016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001170346.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylated-DNA--[protein]-cysteine
                     S-methyltransferase"
                     /protein_id="HEV0770561.1"
                     /translation="MQKKYVKILYSSPIGILSLVADDHYLYGIWVQEQKHFERGLGDE
                     TIEEVVSHPILDPVIACLDDYFKGKPQDLSNLLLAPIGTNFEKRVWDYLQGIPYGQTV
                     TYGQIAQDLQVASAQAIGGAVGRNPWSILVPCHRVLGAGKRLTGYAAGVEKKAWLLEH
                     EGVDFKDINK"
     gene            complement(13694..14188)
                     /locus_tag="VXE25_000017"
     CDS             complement(13694..14188)
                     /locus_tag="VXE25_000017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0770562.1"
                     /translation="MEIRLAFPNEVDAIMQVMEDAKKCLADAGSDQWQNGYPNADVII
                     DDIISGQAYVALEEGELLAYAAVTKSPEEAYEAIYEGNWQAGESEYLVFHRIAVAADV
                     QGKGVAQTFLEGLIEGFDYLDFRSDTHAENKVMQHIFEKLGFKQVGKVPVDGERLAYQ
                     KLKK"
     gene            14323..14769
                     /locus_tag="VXE25_000018"
     CDS             14323..14769
                     /locus_tag="VXE25_000018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000858725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1836 domain-containing protein"
                     /protein_id="HEV0770563.1"
                     /translation="MKTTFSYPKWAEIPNIDLYLDQVLLYVNQVCAPISPNKDKGLTA
                     SMVNNYVKNGYLTKPDKKKYQRQQIARLIAITTLKSVFSIQEIAQTLNTLQTQASSDQ
                     LYDAFVDYMNQGIDPANPIIQTSCQTVKLYHQTLDLIDHTQEEVIQ"
     gene            14766..15413
                     /locus_tag="VXE25_000019"
     CDS             14766..15413
                     /locus_tag="VXE25_000019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001097995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hemolysin III family protein"
                     /protein_id="HEV0770564.1"
                     /translation="MNTSLKLSKQLSFGEEIANSVTHAVGAVIMLILLPISSIYSYEA
                     HGFLSSIGVSIFVISLFLMFLSSTIYHSMAYGSTHKYVLRIIDHSMIYVAIAGSYTPV
                     VLTLMNNWFGYLIIVIQWGTTIFGILYKIFAKKVNEKFSLALYLIMGWLVLVIIPAII
                     SQTTPVFWSLMVTGGLCYTVGAGFYAKKKPYFHMIWHLFILAASALQYIAIVYYM"
     gene            complement(15434..16015)
                     /gene="pdxT"
                     /locus_tag="VXE25_000020"
     CDS             complement(15434..16015)
                     /gene="pdxT"
                     /locus_tag="VXE25_000020"
                     /EC_number="3.5.1.2"
                     /EC_number="4.3.3.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000689933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal 5'-phosphate synthase glutaminase
                     subunit PdxT"
                     /protein_id="HEV0770565.1"
                     /translation="MKIGILALQGAFAEHAKVLDQLGVESVELRNLDDFQQDQSDLSG
                     LILPGGESTTMGKLLRDQNMLLPIREAILSGLPVFGTCAGLILLAKEITSQKESHLGT
                     MDMVVERNAYGRQLGSFYTEAECKGVGKIPMTFIRGPIISSVGEGVEILATVNNQIVA
                     AQEKNMLVSSFHPELTDDVRLHQYFINMCKEKS"
     gene            complement(16016..16891)
                     /gene="pdxS"
                     /locus_tag="VXE25_000021"
     CDS             complement(16016..16891)
                     /gene="pdxS"
                     /locus_tag="VXE25_000021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012054698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal 5'-phosphate synthase lyase subunit
                     PdxS"
                     /protein_id="HEV0770566.1"
                     /translation="MTENRYELNKNLAQMLKGGVIMDVQNPEQARIAEAAGAAAVMAL
                     ERIPADIRAAGGVSRMSDPKMIKEIQEAVSIPVMAKVRIGHFVEAQILEAIEIDYIDE
                     SEVLSPADDRFHVDKKEFQVPFVCGAKDLGEALRRIAEGASMIRTKGEPGTGDIVQAV
                     RHMRMMNQEIRRIQNLREDELYVAAKDLQVPVELVQYVHEHGKLPVVNFAAGGVATPA
                     DAALMMQLGAEGVFVGSGIFKSGDPVKRASAIVKAVTNFRNPQILAQISEDLGEAMVG
                     INENEIQILMAERGK"
     gene            complement(17043..18422)
                     /locus_tag="VXE25_000022"
     CDS             complement(17043..18422)
                     /locus_tag="VXE25_000022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HEV0770567.1"
                     /translation="MSKIVVVGANHAGTACINTMLDNFGNENEIVVFDQNSNISFLGC
                     GMALWIGEQIDGAEGLFYSDKEKLEAKGAKVYMNSPVLSIDYDNKVVTAEVEGKEHKE
                     SYEKLIFATGSTPILPPIEGVEIVKGNREFKATLENVQFVKLYQNAEEVINKLSDKSQ
                     HLDRIAVVGGGYIGVELAEAFERLGKEVVLVDIVDTVLNGYYDKDFTQMMAKNLEDHN
                     IRLALGQTVKAIEGDGKVERLITDKESFDVDMVILAVGFRPNTALADGKIELFRNGAF
                     LVDKKQETSIPGVYAVGDCATVYDNARKDTSYIALASNAVRTGIVGAYNACGHELEGI
                     GVQGSNGISIYGLHMVSTGLTLEKAKAAGYNATETGFNDLQKPEFMKHDNHEVAIKIV
                     FDKDSREILGAQMVSHDIAISMGIHMFSLAIQEHVTIDKLALTDLFFLPHFNKPYNYI
                     TMAALTAEK"
     gene            18716..19639
                     /locus_tag="VXE25_000023"
     CDS             18716..19639
                     /locus_tag="VXE25_000023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000175414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD:protein FMN transferase"
                     /protein_id="HEV0770568.1"
                     /translation="MTLRSHSERLMGTTITISLVDEQADIFLQKSFDLLKELEYRFNA
                     NSQESELMEINYQAGIAPVTVHPDLFELISLGLEHSLALSSHLNISIGPLIQTWRIGF
                     SDAKVAQPQEIESVLPLINPHGIELDSSTSTVFLKQKGMKIDLGCLAKGYSADKVAQF
                     LRKEGVTSALINLGGNILTIGKNQARGDNPWQIGIQDPANPRGNHLMTIPVVNKSVVT
                     SGIYERHLTVDGQDYHHIFDSQTGYPVETELASLTIISDKSVDGEIWTTRLFGERPAS
                     ILWQVESLEGIEVILIDKEGHLSCSSGIPTL"
     gene            19699..20304
                     /locus_tag="VXE25_000024"
     CDS             19699..20304
                     /locus_tag="VXE25_000024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HEV0770569.1"
                     /translation="MLKLIAIVGTNSKRSTNRQLLQYMQKHFADKAEIELVEIKTIPV
                     FNKPADKQVPAEILEIAAKIEEADGVIIGTPEYDHSIPAVLMSALAWLSYGIYPLLNK
                     PIMITGASYGTLGSSRAQLQLRQILNAPEIKANVLPDEFLLSHSLQAFNPSGDLVDLD
                     VIKKLDAIFDDFRIFVKITEKLRNAQELLRKDAEDFDWENL"
     gene            20322..21566
                     /locus_tag="VXE25_000025"
     CDS             20322..21566
                     /locus_tag="VXE25_000025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000673688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HEV0770570.1"
                     /translation="MKFVGLVGSNYDQSYNRKLLEFIRRNFKFKFELEVLEIDEVPMF
                     NQDEKWDESFQLRFLYNKITRADGVIIATPEHNHTISASLKSVLEWLSYEVHPFENKP
                     VMIVGASYYDQGTSRAQVHLRKILDAPGVNAYTLPGNEFLLGKAKEAFDNNGNITNEG
                     TVKFLETCLDNFVKYVGVVSKLKKPKPIESEDLDCGKPIATTITEVDPDDPEWVEKVA
                     AITGAVSGDTYVKLDHGILTVNQIDMFLKAMPFELTYADDNNQFLYYNNAHQDPDTMF
                     AKRVPPQSGSRMSTVHGSLPPARMKNVEWVIGTLRNGNQEYVRTIVPGSPAGVINTHN
                     YQAMYYPDGSYAGINEIVFNFQPWLDWYLKETGQRLVGGSGPFAPAAGGHGDADATSG
                     ASDSGDAGGHGGDADATAGASY"
     gene            complement(21789..22046)
                     /locus_tag="VXE25_000026"
     CDS             complement(21789..22046)
                     /locus_tag="VXE25_000026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983550.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF896 family protein"
                     /protein_id="HEV0770571.1"
                     /translation="MDPKKIARINELAKKKKTEGLTSEEKVEQAKLREEYIEGYRRAV
                     RHHIEGIKIVDEEGNDVTPEKLRQVQREKGLHGRSLDDPNS"
     gene            complement(22088..24124)
                     /locus_tag="VXE25_000027"
     CDS             complement(22088..24124)
                     /locus_tag="VXE25_000027"
                     /EC_number="6.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine--tRNA ligase subunit beta"
                     /protein_id="HEV0770572.1"
                     /translation="MTKNLLVELGLEELPAYVVTPSEKQLGEKMAAFLKGKRLSFEAI
                     QTFSTPRRLAVRVTGLSDKQSDLTEDFKGPAKKIALDSDGNFTKAAQGFVRGKGLTVE
                     DIEFREIKGEEYVYVTKEEIGQAVEAIVPGIVDVLKSLTFPVSMHWAGNSFEYIRPVH
                     TLTVLLDEEEFDLDFLDIKGGRVSRGHRFLGKETKIQSALSYEEDLRKQFVIADPCER
                     EQMIVDQIKEIEAKHGVRIEIDADLLNEVLNLVEYPTAFMGSFDAKYLEIPEEVLVTS
                     MKEHQRYFVVRDQDGKLLPNFISVRNGNAERLKNVIKGNEKVLVARLEDGEFFWREDQ
                     KLVISDLVEKLNNVTFHEKIGSLREHMIRTGQITVLLAEKAGLSVDETVDLARAAAIY
                     KFDLLTGMVGEFDELQGIMGEKYTLLAGETPAVAAAIREHYMPTSAEGELPESKVGAV
                     LAIADKLDTILSFFSVGLIPSGSNDPYALRRATQGVVRILDAFGWHIAMDELIDSLYA
                     LKFDSLTYENKAEVMNFIKARVDKMMGSTPKDIKEAVLAGSNFVVADMLEAASALVEV
                     SKEEDFKPSVESLSRAFNLAEKAEGVATVDSALFENDQEKALAEAVETLVLSGPASQQ
                     LKQLFALSPVIDAFFENTMVMAEDQAVRQNRLAILSQLTKKAAKFACFNQINTK"
     gene            complement(24336..25253)
                     /gene="glyQ"
                     /locus_tag="VXE25_000028"
     CDS             complement(24336..25253)
                     /gene="glyQ"
                     /locus_tag="VXE25_000028"
                     /EC_number="6.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018163989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine--tRNA ligase subunit alpha"
                     /protein_id="HEV0770573.1"
                     /translation="MSKKLTFQEIILTLQQFWNDQGCMLMQAYDNEKGAGTMSPYTFL
                     RAIGPEPWNAAYVEPSRRPADGRYGENPNRLYQHHQFQVVMKPSPSNIQELYLESLEK
                     LGINPLEHDIRFVEDNWENPSTGSAGLGWEVWLDGMEITQFTYFQQVGGLATGPVTAE
                     VTYGLERLASYIQEVDSVYDIEWADGVKYGEIFIQPEYEHSKYSFEISDQEMLLENFD
                     KFEKEAGRALEEGLVHPAYDYVLKCSHTFNLLDARGAVSVTERAGYIARIRNLARVVA
                     KTFVAERKRLGYPLLDEETRAKLLAEDAE"
     gene            complement(25447..26208)
                     /locus_tag="VXE25_000029"
     CDS             complement(25447..26208)
                     /locus_tag="VXE25_000029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Tu"
                     /protein_id="HEV0770574.1"
                     /translation="MDNLYLVKDDSQLATFRDFVVRNTEKLKDYQSFLKNELAVCDLP
                     QAVIWSDFNAATQIIRESAVPAYTNNRRMVMAPDLAVWKELYLYQLMDYECSQQTQAI
                     ESHYHSLSENFLLQIVGHELAHWSEHFLDDFDGYDSYIWFEEGMVEYISRKYFLTEEE
                     FQAEKICNQSLVELFQKKYSWHSLNDFGSSTYDKNYASIFYEYWRSFLTVDKLVENLG
                     SVQAVLDSYHLWANTEKTFPLLDWFVQQKLIEKEI"
     gene            complement(26481..27323)
                     /locus_tag="VXE25_000030"
     CDS             complement(26481..27323)
                     /locus_tag="VXE25_000030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldo/keto reductase"
                     /protein_id="HEV0770575.1"
                     /translation="MNTYQLNNGVEIPVLGFGTFKAKDGEEAYRAVLEALKAGYRHID
                     TAAIYQNEESVGQAIKDSGVPREEMFVTTKLWNSQQTYEQTRQALEKSIEKLGLDYLD
                     LYLIHWPNPKPLRENDAWKTRNAEVWRAMEDLYQEGKIRAIGVSNFLPHHLDALLETA
                     TIVPAVNQVRLAPGVYQDQVVAYCREKGILLEAWGPFGQGELFDSKQVQEIAANHGKS
                     IAQIALAWSLAEGFLPLPKSVTTSRIQANLDCFGIELSHEERETLKTIAVQSGAPRVD
                     DVDF"
     gene            complement(27437..28828)
                     /locus_tag="VXE25_000031"
     CDS             complement(27437..28828)
                     /locus_tag="VXE25_000031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013193417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HEV0770576.1"
                     /translation="MNKSRLGRGRHGKTRHVLLALIGILAISICLLGGFIAFKIYQQK
                     SFEQKIESLKKEKDDQLSEGNQKEHFRQGQAEVIAYYPLQGEKVISSVRELINQDVKD
                     KLESKDNLVFYYTEQEESGLKGVVNRNVTKQIYDLVAFKVEETEKTSLGKVHLTEDGQ
                     PFTLDQLFSDVSKAKEQLIKELTSFIEDKKIEQDQSEQIVKNFSDQDLSAWNFDYKDS
                     QIILYPSPVVENLEEIALPVSAFFDVIQSSYLLEKDAALYQSYFDKKYQKVVALTFDD
                     GPNPATTPQVLETLAKYDIKATFFVLGKNVSGNEDLVKRIKSEGHVVGNHSWSHPILS
                     QLSLDEAKKQITDTEDVLTKVLGSSSKLMRPPYGAITDDIRNSLDLSFIMWDVDSLDW
                     KSKNEASILTEIQHQVANGSIVLMHDIHSPTVNALPRVIEYLKNQGYTFVTIPEMLNT
                     RLKAHELYYSRDE"
     gene            complement(29063..29440)
                     /locus_tag="VXE25_000032"
     CDS             complement(29063..29440)
                     /locus_tag="VXE25_000032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001833802.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PD-(D/E)XK nuclease family transposase"
                     /protein_id="HEV0770577.1"
                     /translation="MLCQFIRDMLDLPAKNVTILEGSNIHVLPSMPYSAQDFYTSIDV
                     LAELDNGTQVIIEIQVHHQNFFINRLWAYLCSQVNQNLEKIRQREGDTHQSYKQIAPV
                     YAIAIVDSNYFSDDLASHSFIVK"
     gene            29691..30668
                     /locus_tag="VXE25_000033"
     CDS             29691..30668
                     /locus_tag="VXE25_000033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002206301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="HEV0770578.1"
                     /translation="MLKLGVIGTGAISHHFIEAAHTSGEYQLVAIYSRKLETAATFAS
                     RYQNIQLFDQLEVFFKSSFDLVYIASPNSLHFAQAKAALSAGKHVILEKPAVTQPQEW
                     FDLIQTAEKNNCFIFEAARNYHEKAFTTIKNFLADKQVLGADFNYAKYSSKMPDLLTG
                     QTPNVFSDRFAGGALMDLGIYPLYAAVRLFEKANDATYHAQQLDNSIDLNGDGILFYP
                     DYQVHIKAGKNITSNLPCEIYTTDGTLTLNTIEHIRSAIFADHQGNQVQLPIQQAPHT
                     MTEEVAAFAHMIQQPDLNLYQTWLYDAGSVHELLYTMRQTAGIRFEAEK"
     gene            30665..31747
                     /locus_tag="VXE25_000034"
     CDS             30665..31747
                     /locus_tag="VXE25_000034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HEV0770579.1"
                     /translation="MKTKLPTEWQELSDQLGFQEFTPIQTQLFELLLAGENLLGVSQT
                     GTGKTLAYLLPSLLRLQKKKAQQLLILAPNTELAGQIFDVCKTWAEAIGLTAQLFLSG
                     SSQKRQIERLKKGPEILIGTPGRIFELIKLKKIKMMNVETIILDEFDQLLDDSQIHFV
                     EKITHYAPRDHQLVYMSATTKFDQEKIVPNTRTIDLSDQKLDNIQHFYMQVDQRHRVD
                     MLRKLAHVEDFRGLVFFNSLSDLGNAEEKLQYRDILAVSLASDVNVKFRKIILEKFKD
                     NQLTLLLATDLLARGIDIDSLECVVNFDIPRDSETYTHRAGRTGRMGKEGYVITLVTH
                     PEEIKKLKKFASIREIVLKNQELYIK"
     gene            complement(31811..32846)
                     /locus_tag="VXE25_000035"
                     /pseudo
     CDS             complement(31811..32846)
                     /locus_tag="VXE25_000035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611577.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
     gene            complement(33230..34426)
                     /gene="tuf"
                     /locus_tag="VXE25_000036"
     CDS             complement(33230..34426)
                     /gene="tuf"
                     /locus_tag="VXE25_000036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014335040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Tu"
                     /protein_id="HEV0770580.1"
                     /translation="MAKEKYDRSKPHVNIGTIGHVDHGKTTLTAAITTVLARRLPSSV
                     NQPKDYASIDAAPEERERGITINTAHVEYETEKRHYAHIDAPGHADYVKNMITGAAQM
                     DGAILVVASTDGPMPQTREHILLSRQVGVKHLIVFMNKVDLVDDEELLELVEMEIRDL
                     LSEYDFPGDDLPVIQGSALKALEGDSKYEDIVMELMNTVDEYIPEPERDTDKPLLLPV
                     EDVFSITGRGTVASGRIDRGIVKVNDEIEIVGIKEETQKAVVTGVEMFRKQLDEGLAG
                     DNVGVLLRGVQRDEIERGQVIAKPGSINPHTKFKGEVYILTKEEGGRHTPFFNNYRPQ
                     FYFRTTDVTGSIELPAGTEMVMPGDNVTIDVELIHPIAVEQGTTFSIREGGRTVGSGM
                     VTEIEA"
     gene            complement(35348..36217)
                     /locus_tag="VXE25_000037"
     CDS             complement(35348..36217)
                     /locus_tag="VXE25_000037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000348128.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aquaporin family protein"
                     /protein_id="HEV0770581.1"
                     /translation="MDFTWALKYATEFLGTAILIILGNGAVANVELKGTKGHQSGWIV
                     IAVGYGMGVMIPALMFGNVSGNHINPAFTLGLAVSGLFPWAQVVPYIIAQVLGAIFGQ
                     ALVVATYRPFYLKTEKPNNILGTFSTISSIDHGTKESRYAATVNGLINEFVGSFVLFF
                     AALGLTKNFFGAEVLQFMKQKAIEAGQTVDFSDLAIKAQVAPHTASGLSVAHLALGFL
                     VMALVTSLGGPTGPALNPARDLGPRLLHAFLPKSVLGEHKGDSKWWYSWVPVVAPIAA
                     AIAAVAVFKFLYL"
     gene            complement(36440..36961)
                     /locus_tag="VXE25_000038"
     CDS             complement(36440..36961)
                     /locus_tag="VXE25_000038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG cell wall anchor domain-containing
                     protein"
                     /protein_id="HEV0770582.1"
                     /translation="MVPKTATSTETKTITRIIHYVDKVTNQNVKKDVVQPVTLSRTKT
                     ENKVTGVVTYGEWTTGNWDEVISGKIDKYKDPDIPTVESQEVTSDSSDKEITVRYDRL
                     STPDKPTPEPGTPKTETPVNPDPEVPTYETGKREELPNTGTEANATLASAGIMTLLAG
                     LGLGFFKKKEDEK"
     gene            complement(36933..38024)
                     /locus_tag="VXE25_000039"
     CDS             complement(36933..38024)
                     /locus_tag="VXE25_000039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MucBP domain-containing protein"
                     /protein_id="HEV0770583.1"
                     /translation="MNIILIAKPLRENTNTKANALNNGWARSGSEEFKKFSHFVGVDK
                     GIVRTNVLTGKKLSDKIRKEVGSGDSKLGKGGYFSTGDVLLGKDVVSYTVQVFSENNE
                     RVGVNTQSHRVQYNLPILADFSVIQDTVEPSRTVVEKIIPKLNIPEEEKGKITEEIKK
                     KKKTSELAELISENVKVRYVDEQGRLLSLKNDTGIGEKESDGTYITNKKQLIGTSYNV
                     TDKKLSSMTTTDGKYYTFKEVDTNSASLTGNIVSKGRTVTLVYRESEAPTTATVTANY
                     YKEGSQEKLAESVIKADLAIGSEYTTESKTIEGKTTTEDKEDRVITRKTTYTLVATPA
                     NAYQKTVQQLTITTVRMLRKSGSQNSNLY"
     gene            complement(38135..38389)
                     /locus_tag="VXE25_000040"
     CDS             complement(38135..38389)
                     /locus_tag="VXE25_000040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0770584.1"
                     /translation="MLNVDQDFMSISKSNKSGSDWKKTFTVRITNRLANDLNNVLKQA
                     DKDTPNTPTWLNSAASKAKDDDRAYKLLKTLIPGENYLSC"
     gene            complement(38747..39280)
                     /locus_tag="VXE25_000041"
     CDS             complement(38747..39280)
                     /locus_tag="VXE25_000041"
                     /inference="COORDINATES: protein motif:HMM:NF024751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
                     /protein_id="HEV0770585.1"
                     /translation="MTSFKEQEPEKVAEFLDILDNLKDLPIVYIDETGIDRYLYRPYA
                     GAPRGEKVYEKISGRRFERTSIVAGQVDGEFIAPMIYKKSMTSDFFVEWFKTQLLPAL
                     KTPHVIVMGNASFHPKNILDELCIQDKHFFLPLPPYSPDLNPIEQAWAILKKKVTDLL
                     REVPTIFECLECFFKTR"
     gene            complement(39267..39482)
                     /locus_tag="VXE25_000042"
     CDS             complement(39267..39482)
                     /locus_tag="VXE25_000042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEV0770586.1"
                     /translation="MGKERCEQEHIERKKRVVKNRKIPLEELKTFVEAHPDAFLREIA
                     AHFDCAVPSVWAALKQIKVTLKKDDEL"
     gene            complement(39449..39592)
                     /locus_tag="VXE25_000043"
     CDS             complement(39449..39592)
                     /locus_tag="VXE25_000043"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007285173.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tnpB"
                     /protein_id="HEV0770587.1"
                     /translation="MAYSTDFKQRALDYIKEGHSHVEAAKFFGVGVRTLFTWEKKDVN
                     KNT"
     gene            39826..41544
                     /locus_tag="VXE25_000044"
     CDS             39826..41544
                     /locus_tag="VXE25_000044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004252698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-sugar mutase"
                     /protein_id="HEV0770588.1"
                     /translation="MSYQENYQKWVDFVELPDYLRQDLENMDEKTKEDAFYTNLEFGT
                     AGMRGLVGAGTNRINIYVVRQATEGLARLIESKGGNEKERGVAIAYDSRHFSPEFAFE
                     SAAVLAKHGIKSYVFESLRPTPELSFAVRHLNCFAGIMVTASHNPAPFNGYKVYGEDG
                     GQMPPHDADALTTYIRAIENPFAVEVADVETEKASGLIEVIGEAVDIEYLKEVKDINI
                     NPALIEEFGKDMKIVYTPLHGTGEMLARRALAQAGFDSVQVVEAQATADPDFSTVTSP
                     NPESQAAFALAEELGRQVGADVLVATDPDADRVGVEVLQKDGSYLNLSGNQIGAIMAK
                     YILEAHKNAGTLPENAALCKSIVSTDLVTKIAESYGATMFNVLTGFKFIAEKIQEFEE
                     KHNHTYMMGFEESFGYLIKPFVRDKDAIQAVLVVAELAAYYRSRGLTLADGIEEIYKE
                     YGYYAEKTISVTLSGVDGAEQIKAIMAKFRNNAPTEWNATAITVVEDFKAQTATVADG
                     TVTNLTTPPSDVLKYTLADGSWIAVRPSGTEPKIKFYIAVVGETNEESQAKITNIEAE
                     INAFVK"
     gene            41655..42002
                     /locus_tag="VXE25_000045"
     CDS             41655..42002
                     /locus_tag="VXE25_000045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000434646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="HEV0770589.1"
                     /translation="MEQFLDNIKDLEVTTVVRAQEALDKKETATFFIGRKTCPYCRKF
                     AGTLSGVVAETKAHIYFINSEEPSQLNDLQAFRSRYGIPTVPGFVHITDGQINVRCDS
                     SMSAQEIKDFAGL"
     gene            complement(42280..43116)
                     /locus_tag="VXE25_000046"
     CDS             complement(42280..43116)
                     /locus_tag="VXE25_000046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000759190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="HEV0770590.1"
                     /translation="MKKWMLVLVSLMTALFLVACGKNSSETSGDNWSKYQSNKSITIG
                     FDSTFVPMGFAQKDGSYAGFDIDLATAVFEKYGITVNWQPIDWDLKEAELTKGTIDLI
                     WNGYSATDERREKVAFSNSYMKNEQVLVTKKSSGITTAKDMTGKTLGAQAGSSGYADF
                     EANPEILKNIVANKEANQYQTFNEALIDLKNDRIDGLLIDRVYANYYLEAEGVLNDYN
                     VFTVGLETEAFAVGARKEDTNLVKKINEAFSSLYKDGKFQEISQKWFGEDVATKEVKE
                     GQ"
     gene            complement(43129..43758)
                     /locus_tag="VXE25_000047"
     CDS             complement(43129..43758)
                     /locus_tag="VXE25_000047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000891751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEV0770591.1"
                     /translation="MLELRNINKVFGDKQILSNFSLSIPEKQILAIVGPSGGGKTTLL
                     RMLAGLETIDSGQIFYNGQPLELDELQKRNLLGFVFQDFQLFPHLSVLENLTLSPVKT
                     MGMKQEEAEKKASGLLEQLGLGGHAEAYPFSLSGGQKQRVALARAMMIDPEIIGYDEP
                     TSALDPELRLEVEKLILQNRELGMTQIVVTHDLQFAENIADVLLKVEPK"
     gene            complement(43768..44409)
                     /locus_tag="VXE25_000048"
     CDS             complement(43768..44409)
                     /locus_tag="VXE25_000048"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004253193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEV0770592.1"
                     /translation="MSYLFEILPSLLNGASTTVQVFALVLLFSIPLGVLIAFALQVHW
                     KPLHYLINIYIWVMRGTPLLLQLIFIYYVLPSIGIRLDRLPAAIIAFVLNYAAYFAEI
                     FRGGIDTIPRGQYEAAKVLKFSPFDRVRYIILPQVTKIVLPSVFNEVMSLVKDTSLVY
                     ALGISDLILASRTAANRDASLVPMFLAGAIYLILIGIVTIISKKVEKKYSYYR"
     gene            complement(44555..45784)
                     /locus_tag="VXE25_000049"
     CDS             complement(44555..45784)
                     /locus_tag="VXE25_000049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864303.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetratricopeptide repeat protein"
                     /protein_id="HEV0770593.1"
                     /translation="MNNSQQMLQALEEQDLTKAEHYFAKALENDSSDLLYELATYLEG
                     IGFYPQAKEIYLKIVEDFPEVHLNLAAIASEDGQIEEAFTYLEEIQADSDWYVSSLAL
                     KADLYQLEGLTDVAREKLLEALTYSEDSLLILGLAELDSELENYQAAIQAYAQLDNRS
                     IYEQTGISTYQRIGFAYAQLGKFETATEFLEKALELEYDDLTAFELANLYFDQEEYQK
                     ATLYFKQLDTISPDFEGYEYGYSQALHKEHQVQEALRIAKQGLEKNPFETRLLLAASQ
                     FSYELHDASGAENYLLAAKEDAEDTEEILLRLATIYLEQERYEDILDLQSEEPENLLT
                     KWMIARSYQEMDDLDTAYEHYQELTGDLKDNPEFLEHYIYLLRELGHFEEAKVHAHTY
                     LKLVPDDVQMQELFERL"
     gene            complement(45774..46940)
                     /locus_tag="VXE25_000050"
     CDS             complement(45774..46940)
                     /locus_tag="VXE25_000050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000435446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HEV0770594.1"
                     /translation="MEQKEKHFSLSWFFKWFLDNKAITVFLVTLLLGLNLFILSKISF
                     LFSPVLDFLAVVMLPVILSGLLYYLLNPIVDWMEKHKVNRVIAITIVFVIIALFIIWG
                     LAVAIPNLQRQVLTFARNVPVYLEDIDRIVNGLVAQHLPDDFRPQLEQVLTNFSSQAT
                     VLASKVSSQAVNWVSAFISGASQVIVALIIVPFMLFYLLRDGKGLRNYLTQFIPRKLK
                     EPVGQVLSDVNQQLSNYVRGQVTVAIIVAVMFIIFFKIIGLRYAVTLGVTAGILNLVP
                     YLGSFLAMFPALVLGLIAGPVMLLKVVIVFIVEQTIEGRFVSPLILGSQLNIHPINVL
                     FVLLTSGSMFGIWGVLLGIPVYASAKVVISAIFEWYKVVSGLYELEGEEVKSEQ"
     gene            47084..48097
                     /locus_tag="VXE25_000051"
     CDS             47084..48097
                     /locus_tag="VXE25_000051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000665618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactonase family protein"
                     /protein_id="HEV0770595.1"
                     /translation="MKETVYFGTYTRRTSQGIYKADFDTETGQLSNLELFAAEPSPTY
                     LAFDQHQHLYTVGSQDDKGGIAAYQTDGTVLNHVVEEGAPHCYVAVDEKRDLVYAANY
                     HKGQVLVYKRQEDGSLLLSDMDQHSGQGPHENQASPHVHYTDLTPDHYLVTCDLGTDQ
                     VITYDLDQEGKLSKLYTYHSKPGAGSRHIIFHNHYKIAYLICELNSTIEVLIYDGVGE
                     FERMQVISTLPEAYEGFNGTAAIHLSKDGKYLYASNRGHDSIAVYTILADGSLELLEI
                     VPTHGQTPRDFDLTPDQKFLIVVHQDSDNATVFKRNCDNGRLAELSNDFHVPEAVCIR
                     FAP"
     gene            complement(48142..48561)
                     /locus_tag="VXE25_000052"
     CDS             complement(48142..48561)
                     /locus_tag="VXE25_000052"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397408.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit epsilon"
                     /protein_id="HEV0770596.1"
                     /translation="MAQLTVQIVTPDGLVYDHHASYVSVRTLDGEMGILPRHENMIAV
                     LAVDEVKVKRIDDKDHVNWIAVNGGVIEIANDMITIVADSAERARDIDISRAERAKLR
                     AERAIEEAQDKHLIDQERRAKIALQRAINRINVGNRL"
     gene            complement(48572..49978)
                     /gene="atpD"
                     /locus_tag="VXE25_000053"
     CDS             complement(48572..49978)
                     /gene="atpD"
                     /locus_tag="VXE25_000053"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit beta"
                     /protein_id="HEV0770597.1"
                     /translation="MSSGKIAQVIGPVVDVLFAAGEKLPEINNALVVYKNDERKTKIV
                     LEVALELGDGMVRTIAMESTDGLTRGMEVLDTGRPISVPVGKETLGRVFNVLGDTIDL
                     EAPFTEDAERQPIHKKAPTFDELSTSSEILETGIKVIDLLAPYLKGGKVGLFGGAGVG
                     KTVLIQELIHNIAQEHGGISVFTGVGERTREGNDLYWEMKESGVIEKTAMVFGQMNEP
                     PGARMRVALTGLTIAEYFRDVEGQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQP
                     TLATEMGQLQERITSTKKGSVTSIQAIYVPADDYTDPAPATAFAHLDSTTNLERKLVQ
                     LGIYPAVDPLASSSRALAPEIVGEEHYAVAAEVKRVLQRYHELQDIIAILGMDELSDE
                     EKTLVARARRIQFFLSQNFNVAEQFTGQPGSYVPVAETVRGFKEILDGKYDHLPEDAF
                     RGVGSIEDVIAKAEKMGF"
     gene            complement(50064..50942)
                     /locus_tag="VXE25_000054"
     CDS             complement(50064..50942)
                     /locus_tag="VXE25_000054"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002895995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit gamma"
                     /protein_id="HEV0770598.1"
                     /translation="MAVSLNDIKTKIASTKNTSQITNAMQMVSAAKLGRSEEAARNFQ
                     VYAQKVRKLLTDILHGNGAGASTNPMLISRSVKKTGYIVITSDRGLVGGYNSSILKAV
                     MELKEEYHPDGKGFEMICIGGMGADFFKARGIQPLYELRGLADQPSFDQVRKIISKTV
                     EMYQNELFDELYVCYNHHVNTLTSQMRVEQMLPIVDLDPNEADEEYSLTFELETSREE
                     ILEQLLPQFAESMIYGAIIDAKTAENAAGMTAMQTATDNAKKVINDLTIQYNRARQAA
                     ITQEITEIVAGASALE"
     gene            complement(50958..52463)
                     /locus_tag="VXE25_000055"
     CDS             complement(50958..52463)
                     /locus_tag="VXE25_000055"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit alpha"
                     /protein_id="HEV0770599.1"
                     /translation="MAINAQEISALIKQQIENFKPNFDVTETGVVTYIGDGIARAHGL
                     ENVMSGELLNFENGSYGMAQNLESTDVGIIILGDFTDIREGDTIRRTGKIMEVPVGES
                     LIGRVVDPLGRPVDGLGEIHTDKTRPVEAPAPGVMQRKSVSEPLQTGLKAIDALVPIG
                     RGQRELIIGDRQTGKTTIAIDTILNQKDQDMICIYVAIGQKESTVRTQVETLRQYGAL
                     DYTIVVTASASQPSPLLFLAPYTGVAMAEEFMYQGKHVLIVYDDLSKQAVAYRELSLL
                     LRRPPGREAFPGDVFYLHSRLLERSAKVSDELGGGSITALPFIETQAGDISAYIATNV
                     ISITDGQIFLGDGLFNAGIRPAIDAGSSVSRVGGSAQIKAMKKVAGTLRIDLASYREL
                     EAFTKFGSDLDAATQAKLNRGRRTVEVLKQPVHKPLPVEKQVTILYALTHGFLDTVPV
                     DDIVRFEEEFHAFFDAQHPEILETIRDTKDLPEEAVLDAAITEFLNQSSFQ"
     gene            complement(52478..53014)
                     /locus_tag="VXE25_000056"
     CDS             complement(52478..53014)
                     /locus_tag="VXE25_000056"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358986.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit delta"
                     /protein_id="HEV0770600.1"
                     /translation="MDKKTVKVIEKYSMPFVQLVLEKGEEDRIFSDLTQIKQVVEKTG
                     LPSFLKQVAVDESDKEKTIAFFQDSVSPLLQNFIQVLAYNHRANLFYDVLVDCLNRLE
                     KETNRFEVTITSAHPLTDEQKTRLLPLIEKKMSLKVRSVKEQIDESLIGGFVIFANHK
                     TIDVSIKQQLKVVKENLK"
     gene            complement(53014..53508)
                     /gene="atpF"
                     /locus_tag="VXE25_000057"
     CDS             complement(53014..53508)
                     /gene="atpF"
                     /locus_tag="VXE25_000057"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit B"
                     /protein_id="HEV0770601.1"
                     /translation="MHVTVGELIGNFILITGSFILLLVLIKKFAWSNITGIFEERAEK
                     IASDIDRAEEARQKAEVLAQKREDELAGSRKEAKTIIENAKETAEQSKANILADAKLE
                     AGHLKEKANQEIAQNKVEALQSVKGEVADLTISLAGKIISQNLDSHAHKALIDQYIDQ
                     LGEA"
     gene            complement(53522..54238)
                     /gene="atpB"
                     /locus_tag="VXE25_000058"
     CDS             complement(53522..54238)
                     /gene="atpB"
                     /locus_tag="VXE25_000058"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000392848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit A"
                     /protein_id="HEV0770602.1"
                     /translation="MEESINPIISIGPVIFNLTMLAMTLLIVGVIFVFIYWASRNMTL
                     KPKGKQNVLEYVYDFVIGFTEPNIGSRYMKDYSLFFLCLFLFMVIANNLGLMTKIQTI
                     DGTNWWSSPTANLQYDLTLSFLVILLTHIESVRRRGFKKSIKSFMSPVFVIPMNILEE
                     FTNFLSLALRIFGNIFAGEVMTSLLLLLSHQAIYWYPVAFGANLAWTAFSVFISCIQA
                     YVFTLLTSVYLGNKINIEEE"
     gene            complement(54273..54473)
                     /locus_tag="VXE25_000059"
     CDS             complement(54273..54473)
                     /locus_tag="VXE25_000059"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015545704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit C"
                     /protein_id="HEV0770603.1"
                     /translation="MNLTFLGLCIACMGVSVGEGLLMNGLFKSVARQPDMLSEFRSLM
                     FLGVAFIEGTFFVTLVFSFIIK"
     gene            complement(54548..55558)
                     /locus_tag="VXE25_000060"
                     /pseudo
     CDS             complement(54548..55558)
                     /locus_tag="VXE25_000060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001841499.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
     gene            complement(55969..56367)
                     /locus_tag="VXE25_000061"
     CDS             complement(55969..56367)
                     /locus_tag="VXE25_000061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000428147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0770604.1"
                     /translation="MENKESHKSQEIGNLIRVYNRSKREEAESEPLNLYVEDEKGNLL
                     AGLIAETFGNWLEIEYLFVKEELRGQGIGSKLLQQAESEAKNRNCCFAFVNTYQFQAP
                     DFYQKHGYKEVFSLQDYLYIRQRYYYQKNL"
     gene            56495..56572
                     /locus_tag="VXE25_000062"
                     /pseudo
     CDS             56495..56572
                     /locus_tag="VXE25_000062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002674100.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            complement(56785..57267)
                     /gene="greA"
                     /locus_tag="VXE25_000063"
     CDS             complement(56785..57267)
                     /gene="greA"
                     /locus_tag="VXE25_000063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018370745.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription elongation factor GreA"
                     /protein_id="HEV0770605.1"
                     /translation="MAEKTYPMTLEEKEKLEKELEELKLVRRPEVVERIKIARSYGDL
                     SENSEYEAAKDEQAFVEGQISSLETKIRYAEIVNSDAVAQDEVAIGKTVTIQEIGEDE
                     EEVYIIVGSAGADAFAGKVSNESPIGQALIGKKTGDTATIETPVGSYDVKILKVEKTA
                     "
     gene            complement(57338..58993)
                     /gene="mltG"
                     /locus_tag="VXE25_000064"
     CDS             complement(57338..58993)
                     /gene="mltG"
                     /locus_tag="VXE25_000064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001291636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endolytic transglycosylase MltG"
                     /protein_id="HEV0770606.1"
                     /translation="MSEKSREEEKLSFKEQILRDLEKVKGYDEVLKEDEAVVRTPANE
                     PSAEELMADSLSTVEEIMRKAPTVSTHPSQGVPASPADEIQRETPGVPSHPSQDVPSS
                     PAEESGSRPGPGPVRPKKLEREYNETPTRVAVSYTTAEKKAEQAGPETPTPATETVDI
                     ISDTSRRSRREGAKPVNPKKEKKSHVKAFVISFLVFLALLSAGGYFGYQYVLDSLLPI
                     DANSKKYVTVGIPEGSNVQEIGTTLEKAGLVKHGLIFSFYAKYKNYTDLKAGYYNLQK
                     SMSTEDLLKELQKGGTDEPQEPVLATLTIPEGYTLDQIAQAVGQLQGDFKESLTAEAF
                     LAKVQDETFISQAVAKYPTLLESLPVKDSGARYRLEGYLFPATYSIKESTTIESLIDE
                     MLAAMDKNLSPYYSTIKSKNLTVNELLTIASLVEKEGAKTEDRKLIAGVFYNRLNRDM
                     PLQSNIAILYAQGKLGQNISLAEDVAIDTNIDSPYNVYKNVGLMPGPVDSPSLDAIES
                     SINQTKSDNLYFVADVTEGKVYYANNQEDHDRNVAEHVNSKLN"
     gene            complement(59074..59568)
                     /locus_tag="VXE25_000065"
     CDS             complement(59074..59568)
                     /locus_tag="VXE25_000065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000702438.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0770607.1"
                     /translation="MKIRQARLEDLDRIVELEFENFSVEEAIPPSVFEAHLREIQTSF
                     LVAEKEGRIMGYIEGPVGLHRHLQDQSFTEEIKDYSHEPGGYISVTCLSIAKEAQGLG
                     LGQKLLTALKEVALEDERDGINLTCHDYLIAYYEKHGFVNEGQSQSTFAGETWYDMVW
                     EMKK"
     gene            complement(59565..60029)
                     /locus_tag="VXE25_000066"
     CDS             complement(59565..60029)
                     /locus_tag="VXE25_000066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0770608.1"
                     /translation="MEIPIKIIQASKSDLPEIGALQTSSFPAEKQQLSHILEESIRKC
                     ADTFLLARDENQLLGYILSSPQSDNPQYLKVHSLVIESDHQRQGLGTLLLAALKEVAV
                     ELDYKGIRLESPDELLSYFEMNGFVDEEATLLYATSQGYSMIWFNPFYLEEQ"
     gene            complement(60039..61373)
                     /locus_tag="VXE25_000067"
     CDS             complement(60039..61373)
                     /locus_tag="VXE25_000067"
                     /EC_number="6.3.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramate--L-alanine ligase"
                     /protein_id="HEV0770609.1"
                     /translation="MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGL
                     EQAGITILPFDEKNLDGDMEIIAGNAFRPDNNVEIAYADQNGISYKRYHEFLGSFMRD
                     FVSMGVAGAHGKTSTTGMLSHVLSHITDTSFLIGDGTGRGSANAKYFVFESDEYERHF
                     MPYHPEYSIITNIDFDHPDYFTSLEDVFNAFNDYAKQITKGLFVYGEDAELRKITSDA
                     PIYYYGFEVEGNDFVASDLLRSITGSTFTVHFRGQNLGQFHIPTFGRHNIMNATAVIG
                     LLYTAGFDLNLVREHLKTFAGVKRRFTEKIVNDTVIIDDFAHHPTEIIATLDAARQKY
                     PSKEIVAVFQPHTFTRTIALLDDFAHALNQADAVYLAQIYGSAREVDHGDVKVEDLAN
                     KINKKHQVITVENVSPLLDHDNAVYVFMGAGDIQTYEYSFERLLSNLTSNVQ"
     gene            complement(61384..62001)
                     /locus_tag="VXE25_000068"
     CDS             complement(61384..62001)
                     /locus_tag="VXE25_000068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000808222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cystathionine gamma-synthase"
                     /protein_id="HEV0770610.1"
                     /translation="MKQERFPLVSDDEVMLTEMPVMNLYDESDLISNIKGEYRDKNYL
                     EWAPIAEEKPVKPIEKQVEKPKKAPLGVKKEGKSYAEVAREEARADLKKKRSANYLTQ
                     DFSLARRHSQPSLVRQGNQPTTPFQKENPGEFVKYSQKLTQSHYILAEEVHSIPTKNE
                     EVSAPAPKKNNYDFLKKSQIYNKKSKQTEQERRVAQELNLTRMTE"
     gene            complement(62049..65147)
                     /locus_tag="VXE25_000069"
     CDS             complement(62049..65147)
                     /locus_tag="VXE25_000069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001096241.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HEV0770611.1"
                     /translation="MAKLIPGKVRIEGVALYETGKVDIIKEKNNRLYARVAEEELRYS
                     LEDDLVFCACDSFQKRGYCVHLAALEHFLKNDERGQEILWSLEEGHEEKEAVETKVTL
                     GGKFLNRILSPKSECAYELSAVGQVEAGTNHILWTLRIGQINRQKYYVIRDIPLFLRI
                     VEQRKSYMIGKIYEESLSWEAFDDASQELLTFLHGLTEEGLVPDLFFQNQGRHLFFPL
                     TFFEQGVNLLMALPHFQFDHQVDSYQTLLFQDMHADTNLFAFTVTEYSDYFEMEISES
                     PRVNVFYQGAVLFHKGQVYFLTDQQMRLLKEIKVLPVGQQGKKYLQFDSSDRDKLASC
                     LTLFIQMGTVSAPERLQIKTFAPSFYFDREEDNRIRLEIQFDYGNRQVSSRQELEELP
                     FSSDADLEERIFQVCLAAGFEADFQSWRQALKAESVYHFFHDIIPVFEKLGHVDLSDK
                     LEELYSLASPQVQIASKGGLLEIQFDFQNIAQEEIDQAMQALVANQDFYIDSSNQVYF
                     FDEETKKIRQNLQELGQFELKDGTLQARKSLAYSLAHLFEGRDRVSFSQEFQNLAQDL
                     THPEDFPLQATQVKADLRDYQEKGIGWLQMLHHYGFGGILADDMGLGKTLQTIAFLTS
                     QVTKESRVLILAPSGLIYNWADEFQKFAPQLDVAVVHGLKASREEILADSHQIYVTSY
                     ATFRQDSELYQGMAFDFLFLDEAQVMKNAQTKIAQTLRQFVVPSVFALSGTPIENHLG
                     ELWSIFQIVMPGLLPSKKEFMKLPAERVAQFIKPFVMRRKKEEVLTELPDLIEVVYKN
                     ELEDQQKAIYLAQLQQMRDHLAQVSEQEFQRSRVEILSGLMRLRQICDTPALFMEDYQ
                     GASGKLDSLRDLLVQVADGGHRVLIFSQFKGMLEKIEQELPDLGLTSFKITGSTPAKE
                     RQDMTKAFNQGERDAFLISLKAGGVGLNLTGADTVILVDLWWNPAVEAQAIGRAHRMG
                     QEETVEVYRLVTKGTIEEKIQELQEQKKHLVSQVLDGTESRGSLTLAEIREILGISEA
                     ST"
     gene            complement(65240..66406)
                     /locus_tag="VXE25_000070"
     CDS             complement(65240..66406)
                     /locus_tag="VXE25_000070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000521357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HEV0770612.1"
                     /translation="MGKYDFTSLPNRLGHHTYKWKETETDSEVLPAWIADMDFVVLPE
                     IRQAVQTYADQLVYGYTYASEDLIKEVQKWEATQYGYNFDKEALVFIEGVVPAISTAI
                     QTFTKEGEAVLINTPVYPPFARSVKLNNRRLITNSLVEKDGLFEIDFDQLEKDLVEEE
                     VKLYILCNPHNPGGRVWEKEVLEKIGQLCQKHGVLLVSDEIHQDLTLFGHKHQSFNTI
                     NPAFKNFAIVLSSATKTFNIAGTKNSYAVIENPKLRLAFQKRLLANNQHEISGLGYLA
                     TEAAYRYGKDWLEELKQVFEDHINYVVDLFGKETKIKVMKPQGTYLIWLDFSAYDLTD
                     ETLQELLRNESKVILNRGLDFGEEGSLHARINIAMPKSLLQEVCQRIVATFAKR"
     gene            complement(66414..67508)
                     /locus_tag="VXE25_000071"
     CDS             complement(66414..67508)
                     /locus_tag="VXE25_000071"
                     /EC_number="2.5.1.48"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cystathionine gamma-synthase"
                     /protein_id="HEV0770613.1"
                     /translation="MSKELHINTILAQAGIKSDEATGALVTPLHFSTTYQHPEFGRST
                     GFDYTRTKNPTRSKAEEVFAAIESADYALATSSGMSAIVLAFSVFPVGSKVLAVRDLY
                     GGSFRWFNQVEQEGRFHFTYANTEEELIAELEKDVDVLYIETPTNPLMLEFDIEKLAK
                     LAHAKGAKVVVDNTFYSPIYQRPIEDGADIVLHSATKYLAGHNDVLAGVVVTNSLELY
                     EKLFYNLNTTGAVLSPFDSYQLLRGLKTLSLRMERSTANAQEVVAFLKDSPAVKEVLY
                     TGRGGMISFKVADETRIPHILNSLKVFSFAESLGGVESLITYPTTQTHADIPAEVRHS
                     YGLTDDLLRLSIGIEDARDLIADLRQALEG"
     gene            complement(67666..69348)
                     /locus_tag="VXE25_000072"
                     /pseudo
     CDS             complement(67666..69348)
                     /locus_tag="VXE25_000072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000768988.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
     gene            complement(69520..71478)
                     /locus_tag="VXE25_000073"
     CDS             complement(69520..71478)
                     /locus_tag="VXE25_000073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000748873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HEV0770614.1"
                     /translation="MKKSKSKYLTLAGLVLGTGVLLSACGNSSTASKTYNYVYSSDPS
                     SLNYLAENRAATSDIVANLVDGLLENDQYGNIIPSLAEDWTVSQDGLTYTYKLRKDAK
                     WFTSEGEEYAPVTAQDFVTGLQYAADKKSEALYLVQDSVAGLDDYITGKTSDFSTVGV
                     KALDDQTVQYTLVKPELYWNSKTLATILFPVNADFLKSKGDDFGKADPSSILYNGPFL
                     MKALVSKSAIEYKKNPNYWDANNVFVDDVKLTYYDGSDQESLERNFTAGAYTTARLFP
                     NSSSYEGIKEKYKNNIIYSMQNSTSYFFNFNLDRKSYNYTSKTSDIEKKSTQEAVLNK
                     NFRQAINFAFDRTSYGAQSEGKEGATKILRNLVVPPNFVSIKGKDFGEVVASKMVNYG
                     KEWQGINFADGQDPYYNPEKAKAKFAEAKKELEAKGVQFPIHLDKTVEVTDKVGIQGV
                     SSIKQSIESVLGSDNVVIDIQQLTSDEFDSSGYFAQTAAQKDYDLYHGGWGPDYQDPS
                     TYLDIFNTNSGGFLQNLGLEPGEANDKAKAVGLDVYTQMLEEANKEQDPAKRYEKYAD
                     IQAWLIDSSLVLPSVSRGGTPSLRRTVPFAAAYGLTGTKGVESYKYLKVQDKIVTTDE
                     YAKAREKWLKEKEESNKKAQEELAKHVK"
     gene            complement(71682..73304)
                     /locus_tag="VXE25_000074"
     CDS             complement(71682..73304)
                     /locus_tag="VXE25_000074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis protein"
                     /protein_id="HEV0770615.1"
                     /translation="MSHENNHQQAQMLRGTAWLTASNFISRLLGAVYIIPWYIWMGAY
                     AAKANGLFTMGYNIYAWFLLVSTAGIPVAVAKQVAKYNTMREEEHSFALIRSFLGFMT
                     GLGLVFALVLYVFAPWLADLSGVGKDLIPIMQSLAWGVLIFPSMSVIRGFFQGMNNLK
                     PYAMSQIAEQVIRVIWMLLATFIIMKLGSGDYLAAVTQSTFAAFVGMVASFAVLIYFL
                     AQEGSLKRVFETGDKINSKRLLVDTIKEAIPFILTGSAIQLFQILDQLTFINSMSWFT
                     NYSNEDLVVMFSYFSANPNKITMILISVGVSIGSVGLPLLTENYVKGDLKAASRLVQD
                     SLTLLFMFLLPATVGVVMVGEPLYTVFYGKPDSLALGLFVFAVLQSIILGLYMVLSPM
                     LQAMFRNRKAVLYFIYGSIAKLVLQLPTIALFHSYGPLISTTIALIIPNVLMYRDICK
                     VTGVKRKVILKRTILISLLTLVMFLLIGTIQWLLGFFFQPSGRLWSFFYVALVGAMGG
                     GLYMVMSLRTYLLDKVIGKAQADRLRAKFKLS"
     gene            73410..74855
                     /locus_tag="VXE25_000075"
     CDS             73410..74855
                     /locus_tag="VXE25_000075"
                     /EC_number="6.3.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-
                     lysine ligase"
                     /protein_id="HEV0770616.1"
                     /translation="MIKIETVLDILKKDGLFREIIDQGHYHYNYSKVIFDSISYDSRK
                     VTEDTLFFAKGAAFKKEYLLSAITQGLAWYVAEKDYEVGIPVIIVNDIKKAMSLIAME
                     FYGNPQEKLKLLAFTGTKGKTTAAYFAYNILSQGHRPAMLSTMNTTLDGETFFKSALT
                     TPESIDLFDMMNQAVQNDRTHLIMEVSSQAYLVKRVYGLTFDVGVFLNISPDHIGPIE
                     HPSFEDYFYHKRLLMENSRAVIINSDMDHFSVLKEQVEDQDHDFYGSQFDNQIENSKA
                     FSFSATGKLAGDYDIQLIGNFNQENAVAAGLACLRLGASLEDIKKGIAATRVPGRMEV
                     LTQKNGAKVFIDYAHNGDSLKKLINVVETHQTGKIALVLGSTGNKGESRRKDFGLLLN
                     QHPEIQVFLTADDPNYEDPMVIADEISSYINHPVEKIADRQEAIKAAMAITNHELDAV
                     IIAGKGADCYQIIQGKKESYPGDTAVAENYL"
     gene            complement(74794..75048)
                     /locus_tag="VXE25_000076"
     CDS             complement(74794..75048)
                     /locus_tag="VXE25_000076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000051194.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CsbD family protein"
                     /protein_id="HEV0770617.1"
                     /translation="MSLENKLEQATGAVKEGFGKVTGDSKTELEGAVEKTVAKAKDVV
                     EDAKGAVEGAVEGLKNVFSILINNFLRRLYLLGRILSCPG"
     gene            complement(75149..75667)
                     /locus_tag="VXE25_000077"
     CDS             complement(75149..75667)
                     /locus_tag="VXE25_000077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001850249.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1803 domain-containing protein"
                     /protein_id="HEV0770618.1"
                     /translation="MIRYLDQYEDVILCENKRHYLNFPTLESLDSLELDQEIFVREAS
                     PVYQALLEQSFETELRNQINAAILVEKTDFARIKMTLSNYFYKVKQQYPLTEKQQELY
                     DILGDVNPEYALKYMTAFLLKFLKKDQLMQKCRDIFVDSLVVLGYIVQNEDRKYELAI
                     DFDKERLTFYLA"
     gene            complement(75704..76216)
                     /locus_tag="VXE25_000078"
     CDS             complement(75704..76216)
                     /locus_tag="VXE25_000078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000892254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoylalanyl-D-glutamate--2,
                     6-diaminopimelate ligase"
                     /protein_id="HEV0770619.1"
                     /translation="MLENGDLIFVRDGSDMGQAIQTSTGNYSHVAIYLDGMIYHASGQ
                     AGVVCQEPADFFESNHLYDLYVYPEMDIQSVKERACKHLGAPYNASFYPDAAGFYCSQ
                     YIAEILPIFETIPMKFGDGEQEISDFWREYYIELGLPVPLNQAGTNPSQLAASPLLQC
                     KERNLRDSDF"
     gene            complement(76302..77237)
                     /locus_tag="VXE25_000079"
     CDS             complement(76302..77237)
                     /locus_tag="VXE25_000079"
                     /EC_number="3.6.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000036024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="manganese-dependent inorganic pyrophosphatase"
                     /protein_id="HEV0770620.1"
                     /translation="MSKILVFGHQNPDSDAIGSSVAFAYLAKEAYGLDTEAVALGTPN
                     EETAFVLNYFGVEAPRVITSAKAEGAEQVILTDHNEFQQSVSDIAEVEVYGVVDHHRV
                     ANFETASPLYMRLEPVGSASSIVYRMFKEHGVAVPKEIAGLMLSGLISDTLLLKSPTT
                     HPTDKIIAPELAELAGVNLEEYGLAMLKAGTNLASKSAEELIDIDAKTFELNGNNVRV
                     AQVNTVDIAEVLERQAEIEAAMQAANESNGYSDFVLMITDIVNSNSEILALGANMDKV
                     EAAFNFKLENNHAFLAGAVSRKKQVVPQLTESFNA"
     gene            complement(77308..77607)
                     /locus_tag="VXE25_000080"
     CDS             complement(77308..77607)
                     /locus_tag="VXE25_000080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GIY-YIG nuclease family protein"
                     /protein_id="HEV0770621.1"
                     /translation="MDHKAYMYVLECRDGSYYIGYTTDMRRRLAIHNSGKGAKYTRAR
                     LPVKLIYAQGFASKEEAMSAEALLKRKKRPQKEEFLSENQDRNLLSYFEESWGVL"
     gene            complement(77597..78346)
                     /locus_tag="VXE25_000081"
     CDS             complement(77597..78346)
                     /locus_tag="VXE25_000081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000390787.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase"
                     /protein_id="HEV0770622.1"
                     /translation="MEEEQLLKSGERINQLFSTDIKIIQNREVFSYSVDSVLLSRFPR
                     FPKKGLIVDFCAGNGAVGLFASTRTQAQILSVEIQERLADMAERSVRLNGLEEQMQVI
                     CDDLKNMPAHIQGSKVDMILCNPPYFKVDPYSNLNESEHYLLARHEITTNLEEICHSA
                     QSILKSNGRLAMVHRPDRLLDILDTLKRHNLAPKRLQFVYPKREKEANMLLIEAIKDG
                     STSGFKVLPPLIVHNDDGSYTPEIEEIYYGS"
     gene            complement(78400..78759)
                     /locus_tag="VXE25_000082"
     CDS             complement(78400..78759)
                     /locus_tag="VXE25_000082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000689596.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S1 RNA-binding domain-containing protein"
                     /protein_id="HEV0770623.1"
                     /translation="MKIGDKLKGRITGIQPYGAFVELETGDTGLIHISEIRTGFIENI
                     HETLKVDEEVQVQVVDLDEFTGKASLSIRTLEEEKYQFPRRRRFSSDRFNYGFAPFRR
                     MLPIWTGEALHHLKKKK"
     gene            complement(78761..80161)
                     /locus_tag="VXE25_000083"
     CDS             complement(78761..80161)
                     /locus_tag="VXE25_000083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional Cof-type HAD-IIB family
                     hydrolase/peptidylprolyl isomerase"
                     /protein_id="HEV0770624.1"
                     /translation="MDAKLRYKAKKIKIVFFDIDDTLRNSKTGFIPTTIPTVFKQLRE
                     KGILTGIASGRGIFGVVPEIRDLKPDFFVTLNGAYIEDKKGQVIYQHQIEKSDVEEYI
                     SWAKQEGIEYGLVGSHDAKLSTRTDMMSEAINPIYPDLDVDPDFHEKEDIYQMWTFED
                     KGDDLHLPDSLSDKLRMVRWHQHSSDIVPISGSKATGVEKVVEHLGLKPEKVMVFGDG
                     LNDLELFDYAGISVAMGISHDKIKEKADYITKTLEEDGIFDALEVFGMVEKELHFPQV
                     DIETVEGPLATIKTNHGDLRIKLFPEHAPKTVANFVSLSKDGYYDGVIFHRIIKDFMI
                     QGGDPTGTGMGGESIYGESFEDEFSEELYNIRGALSMANAGPNTNGSQFFIVQNQHLP
                     YSKKEITRGGWPEPIAEIYANQGGTPHLDRRHTVFGQLADEASYAVLDVIAAVETGAM
                     DKPVEDVVIETIEIED"
     gene            complement(80456..80695)
                     /locus_tag="VXE25_000084"
     CDS             complement(80456..80695)
                     /locus_tag="VXE25_000084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S18"
                     /protein_id="HEV0770625.1"
                     /translation="MAQQRRGGFKRRKKVDYIAANKIEYVDYKDTELLSRFVSERGKI
                     LPRRVTGTSAKNQRKVTTAIKRARVMALMPFVNED"
     gene            complement(80727..81197)
                     /gene="ssbA"
                     /locus_tag="VXE25_000085"
     CDS             complement(80727..81197)
                     /gene="ssbA"
                     /locus_tag="VXE25_000085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003083754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein SsbA"
                     /protein_id="HEV0770626.1"
                     /translation="MINNVVLVGRMTRDAELRYTPSNVAVATFTLAVNRTFKSQNGER
                     EADFINVVMWRQQAENLANWAKKGSLIGVTGRIQTRSYDNQQGQRVYVTEVVAENFQM
                     LERRSVREGHTGGAYSAPTANYSAPTNSVPDFSRNENPFGATNPLDISDDDLPF"
     gene            complement(81209..81499)
                     /locus_tag="VXE25_000086"
     CDS             complement(81209..81499)
                     /locus_tag="VXE25_000086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018030687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S6"
                     /protein_id="HEV0770627.1"
                     /translation="MAKYEILYIIRPNIEEEAKNALVARFDSILTDNGATVVESKTWE
                     KRRLAYEIQDFREGLYHIVNVEANDDAALKEFDRLSKINADILRHMIVKIDA"
     gene            complement(81652..82998)
                     /gene="asnS"
                     /locus_tag="VXE25_000087"
     CDS             complement(81652..82998)
                     /gene="asnS"
                     /locus_tag="VXE25_000087"
                     /EC_number="6.1.1.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000038477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparagine--tRNA ligase"
                     /protein_id="HEV0770628.1"
                     /translation="MMTKRVTIIDVKDYVGQEVTIGAWVANKSGKGKIAFLQLRDGTA
                     FFQGVAFKPNFVEKFGEEVGLEKFDVIKRLSQETSVYVTGIVKEDERSKFGYELDITD
                     IEVIGESQDYPITPKEHGTDFLMDNRHLWLRSRKQVAVLQIRNAIIYATYEFFDKNGF
                     MKFDSPILSGNAAEDSTELFETDYFGTPAYLSQSGQLYLEAGAMALGRVFDFGPVFRA
                     EKSKTRRHLTEFWMMDAEYSYLTHDESLDLQEAYVKALLQGVLDRAPQALETLERDTE
                     LLKRYIAEPFKRITYDQAIDLLQEHENDEDADYEHLEHGDDFGSPHETWISNHFGVPT
                     FVMNYPAAIKAFYMKPVPGNPERVLCADLLAPEGYGEIIGGSMREEDYDALVAKMDEL
                     GMDRTEYEFYLDLRKYGTVPHGGFGIGIERMVTFAAGTKHIREAIPFPRMLHRIKP"
     gene            complement(83014..83379)
                     /locus_tag="VXE25_000088"
     CDS             complement(83014..83379)
                     /locus_tag="VXE25_000088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HEV0770629.1"
                     /translation="MIDHFEIKVKDLQISEGFYRSFLAPLDYKLAFKTSSLISFLSPN
                     SPHPGGDFWLTQGTQDPVHFAFLAENKEEVQACYEAGLEAGGRDNGAPGYRSEHPIYY
                     AAFMIDLDGNNIEVVCHKE"
     gene            complement(83372..84559)
                     /locus_tag="VXE25_000089"
     CDS             complement(83372..84559)
                     /locus_tag="VXE25_000089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000777780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HEV0770630.1"
                     /translation="MKLSNRVLEMEESVTLAAGARAKALKAEGRDILSLTLGEPDFTT
                     PKNIQDAAIASIRDGRASFYTVTSGLPELKAAVNSYFERFYGYSVASNQVTVAAGAKY
                     SLYTFFMAAVNPGDEVIIPTPYWVSYGDQVKMAEGVPVFVSTKEDNHFKVTVDQLEAA
                     RTDKTKVLVLNSPSNPTGMIYTREELLAIGNWAVENDILILADDIYGRLVYNGHEFTP
                     ISSLSEAIRKQTVVINGVSKTYAMTGWRIGYAVGEADIIAAMSKIAGQTTSNPSAVAQ
                     YAAVEALSGEQDTVESMRQAFEERLNTIYPLLAEVPGFEVVKPQGAFYLFPNVKKAME
                     MKGYTDVTDFTTAILEEAEVALVTGAGFGAPENVRLSYATDLDTLKEAVERLKAFMGS
                     END"
     gene            complement(84556..85044)
                     /locus_tag="VXE25_000090"
     CDS             complement(84556..85044)
                     /locus_tag="VXE25_000090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000747178.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5590 domain-containing protein"
                     /protein_id="HEV0770631.1"
                     /translation="MKKRQNKAKNNLLWQYGLGMTILFVVISASFLYMVSLSMKPYQT
                     AKSEGEKLAQQYAGLEQADQVDLYNGLESYYSVLGRNKQQEALAVLIGKDDHKIYVYQ
                     LNQGVSQEKAETVSKEKGAGEIDKIIFGRYQDKPIWEVKSGSDFYLVDFETGALVNKE
                     GL"
     gene            85365..85913
                     /locus_tag="VXE25_000091"
     CDS             85365..85913
                     /locus_tag="VXE25_000091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000039625.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HEV0770632.1"
                     /translation="MSKKVLFIVGSLRQGSFNHQMALEAEKALAGKAEVSYLDYSALP
                     LFSQDLEVPTHPAVAAAREAVLVADAIWIFSPVYNFSIPGTVKNLLDWLSRALDLSDT
                     RGVSALQDKFVTVSSVANAGHDQLFAIYKDLLPFIRTQGVGDFTAARVNDSAWADGKL
                     VLEETVLNSLEKQAQDLVEAIK"
     gene            complement(86191..86919)
                     /gene="yaaA"
                     /locus_tag="VXE25_000092"
     CDS             complement(86191..86919)
                     /gene="yaaA"
                     /locus_tag="VXE25_000092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000697769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peroxide stress protein YaaA"
                     /protein_id="HEV0770633.1"
                     /translation="MKILIPTAKEMNTDLPSIEATPLKPESQAVLDALALYSASQLES
                     FYKVSAEKATEEFQNIQALKRQTAQHYPALKLFDGLMYRNIKRDKLTEAEQDYLENHV
                     FITSALYGVVPALSPMAPHRLDFLMKLKVAGKTLKSHWKAVYDEALKKEEVIFSLLSS
                     EFETVFSKEIRAKMVTFKFMEDRGGQLKIHSTISKKARGAFLTALIENQVQTVGEARR
                     LNFAGFVYREDLSQPQGLVFVKEV"
     gene            complement(86998..87162)
                     /locus_tag="VXE25_000093"
     CDS             complement(86998..87162)
                     /locus_tag="VXE25_000093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000508323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YczI family protein"
                     /protein_id="HEV0770634.1"
                     /translation="MGFYLMVASMLLGLLALKIGFSQFKEKKDKFLSILTSLAGIALV
                     LAAVWLGWPK"
     gene            complement(87329..88924)
                     /locus_tag="VXE25_000094"
     CDS             complement(87329..88924)
                     /locus_tag="VXE25_000094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000822862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0770635.1"
                     /translation="MKRIVFELIFIATTWYIFLPPLNLTSWEFLFFLCGHLLVVAILF
                     GFGKGINLVKTVHVRHGKAEAALNLEGFKINRLGKILLASIGGILLLAALVSLVTSSM
                     FQAKNYANVVTVTEKDFTEFPRSDTSKVPILDRSTAEKIGDRYLGSLTDKVSQYVAAD
                     TYTQLTIDGKPYRVTPLEYADPIKWFNNQAKGIGEYIKVDMVTGNADLVDLKTPIKYS
                     DSEYFNRDVKRHLRLKYPTKIFKTPSFEVDDEGNPFYVATVYQKQFGLAVPRPASVII
                     LDATNGETKEYSLSDVPEWVDRIYPAEETIEQINYNGKYKDGFLNAMISKKNVTQTTK
                     GYNYLSIGNDIYLYTGVTSANADESNLGFILENMRTGEITKYSLASATEESARESAEG
                     AVQEKSYKATFPILINLNDKPLYIMGLKDNAGLVKEYALVDAVEYQNVIVATTVEEML
                     SKYANKNDLEIDNATTESINGVVADLKSAVIKGDTVYFFKVDGKIYKVKASVSDDLPY
                     LENGKTFEGQVGKDNYLKTFKVQ"
     gene            complement(88936..89346)
                     /locus_tag="VXE25_000095"
     CDS             complement(88936..89346)
                     /locus_tag="VXE25_000095"
                     /EC_number="3.5.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000412213.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide deformylase"
                     /protein_id="HEV0770636.1"
                     /translation="MEKKIVKDILFLSQVSQPASQEDLYLARDLQDTLLANHDTCVGL
                     AANMIGVQKRVIIFNLGLVPVVMFNPVLLSFEGSYEAEEGCLSLVGVRSTKRYETIRV
                     AYRDSKWQEQTITLTGFPAQICQHELDHLEGRII"
     gene            complement(89462..90253)
                     /gene="yghU"
                     /locus_tag="VXE25_000096"
     CDS             complement(89462..90253)
                     /gene="yghU"
                     /locus_tag="VXE25_000096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001277405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutathione-dependent disulfide-bond
                     oxidoreductase"
                     /protein_id="HEV0770637.1"
                     /translation="MSAYQLPTVWQDEASNQGAFTGLNRPTVGARFEQNLPKGEQAFQ
                     LYSLGTPNGVKVTILLEELLEAGFKEAAYDLYKIAIMDGDQFGSDFVKLNPNSKIPAL
                     LDQSGTEDVRVFESAHILLYLAEKFGAFLPSNPVEKVEVLNWLFWQAGAAPFLGGGFG
                     HFFNYAPEKLEYPINRFTMEVKRQLDLLDKELAQKPYIAGNDYTIADIAIWSWYGQLV
                     QGNLYQGSAKFLDASSYQNLVKWAEKIANRPAVKRGLEVTYTEIK"
     gene            complement(90266..92962)
                     /locus_tag="VXE25_000097"
     CDS             complement(90266..92962)
                     /locus_tag="VXE25_000097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation-translocating P-type ATPase"
                     /protein_id="HEV0770638.1"
                     /translation="MSKEQKRQAFYTQSPEEVLQAVDATEQGLSSSEAEKRLAEFGHN
                     ELEEGEKRSILVKFIEQFKDLMIIILVAAAILSVVTSGGEDIADAIIILAVVIINAAF
                     GVYQEGKAEEAIEALKSMSSPVARVLRDGHMAEIDSKELVPGDIVALEAGDVVPADLR
                     LLEANSLKIEEAALTGESVPVEKDLSVELATDAGIGDRVNMAFQNSNVTYGRGMGVVV
                     NTGMYTEVGHIAGMLQDADETDTPLKQNLNNLSKVLTYAILVIALVTFVVGVFIQGKN
                     PLGELLTSVALAVAAIPEGLPAIVTIVLSLGTQVLAKRHSIVRKLPAVETLGSTEIIA
                     SDKTGTLTMNKMTVEKVFYDAVLHDSADDIELGLEMPLLRSVVLANDTKIDVEGNLIG
                     DPTETAFIQYALDKGYDVKGFLEKYPRVAELPFDSDRKLMSTVHPLPDGRFLVAVKGA
                     PDQLLKRCLLRDKAGDIAPIDEKVTNLIHTNNSEMAHQALRVLAGAYKIIDSIPENLT
                     SEELENDLIFTGLIGMIDPERPEAAEAVRVAKEAGIRPIMITGDHQDTAEAIAKRLGI
                     IDANDTEDHVLTGAELNELSDEDFEKVVGQYSVYARVSPEHKVRIVKAWQKQGKVVAM
                     TGDGVNDAPALKTADIGIGMGITGTEVSKGASDMILADDNFATIIVAVEEGRKVFSNI
                     QKTIQYLLSANTAEVLTIFLSTLFGWDVLQPVHLLWINLVTDTFPAIALGVEPAEPGV
                     MNHKPRGRKASFFSGGVLSSIIYQGVLQAALVMSVYGLAIAYPVHVGDNHAIHADALT
                     MAFATLGLIQLFHAYNVKSVYQSILTVGPFKSKTFNWSILVSFILLMATIVVEPLEGI
                     FHVTKLDLSQWGIVMAGSFSMIIIVEIVKFIQRKLGFDKNAI"
     gene            93266..94450
                     /gene="mntE"
                     /locus_tag="VXE25_000098"
     CDS             93266..94450
                     /gene="mntE"
                     /locus_tag="VXE25_000098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000813920.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDF family manganese efflux transporter MntE"
                     /protein_id="HEV0770639.1"
                     /translation="MKQSISNLKLAERGAIISISTYLILSAAKLAAGHLLHSSSLVAD
                     GFNNVSDIIGNVALLIGIRMARQPADRDHRFGHWKIEDLASLITSIIMFYVGFDVLRD
                     TIQKILSREETVIDPLGATLGIISAAIMFVVYLYNTRLSKKSNSKALKAAAKDNLSDA
                     VTSLGTAIAILASSFNYPIVDKLVAIIITFFILKTAYDIFIESSFSLSDGFDDRLLED
                     YQKAIMEIPKISKVKSQRGRTYGSNIYLDITLEMNPDLSVFESHEIADQVESMLEERF
                     GVFDTDVHIEPAPIPEDEILDNVYKKLLMREQLIDQGNQLEELLTDDFVYIRQDGEQM
                     DKEAYKTKKELNSAIKDIQITSISQKTKLICYELDGIIHTSIWRRHETWQNIFHQETK
                     KE"
     gene            complement(94593..96464)
                     /locus_tag="VXE25_000099"
     CDS             complement(94593..96464)
                     /locus_tag="VXE25_000099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001279112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HEV0770640.1"
                     /translation="MSDFIVEKLSKSVGDKTVFRDISFIIHDLDRIGLIGVNGTGKTT
                     LLDVLSGVSGFDGDVSPFSAKNDYQIGYLTQDPDFDDRKTVLDTVLSSELKEIQLIRE
                     YELIMLDYSEDKQARLERVMAEMDSLQAWEIESQVKTVLSKLGIQDLSTPVGELSGGL
                     RRRVQLAQVLLGNHDLLLLDEPTNHLDIAIIEWLTLFLKNSKKTVLFITHDRYFLDAL
                     STRIFELERAGLTEYQGNYQDYVRLKAEQDERDAALLHKKEQLYKQELAWMRRQPQAR
                     ATKQQARINRFHDLKKEVSGSSAETDLTMNFETSRIGKKVIEFQDVSFAYENKPILQD
                     FNLLVQVKDRIGIVGDNGVGKSTLLNLIAGSLESTKGQVVIGETVRIAYFSQQIEGLD
                     ESKRVINYLQEVAEEVKTSGGSTTSIAELLEQFLFPRSTHGTLIEKLSGGEKKRLYLL
                     KLLLEKPNVLLLDEPTNDLDIATLTVLENFLQGFAGPVLTVSHDRYFLDKVATKILAF
                     EDGKIRPFFGHYTDYLDEKAFETDMANQVQKAEKEKVVKVREDKKRMTYQEKQEWASI
                     EGDIETLEKRIAAIEEEMQANGSDFGKLATLQKELDEKNEALLEKYERYEYLSEFDS"
     gene            complement(96461..97645)
                     /locus_tag="VXE25_000100"
     CDS             complement(96461..97645)
                     /locus_tag="VXE25_000100"
                     /EC_number="2.7.7.72"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001138849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CCA tRNA nucleotidyltransferase"
                     /protein_id="HEV0770641.1"
                     /translation="MPSEFQKALPVLEKIKEAGFEAYFVGGSVRDALLHSPIHDVDIA
                     TSSYPEETKQIFPRTADIGIEHGTVLVLDGDEEYEVTTFRTEDVYVDYRRPSAVSFVR
                     SLEEDLKRRDFTVNAFALDETGEIVDLFHGLEDLEKQVLRAVGVASERFNEDALRIMR
                     GFRFQASLGFALEPETFKAMKTLTPLLEKISVERTFVEFDKLLLAPFWRRGLASMIES
                     QAYDYLPDMASSQDKLNRLFDLETDFTFESSEQAWAALLWALEIENAQSFLKSWKTSR
                     QFAKQVQDLLIILALRENGELSKRDCYRFDIDLLLQAENLRQAQGKEVNLQAITEKYQ
                     SLTIHDKKEIQINGDILIKEYGYQPGPDLGEILTEIEFAIVDGELENNREAIHAYLRE
                     KK"
     gene            complement(97657..98424)
                     /locus_tag="VXE25_000101"
     CDS             complement(97657..98424)
                     /locus_tag="VXE25_000101"
                     /EC_number="1.17.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002897644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate reductase"
                     /protein_id="HEV0770642.1"
                     /translation="MSIRVIIAGFKGKMGQAACQMVLTDPDLDLVAVLDPFESESEWQ
                     GIPVFKDKADLAGFEADVWIDFTTPAVAYENTRFALENGFAPVVGTTGFTSEEIAELK
                     EFSRAQDLGGLIAPNFALGAVLLMQFATQAAKYFPNVEIIELHHDKKKDAPSGTAIKT
                     AELMAEVRESIQQGAADEEELIAGARGADFDGMRIHSVRLPGLVAHQEVIFGNQGEGL
                     TLRHDSYDRISFMTGVNLGIKEVVKRHELVYGLEHLL"
     gene            complement(98690..99538)
                     /locus_tag="VXE25_000102"
     CDS             complement(98690..99538)
                     /locus_tag="VXE25_000102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000762171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HEV0770643.1"
                     /translation="MKLAVFTDSSAYLSAEILQREDLFVLDIPVNIDGEEYVEGINLS
                     AEEFYQKMAQASELPKTSQPSIAKLDEILTSLKEQGYTHALGLFLSSGISGFYQNIQY
                     MVDDYEGLTIAFPDTLITSAPLGIMVESVFNWRDQGDDFASIQDKLAIQISRTSAFIM
                     VDDLDHLVKGGRLSNGAAILGNLLSIKPILYFNDQGVIEVYEKVRTEKKATKRLIEII
                     KETTASGQYRVIVIHGNAPEKAEELRQHLLDFGLGSDVSLATFGSVIGTHLGAGSIAL
                     GYIPVI"
     gene            complement(99540..99914)
                     /locus_tag="VXE25_000103"
     CDS             complement(99540..99914)
                     /locus_tag="VXE25_000103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001050081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1149 family protein"
                     /protein_id="HEV0770644.1"
                     /translation="MNLKREQEFVSQYHFDARNFEWENENGAPETKVDVNFQLLQHDQ
                     ENQVTSLIVILSFMIVFDKFVISGTISQVNHIDGRIVNEPSELNQEEVETLARPCLNM
                     LNRLTYEVTEIALDLPGINLEF"
     gene            complement(99988..101340)
                     /locus_tag="VXE25_000104"
     CDS             complement(99988..101340)
                     /locus_tag="VXE25_000104"
                     /EC_number="5.4.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglucosamine mutase"
                     /protein_id="HEV0770645.1"
                     /translation="MGKYFGTDGVRGEANLELTPELAFKLGRFGGYVLSQHETEAPKV
                     FVGRDTRISGEMLESALVAGLLSVGIHVYKLGVLATPAVAYLVETEGASAGVMISASH
                     NPALDNGIKFFGGDGFKLDDEKEAEIEALLDAEEDTLPRPSAEGLGILVDYPEGLRKY
                     EGYLVSTGTPLDGMKVALDTANGAASTSARQIFADLGAQLTVIGETPDGLNINLNVGS
                     THPEALQEVVKESGSVIGLAFDGDSDRLIAVDENGDIVDGDKIMYIIGKYLSEKGQLA
                     QNTIVTTVMSNLGFHKALNREGINKAVTAVGDRYVVEEMRKSGYNLGGEQSGHVILMD
                     YNTTGDGQLSAVQLTKIMKETGKSLSELAAEVTIYPQKLVNIRVENVMKEKAMEVPAI
                     KAIIEKMEEEMAGNGRILVRPSGTEPLLRVMAEAPTTEEVDYYVDTITDVVRAEIGID
                     "
     gene            complement(101364..102143)
                     /locus_tag="VXE25_000105"
     CDS             complement(101364..102143)
                     /locus_tag="VXE25_000105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397683.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0770646.1"
                     /translation="MKKNSLYIISSLFFACVLFVYATATNFQNSTSARQVKTETYTNT
                     VTNVPIDIRYNSDKYFISGFASEVSVVLTGANRLSLASEMQESTRKFKVTADLTDAGV
                     GTIEVPLSIEDLPNGLTAVATPQKITVKIGKKAQKDKVKIVPEIDPSQIDSRVQIENV
                     MVSDKEASITSDQETLDRIDKIIAVLPTSERITGNYSGSVPLQAIDRNGVVLPAVITP
                     FDTIMKVTTKPVAPSSSTSNSSTSSSSETSSSTKATSSKTN"
     gene            complement(102130..102987)
                     /locus_tag="VXE25_000106"
     CDS             complement(102130..102987)
                     /locus_tag="VXE25_000106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001867651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR00159 family protein"
                     /protein_id="HEV0770647.1"
                     /translation="MNFQQLSNLQYWTSLFASPWTIAINLIDILIVAYILYHFTKAIA
                     GTKIMILVRGVLVFILAQILANMIGLTTISWLINQIITYGVIAAVVIFSPEIRTGLER
                     LGRATDFFSNAPISAEEQMIRAFVKSVEYMSPRKIGALVAIQRVRTLQEYISTGIPLD
                     AKISAELLINIFIPNTPLHDGAVIIKEERIAVTSAYLPLTKNTGISKEFGTRHRAAIG
                     LSEVSDALTFVVSEETGGISITYNGRFKHNLTLDEFETELREILLPKEEVGLSFKERL
                     LGGWKHEKK"
     gene            103123..104091
                     /locus_tag="VXE25_000107"
     CDS             103123..104091
                     /locus_tag="VXE25_000107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000081018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HEV0770648.1"
                     /translation="MSQLYDITIVGGGPVGLFAAFYAHLRQAKVQIIDSLPQLGGQPA
                     ILYPEKEILDVPGFPNLTGEELTNRLIEQLNGFDTPIHLNETVLEIDKQEEEFAITTS
                     KGSHLTKTVIIAMGGGAFKPRPLELEGVEGYENIHYHVSNIQQYAGKKVTILGGGDSA
                     VDWALAFEKIAPTTLVHRRDNFRALEHSVQALQESSVTIKTPFAPSQLLGNEKTLDKL
                     EITKVKSDETETIDLDHLFVNYGFKSSVGNLKNWGLDLNRHKIIVNSKQESSQAGIYA
                     IGDCCYYDGKIDLIATGLGEAPTAVNNAINYIDPEQKVQPKHSTSL"
     gene            complement(104344..>104457)
                     /locus_tag="VXE25_000108"
     CDS             complement(104344..>104457)
                     /locus_tag="VXE25_000108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="autolysin"
                     /protein_id="HEV0770649.1"
                     /translation="AFIQSADGTGWYYLKPDGSMADKPEFTVEPDGLITVK"
BASE COUNT        30589 a        23324 c        19238 g        31306 t
ORIGIN      
        1 ctccatgaat gatagatacc ttgttatgac gcgcttacta tattagaaag ttggctctct
       61 aattaaatta attctcatta tatatatcaa aagaccgcag tttgaaaact acggtctaat
      121 tttttgtcca aatgtaaatc acttggaact attattcaat ttattctttt tagtaaatgt
      181 tcccgtttta atcccagtta cagtttttaa tcctctgtaa ccgttgattt tacaaagctt
      241 ttaatttttt tgcgattact cccactcaac tgttgcaggt ggtttacttg taatatcgta
      301 gacgatacgg ttaacatgat ccacttcatt tacgatacgc actgagattt tttgaagtac
      361 ttcccatgga attttggcaa aatcagcagt cataccatcg atagaagtga tagcacggat
      421 tgcaatcgtg tagtcatacg tacgaccgtc acccataaca ccgactgaac gaacgcctgt
      481 gttaacagtg aagtattgcc aaatatcgcg gtcaagtcca gctttagcga tttcttcacg
      541 aagaatagcg tctgattcac gaacggtttc aagtttctct tcagtgattt cacccatgac
      601 acggatagca agtcctggtc ctgggaatgg ttggcgccat acgatatggt ctggcatacc
      661 aagctctgta ccaagagcac gaacttcatc cttgtaaaga gtattgagtg gttcaatcaa
      721 ttcaaactgc atatcttctg gaagaccacc cacgttgtgg tgtgacttga tagtttgagc
      781 tgtatccgta ccagactcga taacatctgt atataaagta ccttgagcaa ggaatttcac
      841 atctttgagc ttgcttgctt cgtcatcgaa tacatagaca aactcgttac caatgatttt
      901 acgtttttgt tcaggatcag aaacgccagc aagtttgtca aggaaacgtt tagcagcgtc
      961 tgctttgacg atattcaaac caaacttacc accgagcatg tccataactt gatcagcttc
     1021 gcctttacga agaagaccgt ggtctacgaa gatacagatc aattgatcgc caatcgcttt
     1081 ttggagaaga accccaacga cagatgagtc aacaccacct gatagaccaa gaaggacacg
     1141 tttatcaccg acggtttcac gaattttttt gatctgcatg tcaatgaaat tatccattga
     1201 ccagtcacct ttagccttac aaatgttaag ggcaaagtta cgaaggatat catttccgta
     1261 tacagaatga cgaacttctg ggtggaattg gataccgtaa atgtgtttat ctgggttttc
     1321 gatggctgcg tatgggcagt cagctgatgt acctgtacga acaaagtcag caggaatctc
     1381 agtaaccgca tcaccatggc tcatcaaaac agtctgttca tcaggtgttg attcaaaaag
     1441 cgctgatggt gtgtgagtta gggttgattg accgtattca cgatttccag catcacctgc
     1501 aggaacaact tttcctccaa gtttatgggt caataactgc ataccataac agattcccaa
     1561 aattggaatt ccgagttcga agatttctgg gtcaatatca aatgaaccat cttcatatac
     1621 agaatttgga ccacctgata gaataattcc tacaggattg acttcacgaa cttcagcagc
     1681 tgaaatttta tggcttttta gttctgaaaa aacaccaatc tcacggatac ggcgtgaaat
     1741 cagctggttg tactggctac catagtccaa tacgatgatt ttttctacat cttgcaaatc
     1801 agttgaaatg ttgctcatct ttttcctttc tcaaaagaaa tatcttttct caatattcta
     1861 tcacaaataa gggcgaatta ccaactaaac aaggcgaagt ttgacttttt ctagtttatt
     1921 ggggtacaat agagaaaaga tagaaatgaa gtgaaaaata tgctacctgc ttatatgaaa
     1981 atccatgatc agataaaaaa ggatattgac gagcaccgtt gggctattgg tgagaggctt
     2041 cccagtgaaa gagatttagc tgagcagttt gcggtcagtc gcatgaccct ccgccaagcc
     2101 gtatctctat tagtcgaaga aggcgtctta gagcgccgtg taggaagcgg cacctttgtt
     2161 tccagtactc gagtacaaga aaagatgcga gggacaacca gttttactga aattgtcaaa
     2221 tcccaaggta aagttccctc tagccagctc atttcctaca aaaaaaccat tcccaatgag
     2281 caagaagttg ccaagctagg aatttttcca acggacaata ttatccgaat ggagcgggtc
     2341 cgctatgccg accaagttcc cctagtttat gaagttgctt ctattcctga aaaattcatt
     2401 aaggacttta aaaaagaaga aatcaccagt catttcttcc aaaccttgca aaaacatggc
     2461 tatcgtatcg gtaaatccca acagaccatc tatgctcgcc ttgctaaaga aaagattgcc
     2521 cactatttgg aagttgaaaa aggacatgct attcttggat tgacccagat ttcctaccta
     2581 gaagatggta ctgcttttga atacgtaaaa agtcaatatg taggcgaacg ctttgaattt
     2641 tatcttgaaa ataattagat taccacgcaa aaactctctg tcacggacaa agagtctttt
     2701 ttatttttct aagaataaat ctttcaaaga aatcaaagtt acagcaaaca atatcattgc
     2761 cataccaaga aaatcaatgg gataaaattg ttcattcatt attaagaagg caaagaaaat
     2821 cgccgatatt ggctcaattg aagccaacaa gcttgacttg accggtccta tcagactggc
     2881 tcctttaagg aaagctgtat aggcaaagac agtcccgata aggataatgc ctgcaaacgc
     2941 aaggagaaaa tcaagactag tcgggatatc ggcctgtaga acccctgtaa aaggaagggc
     3001 gaccaaacct gctatgacca ttcccacacc aatgaccaag ctgctccccc actttttaat
     3061 caaggctatg ggtaaaatga tatacagagc ataagtcaag gcagaaaaga gaccccagaa
     3121 cagaccagca ggtgtcatgg ataactggtc caactgccca tgtgttgcga tcaggaaggt
     3181 tcctccgatg gcgaatatga tggaaactat ctctcccagt gtcggtgcca ccctatcctt
     3241 gatacagcta taaattaaaa ttccgacagg acaaacatac tgaagcaccg tcgctgttcc
     3301 cgcattggtc tcctgaatag cagacagata ggcgaattgg ttgagaaaaa gaccaatcag
     3361 agcaaaaata agaagagaca gcaaactctt tctatccttt aaaaagacca gtattttatc
     3421 ctttgcagta gcataagcca agagcatgag aattccacca gcgattaaaa gacgcaagtt
     3481 agtcaagacc agagccgaaa ttccgtgtgc cattaggtat tggccactcg ttcctgacaa
     3541 cccccaagca ataccagcca caactgttag taaagtccct tttaaactat ttgacatgtc
     3601 tctccttact cttctttgcg aatcaagttc atcacttgat tgcggtctaa tatccattga
     3661 gctctctcgt ccttttcata ggtacgattc gataggaaaa tagtggcttc ttgcttctga
     3721 cgattccaca tgataaaggt acctgtatag cccgtatggt ctagccaatc tccttccaaa
     3781 ttccatgcta aagaacgttc cttgtcatcc aaaggagaaa aattttgatt taagtctctt
     3841 gcaaaatcat ctgctaaata gtgttctaaa aagatttgta aatcctttat agtcgaaaat
     3901 aaaccagcac tcccagcatg tctacccagg agacgagcct tgggatcatg cactatgcct
     3961 gcctctacac ctctaactgt tggaacagca agctcaactg gcccaaactt ggtttccgtc
     4021 attccccaag gtttccagac ttgatccttt aaaatcacat ccaaatcttg attaaaaatt
     4081 ctttccaaaa taaagcccaa cagcaaaaaa tggacatccg aataaagaaa ggctggctga
     4141 cttcgtctgt tgagatgaaa catcgcttcc tttaattcag gggctgttaa aagatcacga
     4201 ttaggaataa aaggatcaag gtctgttgca tgagtcaaga gctggcgaat agtgatgtct
     4261 ggataatcac tctcaggtaa aaaatctatt accagtctat caatatctaa ttgacctatt
     4321 tcccacaaga aggtacaaac tgtgccaacc ccaacaacct tgctgacact agctaggtca
     4381 taaactagtc ctgcctcagt ctgcaagcca tgctctgggt cactctggcc taaatagaac
     4441 tctgtccatt gattgtcctt aaaatacgca aaagaggctc cgggataaat ccctgcctcg
     4501 atttgttctt ctattttttt aataatcttg gtccacttca tacttcttca aaccacaatt
     4561 caacattatt tctatcttta ccaaggaaga atttttcaga cttaggaata aaatattcag
     4621 tagactcaaa cttctggcga agacttgcta tgtctaattc attgaccaag aacttgagca
     4681 tagataagtc ccaggtaacc gtattgtcca cagtcaaatc ctgcccctga gctggaataa
     4741 aatcaaggga tgccccaatt tcagatgatt ccaagaaact ttcgatatca gttgggagat
     4801 gtaattccat agaaatctca aatttactta aagaaattga tgccaaatct gtttgaaatt
     4861 caggcttttc tcctacttct actagacttg ctatgtcatc ttccgcatga atcaaaatca
     4921 aatcatcttc tggtgagaaa atttcaaaag cgtagccatt ttgaccttta tataatcgat
     4981 gaatcgaatc tgttttagat aagattcctt caatttctaa gggattttcc accttgacaa
     5041 tcaatctagc tagttttttt cttccctcta ccttacgagt acgcatactg ggagcttctt
     5101 ctaaaaccag cttttcaaga cccgtttggt cacctagtga cagaaaggcc gattcttcta
     5161 acaaggcctt cattccaagg gtttcaatat aaaatgtttc atttaatttt ctattattag
     5221 cttttaaagt aggaataatc cgtacaatct gatttacatt cataaattcc tccgtcactt
     5281 tttattttaa aggattttag aattttttac aagatattat gctcaaattt aacattattt
     5341 agctatttag taaagatagt ctttcaagga ttttgacaaa gcctgataac cagcaatact
     5401 gaggtgcagt ccatcagttg tatattcttt tttgagttgg cctgcttggt ctgtcaaaca
     5461 atcaaatact ggcacaaatt ccacctgcat ataggcagat gcaagctctt gataggcttg
     5521 attccagttc tgaatttttt cattcgagcg gatatagact gcctgctggt actcctctct
     5581 ctcattgaca ggcaaaatgg aaagcaattt aatctctgtc aatggataat cgcgagcaac
     5641 ggattgaatg atagcttcga gattattgag agcctcattc acaggaacat cctttccgat
     5701 atcatttgtc ccaatcagaa gaaaaatttt atctactgct ccaccatata gatgagcatc
     5761 aaggttctct agtaacagtc ctgtctgata gccacgaatt cctcgattga caatcgtctt
     5821 tgaagtccca aatagctcct gtagaggata atactcgaca atggaatccc caataaaaag
     5881 aatgtttggt tctacaacag aaatgtgatt taggtgacga tacttagttt gaattttttc
     5941 ttgttccttt aggagccaat tttctaataa ctgtactgcc acttcattct cctttttcta
     6001 accagttttc caagacttga taaactcctc cttggctgtt ggctggtgct agagcagtcg
     6061 ccacagcttt ggctttctca tcagcatttt ccatcgcata ggcaattcca gccatttcaa
     6121 gcatttcaac atcattttca ctatcaccaa aagccatgat ttcttgggat ttcaagtccc
     6181 agcgcttgag taattcctcc aagccccatg ctttatgaat cccagcttgg aggatatcaa
     6241 tgcaaccata gccactggat acagctcgga cacggccatc aaagagagca ttgatttctt
     6301 ccaaaaccga actcaaacgt tcctcaccaa caaccatgct catcttgagc acaccaccaa
     6361 agaggtcaga tgttaattca tccacaaatt gcatccgttg gtagaatttt tcaatcattt
     6421 ctggagtcat aaaactttca agatctgtaa aaatcgtacc ttccttgaca aaatcaccct
     6481 tcatccccgt tacaacaaac tggtcctgac acgctcgacc cttgaaatga gtcaaagcct
     6541 tgttgacaat ggcgtcatcc catgtctgag cctgaatcaa ttcattgttt tcaaaaatac
     6601 gagcgccatt agcaacaacc agaaccactc gatccaccaa gggactcagt agttgtctca
     6661 tgcggtgaat ttcattgccc gtcgcaatga caaaacgaat gcccctttga tccaactgat
     6721 ctaaaatctt ttccaatcgt gggagatcaa gctgacctct agcatccagc aaggtcccat
     6781 ccatatctgt cgcaattacc ttaatcatca tttactttcc tctggattca agctaatacc
     6841 acttcaatcc cacatgttca ttcatttctt tataggctgt atcaattcgt tccttagtcg
     6901 cttcatctaa ctggtcacga tgactgccat cctctataaa atcttccaaa atataagttt
     6961 ggtaatgata caagggatat ccttctggtg aaaaggttcc ctttggtgtt cgattgaccc
     7021 aagtaggatg agctttagct gttccgatag ttgtttttcc atccttcttc ttgatggtga
     7081 catccatgag aacaccacgt tcagtccact tagcattctc ttcatctccc atagattcaa
     7141 ttcgttgatt ggaaatgaag ttccccattt aatagataat gagtttctta tctccatctt
     7201 tttcaaccgt ttcagatggt tcaacaacgt gaggatgccc tccaaagata atatccgctc
     7261 ccaaatcgat catcttgtga taaagagctt tttgttcttc agttggttcc aatcgatact
     7321 caacacccat ctgaagcatg ataatggtga tatctgcttc cttctctgcc cgttcaattt
     7381 caacctttat cttatcttcg tttaaatatg aaagataacg attatagtct tcctgagaaa
     7441 tatactgctc aattccattg aaaccatagg aataggctaa caatgcaacc ttgataccat
     7501 tcacttcctt aatgaccagc ggagcctgat cacgtggttc gtgcgtataa actccgattg
     7561 gagtgattcc agctttctca ataatatcgg ccgttgaaat aactccctca atttgcgaat
     7621 ccaaaatatg attatgagct aaatccagca catgataacc tgcctcctta atagcatcca
     7681 taacttcaac aggagcatta aagagaagat aacccgctaa ataatgatcc ttattaatgg
     7741 ttccttcaaa atcaccaata gctaaatctg ctgcttagtc cccttgcttg agccaaggag
     7801 tcacatactc aaaattttca tgaaagtcat aggtaccgtc ttctttttta gctgaaaaga
     7861 aaagtccatc gtggtagagc aaatccccgt gggccataat tctggcagtt ttttcctctt
     7921 cctactcctg agacttttgc ttagtcccct cttgagaaat agtatctcgt ttttgactag
     7981 tcaagggatt ccttggaagc tttcaaacaa caagaccaag cccattgata aaccaactgc
     8041 tagcaagagt atcgccacaa atcccttatt gctccacttg cgataactcc taaaaagttt
     8101 accaagccct tcataaaacg aaaagctaaa ccaccctgat ttcgattttg tcttctttgt
     8161 atcttcgttc tccctacttt cttatgcaag ccttttcttt ttattatatc acagataagt
     8221 atttctttca caattgaatt gaacttccca tctattttct ataaatccta aatgccataa
     8281 tgctttcaat tcttgtcatt ttgtgatatc atgtagagga aatgaactaa tccacagtgg
     8341 cttattccaa gtataccact tgggctttgg cagtagctaa ctgcactaaa cataatataa
     8401 ggagagaaaa tgtctgcaat agaacgtatt acaaaagctg ctcacttaat tgatatgaac
     8461 gatattatcc gtgaagggaa tcctactcta cgcacggttg ctgaggaagt cactttcccc
     8521 ctatctgacc aggaaatcat cctaggcgaa aagatgatgc aattccttaa acattcccaa
     8581 gatcctgtca tggctgaaaa aatgggactc cgcggtggtg ttggactggc tgctccccag
     8641 ttagatatct caaaacgcat tatcgctgtt ttggtaccta atattgttga agaaggcgaa
     8701 actccacagg aagcctacga tttggaagcc attatgtaca atccaaaaat cgtctctcac
     8761 tctgttcaag atgctgctct tggcgaagga gaaggttgcc tgtctgttga ccgtaacgtg
     8821 cctggctatg ttgttcgcca tgcccgcgtt actgttgact actttgacaa agatggagaa
     8881 aaacaccgta tcaaactcaa aggctacaac tccattgttg ttcagcatga aattgaccac
     8941 attaacggta tcatgtttta cgatcgcatc aatgaaaaag acccatttgc agttaaagat
     9001 ggtttactga ttcttgaata aagaaaatcc cgttgcaaga cggggttttg tgttataata
     9061 gaggcatgaa aacaaatgat attgtctatg gtgtccacgc cgttaccgaa gctctccttg
     9121 caaatacagg aaacaaactc tacctccaag aagatctccg aggtaagaat gttgagaaag
     9181 tcaaggaact agctacagaa aagaaggtgt ccatttcttg gacatcaaaa aaatctctct
     9241 ctgagatgac tgaaggtgct gttcatcaag gttttgttct acgagtgtct gaatttgcct
     9301 atagcgagct agattacatc cttgcaaaaa cacgccaaga agaaaatcca cttctattga
     9361 ttctagatgg tctaaccgat ccccataatc tgggttctat cttgcgaaca gccgatgcga
     9421 ccaatgtttc aggtgtcatc attcccaagc accgtgctgt cggagtaact cctgtcgttg
     9481 ccaaaacagc cacaggtgct attgaacacg ttccaattgc ccgagtgaca aacctcagtc
     9541 aaaccttaga taaactcaag gatgaaggct tctggacctt tggaacggat atgaacggta
     9601 ctccttgcca caagtggaat acaaaaggga aaatcgccct catcattgga aatgaaggaa
     9661 aaggtatctc tagcaacatc aaaaaacaag tcgatgagat gattaccatt ccgatgaatg
     9721 gacatgttca aagccttaat gccagtgttg ctgcggccat tctcatgtac gaagttttcc
     9781 gaaatagact ataaaaaagt ttccagtcat ctgattggaa acttttttat gattaactat
     9841 gttctgtgat aaacttgtag gcttcttgac cagcgatagc tccatctcca actgctgttg
     9901 ttacttggcg aaggtctttc aagcgaacat ctccaactgc aaagataccg tcgactgcag
     9961 tcttcatgtg gctatctgtc acaatccagc ctgcctgatc ttggatattc aattctttaa
    10021 caaaatcgct aagagggtcc aaaccaacat agataaagac accaccgaag gcttgttctg
    10081 tcacttgacc tgttttcaca ttttcaaata cgactgattc tactcggttt tcacccttga
    10141 tttcccttac tacagaatcc cagataaagc tgattttttc attcgcaaag gcgcgatctt
    10201 gtaaaacctt ttgggcacga agttggtcac gacggtgaac aatggtaaca gtcttagcaa
    10261 aacgagtcaa gaagagggct tcttcaacag ctgaatctcc accaccaact atcaataaat
    10321 cttggtcacg gaagaaagca ccatcacaca cagcacagta agaaacacca cgactgttca
    10381 gttcttcttc tccaggcact cccaaaggac ggtgtttaga accagttgct acgataactg
    10441 tacgtgtttc atatgtttgg tcatcagtca tcactttctt aaaatcacca tggtcttcga
    10501 cattttcaac ataaccataa atgtgctcaa caccaagatt ttcaagtggt tcaaacatct
    10561 tttcagccaa ttcaggtcca ctaatattag cgtatcctgg gtaattttcg atatcagatg
    10621 tattattcat ctgaccacct ggcagaccac cttcaatcaa agctactttt agattgcttc
    10681 gagcagcata caaggccgca gtcatccctg caggtccagc accgataata atagtatcgt
    10741 acatatagat tccttctttc ttgttgtaac tatctttatt ctaactcttt cttgtcaatc
    10801 acgcaaggat tatgccttga aaacaagaat taaactcata accgcaaagg ataatactgg
    10861 gacaaccaag actccaatca taatcatatc atagagatgg gcttggcgag ccttggctgt
    10921 cttatcaact cccgacatgg ctctcagacc aatccaaatc cctaaaaaaa tcagaacaag
    10981 gatggtggtc aatatcaaac tctcgaaata taaagaaaat agttgcagta gcatgatttc
    11041 tctcatttct atctttttta aagagtaaac tcagctagtc caactaactg agttttcctt
    11101 tatctattat atcaaatata agtccgtttg taactagcga agaattcttt tgtccgctct
    11161 tctttagggg tgtggataat ctcatccgga gttccagact cgatgatttt ccccttatct
    11221 aagaagagaa tcttatccgc aacttgggct acaaaggaca tgtcatgact gaccaaaatc
    11281 atggtctgac ctgacttagc agcatctgca atagactttt ctacttcacc gaccaattct
    11341 gggtcaaggg ctgaagttgg ttcgtctaag agcaaaacat ctggtttcat agcaagcgca
    11401 cgcgctaggg caacccgttg cttctgtcca cctgataaat ggcgaggata atggttttca
    11461 cggtccgaaa gcccaacctt agccaactct tccttggcaa tcttagtcgc ttcttggtca
    11521 gataatttct tgacaacaac caagccttct ttcacattat caagtgctgt tcggcgttca
    11581 aacaaattaa actgttggaa aaccatagac aacttacggc gtagggcaag gatttcttct
    11641 tgagtgattt tagaaaaatc aactgaaaaa ccatcaatct gaatagagcc actgtcaggt
    11701 gtttcaagat aattgagact gcgaagaaag gttgattttc cagctcctga agaaccaatc
    11761 aaggctacaa cttccccttt ttgaatatcc aagtccagat gatccaagac agtctgtcct
    11821 gaaaaggatt tgcttaaatt cgaaatctta atcattaacg aaggtctcct ttcacatctg
    11881 tttgcactgt atcaggtgca gaaatagcca tttttctctc gatgaaacga ccgaggcttt
    11941 caattccgat attgactacc caataaacaa gggcaacgga gatgaagcgt tcaaaatagc
    12001 gataatcagc tccacctaga atctgagctt gggcaaagac ttccacaaca cccgcactaa
    12061 aagctagaga tgttcccttg gtcaaaccga tgagggaatt aatcaaggtt ggagtagcta
    12121 ccaccgctgc attaggaata atcactcgtc gataaacttg cgctcgggtc atacccagac
    12181 tgcgtgccgc ctcaatctca ccaggattaa ctgagagaat ggctgcacga atggtttcac
    12241 tagcataagc tgcctcatta aaggcaaaag cgacaatcgc aaaagctgca gctggaatcg
    12301 cattgatatt gagaccagtt ccccattgct gattgagggc tttcaaagcc aaagggattc
    12361 cgtagtaggt caacatgagt tgcaccaaaa tcggtgtccc ttttaagaaa ctaacaaaga
    12421 aggcctgcaa gggatataaa atcttgacac gattgatctt cacaatggca aaaagaagcg
    12481 ccaaaaccaa gccaaaaagg gcaccaccaa ttgtcaacat aattgttgtt ggaagttgtt
    12541 ggacaattct agggattcca tcaaagaccg aacgtaggct aaacagcttg ccatccggaa
    12601 tcaattgcat caagttttgg taccaatctg atgctaaaat cgttgtaaca ttcataaaaa
    12661 catcctcttc tgataatgat tcattctacc atgcttctgc cgtcaatgaa attatttgct
    12721 acggtcagat acagactttg tctacctact agtttatcat actttgaaac agggaagtta
    12781 tatattttat ctatcaaaga gatagataaa aactatttca gtcccagttc ttcataagat
    12841 tttcgataac cgatttgctt aacagttcca ttttctacta aaatgggccg ttttaacaac
    12901 ataccgtcac ttgctagcaa ctcagccgct tcttggtttg acaaacttcc taccttatct
    12961 tttagcccta attcacggta tttgatacca ctggtgttga aaaattgctt caattcaaat
    13021 cctgaggttt ctagccaatt caaaatgact tcttggctag gtgtttcttc cacgatatgg
    13081 acggctttat agtccacacc taattgattt aattcttgtt ttgctttttt acaagttgaa
    13141 catttggggt attcgataaa ttctaacatg tgcttctcct tctatttgtt tatatcttta
    13201 aaatctacgc cttcatgctc caagagccaa gctttctttt ccactcctgc agcatagcct
    13261 gtcagacgct tgcctgctcc caacacacga tgacaaggta ctaggataga ccaaggattg
    13321 cgtcccactg ctccaccaat tgcttgagca gaagccactt gcaggtcttg agcaatttgt
    13381 ccataggtca ctgtctgacc ataaggaatg ccctgtaaat agtcccaaac tctcttttca
    13441 aaattcgttc cgattggcgc caagagcaag ttggataaat cctgaggctt gcctttaaag
    13501 taatcatcta agcaagcaat aactgggtct aaaataggat gactaacaac ttcttctatc
    13561 gtttcatctc ctagtcccct ctcaaaatgc ttctgctcct gaacccaaat tccatacaaa
    13621 taatggtcat cagctacaag tgatagaata ccaattggtg aggagtagag tatttttaca
    13681 tacttctttt gcattatttc tttaattttt gataggccaa gcgttcgcca tctactggca
    13741 ccttaccaac ttgtttaaaa ccaagttttt caaaaatatg ttgcataacc ttgttttcag
    13801 catgcgtatc tgagcgaaaa tcaagataat caaaaccttc aatcaagccc tctaagaagg
    13861 tttgagcaac tccttttccc tgcacatctg ctgccacagc aatacggtga aagactagat
    13921 actctgactc tccagcttgc cagtttccct cataaatagc ttcataggcc tcctctggac
    13981 tcttggtcac agcagcatag gctagcagtt ctccctcttc caaggctacg taggcttgcc
    14041 ctgagatgat atcatcgata ataacatctg catttggata gccattttgc cactggtcac
    14101 taccagcatc tgctaaacat tttttggcat cctccatcac ctgcatgatg gcatctactt
    14161 catttggaaa agctaaacga atttccatct tttttcctca tttctgacta gtttctccca
    14221 tcatagcata atttaagtat ttctacaagc agttaaaact tgactttgtg tttttgttat
    14281 tttataatct agttatcaaa actatataaa aaggagttga aaatgaaaac taccttttcc
    14341 tacccaaaat gggcagaaat tccaaacatt gacctctatc tggaccaggt tttgctctat
    14401 gtcaatcagg tctgcgcccc tatctctcct aataaagaca agggcctaac agcatctatg
    14461 gtcaacaatt atgtgaaaaa tggttacctg acaaagcctg acaaaaaaaa ataccaacgc
    14521 caacagattg cccgtttgat tgctatcaca accctcaagt ctgtattttc tattcaagaa
    14581 atagcccaga cacttaacac tctacaaact caagcaagtt cagaccaact ctacgatgct
    14641 tttgtggact atatgaacca aggaattgac ccagctaacc ctattatcca aaccagctgc
    14701 caaaccgtta aactctatca tcaaactcta gacttaatcg atcatactca agaggaggta
    14761 atccaatgaa cactagtctt aaactcagca aacaactcag ttttggagag gagattgcta
    14821 atagcgtgac ccatgctgtg ggtgcagtca tcatgcttat cttgctgcct atttcatcca
    14881 tctatagtta tgaagcacac ggatttttat cctctatcgg cgtttccatt ttcgtcatca
    14941 gtctctttct catgttccta tcatccacca tttatcactc tatggcctat ggttcgaccc
    15001 acaaatatgt tttgcgaatc attgaccatt ctatgattta cgttgccatt gccggctcat
    15061 acacgcccgt tgtcttgacc ttgatgaata actggtttgg ctatctgatt attgtcatcc
    15121 aatggggaac gaccatcttt ggtattctct ataaaatctt tgctaaaaag gtcaatgaga
    15181 aatttagcct tgctctttac ctgattatgg gctggttggt tctggttatc attcctgcca
    15241 ttatcagtca aacgacaccc gttttctgga gtctcatggt aactggcgga ctctgttata
    15301 cagttggagc tggattttat gccaagaaaa aaccttattt ccacatgatt tggcatctct
    15361 ttatcctagc tgcgtccgca cttcaataca tcgctattgt ttattacatg taaaaaagtt
    15421 gagaaattca atctcaactt ttttctttac acatattgat aaagtactgg tgcaagcgca
    15481 catcatcagt caattctgga tgaaaagaac ttaccaacat atttttttct tgggctgcaa
    15541 caatttgatt gttcactgtt gctaaaattt ctacaccctc accaacacta ctgataatcg
    15601 gaccacggat aaaggtcatt ggaatcttgc caactccctt acattctgct tccgtgtaga
    15661 aacttcctaa ttggcgccca taagcattac gctcgaccac catatccata gttcctagat
    15721 gactctcttt ctgagaagtg atttccttag ccagcaaaat taagcccgca caggtcccaa
    15781 acactggtaa gccagataga atggcttctc ggatgggaag tagcatgttc tggtcacgta
    15841 agagcttgcc catggttgta gactcaccac caggcaaaat caaacccgac aagtcactct
    15901 gatcttgctg aaaatcatct agatttctga gttctacact ctcgacacct aattgatcta
    15961 gcacttttgc atgttctgca aaggcccctt gcaaggccaa tattccgatt ttcatctatt
    16021 ttcctcgttc agccatgaga atttggattt cattttcatt aataccaacc atggcttctc
    16081 ctaaatcttc agagatttga gctaggattt gaggattacg gaagttagtc acagccttaa
    16141 caatggcact cgctcgttta acaggatctc ctgacttgaa aatacctgaa ccgacaaaga
    16201 ccccctctgc ccctaattgc atcattaacg cagcatctgc tggcgttgca acacctccag
    16261 cagcgaaatt tacaactggc aattttccat gttcatgaac atattggacc aattctacag
    16321 ggacttgcaa atccttggca gcaacataaa gctcgtcctc acgtaagttt tgaatgcggc
    16381 gaatttcctg attcatcata cgcatatgac gaacagcttg gacgatatcc cctgtccctg
    16441 gttctccttt ggtacgaatc atggaagcac cttcagcgat acgacgcaag gcttcaccca
    16501 aatccttagc accacagaca aaaggaactt ggaattcttt cttgtccaca tggaaacggt
    16561 catcagctgg agatagaact tcactctcgt cgatataatc aatttcaata gcctctaaaa
    16621 tctgagcttc aacaaaatgc ccgattctga ccttagccat tactggaata ctaaccgctt
    16681 cttggatttc cttaatcatc tttgggtcgc tcatgcggga aactcctcca gctgcacgaa
    16741 tatcagccgg aattcgttcc aaggccatca cagctgccgc accagcagct tctgcgatac
    16801 gagcctgttc aggattctgc acatccataa taacaccacc cttgagcatc tgtgccaagt
    16861 ttttatttag ttcataacga ttttcagtca tttgttttat cctcatcatt tgtattggta
    16921 gctacctttt cattttaagt cagaacagaa tgaagcacaa gataaaaaaa ctataattgt
    16981 atggggacag attggctaaa aattatctga ccttaactta aggccagata gctcattcat
    17041 ttctattttt cagccgtaag ggcagccatt gtgatgtagt tgtatggttt gttgaagtgt
    17101 ggcaagaaga agaggtctgt caatgccaat ttatcaattg tcacatgctc ttggatagca
    17161 agtgagaaca tgtggattcc catgctaatt gcaatatcat gtgaaaccat ttgggcacca
    17221 agaatttcac ggctatcttt gtcaaagaca atcttaattg ctacttcatg gttgtcatgt
    17281 ttcatgaatt ctggtttttg aagatcgtta aagcctgttt cagttgcgtt gtaaccagca
    17341 gctttcgctt tttcaagagt caaaccagtt gaaaccatgt gaagaccgta gattgagata
    17401 ccatttgaac cttgaacacc gattccttcc aattcatgtc cacaagcatt gtaggcacca
    17461 acgataccag tgcgaacagc atttgaagca agagcgatat agcttgtatc tttacgagca
    17521 ttgtcataaa cagtcgcaca gtcaccaaca gcgtaaacgc ctgggataga tgtttcttgt
    17581 ttcttgtcta caaggaaggc accgttgcgg aagagttcga tcttaccatc tgcaagggct
    17641 gtgtttggac ggaaaccaac tgcaaggata accatatcca cgtcaaagct ttctttgtca
    17701 gtaatcaagc gttcaacttt accgtcacct tcgattgctt taacagtttg acctagagcc
    17761 aagcggatgt tgtgatcttc caagttcttc gccatcattt gtgtgaagtc tttgtcatag
    17821 taaccgttca agacagtatc aacgatatca acaaggacaa cttcttttcc aagacgttca
    17881 aaggcttcag caagttcaac accgatgtaa ccaccaccaa caacggcgat acggtcgagg
    17941 tgttggctct tgtcagaaag tttattgata acttcttcag cattttggta caatttcacg
    18001 aattgtacgt tttcaagagt tgctttaaat tcgcggtttc ctttaacaat ttcaacacct
    18061 tcgattggtg gcaagattgg tgtagaacct gtagcgaaaa tcaatttttc gtatgattct
    18121 ttgtgctctt ttccttcaac ttccgctgta actactttgt tatcatagtc gattgaaaga
    18181 acaggtgagt tcatgtaaac tttagcacct ttagcttcca atttttcttt atcagaatag
    18241 aacaagcctt cagcaccgtc aatttgttca ccaatccaaa gagccattcc acatcctagg
    18301 aaagagatgt tagagttttg gtcaaataca acaatttcgt tctcatttcc aaaattatcc
    18361 aacatggtat tgatacatgc tgtaccagcg tggttagcac cgactacaac gattttactc
    18421 ataaaaattt cctgccttca ttctaaattt accttactag tataccattt accgttagcg
    18481 tttacaaggg gggtactatt atttcagcat tttttatcaa aaataattcc ccatttatcc
    18541 tgttttcaag cctgatgaat tttatgagca tatttcttga ctttttccaa attttgtttg
    18601 tgaaaattct aactttatgg tattataata acatgaaaat gaaatgtaag ggcttcaatt
    18661 tagatgatta tttgatatta caacttattt tctataagag aaaggagttg gtagcttgac
    18721 tcttcgttca cattctgaac ggctaatggg gactactatc actatttcat tagtggatga
    18781 gcaagccgat atctttctcc aaaaatcctt tgacttgctc aaagaacttg aataccgctt
    18841 caacgccaat agtcaagaat ctgagttgat ggaaatcaat tatcaagcag gaatagcccc
    18901 cgtcacggtt catccagacc tgtttgagct gatttcactt gggttagagc atagcctagc
    18961 gctctctagc cacctcaata tcagcattgg tcccttaatt caaacctggc gtatcggttt
    19021 ttcagatgcc aaggtcgcgc agcctcaaga aattgaatcg gtgctgcctc taatcaatcc
    19081 tcatggtatc gagttagatt cttctacttc tactgtgttt ttaaaacaga aaggaatgaa
    19141 gatcgatcta ggttgtttag ccaaaggata cagtgcggat aaggttgccc aatttcttag
    19201 gaaagagggg gtgacttctg ccttgatcaa tctgggaggg aatatcctga ccattggaaa
    19261 aaatcaggca agaggggata acccatggca aatcgggatt caagacccag ccaatcctag
    19321 gggaaatcat ttaatgacca tccctgttgt caataaatct gtcgtgactt caggcattta
    19381 tgaacgtcac ctgaccgtcg atggacaaga ttaccatcac atttttgaca gtcaaacagg
    19441 atatcctgtt gaaacggaac tagcgagtct aacaatcatc tctgataaat cagtcgatgg
    19501 cgaaatctgg acgactcgac tctttggaga aagacctgct tctatcctct ggcaagtcga
    19561 aagtttggag ggcatcgaag tcatcctcat cgataaagaa ggccacctaa gctgttcttc
    19621 aggaattcct actctataga gacaactgtt tcaatggaat tttaaaattg tattatgtaa
    19681 aaagagaaag gaaatctcat gttaaaactt attgctattg ttggaacaaa ttcaaaacgt
    19741 tctacaaacc gtcaattgct tcaatacatg caaaaacact ttgctgacaa agctgaaatt
    19801 gaacttgttg aaatcaagac cattcctgtc ttcaacaaac cagctgacaa gcaagtacct
    19861 gctgaaatat tggaaattgc tgctaaaatc gaagaggcag atggcgttat tatcggtact
    19921 cctgagtatg atcactctat tccagctgtt ttgatgagcg ctcttgcttg gttgtcttat
    19981 ggtatttacc cacttttgaa caaaccaatc atgattacag gtgcttctta cggtacgctt
    20041 ggttcatctc gtgcccaatt gcaacttcgt caaatcttga atgctcctga aatcaaggca
    20101 aatgttcttc cagatgaatt cttgctctca cactctcttc aagcatttaa cccaagtggc
    20161 gacttggttg accttgatgt tatcaagaaa ttggatgcca tctttgatga cttccgtatc
    20221 ttcgtgaaga ttactgagaa attgcgcaat gcgcaagaat tgcttcgcaa agatgctgaa
    20281 gactttgact gggaaaattt gtaagatagg agaccgaaag aatgaaattt gttggacttg
    20341 ttggatcaaa ctacgatcaa tcatataacc gcaaactctt ggaatttatc cgtcgcaatt
    20401 tcaaattcaa atttgaatta gaagtacttg aaatcgacga agttccaatg tttaaccaag
    20461 atgaaaaatg ggacgaaagc ttccaattgc gtttcttgta taacaagatt acacgtgctg
    20521 atggtgtcat tatcgccact cctgagcaca accacactat ctcagcttca ctcaaatctg
    20581 tacttgaatg gctttcatac gaagttcatc catttgaaaa caagcctgtt atgattgtgg
    20641 gtgcatcata ctatgaccaa ggaacatcac gtgctcaagt tcaccttcgt aaaatccttg
    20701 atgctccagg tgttaatgcc tacacgcttc caggtaacga attccttctt ggtaaagcta
    20761 aggaagcttt tgataacaac ggaaatatca ccaacgaagg cactgttaaa ttccttgaaa
    20821 cttgcttaga taactttgtt aaatacgtag gagtcgtttc gaaattgaaa aaaccaaaac
    20881 caatcgaatc agaagacttg gattgtggaa aaccaatcgc tacaaccatc acagaagttg
    20941 accctgacga tccagaatgg gtagaaaaag ttgcagcaat cactggtgct gtttctggtg
    21001 atacctatgt caaattggac cacggtatcc taacagttaa ccaaattgat atgttcttga
    21061 aagctatgcc atttgaattg acatacgctg acgacaacaa ccaattcctc tactacaaca
    21121 acgctcacca agatccagac actatgttcg ctaaacgtgt accacctcaa tcaggtagcc
    21181 gtatgtcgac tgttcatggt tctcttccac cagcacgtat gaagaacgta gagtgggtta
    21241 tcggaacact tcgcaacgga aaccaagaat acgtccgtac gatcgttcca ggttctcctg
    21301 caggtgttat caacactcac aactaccaag caatgtacta tcctgatgga tcatacgctg
    21361 gtatcaatga aatcgtcttt aacttccaac catggcttga ctggtaccta aaagagactg
    21421 gtcaacgttt ggtgggtggt agcggaccat ttgctcctgc tgccggaggt catggagacg
    21481 ccgatgctac ttctggcgct tctgattcag gggatgctgg aggccacggt ggtgacgcag
    21541 acgctacagc cggtgcaagt tactaatgat agtttttagg aaccattatg gttccttttt
    21601 tagcgaaaaa agactagcaa acacaaactg ctagtctctt tgttatcgtt tcatctatcc
    21661 ttgttaaaag aaagaatact tatactcaat gaaaatcaaa gagcaaacta ggaagctagc
    21721 cgcaggctgt acttaagtac ggcaaggtga agctgacgtg gtttgaattt gattttcgaa
    21781 gagtattatt atgaatttgg gtcatcaaga ctacggccat gtaatccttt ttcacgttgt
    21841 acttggcgta gtttttctgg tgtaacatcg tttccttctt cgtccacaat tttgattcct
    21901 tcaatgtggt gacgaacagc gcggcgataa ccttcgatgt actcctcacg tagtttggct
    21961 tgttccactt tttcttctga tgttaagcct tctgtttttt tctttttagc aagctcattg
    22021 atacgagcaa tttttttcgg atccatttct tctcctttgt aataagataa agtccgttta
    22081 tcaaatttta tttagtgtta atttggttaa aacaagcaaa cttagctgct ttcttggtta
    22141 gttgtgacaa gattgccaaa cgattttgac ggacagcctg atcttcagcc attaccatag
    22201 tattttcaaa gaaagcatca atgactgggc taagcgcaaa gagttgtttc aattgctgac
    22261 ttgcaggtcc tgataaaacg agtgtttcta ctgcttctgc caaagctttt tcttggtcat
    22321 tctcaaatag tgctgaatca actgtagcaa ccccttctgc cttctcagcc aggttaaagg
    22381 cacgagaaag tgattcaaca gatggtttaa aatcttcttc cttgcttact tctacgagag
    22441 cacttgctgc ttccaacata tctgccacaa caaagtttga acctgcaaga actgcttcct
    22501 tgatatcttt tggagtagag cccatcatct tatcaacacg agccttgata aagttcataa
    22561 cctctgcttt attttcataa gtcaaactgt caaatttcaa tgcataaagg ctatcaatca
    22621 gctcatccat agcaatgtgc caaccaaagg catccaagat acgaaccaca ccttgagttg
    22681 cacgacgaag ggcataaggg tcattagaac ctgatggaat caatcctact gagaagaaac
    22741 tcaaaatcgt atccaatttg tctgcaatgg ctagaactgc accgaccttg ctctctggaa
    22801 gttctccttc agctgatgta ggcatgtagt gttcacgaat agcagctgcc accgctggag
    22861 tttcaccagc aagaagggtg tatttttcac ccataattcc ttggagttcg tcaaattcac
    22921 caaccatacc tgtcaacaag tcaaacttgt aaatggctgc tgcacgagca aggtcaactg
    22981 tttcatccac tgacaaacca gctttttctg ccaaaagtac agtgatttga cccgtacgaa
    23041 tcatgtgttc acgaagggaa ccaatcttct catggaaggt gacattgttt aatttttcaa
    23101 caagatctga aatcaccaat ttttggtctt cacgccagaa gaattctccg tcttccaagc
    23161 gggctaccaa gactttttca tttcctttaa tgacattttt caaacgctct gcgtttccgt
    23221 tacgaacaga aatgaagttt ggcaaaagtt ttccatcttg atcacgaaca acaaagtaac
    23281 gctggtgttc cttcatagaa gtcaccaaga cttcttctgg aatttcaagg tatttagcat
    23341 caaaacttcc catgaaggca gttgggtatt caaccaaatt caagacttca ttcagcaaat
    23401 ccgcatcaat ttcgatacgt acaccatgtt ttgcctcaat ttccttgatt tggtcaacaa
    23461 tcatttgctc acgttcacat ggatctgcga ttacaaactg cttacgaagg tcttcttcat
    23521 agctcaatgc tgactgaatt ttggtttctt tccccaagaa acgatgacca cgactcacac
    23581 gacctccctt gatatcaagg aaatccaaat caaactcttc ttcatctaaa agaacagtta
    23641 aagtgtggac aggacgaatg tattcaaagc tatttcccgc ccagtgcatg ctgacaggga
    23701 aagtcagtga cttcaagaca tccacaatgc ctggaacaat ggcttcaact gcttgaccaa
    23761 tttcttcctt agtgacatag acatattctt cacccttgat ttcacggaat tcgatatctt
    23821 caacagtcaa gccttttcca cggacaaatc cttgagctgc tttggtgaag tttccatcac
    23881 tatccaaggc aattttcttt gctggtccct tgaaatcttc tgtcaaatca gactgtttgt
    23941 ctgataaacc agtcacacga acagccaaac gacgtggtgt tgagaaggtt tgaatggctt
    24001 caaaagacag gcgttttccc ttgaggaagg ctgccatttt ttcgcctagt tgtttttcac
    24061 ttggtgtgac aacataggct ggtaattctt caagaccgag ttctactaat aagttttttg
    24121 tcatgttttt tctccgaaaa gtatcttttt attttccagt ttgccttatg tgattggcac
    24181 gcaagcaacc aacttcgttg tttcattgct aaaattggag ccaaaagtct ccaattttgc
    24241 ctagtatcct tagtttcact aaggatacct tcatcactgc ggcaactggc tcagggctca
    24301 ctctgttcgc ccattttcgt aatttgtcac tctctttatt ctgcgtcttc tgctaggagt
    24361 ttagctcttg tttcttcatc caaaagtggg tagcctaggc gtttgcgttc tgcaacaaag
    24421 gttttggcta caacacgggc caagttacgg atacgagcga tatagcctgc acgctctgtt
    24481 acagatacgg caccacgcgc gtcaagcaga ttaaaggtat gtgaacattt gagaacatag
    24541 tcataggcag ggtgtaccaa gccttcttct aatgcacgac cagcttcttt ttcaaactta
    24601 tcaaagtttt caagcaacat ttcttggtcc gaaatttcaa atgaatattt tgagtgctca
    24661 tactcaggct ggataaagat ttctccgtat tttacaccat cagcccactc gatatcatag
    24721 acagagtcta cttcttgaat gtaagaagcc aagcgctcca aaccataggt aacttccgca
    24781 gtcacagggc cagttgccaa tccaccgact tgttggaaat aagtgaactg agtgatttcc
    24841 attccgtcaa gccaaacttc ccaaccaaga ccagctgaac cagttgatgg gttttcccag
    24901 ttgtcctcaa caaaacgaat atcgtgctcc aaaggattga ttcccaattt ttccaaagac
    24961 tcaaggtaaa gttcttggat atttgatgga gaaggcttca tgaccacctg gaattggtgg
    25021 tgttggtaga gacggttagg gttttcccca taacgaccgt cagcaggacg acgtgatggc
    25081 tctacataag ctgcattcca tggctcaggt ccgatagcac gaaggaaagt gtaaggactc
    25141 attgtccccg cacctttttc attgtcataa gcctgcataa gcatacaacc ttggtcattc
    25201 caaaattgtt gcaaagtcaa aataatttct tgaaatgtta atttcttaga cattgaatac
    25261 tccttaataa aaaatgattt cttgcgacac gagtctgcct cgtcgattat acgaggcaag
    25321 acgagttagt actgcgtcta gctcagcacc ctagtgctga gcgtggggca gtccgactgt
    25381 aaggaggttt ctgccactga cgcagtgaaa tgtcaatttc ttagacattg tttactcctt
    25441 tagtttttat atttcttttt caattaattt ctgctgaaca aaccaatcta acaagggaaa
    25501 agttttttct gtatttgccc atagatgata agaatctaag accgcttgta cactacctaa
    25561 attttctacc aacttatcta ctgtcaaaaa gctgcgccag tattcataaa aaatacttgc
    25621 atagttctta tcataagtcg aagaaccaaa atcattcaat gaatgccaac tatacttctt
    25681 ctgaaaaagt tctacgagag attgattaca aattttttcc gcttgaaatt cctcttctgt
    25741 caagaaatac ttgcgactaa tatattcaac catcccctct tcgaaccaga tataagagtc
    25801 ataaccatca aaatcatcta aaaaatgctc cgaccaatga gctaactcat gtcctacaat
    25861 ctgtaagagg aaattttcag ataaagaatg atagtgactt tctattgctt gagtttgctg
    25921 agaacactcg tagtccatca attgatacaa atacaactct ttccaaacag ctaaatcagg
    25981 cgccataacc attcgtctat tatttgtata ggctggaaca gcgctttccc taataatctg
    26041 tgtagcagca ttaaaatctg accaaataac ggcttgcggt aaatcacaga ctgcaagttc
    26101 attctttaaa aaagattgat aatctttcaa cttttcagta tttcttacta caaaatcacg
    26161 aaatgtagct agttgactat cgtcttttac aagataaagg ttgtccacgg ctctcctttc
    26221 tttcacacaa tagactgaat aagcaaaaga accgcgtccg acaatcctag gttgatttaa
    26281 cctaggggcg tcagaaacgc ggttccaccc taatttatta cttcattgtt tttgaaaata
    26341 ctacagaaag cgccagctca ttattttgcc ctacttggct cccactatcc caagctcgct
    26401 tgaagaacgc cataagactt tctttcctgc tgactattat atcaaaaatt agaataatgt
    26461 acaattcttt ttatgatttt ctagaaatcc acatcatcaa ctcgtggagc acccgattga
    26521 acagcaatcg tttttaaggt ttctctctcc tcatgactca gttcaattcc aaagcaatca
    26581 agattagctt gaatacgaga ggttgtgaca gattttggaa gtggtaaaaa tccttctgcc
    26641 aagctccagg ccaaggctat ctgagcaatc gattttccgt gatttgctgc gatttcttgc
    26701 acttgcttgc tatcaaatag ttctccctga ccaaaaggcc cccaagcttc caataaaatt
    26761 cccttttcac gacagtaagc tacgacttga tcttgataca cacctggcgc caagcgaact
    26821 tgattgaccg caggaacgat agttgcagtt tcaagcaagg catccaaatg atggggaaga
    26881 aaattgctaa cgccgatagc acggattttc ccttcttgat agaggtcttc catcgctctc
    26941 caaacttccg cattgcgagt tttccatgcg tcattttctc tgagcggttt tgggttcggc
    27001 caatgaatca aatacaaatc caaataatcc aagcccagtt tttctataga tttttccaaa
    27061 gcttgacgag tttgctcata ggtttgctga ctattccaaa gcttggtagt tacgaacatt
    27121 tcttcacgtg gaactccgct atctttgatt gcttgaccaa cactttcttc attctgataa
    27181 atcgccgccg tatcaatatg acgataacca gccttcaagg cttctaacac tgcacgatag
    27241 gcttcttctc catccttagc cttaaaagtt ccaaatccca atactggaat ttctactcca
    27301 ttatttaatt gataggtatt catatgcttc tccttctatt ttattcatca attatagcat
    27361 aaaacatttt ttaagtagta ctatcttctg taaaaaataa gtctgtcaaa tatctaacag
    27421 acctattttt tcttgcttat tcatcacgac tatagtacag ctcatgagct tttaggcgag
    27481 tattgagcat ctctggtatg gtcacaaagg tataaccttg atttttcaaa tactcaatga
    27541 cccttggcaa ggcattgact gtcggactgt gaatatcatg catcaaaacg atagagccgt
    27601 tagctacttg atgctgaatt tctgtcaaaa tagatgcttc atttttactc ttccagtcca
    27661 gactatccac atcccacatg ataaagctca aatccaagct attgcgaata tcatctgtaa
    27721 tagcaccata aggtggacgc atgagtttag aactagaacc cagcacttta gttagcacat
    27781 cctcagtatc agtaatctgc tttttagctt catcaagaga gagttgcgag agaatcggat
    27841 ggctccaact atggtttcca acaacatgac cttcagattt tatcctcttc accaagtcct
    27901 cattcccaga aacatttttc ccaagcacaa agaaagtcgc tttaatatca tatttagcta
    27961 gggtctctaa tacctgcggg gtcgttgctg gatttggacc atcatcaaag gttagagcga
    28021 caactttttg atatttctta tcaaagtaag attggtacaa ggccgcatct ttttcgagta
    28081 agtacgaaga ttggataaca tcaaagaaag cagatactgg caaggctatc tcttctaaat
    28141 tttcaaccac aggacttgga taaaggataa tctgactatc cttgtaatca aaattccatg
    28201 cagacaagtc ttggtcagag aagtttttta caatctgctc actctggtct tgctctattt
    28261 ttttatcctc tatgaaggag gtcaactctt ttatcagctg ttccttagcc ttactaacat
    28321 ctgaaaacag ttggtcaagt gtaaaaggtt gcccatcttc tgttaagtga acctttccta
    28381 gactggtctt ttcagtctct tcaaccttaa aagcaactaa atcatagatt tgtttggtca
    28441 cattacgatt aacgactccc tttaaacctg actcttcttg ctctgtatag tagaaaacaa
    28501 gattgtcctt actttctagc ttgtccttaa catcttgatt tatcaactcc ctaacagagg
    28561 aaatcacttt ctccccttgg agaggataat aggcaatcac ttcggcttgc ccctgacgaa
    28621 aatgctcctt ctgatttccc tcactcaatt gatcatcttt ctcttttttg agcgattcaa
    28681 tcttttgctc aaaacttttt tgctggtaga tcttaaaagc aataaatccg cctaataggc
    28741 aaatagaaat tgctaaaata ccaatcaaag ccaataatac atgtctcgtt ttcccgtgtc
    28801 tgccacgtcc tagtctactt ttattcatat ttatatcata acaaatttga gcaataattt
    28861 caatgataca atttggcaat ccacaattcc tctagcaagc caaagcatct tacatcaact
    28921 ccaacatccg tatctgtaga gattatgtag ttttctatct atggaatttc tagtagattg
    28981 aagctagaat agtagaccta tacttctaaa acattgttag aaatcgattt gattgtcctg
    29041 atcgatttgt cctgttctta tttcatttta ctataaaact atgagaagct aggtcatctg
    29101 agaagtaatt actatcgaca attgcgatag cgtatactgg tgcaatttgt ttgtagctct
    29161 ggtgggtatc accttcacgt tggcgaattt tttctaggtt ttgattaacc tgactgcaca
    29221 gataagccca taggcgattg atgaaaaaat tctgatgatg aacctgaatt tcgatgataa
    29281 cttgggttcc attatctaac tccgccaaga catctatact agtatagaaa tcctgcgctg
    29341 agtagggcat ggaaggcaag acgtgaatgt tacttccctc caaaatcgtc acattttttg
    29401 ctggcaagtc cagcatatcg cggataaatt gacaaagcat tagttgggct gatacccgga
    29461 tgtctgagaa tcctcctttt cctccttttt ctccttttcc tccttctatt atagcacatt
    29521 tttaaatcta ggtttgctag attctatgct tctatctatt tattcggaaa agaaagcttt
    29581 tcttcagaag aaagctaata gcttatttga agttttctcc tctctgttgg atagtcccgt
    29641 ctatctatgt tataatgaaa gaaggattta aaatcggaaa aggagtattt atgctaaaat
    29701 taggtgtcat cggaactggc gctatcagcc atcatttcat agaagcagcc cataccagtg
    29761 gagaatacca actggtcgca atctattcta gaaaactaga aactgcagca acctttgctt
    29821 ctcgctatca gaatatccaa ctattcgatc aattagaagt cttcttcaaa tcttcttttg
    29881 atttagtcta tatcgccagt ccaaactcct tacattttgc tcaggcaaaa gctgccttgt
    29941 ctgctggtaa acatgttatt cttgaaaagc cagctgtcac tcaaccacaa gaatggtttg
    30001 atttgattca aacagctgaa aaaaataact gttttatctt tgaagcagct cgtaattacc
    30061 acgagaaagc ctttactact atcaaaaact ttttagcaga taagcaagtg ttaggagcag
    30121 atttcaacta tgccaaatac tcttccaaga tgcctgactt gttgactgga caaacaccaa
    30181 atgtcttttc agaccgtttt gctggtggag ccctcatgga tttggggatt tatcccctct
    30241 atgctgctgt tcgtcttttt gaaaaagcta atgacgctac ttaccatgct caacagcttg
    30301 acaatagcat tgacctaaat ggagatggta tcctcttcta cccagactat caagttcaca
    30361 tcaaggctgg aaaaaacatc acttccaatc ttccttgcga gatttataca acagatggaa
    30421 ccttgactct caacacgatt gagcatattc gctcagctat ttttgccgac caccaaggaa
    30481 atcaagtcca gcttcctatc caacaggctc ctcatacgat gactgaggaa gtcgctgcat
    30541 ttgcacacat gatccagcaa ccagatctga atctctacca aacttggctg tatgatgcag
    30601 gctctgttca tgagctacta tataccatgc gccagactgc tggcattaga tttgaggcag
    30661 aaaaatgaaa accaaactac cgactgaatg gcaagaactg agtgaccaac tcggtttcca
    30721 agaattcacc cccattcaaa ctcaactatt tgagctcctt cttgctggag aaaacctcct
    30781 aggagtgagc caaaccggaa ctggtaagac cctagcgtat ctcctaccaa gtcttctcag
    30841 actacaaaag aaaaaagccc aacaactctt gattctagca ccaaacacgg aacttgctgg
    30901 acagattttt gatgtatgta aaacgtgggc agaagctatc ggattgactg ctcaactctt
    30961 cctttcaggt tcaagtcaga aacgacaaat tgaacgtctt aaaaaggggc cagaaattct
    31021 gattggaact cctggccgta tctttgaact cattaaactt aaaaaaatca agatgatgaa
    31081 tgtggaaacc atcatcctgg atgaatttga ccaattacta gatgattctc agattcactt
    31141 tgtagagaaa atcactcact acgcacctcg tgaccaccaa ctggtctaca tgagtgccac
    31201 gaccaagttt gaccaagaaa agattgtgcc gaatacacgc actattgatc tctctgatca
    31261 aaaattggac aatatccagc atttctacat gcaggtagac caacgtcatc gagtggatat
    31321 gctacgaaaa ctggctcatg tagaggattt ccgtggtcta gtcttcttca atagcctgtc
    31381 agaccttggg aatgccgagg aaaaactaca gtatcgtgat atattggctg tttccctcgc
    31441 tagtgatgtt aatgttaaat ttagaaaaat catcttagaa aagtttaaag ataaccaact
    31501 aaccctgctt cttgcaactg accttttggc tcgtgggatt gatatcgata gcctagaatg
    31561 tgtcgtaaac tttgatattc ctagagatag cgaaacctac acacaccgtg ctggccgtac
    31621 tggtcgtatg ggcaaggaag gttatgttat cactctcgtc actcatccag aagaaatcaa
    31681 aaaacttaaa aagtttgcaa gtatccgaga aattgtccta aaaaaccaag aactctatat
    31741 caaataaagc cccattgctc tatacacatc cagtgtatgg agctttttta caagcaattc
    31801 aattttatac tcatctgttt tcaaaaagca ttctagtcca tctccgatta acgatgggct
    31861 ttatcacctc cttctccagt ccttgtatga tatcttgaag ttgattcatg acatcttcca
    31921 aagtttgaaa ggctttattc ttaaatccac gtttacgaat ctctttcaac acttgttcaa
    31981 tggggttcat ctctggtgtg tatggaggaa taaaggtaaa accaatatta gtcggaatct
    32041 ttaaggtact tgatttatgc catatagcat tgtccataac gagtaaaagg ataagcttgt
    32101 gaaagctctt ctaaaaaggc gttcatccac tcagtattac atctaccagc tattaagaaa
    32161 aatgattcgc ctgtatgggc atcaacagct ccataacaat agcgaaattc tcgtatatag
    32221 tgactatgga catgtggacc tactcctatt ggagaccaac aagatcccag tttactgatt
    32281 ctaccgaaac cagcctcatc ttggtacatc aagcgaacct tacgaaaacg tctactatat
    32341 ttaaatcgct ttcttgcctt cttgaattga gattttattt ttagacgcga caatggtttg
    32401 agcgtctgtt ttcctaggat gttctggacg tggcataata tttcgccagc catggcgctt
    32461 caacagttga tagaaggcat cacgtgtgta ggaacgacct aactcctttt tataagcctg
    32521 aaataaggca tcaattgtaa caaattctcc tgcctctgta gccttcaaat gacgggcaag
    32581 aaaggctttc tcttcctcaa ctgtcatata tgcatggtta cgaccaccac gtgtttcttg
    32641 aaggagagag tcgagtccga actcctcata ttttttacat tttgctaaat cgttgtttga
    32701 ttacagtcta aaagctctat aatctcttta taagatttgc ccatcagacg aaatagaacg
    32761 atttgaaggc gtttatgata tttagctgta cgagagtctt ttaaaagtgt tttgatggtt
    32821 tggatttctt ctttagttga tttcatatta ctattgtata atgctttttg atttgagtct
    32881 agtattatac tcttcgaaaa tctcttcaaa ccgcgtcagc ttcgccttgt cgtatagatg
    32941 ttactgactt cgtcagttct atctacaacc taaaaacagt gttttgagca gtctgcagct
    33001 aactttctat aacaaaatga aataagaaca agacaaatca atcaagacaa tcaaatcgat
    33061 ttctaacaat gttttagaag tagatgtgta ctattctagt ttcaatatat tatagtttgc
    33121 tctttgattt tcattgagta ttagttcaat atctaaaaaa agaaccttgc caagcaagat
    33181 tcttttagtg tctgacttaa ataattgttc ttctgggaac taaatcgaat taagcttcga
    33241 tttctgtaac catacctgaa ccaacagtac gtccaccctc acggatagag aatgtagtac
    33301 cttgttctac ggcgattggg tgaatcaact caacgtcgat tgtcacgtta tcaccaggca
    33361 ttaccatttc agtacctgct ggaagttcga ttgaacctgt aacgtcagta gtacggaagt
    33421 agaattgtgg acggtagttg ttgaagaatg gagtgtgacg tccaccttct tctttagtaa
    33481 ggatgtagac ttcacctttg aatttagtgt gtgggttgat tgaacctggt ttagcgataa
    33541 cttgtccacg ttcgatttca tcacgttgaa caccacgaag aaggacacct acgttatctc
    33601 cagcaagacc ttcgtcaagt tgtttacgga acatttcaac accagtaaca actgcttttt
    33661 gagtttcttc tttgatacca acgatttcga tttcgtcgtt gactttaacg ataccacggt
    33721 cgatacgtcc tgaagcaact gtaccacgtc cagtgattga gaatacgtcc tcgactggaa
    33781 gaagcaatgg tttgtcagtg tcacgttctg gttctggaat atactcatca actgtgttca
    33841 tcaattccat aacgatgtct tcgtatttag agtcaccttc aagagcttta agtgctgaac
    33901 cttggataac tggaagatcg tcacctggga agtcgtattc tgacaatagg tcacggattt
    33961 ccatttcaac caattcaagc aattcttcgt cgtcaaccaa gtcaactttg ttcatgaaga
    34021 cgataaggtg tttaacacca acctgacgtg aaagaaggat gtgctcacga gtttgtggca
    34081 ttggtccgtc agttgaagct actacaagga tagctccgtc catttgagca gcaccagtga
    34141 tcatgttttt aacgtagtcc gcgtgtcctg gagcgtcgat gtgagcgtag tgacgttttt
    34201 cagtttcgta ctcaacgtgc gcagtgttga tagtgatacc gcgttcgcgt tcttctggag
    34261 cagcatcgat agacgcatag tctttaggtt ggttaactga tgaaggcaag cgacgtgcca
    34321 aaacagttgt gatagctgca gttagggtag ttttaccgtg gtcaacgtgt ccgatagtac
    34381 caatgttaac gtgtggttta ctacgatcgt atttttcttt tgccatttga gtaaaagcct
    34441 ccaataaaat atattttata gatagacagt aggcaataca gtctaacttt ccttactatt
    34501 ttatcaaatt tcagctaaat tgcaagtgtt ttacaacgtt tttgtgaatt attcttggta
    34561 aaaatttaac taactaatag aaagtactaa atagacttat ccttcaagga gttttcagca
    34621 ttatccatcc actcacttgc tgaaaatgta aacagtctct ggtttatata gtaaaatgaa
    34681 acaagaatag ggcaaatcga tcaggacagt caaatcgatt tctaacaatg ttttagaagt
    34741 agatgtgtac tattctagtt tcaatctact atacaacctc aaaactgtgt tttgaacaac
    34801 ctgcggctag cttcttagtt tgccctttga ttttcattga gtataaaatt gcagataaaa
    34861 cgataacaat cataggactc agcagagtca atgtaggtcg aagaatagcc cccctaatcg
    34921 cttattttat agcaaaatga aatagaaact gaacattttg ttgaggaagg taaatcaatt
    34981 cctcacaatg tttgagaaag aagggaggac tattccaact tcaacccact ataaagcaaa
    35041 cttacaagat agggaaccca tctccgataa tattccgata atatatagta gaatgaaaac
    35101 tgcacaattt gattggagaa ttcaaaccaa tttctcacaa tgttttagaa acaagggtct
    35161 attatttcaa ctgcaaccta ctatagccca ttgaagctgg aatagcccac taagacttct
    35221 aaaccactgc tggagaggag tttgtttaga gtttctttca tttccctaaa aaatcaaaaa
    35281 gagagaacca gtctgatcct ctcttactta tagatggtgc tcactcaaat gttaaaggag
    35341 ctatttctta gagataaagg aatttgaata cagctactgc cgcaattgct gctgcgatag
    35401 gtgctactac tggtacccaa gaataccacc attttgaatc gcctttatgc tcaccaagaa
    35461 ctgattttgg aaggaaagca tgaaggagac gtggtcccaa gtcacgggct gggttcaagg
    35521 caggtcctgt aggtcctcca agtgatgtta ccaaagccat aacgaggaat ccaagtgcca
    35581 agtgagccac agaaagtcct gaagcagtgt gtggagccac ctgtgcttta atagccaagt
    35641 cagaaaaatc aactgtttgt cctgcttcta ttgccttttg tttcatgaat tgaagcactt
    35701 cagcaccaaa gaagttttta gtcaaaccaa gagctgcaaa gaacaaaaca aatgaaccaa
    35761 caaactcatt aatcaaacca ttgacagttg ctgcatatcg actttctttt gtaccatggt
    35821 caatacttga aatagttgag aaagttccca agatgttatt tggtttttca gttttcaagt
    35881 agaatggacg gtatgttgcc acaactaagg cttggccaaa gatagccccc aagacttgcg
    35941 cgataatgta aggtaccact tgtgcccaag ggaaaagacc gctaactgca agccctagag
    36001 tgaaagcagg gttgatgtga ttcccagata cgttaccaaa catcaaggct gggatcataa
    36061 cccccatacc ataaccaaca gcgatgacga tccagccact ttggtgacct ttcgtacctt
    36121 taagttcaac gttggcaact gcaccattcc caagaatgat caaaatggca gttcccaaaa
    36181 attcagtggc atacttcagt gcccatgtga aatccatttg ctagattctc cttaaaattt
    36241 tttagatgtt ccttatttta tcaattttta ccctatttag caactgattt ctggaaatat
    36301 ttttaaaaaa ataggattca tagtttccca gttcaacgta attgtaagcg tttttattct
    36361 tcacgaaaga cctcattctc aaaaccagga aaaagcccac atctgtgatc ttttccttgt
    36421 tcctagattc taaaatctat tatttttcat cttctttttt cttgaagaat cctaatccta
    36481 gaccagctaa caaggtcatg ataccagcac tagccaaggt agcattagct tctgtacctg
    36541 tgtttggcaa ttcctctctc ttacctgtct cataagtcgg aacttctggg tctggattca
    36601 ctggagtttc agtttttgga gtacctggtt ctggagttgg tttatctggt gttgataaac
    36661 ggtcatacct taccgttatt tctttatcac tagagtctga cgtaacttct tgtgattcaa
    36721 ctgttggaat atctggatct ttgtacttgt caatcttacc agatataacc tcgtcccagt
    36781 ttcctgttgt ccattcaccg taggttacaa ctcccgtgac cttgttctca gtttttgtac
    36841 ggcttaaggt tacaggttga acaacatctt tttttacatt ttggttcgta actttatcaa
    36901 cgtaatgaat gatacgcgtt atagtcttcg tctcagtaga ggttgctgtt ttgggaacca
    36961 cttttcctca acattctcac ggtagtaata gtcaactgtt gcaccgtctt ctggtacgca
    37021 tttgcaggag ttgctaccaa ggtgtatgtt gttttccttg tgataactcg gtcttctttg
    37081 tcctcagttg ttgttttccc ttcaatagtt tttgattctg tggtatactc agaacctatc
    37141 gctaaatcag cttttataac agactctgcc aacttctctt ggctaccttc tttatagtaa
    37201 ttggctgtta ctgtagcagt ggttggcgct tcgctttctc tataaactaa ggtcactgtt
    37261 ctacctttgc ttacaatatt cccagttaaa cttgcagaat ttgtatctac ttctttaaaa
    37321 gtataatatt ttccgtcagt agtagtcatg ctactgagtt ttttatctgt gacattatag
    37381 ctggtaccaa tcagttgttt tttattggta atgtaggttc cgtcactttc tttttctcca
    37441 attccagtat catttttcaa tgatagcaaa cgcccttgtt catcaacata gcgaactttc
    37501 acattttctg agattagttc tgccaattct gaggtttttt tctttttctt gatttcttcg
    37561 gttattttcc ctttctcttc ttcgggaata tttagttttg gaatgatttt ttcaacaacg
    37621 gttcgtgatg gttccacagt atcttggatg actgaaaagt cagctagaat tgggagatta
    37681 tactgaacac ggtgactttg agtgtttact cctactcttt cattattctc tgaaaatact
    37741 tgtacggtat aagaaacaac atcttttcct aatagaacat ccccagtaga gaaatagccg
    37801 ccttttccta gtttgctatc tccagagccc acttctttcc taatcttatc agatagtttt
    37861 ttaccagtca gtacattcgt tcgcacaatc cctttgtcta cccctacaaa gtgggagaat
    37921 tttttgaact cttcagaacc agatctagcc caaccattat taagggcatt tgcttttgta
    37981 tttgtattct ctctcaaagg tttggcgatt agaattatat tcatcggcgc ttagagttgc
    38041 tgctatatct gactcttgaa taccaacttc cttactacca tttctagcgg cagtatatgt
    38101 gtatttatct gtttctactt ctagctgatt atccttaaca tgataggtaa ttttctcctg
    38161 gtataagagt cttcagtagt ttatatgctc tgtcatcatc tttagcttta gaagcagctg
    38221 agtttagcca agttggggta ttaggagtat ctttatcagc ctgtttcaag acattattca
    38281 agtcatttgc tagcctattg gttatcctca ctgtgaaagt tttcttccag tctgaaccac
    38341 ttttattaga cttagatatg ctcatgaaat cctggtcaac attcaacaca atatcgcctt
    38401 gttttttagc atcttccgtt gcttctgctt caaattgatc atggagtttt tgttgctctg
    38461 gtgtatagtt tttttattta cacgatttaa tgtactattt tttattttag tattaagaac
    38521 tccattaata cgatttttaa attctgcttc aaaaaatccc ttaatttgtt ggtgcgcaag
    38581 ttcaacattc aaacctttct tatacaagtc ttcattctga tacaagtctt cattctgaac
    38641 gatttcggct acacggtgaa tggtttgatt gtataccgtc ttctcttaac cagcagtatc
    38701 cttagtttta atgactactc gataggttcc tttagaaccg ttatagtcat ctagttttaa
    38761 aaaagcattc caaacattca aaaatagttg gaacttccct taataaatcc gtcactttct
    38821 ttttcaagat agcccaagct tgctcaatag gattcaaatc cggtgaataa ggtggtagag
    38881 gtaagaaaaa gtgtttatct tggatgcaga gttcatccaa aatgttcttg ggatgaaaac
    38941 tagcattgcc catgacaata acatgaggtg tcttcaaagc aggtaggagt tgcgttttga
    39001 accactccac aaagaaatcg cttgtcatgc ttttcttgta aatcatggga gctataaact
    39061 ctccgtctac ttgtcctgca acaattgaag ttcgctcaaa acgacgtccg ctaatctttt
    39121 catagacttt ctcccctcta ggagcccctg cataaggacg atagaggtag cggtcgattc
    39181 ctgtttcgtc aatatatacg attggtaaat cttttaggtt atccaaaata tcaagaaact
    39241 cagcgacttt ctctggctct tgttccttaa agctcgtcat ctttttttaa agtgacctta
    39301 atctgcttta aagctgccca tactgaagga acagcacaat caaaatgtgc cgcaatttcc
    39361 cgtaaaaaag catctggatg agcctctaca aaggttttca attcctctaa aggaatcttt
    39421 cggtttttga cgactcgctt tttcctctct atgtgttctt gttcacatct ttcttttccc
    39481 acgtgaagag agttctgacg ccaacaccaa aaaacttggc tgcctcgaca tggctgtgcc
    39541 cctctttgat gtaatctaat gctcgctgtt taaaatcagt actatatgcc atagctttat
    39601 tataatatgc ttgtttaaaa ctaagcaact atatcaatgt tttgttatga gaagacttac
    39661 tttttttact gaaattgaat ttttcctagc ctcaacatca tataacccca aaattcaatc
    39721 tgacctggtt tgaagagatg ttcgaagcag ataaggtttt actaaaacta aaaaaaatga
    39781 tataatcaaa ctgattaaat gttttaaaaa taaaggagaa tttgaatgtc ttaccaagaa
    39841 aattaccaga aatgggttga ttttgtggag cttcctgact accttcgtca agatttggaa
    39901 aatatggacg aaaaaactaa ggaagatgcc ttctatacaa atcttgaatt tggtactgca
    39961 ggtatgcgtg gcttggttgg tgctggtaca aaccgtatca acatctacgt tgttcgccaa
    40021 gctactgaag gattggctcg tttgattgag tcaaaaggtg gaaacgagaa agaacgcggt
    40081 gtagcaattg cctacgatag ccgtcacttc tcacctgagt ttgcctttga atctgcggca
    40141 gttcttgcta aacacggcat caaatcttac gtatttgaaa gccttcgtcc gactccagaa
    40201 ctatcatttg cagttcgtca tctcaactgt ttcgcaggta tcatggtcac agccagccac
    40261 aaccctgctc catttaacgg ttacaaggtt tacggtgaag acggtggaca aatgcctcca
    40321 cacgatgcgg acgctttgac tacttatatc cgtgcaatcg aaaacccatt tgcagttgaa
    40381 gttgctgatg tggaaactga aaaagcttct ggcttgattg aagttatcgg cgaagctgtt
    40441 gacatagaat accttaaaga ggttaaggac ataaacatca acccagcctt gattgaagaa
    40501 tttggtaaag acatgaagat tgtctacaca ccacttcatg gtactggtga aatgttggct
    40561 cgtcgtgctc ttgcccaagc aggatttgac tctgttcaag ttgttgaagc gcaagcaact
    40621 gctgacccag acttctcaac tgtaacatct ccaaacccag aaagccaagc agcctttgcc
    40681 cttgctgaag aacttggtcg tcaagttggt gcagatgttc ttgtcgcaac tgacccagac
    40741 gctgaccgtg ttggtgttga agttcttcaa aaagatggta gctacctcaa cctttcaggt
    40801 aaccaaatcg gtgctatcat ggctaaatac atcttggaag ctcacaaaaa cgctggaact
    40861 cttcctgaaa atgccgctct ctgcaaatct atcgtttcaa ctgacttggt aacgaagatt
    40921 gctgaaagct acggcgcaac tatgttcaac gtcttgacag gtttcaaatt tatcgctgaa
    40981 aaaatccaag aattcgaaga aaaacacaac cacacttaca tgatgggatt tgaagaaagc
    41041 ttcggttact tgattaaacc atttgtacgt gataaagatg ccatccaagc cgttcttgtc
    41101 gttgctgaac ttgctgccta ctaccgttct cgtggtttga cacttgctga cggtatcgaa
    41161 gaaatctata aagaatatgg ctactacgca gaaaaaacaa tctctgttac tctttcaggt
    41221 gtcgatggtg ctgaacaaat caaagcgatt atggctaaat tccgcaacaa tgctccaaca
    41281 gaatggaacg caacagctat cactgtcgta gaagacttca aggcacaaac tgctactgtt
    41341 gctgacggta ctgttacaaa cttgacaact cctccaagtg atgtgttgaa atacacactt
    41401 gctgacggtt catggattgc cgttcgccct tcaggtacag aaccaaaaat caagttctac
    41461 attgcagttg taggggaaac caacgaagaa tcacaagcta agattactaa catcgaagca
    41521 gaaatcaatg catttgtaaa ataaagacct ataaaagatg agaccaacca acctcatctt
    41581 ttttcgtatc aaatctaagc aattttagaa actttatggc atactagact tatcaatgaa
    41641 agcgaggtaa tctcatggaa caatttttag ataacatcaa agaccttgaa gtcactacag
    41701 ttgtgcgtgc gcaagaagct cttgataaaa aagaaactgc aaccttcttt atcggtcgca
    41761 aaacttgccc ttactgccgt aaatttgcag gtacattgtc aggtgtcgta gctgaaacca
    41821 aagctcacat ttacttcatc aatagtgaag aaccaagcca actcaatgat ttgcaagcat
    41881 tccgctcacg ctatggaatc ccaactgtac caggttttgt tcatattaca gatggacaaa
    41941 tcaacgtccg ttgcgactct tcaatgtcag cacaagaaat caaagatttc gcaggattgt
    42001 aaaaaatcag ctaacaagtc ttaaaatcac aaaaacgcat aatgtaaggt gcaaaaacct
    42061 tgatattatg cgttttattg ttcctaaaac agttacatca gcatttcatt acagaacatt
    42121 ttaattttgg aagtcaaatc aatttttaac aatgttttag aaatcacagt gggctattcc
    42181 atattcaatt atccagattc aatcgctatt atcgttttcc tagattacaa aaaaactacg
    42241 ttttgctaat caaaacgcag tttcagccac tattttatct tactgtcctt cttttacttc
    42301 tttggttgct acatcttctc caaaccattt ttggctgatt tcttggaact tgccgtcctt
    42361 gtaaagacta gaaaaagctt catttatctt cttaaccaag tttgtatctt ccttacgggc
    42421 tccaaccgca aaagcttctg tttctagtcc aactgtaaag acattataat cgtttaaaac
    42481 accttctgct tctaaataat agtttgcata gacacggtca atcaatagac catcaattcg
    42541 atcgtttttc aaatcaatca aggcttcatt aaaggtttgg tattgattcg cttccttatt
    42601 agcgacaata ttcttcaaaa tttctggatt tgcttcaaag tccgcataac cagatgaacc
    42661 agcttgagct cctaatgtct ttccagtcat atcctttgca gtcgtgatac cagatgattt
    42721 cttcgtaacc aatacctgct cattcttcat atatgagtta ctgaaagcca ccttttcacg
    42781 gcgttcgtct gtagcggaat agccattcca aatcagatca atcgttcctt ttgtcaattc
    42841 agcttctttc aaatcccaat caatcggttg ccaatttacc gtgattccgt atttttcaaa
    42901 aacagctgta gctaaatcaa tatcaaatcc tgcataagaa ccatctttct gagcaaatcc
    42961 cattggaaca aaagtactat caaatccaat agtaatagac ttgttagact ggtactttga
    43021 ccaattatct ccactagttt cgctagaatt tttcccacaa gctactaaga acaaagcagt
    43081 catcagactg actaatacaa gcatccattt tttcatccat ttttcctcct atttaggttc
    43141 tactttcaat aatacatctg cgatattttc agcaaactgc aaatcatggg taaccacaat
    43201 ctgggtcatc ccaagttccc tattttgcaa gattagcttc tccacttcca aacgtaattc
    43261 tggatccagg gcagaagttg gttcatcgta gccaatgatt tctgggtcaa tcatcatagc
    43321 acgcgccaaa gccacccgct gcttttgccc accagatagt gagaaaggat aggcctctgc
    43381 gtgtcctcct agtcctaact gttccaagag tccactcgcc ttcttctcag cctcttcctg
    43441 cttcattccc atggtcttca caggcgataa agtcaaattt tccagaactg ataaatgagg
    43501 gaacagttga aaatcttgga atacaaatcc cagtagattg cgcttctgca attcatccag
    43561 ctctaaaggt tgtccattat aaaagatttg ccctgaatca atggtttcaa gacctgcaag
    43621 catacgtaaa agagttgtct tacctccacc agaaggtcca acgatagcca ggatttgctt
    43681 ttcaggaata cttagactga aattagacag gatttgtttg tctccaaaga ctttattgat
    43741 atttcgtaat tctaacatgg cagcctccta tctataataa ctatacttct tctcaacttt
    43801 tttggaaata attgtcacaa tcccaatcaa aatcaaataa atggctcctg ccaagaacat
    43861 aggaactaga ctagcatcgc ggttagcagc tgttcgacta gccaagataa ggtctgaaat
    43921 tccgagagca tagaccaaag aagtatcctt gaccaaactc ataacttcat taaagacact
    43981 aggaagaacg atcttggtca cttggggcaa gataatatag cgcactctgt caaaagggct
    44041 aaacttcaag accttggcgg cctcatactg tcctcttgga atagtgtcaa ttcccccacg
    44101 gaaaatttct gcaaagtaag ctgcatagtt gagaacaaag gcaataatag ctgcaggaag
    44161 gcggtctaaa cgaatcccaa tacttgggag cacataatag ataaaaatca gttgcaagag
    44221 taagggggtt cctcgcataa cccagatgta aatgttaatc agataatgga ggggcttcca
    44281 atggacttgc aaggcaaagg caatcaaaac gcccaaggga atcgaaaata gcaagaccag
    44341 tgcaaagacc tgtacagtcg tgctcgcacc attcagtaaa ctcggtaata tctcaaataa
    44401 ataagacata ctgcacctcc taaaagtaat tgttcctatt atagcatgaa taaacaagat
    44461 taccaagtat ttttgtaaaa agattctacc atatacaaat aaaaaccgta gctatcaaaa
    44521 gagataaact acagttctat atgtttaaac attcttacaa tctctcaaac agttcttgca
    44581 tttgcacatc atctggaacc agttttaagt aagtgtgagc atggactttt gcttcttcaa
    44641 aatgtcccaa ttcacgcaag agatagatat agtgttccag aaattctgga ttgtccttca
    44701 aatctcctgt caactcttga taatgctcat aagcagtatc caaatcgtcc atttcttgat
    44761 aagaacgagc aatcatccac ttggtcaaaa gattttctgg ctcctcactc tgcaagtcta
    44821 gaatatcctc ataacgctcc tgctccagat aaatagtggc taaacgaagc aagatttctt
    44881 ctgtatcctc agcgtcttct tttgcagcaa gaagataatt ttctgcacca ctagcatcat
    44941 gcaattcata agaaaattgt gaagcagcta gcaagaggcg agtttcaaag ggatttttct
    45001 ctaatccttg cttagcgata cgcagggctt cttgaacttg atgttcctta tgtaaagcct
    45061 gactgtaccc atactcatag ccttcaaagt caggagaaat ggtatcaagc tgcttaaagt
    45121 agagggtggc tttttgatat tcttcttgat caaaataaag atttgccaac tcaaaagctg
    45181 ttaagtcatc gtattctaac tccagggctt tttctaaaaa ctcagtagcc gtttcaaatt
    45241 tccctaactg agcataggca aagccaattc gttgataggt ggaaatgccc gtttgctcat
    45301 aaatcgagcg attatctaac tgggcatagg cttgaatagc cgcttggtaa ttttccaact
    45361 cactatccaa ctctgccaaa cccaatatca agagagaatc ctctgagtag gtcaaggcct
    45421 ccaataattt ctcacgtgcc acatctgtca aaccttccag ctggtaaagg tctgccttca
    45481 gagccaaaga cgagacatac cagtcactgt cagcttggat ttcctcaaga taggtaaagg
    45541 cttcttctat ttgaccatcc tcgctagcaa ttgcagctag attaagatga acctctggaa
    45601 aatcctctac aattttcagg taaatttcct tggcctgagg atagaaacca atcccttcaa
    45661 gataagttgc caactcatac agaagatcac ttgaatcatt ttctaaagct ttggcgaaat
    45721 aatgctcagc cttagttaaa tcttgctcct ccaaagcctg taacatctgt tgactattgt
    45781 tcactcttga cttcctcacc ctctaattca tatagaccac tgactacctt ataccattcg
    45841 aaaatggctg aaatgacaac cttagcagag gcataaaccg gaataccaag taaaactccc
    45901 cagataccaa acatagatcc tgaagttaac aaaacaaaga gaacattaat aggatggatg
    45961 tttaattgac ttcccaaaat caatggagag acaaaacggc cttcaatagt ttgttctacg
    46021 ataaagacaa tcactacttt caaaagcatg actggaccag caatcaaacc caatactaga
    46081 gcaggaaaca tggctagaaa gctaccaaga taagggacca gatttaaaat accagcagta
    46141 acccccagcg taaccgcata gcgtagacca ataatcttga agaagatgat aaacattact
    46201 gctacaataa tagccactgt cacttgccct cgaacatagt tggacaactg ttgattcaca
    46261 tctgatagaa cttgtccaac aggttccttc aattttcttg gaatgaattg ggtcaaatag
    46321 ttacgcaagc ctttcccatc acgcaagaga taaaagagca tgaaaggaac gataatcaag
    46381 gcaacaatca cttgagaagc tccgctaata aaggcactca cccagttgac tgcctgagat
    46441 gaaaccttac ttgccaaaac tgtagcctgg ctagaaaaat tggtcaaaac ttgctctaat
    46501 tgaggtctga aatcatctgg caggtgctgg gctaccaatc cattaacaat cctatctata
    46561 tcttctaagt aaacaggaac gtttcttgca aaggtcaaaa cctgacgttg cagatttgga
    46621 atggcgactg ccaagcccca aatgataaag agagcgatga taacaaagac aatagtgata
    46681 gctataacac gattaacctt atgcttctcc atccaatcaa caataggatt caacaaataa
    46741 tataacaaac cagacaaaat gactggcaac atcacaactg ccaaaaagtc taaaacaggt
    46801 gaaaatagaa aactaatctt acttaaaata aaaagattca gtcccaataa taaggttact
    46861 aaaaataccg taattgcctt gttatctaaa aaccacttga aaaaccaaga taggctaaaa
    46921 tgtttctctt tttgctccat aaatacttcc tttctattgt tctctcatta taccattttt
    46981 gaaacaaaat aactcttttt taaagtgctt acatctaatt ggatatcttt aatttacttg
    47041 tttttgtgat ataatagtct tatctttaca cagaggtata gtaatgaaag aaactgttta
    47101 ttttggaact tatacacgtc gtacttctca agggatttac aaggcagact ttgatacaga
    47161 aactggtcag ctttcaaatc tagaactttt tgcagctgag ccgagtccaa cctaccttgc
    47221 ctttgaccag caccaacatt tatacactgt tggtagccaa gacgataagg ggggaattgc
    47281 agcctatcaa actgacggga ctgtgttaaa tcatgttgtt gaagaaggag ctccccactg
    47341 ttatgttgct gtcgatgaaa agcgtgattt ggtttacgca gccaactatc acaagggaca
    47401 agtccttgtt tataaacgcc aggaagatgg tagtcttcta cttagtgata tggatcaaca
    47461 cagtggccaa ggtccacatg aaaatcaagc ttccccccat gttcactata cagatttaac
    47521 acctgaccac tatctagtga cctgcgactt gggaactgac caagtcatca cctatgacct
    47581 cgatcaagaa ggaaaattat ctaagctcta tacctatcac agcaagccag gagcaggctc
    47641 acgccatatc attttccata accactataa aatcgcttat ctcatttgtg aactcaatag
    47701 tactatcgaa gttttaatct acgatggcgt tggcgaattt gaacgtatgc aggttatttc
    47761 aactttacca gaagcttacg aaggctttaa tggaaccgct gctattcatc tctctaaaga
    47821 cggtaaatac ctctacgctt ctaaccgtgg ccatgattct atcgcagtat ataccatcct
    47881 tgcggacggt agcttagagt tattagaaat cgttccaacg catggtcaga ctccacgtga
    47941 ttttgatttg acacccgacc aaaaatttct cattgttgtc catcaagact ctgacaatgc
    48001 aactgtcttt aaacgtaatt gtgacaatgg tcgtctagca gaactctcca acgacttcca
    48061 tgttcccgaa gcagtctgca tccgttttgc tccttaaaac accataaaaa atgaacttgg
    48121 tattttcaag ttcatttttt cttatagtct atttccgaca ttaatacggt taatggcacg
    48181 ttgcaaagca atcttagcac gacgttcttg gtcaatcaaa tgtttgtctt gtgcttcttc
    48241 aattgcacgt tctgcacgaa gtttggcacg ttctgcacgg ctaatatcga tatcacgagc
    48301 acgttctgca gagtcagcga cgattgtgat catatcattg gcaatttcaa taacgccacc
    48361 gtttactgca atccagttca cgtgatcttt atcatcgata cgttttacct ttacttcatc
    48421 aactgctaaa accgcaatca tattttcatg tcgtggcaag atccccatct caccatccag
    48481 agttcgaacc gatacatagc tggcatggtg atcatagacg agaccatctg gtgtcacgat
    48541 ctggacagtt aactgagcca taggtcacct cttaaaatcc cattttttca gcttttgcaa
    48601 tcacatcttc gatagaacct acaccacgga aggcatcttc tggcaagtgg tcgtatttac
    48661 catcaaggat ttccttaaag ccacgtacag tttcagcaac tggaacataa gaacctggct
    48721 gaccagtaaa ttgttccgca acgttgaagt tttgtgacaa gaagaactgg atacgacggg
    48781 cgcgagcaac caaggtcttt tcttcatcag aaagctcatc cataccaagg atagcaatga
    48841 tatcttgcaa ttcatggtaa cgttgaagga cacgttttac ttcagcagca actgcatagt
    48901 gctcttctcc aacgatttca ggtgccaagg cacgtgagct tgaagcaagt gggtcaacgg
    48961 ctgggtagat acccaattgt accaatttac gttccaagtt tgttgttgaa tccaagtgag
    49021 cgaaggctgt tgctggcgct gggtcagtat agtcatccgc tggcacatag atagcctgga
    49081 tagaggttac agaacccttc ttggttgatg tgatacgttc ttgcaattga cccatttccg
    49141 tagcaagtgt tggttggtaa ccaacggctg atggcatacg acccaaaagg gcagatactt
    49201 ctgaaccagc ctgagtgaaa cggaagatat tatcgataaa gagaagcacg tcttggcctt
    49261 ccacatcacg gaagtattca gcgattgtca aaccagtaag ggcaacacgc atacgtgctc
    49321 ctggtggctc attcatctga ccaaagacca tggctgtttt ctcgataacg cctgattctt
    49381 tcatttccca gtaaaggtca ttcccctcac gagtacgttc cccaacacca gtaaatactg
    49441 aaataccacc gtgctcttgg gcaatgttgt gaatcaattc ttggattaag acggttttac
    49501 caactccggc accaccgaaa agtccaactt taccaccttt aaggtaaggg gcaagaaggt
    49561 caataacctt gatccctgtt tcaaggattt cagaagaggt agacaactca tcaaaagttg
    49621 gagctttttt atgaattggc tgacgctctg cgtcttctgt aaaaggagct tccaaatcaa
    49681 tggtatctcc caaaacgttg aagacacgtc ccaaagtttc tttacctact ggtacagaga
    49741 ttggacgacc tgtgtccaat acttccattc cacgagtcaa cccatctgtt gattccatgg
    49801 cgatagtacg aaccatacca tctcctaact ccaaggctac ttcaaggacg atttttgttt
    49861 ttctttcgtc atttttgtag acgacaagtg cattgttaat ctcaggaagt ttttcccctg
    49921 ctgcaaacaa aacgtctaca acgggaccga taacctgagc aattttacct gaactcatct
    49981 ccttctccta ttctatataa gatactgtcg gttcctagct caactaggtc ctaagttcat
    50041 tttcatacga gctggactag agcctattct aaggcactag cacctgctac gatttctgta
    50101 atttcttgtg taatcgccgc ctgtctggca cggttatact gaattgtcaa atcattgatg
    50161 actttcttag cattatctgt cgctgtttgc atggctgtca tacccgcagc attctcagct
    50221 gtcttggcat cgataatggc accgtaaatc atactttctg caaactgagg caacaactgc
    50281 tccagaattt cttctcggct ggtttccaat tcaaaagtca agctgtactc ttcatccgct
    50341 tcatttggat ccaagtcaac aatcggaagc atttgttcca cacgcatttg actggttagc
    50401 gtattgacat ggtggttgta gcaaacataa agctcatcaa agagttcatt ttggtacatt
    50461 tcaacagttt ttgaaataat cttacgaact tgatcaaagc taggttggtc tgccaagcca
    50521 cgtaattcat aaagtggttg aataccgcga gccttaaaga aatcagctcc catcccaccg
    50581 atacagatca tttcaaaacc tttaccgtct gggtggtatt cttctttcaa ctccataaca
    50641 gctttcaaaa tagaggaatt ataacctcca accaaaccgc ggtctgaagt gataacgata
    50701 tagcctgtct tcttcacaga acgactaatc aacatcggat tagttgaagc accagctcca
    50761 ttaccatgaa ggatatctgt caaaagttta cgcactttct gagcgtaaac ttggaagttg
    50821 cgagcagctt cttcagagcg acctagctta gcagccgata ccatttgcat ggcattagtg
    50881 atttgactcg tattttttgt tgaggcgatt tttgttttaa tatcatttag agacactgcc
    50941 atctgacacc tctattctta ttggaagcta gattgattga gaaactctgt aatcgcagca
    51001 tccaagactg cttcttctgg caagtctttt gtatcacgaa tggtttccaa aatctctgga
    51061 tgttgagcat caaagaaggc atggaactct tcctcgaaac gaacaatatc atctactgga
    51121 acagtatcca agaaaccatg tgtcaaagca taaagaatgg ttacttgttt ctcaacaggt
    51181 aatggtttgt gaacaggttg tttcaagacc tcaacggtac gacgtccacg gttcaactta
    51241 gcctgtgttg ctgcgtccaa gtcagaacca aacttagtaa aggcttctaa ctcacggtat
    51301 gaagcaaggt cgatacgaag tgtaccagca accttcttca tggctttgat ttgtgcagaa
    51361 ccacctacac gagatacaga tgaacccgca tcgatggctg gacgaatacc tgcattgaag
    51421 aggccatcgc caaggaagat ttgtccatca gtgatagaaa tcacgttggt tgcgatatag
    51481 gctgagatat ctcctgcttg tgtctcgata aatggtaggg ctgtaattga tccaccacca
    51541 agttcatcag aaactttagc tgagcgctca agcaaacggc tgtggagata gaaaacatcc
    51601 cctgggaagg cttcacgacc tggaggacga cgaagcaaga gcgatagttc acgataagct
    51661 accgcttgtt ttgatagatc atcgtataca atcaaaacat gcttaccttg atacataaat
    51721 tcttccgcca tagcaacccc agtataagga gctaggaaga gcaatggaga tggttgtgaa
    51781 gcagaggctg tcacaacgat tgtgtagtcc aaggcaccgt actgacgaag tgtttctact
    51841 tgcgtacgaa ctgttgattc tttttgtcca atcgcgacgt agatacagat catatcttga
    51901 tctttttggt tcaagattgt atcaatcgca atggttgttt tccctgtctg acggtcaccg
    51961 ataatcaact cacgttgacc acgaccaatc ggtacaaggg cgtcaatagc tttcaaacca
    52021 gtttgcaatg gttctgaaac agacttacgt tgcataacac caggagctgg tgcttctact
    52081 ggacgagttt tatcagtgtg gatttctcca agaccgtcaa ctggacgacc aagcggatcc
    52141 acaacacgac caatcagact ttcacctaca gggacttcca tgattttccc tgtacggcgg
    52201 attgtatcgc cttcacggat atctgtaaag tcacctagga tgataatacc aacgtctgtt
    52261 gactccaagt tttgagccat accataagag ccgttttcaa aattcaacaa ctctccactc
    52321 atgacatttt caaggccatg agcacgcgcg ataccgtccc cgatataggt tacaacacct
    52381 gtttcagtca catcaaaatt gggtttgaaa ttttcaattt gttgcttaat taaagcgctg
    52441 atttcttgtg cgttaattgc caaaagaaca ccactttcta tttcaaattt tctttaacaa
    52501 ctttaagttg ttgtttaata ctcacatcaa ttgtcttgtg attggcaaaa atgacaaaac
    52561 caccaatgag actttcatcg atttgttctt ttacactcct tactttcaga gacatttttt
    52621 tctcaatcaa agggagcaaa cgagtcttct gttcatcagt tagaggatga gcagacgtaa
    52681 tcgtcacttc aaatcgattt gtttcttttt caagtcggtt caagcaatct acaagcacat
    52741 cataaaaaag atttgctctg tgattgtagg ccagaacctg gataaagttt tgtaataaag
    52801 gcgacacaga atcttggaaa aaagcaattg ttttttcctt atccgactcg tctactgcca
    52861 cttgttttaa aaaagaaggc agacctgttt tttcaacaac ttgcttgatt tgagtcaagt
    52921 ctgaaaagat acggtcttct tctccttttt caagtaccaa ttggacaaaa ggcatgctgt
    52981 atttttcaat tacctttact gttttcttgt ccattaagct tctcctagct gatcgatata
    53041 ctgatcaatg agtgctttat gggcatgact gtcaaggttt tgtgagatga ttttaccagc
    53101 taagctgatg gtcaaatctg cgacctcacc cttaacactc tgtaaagctt ctactttatt
    53161 ttgagcaatt tcttgattgg ctttttcttt taagtgtcct gcttctagtt tagcatctgc
    53221 taagatatta gccttacttt gctcagctgt ttcctttgca ttttcaatga ttgtcttagc
    53281 ttctttacgg ctaccagcca attcatcttc gcgtttttga gccaatactt ctgctttttg
    53341 acgggcttct tcagctctgt caatatctga agcaattttt tcagctcttt cttcgaaaat
    53401 gcctgtaata ttagaccatg caaatttttt aatcaagact agcaaaagaa taaaagagcc
    53461 agtgattaaa ataaaattac caattaattc acctactgtt acgtgcatca gttactcctt
    53521 tctattcctc ttcaatatta atcttattcc ctaaatacac agatgtcaaa agagtaaaaa
    53581 cataagcttg gatgcaggaa ataaagacag aaaatgcagt ccaagccaaa ttagctccaa
    53641 aggctactgg ataccaataa atagcttggt gggaaagaag aagtaacaaa ctcgtcatga
    53701 cctctcctgc aaagatattc ccaaaaatcc gcaaagccaa agataagaag tttgtaaatt
    53761 cttccaagat attcatcggt atgacaaaaa caggactcat aaaagatttt atactttttt
    53821 taaatccacg acgacgaacg ctttctatat gtgtcaacaa aatgacaaga aaagataagg
    53881 ttaagtcata ctgtaaatta gcggttggcg aactccacca gttagtccca tcgatcgttt
    53941 gaatctttgt cattaagcca aggttattgg caatcaccat gaaaaggaat aaacaaagga
    54001 aaaagagtga gtaatctttc atgtagcgcg aaccaatgtt aggttctgta aatccaataa
    54061 caaagtcata gacatactca agtacatttt gctttccttt gggtttcaag gtcatattgc
    54121 ggcttgccca ataaataaag acaaaaataa ctcccacaat caacaaagtc atggctaaca
    54181 tagtcagatt gaagataaca ggaccaatag agatgattgg attaatactt tcttccatct
    54241 aaaatcctcc cttttcttct cgttccatgt atttatttga taataaatga gaagacaaga
    54301 gttacaaaga aagttccttc aataaaggca acacctaaaa acatcaaact acgaaactca
    54361 gaaagcatat ctggttggcg tgctactgat ttaaacagtc cattcatcaa taaaccttca
    54421 ccgacagata cgcccataca ggcaatacat aagcctaaaa atgttaaatt cataacaaat
    54481 tctcctttaa aataaaattt acttacttag tgtagtccta aaatttaaat ttgtcaactt
    54541 ttaaccgcta ttggaagcgt ttaataaaaa ttatttccat tttgctaaat ttcaagttca
    54601 agttagccat caagaagtct tctctgggtg acttgtagtc caagcatttt ttaggatagt
    54661 tgttaatcca cttttcgatg aatgcgactt ctttgggagt cattttcttg gttcccttag
    54721 gtaaccatct acgaatgagc ctgttgtgat tctcattagt tcccctttcc caagaggcat
    54781 aggggtgcgc ataatagatg tgctcctcag aaaacacatc aaacaagcga ttgaattccg
    54841 ttccattatc tgccgtgatg gaaagaatct tgtgttgttt taagatgagt tttagagcct
    54901 gattgaccac ctcagcactt ttatttggaa tcaatcggat gatctgatgt ctactctttc
    54961 gatccgtcaa gacaagcaag cagtagtttt ttgctctcgt aagtagaacc gtatcaatct
    55021 cataatgccc attctccaaa cgaagattga tagcttcagg ccgctgttcg atggattgac
    55081 cagcaggttt aaagttggtg ctggcctgtt tcttaagcgc ttttcctttt ctagggtaaa
    55141 gcagatcctg cttgctttac cccaattttc catgatgaat ccaatagtaa atggttgaaa
    55201 ttcccacgtt aaccccttta gccataacca tcatttcagg caaaaatttt tggttatgat
    55261 agtggagaat cttttccttt agttccttgg tcacgcttga tctcttgacc gagtgcttgc
    55321 gattattttc ataagactgt tgagcatagt cggcagaata aacctctttg aagcgccctt
    55381 ttccaagaca ttttcggact gtcctacgct tgattttagt gtggatagtt tgaggagctt
    55441 ttccaagcag agaggcaatt tctctatttg atttcccttt gttcgccttt tgtagtataa
    55501 tggttttgca tctctgtgcc tttcttgtgt ttgtggttga acaacaagta taacacagag
    55561 gtgttttctt atgcctacaa gagctttcat tatttccatt ttctttcgga tttcactcta
    55621 ttctgaaaaa cttgtgtata tttactgaag ctagcaagtc ttacctgtaa atttaatgaa
    55681 agcaacacaa aatccgagag gggaatctcg gattaatgtc aatttaaaaa gatagagagt
    55741 ttttagttta aataaattgt tttaaaatat caacaacatc acttcttttc ttaacctgat
    55801 aagccttgat tcctaatttt ggagctacga ttatattgtc ctcaatatcg tctagaaaga
    55861 cacaatttct aggttataac tggtatttat cgatagttac tcatatacat cagtccacct
    55921 ccatacttat gtgcgagcct ctctttgtat tatacctcca tactcacctt acagattctt
    55981 ttggtaataa tatctttgcc taatgtagag atagtcttgc aaagaaaaaa cttccttgta
    56041 gccatgtttc tgataaaagt ccggtgcctg gaactgataa gtattgacaa aggcaaaaca
    56101 acaatttcga ttcttagctt cactttctgc ctgttgcaat agttttgaac cgattccttg
    56161 ccctcgcagt tcctctttta caaacaaata ctcgatttct agccaatttc caaaagtctc
    56221 tgctatcaaa cccgcaagga gattgccctt ttcatcttcg acataaagat taagtggctc
    56281 actttcagcc tcttcccttt ttgaacggtt ataaacacga atcagattcc ctatttcttg
    56341 cgatttatgt gattccttat tttccaatct aaagtataat gaaatgaaat aaaacatgcg
    56401 caaatcgatt aaggaattta atctaatttc taataatgtc ttagaaatca aagtttacta
    56461 ttttaacttc aatgcactat acatctaata ctcaatgaaa atcaaagagc aaactaggaa
    56521 actagccgca ggttgctcaa aacactgttt tgaggttgta gatagaactg acgaagtcag
    56581 ctcaaaacat ggttttgagg ttgtagatag aactgacgaa gtcagctcaa aacatggttt
    56641 tgaggttgta gatgaaactg acgaagtcag taaccatata tacggcaagg cgacgctgac
    56701 gtggtttgaa gagattttcg aagagtagca aaatggaaaa aggagtgagt gaagcacatc
    56761 gcctccccac tcctttttct gtttttaggc tgttttttca accttcaaga tttttacatc
    56821 atagctacca acaggcgttt caattgttgc tgtgtcacct gttttcttgc caatcaaggc
    56881 ctgcccaatt gggctttcat ttgaaacctt acctgcaaag gcatccgcac cagctgaacc
    56941 tacgataata taaacttctt cttcgtcctc gccaatttct tggatggtga ctgttttacc
    57001 aatcgctact tcgtcctggg caactgcgtc gctattgacg atttcagcat agcggatttt
    57061 tgtttctaag ctagagattt gtccttcgac aaaggcttgt tcatccttag ctgcttcgta
    57121 ctcactgttt tctgaaagat caccgtatga acgggcaatc ttaatgcgtt ctaccacttc
    57181 tggtcgacga accaatttca attcttctaa ttctttttca agtttctcct tttcctcaag
    57241 ggtcatagga tatgtttttt ctgccatttt tctcaacttt cttctgataa tattttctaa
    57301 agaaaattat gtgacgtatc acataatttt agtttgttta gtttaatttg ctgttgacat
    57361 gttcagcgac attgcggtcg tggtcttctt gattgttagc atagtagacc ttgccttctg
    57421 tgacatctgc tacaaagtag aggttatcgc tcttagtttg attgatgctt gactcaatcg
    57481 catccagact tggactatcg actggaccag gcatgagacc tacattttta taaacattat
    57541 aaggtgaatc aatgttggta tcaatcgcaa catcctcagc tagactgata ttttgcccca
    57601 gttttccttg ggcatacaag attgcaatat tactttgaag tggcatatca cgatttaaac
    57661 gattgtagaa tacacctgca atgagcttac gatcttctgt cttggcacct tctttttcga
    57721 ccaaggaagc aatggtcaac aactcattga cagtcaaatt tttagatttg atagtactat
    57781 agtaaggaga taggttctta tccatagcag ctaacatctc atcaatcaag ctctcaatag
    57841 ttgtgctttc cttgatagag tatgtagctg ggaaaaggta tccttccaaa cgataacgcg
    57901 caccgctgtc ttttacaggc aaactttcca gtaaagtagg atatttcgct actgcttgac
    57961 tgataaacgt ctcatcttga actttagcca agaaagcctc cgctgtcaaa gactctttga
    58021 agtcaccttg caattgaccc acagcttgag caatctgatc caaggtataa ccttctggaa
    58081 ttgtcaaagt cgcaagtaca ggttcttgcg gttcatctgt tccacctttt tgcaactctt
    58141 tgagtaagtc ttctgtactc atactctttt gcaaattgta gtaacctgct ttcaagtcgg
    58201 tataattttt atacttggca taaaaactaa aaatcagacc atgctttacc aaaccagctt
    58261 tttcaagcgt cgtaccgatt tcttgaacgt ttgaaccttc tggaattcca accgtcacat
    58321 atttcttaga attagcatcg ataggtaaca aagaatctag cacgtactgg taaccaaagt
    58381 aaccacctgc tgagagcaag gcaaggaata caaggaatga aatcacaaaa gctttcacat
    58441 gtgacttctt ctctttctta ggattaacgg gttttgctcc ttctctacgg ctacgacgtg
    58501 atgtatcgct gatgatatcc actgtttctg tagcaggcgt aggtgtttct ggacctgctt
    58561 gttctgcttt tttctctgcc gtcgtatagg aaacagctac ccttgttggg gtttcattgt
    58621 attctctttc aagtttctta ggtctaacag gacctggacc tggtcttgat ccactttctt
    58681 ccgctggaga agaaggtaca tcttgacttg gatgacttgg aacaccagga gtttctcttt
    58741 gaatctcatc tgctggagaa gctggtacac cttgacttgg gtgagtagac acggtaggag
    58801 cttttctcat aatctcctct accgttgaca aggaatcagc catgagttct tcagctgaag
    58861 gttcatttgc aggagtgcga actactgcct catcttcttt cagaacttca tcatagcctt
    58921 ttactttttc taaatctctc agaatctgct ctttaaagct taatttctct tcttctcttg
    58981 acttttcact caaaagtttt tcctccttgt tgataatcca taatattata tcttaaaagt
    59041 ccaaaaaaag caatctatga tacttttcct aacttatttt ttcatttccc agaccatatc
    59101 ataccatgtt tcccctgcaa aggttgactg ggactggcct tcgttgacaa atccatgttt
    59161 ttcatagtag gcgatgagat agtcatgaca ggttagatta atgccatctc tctcatcttc
    59221 aagagcaact tctttcaagg ctgtcagcaa tttctgaccc agtccgagtc cctgtgcctc
    59281 cttggcaata gacagacagg tcacagagat ataaccacca ggctcatgac tatagtcttt
    59341 tatttcttct gtaaaagact ggtcttgcag atggcggtgc aggccaactg gtccttcgat
    59401 ataacccatg attcttcctt ctttttcagc aaccagaaaa gaggtctgaa tttctctcaa
    59461 atgtgcttca aagacagaag gaggaatggc ttcttcgacc gaaaaatttt caaattcaag
    59521 ttcaacaatc cgatccaaat cttctaatct tgcttgtctg attttcattg ttcctccaga
    59581 taaaagggat taaaccaaat catactatag ccctggctag ttgcatagag caaagttgct
    59641 tcttcatcaa caaaaccgtt catttcaaaa taggaaagca gctcatcagg actctccaaa
    59701 cgaatccctt tgtaatccag ctcaactgcc acctctttca aggctgcaag aagaagtgtt
    59761 cccaagccct gtctctgatg gtcagactcg atgactaaag aatgtacttt tagatattgc
    59821 ggattgtctg actggggact tgataaaata tagcctaaaa gttgattttc atccctagct
    59881 agaagaaagg tatccgcaca cttacggata ctttcttcta aaatatggga aagttgctgc
    59941 ttttcagctg gaaaagacga ggtctgaagt gcccctatct caggcaaatc agacttgctt
    60001 gcctgaatga tcttaattgg aatttccatg ggaacatcct attgaacatt gcttgtcaag
    60061 ttagacaaga gacgctcaaa tgagtattca taggtttgga tgtctcctgc tcccataaag
    60121 acgtaaacag cattgtcatg gtctaggagc ggagaaacat tttcaacagt aatcacttgg
    60181 tgttttttgt tgattttgtt ggctaggtct tctaccttaa cgtcaccatg atctacttca
    60241 cgagccgagc cataaatttg cgctagataa acagcatctg cttggtttaa agcatgggca
    60301 aagtcgtcca acaaggcaat ggttcttgta aaggtatgcg gttgaaagac tgctacaatt
    60361 tccttgcttg ggtatttctg acgagccgca tccaaggtcg caataatttc tgttggatgg
    60421 tgggcaaagt catcgataat cactgtatca ttgacaattt tctcagtgaa acgacgttta
    60481 acaccggcaa atgttttcaa gtgctcacgc accaagttca aatcaaatcc tgctgtgtaa
    60541 agaagaccaa taacggctgt cgcattcatg atattgtgac gaccaaaggt tggaatgtgg
    60601 aattgcccca agttttgtcc acggaaatga acggtgaagg ttgaaccagt tattgaacga
    60661 agaagatcac tagctacaaa gtcattgcct tcaacttcaa aaccataata ataaattggt
    60721 gcatcagacg taatcttacg caattcagca tcttcaccat agacaaaaag acccttggtg
    60781 atttgtttgg catagtcgtt aaaggcatta aaaacatcct cgagacttgt gaaataatct
    60841 ggatggtcaa agtcaatgtt ggtgataata gagtattctg ggtggtaagg catgaagtga
    60901 cgctcatatt cgtcagattc aaagacaaaa tatttggcat tggccgaacc acgacctgtc
    60961 ccatctccaa tcaagaagct ggtatctgta atgtgagaca agacatgaga caacatacct
    61021 gtcgttgaag tttttccatg tgctcctgct actcccatgc taacaaagtc acgcataaag
    61081 ctacctagaa actcatggta acgtttgtag ctgataccat tttggtccgc ataggcaatt
    61141 tcgacgttgt tatctggacg aaaggcattt ccagcgataa tttccatatc accgtctaga
    61201 ttcttttcat caaaaggaag aatggtaatt cctgcctgct caagaccgcg ttgggtaaag
    61261 tagtactttt caacatctga tccctgaacc ttgtgcccca tctggtgcaa catcaaggcc
    61321 aaggcactca tccctgatcc cttaattccg ataaaatgat atgtctttga catgttttct
    61381 cccctattct gtcattctgg tcagattcaa ctcttgggca acccgacgtt cttgttctgt
    61441 ttgtttactt tttttattgt agatttggct cttctttaga aaatcataat tgtttttctt
    61501 tggagcaggt gctgacactt cttcattctt ggtagggata gaatgaactt cttccgccaa
    61561 gatataatga gactgggtca atttttggct atatttgaca aattcaccag gattttcctt
    61621 ttggaaagga gttgtcggtt gattgccctg tctaactaga ctgggctgag aatgacgtct
    61681 cgcaaggctg aaatcctgag ttaggtagtt agcagagcgt ttctttttca agtccgcacg
    61741 cgcttcttca cgcgccacct ccgcatagct ctttccttct tttttaaccc ctaaaggagc
    61801 ctttttaggt ttttcgactt gcttttcaat cggttttact ggtttttctt cagcaatagg
    61861 agcccattct aaataatttt tatctcgata ctcacccttg atattactga tcagatcaga
    61921 ctcatcatag agattcatga ctggcatttc agtcaacatg acctcgtcat ctgacaccaa
    61981 tggaaatcgt tcttgtttca ttttctattt cctttcaaca cttcattata gcgtattgtc
    62041 ttgatttttc aagtgctggc ttcagaaatt cccaaaattt ctctaatttc tgctagggtc
    62101 agactaccac gtgactctgt gccgtccaat acttgtgaca ccagatgttt cttttgttct
    62161 tggagttcct gaattttttc ttcaatggtt cccttggtca ccaagcgata gacctcaacc
    62221 gtttcttcct gacccatccg atgggcacgg ccaatggctt gcgcttccac cgcaggattc
    62281 caccaaaggt caaccaagat cactgtatct gcacctgtca ggttcagacc gaccccacca
    62341 gccttgaggg aaatcagaaa ggcatctctt tctccttggt taaaggcctt ggtcatgtct
    62401 tgtctttcct tggctggggt tgaacccgta attttaaagg aagtcaggcc caagtctggc
    62461 agttcttgtt caattttttc caacattccc ttgaactgag agaaaatcaa gacacggtgt
    62521 ccgccgtctg ccacctgtac cagtaggtct cggagactat ctagtttgcc gctggctccc
    62581 tgataatctt ccataaacag ggcaggagtg tcacatattt gacgcaagcg catcaaacca
    62641 gataaaattt ccacacgact tcgctgaaat tcctgttctg acacttgagc cagatggtct
    62701 cgcatctgtt gtaactgggc aaggtaaata gccttttgct ggtcttccag ttcattttta
    62761 taaaccacct caatcaagtc tggcaattca gtcagaactt cttctttctt gcgtcgcatc
    62821 acgaaaggct tgataaactg agccactcgc tctgctggca atttcataaa ttctttcttg
    62881 cttggcaaaa gtccgggcat gacgatttgg aaaatagacc acaactcacc cagatggttt
    62941 tcaatcggag ttcctgacaa ggcaaagacc gacggcacca caaattgtct caaggtctgg
    63001 gcaatcttgg tctgggcatt tttcatgacc tgagcttcat ctaagaaaag gaagtcaaag
    63061 gccatcccct gataaagctc actgtcctga cggaaggtgg catagctagt cacatagatt
    63121 tgatggctat cggcaagaat ctcctcacga cttgctttca aaccatgaac aacagccaca
    63181 tccaactgtg gggcaaattt ctgaaactca tccgcccagt tgtaaatcaa acccgacgga
    63241 gcgagaatca agactcgact ttcttttgtc acttgactag tcaaaaaagc aatggtctga
    63301 agggttttcc caagtcccat atcatcagcc aaaatcccac caaaaccata atgatggagc
    63361 atctgcaacc agccaattcc cttttcctga taatctcgca agtcagcctt gacctgagtt
    63421 gcttgcaaag gaaagtcctc tggatgcgtc aaatcctggg ccagattctg gaattcttgt
    63481 gaaaaagaaa cacggtctcg cccttcaaag agatgagcta aactgtaggc caaggatttc
    63541 cgagcctgca aggtcccatc ttttaattca aattgcccca gttcctgtag attttggcga
    63601 attttcttgg tttcttcatc gaaaaagtaa acttgattag acgaatcaat ataaaaatcc
    63661 tgattggcaa ccaaggcctg catggcttgg tcgatttcct cctgggcaat attttgaaaa
    63721 tcaaactgga tttccaagag acctcccttg gaggcaatct gcacctgagg actcgctagg
    63781 ctataaagct cttctagttt atctgatagg tcaacatgcc cgagtttttc aaagactgga
    63841 atgatatcat gaaaaaaatg atagacagac tccgctttta aggcctgacg ccaagattga
    63901 aaatcggctt caaagcccgc agccaaacag acttggaaaa ttctttcttc taagtccgcg
    63961 tcacttgaaa atggtaattc ttctagctct tgtcggctag atacctgtct atttccataa
    64021 tcaaactgaa tttctaaacg aatccgatta tcttcttccc tgtcaaagta aaaagagggc
    64081 gcaaaagttt tgatttgtag acgttctgga gctgaaacgg tgcccatctg gataaaaaga
    64141 gtcagacagg aggccaattt gtctcgatca ctgctatcaa attgcaggta tttctttcct
    64201 tgttgaccca caggtaacac tttaatttcc ttgagaagac gcatctgctg gtctgttaaa
    64261 aaataaacct gacctttatg gaaaagtact gctccctgat aaaagacatt gaccctagga
    64321 ctctcactga tttccatttc aaaatagtcc gagtattctg ttactgtaaa ggcaaataga
    64381 ttggtatcag catgcatatc ctgaaaaagc agggtttggt agctatccac ttgatggtca
    64441 aattgaaaat ggggcaaggc catcagtaaa ttcacaccct gctcaaaaaa ggtcagaggg
    64501 aaaaagaggt gccgaccttg gttttggaaa aagaggtctg gaaccagccc ttcctccgtt
    64561 agtccgtgca agaaagtcaa aagttcttgg ctggcatcat caaaggcttc ccaagaaaga
    64621 gactcctcat aaatcttgcc aatcatatac gactttctct gctcgacaat ccttaaaaaa
    64681 agtggaatat cccgaatgac atagtatttt tgtctattga tttggccgat tctcagagtc
    64741 cacaagatat gattggttcc tgcttccacc tgacccacag ctgataactc ataggcgcat
    64801 tctgatttcg gagataaaat tcgattcaaa aacttgccac ccaaggtcac cttggtttca
    64861 acggcctctt tttcttcatg accttcttcc agactccaca agatttcctg accacgctca
    64921 tcatttttca gaaaatgctc tagcgctgcc aaatgcacac agtagcccct cttttgaaaa
    64981 gaatcacagg cacaaaaaac caaatcatcc tctaaactat agcgcagttc ttcttctgca
    65041 acgcgagcgt agagccgatt gttcttttcc ttgatgatat caaccttacc agtttcataa
    65101 agggcaacac cttcgatacg aactttcccc ggaatcaatt tagccatatt ttcaccttta
    65161 ccttatcttt ttattatacc atattttcgc ctatgaaaat agccttctag gaagactttt
    65221 ctcctagaag actggatttt taacgtttgg caaaagtagc cacaatccgc tgacagactt
    65281 cctgcaacag agatttgggc atagctatat tgatgcgggc atggagactt ccttcctctc
    65341 caaaatccaa accacggttg aggataacct tggattcatt tctcaacaac tcttgcaatg
    65401 tttcatcagt caggtcatag gctgaaaagt caagccaaat caagtaggta ccttgcggtt
    65461 tcatgacctt gattttagtc tcttttccaa atagatctac cacataattg atgtggtctt
    65521 caaagacttg cttgagttcc tctagccaat ctttaccgta tcgataggca gcttctgtcg
    65581 ccaaataacc caagcctgaa atttcatgct gattattggc caacaggcgt ttctggaaag
    65641 ccagtctcaa cttaggattt tcaatgactg cataggaatt ttttgttcca gcaatattaa
    65701 atgttttagt ggcactgctc aagacgatag caaaattttt gaaggcagga ttgatggtat
    65761 tgaaagactg gtgtttgtga ccaaagaggg tcaaatcttg gtgaatctca tccgaaacta
    65821 acaaaacacc gtgtttttgg cagagttggc caatcttctc caacacttct ttttcccaaa
    65881 cacgtccacc aggattgtga ggattgcaaa gaatatagag tttaacctcc tcttccacca
    65941 aatccttttc aagttggtca aagtcaatct caaacagacc atccttttcc actaaggaat
    66001 tagtaatcaa tctacgatta ttcaacttga cactgcgagc aaagggtggg tagacaggcg
    66061 tgttaattaa aaccgcctcg ccttcttttg taaaggtttg aatagctgtt gagatggctg
    66121 gtaccacacc ctcgataaag acaagagcct ctttgtcaaa gttgtaaccg tattgtgtag
    66181 cttcccactt ttgaacttcc ttaattaagt cttcactggc ataggtataa ccataaacca
    66241 gttggtctgc gtaagtttgc acggcttggc ggatttcagg caagaccaca aagtccatat
    66301 ccgctatcca agctggtaga acttcactat ccgtttctgt ttctttccat ttataggtat
    66361 ggtgccctaa acggttgggc aggcttgtaa aatcatattt tcccatcttt gtcttatcct
    66421 tctaaggctt ggcgcaaatc tgcaatcaaa tctctagcat cctcaatccc aatagacaaa
    66481 cgcaagaggt catctgtcaa accataagaa tggcgtactt ctgctggaat atcagcatga
    66541 gtttgagtcg ttggataagt aataagactt tccactccgc ccaaactttc cgcaaaagag
    66601 aagaccttga gactgttcaa aatatgagga atgcgtgttt catcggctac tttaaaggaa
    66661 atcatgcctc cacgaccagt gtagagaact tccttaactg ctggagaatc cttcaaaaag
    66721 gcaaccactt cttgggcgtt agctgttgag cgctccatac gaagagacaa ggtcttgaga
    66781 ccacgaagca actggtagct gtcaaatgga gacaagactg cccctgttgt attaagattg
    66841 taaaaaagct tctcgtatag ttctaaacta ttggtcacaa ccactccagc caagacatca
    66901 ttgtggcctg ctagatactt ggttgctgaa tggagaacga tatctgctcc atcttcaatc
    66961 ggacgttggt agatagggct atagaaggta ttgtccacca ccactttggc acccttagca
    67021 tgagccaatt ttgctagttt ttcgatatca aattccaaca tcaagggatt ggttggggtt
    67081 tcgatataga gaacatccac atccttttct aactcggcaa tcaactcttc ttctgtattg
    67141 gcataggtaa aatggaaacg accttcctgc tccacttggt taaaccagcg aaaagaacca
    67201 ccgtaaagat cacgcactgc caagacctta cttcctactg gaaagacgct aaaggccagt
    67261 acaatagctg acatccctga gctagtcgct agggcatagt ctgctgactc aatagccgca
    67321 aagacttcct cagccttact acgagttgga tttttagtgc gcgtatagtc aaacccagta
    67381 gatcgaccaa actctggatg ctgataggtc gttgaaaaat gaagcggtgt caccaatgca
    67441 cctgtcgctt catctgactt aatacccgcc tgggccaaaa ttgtgttaat gtgtaattcc
    67501 ttgctcatac aatacctcca aatctatagt aactattgta ccacttattt tcatcaactc
    67561 attttcttct tttcaagagc tagttatagt ttcaaactat ataaaaaggg agtttttcct
    67621 gctcccttta atagactata aaatggtgaa tctcaaaaga caccttcact ctatcatttg
    67681 ctcctgcaca aaacgagcat aacgctcatg attttccagt agttccttat gagttcctga
    67741 gccagtgatt ttcctctcct ctaagaagaa aatacaatcc acatctttta ccgttgacaa
    67801 acgatgcgct ataatcacaa ccgtcttctc ctttaatgca gaatagagga tactgataat
    67861 cgcatactca gaatacgcat caagattagc agtggattca tcaaatataa gaatttcagc
    67921 atcttttaag taggttctag ctatttgaag tctttggctt tgcccccctg acaagaatcg
    67981 tccgcgttca ccaacttcag tatctagtcc ctctttcatg gagcgaatct catcacctag
    68041 tgatactaag tctagcactt tcatcaattc atcatcagtt actaagcgat tcaaaccgag
    68101 acaaagattg tcacgaatac tgccagataa gactgcatta ttttgtgaaa cccaagcgat
    68161 tttacttctc cattctttta agttaaaatc atatatactt gattgctcca ttagaatatc
    68221 tcctgaaagc ggtttataaa actgctctaa caaacgcaca atcgttgatt ttcctgatcc
    68281 agatggtcca acaaaagcaa ttttttgccc cttgaaaatt gaacaagtaa tatcctttaa
    68341 gacaggtcga ttttcatcat aaccaaaata gacatggtta aaattcaacc cttgtcctga
    68401 taccgatttt cctcactcaa atttttcttt aggaactgca agcaagttct ccagtgcaac
    68461 tgaagatccc ttgctcctag aataaacagt tacaaaatta gctatattac taataggatt
    68521 aagtaattga aagaggtaaa tcaaaaacga aaccaaggtt cccacagata tatatcctgc
    68581 gctgacccga taacccccat aggttagcat cacagctata gtcgcaaaga taaataagag
    68641 agcaaacggg gtctcaaaag aagtaaccct atctgatttc agtgaattgt tttgtaccct
    68701 ttcaatacaa ttatccaaaa catcctgtac acttttctct gcttggttag tcttaattaa
    68761 ttcatgttct tgaatctttt cagtcaattg ccctgttaaa aatccgattt cctcctgtaa
    68821 acgacgacta tacttttcac tgatattgga aaggggcaag ataataaaca tcatacaagg
    68881 aagagtgatg aataaaagta gagaaagatt ccaatcaaga ctaaataaga ctacaatgga
    68941 accaagtacc ataactaaac tcagaataat atttgggaaa gtcgtaatta aaaactcacg
    69001 aatgacactc gtgtcattga caatggcaga agtcaactcc ccactttggc tcttatcaaa
    69061 gaaggatttc tctgcataaa tcaacccctc tatcactttt ttcctgattt ttgctatctt
    69121 tttttcaccc gattgactaa acagatagta accaatagaa gaaaacaagg cttgaccaat
    69181 aaaaatcaaa aacgattgaa atactttgga acctatattt tcaatagaac tcccatctat
    69241 taaacccttt aagataaggg gaagcaacaa agcaagtaga ctagacagaa caagtaagaa
    69301 actccccata atcaccttag tatctactct taataatttt aatttcataa atactcctta
    69361 taatatttca acggataaag tcgggaataa ctcaatttga ggataaaatc taataaatct
    69421 tcctataaca aaacgcataa catctaggat tttatatacc tgatattatg cgtttttaag
    69481 cacaaagact tcttacacaa acttatctac aattagattt tatttgacat gttttgccaa
    69541 ttcttcttgg gcttttttat tggattcttc tttttctttc aaccattttt ctctggcttt
    69601 tgcatattcg tctgttgtga caatcttatc ttgtactttg aggtatttat atgattcaac
    69661 cccttttgta ccggttaaac cataggcagc agcaaatggt acggttcttc tcaatgatgg
    69721 tgttccccca cgcgaaacac ttggaagaac taaagaacta tcaatcaacc aagcttgaat
    69781 atcagcatat ttctcataac gtttggctgg atcttgctct ttattagctt cttccaacat
    69841 ttgagtatag acatccagtc caactgcctt agccttgtca ttggcctcac caggctctag
    69901 tccaagattt tgcagaaatc ctccactatt agtattaaaa atatcgagat aggttgacgg
    69961 gtcttgataa tcaggtcccc aaccgccatg atataaatca tagtctttct gagcagctgt
    70021 ttgagcaaag tagcctgaac tgtcaaactc atctgatgtt aattgctgaa tgtcaatcac
    70081 tacattatca gaacctaaaa cagattcaat tgattgtttg atagaactaa ctccttgtat
    70141 gcctacttta tctgttactt ccacagtctt atccaagtgg attgggaatt gaacaccctt
    70201 tgcttcgagt tctttcttag cttccgcaaa cttagccttg gctttctcag gattgtagta
    70261 agggtcttga ccatccgcaa agttgatacc ttgccattcc ttaccatagt tgaccatctt
    70321 agaggctaca acttcaccaa agtcttttcc cttgatactg acaaagtttg gaggaaccac
    70381 taggttacgc aaaatctttg ttgcaccttc tttcccttca gactgagccc cataagatgt
    70441 tctgtcaaaa gcaaaattga tagcctgacg gaagttttta ttgagaactg cttcctgggt
    70501 cgatttcttt tcaatgtcac ttgttttaga agtataattg taagacttcc tatctaggtt
    70561 aaaattaaag aaatatgaag ttgaattttg catactatag atgatattgt ttttgtattt
    70621 ttctttaatc ccttcatagc tggagctgtt aggaaaaaga cgagccgtag tataagcacc
    70681 agctgtaaaa ttacgttcca gtgattcttg gtcgctacca tcatagtagg tcaatttcac
    70741 atcgtctaca aagacattat tagcatccca gtaattaggg tttttcttat attcaatagc
    70801 agattttgag acaagtgctt tcatcaagaa aggtccattg tacaaaatac tagatggatc
    70861 cgccttccca aaatcatccc cttttgattt caggaaatct gcattaacag gaaaaagtat
    70921 cgttgcaagt gtttttgaat tccagtaaag ttctggttta accaaagtat attgaaccgt
    70981 ttggtcatca agtgccttga caccgacagt tgaaaagtcg cttgttttac cagtgatata
    71041 gtcatccaaa ccagcaacag agtcctgcac tagatacaag gcttctgatt ttttatcagc
    71101 tgcatattgc aaacctgtca caaaatcctg ggcagttaca ggcgcatatt cttctccctc
    71161 agaagtaaac cacttggcat ccttacgaag tttgtaggta taggtcaaac cgtcctgaga
    71221 aacagtccaa tcctctgcta atgatggaat aatattccca tattggtcat tttctaataa
    71281 cccgtctacc aaatttgcaa caatatcgga tgttgctgcg cggttttctg ctagatagtt
    71341 caagctagat ggatcacttg aataaacata gttgtaggtt tttgacgccg tgctagaatt
    71401 tccacacgcg ctcaataaaa ctcctgtacc caggacaaga cctgccaagg ttagatattt
    71461 gctcttagac tttttcattt ccagaacctc ctgctttaaa tatttgtttt attatacaac
    71521 tcttggtttg tttagtcaat tgttttttcc aaaaaatcaa aaaaaacctc attttctatt
    71581 tttgaaagat aattttagct atttttacgc taaaaaagga ataagtttca agttctccta
    71641 aaagattgtt caacttattc cttttattta taaatgctac cttacgaaag cttaaatttt
    71701 gctcgcaggc gatctgcttg ggcttttcct attaccttat ctaacaaata ggtacgcaga
    71761 ctcataacca tataaagtcc accccccatg gcaccgacaa gagctacata aaagaagctc
    71821 cacaaacgtc cacttggttg gaagaaaaat cctaacagcc actggatggt tcctattaac
    71881 agaaacatga ctagggtcag caaactgatt aaaatggttc gcttcaaaat caccttgcgc
    71941 ttgacaccag ttactttaca aatatcccga tacatcaaga cgttaggaat gatgagagca
    72001 atggttgttg aaatcaaagg accataactg tggaagaggg cgatggtagg tagttgcaag
    72061 actagcttgg caatagaacc atagataaaa tagagaacgg cctttcggtt gcggaacatg
    72121 gcctgaagca ttggagacaa gaccatgtac aagcctaaaa taatagactg caaaactgca
    72181 aagacaaata agcccagagc caaactatct ggcttaccat agaagactgt atatagaggt
    72241 tctcctacca taaccactcc aaccgttgct ggtagcaaga acataaagag tagggtgaga
    72301 ctgtcctgaa ccagacgaga agctgctttc aagtccccct tgacatagtt ttccgtcaaa
    72361 agtggcaaac caacactccc aatcgaaacc cctacagaaa tcaaaatcat cgtgatttta
    72421 ttaggattgg ctgagaaata agaaaacatg acaaccaagt cctcattgct gtagttggta
    72481 aaccagctca tactattgat aaaggtcagc tgatccaaaa tctggaagag ctggatggca
    72541 gaccctgtca ggataaaagg aatggcttcc ttaatggtat caaccaagag acgcttactg
    72601 ttaatcttat ctcctgtttc aaagactctt ttgagtgaac cttcttgggc aaggaaataa
    72661 atcaagactg caaaactggc taccataccg acaaaggcag caaaggttga ttgggtaacg
    72721 gctgctagat aatctcctga accgagcttc ataatgataa aggttgctag gagcatccag
    72781 ataacacgaa tgacctgctc agcaatttgg ctcatggcat agggtttgag gttattcatc
    72841 ccttggaaaa atcctcggat aacactcata gacgggaaaa tcaagactcc ccaagccaag
    72901 ctttgcatga ttgggatcaa gtctttgccc acgccagaca agtctgctag ccaaggagca
    72961 aagacataca agactaaagc aaaaaccagg cctagtcctg tcataaagcc taagaagctc
    73021 cgaatcaggg caaagctatg ctcttcttct cgcatggtat tatacttggc aacttgcttg
    73081 gccaccgcaa ctggaatccc cgctgttgaa accaacaaga accaagcata gatattgtaa
    73141 cccatggtaa agagaccatt tgccttagct gcataagccc ccatccagat gtaccaaggg
    73201 ataatgtaaa cagccccgag taggcgactg ataaagttac tagccgttag ccaagcagtc
    73261 ccccgtaaca tctgggcctg ctggtgattg ttttcgtgcg acatagattc ctcattcaat
    73321 tttgatagct aggaaaaact ccttatcttc cattataaac ttttccttgt tacttgtaaa
    73381 tttacgactt tcggtttaca atagaaagta tgattaagat tgaaaccgta ttagatattt
    73441 taaagaaaga tggccttttt cgcgaaatta ttgaccaagg tcattaccac tacaactaca
    73501 gcaaagttat ttttgatagc atcagctacg acagccgaaa agtaacagaa gacactcttt
    73561 ttttcgcaaa aggcgctgcc tttaaaaaag aataccttct ttctgctata acacaaggat
    73621 tagcttggta tgtagctgaa aaggactacg aagtcggtat ccctgtcatc attgtgaacg
    73681 atataaagaa agccatgagt ttgattgcca tggagttcta tggtaatcca caggaaaaac
    73741 tcaaactcct tgcctttact ggtactaagg gtaagacaac agcagcctat ttcgcctata
    73801 acatcttatc tcaagggcat agacctgcta tgttgtcgac catgaacaca actcttgatg
    73861 gcgagacttt ctttaagtca gcgttgacaa cccctgagag tattgacctc tttgacatga
    73921 tgaatcaggc tgtgcaaaat gaccgtaccc acctcatcat ggaagtctcc agtcaagcct
    73981 atctggtcaa acgtgtctat ggtctaacct ttgatgtggg agttttccta aatatcagcc
    74041 cagaccatat cggcccgatt gaacacccta gctttgaaga ctatttctac cacaagcgtc
    74101 tcttgatgga aaatagccga gcagtcatca ttaacagtga catggaccac ttctcagtct
    74161 tgaaagaaca ggttgaagat caagaccatg atttctatgg tagccaattt gataaccaaa
    74221 tcgagaattc caaagccttt agcttttcag ctacgggtaa actcgctgga gattatgata
    74281 ttcaactcat tggcaacttc aaccaagaaa atgcagttgc tgctggactt gcttgtctcc
    74341 gtctcggagc aagtcttgag gacatcaaaa aaggcatcgc tgcaacccgc gttcctggtc
    74401 gtatggaagt cctcactcag aaaaatggag ccaaggtctt catcgactat gcccacaatg
    74461 gggatagtct gaaaaaactc atcaatgtgg ttgaaactca tcaaaccgga aagattgctc
    74521 tggttctggg atcaacagga aacaagggag aaagtcgtcg taaggacttt ggcctcctcc
    74581 tcaatcaaca ccctgagatt caagtctttc tgactgctga tgaccctaac tatgaagacc
    74641 caatggtcat tgcagatgaa attagtagct acatcaatca tcctgttgaa aagattgcgg
    74701 atcgccaaga agccatcaag gcggcaatgg ctatcacaaa tcacgaatta gatgcagtta
    74761 ttattgcggg taagggagcc gattgttacc aaatcatcca gggcaagaaa gaatcctacc
    74821 caggagatac agccgtcgca gaaaattatt tataagaata gaaaaaacgt ttttcaaacc
    74881 ttcaacggca ccttctacag caccttttgc gtcttctaca acgtcttttg ccttagcaac
    74941 tgttttttca acagctcctt caagttctgt cttgctgtct ccagtaactt taccaaaacc
    75001 ttctttgaca gcacctgttg cttgttccaa tttgttttca agtgacatat gattgtctcc
    75061 tttagtttat tccgatatgt gttaccggtt acatatagtt tataccgaat actaaggaaa
    75121 gtcaaacaat gttctcagaa acaagaaatc acgctaagta gaaagttaat ctctccttat
    75181 caaaatcgat agccaactca tactttctat cttcattttg cacaatatag cctaagacaa
    75241 ccaaactgtc cacaaagata tcacggcatt tctgcataag ctggtctttt ttgagaaatt
    75301 tcaacaaaaa agccgtcata tacttgaggg catactcagg attaacatct cctaaaatgt
    75361 catagagctc ctgctgtttt tctgtcaaag gatactgctg tttgaccttg taaaaataat
    75421 tggacagggt cattttaatg cgcgcaaagt ccgtcttttc aactaaaata gctgcattga
    75481 tttgattgcg caattccgtc tcaaaactct gctccaacaa ggcttgatag accggactag
    75541 cttctctgac aaaaatctct tgatccagtt caagactatc aagtgattca agcgtaggaa
    75601 aattaaggta atggcgctta ttttcacata gaatcacatc ctcatactgg tccagatagc
    75661 ggatcaattc tccaaaaatg gctgtctcgt caaacgagat ggattaaaaa tctgaatcac
    75721 gaagattcct ttctttacat tgtaacagag gcgatgctgc caactgacta ggattggtcc
    75781 cagcttggtt cagaggaaca ggcagaccta gttctatgta atactccctc caaaaatcac
    75841 taatctcctg ttccccatct ccaaatttca taggaatagt ttcaaaaata ggtaggattt
    75901 ctgctatata ctgggagcag tagaaaccag ctgcatctgg atagaaagaa gcattgtagg
    75961 gtgctccaag atgtttgcaa gctctttcct tcaccgactg gatatccatt tctgggtaaa
    76021 catagaggtc gtataaatga ttggactcaa agaagtctgc cggttcttga cagacaacac
    76081 cagcctgtcc actagcatga taaatcatcc catccaaata aatggcaaca tggctatagt
    76141 tacctgtgga agtctggatg gcctgtccca tgtctgaccc atctctcaca aaaatcaaat
    76201 cgccattttc taacatactt cactcctaga aaaaaggagc cgaaactcct ttcgatataa
    76261 ggcaaactag actttccgat tttgagctga cacccaaaat cttacgcatt aaagctttca
    76321 gtcaattgag gtaccacttg tttcttacgt gaaacggcac cagcaaggaa ggcatgattg
    76381 ttttcaagtt tgaagttgaa agccgcttcg accttgtcca tattggcacc aagagccaag
    76441 atttctgagt ttgagttgac gatatctgta atcatcaaga caaagtcaga gtagccgttt
    76501 gattcgttgg cagcttgcat tgcagcttca atttctgctt ggcgttccaa aacttcagcg
    76561 atgtcaactg tgttcacttg ggcaacacgg acattatttc cgttgagttc aaaagtctta
    76621 gcatcgatgt caatcaattc ttcagcagat ttgctagcca agttggtacc agctttcaac
    76681 attgccaaac catattcttc caagttcaca ccagccaatt cagccaattc aggagcaatg
    76741 attttatctg ttgggtgtgt tgttggtgat ttcaaaagaa gggtatctga aatcaaacct
    76801 gaaagcatca aacctgcaat ctctttaggc acagctacac catgttcttt gaacatacgg
    76861 taaacgattg aagacgctga tccaactggc tccaaacgca tgtaaagtgg gcttgcagtt
    76921 tcaaagttag ccacacggtg gtggtctaca acaccgtaaa cttctacttc agcgatatct
    76981 gatacagatt gttggaattc attgtggtca gtcaagataa cttgctctgc cccctctgct
    77041 ttggcagaag tgataacacg tggtgcttcc acaccaaaat agttcaagac aaaggctgtt
    77101 tcttcatttg gagttccaag ggcaacagct tccgtatcca aaccgtaagc ttcttttgca
    77161 aggtaggcaa aagctacaga tgatccgatg gcatctgagt ctggattttg gtgaccaaat
    77221 actagaatct tggacatgat aatacctcat tttgtttatt ttctttattg tagcattttt
    77281 ttcgcttttt gacaaaggta agaggagtca aaggactccc cacgattctt caaaataact
    77341 gagtaaattt ctatcttgat tttcagataa aaattcttcc ttctgtggcc tcttcttacg
    77401 cttgagaaga gcttcagccg acatggcttc ttccttactg gcaaaacctt gagcatagat
    77461 aagtttgact ggcaagcgtg ctcgtgtata tttggctccc ttcccactat tgtggatagc
    77521 gaggcgtctt ctcatatcag tcgtatagcc tatatagtag gatccatcac gacactccag
    77581 aacgtacata taagccttat gatccataat aaatctcttc gatttcgggc gtataagagc
    77641 catcatcatt gtggacaatc aaaggaggta agaccttaaa gccacttgtt gagccatcct
    77701 tgatcgcctc aatcaaaagc atattggctt ccttttctct ttttggataa acaaactgca
    77761 ggcgcttagg ggctagatta tgtcgtttta acgtatccaa aatatccaga agtcgatcag
    77821 gacgatgaac catggccaaa cgcccattag acttgagaat actctgggca ctatgacaga
    77881 tttcttccaa attagtcgtg atttcgtgtc gagccaagag ataatgttca ctctcgttca
    77941 gattagaata aggatccacc ttgaaatagg gtggattaca caaaatcata tccaccttac
    78001 tcccctgaat gtgagcaggc atatttttca aatcatcgca gatgacctgc atttgctcct
    78061 ctaatccatt caaacggaca gagcgttcag ccatatccgc caaacgctcc tgaatctcaa
    78121 cagacaatat ctgtgcttga gtacgagtgc tagcaaaaag ccccactgct ccattcccag
    78181 cacagaaatc cacaatcaac cccttcttag gaaaacgtgg aaatcgtgat aagagaacac
    78241 tatccaccga atagctaaaa acctctctat tttgaatgat tttgatatct gtcgaaaaga
    78301 gctggttaat gcgctctcct gattttaata attgttcttc ttccatggtc ctattatagc
    78361 aaatttatat taacattaca aaaaatataa aactctaaac tacttcttct tttttaaatg
    78421 gtgcagggct tctccagtcc agattggtag cattcgtcga aagggagcaa aaccgtagtt
    78481 aaagcggtcg cttgaaaagc gtctccgtct aggaaactgg tacttttctt cctccaaagt
    78541 gcggatagaa agactggctt tccctgtaaa ttcatctaaa tccactacct gaacttgaac
    78601 ctcttcatcg actttcaagg tttcatgaat attttcaata aatcctgtcc gaatctctga
    78661 aatgtgaatc agccccgtat cacccgtctc taactcaaca aaggcaccgt agggctgaat
    78721 ccctgtaata cgccccttta gcttatcacc gattttcatc ttagtcctcg atttcaatag
    78781 tttcaattac aacatcttca actggcttgt ccatagctcc tgtctcaaca gcagcaatga
    78841 catccaagac agcgtaagat gcttcatcag ctaactgacc aaaaaccgtg tgacggcggt
    78901 ctaggtgagg tgtcccacct tgattggcat agatttctgc aatcggttct ggccaaccac
    78961 cacgagtaat ttctttctta gaataaggta ggtgttggtt ttgcacgata aagaactggc
    79021 tgccgttggt atttggacca gcatttgcca tggaaagagc accacggata ttgtaaagct
    79081 cttctgagaa ttcatcctca aaagattcgc cgtagattga ctcgccaccc ataccagttc
    79141 cagttgggtc tccaccttgg atcataaagt ccttgataat acggtggaaa atgacaccat
    79201 catagtagcc atcttttgaa agagatacaa agttagccac tgttttagga gcatgttcag
    79261 ggaaaagctt gatacgtaag tctccgtgat tggtcttaat agtcgcaaga ggaccttcta
    79321 ctgtttcaat gtctacttgt ggaaaatgca attctttttc taccatacca aatacttcta
    79381 aggcatcaaa aatgccatct tcttctaatg tttttgtaat ataatctgct ttttctttga
    79441 ttttatcatg agaaattccc atggcaacgc tgattccagc ataatcaaag agttccaagt
    79501 cattgagacc atctccaaaa accatgacct tctctggttt caagccaagg tgttccacaa
    79561 ccttttccac ccccgtcgct ttggagcctg aaatcggcac aatatcagac gaatgttgat
    79621 gccaacgaac catgcgaagt ttgtctgaga gactgtcagg caagtgcaag tcatctccct
    79681 tatcttcaaa agtccacatc tgatagatat cttctttttc atggaaatcg ggatctacat
    79741 ctaagtcggg ataaattgga ttgatagctt cactcatcat atcggtgcga gtcgacaact
    79801 tggcatcatg actcccaacc aagccatact caattccttc ttgcttagcc caagagatat
    79861 actcctcaac atctgacttt tcaatctgat gctgataaat gacctgacct tttttatctt
    79921 cgatataagc cccattcaaa gttacaaaaa agtcaggctt gagatcacga atctctggaa
    79981 caacaccaaa aatgccacgt ccagaggcga ttcctgttaa aattcctttt tcacgcaact
    80041 gtttaaaaac agtgggaatt gtagttggaa taaaccctgt ctttgaattc cgcaatgtat
    80101 catcaatatc aaaaaagaca atcttgatct tctttgcctt gtatcttaat ttcgcgtcca
    80161 tctcactacc tctttcaatc taactctttc cattatatca taaagtaggc aaatccccta
    80221 ttttcaaaaa gtttatcatt tttattttaa tttcttggat gagaaaagag acatatttat
    80281 gaaaaagctc catcgtgctt ttaatgtgtt ctcttgtttt caaactcgta aaaagggagc
    80341 cactgagcct aactcgctct ctcatttcaa agcttgtgaa aaaagacccg ttggggtctt
    80401 aattcgcttt cttgttttca agctcatgaa aaagagaccc aactgggtct tttctttaat
    80461 cttcgtttac gaaaggcatc aaagccatta cgcgagcgcg tttgatagct gttgttactt
    80521 tacgttggtt tttagctgaa gttcctgtta cacgacgagg aaggattttc ccacgttctg
    80581 aaacgaaacg gctaagaagc tcagtatctt tgtaatcaac atattcaatt ttgtttgctg
    80641 cgatgtaatc aactttttta cggcgtttga atccgccacg acgttgttga gccatgtttt
    80701 ttctccttta taagtttagt tgtccattag aatggtaaat catcatctga aatatccaat
    80761 gggtttgttg ctccaaatgg attttcatta cgtgaaaagt ctggtactga atttgtaggt
    80821 gctgaatagt ttgcagttgg tgcagagtaa gctccacctg tgtgaccctc acgcacacta
    80881 cgtctttcca acatttggaa attctcagcc acgacctctg tcacgtagac acgttgtcct
    80941 tgctggttat cgtaactacg agtctggata cgacctgtca ccccgataag tgagcctttt
    81001 ttagcccagt tagcaagatt ttcagcctgt tggcgccaca taacgacatt gataaaatca
    81061 gcctcacgtt caccattttg actcttaaat gtacggttta ctgcaagagt aaaagtcgca
    81121 actgctacat ttgatggggt ataacgcaac tcagcgtcac gtgtcatacg ccctacaagt
    81181 acaacattgt taatcatagt ttaccttctt acgcgtcaat tttgacgatc atgtgacgaa
    81241 gaatgtcagc gttgattttt gaaagacggt caaactcttt aagagctgca tcgtcatttg
    81301 cttcaacgtt aacgatgtgg taaagtcctt cacggaaatc ttggatttcg tatgcaagac
    81361 gacgtttttc ccaagttttt gattcaacaa cagttgcacc gttgtcagtc aaaatagagt
    81421 caaaacgtgc taccaaagcg tttttagctt cttcttcaat gtttggacga atgatataaa
    81481 gaatttcgta tttagccatt gatatgttcc tccttttggt ctaatgaccc caagactttg
    81541 caaggggtaa gtgaggttcg ctcacaataa actattatac tagaaaaatt ttttttacgc
    81601 aagtaaaaac actagaattc gaaaaaacgc cacatgggcg ttttcctgtt cttatggttt
    81661 gatacggtgc aacatacgtg ggaatggaat agcttcacgg atatgttttg ttcctgctgc
    81721 gaaggttacc atacgttcga taccgatacc aaatcctccg tgtggaactg taccgtattt
    81781 acgaaggtca aggtagaatt catattctgt acgatccatg ccaagttcat ccatcttagc
    81841 gacaagggca tcgtaatctt cctcacgcat agacccaccg ataatttctc catagccttc
    81901 tggagcaagc aagtctgcac aaagcacgcg ctctggattt ccaggaactg gtttcatgta
    81961 gaaggccttg atggctgctg gatagttcat gacaaatgtt ggcacaccaa agtggtttga
    82021 aatccaagtt tcgtgtggtg acccaaagtc atcaccatgc tcaagatgct cgtagtcagc
    82081 atcttcatca ttttcatgct cttgcaagag gtcaatggct tgatcgtaag tgatacgttt
    82141 gaatggctct gcaatgtagc gtttcaagag ttctgtatca cgttccaagg tttccaaggc
    82201 ttgaggcgcg cggtcaagaa caccttgtag aagagctttc acataagctt cttgcaagtc
    82261 aagcgactca tcatgtgtca agtatgagta ctcagcatcc atcatccaga attcagtcaa
    82321 gtgacggcgt gtttttgatt tttcagcacg gaaaactgga ccaaagtcaa agacacgacc
    82381 aagagccata gcccctgctt ctaggtaaag ctgacctgat tggctcaagt aggctggcgt
    82441 tccgaagtag tcagtttcaa agagttctgt agaatcttct gccgcatttc ctgaaagaat
    82501 tgggctgtca aacttcataa aaccgttctt gtcaaagaac tcataagttg catagataat
    82561 agcgttacgg atttgcaaca cagctacttg cttacgagag cgtagccaca agtgacggtt
    82621 atccatcaaa aagtctgttc cgtgttcttt tggtgtgatt gggtagtctt gagattcacc
    82681 gatcacttcg atgtctgtga tgtccaactc atagccaaat ttagaacgtt cgtcctcttt
    82741 gacaatacct gtcacataaa cagacgtttc ttggctcaag cgtttgataa catcaaactt
    82801 ctcaagtccc acttcttcac caaatttttc gacaaagttt ggtttaaaag ccacaccttg
    82861 aaagaaggct gttccatcac gcaattgtaa gaaagcgatt tttccttttc ctgatttgtt
    82921 ggcaacccaa gcgccaatcg tcacttcctg accaacatag tcttttacgt caataatcgt
    82981 tacacgtttt gtcattattt ttccttttct tttttattct ttatggcaaa ccacctctat
    83041 attgttccca tccaggtcaa tcataaaagc agcatagtaa atcggatgct cacttcgata
    83101 accaggagcc ccattgtctc gcccacctgc ctctaagcca gcctcataac aagcctgaac
    83161 ttcttcctta ttttctgcta aaaaagcaaa atgaacagga tcttgtgttc cctgagtcag
    83221 ccaaaaatca ccaccaggat gagggctgtt cggggataga aaactaatta gagaactagt
    83281 cttaaaagcc aatttatagt ccaaaggagc gagaaaactc ctataaaatc cttctgaaat
    83341 ttgtaaatcc tttaccttaa tctcaaaatg atcaatcatt ctcactaccc ataaatgctt
    83401 tcaagcgttc gactgcttct ttaagcgtgt ctaggtctgt cgcatagctg aggcggacat
    83461 tttctggtgc tccaaatcca gctcctgtta ccaaggccac ttcggcttct tctaagatag
    83521 cagttgtaaa gtctgtcaca tccgtgtagc ctttcatctc catggccttt ttgacatttg
    83581 ggaagagata gaaggcccct tgcggtttga ccacttcaaa tcctggcacc tctgcaagga
    83641 ggggatagat ggtattaaga cgttcctcaa aggcctgacg catgctttct acagtatctt
    83701 gctcacctga tagagcctca actgctgcat attgggctac tgctgacgga ttcgaagttg
    83761 tttgacctgc aatcttggac atggcagcga taatgtctgc ttctccaacg gcataaccaa
    83821 tccgccaacc agtcatggca taggttttag aaacaccatt gatgaccact gtttgcttgc
    83881 gaatcgcttc cgataggcta gaaatcggtg tgaactcatg accattataa accaagcggc
    83941 catagatatc atctgctagg atgagaatat cattttctac agcccagttt ccaattgcca
    84001 agagttcctc acgggtgtaa atcatacctg tgggattaga tggcgaattc agcaccaaaa
    84061 ccttggtctt gtcagtgcga gctgcttcta actgatctac ggtcacctta aagtgattgt
    84121 cttccttagt agaaacaaag acgggaacgc cttctgccat cttgacctga tctccatagc
    84181 taacccagta tggggttggg atgatgactt catcacctgg attgaccgca gccataaaga
    84241 aggtatagag agaatatttg gctcccgcag cgactgtcac ttgatttgac gctacagaat
    84301 agccgtaaaa gcgctcaaag tagctattga ccgccgcctt aagctctggc agacctgagg
    84361 ttactgtata aaaagaagca cgcccatctc gaatcgatgc aatggcggca tcttggatat
    84421 ttttgggagt agtgaaatct ggctcaccca aggttagaga caaaatatct ctgccctcag
    84481 ccttcagtgc tttggcacgg gctccagcag ccaaagtcac actttcttcc atttctaaaa
    84541 cacggttgga taatttcata ggccctcctt gttgaccaat gctcctgttt caaaatctac
    84601 tagataaaaa tcagatcctg acttgacttc ccagattggc ttatcttgat aacgaccaaa
    84661 gataatcttg tcaatttcgc cagctccctt ttccttagaa accgtttctg ctttttcttg
    84721 tgaaacaccc tgatttagct gataaacgta aatcttatga tcatcttttc caatcagaac
    84781 agcaagtgct tcttgctgtt tattacgacc aagaacgctg taataagatt ccaagccatt
    84841 gtataaatca acctgatcgg cctgctctaa tcctgcatac tgctgagcta atttttctcc
    84901 ttcactttta gctgtttgat agggtttcat gctaagagaa accatataca gaaaggaagc
    84961 actgataacc acaaacaaaa tcgtcatccc tagaccatac tgccacagta gattattttt
    85021 tgctttgttt tgtctttttt tcactcgtct attttaccat ctattaagct ttattacaag
    85081 tgaatataag aatactcttc gaaaatctct tcaaaccacg tcagctttat ctgcaacctc
    85141 aaagctgtgc tttgagcaac caattctatt tctcccttca aacaaaaccg attttgaaag
    85201 tgaaacagtt cttacttttt cagtcacaaa tgactagagt ttccgaaatt ttacaatttt
    85261 caaataaact ctgagcaaat ttcttgcaag ttcttttgtt ttgttgtaat atattttata
    85321 acaacgagag agttctcgaa attttaagaa aaaggagaca catcatgtct aaaaaagtat
    85381 tatttatcgt cggatcacta cgtcaaggtt ctttcaacca ccaaatggcg ctcgaagctg
    85441 agaaagcact tgctggtaaa gcggaagtta gctaccttga ttattcagcc cttcctctct
    85501 tcagccaaga tttggaagtt ccaacacatc cagctgtagc tgctgctcgt gaagcagttc
    85561 tcgttgcgga tgctatctgg attttctctc cagtctacaa cttctctatc cctggtacag
    85621 tgaaaaactt gcttgactgg ctatctcgtg cccttgactt gtctgataca cgtggcgttt
    85681 ctgcccttca agacaagttt gtcacagtat catctgtagc caatgcaggg cacgatcaac
    85741 ttttcgctat ctacaaagac ctcttgccat ttatccgtac acaaggcgtt ggtgatttca
    85801 ctgctgcacg tgttaatgac tctgcctggg cagacggaaa attggttctt gaagaaacag
    85861 tcctaaactc acttgaaaaa caagctcaag acttggtcga agctatcaag taactaacac
    85921 tcaataaaaa tcaaaaagca aactaggaag ctagccgcaa gctgctcaaa acactgcttt
    85981 gaggttgtag atagaactga cgaagtcagt gacatatata cggtaaggcg acgctgacgt
    86041 ggcttgaaga gattttcgaa gagtataaca taataaaagc gaacaagact acttttctga
    86101 cactcagaag actagcttgt tcgctttttt tctcatttat aaactaaaac agctgatgat
    86161 acatattgcc aaatacaaaa tatctgattt ctatacttcc tttacaaaaa ccaatccctg
    86221 tggttgtgac aaatcttctc ggtaaacaaa tccagcaaag ttcaagcgac gtgcttcccc
    86281 cacagtttgt acttgatttt ctattaaagc tgttagaaag gccccgcgcg ctttcttgga
    86341 gatagttgag tgaatcttca gctgaccgcc tctatcctcc atgaatttga aggtcaccat
    86401 ctttgctctg atttccttag aaaatacagt ctcaaactct gatgacaaga gagagaaaat
    86461 cacttcttcc ttcttcagag cttcatcata gactgccttc caatggctct tcaaagtctt
    86521 accagcgact tttaatttca tcaaaaaatc caaacggtga ggagccatgg gtgacaaggc
    86581 tggaacaaca ccgtacaaag ccgaggtaat gaagacatga ttttcaagat aatcttgttc
    86641 cgcctcggtc agcttatctc tcttaatgtt gcggtacata agcccatcaa aaagtttcaa
    86701 ggctggatag tgttgagcag tttgcctttt caaagcttgg atattttgaa attcttccgt
    86761 cgctttctca gctgatacct tgtagaaact ctccaattga ctggcagaat agagagccaa
    86821 ggcatcaagc acggcctgac tttctggttt taaaggagtt gcctcgatac ttggcaagtc
    86881 tgtgttcatt tcttttgctg ttgggattaa aattttcata ttgatagtgt agcatatttt
    86941 ttagccacaa ccaagaaatt catttgaaaa acctcggttt gactgaggtt tttctattta
    87001 tttgggccat cctaaccaga cagccgcgag aacaagggct atgccagcta aacttgttaa
    87061 gatagataag aatttatctt ttttctcctt gaactgagaa aaacctatct tcaaagcgag
    87121 cagtccgagt agcattgaag caaccatcaa ataaaaaccc atttctttgt cctccattag
    87181 gcttaattta ccttattata acatatattt attaaataaa ccttttttat actcaatgaa
    87241 aatcaaagag caaactagga aactagccgc aggctgctca aaacactgtt ttgaggttgc
    87301 agatagagct agagattttc gaagagtatt attgtacttt aaaggtcttg agataattgt
    87361 cttttcctac ttgaccttcg aaggttttac cattttcaag gtaaggaagg tcatcggata
    87421 ctgaagcctt gaccttgtat atcttgccat caactttaaa gaagtagaca gtgtctccct
    87481 tgataacagc tgatttgagg tctgctacta ctccattgat gctttctgtc gttgcattgt
    87541 caatttcaag gtcgttttta ttggcatact tgctgagcat ctcttccact gtagtagcaa
    87601 cgataacatt ttggtactcg actgcgtcta ccagggcgta ctctttgacc aagccagcat
    87661 tgtccttcaa gcccatgatg tagagaggct tgtcattgag gttgatgagg attgggaagg
    87721 ttgctttgta ggatttctcc tgaacagcac cttctgctga ttcacgggct gattcttctg
    87781 tcgcagaagc caagctatac ttagtgattt ctcctgttcg catattttca aggatgaaac
    87841 caagattact ctcatccgca ttagccgacg tcacacctgt gtagagatag atgtcattac
    87901 cgatagacaa gtaattatag cccttggtag tctgggtcac gtttttcttg gaaatcatgg
    87961 cattcaagaa accgtccttg tacttgccgt tgtagttgat ttgctcaatg gtttcctctg
    88021 ctggatagat cctgtccacc cattctggaa catctgataa gctgtattcc ttggtttctc
    88081 catttgtagc atccaagata atgactgaag caggacgagg aacagcaagt ccaaattgct
    88141 tttggtaaac cgttgctaca tagaaaggat tgccctcatc gtccacctca aaagatggag
    88201 ttttaaagat tttggtcggg tacttcaagc gcaggtgacg tttgacatca cggttaaaat
    88261 actccgagtc tgaatacttg attggtgtct tcaagtccac caaatccgca tttccagtta
    88321 ccatgtccac cttgatatac tcaccgattc ccttggcttg attgttaaac catttgatag
    88381 ggtctgcata ttctagtggt gtgacccgat aaggtttccc atcaattgtc aattgggtat
    88441 aggtatctgc cgctacgtat tgcgacacct tatcggttag ggaacccaag tagcggtctc
    88501 caattttttc agcagtactt ctatctagga taggaacctt actggtgtca ctcctaggaa
    88561 attcagtaaa gtctttttcc gtaaccgtga ctacattggc ataattttta gcctgaaaca
    88621 tgctggaagt taccaaggaa accaaagctg ccaagagaag aattcctcca atcgaagcta
    88681 acagaatttt ccctaaccga ttgattttga aaccctcaag atttaaggca gcttccgcct
    88741 taccgtggcg cacatgaacc gttttgacaa ggtttatccc cttgccaaag ccaaataaga
    88801 ttgccacaac taacaaatgc ccacagagga agaagagaaa ttcccagctg gtcaggttaa
    88861 ggggcggtaa aaagatatac caggtcgttg cgataaaaat aagttcaaag actattcgtt
    88921 tcatttgctt tcctcctaaa tgattcgtcc ttccaagtga tccagctcat gctggcaaat
    88981 ctgagctggg aagcctgtca aggtaatggt ctgttcctgc cacttgctgt cacgataggc
    89041 aacccttatg gtttcataac gcttagttga tctcacgcct accaaggaca aacagccttc
    89101 ttctgcctca taggatcctt caaaggacag aagcactggg ttaaacatga ccacgggaac
    89161 caagccaaga ttaaagataa tcacgcgctt ctgcacccca atcatattgg cagctagacc
    89221 aacacaggta tcatgatttg ctaagagtgt atcctgcaaa tctctggcaa gataaaggtc
    89281 ctcctgactt gccggctgag acacttgaga taaaaataag atatccttca caattttctt
    89341 ttccacttcc tcacactcct cttgcttttt actatattat agcaattata gcacaaaagc
    89401 cgataactgc aaaccctttc cctcaactgt agcaaaaagc catccgaaga tgactttttt
    89461 gctatttaat ttctgtataa gttacttcca agccacgctt aacagctgga cgattggcaa
    89521 ttttttctgc ccattttact agattttgat aacttgaggc atccaagaat tttgcagaac
    89581 cttggtaaag atttccttga actaactgtc cataccaaga ccagatagca atatctgcaa
    89641 tcgtatagtc attgcctgca atataaggtt tctgagccaa ttccttatcc aataaatcca
    89701 actggcgttt cacttccatt gtaaaacggt taataggata ttccaatttt tcaggagcat
    89761 aattgaagaa atgtccaaat cccccaccta gaaaaggtgc tgcacctgct tgccagaata
    89821 gccaattcaa aacttctacc ttttccacag gattacttgg taaaaaggct ccaaatttct
    89881 cagcaaggta aagaagaata tgagcagact caaagactct tacatcttca gtacctgact
    89941 ggtccaataa ggctggaatc ttggaatttg gattgagctt cacaaagtct gatccgaatt
    90001 gatccccatc catgatagca atcttataca agtcgtaagc cgcttcctta aaaccagctt
    90061 ctagtaattc ttccaataag atagtaacct tcacaccatt tggtgttccc agtgaataaa
    90121 gctgaaaagc ttgttctcct tttggcaagt tttgttcgaa acgggcacct actgttggtc
    90181 tgtttagccc cgtaaaagct ccttgattac tagcttcatc ctgccatacg gtcggtaatt
    90241 gatatgctga catccgaaac ctcccttaaa tcgcattctt gtcaaaaccg agtttgcgtt
    90301 gaataaactt aacgatttcg acgatgataa tcattgagaa gcttccagcc ataacaattc
    90361 cccattgtga caagtctagt ttggttacgt ggaagattcc ttcaagcggt tctacaacga
    90421 ttgttgccat gagaaggata aaggatacca agatggacca gttaaaggtc ttagacttga
    90481 atgggccaac tgtcaagatg gattggtaga cagacttgac attgtaggca tggaagagct
    90541 gaatcaaacc aagggttgca aaggccatcg ttagggcatc tgcatgaata gcatgattgt
    90601 cacccacatg aactgggtaa gcaatcgcaa ggccataaac actcataaca agagctgctt
    90661 ggagtacacc ttgataaatg atagaactca aaacaccacc tgagaagaag cttgccttgc
    90721 gtccacgtgg tttatgattc atgacaccag gttccgcagg ttcaacacct agtgcaattg
    90781 ctgggaaggt atccgttacc aagttaatcc acaaaagatg aactggctgc aagacgtccc
    90841 aaccaaacaa ggttgatagg aagatggtta atacttcagc agtattggca gaaagtaggt
    90901 actgaatagt cttttgaata tttgagaaga ccttacgtcc ttcttccact gcgacgataa
    90961 tagtcgcaaa gttatcatct gcaagaatca tatcagaagc ccccttagaa acctctgtac
    91021 cagtgattcc cataccgata ccgatgtctg ctgttttcag agctggggca tcattgacac
    91081 cgtcacctgt catggcaacg accttacctt gtttttgcca agccttgacg atacgaacct
    91141 tgtgctctgg agacacacgg gcataaacag agtattgacc aacaactttt tcaaagtctt
    91201 catcagataa ttcgttgagc tcagcaccag ttaaaacgtg gtcttctgta tcgtttgcgt
    91261 caatgattcc caaacgtttg gcaatagctt ctgcggtgtc ttggtggtca cctgtaatca
    91321 taattggacg aattccagct tccttagcca cacgaacagc ctcagcagct tcaggacgtt
    91381 caggatcaat catcccaatc aaaccagtaa aaattaaatc attttcaagc tcttcagaag
    91441 tgagattttc tggaatacta tcgataatct tataagcacc tgcaaggaca cgcaaggctt
    91501 gatgagccat ttcagaattg tttgtatgaa tgagatttgt aaccttctca tcaatcggag
    91561 caatatcccc agccttatca cgaagaagac aacgttttaa gagttggtct ggcgcaccct
    91621 tgactgctac aaggaaacga ccatctggca atgggtgaac tgttgacatg agcttacggt
    91681 cagagtcaaa tggcaattca gctacacgag gatatttctc taagaaacct ttgacatcat
    91741 agcccttgtc caaggcatat tggataaagg ctgtttcggt tgggtcacca atcaagttac
    91801 cttccacatc gattttcgta tcattggcca agacaactga acgaagtagt ggcatttcaa
    91861 gacctagttc aatatcatca gctgagtcat gtagaaccgc atcgtagaag actttttcga
    91921 ctgtcatctt gttcatagtc agcgtaccag tcttatcaga agcgatgatt tcagttgaac
    91981 caagtgtttc aactgctggc aacttacgaa cgatggaatg tcgtttggcc aaaacttgag
    92041 taccaagaga aagaacgatg gtaacgatag caggaagtcc ttctggaatg gctgcaacag
    92101 caagggcaac agaagtcaac aactcaccaa gtggattttt cccttgaatg aagacaccca
    92161 ctacaaaagt aacaagggca atgaccaaga tagcataggt caagacctta gaaaggttgt
    92221 tcaagttttg tttgagtggt gtatcagtct catccgcatc ttgaagcata ccagcaatat
    92281 gaccaacttc agtgtacata cctgtattga caacaacacc catcccacga ccataggtta
    92341 cgtttgagtt ttggaaggcc atgttgacac ggtcaccaat accagcatct gtcgcaagct
    92401 cgactgacaa gtctttttcg actggtacag attcacccgt caaggctgct tcttcaattt
    92461 taagagagtt ggcttctagc aaacgtaggt ccgctggtac cacgtcacct gcttcaaggg
    92521 caacgatatc gcctggtacc aattctttag agtcaatctc tgccatgtgt ccatcacgaa
    92581 gaacgcgggc aactggacta gacatggatt tgagggcttc aatagcttct tcagcttttc
    92641 cttcttggta aacaccaaag gcagcgttga tgataaccac agctaggatg ataatggcat
    92701 ctgcgatatc ttccccacca gaagtcacga ctgacaagat tgctgccgca actaggatga
    92761 taatcatcaa atccttaaat tgctcgatga atttgaccaa gattgatcgt ttctcgcctt
    92821 cttcgagttc attgtgccca aattcggcaa ggcgcttttc cgcctcactt gatgacaaac
    92881 cttgctcggt cgcatccaca gcctgcaaga cctcttcagg gctctgagta taaaacgctt
    92941 ggcgtttttg ttcttttgac atgtgtctcc tccttgacat tgtgtgcaaa acagactctc
    93001 tttctgtcat atcttttcac gacaaacaaa aagagacctg ttaatcataa caagtctcgc
    93061 tgtttaagat agggccggaa agcatacttt tcagcataaa attcggaatg acgacactat
    93121 cacaggtttc tgccagctac tcccttgagt agtaccatta taccaaattt tggggagttt
    93181 tcaaagagta aaaactgcct tatttgaatt tttccttgaa aaccagtata atggtagaat
    93241 gctatgtgac tagaaaggaa gttgaatgaa gcaatctatc tcaaatctca agttagctga
    93301 gcgtggagcc attatcagta tttcgaccta tttgatcttg tctgcagcca aattagcagc
    93361 tggtcatctc cttcattcat ccagtttggt ggccgatggt tttaataacg tatcggacat
    93421 cattggaaat gtggccctct taatcgggat tcggatggcg cgccagcctg cagaccgtga
    93481 ccaccgtttt ggtcattgga agattgaaga tttggcaagc ttgatcactt ctatcatcat
    93541 gttctatgtc ggtttcgatg ttctaagaga taccattcaa aagattctca gtcgggaaga
    93601 aacggtcatt gatcctcttg gtgcaactct aggaatcatt tctgcagcga ttatgtttgt
    93661 ggtctatctc tacaatactc gcctcagtaa gaaatccaac tccaaggcgc tgaaggcagc
    93721 tgctaaggac aatctttctg acgctgttac ctcacttgga accgccattg ccatcctagc
    93781 tagtagtttc aattatccga ttgtggataa actggttgct atcatcatca ctttctttat
    93841 cttgaagact gcctatgata tcttcatcga gtcttccttt agtctttcag atggctttga
    93901 cgaccgcctg ctcgaggact accaaaaggc tatcatggaa attcccaaaa tcagcaaggt
    93961 caaatcgcaa agaggtcgca cctacggtag caacatctac ctggatatta cactagagat
    94021 gaatcctgac ttgtctgttt ttgaaagcca tgaaatcgcg gatcaggtcg agtctatgct
    94081 ggaggagcgt tttggcgtct ttgataccga tgtccatatc gaaccagcac ctatccctga
    94141 ggatgaaatt ttagacaatg tctataaaaa attgcttatg cgtgaacaat tgattgacca
    94201 aggaaaccaa ctagaagaac tcttgactga tgattttgtc tatattcgcc aagatggaga
    94261 gcagatggat aaagaggctt ataagaccaa aaaagagtta aattctgcta tcaaggacat
    94321 tcaaattact tccatcagtc aaaaaaccaa actcatctgc tatgagttag atggtatcat
    94381 ccataccagt atctggcgtc gccacgaaac ctggcaaaat atctttcatc aagaaaccaa
    94441 aaaagaatag agaaatcctt tcatgagacg ggatttttct attcttttat actcaataaa
    94501 aatcaaagtg caaattagga agccggtcac aggctgtact tgagtcggca atgtgaagcc
    94561 gacatagttt gcactttgat tttcgaatag tcttaactat caaattcact gagatactca
    94621 tagcgttcgt atttttcaag gagtgcttca tttttctcat ccaattcttt ttggagagta
    94681 gccagcttac caaagtcaga gccgttagcc tgcatttcct cttcaatagc agcgatacgt
    94741 ttttccaagg tttcaatatc accttcaata cttgcccact cctgcttttc ttggtaggtc
    94801 atgcgtttct tgtcttctcg aaccttgacc actttttcct tttcggcctt ttgcacttga
    94861 ttggccatat ctgtttcaaa agctttttca tcaagatagt cggtgtaatg accaaagaaa
    94921 ggacgaatct tgccatcctc aaaagcgaga atcttggtcg ctaccttatc caagaaatag
    94981 cggtcgtgac tgactgttaa aacgggacct gcaaaacctt gcaagaaatt ctccaagact
    95041 gtcaaagttg caatatctag gtcattggtt ggctcgtcta aaagaagaac atttggtttt
    95101 tccaaaagca gtttgaggag ataaagacgt tttttctcac cccctgacaa tttctcaatc
    95161 aaggttccat gcgtcgaacg tgggaaaagg aactgctcca gcaactctgc aatcgaagtc
    95221 gtagaaccac cactggtctt gacctcctct gccacttcct gcaggtaatt gataactctc
    95281 ttgctttcat ccaagccctc aatttgctga gagaaatagg cgatgcgaac agtttcccca
    95341 atcacaactt gtcctttagt tgactcaaga cttcctgcaa ttaagttgag taaggttgat
    95401 tttccaacac cgttgtcccc aacgattccg atacgatctt tgacctgtac caagagatta
    95461 aaatcttgca aaatgggctt gttttcatag gcaaaggaaa catcctgaaa ctcgatgact
    95521 ttcttcccaa tccgactggt ttcaaagttc atagtcaagt ctgtctcagc actactgcct
    95581 gaaacttcct ttttcagatc atggaaacga ttgatacgag cttgttgctt ggtcgcacgt
    95641 gcctgcggtt gtctgcgcat ccaggccagt tcttgtttgt agagttgttc ttttttatga
    95701 agtagagctg catcgcgctc gtcctgttct gccttaaggc gaacatagtc ctggtaattg
    95761 ccctgatatt ctgtcaagcc tgctcgctcc aactcgaaaa tccgtgttga caaagcgtct
    95821 aagaaataac gatcgtgagt gataaaaagg acggtcttct tagaattttt caaaaagagg
    95881 gtcagccact caataatcgc aatatccaga tggttggtcg gctcatccaa aagcaaaagg
    95941 tcgtggttgc caagtaagac ttgtgccaac tgtacccgtc ttctcagacc acctgacaat
    96001 tccccaacag gagtagataa gtcttgaatg cccaatttgc taagaacggt cttgacctga
    96061 ctctcgattt cccaagcttg gagagagtcc atctctgcca tgacacgttc caaacgcgcc
    96121 tgcttgtcct cactatagtc gagcataatc aattcatact cacgaatgag ctggatttcc
    96181 ttgagttcac tagatagaac cgtatccaaa actgtctttc tatcatcaaa atcaggatcc
    96241 tgagtcaagt aaccaatctg gtaatcattt ttagctgaaa aaggactgac atccccatca
    96301 aatccagaaa caccagaaag gacgtccaaa agggtggtct tgccagtccc attgacaccg
    96361 attaaaccaa ttctgtctaa gtcatggata ataaaggaaa tatccctaaa aacggtcttg
    96421 tcaccaacgg atttacttag tttttcaacg ataaaatcac tcattttttc tccctcaggt
    96481 aagcatggat ggcttcacga ttattctcca attctccatc gacaatggca aactcaatct
    96541 ctgttaaaat ctctcccaag tctgggcctg gctgatagcc atattccttg atcaaaatat
    96601 cgccattaat ctgaatctct ttcttgtcat ggatagtcaa gctttggtat ttttctgtga
    96661 tggcttgtag gttgacttct tttccttgag cttgacgaag attttcagcc tgtaaaagca
    96721 aatctatatc aaagcgataa caatctcgct tgctcaattc tccattttca cgcagagcca
    96781 aaataatcag caaatcctga acttgcttgg caaactggcg tgaggtcttc caagatttca
    96841 aaaatgactg cgcattttca atctccaaag cccatagtaa agccgcccag gcttgttcag
    96901 aggattcaaa agtaaaatca gtctccaaat caaacagtct gttgagcttg tcctggctag
    96961 atgccatatc agggagatag tcataagctt gactctcaat catggaagcc aagccccttc
    97021 tccaaaatgg agccagcaag agtttatcaa actcgacgaa ggtacgctct acagaaattt
    97081 tctccaaaag cggcgtcaag gtcttcatag ctttaaatgt ttctggctca agtgcaaaac
    97141 caagactagc ctgaaaacgg aaaccacgca taatccgtaa agcatcttcg ttgaaacgct
    97201 cactagccac tccaactgct cgcaagactt gcttttccaa atcttctaaa ccatggaaca
    97261 agtcaacgat ttctcctgtc tcatccaagg caaaggcgtt gactgtgaaa tcacggcgtt
    97321 tgaggtcttc ttctagcgag cgcacaaagg aaaccgcact gggtctgcga tagtccacat
    97381 agacatcctc tgtccgaaag gttgttacct catactcctc atccccatct aagaccaaga
    97441 cggttccatg ctcgattccg atatcggctg ttcgcggaaa aatctgcttg gtctcttctg
    97501 gataagaaga cgtcgcaata tccacatcgt ggatagggct atggagaagg gcatctcgaa
    97561 cagagccccc aacaaaataa gcctcaaagc ctgcttcttt aattttttct aatactggta
    97621 aagccttctg aaattcagaa ggcatttgcg ttaatctcat aataagtgtt ctaatccata
    97681 gacaagctca tgacgcttga caacttcttt aattcccaaa ttgactcctg tcatgaagga
    97741 gatgcgatca taggagtcat gacggagggt caacccttct ccctgattgc caaagatgac
    97801 ttcctgatga gctaccaagc ctggcaaacg aactgagtgg atgcgcatac catcaaagtc
    97861 agcaccacga gcaccagcaa tcagctcttc ctcatctgct gcaccttgct gaattgactc
    97921 tcgaacctct gccatcaact cagctgtttt aatggctgtt ccactcggag catccttttt
    97981 cttgtcatga tggagctcaa taatctccac atttgggaaa tatttggcag cctgcgtcgc
    98041 aaattgcatg agtaagacag cacccaaggc aaagttaggg gcaatcaggc cacccaagtc
    98101 ttgggcacga gaaaattctt ttagctctgc aatttcttca ctcgtgaaac cagtcgttcc
    98161 aactactgga gcaaagccat tttcaagagc aaaacgtgta ttttcgtagg caacagctgg
    98221 agtagtaaaa tctatccaga catccgcttc aaaaccagct aaatcagcct tatccttgaa
    98281 aacaggaata ccctgccatt ctgactcaga ctcaaaagga tccaaaactg ctaccaagtc
    98341 caagtctgga tcagtcaata ccatctgaca agcagcctgg cccatctttc ccttaaaacc
    98401 ggcaataatt actcgaatac tcatctctac tcctgtccaa gatacaaagc ctgtaagaac
    98461 acaaagtgaa aataggaatt ctgatcaaga agtgtctact tcttggaaga actatctttt
    98521 tcacacaggg ttccaggcgt gttcaattat caagatacaa aggaccttag ctgcccctga
    98581 aaaataggga atggcactga ctttccacga aaggcaagac aggcatcttt tttcaagagg
    98641 caggtagtcc gtgttcaatt tctaagatta actagcctag aagtgccaac taaatcactg
    98701 gaatataacc tagagcaata cttcctgctc ctaggtgcgt tccaatgaca ctaccaaatg
    98761 tagcaagtga aacatccgaa cccaagccaa aatcaagcaa atgctgacgc aattcttcag
    98821 ccttttcagg agcattccca tgaatgacaa tgacccggta ttgacctgaa gccgttgttt
    98881 ccttgataat ttcaattaag cgtttggtgg ccttcttttc agtacgaact ttttcgtaaa
    98941 cttcaatcac accttgatcg ttaaaataaa ggattggctt aatgctaagc aaattgccca
    99001 aaatggcagc cccatttgaa aggcgtccac cttttaccaa atgatccaag tcatctacca
    99061 tgataaaggc tgacgtacgg ctgatttgaa tggctagctt atcctgaatg ctggcaaaat
    99121 catcgccctg atcacgccaa ttaaagacgc tttcaaccat gatgcctagg ggagcacttg
    99181 taatcaaagt gtctgggaaa gcaatggtta agccctcata gtcatcgacc atatactgga
    99241 tattttggta aaaacctgaa attccagaag ataggaaaag ccccaaggca tgtgtataac
    99301 cttgttcttt gagcgaagtt aagatttcat ctaacttggc aatacttggt tgactggtct
    99361 taggcaattc agaagcctga gccatttttt ggtaaaattc ctcagcagac agattgatgc
    99421 cttcgacata ttcctcacca tcaatattga caggaatatc caagacaaac aagtcttctc
    99481 tttgcaagat ctctgcactg agataagcag aggaatctgt gaaaacagct aatttcatat
    99541 tagaactcca aattaattcc tggtaagtct aatgcaattt cagtcacttc gtaagtcaaa
    99601 cgattgagca tgttcaaaca tggacgagcc aaggtttcca cctcttcttg gttcaattca
    99661 cttggttcat tgacaatacg gccatcgata tggtttactt gtgagattgt tccactaatg
    99721 acaaacttat caaatacaat cataaagctc aagatgacaa tcaaggaagt cacttgattt
    99781 tcttggtcat gttggagcaa ttggaaattc acatccacct tggtttcagg agctccattt
    99841 tcattttccc attcaaaatt acgtgcatca aaatgatact gactaacaaa ttcttgttca
    99901 cgtttaagat tcatgtcttt ctccatcggc tacaatatta taagctattg taccataatt
    99961 ttttattttc atctagtttt ctaggattta gtcaatccca atttcagcac gaactacatc
   100021 tgtgatagta tcaacatagt agtccacttc ttctgttgta ggcgcttctg ccataacacg
   100081 caagaggggc tctgttccac ttggacgaac aaggatacgg ccgttccccg ccatttcttc
   100141 ttccatcttc tcgatgatgg ccttgatagc tggcacttcc atggcctttt ccttcatgac
   100201 gttttccact cggatattaa ctaatttttg tggataaatc gttacttctg ccgccaactc
   100261 tgataagctc ttaccagttt ccttcatgat tttagtcaat tgaactgctg ataattgacc
   100321 atcacctgtg gtattgtaat ccatcaagat aacgtgacca gactgttcac caccaaggtt
   100381 gtaacctgat tttctcattt cttcaacaac gtagcggtca ccaactgcag taactgcctt
   100441 gttaatacct tcgcgattca aggccttgtg gaaaccaagg ttagacataa cagttgtcac
   100501 aattgtattt tgagccaatt gtcctttttc agaaaggtat tttccgatga tgtacataat
   100561 cttgtcacca tcgacgatgt caccattctc atcaacagca atcaagcggt cactgtctcc
   100621 atcaaaggcc aaaccaataa ctgacccact ttctttgacc acttcttgaa gggcttctgg
   100681 atgtgttgaa ccaacattaa ggttgatgtt aagaccgtct ggtgtttccc cgataaccgt
   100741 caattgggca ccaaggtctg caaagatttg acgggcactg gtagaagctg ctccattagc
   100801 tgtatccaag gcaaccttca ttccatcaag aggagttcca gttgaaacaa ggtatccttc
   100861 atacttacgc aagccttctg gataatctac caaaattcct aagccttctg cacttggacg
   100921 aggaagagtg tcttcctcag catctagcaa ggcttcaatt tctgcttctt tttcatcatc
   100981 tagtttgaag ccatcaccgc caaagaactt gattccgtta tcaagggctg ggttgtggct
   101041 agcagaaatc atgacaccgg cacttgctcc ttcagtttca accaagtaag ctactgctgg
   101101 tgttgcaagg acaccaagtt tgtatacgtg aatccctact gaaaggagac ctgccaccaa
   101161 ggccgattcc agcatttccc ctgaaatacg tgtgtcacgt cctacaaaga ctttcggcgc
   101221 ttccgtttca tgttgactaa gaacatagcc tccaaaacgt cctagtttaa aggctaattc
   101281 tggtgttagt tctaggttag cttctccacg gactccatca gtcccaaaat atttacccat
   101341 tgttataaaa tccttttcta tttttaattc gtttttgaac tagttgcttt cgttgacgaa
   101401 gatgtctccg atgaactgct tgtacttgaa tttgatgtgc ttgaacttgg tgctactggt
   101461 tttgtagtca ccttcattat tgtatcaaac ggagtgataa ctgccggtaa gacaacacca
   101521 ttgcggtcga ttgcctgcaa aggtactgaa ccactgtaat tacctgttat gcgttcgcta
   101581 gttggcaaga cagcgataat cttatcaatt ctatccaatg tctcttggtc actcgtaata
   101641 gacgcttctt tatctgacac catgacattt tcaatttgta cccgactatc aatttgacta
   101701 gggtcaatct ctggtacaat ctttacctta tccttctgag ccttcttacc aatcttgact
   101761 gtaatttttt gcggagtcgc cacagcggtc agcccattgg gtaaatcttc aatgctcaaa
   101821 ggaacttcaa ttgttccaac accggcatct gttaggtcag cagtaacctt gaatttacgt
   101881 gtactttctt gcatttcact agctagcgat aggcgatttg caccagtcaa gaccactgat
   101941 acttctgaag caaaaccgct aataaaatac ttatcactat tatagcgtat gtcaataggg
   102001 acatttgtta ctgtattagt ataggtttcc gtttttacct gcctagcact ggtactgttt
   102061 tgaaaattcg tcgccgtagc atagacaaat aagacacaag caaaaaagag tgaggatatg
   102121 atatataaac tatttttttt catgtttcca tcctcctagc aatcgttctt taaaactaag
   102181 acccacttcc tcttttggaa gtaagatttc acgtaattct gtttcaaatt catcaagtgt
   102241 taggttgtgc ttaaaccttc cattataggt tatcgaaatt cctcccgttt cctctgatac
   102301 gacaaaagtc aaagcatctg agacttctga taaaccgata gccgcccggt gtctggtccc
   102361 aaattccttg gaaatccctg tgttttttgt caagggcaga taggcagacg tcacagcgat
   102421 acgttcttct ttgatgatca ccgcaccatc atgtagggga gtgttgggaa taaaaatgtt
   102481 aatgagaagt tctgcagaaa tcttagcatc caagggaatt cctgtcgaaa tatactcctg
   102541 caaggtacgt acacgctgaa tagcaaccaa ggccccgatt ttacgaggac tcatgtattc
   102601 aacagactta acaaaggcac gaatcatctg ttcctcagca ctaatagggg cattggaaaa
   102661 aaaatctgta gctcttccca aacgttccaa accagtccga atctctggag agaagataac
   102721 aaccgccgca ataaccccat aagtaataat ttgattgatt aaccaagaaa tcgtagtcaa
   102781 accaatcata tttgcaagga tttgagctaa aataaacacc aaaactccac gtaccaaaat
   102841 cataatcttg gttcctgcaa tagcttttgt aaaatggtat aaaatataag caacaatcaa
   102901 aatatcaatc agattgatag ctatcgtcca tggacttgca aacaaactgg tccaatattg
   102961 cagattggat aattgttgaa aattcatccc tgatatcctc cctatcaaaa cactttcgtc
   103021 ctattatacc attttctggc atttttttcc ctatcctagt ccattttaca ttgaacaaaa
   103081 atatgataaa ataaactgac tagaaaaaac aaaggagaaa ctatgtctca actctatgat
   103141 attaccattg tgggtggtgg tcctgtcggg ctttttgcag ccttttatgc ccacctacgc
   103201 caagccaagg ttcaaatcat cgactctctt ccccagctag gtggacaacc tgctattctc
   103261 taccctgaaa aggaaatcct agacgtacca ggcttcccaa acctgactgg agaagagttg
   103321 actaaccgct tgattgaaca gctaaatgga tttgataccc ctattcatct caatgaaacg
   103381 gttcttgaga ttgacaaaca agaagaagaa tttgccatca caacttctaa aggaagtcac
   103441 ctgactaaaa cagtcatcat cgctatgggt ggcggtgcct tcaaaccacg tccgctggaa
   103501 cttgaaggtg ttgagggcta tgaaaatatc cactaccacg tttctaacat tcagcaatac
   103561 gctggtaaga aagtgacgat tcttggtggg ggagactcgg ctgtggattg ggctttggct
   103621 tttgaaaaaa tcgcaccaac tacccttgtt caccgcagag ataatttccg tgccttggaa
   103681 cacagtgttc aagccttgca agaatcatct gtaaccatca agacaccatt cgcccctagc
   103741 caactccttg gaaatgaaaa aacacttgat aaacttgaaa tcacaaaagt caaatctgat
   103801 gaaactgaaa ccattgacct agaccacctc tttgtcaact atggtttcaa atcttctgtc
   103861 ggtaacctta aaaactgggg gctcgacctc aaccgtcaca agattatcgt caacagcaaa
   103921 caggaatcca gccaagcagg tatctatgct atcggtgact gctgctacta tgacggaaaa
   103981 attgatctga ttgcgacagg cctcggagaa gctccaactg ctgtcaacaa cgctatcaac
   104041 tacattgacc ctgaacaaaa agtacaacca aaacactcta ctagtttata aaaaaaaacc
   104101 acgagtcaca taggattcgt ggttttataa ttcatccgca tttaaaaata cctttacatc
   104161 gttttactat atcttacaat accttttaaa acagctatat tttgagcttt taaataaatg
   104221 tttttacatc attttacaga gatttacgac acttttgccc cttttttgcc ccttttgagc
   104281 aaacaaaaaa accgcaagcc tgagcctgcg gtgaaagaac aatttagaaa gtttcctttc
   104341 tatttattta actgtaatca agccatctgg ctctactgtg aactctggct tgtctgccat
   104401 gctaccgtct ggtttgaggt agtaccagcc tgttccgtcc gctgactgga taaaggc
//
LOCUS       DAVLHC010000002        70671 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.002, whole genome shotgun sequence.
ACCESSION   DAVLHC010000002 DAVLHC010000000
VERSION     DAVLHC010000002.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 70671)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 70671)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..70671
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.002"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            49..1734
                     /locus_tag="VXE25_000109"
     CDS             49..1734
                     /locus_tag="VXE25_000109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000753868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="leucine-rich repeat protein"
                     /protein_id="HEV0770650.1"
                     /translation="MKKTTILSLTTAAVILAAYVPNEPILADTPSSEVIKETKVGSII
                     QQNNIKYKVLTVEGNIGTVQVGNGVTPVEFEAGQDGKPFTIPTKITVGDKVFTVTEVA
                     SQAFSYYPDETGRIVYYPSSITIPSSIKKIQKKGFHGSKAKTIIFDKGSQLEKIEDRA
                     FDFSELEEIELPASLEYIGTSAFSFSQKLKKLTFSSSSKLELISHEAFANLSNLEKLT
                     LPKSVKTLGSNLFRLTTSLKHVDVEEGNESFASVDGVLFSKDKTQLIYYPSQKNDESY
                     KTPKETKELASYSFNKNSYLKKLELNDGLEKIGTFAFADAIKLEEISLPNSLETIERL
                     AFYGNLELKELILPDNVKNFGKHVMNGLPKLKSLTIGNNINSLPSFFLSGVLDSLKEI
                     HIKNKSTEFSVKKDTFAIPETVKFYVTSEHIKDVLKSNLSTSNDIIVEKVDNIKQETD
                     VAKPKKNSNQGVVGWVKDKGLWYYLNESGSMATGWVKDKGLWYYLNESGSMATGWVKD
                     KGLWYYLNESGSMATGWFTVSGKWYYTYNSGDLLVNTTTPDGYRVNANGEWVG"
     gene            complement(2226..2375)
                     /gene="rpmG"
                     /locus_tag="VXE25_000110"
     CDS             complement(2226..2375)
                     /gene="rpmG"
                     /locus_tag="VXE25_000110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001265622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L33"
                     /protein_id="HEV0770651.1"
                     /translation="MRVNITLEHKESGERLYLTSKNKRNTPDRLQLKKYSPKLRKHVV
                     FTEVK"
     gene            complement(2391..2573)
                     /gene="rpmF"
                     /locus_tag="VXE25_000111"
     CDS             complement(2391..2573)
                     /gene="rpmF"
                     /locus_tag="VXE25_000111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000290417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L32"
                     /protein_id="HEV0770652.1"
                     /translation="MAVPARRTSKAKKNKRRTHYKVTAPSVNFDETTGDYSRSHRVSL
                     KGYYKGRKITKAASAE"
     gene            complement(2725..2925)
                     /locus_tag="VXE25_000112"
     CDS             complement(2725..2925)
                     /locus_tag="VXE25_000112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS ascorbate transporter subunit IIC"
                     /protein_id="HEV0770653.1"
                     /translation="MAEAKKKQIPLRLSTKLYAALASWAEDDFRSVNGQIEYLLTECV
                     KQRKKDGKYVSETIDEPFEIDI"
     gene            complement(2928..3935)
                     /locus_tag="VXE25_000113"
     CDS             complement(2928..3935)
                     /locus_tag="VXE25_000113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPFH domain-containing protein"
                     /protein_id="HEV0770654.1"
                     /translation="MTEKLINSKPNGVFALILIELTIVLGIFIFIMGVGSENIFGIII
                     GPLLIVIAGLAHAGLKVVKPQEALVLTLFGNYTGTIKEPGFYFVNPFSVAVNPANHTR
                     LGQSGDVSTKSPFLGAKSSNDNDVNLEIGKKHISLKVMTLSNSRQKINDCLGNPVEIG
                     IAVTWRVVDTAKAVFNVDNYKEYLSLQCDSALRNIVRIYPYDVSPNVDTTGDGQADEG
                     SLRGSSEIVANRIREEIQSRVEDAGLEILEARITYLAYAPEIAAVMLQRQQASAIIDA
                     RKMIVDGAVGMVEMALKRLNEGELVELDEERKAAMVSNLLVVLCGNHDAQPIVNTGSL
                     Y"
     gene            4126..6156
                     /locus_tag="VXE25_000114"
     CDS             4126..6156
                     /locus_tag="VXE25_000114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000460919.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BglG family transcription antiterminator"
                     /protein_id="HEV0770655.1"
                     /translation="MFDYRALVILMTLMDHCELSLYELSVKVSLPIKEVKEGIDYLVP
                     YLANKGIVLDKKQGRYSLSNRTKQSLTDIIKSDELVLPKSTRLALIYLYTFCRLDFIS
                     NSHYQDFLKVSKNTTLSDIQSLRKIMLDNDLELGYSRAKGYTLHGSEWNKHRLAFQMV
                     SELLESSIGIWGLDYVLSSWGYSLTYDLIDQVVKDYYEKLQLVPIVNQLKVYLFGLVF
                     ILCRYQRDVERVCLSETLVSPVIQDITTILLDTVVDLGIIDTVFSEDDYRYITVLLSS
                     CFEGEVDVAPVYFNQLTEAIISRMEDISLLHFKQREGLRENLRRHLIPAYYRLKFGLP
                     SSNEYVLHVKEHYPDLFELVKDSLMPLMDAIDNPIPDSETAYFVIHFGGYLKKADTLP
                     QKWYKAAIICPNGVSSSLMLKENLLALFPQIEFIGTSKIDDLQVKASSDYDMVFSTIK
                     VETEKPNYLVSVMMTEEQAIQLVELVLKDFPNLEYGDFEIEQILNIVKRYGIITQELE
                     LRLALKNYLYQKNDRKEIVPVLEQLITKETYQVSSQKLGWKEAIRLAAKPLLDQDKIT
                     ENYPEAMIQKVEEFGPFINLGKGVAIPHARPDEGVNEIGMSMLVLEEPIYLLDNPEQE
                     VRLLICIAAIDNESHLKALSHLTTILRDKNHVQTLISSKNYNDIKMIIKQED"
     gene            6160..6444
                     /locus_tag="VXE25_000115"
     CDS             6160..6444
                     /locus_tag="VXE25_000115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008089859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEV0770656.1"
                     /translation="MLKIGTACGSGLGSSFMVQMNIESVLSDLNVSDVEVEHYDLGGA
                     DPNAADIWIVGRDLADSASHLGDVRILNSIIDMDELRELITKLCEEKGLI"
     gene            6457..7803
                     /locus_tag="VXE25_000116"
     CDS             6457..7803
                     /locus_tag="VXE25_000116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000975284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS ascorbate transporter subunit IIC"
                     /protein_id="HEV0770657.1"
                     /translation="MMKFILDIVSTPAILVALIAILGLVLQKKKLPDIIKGGIKTFVG
                     FLVVSGGAGIVQNSLNPFGTMFEHAFHLSGVVPNNEAIVAVALTTYGSATAMIMFAGM
                     VFNILIARFTRFKYIFLTGHHTLYMACMIAVILSVAGFTSLPLILLGGLALGIIMSIS
                     PAFVQKYMVQLTGNDKVALGHFSSLGYWLSGFTGSLIGDKSKSTEDIKFPKSLAFLRD
                     STVSITLSMAVIYIIVAIFAGSEYIEKEISSGTSGLVYALQLAGQFAAGVFVILAGVR
                     LILGEIVPAFKGISERLVPNSKPALDCPIVYTYAPNAVLIGFISSFIGGLVSMAIMIA
                     SGTVVILPGVVPHFFCGATAGVIGNASGGVRGATIGAFLQGILISFLPVFLMPVLGGL
                     GFQGSTFSDADFGLSGIILGMLNQFGSQAGIVIGLVLILAVMFGVSFIKKPSAKEE"
     gene            7807..8664
                     /locus_tag="VXE25_000117"
     CDS             7807..8664
                     /locus_tag="VXE25_000117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase"
                     /protein_id="HEV0770658.1"
                     /translation="MILSKNREDELRKFATNIRLNTLRTLNHLGFGHYGGSLSIVEVL
                     AVLYGEIMPMTPEIFAARDRDYFILSKGHGGPALYSTLYLNGFFDKEFLYSLNTNGTK
                     LPSHPDRNLTPGIDMTTGSLGQGISVATGLAYGQRIRKSPFYTYAIVGDGELNEGQCW
                     EAIQFASHQQLSNLIVFVDENKKQLDGFTKDICNPGDFVEKFSAFGFESIRVKGSDIR
                     EIYEGIVQLKQSNNSSPKCIVLDTIKGQGVQELEEMKSNHHLRPTVEEKQMLTSVVER
                     LSQELEETE"
     gene            8661..9593
                     /locus_tag="VXE25_000118"
     CDS             8661..9593
                     /locus_tag="VXE25_000118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase family protein"
                     /protein_id="HEV0770659.1"
                     /translation="MMRSTKELRHVYRDFLLEANQSDSDIVVLEADLSSSMATHNLEK
                     DFGDRYVNVGIMEAEMVGLAAGLSIQGFRPYLHTFGPFASRRVFDQLFISLGYAQLDA
                     TVIGSDAGVTAEMNGGTHMPFEEIGLLRLIPKSIIFEATDDIQFREILNQTLDLKGLK
                     YIRTIRKAPVPVYQGGEDFSKGYIELRHGEDLVIVASGIMVAPSIRVADELSKLGYSV
                     GVIDLFRIKPIPEQIKTMLSGKTIFTVENHNQIGGIGSALCELFSDDGITKIHRMGVQ
                     ERFGQVGKMDYLLNEYGLSESNIKEKVLEIYNAR"
     gene            9826..11529
                     /gene="ilvD"
                     /locus_tag="VXE25_000119"
     CDS             9826..11529
                     /gene="ilvD"
                     /locus_tag="VXE25_000119"
                     /EC_number="4.2.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000137341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroxy-acid dehydratase"
                     /protein_id="HEV0770660.1"
                     /translation="MTELDKRHRSSIYDSMVKSPNRAMLRATGMTDKDFETPIVGVIS
                     TWAENTPCNIHLHDFGKLAKEGVKSAGAWPVQFGTITVADGIAMGTPGMRFSLTSRDI
                     IADSIEAAMSGHNVDAFVAIGGCDKNMPGSMIAIANMDIPAIFAYGGTIAPGNLDGKD
                     IDLVSVFEGIGKWNHGDMTAEDVKRLECNACPGPGGCGGMYTANTMATAIEVLGMSLP
                     GSSSHPAESADKKEDIEAAGRAVVKMLELGLKPSDILTREAFEDAITVTMALGGSTNA
                     TLHLLAIAHAANVDLSLEDFNTIQERVPHLADLKPSGQYVFQDLYEVGGVPAVMKYLL
                     ANGFLHGDRITCTGKTVAENLADFADLTPGQKVIMPLENPKRADGPLIILNGNLAPDG
                     AVAKVSGVKVRRHVGPAKVFDSEEDAIQAVLTDEIVDGDVVVVRFVGPKGGPGMPEML
                     SLSSMIVGKGQGDKVALLTDGRFSGGTYGLVVGHIAPEAQDGGPIAYLRTGDIVTVDQ
                     DTKEISMAVSEEELEKRKAETTLPPLYSRGVLGKYAHIVSSASRGAVTDFWNMDKSGK
                     K"
     gene            complement(11738..12079)
                     /locus_tag="VXE25_000120"
     CDS             complement(11738..12079)
                     /locus_tag="VXE25_000120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003080443.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-sulfur cluster assembly factor"
                     /protein_id="HEV0770661.1"
                     /translation="MRDDIKINDRALALQDQIIEKLEKVFDTDVELDVYNLGLIYEIN
                     LDETGLCKIVMTFTDTACDCAESLPIEIVAGLKQIEGIKDIKVEVTWSPAWKITRISR
                     YGRIALGLPPR"
     gene            12203..13054
                     /gene="rgg"
                     /locus_tag="VXE25_000121"
     CDS             12203..13054
                     /gene="rgg"
                     /locus_tag="VXE25_000121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000434947.1"
                     /note="Rgg, as the term is used in Streptococcus
                     pneumoniae, is the lone quorum-sensing system
                     transcriptional regulator related to proteins Rgg1, Rgg2,
                     Rgg3, and Rgg4 of Streptococcus pyogenes; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quorum-sensing system transcriptional regulator
                     Rgg"
                     /protein_id="HEV0770662.1"
                     /translation="MEQIGKVFRQLRESRNISLRQATGGQFSPSMLSRFETGQSELSV
                     EKFLFALENISASVEEILFLARGFQYDTDSELRKEITDVLEPKNIAPLEDLYRREYQK
                     HAHSHNKQKHILNAIIIKSYMKSMDERVELTAEEGKVLHDYLFSTEIWGIYELNLFSV
                     SSPFLSVSLFTRYVREMVRKSDFLMEMSGNRNLFHTILLNGFLASIECEEFTNAYYFK
                     RVIEEHFYKENETYFRIVYLWAEGLLDSKQGRVKEGQKKMEDAVRIFEMLGCNKSAEY
                     YRNTTEC"
     gene            13247..14494
                     /locus_tag="VXE25_000122"
     CDS             13247..14494
                     /locus_tag="VXE25_000122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter"
                     /protein_id="HEV0770663.1"
                     /translation="MKLLFRNPAYRILILSRFFNAFGASIFNLVFIVYASTLSQASFA
                     VAMANIVMILPTLFTVFVGIRADYTRDKVKWMVYSGLFQAVLFFLAALVVQQASLFAF
                     SSLCLINVISDIISDFAGGLRMPLIKEKVAEDDLMEAYSFSQFITYISAIGGQAFGVW
                     LLALSVNNFSLVAGINACFFLVSATILFLGKSKLSLSMSSADGENLKNEKLSIKDQFL
                     TIYRNLRLVFLKSGQKNFGFMLFAVLLINSLGGALGGIYNIFFLSHSLLNFSYTEALF
                     INQFCVLVAIIISSLTGNAYFGKQSLPRLMMWATVGLSLVGLANLFNQVVLGLLFLFF
                     TLYVSGKVQPKISAMLMKNLAPEVLARTSNFLGLLFTLSIPVGTACFSLVAVWNMQLT
                     WMLFVGLSLLAIFLTILNLKNDI"
     gene            14572..15861
                     /locus_tag="VXE25_000123"
     CDS             14572..15861
                     /locus_tag="VXE25_000123"
                     /EC_number="6.1.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine--tRNA ligase"
                     /protein_id="HEV0770664.1"
                     /translation="MKLQKPKGTQDILPAESAKWQYVEGFAREIFKRYNYAEVRTPIF
                     EHYEVISRSVGDTTDIVTKEMYDFYDKGDRHITLRPEGTAPVVRSYVENKLFAPEVQK
                     PSKFYYMGPMFRYERPQAGRLRQFHQIGVECFGSSNPATDVETIVMAAHFLKEIGIQG
                     VKLHLNTLGNPESRAAYRQALIDYLTPLKETLSKDSQRRLEENPLRVLDSKEKEDKVA
                     VENAPSILDFLDEESQAHFDAVRQMLENLGVDYIIDTNMVRGLDYYNHTIFEFITEIE
                     GNDLTVCAGGRYDGLVAYFGGPETAGFGFGLGVERLLLILEKQGVALPIENALDVYIA
                     VLGDGANVKALELVQALRQQGFKAERDYLNRKLKAQFKSADVFATKTLITLGESEVES
                     GQVTVKNNQTREEVQVSLETISQNFSEIFEKLGFYTQ"
     gene            15852..15932
                     /locus_tag="VXE25_000124"
                     /pseudo
     CDS             15852..15932
                     /locus_tag="VXE25_000124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            16202..16516
                     /locus_tag="VXE25_000125"
     CDS             16202..16516
                     /locus_tag="VXE25_000125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829577.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0770665.1"
                     /translation="MWVLGFILFMIFFYSNNSKKIKKLENKIKKLERKEKGNAEMSRL
                     LQEMIGKEPIITGVYIGPDNWEVVDVDEEWVKLRSVDNTGKEKFKLQRIEDIQTVEFD
                     GE"
     gene            16526..16732
                     /locus_tag="VXE25_000126"
     CDS             16526..16732
                     /locus_tag="VXE25_000126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001176227.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEV0770666.1"
                     /translation="MQLKNRLKELRARDGLNQTDLAKLAGVSRQTISLLERDEYTPSI
                     IIALKISQIFNETVESVFRLEEDE"
     gene            16732..16929
                     /locus_tag="VXE25_000127"
     CDS             16732..16929
                     /locus_tag="VXE25_000127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001046145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0770667.1"
                     /translation="MNKYKVIYYVVVIALLVSVFLLIGMDLSWFNPYQSDQFVWVYFA
                     LIPVTEWIEKKSKNLASEKGE"
     gene            16932..17666
                     /locus_tag="VXE25_000128"
     CDS             16932..17666
                     /locus_tag="VXE25_000128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3169 family protein"
                     /protein_id="HEV0770668.1"
                     /translation="MKKKRRLLFLMSIVLGGFLGMFVGMFKARVESHEIILDVKALMP
                     WISAICLLIGFISMFLTFNFLKKSRKFHSLYQEEMDDDLNETYYVQMYRNLEFGTIAF
                     NIIGVAIPLAIFISLSEVIILHTNPQTFFLSFLLFVVFLVAQKSLFKTIAIVRQFDLE
                     FFATPKDVLNYINSYDEGERQANLEQSFRILFQLHQYVLPALYIFLIIISFLTGEIQL
                     LAFLLVGAIHVYINVMQLPMVKRYFK"
     gene            17678..18319
                     /locus_tag="VXE25_000129"
     CDS             17678..18319
                     /locus_tag="VXE25_000129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEV0770669.1"
                     /translation="MKLLKNLGWILLALLSFLFIYGFIQGLATASLALGASPYAVTLL
                     YVALAGVYVYGIYKWYQKAPVHIEKSGFNRFIWLPVLVWFLSLVVQFFLPDDPSVNQQ
                     IATDLTLSQPLFSFFAVVIFAPLTEEIVFRGMLARYLFPKQDNSKRTLIFLLVSSLLF
                     ALIHFPGDVQQFFVYFSLGFSLGLAYVSRKGLVYSISLHALNNLVGFLMILML"
     gene            18337..18567
                     /locus_tag="VXE25_000130"
     CDS             18337..18567
                     /locus_tag="VXE25_000130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000832182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0770670.1"
                     /translation="MKRVILLAVIQAVVLFFIIGALAYAFKGDFFYNYLAVVFAPIAG
                     VLRFGTAYITEIVLPRKAAEIAEKRKAGKNSK"
     gene            18603..18683
                     /locus_tag="VXE25_000131"
                     /pseudo
     CDS             18603..18683
                     /locus_tag="VXE25_000131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            18919..20682
                     /gene="aspS"
                     /locus_tag="VXE25_000132"
     CDS             18919..20682
                     /gene="aspS"
                     /locus_tag="VXE25_000132"
                     /EC_number="6.1.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000830881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate--tRNA ligase"
                     /protein_id="HEV0770671.1"
                     /translation="MKRSMYAGRVREEHIGQEITLKGWVGRRRDLGGLIFIDLRDREG
                     IMQLVINPEKVSAEVMATAESLRSEFVIEVTGQVAAREQANDKLPTGAVELNVTALIV
                     LNTAKTTPFEIKDGIEANDDTRLRYRYLDLRRPEMLENLKLRAKVTHSIRNYLDELEF
                     IDVETPFLSKSTPEGARDYLVPSRVNKGHFYALPQSPQITKQLLMNAGFDRYYQIVKC
                     FRDEDLRGDRQPEFTQVDLETSFLTEQEIQDITESLIARVMKETKGIEVTLPFPRMKY
                     DDAMALYGSDKPDTRFDMLLQDLTEVVRGVDFKVFSEAPAVKAIVVTGAADNYSRKDI
                     DKMTEVAKQYGAKGLAWVKVVDGELNGPVAKFLTGIQEELTTALVLEDKDLVLFVADT
                     LEVANATLGALRGRIAKELGLIDNDKFNFLWVVDWPMFEWSEEEGRYMSAHHPFTLPQ
                     EETAHELEGDLAKVRAIAYDIVLNGYELGGGSLRINQKDLQERMFKALGFSTEEANDQ
                     FGFLLEAMDYGFPPHGGLAIGLDRFVMLLAGEENIREVIAFPKNNKATDPMTQAPSTV
                     ALKQLEELSLQVEEDETNKTN"
     gene            20660..21601
                     /locus_tag="VXE25_000133"
     CDS             20660..21601
                     /locus_tag="VXE25_000133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000806289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HEV0770672.1"
                     /translation="MKQTKRIKRWRYYLRRFAYQIKILRVLQSISREKYDEKISASLV
                     YGFLSAVAVNFFFQPGHVYSSGATGLAQIISALSNHWFGFHIPISLTFYAINFPLMVL
                     AWYQIGHKFTVFTFITVSMSSFFIQFVPVATLTEDPIINALFGGVVMGLGIGFALRNN
                     ISSGGTDIVSLTIRKKTGKNVGSISFLVNGTIMLIAGLTFGWKYALYSMITIFVSSRV
                     TDAVFTKQKRMQAMIVTNHPEKVIEKIHKKLHRGATMIHDAEGTYNHERKAVLITVIT
                     RAEFNEFKQIMTQVDPSSFVSVSENVHILGRFVEIDN"
     gene            complement(21811..21891)
                     /locus_tag="VXE25_000134"
                     /pseudo
     CDS             complement(21811..21891)
                     /locus_tag="VXE25_000134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            complement(22027..23013)
                     /locus_tag="VXE25_000135"
     CDS             complement(22027..23013)
                     /locus_tag="VXE25_000135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001145427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEV0770673.1"
                     /translation="MPVTIKDVAKAAGVSPSTVTRVIQNKSTISDETKKRVRKAMKEL
                     NYHPNLNARSLVSSYTQVIGLVLPDDSDAFYQNPFFPSVLRGISQVASENHYAIQIAT
                     GKDEKERLNAISQMVYGKRVDGLIFLYAQEEDPLVKLVAEEQFPFLILGKSLSPFIPL
                     VDNDNVQAGFDATEYFIKKGCKRIAFIGGSKKLFVTKDRLTGYEQALKHYKLTTDNNR
                     IYFADEFLEEKGYKFSKRLFKHDPQIDAIITTDSLLAEGVCNYIAKHQLDVPVLSFDS
                     VNPKLNLAAYVDINSLELGRVSLETILQIINDNKNNKQICYRQLIAHKIIEK"
     gene            complement(23023..23823)
                     /locus_tag="VXE25_000136"
     CDS             complement(23023..23823)
                     /locus_tag="VXE25_000136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000938258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1189 domain-containing protein"
                     /protein_id="HEV0770674.1"
                     /translation="MLPYPFSYFSSIWGFRKPLSKRFELNWFQLLFTSIFLISLSMVP
                     IAIQNSSQETYPLETFIDNVYEPLTNEVVQDLSEHATIVDGTLTYTGTASQAPSVVIG
                     PSQIKELPKDLQLHFDTNELVISKESKELTRISYRAIQTESFKSKDSLTQAISKDWYQ
                     QNRVYISLFLVLGASFLFGLNFFIVSLGASLLLYITKKSRLFSFRTFKECYHFILNCL
                     GLPTLITLILGLFGQNMTTLITVQNILFVLYLVTIFYKTHFRDPNYHK"
     gene            complement(24084..24926)
                     /locus_tag="VXE25_000137"
     CDS             complement(24084..24926)
                     /locus_tag="VXE25_000137"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001065636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEV0770675.1"
                     /translation="MNNSIKLKRRLTQSLTYLYLIGLSIVIIYPLLITIMSAFKAGNV
                     SAFKLDTNIDLNFDNFKGLFTETLYGTWYLNTLIIALITMAVQTSIIVLAGYAYSRYN
                     FLARKQSLVFFLIIQMVPTMAALTAFFVMALMLNALNHNWFLIFLYVGGGIPMNAWLM
                     KGYFDTVPMSLDESAKLDGAGHFRRFWQIVLPLVRPMVAVQALWAFMGPFGDYILSSF
                     LLREKEYFTVAVGLQTFVNNAKNLKIAYFSAGAILIALPICILFFFLQKNFVSGLTSG
                     GDKG"
     gene            complement(24928..26220)
                     /locus_tag="VXE25_000138"
     CDS             complement(24928..26220)
                     /locus_tag="VXE25_000138"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000414940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEV0770676.1"
                     /translation="MEKQQPSKAALLSIIPGLGQIYNKQKAKGFIFLGVTIVFVLYFL
                     ALATPELSNLITLGDKPGRDNSLFMLIRGAFHLIFVIVYVLFYFSNIKDAHTIAKRIN
                     NGIPVPRTLKDMIKGIYENGFPYLLIIPSYVAMTFAIIFPVIVTLMIAFTNYDFQHLP
                     PNKLLDWVGLTNFTNIWSLSTFRSAFGSVLSWTIIWALAASTLQIVIGIFTAIIANQP
                     FIKGKRIFGVIFLLPWAVPAFITILTFSNMFNDSVGAINTQVLPILAKFLPFLDGALI
                     PWKTDPTWTKIALIMMQGWLGFPYIYVLTLGILQSIPNDLYEAAYIDGANAWQKFRNI
                     TFPMILAVAAPTLISQYTFNFNNFSIMYLFNGGGPGSVGGGAGSTDILISWIYRLTTG
                     TSPQYSMAAAVTLIISIIVISISMIAFKKLHAFDMEDV"
     gene            complement(26331..27602)
                     /locus_tag="VXE25_000139"
     CDS             complement(26331..27602)
                     /locus_tag="VXE25_000139"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000095461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HEV0770677.1"
                     /translation="MSSKFMKSAAVLGTVTLASLLLVACGSKTADKPADSGSSEVKEL
                     TVYVDEGYKSYIEEVAKAYEKEAGVKVTLKTGDALGGLDKLSLDNQSGNVPDVMMAPY
                     DRVGSLGSDGQLSEVKLSDGAKTDDTTKSLVTAANGKVYGAPAVIESLVMYYNKDLVK
                     DAPKTFADLENLAKDSKYAFAGEDGKTTAFLADWTNFYYTYGLLAGNGAYVFGQNGKD
                     AKDIGLANDGSIVGINYAKSWYEKWPKGMQDTEGAGNLIQTQFQEGKTAAIIDGPWKA
                     QAFKDAKVNYGVATIPTLPNGKEYAAFGGGKAWVIPQAVKNLEASQKFVDFLVATEQQ
                     KVLYDKTNEIPANTEARSYAEGKNDELTTAVIKQFKNTQPLPNISQMSAVWDPAKNML
                     FDAVSGQKDAKTAANDAVTLIKETIKQKFGE"
     gene            28152..29669
                     /gene="malQ"
                     /locus_tag="VXE25_000140"
     CDS             28152..29669
                     /gene="malQ"
                     /locus_tag="VXE25_000140"
                     /EC_number="2.4.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847831.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-alpha-glucanotransferase"
                     /protein_id="HEV0770678.1"
                     /translation="MKKRQSGVLMHISSLPGAYGIGSFGQSAYDFVDFLVRTKQRYWQ
                     ILPLGATSYGDSPYQSFSAFAGNTHFIDLDILVEQGLLEASDLEGVDFGSDASEVDYA
                     KIYYARRPLLEKAVKRFFEVGDVKDFEKFAQDNQSWLELFAEYMAIKEYFDNLAWTEW
                     PDADARARKASALESYREQLADKLVYHRVTQYFFFQQWLKLKAYANDNHIEIVGDMPI
                     YVAEDSSDMWANPHLFKTDVNGKATCIAGCPPDEFSVTGQLWGNPIYDWEAMDKDGYK
                     WWIERLRESFKIYDIVRIDHFRGFESYWEIPAGSDTAAPGEWVKGPGYKLFAAVKEEL
                     GELNIIAEDLGFMTDEVIELRERTGFPGMKILQFAFNPEDESIDSPHLAPANSVMYTG
                     THDNNTVLGWYRNEIDDATREYMARYTNRKEYETVVHAMLRTVFSSVSFMAIATMQDL
                     LELDEAARMNFPSTLGGNWSWRMTEDQLTPAVEEGLLDLTTIYRRINENLVDLKK"
     gene            29695..31953
                     /gene="glgP"
                     /locus_tag="VXE25_000141"
     CDS             29695..31953
                     /gene="glgP"
                     /locus_tag="VXE25_000141"
                     /EC_number="2.4.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000950172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycogen/starch/alpha-glucan family
                     phosphorylase"
                     /protein_id="HEV0770679.1"
                     /translation="MLSLQEFVQNRYNKTIAECSNEELYLALLNYSKLASSQKPVNTG
                     KKKVYYISAEFLIGKLLSNNLINLGLYDDVKKELAAAGKDLIEVEEVELEPSLGNGGL
                     GRLAACFIDSIATLGLNGDGVGLNYHFGLFQQVLKNNQQETIPNAWLTEQNWLVRSSR
                     SYQVPFADFTLTSTLYDIDVTGYETATKNRLRLFDLDSVDSSIIKDGINFDKTDIARN
                     LTLFLYPDDSDRQGELLRIFQQYFMVSNGAQLIIDEAIEKGSNLHDLADYAVVQINDT
                     HPSMVIPELIRLLTARGIELDEAISIVRSMTAYTNHTILAEALEKWPLEFLQEVVPHL
                     VPIIEELDRRVKAEYKDPAVQIIDESGRVHMAHMDIHYGYSVNGVAALHTEILKNSEL
                     KAFYDLYPEKFNNKTNGITFRRWLMHANPRLSHYLDEILGDGWHHEADELEKLLSYED
                     KAAVKEKLESIKAHNKRKLARHLKEHQGVEINPNSIFDIQIKRLHEYKRQQMNALYVI
                     HKYLDIKAGNIPARPITIFFGGKAAPAYTIAQDIIHLILCMSEVIANDPAVAPHLQVV
                     MVENYNVTAASFLIPACDISEQISLASKEASGTGNMKFMLNGALTLGTMDGANVEIAE
                     LVGDENIYIFGEDSETVIDLYAKAAYKSSEFYAREAIKPLVDFIVSDAVLAAGNKERL
                     ERLYNELINKDWFMTLLDLEDYIKVKEQMLADYEDRDAWLDKVIVNISKAGFFSSDRT
                     IAQYNEDIWHLN"
     gene            complement(32998..33570)
                     /locus_tag="VXE25_000142"
     CDS             complement(32998..33570)
                     /locus_tag="VXE25_000142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0770680.1"
                     /translation="MNKLMKFISVFLTSIVLIVSAIPSVSAVYASEQVSQIETNMELQ
                     PVTSLTEEQINTLANEIQSFHPDVSQQWIKEVINRQLQGDYTIPPTYSPFRAAWQGIT
                     VNQMGALLDTAIALALGGTTAGLANLIKVKGKHAAKSAIRSAISRYLGSWFVNDVALE
                     FAMNLLSPGTYLAQLWDKNDAIPNNRRINF"
     gene            complement(34414..35262)
                     /locus_tag="VXE25_000143"
     CDS             complement(34414..35262)
                     /locus_tag="VXE25_000143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001095523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HEV0770681.1"
                     /translation="MNTNLKPKLQRFASATAFACPICQENLTLLETNFKCCNHHSFDL
                     AKFGYVNLAPQIKQSANYDKENFQNRQQILEAGFYQAILDAVSDLLASSKTTTTILDI
                     GCGEGFYSRKLQESHSEKTFYAFDISKDSVQIAAKSEPNWAVNWFVGDLARLPIKDAS
                     MDILLDIFSPANYGEFRRVLSKDGILIKVIPTENHLKEIRQRVQDQLTNKEYSNQDIK
                     EHFQEHFTILSSQTASLTKTITAEQLQALLSMTPLLFHVDQSKIDWSQLTEITIEAEI
                     LVGKAF"
     gene            35414..35692
                     /locus_tag="VXE25_000144"
     CDS             35414..35692
                     /locus_tag="VXE25_000144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003075836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0770682.1"
                     /translation="MLKEVLTVAKVAKKSSLFLGGVAFGTLGLKILASKEAKKGYSKA
                     LAKAYKLKDELDASVSVVKQHGDDVLQDAKYLYEQEKKEEQLDSLIGE"
     gene            35694..37757
                     /locus_tag="VXE25_000145"
     CDS             35694..37757
                     /locus_tag="VXE25_000145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000008803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heavy metal translocating P-type ATPase"
                     /protein_id="HEV0770683.1"
                     /translation="MSFKVLHRGYQHIRLSSSFSLTLDIQDYLRSLARDEKGIESIQF
                     YMDQQHFTLRIKEGFSVLDNAEAFLKRIDKGKVSELMTLPIRREESAYSIVSGAAVKR
                     VLFRSFVPYPIRYIWTCYQALGYIREAYQTLARKELTMEVLDCSAILLSLFMNQSKTA
                     SNIMFMLDLGNHLDQWSLKKTATDLEQSLLAKESDVFLVQGDTVVSIKSSDVQIGDVL
                     ILSQGNEILFDGQVVSGLGMVNESSLTGESFPVEKRESDLVCANTVLETGELRIRVTD
                     NQMNSRILQLIELMKKSEENKKTKQRYFIKMADKVVKYNFLGAGLTYLLTGSFSKAIS
                     FLLVDFSCALKISTPVAYLTVIKEGLNREMVIKDGDVLEKYLEVDTFLFDKTGTITTS
                     YPIVEKVLPFGDYSEEDILRISACLEEHIYHPIANAIVKQAEIEGIEHEEMHGKLQYI
                     ASKGIKSHIDGQPVLIGNYVLMQDEQIHISSEQNALIEEYKSHYNLLFLAYQNELIGM
                     FCIHTPLRKEAKTALDKLKAQGKKLILATGDTLIRTEELVKDLPFDQVYTDLKPDGKF
                     ELVEKLQKAGHTILMVGDGLNDSAALTLSDIGVVMNESADISKQMSDILLLDNRLDFF
                     QELDSLSSSLQTLIKKNIQDTVVVNSSLIGFGLFNWFSPSNLSILHNLTTLRIVLRSL
                     SIKNR"
     gene            complement(37835..39091)
                     /locus_tag="VXE25_000146"
     CDS             complement(37835..39091)
                     /locus_tag="VXE25_000146"
                     /EC_number="6.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000546895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine--tRNA ligase"
                     /protein_id="HEV0770684.1"
                     /translation="MHIFDELKDRGLIFQTTDEEALRKALEEGQVSYYTGYDPTADSL
                     HLGHLVAILTSRRLQLAGHKPYALVGGATGLIGDPSFKDAERSLQTKDTVDGWVKSIQ
                     GQLSRFLDFENGENKAVMVNNYDWFGSISFIDFLRDIGKYFTVNYMMSKESVKKRIET
                     GISYTEFAYQIMQGYDFFVLNQDHNVTLQIGGSDQWGNMTAGTELLRRKADKTGHVIT
                     VPLITDATGKKFGKSEGNAVWLNPEKTSPYEMYQFWMNVMDADTVRFLKIFTFLSLDE
                     IEDIRKQFEAAPHERLAQKVLAREVVTLVHGEEAYKEALNITEQLFAGNIKNLSVKEL
                     KQGLRGVPNYQVQADENNNIVELLVSSGIVNSKRQAREDVQNGAIYVNGDRIQDLDYV
                     LSDADKLENELTVIRRGKKKYFVLTY"
     gene            39233..41695
                     /locus_tag="VXE25_000147"
     CDS             39233..41695
                     /locus_tag="VXE25_000147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein"
                     /protein_id="HEV0770685.1"
                     /translation="MQNQLNELKRKMLEFFQQKQKNKKSARPGKKGSSTKKSKTLDKS
                     AIFPAILLSIKALFNLLFVLGFLGGMLGAGIALGYGVALFDKVRVPQTEELVNQVKDI
                     SSISEITYSDGTVIASIESDLLRTSISSEQISENLKKAIIATEDEHFKEHKGVVPKAV
                     IRATLGKFVGLGSSSGGSTLTQQLIKQQVVGDAPTLARKAAEIVDALALERAMNKDEI
                     LTTYLNVAPFGRNNKGQNIAGARQAAEGIFGVDASQLTVPQAAFLAGLPQSPITYSPY
                     ENTGELKSDEDLEIGLRRAKAVLYSMYRTGALSKDEYSQYKDYDLKQDFLPSGTVTGI
                     SRDYLYFTTLAEAQERMYDYLAQRDNVSAKELKNEATQKFYRDLAAKEIENGGYKITT
                     TIDQKIHSAMQSAVADYGYLLDDGTGRVEVGNVLMDNQTGAILGFVGGRNYQENQNNH
                     AFDTKRSPASTTKPLLAYGIAIDQGLMGSETILSNYPTNFANGNPIMYANSKGTGMMT
                     LGEALNYSWNIPAYWTYRMLREKGVDVKGYMEKMGYEIPEYGIESLPMGGGIEVTVAQ
                     HTNGYQTLANNGVYHQKHVISKIEAADGRVVYEYQDKPVQVYSKATATIMQGLLREVL
                     SSRVTTTFKSNLTSLNPTLANADWIGKTGTTNQDENMWLMLSTPRLTLGGWIGHDDNH
                     SLSRRAGYSNNSNYMAHLVNAIQQASPSIWGNERFALDPSVVKSEVLKSTGQKPGKVS
                     VEGKEVEVTGSTVTSYWANKSGAPATSYRFAIGGSDADYQNAWSSIVGSLPTPSSSSS
                     SSSSSSDSSNSSTTRPSSRARR"
     gene            41760..42671
                     /locus_tag="VXE25_000148"
     CDS             41760..42671
                     /locus_tag="VXE25_000148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007285066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EamA family transporter"
                     /protein_id="HEV0770686.1"
                     /translation="MNQYQKKIVNGKIYSLLSGLIWGICGILGEYFFTHYQVSSGWIT
                     SMRLTLAGSLVLIWSAIQLKSQVLDIWRDKKNYLPFLAYAILGIFSVQYFFYLCVEYS
                     NATTATILQFISPVFILFYNRLVYQKRASKSAVFYVLVAMLGVCLMATKGDLSQLSMT
                     PLALITGLLSAMGVMFNVILPQPFAKRYGFVPTVGWGMILAGLFSNVLSPVYQLSFTL
                     DIWSILICLIIAFFGTAFAFFISMKAVSLVSPLVVAVISASEPLSSALLSVLFLGLVV
                     DWSLLLAIALIILPMIFLSIEEAKESR"
     gene            42901..43599
                     /gene="dapD"
                     /locus_tag="VXE25_000149"
     CDS             42901..43599
                     /gene="dapD"
                     /locus_tag="VXE25_000149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466315.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2,3,4,5-tetrahydropyridine-2,6-dicarboxylate
                     N-acetyltransferase"
                     /protein_id="HEV0770687.1"
                     /translation="MTATKMNAQEIIQFIANAEKKTSVKVTFEGQLATAVPSSVVKLG
                     NVLFGDWKDVAPLLEGLVENQDYVVEQDARNSAVPLLDKRAINARIEPGAIIRDQVEI
                     GDNAVIMMGAVINIGAEIGAGTMIDMGAILGGRAIVGKNSHVGAGAVLAGVIEPASAE
                     PVRVGDNVLIGANAVVIEGVQIGSGSVVAAGAIVTQDVPENVVVAGVPARIIKEIDAQ
                     TQQKTALEDALRTL"
     gene            43667..44797
                     /locus_tag="VXE25_000150"
     CDS             43667..44797
                     /locus_tag="VXE25_000150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetyldiaminopimelate deacetylase"
                     /protein_id="HEV0770688.1"
                     /translation="MLDLIQTRRALHQIPEIGLEEFKTQAYLLDVIEKLTTGKDFVQI
                     RTWRTGILVYLQGSQPERTIGWRTDIDGLPIVEQTGLPFASQHQGRMHACGHDFHMTI
                     ALGCLERALEEQPKNNLLFLFQPAEENEAGGMLMYEDGAFGDWLPNQFYGLHVRPDLK
                     VGQIATNTHTLFAGTCEVKIRFKGKGGHAAFPHEANDALVAASYFVTQVQSVVSRNVN
                     PIEGAVVTFGVFQAGTTNNVITDTAFLHGTIRALTQDMSLLVQKRVKTVAEGVAAAFD
                     MEVEVELKQGGYLPVENNPALARELMDFFDEKDGIELIDIEPAMTGEDFGYLLSKVDG
                     VMFWLGIDSPYALHHPQMSPKEEVLAIGVAAVSSFLKKKAAE"
     gene            44809..45348
                     /locus_tag="VXE25_000151"
     CDS             44809..45348
                     /locus_tag="VXE25_000151"
                     /EC_number="6.3.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-formyltetrahydrofolate cyclo-ligase"
                     /protein_id="HEV0770689.1"
                     /translation="MKSELRKQVLQGMKAISQEQKQFIDQTLTERLLHHPFYQEAKVI
                     ATYLSFSHEFQTRELIEQALKDGKKVLIPKTYPKGRMDFVVYDLQQLVKTAFALLEPQ
                     GDLEVVDVSQIDLIHVPGLAFTTDGYRIGYGGGYYDRYLEHFSGHTLSTVHPCQIQDF
                     IPENHDIPVQEVLIDEGNL"
     gene            45332..46009
                     /locus_tag="VXE25_000152"
     CDS             45332..46009
                     /locus_tag="VXE25_000152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhomboid family intramembrane serine protease"
                     /protein_id="HEV0770690.1"
                     /translation="MKEIFDRRYPVTSFFLLVTALVFLLMLVTAGGNFDRADTLFRFG
                     AMYGPAIRLFPEQVWRLLSAIFVHIGWEHFIVNMLSLYYLGRQVEEIFGSKQFFFLYL
                     LSGMMGNLFVFVFSPKSLAAGASTSLYGLFAAIIVLRYATRNPYIQQLGQSYLTLFVV
                     NIIGSVLIPGISLAGHIGGAVGGAFLAVIFPVRGEKRMYNTSQRLGAVVLFVGLAILL
                     FYKGMGM"
     gene            complement(46076..46975)
                     /gene="galU"
                     /locus_tag="VXE25_000153"
     CDS             complement(46076..46975)
                     /gene="galU"
                     /locus_tag="VXE25_000153"
                     /EC_number="2.7.7.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000202216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UTP--glucose-1-phosphate uridylyltransferase
                     GalU"
                     /protein_id="HEV0770691.1"
                     /translation="MTSKVRKAVIPAAGLGTRFLPATKALAKEMLPIVDKPTIQFIVE
                     EALKSGIEDILVVTGKSKRSIEDHFDSNFELEYNLKEKGKTDLLKLVDETTGMRLHFI
                     RQTHPRGLGDAVLQAKAFVGNEPFVVMLGDDLMDITDEKTVPLTKQLMDDYERTHAST
                     IAVMPVPHDEVSAYGVIAPQGEGKDGLYSVETFVEKPAPEDAPSDLAIIGRYLLTPEI
                     FEILEKQAPGAGNEIQLTDAIDTLNKTQRVFAREFTGARYDVGDKFGFMKTSIDYALK
                     HPQVKDDLKNYLIQLGKELTEKE"
     gene            complement(46997..48013)
                     /locus_tag="VXE25_000154"
     CDS             complement(46997..48013)
                     /locus_tag="VXE25_000154"
                     /EC_number="1.1.1.94"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000415108.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent glycerol-3-phosphate
                     dehydrogenase"
                     /protein_id="HEV0770692.1"
                     /translation="MEKQTVAVLGPGSWGTALSQVLNDNGHEVRIWGNLPEQINEINT
                     HHTNKHYFKDVVLDENIIAYTDLAETLKNVDAILFVVPTKVTRLVAQQVAQTLDHKVI
                     IMHASKGLEPDSHKRLSTILEEEIPEHLRSDIVVVSGPSHAEETIVRDLTLITAASKD
                     LQTAQYVQELFSNHYFRLYTNTDVIGVETAGALKNIIAVGAGALHGLGFGDNAKAAII
                     ARGLAEITRLGVALGASPLTYSGLSGVGDLIVTGTSIHSRNWRAGDALGRGESLADIE
                     ANMGMVIEGISTTRAAYELAQELGVYMPITQAIYQVIYHGTNIKDAIYDIMNNEFKAE
                     NEWS"
     gene            48225..48600
                     /locus_tag="VXE25_000155"
                     /pseudo
     CDS             48225..48600
                     /locus_tag="VXE25_000155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809823.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="XRE family transcriptional regulator"
     gene            complement(48780..49205)
                     /locus_tag="VXE25_000156"
     CDS             complement(48780..49205)
                     /locus_tag="VXE25_000156"
                     /inference="COORDINATES: protein motif:HMM:NF025080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEV0770693.1"
                     /translation="MTNLSSVDSEELFQFYRERGNAENFIKERKAGFFGDKTDSSTMI
                     KNEVRMMMGCLAYNLYLFLKQLAGDEVKALTIKRFRRLFLHIAGKYVSTARRHILKFS
                     SLYAYSKQFQALFDTICQINLILPVPYRARGQGKTCLTE"
     gene            complement(49273..49923)
                     /gene="phoU"
                     /locus_tag="VXE25_000157"
     CDS             complement(49273..49923)
                     /gene="phoU"
                     /locus_tag="VXE25_000157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001245788.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate signaling complex protein PhoU"
                     /protein_id="HEV0770694.1"
                     /translation="MRNQFDLELHELEQSFLGLGQLVLETASKTLLALASKDKEMAEL
                     IINKDHAINQGQSAIELTCARLLALQQPQVSDLRFVISIMSSCSDLERMGDHMAGIAK
                     AVLQLKENQLAPDEEQLHQMGKLSLSMLSDLLVAFPLHQASKAISIAQKDEQIDQYYY
                     ALSKEIIGLMKDQETSIPNGTQYLYIIGHLERFADYIANICERLVYLETGELVDLN"
     gene            complement(49938..50690)
                     /gene="pstB"
                     /locus_tag="VXE25_000158"
     CDS             complement(49938..50690)
                     /gene="pstB"
                     /locus_tag="VXE25_000158"
                     /EC_number="7.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003101281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter ATP-binding protein"
                     /protein_id="HEV0770695.1"
                     /translation="MGTFSVRHLDLFYGDFQALKNISIQLPERQITALIGPSGCGKST
                     FLKTLNRMNDLVPSCHIEGQVLLDEQDIYSSKFNLNQLRKRVGMVFQQPNPFAMSIYD
                     NVAYGPRTHGIRDKKQLDALVEKSLKGAAIWDEVKDNLKKSAMSLSGGQQQRLCIARA
                     LAVEPDVLLMDEPTSALDPISTLKIEDLIQQLKKDYTIIIVTHNMQQASRISDKTAFF
                     LTGEICEFGDTVDVFTNPKDQRTEDYISGRFG"
     gene            complement(50692..51507)
                     /gene="pstA"
                     /locus_tag="VXE25_000159"
     CDS             complement(50692..51507)
                     /gene="pstA"
                     /locus_tag="VXE25_000159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease PstA"
                     /protein_id="HEV0770696.1"
                     /translation="MSKYLLKLLVYCFSALTFGSLFLIIGFILIKGLPHLSLSLFSWT
                     YTSENISLMPAIISTVILVFGALLLALPIGIFAGFYLVEYTKKDSLCVKIMRLASDTL
                     SGIPSIVFGLFGMLFFVVFLGFQYSLLSGILTSVIMVLPVIIRSTEEALLSVSDSMRQ
                     ASYGLGAGKLRTVFRIVLPVAMPGILAGVILAIGRIVGETAALMYTLGTSTNTPSSLM
                     SSGRSLALHMYMLSSEGLHVNEAYATGVILIITVLMINTLSSLLSRKLVKGAS"
     gene            complement(51500..52363)
                     /gene="pstC"
                     /locus_tag="VXE25_000160"
     CDS             complement(51500..52363)
                     /gene="pstC"
                     /locus_tag="VXE25_000160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000595184.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease subunit PstC"
                     /protein_id="HEV0770697.1"
                     /translation="MIKQAFKEAVFRAIFFMSATVAVVAILLICFFIFSNGLPFMANY
                     GFARFLLGSDWSPTNIPASYGILPMIVGSLLITLGAIVIGVPTGILTSVFMVYYCPKP
                     VYGFLKSAINLMAAIPSIVYGFFGLQLLVPWIRTFLGNGMSVLTASLLLGIMILPTII
                     SLSESAIRTVPKTYYSGSLALGASHERSIFSVILPAARSGILSAVILGIGRAVGETMA
                     VILVAGNQPIIPSGLFSGTRTLTTNIVLEMAYASGQHREALIATSAVLFFLILLINAY
                     FAYLKGKSSYE"
     gene            complement(52481..53356)
                     /locus_tag="VXE25_000161"
     CDS             complement(52481..53356)
                     /locus_tag="VXE25_000161"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000669496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate-binding protein"
                     /protein_id="HEV0770698.1"
                     /translation="MKFKKMLTLAAIGLSGFGLVACGNQSAASKQSASGTIEVISREN
                     GSGTRGAFTEITGILKKDGDKKIDNTTKTAVIQNSTEGVLSAVQGNANAIGYISLGSL
                     TKSVKALEIDGVKASRDTVLDGEYPLQRPFNIVWSSNLSKLGQDFISFIHSKQGQQVV
                     TDNKFIEAKTETTEYTSQHLSGKLSVVGSTSVSSLMEKLAEAYKKENPEVTIDITSNG
                     SSAGITAVKEKTADIGMVSRELTPEEGKSLTHDAIALDGIAVVVNNDNKASQVSMAEL
                     ADVFSGKLTTWDKIK"
     gene            complement(53523..54854)
                     /locus_tag="VXE25_000162"
     CDS             complement(53523..54854)
                     /locus_tag="VXE25_000162"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000833277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component sensor histidine kinase"
                     /protein_id="HEV0770699.1"
                     /translation="MKRYLQFWLVNLSVSLILIAGMALTWISKGIGLFLLALSLGLGG
                     YWLFCLWKWEVAFETLHQPLLTSSEYFLEKGQEDLKSLAQYVSGLKTKVSQQDQQYKD
                     LAETMEVLLSHLTMGTFLVSAQGQMLLSSRSLPHYFPDVDGDISSLDDLKRMDIRNLV
                     HQAFDQKTRLKQEVSGFHEGDLILEVTAVPVFSPTQSVEAVLVLLYDLTTIRTYEKLN
                     LAFVSNASHELRTPVTSIKGFAETIKGMSAEEEALKDDFLDIIYKESLRLEHIVEHLL
                     TLSKAQQMPIQWTTLSLAEFVQDLTQSLQPQLKKKDLQLKVQVPDDVTLVSDSQLLSQ
                     ILLNLLSNAIRYTEQGGKIEVKTQKVNEGIKISVSDTGIGISQLEQDRIFERFYRVNK
                     GRSRQTGGTGLGLAIVKELSQLLGGQVTVTSQLGRGSCFTIFLPNQSFAQD"
     gene            complement(54855..55562)
                     /locus_tag="VXE25_000163"
     CDS             complement(54855..55562)
                     /locus_tag="VXE25_000163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEV0770700.1"
                     /translation="MTKQVLLVDDEEHILKLLDYHLSKEGFSTQLVTNGRKALALAET
                     EPFDFILLDIMLPQLDGMEVCKRLRAKGVKTPIMMVSAKSDEFDKVLALELGADDYLT
                     KPFSPRELLARVKAVLRRTKGEQEGDDSDNIADDSWLFGTLKVYPERHEVYKANKLLS
                     LTPKEFELLLYLMKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKA
                     PQFIRTIRGYGYKFKEL"
     gene            complement(55646..55948)
                     /locus_tag="VXE25_000164"
     CDS             complement(55646..55948)
                     /locus_tag="VXE25_000164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001823628.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupin domain-containing protein"
                     /protein_id="HEV0770701.1"
                     /translation="MTADEIWYFHAESPLTVHMITADGHYEAVTLGLDISKGQQLHYC
                     VPKGTIWGSTVDKDDALVSCLVAPGFEFEDFELFERVDLLATYPEHKEMIERLTRY"
     gene            complement(55935..56156)
                     /locus_tag="VXE25_000165"
     CDS             complement(55935..56156)
                     /locus_tag="VXE25_000165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupin domain-containing protein"
                     /protein_id="HEV0770702.1"
                     /translation="MNKSYFNPLAPTDKEDLIRTLELAPHVEGGYFRQTKKTSDTINL
                     AGKGRALYTSIYFLLRRNESFTFSPIDSR"
     gene            56118..56675
                     /locus_tag="VXE25_000166"
                     /pseudo
     CDS             56118..56675
                     /locus_tag="VXE25_000166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(56990..58681)
                     /locus_tag="VXE25_000167"
     CDS             complement(56990..58681)
                     /locus_tag="VXE25_000167"
                     /EC_number="6.1.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009729659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine--tRNA ligase"
                     /protein_id="HEV0770703.1"
                     /translation="MNTKELIASELSSIIDSLDQEAILKLLETPKNSEMGDIAFPAFS
                     LAKVERKAPQMIAAELAEKMNSQAFEKVVATGPYVNFFLDKSAISAQVLQAVTTEKEH
                     YADQNIGKQENVVIDMSSPNIAKPFSIGHLRSTVIGDSLSHIFQKIGYQTVKVNHLGD
                     WGKQFGMLIVAYKKWGDEEAVKAHPIDELLKLYVRINAEAENDPSLDEEAREWFRKLE
                     NGDEEALALWQWFRDESLVEFNRLYNELKVEFDSYNGEAFYNDKMDAVVDILSEKGLL
                     LESEGAQVVNLEKYGIEHPALIKKSDGATLYITRDLAAALYRKNEYQFAKSIYVVGQE
                     QSAHFKQLKAVLQEMGYDWSDDITHVPFGLVTKEGKKLSTRKGNVILLEPTVAEAVSR
                     AKVQIEAKNPELENKDQVAHAVGVGAIKFYDLKTDRTNGYDFDLEAMVSFEGETGPYV
                     QYAYARIQSILRKADFKPETAGNYSLNDTESWEIIKLIQDFPRIINRAADNFEPSIIA
                     KFAISLAQSFNKYYAHTRILDESPERDSRLALSYATAVVLKEALRLLGVEAPEKM"
     gene            58817..59263
                     /gene="argR"
                     /locus_tag="VXE25_000168"
     CDS             58817..59263
                     /gene="argR"
                     /locus_tag="VXE25_000168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227366.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine repressor"
                     /protein_id="HEV0770704.1"
                     /translation="MRKRDRHQLIKKMITEEKLSTQKEIQDRLEAHNVCVTQTTLSRD
                     LREIGLTKVKKNDMVYYVLVNETEKIDLVEFLSHHLEGVARAEFTLVLHTKLGEASVL
                     ANIVDVNKDEWILGTVAGANTLLVICRDQHVAKLMEDRLLDLMKDK"
     gene            59314..61848
                     /gene="mutS"
                     /locus_tag="VXE25_000169"
     CDS             59314..61848
                     /gene="mutS"
                     /locus_tag="VXE25_000169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA mismatch repair protein MutS"
                     /protein_id="HEV0770705.1"
                     /translation="MAIEKLSPGMQQYVDIKKQYPDAFLLFRMGDFYELFYEDAVNAA
                     QILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLIEQGYKVAIAEQMENPKQAVGVV
                     KREVVQVITPGTVVDSSKPDSQNNFLVAIDREGNQFGLAYMDLVTGDFYVTGLLDFTL
                     VCGEIRNLKAREVVLGYDLSEEEEQILSRQMNLVLSYEKESFEDLHLLDLRLATVEQT
                     ASSKLLQYVHRTQMRELNHLKPVIRYEIKDFLQMDYATKASLDLVENARSGKKQGSLF
                     WLLDETKTAMGMRLLRSWIHRPLIDKERIVQRQEVVQVFLDHFFERSDLTDSLKGVYD
                     IERLASRVSFGKTNPKDLLQLATTLSSVPRIRAILEGMEQPTLAYLIAQLDAIPELES
                     LISAAIAPEAPHVITDGGIIRTGFDETLDKYRCVLREGTSWIAEIEAKERENSGISTL
                     KIDYNKKDGYYFHVTNSQLGNVPAHFFRKATLKNSERFGTEELARIEGDMLEAREKSA
                     NLEYEIFMRIREEVGKYIQRLQALAQGIATVDVLQSLAVVAETQHLIRPEFGDDSQID
                     IRKGRHAVVEKVMGAQTYIPNTIQMAEDTSIQLITGPNMSGKSTYMRQLAMTAVMAQL
                     GSYVPAESAHLPIFDAIFTRIGAADDLVSGQSTFMVEMMEANNAISHATKNSLILFDE
                     LGRGTATYDGMALAQSIIEYIHEHIGAKTLFATHYHELTSLESSLQHLVNVHVATLEQ
                     DGQVTFLHKIEPGPADKSYGIHVAKIAGLPADLLARADKILTQLENQGTESPPPMRQT
                     SAVTEQISLFDRAEEHPILAELAKLDVYNMTPMQVMNVLVELKQKL"
     gene            61995..63689
                     /gene="patA"
                     /locus_tag="VXE25_000170"
     CDS             61995..63689
                     /gene="patA"
                     /locus_tag="VXE25_000170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000908145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux ABC transporter subunit PatA"
                     /protein_id="HEV0770706.1"
                     /translation="MLIQKIKTYKWQALASLLMTGLMVASSLLQPRYLQEVLGALLTG
                     KYEAIYSIGAWLIGVAVVGLVAGGLNVVLAAYIAQGVSSDLREDAFRKIQTFSYADIE
                     QFNAGNLVVRMTNDINQIQNVVMMTFQILFRLPLLFIGSFILAVQTLPSLWWVIVLMV
                     VLIFGLTAVMMGMMGPRFAKFQTLLERINAIAKENLRGVRVVKSFVQEKEQFAKFTEV
                     SDELLGQNLYIGYAFSVVEPFMMLVGYGAVFLSIWLVAGMVQSDPSVVGSIASFVNYL
                     SQIIFTIVMVGFLGNSVSRAMISMRRIREILDAEPAMTFKDIPDEELVGSLSFENVTF
                     TYPMDKEPMLKDVSFTIEPGQMVGVVGATGAGKSTLAQLIPRLFDPQEGAIKIGGKDI
                     REVSEGTLRKTVSIVLQRAILFSGTIADNLRQGKGNATLFEMERAANIAQASEFIHRM
                     EKTFESPVEERGTNFSGGQKQRMSIARGIVSNPRILIFDDSTSALDAKSERLVQEALN
                     KDLKGTTTIIIAQKISSVVHADKILVLNQGRLIGQGTHADLVANNAVYREIYETQK"
     gene            complement(64019..64282)
                     /locus_tag="VXE25_000171"
                     /pseudo
     CDS             complement(64019..64282)
                     /locus_tag="VXE25_000171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000199219.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS110 family transposase"
     gene            64480..66246
                     /gene="patB"
                     /locus_tag="VXE25_000172"
     CDS             64480..66246
                     /gene="patB"
                     /locus_tag="VXE25_000172"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000859866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux ABC transporter subunit PatB"
                     /protein_id="HEV0770707.1"
                     /translation="MKTVQFFWHYFKVYKFSFVVVILMIVLATFAQALFPVFSGQAVT
                     QLANLVQAYQNGNPELVWQSLSGIMVNLGLLVLVLFISSVIYMCLMTRVIAESTNEMR
                     KGLFGKLAQLTVSFFDRRQDGDILSHFTSDLDNILQAFNESLIQVMSNIVLYIGLILV
                     MFSRNVTLALITIASTPLAFLMLIFIVKMARKYTNLQQKEVGKLNAYMDESISGQKAV
                     IVQGIQEDMMAGFLEQNERVRKATFKGRMFSGILFPVMNGMSLINTAIVIFAGSAVLL
                     NDKSIETSTALGLIVMFAQFSQQYYQPIIQVAASWGSLQLAFTGAERIQEMFDAEEEI
                     RPEKAPTFTKLQESVEISHIDFSYLPDKPILKDVSISAPKGQMTAVVGPTGSGKTTIM
                     NLINRFYDVDAGGIYFDGKDIRGYDLDSLRSKVGIVLQDSVLFSGTIRDNIRFGVPDA
                     SQEMVEVAAKATHIHDYIESLPDKYDTLIDDDQSIFSTGQKQLISIARTLMTDPEVLI
                     LDEATSNVDTVTESKIQHAMEVVVAGRTSFVIAHRLKTILNADQIIVLKDGEVIERGN
                     HHELLKLGGFYSELYHNQFVFE"
     gene            66385..67074
                     /locus_tag="VXE25_000173"
     CDS             66385..67074
                     /locus_tag="VXE25_000173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466883.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamyl-gamma-aminobutyrate hydrolase
                     family protein"
                     /protein_id="HEV0770708.1"
                     /translation="MARTVVGVAANLCPVDAEGKIIHSSVSCRFAEIIRQVGGLPLVI
                     PVGDESVVRDYVEMIDKLILTGGQNVHPQFYGEKKTVESDDYNLVRDEFELALLKEAL
                     RQNKPIMAICRGVQLVNVAFGGTLNQEIEGHWQGLPFGTSHSIETVEGSVVAKLFGKE
                     SQVNSVHRQSIKDLAPNFRVTAIDSRDQTIEAIESIDEHRIIGLQWHPEFLVNEEDGN
                     LELFEYLLNEL"
     gene            67078..67257
                     /locus_tag="VXE25_000174"
     CDS             67078..67257
                     /locus_tag="VXE25_000174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0770709.1"
                     /translation="MEHLVVLSFIFSKFLECGILRKRLNSDKNWRNSTKKLEKNEGKR
                     YDRKEEILEEEHVTY"
     gene            67244..68593
                     /locus_tag="VXE25_000175"
     CDS             67244..68593
                     /locus_tag="VXE25_000175"
                     /EC_number="5.3.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-6-phosphate isomerase"
                     /protein_id="HEV0770710.1"
                     /translation="MSHIKFDYSKVLDKFVAPHEVEYMQSQVTAADELIRKGTGAGSD
                     FLGWLDLPEKYDREEFDRILKAAEQIKSDSDVLVVIGIGGSYLGAKAAIDFLNHHFAN
                     LQTKEERKAPQILYAGNSISSTYLADLVEYVADKDFSVNVISKSGTTTEPAIAFRVFK
                     ELLVKKYGQEEANKRIYATTDRQKGAVKVEADANGWGTFVVPDDIGGRFSVLTAVGLL
                     PIAASGADIKALMEGANAARKDYTSDKISENEAYQYAAVRNILYRKGYATEILVNYEP
                     SLQYFSEWWKQLAGESEGKDQKGIYPTSANFSTDLHSLGQFIQEGTRIMFETVVRVDK
                     PRKNVLIPTLEEDLDGLGYLQGKDVDFVNKKATDGVLLAHTDGDVPNMYVTLPEQDAF
                     TLGYTIYFFELAIALSGYLNAINPFDQPGVEAYKRNMFALLGKPGFEELSKELNARL"
     gene            68717..70177
                     /locus_tag="VXE25_000176"
     CDS             68717..70177
                     /locus_tag="VXE25_000176"
                     /EC_number="6.1.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate--tRNA ligase"
                     /protein_id="HEV0770711.1"
                     /translation="MSKDIRVRYAPSPTGLLHIGNARTALFNYLYARHHGGTFLIRIE
                     DTDRKRHVEDGERSQLENLRWLGMDWDESPESYENYRQSERLDLYQKYIDQLLAEGKA
                     YKSYVTEEELAAERERQEAAGETPRYINEYLGMSEEEKAAYIAEREAAGIIPTVRLAV
                     NESGIYKWHDMVKGDIEFEGGNIGGDWIIQKKDGYPTYNFAVAIDDHDMQISHVIRGD
                     DHIANTPKQLMVYEALGWEAPEFGHMTLIINSETGKKLSKRDTNTLQFIEDYRKKGYL
                     PEAVFNFIALLGWNPGGEDEIFSREELIKLFDENRLSKSPAAFDQKKLDWMSNDYIKN
                     ADLETIFEMAKPFLEEAGRLTDKAEKLVELYKPQMKSVDEIIPLTDLFFSDFPELTEA
                     EREVMTGETVPTVLEAFKAKLEAMTDDEFVTENIFPQIKAVQKETGIKGKNLFMPIRI
                     AVSGEMHGPELPDTIFLLGREKSIQHIENILKEISK"
     gene            70191..70625
                     /locus_tag="VXE25_000177"
     CDS             70191..70625
                     /locus_tag="VXE25_000177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine deaminase"
                     /protein_id="HEV0770712.1"
                     /translation="MDIWEKMYEEAQKLYNPHEVSDFVYANHVVAAVEAGDGQIFTGF
                     CMEGTCGVFHLCAERAALFNMYQFSGQTKVKKVLAFRDKPPYGGSSAMPCGACREFLL
                     ELNAENKDAEFMMDYNIRKTVKVSELIPYWWGEERASKFNER"
BASE COUNT        20911 a        13044 c        15210 g        21506 t
ORIGIN      
        1 agttataatt ttatatctat tagaaaataa atatgtaagg aaatttaaat gaaaaaaact
       61 acaatattat cattaactac agctgcggtt attttagcag catatgtccc taatgaacca
      121 atcctagcag atactcctag ttcggaagta atcaaagaga ctaaagttgg aagtattatt
      181 caacaaaata atatcaaata taaggttcta actgtagaag gtaacatagg aactgttcaa
      241 gtgggtaatg gagttactcc tgtagagttt gaagctggtc aagatggaaa accattcacg
      301 attcctacaa aaatcacagt aggtgataaa gtatttaccg ttactgaagt agctagtcaa
      361 gcttttagtt attatccaga tgaaacaggt agaattgtct actatcctag ctctattact
      421 atcccatcaa gcataaaaaa aatacaaaaa aaaggcttcc atggaagtaa agctaaaact
      481 attatttttg acaaaggcag tcagctggag aaaattgaag atagagcttt tgatttttct
      541 gaattagaag agattgaatt gcctgcatct ctagaatata ttggaacaag tgcattttct
      601 tttagtcaaa aattgaaaaa gctaaccttt tcctcaagtt caaaattaga attaatatca
      661 catgaggctt ttgctaattt atcaaattta gagaaactaa cattaccaaa atcggttaaa
      721 acattaggaa gtaatctatt tagactcact actagcttaa aacatgttga tgttgaagaa
      781 ggaaatgaat cgtttgcctc agttgatggt gttttgtttt caaaagataa aactcaatta
      841 atttattatc caagtcaaaa aaatgacgaa agttataaaa cgcctaagga gacaaaagaa
      901 cttgcatcat attcgtttaa taaaaattct tacttgaaaa aactcgaatt gaatgatggt
      961 ttagaaaaaa tcggtacttt tgcatttgca gatgcgatta aacttgaaga aattagctta
     1021 ccaaatagtt tagaaactat tgaacgttta gccttttacg gtaatttaga attaaaagaa
     1081 cttatattac cagataatgt taaaaatttt ggtaaacacg ttatgaacgg tttaccaaaa
     1141 ttaaaaagtt taacaattgg taataatatc aactcattgc cgtccttctt cctaagtggc
     1201 gtcttagatt cattaaagga aattcatatt aagaataaaa gtacagagtt ttctgtgaaa
     1261 aaagatacat ttgcaattcc tgaaactgtt aagttctatg taacatcaga acatataaaa
     1321 gatgttctta aatcaaattt atctactagt aatgatatca ttgttgaaaa agtagataat
     1381 ataaaacaag aaactgatgt agctaaacct aaaaagaatt ctaatcaggg agtagttggt
     1441 tgggttaaag acaaaggttt atggtattac ttaaacgaat caggttcaat ggctactggt
     1501 tgggttaaag acaaaggctt atggtattac ttaaacgaat caggttcaat ggctactggt
     1561 tgggttaaag acaaaggctt atggtattac ttaaatgaat caggttcaat ggctactggt
     1621 tggtttacag tttctggtaa atggtactat acctataatt caggagattt attagtaaac
     1681 acgactacac ccgatggcta tcgagtcaat gctaacggtg agtgggtagg ataggtatcc
     1741 attagctaaa tctaatcatt ctgaactaaa aaatcttctt acatatgtag gaagattttt
     1801 tggattctca aaactagttt aaaagactac gctatttaaa ccaattttaa gaatggatat
     1861 ataaggatat tcagaaatct agttggtcaa cttttgtatt ttgaatatac cttagatggt
     1921 gacgatgtct tggtatatct ggtactcact tacatattct aacttatttt aactaagata
     1981 caactgtagt tggtgaattt gctacaaata gtgtagaggc gttatttgaa aaatatacaa
     2041 aaaaggaacc ccaacttaca tttgagtttc tcttactttt aatcgtccga atccgtattc
     2101 ttatttcaaa aaaggtagtg aaaaatgtag tcattcgaat gatttccctt gcaatatagt
     2161 gaaattaaca aaaagaaaaa acgctgatca agcgtttttc ttctgtattg attcgtattg
     2221 aatgcttact taacttctgt aaacacaacg tgtttgcgaa gttttggtga gtatttcttc
     2281 aattgaaggc ggtctggagt gttacgtttg tttttagaag taaggtacaa gcgttcacca
     2341 gattctttgt gttcaagtgt aatatttacg cgcatggtat ctcccttcta ttattcagct
     2401 gatgcagctt tagtgatttt acgtcctttg tagtatcctt taagtgatac acggtgagaa
     2461 cgtgagtaat ctccagtagt ttcgtcaaag tttacagatg gagctgttac tttgtagtgt
     2521 gtacgacgtt tgtttttctt cgcttttgaa gtgcgacgtg caggtactgc cattttgatt
     2581 tctcctttag gtatttatat tcgattcaat ctactgattt tcatcaacca tactaggata
     2641 acacattttt tttgtaaagt aaagttactt gacaaaaaaa gatgaaaaaa ttctcctatc
     2701 cgacacggca gacaggagaa ggtgttaaat atcaatctca aatggttcgt caatggtttc
     2761 tgatacgtat tttccgtctt tcttccgttg cttgacacac tctgtgagga gatattcgat
     2821 ttgcccattg actgaacgaa agtcgtcttc tgcccatgat gcgagtgcag cgtataactt
     2881 tgttgagagt cgaaggggga tctgcttttt tttagcttca gccatcttta gtaaagactt
     2941 cctgtgttga caattggttg tgcatcatga ttgccacaaa gaacgacaag gagatttgaa
     3001 accatggcag cttttcgttc ttcgtcaagt tctaccaatt ccccttcatt gagccgtttt
     3061 agtgccattt caaccattcc tacagcacca tctacaatca tcttccgtgc atcaataatg
     3121 gcagatgctt gttggcgttg aagcataacg gcagcaattt ctggagcata agctaggtaa
     3181 gtgatacgtg cttcaaggat ttccaagcca gcatcctcaa cacgactttg gatttcttca
     3241 cgaatacggt tagcaacaat ttcgctagag ccacggagac taccttcatc tgcttgcccg
     3301 tcacccgtag tatccacatt aggagacaca tcgtaaggat agatgcggac aatattacgg
     3361 agggcgctat cacattgcag tgaaagatat tctttgtagt tatcaacgtt gaagactgcc
     3421 ttagcggtat cgacaactct ccaagttacc gcgataccga tttctacagg gtttcctaag
     3481 caatcattga ttttttgacg agaattgctc aaggtcatga ctttgaggga aatgtgtttc
     3541 ttgccaattt caagatttac atcattgtca tttgatgatt tagctcctaa aaaaggagat
     3601 tttgtgctaa catcaccact ttgtccaagt cgagtgtggt ttgcagggtt gactgctacg
     3661 ctgaagggat tgacaaagta aaaaccaggt tctttgatgg tacctgtata attaccaaag
     3721 agtgtcagaa ccagagcttc ctgaggtttg acaactttta aaccagcatg agctagacct
     3781 gcaattacga ttagtaaagg tccgataata attccaaaaa tgttttccga accaaccccc
     3841 attataaata taaagatacc aagtacgatt gtcaactcaa tgagaatcaa tgcgaataca
     3901 ccatttggtt ttgaattgat tagtttttca gtcataagaa tgacctccca ttatttgata
     3961 tctaaatgat atcactttgt ttttaaaagt caatagaaag ttgaaaataa tcactaaaaa
     4021 gtttcagccc aataatttct tttaaaaggt gagattatat tgtgctcaaa tactctttta
     4081 ttcttataat ttttacacta taattgtagt tagaaaggaa gagaaatgtt tgattataga
     4141 gcactagtta ttttgatgac tttgatggat cattgtgagc tatcattata tgaattatct
     4201 gttaaggtga gcttacctat aaaggaagtc aaagaaggaa tagattattt agtgccttat
     4261 ctagctaata aagggatagt gctggataaa aagcaaggtc gctatagttt atcaaatcgt
     4321 acgaagcagt ctttgacaga tattattaag tcggatgaat tggttttacc aaagtcgact
     4381 cgcttagctt taatctatct ttacactttt tgccgattag attttatatc gaatagtcat
     4441 taccaagact ttttgaaagt aagtaagaat acaaccttat ctgatattca atcattaaga
     4501 aagattatgt tagataatga tttggagcta gggtacagta gagcaaaagg ttatacttta
     4561 cacggttcag agtggaataa gcaccgctta gcttttcaaa tggttagtga gttgctggaa
     4621 tcctccatag ggatttgggg tttggattat gttttatcca gttgggggta ttcattaact
     4681 tatgatttga ttgatcaggt agttaaagat tattatgaga agctacagct agtacctatt
     4741 gttaatcaat taaaagttta ccttttcggt ttagtattca ttctgtgtag gtatcaaagg
     4801 gatgttgaaa gagtatgtct ttcagagaca ttagtatctc ctgttattca agatataacc
     4861 actattttat tggatacagt ggttgatttg ggaattatag atacggtgtt ttctgaggat
     4921 gattatcgct atatcaccgt tttattatca agttgctttg aaggtgaagt agatgttgct
     4981 ccggtttact ttaatcaatt aacagaggct attataagta gaatggaaga tatttctttg
     5041 ttacatttta aacaaaggga aggattgaga gaaaatcttc gccgccacct tataccggct
     5101 tactatagat taaagttcgg cctacctagt tcaaatgaat atgtattgca tgttaaagaa
     5161 cattatcctg atttatttga attagtcaaa gattctttga tgcccttgat ggacgctatt
     5221 gacaatccca tacctgatag tgaaacagca tattttgtta tccatttcgg aggttattta
     5281 aagaaagcag atactttgcc tcaaaaatgg tataaagcag caatcatttg tcctaatggt
     5341 gttagttctt cattgatgtt aaaagagaat ctattagcat tatttcctca aattgagttt
     5401 ataggaacct caaagattga tgatttacag gtgaaagcta gtagtgacta tgatatggtt
     5461 ttttctacca taaaggtgga gacagaaaag ccaaattatc tagtttcggt tatgatgact
     5521 gaagagcaag caatacaact agtagaacta gtgttaaaag attttccgaa tttagagtat
     5581 ggagattttg agattgaaca aatcctgaat attgtcaaaa gatatggaat tattacacaa
     5641 gaattggaat taagattggc gttaaagaat tatctttacc aaaaaaatga tagaaaggaa
     5701 attgtaccag tgctagaaca acttattacc aaagaaacct atcaggttag ttcgcaaaaa
     5761 ttaggatgga aggaggcgat tcgtttagca gctaaaccgc ttttggatca agataagata
     5821 actgagaact accctgaggc aatgattcaa aaagtagaag agtttggacc ttttattaat
     5881 ttagggaagg gagtagcaat tcctcacgct cggccagatg aaggtgtgaa tgaaatagga
     5941 atgtcaatgt tagttttgga agaaccgatt tatttattgg ataatccaga acaagaggta
     6001 agattgttga tttgtattgc agccattgat aatgagagtc atttaaaggc tttgtcacat
     6061 ttaacaacaa ttttaagaga taaaaatcat gttcaaactt taatatcatc aaaaaactat
     6121 aatgatatta aaatgataat taaacaggag gattagataa tgttaaaaat tggtacagct
     6181 tgtggttcag gattaggttc aagttttatg gtacagatga atattgaatc tgtattgagt
     6241 gatttgaatg tttcggatgt agaagttgaa cattatgatt taggtggagc agatccaaat
     6301 gcagctgata tttggattgt tggtcgtgat ctagctgatt cagctagtca tcttggagat
     6361 gttcgtatct taaatagtat tattgatatg gatgaactac gagaattaat tactaaactt
     6421 tgtgaagaaa aaggacttat ataggaggct agcgtcatga tgaagttcat attggatatt
     6481 gttagtacac cagctatttt agtagcttta attgcaattt taggattagt tcttcagaag
     6541 aagaaattac ctgatattat taaaggtgga attaagacct ttgttggttt cttagttgta
     6601 tctggtggtg caggaattgt acaaaattct ttaaatccat ttggtaccat gtttgagcat
     6661 gcttttcatt tatctggcgt tgtgccgaat aatgaagcaa ttgtagctgt agctttaaca
     6721 acatatggct cagctactgc aatgattatg tttgcaggaa tggtgttcaa tatcttaatc
     6781 gctcgtttta ctcgatttaa atatattttt ttaacagggc accacactct atatatggca
     6841 tgtatgattg cggtcatttt atcagttgct ggctttacta gcttgcctct catcttacta
     6901 ggaggattag cactcggtat tattatgagt atttccccag catttgtgca aaaatatatg
     6961 gttcaattaa ctggaaatga caaggtggct ttaggtcatt tcagttcttt gggatattgg
     7021 ttgagtggtt ttactggtag ccttatcggt gacaaatcaa aatcaacaga ggacattaaa
     7081 tttccaaaga gtttagcttt tttacgtgat agtactgtta gtatcacttt atctatggca
     7141 gttatttaca ttattgtagc tatctttgca gggtcagaat atatagaaaa agaaatcagt
     7201 agtggtacaa gtggtctagt ttatgcttta caattagcag gtcaatttgc agcaggggta
     7261 tttgttattt tagcaggtgt tcgccttatt ttgggcgaaa ttgttccagc ctttaaaggt
     7321 atttcagagc gtcttgtacc taattcaaaa cctgctttgg attgtccgat tgtttatact
     7381 tatgcaccta atgcagttct aattggattt atctctagtt ttattggtgg tttagtaagt
     7441 atggcaatta tgattgcttc aggaacggtt gttatcttac caggcgttgt gcctcatttc
     7501 ttctgtggag cgactgcagg tgttattggg aatgcatctg gtggtgttcg tggagccact
     7561 attggagcat ttttacaagg tattttaatc agttttctcc cagtcttttt aatgccagtt
     7621 ttgggaggac tcggtttcca aggatcaact ttctcagatg cagattttgg tctatcagga
     7681 attattttag gaatgttaaa tcaatttggc tcacaagcag gcattgtgat tggtcttgtt
     7741 cttattttag cagttatgtt tggagtatcc tttattaaaa agccatctgc aaaggaggaa
     7801 taagggatga ttttaagtaa aaatagagaa gatgagttaa gaaaatttgc gactaacatc
     7861 cgattaaata ctcttagaac attgaatcat cttggattcg gacattacgg aggaagtctg
     7921 tctatcgtag aagttttagc agtgctttat ggtgaaataa tgccaatgac tccagaaata
     7981 tttgcagcac gagatagaga ttatttcata ttatcaaaag gtcatggagg accagctcta
     8041 tacagtacac tctatttgaa tggtttcttt gacaaagaat tcttatattc tttaaataca
     8101 aatggaacca aattaccgtc tcatcctgat agaaatctaa cgccaggcat agatatgaca
     8161 acgggctctt taggacaagg aattagtgtt gcaactggac ttgcatatgg tcagagaata
     8221 agaaagagtc ccttttatac ttatgctatt gttggagatg gtgagttaaa tgaaggacaa
     8281 tgttgggagg ctatacagtt tgcttctcat caacagttat ccaacttaat tgtatttgtt
     8341 gatgagaaca aaaaacaatt agatggtttt acaaaggata tttgtaatcc aggtgatttc
     8401 gtagaaaaat tttcagcatt tggatttgaa tccattaggg tcaagggttc agatattaga
     8461 gaaatttatg aagggattgt ccaattaaaa cagtcaaata attcatcacc taagtgcatt
     8521 gtattagata ctattaaagg tcaaggggtt caagagctgg aagaaatgaa atccaatcat
     8581 catcttcgcc ctactgtaga ggagaaacaa atgttaactt cagttgtaga aagattaagt
     8641 caggaattgg aggaaacaga atgatgagaa gtacgaaaga attacggcat gtatatagag
     8701 acttcctttt agaggctaat caaagtgatt ctgatatagt agtcttagaa gccgatttgt
     8761 caagttcgat ggctactcat aatcttgaaa aggactttgg agaccgttat gtgaatgttg
     8821 ggattatgga agcagaaatg gtcggccttg cagcaggctt gtctattcag gggtttagac
     8881 cttatcttca tacatttggt ccttttgctt cacgaagagt atttgatcaa ttatttattt
     8941 ctcttggata cgcacaattg gatgccactg tgattggatc agatgcagga gtaactgcag
     9001 aaatgaatgg tgggacacat atgccatttg aagaaattgg attgttacgt ttaattccta
     9061 aatcgatcat ttttgaagca actgatgata ttcaatttcg tgaaatattg aaccagacat
     9121 tagacttaaa aggactaaaa tatattcgaa caattagaaa agctccagtt cctgtgtatc
     9181 aaggtggaga agatttttct aaaggctaca ttgagttaag acacggggaa gatcttgtaa
     9241 tcgttgcttc tggtataatg gttgctccaa gtattcgagt tgcagatgaa ctgtctaaat
     9301 taggttactc agtaggtgtg atagatttat ttagaatcaa accgatacca gaacagataa
     9361 aaacaatgtt aagtggaaaa actatattta ctgtagaaaa ccacaatcag ataggtggaa
     9421 ttggcagtgc tttatgtgaa ttattctctg atgatggaat aacaaaaatt catcggatgg
     9481 gggttcaaga aagattcggt caagtaggga aaatggatta tcttcttaat gagtatggtt
     9541 tgagtgaatc gaatataaaa gagaaggttc tagaaattta taatgcaaga tagatgttaa
     9601 atacacttat ctgaaagaat ttctgtaaaa attacattac gttatttaaa gaaagcggat
     9661 taaaaagcat attctggtca tcagaaagtg cactaatccg ctttgttgtt tttaatttta
     9721 aatatttcac atgcgtatag aattttctga aaattcaaga attttattct gttcattgcc
     9781 tttaaattgt gctataatag taaaaactga aatgggaggg ataagatgac tgaattagat
     9841 aaacgtcacc gcagtagcat ctatgacagc atggttaaat cacctaaccg tgctatgctt
     9901 cgtgcgactg gtatgacaga taaggacttt gaaacaccga ttgtgggagt gatttcgact
     9961 tgggcggaaa atacaccatg taacattcac ttgcatgatt tcgggaaact ggctaaagaa
    10021 ggtgtcaaat ctgcaggcgc ttggcctgta cagtttggaa ccattaccgt agcggacggg
    10081 atcgctatgg gaacacctgg tatgcgtttc tctctaacat ctcgtgacat catcgcggac
    10141 tccatcgagg cggctatgag tggtcacaac gtggatgcct tcgtcgctat cggtggctgt
    10201 gacaagaaca tgcctggatc tatgattgct attgctaata tggatatccc agccattttc
    10261 gcctatggtg gaactattgc accgggaaat cttgatggta aagatatcga cttggtttct
    10321 gtctttgaag gtatcggaaa atggaaccac ggtgatatga cagctgagga cgtgaaacgt
    10381 cttgaatgta atgcctgccc tggccctggt ggttgtggtg gtatgtatac tgctaatacc
    10441 atggcaactg ctatcgaagt tctagggatg agtttgccag ggtcatcctc tcacccagct
    10501 gaatcagctg ataagaaaga agatatcgaa gcagcaggac gtgctgttgt taagatgttg
    10561 gaacttggtc tcaaaccatc agatatcttg actcgtgaag cctttgaaga tgctatcact
    10621 gtaacgatgg ctctcggtgg ttctacaaac gccactcttc acttgctcgc cattgcccat
    10681 gccgcaaatg ttgacttgtc acttgaggac ttcaatacga ttcaagaacg tgtgcctcac
    10741 ttggccgact tgaaaccatc tggtcagtat gtcttccaag acctctacga agtcggtggt
    10801 gtccctgcgg ttatgaagta tttgttggca aatggtttcc ttcacggaga tcgcatcaca
    10861 tgtactggta agactgtagc tgaaaacttg gctgactttg cagacttgac tccaggccaa
    10921 aaagttatca tgccacttga aaatccaaaa cgtgcggatg gtccgcttat catcttgaac
    10981 gggaaccttg ctcctgacgg tgcagttgcc aaggtatcag gtgttaaagt gcgtcgtcac
    11041 gttgggccag ctaaggtctt tgactcagaa gaagatgcga ttcaggccgt tctgacagat
    11101 gaaatcgttg atggcgatgt agtcgttgtt cgttttgttg gacctaaagg tggtcctggt
    11161 atgcctgaga tgctgtcact ttcttcaatg attgttggta aaggtcaggg agataaggtg
    11221 gccctcttga cggacggacg tttctctggt ggtacttatg gtctggttgt tggacatatc
    11281 gctcctgaag ctcaggatgg tggaccaatt gcctatctcc gtaccggcga tatcgttacg
    11341 gttgaccaag ataccaaaga aatttccatg gccgtatccg aagaagaact tgaaaaacgc
    11401 aaggcagaaa caaccttgcc accactttac agccgtggtg tcctcggtaa atatgcccac
    11461 atcgtatcat ctgcttcacg cggagccgtg acagacttct ggaatatgga caagtcaggt
    11521 aaaaaataaa ctcatactcg aaaatctctt caaatcacgt caacgtcgcc ttgccgtagg
    11581 tatggttact gacttcgtca gttctatcca taacttcaaa acagtgtttt gagcaacctg
    11641 cggctagttt tctagtttgc cctttgattt tcattgagta tcaaaaagca agccattttc
    11701 ggcttgcttt tttcatcttt aaaagtgatt ggcctgctta acgaggtggt agtccaaggg
    11761 caatacggcc atagcgactg attcgtgtga ttttccaagc aggcgaccag gtaacttcaa
    11821 ccttgatatc tttgataccc tcgatttgtt tcagacctgc cacaatttca ataggcaggc
    11881 tttcggcgca atcacaggca gtatcggtga aggtcatgac aatcttgcag agccccgttt
    11941 catccagatt gatttcataa atcagaccta gattgtaaac atccaattcc acatctgtat
    12001 caaaaacttt ctctagtttt tcgataattt ggtcttgcaa ggccaaagca cggtcattga
    12061 ttttgatatc gtctctcata gcagtccctc cacgtgataa atatcctcta ttttctcata
    12121 attctgacaa tttggcaagt ttttgatgaa ttttctgaaa aatatgataa aatgaagaaa
    12181 atacggaatc aaggggaagt ctatggagca gattggaaaa gtctttagac aattacgaga
    12241 gtcaagaaat atctcactga gacaagcaac cggaggacaa ttttcgccgt ctatgttgtc
    12301 ccgttttgaa acaggtcaga gtgagctttc ggtggaaaag tttctatttg ctctggaaaa
    12361 tatatctgcc agtgtggagg agatcctctt tctggcgaga ggtttccagt atgatacaga
    12421 ttctgagttg agaaaagaaa ttacagatgt cttggaacca aagaatatag cacctcttga
    12481 ggacttatat cgcagggagt atcaaaagca tgcccattct cacaacaaac agaaacatat
    12541 tctaaatgcc attattatca agtcttatat gaagagcatg gatgaaaggg tagagttaac
    12601 agcagaggaa ggaaaagtcc ttcatgatta tttgttttct accgagatct ggggaatcta
    12661 tgaactcaat ttattttcag tcagttctcc atttttatct gtttctcttt ttactagata
    12721 tgtacgagaa atggtacgta aatctgattt tctaatggaa atgtctggca atcgaaacct
    12781 ttttcatact atactattga atggcttttt agctagtatt gagtgtgaag aatttaccaa
    12841 tgcctattat tttaaacgtg ttatcgaaga gcatttctac aaggaaaatg agacctattt
    12901 ccgaattgtt tatctgtggg cagaaggtct ccttgatagc aagcaaggta gagtcaagga
    12961 aggccagaaa aagatggagg atgctgtccg tatttttgag atgcttggct gtaataaatc
    13021 tgccgaatac tatagaaata cgactgaatg ttgaatatct gcaaaccaag aaaaaatttg
    13081 aagcgataga actattgccc tctctcaggt cattacaaaa gttctatcgt ttctttttgc
    13141 tcattttatt tgttgcatat attcaagagt tctccctctc aaatttctaa gtgctatact
    13201 atagtcatac ttcatataga ggttcgaaca agaagggaga ttatctatga aactattgtt
    13261 tagaaatcca gcttatagaa ttttgatttt atcacgcttc ttcaatgctt ttggtgcttc
    13321 gattttcaac ctggtcttta tcgtctatgc atcgaccttg tcacaagcat cttttgctgt
    13381 tgctatggcg aatattgtca tgattcttcc gaccctcttt acagtttttg tagggattcg
    13441 ggcagattac acgagggaca aggtcaaatg gatggtctat agcggtttgt ttcaggcggt
    13501 tctatttttt ctagcagccc tagttgttca gcaagctagt ctctttgcct tttctagcct
    13561 gtgtttgatc aatgtcatta gtgatatcat cagtgatttt gcaggtggcc tgcgtatgcc
    13621 tcttattaag gaaaaagtag ctgaagatga tttgatggag gcttattctt tttcacagtt
    13681 catcacctat atttcagcta ttggtggtca agctttcgga gtctggctct tagctctatc
    13741 ggtcaacaat ttttctctcg ttgcgggaat caatgcctgc tttttcctag tatcagccac
    13801 tatcctcttt ttaggaaaaa gcaaattgag cctgtcaatg tcatctgctg atggtgaaaa
    13861 cttaaaaaat gagaagcttt ctatcaaaga ccagttccta acaatttacc gaaatttacg
    13921 tctcgttttt cttaaaagtg gacagaaaaa ctttggtttt atgctctttg ctgtcttgct
    13981 tattaattcc ttgggtggcg ctttgggtgg aatttataat atcttctttt tgagccattc
    14041 tctcttgaat ttttcttata cagaggcact atttatcaat caattctgtg ttttagtagc
    14101 aatcatcatc agtagcctta cgggcaatgc ttattttggg aagcagtcct tgcctagatt
    14161 gatgatgtgg gcgaccgtag gacttagtct agttggtttg gctaatttat tcaatcaagt
    14221 cgtgcttggt ttgctatttc tcttctttac tctgtatgtg tctggtaaag ttcaaccaaa
    14281 gattagtgcc atgctcatga aaaatctagc tccagaggtt ctagctcgta ctagtaattt
    14341 tttaggtcta ttgtttacct tatccatacc tgtgggaaca gcttgttttt cactagtagc
    14401 cgtatggaac atgcagttga cttggatgct atttgttggt ctttccttgc tagctatttt
    14461 tttaacaatt cttaatctca aaaatgatat ctaaatccta atttttttct tactgtttta
    14521 atccctctat ttatggtaaa ataagactat taagtttaaa gaggattccc tatgaaatta
    14581 caaaaaccaa aaggaacgca ggatatttta cctgctgagt ctgctaagtg gcagtacgtt
    14641 gagggctttg cccgtgagat tttcaagcgc tataactatg cagaagtgcg cacgcctatt
    14701 tttgagcatt acgaggttat cagccgctct gtcggagata caacggatat cgtaaccaag
    14761 gaaatgtacg atttttatga caagggtgac cgtcatatta ccctccgtcc agaaggaact
    14821 gcgcccgttg tccgttccta tgtggaaaat aaactcttcg ccccagaagt gcaaaagcca
    14881 agcaagttct actatatggg acctatgttc cgttatgagc gtccacaggc agggcgcttg
    14941 cgccaattcc accagattgg tgttgagtgt tttggctcta gcaatccagc taccgatgtg
    15001 gaaacaatcg ttatggcagc ccattttttg aaggaaatcg gtattcaagg tgtcaaattg
    15061 cacctcaaca ctcttggaaa tcctgagagc cgtgcagcct accgccaagc cttgattgac
    15121 tatttgacac cgctcaagga gaccttgtct aaggatagcc aacgtcgctt ggaggaaaat
    15181 cctcttcgtg tcttggactc taaggaaaaa gaagacaagg tggcagtaga gaatgcgccg
    15241 tctatcttgg actttcttga tgaagaaagc caagctcatt ttgatgctgt gcgtcagatg
    15301 ttggaaaatc ttggagtaga ttacatcatc gataccaata tggtgcgtgg tctggactac
    15361 tacaaccaca ccattttcga gtttatcaca gagattgagg gcaatgactt gacagtctgt
    15421 gcgggtggtc gctacgatgg tttggttgct tactttggag gccctgaaac tgctggattt
    15481 ggttttgggc ttggtgtaga gcgtctgctt ctcatccttg aaaaacaagg cgtggccctc
    15541 cctatcgaaa atgccttaga tgtctatatc gcagtcttgg gtgatggagc aaatgtcaaa
    15601 gccctagaac tagtccaagc ccttcgccaa caaggtttca aagcagagcg tgattacctc
    15661 aaccgtaagc tcaaagctca gttcaagtca gccgatgtct ttgcgactaa gaccctcatc
    15721 accctgggag agagcgaagt cgaaagcgga caagtgacgg tcaagaacaa ccaaacccga
    15781 gaagaagtgc aagtgtcact tgagacaatc agccaaaact tttcagaaat ctttgaaaaa
    15841 ctaggatttt atactcaata aaaatcaaag agcaaactag gaagctagcc gcagattgct
    15901 caaaacactg ttttgaagtt atggatagaa ctgacgaagt cagctcaaaa catggttttg
    15961 aggttgtaga tgaaactgac gaagtcagta accataccta cggcaaggtg aagctgacgt
    16021 ggtttgaaga gattttagaa gagtattaat gatagataaa gtggtcagga acttactcct
    16081 gacctttttc ttttgcaaaa tgacaaaaat cataaacttt ttgacaacta taattgtcaa
    16141 aaagaaaaag atatgttaca atgaattcaa gttaagaaat aggaagcaga aaggagttat
    16201 aatgtgggta ctaggattta tactatttat gattttcttt tattctaata attctaaaaa
    16261 aatcaagaaa ctagagaata aaatcaaaaa acttgagcga aaagagaaag gaaacgcaga
    16321 aatgtcgaga ttattacaag aaatgattgg aaaggaacca attataacgg gagtgtatat
    16381 tgggccagat aactgggaag ttgtggatgt tgatgaggaa tgggtcaaac tacgtagtgt
    16441 tgataatacg ggaaaagaaa aattcaagtt gcaacgtatt gaagatatcc aaaccgttga
    16501 atttgacgga gagtaggtgt gtaacgtgca actaaaaaat cgtctaaaag agcttcgagc
    16561 tcgcgatggt ctcaatcaaa ccgacctagc caaactggca ggggtttcca gacagaccat
    16621 tagcctacta gaacgggatg agtacacccc atccattatc attgccctga aaatatctca
    16681 aattttcaac gaaacagtcg aatcggtatt tcgtttggag gaggacgagt gatgaacaag
    16741 tataaagtga tttattatgt agtggtcata gctttattag tcagcgtatt tctactgatt
    16801 gggatggacc taagctggtt taatccctat caaagcgacc aatttgtttg ggtctacttt
    16861 gctctcatcc cagtaactga atggattgaa aagaaatcca aaaatctagc aagtgaaaaa
    16921 ggagaatgaa tatgaaaaag aaacgtagat tgttattttt gatgtctatt gtcttggggg
    16981 ggttcttggg catgtttgta gggatgttta aggcacgtgt cgaatcccac gaaattattt
    17041 tagatgtaaa agccttgatg ccatggatat cagctatttg tttactgata ggtttcatta
    17101 gtatgttttt gactttcaat ttcttaaaga aaagcagaaa atttcattcc ttgtatcaag
    17161 aggaaatgga tgacgatctg aatgaaacct attatgtgca aatgtatcgg aatcttgagt
    17221 ttggaaccat tgcttttaat attataggtg tagcgattcc attggctatt tttatttcat
    17281 taagtgaggt gattatattg catacaaacc ctcaaacatt tttcctttct ttcttactct
    17341 ttgtggtatt cttagtcgct caaaaatctc tttttaaaac cattgcgatt gttcgtcagt
    17401 ttgatttgga atttttcgct acaccaaagg atgtcttgaa ctatataaat tcttatgatg
    17461 aaggggagcg tcaggctaat ttggaacaga gttttcgaat tttattccaa ttacaccaat
    17521 atgtcttacc agccttatat atttttctta ttatcatttc tttcttgaca ggagagattc
    17581 agttactagc tttcttgctt gtaggagcca tccatgttta tatcaatgtg atgcagttac
    17641 ctatggtaaa acgttatttc aaataaagga gttatctatg aaattactta aaaaccttgg
    17701 ctggattctt ctagcccttc tatccttttt atttatctat ggctttattc aggggctcgc
    17761 gactgcgtcg cttgctttag gcgcttcacc ctatgctgtt actctactct atgtggcctt
    17821 ggctggagta tatgtgtacg gcatttacaa atggtatcag aaggctcctg ttcatattga
    17881 gaagagcggc tttaatcgat ttatttggct tcctgtcttg gtttggttct tatctctggt
    17941 cgttcaattc ttcttgccag atgatccttc agtaaatcag caaatagcga cagacttgac
    18001 cttgtctcaa ccacttttct cattctttgc tgtggttatt tttgctcctt tgacggaaga
    18061 gattgttttt agagggatgt tagcacgcta tctctttcct aagcaggaca atagtaaacg
    18121 aaccctgatt tttcttctgg tatctagtct tctatttgcc ttgattcatt ttccaggtga
    18181 tgtgcaacaa ttttttgtct attttagcct tggttttagt ttgggtttgg cttacgttag
    18241 cagaaaaggt ctggtctaca gtatttctct tcacgctttg aataatttag tcggcttttt
    18301 gatgattctc atgctataat agagtcagga ggtcacatga aacgagtaat tttattagca
    18361 gtgattcagg cagtcgttct atttttcatc attggagcgc tagcttatgc cttcaaaggc
    18421 gatttcttct ataactatct agcagttgtc tttgctccta ttgcaggtgt actgcgtttt
    18481 gggacggctt acataacgga aattgtcttg cctcgaaagg cagccgaaat cgctgaaaag
    18541 cgtaaagcag gcaaaaattc aaaataaaag agtccggtga agttcatcgg atttttgtat
    18601 tatactcaat gaaaatcaaa gagcaaacta ggaagctagc cgcaggttgc tcaaaacact
    18661 gttttgaggt tgtggataga actgacgaag tcagctcaaa acatggtttt gaggttgtag
    18721 atgaaactga cgaagtcagt aaccatacct acggtaaggc gacgctgacg tggcttgaag
    18781 agattttcga agagtattag cgctaatttt tagggctttc acctgacttt taaagactgg
    18841 caaacttttc tgatgatttt catgaagagc ctgcgctttt atggtaaaat agtaacagaa
    18901 taaaagagga gagaaataat gaaacgtagt atgtatgctg gtcgtgttcg tgaggaacac
    18961 atcggacaag aaataacctt gaaaggatgg gttggccgtc gtcgtgacct tggtggtttg
    19021 atctttatcg atcttcgtga ccgtgaagga atcatgcagt tggttatcaa ccctgaaaaa
    19081 gtatctgcag aggttatggc aacagctgaa agccttcgta gcgaatttgt tattgaggtg
    19141 actggtcagg tcgctgcgcg tgagcaagcc aatgataagt tgccaactgg tgcggttgag
    19201 ttaaacgtga cagctcttat tgtgcttaac acagctaaga caacaccatt tgagattaag
    19261 gatggcattg aggcaaatga cgatacacgt ttgcgttacc gttaccttga ccttcgtcgt
    19321 ccagaaatgt tggaaaatct taaacttcgt gccaaggtga cccactctat ccgcaactac
    19381 ttggatgagt tggagtttat cgacgtggag acaccattcc tttctaagtc aacgcctgaa
    19441 ggggcgcgtg attatttagt gccgtctcgt gttaataagg ggcattttta cgctcttcct
    19501 caaagtccac aaatcacgaa acagctcttg atgaatgctg gttttgaccg ttactaccaa
    19561 atcgttaaat gtttccgtga cgaggacttg cgtggagacc gccagcctga atttactcag
    19621 gtcgacttgg aaacgtcctt ccttactgag caagaaatcc aagatattac agaaagcttg
    19681 atcgcgcgcg tgatgaagga aacaaaaggc atcgaagtaa cgctaccatt ccctcgtatg
    19741 aaatacgatg atgctatggc tctttacggt tctgacaagc cagatactcg ttttgacatg
    19801 ttgcttcagg acttgacaga agtggtccga ggtgtagact ttaaagtctt ttcagaagca
    19861 cctgctgtaa aagcgattgt ggtcacagga gctgcggaca actattcacg taaagacatc
    19921 gacaagatga cggaagtagc caaacagtat ggtgccaaag gtcttgcttg ggtcaaggtg
    19981 gttgatggag aattaaacgg accagttgcc aagttcttga ctggtatcca agaagaattg
    20041 acaacagcgc ttgttcttga agataaggac ttggttctct ttgtggcgga tacgcttgaa
    20101 gtggctaatg caacactggg tgcccttcgt ggacgtattg ctaaagagct tggcttgatt
    20161 gataatgata agttcaactt cctttgggtg gttgactggc cgatgtttga atggtctgaa
    20221 gaagaaggcc gctacatgag cgcccaccat cctttcacac ttccacagga agagactgct
    20281 catgaattag aaggtgattt ggctaaggtt cgtgccattg cttacgatat cgtcttgaac
    20341 ggttatgagc ttggtggtgg tagccttcgt atcaaccaaa aagaccttca agaacgcatg
    20401 ttcaaggctc ttggtttctc aactgaagaa gccaatgacc agtttggttt ccttcttgaa
    20461 gccatggact atggtttccc accacacggt ggtttggcta tcgggcttga ccgttttgtc
    20521 atgttgcttg ctggagaaga aaatatccgt gaagtcattg cctttcctaa gaacaacaag
    20581 gcaactgacc caatgacaca agctccatca acagtcgctc tcaaacaact agaggaactc
    20641 agcttacaag tagaagaaga tgaaacaaac aaaacgaatt aagcggtggc gctattatct
    20701 gcgccgcttt gcttatcaga taaaaatttt acgtgtctta caaagtatct ctcgagaaaa
    20761 gtatgatgag aagatttcgg cctctctggt ctatggtttt ttatcagcag tagcagttaa
    20821 tttctttttc caaccagggc atgtgtattc gagtggtgca acaggtctgg cacagattat
    20881 ctctgccttg agtaatcact ggtttggttt tcatattccg atttcgctaa ccttctacgc
    20941 cattaacttc cctttgatgg tcttagcttg gtatcagatt ggccataagt tcaccgtctt
    21001 tacctttatc acggtatcta tgagttcctt ctttatccag tttgtccctg tggcaacctt
    21061 gacggaggat cccattatca atgccctttt tgggggtgtt gttatgggtt tggggattgg
    21121 ttttgctctt cgaaacaata tctccagtgg tgggacggat atcgtcagcc tgactattcg
    21181 caagaaaacg ggtaagaatg ttggtagtat ttctttcttg gtaaatggaa ctatcatgct
    21241 gatagcaggt ttgacctttg gttggaaata cgctctttat tctatgatta ccatctttgt
    21301 ctctagccgt gtgacagacg cagtctttac taagcaaaag cgtatgcagg ccatgattgt
    21361 gacaaatcat ccagagaagg taattgaaaa aatccataaa aaattgcacc gcggagcaac
    21421 catgatccat gatgcagaag gaacctataa tcacgagaga aaggcagttt taatcactgt
    21481 cattacacgt gcagagttta atgaatttaa acagattatg acacaagtgg atccaagctc
    21541 ctttgtctct gtctcggaaa atgttcatat tctaggaaga tttgttgaga tagataatta
    21601 gtgattaata ctcttcgaaa atctcttcaa accacgtcag cgtcgcctta ccgtatgtat
    21661 gttactgact tcgtcagttc tatctgcaac ctcaaaacca tgttttgagc tgacttcgtc
    21721 agtttcatct acaacctcaa aaccatgttt tgagctgact ccgtcagttt catctacaac
    21781 ctcaaaacca tgttttgagc tgacttcgtc agttctatcc acaacctcaa aacagtgttt
    21841 tgagcaacct gtggctagct tcctagtttg cactttgatt ttcattgagt ataaaaagat
    21901 cttgggtaac aactcaattt cagtagaaaa ggaagtaaat cttcccacaa taaaacgcat
    21961 agtatcaagt tttttcaata cctgatagta tgcgtttttg cttttaacga ctttttgccc
    22021 agtctcttat ttttcgataa ttttgtgggc gatcaattga cggtaacaaa tttgtttatt
    22081 gtttttatta tcattaataa tctggagaat agtttcaagg gaaacacgac caagctctaa
    22141 actattgata tcgacatagg ctgccaagtt gagcttggga ttaaccgagt caaagctgag
    22201 aacagggaca tccagctggt gtttggcaat atagttacaa acaccttcag ctaggaggct
    22261 atcggttgtg atgatagcat caatttgtgg atcgtgcttg aataatcgct tgctaaattt
    22321 atagcccttt tcttccagaa actcgtcggc aaagtagatg cgattgttgt cagtggtaag
    22381 tttgtaatgt ttaagcgcct gttcatagcc tgttaaacgg tctttggtca cgaagagctt
    22441 tttacttcct ccgataaagg caatgcgttt gcagcctttt ttgatgaaat attcagtcgc
    22501 atcaaaacca gcttgaacat tgtcgttgtc gacaagtggg atgaaaggag atagagattt
    22561 acctaagata aggaagggga actgttcttc tgcgacgagt tttacgagag ggtcttcttc
    22621 ttgggcatag agaaagatta gcccatctac acgcttgccg tagaccattt gtgaaatagc
    22681 gttgagacgc tccttctcat ctttccctgt tgctatctga atggcatagt ggttttcaga
    22741 tgcgacttga gagatgccac gtagaaccga tggaaagaaa ggattctggt agaaggcgtc
    22801 tgagtcatca ggaagaacta atccgataac ctgagtatag ctgcttacca agctacgagc
    22861 gttgaggttt gggtggtagt tgagttcctt catagctttg cgaacgcgtt tttttgtttc
    22921 gtcgctaatg gttgatttat tttgaataac acgggttacg gttgaaggcg aaacaccagc
    22981 agccttggcc acgtctttaa tcgtaacggg cataaaaatc tcctatttat ggtaatttgg
    23041 atcacggaaa tgtgttttat aaaagatagt gaccagatac agaacaaaaa gaatattttg
    23101 tacagtaatc agggttgtca tattttggcc aaataatccc aaaataagtg taatcagagt
    23161 cggcaatcct aaacagttca agataaagtg atagcactct ttaaaggttc taaatgaaaa
    23221 gaggcgtgat ttcttagtga tataaaggag aagactagct cctagagaga cgataaagaa
    23281 attcaaacca aagaggaagc tcgcaccgag aactaggaag aggctgatat agacacgatt
    23341 ttgttggtac cagtctttag aaattgcttg ggtcaagctg tctttgcttt tgaaactctc
    23401 agtctgaatg gctcggtaag agatgcgggt cagttccttg ctttccttgc tgatgactag
    23461 ctcatttgta tcgaaatgca gttgcaagtc cttaggtaat tccttgattt gacttggacc
    23521 aatcacaaca gaaggggctt gactagctgt tccagtataa gttaatgtgc catcgacaat
    23581 tgtagcatgt tcagagagat cctggacaac ctcatttgtc agaggttcat agacattatc
    23641 gataaaagtt tctagcggat aggtctcctg ggagctgttt tggatagcaa tgggtaccat
    23701 agacaagctg ataaggaaga tactggtaaa gagaagttga aaccagttga gctcgaaacg
    23761 tttggacagg ggcttacgaa acccccaaat acttgaaaaa taggaaaatg gatatggaag
    23821 cataggtatc tttctaaaag gtgttttcta tatgagtatt attatataga gaaatgcgct
    23881 ttatttcaag tctagggggt aaattgcttg ctacaaggat attatttaca gtgacaatcg
    23941 ctaatagtca atgaaaatca aagtgcaaac caggaagcta gctgcaggtt gctcaaagca
    24001 caactttgag gttggagata aagctgacgt ggcttgaaga gattttcgaa gagtataaaa
    24061 tgaaaaaggg tggcggggat aaattatccc ttgtcgccac cacttgtaag tcctgaaaca
    24121 aagttctttt gtaggaagaa gaagagaata cagattggaa gggcgatgag gatagcacct
    24181 gctgagaagt aggcaatctt caagtttttc gcattgttaa cgaaggtttg gagacctacg
    24241 gcaacagtaa agtattcttt ctcacgaagc aagaaactag agaggatgta gtccccgaaa
    24301 ggtcccatga aggcccagag agcttgtacg gcaaccattg ggcgaacaag tggtagaaca
    24361 atttgccaga agcggcggaa gtgtcctgca ccgtctagtt ttgcagattc gtctaaagac
    24421 attggcactg tatcgaagta gcctttcatg agccaagcat tcatcgggat accaccacca
    24481 acgtagagga agatgaggaa ccagttgtgg ttaagggcgt tcaacataag cgccataacg
    24541 aagaaggctg tcaaagcggc catagttggc accatttgga tgatcaagaa gaagaccaaa
    24601 ctttgtttac gagccaagaa gttgtaacgg ctgtaagcat aaccagcaag tacgatgata
    24661 cttgtttgaa cagccatggt aattaaggcg ataatcaaag tgttgaggta ccaagtaccg
    24721 tacaaggttt cagtgaagag gcctttaaag ttatcaaaat tgaggtcgat attagtatct
    24781 agtttaaagg ctgagacgtt acctgcttta aaggctgaca tgatggtaat caacagtgga
    24841 tagataatta caattgatag accaatcagg taaaggtaag taaggctttg agtcagtcta
    24901 cgtttgagtt taattgagtt attcatctta gacgtcctcc atatcaaatg cgtgtagttt
    24961 cttgaatgcg atcatagaga ttgagatgac aatgatagag ataatcaagg taacagctgc
    25021 cgccattgag tattgaggag atgtacctgt tgtcaaacgg tagatccatg agatcaagat
    25081 atcggttgaa ccagctccac ctccgacact accaggtcct ccaccattga agaggtacat
    25141 gatagagaag ttgttaaagt tgaaggtgta ttggctaatc aaagtaggtg ccgcaacagc
    25201 caaaatcatt gggaaagtga tgttgcggaa tttttgccaa gcgttggcac cgtcaatata
    25261 agctgcttcg taaaggtcgt taggaataga ttgcaagata cccaaagtca aaacgtagat
    25321 gtatgggaat ccgagccaac cttgcatcat aatcaaggca atcttagtcc aagttgggtc
    25381 tgttttccaa ggaataagag ctccatcaag gaaaggaagg aatttagcca agattggcaa
    25441 tacttgagtg ttgatagcac cgacactatc gttaaacatg tttgagaatg tcaagatagt
    25501 gatgaaggct gggacagccc aaggaagaag gaaaataaca ccaaagatac gttttccttt
    25561 gataaatggt tggttggcaa tgatagctgt gaagatacca attacgattt gtaaagtaga
    25621 agctgccaaa gcccaaatga tagtccaaga aagaacagaa ccaaaggcag aacggaaggt
    25681 actcaagctc caaatgtttg taaagttggt caaaccaacc cagtccaaca acttgtttgg
    25741 tggcaagtgt tggaagtcgt agttggtaaa ggcgatcatc aaggttacga taactgggaa
    25801 gataatcgcg aaggtcatgg caacataaga tggaatgatc aagaggtaag ggaagccatt
    25861 ttcataaatc cctttgatca tgtctttgag tgtgcgtgga actggaattc cattgttaat
    25921 gcgttttgca atcgtatgtg catctttgat atttgagaaa taaaagagta cataaacgat
    25981 tacaaagatt agatggaagg caccacgaat cagcataaag agggaattat cacgacctgg
    26041 tttgtcacca agagtgatga ggttgctcaa ttcaggggtt gcaagtgcta ggaagtaaag
    26101 gacaaatacg atggttacac caaggaagat aaaacctttg gctttttgtt tattgtaaat
    26161 ctgtcctaac ccaggaatga tagacagcag ggctgcttta ctaggttgtt gcttttccat
    26221 attaactcct ttcataggat actacttttt tataagaaag ctaaattatt tgtgtctcta
    26281 ttgataaatt caaaggggga tttgatttcc accccccttg aacaaatttt ttattcacca
    26341 aatttttgtt tgattgtttc tttgatcaat gttacagcat cgttagcagc tgttttagca
    26401 tctttttgac cacttacagc atcaaagagc atatttttcg ctggatccca aactgcagac
    26461 atttgagaga tgtttggcag tggttgagtg ttcttgaact gtttgataac agctgttgtc
    26521 aactcatcgt ttttaccttc agcgtatgaa cgagcctcag tattagctgg gatttcgtta
    26581 gtcttatcat ataatacttt ttgttgttca gttgcaacaa ggaagtctac aaatttttga
    26641 gaagcttcaa ggttcttaac ggcttgagga atgacccaag ctttaccacc accgaatgca
    26701 gcatattctt ttccatttgg aagagttggg atagttgcaa ctccgtagtt tactttagca
    26761 tctttaaagg cttgagcttt ccaaggtccg tcgatgatag cagctgtttt accttcttgg
    26821 aattgagttt ggattaagtt tccagcacct tctgtatctt gcataccttt aggccatttt
    26881 tcgtaccaag atttagcgta gttgatacct acgatagaac cgtcgtttgc aagaccgatg
    26941 tctttagcgt ctttaccgtt ttggccaaag acgtaagcac cgttaccggc aagaagtcca
    27001 tatgtatagt agaagtttgt ccagtcagct aggaaggcag tagttttacc atcttcacca
    27061 gcgaatgcgt atttgctatc tttagcaagg ttttccaagt cagcaaatgt ttttggagca
    27121 tctttcacca agtctttgtt gtagtacata acaagtgact cgataacggc aggagcaccg
    27181 taaactttac cattagcagc tgttacaaga gatttagttg tgtcgtctgt tttagcacca
    27241 tcgctcaatt tcacttctga aagttgtccg tcagaaccaa ggctacctac acggtcgtat
    27301 ggagccatca taacatcagg gacattacca gattggttgt caagagaaag tttatcaaga
    27361 cctcctagag catcaccagt tttaagagtg acttttactc cagcttcttt ttcataagct
    27421 ttagcaacct cttcaatata gctcttatat ccctcgtcta catatacagt gagttctttg
    27481 acttcagatg aaccagaatc agcaggctta tcagcagttt tgcttccgca agctaccaaa
    27541 agcaagctag caagtgtaac agttccaagc accgcagcgc tcttcataaa tttagatgac
    27601 atagtgtatt cctcccaaag aatagcaagt tttattgata aggaaacgca aacgttttcc
    27661 tttatgagct tagtatagca caaatagaaa acggttgcaa gtattttttg taaaaatttt
    27721 aaaaaatttt taagcttgat ttgatagcat aattttgcat tttaatagaa gaaaagtatg
    27781 aaatagataa gaatacagta tttttaataa aaatatatgg aatatgtcta aagagggaaa
    27841 ccaggagggg ctacctccct ggttctaatc cctatctatt ttctatggac gtttgtgctt
    27901 tgttacatat aaattcaagc tccctaagga ggttttgtac tttgtagact gtctcgtgag
    27961 agtcaaacct taggattaga tagttttaag ttatctttgc taaaatgagt tagtctcctt
    28021 aaaaataatc aaaaaagttt tttaaaaacg cttgcaatta tgcttgaaaa ggagtatact
    28081 tataagtaac gcaaacgttt gcgtctgcaa aatacgcaac gttccattat tttaacacac
    28141 gaggtgctat tatgaaaaaa cgtcaaagtg gtgtgttgat gcacatctct tctcttccag
    28201 gagcttacgg aatcggatca tttggtcaaa gtgcttacga cttcgttgat ttcttggtcc
    28261 gtacaaaaca acgttactgg caaatccttc cattaggagc aactagttac ggggattctc
    28321 cttaccaatc tttctcagcc ttcgcaggaa acactcattt tatcgattta gatatcttgg
    28381 tggagcaagg tttgttggaa gcaagtgacc ttgaaggagt tgactttggt agcgatgcgt
    28441 ctgaagttga ctatgctaaa atctactatg cacgtcgtcc tcttttagaa aaagcggtga
    28501 aacgtttctt tgaagtcgga gatgttaaag attttgagaa atttgctcaa gacaaccaat
    28561 catggcttga gctctttgct gagtatatgg ctatcaaaga gtattttgac aatcttgctt
    28621 ggactgaatg gccagatgca gatgctcgtg ctcgtaaagc ttcagcactt gaaagctatc
    28681 gtgagcaatt ggcagacaag ttggtttacc accgtgtgac tcaatacttc ttcttccaac
    28741 aatggttgaa attgaaagct tacgctaacg acaaccacat cgaaatcgtt ggggacatgc
    28801 caatctacgt agcggaagat tcaagtgata tgtgggcaaa tccacatctc ttcaaaacag
    28861 atgtcaatgg taaggctact tgtatcgcag gatgcccacc agatgagttt tctgtaactg
    28921 gtcagctttg gggtaaccca atctatgact gggaagcaat ggacaaagac ggctacaaat
    28981 ggtggattga acgcttgcgt gaaagcttca aaatctacga tatcgttcgt atcgaccact
    29041 tccgtggctt cgaatcttac tgggaaatcc ctgctggttc cgatacagca gcacctggtg
    29101 agtgggtgaa aggtccaggc tacaagcttt ttgcagccgt taaggaagaa cttggtgagc
    29161 taaacatcat cgcagaagac cttggcttca tgacagatga agtgatcgaa ttgcgtgaac
    29221 gtactggctt cccaggaatg aagattcttc aatttgcctt caacccagaa gacgaaagca
    29281 ttgatagccc acacttggca cctgctaact cagttatgta cacaggaaca cacgataaca
    29341 atacggttct tggttggtac cgtaacgaga ttgatgatgc gactcgtgag tacatggctc
    29401 gttacacgaa ccgtaaagaa tacgaaacag tggtacacgc tatgcttcgt acagtatttt
    29461 catcagttag ctttatggca attgcaacta tgcaagattt actagaattg gatgaggcag
    29521 ctcgtatgaa cttcccatct acccttggtg gaaactggtc ttggcgtatg actgaagatc
    29581 aattgacacc agctgtcgag gaaggtttgc ttgacttgac aacaatttat cgccgaatta
    29641 atgaaaattt ggtagattta aagaaataag acaataatca ggagacaact aaacatgtta
    29701 tcactacaag aatttgtaca aaatcgttac aataaaacca ttgcagaatg tagcaatgaa
    29761 gagctttacc ttgctcttct taactacagc aagcttgcaa gcagccaaaa accagtcaac
    29821 actggtaaga aaaaagttta ctacatctca gctgagttct tgattggtaa actcttgtca
    29881 aacaacttga ttaaccttgg tctttacgac gatgttaaaa aagaacttgc agctgcaggt
    29941 aaagacttga tcgaagttga agaagttgaa ttggaaccat ctcttggtaa tggtggtttg
    30001 ggacgtttgg ctgcctgctt tatcgactca attgctactc ttggtttgaa tggtgacggt
    30061 gttggtctta actaccactt tggtcttttc caacaagttc ttaaaaacaa ccaacaagaa
    30121 acaattccaa atgcatggtt gacagagcaa aactggttgg ttcgctcaag ccgtagctac
    30181 caagtaccat ttgcagactt tactttgaca tcaactcttt acgatattga tgttactggt
    30241 tatgaaacag cgactaaaaa ccgcttgcgt ttgtttgact tggattcagt tgattcttct
    30301 attattaaag atggtatcaa ctttgacaag acagatatcg ctcgcaactt aactctcttc
    30361 ctttacccag atgatagtga ccgtcaaggt gaattgctcc gtatcttcca acaatacttc
    30421 atggtttcaa acggtgcgca attgatcatc gacgaagcaa tcgaaaaagg aagcaacttg
    30481 catgaccttg ctgactacgc agttgtccaa atcaacgata ctcacccatc aatggtgatt
    30541 cctgaattga ttcgtctttt gactgcacgt ggtatcgagc ttgacgaagc aatctcaatt
    30601 gttcgtagca tgactgccta cactaaccac acaatccttg ctgaagcgct tgaaaaatgg
    30661 cctcttgaat tcttgcaaga agtggttcct cacttggtac caatcatcga agaattggac
    30721 cgtcgtgtga aggcagagta caaagatcca gctgttcaaa tcatcgatga gagcggacgt
    30781 gttcacatgg ctcacatgga tatccactac ggatacagtg ttaacggggt tgcagcactt
    30841 catactgaaa tcttgaaaaa ttctgagttg aaagccttct acgaccttta cccagaaaag
    30901 ttcaacaaca aaacaaacgg tatcactttc cgtcgttggc ttatgcatgc taacccaaga
    30961 ttgtctcact acttggatga gattcttgga gatggttggc accatgaagc agatgagctt
    31021 gaaaaacttt tgtcttatga agacaaagca gctgtcaaag aaaaattgga aagcatcaag
    31081 gctcacaaca aacgtaaatt ggctcgtcac ttgaaagaac accaaggtgt ggaaatcaat
    31141 ccaaattcta tctttgatat ccaaatcaaa cgtcttcacg agtacaaacg ccaacaaatg
    31201 aacgctttgt acgtaatcca caaatacctt gacatcaaag ctggtaacat ccctgctcgt
    31261 ccaatcacaa tcttctttgg tggtaaagca gctccagcct acacaatcgc tcaagacatt
    31321 atccatttaa tcctttgcat gtcagaagtt attgctaacg atccagcagt agctccacac
    31381 ttgcaagtag ttatggttga aaactacaac gttactgcag caagtttcct tatcccagca
    31441 tgtgatatct cagaacaaat ctcacttgct tctaaagaag cttcaggtac tggtaacatg
    31501 aaattcatgt tgaacggagc tttgactctt ggtactatgg acggagctaa cgtggaaatc
    31561 gctgagttgg ttggtgacga aaacatctac atctttggtg aagattcaga aactgttatc
    31621 gacctttacg caaaagcagc atataaatca agcgaattct acgctcgtga agctatcaaa
    31681 ccattggttg acttcattgt tagcgatgca gttcttgcag ctggaaacaa agagcgcttg
    31741 gaacgtcttt acaatgaatt gatcaacaaa gactggttca tgactcttct tgacttggaa
    31801 gactacatca aagtcaaaga gcaaatgctt gctgactacg aagaccgtga cgcatggttg
    31861 gataaagtca tcgttaacat ttctaaagca ggattcttct catctgaccg tacaatcgct
    31921 cagtataacg aagacatctg gcacttgaac taatactctt cgaaaatctc ttcaaaccac
    31981 gtcagcttta tctgcaacct caaagcggtg ctttgagcaa cctgcggcta gcttcctagt
    32041 ttgctctttg attttcattg agtataagat acaaatttat actaatacat tttgtaaaaa
    32101 agcgagtttc gattgaaatt cgctttttta aatgctgtgg atttgggtca atcttgtcta
    32161 aaaataggga aatcctagat acagtgaagg ctttaaatgc tggtttttac tgtctttagc
    32221 cttatatttt ttcgtagttg gttacctcat atctcttgta ttcgcttaca taaagtatta
    32281 taatataatt gtaggaaaga aggtgttttt atgatataca cacttaaatt ggtgttgttt
    32341 attacctttc ttgtaataag cttgttacct gataagattt ttggaaaaaa taaaaaaatt
    32401 tggaaaatag tttttgcaat attgacggca gtggcagcat tgtcatttat gtactaagtt
    32461 attttaagaa tgtagggaaa taaaccctac attcttttta gttttttctg ttttctaaat
    32521 tctatttatc caagcgcttc aacatttctt gcttcttcgc ttcaagttct gcacgctttt
    32581 cttcgatttc ggcatgtttt ttctcgagtt cagaacaact tgcatcattg ctaaattctt
    32641 ttcgccatca ggagataggg tgagtcgaca tgtctattac tcacccaaag cagtcctaca
    32701 aagcaggaat tttctgttac ttttttggaa atagtaacgt ttatacagct ttgacacttc
    32761 gtatcaaagc gccaaacaca ctccgaggga tttacagaaa gcagaaaagg aatgatctgg
    32821 tataagatca ttccttttct ctctttttct ttaagtaatt atatacaatg tacgacgaag
    32881 tcgtcattgc aatgctgatc caccacctaa agggaacttt aaacaagatt gataagataa
    32941 agaatataaa caacgaaaat acgttatacc caattaattt tattgtatat ctcatgatta
    33001 aaagttaatc cttctgttgt taggaatggc atcattttta tcccataatt gtgctaaata
    33061 agtccccggt gataataaat tcatagcgaa ttctaaagca acatcattta caaaccaact
    33121 acctagatat ctagaaattg ctgaacgaat agcacttttt gctgcatgtt ttccttttac
    33181 tttaattaga tttgcaaggc ctgcagtagt tcctcctaat gctaaagcta ttgcagtatc
    33241 taatagagca cccatttgat taactgtaat accttgccaa gctgctctaa atggagagta
    33301 tgtaggtggg attgtataat cgccttgtaa ttgtcggtta attacttctt tgatccattg
    33361 ttgtgagacg tctggatgaa aagattggat ttcgtttgca agtgtattga tttgttcttc
    33421 tgttagagaa gtgacaggtt gaagttccat atttgtttca atttgtgata cttgttcaga
    33481 agcgtataca gctgaaacac ttggaatcgc tgatacaatt aacacaattg acgtcaaaaa
    33541 aaccgaaata aatttcatta atttgttcat gaacttttct cctttttatt tgtatctgct
    33601 tacattttat catatactgt tattatagtc aaaaaaatat gctattatgt taaaaaaata
    33661 tttttcaaaa tataaatgga cggatttatt ttggatttta tttgttattt tgacctgcct
    33721 ctatattggt aaccatgatt tgtttactct caatcatcaa gaattctctt ttcgtggtag
    33781 cgtttggggt ctggtactgg ccttatatca cttactattc attgataagt ttgttatatc
    33841 gaatcgaaaa taaagattag agctatgctt gactggctac ttttaggatt gattttggag
    33901 gaagattttg tctctattat ttattatttt aaatttattt attttgtata agatctattc
    33961 tttgaggcgg gaaaaatcga aatacttgat ttatacggcc tatatcatat ttggggtaaa
    34021 tgtagtatat ggtattcaat ggttattaaa agaactgatt tcaactattt ccccttaatg
    34081 tgtatggaaa ctataacaaa acgcataaga ttaaggtttg tgtacctgtt cttatacgtt
    34141 tttgtcatat tgaagatttt cggtaagttt tctacttttg cgaagtctag tttatactca
    34201 atgaaaatca aagagtaaac tagccgtagg ttgctcaaag tacagctttg aggttgcaga
    34261 taaaactgac gaagtcagct caaaacatgg ttttgaggtt gtagatgaaa ctgacgaagt
    34321 cagctcaaaa catggttttg aggttgtaga tgaaactgac gaagtcagta accatacgta
    34381 cggcaaggcg acgttgacgt ggtttgaaga gtattagaat gctttcccaa ccaaaatctc
    34441 tgcttcgatg gtaatctctg tcagttggct ccagtcaatc ttgctctggt caacgtgaaa
    34501 gaggagagga gtcatactga gtagggcttg gagttgttct gctgtgatag tcttagtcag
    34561 agaggcagtt tgactagata ggatggtaaa gtgttcctgg aaatgctcct tgatatcttg
    34621 gttagaatac tccttgtttg tcagctggtc ctgtactctt tgacggattt ctttgaggtg
    34681 attttcagtt gggataacct ttatcaagat accgtctttg gataaaacgc gacgaaattc
    34741 tccatagttg gcaggtgaga agatatcaag caggatatcc atgctagcgt cttttatagg
    34801 aaggcgtgcc aagtcgccaa cgaaccaatt gactgcccag ttgggttcac ttttagcagc
    34861 gatttggact gaatctttgg agatgtcaaa ggcatagaaa gttttttcag agtgactttc
    34921 ttgtagtttg cgagaataga atccttcacc acaaccgata tccaaaattg ttgtggtagt
    34981 ttttgagctt gcaagcaagt cagatacagc atctaagata gcttggtaaa agccggcttc
    35041 taggatttgt tgacggtttt gaaaattttc cttgtcatag ttagcagatt gcttgatttg
    35101 aggtgctaga ttgacatagc caaatttcgc caagtcaaaa gaatgatggt tgcagcactt
    35161 gaaattagtc tctaacagag tcagattttc ttgacagata ggacaggcaa aggcagtcgc
    35221 agaagcaaaa cgctgaagtt tgggcttgag atttgtattc atagtttaag tgtatcaaaa
    35281 gaggcaaatg aaagcaactt taggaataag tagatgggag attcagtaga aataaaacta
    35341 attctccaat ttatagaatg aaattgcttt tatatctaaa ttgctatata ataatgataa
    35401 ggaggaaata agtatgttaa aagaagtatt aaccgttgca aaagttgcga aaaaatcttc
    35461 attatttttg ggtggtgtcg catttggtac ccttggtttg aaaatcttag caagtaagga
    35521 agctaaaaaa ggttattcta aagctttggc taaggcttac aagttgaaag acgagctaga
    35581 tgcatctgtt tctgtcgtga agcaacatgg agacgatgtc ttgcaagatg ccaaatattt
    35641 gtacgagcaa gagaaaaaag aagagcaatt agatagcctt ataggtgaat aatatgtctt
    35701 ttaaagtgct acatagagga taccaacata tccgactatc atcttctttt tcacttacct
    35761 tggatattca agactatctt cgttccttgg cgagagatga aaaggggatt gagtctatcc
    35821 agttttacat ggatcaacag cactttactc tacgcataaa agaaggcttt tctgtattag
    35881 ataatgcaga agccttttta aaaagaattg ataaagggaa agtttctgag ttgatgactc
    35941 ttcccattcg tagagaagag agtgcttatt ctattgtttc aggtgcagcg gttaagcgtg
    36001 tactttttcg tagttttgtg ccgtatccta ttcgctatat atggacttgt tatcaggctt
    36061 tgggttatat tagagaagcc tatcaaacac tagcgcgtaa ggaactaacg atggaagtct
    36121 tggactgttc ggctatttta ttgtctttgt ttatgaacca atccaagaca gctagcaata
    36181 tcatgtttat gcttgatttg gggaatcatt tagatcagtg gtccttgaaa aaaactgcaa
    36241 cagatttaga acagagtctt cttgcaaaag agagcgatgt attcctagta cagggcgata
    36301 cggttgttag tatcaagagt tccgatgttc aaataggaga tgtcttgatc ttatctcaag
    36361 gaaatgaaat tctgtttgat ggacaagtag tttcaggttt aggtatggtc aacgaaagtt
    36421 ccttgacagg agagagtttt ccagttgaaa aaagagagtc tgatttggtt tgtgcaaata
    36481 cagtattaga aactggagag ttacgcattc gtgtaacaga taatcagatg aacagccgta
    36541 ttttacagct gattgagttg atgaagaaat ctgaagaaaa caagaaaacg aaacaacgct
    36601 atttcatcaa gatggcggat aaagtcgtca aatataattt cttgggggct gggctgactt
    36661 acctattgac aggttctttt tctaaggcta tttctttcct attggtcgat ttctcctgcg
    36721 ctttgaaaat ctctactcct gtagcttatt tgacagttat caaggaaggg ttgaaccgtg
    36781 aaatggtgat taaggatgga gatgttctgg agaaatatct ggaagttgat actttcttgt
    36841 ttgataagac aggaacaatc acaactagtt atcctatagt tgaaaaggtg ttaccttttg
    36901 gagactatag tgaggaagat attctcagaa tcagtgcctg tcttgaggaa cacatttatc
    36961 atcctattgc taatgccatc gtcaagcaag ctgagataga gggaattgaa catgaggaaa
    37021 tgcatgggaa actccaatat atcgcaagca aggggatcaa atctcatata gatggccaac
    37081 cagttcttat tgggaattat gtcttgatgc aggatgagca gattcatatc agttcagaac
    37141 aaaatgcttt aattgaagag tacaagagtc actacaatct cttattcttg gcttatcaaa
    37201 atgaattgat tggaatgttc tgcattcata ctcctttgag aaaagaagca aaaacagcct
    37261 tggataaact taaggcacag gggaaaaaat tgattctggc aacaggagac accttgatta
    37321 ggacagagga attagtcaaa gatttgccct ttgatcaggt ctatacagac ttgaaacctg
    37381 atgggaaatt tgagttagta gagaaactgc agaaagcagg tcacactatt ttgatggttg
    37441 gagatggctt gaatgactca gcggctttaa ctctatcaga tatcggtgtg gtgatgaatg
    37501 agagtgcaga tatttctaag cagatgagtg atatcttatt gttagataat cgtttggatt
    37561 tcttccaaga gttggattcg ttatcatcat ctttgcaaac actcatcaag aaaaatattc
    37621 aggataccgt tgtcgtaaat agtagtttga ttggctttgg cttatttaat tggttcagtc
    37681 cttcaaatct ctctatctta cataatctaa caaccttgcg cattgtcctg cgtagcctgt
    37741 ctattaaaaa tagatagatg agagttatta acagcaaaaa ggagttacct ttctcgaggt
    37801 taactccttt gtttatagat agatgttgaa tagtttagta agtcaataca aagtattttt
    37861 tcttcccacg acggataaca gtcagttcat tttctaactt atcagcgtca ctcaagacat
    37921 agtcaaggtc ttggatgcgg tcgccgttta cgtagatggc tccgttttgg acgtcttcac
    37981 gggcttggcg ttttgagtta actataccag atgagacgag cagttccacg atattgttgt
    38041 tttcgtctgc ctgtacttgg tagtttggca caccacgaag tccttgtttg agctctttga
    38101 cagaaaggtt tttgatgttt cctgcaaaga gttgctcagt gatgttaagt gcttctttgt
    38161 aggcttcttc tccgtgaaca agtgtaacaa cttcacgagc caagactttt tgagccaagc
    38221 gttcgtgtgg cgctgcttca aattgtttac gaatatcttc aatctcatca agtgacaaga
    38281 aagtaaagat tttcaagaag cgaacagtgt cagcgtccat cacgttcatc cagaattggt
    38341 acatttcgta tggagaagtc ttttcgggat taagccagac ggcatttcct tctgatttac
    38401 caaatttctt accagttgca tctgtgatta gtggaacagt gataacgtga ccagtcttgt
    38461 ccgccttacg acgaagcaat tcggtaccag ctgtcatatt tccccactgg tcagaaccac
    38521 cgatttgaag agtgacatta tggtcttggt taaggacgaa gaagtcgtac ccttgcatga
    38581 tttggtaagc gaactcagtg taagaaattc ctgtttcgat ccgtttttta acagattcct
    38641 tactcatcat gtagttgacc gtgaagtatt ttccaatatc acggaggaag tcaatgaagc
    38701 tgatgctgcc aaaccagtcg tagttgttga ccatgacagc cttgttttcg ccattttcaa
    38761 agtcaagaaa acgagaaagt tgtccttgga tagacttgac ccagccatct actgtgtctt
    38821 ttgtttggag actacgttca gcatctttga aggacggatc tccgatgaga cctgtagcac
    38881 cgccaacgag cgcataaggt ttgtgacctg ctagttgcaa gcgacgactt gtcaagattg
    38941 cgacaaggtg gcctaggtga aggctgtcag cagttggatc gtagccagta taataagaaa
    39001 cttgaccttc ttctagggct ttacgcaaag cttcttcatc agtcgtttga aatatcaaac
    39061 cacgatcttt tagctcatca aaaatgtgca tgtgtctttt ctccttttta aaattattgt
    39121 ttctacctat tgtatcacaa acttgggcaa tagcctagca gaatagggaa gaaagtggct
    39181 attttattga aaatttccct tttgtggtat aatagataga gtgaggaaat ccatgcaaaa
    39241 tcaattaaat gaattaaaac gaaaaatgct ggaatttttc cagcaaaaac aaaaaaataa
    39301 aaaatcagct agacctggca agaaaggttc aagtaccaaa aaatctaaaa cattagataa
    39361 gtcagccatt ttcccagcta ttttactgag tataaaagcc ttatttaact tactctttgt
    39421 actcggtttt ctaggaggaa tgttgggagc tgggattgct ttgggatacg gagtggcctt
    39481 atttgacaag gttcgggtgc ctcagacaga agaattggtg aatcaggtca aggacatctc
    39541 ttctatttca gagattacct attcggacgg gacggtgatt gcttccatag agagtgattt
    39601 gttgcgcact tctatctcat ctgagcaaat ttcggaaaat ctgaagaagg ctatcattgc
    39661 gacagaagat gaacacttta aagaacataa gggtgtagta cccaaggcgg tgattcgtgc
    39721 gaccttgggg aaatttgtag gtttgggttc ctctagtggg ggttcaacct tgacccagca
    39781 actaattaaa cagcaggtgg ttggggatgc gccgaccttg gctcgtaagg cggcagagat
    39841 tgtggatgct cttgccttgg aacgcgccat gaataaagat gagattttaa cgacctatct
    39901 caatgtggct ccctttggcc gaaataataa gggacagaat attgcagggg ctcggcaagc
    39961 agctgaggga attttcggtg tagatgccag tcagttgact gttcctcaag cagcattttt
    40021 agcaggactt ccacagagtc ccattactta ctctccttat gaaaatactg gggagttgaa
    40081 gagtgatgaa gacctagaaa ttggcttaag acgggctaag gcagttcttt acagtatgta
    40141 tcgtacaggt gcattaagca aagacgagta ttctcagtac aaggattatg accttaaaca
    40201 ggacttttta ccatcgggca cggttacagg aatttcacga gactatttat actttacaac
    40261 tttggcagaa gctcaagaac gtatgtatga ctatctagct cagagagaca atgtctccgc
    40321 taaggagttg aaaaatgagg caactcagaa gttttatcga gatttggcag ccaaggaaat
    40381 tgaaaatggt ggttataaga ttactactac catagatcag aaaattcatt ctgccatgca
    40441 aagtgcggtt gctgattatg gctatctttt agacgatgga acaggtcgtg tagaagtagg
    40501 gaatgtcttg atggacaacc aaacaggtgc tattctaggc tttgtaggtg gtcgtaatta
    40561 tcaagaaaat caaaataatc atgcctttga taccaaacgt tcgccagctt ctactaccaa
    40621 gcccttgctg gcctacggta ttgctattga ccagggcttg atgggaagtg aaacgattct
    40681 atctaactat ccaacaaact ttgctaatgg caatccgatt atgtatgcta atagcaaggg
    40741 aacaggaatg atgaccttgg gagaagctct gaactattca tggaatatcc ctgcttactg
    40801 gacctatcgt atgctccgtg aaaagggtgt tgatgtcaag ggttatatgg aaaagatggg
    40861 ttacgagatt cctgagtacg gtattgagag cttgccaatg ggtggtggta ttgaagtcac
    40921 agttgcccag cataccaatg gctatcagac cttagctaat aatggagttt atcatcagaa
    40981 gcatgtgatt tcaaagattg aagcagcaga tggtagagtg gtgtatgagt atcaggataa
    41041 accggttcaa gtctattcaa aagctactgc gacgattatg cagggattgc tacgagaagt
    41101 tctatcctct cgtgtgacaa caaccttcaa gtctaacctg acttctttaa atcctactct
    41161 ggctaatgca gattggattg ggaagactgg tacaaccaac caagacgaaa atatgtggct
    41221 catgctttcg acacctagat taaccctagg tggctggatt gggcatgatg ataatcattc
    41281 attgtcacgt agagcaggtt attctaataa ctctaattac atggctcatc tagtaaatgc
    41341 gattcagcaa gcttccccaa gcatttgggg gaacgagcgc tttgctttag atcctagtgt
    41401 agtgaaatcg gaagtcttga aatcaacagg tcaaaaacca gggaaggttt ctgttgaagg
    41461 aaaagaagta gaggtcacag gttcgactgt taccagctat tgggctaata agtcaggagc
    41521 gccagcgaca agttatcgct ttgctattgg tggaagtgat gcggattatc agaatgcttg
    41581 gtctagtatt gtggggagtc taccaactcc atccagctcc agcagttcaa gtagtagttc
    41641 tagcgatagc agtaactcaa gtactacacg accttcttca agggcgagac gataattctc
    41701 taaatgaagt ggccaatcaa tggattgcca cttttttcct ttcgtgttac aataagggta
    41761 tgaatcagta tcagaaaaag attgttaacg gaaaaattta ttcgctccta tccggcttaa
    41821 tatggggaat ctgtggaatt ttaggagagt acttctttac tcattatcag gtgtcttcgg
    41881 gctggattac ctctatgcgt ttgacactgg cagggagtct tgtactcatt tggtctgcaa
    41941 tacaattaaa atcgcaagtg ctagatattt ggcgagacaa gaaaaattac ctgccctttt
    42001 tagcctatgc tattttgggg attttttcag ttcagtattt tttctatctc tgtgtagaat
    42061 actcaaatgc tacgacagca actattttac agtttattag ccctgtcttt atcctctttt
    42121 ataatcgctt ggtttatcaa aaacgagcgt caaaaagcgc tgttttctat gttttggttg
    42181 ccatgctggg tgtttgcttg atggcgacaa agggagatct ctctcagtta tccatgacgc
    42241 cgctagctct tataacaggt ttgctgagtg ccatgggtgt tatgtttaat gttatcttgc
    42301 cccaaccttt tgctaagcgt tatggttttg ttcctacggt tgggtggggg atgattttgg
    42361 caggtttgtt tagcaatgtc ctctcgccgg tttatcagct ttcctttact cttgatattt
    42421 ggagtatctt gatttgcctc attatcgctt tctttggaac ggcttttgct tttttcattt
    42481 ccatgaaggc tgtgtccttg gtttctcctt tggtggttgc cgttatcagt gccagtgaac
    42541 ctctctcttc tgctctcttg agtgttttgt tcttaggatt agtagtggat tggtccctcc
    42601 ttctagctat agccttgatt attttaccca tgatattttt gtctatagaa gaagcgaaag
    42661 aaagtagata aaaagtcttt tcttaattct aaaagtgtgc tatactagaa tagtcaataa
    42721 aacacgggga gatagttgtg aagagtgttt ttaggttgta tcggtagggg cttgctttta
    42781 ccgacagcac gttttatctc acatccctaa aaaatcatac ctaaaaacag acaaaaaggt
    42841 ttcaaatttg aggccttttt tggtagaata ggtatcatta taacgaacca ggaggcacct
    42901 atgactgcta caaaaatgaa cgctcaagaa attatccaat ttatcgccaa tgctgaaaag
    42961 aaaaccagtg tcaaagtaac ctttgagggg caactcgcaa ctgctgtgcc tagctctgtt
    43021 gtcaaactag gaaatgtcct attcggagac tggaaggacg tggctccgct tcttgaaggt
    43081 ttggtagaaa atcaagatta tgttgtcgag caagatgctc gtaattctgc agttcctttg
    43141 ctagataagc gtgctatcaa cgctcgtatc gagccaggtg ctattatccg tgaccaggtg
    43201 gaaattggtg acaatgctgt tatcatgatg ggagctgtta tcaatatcgg tgctgaaatc
    43261 ggtgctggaa ccatgattga catgggtgcc atccttggtg gccgtgctat cgttggaaaa
    43321 aatagccacg ttggtgcagg tgcagttttg gcaggtgtga ttgagccagc tagtgctgaa
    43381 ccagtccgtg tcggagacaa tgttcttatc ggtgctaatg cagtggttat cgaaggagtc
    43441 caaatcggta gtggttcagt tgtcgctgca ggagctatcg ttacccaaga tgtcccagaa
    43501 aacgtggtag tagcaggtgt tccagctcgt atcatcaaag aaattgatgc ccaaacccaa
    43561 caaaaaacag cgctagagga tgcgcttcgt accttgtaat tgtaaaagta aaaaagaggc
    43621 ggaacccttt ttccagcctc tttctgctat atcggaggac agatagatgt tagatttgat
    43681 tcagactaga cgagctttac accagattcc agagattggc ttggaggagt tcaagactca
    43741 ggcttatttg ctggatgtga ttgagaaatt gactacgggc aaggattttg ttcaaattcg
    43801 tacttggcgg acagggattt tggtctacct gcagggaagt cagccggagc gaaccattgg
    43861 ttggcggaca gatattgatg gcctgcctat cgtcgaacaa acaggtctac cttttgcttc
    43921 tcaacaccaa ggtcgcatgc atgcctgtgg ccatgatttt catatgacca ttgccttagg
    43981 ctgtcttgag cgcgcccttg aggagcaacc caagaataat ctgctctttc tatttcagcc
    44041 tgctgaagaa aatgaagctg gtggtatgct catgtatgag gatggtgctt ttggagattg
    44101 gttgccaaac caattctatg gtctccatgt tcgtccagat ttgaaagtcg gccagattgc
    44161 gactaatact catacactct ttgcaggaac ttgcgaggtg aagatccgtt tcaaaggcaa
    44221 aggtggccac gcagcttttc ctcatgaagc caatgacgcc ttggtggcgg ctagttactt
    44281 tgtgacccaa gtgcagtcag ttgttagccg caatgtcaac ccaatcgagg gagcagtggt
    44341 gaccttcggc gtttttcaag ctggaaccac caacaatgtc atcacagaca cagctttttt
    44401 acatggaact attcgtgcct tgacacagga catgagtctc ttggtgcaaa agagggtaaa
    44461 aacagttgca gaaggggttg cagctgcctt tgatatggaa gtcgaagtgg aactcaaaca
    44521 aggtggatac ctacctgttg agaacaatcc agccttggcg cgtgaactga tggacttctt
    44581 tgacgaaaaa gacggaatcg agttgattga tatcgaacct gctatgacag gcgaggactt
    44641 tggttatctc ctttcaaagg ttgatggcgt gatgttttgg ctaggtatcg atagtcccta
    44701 cgctcttcat caccctcaaa tgagtcctaa ggaagaagtc ttagctattg gggtggctgc
    44761 ggtgtctagt ttcctgaaaa agaaggcagc agaatagagg gcttgtctat gaaatcggaa
    44821 ttacgcaagc aagtcttgca aggaatgaag gctatatctc aagaacaaaa acagtttata
    44881 gatcaaactt taaccgagcg gcttttacac catcccttct atcaagaagc caaggtcatc
    44941 gcaacctacc tctctttttc tcatgagttt caaacgcggg aactgattga gcaggcgctg
    45001 aaggacggca agaaggtttt aatacccaaa acttatccca aggggcgcat ggactttgta
    45061 gtctatgatc tgcagcagtt ggtaaaaact gcctttgcct tactggagcc acagggagat
    45121 ttggaagtgg tggatgtatc tcagattgat ttgattcatg ttcctggcct ggcttttacg
    45181 acggatggat atcggattgg atatggtgga ggttattatg accgctatct ggaacatttt
    45241 tctggtcata ctttgagtac ggttcatcct tgtcaaattc aggactttat acctgaaaac
    45301 catgatattc ctgttcagga ggtattaatt gatgaaggaa atctttgata gacgttaccc
    45361 tgtgacgagt ttcttcctct tagtgacggc cttggtattt ttactaatgt tggtcactgc
    45421 aggcgggaac tttgacaggg cagatacatt atttcgattt ggagccatgt atgggccagc
    45481 tattcgcctc tttcccgagc aggtttggcg tctcttgtct gccatttttg ttcatattgg
    45541 gtgggaacat ttcattgtta atatgctttc actttattat cttggaaggc aggtagagga
    45601 gattttcggt tctaagcagt ttttctttct ctatctttta tcaggaatga tgggcaatct
    45661 ctttgttttt gtatttagtc ctaaatcctt agcagcaggc gcctctacct ctctttatgg
    45721 gctatttgcc gcgattattg ttcttcgcta tgcaactcgc aatccttata ttcaacagct
    45781 agggcaatcc tatctgacac tttttgtggt taacattatt ggaagtgttc tgattccagg
    45841 aatcagccta gcaggccata tcggtggtgc agttggtggc gcatttctag cagttatctt
    45901 tccagttaga ggagaaaaac ggatgtataa taccagccag agattaggag cggtagtctt
    45961 gttcgtagga ctcgccattt tgcttttcta caagggaatg ggaatgtgac gaagttgaaa
    46021 gaaaatttgt gtaatgaaaa aagataaggc attttttgaa ccttatcttt ttattttatt
    46081 ccttctcagt caattctttt ccaagttgga tgaggtaatt cttcaaatca tctttgactt
    46141 gtggatgttt gagggcgtag tcaatagatg ttttcataaa gccaaactta tccccaacgt
    46201 cgtaacgagc tcctgtaaat tcacgggcaa aaacacgctg tgttttatta agagtatcga
    46261 ttgcatcagt aagttggatt tcatttccag caccaggagc ttgcttttcg agaatctcaa
    46321 aaatttcagg cgtgaggagg tagcgtccga taatagcaag gtcgctagga gcgtcctctg
    46381 gagctggttt ttcaacaaag gtttcaacac tgtaaagacc atcttttcct tcgccttgcg
    46441 gagcaataac cccgtaagca gatacttcgt catgagggac tggcatgaca gcgatagtag
    46501 acgcgtgggt acgctcgtag tcatccatga gttgtttggt aagtggaaca gtcttttcgt
    46561 ctgtgatatc catcaagtca tcacccagca taacaacaaa aggttcattt ccaacgaaag
    46621 ccttggcttg caaaacagca tcgccgagac cacgtggatg cgtttggcgg ataaaatgca
    46681 ggcgcatgcc agttgtttca tcaactagct tcagaagatc tgttttccct ttttctttga
    46741 gattatattc caattcaaag tttgaatcaa agtggtcctc aatagaacgt tttgatttac
    46801 cagtgacaac tagaatatct tcaatacctg atttgagagc ttcttccacg ataaactgga
    46861 tagttggttt gtctacgatt ggcaacattt ctttggcaag ggccttggtt gctggtaaaa
    46921 atcgagttcc tagtccagca gcagggatga ctgcctttct aacttttgat gtcataaaaa
    46981 tcctttctat agagggttaa gaccactcat tttctgcttt aaattcattg ttcatgatgt
    47041 cataaatggc atctttgata ttggttccgt gataaataac ttggtaaata gcctgtgtaa
    47101 tgggcatata gactccaagt tcttgggcta gttcataggc tgctcgagtc gttgaaattc
    47161 cttcgattac catgcccata ttagcttcta tatcagctag ggattctcct cgtccgagag
    47221 catctccagc tctccagtta cgagagtgga tggaagttcc cgttacgatc aaatctccca
    47281 caccagataa gccgctatag gtcaatggac tggccccgag tgctacccct aggcgggtga
    47341 tttctgctaa acctcgagcg atgatggctg ccttagcatt atcaccaaat ccaagaccat
    47401 gtaaagctcc agcaccgaca gcaataatat ttttaagagc accagcagtt tcaaccccga
    47461 taacatccgt attggtataa agtcggaagt agtgattact aaatagctcc tgaacgtatt
    47521 gagctgtttg taaatcttta gaagcagcag ttattaaagt taggtcacgc acaatggtct
    47581 cttctgcatg actaggccct gaaacaacga cgatatcact acggagatgt tcaggaattt
    47641 cttcttcaag aatggttgat aatcgtttat ggctatcagg ttctaatccc tttgatgcgt
    47701 gcatgatgat aaccttatgg tccaaggttt gtgcaacttg ctgggcaaca agtcgtgtca
    47761 cttttgttgg gacaacaaac aaaatcgcat ccacattttt caatgtttct gctaagtcgg
    47821 tgtaggcaat gatattttcg tctagaacga catctttaaa gtagtgctta ttagtatggt
    47881 gtgtattaat ttcattgatt tgctcgggaa gatttcccca aatacgtacc tcgtgtccat
    47941 tgtcatttaa gacttgtgaa agggcggttc cccaagaacc aggccccaag acggcgacgg
    48001 tttgtttttc catgatttcc tccttgatag atttctttct cttattctat catattctag
    48061 gggattttgc acttgcatta ctggggtatg gtggaaaaat acacaaagac cgagatgaag
    48121 ggataaactc ttagtcttta gttaaagtga gaagaaatct gatagatagt ttgattcagt
    48181 atatgcttat aatagaggta aacaactcag gaggttcttg taggttgcga gagtttggcg
    48241 aaaaaattaa aagattacgt ttggctaaaa aaatcagtcg ttcagaattt tgtggtgatg
    48301 agtctgaatt aagtatccgt caattaatta gaattgaaaa tggagaatcc agaccaatac
    48361 taacaaagtt aaaatatatt gctgaacgtt tggaggttga agattacaag ttgatgccaa
    48421 gttatataga gttggataag gaatacctag aattgaagta tttcttgatg aggactccta
    48481 catacgaaga tgaaactatc gcccaaaaga aagagagtgt ttttgctaag atttttgaag
    48541 agtattatga taggctacct gaggaagaaa gatttatcat cccaaattat tcatatctag
    48601 cactagcgaa ctacacagtt caaaaattac cagaaaagct agttgaaata ctgtccttct
    48661 ggtgattttg cttaatttct gatgttagag acataattga ggagatttgt cttgattttt
    48721 tcctaaaaaa gggcagactc ctcccttggt ttgatgctcg atttttaaaa taaggtgact
    48781 tattctgtta ggcatgtttt cccctgccct ctagctctat atggaacagg gagtatcaga
    48841 tttatctggc agattgtatc aaataaggct tgaaactgtt ttgaataggc gtatagactt
    48901 gagaatttga gaatatgtcg tctagcagta gagacatatt ttccggcaat atgaaggaag
    48961 agacgtcgaa aacgcttgat agtcaaggcc tttacttcat caccagctag ctgctttaaa
    49021 aagaggtaga gattataagc cagacagccc atcatcatac gtacttcatt cttaatcatg
    49081 gtcgaactat ctgtcttatc cccaaagaat cctgctttcc tttctttgat aaagttttca
    49141 gcattccctc gttcacgata gaattgaaac agctcctcac tatctacact gcttaaattg
    49201 gtcaaatgaa cttttttaca accataaaaa agagcactta atcgtactct tctcttttaa
    49261 ggattagttg aattaattca aatccactag ttctcctgtt tctaggtaga ctaggcgttc
    49321 acaaatgtta gcaatgtaat cagcgaagcg ttccagatgc cctatgatat aaaggtattg
    49381 tgttccattg ggaattgagg tttcttggtc tttcataagt ccaatgattt cctttgataa
    49441 ggcataataa tattggtcaa tctgttcatc tttttgagca atactaatag cttttgaggc
    49501 ttggtgcaaa ggaaaggcaa ccaataaatc ggatagcatg ctgagggata atttacccat
    49561 ttggtgtaac tgttcttcgt caggggctag ttgattttct tttagttgca aaacagcttt
    49621 agcaatgcct gccatatggt ctcccatacg ttcaaggtct gaacaagaag acatgatgct
    49681 aatcacaaat cgaaggtcag acacttgtgg ctgctgcaag gccaacaaac gggcacaggt
    49741 caattcgata gcgctttgac cttggttgat agcatgatcc ttattgataa ttagctctgc
    49801 catctccttg tctttggagg ctaaggccag taaggttttt gaagctgttt caaggacaag
    49861 ttgccctagt cctaaaaagg attgttctaa ttcatgcaat tctaagtcaa attgatttct
    49921 cataggtttt tccttcctta tccgaaccgt cctgaaatat agtcttctgt gcgctgatct
    49981 tttggattgg taaacacgtc aacggtgtct ccaaattcgc aaatttctcc tgttaagaaa
    50041 aaagcagttt tatctgaaat acgtgaagct tgttgcatgt tatgggtaac aatgataatc
    50101 gtataatcct tttttagttg ctgaatgagg tcttcaattt ttaaagtgga gatagggtct
    50161 aaggctgaag tcggctcatc cattaacaga acatcaggtt ctactgctaa agctcgcgca
    50221 atgcaaaggc gttgctgctg accgcctgat aaggacatgg cactcttttt aagattatct
    50281 ttgacttcgt cccaaatggc tgcccctttt aaagattttt ccactaaggc atctaattgt
    50341 tttttgtctc gaataccatg tgtccttggg ccataagcca cgttatcata gatagacatg
    50401 gcaaagggat taggctgttg aaaaaccatc cctacacgct tgcgtagctg attaaggttg
    50461 aatttgctac tataaatatc ttgctcatct aagaggactt ggccttcaat atggcaagaa
    50521 ggaaccaaat cgttcatccg attaagggtt tttagaaaag ttgatttacc acaaccagat
    50581 gggcctatca aggcagtaat ctgtctttct ggtaattgaa tcgaaatatt ttttaaggct
    50641 tgaaaatccc cgtaaaataa gtctaggtgt ctgactgaaa atgttcccat actaggaagc
    50701 tcctttcaca agttttcgag ataataagct tgatagagta tttatcatta aaacagtaat
    50761 aatcaaaatc acaccggtag cataggcttc attgacatgt agcccctcac ttgacagcat
    50821 atacatatgc agggctagag aacgacctga agacatgaga ctacttggcg tattggtaga
    50881 ggtacctaat gtatacatga gggcagctgt ctcaccaacg atacggccaa tagctagtat
    50941 cactccagct aaaatacctg gcatggcaac tggtagaaca attctaaaaa cagtccgtaa
    51001 cttacctgcc ccaagtccat aacttgcttg acgcatgcta tcactaacag ataaaagggc
    51061 ttcttctgtt gagcgaataa tgactggcaa caccatgatg actgaggtta agattcctga
    51121 taacagagag tattgaaaac ctaagaagac tacaaagaag agcatgccaa acagaccaaa
    51181 aacaatggaa ggaatcccag acaaggtatc tgaggccaat cgcataattt taacacaaag
    51241 ggaatctttt tttgtatatt ccacaagata aaaaccagca aaaatcccta tgggcaaggc
    51301 taaaagaaga gcaccaaaaa ccagaataac ggtggaaata atcgctggca taagggaaat
    51361 gttctcagaa gtataagtcc aagaaaagag ggatagactt agatgaggta agcctttgat
    51421 gaggataaaa ccaatgatta aaaagagaga gccaaaggtt aaagctgaaa aacaataaac
    51481 gagaagtttt agcaggtatt tactcataag atgattttcc tttcaagtag gcaaagtagg
    51541 cattaatcaa gagaataagg aaaaagagaa ctgctgaggt tgcaataagg gcttccctat
    51601 gctgacctga tgcgtaagcc atttccagaa caatattggt tgttaaggtt ctggttcctg
    51661 aaaagagtcc acttggaata atcggctggt tgcctgccac caaaataact gccatggttt
    51721 cacctactgc gcgaccgatt cctaaaataa ctgctgataa aataccagat ctcgcagctg
    51781 gcaagatgac actaaaaata ctccgttcat gactagctcc tagagccaag ctaccagaat
    51841 aatacgtttt gggaactgtt cggatagcag attctgacaa actgataatg gttggcaaaa
    51901 tcattattcc taatagtaac gaagcggtta ggacactcat gccatttcct aaaaaggttc
    51961 taatccaagg caccaataat tgtaggccga aaaaaccata aacaatagat ggaatggccg
    52021 ccatcaagtt gatagctgat tttaagaagc catagacggg ctttggacaa taataaacca
    52081 taaacaccga tgtcaagatg cctgttggca ccccaatcac aatcgctcct aaggtaatta
    52141 ataaggaacc aacgatcatt ggtaaaatac catagcttgc cggaatgttc gttggcgacc
    52201 aatcactgcc taataaaaaa cgggcaaagc cgtagttagc catgaaaggt aagccattac
    52261 taaaaataaa gaaacagatt agcaaaatag ctacaacagc tactgttgca ctcatgaaaa
    52321 aaattgccct aaaaactgct tctttgaagg cttgttttat cacatcttgt cctttctagt
    52381 gaagaaagta agggagatac gacacctccc tacttgcctt ctttatctta ttgtacgatg
    52441 aaacgtctgc atctctttag agatttatgg agcaaacatt ttatttaatc ttgtcccagg
    52501 tggttaattt gccactaaaa acgtctgcaa gttcagccat actgacttgg cttgccttat
    52561 tgtcattatt gaccacaaca gcaataccgt ctaaagcaat agcatcatgg gtgagactct
    52621 taccttcttc aggagttaat tccctagaaa ccataccaat atcagcggtt ttctccttaa
    52681 cagcggtaat acctgctgaa gatccattag aggtaatatc aatcgtaact tctggatttt
    52741 cttttttata agcttctgct aatttttcca ttaaagaaga tactgaagtg gaacctacaa
    52801 cagacaactt gcctgataag tgttggcttg tatattctgt ggtttcggtt ttagcttcaa
    52861 taaatttatt atctgtgacc acttgttgac cttgtttgga gtggataaag ctgataaaat
    52921 cttgacctag cttggaaaga ttagaagacc aaacaatgtt gaagggacgt tgaagagggt
    52981 attcaccatc taaaactgtg tctcgactag ccttgacacc atcaatctct aaagccttga
    53041 cagatttcgt taaagatccc aaggagatgt agccgatagc attagcattc ccttgaactg
    53101 ctgagagaac accttctgta ctattttgaa tcacagctgt tttggtagtg ttgtcaattt
    53161 ttttatcacc gtcttttttg agaatccctg tgatttctgt gaaggcaccc cgtgttccag
    53221 agccattttc tcgtgaaatc acctcaatcg ttcctgaagc tgactgtttg gaagcagctg
    53281 actgattgcc acaggcaaca agcccaaatc ctgataagcc aatggctgca agagtaagca
    53341 tttttttgaa tttcataata atcaccttta tctctatgta tttttcttgt gtaggcttac
    53401 tacatttata gtctaacaag tctttgtaaa ggtttatccc tgattcatgt aaagattgtg
    53461 taaagaatca aaaaaagcca cttttgaaaa atggctgctc ctaaaaatag ctttaaaaat
    53521 tattagtcct gtgcgaaaga ttggttagga agaaaaatcg tgaagcaact gcctctgcca
    53581 agctgactcg tcaccgtgac ttggccacct aataattgac tgagttcttt gacaatggca
    53641 aggccaagac cagtgccacc agtttgtctg cttcgacctt tattaactcg gtaaaaacgt
    53701 tcaaaaatac gatcctgctc taattgacta ataccaatcc ctgtatctga tacagaaatc
    53761 ttaatgcctt cgttcacctt ttgggtcttg acctcaattt ttcccccttg ttcagtgtaa
    53821 cggatggcat tggataaaag attgagtaag atttgggaaa gtaattgact atctgatacg
    53881 agggtgacat catctggcac ctgcaccttt agctgtaaat ccttcttctt gagctgaggt
    53941 tgcaagcttt gagtcaaatc ctgtacaaat tctgccaaag aaagggtcgt ccattgtata
    54001 ggcatttgtt gagccttaga taaggtaaga agatgctcaa caatatgctc aagacgcaaa
    54061 ctttctttgt aaataatgtc tagaaagtca tccttgagcg cttcttcttc agctgacatc
    54121 cccttaatgg tttcagcaaa gcccttaatc gaagtaactg gtgtcctcaa ttcatgggag
    54181 gcatttgaga caaaggctaa atttaacttt tcataagttc taatcgttgt taaatcatat
    54241 agcaagacga gcacagcttc cacagattgg gtggggctaa aaacgggaac tgctgtcact
    54301 tctaaaatca agtcaccctc atgaaaccca cttacttctt gttttaacct tgttttttga
    54361 tcaaaggctt ggtgaactaa attccgaata tccatccgtt tgaggtcatc aagtgaactt
    54421 atgtcgccgt ccacatcggg aaaataatga ggcagagagc gactggataa taacatctga
    54481 ccttgagcgg aaactaaaaa cgtccccatg gttaggtgcg acagaagaac ctccattgtt
    54541 tcggctagat ccttgtattg ctgatcctgt tgggagactt tggtttttag gccagacaca
    54601 tactgagcca aagactttaa gtcttcttgc cctttttcta aaaagtattc actactggtc
    54661 aagagaggtt ggtgcaaggt ctcaaaagca acttcccatt tccaaaggca aaagagccag
    54721 tagccaccta gtcccaaaga aagggctaga agaaagagac cgatgccttt actgatccaa
    54781 gttaatgcca tccctgcaat cagaatgagg ctaacactta gattgactag ccaaaattga
    54841 aggtagcgtt tcatctataa ctccttgaac ttataaccat acccccgaat ggttcgaata
    54901 aattgagggg ctttaggatt gtcttcaatt ttttccctta acttaccaat atgaacgtcc
    54961 accaaacgtg tttcctgccc aaagtcatac ccccagatac gttccaaaag acgctctcta
    55021 gtcagtgtca tgttgggatg tttcataaga tagagcaaga gttcaaattc ttttggggtc
    55081 aaactcagta acttattcgc cttgtagact tcatgacgct cagggtatac tttcaaggtc
    55141 ccaaatagcc aagaatcgtc agcgatatta tctgaatcat ctccttcttg ttctccttta
    55201 gttcgcctga ggacagcctt gacacgcgcc agcaattctc tagggctaaa aggcttggtc
    55261 aggtagtcat cagcccctaa ttccaaggcc aaaaccttat caaattcatc acttttcgca
    55321 gaaaccatca taattggagt tttgacgcct ttggctctca gccgcttaca aacttccatg
    55381 ccatctaatt gtggtaacat gatatcaagc aagataaaat caaagggttc tgtttctgcc
    55441 aaagctaagg ccttccgtcc atttgttacc aattgagtag aaaagccttc cttacttaaa
    55501 tggtagtcaa gcaatttcag aatgtgttct tcatcatcca ctaataagac ttgttttgtc
    55561 atctattatc tcctattggt aacattataa cacaattatc agaaatccta acattgctaa
    55621 atcagattaa atttgcttat caagactagt atctggtcaa acgctcaatc atctccttgt
    55681 gctctggata ggtcgccagt agatctaccc tttcaaataa ttcaaaatcc tcaaattcaa
    55741 aaccaggagc aacaagacaa gaaaccagag catcatcctt atcaactgtt gatccccaaa
    55801 tagtgccctt aggaacacag tagtgaagtt gttgcccttt ggatatgtcc aggcctaaag
    55861 tgactgcttc gtagtgacca tctgctgtaa tcatgtgaac agtaagtggg gattctgcat
    55921 gaaaatacca gatttcatct gctgtcaatc ggtgaaaatg tgaaggattc gtttcttctt
    55981 aataagaaat aaatactggt ataaagcgcc cttcccttac cagcaaggtt tatagtgtct
    56041 gaagtttttt ttgtttgtct aaaatagcca ccttcaacat ggggagctaa ctctagagtt
    56101 cttatcaagt cttctttatc cgtcggagcc aatgggttga agtaactctt gttcaaagtg
    56161 gtgttacgat ttcaagaact cctctcagtt ctgaggacac ggtaatgatt gatgcgacgg
    56221 aagtacaaat caatcgccct aaaagaagaa ttagcgaatg attctggtaa aaaaaatgcc
    56281 acgctatgaa ggctcaagcg attgtcacaa gtcaagggag aattgtttct ttggatatcg
    56341 ctgtgaacta ttgtcatgat atgaagttgt tcaaaatgag tcgcagaaat atcggacaag
    56401 ctggtaaaat cttggctgac agtggttatc aagggctcat gaagatatat cctcaagcac
    56461 aaactccacg taaatccagc aaactcaagc cactaacagt tgaagataaa gcctataacc
    56521 atgcgctatc caaggagaga agcaaggttg agaacatctt tgccaaagta aaaacgttta
    56581 aaatgttttc aacaacctat cgaaatcatc gtaaacgctt cggattacga atgaatttga
    56641 ttgctggtat tatcaatcat gaactaggat tctagttttg caggaagtct attatttggt
    56701 taggtgaatt agtgaagtgt ttaggcaagt gtctctggtt acgacgtcat ggcctctaaa
    56761 tcgattatat ttagaggcca tgactagtga agcagttagc tagttcgcat ataagcggct
    56821 agcgtctaac aattaggaac tttagttcca ataactttaa gattacgacg ttttaggaca
    56881 taaatcgatc atatttatgt cctaaaacta gtgaagcgcc tagccaaagt ccgaatagga
    56941 tttggcgtta gttacttaga ttgctttgca atcaagtaac tttggcgatt tacatcttct
    57001 ctggcgcttc tactccaagc aagcgaaggg cttctttgag aacgactgcg gttgcgtagc
    57061 tgagggctag acggctgtcg cgttctgggc tttcatccaa gatacgtgta tgtgcatagt
    57121 atttgttaaa ggattgagcc aggctaattg caaatttagc aatgatagaa ggttcaaagt
    57181 tatctgccgc acggttgata atacgtggga agtcttgaat gagtttaatg atttcccagc
    57241 tttcagtatc attcaagcta tagttgccag ctgtttctgg tttgaaatcg gctttgcgta
    57301 agatagattg gatacgagcg taggcatatt gaacgtaagg tccagtttca ccctcgaagg
    57361 ataccatagc ttctaggtcg aagtcgtatc catttgtacg gtcggttttg aggtcataga
    57421 atttaatggc tccaacccca acagcatgtg ctacttggtc tttgttttct agttcaggat
    57481 ttttagcctc gatttggacc ttggcacggc taacagcctc tgcaacagta ggctctagca
    57541 agatgacatt ccctttacga gtagagagtt tcttcccttc ttttgtaacc aaaccaaaag
    57601 gaacgtgagt aatgtcgtca ctccagtcgt agcccatctc ttgcaagaca gctttgagct
    57661 gtttaaagtg ggcagattgt tcttgaccaa cgacatagat agatttagca aattggtatt
    57721 cgtttttacg gtaaagggct gcagccaagt cacgtgtgat atagagagtt gcaccatcag
    57781 atttcttgat gagggctgga tgttcaattc cgtatttctc aagattgaca acttgggcac
    57841 cttctgattc aagaagtagt cctttttcag aaagaatgtc tacaactgca tccatcttat
    57901 cattgtagaa ggcttctccg ttatagctgt caaattcaac cttcaattca ttgtaaaggc
    57961 ggttaaattc cactaaactt tcatcgcgga accattgcca aagagcgaga gcttcctcat
    58021 ctccattttc aagtttacgg aaccattcgc gcgcttcttc atccaagcta gggtcatttt
    58081 cagcttcagc gttgatgcgg acatagagtt taaggagttc atcgattgga tgagctttta
    58141 cagcttcttc gtcgccccat tttttgtagg caacaatcaa catcccaaat tgtttacccc
    58201 agtctcccaa atggttgacc ttgaccgttt gataaccgat tttttggaaa atatgtgaca
    58261 agctatctcc gataacagtt gaacgcaggt ggccaataga aaatggttta gcgatattcg
    58321 gactagacat gtcgataaca acattttctt gtttgccaat attttggtca gcatagtgtt
    58381 ctttttcagt ggtaacagct tgcaatactt gagcagaaat ggcagattta tcaaggaaaa
    58441 agttaacgta aggtcctgtt gcgacaactt tttcaaaggc ttggctgttc attttttcag
    58501 ccagttcagc cgcaatcatt tgtggtgctt tacgttcgac ttttgcaaga gaaaaagcag
    58561 ggaaagcaat gtctcccatt tctgagtttt taggggtttc cagtaacttt aaaatagcct
    58621 cttggtccag gctatcaatg atgctagata attcgctagc aatcaattct tttgtattca
    58681 ttaagagctc ctttttggac ttttctacta ttttatcaca attttaaaga aagaagaaaa
    58741 aatttttgaa atctcctgtt tttttggtat aatatggtta taaatatagt tataaatatg
    58801 cacgcaagag gattttatga gaaaaagaga tcgtcatcag ttaataaaaa aaatgattac
    58861 tgaggagaaa ttaagtacac aaaaagaaat tcaagatcgg ttggaggcgc acaatgtttg
    58921 tgtgacgcag acaaccttgt ctcgtgattt gcgcgaaatc ggcttgacca aggtcaagaa
    58981 aaatgatatg gtgtattatg tactagtaaa tgagacagaa aagattgatt tggtggaatt
    59041 tttgtctcat catttagaag gtgttgcaag agcagagttt accttggtgc ttcataccaa
    59101 attgggagaa gcctctgttt tggcaaatat tgtagatgta aacaaggatg aatggatttt
    59161 aggaacagtt gctggtgcca ataccttatt ggttatttgt cgagatcagc acgttgccaa
    59221 actcatggaa gatcgtttgc tagatttgat gaaagataag taaggtcttg ggagttgctc
    59281 tcaagactta tttttgaaaa ggagagacag aaaatggcga tagaaaagct atcacccggc
    59341 atgcaacagt atgtggatat taaaaagcaa tatccagatg cttttttgct ctttcggatg
    59401 ggtgattttt atgaattatt ttatgaggat gcggtcaatg ctgcgcagat tctggaaatt
    59461 tccttaacga gtcgcaacaa gaatgccgac aatccgatcc ctatggcggg tgttccctat
    59521 cattctgccc aacagtatat cgatgtcttg attgagcagg gttataaggt ggctatcgca
    59581 gagcagatgg aaaatcctaa acaagcagtt ggggttgtta aacgagaggt tgttcaggtc
    59641 attacgccag ggacagtggt cgatagcagt aagccggaca gtcagaataa ttttttggtt
    59701 gccatagacc gcgaaggcaa tcaatttggc ctagcttata tggatttggt gacgggtgac
    59761 ttttatgtga caggtctttt ggatttcacg ctggtttgtg gggaaatccg taacctcaag
    59821 gctcgagaag tggtgttggg ttatgacttg tctgaggaag aagaacaaat cctcagccgc
    59881 cagatgaatc tggtactctc ttatgaaaaa gaaagctttg aagaccttca tttattggat
    59941 ttgcgattgg caacggtgga gcaaacggca tctagtaagc tgctccagta tgttcatcgg
    60001 actcagatga gggaattgaa ccacctcaaa cctgttatcc gatacgaaat taaggatttc
    60061 ttgcagatgg attatgcgac caaggctagt ctggatttgg ttgagaatgc tcgctcaggt
    60121 aagaaacaag gcagtctttt ctggcttttg gatgaaacca aaacggctat ggggatgcgt
    60181 ctcttgcgtt cttggattca tcgccccttg attgataagg aacgaatcgt ccaacgtcaa
    60241 gaagtagtgc aggtctttct cgaccatttc tttgagcgta gtgacttgac agacagtctc
    60301 aagggtgttt atgacattga gcgcttggct agtcgtgttt cttttggcaa aaccaatcca
    60361 aaggatctct tgcagttggc gactaccttg tctagtgtgc cacggattcg tgcgatttta
    60421 gaagggatgg agcaacctac tctagcctat ctcatcgcac aactggatgc aatccctgag
    60481 ttggagagtt tgattagcgc agcgattgct cctgaagctc ctcatgtgat tacagatggg
    60541 ggaattatcc ggactggatt tgatgagact ttagacaagt atcgttgcgt tctcagagaa
    60601 gggactagct ggattgctga gattgaggct aaggagcgag aaaactctgg tatcagcacg
    60661 ctcaagattg actacaataa aaaggatggc tactattttc atgtgaccaa ttcgcaacta
    60721 ggaaatgtgc cagcccactt tttccgcaag gcgacgctga aaaactcaga acgctttgga
    60781 accgaagaat tagcccgtat cgagggagat atgcttgagg cgcgtgagaa gtcagccaac
    60841 ctcgaatacg aaatatttat gcgcattcgt gaagaggtcg gcaagtacat ccagcgttta
    60901 caagctctag cccaaggaat tgcgacggtt gatgtcttac agagtctggc ggttgtggct
    60961 gaaacccagc atttgattcg acctgagttt ggtgacgatt cacaaattga tatccggaaa
    61021 gggcgccatg ctgtcgttga aaaggttatg ggggctcaga cctatattcc aaatacgatt
    61081 cagatggcag aagataccag tattcaactg attacagggc caaacatgag tgggaagtct
    61141 acctatatgc gtcagttagc catgacggcg gttatggccc agctgggttc ctatgttcct
    61201 gctgaaagcg cccatttacc gatttttgat gcgattttta cccgtatcgg agcagcagat
    61261 gacttggttt cgggtcagtc gacctttatg gtggagatga tggaggccaa taatgccatt
    61321 tcgcatgcga ccaagaactc tctcattctc tttgatgaat tgggacgtgg aactgcaact
    61381 tatgacggga tggctcttgc tcagtccatc atcgaatata tccatgagca catcggagct
    61441 aagaccctct ttgcgaccca ctaccatgag ttgactagtc tggagtctag tttacaacac
    61501 ttggtcaatg tccacgtggc aactctggag caggatgggc aggttacctt ccttcacaag
    61561 attgaaccgg gaccagctga taaatcctac ggtatccatg ttgccaagat tgctggcttg
    61621 ccagcagacc ttttagcaag ggcggataag attttgactc agctagagaa tcaaggaaca
    61681 gagagtcctc ctcccatgag acaaactagt gctgtcactg aacagatttc actctttgat
    61741 agggcagaag agcatcctat cctagcagaa ttagctaaac tggatgtgta taatatgaca
    61801 cctatgcagg ttatgaatgt cttagtagag ttaaaacaga aactataaaa ccaagactca
    61861 ctagttaatc tagctgtatc aaggagactt ctttgacaat tctccacttt tttgctagaa
    61921 taacatcaca caaacagaat gaaaaggagc tgacgcattg tcgctccctt ttgtctattt
    61981 tttaaggaga aagtatgctg attcagaaaa taaaaaccta caagtggcag gccctggctt
    62041 cgctcctgat gacaggcttg atggttgcta gttcacttct gcaaccgcgt tatctgcagg
    62101 aagtcttagg cgccctcctt actgggaaat atgaagctat ttatagtatc ggggcttggt
    62161 tgattggtgt ggccgtagtc ggtctagttg ctggtggact caatgttgtc ctcgcagcct
    62221 atattgccca aggagtttca tccgaccttc gggaggatgc cttccgtaaa attcaaacct
    62281 tttcttatgc tgatattgaa caatttaatg cgggaaatct agtcgttcga atgacaaatg
    62341 atatcaacca gattcagaac gttgtcatga tgaccttcca aattcttttc agacttcccc
    62401 tcttgttcat cggttcgttt atcctagcgg ttcaaacctt accttctctg tggtgggtga
    62461 ttgttctcat ggtagtcttg atttttggtt tgactgctgt catgatggga atgatggggc
    62521 ctcgttttgc caagtttcaa acccttcttg agcgcatcaa tgccattgcc aaggaaaatt
    62581 tacgtggcgt tcgtgtggtc aagtcctttg tccaagaaaa agagcaattt gctaagttta
    62641 cagaggtctc agacgagctt cttggtcaaa acctttacat tggttatgcc ttttcagtag
    62701 tggaaccctt tatgatgttg gttggttacg gggcggtctt cctctctatt tggctggtcg
    62761 cgggaatggt tcagtcggat ccgtctgttg ttggttccat cgcttctttt gttaattacc
    62821 taagccagat tatctttacc attgttatgg ttggattttt gggaaattct gtcagccgtg
    62881 ccatgatttc catgcgtcgt attcgagaaa ttcttgacgc agagccagct atgaccttca
    62941 aggatatccc agatgaagag ttggttggaa gccttagctt tgaaaatgtg acctttacct
    63001 atccaatgga caaggaaccg atgctgaaag atgtgagctt tactattgaa cctggtcaaa
    63061 tggttggtgt agttggagcg actggtgcag gaaagtcaac cttggctcaa ttgattccac
    63121 gtctctttga tccacaggaa ggggctatca aaatcggagg taaggatatt cgagaagtga
    63181 gtgaagggac cctgcgtaaa acagtttcca tcgttctcca acgtgccatt ctttttagtg
    63241 gaacgattgc agataacttg agacagggga agggaaatgc tactctattt gaaatggagc
    63301 gcgcagccaa tattgcccag gctagtgaat tcattcatcg tatggagaaa acctttgaaa
    63361 gtccagttga agaacgggga accaatttct ctggtggaca aaaacaaagg atgtcgattg
    63421 cgcgtgggat tgtcagcaat ccacgtattc tgatttttga tgattcgacc tcagccttgg
    63481 atgccaaatc agagcgcttg gtgcaagaag ctttgaataa ggacttgaag gggacgacaa
    63541 ctattattat tgctcaaaaa attagctcgg ttgtccatgc agacaagatc ttggttctaa
    63601 atcaaggacg attgattggt caaggcacgc atgcagactt ggttgccaac aatgccgttt
    63661 accgtgaaat ctatgaaaca cagaaatgaa agacaaacta taagaaaagt caatagtttt
    63721 atctaaacta tttcttattt caatttgatg atttggcgat gattttagag cacggcaaaa
    63781 agcccttgaa aaagtccatt ttttcaaagg taatcctgtg ttaatttcag aaattacatc
    63841 actttttgtt cgtcaaatgg cagctctttt ttaggatata aaacagggtt cggataagtt
    63901 tttttgcaag gtggatgatg gctacattgt aatgttttcc ttgttctaac ttagtcttaa
    63961 gataggtctt aaaagcaggt gaaaagcgag ggcatgcttt ggcagcttgt atgagtacct
    64021 accgcagatg aggggaaccc cgtttgacca ttcttccagc taaatcaatc tgacctgact
    64081 gataaataga agaatccagt ccagcgaaag cttgtaattg agcaggatta tcaaaggcat
    64141 gaatatttcg aatctcggct aaaatgaccg cccctaaacg attctcaatc ccagtaaccg
    64201 tcgtgatgac cgagttgaac tcagccatca agtcattgac acatgtttcc gccttgtcaa
    64261 tgagcctctt gtaatgtttg atgttttcat tacacgagat aaaacgtcta tgcgttatca
    64321 aactcattac caattaaaac aaaaagctgt ggttagatcc tttcggaaat tgtcaagcga
    64381 ttggaggaaa tgaactaatc cacagcggct tattccaagt ataccacttg ggctttggca
    64441 gtagctaact gcgctaaata taatataagg aggagtaaaa tgaagacagt tcaatttttt
    64501 tggcattatt ttaaggtcta caagttctca tttgtagttg tcatcctgat gattgttctg
    64561 gcgacttttg cccaagccct ctttccagtc ttttctggac aagcggtgac gcagctagcc
    64621 aatttagttc aagcttatca aaatggcaat ccagaacttg tatggcaaag cctatcagga
    64681 atcatggtca atcttggcct gctggttttg gttctattta tctctagtgt aatatacatg
    64741 tgtctcatga cgcgcgtgat tgcagaatcg accaacgaga tgcgcaaagg cctctttggt
    64801 aagcttgctc agttgacggt ttctttcttt gaccgtcgac aagatggcga tatcctgtct
    64861 cattttacca gtgatttgga taatatcctc caagccttta acgaaagctt gattcaggtc
    64921 atgagcaata ttgttttata cattggtctg attcttgtca tgttttcgag aaatgtgacg
    64981 ctggctctca tcaccattgc cagcacccca ttggctttcc ttatgctgat tttcatcgtg
    65041 aaaatggcac gcaaatacac caacctccag cagaaagagg tagggaagct caacgcctat
    65101 atggatgaga gcatctcagg ccaaaaagcc gtgattgtgc aaggaattca agaggatatg
    65161 atggcaggat ttcttgaaca aaatgagcgc gtgcgcaagg caacctttaa aggaagaatg
    65221 ttctcaggaa ttcttttccc tgtcatgaat gggatgagcc tgattaatac agccatcgtc
    65281 atctttgctg gttcggctgt acttttgaat gataagtcta ttgaaacaag tacagcccta
    65341 ggtttgattg ttatgtttgc acaattttca cagcagtact accagcctat tatccaagtt
    65401 gcagcgagtt ggggaagcct tcagttggcc tttactggag ctgaacgaat tcaggaaatg
    65461 tttgatgcag aggaggaaat ccgacctgaa aaggctccaa ccttcactaa gttgcaagaa
    65521 agtgttgaaa tcagtcatat cgatttttca tacttgcctg ataaacctat tttgaaagat
    65581 gtcagcattt ctgcccctaa aggccagatg acagcagttg ttgggccgac aggttcagga
    65641 aaaacgacta ttatgaacct catcaatcgc ttttatgatg ttgatgctgg tggtatttat
    65701 tttgatggta aagacattcg tggctatgac ttagatagtc ttagaagcaa ggtgggaatt
    65761 gtattgcaag attcggtctt gtttagcgga acgattagag acaatatccg atttggtgtg
    65821 ccagatgcta gtcaggaaat ggttgaggta gcagcaaaag caacccacat tcacgactat
    65881 atcgaaagtt tgcctgataa gtacgatact cttattgatg atgaccagag catcttttca
    65941 acagggcaga agcaattgat ttcaatcgct cgaaccctga tgacagatcc agaagttctc
    66001 attctcgatg aagcaacttc aaacgtagat acggtgacag aaagcaagat tcagcatgcc
    66061 atggaggtgg ttgtagcagg tagaactagt ttcgtcattg cccaccgctt gaaaaccatt
    66121 ctcaatgcag atcagattat tgtccttaaa gatggagaag tcattgaacg tggtaaccac
    66181 catgaacttt tgaagctagg tggcttttat tcagaactct atcacaatca atttgttttc
    66241 gaataagaaa gaagttgtcc tatgtgggca gctttttctt gtccataaaa aatgtttatc
    66301 acagccttaa aaaaaacata ttagacgaaa gtcgttttga gtgatatgat aggactatcg
    66361 ttagcattcg aaaggagagg catcatggct agaacggttg taggagttgc tgcaaatcta
    66421 tgtcccgtag acgcagaagg caaaatcatt cattcatctg tatcttgtag attcgcagag
    66481 atcattcgtc aagtcggtgg tctcccttta gtcattcctg ttggtgatga gtcagttgta
    66541 cgtgattatg tggaaatgat tgacaaactc attttgacag gaggccaaaa tgttcatcct
    66601 cagttttatg gagagaaaaa gaccgtcgaa agcgatgatt acaatctggt ccgtgacgaa
    66661 tttgaattgg cactcttgaa ggaagcgctt cgtcagaata aaccaattat ggcaatctgt
    66721 cgcggtgtcc aacttgtcaa tgttgccttt ggtggaaccc tcaatcaaga aatcgaaggt
    66781 cactggcaag gactaccttt cgggacatct cactctattg agacagtaga aggaagcgtg
    66841 gtggctaagc tatttgggaa agaaagtcag gtcaactcag tccatcgtca aagcattaaa
    66901 gatttggcac ctaatttccg tgtaactgct attgattcaa gagaccaaac tattgaagcg
    66961 attgagtcta tcgacgagca ccgcattatc ggtttacagt ggcatccaga gtttctggtt
    67021 aatgaagaag atggcaattt agaattattt gagtatttat tgaatgaact gtaacgattg
    67081 gaacatctgg tcgttctttc ttttattttt tcaaaatttt tagaatgtgg cattttacgc
    67141 aaacgtttga attctgataa aaattggaga aattcgacaa aaaaacttga aaaaaacgaa
    67201 ggtaagcgtt atgatagaaa agaagaaata ttggaggaag aacatgtcac atattaaatt
    67261 tgattattca aaagttttag acaaatttgt tgcaccacat gaagtggaat acatgcaatc
    67321 acaagtaaca gcagcagatg aattgatccg taaaggaact ggtgctggta gcgacttctt
    67381 gggatggttg gaccttcctg aaaaatacga ccgcgaagaa tttgaccgca tcttgaaagc
    67441 tgctgagcaa atcaagtcag acagcgatgt tttggttgtg atcggtattg gtggatctta
    67501 ccttggtgca aaagcagcaa tcgacttctt gaatcaccat tttgctaact tgcaaacaaa
    67561 agaagaacgc aaagctccac aaatccttta cgcaggaaac tcaatctcat ctacttacct
    67621 tgctgacttg gtagagtatg ttgcagacaa ggacttctca gtaaacgtaa tttctaaatc
    67681 aggtacaaca actgaaccag cgattgcttt ccgtgtcttt aaagaactct tggttaagaa
    67741 atacggtcaa gaagaagcta acaaacgtat ctatgcaaca actgaccgcc aaaagggtgc
    67801 tgttaaggtt gaagcagacg ctaacggttg gggaacattt gttgttccag atgatatcgg
    67861 cggacgcttc tcagtattga cagccgttgg tttgcttcca atcgcagcat caggagctga
    67921 catcaaagct cttatggaag gtgcgaatgc agctcgcaaa gactacactt cagacaaaat
    67981 ctctgaaaac gaagcttacc aatacgcagc cgttcgtaac atcctttatc gtaaaggcta
    68041 tgcaactgag atcttggtaa actatgagcc atcacttcaa tacttctcag aatggtggaa
    68101 acaattggct ggtgaatcag aaggaaaaga ccaaaaaggt atctacccaa cttcagccaa
    68161 cttctcaact gacttgcact cacttggtca atttatccaa gaaggaactc gtatcatgtt
    68221 tgaaacagtt gtccgtgttg acaaacctcg taaaaacgtg cttattccta ctttggaaga
    68281 agaccttgac ggacttggtt accttcaagg aaaagacgtt gactttgtaa acaaaaaagc
    68341 aactgacggt gttcttcttg cccacacaga tggtgatgta ccaaacatgt atgtgactct
    68401 tccagagcaa gacgctttca ctcttggtta cactatctac ttcttcgaat tggcaattgc
    68461 cctttcaggt tacttgaatg ctatcaaccc atttgaccaa ccaggtgttg aagcttataa
    68521 acgtaacatg tttgcccttc ttggaaaacc aggatttgaa gaattgagca aagaacttaa
    68581 cgcacgtcta taatagaaga aaagagtggt ttgcccactc tttttactct ctttatccat
    68641 agaaattgga ctcagccaag acttgtgata taatatagaa agcaaaaagg cagacgccta
    68701 gataatagga gaaactatgt caaaagatat ccgcgtacgt tacgcaccaa gtccaacagg
    68761 actactacac atcggaaatg ctcgtacagc attgtttaat tacttgtatg cgcgccatca
    68821 tggtggaaca tttctcatcc gtatcgaaga tactgaccgt aaacgccatg tcgaggatgg
    68881 tgaacgttca caacttgaaa accttcgctg gttaggcatg gattgggatg aaagtccaga
    68941 atcatatgag aattatcgcc agtctgagcg tttagacttg tatcaaaaat acattgacca
    69001 actattagct gaaggaaaag cctataaatc ttacgttaca gaagaagagt tggcagctga
    69061 acgcgaacgc caagaagcag ctggcgaaac accacgctac atcaatgaat accttggtat
    69121 gagtgaagaa gaaaaagcag cttacatcgc agaacgtgaa gcagcaggga tcatcccaac
    69181 tgttcgtttg gctgtcaatg agtcaggtat ctacaagtgg catgatatgg tcaaaggcga
    69241 tatcgaattt gaaggtggca atatcggtgg tgactggatt atccaaaaga aagacggtta
    69301 cccaacttac aactttgccg ttgccatcga tgaccatgat atgcaaatct cccatgttat
    69361 ccgtggagac gaccatattg ctaacacacc aaaacagctc atggtttatg aagcacttgg
    69421 ttgggaagct ccagagtttg gtcacatgac cttgattatc aactctgaga ctggtaagaa
    69481 gttatctaaa cgtgatacta atacacttca atttatcgaa gattaccgaa agaaaggtta
    69541 ccttccagaa gcagtcttta attttattgc tcttcttggt tggaacccag gtggtgaaga
    69601 tgagattttc tctcgtgaag aactcattaa actttttgat gaaaaccgcc tcagcaagtc
    69661 accagcagcc tttgatcaga aaaaattaga ctggatgagc aatgattata tcaagaatgc
    69721 agaccttgaa accatctttg aaatggcaaa accattctta gaggaagcag gccgtttgac
    69781 tgacaaggct gaaaaattag ttgagctcta taaaccacaa atgaaatcag tagatgagat
    69841 tatcccattg acagatcttt tcttctcaga tttcccagaa ttgacagaag cagagcgcga
    69901 agtcatgacg ggtgaaacag ttccaacagt tcttgaagca ttcaaagcaa aacttgaagc
    69961 gatgacagat gatgaatttg tgacagaaaa tatcttccca caaattaaag cagtccaaaa
    70021 agaaacaggt attaaaggga aaaatctttt catgcctatt cgtatcgcag tttcaggcga
    70081 aatgcatggg ccagaattac cagatacaat tttcttgctt ggacgtgaaa aatcaattca
    70141 gcatatcgaa aacattctaa aagaaatctc taaataaaga ggatacaata atggacatct
    70201 gggaaaagat gtacgaagaa gcacagaaac tatacaatcc acatgaagta tcagactttg
    70261 tttatgccaa tcatgttgta gctgcagtag aagcaggaga tggacaaata tttacaggat
    70321 tctgtatgga gggaacctgt ggtgttttcc atctctgcgc agaacgggcg gccctcttca
    70381 atatgtacca attttcagga caaactaagg ttaagaaagt attagccttt cgagataaac
    70441 caccttatgg tggaagttca gccatgcctt gcggtgcttg tagagaattc cttttagagc
    70501 ttaatgctga aaataaagat gcagaattca tgatggacta taatataaga aaaacagtta
    70561 aagtctcaga actaatccct tattggtggg gagaagaacg tgcttctaag tttaatgagc
    70621 gatagaagag tcagtataat tctggctctt tttactataa attgaaaaaa t
//
LOCUS       DAVLHC010000003        67524 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.003, whole genome shotgun sequence.
ACCESSION   DAVLHC010000003 DAVLHC010000000
VERSION     DAVLHC010000003.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 67524)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 67524)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..67524
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.003"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(1..297)
                     /locus_tag="VXE25_000178"
     CDS             complement(1..297)
                     /locus_tag="VXE25_000178"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000239014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0770713.1"
                     /translation="MVKINKICSIQGSSVENEDIVGSQNQYFWIIGGATDLYNSKEEI
                     GYSVSEVVHILSESLSVNCKESKTLKQIFETALLEVKDEIGLNSYELTEYSKMK"
     gene            complement(281..2440)
                     /gene="pfbA"
                     /locus_tag="VXE25_000179"
     CDS             complement(281..2440)
                     /gene="pfbA"
                     /locus_tag="VXE25_000179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010976622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multi-ligand-binding adhesin PfbA"
                     /protein_id="HEV0770714.1"
                     /translation="MLKIVKKLEVLMKYFVPNEVFSIRKLKVGTCSVLLAISILGSQG
                     ILSDEVVTSSSPMATKESSNAITNDLDNSPTVNQNRSAEMIASNSTTNGLDNSLSVNS
                     ISSNGTIRSNSQLDNRTVESTVTSTNENKSYKEDVISDRIIKKEFEDTALSVKDYGAV
                     GDGIHDDRQAIQDAIDAAAQGLGGGNVYFPEGTYLVKEIVFLKSHTHLELNEKATILN
                     GINIKNHPSIVFMTGLFTDDGAQVEWGPTEDISYSGGTIDMNGALNEEGTKAKNLPLI
                     NSSGAFAIGNSNNVTIKNVTFKDSYQGHAIQIAGSKNVLVDNSRFLGQALPKTMKDGQ
                     IISKESIQIEPLTRKGFPYALNDDGKKSENVTIQNSYFGKSDKSGELVTAIGTHYQTL
                     STQNPSNIKILNNHFDNMMYAGVRFTGFTDVLIKGNRFDKKVKGESVHYRESGAALVN
                     AYSYKNTKDLLDLNKQVVIAENIFNIADPKTKAIRVAKDSAEYLGKVSDITVTKNVIN
                     NNSKETEQPNIELLRVSDNLVVSENSIFGGKEGIVIEDSKGKITVLNNQFYNLSGKYI
                     SFIKSNANGKEPVIRDSDGNFNIVTENGLYNIVTNNLSDKNEKEKNKEEKQSNSNNVI
                     DSNQKNGEFNSSKDNRQMNDKIDNKQDNKTEEVNYKIVGDGRETENHINKSKEIVDVK
                     QKLPKTGSNKIMELFLTVTGIGLLLTLKGLKYYGKDK"
     gene            complement(3570..4796)
                     /locus_tag="VXE25_000180"
     CDS             complement(3570..4796)
                     /locus_tag="VXE25_000180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001134527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegT/DnrJ/EryC1/StrS aminotransferase family
                     protein"
                     /protein_id="HEV0770715.1"
                     /translation="MPNYNIPFSPPDITEAEIAEVADTLRSGWITTGPKTKELERRLS
                     LYTQTPKTVCLNSATAALELILRVLEVGPGDEVIVPAMTYTASCSVITHVGATPVMVD
                     IQADTFEMDYDLLEQAITEKTKVIIPVELAGIVCDYDRLFQVVEKKRDFFTASSKWQK
                     AFNRIVIVSDSAHALGSTYKGQPSGSIADFTSFSFHAVKNFTTAEGGSATWKANPVID
                     DEEMYKEFQILSLHGQTKDALAKMQLGSWEYDIVTPAYKCNMTDIMASLGLVQLDRYP
                     SLLQRRKDIVDRYDSGFAGSRIHPLAHKTETVESSRHLYITRVEGASLEERNLIIQEL
                     AKAGIASNVHYKPLPLLTAYKNLGFDMTNYPKAYAFFENEITLPLHTKLSDEEVDYII
                     ETFKTVSEKVLTLSKK"
     gene            complement(4839..5531)
                     /locus_tag="VXE25_000181"
     CDS             complement(4839..5531)
                     /locus_tag="VXE25_000181"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000922225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar transferase"
                     /protein_id="HEV0770716.1"
                     /translation="MLKWEDLPVEMKSSEVESYYQLVSKRKGSLIFKRCLDWVLALVL
                     LVLTSPIFLILSIWIKLDSKGPVIYKQERVTQYNCRFKIWKFRTMVTDADKKGSLVTS
                     ANDSRITKVGNFIRRVRLDELPQLVNVLKGEMSFVGTRPEVPRYTEQYSPEMMATLLL
                     QAGITSPASINYKDEDTIISQMTEKGLSVDQAYVEHVLPEKMRYNLAYLREFSFFGDI
                     KIMFQTVFEVLK"
     gene            complement(5704..7455)
                     /locus_tag="VXE25_000182"
     CDS             complement(5704..7455)
                     /locus_tag="VXE25_000182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001180175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0770717.1"
                     /translation="MQNKQEQWAVLKRLMSYLKSYGLLIFLALSFLLATTVIKSVIPL
                     VASHFIDQYLSNLNQLAVTVLLVYYGLYILQTVVQYVGNLLFARVSYSIVRDIRRDAF
                     ANMEKLGMSYFDKTPAGSIVSRLTNDTETISDMFSGILSSFISAVFIFLTTLYTMLVL
                     DFRLTALVLLFLPLIFLLVNLYRKKSVKIIEKTRSLLSDINSKLAENIEGIRIIQAFN
                     QEKRLQAEFDEINQEHLVYANRSVALDALFLRPAMSLLKLLGYAVLMAYFGYRGFSIG
                     ITVGTMYAFIQYINRLFDPLIEVTQNFSTLQTAMVSAGRVFALIDERTYEPLQENGQA
                     KVQEGNIRFEHVCFSYDGKHPILDDISFSVNKGETIAFVGHTGSGKSSIINVLMRFYE
                     FQSGRVLLDDVDIRDFSQEELRKNIGLVLQEPFLYHGTIKSNIAMYQEISDEQVQAAA
                     AFVDADSFIQELPQGYDSPVSERGSSFSTGQRQLLAFARTVASQPKVLILDEATANID
                     SETESLVQASLAKMRQGRTTIAIAHRLSTIQDANCIYVLDKGRIIESGTHEELLALGG
                     TYHKMYSLQAGAMADTL"
     gene            complement(7445..9190)
                     /locus_tag="VXE25_000183"
     CDS             complement(7445..9190)
                     /locus_tag="VXE25_000183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000022567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEV0770718.1"
                     /translation="MSIIQKLWWFFKLEKRRYLVGIVALILVSVLNLIPPMVMGRVID
                     AITSGQLTQQDLLLSLFYLLLAAFGMYYLRYVWRMYILGTSYCLGQIMRSRLFKHFTK
                     MSSAFYQTYRTGDLMAHATNDINALTRLAGGGVMSAVDASITALVTLLTMLFSISWQM
                     TLVAILPLPFMAYATSRLGRKTHKAFGESQAAFSELNNKVQESVSGIKVTKSFGYQAD
                     ELKSFQAVNELTFQKNLQTMKYDSLFDPMVLLFVGSSYVLTLLVGSLMVQEGQITVGN
                     LVTFISYLDMLVWPLMAIGFLFNTTQRGKVSYQRIENLLSQESPVQDPEFPLDGIENG
                     RLEYAIDSFAFENEETLTDIHFSLAKGQTLGLVGQTGSGKTSLIKLLLREYDVDKGAI
                     YLNGHDIRDYRLTDLRSLMGYVPQDQFLFATSILDNIRFGNPNLPLSAVEEATKLARV
                     YQDIVDMPQGFDTLIGEKGVSLSGGQKQRLAMSRAMILNPDILILDDSLSAVDAKTEY
                     AIIDNLKETRKDKTTIITAHRLSAVVHADFILVLQNGQIIERGRHEDLLAMDGWYAQT
                     YQSQQLEMKGEEDAE"
     gene            complement(9396..9773)
                     /locus_tag="VXE25_000184"
     CDS             complement(9396..9773)
                     /locus_tag="VXE25_000184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000825490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF421 domain-containing protein"
                     /protein_id="HEV0770719.1"
                     /translation="MKRLIDGKPTLLIKNGNIDPEACRSVGLSASDVSLKLRSQGIFQ
                     MKQVKRAVQEQNGQLIVVQMGDENPKYPVVTDGVIQVDVLESIGRSEEWLLDNLSKQG
                     HDNVANIFIAEYDKGAVTVVTYE"
     gene            complement(9845..10301)
                     /locus_tag="VXE25_000185"
                     /pseudo
     CDS             complement(9845..10301)
                     /locus_tag="VXE25_000185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730499.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3290 family protein"
     gene            10435..11262
                     /gene="xth"
                     /locus_tag="VXE25_000186"
     CDS             10435..11262
                     /gene="xth"
                     /locus_tag="VXE25_000186"
                     /EC_number="3.1.11.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006596696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease III"
                     /protein_id="HEV0770720.1"
                     /translation="MKLISWNIDSLNAALTSDSARAKLSQEVLQTLVAENADIIAIQE
                     TKLSAKGPTKKHVEILEELFPGYENTWRSSQEPARKGYAGTMFLYKKELTPTISFPEI
                     GAPSTMDLEGRIITLEFDAFFVTQVYTPNAGDGLKRLEERQVWDVKYAEYLAELDKEK
                     PVLATGDYNVAHNEIDLANPASNRRSPGFTDEERAGFTNLLATGFTDTFRHVHGDVPE
                     RYTWWAQRSKTSKINNTGWRIDYWLTSNRIADKVTKSDMIDSGARQDHTPIVLEIDL"
     gene            11274..11372
                     /locus_tag="VXE25_000187"
     CDS             11274..11372
                     /locus_tag="VXE25_000187"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glyoxalase"
                     /protein_id="HEV0770721.1"
                     /translation="MDYNAVIPEFLVSNIEQSRSFYCGLLGFRIEY"
     gene            11417..11656
                     /locus_tag="VXE25_000188"
     CDS             11417..11656
                     /locus_tag="VXE25_000188"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glyoxalase"
                     /protein_id="HEV0770722.1"
                     /translation="MLEEGTKDQLAELTYPFGRGVNLSFGIKDVPKLYQKVMEANYPI
                     YRLLTKRKFRVSDPYIYPHKFAVLDPDGYFLRFSE"
     regulatory      12039..12134
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00167"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="purine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="guanine and/or adenine"
                     /db_xref="RFAM:RF00167"
     gene            12534..13115
                     /locus_tag="VXE25_000189"
     CDS             12534..13115
                     /locus_tag="VXE25_000189"
                     /EC_number="2.4.2.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000770427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="xanthine phosphoribosyltransferase"
                     /protein_id="HEV0770723.1"
                     /translation="MKLLEERILKDGHILDDNILKVDSFLTHQVDFSLMREIGKVFAE
                     KFAAAGITKVVTIEASGIAPAVFTAEALNVPMIFAKKAKNITMNEGILTAQVYSFTKQ
                     VTSTVSIAGKFLSPEDKVLIIDDFLANGQAAKGLIQIIEQAGATVQAIGIVIEKSFQD
                     GRDLLEKAGYPVLSLARLDRFENGQVLFKEADL"
     gene            13115..14377
                     /locus_tag="VXE25_000190"
     CDS             13115..14377
                     /locus_tag="VXE25_000190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001194492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine permease"
                     /protein_id="HEV0770724.1"
                     /translation="MQTQEKHSQAAVLGLQHLLAMYSGSILVPIMIATALGYSAEQLT
                     YLISTDIFMCGVATFLQLQLNKYFGIGLPVVLGVAFQSVAPLIMIGQSHGSGAMFGAL
                     IASGIYVVLVSGIFSKVANLFPSIVTGSVITTIGLTLIPVAIGNMGNNVPEPTGQSLL
                     LSAITVLIILLINIFTKGFIKSISILIGLVVGTAIAATMGLVDFSPVAVAPLVHVPTP
                     LYFGMPTFEISSIVMMCIIATVSMVESTGVYLALSDITKDPIDSTRLRNGYRAEGLAV
                     LLGGIFNTFPYTGFSQNVGLVKLSGIKKRLPIYYAAGFLVLLGLLPKFGALAQIIPSS
                     VLGGAMLVMFGFVSIQGMQILARVDFANNEHNFLIAAVSIAAGVGLNNSNLFVSMPTA
                     FQMFFSNGIFVASLLAIVLNAVLNHKKK"
     gene            complement(14428..14889)
                     /locus_tag="VXE25_000191"
     CDS             complement(14428..14889)
                     /locus_tag="VXE25_000191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000850937.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein DpnD"
                     /protein_id="HEV0770725.1"
                     /translation="MKTKQLVASEEVYDFLKVIWPDYETESRYDNLSLIVCTLSDPDC
                     VRWLSENMKFGDEKQLALMKEKYGWEVGDKLPEWLHSSYHRLLLIGELLESNLKLKKY
                     TVEITETLSRLVSIEAENPDEAERLVREKYKSCEIVLDADDFQDYDTSIYE"
     gene            complement(14886..15650)
                     /locus_tag="VXE25_000192"
     CDS             complement(14886..15650)
                     /locus_tag="VXE25_000192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418959.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type-2 restriction enzyme DpnI"
                     /protein_id="HEV0770726.1"
                     /translation="MELHFNLELVETYKSNSQKARILTEDWVYRQSYCPNCGNNPLNH
                     FENNRPVADFYCNHCSEEFELKSKKGNFSSTINDGAYATMMKRVQADNNPNFFFLTYT
                     KNFEVNNFLVLPKQFVTPKSIIQRKPLAPTARRAGWIGCNIDLSQVPSKGRIFLVQDG
                     QVRDPEKVTKEFKQGLFLRKSSLSSRGWTIEILNCIDKIEGSEFTLEDMYRFESDLKN
                     IFVKNNHIKEKIRQQLQILRDKEIIEFKGRGKYRKL"
     gene            complement(15831..16235)
                     /locus_tag="VXE25_000193"
     CDS             complement(15831..16235)
                     /locus_tag="VXE25_000193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000651202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PaaI family thioesterase"
                     /protein_id="HEV0770727.1"
                     /translation="MKDFHFDAISAFENYEIEKMRDGHVVVTTKVVNSSLNYYGNAHG
                     GYLFTLCDQISGLVVISLGLDGVTLQSSINYLKAGKLDDVLTIKGECVHQGRTTCVMD
                     VDITNQEGRNVCKATFTMFVTGQRSEERRVRI"
     gene            complement(16305..17786)
                     /locus_tag="VXE25_000194"
     CDS             complement(16305..17786)
                     /locus_tag="VXE25_000194"
                     /EC_number="2.7.7.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose--hexose-1-phosphate
                     uridylyltransferase"
                     /protein_id="HEV0770728.1"
                     /translation="MTLVDKFVTHVISESSFEEMDRIYLTNRVLARVGEGVLEVETNL
                     DKLIDLKAQLVEEAVRLETIEDSQTAREILGTELMDLVTPCPSQVNRDFWEAYAYSPE
                     QAIEDFYQLSQKNDYIKLKAIAKNIAYRVPSDYGELEITINLSKPEKDPKEIAVAKLV
                     QASNYPQCQLCLENEGYHGRVNHPARSNHRIIRFEMVGQEWGFQYSPYAYFNEHCIFL
                     DGQHRPMAISRQSFERLLAIVEQFPGYFAGSNADLPIVGGSILTHDHYQGGRHVFPME
                     LAPLQKTFRFAGFEQVKAGIIKWPMSVLRLTSDSKEDLINLADKIFQEWRQYSDSSVQ
                     ILAETDGTPHHTITPIARKRDGQFELDLVLRDNQTSAEHPDGIYHPHKDVQHIKKENI
                     GLIEVMGLAILPPRLKEEVEQVASYLVGEAVTVADYHQEWADQLKSQHPDLTDKEKAL
                     AIVKDSVGAIFVRVLEDAGVYKQTEQGQTAFMRFVEQVGISLD"
     gene            complement(17805..18983)
                     /locus_tag="VXE25_000195"
     CDS             complement(17805..18983)
                     /locus_tag="VXE25_000195"
                     /EC_number="2.7.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000189889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactokinase"
                     /protein_id="HEV0770729.1"
                     /translation="MAQHLTTEVLRKDFLAVFGQEADQTFFSPGRINLIGEHTDYNGG
                     HVFPAAISLGTYGAARKRDDQVLRFYSANFEDKGIIEVPLADLKFEKEHNWTNYPKGV
                     LHFLQEAGHVIDKGFDFYVYGNIPNGAGLSSSASLELLTGVVAEHLFDLKLERLDLVK
                     IGKQTENNFIGVNSGIMDQFAIGMGADQRAIYLDTNTLEYDLVPLDLKDNVVVIMNTN
                     KRRELADSKYNERRAECEKAVEELQVALDIQTLGELDEWAVDQYSYLIKDENRLKRAR
                     HAVLENQRTLKAQAALQAGDLETFGRLMNASHVSLEHDYEVTGLELDTLVHTAWAQEG
                     VLGARMTGAGFGGCAIALVQKDTVEAFKEAVGKHYEEVVGYAPSFYIAEVAGGTRVLD
                     "
     gene            19147..20154
                     /gene="galR"
                     /locus_tag="VXE25_000196"
     CDS             19147..20154
                     /gene="galR"
                     /locus_tag="VXE25_000196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000212522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding transcriptional regulator GalR"
                     /protein_id="HEV0770730.1"
                     /translation="MATLKDIAQLASVSIATVSRVLNRDQSLSVTEETRHRILTVAEE
                     LGYTKHLKTGESHKPKQKIAIIQWVSEQGELDDLYYYQIRLGIEKRAQELDYDILRYF
                     NDHPFTLSEEVIGILCIGKFSRAQISAFEEYQKPLVFLDSDTLSLGHTCIITDFYTAM
                     KQVVDYFLSQGMDRIGILTGLEETTDQEEIIQDKRLENFKNYSQARGIYHDELVFQGR
                     FTAQSGYDLMKEAIQSLGDQLPPAFFAASDSLAIGALRALQEAGISLPDRVSLISFND
                     TSLTKQVYPPLSSITVYTEEMGRAGMDILNKEVLHGRKIPSLTMLGTRLTLRESTLNQ
                     E"
     gene            complement(20200..21237)
                     /locus_tag="VXE25_000197"
     CDS             complement(20200..21237)
                     /locus_tag="VXE25_000197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000833740.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alcohol dehydrogenase catalytic
                     domain-containing protein"
                     /protein_id="HEV0770731.1"
                     /translation="MKSAVYTKAGQVGLASIERPQIIEADDVIIRVVRACVCGSDLWR
                     YRNPETKAGHKNSGHEAIGIVEEAGEAITTVKPGDFVIVPFTHGCGECDACLAGFDGS
                     CDNHIGNNLGGDFQAEYIRFHYANWALVKIPGQPSDYTEGMLKSLLTLADVMPTGYHA
                     ARVANVQKGDKVVVIGDGAVGQCAVIAAKMRGASQIILMSRHEDRQKMAMESGATAVV
                     AERGQEGITKVREILGGGADAALECVGTEAAIEQALGVLHNGGRMGFVGVPHYNNRAL
                     GSTFMQNISVAGGAASATTYDKQFLLKAVLDGDINPGRVFTSSYKLEDIDQAYKDMDE
                     RKTIKSMIVIE"
     gene            complement(21238..21591)
                     /locus_tag="VXE25_000198"
     CDS             complement(21238..21591)
                     /locus_tag="VXE25_000198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HEV0770732.1"
                     /translation="MNIKSASDLLGISADTIRYYERVGLVPPITRTATGIRDFQDQDI
                     EALEFIKCFRSAGVSVDSLVDYMSLYQKGDETREERLGILEEEKQKLEERLSQLQTAL
                     NRLNLKIKLYKEGKF"
     gene            complement(21835..22725)
                     /locus_tag="VXE25_000199"
     CDS             complement(21835..22725)
                     /locus_tag="VXE25_000199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000645104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation transporter"
                     /protein_id="HEV0770733.1"
                     /translation="MKAKYAVWVAFFLNLTYAIVEFIAGGVFGSSAVLADSVHDLGDA
                     IAIGISAFLETISNREEDNQYTLGYKRFSLLGALVTAVILVTGSVLVILENVTKILHP
                     QPVNDEGILWLGIIAITINLLASLVVGKGKTKNESILSLHFLEDTLGWVAVILMAIVL
                     RFTDWYILDPLLSLVISFFILSKALPRFWSTLKIFLDAVPEGLDIKQVKSGLERLDNV
                     ASLNQLNLWTMDALEKNAIVHVCLKEMEHMETCKESIRIFLKDCGFQNITIEIDADLE
                     THQTHKRKVCDLERSYEHQH"
     gene            22858..23394
                     /locus_tag="VXE25_000200"
     CDS             22858..23394
                     /locus_tag="VXE25_000200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HEV0770734.1"
                     /translation="MTNIDRRISKTKKAIYQAFIQLLNAKGYEATTVQDIIDLADVGR
                     STFYCHYESKELLLDQLCRYLFHHLFEREQAISTEDYLAHLFLHFHKNQDHITSLLFS
                     KNDYFLRQLHKELEHHVYSVLADNLKEAHPNMPTSYLQHLVVSNFIETLTWWLKKGQD
                     FTGQEVVQFYLDLLIPKN"
     gene            complement(23560..24366)
                     /locus_tag="VXE25_000201"
     CDS             complement(23560..24366)
                     /locus_tag="VXE25_000201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinamide riboside transporter PnuC"
                     /protein_id="HEV0770735.1"
                     /translation="MHTYLQKKIENIKTTLGEMSGGYRRMVAAMADLGFSGTMKAIWD
                     DLFAHRSFAQWIYLLVLGSFPLWLELVYEHRIVDWIGMICSLTGIICVIFVSEGRASN
                     YLFGLINSVIYLILALQKGFYGEVLTTLYFTVMQPIGLLVWIYQAQFKKEKQEFVARK
                     LDGKGWTKYLSISVLWWLAFGFIYQSIGANRPYRDSITDATNGVGQILMTAVYREQWI
                     FWAATNVFSIYLWWGESLQIQGKYLIYLINSLVGWYQWSKAAKQNTDLLN"
     gene            complement(24711..26231)
                     /locus_tag="VXE25_000202"
     CDS             complement(24711..26231)
                     /locus_tag="VXE25_000202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease/substrate-binding
                     protein"
                     /protein_id="HEV0770736.1"
                     /translation="MTNLIATFQDRFSDWLTALSQHLQLSLLTLLLAILLAIPLAVFL
                     RYHEKLADWVLQIAGIFQTIPSLALLGLFIPLMGIGTLPALTALVIYAIFPILQNTIT
                     GLKGIDPSLQEAGIAFGMTRWERLKKFEIPLAMPVIMSGIRTAAVLIIGTATLATLIG
                     AGGLGSFILLGIDRNNASLILIGALSSAVLAIAFNFLLKVMEKAKLRTIFSGFALVAL
                     LLGLSYSPALLAQKEKENLIIAGKIGPEPEILANMYKLLIEENTSMTATVKPNFGTTS
                     FLYEALKKGDIDIYPEFTGTVTESLLQPSPKVSHEPEQVYQVARDGIAKQDHLAYLKP
                     MSYQNTYAVAVPKKIAQEYGLKTISDLKKVEGQLKAGFTLEFNDREDGNKGLQSMYGL
                     NLNVATMQPALRYQAIQSGDIQITDAYSTDAELERYDLQVLEDDKQLFPPYQGAPLMK
                     EALLKKHPELERVLNTLAGKITESQMSQLNYQVGVEGKSAKQVAKEFLQEQGLLKK"
     gene            complement(26224..26952)
                     /locus_tag="VXE25_000203"
     CDS             complement(26224..26952)
                     /locus_tag="VXE25_000203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0770737.1"
                     /translation="MIEYKNVALRYTEKDVLRDVNLQIEDGEFMVLVGPSGSGKTTML
                     KMINRLLEPTDGNIYMDGKRIKDYDERELRLSTGYVLQAIALFPNLTVAENIALIPEM
                     KGWSKEEITKKTEELLAKVGLPVAEYGHRLPSELSGGEQQRVGIVRAMIGQPKIFLMD
                     EPFSALDAISRKQLQVLTKELHKEFGMTTIFVTHDTDEALKLADRIAVLQDGEIRQVA
                     NPETILKVPATDFVADLFGGSVHD"
     gene            complement(26967..27731)
                     /locus_tag="VXE25_000204"
     CDS             complement(26967..27731)
                     /locus_tag="VXE25_000204"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000043863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="HEV0770738.1"
                     /translation="MSQQVKNAHNLYIHAIQDGRVAEAQAQSVGDTYIQHSTGVPDGK
                     EGFAAFFADFFERHPERQIKIVRTIEDGNLVFVHVHQYLNGGEAQWVTTDTFRADENG
                     RIVEHWDVIDYYRTPENDQLDQIFGDFEIKDLDKKAENKKLVRRFLTETFQNGELEQW
                     SDYVADDLIQHNHEIGQGSAAYKNYVAEYSVTFDFVFQLLGQGNYVVSYGQTQIDGVA
                     YAQYDIFRLENGKIVEHWDNKEVMPKVEDLTNRGKF"
     gene            complement(27735..28178)
                     /locus_tag="VXE25_000205"
     CDS             complement(27735..28178)
                     /locus_tag="VXE25_000205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000655204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HEV0770739.1"
                     /translation="MKDSHLLAHHIRLLNGRIFQKLLSQDPEALYRGEQGKILAVLWN
                     SETGCATATDIALATGLANNTLTTMIKKLEEQKLVIVSPCGKDKRKKYLVLTELGKFQ
                     KEVGHRVSQKLDTIFYKGFSEEEIHQFEGFQERILANLKEKENEV"
     gene            complement(28860..29156)
                     /locus_tag="VXE25_000206"
     CDS             complement(28860..29156)
                     /locus_tag="VXE25_000206"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000230158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin immunity protein"
                     /protein_id="HEV0770740.1"
                     /translation="MVEPNLESLIKDLYNHARHDLSEDLVAALLETTKKLPTTNEQLQ
                     AVRLSSLVNRELLLNPKHPAPELLNLARFVKREEAKYRGTATSALMYEELFKML"
     gene            complement(29178..30242)
                     /gene="pepA"
                     /locus_tag="VXE25_000207"
     CDS             complement(29178..30242)
                     /gene="pepA"
                     /locus_tag="VXE25_000207"
                     /EC_number="3.4.11.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamyl aminopeptidase"
                     /protein_id="HEV0770741.1"
                     /translation="MTTLFSKIKEVTELAAVSGHEAPVRAYLREKLTPHVDEVVTDGL
                     GGIFGIKHSEAVDAPRVLVASHMDEVGFMVSEIKPDGTFRVVEIGGWNPMVVSSQRFK
                     LLTRDGHEIPVISGSVPPHLTRGKGGPTMPAIADIVFDGGFADKAEAESFGIRPGDTI
                     VPDSSAILTANEKNIISKAWDNRYGVLMVSELAEALSGQKLGNELYLGSNVQEEVGLR
                     GAHTSTTKFDPEVFLAVDCSPAGDVYGGQGKIGDGTLIRFYDPGHLLLPGMKDFLLTT
                     AEEAGIKYQYYCGKGGTDAGAAHLKNGGVPSTTIGVCARYIHSHQTLYAMDDFLEAQA
                     FLQALVKKLDRSTVDLIKHY"
     gene            30643..31344
                     /gene="galE"
                     /locus_tag="VXE25_000208"
     CDS             30643..31344
                     /gene="galE"
                     /locus_tag="VXE25_000208"
                     /EC_number="5.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000167854.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="HEV0770742.1"
                     /translation="MTKTILVTGGTSYIGSHTVKALLNAGYKVHVLDNLSTGNRAAVD
                     SRASFKELDIYDASALKAYLEENQIDAVLHCAGEIVVSESIENPSKYFTANVAGMNQV
                     LKVLSEVGIQKIMFSSTASLYGNNCIDKPVTEDTLLDPVNPYAETKLMGERMIYWMAN
                     RYDWKYVIFRYFNVAGAEMDASNGLRVKNPTHIIPNINKTALGQNDSLKIFGDDYDTR
                     DGSCIRDYIYVLDLA"
     gene            31767..32726
                     /locus_tag="VXE25_000209"
     CDS             31767..32726
                     /locus_tag="VXE25_000209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000777236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEV0770743.1"
                     /translation="MKLSHYLIGLLLLLVFLSISIGTSDFSWGKLFDFDQQTWLLFQE
                     SRLPRTISILLTASSMSMAGLLMQTITQNQFAAPSTVGTTEAAKLGMVLSLFVFPSAS
                     LTQKMLFAFVSSILFTLFFLAFMTIFTVKERWMLPLIGIIYSGIIGSVTEVIAYRFNL
                     VQSMTAWTQGSFSMIQTHQYEWLFLGLIILITVWKLSQTFTIMNLGKETSESLGISYS
                     LLEKLALFLVALTTSVTMITVGGLPFLGVIVPNLVRKRYGDNLSQTKLMVALVGANLV
                     LACDILSRVLIRPYELSVSLLLGIIGSLVFILLLWRGGRKDAN"
     gene            32716..33672
                     /locus_tag="VXE25_000210"
     CDS             32716..33672
                     /locus_tag="VXE25_000210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001193667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron chelate uptake ABC transporter family
                     permease subunit"
                     /protein_id="HEV0770744.1"
                     /translation="MQTKSKHTKLFWILIILAIGACLLYFWPITHLSAFAWKLRSQKI
                     IVYLLVAIATGISTISFQTLTENRFLTPSILGIESFYVLLQTLLLVFESKFLQLGKSP
                     ILEFLVLLLVQSLFFLALQGYLKTLMKQDLVFILLICLALRSLFRNISTFLQVLMDPN
                     EYDKLQNSLFASFQHLNTSILAIGSLIILALTIFFFRKAVVLDVLHLQRETAQILGLD
                     VEKEQKELLWGIVLLTSTATALVGPMAFFGFMLANLTYLIVKDYQHKLLFIVAILVGF
                     ISLTLGQALIERVFALEIRISMIIESVGGFLFFILLYRRARQ"
     gene            33669..34421
                     /locus_tag="VXE25_000211"
     CDS             33669..34421
                     /locus_tag="VXE25_000211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000764290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEV0770745.1"
                     /translation="MKLENIDKSIQKQDILQGISLEVSPQKLTAFIGPNGAGKSTLLS
                     IMSRLTKKDQGVLSIKGREIESWNSQELAQELTILKQKINYQAKLTVEELVSFGRFPY
                     SRGRLRSEDWEKIRETLNYLELTNLKDRYINSLSGGQLQRVFIAMVLAQDTDFILLDE
                     PLNNLDIKQSVSMMQILRRLVEELGKTIIIVLHDINMASQYADEIVAFKDGQVFSKGR
                     TDQIMQADLLSQLYEIPITLADINDKKICIYS"
     gene            34517..35482
                     /locus_tag="VXE25_000212"
     CDS             34517..35482
                     /locus_tag="VXE25_000212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000858258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="siderophore ABC transporter substrate-binding
                     protein"
                     /protein_id="HEV0770746.1"
                     /translation="MKTSLKLYFTALVASFLLLLGACSTNSSTSQTETSSSAPTEVTI
                     KSSLDEVKLSKVPEKIVTFDLGAADTIRALGFEKNIVGMPTKTVPTYLKDLVGTVKNV
                     GSMKEPDLEAIAALEPDLIIASPRTQKFVDKFKEIAPTVLFQASKDDYWTSTKANIES
                     LASAFGETGTQKAKEELAKLDKSIQKVATKNESSDKKALAILLNEGKMAAFGAKSRFS
                     FLYQTLKFKPTDTTFEDSRHGQEVSFESVKEINPDILFVINRTLAIGGDNSSNDGVLE
                     NALIAETPAAKNGKIIQLTPDLWYLSGGGLESTKLMIEDIQKALK"
     gene            complement(35707..35949)
                     /gene="yidD"
                     /locus_tag="VXE25_000213"
     CDS             complement(35707..35949)
                     /gene="yidD"
                     /locus_tag="VXE25_000213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertion efficiency factor
                     YidD"
                     /protein_id="HEV0770747.1"
                     /translation="MKRILIAPVRFYQRFISPVFPPSCRFELTCSNYMIQAIEKHGFK
                     GVLMGLARILRCHPWSKTGKDPVPDHFSLKRNQEGE"
     gene            complement(35949..36671)
                     /locus_tag="VXE25_000214"
     CDS             complement(35949..36671)
                     /locus_tag="VXE25_000214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006150169.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA pseudouridine synthase"
                     /protein_id="HEV0770748.1"
                     /translation="MRINKYIAHAGVASRRKAEELIKQGLVTVNGQVVRELATTIKSG
                     DKVEVEGQPIYNEEKVYYLLNKPRGVISSVTDDKGRKTVVDLLPNVKERIYPVGRLDW
                     DTSGVLILTNDGDFTDEMIHPRNEIDKVYVARVKGVANKDNLRPLTRGLEIDGKKTKP
                     AVYEILKVDPVKNRSVVQLTIHEGRNHQVKKMFEAVGLQVDKLSRTRFGHLDLTGLRP
                     GESRRLNKKEISQLHTMAVTKK"
     gene            complement(36658..37227)
                     /locus_tag="VXE25_000215"
     CDS             complement(36658..37227)
                     /locus_tag="VXE25_000215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000105309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="segregation/condensation protein B"
                     /protein_id="HEV0770749.1"
                     /translation="MSTLAKIEALLFVAGEDGIRVRQLAELLSLPPTGIQQSLGKLAQ
                     KYEKDPDSSLALIETSGAYRLVTKPQFAEILKEYSKAPINQSLSRAALETLSIIAYKQ
                     PITRIEIDAIRGVNSSGALAKLQAFDLIKEDGKKEVLGRPNLYVTTDYFLDYMGINHL
                     EELPVIDELEIQAQESQLFGERIEEDENQ"
     gene            complement(37246..37974)
                     /locus_tag="VXE25_000216"
     CDS             complement(37246..37974)
                     /locus_tag="VXE25_000216"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000351912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="segregation/condensation protein A"
                     /protein_id="HEV0770750.1"
                     /translation="MDIKLKDFEGPLDLLLHLVSKYQMDIYDVPITEVIEQYLAYVST
                     LQAMRLEVTGEYMVMASQLMLIKSRKLLPKVAEVTDLGDDLEQDLLSQIEEYRKFKLL
                     GEHLEAKHQERAQYYSKAPTELIYEDAELVHDKTTIDLFLAFSNILAKKKEEFAQNHT
                     TILRDEYKIEDMMIIVKESLIGRDQLRLQDLFKEAQNVQEVITLFLATLELIKTQELI
                     LVQEESFGDIYLMEKKEESQVPQS"
     gene            complement(37974..38714)
                     /gene="xerD"
                     /locus_tag="VXE25_000217"
     CDS             complement(37974..38714)
                     /gene="xerD"
                     /locus_tag="VXE25_000217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004245562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific tyrosine recombinase XerD"
                     /protein_id="HEV0770751.1"
                     /translation="MPMRDRISAFLEEKQGLSVNSKQSYKYDLEQFLDMVGERISETS
                     LKIYQAQLANLKISAQKRKISACNQFLYFLYQKGEVDSFYRLELAKQAEKKTEKPEIL
                     YLDSFWQESDHPEGRLLALLILEMGLLPSEILAIKVADINLDFQVLRISKASQQRIVT
                     IPTALLSELEPLMGQTYLFERGEKPYSRQWAFRQLESFVKEKGFPSLSAQVLREQFIL
                     RQIENKVDLYEIAKKLGLKTVLTLEKYR"
     gene            complement(38705..39166)
                     /locus_tag="VXE25_000218"
     CDS             complement(38705..39166)
                     /locus_tag="VXE25_000218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000560721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBS domain-containing protein"
                     /protein_id="HEV0770752.1"
                     /translation="MIAKEFETFLLGQEETFLTPAKNLAVLIDTHNADHATLLLSQMT
                     YTRVPVVTDEKQFVGTIGLRDIMAYQMEHDLSQEIMADTDIVHMTKTDVAVVSPDFTI
                     TEVLHKLVDESFLPVVDAEGIFQGIITRKSILKAVNALLHDFSKEYEIRCQ"
     gene            complement(39163..39684)
                     /locus_tag="VXE25_000219"
     CDS             complement(39163..39684)
                     /locus_tag="VXE25_000219"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001118598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HEV0770753.1"
                     /translation="MAKQTIIVMSDSHGDSLIVEEVRDRYVGKVDAVFHNGDSELRPD
                     SPLWEGIRVVKGNMDFYAGYPERLVTELGSTKIIQTHGHLFDINFNFQKLDYWAQEEE
                     AAICLYGHLHVPSAWLEGKILFLNPGSISQPRGTIRECLYARVEIDDSYFKVDFLTRD
                     HEVYPGLSKEFSR"
     gene            complement(39660..40631)
                     /locus_tag="VXE25_000220"
     CDS             complement(39660..40631)
                     /locus_tag="VXE25_000220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000182414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside-triphosphate diphosphatase"
                     /protein_id="HEV0770754.1"
                     /translation="MTNKIYEYKDDQDWYVGSYSIFGGVNSLSDYKTDFPLFEFSKIF
                     GDEEYGFPLSVTVLRYGSTYRLFSFVVDMLNQEMGRNLEVIQRHGALLLVENGQLLYV
                     ELPKEGVNVHDFFETSKVRETLLIATRNEGKTKEFRAIFDKLGYDVENLNDYPDLPEV
                     AETGMTFEENARLKAETISQLTGKMVLADDSGLKVDVLGGLPGVWSARFAGVGATDRE
                     NNAKLLHELAMVFELKDRSAQFHTTLVVASPNKESLVVEADWSGYINFEPKGENGFGY
                     DPLFLVGETGESSAELTLEEKNSQSHRALAVKKLLEVFPSWQSKPSL"
     gene            complement(40628..41422)
                     /gene="racE"
                     /locus_tag="VXE25_000221"
     CDS             complement(40628..41422)
                     /gene="racE"
                     /locus_tag="VXE25_000221"
                     /EC_number="5.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000370386.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate racemase"
                     /protein_id="HEV0770755.1"
                     /translation="MDNRPIGFLDSGVGGLTVVRELMRQLPHEEIVYIGDSARAPYGP
                     RPAEQIREYTWQLVNFLLTKDVKMIVIACNTATAVVWEEIKAQLDIPVLGVILPGASA
                     AIKSSQGGKIGVIGTPMTVQSDIYRQKIHDLDPDLQVESLACPKFAPLVESGALSTSV
                     TKKVVYETLRPLVGKVDSLILGCTHYPLLRPIIQNVMGPKVQLIDSGAECVRDISVLL
                     NYFEINRGRDAGPLHHRFYTTASSQSFAQIGEEWLEKEIHVEHVEL"
     gene            complement(41629..41877)
                     /locus_tag="VXE25_000222"
     CDS             complement(41629..41877)
                     /locus_tag="VXE25_000222"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000364981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YneF family protein"
                     /protein_id="HEV0770756.1"
                     /translation="MDLLLAIVLIVLAFLGGALGGMYLVRKQIEKEFADNPRLNAEAV
                     RTLLSANGQKPSEAKVQQVYHQIIRQQKAALANNKKKK"
     gene            complement(42019..43644)
                     /gene="treC"
                     /locus_tag="VXE25_000223"
     CDS             complement(42019..43644)
                     /gene="treC"
                     /locus_tag="VXE25_000223"
                     /EC_number="3.2.1.93"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000171230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha,alpha-phosphotrehalase"
                     /protein_id="HEV0770757.1"
                     /translation="MTLDKGKVVYQIYPKSYKDTTENGIGDFRGIIEKIPYLAKLGVD
                     MVWLNPFYPSPQRDNGYDISDYMAVDPLFGDMADFEEMVCVGKEHKIDFMLDMVLNHC
                     STEHEWFQKALAGDKYYQDFFFIQDQPTDWQSKFGGSAWAPFGDTGKYYLHLFDETQA
                     DLNWRNSNVRKELFKVVNFWRDKGVKGFRFDVINLIGKDEVSVDCPENEGKPAYTDKP
                     IVHNYLRMMNQATFGSDDSFMTVGEMSSTTMENCVLYSSPDRQELSMTFNFHHLKVDY
                     KDGQKWTLAPFDFEELKSLYHSWGKEMSDKDGWSALFWNNHDQPRALNRFVDIQNFRK
                     EGATMLAASIHLSRGTPYIYMGEEIGMIDPDYDSMADYVDVESLNAYQMLLEEGKSQQ
                     EAFQIIQAKSRDNSRIPMQWDASENAGFSTGTPWLKAGKSYKDINVENEIQGPIFTFY
                     QDLIRLRKEMPIISEGSYKPAFEDSKQVYAFERQFEDQKLLVLNNFYAKEVEIDLPAV
                     YQNGQILISNYEDAEVSEKILLKPYQTLAIYVN"
     gene            complement(43822..45789)
                     /gene="treP"
                     /locus_tag="VXE25_000224"
     CDS             complement(43822..45789)
                     /gene="treP"
                     /locus_tag="VXE25_000224"
                     /EC_number="2.7.1.201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system trehalose-specific EIIBC component"
                     /protein_id="HEV0770758.1"
                     /translation="MGKFEQEAKDLLQAIGGKENVTAVTHCATRMRFVLGDDKKANVK
                     AIESIPAVKGTFTNAGQFQVIIGNDVPIFYNDFTAVSGIEGVSKEAAKSAAKSNQNVV
                     QCVMTTLAEIFTPIIPALIVGGLILGFRNVLEGVHWSMLDGKTITESSQFWAGVNHFL
                     WLPGEAIFQFLPVGITWSVSRKMGTSQILGIVLGICLVSPQLLNAYAVASTPAADIAA
                     NWVWNFGYFTVNRIGYQAQVIPALLAGLSLSYLEIFWRKHIPEVISMIFVPFLSLIPA
                     LILAHTVLGPIGWTIGQGLSSVVLAGLTGPVKWLFGAIFGALYAPFVITGLHHMTNAI
                     DTQLIADAGGTALWPMIALSNIAQGSAVFAYYFMHRHDEREAQVSLPATISAYLGVTE
                     PALFGVNVKYIYPFVAGMTGSALAGMLSVTFNVTAASIGIGGLPGILSIQPQYMLPFA
                     GTMLVAIVVPMLLTFFFRKAGLFTKTEGDTNLQAEFVAQEEAEFVNHEPVELTSVEII
                     SPLTGQVKELSQATDPIFASGVMGQGLVIEPSQGELTSPVNGTVTVLFPTKHAIGIVS
                     DEGVELLIHIGMDTVGLDGKGFESLVVQGDHVTVGQQLIRFDMDVIKAAGLVTETPVI
                     ITNQDAYTATIPGTYPTTIQAGASLMVATRI"
     gene            45974..46684
                     /gene="treR"
                     /locus_tag="VXE25_000225"
     CDS             45974..46684
                     /gene="treR"
                     /locus_tag="VXE25_000225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trehalose operon repressor"
                     /protein_id="HEV0770759.1"
                     /translation="MKKYQQLFKQIQETIQNETYAVGDFLPSEHDLMEQYQVSRDTVR
                     KALSLLQEEGLIKKIRGQGSQVVKEETVNFPVSNLTSYQELVKELGLRSKTNVVSLDK
                     IIIDKKSSLITGFPEFRMVWKVVRQRVVDDLVSVLDTDYLDMELIPNLTRQIAEQSIY
                     SYIENGLKLLIDYAQKEITIDHSSDRDKILMDIGKDPYVVSIKSKVYLQDGRQFQFTE
                     SRHKLEKFRFVDFAKRKK"
     gene            complement(46717..47520)
                     /locus_tag="VXE25_000226"
     CDS             complement(46717..47520)
                     /locus_tag="VXE25_000226"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000157668.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEV0770760.1"
                     /translation="MASLLTLENIHKTFEAGTVNENHVLKGLDLEVEEGDFISVIGRN
                     GAGKSTLMNILAGNLSVDEGDLLLAGKSIKHLSVRKRAKDIARVFQDPKMGTASRLTI
                     EENMAIALRRGQKRGLGWGVKEKDRIQFQEALKELNIGLENRLKVDTQYLSGGQRQAL
                     TLVMAALVKLKLLLLDEHTAALDPKTSQMVMDLTQKIVEYHQWTTLMITHDMNHAIEY
                     GNRLIMLYQGKIVVDVKGEEKKHLTVEDLMHLFQKNSGQSLVSDELVLG"
     gene            complement(47533..48410)
                     /locus_tag="VXE25_000227"
                     /pseudo
     CDS             complement(47533..48410)
                     /locus_tag="VXE25_000227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001012086.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
     gene            complement(48422..49282)
                     /locus_tag="VXE25_000228"
                     /pseudo
     CDS             complement(48422..49282)
                     /locus_tag="VXE25_000228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813348.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
     gene            complement(49850..50776)
                     /locus_tag="VXE25_000229"
     CDS             complement(49850..50776)
                     /locus_tag="VXE25_000229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001291287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0770761.1"
                     /translation="MSEKLVEIKDLEISFGEGSKKFVAVKNANFFINKGETFSLVGES
                     GSGKTTIGRAIIGLNDTSNGDIIFDGQKINGKKSREQAAELIRRIQMIFQDPAASLNE
                     RATVDYIISEGLYNHRLFKDEEERKEKVQNIIREVGLLAEHLTRYPHEFSGGQRQRIG
                     IARALVMQPDFVIADEPISALDVSVRAQVLNLLKKFQKELGLTYLFIAHDLSVVRFIS
                     DRIAVIYKGVIVEVAETEELFNNPIHPYTQALLSAVPIPDPILERKKVLKVYDPSQHD
                     YETDKPSMVEIRPGHYVWANQTELARYQKGLN"
     gene            complement(50787..51854)
                     /locus_tag="VXE25_000230"
     CDS             complement(50787..51854)
                     /locus_tag="VXE25_000230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0770762.1"
                     /translation="MTKEKNVILTARDIVVEFDVRDKVLTAIRGVSLELVEGEVLALV
                     GESGSGKSVLTKTFTGMLEENGRIAQGSIDYRGQDLTALSSHKDWEQIRGAKIATIFQ
                     DPMTSLDPIKTIGSQITEVIVKHQGKTAKEAKELAIDYMNKVGIPDADRRFNEYPFQY
                     SGGMRQRIVIAIALACRPDVLICDEPTTALDVTIQAQIIDLLKSLQNEYHFTTIFITH
                     DLGVVASIADKVAVMYAGEIVEYGTVEEVFYDPRHPYTWSLLSSLPQLADDKGDLYSI
                     PGTPPSLYTDLKGDAFALRSDYAMQIDFEQKAPQFSVSETHWAKTWLLHEDAPKVEKP
                     AVIANLHDKIREKMGFAHLAD"
     gene            complement(51863..52789)
                     /locus_tag="VXE25_000231"
     CDS             complement(51863..52789)
                     /locus_tag="VXE25_000231"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEV0770763.1"
                     /translation="MSTIDKEKFQFVKRDDFASETIDAPAYSYWKSVFKQFMKKKSTV
                     VMLGILVAIILISFIYPMFSKFDFNDVSKVNDFSVRYIKPNAEHWFGTDSNGKSLFDG
                     VWFGARNSILISVIATVINLVIGVFVGGIWGISKSVDRVMMEVYNVISNIPPLLIVIV
                     LTYSIGAGFWNLIFAMSVTTWIGIAFMIRVQILRYRDLEYNLASRTLGTPTLKIVAKN
                     IMPQLVSVIVTTMTQMLPSFISYEAFLSFFGLGLPITVPSLGRLISDYSQNVTTNAYL
                     FWIPLTTLVLVSLSLFVVGQNLADASDPRTHR"
     gene            complement(52789..54285)
                     /locus_tag="VXE25_000232"
     CDS             complement(52789..54285)
                     /locus_tag="VXE25_000232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000759888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEV0770764.1"
                     /translation="MKKYIFMRVLRSLVSIFLVTTLTYTIIYTLVPRKLIFKQDPNYN
                     KIATTADKRDNYENTVFERMGYIEYYDTKELQEKASSMDSSVTVEANATNKAIYEKYI
                     NQLGHGWTLGEFTESGQFYATREIPIFERVFHFYANLIDIDHTNKIQDPENPDLKRYL
                     RFENDPAIGWSLVGSGTKHKYLLYFNSQFPFVHQNFVNLNLGDSYPTYANTPVLQVIT
                     QGQGQTKTAQVQFPTGKKTSSVNIYSRTYKSPSQADSREVASYGKDDPYTATESNYQY
                     PSMIVSSAITGLIGLVLAYALAVPLGSAMARFKNTWIDSLSTGTLTFLLALPTIALVY
                     IVRLIGSSIALPDSFPILGAGDWRSYVLPAVILGLLGAPVTAIWIRRYMIDLQSQDFV
                     RFARAKGLSEKEISNKHIFKNAMVPLVSGIPGAIIGVIGGATLTETVFAFPGMGKMLI
                     DSVKASNNSMVVGLVFIFTCISIFSRLLGDIWMTIIDPRIKLTEKGGK"
     gene            complement(54352..56331)
                     /locus_tag="VXE25_000233"
     CDS             complement(54352..56331)
                     /locus_tag="VXE25_000233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000742236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HEV0770765.1"
                     /translation="MKKNRVFATAGLVLLAAGVLAACSSSKSSDSSAPKAYGYVYTAD
                     PETLDYLISSKNSTTVVTSNGIDGLFTNDNYGNLAPAVAEDWEVSKDGLTYTYKIRKG
                     VKWFTSDGEEYAEVTAKDFVNGLKHAADKKSEAMYLAENSVKGLADYLSGTSTDFSTV
                     GVKAVDDYTLQYTLNQPEPFWNSKLTYSIFWPLNEEFETSKGSDFAKPTDPTSLLYNG
                     PFLLKGLTAKSSVEFVKNEQYWDKENVHLDTINLAYYDGSDQESLERNFTSGAYSYAR
                     LYPTSSNYSKVAEEYKDNIYYTQSGSGIAGLGVNIDRQSYNYTSKTTDSEKVATKKAL
                     LNKDFRQALNFALDRSAYSAQINGKDGAALAVRNLFVKPDFVSAGEKTFGDLVAAQLP
                     AYGDEWKGVNLADGQDGLFNADKAKAEFAKAKKALEADGVQFPIHLDVPVDQASKNYI
                     SRIQSFKQSVETVLGVENVVVDIQQMTSDEFLNITYYAANASSEDWDVSGGVSWGPDY
                     QDPSTYLDILKTTSSETTKTYLGFDNPNSPSVVQVGLKEYDKLVDEAAKETSDLNVRY
                     EKYAAAQAWLTDSSLFIPAMASSGAAPVLSRIVPFTGASAQTGSKGSDVYFKYLKLQD
                     KVVTKEEYEKAREKWLKEKAESNEKAQKELASHVK"
     gene            complement(57017..58210)
                     /locus_tag="VXE25_000234"
     CDS             complement(57017..58210)
                     /locus_tag="VXE25_000234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008293041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen ligase family protein"
                     /protein_id="HEV0770766.1"
                     /translation="MKSIGFIEKLKGLSSKELILLGIILSIFLPFYLFVVVLCLYIIS
                     LIFTGDMKSILQKMGEHPMLLLFLSYSTVISILAQNWMGLVASVGMFLFTIFFLHYQS
                     ILSHKFFRLILQFVLFGSVLSAAFASLEHFQIVKKFNYAFLSPNMQVWHQNRAEVTFF
                     NPNYYGIICCFCIMIAFYLFTTTKLNWLKVFCVIAGFVNLFGLNFTQNRTAFPAIIAG
                     AIIYLFTTIKNWKAFWLSIGVFAIGLSFLFSSDLGVRMGTLDSSMEERISIWDAGMAL
                     FKQNPFWGEGPLTYMHSYPRIHAPYHEHAHSLYIDTILSYGIVGTILLVLSSVAPVRL
                     MMDMSQESGKRPIIGLYLSFLTVVAVHGIFDLALFWIQSGFIFLLVMCSIPLEHRMLV
                     SDMTD"
     gene            complement(58348..59790)
                     /gene="gtfA"
                     /locus_tag="VXE25_000235"
     CDS             complement(58348..59790)
                     /gene="gtfA"
                     /locus_tag="VXE25_000235"
                     /EC_number="2.4.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001122330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sucrose phosphorylase"
                     /protein_id="HEV0770767.1"
                     /translation="MPIQNKTMLITYSDSLGNNLKDLYDNLEEHFRDAIGGVHLLPFF
                     PSTGDRGFAPVDYDEVDSAFGDWEDVKRLGERYYLMFDFMINHISRQSKYYKDYQEKH
                     EASEFKALFLNWDKFWPENRPTQSDVDLIYKRKDRAPKQEIVFEDGSVEHLWNTFGEE
                     QIDLDVTKEVTMEFIRKTIQHLASNGCDLIRLDAFAYAVKKLDTNDFFVEPDIWDLLD
                     KVRDIAAEYGTELLPEIHEHYSIQFKIADHDYYVYDFALPMVTLYTLYSSRTERLAKW
                     LKMSPMKQFTTLDTHDGIGVVDVKDILTDEEIDYASNELYKVGANVKRKYSSAEYNNL
                     DIYQINSTYYSALGDDDVKYFLARLIQAFAPGIPQVYYVGLLAGKNDLKLLEETKEGR
                     NINRHYYSNEEIAKEVQRPVVKALLNLFSFRNRSEAFDLEGTTEIETPTAHSIVIKRQ
                     NKDKSVTAVVEIDLQNQTYRVIENGVEVSF"
     gene            complement(60067..60147)
                     /locus_tag="VXE25_000236"
                     /pseudo
     CDS             complement(60067..60147)
                     /locus_tag="VXE25_000236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            complement(60148..60981)
                     /locus_tag="VXE25_000237"
     CDS             complement(60148..60981)
                     /locus_tag="VXE25_000237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000711263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HEV0770768.1"
                     /translation="MKQDERKALIGKYILLILGTVLILVPLLATLFSSFKPTKDIVDN
                     FFGFPTNFTWDNFSRLLADGIGGYYWNSVVITVLSLLAVMIFIPMAAYSIARNMSKRK
                     AFTIMYTLLILGIFVPFQVIMIPITVMMSKLGLANTFGLILLYLTYAIPQTLFLYVGY
                     IKISIPESLDEAAEIDGANQFTTYFRIIFPMMKPMHATTMIINALWFWNDFMLPLLVL
                     NRDSKMWTLPLFQYNYAGQYFNDYGPSFASYVVGIISITIVYLFFQRHIISGMSNGAV
                     K"
     gene            complement(60995..61861)
                     /locus_tag="VXE25_000238"
     CDS             complement(60995..61861)
                     /locus_tag="VXE25_000238"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000757171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEV0770769.1"
                     /translation="MKKVLQKYWAWAFVVIPLLLQAIFFYVPMFQGAFYSFTNWTGLT
                     YNYKFVGLNNFKLLFMDPKFMNAIGFTAIITIAMVVGEIALGIFIARVLNSKIKGQTF
                     FRAWFFFPAVLSGLTVALIFKQVFNYGLPAIGNALHIEFLQTSLLGTKWGAIFAAVFV
                     LLWQGVAMPIIIFLAGLQSIPTEITEAARIDGATSKQVFWNIELPYLLPSVSIVFILA
                     LKGGLTAFDQVFAMTGGGPNNATTSLGLLVYNYAFKNNQFGYANAIAVILFFLIVVIS
                     IIQLRVSKKFEI"
     gene            complement(61875..63134)
                     /locus_tag="VXE25_000239"
     CDS             complement(61875..63134)
                     /locus_tag="VXE25_000239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HEV0770770.1"
                     /translation="MEWYKKIGLLATTGLALFGLGACSNYGKSADDTVTIEYFNQKKE
                     MTKTLEEITRDFEKENPKIKVKVVNVPNAGEVLKTRVLAGDVPDVVNIYPQSIELQEW
                     AKAGVFEDLSNKDYLKRVKNGYAEKYAVNEKVYNVPFTANAYGIYYNKDKFEELGLKV
                     PETWDEFEQLVKDIVAKGQTPFGIAGADAWTLNGYNQLAFATATGGGKEANQYLRYSQ
                     PNAIKLSDPIMKDDIKVMDILRINGSKQKNWEGAGYTDVIGAFARGDVLMTPNGSWAI
                     TAINEQKPNFKIGTFMIPGKEKGQSLTVGAGDLAWSISATTKHPKEANAFVEYMTRPE
                     VMQKYYDVDGSPTAIEGVKQAGEDSPLAGMTEYAFTDRHLVWLQQYWTSEADFHTLTM
                     NYVLTGDKQGMVNDLNAFFNPMKADVD"
     gene            complement(63226..65388)
                     /locus_tag="VXE25_000240"
     CDS             complement(63226..65388)
                     /locus_tag="VXE25_000240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000538915.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-galactosidase"
                     /protein_id="HEV0770771.1"
                     /translation="MGVRIENNLFYVESKNLSLIIENQNGYLLLKHLGKTIKNYKGSN
                     SVYERDHAFSGNPTATNRTFSLDTQRQIFGQHGLGDFRKPTIQVQHSVTEVTDFRFVE
                     AKILKGQNGPQGLPSPHSMDDTETLVLMLEDSKAQLSLTLYYTTFNNDATIASYSKLD
                     NNSNQEVVIHKDFSFMADFPAADYEIVTLQGAYAREKTVRRQQVEQGIFSISSNRGAS
                     GHTQTPALLLCEQGVTEDAGNVFAIQLMYSGNFEAFVQKNQLNEVRVAIGINPENFSW
                     KLAPEEYFETPVALVTHSDQGLTGISHESQNFVLKHIMLSEFSKKERPILINNWEATY
                     FDFQREKLLELADEAKKVGIELFVLDDGWFGNRFDDNRALGDWVVNEEKLGGSLESLI
                     SAIHERGLQFGLWLEPEMISVDSDLYRRHPDWAIQVPDYEHTYSRNQLVLNLANPQVV
                     EYLKSVLDQLLSYHDIDYIKWDMNRNITKLGNGLTYLETQMQSHQYMLGLYELVSYLT
                     EKHSHILFESCSGGGGRNDLGMMRYFPQVWASDNTDAIARLPIQYGSSYLYPTISMGA
                     HVSAVPNHQMGRMTPLETRGLVAMMGNLGYELDLTNLSDEEKATIANQVNLYKELRPV
                     VQLGQQYRLINPDTASNEAAVQFNYGNQTIVTYVRVLSVVETMETTLKLKDLDEEGLY
                     KLQENGEVYSGAELMYAGLTVILSQGDFLSRQYIFRKL"
     gene            65496..66375
                     /locus_tag="VXE25_000241"
                     /pseudo
     CDS             65496..66375
                     /locus_tag="VXE25_000241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000959966.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
     gene            66372..67307
                     /locus_tag="VXE25_000242"
     CDS             66372..67307
                     /locus_tag="VXE25_000242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000844514.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional biotin--[acetyl-CoA-carboxylase]
                     synthetase/biotin operon repressor"
                     /protein_id="HEV0770772.1"
                     /translation="MKSYQAVYQILSKETDYISGEKIAEKLSLSRTAIWKAIKRLEQE
                     GIEIDSIKNRGYKLMNGDLILPEILEENLPIKVSFKPETKSTQLDAKEAIDLGHEANT
                     LYLASYQTAGRGRFQRSFYSPQGGIYMTLHLKPNLPYDKLPSYTLLVAGAVYKAIKNL
                     TLIDVDIKWVNDIYLNNHKIGGILTEAMTSVETGLVTDIIIGVGINFTIKDFPQELKE
                     KAASLFKATAPITRNELIIEIWRAFFETPAEELLYLYKKQSFILGKEVTFTLEQKDYK
                     GLAKDISENGKLLVQCDNGKEIWLNSGEISLNSWK"
     gene            complement(67433..67520)
                     /locus_tag="VXE25_000243"
     tRNA            complement(67433..67520)
                     /locus_tag="VXE25_000243"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(67484..67486),aa:Ser,seq:gct)
BASE COUNT        20180 a        15113 c        12413 g        19818 t
ORIGIN      
        1 ttatttcatt ttactatact ctgttaattc atatgagttt aaaccgattt catctttaac
       61 ctcgagtaaa gcagtttcaa atatttgttt aagagttttt gattctttac aattaaccga
      121 caaactttct gataaaatat gtacaacttc tgagactgaa taacctatct cctctttaga
      181 attatataaa tctgtagctc caccaataat ccaaaaatac tgattttgtg aacctacaat
      241 atcctcattt tctacggaac ttccttgtat cgaacaaatt ttatttatct ttaccataat
      301 acttcaaccc ttttagtgtc aaaagtaaac caattcctgt cactgttaag aatagttcca
      361 taatcttgtt cgaaccagtc tttggtaatt tttgttttac atctactatt tctttagatt
      421 tattaatatg attttcagtt tctctgccat ctccaactat tttatagttt acttcttctg
      481 tcttattatc ttgtttattg tcgatcttgt cattcatttg tctattatct ttacttgagt
      541 taaactctcc gttcttctgg ttactatcaa ttacattatt tgaattagat tgtttttcct
      601 ctttgttttt ttctttttcg tttttatcac ttaaattatt tgttacaata ttgtaaagcc
      661 cattctccgt tacaatattg aaattaccat cgctatcacg tataacaggt tctttcccat
      721 ttgcattaga tttgatgaat gatatatact taccggataa attataaaat tggttattta
      781 aaacggttat tttacccttt gaatcctcaa taacaattcc ttctttaccc ccgaatatac
      841 tattctctga gactactaaa ttatcactaa ctcgtaataa ttcaatattt ggttgttctg
      901 tttccttaga attattatta attacatttt ttgttacagt aatatctgat acttttccta
      961 aatattctgc actatctttt gcaactcgta tcgcttttgt tttaggatcg gcaatattaa
     1021 atatattttc ggcgataacc acctgtttat ttaaatctaa taggtcttta gtgtttttat
     1081 agctataagc atttactaaa gctgctccgc tttctcgata atgtacactc tctcctttaa
     1141 ctttcttatc aaagcgattt cctttgatta atacatcagt gaatcctgta aaacgtacac
     1201 ctgcatacat catgttatca aaatgattat ttaaaatttt aatattagag gggttctgtg
     1261 tcgacaatgt ttgatagtgt gtgccaattg ctgttactaa ttccccagat ttatcacttt
     1321 tgccaaaata ggaattttga atagtcacat tttcagattt tttcccatca tcattcaagg
     1381 cataaggaaa accttttcta gttaatggtt caatctgaat gctctcctta cttatgattt
     1441 gcccatcctt catcgttttg ggtaaggctt gcccaagaaa acgagaatta tcaactaata
     1501 catttttcga acctgcaatt tgaatagcat gcccttgata actatccttg aatgttacat
     1561 tttttatagt tacgttattt gaattcccaa tagcaaatgc acctgaagaa tttataagtg
     1621 gtagattttt tgctttagtt ccttcttcat tcaaagcacc gttcatatca atcgtaccac
     1681 cagaataact aatatcttct gttgggcccc attctacttg cgcaccatca tccgtaaata
     1741 aacctgtcat aaaaacaatg gaagggtgat tcttaatatt tataccattt agaattgtag
     1801 ctttctcatt caattctaag tgtgtatgac tttttaaaaa aacaatttct tttactaaat
     1861 aagttccttc aggaaaatat acatttcctc cacctagccc ttgagctgca gcatctattg
     1921 catcttgaat tgcttgtcga tcatcatgaa tcccatcacc taccgcacca taatctttta
     1981 cacttaaagc agtatcttca aattcttttt tgataattct gtcacttata acatcttcct
     2041 tataactctt attttcatta gtagatgtta ctgtagattc aactgttctg ttgtctaatt
     2101 gtgaattgga acgaatagta ccattagagc tgatactatt aacacttaac gaattatcta
     2161 aaccattagt ggttgaatta gaggcaatca tttcagcaga acgattctga ttaacagttg
     2221 gtgaattatc taaatcatta gtaattgcat tagaagactc ttttgtagcc atcggtgaag
     2281 aactagtaac aacttcatcc gataaaatac cttggcttcc caaaattgaa attgccaata
     2341 gtaccgagca agtccccacc tttaatttac gaatactgaa tacctcatta ggaacaaaat
     2401 atttcatcag aacctccaat ttttttacta tttttaacaa ttgattatta cttttcttaa
     2461 aatagataga atgacaccgc tgtcattatc tttatcatat attttccaaa ttgaattgtc
     2521 aaggaataac acaagaaaat attaaaattt atactcttcg gaaatctctt caaactaggt
     2581 cagtgccgcc ttgccctaag tctaggttac tgacttggtc agttctatag tagactgaaa
     2641 ctaaaatagt acacctctac ttctaaaaca ttgttagaaa tcgatttgac tgtcccgatc
     2701 aatttgtcct attcttattt cattttacta tatctacaac ctcaaagcag ggttttgagc
     2761 tatctatggc caacttccta gtttgctctt tagccttcca ttcaaaagtg atgctatctt
     2821 tcttagcttg aatataaaat atcccattta ctatatttaa atttgttgat atgttgtaaa
     2881 ttataaatga aagaacaaat accttgtcat acaagcattc gccagggata tttacctgaa
     2941 tatcgctcat atggcggatt gaaactaaaa cactacaata tatttcttaa atagaccttc
     3001 tataaaagct agatttaacc tcgataaaaa tagatgcagt gcttctaaaa tactggaata
     3061 gggcatatag gtaatcgtag acaagtgttt tatagattgt ctcgcaggag atctaatgat
     3121 gtatagcaag catcactaaa catatagaat atttgtatta ttataatatc aacatgctat
     3181 aaattctatc atgcaaaaga atgactagaa catgaaagac aggcacaaaa ttttgaacaa
     3241 tattctgaaa acaaaaaaag acgcgagttt ccacaatctc actcatggaa actcacgtct
     3301 ttcaaaaaat agggtgaatt gaaaactaga acaagacact agattttcta aatgatgtct
     3361 agtaaggatt ctaaatgcta cactaaattg ctcacatctt atttcaaacc acgggactcc
     3421 cacaagaaag gaaaatccta taaaaattct ctctctgagg agaaagaggc ctcaactaca
     3481 ggtgtaaact attatcaatt gaaaacaaca gtttttacac tcaattagac tttttaggga
     3541 caggatcact ttcgcttgac tgtagtttgt catttttttg ataaagttag cactttttca
     3601 gaaactgttt tgaaagtctc aatgatatag tctacttctt catcgcttaa tttagtatga
     3661 agagggaggg taatttcatt ctcaaagaag gcataggcct taggatagtt cgtcatatca
     3721 aatccaagat tcttataggc tgtcaagaga ggaagcggtt tgtagtgaac attacttgca
     3781 attcctgctt tagccaattc ttggatgatg aggttgcgtt cttctaggct tgctccttct
     3841 acacgggtga tgtagaggtg gcgtgaagat tcgacagttt cagtcttgtg tgccaaagga
     3901 tggatgcgag aacctgcaaa accactatca tagcggtcca caatgtcctt acggcgttgc
     3961 aacaaacttg gatagcggtc caattgtacc aaaccaagtg aagccatgat atcggtcatg
     4021 ttgcacttat aggctggtgt aacgatatcg tattcccatg accccaattg catcttggca
     4081 agagcatcct tagtttgccc gtgaagggaa aggatttgga attccttgta catctcttcg
     4141 tcatcaatca ctggattggc tttccaagtc gcacttccac cttctgccgt tgtaaagttc
     4201 ttaacggcat ggaatgagaa ggaagtaaag tcagcgatag aaccagaagg ttgtccttta
     4261 taagtagatc ccaaagcgtg ggcactatca gagacaatga caatacggtt aaaggccttt
     4321 tgccacttgc ttgaagcggt aaagaagtca cgttttttct ccacgacttg gaacaaacgg
     4381 tcataatcgc aaacaatccc tgcgagctct actgggataa tcaccttagt tttctcagtg
     4441 atagcttgct caagcaggtc atagtccatc tcaaacgtat ctgcttggat atccaccatg
     4501 acaggggttg ctcccacgtg cgtaatgaca ctacatgaag ccgtataggt catggctgga
     4561 acgatgactt catcaccagg tcccacttcc aaaacgcgta aaatcaactc cagagcggct
     4621 gtcgcagagt tgagacaaac agtcttaggt gtctgtgtgt aaagagacaa gcggcgctcc
     4681 agttcttttg ttttaggacc tgttgtgatc caaccagaac gcagggtatc cgctacttca
     4741 gcaatttctg cttctgtgat atcaggcggt gaaaatggaa tattgtaatt tggcattgat
     4801 ttgctccttt tatctgtact cattttctta tgactacttt attttagtac ctcaaacacg
     4861 gtttgaaaca tgattttgat gtccccaaag aaactaaact ctcggagata ggcgaggtta
     4921 tagcgcatct tttcaggaag aacatgctcc acataggcct gatcaactga cagacctttc
     4981 tccgtcattt gactgatgat ggtgtcctca tccttgtagt tgatgctggc tggagaggta
     5041 attcctgctt gcaagagcaa ggttgccatc atttcagggc tatactgctc tgtataacgt
     5101 ggcacttcag gtcgtgtacc gacaaaggac atctcacctt taaggacatt gaccaactga
     5161 ggcagttcgt ccaaacggac acgtcggatg aaatttccaa ccttggtaat acggctatcg
     5221 ttagcagaag tcaccagact tcctttttta tccgcatccg tcaccatggt acggaacttc
     5281 caaatcttga accgacagtt gtactgggtc acacgctctt gcttgtaaat cactggcccc
     5341 ttgctatcca acttgatcca aatgctcaag atgagaaaga tgggagaagt tagaaccagt
     5401 aagaccaagg ccaaaaccca gtccaagcaa cgcttgaaaa tcagcgaacc cttcctttta
     5461 gagacaagct ggtagtaaga ctcaacctcg cttgatttca tttccacagg caagtcttcc
     5521 catttcagca tgctgttctc ctttgttttt attatactat ttgtcaacat ttttcattat
     5581 accacaaaat ggaaaaggcg gtgaaagaaa tctgtaattt gaaggatttc cttctagtac
     5641 tcaatgaaaa tcaaagtaca gctttgagat tgcagataaa gctgacatgg tttaaagaga
     5701 ttttcaaaga gtatcggcca tggcccctgc ctgcaaacta tacatcttgt gataagttcc
     5761 tcccagagcc aagagttcct catgggttcc actctcgata atgcgtccct tatccaagac
     5821 atagatgcag ttggcgtctt gaatagtaga aaggcggtga gcgatagcaa tagttgttcg
     5881 gccctgtctc atcttcgcca gagaagcttg aaccaagctt tctgtttcag agtcaatatt
     5941 ggctgtcgct tcatccaaaa tcaggacttt aggctggctg gcgactgttc tagcaaaggc
     6001 aagaagctgg cgctgcccag tagagaagct cgaaccacgc tcggaaacag gggagtcgta
     6061 cccctgagga agttcttgaa taaaggaatc tgcatccaca aaggctgccg cagcctgaac
     6121 ctgctcatca ctgatttctt ggtacatggc aatattggac ttaatagttc catgatagag
     6181 gaagggttcc tgcaagacca aaccgatgtt ttttctcagc tcttcttgac tgaaatccct
     6241 gatatccaca tcatccaaga gaactctccc tgactggaat tcataaaagc gcatgaggac
     6301 attgataata gacgatttcc ctgaacctgt atgacctaca aaggcaatgg tttcaccctt
     6361 attaacagag aaagaaatgt catccagaat cggatgttta ccgtcatatg agaaacacac
     6421 atgttcaaaa cggatattgc cttcttggac tttggcttgc ccattttctt gaagaggttc
     6481 ataggtcctc tcgtctatca gggcaaagac acgacctgca gaaaccatag ccgtttgcag
     6541 agttgaaaag ttttgcgtca cctcaatcaa ggggtcaaaa aggcggttga tgtactggat
     6601 aaaggcatac atggtcccga ccgttatccc gatagaaaaa ccacggtagc caaagtaggc
     6661 catcaagact gcatagccta gaagtttcag caaactcatg gcaggtctca aaaagagggc
     6721 atccaaggct acagaacggt tggcgtagac caagtgttct tggttgattt catcaaattc
     6781 tgcctgcagg cgcttctctt gattaaaagc ctgaataatc ctgattccct cgatattctc
     6841 tgccagctta ctattgatat ctgacaagag acttctggtt ttctcgatga ttttcactga
     6901 cttttttcga tagagattga ccaaaaggaa aatcaaagga agaaagagca agactaaagc
     6961 cgtcaaacga aaatccagca ccaacatggt ataaagggtt gtcagaaaga taaaaactgc
     7021 tgagataaag ctggataaaa tcccagaaaa catatcacta atcgtctcgg tatcgttggt
     7081 caaacgagaa acgatagaac ctgctggcgt cttgtcaaag taagacatgc ccagtttctc
     7141 catattggca aaggcatccc gacgaatatc cctaacaata ctgtaagaca cgcgcgcaaa
     7201 gagaagattg cctacatact gaactacagt ttgtaggatg tagagaccat agtagaccag
     7261 caaaacggta acggctagtt ggttaagatt gctgagatac tggtcgataa agtgggaagc
     7321 cacgaggggt atgacacttt taatgaccgt cgtcgctagg agaaaactga gtgccaaaaa
     7381 gatcaggagt ccataagact tgagataaga catcaagcgc ttcaatacag cccattgttc
     7441 ttgtttattc tgcatcttct tctcctttca tttctaactg ctgagactgg taggtttggg
     7501 cataccagcc atccatcgct agcaagtctt cgtgcctgcc tcgttcgata atttgaccat
     7561 tttgtagaac taaaataaaa tctgcatgga caacagcact gaggcgatgg gcagtgataa
     7621 tggttgtctt gtcctttcgc gtctccttga ggttgtcgat aatcgcatac tctgtcttgg
     7681 catctacggc ggataaggaa tcatccaaaa tcaagatatc agggtttaaa atcatagccc
     7741 gactcatagc caaccgttgc ttttgaccac cagaaagact gactcctttt tcaccaatca
     7801 gcgtatcaaa tccttgaggc atgtctacaa tatcttggta aactcgggct agcttagtag
     7861 cttcctcgac cgctgaaagg ggcaagttag gattgccaaa gcggatattg tctaggattg
     7921 aagttgcaaa gagaaactgg tcctgaggaa catagcccat gagactgcga aggtctgtca
     7981 gacgatagtc ccgaatatcg tgaccgttta gataaatggc gcccttatcc acatcgtatt
     8041 cacgcaagag aagcttgatt aaggacgttt tcccagagcc tgtctgccca accaagccca
     8101 gtgtttgccc ttttgccaaa ctaaagtgaa tatccgtcag tgtttcctca ttttcaaaag
     8161 caaagctgtc aatggcatac tccaaacgcc cattttcaat accatccaga ggaaactcag
     8221 ggtcttgtac aggagattcc tgagacaaaa gattttcaat ccgctggtaa gaaaccttcc
     8281 ctcgctgagt agtattaaag aggaagccga tggccataag aggccagacc agcatatcca
     8341 aatagctgat aaaggtgacc agattcccaa ctgtaatctg cccttcctga accatcaagg
     8401 agccaaccaa aagcgttaaa acataggacg aaccaacaaa caagagaacc atagggtcaa
     8461 agagactatc atatttcatg gtttgcaggt tcttttggaa ggttaattca ttgactgcct
     8521 gaaaagactt caactcgtct gcctgataac cgaaagactt ggtcactttg atacctgata
     8581 cggactcctg taccttgtta ttgagttcag aaaaagcagc ttgggattcg ccaaaggcct
     8641 tatgagtctt tctccctagg cgactagtcg cataggccat gaaaggtagg gggagaatgg
     8701 caacaagagt catctgccat gagatgctaa agagcatggt caacaaagtc accagagccg
     8761 tgatagaggc atccaccgca gacatgacac cgccacctgc taaacgagtc aaggcattga
     8821 tatcattggt tgcgtgtgcc atcagatcac ccgtccgata tgtttgataa aaggctgacg
     8881 acatttttgt gaaatgctta aacaagcgag accgcatgat ctgtcccaag caataagagg
     8941 tcccaaggat atacatacgc cacacatagc gcaaatagta cataccaaag gctgcaagta
     9001 gcaagtaaaa taggctaaga aggaggtcct gctgggttaa ttgccccgat gtgatggcat
     9061 caatgacccg ccccataacc ataggaggaa tgagattgag gacggaaacc aagatcaggg
     9121 ccacaattcc gactagataa cggcgttttt ctaacttgaa aaaccaccaa agtttttgaa
     9181 taatggacat aaaatccctt tctgattgca aatggaaacc tgaggccaat actcaatgaa
     9241 aatcaaagag caaactagga aactagccgc aggctgctca aagcactgct ttgaggttgt
     9301 agatagaact gacgaagtca gtaacctaca tacggcaagg cgacgttgac gcggtttgaa
     9361 gagattttcg aagagtacaa gaccccaggt ttttcttatt cataagttac gactgtaaca
     9421 gcacccttgt catattcagc aataaagata ttggctacat tgtcatgccc ttgtttactg
     9481 aggttatcaa gcaaccactc ttcgctacga ccaatcgatt ccaagacatc tacttgaatc
     9541 acaccgtcag tcacaactgg atacttagga ttttcatctc ccatttgcac aacgatgagt
     9601 tgcccatttt gctcttgcac agctcgtttg acttgcttca tctggaaaat cccttggcta
     9661 cgaagtttga gggatacatc cgatgcagac aaaccaactg aacgacaggc ttctgggtca
     9721 atattcccat ttttgataag gagagttggc ttaccatcaa tcaaacgttt cacaaagtga
     9781 acattgttgt tgagctattt gagagtcaag atcagtttga ttaaaatttc gatataatta
     9841 agtgtcattt gttcacatcc accagttcaa ttgcgtctgt cttatacaat tcgactttct
     9901 ctaacaggta cttgtctggc tcacttccgt ttagggcacg ataatagcga tctcccacct
     9961 tgataagtgc gccatctgtg tttgtggaag tattaacata gacttctgac ttgtctactc
    10021 ccaaatcttt ggaaacaacc tcgatgaaat gaagtgaagt ttgaaattta ttgttagaaa
    10081 cttgattgtt ttgataagtc gtgatgctga ccaaaagcat agctaaataa ggccagagct
    10141 gaaattatga ccaactcacg aaatttggtt ccttttttat catggtatgc cttgaaagca
    10201 aaaaaaactg tcacagctaa taaaacaatc ccaaagccaa ccatgatacc attttgctga
    10261 ccgatttggc tgagtacata gtcataagag tagaatttca tgtattttca ctccctttca
    10321 taaaatcatt cttaattata aacgaaagag agtaattttt caaaccatac gttggggaaa
    10381 tagatctttt tttggtataa taaaatctat aatctgaatg aaaaaggtaa ctttatgaaa
    10441 cttatctcat ggaatattga ttccctaaac gctgccctaa ctagtgactc agctcgtgcc
    10501 aaattgtccc aagaagtcct acaaaccttg gtcgctgaaa atgctgatat cattgctatc
    10561 caagaaacca agctttctgc caaaggacct acaaagaaac acgtggaaat tttagaagaa
    10621 ctcttcccag gctacgaaaa cacatggcgc tcttcccaag agcctgcccg taaaggctat
    10681 gctggaacca tgttccttta taagaaagaa cttacgccta cgatcagttt tccagaaatc
    10741 ggtgcccctt ctaccatgga cttggaaggc cgtatcatca ctctagaatt tgatgcattt
    10801 ttcgtaaccc aagtttacac tccaaacgct ggtgacggtc tcaaacgctt ggaagaacgc
    10861 caagtctggg atgtcaaata tgcggagtat ttggctgaac tagacaaaga aaaaccagtc
    10921 cttgcgaccg gtgactacaa cgtagcccac aatgaaatcg accttgcaaa tcctgctagc
    10981 aaccgccgtt cacctggatt tactgacgag gaacgtgctg gatttaccaa ccttttggca
    11041 actggattta cagacacctt ccgccatgtt catggcgatg ttcctgaacg ctacacttgg
    11101 tgggcacaac gcagcaaaac ttctaaaatc aacaatacag gctggagaat cgactactgg
    11161 ctcacaagta accgtatcgc tgacaaggtc actaaatctg atatgattga ctcaggtgct
    11221 cgccaagacc atacaccgat tgtcttggaa attgacttgt aaggattttc tatatggact
    11281 acaatgcggt cattcccgag tttcttgtat cgaatatcga acagtcccgg tccttctact
    11341 gtggtttact gggttttagg attgaatact aacgtccaga agaaaacttt ctctttctct
    11401 tgaagagtgt caactaatgt tagaggaggg aacaaaggat caactagctg aactgaccta
    11461 cccctttggt cgtggagtca atctctcctt tggcataaag gatgttccaa aactctatca
    11521 aaaagtgatg gaggcaaact atcctattta tcgtctcttg accaaaagaa agtttcgtgt
    11581 cagtgatccc tatatctatc ctcataaatt tgcagttttg gatccagatg gctatttttt
    11641 aagatttagc gagtagaata ataaaaattg ggaaaagtct ttaaagttag aaaaaggcat
    11701 attgtcaggt gtctaaaaac ttgatagtat gccttttatg atggaaaaat cttctaatac
    11761 tcttcgaaaa tctcttcaag ccacgtcaac gtcgccttac cgtaggtata tgatactgac
    11821 tctgtcaatt ctatccacaa cctcaaaaca gtgttttgag gttgtggata gcttcctagt
    11881 ttgctctttg attttcattt agtataaatg ttagcttaca acggagtttt tgttcaccct
    11941 ctcttctttt tgttcgcttt ttaaaccgaa acactaacaa aatagttgat ttataaagtt
    12001 atttagtgta aaataaaaac attggctcaa gcctatttaa aattgaatat cgttttactt
    12061 gtttatgtcg tgaattggca cgacgtttct acaaggtgcc ggaacaccta acaataagta
    12121 agtcagcagt gagatatggc cgtttttgcc atgtctattt aggggactta cttagagatt
    12181 aagtaggtct tttttgaata tttttaatat ttcccttaat tagtgcggac gggaggtgaa
    12241 attatcctgt gaataatttc aggaatccag ggaatttcat ccctaatttt tgagccccta
    12301 gctctttcat ttctaggctt aggctaaaat agttccccga actattttac tctcaaaaat
    12361 cccgtcatag acaataacaa gattattgtc tatgatacca ctacaacggg aaatatttga
    12421 taagactcgc ttcgctcgta atagttttat caaatatata gtattagcaa aagggatcac
    12481 tatagaaata tttaaacaac aagtaaatta acttttagac tttaggaggt cttatgaaat
    12541 tattagaaga gcgcatcctc aaggatgggc atatcttgga tgataacatc ctcaaggtag
    12601 attccttttt aacccaccaa gttgacttta gcttgatgcg agagattggt aaggtttttg
    12661 cggaaaaatt tgctgctgcc ggcattacca aggtcgtaac cattgaagcg tcgggtattg
    12721 ccccagccgt ttttacagct gaagccttaa acgttcccat gattttcgcc aaaaaagcta
    12781 agaacatcac catgaacgaa ggcatcttaa ctgctcaagt ctactccttt accaagcagg
    12841 tgaccagcac tgtttctatc gctggaaaat tcctctcacc agaggacaag gttttgatta
    12901 tcgacgattt ccttgctaat ggccaagctg ctaaaggctt gattcaaatc atcgaacagg
    12961 ccggtgccac agtccaagct atcggtatcg tgattgagaa atccttccaa gatggtcgtg
    13021 atttgcttga aaaagcaggc taccctgtcc tatcacttgc tcgcttggat cgttttgaaa
    13081 atggtcaggt cttatttaag gaggcagatc tctaatgcaa actcaagaaa aacactcgca
    13141 agcagccgtt ctgggcttgc agcacttact agccatgtac tcaggatcta tcctggttcc
    13201 catcatgatt gcgacagccc ttggctattc agctgagcag ttgacctacc tgatttctac
    13261 agatatcttc atgtgtgggg tggcaacctt cctccaactc caactcaaca aatactttgg
    13321 gattggactc ccagtcgttc ttggagttgc attccagtcg gtcgctccct tgattatgat
    13381 tgggcaaagc catggtagtg gcgctatgtt tggtgccctt atcgcatctg ggatttacgt
    13441 ggttcttgtt tcaggcatct tctcaaaagt agccaatctt ttcccatcta tcgtaacagg
    13501 atctgttatt accacgattg gtttaacctt gatccctgtc gctattggaa atatgggaaa
    13561 taacgttcca gagccaactg gtcaaagtct cttgctttca gctattactg ttctgattat
    13621 cctcttgatc aacatcttta ccaaaggatt tatcaagtct atctctattt tgattggtct
    13681 ggttgttgga actgccattg ctgctactat gggcttggtg gacttctctc ctgttgcggt
    13741 agctccactt gtccatgtcc caactccact ctactttggg atgccaacct ttgaaatctc
    13801 atctattgtc atgatgtgta tcatcgcaac ggtgtctatg gttgagtcaa ctggtgttta
    13861 tctagccttg tctgatatca caaaagatcc aatcgacagc acgcgccttc gcaacggtta
    13921 ccgcgcagaa ggtttggccg tacttctcgg aggaatcttt aacaccttcc cttacaccgg
    13981 attttcacaa aacgttggtt tggttaaatt gtcaggcatc aaaaaacgcc tgccaatcta
    14041 ctacgcagct ggtttcctgg ttctccttgg actgcttcct aagtttggtg cccttgccca
    14101 aatcattcca agctccgtcc tcggcggtgc catgctggtg atgtttggtt ttgtatctat
    14161 tcaagggatg caaatcctag cccgagttga ctttgctaac aatgaacaca acttccttat
    14221 cgcagctgtt tcaatcgctg caggtgtcgg tctcaacaac agtaatctct ttgtcagcat
    14281 gccgacagcc ttccaaatgt tcttctcaaa cggaatcttc gtagccagcc tactcgctat
    14341 tgtcctcaat gccgtattaa atcataaaaa gaaataagaa aaagaggtgc gagcctcttt
    14401 tttgtgtgac aaaataaaaa catctaccta ttcatatatg ctagtgtcat agtcctgaaa
    14461 atcatctgca tcaagaacaa tttcacaact cttatacttt tctcttacaa gtcgttcggc
    14521 ttcatctgga ttttcagcct ctatacttac taaacgtgat aaagtttctg taatttctac
    14581 tgtatacttt ttcagtttta gattgctttc caataattca cctattaaca ataatctatg
    14641 ataggagcta tgtagccact ctggcaattt atctcctact tcccacccat atttttcctt
    14701 catcaaagct agttgttttt cgtcaccaaa tttcatattt tcagataacc atctcacaca
    14761 atcgggatct gataaggtac agacgattaa acttaggtta tcgtaacggc tttcagtttc
    14821 ataatcaggc cagatgactt ttaagaaatc atacacctct tctgatgcaa caagttgttt
    14881 cgttttcata atttccgata ctttcctcta cctttaaatt ctattatttc tttgtctctt
    14941 aatatttgaa gctgttgcct aatcttttct ttgatatgat tgttcttaac aaagatattt
    15001 tttaggtcac tttcaaaacg atacatatct tcaagggtaa attctgaacc ctctatctta
    15061 tctatacaat ttagaatttc tattgtccaa cctcttgatg acagagagct cttccttaaa
    15121 aataaacctt gcttaaattc ttttgtaact ttttctggat ctctaacttg tccatcttgc
    15181 acaagaaata tccttccttt agaaggtact tgtgataaat caatgttaca accaatccaa
    15241 cctgctcgtc tagcagttgg tgcaagtggt tttctttgaa taattgattt cggtgtaaca
    15301 aattgcttcg gaaggacaag aaagttattt acctcaaaat tttttgtgta agttaaaaaa
    15361 aagaaattag gattattatc tgcctgcaca cgcttcatca tcgttgcata agcaccatca
    15421 ttgattgttg atgaaaaatt tccttttttg ctctttagtt caaactcctc actacaatga
    15481 ttacagtaaa aatctgctac aggccgatta ttttcaaaat gatttaaggg attgttccca
    15541 caattagggc aataagactg acgataaacc caatcctccg ttaagatacg tgccttttgg
    15601 ctattacttt tataggtttc tactaattct aaattaaagt gtaattccat ttaaaaattc
    15661 ctcactaata tgagaactca ctcgatataa gcaattaaaa tctactataa ctagtatacc
    15721 acatatatgt acctattaca tttgtatttc accactctct tttatatttc cttctaacat
    15781 atctcataaa ttaaaaatga gtgagataaa tttatcccac tcacctttct ttatatcctt
    15841 acccgtcttt cctcagacct ttggcctgtg acaaacatgg taaaggttgc tttacagaca
    15901 tttctgccct cttgattggt gatatccaca tccatcacac aggttgtacg accttgatgg
    15961 acacattctc ctttaatggt caatacatcg tcgagttttc ctgccttaag gtagttgata
    16021 gaggattgga gtgtcacccc atcaagtccc agcgagataa ccaccaaacc actgatttgg
    16081 tcacatagcg tgaatagata gccaccatgg gcattgccat agtagttgag cgacgagttc
    16141 actactttgg tcgtcaccac aacgtgacca tctctcattt tttcaatttc gtaattttca
    16201 aaggcagata tagcgtcaaa atgaaagtct ttcatcgttt cctcctgata tttcaaacga
    16261 cactatgata ctacttttta taggactgtg caaggagaaa gctcctagtc tagtgaaatt
    16321 ccgacctgtt ccacaaagcg cataaaggct gtctgccctt gttctgtctg cttgtagact
    16381 cctgcatcct caagtacacg cacaaagata gcacccacag agtccttgac gattgcaagg
    16441 gctttttctt tatccgttag gtctggatgt tgggatttga gttggtctgc ccactcctga
    16501 tgataatcgg caactgtaac agcttctcct acaagatagc tagcgacttg ctccacttct
    16561 tctttcagac gtggtggcaa gattgccaag cccatgacct caatcaagcc gatattttcc
    16621 ttcttgatat gttggacatc cttgtgggga tgatagatgc catcaggatg ctctgctgaa
    16681 gtctgattgt ctcgcaagac caagtccaac tcaaactgtc catcacgctt acgcgctatt
    16741 ggtgtgatgg tgtgatgcgg cgtcccgtct gtctctgcta aaatctgcac actagaatct
    16801 gaatactgac gccattcctg gaaaatctta tcagctaagt taatcaaatc ctctttggaa
    16861 tccgaagtca agcgtaggac agacattggc cacttgataa ttccagcctt gacctgctca
    16921 aaaccagcaa atcggaaggt cttttgcaag ggagccaatt ccataggaaa tacgtgacgg
    16981 cctccctgat aatgatcgtg agttagaata gagcccccca caatcggcag gtcggcatta
    17041 gatccagcaa aatatcctgg aaactgctct acgatagcca acagacgttc aaaactctga
    17101 cgactaatgg ccatgggacg atgctggcca tctaaaaaga tacaatgctc attaaagtaa
    17161 gcatagggcg aatactggaa cccccattcc tgaccaacca tttcaaaacg gataatccgg
    17221 tggttgctgc gagctgggtg gttgacccga ccatggtaac cctcattctc taaacaaagt
    17281 tgacactgag gataattact agcttgcacc aacttggcta ccgcaatctc tttcggatcc
    17341 ttttcaggct tagagagatt gatggtaatt tcaagttctc cataatcaga tggaacacga
    17401 taagcgatat ttttagcaat ggccttgagt ttgatgtagt catttttctg actgagttga
    17461 taaaaatcct ctatcgcttg ctcaggagag taggcatagg cttcccagaa gtcacgattg
    17521 acctgactcg gacaaggagt caccaagtcc atcagttcag taccaaggat ttcacgcgca
    17581 gtctgactat cctcaatcgt ctctaatcga acggcttcct caactagctg ggccttgagg
    17641 tcaatcaatt tatccagatt ggtctcaact tccaaaacac cttctcccac tcgtgccaaa
    17701 acacgattgg tcaggtagat tcgatccatt tcctcaaatg aactttcaga aatgacatgt
    17761 gttacaaatt tatctactaa ggtcactata gagcctcctt ttgactagtc aaggacgcga
    17821 gtgccacctg caacttcagc gatatagaag cttggagcgt atccaactac ttcctcgtag
    17881 tgtttgccta cagcttcctt aaaggcctca acagtatctt tttgaaccaa ggcaatggca
    17941 cagccaccaa aaccagcccc tgtcatacga gcaccgagaa ctccttcttg tgcccaagct
    18001 gtgtgaacaa gggtatctaa ttccaaacca gttacttcat aatcatgctc cagagaaacg
    18061 tgtgacgcat tcatcaaacg accaaatgtt tccaaatcac ctgcttgaag ggctgcttga
    18121 gctttaaggg tacgttggtt ttcaagcaca gcatggcgag cacgtttcaa acgattttca
    18181 tctttaatta gatagctata ttggtcaacg gcccactcgt ccaattcacc cagggtctga
    18241 atatccaagg caacttgcaa ttcttccact gctttttcac actcagcacg acgttcattg
    18301 tatttagagt ccgccaattc acggcgtttg ttggtgttca tgataacaac gacattgtcc
    18361 ttcaaatcaa gtggcaccaa atcatactct aaggtgttgg tatcaaggta aatagcacgt
    18421 tgatcagccc ccataccaat agcaaactgg tccatgatac cagagttgac tccgataaag
    18481 ttgttttctg tttgtttgcc gattttaacc aaatcgagac gctctaattt taaatcaaag
    18541 agatgctctg ccacgactcc tgtcaagagc tccaaggatg ctgaagaaga caagccagca
    18601 ccatttggga tattcccata aacataaaaa tcaaaacctt tgtcaatcac gtgcccagct
    18661 tcttgcaaga aatgaagaac cccttttgga taattggtcc agttgtgctc tttttcaaac
    18721 ttgaggtcag cgagaggcac ttcgataatg cccttgtcct caaagttagc tgagtagaaa
    18781 cgcaagactt ggtcgtcacg cttacgagct gcaccgtaag ttcccaagga aatagcagca
    18841 ggaaaaacgt gcccaccgtt gtagtctgtg tgttcaccaa tcaaattaat acgacctggt
    18901 gaaaagaagg tttggtctgc ttcttgacca aaaacagcaa gaaagtcttt gcgaaggact
    18961 tcagtagtaa gatgttgtgc catatgaatt ctcctttgac tgtccgttaa gccatcttaa
    19021 cgtgtaatcg ttttcttcta ttgtatccaa ggaatttccc aaggtcaatc ctttttacta
    19081 aaattttagt aaaacatcag taaaaagaag aaaaatatga tatactaacc taatcaagga
    19141 ggatttatgg ctaccttaaa agacattgca cagctagcct ctgtctctat cgcgaccgta
    19201 tcccgtgtcc tcaaccgcga ccagagccta tctgttacag aagaaaccag acaccgtatt
    19261 ttaaccgttg ctgaagagct gggctacacc aagcacctca agacaggcga gtcccataaa
    19321 cccaagcaaa agattgccat tattcaatgg gtcagcgaac aaggggagct agacgacctc
    19381 tactactacc agattcgcct aggaatagaa aaaagagccc aagagttgga ctacgatatc
    19441 ttgcgctatt ttaatgacca tccttttacc ctaagcgagg aagtgattgg gattctctgc
    19501 atcggaaaat ttagccgagc tcagatttct gcctttgaag aataccaaaa gcctcttgta
    19561 tttctagaca gcgatacact ttccctggga catacctgta ttatcacgga tttttacact
    19621 gctatgaaac aggttgtcga ttatttcctc agtcaaggga tggaccgcat cgggattcta
    19681 acagggcttg aggaaacaac agaccaagaa gaaatcattc aggacaagcg tctagaaaac
    19741 ttcaaaaact acagtcaagc gaggggaatc tatcatgatg aactggtctt tcaaggaaga
    19801 tttactgccc agtctggcta tgacttaatg aaggaggcca ttcagagctt gggagaccaa
    19861 cttccgccag catttttcgc agccagcgat agtttagcta tcggtgccct ccgtgccctc
    19921 caagaagctg gaatcagcct gccagatcgc gtcagcctca tttcattcaa cgacaccagt
    19981 ctgaccaaac aggtctatcc tcccctctct agtattacag tttatactga agaaatgggg
    20041 cgagcaggta tggatattct taacaaggaa gtcctccacg gtcgcaaaat tcctagcctg
    20101 accatgctgg gaaccagact gacattaaga gaaagtaccc taaatcaaga ataggataac
    20161 ataaaaaacg aatagagttc taaaactcct attcgttttt tattcgatta caatcataga
    20221 cttaattgtc ttacgttcat ccatatcttt ataggcttgg tcgatatctt ccagtttata
    20281 acttgaagta aagacgcgac ctggattgat atcaccatca aggacggctt ttagtaaaaa
    20341 ttgcttatcg tatgttgtag cagaagctgc cccacctgct acagagatat tttgcataaa
    20401 tgtcgaacca agagcacgat tattatagtg tgggactcct acaaagccca tacgccctcc
    20461 attatgaaga acacctagcg cctgttctat agcagcctcc gtaccaacac attcaagtgc
    20521 tgcgtctgct cctccgccga ggatttcacg caccttggta attccttctt gaccacgttc
    20581 tgcaacaaca gctgtcgcac ctgactccat agccatcttt tgacggtctt catgacggct
    20641 cataaggata atttgtgatg ctccacgcat cttagccgcg atgacagcac attgaccaac
    20701 agccccatca ccgataacaa caaccttgtc ccctttttga acatttgcaa cacgcgctgc
    20761 atgatagcct gtcggcatga catctgcaag agtcaaaagg gacttgagca tcccttctgt
    20821 ataatcagaa ggttgaccag ggattttaac cagcgcccag tttgcatagt ggaagcgaat
    20881 atattctgcc tgaaaatcac cccccaaatt attaccaata tgattgtcgc aagaaccgtc
    20941 aaatccagca agacaggcat cacactcacc acatccatgt gtaaaaggga caatcacaaa
    21001 atcacctggt ttcaccgtcg taatggcttc cccagcttct tcaacaatcc caatcgcttc
    21061 gtgtccacta tttttatgtc cagctttcgt ttctggatta cggtacctcc ataaatctga
    21121 accacaaacg cacgcacgaa ccacacgaat aatcacatca tccgcttcta ttatttgcgg
    21181 acgttcaatg ctagcaagtc caacctgacc tgcctttgta tatactgctg atttcattta
    21241 aaattttcct tccttataaa gtttaatttt gagatttaaa cgatttaaag ctgtctgtag
    21301 ctgagacaag cgctcctcta atttttgctt ttcctcttct aaaataccaa gcctctcctc
    21361 tctcgtttca tctccctttt ggtagagcga catatagtca actaaactat ctacagagac
    21421 acccgccgaa cgaaaacact taataaattc cagcgcttcg atatcctgat cttgaaaatc
    21481 acgaatccca gtagcagtac gagtaatcgg tggcacaaga ccaacccgtt cataataccg
    21541 aatcgtatcc gctgaaattc ccaacaaatc actggcagat ttaatattca cacgctaacc
    21601 tcctctcatt tcattcactg aattcacgct attctaactc acttatctta ttatataact
    21661 ttgagttgac tccaagtcaa gcattttgta tctaatcgaa aaatttttat cattaacaat
    21721 catatatctg gagtttatac aatgctcttc tcttaccaat ttttgaaata tttaaataat
    21781 aaagaaatta ctctattcca aataagatag tacccaagta tttttcactt ttttctaatg
    21841 ttgatgctca taactccgtt ccaagtcaca cacctttcgc ttatgggttt ggtgagtttc
    21901 taggtcagca tcaatttcaa tggtaatatt ttgaaaacca caatctttta ggaaaattcg
    21961 aatagactct ttacaagttt ccatatgttc catttctttt agacaaacat gtacaatggc
    22021 atttttttcc aaagcatcca tagtccagag attaagctga ttaaggctgg ccacattgtc
    22081 caatcgctcc aggccactct ttacttgctt gatatcaaga ccttctggca cagcatccaa
    22141 gaaaatcttg agtgtagacc aaaaacgtgg aagggctttt gaaagaataa agaaagaaat
    22201 gacaagggac aaaagaggat ctaggatata ccagtccgta aatcgaagaa caatcgccat
    22261 caggataaca gctacccacc ctagcgtatc ttccagaaaa tgcaaactca gaatagactc
    22321 attctttgtc tttcccttac caaccaccag actcgctaac agattgatag taatcgcaat
    22381 aattcctaac cagagaatcc cctcatcatt gactggttgc ggatgcaaaa tcttcgtgac
    22441 attttccaaa atgactagaa cagagcccgt tacgagaatc acagctgtta ccaaggctcc
    22501 tagcaggcta aaccgcttat agcccaaggt gtactgattg tcttcttcac gattggagat
    22561 tgtttctaga aaagctgata ttccaattgc aatcgcatct cccaagtcat gcacagagtc
    22621 agcaagaaca gcgctagaac caaatactcc acctgcaata aactcaacaa tggcataagt
    22681 caaatttaag aaaaaagcca cccaaacagc atattttgcc ttcatatttc tcattccttt
    22741 gttataatag atttatgaac accttgttca ttatcattat ccactaaaac tcaaagaaag
    22801 gatagaagca aaacgtcagc tttattcagt tctgaacaat ttgccttaag tgtccatatg
    22861 actaacattg accgccgtat cagcaaaacc aaaaaagcca tctatcaagc ttttatacaa
    22921 cttttgaatg ctaagggcta cgaggccact actgttcagg atatcattga tctcgcagat
    22981 gtgggaagat ccacctttta ctgtcactat gaaagtaagg agcttcttct ggaccagctc
    23041 tgccgctacc tcttccatca tctttttgaa agagagcaag ccatttcaac cgaggactac
    23101 ctcgcccacc tctttctcca ttttcataaa aaccaagacc atatcaccag tctgctattt
    23161 tccaaaaatg actacttcct ccgtcaactc cataaagagc tagaacacca tgtctattcc
    23221 gtgctagctg ataatttaaa agaagcccac cctaatatgc ctacttctta cctccaacac
    23281 ttggtcgtgt ccaactttat cgagacattg acctggtggc tcaaaaaagg tcaagatttc
    23341 acaggccagg aagttgtcca attttatcta gaccttctca ttcctaaaaa ttgaatatag
    23401 agtaaagctc agttgtctta tttctaggtt actgagtttt ttatcttttc aacaacaaaa
    23461 gaggacccgc cgatcctctt tttcatacta taaatccttg attatcaact atatctgttt
    23521 taatcgaaat ctcaaaacag cactttcaaa catcttttcc tagttaagta aatcagtatt
    23581 ctgcttagct gccttgctcc attgatacca accaactaga ctgttaatga gataaattag
    23641 atatttccct tgaatttgca ggctttctcc ccaccagaga tagattgaaa aaacattggt
    23701 agccgcccag aatatccact gttcacggta aacagctgtc atgaggattt gccctacccc
    23761 attggttgca tctgtgattg aatcacgata gggacgattg gcaccaatag actgataaat
    23821 gaagccaaag gccaaccacc aaagcacact aatggaaaga tactttgtcc agcccttgcc
    23881 gtccagttta cgcgcgacaa actcctgctt ttccttctta aactgtgcct gataaatcca
    23941 aactagaagt ccaattggct gcatgactgt gaagtaaagt gtcgtcagca cctcaccata
    24001 aaagcctttc tgtagggcca aaataaggta aataacagag ttaatcaagc caaaaagata
    24061 attacttgct cgaccttccg atacaaagat tacacagata atccctgtca agctacaaat
    24121 catcccaatc cagtcaacaa tacgatgttc gtaaaccaac tccagccaga gaggaaaact
    24181 tcctaaaacc agcaaataaa tccactgggc aaaactacga tgggcaaaga ggtcatccca
    24241 gatagccttc atagttcctg aaaatcctaa atcagccata gccgcaacca tacgacggta
    24301 accacctgac atttcaccta gggttgtttt gatattttca attttctttt gcaaataagt
    24361 atgcatcatt tctccttttg tttttaaaga gccgtgtctg gatagacttt cggacgcaac
    24421 gctctattag ataatgaact gcctatacac aagatttcta accttagtcg acatgagcta
    24481 aaacctctta tttgttaagt agttcacaaa atattataca cctattttat gaatagtcaa
    24541 ctgtctttac agtaaaattt tagaaaatca tgaaaatttt ctctttcttt ccattttaag
    24601 tgacattcag tcattctcac atcaaaaaag cccagacgaa attgtctgag cattctttta
    24661 tctagtcgtt taaggaagtt gagttcagta tgtttaaagt ctctgtccca tcatttcttc
    24721 aacaaacctt gttcttggag aaactccttg gctacttgct ttgctgactt gccttcaaca
    24781 ccgacttggt agttgagctg gctcatctgg ctttctgtaa tcttaccagc caatgtatta
    24841 agaactcttt ccaactctgg gtgtttcttg agaagagctt ctttcatgag tggagcccct
    24901 tgataaggtg ggaagagttg cttgtcatct tccaagacct gtaaatcata acgctccaat
    24961 tccgcatcag tcgaataggc atccgtgatt tgaatatccc ctgactgaat tgcctgataa
    25021 cgaagagctg gctgcatagt cgccacattg agattgagac catacattga ttgcaagccc
    25081 ttatttccat cttcacggtc gttaaactca agcgtaaagc ctgccttcag ctgcccttcc
    25141 acttttttca aatccgaaat ggtcttcaag ccatattctt gagcaatctt tttcggaaca
    25201 gctacagcat aggtattttg ataagacata ggtttgagat aggctagatg atcctgcttg
    25261 gcaatgccat cacgcgccac ttgataaacc tgctctggct catgactcac cttgggtgat
    25321 ggttgaagca aactttcagt caccgtaccg gtaaattcag gataaatgtc aatatcacct
    25381 tttttcagag cttcataaag gaaacttgtc gtcccaaaat tcggtttaac agtcgcagtc
    25441 atgctggtat tttcttcaat cagcaactta tacatattag ccaaaatttc tggttctggg
    25501 cctattttcc cagcaataat caagttttcc ttctcttttt gagccaaaag agctggacta
    25561 taagacagac ccagtaataa agccaccaag gcaaaaccag agaaaatcgt ccgcaatttc
    25621 gctttttcca ttacttttag taggaagtta aaggcaatag ctagcactgc agaagaaagg
    25681 gccccaatca aaatcaaact ggcattatta cggtcaattc ccaacaggat aaaggaaccc
    25741 agtccccctg ccccaatcaa ggtcgccaag gtagccgtac cgataatcaa gaccgctgcc
    25801 gtccgaattc cagacatgat aacaggcatg gcaagtggaa tttcaaactt cttgagacgc
    25861 tcccatctgg tcatcccaaa ggcaatccca gcctcttgaa gactcggatc aattcccttc
    25921 agcccagtaa tagtattttg taaaatcgga aaaatcgcat aaatcactag agctgtcaaa
    25981 gccggcaagg tcccaattcc catcaaaggg ataaagagcc ccaacaaggc cagagacggg
    26041 atggtctgga aaatacctgc aatctgcaag acccagtcgg ccagcttctc atgatagcga
    26101 agaaaaacag ccaagggaat cgcaagcaaa atagctagta acaaggtcaa aagtgacaac
    26161 tgcaaatgtt gagatagagc tgtcaaccaa tcactaaaac gatcctgaaa agttgcaatt
    26221 aaattagtca tgaacactac ctccaaacaa gtctgctaca aagtctgttg caggcacttt
    26281 taaaattgtc tcgggattcg ctacctggcg aatttctcca tcctgcaaga cagcaatacg
    26341 gtccgccaac ttcaaggctt catccgtatc atgggttaca aaaatcgttg tcatcccaaa
    26401 ctctttatgc aattcttttg tcagaacctg caactgtttt ctcgaaatag catccaaggc
    26461 cgaaaagggt tcatccatga ggaaaatctt gggctgacca atcatagctc ggacaatacc
    26521 gacccgttgc tgttctccac cagataattc actaggtaag cgatgcccat actcggctac
    26581 tggtaaacca accttagcca aaagctcttc tgttttcttc gtaatttctt ccttgctcca
    26641 ccccttcatt tcaggaatga gagcaatatt ttccgcaact gttagatttg gaaaaagagc
    26701 aatagcctgt aaaacataac cagtagaaag acgaagttca cgctcatcat agtctttgat
    26761 gcgcttccca tccatataaa tatttccatc agttggttcc aaaagacggt taatcatctt
    26821 gagcatggtc gtcttacctg acccagaagg ccctactaaa accataaatt ccccatcctc
    26881 aatctgtaag ttgacatctc tcaagacatc cttttctgtg tagcgcagtg ctacattttt
    26941 gtattcaatc attctttgtc ctcaatttaa aacttccctc gattagtcaa gtcttctacc
    27001 ttaggcatga cttccttatt atcccaatgc tccacaattt tcccgttctc taaacggaag
    27061 atatcgtact gggcataagc aacgccatca atctgagtct gaccatagct aaccacatag
    27121 tttccttgtc ctaagagttg gaaaacaaag tcaaaagtga cactatattc agccacatag
    27181 tttttataag cagcacttcc ttgtccaatc tcatgattat gctgaatcaa atcgtctgcc
    27241 acataatcac tccactgctc tagctcccca ttttggaaag tttctgtcaa gaaacggcga
    27301 accagctttt tattttctgc tttcttgtcc aaatccttga tttcaaaatc tccaaaaatt
    27361 tgatctagtt ggtcattttc aggtgttcga tagtagtcaa tgacatccca atgctcaaca
    27421 atacgaccat tctcatccgc acggaaagta tccgtcgtca cccattgagc ttctccacca
    27481 ttcagatatt gatgaacatg aacaaagacc agattgccat cctcaatggt gcggacaatc
    27541 ttaatctgac gctctggatg acgctcaaag aaatctgcaa agaaggctgc aaatccttct
    27601 ttcccgtcag gaacacctgt cgaatgttgg atataggtat cccctacaga ctgggcttga
    27661 gcctcagcaa ctcgtccgtc ttgaatggca tggatgtata ggttgtgagc atttttcact
    27721 tgttgtgaca tattctaaac ctcattttcc ttctctttca gatttgccaa aattctttct
    27781 tgaaaacctt caaattggtg aatttcttcc tctgaaaatc ctttgtaaaa gatagtatcc
    27841 aatttctgac tgacacgatg ccccacttct ttctggaact tgcctaactc cgttaaaact
    27901 aaatacttct tacgcttgtc ttttccacac ggactaacaa ttacaagctt ttgttcctct
    27961 agctttttta tcatagtcgt cagcgtatta ttcgcaagcc cagtcgcaag cgcgatatct
    28021 gtcgcagttg cgcagccagt ttcactattc cataaaaccg ctaaaatctt gccctgttca
    28081 cccctataaa gagcctcagg atcttgactc agtaactttt gaaaaatccg cccattcaac
    28141 aaacgaatat gatgggctag caaatgacta tctttcataa cacctccaat ttatttcgat
    28201 atcgaaatga ataaaataat tgtaacactc atcgttctaa ctgtcaacta tttcgatttg
    28261 gaaataattt ttgataatta ttcacaccac catactccgg ctcaactaac ttttaacgag
    28321 agtttctaaa ttccttcgtc ctccagtcta caaaagcctt ccatccgtac tatcctattt
    28381 tttatgaggg gacacatttt tcctatcaga tcatttattt taaagataga agtaaatcat
    28441 aattgcttcc atctgttctt ttatagtata ttgaagttgg actagggcac tgtatcttct
    28501 aaaacattga tagaaagcga tttgaatttc ccaatcaatt tgttcgtatt tatagcattt
    28561 tgaaactaga ataggacgcc atgactgcta aaagatttct ataaattcat ttgatttccc
    28621 taatcaattt gttcatatct tatttcattc cgctataatt tcaccttacc ctatcttttt
    28681 cgtagcaccc ttcaaacagc ctatccccta ccgtttgatg attcctcact tcactccact
    28741 tccattacag aagtttcttc actactatgg tctcggctga cttctcatga ttccttgtta
    28801 ctactatttg aacgctcacg agataggtct tataaaaaat gctttgatcc acaatggaat
    28861 caaagcattt taaaaagttc ctcatacata agcgcagaag tcgcagttcc tctgtacttg
    28921 gcttcttctc ttttgacaaa gcgagccaag ttgagcaact caggtgctgg atgtttggga
    28981 tttaggagca attcacgatt gaccaggctt gagagacgaa ctgcctgcaa ttgctcattt
    29041 gtagtaggca gttttttagt agtctctagg agagcagcaa ctaaatcttc actcaaatca
    29101 tgtcgagcat gattgtaaag atcttttata aggctttcta ggtttggttc taccatccct
    29161 accacctccc ttatggttta ataatgttta atcaaatcaa ccgttgaacg atccaatttc
    29221 ttcaccaagg cttgtaagaa agcttgcgct tctaggaagt catccattgc atagagggtt
    29281 tggtgagaat ggatataacg agcgcagaca ccgatagttg ttgatgggac accaccattt
    29341 ttcagatgag ctgcacctgc atctgttccg cctttaccac agtagtattg gtacttgata
    29401 ccagcttctt cagccgttgt caaaaggaaa tccttcatcc ctgggagaag caagtgacct
    29461 ggatcataga aacgaatcaa ggttccatct ccaatcttgc cttgaccacc gtagacatca
    29521 cctgctggtg agcaatcaac tgcgaggaag acttctgggt caaacttggt tgtagaggta
    29581 tgagcgccac gcagaccaac ttcttcttgg acgttagaac ccagatagag ttcattgccg
    29641 agtttttgac ctgataaagc ttcagctagc tcgcttacca tgaggacacc gtagcggtta
    29701 tcccaagctt ttgagatgat atttttttca ttggctgtca aaattgcaga actatctggt
    29761 acgatggtat caccaggacg gatgccaaaa ctttctgcct cagccttgtc cgcaaaacca
    29821 ccatcaaaaa cgatatcggc aatggctggc atggttggtc ccccctttcc acgagtcaaa
    29881 tgcggaggaa cagaacctga aatcacagga atttcatgac catcacgagt caagagtttg
    29941 aaacgttggc tgctaaccac catggggttc cagccaccga tttctacgac acggaaggta
    30001 ccatctggct tgatttcgct gaccataaaa ccaacttcgt ccatatgaga agcgaccaag
    30061 acgcgcggtg catccacagc ttctgaatgt ttgataccaa aaataccacc caagccatct
    30121 gtcaccactt catccacatg cggtgtcaac ttttcacgaa gataagcacg gacaggcgct
    30181 tcatgacctg agactgcagc aagttctgtt acttctttaa tttttgaaaa taatgttgtc
    30241 atttcagttc cttctttctt tcatccattt taccactttt tataggagaa ggatagtggg
    30301 aaggtggatt tctaagttag tatcttagtc ctgctctatc ttagaaaagg atagtattct
    30361 cttgcatgta gtgcaaaatc tagtaaacat tccaaaatta actcgaatat ttatttccaa
    30421 acaaaaaaac aatacaccat caaagttgtt tggatttttc atgaaattta cagaaaatag
    30481 ttgacttccc tttcttcttt ctttaaatat atagttggtt gagtttggaa tagtacgctg
    30541 tagctgctga aacatttcta gaaattaatt tgactttcct aatagagttg ttcatatctt
    30601 atttcaattt actatagtac aaaactagaa aaggaaaaaa tcatgaccaa aacaattctt
    30661 gttacaggtg ggactagcta cattggctcc cataccgtta aagctctttt aaatgctggc
    30721 tataaggtgc atgtcctcga taatctctcc acaggaaatc gagcggctgt ggatagtcgt
    30781 gctagcttta aagaactgga tatttatgat gctagcgcct taaaggctta cttagaagaa
    30841 aatcagattg atgctgtcct ccattgtgca ggtgaaattg ttgtgagcga aagtattgaa
    30901 aatccaagta aatacttcac tgccaacgtt gctggtatga accaagttct caaagtctta
    30961 tctgaagttg gcattcaaaa aatcatgttc tcttcgactg cttctctcta tggaaataac
    31021 tgtattgaca agccggtgac tgaagatacc ctgctcgacc ctgtcaaccc ttatgcagag
    31081 acaaaactga tgggcgaacg aatgatttac tggatggcca atcgctacga ctggaaatat
    31141 gttattttcc gttactttaa tgttgctggg gctgaaatgg atgcttcaaa cggtctgcgt
    31201 gtgaaaaatc caactcacat cattccaaat atcaacaaga ccgcattggg acaaaatgat
    31261 agcttaaaaa tatttggaga tgactacgat acacgtgacg gttcatgtat tcgagattac
    31321 atttatgtct tggaccttgc ataggctcat gttaaaggaa tgaactacct atttcaagaa
    31381 gacagttctt ctcaaatctt taacttagga actaaaaaag gctatactat caaagaaatc
    31441 tttaaaactg ctgaagaatt actaaattaa aaaatcccac acgagattgt tgctcgacgt
    31501 gctagtgacc cagccagtgt cctagcagat gcttcaaaag ctaaacaata tcttgattgg
    31561 acggctagct actccctcga agatattatt ttatcagatt aaggtaaaaa cattttagaa
    31621 taggataaca aaggagaaag tcttgttgct ctctccttgt tgtatttatt aaattgtcag
    31681 aaattttatt gacagattag aaaaataatg ttacatttat atccgcaggt atctttcgat
    31741 accaaatcta catgaaagga cggggtatga aactttctca ttatttaatt ggcttacttc
    31801 tactcctagt ctttctctct attagcattg ggaccagtga tttttcatgg ggaaagctat
    31861 ttgatttcga ccagcagacc tggctcctct ttcaagagtc ccgtctccca agaactatca
    31921 gtattctcct gactgcctct agtatgagta tggcaggcct tctcatgcag actattaccc
    31981 aaaatcagtt tgctgcaccg agtacagttg gaacgactga agccgccaaa ctgggaatgg
    32041 tgctgagcct ttttgtcttt ccatcggcta gtctgaccca aaagatgctc ttcgcttttg
    32101 tttcatccat cctattcacc ctcttcttcc tagcctttat gaccattttt actgtaaagg
    32161 aaaggtggat gttgcctctg attgggatca tctatagcgg gattatcggc tcagtcacag
    32221 aagttatcgc ctatcgtttc aatctggttc agagtatgac tgcctggacc cagggctcct
    32281 tctccatgat tcagacccat cagtatgagt ggctcttctt aggcctcatc atcctgataa
    32341 ccgtttggaa attatcccaa accttcacca tcatgaatct agggaaagaa accagcgaga
    32401 gtttggggat ttcctactcc ctacttgaaa aactggccct ctttctggtg gcgctaacga
    32461 caagcgtcac catgattacc gtgggtggct taccatttct cggagttatc gttcccaatc
    32521 ttgttcgcaa gcgctatgga gataatctaa gtcaaaccaa actcatggtc gcactggttg
    32581 gtgccaatct agttctggct tgcgatatcc tatcccgagt tctgattagg ccctatgagt
    32641 tgtctgtcag tctcttgcta ggaatcatcg gtagtctcgt ctttatccta cttctctgga
    32701 gagggggacg aaaagatgca aactaaaagc aaacatacca agctcttctg gattctcatt
    32761 attcttgcca tcggagcttg tcttctctac ttttggccca tcactcactt gtcagccttt
    32821 gcttggaagt tgcgttccca aaagatcatc gtttatctct tggtagccat cgcgactggg
    32881 atttcgacca ttagttttca aaccctgacg gaaaatcgct tcctgacgcc tagtattttg
    32941 ggaattgaat ccttctacgt cctactacaa accctactac tggtttttga aagcaagttt
    33001 cttcaacttg gcaaatcccc tatcttagaa ttcctagtct tacttcttgt ccagtccctc
    33061 ttctttctcg ccttacaagg ttacttgaag acactgatga agcaagacct ggtcttcatc
    33121 ctgctgatct gtctagcgct cagaagtctc tttcgaaata tcagcacctt ccttcaagtc
    33181 ctaatggatc caaacgaata cgataaactg caaaatagtc tttttgcctc ctttcaacat
    33241 cttaacactt ccatcctagc catcggttct ctgatcatcc tcgctttgac aatctttttc
    33301 tttcgaaaag cagtcgttct agatgtcttg cacctgcaaa gagaaacggc tcagatattg
    33361 ggactcgatg ttgaaaaaga acagaaagag ctcctctggg gaatcgtgct tttgacctca
    33421 acggccactg ccttggtagg acctatggcc ttcttcggct ttatgctggc caacctcacc
    33481 tacctgattg tcaaagacta tcagcacaag ttactcttta tagtggccat tctggttgga
    33541 tttattagct taaccttggg gcaagccttg attgaacgag tctttgcact ggaaattcgt
    33601 atcagtatga tcattgagag tgtgggtggc ttcttattct ttatcttact atataggagg
    33661 gctcgtcagt gaaactggaa aacattgaca aatccattca aaaacaggat attttgcaag
    33721 gcatttcgct tgaagtcagt cctcaaaaac tgacagcctt tattggtcca aatggtgctg
    33781 gaaaatcgac tctcctctcc atcatgagca gactaaccaa gaaagatcag ggagttctca
    33841 gtatcaaagg acgtgaaatc gagagctgga attcgcaaga actggcccaa gaactaacca
    33901 tcctaaaaca gaaaatcaat taccaagcca aattgactgt tgaagaactg gtcagttttg
    33961 gacgttttcc ctacagccga ggtcgactta gatcagaaga ctgggaaaaa atccgagaaa
    34021 ctctgaacta tttggaactg accaacttaa aagaccgcta catcaatagc ctgtcagggg
    34081 ggcaactcca gcgcgtcttt atcgctatgg tactggccca ggatacggac tttatcttgc
    34141 tggacgaacc actcaacaat ctcgatatca agcaaagcgt cagcatgatg cagattcttc
    34201 gacgactggt ggaggaactc ggcaagacca ttatcatcgt cctccacgat atcaacatgg
    34261 ccagtcagta tgcagatgaa attgtcgcct tcaaggacgg ccaggtcttt agcaagggaa
    34321 gaaccgatca aatcatgcag gctgacctgc tcagtcaact ttatgagatt cccatcacgc
    34381 tagctgatat caatgacaaa aagatctgta tctatagcta gtaacataaa agctcaagtt
    34441 agagaacctt cagtctctta gtcaataaga ttaagagact ccctaaatcg ttatcacatt
    34501 ttaaaaagga gaaattatga aaacatccct taaactttat ttcactgccc tagtggccag
    34561 cttcttgctc ctacttggtg catgtagtac aaactcaagc actagtcaga cagagaccag
    34621 tagctctgct ccaacagagg taaccattaa aagttcactg gacgaggtca aactttccaa
    34681 agttcctgaa aagattgtga cctttgacct cggcgctgcg gatactattc gcgctttagg
    34741 atttgaaaaa aatatcgtcg gaatgcctac aaaaactgtt ccgacttatc taaaagacct
    34801 agtgggaact gtcaaaaatg ttggttctat gaaagaacct gatttagaag ctatcgccgc
    34861 ccttgagcct gatttgatta tcgcttcacc acgtacacaa aaattcgtag acaaattcaa
    34921 agaaatcgcc ccaaccgttc tcttccaagc aagcaaggac gactactgga cttctaccaa
    34981 ggctaatatc gaatccttag caagtgcctt cggcgaaact ggtacacaga aagccaagga
    35041 agaattggcc aagctagaca agagcatcca aaaagtcgct actaaaaatg aaagctctga
    35101 caaaaaggcc cttgcgatcc tccttaatga aggaaaaatg gcagcctttg gtgccaaatc
    35161 tcgtttctct ttcttgtacc aaaccttgaa attcaaacca actgatacaa catttgaaga
    35221 ctcacgccac ggacaagaag tcagctttga aagtgtcaaa gaaatcaacc ctgacatcct
    35281 ctttgtcatc aaccgtaccc ttgccatcgg tggggacaac tctagcaacg acggtgtcct
    35341 agaaaatgcc cttatcgctg aaacacctgc tgctaaaaat ggtaagatta tccaactaac
    35401 accagacctc tggtatctaa gcggaggcgg acttgaatca acaaaactca tgattgaaga
    35461 catacaaaaa gctttgaaat aagccacttc aaactcaatt taatactcaa tgaaaatcaa
    35521 agagcaaact aggaaactag ccgcaggttg ctcaaaacac tgttttgagg ttgcagatga
    35581 aagctgacgc ggtttgaagg gattttcgaa gagtataaaa ttttgacatt ctaaaacgca
    35641 tcctatcaag ttcactcaaa cctgatagga tgcgttttta tcattttgaa atctatttac
    35701 cccacctcat tccccttctt gatttcgttt aagggaaaag tggtctggaa cggggtcctt
    35761 acctgttttc gaccagggat gacaacgtaa aatccgagcc aagcccatca ataccccctt
    35821 aaaaccatgt ttttcaatag cctgaatcat gtagttggaa caagtcagct caaagcgaca
    35881 agagggtgga aagactggtg agataaaacg ttggtaaaag cgcacaggcg ctattaaaat
    35941 tcgtttcatt atttcttagt tacagccatg gtgtgtagtt ggctgatttc ttttttatta
    36001 agacgacggg attctcctgg acggagtcct gtcaagtcta ggtgtccgaa acgagtccga
    36061 gacaacttat ctacttggag accaacagct tcaaacatct ttttaacctg atggttacgc
    36121 ccttcatgga tggtcaactg caccacagag cgatttttga ctgggtccac tttgagaatt
    36181 tcataaacag ctggcttggt tttcttacca tcaatctcaa gaccacgggt caaggggcgg
    36241 agattgtcct tattggccac acctttaaca cgcgcgacat aaaccttgtc aatctcatta
    36301 cgagggtgaa tcatctcgtc tgtaaagtcc ccatcattgg tcaaaatcaa gacacctgat
    36361 gtatcccagt ccaaacgacc cacagggtaa atacgttctt tgacattggg caagaggtcg
    36421 acaaccgtct tgcgaccctt atcatctgtc acactggaaa tcacaccgcg tggtttgtta
    36481 agcagatagt agaccttttc ttcgttgtag ataggttgac cttcaacttc gaccttgtcg
    36541 cctgacttga tagtggttgc tagttcacgc accacttggc cgttaaccgt caccaagcct
    36601 tgcttaatca gctcttctgc ttttctccta ctggccacac ctgcgtgggc aatatactta
    36661 ttgattctca tcttcttcta tcctttcacc aaataattgg ctttcttggg cttgaatctc
    36721 aagctcatca atcactggta attcttctaa atggtttatc cccatgtaat ctaggaaata
    36781 atccgtagtc acatagaggt tggggcgccc caatacttcc tttttcccgt cttcctttat
    36841 caggtcaaaa gcctgcaact ttgccaaggc tccactcgag ttaaccccac ggatggcatc
    36901 aatttctatc cgcgtaatcg gctgtttgta ggcaataatg gacaaggtct caagggcagc
    36961 ccgagacaag ctctggttga taggcgcctt agagtattcc ttcaaaatct ctgcaaattg
    37021 aggcttggtc accaatctat aagcaccact tgtctcaatc aaagccaaac tggaatctgg
    37081 gtccttttca tacttctggg ctaattttcc taaactttgc tggatgcctg tcggtggcag
    37141 agagaggagt tcagctaact ggcggacccg aatcccatct tcacccgcta caaacaagag
    37201 cgcttctatt tttgctaaag tactcatctt tcctctctat caagtctagc tttgaggcac
    37261 ttgactttct tccttctttt ccatgagata gatatctcca aaactctcct cttgcacgag
    37321 gatcagctcc tgggttttga ttaactctag ggttgccaaa aagagggtga tgacctcttg
    37381 gacattctgg gcttccttga acaaatcctg caagcgcaat tgatctcgtc caatcaagga
    37441 ctctttcacg ataatcatca tgtcctcaat cttatactca tcccgcaaga tcgtcgtatg
    37501 attttgtgca aactcctctt ttttcttggc taggatattt gaaaaagcca aaaagaggtc
    37561 aatggtcgtc ttgtcatgca caagctccgc atcttcgtaa atcaactctg tcggcgcttt
    37621 ggaataatac tgggcccgtt cttggtgctt ggcttccaag tgctcaccca agagcttgaa
    37681 cttgcgatat tcttcgattt gagagaggag gtcctgctcc aggtcatccc ccaagtctgt
    37741 cacttctgct accttcggaa ggagtttacg actcttaatc agcatgagct gactagccat
    37801 gaccatgtac tcacccgtca cttccagacg catggcctgc agggttgaga cataggctag
    37861 atactgttcg atgacttccg taatgggcac atcgtagata tccatctggt acttagaaac
    37921 cagatgcaag agcaagtcca ggggtccttc aaaatctttt aatttaatat ccattatcta
    37981 tatttttcta aggtcaggac tgtttttaat cctaattttt ttgcaatttc gtacaaatcg
    38041 accttgtttt ctatttgtct tagaataaac tgttcacgta agacttgagc tgataaggat
    38101 ggaaaacctt tctccttgac aaaagattct aactgacgaa aggcccactg acgagaatag
    38161 ggtttctctc ctctttcaaa aagataggtc tgccccatca agggttccaa ttctgaaagc
    38221 aaggccgtgg gaatagtgac aatcctctgt tgggaagcct tgctgattcg caacacctga
    38281 aaatccagat tgatgtccgc aaccttgatg gctaaaatct cactgggcaa aagccccatt
    38341 tctaggatta agagcgctag caagcggccc tctggatggt cgctttcctg ccaaaaagag
    38401 tctaggtata gaatctctgg cttttccgtc ttcttttcag cttgtttggc taattccaag
    38461 cggtaaaagc tgtccacctc tcctttttga tagagaaagt atagaaattg gttacaggcc
    38521 gaaatctttc gcttctgggc gctgattttt agattggcta gctgggcttg gtaaatcttg
    38581 agactggtct cagaaatccg ctcacctacc atgtctaaaa attgctccaa atcatactta
    38641 taggactgct tggaattgac agacaagccc tgcttttcct ctaaaaaggc tgaaatcctg
    38701 tctctcattg gcatcgaatc tcatattcct tactaaagtc atgcaagagg gcattaacgg
    38761 ccttgaggat ggacttgcgc gtaataatcc cttggaaaat accctctgca tccacaaccg
    38821 gtaagaagga ctcatctact agcttgtgca agacctccgt aatggtgaaa tcaggcgaaa
    38881 caaccgctac gtccgttttt gtcatatgaa cgatatccgt atccgccatg atttcttggc
    38941 tcaagtcatg ctccatctga taagccataa tatctctgag tccaatcgtc ccaacaaact
    39001 gtttttcatc tgtcacaacg ggaacacggg tataggtcat ctgactgagc aagagggtcg
    39061 catgatccgc attgtgggta tcaatcaaca cagctagatt tttagcaggg gtcaaaaaag
    39121 tttcctcctg ccccaacaag aaagtctcaa actccttggc aatcatcggc taaactcctt
    39181 ggacaaacct ggatacacct cgtgatctcg tgtcaaaaag tccactttga agtaactatc
    39241 atcaatctcc acacgagcat agagacattc tctgatggta cctcgtggtt gactgataga
    39301 acctggattt agaaagagga tcttgccttc caaccaagca cttggcacat gcaagtgacc
    39361 atagaggcag atagcggcct cttcctcctg agcccagtag tccaactttt gaaagttgaa
    39421 attgatgtca aacaagtgac catgagtttg gataatcttg gtcgaaccaa gctcagtcac
    39481 cagacgttct gggtagccgg cgtagaagtc catgttccct ttaacaacgc ggatgccctc
    39541 ccaaagtgga gaatccggac gtagttcaga atcgccgtta tgaaaaacgg catcgacttt
    39601 gcccacatag cgatcacgga cttcttccac aatcaagcta tcgccatggg aatcgctcat
    39661 tacaatgatg gtttgctttg ccatgatgga aatacctcca aaagtttctt aacggctaag
    39721 gcacggtgag attgactatt tttttcttcc agggttaatt cagctgatga ctcacctgtc
    39781 tctcctacaa ggaagagggg atcatagcca aagccatttt cacccttagg ttcaaagtta
    39841 atataacctg accagtctgc ttcaacaact aaactttcct tatttgggct ggctacgact
    39901 agggttgtgt ggaactgagc cgagcggtcc ttgagttcaa agaccatggc caattcgtgc
    39961 aagagtttgg cattattttc acggtcagtt gctcccacac ctgcgaaacg agctgaccag
    40021 acgcctggta agccaccaag gacatcgact ttgagaccag aatcatctgc caaaaccatc
    40081 ttgcccgtta attgagaaat ggtttctgcc ttaaggcggg cattttcttc aaaggtcata
    40141 cctgtttctg ctacttcagg caggtcaggg tagtcattaa gattttccac atcgtagcct
    40201 aacttatcaa agatagctcg gaattccttg gttttacctt cgttacgagt cgcaatcaac
    40261 aaggtttctc tgaccttgct tgtctcaaag aaatcatgaa cattgacccc ttctttaggc
    40321 aattctacat acaagagttg cccattttca accaagagca gggccccatg acgttgaata
    40381 acttccaagt ttcgtcccat ttcttgatta agcatgtcta ccacaaagga gaacaaacgg
    40441 taggtagaac catagcgtaa aacagtaact gaaagcggga aaccatactc ttcatctcca
    40501 aatattttgg agaattcaaa cagaggaaaa tctgtcttat agtcgctcaa actgttaacg
    40561 ccaccaaaaa tactataaga cccaacatac cagtcctggt catccttata ttcataaatt
    40621 ttatttgtca taattctaca tgctccacat gaatctcttt ttccagccat tcttcaccaa
    40681 tttgtgcaaa actttggcta ctggctgttg tgtaaaaacg gtgatggagt ggtccagcat
    40741 cgcgaccacg attgatttca aaataattga gtaagactga gatatcccgt acgcactctg
    40801 ccccactatc gatgagctga acctttggcc ccatcacatt ttggataata gggcgaagga
    40861 gtggataatg agtacagccc aaaatcaggc tatccacctt tccaaccaag ggacgcaggg
    40921 tttcatagac caccttcttg gtaacactgg ttgacagggc acctgactca accaagggag
    40981 caaacttggg acaggccaag ctctccacct gtaagtcggg atccagatca tggattttct
    41041 gacggtatat gtctgattgt accgtcatgg gcgttccaat cactccgatt ttcccacctt
    41101 gactggactt gatggctgcc gaagctcctg gcaaaattac acccaagaca ggaatatcta
    41161 gttgagcctt gatttcttcc cagacgaccg cagtcgcagt gttacaagca atgacaatca
    41221 ttttgacatc cttggtcaag agaaagttga ccagctgcca agtatattca cgaatttgct
    41281 cagcaggacg ggggccatag ggcgcccgcg ccgaatctcc aatatagacg atttcttcat
    41341 ggggaagctg gcgcatgagc tcgcgcacaa cggtcaagcc cccgacaccc gaatccaaaa
    41401 aaccaattgg tcgattatcc atacagtctt ctttctagtc ttttttctga ttgatcgttc
    41461 attatgattc cttgtactga acgaactgac cgacagcttg atagaatgtc aactacctct
    41521 ctcttaatca taatcaaata tcaatagaat gcaaggaaaa agtctcatcc ctaaaccata
    41581 accaacatag tgagaagtct ggaactttca tcccagactt ttccttattt attttttctt
    41641 tttattgtta gcaagggctg ccttttgttg gcggatgatt tggtggtaaa cttgttgtac
    41701 cttagcttcg cttggttttt gaccatttgc actcaaaaga gtacgaactg cttcagcatt
    41761 caaacgtggg ttgtcagcaa attctttttc gatttgctta cgaaccaagt acattcctcc
    41821 aagagctcct cctagaaaag ctagcacaat caatacaatt gctaaaagta aatccatcat
    41881 ttttctcctg tttctttttg aatccctttc attataccac aaactagcca ccctgaccag
    41941 tttgttctac actttcaagg atggaataga cagcaaaaag aaccctgctt ttctgaaaaa
    42001 gaggtctcct tgctaagttt aatttacata aatagccagt gtttgatagg gttttagtag
    42061 aattttctca gacacttctg catcttcata gtttgaaatc aaaatctgtc cattttggta
    42121 gactgctggc aagtcgattt ccacttcttt agcataaaag ttattgagca ctagtaactt
    42181 ttgatcctca aactggcgtt caaaagcgta gacttgtttg ctatcttcaa aggctggttt
    42241 gtaacttcct tctgaaatga ttggcatttc cttacgcagt cgaatcaagt cttgatagaa
    42301 ggtaaaaatc ggaccctgga tttcattttc tacattgatg tctttatagg atttaccagc
    42361 tttcaaccaa ggagtgcctg ttgaaaatcc tgcattttcc gaagcatccc actgcatggg
    42421 aatgcgtgaa ttatcacgcg acttagcttg aataatctgg aaggcttctt gctgactctt
    42481 tccttcttct aggagcatct gataggcatt aagcgattcg acatccacgt aatcagccat
    42541 agaatcatag tctgggtcaa tcatcccgat ttcctcaccc atgtagatat aaggtgtccc
    42601 acgtgacagg tgaatgctgg ctgctagcat agtggctcct tccttgcgga agttttgaat
    42661 atcgacaaaa cggttcaagg cacgtggttg atcgtgattg ttccaaaaga gggcactcca
    42721 accgtcttta tcactcattt ccttacccca actatggtaa agactcttca actcttcaaa
    42781 atcaaaggga gccaaggtcc acttttgtcc atccttatag tccaccttga ggtgatgaaa
    42841 attaaaggtc atggataatt cctgacgatc aggcgacgaa tagaggacac agttttccat
    42901 ggtggtagaa gacatttccc caactgtcat aaagctatcg tcagatccaa aagtggcttg
    42961 gttcatcata cgcaaatagt tatgaacgat gggtttgtct gtataagctg gcttcccttc
    43021 attttcagga cagtccactg aaacctcgtc cttaccgatc aaattgatca catcaaatcg
    43081 aaaacctttg acacccttgt cgcgccagaa attaacaacc ttgaaaagct ccttacggac
    43141 attggaattg cgccagttaa ggtcagcctg ggtctcatca aataggtgaa gatagtattt
    43201 cccagtatcc ccgaaaggcg cccatgcaga accaccaaac ttagactgcc aatctgttgg
    43261 ttggtcttgg atgaagaaaa agtcttgata atacttatca ccagctaggg ctttctgaaa
    43321 ccattcatgc tctgtcgaac aatgattaag taccatgtcc agcataaagt caatcttgtg
    43381 ctctttaccg acacacacca tttcctcaaa atcagccata tcaccaaaaa gaggatccac
    43441 tgccatataa tctgaaatat cgtaaccatt atcccgttga gggcttggat agaatggatt
    43501 gagccagacc atatccacac ctaatttggc taaataggga attttttcga taatcccacg
    43561 gaaatcccca ataccgtttt cagtggtgtc tttgtaagat tttggataga tttgatagac
    43621 tacttttcct ttatcaagtg tcatctgttt ctccttttct gataaaaggg aggaagcagt
    43681 cttccgtccc tatttgtgct atttcaatta tactcaatga aaatcaaaga acaaactagg
    43741 aagctagcca caggttgctc aaaacactat tttgaggttg cagatagagc tgacgtggtt
    43801 tgaagagatt ttcgaagagt attagattcg tgtagcgacc atgagagatg ctccagcttg
    43861 gatcgttgtc ggataagttc cgggaatagt cgctgtataa gcatcttggt tggtgatgat
    43921 aacaggagtt tctgtcacca gacctgcagc cttaatgaca tccatatcaa aacgaatcag
    43981 ttgctgacca actgtaacgt gatctccttg gactacaaga ctttcaaaac ctttgccatc
    44041 aagacctact gtatccatac cgatgtggat gagcaattca actccctcgt cagagacaat
    44101 gccgatggca tgcttggtag ggaaaagaac cgtcactgtc ccattaactg gagaggtcaa
    44161 ctcaccttgg cttggttcaa tgaccagacc ttgccccatg acacctgatg caaaaatagg
    44221 atccgtcgct tgactcaatt ctttcacttg gccagttagt gggctgataa tttctaccga
    44281 agtaagttct actggttcat ggttcacaaa ttctgcttct tcttgagcaa cgaattctgc
    44341 ctgcaagttc gtatcgccct ctgtttttgt aaagagacca gccttgcgga agaagaaagt
    44401 caagagcatt ggaacaacaa tcgcaactag catagttcct gcaaatggca gcatgtattg
    44461 aggttgaata gagagaatac ctggcaaacc accgatacca atagaagccg cagttacatt
    44521 aaaagtaacg gataacatgc ctgcaagggc tgaaccagtc atcccagcaa caaatggata
    44581 aatatatttt acgttaaccc caaaaagagc tggttctgta acaccgagat aggctgaaat
    44641 ggttgcagga agtgaaacct gagcctcacg ctcatcatgg cgatgcatga aataataggc
    44701 aaacacggct gagccttgag caatattaga aagagcaatc attggccata gggcagtgcc
    44761 accagcatcc gcaatcaatt gtgtatcaat ggcattggtc atatggtgca gacctgtgat
    44821 gacaaatgga gcgtagaggg caccaaaaat tgcaccgaag agccatttaa ctggaccagt
    44881 taaacctgcc aagacaactg atgaaagtcc ttgtccaatt gtccaaccga ttggtcccaa
    44941 aacagtatga gccaaaatca aggctggaat caatgacaag aaaggtacaa aaatcataga
    45001 aatgacttct gggatatgct tgcgccagaa gatttcaaga taagacagac tcaaacctgc
    45061 aagcaaggct gggataactt gggcttggta accgatacga ttaacagtaa aatagccaaa
    45121 attccaaacc cagtttgccg cgatatcagc tgctggcgtt gaagcaaccg cataggcatt
    45181 gagcaactga ggcgatacca aacagattcc gagaacaatt cccaaaattt ggctggttcc
    45241 catcttacga gaaacagacc aagtaatccc tactggtaag aactggaaga tagcttcacc
    45301 aggcaaccaa aggaagtgat taacccctgc ccaaaactga gaggattctg tgatggtctt
    45361 gccatccaac atcgaccaat ggacaccttc caagacatta cggaaaccga ggatcaatcc
    45421 tccgactatc aaggctggaa taatcggagt aaaaatctcc gccagagtgg tcataacaca
    45481 ttggaccacg ttttgattac tcttagctgc agacttggct gcttctttgg aaacaccctc
    45541 aatacctgaa acggctgtaa aatcattata aaagatgggc acgtcatttc caatgattac
    45601 ctgaaattga cctgcatttg taaaagttcc tttaacagct ggaattgact cgatagcttt
    45661 aacattagcc ttcttatcat ctcctaaaac aaagcgcatc cgtgtcgcac agtgagttac
    45721 ggcagtcaca ttttctttgc ctccaattgc ctgaagcaga tctttggctt cttgttcaaa
    45781 ttttcccatt tgattctcct tatacttgtc aaagcaagtt tgatttgata agtatattgt
    45841 aaacgatacc aaacttgtct gcaacttgtt tggtataaaa agggtgtttt tttgtaaatt
    45901 ttctagcact tgtatggtaa aatagataca ggtgttcatt aaactagact gaaaacctat
    45961 ttaagcaggc aaaatgaaga aataccaaca attatttaag caaatccaag aaaccattca
    46021 aaacgagact tacgctgtcg gagatttcct tcctagcgag cacgacctta tggagcaata
    46081 tcaagtgagt cgtgataccg tccgaaaggc cctgtctctc ctccaagagg aaggattgat
    46141 caaaaagata agagggcaag gttctcaagt cgtcaaagaa gaaaccgtca atttccctgt
    46201 atccaaccta accagctacc aagaactagt taaagaactt ggactgcgct ctaaaaccaa
    46261 cgtggtcagt ctggacaaga ttattattga taaaaaatcc tcactgataa ccggtttccc
    46321 agagtttcgg atggtttgga aggtggtccg ccagcgtgtg gtggatgatc tggtatccgt
    46381 tctggataca gactatctgg atatggaact catcccaaat ctcactcgcc aaattgctga
    46441 gcagtctatc tattcttata tagaaaatgg cctcaaactc cttattgatt atgctcagaa
    46501 ggaaatcacc attgaccact caagcgaccg agacaagatt ctcatggaca ttggcaaaga
    46561 cccttatgtc gtttcgatta aatcaaaagt ctatctccaa gacgggcgcc aatttcagtt
    46621 taccgaaagt cgccataagt tagaaaaatt tagatttgta gattttgcaa aacgcaagaa
    46681 ataaaagact gagacaccag atctcagcct ttttctttat cccaaaacta attcatcact
    46741 gaccagactt tggccactat ttttctggaa gagatgcata aggtcttcaa ctgtcagatg
    46801 ctttttctct tctcccttga catccaccac tatcttgcct tgatagagca taatgagacg
    46861 attgccgtac tcaatcgcat gattcatatc atgggtaatc atcaaagtcg tccactgatg
    46921 gtactccaca atcttttgcg tcaagtccat caccatttga ctggttttcg ggtcaagtgc
    46981 cgcagtatgt tcatccaaaa gcaaaagttt gagtttcacc agagctgcca tgactagggt
    47041 caaagcctgt ctttgtcctc ctgagagata ttgagtatct acttttaagc ggttttcaag
    47101 accaatattc aactccttca aggcctcttg gaactggatt ctatccttct ccttcacgcc
    47161 ccaaccaagc cctctctttt gcccacgtct caaggcaata gccatattct cctcaatcgt
    47221 caaacgagaa gctgttccca tcttaggatc ttgaaaaaca cgggcaatat ccttggctct
    47281 ctttctgaca ctcagatgtt taatggattt ccctgccagt agaaggtccc cttcgtccac
    47341 cgatagatta ccagccaaga tattcatcaa agtggatttt cctgctccat ttctaccaat
    47401 cacagagata aaatctccct cttcaacctc taaatctaat cctttgagga catggttctc
    47461 attgaccgtc cctgcttcaa atgtcttgtg aatattttca agtgttaaca aacttgccat
    47521 aactttctcc tcctattcat ttctcaattt cagaccacga atctttaatc tcttttgcaa
    47581 ttctggtgca aataaaacca aagcgagcaa gattgcatta aagagacgta ccaagttttg
    47641 atctagattt ggaatttcat agatatttaa aataatcaaa cggtaaacaa tagcaccgat
    47701 tccgatggat aataagtggc ctccaatggt caagtcgtgt atcaagactt ccgagctcaa
    47761 accaacaaca atggttcctg tcccagaagt cacatctgaa aatccatcat tttgggcaaa
    47821 caaggaacca catagggcaa tcaaaccgtt tgaaatcatg taaccaacaa tcttcatggt
    47881 gtttacattg actccattgg cctcactcat cgggatattg tccccagtcg aacgcaagac
    47941 caaaccaatc tctgttttca tcaaaagggt caagaccaaa caagtaagag acagactaaa
    48001 ctaagtgaga aaacagctcc ttcatttgtc agacccaagc tcgccaactg tttaaagacg
    48061 gttgcagaat ctcccaagga aagattgggt acactgccca taattttaat attgattgaa
    48121 tagagccctg tcaaggtcac aatccctgtc aagagagctg ggattttcat attggtgtgg
    48181 agcattcctg atacaagacc tgctaccata cctgccacca aagcaagtaa agtcgcaagc
    48241 caaggatttg cccctgcctg tatctgtgat acaacgactg ctgcccccag aggaaaggct
    48301 ccctcagcag tcatatccgc aatattcaaa atacggaaag tcaagtagac cccaattgcc
    48361 ataatcgacc acaacaaacc ttctgataaa ctagataaca caaaattcat cttaatcctc
    48421 cttattcctt gccttctaac ttactaatat caattcccaa tgcatctgcc atttcttgat
    48481 tggtatgcaa ttccagtttt tcaggcaact caactgctat attttctggt ttctcacctt
    48541 ttaaaacacg aatcagcatg cgagctgtct gccgtcccaa ttcttcataa ttggttccgt
    48601 agttatacaa gccaccaaca gcaatcattt ctgttgaacc accgaatact ggaaccttgt
    48661 gtttaataga aacctgctta actgtttcca tggttgacga aatgatatta tcagttggga
    48721 caaaaaccat atccacctct gccatcaaac tctctgctgc cgccttgacg ttattactgt
    48781 ccaagattgt tttttcaaca acggtaaagc ctttttcttt cagaagtcgc ttagcttcat
    48841 ccttttaaac aaccgaattg ggctcgctct gagtatagag gattccaatc gttttagcct
    48901 ttggcaacac tttctttatc aaattgattt gggttgaaat ggcatctgat gactgatcgc
    48961 ttgtcccagt tacattgccc ccaggatgtt ctcttgactc aaccaacttg gcactgactg
    49021 ggtctgttac agctgaaaag ataactggtg tcgtttgcgt cgtattggcc aagctctgag
    49081 cagaaggcct tgcgatggct agaacgacat cgctggattc tgctagttgc tgggaaatcg
    49141 tttttagatt tctttgttct ccctgtgcat tttgcaaatc aatctcaata ttttccccct
    49201 caacatagcc ttgtttggcc agctcatcca caaatccttc tctagtagcg tctaaggact
    49261 ggtgggtaat aaactgcgaa ataccgatac gaaagacatc tttttcttat ctgccttcaa
    49321 ctgatgcaaa ctgatcagag aagtcaagag gagccccact accaagaggg ggctagtgat
    49381 tttcgaacaa ctttcataat gaaactcctt ctcagaaaag ataaaacaaa aaaccgccta
    49441 gatactatct aaacggatac ttgaaataac ctaacaagtt acaacttagc tagtccattt
    49501 agatattcat ctatatggac cacaatcaaa aatcttagcc acatagatac aaacaaattg
    49561 cttgaactgt ttgcatccat ggtgacatgt ctacaaacac tatctaaagt agctaaagta
    49621 aaagttttga ttcatagtta cggcttgtct cttattcatt tctttttctg ctttcttttt
    49681 tgatgcttcc tatcctacca cctttttcat cacctgtcaa taatatttca gaatttttta
    49741 aaatttttcg aaaattcttt caggaagctt tcaaagtttt tcaaatcagt ccaacaaaaa
    49801 aagttttata attcccataa aaattgacat ggaaattata aaaccattac tagtttagtc
    49861 ctttttgata acgtgccaat tcggtttggt tcgcccaaac atagtgacct ggacggattt
    49921 ctaccataga cggcttatca gtctcatagt cgtgttgact tgggtcgtaa accttcaaga
    49981 ccttcttacg ttccaagatt ggatctggga ttggtaccgc tgaaagcaag gcttgagtat
    50041 atgggtgaat tggattgtta aacaattctt ctgtttctgc aacctctaca ataacaccct
    50101 tgtaaataac tgcgatacga tctgaaataa agcgaacaac cgacaagtca tgggcgatga
    50161 agagataggt caggccgagc tctttttgga attttttgag caagttcaag acttgggcac
    50221 gtacagaaac gtccaaggct gaaattggct catctgcaat aacaaagtct ggttgcatga
    50281 ccaaggcacg ggcaataccg atacgttgac gttgaccgcc tgagaattca tgagggtaac
    50341 gagtcaagtg ctcagcaaga agacctactt cacggataat attttgaact ttctctttac
    50401 gttcttcttc atccttaaat aaacggtgat tgtaaagacc ttcagaaata atataatcaa
    50461 cagtcgcacg ttcattcaaa cttgcggcag ggtcttggaa aatcatctgg attcgacgaa
    50521 tcaattccgc agcttgttca cgcgatttct taccattaat cttttgacca tcaaaaatga
    50581 tatctccatt acttgtatca tttagaccga tgatagcacg accaatagtt gttttcccac
    50641 taccggactc acctacaagc gagaaagttt ctcccttgtt gataaagaag ttagcatttt
    50701 taaccgcgac aaacttctta cttccttcac cgaaggaaat ttctaaatct ttgatttcta
    50761 ctaatttttc agacatttcc ttcctcctag tcagccagat gggcaaatcc cattttttca
    50821 cggatcttat catggagatt tgcaatcaca gctggttttt ctacttttgg agcatcctca
    50881 tgaagaagcc aagttttagc ccaatgtgtc tctgatactg agaattgagg agctttttgt
    50941 tcgaagtcaa tctgcattgc gtagtcagaa cgcaaggcaa aagcatcccc tttcaggtca
    51001 gtataaagtg acggaggtgt tcctgggatt gagtaaagat cccctttatc atcagcaagc
    51061 tgaggcaagc tagacaagag actccatgta tatggatggc gagggtcata gaagacttcc
    51121 tcaaccgttc catactcaac gatttctcct gcatacataa ccgctacctt atccgcaata
    51181 cttgccacca caccaaggtc gtgggtaata aagattgttg tgaaatgata ctcgttttgt
    51241 aaagatttta gcaaatcaat aatctgagct tgaatagtta catccaaggc agttgttggc
    51301 tcatcacaga tcaagacatc aggtcggcag gcaagggcaa tcgcaataac gatacgttga
    51361 cgcattcctc cagaatattg gaatgggtat tcattaaaac gtctatctgc gtctggaatg
    51421 ccaaccttat tcatgtagtc aatggccaat tctttcgctt ctttagctgt ttttccttgg
    51481 tgttttacaa taacttctgt aatctgacta ccaattgttt taatggggtc caaactagtc
    51541 attgggtcct ggaagatagt cgcaatctta gcaccacgaa tttgttccca atccttgtga
    51601 gaagataaag ctgtcaagtc ctgaccacgg tagtcaatac taccttgggc aatacgacca
    51661 ttttcttcga gcatacctgt gaaggtcttt gtcaaaacag atttacctga tcctgactca
    51721 cctaccaagg ctaatacttc tccttcaact agttcaaggg aaacgccgcg aatggctgtc
    51781 aatactttgt cacgaacgtc aaattccacg acaatatcgc gagcagtcaa aattacattt
    51841 ttttcttttg tcatttctac tcctatctat gtgtacgtgg atcactagca tccgctaagt
    51901 tttgaccaac tacgaaaagg gacaaggata ccaagacaag ggttgtcaat ggaatccaga
    51961 acaagtaagc attggttgtt acgttttgtg aataatccga aatcaaacga cccaaacttg
    52021 gcactgtaat cggtaatcca agaccgaaga aagacaagaa ggcttcgtat gagataaagc
    52081 ttggaagcat ttgagtcatg gttgtcacaa taacagatac caattgaggc atgatatttt
    52141 tggcaacaat cttcaaggtt ggtgttccca aagtacgtga cgccaagttg tattccaagt
    52201 cacgatagcg caagatttgc acacggatca tgaaggcaat accaatccat gttgttacgc
    52261 tcatggcaaa aatcagattc cagaatccag ctccgattga gtaagtcaag acaataacaa
    52321 tcaaaagagg tgggatgttt gagatgacgt tgtaaacttc catcatgaca cggtcaactg
    52381 attttgaaat accccaaata ccaccgacaa aaacaccgat aaccaagtta atcactgtcg
    52441 caatcacaga aatgaggatg gagttacgag ctccgaacca gacaccgtca aagagcgatt
    52501 taccgttact gtcagtaccg aaccaatgct ccgcatttgg cttgatataa cgaacactaa
    52561 agtcgtttac cttgctgaca tcattgaaat caaacttaga aaacattggg tagatgaaac
    52621 ttatcaaaat gatggctacc aagattccca acatgactac agttgatttt ttcttcataa
    52681 attgtttaaa cactgatttc cagtaagaat atgctggcgc atcaatagtt tcagaggcaa
    52741 aatcgtcacg ttttacaaac tgaaattttt ctttatcgat tgtagacatt atttgcctcc
    52801 tttctcagtc aatttaatac gtgggtcaat aatagtcatc caaatatctc ccaaaagacg
    52861 tgagaagata gaaatacatg taaagatgaa gacaagacca acgaccatag agttattaga
    52921 tgcttttaca gagtcaatca acattttacc catacctggg aaggcgaaga ctgtttcagt
    52981 aagggttgca ccaccgataa ccccaataat ggcaccagga attcctgaaa ccagcggaac
    53041 catggcattt ttaaagatgt gtttgtttga aatttctttt tcagacaaac cttttgcacg
    53101 agcgaaacga acaaagtctt gagattgcaa gtcaatcatg taacgacgaa tccaaatggc
    53161 tgtaacagga gcacccaaca aaccaaggat gactgctggt aaaacgtaag aacgccaatc
    53221 tccagctccc aagataggga atgaatctgg aagggcaata gatgatccaa tcaatcgaac
    53281 gatgtaaacc aaggcaatcg ttggaagagc aagcaagaag gtcaaagtcc ctgttgagag
    53341 gctatcaatc caagtgttct tgaaacgagc catggctgaa ccaagtggca cggcaagagc
    53401 ataggcaaga accaaaccaa tcaaaccagt aatagcagag ctgacaatca tagatggata
    53461 ttggtaatta ctttcagtcg ctgtataagg atcatctttc ccatagctag ctacttcacg
    53521 agagtcagcc tgactaggtg acttgtaggt tcttgagtaa atatttacag aagacgtttt
    53581 cttacctgtt gggaactgaa cttgggcagt tttggtttgt ccttgacctt gagtaataac
    53641 ctgaagaact ggtgtattag cataggttgg gtaagagtca cctaaattca agttcacaaa
    53701 gttttgatga acaaatggga actgactgtt aaagtacaag agatatttat gtttagttcc
    53761 tgaaccgacc aatgaccatc cgatagctgg atcattttca aaacgaaggt agcgtttcaa
    53821 gtctggattt tcagggtctt ggattttatt tgtatggtca atgtcaatca agttagcata
    53881 gaagtgaaaa acacgttcaa aaattggaat ttcacgagta gcatagaatt gaccactttc
    53941 agtaaattct cccaaagtcc aaccatgacc taattgattg atgtactttt cataaatagc
    54001 tttattggtc gcatttgctt ctactgttac agaagaatcc atgctacttg ccttttcttg
    54061 caactcttta gtatcgtaat actcaatgta gcccatacgc tcaaacacag tattttcata
    54121 gttatcacgt ttatcagccg ttgtcgcaat tttattatag ttaggatcct gcttgaaaat
    54181 caattttcga ggaaccaagg tatagataat cgtgtaggtc aaagtcgtta ctaagaaaat
    54241 cgaaaccaat gaccgcaaaa cacgcataaa aatatatttt ttcatattat ttcctttaaa
    54301 aatcccaaaa gaaccttctc ctcatggaga gaaagttcta ttagaaatta tttacttcac
    54361 atgacttgcc aattcttttt gagctttctc atttgattca gctttttctt tcaaccattt
    54421 ttcacgagct ttttcatact cttccttagt caccacttta tcttgtaatt tcaaatattt
    54481 gaagtaaaca tctgacccct tagagcctgt ttgcgcagaa gctccagtaa atggaacaat
    54541 tcgtgaaagc actggtgctg caccagaaga agccatagca ggaataaaga gtgaactatc
    54601 tgtcaaccat gcttgagccg ctgcatattt ttcataacgg acattcaagt cgcttgtctc
    54661 tttggcagct tcatcaacta atttatcgta ttctttcaaa ccaacttgaa ctactgaagg
    54721 gctatttgga ttatcaaatc ctaaatatgt ttttgtagtt tcactgctag ttgtttttaa
    54781 aatatccagg taagtagatg ggtcttgata gtctggcccc catgaaactc ctcccgatac
    54841 atcccaatcc tcagatgaag cattggcagc atagtaagta atattaagga attcatcact
    54901 tgtcatttgt tgaatatcaa caacgacatt ttcaacacca agaactgttt ctacagattg
    54961 tttaaaggac tgaatacgag atatatagtt ttttgatgct tggtctactg gaacgtccag
    55021 atgaatagga aactgaacgc cgtctgcttc taaagctttc ttagctttcg caaactctgc
    55081 cttggccttg tcagcattga ataaaccatc ctgcccatca gctaaattca cacctttcca
    55141 ctcatcacca taagcaggaa gttgagcagc gactaaatca ccaaaggtct tctcaccagc
    55201 tgaaacaaag tctggtttta caaataaatt acgaactgct aaagctgctc catctttacc
    55261 attgatttga gctgagtaag ctgagcgatc aagagcaaaa ttcaaggctt gacggaaatc
    55321 tttgttaagc aatgccttct tagtagctac tttctctgaa tctgtagttt tagaagtata
    55381 gttgtaactt tggcgatcaa tattcacacc cagaccagca atcccagagc ctgattgtgt
    55441 gtaatagata ttgtccttgt attcttctgc aaccttagaa tagttggagc tggtagggta
    55501 aagacgggca taactataag ctccactagt gaagttacgc tctagcgact cctgatctga
    55561 tccatcatag taagctagat tgatagtatc taggtggaca ttttctttat cccaatattg
    55621 ctcatttttt acaaactcta cagaagattt tgcagtcaac cctttcaaca agaatggacc
    55681 attataaagc aaggatgtcg gatctgttgg tttagcaaaa tcgcttcctt ttgatgtttc
    55741 gaattcttca ttcagaggcc agaaaataga ataggtcaac ttagagttcc agaacggttc
    55801 aggctggttc aaagtgtatt gtaacgtata atcatcaacc gccttgacac caactgttga
    55861 aaaatctgtt gaagttcctg atagataatc tgccaagcct ttaaccgaat tttcagctaa
    55921 atacatagct tctgattttt tatctgctgc gtgttttaaa ccgttcacga aatctttagc
    55981 cgtcacctct gcatattctt ctccatcaga ggtaaaccat ttaacccctt tacgaatctt
    56041 ataagtgtag gtcaaaccat ccttagagac ttcccaatcc tctgcaactg caggagcaag
    56101 attaccgtaa ttatcgttag tgaataaacc atcaatccca tttgaagtca ctactgttgt
    56161 actattttta cttgaaatca ggtagtccaa ggtttctggg tctgctgtat aaacatagcc
    56221 ataagcttta ggggctgatg aatcagatga ttttgaagaa ctgcatgctg caagtacacc
    56281 tgctgctaat aaaacaagac ctgctgtagc aaatacacga ttttttttca ttttctactc
    56341 ctctgtttat gtgaattata gattgacaac cattatatca cattatccat taaaaatcaa
    56401 acaaattttc agaatattta ggcttgttgg cacaaatttt tcattttttt tgaatatatg
    56461 attcaaattg tcgttcgaag tgtcaaagac tacagtgaaa ataggaaatt tgacacagaa
    56521 attttggagc ttaggaagac atacagtaaa atgaaatacg gacggaacaa tgtgattttg
    56581 gaattcaaat taaattataa caatattgta gaagtatcat tctagtattc aagattcagt
    56641 ttactatgtc ttttcacacc aaccttattc cgaattcaat tactttcgtg atttacacat
    56701 atagattaag actatctttt atactttaaa atttctcgct accttgtcca ctatatgctc
    56761 ctcgctatca cgtttctatt catagcctac gatttcacta ttgctttctc tgacaattct
    56821 tatttcctgc gtcagactta aaacgatcta tccccagacc attttaatcc gctacctcac
    56881 gatagtcagg cttggggagc gctattgtat tcaccggtag tggatcccta cagaggactt
    56941 acacctcaga tgcacgacat gcccatcgta taaaaaaatc tcctacccaa ggtagaagat
    57001 ttcaaactta taaaacttaa tccgtcatgt ccgataccaa cattcgatgc tccaatggaa
    57061 tactgcacat aactagcaag aaaataaagc ctgactgaat ccagaagaga gccaagtcaa
    57121 aaattccgtg cacagcaacc actgtaagga aagatagata aaggccgata atcggacgtt
    57181 tccccgactc ctgactcata tccatcatca agcgaacagg agcaacagaa gacaaaacta
    57241 ataaaatggt acccacaatt ccgtaactca gaatcgtatc aatataaaga ctgtgggcat
    57301 gttcatgata aggagcatgt atccgaggat aagagtgcat ataggtcaat ggcccttcac
    57361 cccaaaaagg attttgctta aacaaggcca tcccagcatc ccagatagaa atgcgttctt
    57421 ccatagaaga gtctaaagta cccattcgaa ctcccaaatc actagaaaag aggaaactca
    57481 aaccaatcgc gaagacccca atactaagcc aaaaggcctt ccagttttta atagtcgtaa
    57541 agagatagat aattgctcca gcgataatag caggaaaggc agttcgattt tgagtaaagt
    57601 tcaaaccaaa gagattaaca aagcctgcaa tcacacagaa tactttcaac caattcaact
    57661 tggtcgttgt aaacagatag aaagcaatca taatacagaa acaacaaata attccataat
    57721 aattaggatt aaagaaggtc acttctgccc ggttctgatg ccacacctgc atattgggtg
    57781 aaagaaaagc atagttaaat ttcttcacaa tttggaaatg ttctaaactg gcaaaagcag
    57841 ctgacaagac actaccaaac aagacgaact gcaaaatcaa tcgaaagaat ttatgggata
    57901 aaatcgactg atagtgcaaa aagaaaatag taaatagaaa cattcctact gaagccacaa
    57961 gacccatcca attttgtgca agaatggata taacagtact atagctaaga aaaagaagca
    58021 gcatcggatg ctcccccatt ttctgaagaa tacttttcat gtctcctgta aaaatcaaac
    58081 tgataatata taaacagagt acaactacaa aaagataaaa gggtaaaaag atacttagga
    58141 taattcccaa taaaatcagc tctttactag acaacccctt cagcttttca ataaagccta
    58201 ttgatttcaa aatgaatcct ttctctccaa atcagctgat tcagataata gtaagctatc
    58261 ctatattgta ccactttttt agcaatttga aaacaaagga aacgttttcc aaaataaaaa
    58321 ccctatttta tccaccatat caaggcttca aaatgatact tcaactccat tctcaattac
    58381 ccgataagtc tgattttgca aatcaatttc tactactgct gttacggact tatctttatt
    58441 ttgacgtttg attacaatgc tgtgagctgt tggtgtctct atctcagtag tcccttctag
    58501 atcaaaggct tctgaacggt tacggaaaga aaatagattg agaagggcct tcacaacagg
    58561 tcgttgcact tcttttgcta tttcctcgtt gctatagtaa tgacgattaa tatttcgacc
    58621 ttctttagtt tcttctaata atttcaagtc attcttgcct gctaatagac ccacatagta
    58681 aacctgagga atacctgggg caaaagcttg aattagacga gcgagaaaat acttgacatc
    58741 atcatctcca agcgctgaat agtaggttga attgatttgg tagatatcta agttgttata
    58801 ctcggcacta gagtacttac gtttgacatt ggctccaacc ttatagagtt catttgaagc
    58861 atagtcaatc tcctcatcgg tcaggatatc cttgacatct actactccaa tcccatcatg
    58921 ggtatctagc gtcgtaaatt gcttcatcgg gctcatcttt aaccacttag ccaaacgctc
    58981 tgttctggaa ctgtaaagag tataaagtgt caccattgga agagcaaaat cataaacata
    59041 gtaatcatgg tctgctattt taaactgaat cgaatagtgt tcatgaatct caggtaaaag
    59101 ctctgtccca tactcagcag cgatatctcg aactttgtcc aataaatccc aaatatctgg
    59161 ttccacaaag aaatcattag tatccaattt cttcactgca taagcaaagg catctagacg
    59221 aatcaaatca cacccattac ttgccaagtg ctgaatggtc ttacggataa attccatagt
    59281 tacttctttg gtcacatcaa gatcaatctg ctcttcacca aaggtattcc acaaatgttc
    59341 cactgaacca tcttcaaaca caatctcttg ctttggtgca cgatccttac gcttgtaaat
    59401 taaatctaca tcagactgtg tcggacggtt ttctggccaa aacttatccc agtttaaaaa
    59461 gagagcttta aattcactgg cttcatgttt ttcttgatag tccttataat acttggattg
    59521 acgagaaata tgattaatca taaaatcaaa cataagataa tatctctcac ctaaacgctt
    59581 aacatcctcc caatcaccaa aagctgagtc cacttcgtcg tagtcaactg gcgcaaatcc
    59641 acgatcacct gttgatggga aaaatggtaa aaggtgaact cctccaatag catctcgaaa
    59701 atgctcttcc aaattatcat ataagtcttt aagattattt ccaaggctat cagaataggt
    59761 aatcaacatg gttttatttt gaattggcat cattactctc ctttttctaa ttgaagccaa
    59821 gtctcatatg atctggcttc ataaataaaa ttcattttaa atctctattt atcatcaaac
    59881 tcgtactaat atagactgtg ataaacaaag tactactttc ttgttttcta catagaatta
    59941 tcaacaagct gaactcttcc tctgtgtcaa agactataga ttccatgagc tcttcttata
    60001 ctattcgaaa atctcttcaa accacgtcag cgttgcctta ccgtaggtat ggttactgac
    60061 ttcgtcagtt tcatccacaa cctcaaaaca gtgttttgag caacctgcgg ctagcttcct
    60121 agtttgctct ttgattttca ttgagtatta cttcactgcc ccgttgctca ttcctgaaat
    60181 gatatggcgt tggaagaaga gatagacaat ggtgatactg ataatgccga ccacgtaaga
    60241 ggcaaagctt ggtccgtagt cgttgaaata ttggcctgcg tagttgtatt ggaacaaagg
    60301 cagagtccac attttggaat cccggttcaa gacaaggagt ggcaacatga agtcattcca
    60361 gaaccaaagg gcattgatga tcatggttgt cgcatgcatc ggtttcatca ttgggaagat
    60421 gatgcggaaa taggttgtaa attgattagc cccatcgatc tctgctgctt catccagact
    60481 ttctggaatc gagattttga tatagccaac atagagaaag agggtctgtg gaatcgcata
    60541 ggtcaagtag agcaagatca aaccaaaggt attagccaaa ccgagtttac tcatcataac
    60601 cgtaatcgga atcatgatga cttggaaagg tacgaagatt ccgaggatta agagggtata
    60661 catgatggta aaggcttttc ttttactcat attgcgagcg atggagtagg ctgccatagg
    60721 gataaagatc attactgcaa gtaaagacaa gacagtgatg acgacagagt tccaataata
    60781 gcctccaatc ccatcagcta agagacggct aaagttgtcc catgtgaagt tggttggaaa
    60841 accaaagaaa ttatctacaa tatccttagt gggtttgaag gaactaaaga gggtagcaag
    60901 gagcggcact aaaatcagaa ccgttcctag aatcaataga atgtatttgc caatcagggc
    60961 ttttctttca tcttgtttca tcatgcttct cctcttaaat ttcaaatttc ttagatactc
    61021 tcaattggat gatcgaaatc actacaatta agaagaacaa gattacggca atggcattgg
    61081 cataaccgaa ttggttgttt ttaaaggcat agttataaac caagagccca agtgaggttg
    61141 tggcattgtt tggaccacca ccggtcatgg caaagacttg gtcaaaggca gtcagcccac
    61201 cttttagggc taggataaag actatagaga cacttggtag caagtaaggc aattcaatgt
    61261 tccagaaaac ttgcttgcta gtcgcaccat caatccttgc tgcctctgta atctcagttg
    61321 gaatagattg caaaccagct aggaagatga tgatgggcat agccacccct tgccaaagaa
    61381 ggacaaagac agccgcaaag attgctcccc acttagtccc taaaagactg gtttggagaa
    61441 attcaatatg aagggcattc ccaatcgctg gaagaccgta gttgaagact tgcttgaaga
    61501 tcaaagccac tgtcaaacca gataaaacag ctgggaagaa gaaccaagca cggaagaagg
    61561 tttggccttt gattttagaa ttcaagacac gcgcaatgaa gatcccgagt gcaatctcac
    61621 caaccaccat ggcaatcgta atgattgcgg taaagccaat cgcattcatg aattttggat
    61681 ccatgaagag gagcttaaag ttgtttaagc cgacaaattt gtagttataa gtcaatcctg
    61741 tccagttggt aaaactgtaa aaggctcctt gaaacatcgg cacatagaag aaaattgctt
    61801 gtaacaagag ggggatgacc acaaaagccc atgcccaata tttttgtaat acttttttca
    61861 tagtctctct actcctaatc cacatccgct ttcatcgggt taaagaaggc attcaaatca
    61921 ttgaccatgc cttgtttatc accggtcaag acatagttca tggtcaaggt atggaagtct
    61981 gcttcactgg tccagtattg ttgcaaccag accaagtgac gatccgtaaa ggcatattcg
    62041 gtcataccag caagcggtga atcttctcct gcttgtttga ccccttcgat cgctgttgga
    62101 gatccgtcca catcgtagta tttttgcatg acttctggac gggtcatata ttccacaaag
    62161 gcattggctt cttttggatg tttggtggtg gctgagatag accatgccaa gtctcccgca
    62221 ccaacggtta agctttgtcc tttttctttt cctggaatca tgaaggtccc aatcttaaag
    62281 ttcggttttt gttcattaat cgctgtgatc gcccaagacc catttggtgt catgaggaca
    62341 tccccacgtg cgaaggctcc gataacatcg gtatagccag caccttccca gttcttttgc
    62401 ttagagccat tgatgcgaag gatgtccatg accttgatgt catctttcat aatcggatcc
    62461 gacaatttaa tggcatttgg ttgagaataa cgaaggtatt gatttgcttc ttttcctcca
    62521 cctgttgctg tcgcaaaggc taattgattg taaccattga gtgtccaagc atctgcacct
    62581 gcaattccaa atggtgtttg tcctttagca acgatatctt tgactaactg ttcaaattca
    62641 tcccaggttt caggaacttt caagcccagt tcttcgaatt tatctttgtt gtagtaaatt
    62701 ccataagcat tagctgtaaa aggaacgttg taaacttttt cgtttacagc atatttttca
    62761 gcgtagccat ttttcacgcg tttcaggtag tctttgttac tcaaatcttc aaagacacct
    62821 gcttttgccc attcttgcag ttcgatggac tgtgggtaaa tattgaccac atcaggcaca
    62881 tctcctgcga gaacgcgtgt cttcaatact tcaccagcat ttggtacatt gacgactttg
    62941 acctttatct tagggttttc cttctcaaaa tcacgagtga tttcttccaa ggttttggtc
    63001 atttcttttt tctggttgaa atactcgatg gtcactgtgt catccgcaga tttaccatag
    63061 ttggagcaag caccgagccc aaacaaagct aaacctgtag ttgcaagaag tccgattttt
    63121 ttataccatt ccattagaaa gcctccttta taaatttata cacccttatc aaactgcacc
    63181 tcaaaagtta gatagaataa atctaacttt tgaggtcagt acatatcata gttttctaaa
    63241 aatatactgt ctactcaaaa aatctccttg ggataagata acagttaagc ccgcatacat
    63301 tagttctgca cctgagtaaa cttcgccatt ttcctgtaat ttatatagtc cctcttcatc
    63361 caaatctttt aattttaaag ttgtttccat ggtctctaca acagataaaa cgcgaacgta
    63421 ggttacaatc gtttgatttc cgtaattaaa ttgtacagct gcttcattgg atgcagtatc
    63481 aggattaatt agtctatact gctgtcctaa ctgaactact ggtcgtaatt ctttatacaa
    63541 gttcacctga ttagcaatcg tagctttctc ttcatctgat aaatttgtca aatcaagttc
    63601 atagcccaaa tttcccatca ttgctacaag gccacgtgtt tctaatggtg tcattcgtcc
    63661 catctgatga tttggtactg ctgacacatg agcccccata gaaatggttg gatagagata
    63721 ggatgaaccg tattgaattg gtaaacgtgc aatggcatca gtattatcac tagcccagac
    63781 ttgtgggaaa tagcgcatca taccaagatc atttcgtcca ccaccaccag agcaggactc
    63841 aaagagaata tggctgtgct tctctgtcag ataagaaacg agttcgtaaa gccccagcat
    63901 gtactgatga gattgcatct gtgtctctag ataagttaat ccattcccta gcttagtgat
    63961 attgcggttc atatcccatt taatgtaatc aatatcatga taagatagga gttgatctaa
    64021 gacacttttc aagtattcta ctacctgagg attggcaaga ttaagtacta attgattccg
    64081 agaataagta tgctcatagt caggaacctg aatagcccag tcaggatgtc gacgatacaa
    64141 atcactatct acagaaatca tttcgggttc taaccaaagt ccaaactgca aacctctttc
    64201 atggatagct gaaatcagac tttctagact tccacccagt ttttcctcat taacaaccca
    64261 atcacctaaa gcacgattat catcaaaacg attgccaaac caaccatcat ctaatacaaa
    64321 aagttcaatg ccaactttct tagcttcatc tgctaactct aacagttttt ctctctgaaa
    64381 gtcaaagtaa gtagcttccc agttattgat tagaattgga cgttcttttt tagaaaattc
    64441 acttagcata atgtgcttca gtacaaaatt ctgactttca tgactaatac cagttaatcc
    64501 ctgatctgaa tgagtcacta aagctaccgg tgtttcaaag tattcctcag gggctaactt
    64561 ccaagaaaag ttttctggat taatgccaat agccacccga acttcattca attgattttt
    64621 ttgaacaaaa gcttcaaagt tgccactata cattagttga atagcaaaca cattcccagc
    64681 atcctctgtg actccttgtt cgcatagtag aagagctggt gtttgagtat gaccagaagc
    64741 acctcggttt gagctaatcg aaaagattcc ttgttctacc tgttgacgtc taacagtctt
    64801 ttcacgagca taagcaccct gcagagttac tatttcgtaa tctgcagctg gaaaatcagc
    64861 cataaaagaa aaatctttat ggatgacaac ttcctgatta ctattattat ctaatttact
    64921 gtagctagca atagtcgcat cattattaaa agtagtataa tacaaagtca gactaagttg
    64981 agccttagaa tcttctaaca ttaagacaag agtctctgta tcgtccatgc tatgtggaga
    65041 aggtaagccc tgtggaccat tctgaccttt taaaatcttt gcttctacaa atcgaaagtc
    65101 tgttacttca gttacactat gctgaacctg tatggttggt ttcctaaaat ctcctaagcc
    65161 atgttgtcca aaaatctgtc gctgagtatc taaactaaag gttcgattag tagccgttgg
    65221 atttcctgaa aaggcatggt ctcgttcata aacactattg gaacctttat agttcttaat
    65281 agtctttcct aaatgtttca aaagtaagta gccattttga ttttcaataa tcaaacttag
    65341 atttttactc tcaacataaa atagattatt ctctatccta actcccattt acttcacctc
    65401 atcactttat tgattatatt ttatcacctg aaatcgcttt ccaaaataga aaaatgtctc
    65461 aagaatatgg taaaatgtta ggtgggaggt agcacatgtt agttttttca gaataccaga
    65521 ctggaacaat cgaccttgcc ctaagctttt atggatatga ggaatgcaca cctaattact
    65581 cttttggtcc agccattcgt gatacatacg ttctacatta cattactaaa ggacaaggaa
    65641 aattttatta caagggtaaa attgttgatt taaaagaagg agatttcttt ctattaaaac
    65701 cagaggaact aaccttttat caagcagata gtaaagaacc ttgggcctac tactggttag
    65761 gaatcactgg agggaaatcc cctgattatt ttgctctttc tcaaatttct gatcaatcct
    65821 atctcatcca atctgaaact tgtcataccc agactactgc aaaactcatc tcagacattg
    65881 tccgcttcgc tcagattaca aaatcaagtg aattagctca actccatatc atgggacaac
    65941 ttcatgaact gatgtttcat ctgggaactg atgtttcatc tgggaactat tgctcccaat
    66001 cagaaaaaaa agaatatttc atcaacccac caactctatc ttgaatgcaa acgattaatt
    66061 gatagccact atcctcaatc acttacaatt caagatttag caaaagaact atccgttcac
    66121 agaagctact tatcaagcgt attcaaagaa tttaatacct tatcacccaa agaataccta
    66181 ctctacgttc gaatgcaccg agctagacaa cttctcgaaa atacccaaga gtccatcaag
    66241 gtaattgcat actcggtagg tttttcagat ccactccatt tttcgaaagc ttataaacaa
    66301 tactttaatc agactccaag tcatacaaga aaagaatact ctcaatacca actagtaaga
    66361 aaggcaacat tatgaaatcc taccaagctg tctaccaaat cctatctaaa gaaaccgact
    66421 atatcagcgg agaaaaaatc gcagaaaaac tatccctaag ccgaacagca atttggaaag
    66481 ccatcaagcg actagaacaa gaaggcattg aaattgatag tatcaaaaat agaggatata
    66541 aactgatgaa tggtgacctt attcttccag agattctaga agaaaatctt ccaattaaag
    66601 tcagctttaa acccgaaaca aaatcaacac aactagatgc aaaagaagca attgatttag
    66661 gccatgaagc aaataccctc tatctagctt cctatcaaac agcaggccga ggccgttttc
    66721 aacgttcctt ctactcacca caaggtggta tttatatgac actccatctt aaaccaaatc
    66781 tcccctatga caaattacca tcctacacac tacttgtagc tggagctgtc tacaaagcca
    66841 ttaagaacct aactttaata gatgtcgaca taaaatgggt caatgatatc tatctaaaca
    66901 atcataaaat tggaggaatc cttactgaag caatgacctc tgtagaaact ggcttagtca
    66961 cagatatcat tattggagta ggtatcaatt tcactattaa agacttccct caggaattaa
    67021 aagaaaaagc tgccagctta tttaaagcta cagctcctat aacaaggaat gaattgatca
    67081 tagaaatctg gcgtgctttc ttcgaaacac cagcagaaga gctattatac ctatacaaaa
    67141 aacagtcatt cattctagga aaagaagtca ctttcacact agagcaaaaa gactacaagg
    67201 gacttgctaa agacatctca gaaaatggaa aacttttagt tcaatgtgat aacggaaaag
    67261 aaatctggct aaatagtggc gaaatttctc tcaatagttg gaagtaaaat aacacaatta
    67321 taatataaac gatataaaaa taacttcaga ttagtaattc aattaagttt tacggatctg
    67381 aagttttatt ggctctaaaa ataaaaaaga gagttacaaa ctctcattaa aacggagaat
    67441 aagggattcg aacccttgcg ccagttaccc gacctaacga tttagcaaac cgtcctcttc
    67501 agcctcttga gtaattctcc aatt
//
LOCUS       DAVLHC010000004        66807 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.004, whole genome shotgun sequence.
ACCESSION   DAVLHC010000004 DAVLHC010000000
VERSION     DAVLHC010000004.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 66807)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 66807)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..66807
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.004"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(190..1938)
                     /locus_tag="VXE25_000244"
     CDS             complement(190..1938)
                     /locus_tag="VXE25_000244"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000828810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0770773.1"
                     /translation="MKRQTVNQTLKRLAVDLANHPFLLFLAFLGTIAQVGLSIYLPIL
                     IGQVIDQVLVAGSSPIFWQIFLQMLLVVIGNTLVQWANPLLYNRLIFSYTRDLRERII
                     HKLHRLPIAFADRQGNGEMVSRVTTDIEQLAAGLTMIFNQFFIGVLMILVSILAMLQI
                     HLLMTLLVLLLTPLSMVISRFIAKRSYHLFQKQTETRGIQTHLIEESLSQQTIIQSFN
                     AQTEFIQRLREAHDNYSGYSQSAIFYSSTVNPSTRFVNALIYALLAGVGAYRIMMGST
                     LTVGRLVTFLNYVQQYTKPFNDISSVLAELQSALACVERIYGVLDSPEVAETGKEVLT
                     SDQVKGAISFKHVSFGYHPEKILIKDLSIDIPAGSKVAIVGPTGAGKSTLINLLMRFY
                     PISSGDILLDGQSIYDYTRVSLRQQFGMVLQETWLTQGTIHDNIAFGNPEASREQVIA
                     AAKAANADFFIQQLPQGYDTKLENAGESLSVGQAQLLTIARVFLAIPKILILDEATSS
                     IDTRTEVLVQDAFAKLMKGRTSFIIAHRLSTIQDADLILVLVDGDIVEYGNHQELMDR
                     KGKYYQMQKAAAFSSE"
     gene            complement(1940..3664)
                     /locus_tag="VXE25_000245"
     CDS             complement(1940..3664)
                     /locus_tag="VXE25_000245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0770774.1"
                     /translation="MKHLLSYFKPYIKESILAPLFKLLEAVFELLVPMVIAGIVDQSL
                     PQGDQGHLWMQIGLLLIFAVIGVLVALIAQFYSAKAAVGFAKELTNDLYRHILSLPKD
                     SRDRLTTSSLVTRLTSDTYQIQTGINQFLRLFLRAPIIVFGAIFMAYRISAELTFWFL
                     VMVAILTIVIVGLSRLVNPLYSSLRKKTDQLVQETRQQLQGMRVIRAFGQEKRELQIF
                     QTLNQVYARLQEKTGFWSSLLTPLTYLIVNGTLLVIIWQGYISIQGGVLSQGALIALI
                     NYLLQILVELVKLAMLINSLNRSYISAKRIKEVFVEAPEDIHSELEQKQVTSDRVLQV
                     QELTFTYPDAAQPSLRDISFDMTQGQILGIIGGTGSGKSSLVQLLLGLYPVDKGNIDL
                     YQNGRSPLNLEQWRSWIASVPQKVELFKGTIRSNLTLGFNQEVTDQELWQALEIAQAK
                     DFVSDKEGLLDALVEAGGRNFSGGQKQRLSIARAVLRQAPFLILDDATSALDTITESK
                     LLKAIRENFPNTSLILISQRTSTLQMADQILLLEKGELLAVGKHDDLMKSSQVYREIN
                     ASQHGKED"
     gene            complement(3724..4662)
                     /gene="msrB"
                     /locus_tag="VXE25_000246"
     CDS             complement(3724..4662)
                     /gene="msrB"
                     /locus_tag="VXE25_000246"
                     /EC_number="1.8.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="HEV0770775.1"
                     /translation="MAEIYLAGGCFWGLEEYFSRISGVLETSVGYANGQVETTNYQLL
                     KETDHAETVQVIYDEKEVSLREILLYYFRVIDPLSINQQGNDRGRQYRTGIYYQDEAD
                     LPAIYTVVQEQERMLGRKIAVEVEQLRHYILAEDYHQDYLRKNPSGYCHIDVTDADKP
                     LIDAANYEKPSQEVLKASLSEESYRVTQEAATEAPFTNAYDQTFEEGIYVDITTGEPL
                     FFAKDKFASGCGWPSFSRPISKELIHYYKDLSHGMERIEVRSRSGSAHLGHVFTDGPR
                     ELGGLRYCINSASLRFVAKDEMEKAGYGYLLPYLNK"
     gene            complement(4804..4881)
                     /locus_tag="VXE25_000247"
                     /pseudo
     CDS             complement(4804..4881)
                     /locus_tag="VXE25_000247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002674100.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            complement(4957..5826)
                     /locus_tag="VXE25_000248"
     CDS             complement(4957..5826)
                     /locus_tag="VXE25_000248"
                     /EC_number="2.7.1.39"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000692406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine kinase"
                     /protein_id="HEV0770776.1"
                     /translation="MKIIVPATSANIGPGFDSVGVAVTKYLQIEVCEERDEWLIEHQI
                     GKWIPHDERNLLLKIALQIVPDLQPRRLKMTSDVPLARGLGSSSSVIVAGIELANQLG
                     QLNLSDHEKLQLATKIEGHPDNVAPAIYGNLVIASSVEGQVSAIVADFPECDFLAYIP
                     NYELRTRDSRSVLPKKLSYKEAVAASSIANVAVAALLAGDMVTAGQAIEGDLFHERYR
                     QDLVREFAMIKQVTKENGAYATYLSGAGPTVMVLASHDKMPTIKAELEKQPFKGKLHD
                     LRVDTQGVRVEAK"
     gene            complement(5828..7114)
                     /locus_tag="VXE25_000249"
     CDS             complement(5828..7114)
                     /locus_tag="VXE25_000249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398744.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine dehydrogenase"
                     /protein_id="HEV0770777.1"
                     /translation="MTVKIALLGFGTVASGVPFLLKENGGKINQSAHSDIKVAKVLVK
                     DEDEKNRLLAAGNDFNFVTNVDDILSDQDITIVVELMGRIEPAKTFITRALEAGKHVV
                     TANKDLLAVHGAELLEIAQANKVALYYEAAVAGGIPILRTLANSLASDKITRVLGVVN
                     GTSNFMVTKMVEEGWSYDDALAEAQRLGFAESDPTNDVDGIDAAYKMVILSQFAFGMK
                     IAFDDVAHKGIRNITPEDVAVAQELGYVVKLVGSIEETSSGIAAEVTPTFLPKAHPLA
                     SVNGVMNAVFVESIGIGESMYYGPGAGQKPTATSVVADIVRIVRRLNDGTIGKDFNEY
                     SRDLVLANPEDVKANYYFSILALDSKGQVLKLAEIFNAQDISFKQILQDGKEGDKARV
                     VIITHKINKAQLENVSAELKKVSEFDLLNTFKVLGE"
     gene            complement(7265..8002)
                     /gene="mecA"
                     /locus_tag="VXE25_000250"
     CDS             complement(7265..8002)
                     /gene="mecA"
                     /locus_tag="VXE25_000250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000782680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adaptor protein MecA"
                     /protein_id="HEV0770778.1"
                     /translation="MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAI
                     LDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKIDQNLDFEDLSDLPDMEELAQMS
                     PDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
                     KLADLVVFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDS
                     DISRSVLQEYGQVLMSHDAVLNLQKIG"
     gene            complement(8202..9236)
                     /locus_tag="VXE25_000251"
     CDS             complement(8202..9236)
                     /locus_tag="VXE25_000251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000461501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prephenate dehydratase"
                     /protein_id="HEV0770779.1"
                     /translation="MFEHYSVADLFANLYKKRKANILALIALFALIAVPFTIKAVRNK
                     NTVKDTTSYSTYLIYKITPPEDSAKTILNHQIGGYSDFYGKLIDGNLNGAYLFNDVEP
                     SELKKIASELDTTETTLKNSTNDYWWKKLTVYYMIDDAGVGVKILTSSKDANDLLEKK
                     IDGLIEKFKHAYANVKIEKLETINSKELNANGETALGLNVKNLILRLVVIGVVCVILV
                     VMGNVLVYLFNPTINRVGDFSQYQIDFVTEITTIANLADVLSYKNTGQELTIVSSNKA
                     ILDKLKQSQEALKGMHFVDLQDVSSLLERDTVLLVEEYGVTRYKKFEQSLQILRNLNR
                     SILGVATFKL"
     gene            complement(9265..10698)
                     /locus_tag="VXE25_000252"
     CDS             complement(9265..10698)
                     /locus_tag="VXE25_000252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen polysaccharide polymerase Wzy family
                     protein"
                     /protein_id="HEV0770780.1"
                     /translation="MIDGKRLLFSLTIVSYALTLVSGIVYLFNNNNVSLLSTLLFLLV
                     SSLIACWNDIKYYLIHFIFYLTIFVFLVSRPTIDYFRDGALDTYHPIAYRFAFIVVMV
                     SILGLTTGGVLARYFIARKKIKVANIGNSLKEVYIKRLRFVSLGVFLLTYPFYFIRLF
                     ERLLYRLQTSYYAYYANFESKLPYFTYILSTFTVYAMCMYLATKPKKLQATAVLVSFI
                     AANTIHLAIGTRNPFILSILFAFVYYFMREQAEKGKWIGFKEKLAIFVGSPILMLAMG
                     VLNYVRDNVQVSHTGFWDILLDFIYKQGTSFGVLARGFLFNSSLPYRDFRNFTFGPVL
                     DYFARGSLGAIFGGKAFEHTTNSVELAIDSNSYAHNLSYLVLNKEYLKGHGIGSSYIM
                     ELYTDYGMIGVFLLSFLLGILFIAMLQVAYRSRTILFALSLLILNNLFFMPRSSFSES
                     FFNLFTMQFWGIVLVIIFVAKMLTKEN"
     gene            complement(10714..11700)
                     /locus_tag="VXE25_000253"
     CDS             complement(10714..11700)
                     /locus_tag="VXE25_000253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000446977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HEV0770781.1"
                     /translation="METALISVIVPVYNVAQYLEKSIASIQKQTYQNLEIILVDDGAT
                     DESGRLCDSIAEQDDRVSVLHKKNEGLSQARNDGMKQAHGDYLIFIDSDDYIHPEMIQ
                     SLYEQLVQEDADVSSCGVMNVYANDESPQSANQDDYFVCDSQTFLKEYLIGEKIPGTI
                     CNKLIKRQIATDLSFPKGLIYEDAYYHFDLIKLAKKYVVNTKPYYYYFHRGDSITTKP
                     YAEKDLAYIDIYQKFYNEVVKNYPDLKEVAFFRLAYAHFFILDKMLLDDQYKQFEAYS
                     QIHRFLKGHAFAISRNSIFRKGRRISALALFINISLYRFLLLKNIEKSKKLH"
     gene            complement(11702..12805)
                     /locus_tag="VXE25_000254"
     CDS             complement(11702..12805)
                     /locus_tag="VXE25_000254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000225894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HEV0770782.1"
                     /translation="MVAKKKILFFMWSFSLGGGAEKILSTIVSNLDPEKYDIDILEME
                     HFDKGYESVPKHVRILKSLQDYRQTRWLRAFLWRMRIYFPRLTRRLLVKDDYDVEVSF
                     TIMNPPLLFSKRREVKKISWIHGSIEELLKDSSKRESHRSQLDAANTIVGISKKTSNS
                     IKEVYPDYASKLQTIYNGYDFQTILEKSQEKIDIEIAPQSICTIGRIEENKGSDRVVE
                     VIRLLYQEGKNYHLYFIGAGDMEEELKKRVKEYGIEDYVHFLGYQKNPYQYLSQTKVL
                     LSMSKQEGFPGVYVEALSLGLPFISTDVGGAEELSQEGRFGQIIESNQEAAQAITNYM
                     TSASNFDVDEASQFIQQFTITKQIEQVEKLLEE"
     gene            complement(12795..13640)
                     /locus_tag="VXE25_000255"
     CDS             complement(12795..13640)
                     /locus_tag="VXE25_000255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001061982.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphorylcholine transferase LicD"
                     /protein_id="HEV0770783.1"
                     /translation="MNNMTDLKAIQARSLEMAEYFVAFCKEHDLLCYLCGGGAIGALR
                     NKGFIPWDDDLDFFMPRKDYEKLAELWPRYADERYFLSKSHKDFVDRNLFITIRDKKT
                     TCIKPYQQDLDLPHGLALDVLPLDYYPKNPAERKKQVRWALIYSLFCAQTIPEKHGAL
                     MKWGSCILLGLTPKSLRYRIWKKAEKEMTKYDLADCDGITELCSGPGYMRNKYPITSF
                     EDNLFLPFEGTEMPIPIGYDVYLRTAFGDYMTPPPADKQVPHHDAVIADMDKSYTEYK
                     GEYGG"
     gene            complement(13919..15193)
                     /gene="psr"
                     /locus_tag="VXE25_000256"
     CDS             complement(13919..15193)
                     /gene="psr"
                     /locus_tag="VXE25_000256"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyisoprenyl-teichoic acid--peptidoglycan
                     teichoic acid transferase Psr"
                     /protein_id="HEV0770784.1"
                     /translation="MSKENPLSHHEQLRYDYLLKNIHYLNEREKNEFAYLQEKLTLAR
                     GNSSSSLEQEREEQVDLPSYANRSRSQSKSQALSFPPKKKRRKLRLKRIFMVIFSLLV
                     CVALAMVFMFLRGYQDASAKKTADARAAQVEVFNGQDTRDGVNILIMGTDGRIGQNSV
                     ETRTDSIMVLNVGGSDKKMKLVSFMRDNLVYIDGYSQVINGRKQTDNKLNVAYELGEQ
                     EGQKGAEMVRQVLKDNFDLDIKYYALVDFQAFATAIDTLFPDGVTIDAQFSTLNGRPL
                     TEATVGDDLYATETESPTQTIKVGKQQMNGSTLLNYARFRDDDEADYGRTKRQQQVLT
                     AILEQIKDPTKLFTGSEALGKVFAMTSTNVPYTFLLTNGLSVLDGAKNGIEKLTIPEL
                     GDWVDAYDVYGGLGLLVDQNKYQTKLAQMGLR"
     gene            complement(15190..16038)
                     /gene="pheA"
                     /locus_tag="VXE25_000257"
     CDS             complement(15190..16038)
                     /gene="pheA"
                     /locus_tag="VXE25_000257"
                     /EC_number="4.2.1.51"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prephenate dehydratase"
                     /protein_id="HEV0770785.1"
                     /translation="MKIAYLGPKGSFSHHVVQTAFPHEELQAFANITDVIKAYEQGLV
                     DYSVVPVENSIEGSVHETLDYLFHQAHIQAVAEIVQPIHQQLMVVPGHTKIEKIFSHP
                     QALAQGKKFIDEQYPEAQIEVTASTAYAARFISEHPDQPFAAVAPRSSAEEYGLELIA
                     EDIQEMEANFTRFWVLGAEKPSIPLQAQTEKMSLALTLPDNLPGALYKALSTFAWRGI
                     DLTKIESRPLKTALGEYFFIIDVDYTDKDLVHFAQKELEAIGIQYKILGAYPIYPISD
                     HGKERR"
     gene            complement(16035..16511)
                     /locus_tag="VXE25_000258"
     CDS             complement(16035..16511)
                     /locus_tag="VXE25_000258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate kinase"
                     /protein_id="HEV0770786.1"
                     /translation="MAKVLLGFMGAGKSTIARGLDPNYLDMDALIEKRLGMSIANFFA
                     EKGEAAFRQVESEVLADLLQTDQVVSTGGGVVISQRNRDLLKTNTDNIYLKADFETLY
                     QRIAADKDNQRPLFLNNSKEELVAIFQERQAWYEEVASRVLDVTKLSPEEIIEELR"
     gene            complement(16504..17787)
                     /gene="aroA"
                     /locus_tag="VXE25_000259"
     CDS             complement(16504..17787)
                     /gene="aroA"
                     /locus_tag="VXE25_000259"
                     /EC_number="2.5.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004236106.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="HEV0770787.1"
                     /translation="MKLKTNIRHLHGSIRVPGDKSISHRSIIFGSLAEGETKVYDILR
                     GEDVLSTMQVFRDLGVEIEDKDGVITIQGVGMAGLKAPQNALNMGNSGTSIRLISGVL
                     AGADFEVEMFGDDSLSKRPMDRVTLPLKKMGVSISGQTERDLPPLRLKGTKNLRPIHY
                     ELPIASAQVKSALMFAALQAKGESVIIEKEYTRNHTEDMLQQFGGHLSVDGKKITVQG
                     PQKLTGQKVVVPGDISSAAFWLVAGLIAPNSRLVLQNVGINETRTGIIDVIRAMGGKL
                     EITEIDPVAKSATLIVESSDLKGTEICGALIPRLIDELPIIALLATQAQDVTVIKDAE
                     ELKVKETDRIQVVADALNSMGADITPTADGMIIKGKSALHGARVNTFGDHRIGMMTAI
                     AALLVAGGEVELDRAEAINTSYPSFFDDLESLIHG"
     gene            complement(17879..18217)
                     /locus_tag="VXE25_000260"
     CDS             complement(17879..18217)
                     /locus_tag="VXE25_000260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000065990.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlbF/YmcA family competence regulator"
                     /protein_id="HEV0770788.1"
                     /translation="MSNIYDSANELSRGLRGLPEYKAVKAAKDAIAADAEASKIFTEY
                     LAFQEEIQKLAQTGQMPDASFQAKMEGFGKQIQGNSLLSEFFTKQQQLAIYLSDIEKI
                     VFEPVSELLK"
     gene            complement(18228..19331)
                     /locus_tag="VXE25_000261"
     CDS             complement(18228..19331)
                     /locus_tag="VXE25_000261"
                     /EC_number="1.3.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prephenate dehydrogenase"
                     /protein_id="HEV0770789.1"
                     /translation="MAKTIYIAGLGLIGASMALGIKRDHPDYEILGYNRSQASRDIAL
                     KEGMIDRATDDFASFAPLADVIILSLPIKQTIAFIKELANLDLREGVIISDAGSTKST
                     IVDAAEQYLAGKSVRFVGAHPMAGSHKTGAASADVNLFENAYYIFTPSSLTSQDTLKE
                     MKDLLSGLHARFIEIDAKEHDRVTSQISHFPHILASSLMEQTAVYAQEHEMARRFAAG
                     GFRDMTRIAESEPGMWTSILLSNSETILDRIEDFKERLEVIGQAISKGDEEQIWNFFN
                     QAREQRQTMEIHKRGGVDSSYDLYVDVPDEEDVILRILELLRGTSLVNIHINEENRED
                     IHGILQISFKNAQDLERAEHLITENTDYTVVIK"
     gene            complement(19341..20507)
                     /gene="aroC"
                     /locus_tag="VXE25_000262"
     CDS             complement(19341..20507)
                     /gene="aroC"
                     /locus_tag="VXE25_000262"
                     /EC_number="4.2.3.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004259785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chorismate synthase"
                     /protein_id="HEV0770790.1"
                     /translation="MRYLTAGESHGPRLTAIIEGIPAGLPLTAEDINEDLRRRQGGYG
                     RGGRMKIESDQVVFTSGVRHGKTTGAPITMDVINKDHQKWLDIMSAEDIEDRLKSKRK
                     ITHPRPGHADLVGGIKYRFDDLRNSLERSSARETTMRVAVGAVAKRLLAELDMEIANH
                     VVVFGGKEIDVPENLTVAEIKQRAAQSEVSIVNQEREQEIKDYIDQIKRDGDTIGGVV
                     ETVVGGVPVGLGSYVQWDRKLDARLAQAVVSINAFKGVEFGLGFEAGYRKGSQVMDEI
                     LWSKEDGYTRRTNNLGGFEGGMTNGQPIVVRGVMKPIPTLYKPLMSVDIETHEPYKAT
                     VERSDPTALPAAGMVMEAVVATVLAQEILEKFSSDNLEELKEAVAKHRDYTKNY"
     gene            complement(20517..21584)
                     /locus_tag="VXE25_000263"
     CDS             complement(20517..21584)
                     /locus_tag="VXE25_000263"
                     /EC_number="4.2.3.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002308136.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-dehydroquinate synthase"
                     /protein_id="HEV0770791.1"
                     /translation="MKIRIDIPHHPYDIQIEKGCMAQAGQWLRELWQPQKVVIVTDNH
                     VASLYAEKVKLSLEDAGFQVAVFDFLEGEERKNLTTVQKVYEFLVKQGLTRSDGIVAL
                     GGGVVGDLAGFVASTYMRGIHFVQIPTSLTAQVDSSIGGKTGVNTPFAKNMVGTFAQP
                     DGVLIDPLVLETLGKRELIEGMGEVIKYGLIEDPELWALLTGLNGSVESILEHAETLI
                     EHSCQVKRKMVVEDELDNGIRLYLNFGHTIGHAIEATAGYGKVMHGEAVAMGMVQISK
                     VAEEKGLMPAGITQSITEMCQKFGLPVDYENWEVDKLYQALTHDKKARGNTLKLVLVP
                     ELGSAIIHPVSLEEMKDYLVK"
     gene            complement(21603..22457)
                     /locus_tag="VXE25_000264"
     CDS             complement(21603..22457)
                     /locus_tag="VXE25_000264"
                     /EC_number="1.1.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate dehydrogenase"
                     /protein_id="HEV0770792.1"
                     /translation="MKLDGYTRLAAVVANPIKHSISPFIHNRAFEATDTNGAYVAWEI
                     EASDLVETVANIRRYQMFGINLSMPYKEQVIPYLDKLSDEARLIGAVNTVVNENGNLI
                     GYNTDGKGFFKCLPSFTISGKKMTLLGAGGAAKSILAQAILDGVSQISVFVRSVSMEK
                     TRPYLDKLQEQTGFKVDLCALEYVSELQARIAESDLLVNATSVGMDGQSSPVPENIVL
                     PETLLVADIIYQPFETPFLKWARSQGNPAVNGLGMLLYQAAEAFQLWTGKEMPTEEIW
                     QSLTEKYQ"
     gene            complement(22447..23124)
                     /locus_tag="VXE25_000265"
     CDS             complement(22447..23124)
                     /locus_tag="VXE25_000265"
                     /EC_number="4.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000780376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I 3-dehydroquinate dehydratase"
                     /protein_id="HEV0770793.1"
                     /translation="MKLIVSVMPRSLEEAQALDATRYLDADIIEWRADYLPKEAILQV
                     APAIFEKFAGRELVFTLRTRSEGGEIDLSPEEYIHLIKEVAQLYQPDYIDFEYYSYKD
                     VFEEMLDFPNLVLSYHNFQETPENMMEILSELTILNPKLVKVAVMAHTEQDVLDLMNY
                     TRGFKTLNPEQEYVTISMGKVGKVSRITADVTGSSWSFASLDEVSAPGQISLASMKKI
                     REILDEA"
     gene            complement(23121..24284)
                     /locus_tag="VXE25_000266"
     CDS             complement(23121..24284)
                     /locus_tag="VXE25_000266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001837533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent rRNA methyltransferase"
                     /protein_id="HEV0770794.1"
                     /translation="MNRIRVSKRVEKKLAKGLVLLEASDLENVNLKDQEVEVQGQEGN
                     FLGTAYLSQQNKGLGWFVSKDKVTFNQTFFETLFRKAKEKRNAYYQDDLTTAFRLFNQ
                     EGDGFGGLTVDLYGDYAVFSWYNSYVYQIRQTISEAFRQVFPEVLGAYEKIRFKGFDY
                     ESAHVYGQEAPDFFTVLENGVLYQVFMNDGLMTGIFLDQHEVRGSLVDGLTMGKSLLN
                     MFSYTAAFSVAAAMGGASQTTSVDLAKRSRELSQAHFQANGLSTDEHRFIVMDVFEYF
                     KYAKRKDLTYDVIVLDPPSFARNKKQTFSVAKDYHKLISQSLEILNPGGIIIASTNAA
                     NVSRQKFTEQIDKGFAGRSYQILNKYGLPADFAYNKKDESSNYLKVISMKVSK"
     gene            complement(24969..26603)
                     /locus_tag="VXE25_000267"
     CDS             complement(24969..26603)
                     /locus_tag="VXE25_000267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001237556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0770795.1"
                     /translation="MRLKVIKKLVDINILYSSQEANLANLRKKQAKNTGKKVNVSARV
                     LSSYIFSSLLMLIFFSTIAIHFPFEEMPVYFSFVVAILLVIAFSTSLTAFYNVFYESK
                     DLASYRPYAFKESEIIIAKGLSVLLPALTGIVPILAYFLALYISLAPSLWLGLPLMLL
                     SLTLLFVSVALVMVVAVHFLAQTTAFRKYQSIFSNVMIGIGVLIPLIFVFFLQSTFGS
                     IVDKVRDIPFLLYPLHIFYKIAVEPFSTEALVGLLAWIGLTLFLLYLTKKKVLPRFYD
                     VILLNSEEKVKKERRSKERISTTKKGFFRMVLRYHLTLLGQGTGVVTVLFTSAFLPYL
                     MMIGLISKIRDSQIVPDIHPPYWLPLFFIALFIAVVNNNITSLHSIALSLERENVDFL
                     KSLPFDFARYVKVKFWIIYAVQSFLPILTLLGLSLYLGLPIISMIYLIMAWILASVIL
                     SCHHYFKDVKNLSINWSSITDLVNRSNGIVAIVLLFIYSAILMALVIGSIFLVQSLST
                     ILAISLGVGALILLLALAIFGYHYYLSRILAEIEKR"
     gene            complement(26584..27333)
                     /locus_tag="VXE25_000268"
     CDS             complement(26584..27333)
                     /locus_tag="VXE25_000268"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000569185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0770796.1"
                     /translation="MIEFQNVSKLYGDKEALSNLNLQIENGEIMGLIGHNGAGKSTTI
                     KSLVSIISPSSGRILVDGQDLSENRLAIKRKIGYVADSPDLFLRLTANEFWELIASSY
                     DLSSSDLEASLARLLNVFDFAENRYQVIETLSHGMRQKVFVIGALLSDLDIWVLDEPL
                     TGLDPQAAFDLKQMMKEHAQKGKTVLFSTHVLEVAEQVCDRIAILKKGHLIYCGKVED
                     LRRDNPDQSLESIYLSLAGRKEEVSDASQGH"
     gene            27512..28966
                     /locus_tag="VXE25_000269"
     CDS             27512..28966
                     /locus_tag="VXE25_000269"
                     /EC_number="3.2.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-amylase"
                     /protein_id="HEV0770797.1"
                     /translation="MQNQTLMQYFEWYLPHDGQHWTRLAENAPHLAHLGISHVWMPPA
                     FKATNEKDVGYGVYDLFDLGEFNQKGTVRTKYGFKEDYLQAIQALKAQGIQPIADVVL
                     NHKAAADHREAFQVIEVDPVDRTVELGEPFTINGWTSFTFDGRQDTYNGFHWHWYHFT
                     GTDYDAKRSKSGIYLIQGDNKGWANEELVDNENGNYDYLMYADLDFKHPEVIQNIYDW
                     ADWFMETTGVAGFRLDAVKHIDSFFMRNFIRDMKEKYGDDFYVFGEFWNPDKEANLDY
                     LEKTEEHFDLVDVRLHQNLFEASQAGANYDLRGIFTDSLVELKPDKAVTFVDNHDTQR
                     GQALESTVEEWFKPAAYALILLRQDGLPCVFYGDYYGISGQYAQEDFKEILDRLLAIR
                     KDLAYGEQNDYFDHANCIGWVRSGAENQSPIAVLISNDQENSKSMFVGQEWTNQTFVD
                     LLGNHQGQVTIDEEGYGQFPVSARSVSVWAVNTI"
     gene            complement(29056..31674)
                     /gene="alaS"
                     /locus_tag="VXE25_000270"
     CDS             complement(29056..31674)
                     /gene="alaS"
                     /locus_tag="VXE25_000270"
                     /EC_number="6.1.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012130635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine--tRNA ligase"
                     /protein_id="HEV0770798.1"
                     /translation="MKQLSSAQVRQMWLDFWATKAHSVEPSVSLVPVNDPTLLWINSG
                     VATLKKYFDGTIIPENPRITNAQKAIRTNDIENVGKTARHHTMFEMLGNFSIGDYFRD
                     EAITWAYELLTSPEWFDFPAEKLYMTYYPDDKDSYNRWIEVGVDSSHLIPIEDNFWEI
                     GAGPSGPDTEIFFDRGEAFDPENIGLRLLAEDIENDRYIEIWNIVLSQFNADPAVPRS
                     EYKELPHKNIDTGAGLERLVAVIQGAKTNFETDLFMPIIREVEKLSGKVYDQDGDNMS
                     FKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRASMHGQKLGINEPFLYKLVPTV
                     GKIMESYYPEVLEKRDFIEKIVKSEEESFARTLHSGQHFAQGIVADLKEKGQSVIAGQ
                     DVFKLYDTYGFPVELTEEIAEEAGMTVDREGFEAAMKEQQERARASAVKGGSMGMQNE
                     TLQNITVESVFNYNTSQLSSKLVAIVADNAEVGAVSEGTASLIFAETSFYAEMGGQVA
                     DYGQILDESGKIVATVTNVQKAPNGQALHTVEVLAPLALNQEYTLAIDSNRRHRVMKN
                     HTATHLLHAALHNILGNHATQAGSLNEVEFLRFDFTHFQAVTAEELRAIEQQVNEKIW
                     EALEVKTVETDIDTAKEMGAMALFGEKYGKEVRVVTIGDYSIELCGGTHVGNTSEIGL
                     FKIVKEEGIGSGTRRILAVTGKEAFEAYREQEDALKAVAATLKAPQVKEVPHKVEGLQ
                     EQLRQLQKENAELKEKAAAAAAGDIFKDAKEVNGHRYIASQVSVSDAGALRTFADNWK
                     QKDYSDLLVLVAAIGDKVNVLVASKTKDLHAGNLVKELAPIIDGRGGGKPDMAMAGGS
                     NQAKIQELLDAVAGKL"
     gene            complement(31696..32181)
                     /locus_tag="VXE25_000271"
     CDS             complement(31696..32181)
                     /locus_tag="VXE25_000271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000847073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LURP-one-related family protein"
                     /protein_id="HEV0770799.1"
                     /translation="MKTFLVKQKFRLGGERFAIKDDRGEIAYQVEGSFFKIPKTFTIY
                     DAAGEQVSEISKEILTLLPRFEIQLRDGSSFVIRKKLTFWRDKYEFDNLGLRIEGNIW
                     DLNFKLLDDRDQLIAEIKKELFHLTSTYTVTVLEDAYADLVISLCVAIDYVEMLESQS
                     H"
     gene            complement(32456..32695)
                     /locus_tag="VXE25_000272"
     CDS             complement(32456..32695)
                     /locus_tag="VXE25_000272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000784186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0770800.1"
                     /translation="MKMSTFFKKSFWPTFMIVNQTVILSHLKDGLDRQYLTTESIYWV
                     IGTFIFGNILVAVFSNMKIWDKKKNGSKKKYILKK"
     gene            complement(32940..34010)
                     /locus_tag="VXE25_000273"
     CDS             complement(32940..34010)
                     /locus_tag="VXE25_000273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HEV0770801.1"
                     /translation="MKKIYSFLAGIAAIILVLWGIATHLDSKINSRDSQKLVIYNWGD
                     YIDPELLTQFTEETGIQVQYETFDSNEAMYTKIKQGGTTYDIAIPSEYMINKMKDEDL
                     LVPLDYSKIEGIENIGPEFLNQSFDPGNKFSIPYFWGTLGIVYNETMVDEAPEHWDDL
                     WKLEYKNSIMLFDGAREVLGLGLNSLGYSLNSKDPQQLEETVDKLYKLTPNIKAIVAD
                     EMKGYMIQNNVAIGVTFSGEASQMLEKNENLRYVVPTEASNLWFDNMVIPKTVKNQDS
                     AYAFINFMLKPENAFQNAEYVGYSTPNLPAKELLPEETKEDKAFYPDVETMKHLEVYE
                     KFDHKWTGKYSDLFLQFKMYRK"
     gene            complement(34007..34780)
                     /locus_tag="VXE25_000274"
     CDS             complement(34007..34780)
                     /locus_tag="VXE25_000274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEV0770802.1"
                     /translation="MKKFANLYLGLVFLVLYLPIFYLIGYAFNAGDDMNSFTGFSWTH
                     FETMFGDGRLMLILAQTFFLAFLSALIATIIGTFGAIYIYQSRKKYQEAFLSLNNILM
                     VAPDVMIGASFLILFTQLKFSLGFLTVLSSHVAFSIPIVVLMVLPRLKEMNGDMIHAA
                     YDLGASQFQMFKEIMLPYLTPSIITGYFMAFTYSLDDFAVTFFVTGNGFSTLSVEIYS
                     RARKGISLEINALSALVFLFSIILVVGYYFISREKEEQA"
     gene            complement(34777..35583)
                     /locus_tag="VXE25_000275"
     CDS             complement(34777..35583)
                     /locus_tag="VXE25_000275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398755.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEV0770803.1"
                     /translation="MKKTSSKLFVVPYMLWIALFVLAPLVLIFGQSFFNIEGQFSLEN
                     YKSYFASQNLTYLKMSFNSVLYAGIVTFVTLLISYPTALFLTRLKHRQLWLMLIILPT
                     WLNLLLKAYAFIGIFGQNGSINQFLEFIGIGSQQLLFTDFSFIFVASYIELPFMILPI
                     FNVLDDMDNNLINASYDLGATKWETFRHVIFPLSMNGVRSGVQSVFIPSLSLFMLTRL
                     IGGNRVITLGTAIEQNFLTNDNYGMGSTIGVILILTMFITMWVTKERRER"
     gene            complement(35564..36721)
                     /locus_tag="VXE25_000276"
     CDS             complement(35564..36721)
                     /locus_tag="VXE25_000276"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018372333.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0770804.1"
                     /translation="MKKPIIEFKNVSKVFEDSNTKVLKDINFELEEGKFYTLLGASGS
                     GKSTILNIIAGLLDATTGDIMLDGVRINDIPTNKRDVHTVFQSYALFPHMNVFENVAF
                     PLRLRKIDKKEIEQRVAEVLKMVQLEGYEKRSIRKLSGGQRQRVAIARAIINQPRVVL
                     LDEPLSALDLKLRTDMQYELRELQQRLGITFVFVTHDQEEALAMSDWIFVMNDGEIVQ
                     SGTPVDIYDEPINHFVATFIGESNILPGTMIEDYLVEFNGKRFEAVDGGMKPNEPVEV
                     VIRPEDLRITLPEEGKLQVKVDTQLFRGVHYEIIAYDELGNEWMIHSTRKAIVGEEIG
                     LDFESEDIHIMRLNETEEEFDARIEEYVEIEEQEAGLINAIEEERDEENKL"
     gene            complement(36881..37786)
                     /gene="murB"
                     /locus_tag="VXE25_000277"
     CDS             complement(36881..37786)
                     /gene="murB"
                     /locus_tag="VXE25_000277"
                     /EC_number="1.3.1.98"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000116193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramate dehydrogenase"
                     /protein_id="HEV0770805.1"
                     /translation="MSVREKMLEILEGIDIRFKEPLHSYSYTKVGGEADYLVFPRNRF
                     ELARVVKFANQENIPWMVLGNASNIIVRDGGIRGFVILCDKLNNVSVDGYTIEAEAGA
                     NLIETTRIALRHSLTGFEFACGIPGSVGGAVFMNAGAYGGEIAHILQSCKVLTKDGEI
                     ETLSAKDLAFGYRHSAIQESGAVVLSVKFALAPGTHQVIKQEMDRLTHLRELKQPLEY
                     PSCGSVFKRPVGHFAGQLISEAGLKGYRIGGVEVSEKHAGFMINVADGTAKDYEDLIQ
                     SVIEKVKEHSGITLEREVRILGESK"
     gene            complement(37898..38650)
                     /locus_tag="VXE25_000278"
     CDS             complement(37898..38650)
                     /locus_tag="VXE25_000278"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000152219.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhfC family intramembrane metalloprotease"
                     /protein_id="HEV0770806.1"
                     /translation="MTIHIIITMLLLLAFLIGSIWFAKKKYQINLAVLGLGAVAFFVS
                     SQILEKLVHILILHPQKDGSIALLQDHPLIYIIYGLAMAAFFEETARLVFFKWLEKKR
                     SLEKADALAYGLGHGGLELIFLGLTSLLNLYIVLSAVQTQNPQVMQLLSENMLKTIQS
                     LSVWQIYLLGFERILALGFQLLLTVWVYQAVRQKKWIYLLAAYGLHAFFDLAPSLFQV
                     GWLTNPVLVEVILALELVLVAYGTKEIFCKKS"
     gene            complement(38660..39391)
                     /gene="budA"
                     /locus_tag="VXE25_000279"
     CDS             complement(38660..39391)
                     /gene="budA"
                     /locus_tag="VXE25_000279"
                     /EC_number="4.1.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000360290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetolactate decarboxylase"
                     /protein_id="HEV0770807.1"
                     /translation="MDKNVQEPVKLFQYNTLGALMAGLYGGTMTVGELLEHGDLGLGT
                     LDSIDGELIVLDGKAYQAKESGDQPEIVEVSPDALIPYAAVVPHQAEVIFRQRFEMTD
                     KELKERIESYYDGENLFRSIKIRGEFSHMHVRMIPKSTPDTKFADIATHQPEYSRDNV
                     AGTIVGFWTPEIFHGVSVAGYHLHFISDDLTFGGHVMDFVIKEGIIEVGAVDQLDQRF
                     PVQDRQYLFAKFNVDEMKKDIEKAE"
     gene            39533..40804
                     /locus_tag="VXE25_000280"
     CDS             39533..40804
                     /locus_tag="VXE25_000280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HEV0770808.1"
                     /translation="MKKQSKYKEVVSYLKNGIESGRFPTGSRLPSIRQLSLDFHCSKD
                     TIQRALLELRHEQYLYAKPQSGYYVLEQGQHQDLEIEVTDEHASAYDDFRLCVNETLI
                     GRENYLFNYYDNQEGLEDLRQSIHKLLFDQALYCKANQLVLTSGTQQALFILSQISFP
                     SQAKEILVEQPTYHRMNRLLIAQGLDYQTIERGIDGIDLEELEGHFKTGKIKFFYTIP
                     RFHYPLGHSYSEQDKRAILDLAAKYSVYIVEDDYLGDLDSKKGQTFHYLDTEERVIYI
                     KSFSTSLFPALRITALILPNTIKEAFVAYKNILDYDSNLIMQKALSLYIDSQLFEKNR
                     LARLTNHESYQKQIEERITKTPCPLPHYPLHDGLLLDLRQYPKIASLKHSQLGLDFFE
                     EAYLSTCPYQFAKVSLDNLENVLNYLKAELE"
     gene            complement(40824..41639)
                     /locus_tag="VXE25_000281"
     CDS             complement(40824..41639)
                     /locus_tag="VXE25_000281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000837371.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HEV0770809.1"
                     /translation="MKSKKWIFVLCNFLASFFLVACQSGSNGSQSAVDAIKQKGKLVV
                     ATSPDYAPFEFQSLVDGKNQVVGADIDMAQAIADELGVKLEILSMSFDNVLTSLQTGK
                     ADLAVAGISATDERKEVFDFSIPYYENKISFLVRKADVEKYKDLTSLESANIAAQKGT
                     VPESMVKEQLPKAQLTSLTNMGEAVNELQAGKIDAVHMDEPVALSYAAKNAGLAVATV
                     SLKMKDGDANAVALRKNSDDLKEVVDKVIQKLKDEGTYQSYLEKAASLTEVEE"
     gene            complement(41796..42449)
                     /gene="phoU"
                     /locus_tag="VXE25_000282"
     CDS             complement(41796..42449)
                     /gene="phoU"
                     /locus_tag="VXE25_000282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000946475.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate signaling complex protein PhoU"
                     /protein_id="HEV0770810.1"
                     /translation="MLRSQFEEDLEKLHNQFYAMGQEVLSQINRTVRAFVTHDRDLAK
                     EVIEDDAEVNEYEVKLEKKSFEMIALQQPVSQDLRTVLTVLKAVSDVERMGDHAVAIA
                     QATIRMKGEERIPAVEEEIKKMGREVKSVVEAALDLYLNGSVDDAYRVASMDEQINHY
                     FETIRDLATEEIKKNPEAIVTGRDYFQVISYLERIGDYAKNICEWVVYFETGKIVEL"
     gene            complement(42461..43219)
                     /gene="pstB"
                     /locus_tag="VXE25_000283"
     CDS             complement(42461..43219)
                     /gene="pstB"
                     /locus_tag="VXE25_000283"
                     /EC_number="7.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014713134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter ATP-binding protein"
                     /protein_id="HEV0770811.1"
                     /translation="MTDAILQVSDLSVYYNKKKALNSVSLSFQPKEITALIGPSGSGK
                     STLLKSLNRMGDLNPEVTTTGSVVYNGHNIYSPRTDTVELRKEIGMVFQQPNPFPMTI
                     YENVVYGLRINGIKDKQVLDEAVEKALQGASIWDEVKDRLYDSAIGLSGGQQQRVCVA
                     RVLATSPKIILLDEPTSALDPISAGKIEETLYGLKDKYTMLLVTRSMQQASRISDKTG
                     FFLDGDLIEFNDTKQMFLDPQHKETEDYITGKFG"
     gene            complement(43232..44035)
                     /gene="pstB"
                     /locus_tag="VXE25_000284"
     CDS             complement(43232..44035)
                     /gene="pstB"
                     /locus_tag="VXE25_000284"
                     /EC_number="7.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000852852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter ATP-binding protein"
                     /protein_id="HEV0770812.1"
                     /translation="MSTYNWDEKHILTFPEEKVALSTKDVHVYYGKNESIKGIDMQFE
                     RNKITALIGPSGSGKSTYLRSLNRMNDTIDIAKVTGQILYRGIDVNRPEINVYEMRKH
                     IGMVFQRPNPFAKSIYRNITFAHERAGVKDKQVLDEIVETSLRQAALWDQVKDDLHKS
                     ALTLSGGQQQRLCIARAISVKPDILLMDEPASALDPIATMQLEETMFELKKNFTIIIV
                     THNMQQAARASDYTGFFYLGDLIEYDKTATIFQNAKLQSTNDYVSGHFG"
     gene            complement(44046..44930)
                     /gene="pstA"
                     /locus_tag="VXE25_000285"
     CDS             complement(44046..44930)
                     /gene="pstA"
                     /locus_tag="VXE25_000285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009443446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease PstA"
                     /protein_id="HEV0770813.1"
                     /translation="MRAKKLDKLATAVLYTIASIIVTILASLILYILVRGLPHISWSF
                     LTGRSSAFQAGGGIGIQLYNSFFLLVITLIISVPLSMGAGIYLAEYAKKGPVTNFVRT
                     CIEILSSLPSVVVGLFGYLIFVVQFEYGFSIISGALALTVFNLPQMTRNVEDSLKHVH
                     HTQREAGLALGISRWETVVHVVIPEALPGIVTGVVLASGRIFGEAAALIYTAGQSAPA
                     LDWSNWNILSVTSPISIFRQAETLAVHIWKVNSEGTIPDGTIVSAGSAAVLLIFILIF
                     NFGARKFGSYLHKKLTAA"
     gene            complement(44920..45837)
                     /gene="pstC"
                     /locus_tag="VXE25_000286"
     CDS             complement(44920..45837)
                     /gene="pstC"
                     /locus_tag="VXE25_000286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018378778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease subunit PstC"
                     /protein_id="HEV0770814.1"
                     /translation="MNQEELAKKMLLPSKNSRLEKLGKGLTFACLSLIVILVAMILVF
                     VAQKGLSTFFVNGVNIFDFLLGGTWNPSSKEFGALPMILGSFIVTILSALIATPFAIG
                     AAVFMTEVSPKGAKILQPAIELLVGIPSVVYGFIGLQVVVPFVRSVFGGTGFGILSGI
                     SVLFVMILPTVTFMTTDSLRAVPRYYREASFAMGATRWQTIWRVILKAARSGIFTAVV
                     FGMARAFGEALAIQMVVGNSAVIPTSLTTPAATLTSILTMGIGNTVMGTVNNNVLWSL
                     ALVLLLMSLVFNSVIKLITKERGKKNYAR"
     gene            complement(45837..46715)
                     /gene="pstS"
                     /locus_tag="VXE25_000287"
     CDS             complement(45837..46715)
                     /gene="pstS"
                     /locus_tag="VXE25_000287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000746338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter substrate-binding
                     protein PstS"
                     /protein_id="HEV0770815.1"
                     /translation="MKKRKKLALSLIAFWLTACLVGCASWIDRGESITAVGSTALQPL
                     VEVAADEFGTIHVGKTVNVQGGGSGTGLSQVQSGAVDIGNSDVFAEEKDGIDASALVD
                     HKVAVAGLALIVNKEVDVDNLTTEQLRQIFIGEVTNWKEVGGKDLPISVINRAAGSGS
                     RATFDTVIMEGQSAMQSQEQDSNGAVKSIVSKSPGAISYLSLTYIDDSVKSMKLNGYD
                     LSPENISSNNWPLWSYEHMYTLGQPNELAAEFLNFVLSDETQEGIVKGLKYIPIKEMK
                     VEKDAAGTVTVLEGRQ"
     gene            complement(47289..48593)
                     /locus_tag="VXE25_000288"
     CDS             complement(47289..48593)
                     /locus_tag="VXE25_000288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160253.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RsmF rRNA methyltransferase first C-terminal
                     domain-containing protein"
                     /protein_id="HEV0770816.1"
                     /translation="MKFPEGFVEKYKEILGDEARDFLASFEEEAVSAFRVNPLKEEQL
                     SFSDAITQTPWGHYGKVSGKSPEHATGLVYSQEPAAQMVAQVAQPSPGMKVLDLAAAP
                     GGKSTQLAAYLAGEGLLVSNEISSKRAKILVENMERFGATNVVVTNESADRLVKVFKG
                     YFDLIVLDAPCSGEGMFRKQPDAMDYWSLDYPSQCASLQREILEDAVTMLAEGGRLVY
                     STCTWAPEENEEIVNWLLEEYDFDLLPVEHINGMVAGIDLPETARMYPHQFKGEGQFV
                     AHLQFKGNNPAPKFKASKSNLSREQVALWQEFAQNHLKVNLPGILQIFGDQLYLLPEL
                     LPDLGKLKIARNGLHLGTFKKKRFEPSFALGLALKPSQVEQSVEIGQEEFVKYAAGET
                     VQLAESLPNGWYQVLVKGNGLGFAKVTGNVLKNYFPKGLRFK"
     gene            complement(48594..49367)
                     /locus_tag="VXE25_000289"
     CDS             complement(48594..49367)
                     /locus_tag="VXE25_000289"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="inositol monophosphatase family protein"
                     /protein_id="HEV0770817.1"
                     /translation="MESKFEFAKELVKKAGQYILDHMQEDLRVETKSSPTDLVTRLDK
                     EVQELLVGEILSRYPEDKICAEEGCLRASVQEGKVWVIDPIDGTNNFVAQQEDFAVMM
                     AYFENGQGQFGLIYDVVKGDCYHGGGEFPVCLNDRPLASFKTKPLGDFLIAGNSGMLE
                     TNEWGLADLSRAVLGVRVYGSAAISFAKILSGRLLTYLTYLQPWDYAAASILGESLGY
                     RVVTLFGEAPDFQTRQPVMMVPLEMQEEIQSYIYERKRT"
     gene            complement(49357..49635)
                     /locus_tag="VXE25_000290"
     CDS             complement(49357..49635)
                     /locus_tag="VXE25_000290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004252549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UPF0223 family protein"
                     /protein_id="HEV0770818.1"
                     /translation="MNKQYSYPLDLSWSTEELASVLSFFNDVEAAYEGKVEAKKLLDS
                     YKGFKAVVPSKSEEKRLGREFETVSGYSLYRAVQAAKEKGEGKISLGK"
     gene            complement(49635..50036)
                     /locus_tag="VXE25_000291"
     CDS             complement(49635..50036)
                     /locus_tag="VXE25_000291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007556665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Spx/MgsR family RNA polymerase-binding
                     regulatory protein"
                     /protein_id="HEV0770819.1"
                     /translation="MITLFLSPSCTSCRKAKAWLEKHKVPFVEHNIMTSPLTRKELQH
                     ILSLTENGTDDIISTRSKIFQKLNIDVESISVSELLHLIEQYPSLLRRPIIIDAKRMQ
                     IGFNEDEIRAFLPRSYRKQELKEARMRAGIS"
     gene            complement(50241..50858)
                     /locus_tag="VXE25_000292"
     CDS             complement(50241..50858)
                     /locus_tag="VXE25_000292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000850480.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01906 family membrane protein"
                     /protein_id="HEV0770820.1"
                     /translation="MKTKLIFWGSMLFLLSLSILLTIYLAWIFYPMEIQWLNLTNRVY
                     LKPETIQYNFHILMNYLTNPFSQVLQMPDFRSSAAGLHHFAVVKNLFHLVQLVALVTL
                     PSFYVFVNRIVKKDFLSLYRKSLLTLVVLPVMIGLGGVLIGFDQFFTLFHQILFVGDD
                     TWLFDPAKDPVIMILPETFFLHAFLLFFALYESFFGYLCLKSRRK"
     gene            complement(50848..51621)
                     /locus_tag="VXE25_000293"
     CDS             complement(50848..51621)
                     /locus_tag="VXE25_000293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01457 family HAD-type hydrolase"
                     /protein_id="HEV0770821.1"
                     /translation="MKYKGYLIDLDGTIYKGKDRIPAGETFVHELQKRDIPYLFVTNN
                     TTRTPESVKEMLAQNFNIDTPLSTVYTATLATIDYMNDLGLEKTVYVVGEAGLKEAIK
                     AAGYVEDKENPAYVVVGLDWQVDYEKFATATLAIQKGAHFIGTNPDLNIPTERGLLPG
                     AGSLITLLEVATRVKPVYIGKPNAIIMDKAVEHLGLEREELIMVGDNYLTDIRAGIDN
                     GIPTLLVTTGFTKAEEVAGLPIAPTHVVSSLAEWDFDEN"
     gene            complement(51632..52369)
                     /locus_tag="VXE25_000294"
     CDS             complement(51632..52369)
                     /locus_tag="VXE25_000294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000524807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-[acyl-carrier-protein] thioesterase"
                     /protein_id="HEV0770822.1"
                     /translation="MGLTYQMKMKIPFDMADMNGHIKLPDVILLSLQVSGMQSIELGV
                     SDKAILEDYNLVWIIAEYDIEVVRLPRFAEEITIETEALSYNRLFCYRRFTIYNEAGQ
                     ELIHMMATFVLMDRDSRKVHAVEPEIVAPYQSDFDKKLIRGPKYESLEEPISKDYHVR
                     FYDLDMNGHVNNSKYLDWIFEVMGADFLTHYIPKKINLKYVKEVRPGGVITSAVERTG
                     LESKHEITSDGVINAQAIITWKEIKKA"
     gene            complement(52374..53504)
                     /locus_tag="VXE25_000295"
     CDS             complement(52374..53504)
                     /locus_tag="VXE25_000295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxygen-independent coproporphyrinogen III
                     oxidase"
                     /protein_id="HEV0770823.1"
                     /translation="MQKKPTSAYVHIPFCTQICYYCDFSKVFIKNQPVDSYLEHLLEE
                     FRSYDIEKLSTLYIGGGTPTALSAPQLEVLLNGLTKNLDLSVLEELTIEANPGDLDAD
                     KIAVLKNSAVNRVSLGVQTFDDKMLKKIGRSHLEKDIYENIDRLKLAGFDNISIDLIY
                     ALPGQTMEQVKENVAKAIGLDIPHMSLYSLILENHTVFMNRMRRGKLPLPKEELEAEM
                     FEYIIAELERAGFEHYEISNFSKPGFESRHNLMYWDNAEYYGIGAGASGYVNGVRYKN
                     HGPIRHYLSAVEEGNACITEDHLSQKEQMEEEMFLGLRKKSGVSMARFEEKFGQSFAG
                     LYGEIVRDLVQQGLMQIEGDHVRMTKRGLFLGDTVAERFILE"
     gene            complement(53588..53977)
                     /locus_tag="VXE25_000296"
     CDS             complement(53588..53977)
                     /locus_tag="VXE25_000296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000517372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YtxH domain-containing protein"
                     /protein_id="HEV0770824.1"
                     /translation="MGKLSSILLGTVSGAALALFLTSDKGKQVCSQAQDFLDDLREDP
                     EYAKEQVCEKLTEVKEQATDFVLKTKEQVESGEITVDSILAQAKSYALQATEASKNQL
                     NNLKEQWQEKAEALDDSEEIVIDITEE"
     gene            complement(53993..54376)
                     /locus_tag="VXE25_000297"
     CDS             complement(53993..54376)
                     /locus_tag="VXE25_000297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF948 domain-containing protein"
                     /protein_id="HEV0770825.1"
                     /translation="MLEVAYILVALALIVFLVYLIITVQKLGRVIDETEKTIKTLTSD
                     VDVTLHHTNELLAKVNVLADDINVKVATIDPLFSAVADLSLSVSDLNDHARVLSKKAS
                     SAGSKTLKTGASLSALRLASKFFKK"
     gene            complement(54377..55165)
                     /locus_tag="VXE25_000298"
     CDS             complement(54377..55165)
                     /locus_tag="VXE25_000298"
                     /EC_number="2.4.99.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prolipoprotein diacylglyceryl transferase"
                     /protein_id="HEV0770826.1"
                     /translation="MLDPIAIQLGPLAIRWYALCIVTGLILAVYLTMKEAPRKKIIPD
                     DILDFILVAFPLAILGARLYYVIFRFDYYSQNLGEIFAIWNGGLAIYGGLITGALVLY
                     IFADRKLINTWDFLDIAAPSVMIAQSLGRWGNFFNQEAYGATVDNLDYLPGFIRDQMY
                     IEGSYRQPTFLYESLWNLLGFALILIFRRKWKSLRRGHITAFYLIWYGFGRMVIEGMR
                     TDSLMFFGLRVSQWLSVVLIGLGIMIVIYQNRKKAPYYITEEEN"
     gene            complement(55158..56093)
                     /locus_tag="VXE25_000299"
     CDS             complement(55158..56093)
                     /locus_tag="VXE25_000299"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399387.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HPr kinase/phosphorylase"
                     /protein_id="HEV0770827.1"
                     /translation="MSVLVKEVIEKLRLDIVYGEPKLLEKEINTADITRPGLEMTGYF
                     DYYTPERIQLLGMKEWSYLISMPSNSRYEVLKKMFLPETPAVIVARGLVVPEEMLKAA
                     RECKIAILTSRAATSRLSGELSSYLDSRLAERTSVHGVLMDIYGMGVLIQGDSGIGKS
                     ETGLELVKRGHRLVADDRVDIFAKDEITLWGEPAEILKHLIEIRGVGIIDVMSLYGAS
                     AVKDSSQVQLAVYLENYDTHKTFDRLGNNAEELEVSGVAIPRIRIPVKTGRNISVVIE
                     AAAMNYRAKEMGFDATRLFDERLTSLIARNEVQNA"
     gene            complement(56223..56399)
                     /locus_tag="VXE25_000300"
     CDS             complement(56223..56399)
                     /locus_tag="VXE25_000300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000048061.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S21"
                     /protein_id="HEV0770828.1"
                     /translation="MSKTVVRKNESLDDALRRFKRAVTKAGTLQETRKREFYEKPSVK
                     RKRKSEVARKRKKF"
     gene            complement(56539..57246)
                     /locus_tag="VXE25_000301"
     CDS             complement(56539..57246)
                     /locus_tag="VXE25_000301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosamine-6-phosphate deaminase"
                     /protein_id="HEV0770829.1"
                     /translation="MKVIKVENQVQGGKVAFEILKEKLANGAQTLGLATGSSPLEFYK
                     EIVESDLDFSNLTSVNLDEYVGLDGDNPQSYRYFMQENLFNQKPFKESFLPRGVKDNA
                     EAEVERYNQILADHPVDLQILGIGRNGHIGFNEPGTPFDSQTHLVELDQSTIEANARF
                     FAKIEDVPTQAISMGIKNILDAKSIILFAYGESKAEAIAGTVSGPVTENLPASSLQNH
                     PDVTIIADAEALSLLEK"
     gene            57397..58425
                     /gene="queA"
                     /locus_tag="VXE25_000302"
     CDS             57397..58425
                     /gene="queA"
                     /locus_tag="VXE25_000302"
                     /EC_number="2.4.99.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA preQ1(34) S-adenosylmethionine
                     ribosyltransferase-isomerase QueA"
                     /protein_id="HEV0770830.1"
                     /translation="MNTADFDFHLPEELIAQTPLEKRDASKLLIVNRETGEMQDKHFH
                     SIINMLEPGDALVMNDTRVLPARLYGQKVETGGHVELLLLKNTSGDEWEVLAKPAKRL
                     KVGTRISFGDGRLSAVVTEELTHGGRIVRFEYQGIFLEVLESLGEMPLPPYIHEKLDD
                     RERYQTVYAKESGSAAAPTAGLHFTKELLAEIQAKGVHLVYLTLHVGLGTFRPVSVDN
                     LDEHEMHSEFYQLSEEAAATLRSVKKNGGRVIAVGTTSIRTLETIGSKFDGQIQADSG
                     WTNIFIKPGYEWKVVDAFSTNFHLPKSTLVMLVSAFAGRELVLDAYHHSIQEHYRFFS
                     FGDAMFIY"
     gene            complement(59086..59271)
                     /locus_tag="VXE25_000303"
     CDS             complement(59086..59271)
                     /locus_tag="VXE25_000303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001837034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase family
                     protein"
                     /protein_id="HEV0770831.1"
                     /translation="MATGWVQVNGSWYYLNSNGSMKVNQWFQVGGKWYYVNASGELAV
                     NTSIDGYRVNDNGEWVR"
     gene            complement(59271..59645)
                     /locus_tag="VXE25_000304"
                     /pseudo
     CDS             complement(59271..59645)
                     /locus_tag="VXE25_000304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846497.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(60376..60927)
                     /locus_tag="VXE25_000305"
     CDS             complement(60376..60927)
                     /locus_tag="VXE25_000305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000835652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0770832.1"
                     /translation="MKSIGTQILQTERLILRRFVESDAEAMFQNWASSAENLTYVTWD
                     PHPDVEITRNSICNWVASYTNLNYYKWAICLKENPEQVIGDISIVKIDEADLSCEIGY
                     VLGKAYWGNGMMTETLKAILDFCFTQAGFQKVRARYASLNPASGRVMEKAGMSYLQTI
                     VNGVERKGYLADLIYYGISREEC"
     gene            complement(61277..62101)
                     /gene="nadE"
                     /locus_tag="VXE25_000306"
     CDS             complement(61277..62101)
                     /gene="nadE"
                     /locus_tag="VXE25_000306"
                     /EC_number="6.3.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000058066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ammonia-dependent NAD(+) synthetase"
                     /protein_id="HEV0770833.1"
                     /translation="MSLQETIIQELGVKPVIDAQEEIRRSIDFLKRYLKKHPFLKTFV
                     LGISGGQDSTLAGRLAQLAMEELRAETGDDSYKFIAVRLPYGVQADEADAQKALAFIQ
                     PDVSLVVNIKESADTMTAAVEATGSPVSDFNKGNIKARCRMIAQYALAGSHSGAVIGT
                     DHAAENITGFFTKFGDGGADILPLYRLNKRQGKQLLQELGADPALYEKIPTADLEEDK
                     PGLADEVALGVTYAEIDDYLEGKTISPEAQATIENWWHKGQHKRHLPITVFDDFWE"
     gene            complement(62098..63558)
                     /locus_tag="VXE25_000307"
     CDS             complement(62098..63558)
                     /locus_tag="VXE25_000307"
                     /EC_number="6.3.4.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinate phosphoribosyltransferase"
                     /protein_id="HEV0770834.1"
                     /translation="MYPDDSLTLHTDLYQINMMQVYFDQGIHNKKAVFEVYFRQQPFK
                     NGYAVFAGLERIVNYLEDLRFSDSDIAYLESLGYHGAFLDYLRNFKLELTVRSAQEGD
                     LVFANEPIVQVEGPLAQCQLVETALLNIVNYQTLVATKAARIRSVIEDEPLMEFGTRR
                     AQEMDAAIWGTRAAVIGGANGTSNVRAGKLFDIPVLGTHAHALVQVYGNDYEAFKAYA
                     ATHKNCVFLVDTYDTLRIGVPAAIQVARELGDQINFMGVRIDSGDIAYISKKVRQQLD
                     EAGFTEAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYDQPALGAVYKIVAIE
                     DETGQMRNTIKLSNNAEKVSTPGKKQVWRITSREKGKSEGDYITYDGVDISDMTEIKM
                     FHPTYTYIKKTVRNFDAVPLLVDIFKEGILVYNLPSLTDIQDYARKEFDKLWDEYKRV
                     LNPQHYPVDLARDVWQDKMDLIDKMRKEALGEGEEE"
     gene            complement(63674..64162)
                     /locus_tag="VXE25_000308"
     CDS             complement(63674..64162)
                     /locus_tag="VXE25_000308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000797183.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0770835.1"
                     /translation="MKNRFYYYQLLDEREEQLFNKAGSESFYICIALSLLSYIISVLA
                     PSLFNSNMLLIVIIIGTFYFFNRARYLGVTYYSRFHFTILGCFFLTLAITALLMLQNY
                     QFNIEIYQHNPLNFKYLSAGVITYVIYLPWVFIGNLGLKSYGEWAQKKFEQDMDELES
                     GE"
     gene            complement(64152..64361)
                     /locus_tag="VXE25_000309"
     CDS             complement(64152..64361)
                     /locus_tag="VXE25_000309"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013670190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEV0770836.1"
                     /translation="MAKNLKLKLARVERDLTQGQLAEAVGVTRQTIGLIEAGKYNPSL
                     SLCQSICRCLGKTLDQLFWEEEDEK"
     gene            complement(64747..65475)
                     /locus_tag="VXE25_000310"
     CDS             complement(64747..65475)
                     /locus_tag="VXE25_000310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000773447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEV0770837.1"
                     /translation="MKLNKLNFLKENIRNLYSSGVIYLSLLISFIPPILLTFFILKTQ
                     GTSLGIKHISNFYAMLGMLMAVIHANRVISRDFSHNTVSLFYNQQKNRMIYVLSNFLY
                     AISVSIIYALNGIVLLVIVSKLGIPGDLGLDFIVAIVVNTILLVLFYFLLSYIFYLYK
                     LKSGLGFGILVALLLFIPNILNTMMMNTSNDLFIKAIELLPFYSLPVFVASNTMSISQ
                     YLVVITTIILLYFFTLKKSKKYSF"
     gene            complement(65491..66282)
                     /locus_tag="VXE25_000311"
     CDS             complement(65491..66282)
                     /locus_tag="VXE25_000311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0770838.1"
                     /translation="MNFALNKGEIVGLAGRNGVGKSTLMKILVQNNQPTSGNIISSDN
                     VGYLIEEPKLFLSKTGLENLKYLSNLYGVDYNQEIFRSLIQELDLTQSINKKVKTYSL
                     GTKQKLALLLTLVTEPDILILDEPTNGLDIESSQIVLAVLKNLALHENVGILISSHKL
                     EDIEEICERVLFLENGLLTFQKVGKDSHNFLFEIAFSSATDRDIFITKQEFGDIVQEE
                     GLRITMSGNIQSSEFFKFFNENSIKVVDFETKKETLKDIYLNRSK"
BASE COUNT        19956 a        15050 c        12413 g        19388 t
ORIGIN      
        1 tgttttgagc tgacttcgtc agtcttatct acaacctcaa agctgtgctt tgagcaacct
       61 acggctagct tcctagtttg ctctttgatt ttcattgagt attacagtga acaatttttc
      121 tagctattgt aacaaaaaag tcactcgaag gcaacttttt tcgtccataa actttcaaaa
      181 gagaatggct tattcagaac taaaagccgc agctttttgc atttggtaat acttaccctt
      241 tctatccatg agttcttgat ggttaccata ttcaacaata tcaccatcta ctaagacaag
      301 aattaaatcc gcatcctgaa tggttgacaa acggtgagca atgatgaagc ttgtgcggcc
      361 cttcatgagt tttgcaaagg catcctgtac cagcacttct gtccgtgtat caatggaaga
      421 agttgcctcg tctaagataa gaatctttgg aatagccaga aagactcggg ctatggtcaa
      481 gagctgagct tggccgacag agagagattc tccagcattt tccaacttgg tatcgtatcc
      541 ctgtggcaac tgttggatga aaaagtctgc attagctgct ttggcagcag caattacttg
      601 ctctcgactg gcttcaggat tgccaaaggc aatattatca tgaatggtcc cttgtgtgag
      661 ccaggtttct tgaagcacca taccaaactg ctgtctcaat gatactcgtg tataatcata
      721 aatggattgc ccatccagca agatatctcc cgagctaatg ggataaaaac gcataaggag
      781 attgataaga gtcgattttc cagcacctgt cggaccaacg atggctacct tactaccagc
      841 tggaatatcg atagacaagt ccttaatcaa aattttttca ggatggtagc caaaagagac
      901 atgtttaaag gaaatagctc ccttaacttg gtcactggtc aagacttcct tacctgtttc
      961 agccacttca gggctatcta agactccata gatacgctct acgcaagcca gagcactttg
     1021 caactcagct agcactgaag aaatatcgtt aaagggcttg gtgtattgct gaacatagtt
     1081 caaaaaagtc actaaacgac cgacggtcaa ggttgaaccc atcatgatac gataagctcc
     1141 tactccagct aaaagggcat aaatgagtgc atttacaaag cgagtcgaag gattgaccgt
     1201 tgaagaataa aagatggctg actgagaata gcctgagtag ttgtcatgag cctcacgcaa
     1261 tctttggata aactctgttt gagcattgaa ggactggatt atagtctgct ggctaagcga
     1321 ttcttcaatc aaatgggtct gaatccccct cgtctctgtt tgcttctgga agagatgata
     1381 ggatctcttg gcaataaagc gtgaaatcac catggacagt ggcgtcaaca gcaagactaa
     1441 gagagtcatg aggagatgaa tttggagcat ggctagaata ctaaccaaaa tcatcaaaac
     1501 accaatgaaa aattggttaa aaatcatggt caagccagct gccaactgtt cgatgtccgt
     1561 ggttacacga ctgaccatct ctccattgcc ttgccgatcc gcaaaagcaa tcggtaaccg
     1621 atggagttta tggatgattc gctctcgtaa atctctggta taagagaaga ttagacgatt
     1681 atagaggaga ggattggccc attgtaccag agtatttcct attaccacca agagcatctg
     1741 gagaaaaatc tgccaaaaaa ttggtgatga accagccact aggacttggt caatgacctg
     1801 cccaatcaga ataggtaggt aaattgataa gccaacttgg gcaatagttc ctagaaaagc
     1861 taggaaaagg aggaagggat ggtttgctaa atctacggct aaacgtttga gcgtctggtt
     1921 tacagtttgt cgtttcattc tagtcctcct ttccatgttg ggatgcattg atttcacgat
     1981 agacttggct ggatttcatc aagtcatcgt gcttgccaac agctagcaac tcaccttttt
     2041 ccaagaggag aatctggtcc gccatctgta aagttgaggt tcgttgagag atcaaaatta
     2101 agctcgtgtt tggaaaattt tctctaatag ctttcaagag cttggactct gtaatggtat
     2161 ctagtgccga ggttgcatca tctaggatga gaaacggagc ttggcgcaag actgctcggg
     2221 cgatagacaa cctttgtttt tgtccacctg agaaatttcg cccccctgct tcaactagag
     2281 catccaagag tccttcctta tcactgacaa aatccttagc ttgagcaatt tccaaggcct
     2341 gccagagttc ttgatcagtc acttcttgat tgaaacctag agtcaagttg gaacgaatgg
     2401 ttcctttaaa gagttcgacc ttttgaggta cagaggcaat ccaagaccgc cactgctcca
     2461 aattaagagg actacgtcca ttttgataaa ggtcaatgtt ccccttgtct actggataaa
     2521 gtccaagtaa gagttgcacc aagcttgatt taccagaacc agtcccccca atgataccaa
     2581 ggatttgtcc ttgagtcata tcaaaggaaa tgtctctcag agaaggctgg gccgcatcag
     2641 gataggtaaa ggtcaattct tggacttgta aaacccgatc actggtaact tgcttttgtt
     2701 ctaattctga atggatatcc tctggagcct caacaaagac ttccttgatt cgcttggctg
     2761 agatatagga ccggttgaga gaattgatca acatggctag cttgaccaat tccaccaaaa
     2821 tctgtaagag gtaattgata agagcaatga gagcaccttg actgagcact cctccttgaa
     2881 ttgaaatata gccttgccag ataataacga gaagagttcc attgacaatc agataggtca
     2941 gaggtgttaa taaactagac cagaaacctg tcttttcttg taatctagca taaacttggt
     3001 taagggtttg aaaaatctgt aactctcgtt tttcttgacc aaaagcacga ataacccgca
     3061 tcccttgcaa ttgctggcgc gtttcctgaa ccagttggtc cgttttcttt ctgagactac
     3121 tgtagagagg attgaccaat cgcgataacc ctacaatgac aatggtcaaa atggcaacca
     3181 tgactaagaa ccagaaagtc aactcagctg agattcgata agccataaaa atggcaccaa
     3241 aaacgataat gggcgctcgt aaaaagagac gcaggaattg attgatacca gtctgaatct
     3301 ggtaggtatc cgaagtcaag cgagtgacca aactagaagt tgtcagacgg tctctgctgt
     3361 ccttgggcaa ggaaagaata tgacgataaa gatcgtttgt caattcctta gcaaaaccta
     3421 ctgctgcctt tgctgagtaa aattgagcta tcaaggccac taaaacgcca attactgcaa
     3481 agataaggag cagaccaatc tgcatccaga gatgaccttg atctccctga ggtaaagatt
     3541 ggtcaacaat cccagcaatc accatgggaa ccaagagctc aaaaacagct tctaacagct
     3601 tgaacaaggg ggctaaaatt gattccttga tgtagggttt gaagtaagat aataggtgtt
     3661 tcataaatcc cttttattca tattctagaa atgaagaaag tgggaaaccc caccctctct
     3721 gttttatttg tttaagtaag gcaatagata gccatatcct gctttttcca tctcatcctt
     3781 ggccacaaag cgtaaagaag cagaattgat acagtaacgg aggccgccta actcccgcgg
     3841 tccatctgtg aaaacatgac ccaagtgagc gctgcctgaa cgagaacgaa cttcaattcg
     3901 ctccattcca tggctcagat ccttgtaata atgaatcaac tctttggaaa tcggacggct
     3961 aaaacttggc caaccacaac ctgaagcaaa cttatccttg gcaaaaaaga gtggctcacc
     4021 tgtcgtaata tctacataaa tcccctcttc aaaggtttgg tcataggcat tggtaaatgg
     4081 agcctctgta gcagcttctt gtgtgacacg ataagactct tcagatagac tggccttcaa
     4141 cacctcttga ctaggctttt catagtttgc tgcatcaatc aatggcttat cagcatcggt
     4201 cacatcgata tgacagtaac ctgaaggatt cttcctgaga tagtcttggt ggtagtcttc
     4261 agccagaatg tagtggcgta attgctccac ttctactgca atctttcgac ccagcatgcg
     4321 ttcctgctcc tgcaccactg tgtagatagc tggcaaatct gcttcatcct gataataaat
     4381 cccagttcga tattggcgac cacggtcatt cccttgttga ttgatagata gaggatcgat
     4441 aactcggaaa taataaagta aaatctctct gagtgacact tccttctcat cgtaaatcac
     4501 ttggaccgtt tctgcatggt ctgtttcctt gagcaactgg taattggtcg tttcgacttg
     4561 accattagcg tagccaacac tggtttctag cactccagaa atgcgtgaaa aatattcctc
     4621 taggccccaa aaacaaccac ctgctagata aatttctgcc atctttattt ctcctttatc
     4681 acgtttttaa ctaatactct tcgaaaatct cttcaaacca cgttagcgtc accttaccgt
     4741 atatatgtta ctgacttcgt cagttctatc tgcaacctca aaacagtgtc ttgagctgac
     4801 ttcgtcagtt ctatccacaa cctcaaaaca ctgttttgag cagcctgcgg ctagcttcct
     4861 agtttgctct ttgattttca ttgagtataa acttcttttc acaaaaagga tatgaaaccc
     4921 tctggtcaag agtttcccca tcctatcttc tattctttat tttgcttcta cacggacacc
     4981 ttgggtatca actctcaagt catgcagttt tcctttgaaa ggttgctttt ccaattctgc
     5041 cttaattgtt ggcatcttgt catgagaagc cagaaccata actgtcggcc cagcaccaga
     5101 aaggtaggtt gcataggctc cattttcttt ggtcacttgc ttaatcatcg caaattctct
     5161 taccaagtcc tgacgatagc gctcatggaa gaggtctccc tcgattgctt gcccagcggt
     5221 caccatgtct cctgccaaca aggcagcaac cgctacattg gcgatagaac ttgcagcaac
     5281 agcttcctta taagacaatt ttttaggcaa gacactacgg ctgtcgcgag tacgtaattc
     5341 atagtttgga atgtaagcta gaaaatcaca ctctggaaag tctgctacga tagcagagac
     5401 ttgcccttca acagaacttg caataacgag attaccataa atggctggag ccacattgtc
     5461 aggatgccct tcaatcttgg tcgctaactg caatttttca tggtctgata agttgagttg
     5521 acccagttgg ttggctagtt caatcccagc aacgataacc gagctggaag aacccaaacc
     5581 gcgcgccaaa gggacatcac tggtcatttt caagcgtctt ggttgcaagt ctggtacaat
     5641 ttgtaaagcg attttgagca agagattacg ctcatcatgt ggaatccatt tgccaatctg
     5701 gtgttcaatc agccactcat ctcgttcttc gcagacctca atttgaagat acttggttac
     5761 agctacaccg accgagtcaa aacctggccc gatattggca ctggttgcag gtacaataat
     5821 cttcatctta ttctcctagc accttgaagg tattcaagag gtcgaattct gaaaccttct
     5881 tcaattcagc tgagacattt tcaagctggg ctttattaat cttgtgtgtg atgataacga
     5941 cacgcgcctt gtcaccctct ttgccatctt gaaggatttg cttaaaggaa atatcttgag
     6001 cattgaagat ttcagccaac ttcaagacct gaccttttga gtctagagcc aagattgaga
     6061 aatagtagtt tgctttgaca tcttcaggat ttgccaagac caagtcacgg ctatattcgt
     6121 tgaagtcttt gccaatagta ccatcattca aacgacgaac gatacggaca atatcagcta
     6181 caacacttgt tgcagttggt ttttgacccg cacctggtcc gtagtacata gactcaccaa
     6241 taccgataga ttctacaaag acagcgttca ttacgccatt cacactagca agtgggtgcg
     6301 ctttaggtag gaaggttgga gtcacttctg cagcaatacc tgaagaagtt tcctcaatag
     6361 aaccaaccaa tttcactacg taaccaagct cttgagctac agctacgtct tctggtgtga
     6421 tattgcggat tcccttgtgg gctacatcat caaaggcgat cttcatgcca aaggcaaatt
     6481 ggctcaaaat aaccatcttg taggctgcat caatcccatc tacgtcattc gtcggatcgc
     6541 tttctgcaaa tcctagacgt tgtgcttccg caagagcatc atcgtaagac cagccttctt
     6601 ccaccatctt ggtcaccatg aagttggaag ttccgttgac tactccaagc acgcgcgtaa
     6661 ttttatcaga agccaaggaa tttgctaaag tacgaagaat tggaatccca ccagcaactg
     6721 ctgcttcgta gtaaagtgct accttgttag cttgagcgat ttctagcaat tctgcgccat
     6781 ggacagctaa aaggtccttg ttagcagtaa caacgtgttt tccagcttcc aaggcacgag
     6841 tgataaaggt tttagcaggc tcaatacgcc ccatcaattc cactacgata gtaatatcct
     6901 ggtctgataa aatatcatcc acattggtta caaagttaaa gtcattccct gctgcaagca
     6961 agcgattttt ttcatcttca tccttgacca ataccttagc aactttgata tctgaatgtg
     7021 ctgattgatt gatttttcct ccattttcct ttaggaggaa aggcacacca cttgcaacgg
     7081 taccaaatcc cagtaaagca attttaactg tcatctttat ctcctcgaaa ttttctaata
     7141 tagccattat aacagaattt tgtgaaaatt cctattatag taaatcacta tttcagtata
     7201 aaaagaaaaa acgaatcaga cgattcgctc ttcttaaaat ctgaaaatag ctttccagaa
     7261 aggattagcc gattttttgc agattgagca ctgcatcgtg actcatcaag acttgaccat
     7321 actcttgtaa gactgagcga ctgatatcac tatcgtctgc aaactcgcgc atacgggcca
     7381 acagccaagc tggatatggg cttggatgat tttcaatatc cactaaaatg gtcaaataat
     7441 agcgctcgtt cattttgtag agttcagaag tttccatttc aaaagtcact gtcttggcaa
     7501 aaactaccaa gtcagccaac ttagcaaaag aaaggatgta gtagatgtaa ggttctttct
     7561 tactctcagc ttcttgttca gcctgctctt gctcttcttc cttggcttca acttgctcaa
     7621 gagattgaat ggcttcgata tcatccttgg ttttgtctgc gatgcttttt tccagggttt
     7681 tgataaattc atctggagac atttgagcca attcttccat atctggcaaa tccgataagt
     7741 cttcaaaatc tagattttgg tcaatctttg acttggtcac aaagacatct accttatcag
     7801 gttttggagt cacacggaag ctcaacatgc ctgtatccag aaagctatca ggcatctcta
     7861 gctcatccaa gatagcataa aagaactctt ctgttttttc ttgaggaacg agaaagtcag
     7921 caatctccat tccacgatcc atcaaatcct ctaaagacat cgtgattttt aaagttgtat
     7981 cactaatttg tttcattttc attgctagta acctcatact ttcagttcta tctattatac
     8041 tagattttta cgattttatc aaaagaaggc tcctctatac ggatagattt tccctagggt
     8101 ctttctatag gagactccaa gagaaaattt ctgcagacag atagaaaaag ccttcaaaat
     8161 cggctaagag ccgattttga agaccttata catcagaata cttataattt aaaggttgct
     8221 acaccgagga tagaacgatt taagtttctg agaatttgaa gactttgctc aaatttctta
     8281 taacgagtca ctccgtactc ttcaacaaga aggactgtat ctctttccaa aagagatgat
     8341 acatcctgta aatctacaaa atgcattcct tttaaagctt cttgactctg tttcaattta
     8401 tctaggatag ctttatttga gctaacgatg gtcaattcct gtccagtatt tttgtatgac
     8461 aaaacatctg ctaggttagc aattgttgta atctctgtta caaaatcaat ttgatactga
     8521 gaaaaatcac ctactctatt gattgttgga ttaaagagat aaactaacac atttcccatc
     8581 acaaccaaaa tcacacaaac cactccaata acaactaaac gaagaatcag atttttcaca
     8641 tttaagccaa gcgctgtttc accatttgcg ttcaattctt tagagttgat ggtttccagt
     8701 ttttcaattt ttacatttgc ataggcatgt ttaaatttct caatcaaccc atcaattttt
     8761 ttctctaaca agtcattggc atctttactt gatgtcaaaa ttttcacacc aacccctgca
     8821 tcgtcaatca tatagtagac ggtcaatttt ttccaccaat agtcattcgt tgaatttttc
     8881 aaggttgttt ctgtcgtgtc taattcactg gcaatttttt tcaactcact gggttctaca
     8941 tcattgaaaa gataagctcc attcaaatta ccatcaatca atttcccata aaaatcacta
     9001 taaccaccaa tttgatgatt caaaatcgtt ttggccgaat cttctggagg agtgatttta
     9061 tagataagat aagttgaata acttgttgta tctttgacag tgtttttatt cctaactgct
     9121 ttaattgtaa atggtacagc aatgagagca aataaagcga tgagagctaa aatatttgct
     9181 tttcgttttt tataaagatt tgcaaacaaa tcagctactg aataatgttc aaacatgatt
     9241 tttttctcct ttgtttagta gatactagtt ttcctttgta agcatttttg ctacaaatat
     9301 aatcacaaga acaattcccc agaattgcat tgtaaataaa ttgaagaaac tttctgaaaa
     9361 gctgcttctt ggcataaaga atagattatt caagatgagt agggataaag caaataggat
     9421 tgtccttgag cgataggcta cttgcagcat ggctataaat aatatgccga gtaagaaact
     9481 aagcagaaag actccaatca taccatagtc ggtatacaac tccatgatat aactacttcc
     9541 gataccatgc cctttcaagt attccttgtt caagacaaga taggatagat tgtgggcata
     9601 actattacta tcaatagcta gttccacact attggttgta tgttcaaagg cttttcctcc
     9661 gaaaatggct cccaaactcc cccttgcaaa ataatcaaga acaggaccaa aagtaaaatt
     9721 acggaaatct cggtaaggga ggctactgtt aaatagaaaa cctcgagcca gaacaccaaa
     9781 actagtccct tgtttataga taaagtcaag taagatatcc cagaaacctg tatgggaaac
     9841 ttggacatta tcccgtacat aattgagtac tcccatcgct aacatgagaa taggagaacc
     9901 tacaaaaatc gctaactttt ctttaaaccc aatccatttt cctttttcag cttgctcccg
     9961 cataaagtaa taaacaaaag caaataaaat acttaaaata aagggatttc gtgtcccaat
    10021 tgccaaatga atagtgttag ctgcaataaa ggagacaagc actgctgtgg cctgcaattt
    10081 ctttggcttg gttgccagat acatacacat tgcatagacc gtaaaggtag acaaaatgta
    10141 ggtaaaataa ggcagtttac tttcaaaatt tgcatagtag gcatagtagg aagtctgcaa
    10201 acgatacaag agccgttcaa ataaccgaat gaaatagaaa ggataagtta gaagaaaaac
    10261 tcctagtgat acaaagcgta accgcttgat ataaacctct tttagagaat ttcctatatt
    10321 tgctactttt attttcttcc tagctatgaa gtaacgagcc aggacgcctc ctgttgtcaa
    10381 gcccagaatc gaaaccatga caactataaa ggcaaaacga taggctattg gatgataggt
    10441 atccaaagca ccatccctaa aataatcaat ggtcggtctt gataccagaa atacaaaaat
    10501 ggttaaatag aaaataaaat ggattaagta atacttgata tcattccaac aagcaatcaa
    10561 gctactaacc aacaagaaca ataaagtaga aagtaagcta acattattat tattaaacag
    10621 atacacaatt ccacttacta gcgtcaaggc ataactgact atggtcaaac taaataataa
    10681 tcgtttccca tcaatcactt ggtcaccccc gttctaatgt aattttttag atttttcaat
    10741 atttttcagt aataagaatc ggtataagga aatatttatg aatagggcca aagcactaat
    10801 tcttctcccc ttacggaaaa ttgaattcct agaaatagca aaggcatggc cttttaaaaa
    10861 acgatgaatc tgagaatagg cttcaaactg tttatactga tcatctagca acatcttatc
    10921 cagaataaag aagtgggcat aggccaatct gaaaaaagcg acctctttca agtcaggata
    10981 gtttttcaca acttcattat aaaacttttg gtagatatca atataggcta aatccttctc
    11041 tgcatagggc ttggtcgtaa tactatcccc tctatggaaa tagtaataat agggtttagt
    11101 attaaccaca tacttcttgg ccaacttgat taaatcaaaa tggtaatagg catcttcgta
    11161 aatcaacccc ttaggaaagg ataggtcagt tgcaatctgt ctcttgatta gcttattgca
    11221 aatcgtccca ggtatttttt cacctatgag gtattccttt agaaatgttt gagaatcaca
    11281 gacaaaatag tcatcctgat tggctgactg tgggctttca tcattagcat agacattcat
    11341 gacaccacag ctcgaaacat ccgcatcttc ttgaactaat tgctcatata agctctgaat
    11401 catttctgga tggatataat catctgagtc aataaaaatc agataatccc cgtgagcctg
    11461 cttcatccca tcatttcgtg cttgcgacaa tccttcgttc tttttatgaa gcactgacac
    11521 cctgtcatct tgttcagcga ttgaatcaca caagcgacca ctttcatctg ttgcaccatc
    11581 atcaacaaga ataatttcca gattttgata ggtctgcttc tgaatggaag ctatcgattt
    11641 ttctaggtac tgcgccacat tatagactgg cacaatcaca ctaattaatg cagtttccat
    11701 gctactcctc taatagtttt tctacttgtt cgatttgttt tgtaattgta aattgttgaa
    11761 tgaattggct agcctcatcg acatcaaagt ttgaggcaga agtcatgtaa ttagtaatcg
    11821 cctgagctgc ctcttgattg ctctcaatga tttgtccaaa tcgtccttct tgggataatt
    11881 cctcagcccc tccaacgtcc gtagagataa aagggagtcc cagactcaag gcctccacat
    11941 acactccagg aaaaccttct tgtttagaca tagacaagag aactttcgtc tgagatagat
    12001 actgataagg atttttttga taaccaagga aatgtacata gtcctcaatc ccatactctt
    12061 tgactcgttt tttcagttcc tcttccatat caccagcccc gataaaatag agatgatagt
    12121 tttttccctc ttggtataat aatcgtatca cttccactac acggtcagaa cccttatttt
    12181 cctcaatccg tccgatagta cagatacttt gaggagcaat ctcgatatcg atcttctctt
    12241 gagatttttc tagaatagtc tgaaaatcat atccattgta gattgtctgt aatttagaag
    12301 cataatctgg ataaacttcc ttgatagaat tgctggtctt ttttgaaatc cctacaattg
    12361 tattcgcagc atccaactgg cttctatgtg attctctttt agagctatcc ttaagaagtt
    12421 cttcaatact tccatgaatc caagatatct tcttgacttc tcttctttta gagaacaaca
    12481 gtggtggatt cataatggta aaagaaactt caacatcata atcatctttt acaagcaaac
    12541 gacgagtcag tcttggaaaa taaattctca ttctccacaa aaaagctcgt aaccatctgg
    12601 tttggcgata atcttgaagg gattttaaaa tgcgtacatg ctttggaaca gattcatatc
    12661 ccttgtcaaa gtgctccatt tcaagaatat caatatcata cttttctgga tccagatttg
    12721 aaacaatagt tgatagaatc ttctctgcac cacctccaag agaaaaagac cacataaaaa
    12781 ataagatttt tttcttagcc accatattct cccttgtatt ctgtataaga cttatccata
    12841 tcagcgatga cagcatcatg atgcggtacc tgcttgtctg ctggtggagg cgtcatataa
    12901 tccccaaaag cagttctgag atagacatca tagccgattg gaataggcat ctctgttcct
    12961 tcaaatggca agaaaagatt gtcttcaaaa gatgtgattg ggtacttgtt tctcatgtag
    13021 ccaggacctg agcataattc tgtaatgcca tcacaatcag ccaaatcata cttagtcatt
    13081 tctttctcag cttttttcca gatgcgataa cggagagatt ttggagtcaa acccagtaaa
    13141 atgcaacttc cccatttcat gagagcacca tgcttttctg gaatagtttg cgcacaaaag
    13201 agtgaataaa tcaaggccca acgaacctgt tttttccgct cagctggatt tttcggataa
    13261 taatccaaag gcaaaacatc caaggccaga ccatgtggca aatccaaatc ctgctgataa
    13321 ggcttgatac aggtggtttt cttgtcacga atggtaataa aaagattacg atcaacaaaa
    13381 tccttgtgac tctttgacaa gaaataacgt tcatctgcat aacgaggcca taattctgct
    13441 aatttctcat aatctttacg aggcataaaa aagtctaggt cgtcgtccca aggaataaat
    13501 cccttgtttc gaagggcacc aatagcgcct ccgccacaga gataacagag caaatcatgt
    13561 tctttacaaa aggccacaaa atattcagcc atctccagac tacgagcctg aattgctttt
    13621 aaatcagtca tattgttcat tattctttct atcgtatcgt ttcattatac cacaaacaag
    13681 gggtgaaaat ctattgcaga ctgtaaaaaa tcaaagcctg actgctatcc aaatagctat
    13741 caaactttga tttttctgtc ttatactctt cgaaaatctc ttcaaaccac gtcagcttca
    13801 ccttgccgta ggtataggta actgacttcg tcagtcttat ctacaacctc aaaactgtgt
    13861 ttttagcagc ctgcggctag cttcctagtt tgcactttga ttttcattga gtattatctt
    13921 atctcaagcc catttgagcg agcttggttt gatatttgtt ttgatcaacc agcaagccca
    13981 agcctccata aacatcatag gcatctaccc agtcacccag ttctggaatc gtcaattttt
    14041 caataccatt ttttgctcca tccaaaacag ataaaccgtt tgttaggagg aaagtataag
    14101 gtacgttggt tgaggtcata gcaaaaacct ttccaagagc ttcagaacca gtgaaaagtt
    14161 tagtgggatc tttaatttgc tctaaaattg ctgttaaaac ttgttgctgt ctttttgtac
    14221 ggccgtaatc cgcctcatca tcatcacgga aacgagcata attgagcagg gtcgagccat
    14281 tcatctgctg ttttccgact ttaatggttt gggttggaga ctcagtctcg gtagcatata
    14341 aatcatctcc gactgtagct tctgttaggg gacgcccatt caatgttgaa aattgagcat
    14401 caatcgtcac cccatcaggg aaaagcgtgt caatcgctgt ggcaaaggcc tggaaatcaa
    14461 ccaaggcgta gtacttaatg tccaagtcaa aattatcttt caagacttgg cgaaccattt
    14521 ctgccccttt ttgcccctct tgttctccta actcgtaggc tacgtttaac ttgttatctg
    14581 tctgttttct accattaatc acttgactat aaccatctat atagaccaaa ttatcacgca
    14641 tgaaactgac tagcttcatt ttcttatctg agcccccgac atttaatacc ataatagagt
    14701 cagttcgtgt ctcaacactg ttctggccga ttcgaccatc agtacccatg attaaaatat
    14761 taactccatc tctagtgtcc tgaccattaa agacttctac ttgagctgcc cgggcatcag
    14821 cagttttctt tgcgctagca tcttggtaac cacgcaaaaa catgaatacc atggccaaag
    14881 ccacacagac caaaagtgaa aaaatcacca taaaaattcg tttaagacgg agcttccgtc
    14941 ttttcttttt tggagggaaa gagagtgctt gtgatttgga ttgtgagcga ctccggttcg
    15001 catagcttgg taagtcaacc tgctcttctc tttcttgttc caagctagag ctactatttc
    15061 ccctagcaag agttagcttt tcttgcaaat aggcaaactc atttttttct ctctcattga
    15121 gatagtgaat attttttagc aaataatcat aacgcaactg ctcatgatga cttaagggat
    15181 tttctttact catcttctct cctttccatg gtctgatatt ggataaatag gataggcacc
    15241 cagaatttta tactggattc caatcgcttc taattctttt tgggcaaagt ggaccaagtc
    15301 cttatcggta taatccacat cgataatgaa aaagtattca cccagtgctg tcttgagtgg
    15361 acgactttca atttttgtca agtcaattcc tcgccaagca aaggtcgaca gggccttata
    15421 aagtgcacct ggaaggttgt caggtaatgt caaggccaaa ctcatctttt cagtttgtgc
    15481 ttgcaaggga atactaggct tttcagctcc tagaacccag aaacgtgtga aattggcttc
    15541 catttcctga atatcctcgg caatcagttc caatccatat tcttcagcag aacttctagg
    15601 tgcaactgct gcaaagggct ggtctggatg ttcggaaata aaacgggccg cataagctgt
    15661 actagctgtt acctcgattt gagcctctgg atattgttca tcgatgaatt tctttccttg
    15721 agccaaggcc tgtggatgtg aaaaaatctt ttcaatctta gtatggcctg gaaccaccat
    15781 caactgctga tgaataggct gaacgatttc tgctactgct tggatgtgag cctgatgaaa
    15841 aagatagtcc aaggtttcat gaacactacc ctcaatagaa ttttcaactg gcaccacaga
    15901 atagtccact aatccttgct cataagcctt gatgacatct gtaatgttgg caaaagcctg
    15961 caattcctca tgaggaaaag ctgtctgcac aacgtggtgt gaaaatgatc ctttgggacc
    16021 tagataagca attttcatct tagttcctct ataatttcct ctgggcttag cttggtcaca
    16081 tccaaaaccc gactagccac ttcctcatac caagcctgtc tttcttgaaa aatagctact
    16141 agttcttcct tgctattatt tagaaaaagc ggtcgctgat tgtccttatc agctgcgata
    16201 cgttggtaga gggtttcaaa atctgctttc aggtagatgt tatctgtatt agtcttgagt
    16261 aagtcacgat ttctctgaga aataaccact cctcctccag ttgacacgac ttggtctgtt
    16321 tgtagtaaat cagctaggac ttctgattct acctgacgaa aggctgcttc tcccttttca
    16381 gcgaaaaaat tcgcaatgga catacctagg cgcttctcaa tcagagcatc catatcaagg
    16441 taattagggt ccaagcctct tgcaatagtc gattttccag cccccataaa ccctaataac
    16501 accttagcca tgaatcaagc tctccaaatc atcaaagaaa ctaggatagc tggtattgat
    16561 ggcttctgca cggtcaagct ccacctctcc acctgcaacc aatagggctg cgatagctgt
    16621 catcatgccg atacggtggt caccaaacgt attgactcta gcaccgtgaa gagctgattt
    16681 tcctttgata atcatcccat ctgccgtagg agtaatatct gctcccatac tatttaaggc
    16741 gtctgccaca acctgaatac ggtctgtttc cttgaccttg agctcctcag catccttgat
    16801 aactgttaca tcttgggctt gggtcgcaag tagggcaata ataggcaatt catcaatcaa
    16861 acgtggaatc aaagcgccac aaatctctgt tcctttcaag tcagaagact caacaatcaa
    16921 ggttgcagat ttagcgactg gatcgatttc agttatttcc aattttccac ccatggcacg
    16981 aatgacatca ataataccgg tgcgagtttc gttgatcccc acattctgca gcactagacg
    17041 agaatttgga gcaatcaaac ctgcgactaa ccaaaaggct gcactggaaa tatctcctgg
    17101 tacgaccacc ttctgtcctg tcaatttttg tggcccttgg actgtgattt tcttaccgtc
    17161 cacacttaaa tgaccaccaa attgttgcaa catatcttca gtatgattac gggtgtactc
    17221 tttttcgata ataactgact cccccttagc ttgtaaggct gcaaacatca aggctgactt
    17281 gacttgggca gaggcaattg gcaactcata atgaataggt cttaggtttt tcgtcccttt
    17341 taagcgaagg ggaggcaagt ctcgttcagt ttgtcctgaa atgctgacgc ccattttttt
    17401 cagtggaagg gtcacacggt ccataggacg tttggaaaga ctatcatctc caaacatctc
    17461 tacttcgaaa tctgcaccag caaggacacc tgaaatcagg cgaatcgagg tgccagaatt
    17521 tcccatatta agggcatttt gcggcgcttt taagccagcc atgcctacac cttgaatggt
    17581 aataacccca tctttatcct caatttcaac accaaggtca cgaaaaacct gcatggtcga
    17641 aagaacgtct tcacctcgca gaatatcata aaccttggtc tcaccctcag ccaaacttcc
    17701 aaagataatg gaacggtggc tgatagactt gtcacctggg acgcggatac taccatgtaa
    17761 atggcgaatg tttgttttta gtttcatact ggacctcata cttgcaatac ttttacctat
    17821 tttatcataa aaagccagaa attccttaaa aattcctgac tttaggatag ttcttttctt
    17881 atttcagcaa ttctgaaact ggttcaaaaa caattttttc aatgtcagaa aggtaaatgg
    17941 ccaattgttg ttgcttggta aagaattctg acaagaggct atttccttga atctgtttac
    18001 caaagccttc catcttagct tggaaggacg catctggcat ttgacctgtc tgtgctagtt
    18061 tttgaatttc ctcttgaaag gcaagatatt ctgtaaagat tttgcttgcc tcagcatctg
    18121 ctgcaatcgc atctttagct gctttaacag ccttgtattc tggtaatccg cgtagaccgc
    18181 gactgagttc gtttgcacta tcgtaaatat ttgacatgtt cttctcctta tttgatgacg
    18241 actgtatagt cggtattttc tgttatgaga tgctcagctc tttccaagtc ttgagcattt
    18301 ttaaatgaaa tttgtaggat tccgtgaata tcctcacgat tttcctcgtt gatgtggatg
    18361 ttaaccaagg aagttccacg tagcagttcc aaaatccgca ggatgacatc ttcttcatca
    18421 ggaacgtcaa catagaggtc gtaagagcta tccacaccac cacgcttatg gatttccatg
    18481 gtctggcgtt gttcacgcgc ttggttaaaa aagttccaaa tttgctcttc atctccctta
    18541 ctaatggcct gaccaatcac ttccaaacgt tccttgaaat cctcaattct atccagaatg
    18601 gtctcgctat tggacaagag aatggaggtc cacattcctg gctcgctttc cgcaattcgg
    18661 gtcatatctc gaaaaccacc tgccgcaaag cgccttgcca tctcatgctc ttgagcatag
    18721 accgcagtct gctccatgag actagaagcc aaaatatgag ggaaatggct aatctgagaa
    18781 gtgacacgat catgctcctt ggcatcaatc tcgataaaac gagcatgaag acctgaaagc
    18841 agatccttca tttccttaag cgtgtcctga cttgtcaggc ttgaaggtgt aaagatataa
    18901 taggcatttt caaaaagatt gacatctgcc gaagcagccc ctgtcttgtg actaccagcc
    18961 atgggatggg ccccgacaaa gcgaacagac ttgccagcca aatactgctc cgccgcatcc
    19021 acaatggttg acttggtcga accagcatct gaaataataa cgccttctcg caaatccaaa
    19081 ttggccaact ccttaatgaa agcaatagtt tgtttgattg gcaagctgag gataatgaca
    19141 tctgccaaag gagcaaaact agcaaaatca tccgttgcac ggtcaatcat accttctttc
    19201 aaggcgatat ctctcgaagc ttgactacga ttataaccta aaatttcata atctggatga
    19261 tcgcgtttga taccaagtgc catagaggct ccaatcaacc caagacctgc gatatagatt
    19321 gtttttgcca taggaactcc ttaatagttc tttgtatagt ctcggtgttt ggctaccgct
    19381 tcttttagtt cctcaagatt atctgatgag aatttttcga ggatttcttg cgccagaacc
    19441 gttgctacaa ctgcttccat gaccattcct gcagctggaa gagcagtcgg atcacttctc
    19501 tccacggttg ccttgtaagg ttcgtgggtt tcgatatcca cactcataag aggtttataa
    19561 agagtaggaa tgggtttcat gaccccacga acaacgatgg gttgcccatt agtcatacca
    19621 ccttcaaaac cacctagatt attggtacgg cgagtataac cgtcttcttt agaccagaga
    19681 atttcatcca taacttggct gcctttacga taaccagcct caaagccaag accaaattcc
    19741 acccctttaa aggcattgat agagacaaca gcttgagcca atcttgcatc caattttcta
    19801 tcccattgga cataggaacc aagaccaact ggaacgcctc cgacgactgt ctccacaacc
    19861 ccaccgatgg tatcaccatc acgtttgatt tggtcaatat agtccttgat ttcctgttct
    19921 cgttcttggt tgacaataga aacttcagac tgggcagctc tttgcttaat ttcagcgact
    19981 gtcagatttt caggaacatc tatttcctta ccaccaaaga ccacgacatg gttggcaatc
    20041 tccatatcca gctcagccaa gaggcgtttg gctactgcac caactgccac ccgcatggtg
    20101 gtttcacgag ctgatgaacg ctccaaagaa tttcgcaaat catcaaaacg gtacttaatc
    20161 cccccaacca aatcggcatg acctgggcga ggatgagtaa ttttccgctt gcttttaagg
    20221 cggtcttcaa tgtcctccgc agacatgatg tccagccatt tctggtggtc cttattgatg
    20281 acatccatag taataggcgc ccctgtcgtc ttcccgtggc gaacgcccga agtaaagaca
    20341 acctggtcac tctcaatctt catacgacca ccacgaccgt agccaccctg acggcgtcta
    20401 aggtcctcat tgatatcctc agctgtcaat ggaagtccag ctgggattcc ctcaataata
    20461 gctgttagac gggggccgtg tgattctcct gcagttaaat atctcataca ctctccttat
    20521 tttaccaagt agtctttcat ctcttccaga gaaactgggt gaatgatcgc tgaaccaagc
    20581 tctggcacca agaccaattt caaggtgtta ccacgcgctt tcttgtcatg agtaagagcc
    20641 tgataaagct tgtcaacttc ccaattttca tagtcaacag gcaagccgaa tttctgacac
    20701 atctctgtga tagattgggt aatgccagct ggcatgaggc ctttttcctc agcaaccttg
    20761 gaaatctgta ccattcccat ggcaacagcc tctccatgca tgaccttgcc ataaccggca
    20821 gtcgcttcga tggcatggcc aatagtgtgg ccaaaattga ggtaaagacg aataccattg
    20881 tccaactcat cttcaaccac catcttgcgc ttcacctgac aagaatgttc aatcaaggtc
    20941 tctgcatgtt ccaaaatact ctcaacagaa ccattcagtc ccgtcaagag agcccacagt
    21001 tctggatcct caatcaagcc atacttgata acttcaccca tcccttcaat caactctctt
    21061 tttccgaggg tttcaagaac aagtggatca atcagaaccc catctggttg ggcaaaggtc
    21121 cccaccatat ttttagcaaa tggtgtgtta acgcctgtct ttccaccgat agaagaatca
    21181 acctgagctg tcaaactagt cggaatctga acaaagtgaa taccccgcat ataggtagag
    21241 gctacaaagc cagccaggtc cccaacaacg ccaccaccaa gagcaacgat tccatcgcta
    21301 cgagtcagac cttgcttgac tagaaattca tagactttct gaacagtagt taaattcttt
    21361 ctttcttcac cttctaagaa atcaaaaaca gctacctgaa aaccagcatc ttctaggctg
    21421 agcttgacct tctctgcata gagagaggct acatggttat ctgtcacaat gactaccttt
    21481 tgcggttgcc agagttctcg caaccactga ccagcctggg ccatacaacc tttttcaatc
    21541 tgaatatcat aaggatgatg aggaatatcg attctgattt tcataggaga gtctcccttt
    21601 ctttattggt atttttctgt taaagactgc caaatctctt ctgtcggcat ttccttgcct
    21661 gtccacagtt gaaaagcttc tgcagcttga tagagtaaca ttcccagacc attgactgct
    21721 ggattgccct gacttctagc ccatttcaaa aacggtgttt caaagggttg gtatatgata
    21781 tctgcaacta agagagtttc tggtaagact atgttttcag gaacaggaga ggattggcca
    21841 tccatgccca cactggtggc attaactagc aaatccgact cggcaatcct tgcttgcagt
    21901 tcagaaacat attctaaagc acacaaatcc actttaaagc ctgtctgctc ctgtaacttg
    21961 tctaggtaag gtcttgtttt ttccatagaa acggaacgaa caaagaccga aatctgactg
    22021 acgccatcca aaatagcctg tgccaagatt gatttagccg caccacctgc acccagcagg
    22081 gtcatctttt tacctgaaat tgtaaaagaa ggcaagcact taaaaaatcc cttgccatct
    22141 gtattatatc caattaaatt gccattctca ttgacaaccg tattaaccgc accaatcaag
    22201 cgcgcttcat cgctcagctt atccaaataa ggaatcacct gctccttata gggcatggac
    22261 agattgatgc caaacatctg gtagcgacga atattggcca ctgtttctac caagtcactc
    22321 gcttcaatct cccaagccac ataagcaccg ttggtatctg tcgcctcaaa ggctctattg
    22381 tggatgaagg gagaaataga atgcttaata ggattggcaa caactgcagc taaacgtgta
    22441 tagccatcaa gcttcatcca aaatctccct gatttttttc atgctagcta gagaaatctg
    22501 cccaggggca ctaacctcat ccagactggc aaaagaccaa ctcgaaccag tcacatccgc
    22561 agtgatacga gagaccttgc ccaccttacc catagaaatg gtcacatatt cctgttcagg
    22621 attgagggtt ttaaagcctc gtgtatagtt catcaagtct aagacatcct gctccgtgtg
    22681 agccatcacc gcaaccttaa caagttttgg atttaggatc gtcaactctg acaagatttc
    22741 catcatgttc tcaggtgttt cttggaaatt atggtaactc aaaacaagat ttgggaagtc
    22801 cagcatttcc tcaaaaacat ccttgtagct atagtactca aaatcaatat agtctggttg
    22861 atagagttgc gcaacttcct tgattagatg gatatactct tctggagaaa ggtcgatttc
    22921 tccaccttcg gagcgagttc gtagcgtgaa aaccaactca cggcctgcga atttttcaaa
    22981 aatggctgga gctacctgca aaatcgcttc tttaggcaga tagtcggcac gccattcaat
    23041 gatgtcggca tccagatacc tcgtggcatc cagagcctga gcctcctcta aacttcttgg
    23101 cattactgaa acgattaatt tcatttacta accttcatac taatcacctt gaggtaatta
    23161 ctactttcat cttttttatt ataggcaaaa tctgctggaa gaccatattt gtttaaaatc
    23221 tggtaacttc ttcctgcaaa acctttatca atttgttctg taaatttctg gcgggaaaca
    23281 ttggcagcat tggtactggc aatgataatc cctcccggat ttaaaatctc aagactctgg
    23341 gaaatcaact tgtgataatc cttggccaca gagaaagttt gttttttatt ccgagcaaag
    23401 ctaggcggat ctaggacaat cacatcgtag gtcaagtctt tgcgtttggc atatttgaaa
    23461 tactcaaaga catccatgac tataaaacga tgctcgtctg tgctgagccc atttgcctga
    23521 aaatgcgctt gagacaattc tcgtgaacgt ttggctagat caacagaagt tgtctggcta
    23581 gctcctccca tggccgcagc tactgaaaaa gccgctgtgt aggaaaacat attgagcaag
    23641 gatttaccca tagtcaagcc gtcaactaaa ctaccgcgaa cctcatgctg gtctaggaaa
    23701 attcctgtca tcaagccatc attcataaag acttgataca ggacaccatt ttctaaaaca
    23761 gtgaaaaagt caggtgcttc ttgaccataa acatgggcag attcatagtc aaaaccctta
    23821 aagcggattt tctcataagc ccctaaaacc tcagggaaaa cctgtctaaa ggcttctgat
    23881 atagtctgac gaatctgata aacataagag ttataccaag aaaagacggc gtagtcgcca
    23941 taaaggtcca ctgtcagacc cccaaagcca tctccctctt gattaaagag acgaaaggca
    24001 gttgtcaaat catcttgata gtaggcgttt ctcttttctt tggcttttct aaacaacgtt
    24061 tcaaagaaag tttgattgaa ggtcaccttg tctttgctga caaaccagcc caagcccttg
    24121 ttttgctgag aaaggtaggc agtcccaaga aagtttcctt cctgaccctg cacctctact
    24181 tcctgatcct taagattgac attctcaaga tcactggctt ctagtaaaac tagcccctta
    24241 gcaagcttct tttcaaccct tttgctgact cttattctat tcataactac cattatatca
    24301 aacttttaga caattctcaa aaaagaaact acccttgctt ttttactctt cttttaaaaa
    24361 atggtatact agacttcctg caaaactagg aagtaaatgt gtaagaatca caataaaaaa
    24421 tgctcttccg tcttggagga gcatttttta ttatcaacga aaatcaaata gcaaactatg
    24481 aaactagcct caggttaact gtgagattat aggtagagag gttgtatcag caatatgtgt
    24541 ctgtcaaatt tagtgacaaa ggtagtagaa gaaagatgaa gaaataaatc agcttcagta
    24601 gatatctgga aaatttgatt ttatagagaa gccttttgtt acaaactcaa tatactatca
    24661 ataaataata ttatagaagc aacaataatt ataatttcac ctatttgcat cattctattt
    24721 cgaactctaa atatatgttc tatcaaaaat acttggatca cacacattat aggaattaac
    24781 gtttttgaaa ttgaaaaata tcccaataaa taaactataa acaacaaaaa tagaactatg
    24841 ttatatttct tattcaaaac attcctccct atatttttga ttaccaatct taatcattta
    24901 caactacatt ctaacaaact ataaaagcgt ttgtcgaatt gaatttatca agcaagcgac
    24961 caaccagctc atcttttttc tatttctgcc aatatgcgtg acaggtaata atgatagcca
    25021 aaaatagcaa gagcaagcag gaggataaga gctcctactc ccaagctgat ggcaaggata
    25081 gtggagagag actgaaccaa gaatatgctc ccaattacaa gggccatcag gattgcacta
    25141 taaataaaca ataaaactat ggcgactatg ccatttgaac gattcaccag gtccgtaatg
    25201 ctactccaat tgattgacag atttttaacg tccttaaagt aatggtggca agaaaggatg
    25261 acactggcaa ggatccatgc cataataagg taaatcatcg aaatgatggg caagcctaga
    25321 tatagagaaa gaccaagtaa agtcagaatt ggtaaaaagg actggacggc atatataatc
    25381 caaaatttca ctttcacata acgagcaaag tcaaagggta aactcttcag aaaatcaaca
    25441 ttttccctct ccaaggacaa ggcaattgaa tgcaggctgg tgatattgtt attgacaact
    25501 gctataaaga gagctataaa aaacaagggt aaccagtatg gaggatgaat gtctggaact
    25561 atctgagaat ctcggatttt ggaaatcaga ccgatcatca tgagataagg aaggaaagca
    25621 cttgtaaaaa gcactgtaac cacgccagta ccctgtccca agagggtgag gtggtagcgt
    25681 aaaaccatgc ggaaaaatcc ctttttagtg gttgaaattc tctccttgct gcgacgttct
    25741 tttttgacct tctcctcact attaagcagg atcacgtcat aaaaacgagg aaggaccttc
    25801 tttttggtca gataaagcag gaagagagtt agtcctatcc aagcgagcag acccactaag
    25861 gcttctgtcg aaaaaggctc cactgctatt ttgtaaaaga tatgaagagg ataaaggaga
    25921 aatggaatgt ctctaacttt gtcaacaata cttccaaaag tcgactgtag aaagaagaca
    25981 aatattaaag gtatgagaac tcctatccca atcatcacat tcgaaaaaat agactgatac
    26041 tttctgaagg ccgtagtttg agccaagaaa tgcactgcca ctaccatcac tagagccaca
    26101 gagacaaata ataaggtcaa ggacagtagc atcaaaggca aacccagcca aagagaagga
    26161 gctagactaa tatagagggc tagaaaataa gctaggattg gtacaattcc agttagagct
    26221 ggcaaaagga cagacagtcc tttagcaatt ataatctctg attctttaaa ggcatagggc
    26281 ctataggagg ccaggtcctt actctcataa aagacattgt aaaatgcagt taaagaagtt
    26341 gaaaaggcaa tcactagtaa aatagcaacc acaaaactaa aataaacagg catttcctca
    26401 aaaggaaaat gaatggctat agtactaaaa aagatgagca tcaagagact ggaaaaaatg
    26461 taagaactta ggactctagc ggaaacattt actttttttc cagtattttt agcttgcttc
    26521 tttcgtaggt tagccagatt agcttcttga gatgaataga ggatattgat atcaactaat
    26581 tttttaatga ccttgagacg catctgaaac ctcctctttt ctaccagcaa ggctaaggta
    26641 gatactttcc aaagactggt ctgggttgtc tcttctcaag tcctctacct taccacaata
    26701 aatcaaatgc ccctttttca aaatagcaat ccgatcacag acttgctcag ctacctctag
    26761 gacatgagtt gaaaacaaaa ctgtcttacc tttttgcgca tgctccttca tcatttgctt
    26821 caaatcaaag gcagcctggg gatccaaacc agtcaagggt tcgtccaaga cccaaatatc
    26881 aagatcagac aagagtgccc cgatgacaaa aactttctga cgcattccat gagaaagggt
    26941 ttcaataacc tgataacgat tttcagcaaa atcaaaaacg ttcaataacc tagctaaact
    27001 agcttccaag tcagagctgc tcaaatcata ggatgaagca atcaattccc aaaattcatt
    27061 ggccgttaaa cgtaaaaata agtcaggcga gtctgctacg tagccaatct ttcgtttgat
    27121 cgccaagcga ttttccgata aatcctgacc atctaccaaa atacgaccac tgctgggtga
    27181 aatgatactg actagggatt ttatggtggt cgattttcca gccccattat gaccaatcaa
    27241 gcccataatc tctccatttt caatctgcaa attgagatta ctcaaggcct ctttatcacc
    27301 atacaactta ctaacatttt gaaattcaat catgggacaa ctcctatctt tatctgtatt
    27361 atacatcgct atactagcac tttgatacaa aaaaatcaat actttatttt aagtagttaa
    27421 aatagtttcc ttctatctta cgcaaacgtt tgcgctaata gatactttat gatagaataa
    27481 agaacaagat tgacaagtaa gaggaaacat catgcaaaat caaacactca tgcaatactt
    27541 tgaatggtat ctgccccacg acggtcaaca ctggacgcgt ctggctgaaa atgctccaca
    27601 cctagctcat ctggggatca gtcacgtctg gatgccacca gcttttaagg caaccaatga
    27661 aaaagatgta ggttatgggg tctatgactt atttgaccta ggagagttca accaaaaagg
    27721 gactgtccgc accaagtatg gtttcaaaga agactatctt caagccattc aagcccttaa
    27781 agcgcaggga attcaaccaa tagccgatgt agttctcaac cacaaggctg ctgccgatca
    27841 cagggaagcc tttcaggtta ttgaagtgga tcctgtagac cgtacagttg aacttggaga
    27901 acccttcacc atcaatggct ggactagttt taccttcgat ggtcgccaag atacctataa
    27961 tggcttccac tggcattggt accacttcac cggtacagac tacgatgcca aacgcagtaa
    28021 atctgggatt tatctgatcc aaggggacaa caagggctgg gctaacgagg aattggtcga
    28081 taacgaaaac ggaaactacg actacctcat gtatgccgac ctagacttta aacatcctga
    28141 agtcatccaa aacatctatg actgggctga ttggttcatg gaaacgactg gtgtagctgg
    28201 tttccgtttg gatgccgtta agcatattga ctctttcttt atgcgcaact tcatccgcga
    28261 tatgaaggaa aaatacggtg acgatttcta tgtttttggt gaattttgga acccagacaa
    28321 ggaagccaat ctggactatc tcgaaaaaac ggaagaacac tttgaccttg tcgatgttcg
    28381 tctccaccag aatctctttg aagccagtca agctggcgca aactatgacc ttcgtggcat
    28441 ttttacagat agcctggttg aactcaagcc tgacaaggct gtgacttttg tcgacaacca
    28501 cgatacccaa cgaggacaag cccttgagtc taccgttgaa gaatggttca agccagcagc
    28561 ctatgccctc attttgttac gccaagacgg ccttccatgt gtcttttacg gagactacta
    28621 tgggatttca ggccagtatg ctcaagaaga tttcaaagaa atccttgacc gcctcctagc
    28681 catccgaaaa gacttggcct atggagaaca aaatgactac tttgaccatg ctaactgtat
    28741 cggttgggta cgttcaggtg ctgaaaatca atccccaatc gcagtcctta tctcaaatga
    28801 ccaagaaaac agcaagtcaa tgtttgtcgg tcaagaatgg actaatcaaa cctttgtaga
    28861 tttacttggt aaccaccaag gtcaagttac aattgatgag gaaggttatg gacaattccc
    28921 tgtctcagct agatccgtaa gtgtctgggc agtcaatacc atctaatagc tcataataac
    28981 caagctaggt ccaagcggat ttggcttttt tgtattcaca aaaagaccta cccaaatgga
    29041 tagatcttta cttgattaca atttacctgc tactgcatcc aacaattctt ggatcttagc
    29101 ttggttgctt cctcctgcca tggccatgtc tggtttacca ccaccacgtc catcgatgat
    29161 tggtgctaat tctttgacaa ggtttcctgc atgaaggtct tttgtcttgc ttgctacaag
    29221 gacattgact ttgtcaccga tagcggcaac taggacaaga agatcagagt agtctttttg
    29281 tttccagtta tctgcaaaag tacgaagggc accggcatcg gatacagaca cttgactagc
    29341 aatgtaacga tgaccgttga cttccttagc atctttgaag atatcgcctg cggctgcagc
    29401 tgcggctttt tctttcaact cagcattttc tttttgaagt tgacgaagtt gttcttgaag
    29461 tccttctacc ttgtgaggta cttccttgac ttgaggtgct ttcaaggttg ctgcgacagc
    29521 tttaagagca tcctcttgtt cacgataggc ttcaaaggct tccttaccag tcactgccaa
    29581 gatacggcga gttcctgaac cgattccttc ttctttgaca attttgaaga gaccaatctc
    29641 agaagtgttg ccaacatgag taccaccaca aagttcaata gagtagtcac cgatagtcac
    29701 gacacgaact tccttgccgt atttctcacc aaagagggcc atagctccca tttctttagc
    29761 agtgtcaata tctgtttcaa ctgtcttcac ttcaagtgct tcccaaattt tctcgttaac
    29821 ttgctgttca atcgcacgaa gttcctcagc agttactgct tggaagtggg taaagtcaaa
    29881 gcgaaggaat tcaacttcgt taagagatcc tgcctgtgtt gcgtggtttc caaggatatt
    29941 gtgaagggca gcgtgaagca aatgagtcgc agtgtggttt ttcatgacac ggtgacggcg
    30001 attgctatca attgccaagg tatattcttg gttcaaggca agcggtgcaa ggacttcaac
    30061 tgtatgaagg gcttgaccat ttggggcttt ctgaacattg gtcacagtag ccacaatctt
    30121 acctgactca tccaagattt gtccgtagtc agctacctgt ccacccattt cagcataaaa
    30181 tgacgtttcc gcaaagataa gagaggcagt tccttctgaa acagctccta cttctgcatt
    30241 gtcagcaacg atagctacca atttagaaga caattggcta gtattgtagt tgaagacact
    30301 ttctacagtg atgttttgaa gagtttcatt ttgcataccc attgagccac ccttgacagc
    30361 tgacgcacgc gcgcgttctt gctgttcttt catggctgct tcaaaacctt cacggtctac
    30421 agtcatacca gcttcttcag caatttcttc agtcaattca actgggaatc cgtatgtatc
    30481 atagagttta aagacatctt gaccagcaat gacagattga cctttttctt tcaagtctgc
    30541 cacaatgcct tgggcaaagt gttgacctga gtgaagggta cgggcaaatg attcttcttc
    30601 gctcttaacg attttctcaa taaagtcacg tttctcaagc acttctgggt agtagctttc
    30661 catgattttt ccaacagttg gaacaagttt gtaaaggaaa ggctcgttga tacccaattt
    30721 ttgaccatgc atagaagcac gacggagaag acgacgaaga acataaccac gaccttcatt
    30781 tcctggaagg gcaccatcac cgatagcaaa tgaaagagaa cgaatgtggt ctgcgataac
    30841 cttgaagctc atgttgtcgc catcttggtc ataaacctta ccagacaatt tctcgacttc
    30901 acggataatc ggcatgaaga ggtccgtttc aaagttggtc ttagcccctt ggataacagc
    30961 caccaaacgc tccaaaccag cgcccgtatc aatgttctta tgtggcaatt ccttgtattc
    31021 gctacgagga acagcagggt ctgcgttaaa ttgtgacaaa acgatgttcc agatttcaat
    31081 ataacggtcg ttttcaatat cttctgcaag caggcgaaga ccgatatttt ctgggtcaaa
    31141 ggcttcccca cggtcaaaga agatttctgt atctggtcca gaaggtcccg caccgatttc
    31201 ccagaagttg tcctcaattg gaatcaagtg acttgaatcc actcccactt caatccagcg
    31261 gttgtaagaa tctttatcgt ctggatagta ggtcatgtaa agtttttcag cagggaaatc
    31321 aaaccattca gggcttgtca aaagctcata agcccaagtg atagcttcgt cacggaagta
    31381 atccccgata gagaagttcc ccagcatttc aaacatggta tggtgacgcg cagtcttccc
    31441 tacgttttcg atgtcgttgg tacggatagc cttttgggca ttggtaatac gtggattttc
    31501 agggataatg gtcccgtcaa agtatttctt aagggttgct accccagagt tgatccacaa
    31561 aagagttggg tcatttacag gaaccaaact tactgatggt tctactgagt gagctttggt
    31621 cgcccagaaa tcaagccaca tttggcgtac ttgtgcacta gatagttgtt tcatattgtc
    31681 tccttattta cttgtttaat gtgattggct ttccagcatt tccacatagt caatcgcgac
    31741 acagagggaa atgactaggt ctgcataagc gtcctcaaga accgttacgg tataggtaga
    31801 ggtcagatgg aagagttcct tcttaatttc cgcaatcagc tgatcgcgat catccagcaa
    31861 tttgaaattc aaatcccaga tattgccctc gatacgaaga cctagattat caaactcata
    31921 cttatctcgc cagaaggtca acttcttacg aatgacaaaa ctcgagccat cccgaagctg
    31981 aatctcaaaa cgaggaagca aggtcaagat ttctttacta atctcactga cttgttcacc
    32041 agccgcatca tagatggtaa aggttttagg aatcttaaaa aatgatccct ccacctgata
    32101 ggcaatttct cccctgtcat ccttgatagc gaagcgttcg cctccaagac gaaacttttg
    32161 tttgacaaga aatgttttca tcaacacctc caaaaatcaa aagacaagct catatcacga
    32221 agggcgaaaa accgcggtac caccttcatt caatgaactt gtcattctct tgttcttatg
    32281 caattgtatg attgagtagc atgacttcct agcttagatg gctcgcagca ccgccatttc
    32341 tctggactaa gacaagtgaa aatcaattct caactttctt attataacgt ttttttaagc
    32401 ttgcgtcaac tggaaatgat ctccgttgaa ttagaccaat tccctacatc tctgattact
    32461 ttttcaggat atattttttc ttactgccgt ttttcttttt atcccaaatt ttcatattac
    32521 taaacacagc tactagaata tttccaaata taaaggtgcc tatcacccaa tatatggact
    32581 cagttgttag gtattgtcga tccaagccat cctttaaatg ggatagtata acagtttggt
    32641 taacaatcat aaaggttggc cagaaacttt ttttgaaaaa agtagacatt ttcattattt
    32701 gttgccgctt tctgtaaggt taatactcaa taaaaatcaa aaagcaaact aggaagctag
    32761 cctcaagctg tacttgagta cggcaaggca acgctgacgt ggtttgaaga atataggctt
    32821 agtatactac taggcaagca aataagcaac tagaatagaa aaagataggg ttctaaaaac
    32881 tgacttctat tccttaaaaa cgaaccagct tgactgattc gtcttcttac gtttatctcc
    32941 tacttccgat acattttaaa ctgtaggaag aggtcgctat atttccctgt ccatttatgg
    33001 tcaaatttct cataaacttc taggtgtttc atggtttcaa catctggata gaaggcctta
    33061 tcttcctttg tttcctctgg gagcaattcc ttcgctggta ggtttggtgt tgaatagccg
    33121 acatactccg cattttggaa agcgttttca ggtttcaaca taaagttgat aaaggcatag
    33181 gctgagtctt ggtttttaac tgttttggga atgaccatat tgtcaaacca aagattgctg
    33241 gcctctgtcg gtaccacata acgtagattt tcattttttt ctaacatttg gctggcttca
    33301 ccagagaagg tcacgccgat tgcaacatta ttctgaatca tgtagccctt catctcgtcc
    33361 gcaacgatag ccttgatatt tggagtcagt ttgtagagct tatccactgt ctcttccaac
    33421 tgctgcggat ccttggagtt gaggctgtag ccgagggaat tgagtcctag tcccagcacc
    33481 tcacgcgccc catcaaaaag catgatagaa ttcttatact ccagcttcca aaggtcatcc
    33541 caatgctcag gcgcttcatc taccatggtt tcgttgtaga caattcctaa ggttccccag
    33601 aagtaaggga tggagaattt attacctggg tcaaaggact ggttgagaaa ctctggtccg
    33661 atattttcga ttccttcaat ttttgaataa tcaagcggaa ccaagaggtc ttcgtccttc
    33721 atcttgttaa tcatgtattc acttggaatg gcaatatcgt aggtcgttcc accctgcttt
    33781 atcttagtgt acatggcttc gttggagtca aaagtctcgt actgaacttg aattcctgtt
    33841 tcttctgtaa actgagtcaa gagttcagga tcgatatagt ctccccagtt atagataacc
    33901 aatttttgac tatctcgact attgatttta ctatctaaat gagtcgcaat tccccacaag
    33961 acaaggataa tcgctgcaat tcctgctaaa aatgaataga tttttttcat gcttgctcct
    34021 ccttctcacg agagataaag taataaccta caactaggat aatactaaag agaaagacta
    34081 gagcagacag ggcattgatt tctaaggaaa tccccttgcg agcacgagag taaatctcga
    34141 ctgatagggt tgaaaagcca tttcctgtta caaagaaggt cacggcaaag tcatctaacg
    34201 aataggtgaa ggccatgaaa taaccagtaa tgatagacgg agtcaggtaa ggaagcatga
    34261 tttccttgaa catctgaaat tgactagctc ccaagtcata ggccgcatga atcatgtcgc
    34321 cattcatttc cttgagtcga ggcaagacca tcaagaccac gataggaatg gagaaggcca
    34381 cgtgactaga tagaacggtc aaaaagccaa gtgaaaactt gagttgggta aagagaatca
    34441 agaagctagc accaatcata acgtcaggcg caaccatgag gatattattg agtgatagaa
    34501 aggcttcttg gtatttctta cgagactggt agatgtaaat ggcaccaaaa gtcccgataa
    34561 tggtcgctat caaggctgat aggaaggcca agaaaaatgt ctgagccaaa atcagcatga
    34621 gtctcccatc tccaaacatg gtttcaaagt gagtccagct aaaacctgta aagctattca
    34681 tatcatcacc agcattaaag gcatagccaa tcaagtaaaa gataggcagg tagaggacca
    34741 gaaagaccag tcccagataa aggttggcaa attttttcat cgttctctcc tttccttagt
    34801 cacccacatg gtgatgaaca tggtcaggat gagaatcaca ccgatggttg aacccatacc
    34861 atagttgtca ttggttagaa aattctgctc aatagccgtc cccaaggtga taacgcggtt
    34921 cccaccaatc aaacgggtca gcatgaagag actcaaactt gggataaaga ccgactgaac
    34981 cccacttcgc acaccgttca tagatagagg gaagatgaca tgacggaagg tctcccactt
    35041 agtggcacca aggtcataac tagcattgat gagattatta tccatatcgt ctaagacatt
    35101 gaaaatcggc aaaatcataa aggggagctc gatgtagctt gcgacaaaga taaaggaaaa
    35161 atcggtaaaa agcaactgtt gtgaaccaat tccgataaat tccaagaatt ggttaataga
    35221 gccattttga ccaaaaatcc cgataaaagc ataggcttta aggagcaaat tgagccaggt
    35281 aggaaggata atcagcatga gccagagttg acggtgcttg agacgggtca aaaagagggc
    35341 tgttggatag ctgataagca aggtcacaaa ggtcacaatc cctgcataaa gcactgagtt
    35401 gaaactcatt ttgaggtagg tcaagttttg tgacgcaaag taagatttat aattttctaa
    35461 actaaactgg ccttcaatgt tgaaaaagga ttgtccgaaa atcaagacca agggtgccaa
    35521 tacaaagagg gcaatccaaa gcatgtaggg cactacaaag agtttagagc ttgttttctt
    35581 catctctttc ctcctcgatc gcattgatca gacctgcttc ttgctcttcg atttccacgt
    35641 attcttcgat acgagcatcg aactcttctt cggtttcatt gagacgcatg atgtggatgt
    35701 cttctgattc aaagtccaga ccgatttcct cacccacgat ggccttacgg gttgagtgga
    35761 tcatccattc atttccaagt tcgtcatagg cgataatttc ataatgaact ccacggaaga
    35821 gctgggtgtc gaccttaact tggagtttgc cttcttcagg aagggtaatg cgcaagtcct
    35881 ctggacgaat aacgacctca acaggttcat ttggcttcat cccaccatca accgcttcaa
    35941 agcgtttgcc gttaaattcg accaagtagt cctcaatcat ggtacctggc aagatgtttg
    36001 actccccgat aaaggtggca acaaagtggt tgattggctc atcgtagatg tccacagggg
    36061 ttccagactg gacaatctcg ccatcattca taacgaaaat ccagtcactc atggcaagag
    36121 cttcttcctg atcgtgagtg acaaagacaa aggtaatgcc caatcgttgt tgtaattcac
    36181 gcaattcgta ctgcatgtct gttctcaatt tcaagtccag cgctgataaa ggctcgtcca
    36241 acaagaccac acggggttgg ttgatgatag cacgggcgat ggccacacgc tgacgttgtc
    36301 ctccagaaag tttgcggatg gaacgttttt cataaccttc caactgaacc atcttgagaa
    36361 cttccgctac acgctgctcg atttctttct tatcaatttt acgcaagcga agtggaaagg
    36421 caacattttc aaacacattc atatgtggga acaaggcata ggattggaag acggtatgta
    36481 cgtcgcgctt gttggttgga atatcattga tacgaacacc gtctagcatg atatctcctg
    36541 tcgtcgcatc cagtaaacct gcaataatgt ttaggatagt tgatttcccc gaaccagatg
    36601 cacctagaag ggtgtagaat ttcccttctt ccaactcaaa gttgatgtct ttgagaacct
    36661 tggtgttgct gtcttcaaaa actttagaga cgtttttgaa ttcgataatt ggttttttca
    36721 attggcataa attccttctt tttcatagat taaccgatcg gggctctgtc aggtccccac
    36781 tacctcttgc agggagtaaa accacctgca tacatcttcg ctaccgatag gctttcaccc
    36841 cctttccatg acatagcagc agcttttcaa atacagcttc ctacttgctt tcacccaaga
    36901 tccggacttc tctttcaagc gtaatacctg agtgttcctt gactttttcg ataaccgatt
    36961 ggatcaagtc ctcgtagtct ttggccgttc catctgcgac attgatcata aatcctgcat
    37021 gcttttctga cacttctacg ccaccgatac gatagccttt caagccagct tctgaaatta
    37081 actgacctgc aaaatgcccg actggacgct taaagaccga gccacaagat gggtattcca
    37141 aaggttgctt gagttcacgt aggtgcgtca agcggtccat ttcctgcttg ataacctgat
    37201 gggttcctgg ggctagggca aatttaactg acaagacaac tgcaccagac tcctgaatag
    37261 ctgaatggcg gtaaccaaaa gccaagtctt tagcagacag ggtttcgatt tctccatcct
    37321 tggtcaagac cttacaagac tgcaatatgt gagcaatctc gccaccatag gcacccgcat
    37381 tcataaagac agcaccgcca acgcttcctg gaataccaca agcaaactca aagccagtca
    37441 aactatgacg gagggcaatg cgagttgttt caatcaagtt agccccagct tctgcttcaa
    37501 tggtatagcc atcaacagaa acgttattga gcttgtcaca caagatgaca aatccacgaa
    37561 tcccaccatc acgaacgatg atattgcttg cattgccaag aaccatccaa gggatatttt
    37621 cttggttggc aaatttcaca acgcgagcca actcaaaacg atttcgtgga aagaccaaat
    37681 aatcagcctc tccacctact tttgtataac tatagctatg caagggttcc ttaaaacgga
    37741 tatcaattcc ttctaagatt tcaagcattt tttctcttac agacatgtca ctcttccttt
    37801 tacaaaattc attccattat accattttta gagacatttg acgaccataa aaataccttg
    37861 tttggatttt gcataagaaa aagaggttcc ccccttttta tgatttttta caaaagattt
    37921 ccttggttcc ataggcaacc agaacgagct ccagtgctag aatcacttca accaagactg
    37981 gatttgtcaa ccagcctact tggaaaagag atggtgccag atcaaagaag gcatgcaagc
    38041 cataggctgc taggagataa atccatttct tctggcgaac agcttggtaa acccaaactg
    38101 tcaaaagtaa ttggaaacca agcgccaaga ttcgctcaaa accaagcaaa taaatctgcc
    38161 agaccgaaag tgactgaatg gtttttaaca tattttcaga cagtaattgc ataacctgtg
    38221 gattctgagt ttgaactgcc gaaagaacga tgtaaagatt gagtaaacta gtaaggccta
    38281 gaaaaatcaa ctccaagcca ccatgcccta gaccataggc caaggcatct gccttttcca
    38341 aacttctctt tttctccaac catttgaaga aaacaagacg agccgtttcc tcaaaaaatg
    38401 ctgccatggc taggccatag ataatataga taagcggatg atcttgcaag agggcaatac
    38461 taccgtcttt ttgaggatgc aaaatcaaga tatgcaccag tttttccaaa atctgcgaag
    38521 agacaaagaa agcgactgca cccaagccca agacagctag attaatctgg tatttctttt
    38581 tggcaaacca aatgcttcct atcagaaaag ctagcaacag caacatggta ataatgatat
    38641 gaatggtcat tttcttctcc tattctgcct tttcaatatc ttttttcatc tcgtcaacat
    38701 tgaacttagc aaacaagtat tgacggtctt ggactgggaa acgttggtcc aactggtcaa
    38761 ctgctcccac ctcgataatg ccttccttga tgacaaaatc catgacatgt ccaccgaagg
    38821 tcaaatcatc tgatatgaag tgcagatggt agcctgccac actgacccca tggaaaatct
    38881 caggcgtcca gaaaccaaca atagtccccg caacattgtc acgactatat tccggttgat
    38941 gggttgcgat atcagcaaac ttggtatcgg gtgttgactt aggaatcata cgcacatgca
    39001 tatgtgaaaa ttccccccga atcttgatag agcggaaaag attttcccca tcataataag
    39061 actcaattcg ttctttcaat tccttgtctg tcatctcaaa gcgctggcgg aaaatgacct
    39121 ctgcctgatg cggtaccact gcagcgtaag gaataagggc atctggtgac acttccacaa
    39181 tttctggctg gtctcctgac tctttggcct gataagcctt gccatccaag acaatcaatt
    39241 ccccatcaat ggaatccaag gttcccaaac caaggtcacc atgttctagc aattctccta
    39301 ctgtcatagt accaccataa aggccagcca tcaaggctcc aagagtattg tattgaaata
    39361 atttcactgg ttcctgcacg ttcttatcca ttcactttct tgtctgttat tctataaatc
    39421 ttactcctaa gtataccaca tttgccccta gatgtgaacg agagaaacgc tctagacatt
    39481 gccaagaagg aaaaaaaagg gtacaatgta acaaaatcaa gggaggtctg gaatgaagaa
    39541 acaaagcaag tacaaagagg tcgtttccta tctgaaaaat ggtatcgagt ctggacgatt
    39601 tccgacgggt agtcgcctgc cttctatccg tcaactgagc cttgactttc actgcagcaa
    39661 ggacaccatt caacgagccc tgctggaatt acggcacgaa caatacctct atgccaagcc
    39721 tcagagtggc tactatgtat tagaacaagg gcaacatcaa gacctagaaa tcgaggttac
    39781 cgacgaacat gccagtgcct atgacgattt ccgactctgt gtcaatgaaa ccttgattgg
    39841 ccgagaaaac tacctcttca actactatga caatcaagaa ggattagaag acctaagaca
    39901 atccattcac aaactcctct ttgaccaagc tctctactgc aaggctaacc aactagtact
    39961 gacttctgga acccaacaag ccttgtttat cctctctcaa atatcctttc ctagccaagc
    40021 caaggaaatc ttggtggaac agccaaccta ccatcggatg aatcgcctct tgattgcaca
    40081 ggggctggac tatcaaacga ttgaacgagg cattgatggg attgacttgg aggagctgga
    40141 aggccacttc aaaacaggaa aaattaagtt tttctacacc attcctcgat ttcactatcc
    40201 cctaggccat tcctattctg agcaggacaa acgagctatt cttgacttag cagccaaata
    40261 tagtgtttat atcgtcgaag acgactatct gggggatttg gactctaaaa agggccagac
    40321 cttccactat ctagatacag aggaacgcgt catttatatc aaatccttct caaccagcct
    40381 ctttccagcc ttgcggataa cagcactcat tcttccaaat actatcaaag aagccttcgt
    40441 ggcctacaaa aatatcctag actacgacag caacctcatc atgcaaaagg ccctgtcact
    40501 ctatattgac agtcaattgt ttgaaaaaaa tcgtttggct cgcttgacca atcatgaatc
    40561 ttaccaaaaa caaatcgagg aaaggataac taaaacacct tgtccccttc ctcattatcc
    40621 cctacacgat ggtttattgc tagacctgag acagtatcct aaaatcgcca gtctcaaaca
    40681 cagtcaactg ggcttggact tctttgaaga ggcctattta agcacctgtc cttatcaatt
    40741 tgccaaggtg tccctagaca atctggaaaa tgttttaaac tatttaaaag cagaattgga
    40801 atgacatcca actctgcttt ttcttattct tcaacttcag ttaaacttgc tgctttttca
    40861 agatagcttt ggtaagttcc ttcatcctta agtttttgga tgaccttgtc taccacttct
    40921 ttcaaatcat cactattttt tctaagagca acggcattgg cgtcgccgtc cttcatcttc
    40981 aagctgacag ttgcgacagc taagccagcg tttttagcag cataactaag tgcaacaggc
    41041 tcatccatat gaacagcatc tatttttcca gcctgcaatt cattgactgc ttcacccata
    41101 ttagttaggg aagttaattg agcttttggc aattgttcct tgaccattga ttctggaaca
    41161 gtcccttttt gggctgcaat attagcactt tctaggctag ttaaatcctt gtatttttcc
    41221 acatcagcct tacgaaccaa gaaactaatc ttgttttcat agtatgggat tgaaaaatca
    41281 aagacttctt ttctctcgtc agtagcacta attcctgcaa ctgctaggtc agccttacca
    41341 gtttgaagac tggtcaaaac attgtcaaaa ctcatgctta agatttccaa cttaacccca
    41401 agttcatcag cgatagcctg agccatgtcg atgtctgcac cgactacctg gttctttcca
    41461 tcaaccaatg attgaaattc aaagggtgca tagtcaggac tggttgccac aactaatttc
    41521 cctttttgtt tgatagcatc cacagcagac tgagaaccat tagaacctga ctggcaagct
    41581 actaagaaga aacttgcaag aaaattacat aaaacaaata tccatttttt tgatttcata
    41641 aataaacaac ctctctgtta attttgtata attataacga tatccaagtt acttgtcaag
    41701 tgttttttaa atttttatct caaaaatatt ttttcgttca aaaaaaggag ccatcagttg
    41761 atttcaagct cctttttata cagaattaaa ctattttata gttcgacaat cttacctgtt
    41821 tcaaagtaga caacccattc acagatattt ttagcatagt caccgatacg ctccaagtag
    41881 gaaataactt ggaaataatc acgacccgta acaatggctt ctggattttt cttaatctct
    41941 tcagtcgcaa ggtcacggat agtttcaaaa tagtggttaa tttgctcatc catggaggcc
    42001 acccggtatg cgtcgtcaac agaaccatta agataaagat caagtgctgc ttcaacaacg
    42061 cttttaactt cacgtcccat ttttttaatt tcttcctcta cagctggaat gcgctcttcc
    42121 cccttcatac ggatggttgc ctgggcaatg gctacagcgt gatcccccat acgctccaca
    42181 tctgatacag ccttaaggac agtcaagact gtacgcaaat cttgagagac tggttgttgg
    42241 agtgcgatca tttcaaatga tttcttttcc agtttcactt cgtattcatt tacttctgca
    42301 tcatcttcga tgacctcttt tgccaggtca cggtcatgcg tgacaaaagc acgtaccgta
    42361 cgattgattt gtgagagcac ttcttgtccc atagcgtaga actggttatg taatttctct
    42421 aaatcttctt caaattgaga tcgtaacatc tttcatctcc ttatccaaat tttcctgtaa
    42481 tatagtcttc cgtttccttg tgttggggat caaggaacat ctgcttggta tcattaaatt
    42541 caatcaaatc tccatctagg aaaaatcctg tcttatcaga gatacgtgaa gcttgctgca
    42601 tggaacgggt taccagaagc atggtgtact tgtcttttag accatacaag gtttcctcaa
    42661 ttttaccagc tgaaatcgga tccaaagccg aagttggctc atccaagagg atgattttag
    42721 gactagttgc caagacacgg gccacgcaga cacgctgctg ttgaccacct gacaatccaa
    42781 tagctgaatc atatagacga tccttgacct catcccagat agaggcacct tgcaaggctt
    42841 tttctacggc ttcatccaga acctgcttat ccttaattcc attgatacga agcccgtaga
    42901 caacattctc atagatagtc atagggaaag gattaggttg ttggaaaacc attccgattt
    42961 ccttacgtaa ttcaaccgta tctgtacgcg gactgtagat gttgtggcca ttgtacacca
    43021 cggatccagt tgtggtcacc tctggattga gatctcccat gcggttgaga gacttgagga
    43081 gggttgactt ccctgatcca gatggaccaa tcaaggctgt aatttcctta ggttggaaag
    43141 atagggaaac actattcaaa gccttctttt tattataata aacggacagg tctgatacct
    43201 gtaaaatcgc atctgtcata cggtttcctt tctaaccaaa gtgaccagat acatagtcat
    43261 tggtggactg tagcttggca ttttggaaaa tagttgcagt cttgtcatac tcaatcaaat
    43321 cacccaagta aaagaagcct gtatagtcac ttgcacgagc agcctgctgc atattatgcg
    43381 ttacaatgat gatggtaaag tttttcttga gctcaaacat ggtctcttct agttgcatgg
    43441 tcgcaatcgg atccaaggct gaggctggct catccattaa gaggatatct ggcttaacag
    43501 agatggcacg agcgatacag agacgttgtt gctgaccacc tgataaggtc aaggctgact
    43561 tgtggagatc gtctttaacc tgatcccaga gggcagcctg acgaagggag gtttctacga
    43621 tttcatctag gacttgctta tccttaactc cagcacgttc atgcgcaaag gtaatattac
    43681 ggtaaattga cttagcaaat ggattggggc gttgaaaaac cattccaatg tgtttacgca
    43741 tttcataaac gttgatttct ggacggttga catcaattcc acgatagaga atctgcccag
    43801 ttactttagc aatatcaata gtatcattca tgcgattgag actgcgtaag taggtagatt
    43861 tccccgatcc cgacgggcca atcaaagctg taattttatt tctttcaaat tgcatatcaa
    43921 tccccttaat ggattcattt ttaccatagt aaacatggac atccttagta gaaagggcta
    43981 ctttttcttc aggaaaggta aggatatgct tctcatccca gttatatgtt gacatggctt
    44041 ctcctttagg cagcggttaa tttcttgtgt agatagcttc cgaacttacg agctccaaag
    44101 ttaaaaatca ggataaagat caggagcaca gcggcagaac ctgctgatac aattgttcca
    44161 tctggaatag tgccttcact attgactttc cagatatgga cagccaaggt ttctgcttga
    44221 cggaagatag agatggggct agtcacactg aggatattcc agttagacca gtcaagagct
    44281 ggcgccgatt gccctgctgt atagatcaga gctgcagctt cgccaaagat acgaccagat
    44341 gccaagacga cacccgttac aatacctgga agcgcttctg gaataacaac atgaaccact
    44401 gtctcccagc gagaaatccc aagagccaga ccagcctcac gttgggtatg gtgaacgtgt
    44461 ttcaaactat cttctacatt acgcgtcatc tgaggcaagt taaagactgt caaggccaag
    44521 gcacctgaaa tgattgaaaa tccatactca aactggacta caaagatcaa gtaaccaaag
    44581 agacccacca ccactgatgg taaagaggac aagatttcaa tacaagtccg cacaaagttg
    44641 gtaacaggac cttttttagc atattcagcc aagtaaatcc cagctcccat agaaagaggt
    44701 acagaaataa tcaaggtaat gaccaatagg aaaaaggaat tgtaaagctg aatgccaatc
    44761 ccaccacctg cttgaaaagc agaagacctt ccagtcaaga aagaccaaga gatatggggc
    44821 aagccccgaa ccaagatata gagaatcaag gaagccaaga ttgtcacaat gatgctagca
    44881 atcgtataga ggacagctgt tgcaagttta tctaattttt tagcgcgcat aatttttctt
    44941 ccctctttct ttcgtaatca atttaatcac actgttaaaa actaaactca tcaagagcag
    45001 taccaaggcc agtgaccaga gaacattatt atttacagtt cccatgacag tgttcccaat
    45061 tcccatagtt aatatagaag ttaaagttgc agctggtgtg gtcaaggaag ttgggataac
    45121 agctgagttt ccgacaacca tctggatagc taaagcctca ccaaaggcac gcgccatccc
    45181 aaagaccact gcagtgaaaa taccagaacg ggccgccttc aagattacac gccagatagt
    45241 ctgccagcga gtggctccca tagcgaaact ggcctcacga taataacgag gaaccgcacg
    45301 caagctatcc gttgtcataa aggttacggt cggcaaaatc atgacaaaga ggacggaaat
    45361 ccctgacaaa atcccaaaac cagtcccacc aaagacactg cgaacaaagg gaacgacgac
    45421 ttgcaagcca ataaatccgt acactactga aggaatccca accaggagtt caatagctgg
    45481 ttgtaaaatc ttcgcccctt ttggtgatac ttcggtcata aaaactgctg caccaatagc
    45541 aaagggtgtt gcgataaggg ctgagagaat ggtaacgata aaggaaccca aaatcatagg
    45601 aagggcacca aattctttac tagaaggatt ccaagttcct cccaaaagaa agtcaaagat
    45661 attcacacca ttgacaaaga aggtcgacaa gcctttttgc gctacgaaaa ccaaaatcat
    45721 ggccacaagg atgactatca aagaaagaca ggcaaaggtc aaaccttttc ctaatttctc
    45781 cagacgagaa ttctttgatg gaagcaacat tttcttagct aattcttctt gattcattat
    45841 tgtctccctt ccaacactgt cacagttccg gcagcatctt tttcaacctt catttcctta
    45901 atcggaatat acttcaatcc tttgacaatc ccttcttggg tctcatccga gagaacaaaa
    45961 ttgagaaatt ctgcagctaa ctcattgggc tgccccaatg tatacatatg ctcataagac
    46021 cacaagggcc aattattgct acttatattt tctggactta agtcatagcc attcaacttc
    46081 atgcttttga ccgaatcatc tatataggta agagataaat aagagatagc tcctggactt
    46141 tttgatacga ttgattttac cgctccattt gaatcctgct cctgactttg catggcagac
    46201 tgaccttcca taatgacagt atcaaaggta gcacgagagc cagagccggc tgcccgattg
    46261 ataacagaga tgggtaagtc cttaccacca acctctttcc aattggttac ctcacctatg
    46321 aagatttgac gaagttgctc tgtcgttagg ttatcaacat caacctcctt attgacaatc
    46381 agagccaagc cagctaccgc gaccttgtgg tcaacaagag cagaagcatc aattccgtct
    46441 ttttcctcag caaatacatc tgagtttcct atatcaactg ccccagactg aacctgggac
    46501 aagcctgtac cagaacctcc cccttggaca ttgaccgttt ttccaacatg gatcgtgcca
    46561 aattcatctg ccgctacttc aaccaagggt tgcaaggcag ttgagccaac agccgttatg
    46621 gattctccac gatcaatcca gctagcacag cctactaaac aagccgtcag ccaaaaagcg
    46681 ataagagaca gagcaagctt ttttcttttt ttcactgttt ttctcctcga aaataattat
    46741 gaatactgtg aattttttaa gtagttcttt atgagttgac gcatgaattc ttaccaaatt
    46801 tctgcgcaat tgattattta tataatatag gctatattac tctttcctaa cctccttttt
    46861 tcatatgtgg ataaaatctc ttgtctatcc cttcccccat tgtcacccat tatagtcatt
    46921 tcgtgtctct ttttcccctt tttaatgcaa gggaaattac tctccttaga tgataatcta
    46981 aaagctagaa aggtatctca aatctctcta ctctcccaga ctagtttaca actaaaagga
    47041 aaagattcta ttttatgaga aatctagttt acaagcggta agaacgctaa taactaaact
    47101 tcttgtactc tttgaaaatc tcttcaaagc agtgttttga gctatctatg gctagcttcc
    47161 tagtttgctc tttgattttc atcgagtagt aaaactacat gtgatggcaa tcaagatatc
    47221 aagaatcatc ctactaaaaa aatccatact ttcactataa catagaataa gatatttgac
    47281 tagcattttc atttgaatct gaggcctttt ggaaaataat ttttcaaaac atttccagta
    47341 acctttgcaa agcccaagcc attgccttta accaaaactt ggtaccaacc atttggcaga
    47401 ctttctgcca gctgaacggt ttctccagcc gcatacttga caaactcttc ttggccaatt
    47461 tcaaccgact gttcgacctg actcggtttc aaggctaaac caagagcgaa actgggctca
    47521 aagcgtttct tcttaaaagt acccagatgc agtccattgc gagcaatctt gagcttccct
    47581 aaatctggca aaagttctgg caagagataa agctggtctc caaaaatctg caagataccc
    47641 ggtagattga ccttcaaatg gttttgggca aattcctgcc acaaggcaac ttgttcacgg
    47701 ctgaggttac tcttacttgc cttaaattta ggagctggat tgttaccctt aaactgtaga
    47761 tgggcaacaa actgaccctc tcccttaaac tgatgagggt acatccgagc cgtttctggc
    47821 aggtcaatac cagctaccat tccattgata tgctctactg gcaacaagtc aaaatcatac
    47881 tcttccagca accaattgac aatctcttcg ttttcctcgg gtgcccaggt acaggtcgaa
    47941 taaaccagac gaccaccttc agctaacatg gtcactgcat cctccagaat ttctctttgc
    48001 aagctagcac attgactcgg ataatctaag ctccaatagt ccatagcatc aggttgctta
    48061 cgaaacattc cttcaccaga gcaaggggca tcaagaacga ttaagtcaaa atagccttta
    48121 aagaccttga ccaagcggtc ggcagattca ttggtcacca cgacatttgt cgctccaaaa
    48181 cgctccatgt tttcaaccaa aatcttagcc cgtttgcttg aaatttcatt ggaaacaagt
    48241 agcccctccc ctgctagata ggctgccagt tgagttgatt tgccccccgg tgcagcagcc
    48301 aagtccaaga ccttcatacc aggactgggt tgggctactt gagccaccat ttgagcagca
    48361 ggttcttgcg aataaactaa acctgtagca tgctcaggcg atttccctga aaccttccca
    48421 tagtggcccc aaggggtttg agtaatggca tcagaaaagg aaagttgctc ttcttttaag
    48481 ggattgaccc gaaaggccga aaccgcttcc tcctcaaaag aggcaagaaa atctcttgcc
    48541 tcatctccta gtatttcttt atatttttca acaaatcctt ctggaaattt catttaagtt
    48601 cttttccttt cgtaaatata ggactgaatt tcctcctgca tctcaagagg caccatcatg
    48661 accggctgtc tggtttgaaa atcaggagct tcaccaaaaa gggtcacaac ccgatagccc
    48721 agactttccc ctaaaatact agctgcggca taatcccatg gttgcagata ggtgagatag
    48781 gtcaacaaac gccctgacaa aatcttggca aaactaatgg ccgcacttcc atagacacga
    48841 acaccaagaa ccgctcggct caaatcagcc agcccccatt cattggtttc cagcatacca
    48901 ctattccctg caatgagaaa atctccaagt ggtttagttt taaaagaagc taggggccta
    48961 tcatttagac aaactggaaa ttccccacca ccgtggtaac aatccccttt gaccacatca
    49021 taaatcagac caaactgtcc ctgaccattt tcaaaataag ccatcataac agcaaaatct
    49081 tcctgctggg ctacaaaatt attggtacca tcaatgggat caatgaccca aaccttgccc
    49141 tcttgaaccg aggctcgcag acaaccttct tcagcacaaa tcttatcctc aggataacgg
    49201 gacaaaatct caccaaccaa gagttcctga acttctttgt ccagtctggt caccaaatct
    49261 gttggagagg acttggtttc aacacgcaag tcttcctgca tatggtcaag aatgtactga
    49321 cctgctttct taacaagctc tttagcaaat tcaaatttac tttccaagag aaatctttcc
    49381 ttcccctttt tctttggcag cctgaactgc tcggtaaagt gaatagccac taaccgtttc
    49441 aaattctcgt cccaaacgtt tctcttcgct cttgcttggc acgaccgctt tgaatccctt
    49501 ataggagtcc agtaactttt tagcctctac tttgccttca taggcagctt caacatcatt
    49561 aaaaaaagaa agcactgaag caagttcttc agtgctccac gacaaatcta gtgggtaact
    49621 atactgtttg ttcattaact aataccagct ctcattcttg cttcttttag ttcttgctta
    49681 cgataactac gagggagaaa agcacgaatc tcatcttcat taaaaccgat ttgcatacgc
    49741 ttggcatcaa taataattgg acgacgcaaa agactaggat actgctcaat caaatgaagc
    49801 aattccgata ccgaaatact ctctacatca atattcaatt tttgaaaaat ttttgaacga
    49861 gttgaaatga tgtcatcagt accattttcg gtcaaggaaa ggatgtgttg caattctttt
    49921 cttgttaaag gactggtcat aatattgtgt tccacaaagg gaaccttatg tttttctaac
    49981 caggccttag ccttacgaca tgatgtacag ctcggtgata gaaatagtgt aatcatgctt
    50041 ttctcttctt atctatactt tgctacttct attatacaaa aaaataaagc gcttgactag
    50101 ggatttttag aaaaaaaagc ctatttttca agaaaaatag gctttttgcg aacgattgac
    50161 acaattggat ttggttaatt cactcttaac gatggtttta aacgatatat atttttatat
    50221 atgcaaatta aaaacatctt tcatttccta cgacttttca gacacagata gccaaagaag
    50281 ctttcataga gggcaaaaaa gaggaggaag gcatgaagaa agaaggtctc tggcaaaatc
    50341 ataataacag gatccttggc tggatcaaaa agccaggtat catctcccac aaagagaatt
    50401 tgatggaaaa gagtaaagaa ttggtcaaaa ccaatcaaaa ctcccccaag tccaatcatc
    50461 acaggtaaga ctactagagt caggagactt tttcgataaa gagacaaaaa gtcctttttc
    50521 acaattctat tgacaaagac atagaaactt ggcagtgtca ctagagctac tagctgaacc
    50581 aaatgaaaga gattcttgac cactgcgaaa tggtgcagac cagctgctga cgaacgaaaa
    50641 tcaggcatct gtaagacctg actaaaagga ttggtcagat aattcatcaa gatatgaaaa
    50701 ttgtattgaa tggtttctgg ttttagatag actcgattcg ttaagtttag ccactgaatc
    50761 tccataggat agaaaatcca agccagataa atggtcagaa ggattgagag ggagaggaga
    50821 aagagcatag agccccaaaa gatcaattta gttttcatca aaatcccact ccgcaaggct
    50881 agaaaccaca tgtgtcggtg cgattggcag gccagctact tcttctgcct tagtaaaacc
    50941 tgtcgtcacc aagagcgttg gaatgccatt gtcaatccca gcccggatat cagtcaaata
    51001 attgtcccca accataatta actcttcacg ttccaaacct aagtgctcaa ccgccttgtc
    51061 cataatgatg gcattgggtt ttccgatata aaccggcttc actcgtgtcg ctacttcaag
    51121 cagcgtaatc agggagccag cacctggcaa aagaccacgt tccgtcggga tgttgaggtc
    51181 aggattggtt ccgataaaat gggcaccctt ttgaatagca agagttgctg tggcaaattt
    51241 ttcatagtcg acttgccaat ccagaccaac taccacgtag gcagggtttt ccttgtcttc
    51301 cacataacca gccgccttga tggcttcctt gagtcctgct tctccgacga catagacggt
    51361 cttttcaagc cccaaatcat tcatatagtc gatggttgcc aaagtcgctg tgtagacagt
    51421 cgataggggc gtatcgatat taaaattctg agccaacatc tccttaacac tctctggagt
    51481 gcgagttgta ttgttggtta caaagagata gggaatgtcc cgcttttgca attcatgaac
    51541 aaaagtctct ccagcaggga ttcggtcttt ccccttataa atggttccgt ctaaatcaat
    51601 taaatagcct ttatatttca tctatttctc cctaagcctt ttttatttct ttccaagtaa
    51661 tgattgcttg ggcattgata accccatcac ttgtaatttc atgcttgctt tccagtccag
    51721 tccgttcaac agccgatgta atcaccccac ctggtcgaac ttccttgaca tacttgaggt
    51781 tgattttctt gggaatatag tgggtcaaaa aatccgctcc catgacctca aaaatccagt
    51841 ccaagtattt actgttattg acatgaccat tcatatccaa gtcgtaaaaa cgaacatggt
    51901 aatccttgct gatcggctct tccaaggact catacttcgg tccacggata agttttttat
    51961 caaaatcaga ctggtaagga gccacaatct caggttcaac agcatggact tttcgactgt
    52021 cgcggtccat gagaacaaag gtcgccatca tatggatgag ctcctgcccc gcttcattat
    52081 aaatagtaaa gcgacggtag caaaaaagtc gattgtagct caaggcttcc gtttcgatgg
    52141 taatttcttc cgcaaaacga ggcaaacgaa ccacctcaat atcatattct gcgataatcc
    52201 agaccagatt atagtcttcc aaaatggcct tatcactaac tcccagttca atcgactgca
    52261 tccctgaaac ttgcagtgac agcaaaatca catctggaag tttgatatga ccgttcatat
    52321 cagccatatc aaaaggaatt ttcattttca tttgataagt taagcccatg atcctactcc
    52381 aaaataaatc gttctgctac agtatctccc aaaaagagac ctctctttgt catgcgaacg
    52441 tggtcaccct caatctgcat gaggccttgt tgaaccaaat ctctgacaat ttctccataa
    52501 agtccagcaa aagactgtcc aaatttttcc tcaaatcgcg ccatggaaac cccggatttc
    52561 ttgcggagtc ccaagaacat ttcttcttcc atttgctcct tttgactcag gtgatcttct
    52621 gtaatacaag cattgccttc ctcaaccgca ctgagataat gacgaatggg accatgattt
    52681 ttataacgta ctccattgac ataaccagat gcccctgcac caataccata gtattcagca
    52741 ttgtcccagt acatgagatt atgacgactt tcaaagccgg gtttggagaa attagaaatc
    52801 tcataatgct caaaacccgc tcgctccagc tctgcaatga tgtactcaaa catctccgct
    52861 tctagttcct ccttaggcag aggcaatttc ccacgtcgca tccggttcat aaagaccgta
    52921 tggttttcta aaatcaaact atacaaactc atgtggggaa tatccagtcc aatggcttta
    52981 gccacatttt cctttacttg ctccatggtc tgaccaggca gagcataaat caaatcaatg
    53041 gagatgttgt caaaaccagc cagtttcagg cgatcgatat tttcataaat atccttctcc
    53101 aaatgactgc gcccaatctt tttcaacatc ttatcatcaa aggtctggac acctagcgaa
    53161 acacgattga cagccgaatt tttcaaaaca gctatcttat ccgcatccaa atcgcctgga
    53221 ttggcttcaa tggtcaactc ttccaagaca gacaagtcca agtttttagt caagccattc
    53281 agtaaaacct ccagttgcgg agccgacagg gctgtcggtg ttccaccacc gatataaagg
    53341 gttgacaact tttcaatatc ataagaacga aactcttcca gcagatgctc taaatagctg
    53401 tcgactggct gatttttgat gaagaccttt gaaaaatcac aataataaca aatctgggta
    53461 caaaatggga tgtgcacata ggctgacgtt ggttttttct gcatagtaat tattatacca
    53521 caaagactag attccagata aaaatcacca tccccagata catagtccgt ccggagatgg
    53581 tgatggttta ttcttctgtt atatcaatca caatctcttc tgagtcatca agagcttcgg
    53641 ctttttcttg ccattgctcc ttgagattat ttaattgatt ttttgatgct tctgtcgctt
    53701 gaagagcata ggatttagct tgagcaagta tactgtccac agtgatttca cctgactcaa
    53761 cctgttcttt tgttttcaga acaaaatctg tagcctgctc cttaacttct gtcagttttt
    53821 cacagacttg ctccttggca tactccggat cttctctcaa atcatctaga aaatcttgag
    53881 cctgactgca aacttgtttg cccttatcac ttgttaaaaa caaggcaaga gctgcacctg
    53941 aaacggttcc taaaaggatt gaggataatt tacccataag gattctcctt ttttattttt
    54001 tgaaaaattt acttgcaaga cgaagagctg acagacttgc accagtcttg agtgtttttg
    54061 aaccagctga tgaagctttc ttgctcaaga cacgcgcatg gtcattgagg tctgaaacag
    54121 atagagataa atctgcaaca gcactgaaga gtggatcaat cgtagccacc ttgacattga
    54181 tatcatctgc caagacattg accttagcca acaactcatt ggtgtgatgc aaggtcacat
    54241 ccacatctga agtcaaggtt ttaatcgtct tttctgtttc atcgatgaca cgaccaagct
    54301 tttgtacagt aatgatcaga tagaccaaaa agacaatcaa agctagggca acaagaatat
    54361 atgcaacttc taacatttag ttttcctcct ctgtaatata gtaaggggcc ttctttcgat
    54421 tttgataaat aacgatcatt ataccgagac cgataaggac aactgacagc cattgggaca
    54481 ctcgaaggcc gaagaacatg agactatctg ttcgcatacc ttcgatgacc atacgaccga
    54541 aaccatacca aatcaagtaa aaggccgtga tatgacctcg tctgagactc ttccatttcc
    54601 gtctaaaaat cagaatcaag gcaaagccaa gcagattcca tagagactca taaaggaaag
    54661 tcggttgacg gtagctcccc tcaatataca tctggtcacg gataaagcca ggtagataat
    54721 ccagattatc cactgttgca ccataagctt cttggttaaa gaaattaccc caacgcccca
    54781 aactttgagc aatcataacg ctaggcgccg caatatctag aaaatcccaa gtattgatga
    54841 gtttacggtc agcaaagata tagagcacaa gagccccagt tatcaaacca ccgtaaatgg
    54901 ccaaaccacc attccaaatg gcaaaaatct ctcctaaatt ctgactatag taatcaaatc
    54961 ggaaaataac atagtagaga cgagctccta aaatagccaa gggaaaagct actaagataa
    55021 aatctaaaat atcgtctggt atgatcttct ttctaggtgc ttctttcatg gtcaaataaa
    55081 ccgcaagaat caagcctgtc acaatacata aggcatacca acgaatggct aggggtccta
    55141 gttgaatagc aattggatca agcattttgc acctcatttc gagcgatgag acttgtcagt
    55201 cgttcgtcga acaaacgggt cgcatcaaag cccatttcct tggcacgata attcatggca
    55261 gctgcctcaa tcacaacaga gatattacga cctgttttaa ctggaatacg aatacgagga
    55321 atggctacgc cagaaacttc aagttcctct gcattgtttc caagacgatc aaaggtctta
    55381 tgcgtatcgt aattttccaa atagacagca agctgaacct gtgaagaatc cttgacagca
    55441 ctcgcaccgt agagactcat aacatcgata ataccaaccc cacgaatttc aatcaagtgt
    55501 ttcaaaattt cagctggttc accccagaga gtaatctcat ccttggcaaa gatatcgaca
    55561 cggtcatcgg ctaccaaacg gtgaccacgt ttgacaagct caagacctgt ctcgctctta
    55621 ccaattccac tatctccctg aatcaagacg cccatcccat aaatatccat caagacaccg
    55681 tgcacactgg tacgttctgc caaacgagaa tccagatagc tagataactc tccagataaa
    55741 cgactggtag ctgcacggct ggttaaaata gcaatcttac attctctagc agcctttaac
    55801 atctcctctg gaaccaccaa accacgggca acaatgactg ctggtgtctc aggtagaaac
    55861 atttttttca aaacttcata acggctgttg gaaggcatgc tgatcagata agaccactcc
    55921 ttcatcccca aaagttgaat ccgctctggt gtatagtagt caaaatagcc tgtcatttca
    55981 agaccaggtc gcgtaatatc cgctgtattg atttcctttt caagcaattt tggttcacca
    56041 tagacaatgt ctagtctaag cttttcaatc acttctttta ctaaaaccga catcatttcc
    56101 tccttcaaat gagttcttct ctctattata tcaaattgta ggaggaagtt tcagattttt
    56161 gcaggctttg gagtatttat ttaaaagaaa aaggactaga tttctctagc ctttcattcc
    56221 aattagaatt ttttacgttt acgagctact tctgatttac gtttacgttt tacagaaggt
    56281 ttttcataga attcacgttt gcgtgtttct tgaagagtac cagctttagt aaccgcacgt
    56341 ttgaaacggc gaagtgcgtc gtcaagagat tcattcttac gtactactgt tttagacatt
    56401 tttttcactc ccttcaagtt caatatctat ttcattctac acgtaaaagg aataattgtc
    56461 aagcaaaaat gcggtttaat tttgattttt tcttccattt atacaagagt tgaaagcgtt
    56521 caatagaaca ttgctttttt atttttcgag taagctaagc gcttcagcat ctgcgatgat
    56581 ggttacatca gggtgatttt ggaggctact tgcaggtagg ttctcagtca ctgggccaga
    56641 tactgttccg gcaatggctt ctgctttcga ctcaccgtaa gcaaaaagaa taatagactt
    56701 ggcatccaaa atgtttttaa tccccattga aatagcttgg gttgggacgt cttcaatctt
    56761 ggcaaagaag cgtgcattgg cttcgatagt agactggtca agttctacta gatgcgtttg
    56821 actgtcaaat ggagtaccag gctcattaaa gccgatatgc ccattgcgac cgattcccaa
    56881 gatttggagg tcaactggat ggtcagccaa aatttggttg tagcgttcaa cttcagcttc
    56941 agcattgtcc ttaacaccac gaggcaagaa actttcttta aatggttttt ggttgaacaa
    57001 gttttcttgc atgaagtaac gataagactg tggattgtcc ccatcaaggc ccacatactc
    57061 atcaaggttg acactggtta gatttgaaaa atcaaggtca ctctcaacaa tttccttgta
    57121 aaattcaagt gggctacttc ctgtcgcaag tcctagagtt tgagctccat tagccaattt
    57181 ttccttcaaa atctcaaaag caacttttcc accttgaact tggttttcaa ctttaataac
    57241 tttcatcttt tcatcctcca tttctgtcta tatttattat atggtataga ccaatttttg
    57301 tcaagtgaaa acgatttaat ttctaaaaaa agagcgtcca aacttgaaac gtgttataat
    57361 ggataggatt agaacttaga aagaatgaac agatatatga atacagctga ttttgatttc
    57421 cacttgccag aggaattgat tgcccaaacg ccccttgaaa aacgtgatgc ctccaaactc
    57481 ctcatcgtca accgtgagac aggagaaatg caagataaac acttccactc tattattaat
    57541 atgctggaac ctggtgatgc ccttgtcatg aacgacaccc gagttctccc tgcccgcctc
    57601 tatggtcaaa aagtggagac aggaggtcat gtggaacttc tcctccttaa gaacactagt
    57661 ggagacgagt gggaagttct ggctaaacct gccaaacgcc tcaaggtcgg tactcgtatc
    57721 agctttggtg atggccgcct cagcgctgtc gttacagaag aattgaccca cgggggacgc
    57781 attgtccgct ttgaatacca aggaattttc ctagaagtct tggaaagtct gggagaaatg
    57841 cctctgccac cttatatcca cgaaaaatta gatgaccgtg aacgttatca aaccgtctac
    57901 gccaaggaaa gcggctctgc tgcagcaccg actgctggtc ttcacttcac caaagaactg
    57961 ctggcagaaa tccaagctaa gggtgttcat ctagtctatc tgactctcca tgtcggactc
    58021 ggaaccttta gacctgtttc tgtggataat ctggacgaac acgaaatgca ctcagagttc
    58081 tatcaacttt ctgaggaagc tgctgccacc cttcgctctg tcaaaaaaaa tggtggtcgt
    58141 gtcatcgctg tcggaaccac ttctatccgc accttggaaa ctattggttc caagtttgat
    58201 gggcaaatcc aagcagattc tggttggacc aatatcttta tcaaacctgg gtatgagtgg
    58261 aaggtcgtgg atgccttctc aaccaacttc cacctgccaa aatcaactct ggtcatgttg
    58321 gtttctgcct ttgcaggccg tgaattagtc ttagatgcct accaccattc catccaagaa
    58381 cactaccgct tcttcagttt tggtgacgcc atgtttattt attgagaaag aatttctcta
    58441 aatcttctaa taccaataaa tcgctaagat attatttcaa agaacatcta caattgaaac
    58501 tctagctagc tgtagaagag gtctagtaca ttgaaattaa aatgcttccc cctagcttcg
    58561 aaaatattgc catagattgc gttgactctc caaattgatt catctatatt ttatttcagc
    58621 ttcctatact ttcttcgctg tttgtaaatc aaaatgcaag acacatgagt agcaccatat
    58681 ttgttactct tatctgtcct ctcaagagac tattatgagt tatttcagaa tcattcacta
    58741 ctttgaccct gactctcctt agtctcaaaa tcaaagactt atactcttca aaaatctctt
    58801 caaaccgcgt caacgtcacc ttggattata tatgtgactg actttgtcag ttctatctac
    58861 aacctcaaag cagtactttg agcaacctgc gactagtttt ctagtttgct ctttgatttt
    58921 cattgagtat taaacaaaaa gtgaacaaag ctgaattcta atgtacagaa gactaggctt
    58981 gttcactttt ttatagtcgc tataagatga ccttatctat agctttttat atataattat
    59041 atattcagac atactattat caattttgtc tcagggagga atctgttaac gcacccattc
    59101 accattatca ttgactctat agccatctat acttgtattg accgctaact cacccgatgc
    59161 atttacataa taccatttac caccaacttg gaaccattga ttaactttca tagaaccgtt
    59221 gctgttgagg tagtaccatg aaccattaac ttgtacccaa cctgttgcca tggaacaaga
    59281 acttcttcaa ccttgctttt agctggaact ttgataactg tatccgtggc ttcttttcta
    59341 tcaacagtaa cctgttcggt aacatgacca gtctctggat taacatcgta ggtccttgtc
    59401 gtagttacat agccatcctc tccatcaatt gtaacaggat tttcactacg gtcttttgtt
    59461 tcatcttttt cataacgaat tcgcgtactt gaaattttct tggttactac cttaggttta
    59521 gtcgctactt ttacaataat atccccattg tcagcgtcat catactctat tccctcttct
    59581 ttatctctag tatcatctct gacatattga atcccatcag cagcatgaac aaaacttgta
    59641 ttcagattcc tcctaaaaat aaagttagcc cgattaccgc agaaccaaaa atctttccga
    59701 gtttacgtaa tgcatagcgc ttattggtat tagattttgc cattacatcc tacttctaaa
    59761 agttactact tctagtatag catcttttct atcaaacgtt aaacagtata ctttatatat
    59821 caaatatact tagaatgata tattgattat tgaactaacg ctttaactat atcgtaatca
    59881 atctcatata taaaggattg cagacatctt atctaaatac atgctaatat atttagatac
    59941 aaacattcca acttgataac tttcactcat ctttcatcat tccttataca actatgcagt
    60001 ataaatagaa tagttttctc atcagaatga gactatttta atattagata ttttgataga
    60061 aaaaacatga ataaaattgg ttgaatttaa ttccctaact cgatagagga ttctatttta
    60121 aatttaacaa cagctaggat tacactataa aaagtacatt accacctgtt cggctggaga
    60181 atctagtcga ttagctccct cttagttaca agcttaaagc gattttttaa ctaatactaa
    60241 accagattaa agaaggaact agaacatctg tcttgtacta atcaatatgc tattttaaag
    60301 tttcaaataa acttggaatg ctaattatta tatttacaat aaatagttga cttcgataga
    60361 aacagaaaat agaattcaac attcttccct acttatacca taataaataa gatccgcaag
    60421 atagcctttt ctctctacac cattaacaat ggtttgtaga taggacattc cagccttttc
    60481 catgacacga cctgaagctg ggttgagact ggcataacgt gctctgacct tttgaaaacc
    60541 tgcttgagta aaacaaaagt ccaagatagc tttcaaagtc tctgtcatca taccatttcc
    60601 ccagtaagcc ttgcctaaca catagccaat ttcacagctt aaatcagcct cgtctatctt
    60661 aacaatgctg atatctccta tcacttgctc tgggttttct tttagacaaa tggcccattt
    60721 ataatagttg agattagtat aggaagcaac ccaattgcaa atcgagtttc gagtgatttc
    60781 gacatcagga tggggatccc aggtaacata ggtcagattc tcagcggatg aagcccaatt
    60841 ttgaaacatg gcttctgcat cactctccac aaatcttctt aaaatcaaac gttctgtctg
    60901 taatatttgc gtaccgatag atttcatgat gctacctcac ttccttattt ctatgctcgt
    60961 agtaaaaagg ctcaactcag taacagctag aaaacgagtt tgtcttctaa tttcttgacg
    61021 cagtcgctgc ctggtttgaa atgcgctcta gcaatctttt tcaaacctag tcatcgttgc
    61081 aggggtaaga cgatgaaatc gaactcttcg agttaccgaa tctgcctcat tttcttattt
    61141 caagatgaga ggctgaaaac ctccagtgga ggtttttctt gctttttaat ttcagggcaa
    61201 gaagctaaaa aggtcccccg gaccttcttc gctttctcat ttctaggctc agggtaaaaa
    61261 cctccaatgg aggtttttac tcccaaaagt catcaaatac ggtgatgggt aagtggcgtt
    61321 tgtgttggcc tttgtgccac cagttttcaa tggtcgcttg agcttctggg ctgattgttt
    61381 tgccttctag gtaatcgtca atctctgcat aggtgactcc aagtgcgact tcgtcagcta
    61441 ggcctggttt gtcttcttct aggtctgccg ttgggatttt ttcataaagg gctgggtctg
    61501 caccaagttc ctgtaagagt tgttttcctt gacgtttatt gaggcggtaa agagggagaa
    61561 tatccgcacc accgtcacca aacttggtaa aaaagcctgt gatattttcc gcggcgtggt
    61621 ctgttccaat gaccgctccg ctatgggaac cagcaagggc atactgagca atcatacggc
    61681 aacgtgcctt gatattcccc ttgttgaagt ctgaaacagg actacctgtc gcttcaactg
    61741 cagctgtcat ggtatcagct gattccttga tattcacaac caagctgaca tctggctgga
    61801 tgaaggctag ggctttttga gcatctgctt catcagcttg cactccgtat ggcaggcgga
    61861 cagcgataaa tttgtagctg tcgtctcccg tttcagctcg cagttcttcc atagctaatt
    61921 gcgccaaacg ccctgccaag gttgagtctt gtcccccaga aatccctagt acaaaggttt
    61981 ttaggaaggg atgttttttc agatatcttt ttaagaaatc aatagaacga cggatttctt
    62041 cctgggcatc aatcactggt ttgacaccca gctcttggat aatcgtttct tgcaaactca
    62101 ttcttcttct ccttcaccaa gggcttcctt gcgcatctta tcaatcaagt ccatcttatc
    62161 ttgccataca tcacgcgcca aatccactgg atagtgctgc ggattgagca cacgcttata
    62221 ctcatcccac aacttgtcaa attccttacg ggcataatcc tgaatgtcag tcaaactagg
    62281 caagttgtaa actaatattc cttctttgaa gatatccacc aagagaggaa cggcatcaaa
    62341 attacgaacc gtcttcttga tgtatgtata ggtcggatgg aacatcttga tttctgtcat
    62401 gtcgctaata tccacaccat cataagtgat gtagtcacct tctgacttgc ctttttcacg
    62461 actggtaatg cgccacacct gcttcttacc tggcgtcgac actttttccg cattattaga
    62521 cagcttaatc gtattgcgca tctgaccagt ttcatcttca attgcaacaa tcttgtaaac
    62581 cgccccaaga gccggctggt cataggctgt aatcagcttg gtacccacac cccagacatc
    62641 aatcttggcc ttttgcatct tgaggttaag gatggtattt tcatctagat cattagaagc
    62701 ataaatctta gcctctgtaa atccagcctc gtccagttgc tgacggactt tcttagaaat
    62761 gtaggcaata tccccagagt caatccgcac acccataaag ttaatctgat cacccagctc
    62821 acgcgccacc tgaatggcag ctggtacacc gatgcgaagg gtgtcatagg tatccacaag
    62881 aaagacacaa tttttgtggg tcgcagcgta agccttgaaa gcttcatagt cattgccata
    62941 aacctgtacc aaggcatggg catgggttcc caaaacagga atgtcaaaga gcttacccgc
    63001 acgcacgttg ctggttccat tggccccacc aatcaccgct gcgcgtgttc cccagatggc
    63061 cgcatccatt tcttgagccc gacgtgtccc aaactccatc aagggttcat cttcgataac
    63121 cgaacgaata cgagctgcct tcgtcgccac caaggtctgg tagttgacga tgttcaaaag
    63181 agccgtttcg accaactgac attgggctag aggtccttcc acctgcacaa tcggttcatt
    63241 agcaaaaacc aaatcccctt cttgggcaga acgaacggtc aactccaact tgaaattgcg
    63301 aaggtaatcc aagaacgccc catgataacc aagcgactcc aaataggcta tatcactatc
    63361 tgaaaaacgt aagtcttcaa gatagttcac aattctttcc aaacctgcaa aaaccgcata
    63421 gccgttctta aaaggctgtt ggcggaaata cacctcaaag accgccttct tattgtgaat
    63481 cccttggtca aagtaaacct gcatcatgtt gatctggtac aagtccgtgt gcaatgtcaa
    63541 actatcatct ggatacatac ttttcctact tccttagcta gaaacccatg aaaattttca
    63601 agaactttca tgtattccaa taaattagta ctattatatc acattttagc tggattgaga
    63661 aaagagtaac aagctattct ccactctcca attcatccat atcttgttca aattttttct
    63721 gagcccattc gccatagctc ttaagaccaa gattgccaat aaagacccac ggaaggtaaa
    63781 tgacatatgt aatgacccca gcagacaggt atttaaaatt caaaggattg tgctgataaa
    63841 tttctatgtt gaattgataa ttctgcaaca tcaaaagagc cgtaatagcc aaggttagga
    63901 aaaaacaacc caaaatcgta aaatgaaaac gactatagta ggtcactccc agataacggg
    63961 cgcgattgaa aaagtaaaat gtccctatga tgataacgat tagcagcata ttagaattaa
    64021 aaaggcttgg tgctaatact gaaatgatat aagataggag cgacaaagca atgcagatat
    64081 agaaactttc agagcccgct ttattgaaca gttgttcttc tctttcgtct agtaattgat
    64141 aataataaaa tctatttttc atcttcttcc tcccaaaata gttggtctag ggttttccct
    64201 aaacatctgc aaatagactg gcagagcgag agactgggat tgtattttcc cgcctctatc
    64261 aaaccaatag tctggcgtgt caccccgaca gcctctgcca gttgaccttg tgttaaatca
    64321 cgctctaccc gagctaattt taattttaaa tttttagcca ccttcgtcct ccttatagtt
    64381 ttaatactca tctactctta aaaaatccaa aaccaacaca agctatcagc tatttattat
    64441 aaccccatta atttgcactc cagtattatc ttcagccgaa aatcagtatt ttaggttgtt
    64501 tgaaataaac ttcctagttt actcttttat ttttatttag tattagcttt agtagaatct
    64561 tttaaacgag tttttattgc ttatatttct tgtttagttt agttggtttc atatcactat
    64621 tatataatgc ttttggaaat gagcctagta taagtcaaaa acgtgttgaa tagtgaaagc
    64681 aggagcatac caagatgact gattttttta ttgtatttta ggtatgcaaa ataatactaa
    64741 atgaaactaa aatgaatact tcttgctttt cttgagagtg aaaaagtaca ataaaatgat
    64801 tgtagtgatt accacaagat actgactaat agacatcgta tttgaagcca caaatacagg
    64861 taaagaataa aaaggaagaa gttcaattgc tttgataaac aaatcattac tagtattcat
    64921 catcatcgta tttaatatat tagggataaa gagtagtaaa gctactaaaa taccaaatcc
    64981 caagccactt ttcaatttgt ataaatagaa aatgtaggat aatagaaaat aaaacaggac
    65041 taacaaaatt gtattgacta caatagctac tataaaatct aatcctaaat cacctggaat
    65101 acccaattta cttacgatga ctagtaacac aatgccattc aaagcataaa taatggaaac
    65161 tgagatggca tatagaaaat tagacaagac gtaaatcatc cgattcttct gttgattata
    65221 aaacaaactt accgtattgt gggaaaaatc tctactaatg actcgattag catgtataac
    65281 agccattaac ataccgagca tagcataaaa gtttgaaata tgcttaatac caagcgatgt
    65341 cccttgagtc tttagaataa agaatgtaag caatatcggc ggtataaacg agataagcaa
    65401 actgagatat attacgcctg atgaatataa atttcttata ttttccttaa gaaaattcaa
    65461 tttatttaat ttcatgatta taaccttcct ttattttgaa cgatttaagt aaatatcttt
    65521 aagcgtctct tttttagttt caaaatcaac tactttaata gagttttcgt taaaaaattt
    65581 aaaaaactca ctactttgaa tattcccaga catagtaatt ctcagtccct cttcctgaac
    65641 aatatcccca aattcttgtt tggtaatgaa aatgtctcta tctgtagctg atgaaaaagc
    65701 tatctcaaac aagaaattat gactatcttt tcctactttt tgaaatgtca aaagcccgtt
    65761 ctccaagaaa agaactctct cacaaatttc ttcaatgtct tctaatttat gactcgatat
    65821 taaaattccc acattttcat gtaaagctaa attttttaga accgctaaaa ctatttgtga
    65881 tgattcaata tctaaaccat tagtcggttc atctaaaatc aatatatcag gttccgtaac
    65941 gagagttaga agcaaagcta atttttgttt tgtacccaaa gaataggtct ttactttttt
    66001 attaatagac tgagtcaaat ctaactcttg gatcaaactt ctaaatattt cttgattgta
    66061 gtcaacacca tataaatttg acaaatattt taaattctct aaacctgttt tagataaaaa
    66121 taattttggt tcttcgatta aatacccaac attatcactg cttataatat tacctgaagt
    66181 cggttgatta ttctgaacaa gaattttcat caacgtactc ttaccaactc catttctccc
    66241 tgctagacca acaatttcac ccttgttaag tgcaaaattt atatctttga gaatgattga
    66301 ataaccataa tgcttactta catttataac ttacattttt tattcctcca ttaatattca
    66361 tggtttgctc tttgattctt attgagttta aaaagttgca cctcttttta acaatattat
    66421 atcatatatc taacttaatg caatatataa atgtcatttt gtaaaatttt attaacaaaa
    66481 aactctctac aacaaaataa tagagagttt tctgcttatt aatttttttc aaaatatcta
    66541 agacatcgct tctttgttta atttgatagg ctttaatacc taagctccga ctttatcact
    66601 taaaaaataa aaaaggacag ctaatctctt gcgcatcaag ggatttcgcc attctttaat
    66661 ctcgtttaag tgttgtatat ggagctttgc ataatttttt aaaactaaac aactacatta
    66721 agcacgaact gtgacgctgg ttccatcttc cttataaaga ttgataagcc cctctttaag
    66781 agctcgaacc atgtctccag cttgaac
//
LOCUS       DAVLHC010000005        63905 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.005, whole genome shotgun sequence.
ACCESSION   DAVLHC010000005 DAVLHC010000000
VERSION     DAVLHC010000005.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 63905)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 63905)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..63905
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.005"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            266..922
                     /locus_tag="VXE25_000312"
     CDS             266..922
                     /locus_tag="VXE25_000312"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001141648.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AzlC family ABC transporter permease"
                     /protein_id="HEV0770839.1"
                     /translation="MPTALGYVSIGLACGTIGAPYVTPVEMGLMSLFVYAGSAQFAML
                     ALIVVQAPVAAIAMTVFLINLRLFLLSLHASTYFRHTSLWYNIGMSSILTDETYGVLM
                     GELAHTDKVNPMWMHGNNLNSYVAWFVGTVVGTALGGLLPNPEIFGLDFALVGMFIGI
                     FASQFQIMQRRIPVRNLLIILAVVAVSFFLLLTVVSQSLAVLFATLLGCSMGVVLDGQ
                     "
     gene            912..1235
                     /locus_tag="VXE25_000313"
     CDS             912..1235
                     /locus_tag="VXE25_000313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000253911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AzlD domain-containing protein"
                     /protein_id="HEV0770840.1"
                     /translation="MVSKYLLLAVIFSGLVTWIPRMILFILVKHKGLPAIVERFLKFL
                     PVSIIFALILSSVVTGKVGSLPQIKWLDFLAVFPTAWVAFRYRNLVGTVLFGVVLIAI
                     LRLVF"
     gene            1339..2169
                     /locus_tag="VXE25_000314"
     CDS             1339..2169
                     /locus_tag="VXE25_000314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="HEV0770841.1"
                     /translation="MKKIVKYSSLAALALVAAGVLAACSGGAKKEGQAASKKEIIVAT
                     NGSPRPFIYEENGELTGYEIEVVRAIFKDSDKYDVKFEKTEWSGVFAGLDADRYNMAV
                     NNLSYTKERAEKYLYAAPIAQNPNVLVVKKDDSSIKSLDDIGGKSTEVVQATTSAKQL
                     EAYNAEHTDNPTILNYTKADFQQIMVRLSDGQFDYKIFDKIGVETVIKNQGLDNLKVI
                     ELPSDQQPYVYPLLAQGQDELKSFVDKRIKELYKDGTLEKLSKQFFGDTYLPAEADIK
                     "
     gene            2323..3177
                     /locus_tag="VXE25_000315"
     CDS             2323..3177
                     /locus_tag="VXE25_000315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000694494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MetQ/NlpA family ABC transporter
                     substrate-binding protein"
                     /protein_id="HEV0770842.1"
                     /translation="MKIKKWLGLAALATVAGLALAACGNSEKKADNATTIKIATVNRS
                     GSEEKRWDKIQELVKKDGITLEFTEFTDYSQPNKATADGEVDLNAFQHYNFLNNWNKE
                     NGKDLVAIADTYISPIRLYSGLNGSANKYTKVEDIPANGEIAVPNDATNESRALYLLQ
                     SAGLIKLDVSGTALATVANIKENPKNLKITELDASQTARSLSSVDAAVVNNTFVTEAK
                     LDYKKALFKEQADENSKQWYNIIVAKKDWETSPKADAIKKVIAAYHTDDVKKVIEESS
                     DGLDQPVW"
     gene            3277..4650
                     /locus_tag="VXE25_000316"
     CDS             3277..4650
                     /locus_tag="VXE25_000316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="HEV0770843.1"
                     /translation="MVFPSEQEQIEKFEKDHVAQHYFEVLRTLISKKSVFAQQVGLKE
                     VANYLGEIFKRVGAEVEIDESYTAPFVMAHFKSSRPDAKTLIFYNHYDTVPADGDQVW
                     TEDPFTLSVRNGFMYGRGVDDDKGHITARLSALRKYMQHHDDLPVNISFIMEGAEESA
                     STDLDKYLEKHADKLRGADLLVWEQGTKNALEQLEISGGNKGIVTFDAKVKSADVDIH
                     SSYGGVVESAPWYLLQALQSLRAADGRILVEGLYEEVQEPNEREMALLETYGQRNPEE
                     VSRIYGLELPLLQEERMAFLKRFFFEPALNIEGIQSGYQGQGVKTILPAEASAKLEVR
                     LVPGLEPHDVLEKIRKQLDKNGFDKVELYYTLGEMSYRSDMSAPAILNVIELAKKFYP
                     QGVSVLPTTAGTGPMHTVFDALEVPMVAFGLGNANSRDHGGDENVRIADYYTHIELVE
                     ELIRSYE"
     gene            4643..5704
                     /locus_tag="VXE25_000317"
     CDS             4643..5704
                     /locus_tag="VXE25_000317"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000085652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine ABC transporter ATP-binding protein"
                     /protein_id="HEV0770844.1"
                     /translation="MSRDIIKLDQIDVTFHQKKRTITAVKDVTIHIQEGDIYGIVGYS
                     GAGKSTLVRVINLLQKPSAGKITIDDDVIFDGKVTLTAEQLRRKRQDIGMIFQHFNLM
                     SQKTAEENVAFALKHSGLSKEEKKAKVAKLLDLVGLADRAENYPSQLSGGQKQRVAIA
                     RALANDPKILISDESTSALDPKTTKQILALLQDLNQKLGLTVVLITHEMQIVKDIANR
                     VAVMQDGHLIEEGSVLEIFSNPKQPLTQDFISTATGIDEAMVKIEKQEIVEHLSENSL
                     LVQLKYAGASTDEPLLNELYKHYQVMANILYGNIEILDGTPVGELVVVLSGEKAALAG
                     AQEAIRQAGVQLKVLKGVQ"
     gene            5706..6398
                     /locus_tag="VXE25_000318"
     CDS             5706..6398
                     /locus_tag="VXE25_000318"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255001.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEV0770845.1"
                     /translation="MESLIQTYLPNVYKMGWAGQAGWGTAIYLTLYMTVLSFIIGGFL
                     GLVAGLFLVLTAPGGVLENKVVFWILDKITSIFRAVPFIILLAILSPLSHLIVKTSIG
                     PNAALVPLSFAVFAFFARQVQVVLAELDGGVIEAAQASGATFWDIVGVYLSEGLPDLI
                     RVTTVTLISLVGETAMAGAVGAGGIGNVAIAYGFNRYNHDVTILATIIIILIIFAIQF
                     LGDFLTKKLSHK"
     gene            complement(6428..6997)
                     /locus_tag="VXE25_000319"
     CDS             complement(6428..6997)
                     /locus_tag="VXE25_000319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000748387.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MptD family putative ECF transporter S
                     component"
                     /protein_id="HEV0770846.1"
                     /translation="MKKSILTTLLFAVLYFLCMGIGVLLGNLFDQTGNMFYAPAFTAL
                     VGGSVYMILVAKVPRFGAITTIGLVIALFFLGTKHGAGSFLPGIICGLLADEVAHLGK
                     YKDKTKNFLSFIIFAFSTTGPILLMWIAPKAYMATLLARGKSQEYIDRIMVAPNPGTV
                     LLFIASIVIGALVGALIGQALSKKFAQKI"
     gene            7132..7746
                     /locus_tag="VXE25_000320"
     CDS             7132..7746
                     /locus_tag="VXE25_000320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000532354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YesL family protein"
                     /protein_id="HEV0770847.1"
                     /translation="MGRFLDFVFNRFFLGMIATAFFWLLTLVGGIILGLAPASATLMS
                     LYAEHGYSFREYSLKEAWSLYKQNFVSSNLIFYSFLGVGLVLTYGLYLLVQLPHQTIV
                     HLIATLLNVLVVALIFLAYTVSLKLQVYFALSYRNSLKLSLIGIFMSLAAVAKILLGT
                     VLLVAIGYYMPALLFFVGIGMWHFFISDMLEPVYEIIHEKLATK"
     gene            7748..9394
                     /locus_tag="VXE25_000321"
     CDS             7748..9394
                     /locus_tag="VXE25_000321"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013670288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEV0770848.1"
                     /translation="MKHFWLHTLLRTYSSVMIIIIASFAILLSYADWDSREKEAQRVA
                     QRVTARTVSEIEYYHRESTQIAQALVENQARIEGIYKYFSLSMPDYFYWQLERKASPY
                     ISVSLYENVDDLYVRNDFVTGVAIAFQDYKEVYVSTKDKRSGEKIRAEDFKPAGNSFA
                     IPVSDPVSDQDLGVIYISLDPAVLYHAIDNTRGHTPMAVTVTSPFDTEIFHIGETVDR
                     ESENWLVGLTSHGYQVQVAVPKNFVLQGTVTSSALIVGLSLLFIVILYLTLRQTFANY
                     QKQVVDLVESIQVIAQGEEGRRIDISEKDQELLLIAETTNDMLDRLEKNIHDIYQLEL
                     SQKDANMRALQAQINPHFMYNTLEFLRMYAVMQSQDELADIIYEFSSLLRNNISDERE
                     TLLKQELEFCRKYSYLCMVRYPKSIAYGFKIDPELENMKIPKFTLQPLVENYFAHGVD
                     HRRTDNVISIKALKQDGFVEILVVDNGRGMSAEKLANIREKLSQRYFEHQASYSDQRQ
                     SIGIVNVHERFVLYFGDRYAITIESAEQAGVQYRITIQDE"
     gene            9406..10692
                     /locus_tag="VXE25_000322"
     CDS             9406..10692
                     /locus_tag="VXE25_000322"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000278884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEV0770849.1"
                     /translation="MYKVLLVDDEYMVTEGLKRLIPFDKWDMEVVATASHADEALEYV
                     QENPVDVIISDVNMPDKTGLDMIREMKEILPDAAYILLSGYQEFDYVKRAMNLSVVDY
                     LVKPVDKVELGNLLEKIAGQLGERGKKSQTLSQELDEAGFVSYLGDKENWWIGLSKEK
                     QGSFTIPYYVLGQDWQIFISGQPLDGLVVTPFEAPYQEHFERWKLNAEKTLFYGSVNL
                     QQSESLFAYYEPIYRVIIQGNLNQIVEELNLLEKVVLENTPRVPITKQLFIQFVMDVF
                     HLFEHLKADDLTDIVKTIHAIQSFDELVSYIKETLISFFGQYRMNENVVSVLEVIGRD
                     YQKELSLKDISKALFINPVYLGQLIKRETDSTFAELLNKQRIKAAQQLLLSTSDSIED
                     ICYAVGYSNLGYFYKVFRKLCGKSPKAYRKQVETIL"
     gene            10744..11277
                     /locus_tag="VXE25_000323"
     CDS             10744..11277
                     /locus_tag="VXE25_000323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEV0770850.1"
                     /translation="MKKKPIYLWVLLILSALISVPSLFGIVSPLPSKEALRAAQKQVA
                     GVNAQQLEDQLNYTYRVAEASHSIFNVALIVLSTILVVVAIVFLVRKNLQYANYTYVG
                     YVLLAIIGSIYGYVGLQDAVQLVQDESMRLTVSIGSKAVSIFYIVINVLFLALVFYKM
                     WRQQKALAEEEETEELA"
     gene            11355..11825
                     /gene="nrdI"
                     /locus_tag="VXE25_000324"
     CDS             11355..11825
                     /gene="nrdI"
                     /locus_tag="VXE25_000324"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000849618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class Ib ribonucleoside-diphosphate reductase
                     assembly flavoprotein NrdI"
                     /protein_id="HEV0770851.1"
                     /translation="MKTISLVYISLSGNTESFVTRLKDYLLSQYKGIEVQKIHIKDLV
                     KEGKNFYEMDHPYVAFLPTYLEGGNGVDNGDVEILTTPVGDFIAYGNNASKCFGVVGS
                     GNRNFNNQYCLTAKQYSQRFGFPVLADFEMRGMLEDIKHVAAIIADLYELEKEN"
     gene            complement(12118..13380)
                     /locus_tag="VXE25_000325"
     CDS             complement(12118..13380)
                     /locus_tag="VXE25_000325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000075801.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="divalent metal cation transporter"
                     /protein_id="HEV0770852.1"
                     /translation="MSQAISLNQSTWASKLKAMGPGILMATAAVGGSHIVSSTQAGGS
                     YGWSLLLLVILANVFKYPFFRFGAEYTADTGKTLVEGYAEKGKLYLWIFFILNVFSAM
                     VNTAGVAILCSAIIASAFPMIGLSITQWSLILVAIIWAMLLFGGYKLLDGMVKWIMSA
                     LTIATVLAVIIAAVKHPEYSSDFVEKTPWQMAALPFIVSLLGWMPAPIEISAINSLWS
                     AEKRKTVNFNTEDAVFDFNTGYIGTAILAVFFVALGALIQYPTGQAVEAASAKYISQF
                     VGMYASVLGEWSRYLITFIAFLCIFGTVITVIDGYSRVNQESLRLLISQKEDNRKSLN
                     IWMTITAIIGIVIIKFFAGQVSTMLRFAMIGSFLTTPFFALLNYALVTRENKNLPSWL
                     KHLAIAGLIFLFGFAIFFIYALAIGKAG"
     gene            complement(13690..14148)
                     /locus_tag="VXE25_000326"
     CDS             complement(13690..14148)
                     /locus_tag="VXE25_000326"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3021 domain-containing protein"
                     /protein_id="HEV0770853.1"
                     /translation="MKKQVFHDAAAGVLIGLILSILFSLIYAPNTYAPLNPYSLIGQV
                     MDQHQVHGALVLLYCTLIWAAIGMLFNFGNRLFSRDWSMLRATLTHFFLMLAGFVPLA
                     TLAGWFPFHWIFYLQLIIEFAIVYLIIWAILYKREAKKVDHINQLLEHRK"
     gene            complement(14145..14585)
                     /locus_tag="VXE25_000327"
     CDS             complement(14145..14585)
                     /locus_tag="VXE25_000327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000861967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEV0770854.1"
                     /translation="MKVELQISETYEEEKLIVQAPQETEKVQKVIEFAENLDQREKIK
                     GKIDDQVYLVEIGKIQRFYIENRKVLAETASQTYSIDLRLYQVLKLLPTNFIQISQSE
                     IINIDSISHLKLTPNGLVEIFLKNESFTYSSRRYLKTIKEKLEL"
     gene            14941..16890
                     /gene="mutL"
                     /locus_tag="VXE25_000328"
     CDS             14941..16890
                     /gene="mutL"
                     /locus_tag="VXE25_000328"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004250478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA mismatch repair endonuclease MutL"
                     /protein_id="HEV0770855.1"
                     /translation="MSHIIELPEMLANQIAAGEVIERPASVVKELVENAIDAGSSQII
                     IEIEEAGLKKVQITDNGHGIAHDEVELALRRHATSKIKNQADLFRIRTLGFRGEALPS
                     IASVSVLTLLTAVDGASHGTKLVARGGEVEEVIPATSPVGTKVCVEDLFFNTPARLKY
                     MKSQQAELSHIIDIVNRLGLAHPEISFSLISDGKEMTRTAGTGQLRQAIAGIYGLVSA
                     KKMIEIENSDLDFEISGFVSLPELTRANRNYISLFINGRYIKNFLLNRAILDGFGSKL
                     MVGRFPLAVIHIHIDPYLADVNVHPTKQEVRISKEKELMTLVSEAIANSLKEQTLIPD
                     ALENLAKSTVRNREKVEQTILPLKENTLYYEKTEPSRPSQTEVADYQVELTDEGQDLT
                     LFAKETLDRLTKPAKLHFAERKPANYDQLDHPELDLASIDKAYDKLEREEASSFPELE
                     FFGQMHGTYLFAQGRDGLYIIDQHAAQERVKYEEYRESIGNVDQSQQQLLVPYIFEFP
                     ADDALRLKERMPLLEEVGVFLAEYGENQFILREHPIWMAEEEIESGIYEMCDMLLLTK
                     EVSIKKYRAELAIMMSCKRSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHF
                     TKSDMEKMFRRIQENHTSLRELGKY"
     gene            complement(17215..17682)
                     /locus_tag="VXE25_000329"
     CDS             complement(17215..17682)
                     /locus_tag="VXE25_000329"
                     /EC_number="2.5.1.78"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001099498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6,7-dimethyl-8-ribityllumazine synthase"
                     /protein_id="HEV0770856.1"
                     /translation="MNTYEGNLVANNIKIGIVVARFNEFITSKLLSGALDNLKRENVN
                     EKDIEVAWVPGAFEIPLIASKMAKSKKYDAIICLGAVIRGNTSHYDYVCSEVSKGIAQ
                     ISLNSEIPVMFGVLTTDTIEQAIERAGTKAGNKGSECAQGAIEMVNLIRTLDA"
     gene            complement(17683..18888)
                     /locus_tag="VXE25_000330"
     CDS             complement(17683..18888)
                     /locus_tag="VXE25_000330"
                     /EC_number="3.5.4.25"
                     /EC_number="4.1.99.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP
                     cyclohydrolase II"
                     /protein_id="HEV0770857.1"
                     /translation="MEYRKIQEALEALQKGRLVLVIDDKDRENEGDLICSAQAATTEN
                     VNFMATYAKGLICMPMSESLANQLMLSPMVENNTDNHKTAFTVSIDYKETTTGISAEE
                     RGLTARMCVAEDITPSDFRRPGHMFPLIAKKGGVLERSGHTEATVDLLKLAGLKECGL
                     CCEIMNHDGKMMRTDDLIQFSKKHNIPLITIKELQEYRKVYDQLVERVSTVNMPTRYG
                     NFKAISYIDKLNGEHHLALIMGNIEDEANVLCRVHSECLTGDVLGSLRCDCGQQFDKA
                     MKMIVENGSGVLLYLRQEGRGIGLINKLKAYHLQDQGMDTLDANLALGFEGDLREYHI
                     GAQMLKDLGLQSLHLLTNNPDKVEQLEKYGITISSRISIEIEANPYDSFYLETKKNRM
                     GHILNMEEK"
     gene            complement(18908..19543)
                     /gene="ribE"
                     /locus_tag="VXE25_000331"
     CDS             complement(18908..19543)
                     /gene="ribE"
                     /locus_tag="VXE25_000331"
                     /EC_number="2.5.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000493842.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="riboflavin synthase"
                     /protein_id="HEV0770858.1"
                     /translation="MFTGIIEEIGKVERIQKDSRNCKLSIKASKILTDIHLGDSIAVN
                     GICLTVTHFNHQSFTVDVMNETWSRTALTLLKHGSEVNLERALSVNGRLGGHVVTGHI
                     DGTGKISSIKKDDNAVWYQINTQKEILDLIVEKGSITIDGISLTVAKVSKVNFSVSVI
                     PHTLEQTILKSKQVGSTVNLENDILGKYVQKLMDNSPKSEISKELLYQNGF"
     gene            complement(19528..20628)
                     /gene="ribD"
                     /locus_tag="VXE25_000332"
     CDS             complement(19528..20628)
                     /gene="ribD"
                     /locus_tag="VXE25_000332"
                     /EC_number="1.1.1.193"
                     /EC_number="3.5.4.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001284110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     diaminohydroxyphosphoribosylaminopyrimidine
                     deaminase/5-amino-6-(5-phosphoribosylamino)uracil
                     reductase RibD"
                     /protein_id="HEV0770859.1"
                     /translation="MSDSKYMKLAIKLAQKGAGYVNPNPMVGAVIVKDNHIIGQGYHE
                     FFGGPHAERNALKNCRESPVGATLYVTLEPCCHFGKTPPCIDAIIDSGITRVVIGSLD
                     CNPIVSGKGVKILEENNLQVTVGILENECLNLIKSFRKYITQHVPYVFMKYAMSMDGK
                     IATKTNQSKWITEEEARKHVQQLRHHVSAIMVGVNTVIQDDPLLTCRLEEGKNPIRII
                     CDTHLRTPLTSKIVKTANDIKTYIATSSEDKNKMKLYQNHGCEILSIKKKGNHIDLSS
                     LMQHLGNMQIDSLVLEGGSLMNWSALEQQIVDELKIYIAPKIFGGSAKFPVGGEGISL
                     PNDAIRLKPYAFSQIGNDYLIESEVIYPCSQE"
     regulatory      complement(20762..20876)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
     gene            21033..21626
                     /gene="ruvA"
                     /locus_tag="VXE25_000333"
     CDS             21033..21626
                     /gene="ruvA"
                     /locus_tag="VXE25_000333"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000271492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction branch migration protein RuvA"
                     /protein_id="HEV0770860.1"
                     /translation="MYAYLKGIITKITAKYIVLETNGIGYILHVANPYAYSGQVNQEA
                     QIYVHQVVREDAHLLYGFRSEDEKKLFLSLISVSGIGPVSALAIIAADDNAGLVQAIE
                     TKNITYLTKFPKIGKKTAQQMVLDLEGKVVVAGDDLPAKVAVQASAENQELEEAMEAM
                     LALGYKATELKKIKKFFEGTTDTAENYIKSALKMLVK"
     gene            21636..22199
                     /locus_tag="VXE25_000334"
     CDS             21636..22199
                     /locus_tag="VXE25_000334"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-3-methyladenine glycosylase I"
                     /protein_id="HEV0770861.1"
                     /translation="MTKRCSWVKMTNPLYIAYHDEEWGQPLHDDQVLFELLCMETYQA
                     GLSWETVLNKRQAFREVFHSYQIHSVAEMTDTELEAMLENPAIIRNRAKLFATRANAQ
                     VFLQLQAEYGSFDAYLWSFVEGKTVVNDVPDYRQAPAKTPLSEKLAKDLKKRGFKFTG
                     PVAVLSFLQAAGLVDDHENDCEWKGLK"
     gene            22196..22873
                     /locus_tag="VXE25_000335"
     CDS             22196..22873
                     /locus_tag="VXE25_000335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000987430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEV0770862.1"
                     /translation="MMSNKNKGILIFAILYTVLFVFDGVKLLASLMPSVIANYLVYVV
                     LALYGSFLFKDRLIQQWKEIRKTKRKFFFGVLTGWLFLILMTVVFEFVSEMLKQFVRL
                     DGQGLNQSNIQSTFQEQPLLIAVFACVIGPLVEELFFRQVLLHYLQERLPGLLSIILV
                     GLVFALTHMHSLALSEWIGAVGYLGGGLAFSIIYVKEKENIYYPLLVHMLSNSLSLII
                     LAISIVK"
     gene            complement(23028..24059)
                     /locus_tag="VXE25_000336"
     CDS             complement(23028..24059)
                     /locus_tag="VXE25_000336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000255096.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LD-carboxypeptidase"
                     /protein_id="HEV0770863.1"
                     /translation="MVSTIGIVSLSSGIIGEDFVKHEVDLGIQRLKDLGLNPIFLPHS
                     LKGLDFIKDHPEARAEDLIHAFSDDSIDMILCAIGGDDTYRLLPYLFENDQLQKVIKQ
                     KIFLGFSDTTMNHLMLHKLGIKTFYGQSFLADICELDKEMLAYSLHYFKELIETGRIS
                     EIRPSDVWYEERTDFSPTALGTPRVSHTNTGFDLLQGSAQFEGKILGGCLESLYDIFD
                     NSRYADSTELCPKYKLFPDLSDWEGKILLLETSEEKPKPEDFKKMLLTLKDTGIFAVI
                     NGLLVGKPMDETFHDDYKEALLDIIDSNIPIVYNLNVGHATPRAIVPFGVHAHVDAQE
                     QVIRFDYNK"
     gene            complement(24314..24997)
                     /locus_tag="VXE25_000337"
     CDS             complement(24314..24997)
                     /locus_tag="VXE25_000337"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000078028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1129 domain-containing protein"
                     /protein_id="HEV0770864.1"
                     /translation="MSQIDLQKLTKKNQEFVHIATQQFIKDGKTDAEIQTIFEEVIPQ
                     ILEEQSKGTTARSLYGAPTHWAHSFTVKEQYEKEHPKENDDPKLMIMDSALFITSLFA
                     LVSALTTFFAADQAFGYGLITLLLVGLVGGFAFYLMYYFVYQYYGPDMDRSQRPPFWK
                     SVLVILASMFLWLLVFFATSFLPASLNPVLDPLPLAIIGAALLALRFYLKKRLNIRSA
                     SAGPTRYQE"
     gene            complement(25009..25953)
                     /locus_tag="VXE25_000338"
     CDS             complement(25009..25953)
                     /locus_tag="VXE25_000338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004250490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="magnesium transporter CorA family protein"
                     /protein_id="HEV0770865.1"
                     /translation="MKQVFLSTTTEFKEIDTLEPGTWINLVNPTQNESLEIANTFDID
                     IADLRAPLDAEEMSRITIEDEYTLIIVDVPVTEERNNRTYYVTIPLGIIITEETIITT
                     CLEPLPVLDVFINRRLRNFYTFMRSRFIFQILYRNAELYLTALRSIDRKSEQIESQLH
                     QSTRNEELIELMELEKTIVYFKASLKTNERVIKKLTSSTSNIKKYLEDEDLLEDTLIE
                     TQQAIEMADIYGNVLHSMTETFASIISNNQNNIMKTLALVTIVMSIPTMVFSAYGMNF
                     KDNEIPLNGEPNAFWLIVFIAFAMSVSLTLYLIHKKWF"
     gene            26085..28916
                     /gene="uvrA"
                     /locus_tag="VXE25_000339"
     CDS             26085..28916
                     /gene="uvrA"
                     /locus_tag="VXE25_000339"
                     /EC_number="3.1.25.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="HEV0770866.1"
                     /translation="MQDKIVIHGARAHNLKNIDVEIPRDKLVVVTGLSGSGKSSLAFD
                     TLYAEGQRRYVESLSAYARQFLGNMEKADVDAIDGLSPAISIDQKTTSKNPRSTVGTT
                     TEINDYLRLLYARVGTPYCINGHGAINASSVEQIVDKVLELPERQRLQILAPVIRKKK
                     GQHKSVIEKVQKDGYVRVRVDGEVYDVTEVPELSKSKQHNIDVVVDRIVIKEGIRSRL
                     FDSIEAALRIAEGYVIIDTMDDSELLFSEHYACPVCGFTVPELEPRLFSFNAPFGSCS
                     ECDGLGIKLEVDTDLVVPDASKTLREGALAPWNPISSNYYPNMLEQAMKVFGVAMDKP
                     FEDLSEEDKNLILYGSDGKEFHFHYENEFGGVRDIDIPFEGVINNIKRRYHETNSDYT
                     RTQMRLYMNELTCGTCQGYRLNDQALSVRVGGQQGPHIGEISDLSIADHLDLVSQLTL
                     SENEAIIARPILKEIKDRLTFLNNVGLNYLTLSRSAGTLSGGESQRIRLATQIGSNLS
                     GVLYILDEPSIGLHQRDNDRLIASLKKMRDLGNTLIVVEHDEDTMREADYLIDVGPGA
                     GVFGGEIVAAGTPKQVARNSKSITGQYLSGKRVIPVPEERRVGNGRFIEVIGARENNL
                     QNVTARFPLGKFIAVTGVSGSGKSTLINSILKKAIAQKLNRNSDKPGKFKTITGIEHV
                     DRLIDIDQSPIGRTPRSNPATYTGVFDDIRDLFAQTNEAKIRGYKKGRFSFNVKGGRC
                     EACSGDGIIKIEMHFLPDVYVACEVCHGTRYNSETLEVHYKEKNISQVLDMTVNDAVE
                     FFQHIPKIQRKLQTIKDVGLGYVTLGQPATTLSGGEAQRMKLASELHKRSTGKSFYIL
                     DEPTTGLHTEDIARLLKVLARFVDDGNTVLVIEHNLDVIKTADHIIDLGPEGGVGGGT
                     IIVTGTPEEVAANEASYTGHYLKGKLHHE"
     gene            28909..29970
                     /locus_tag="VXE25_000340"
     CDS             28909..29970
                     /locus_tag="VXE25_000340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HEV0770867.1"
                     /translation="MNKRVQAFLAKMQEKELDGIIINNLKNVYYLTGFWGSNGTVFIS
                     RDRQVLVTDSRYIIAAKQETSGFEIVADRDELAVIAGIVKDMGLTRIGFEDEISVSYY
                     HRMQAAFAGLDLLPQTQFVEGLRMIKDEAEIAAIRKACSISDQAFRDALDFIKPGKTE
                     IEIANFLDFRMRELGASSLSFDTILASGINSSKPHAHPMHKPVELGEAITMDFGCLYD
                     HYVSDMTRTIYLGHVSDEQAEIYNTVLKANQALIDQAKAGLGFRDFDKIPRDIIIEAG
                     YGDYFTHGIGHGIGLDIHEEPYFSQTSTETIKTGMALTDEPGIYIEGKYGVRIEDDIL
                     ITETGCELLTLAPKELIVI"
     gene            30102..30500
                     /gene="spx"
                     /locus_tag="VXE25_000341"
     CDS             30102..30500
                     /gene="spx"
                     /locus_tag="VXE25_000341"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017768833.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator Spx"
                     /protein_id="HEV0770868.1"
                     /translation="MIKIYTVSSCTSCKKAKTWLNAHQLSYKEQNLGKEGITREELLD
                     ILTKTDNGIASIVSSKNRYAKALGVDIEDLSVNEVLNLIMETPRILKSPILVDEKRLQ
                     VGYKEDDIRAFLPRSVRNVENAEARLRAAL"
     gene            30566..31135
                     /locus_tag="VXE25_000342"
     CDS             30566..31135
                     /locus_tag="VXE25_000342"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HEV0770869.1"
                     /translation="MKKIVLVSLAFLFVLVGCGQKKETGTATKTEKDTLQSALPVIEN
                     AEKNTVVTKTLVLPKSDDGSQQTQTITYKDKTFLSLTIQQKRPVSDELKIYIDQHGVE
                     ETQKALLEAEEKDKSIIEARKLAGFKLETKLLSATELQTTTSFDFQVLDVKKASQLEH
                     LKNIGLENLLKNEPSKYISDRLANGATEQ"
     gene            31222..31488
                     /locus_tag="VXE25_000343"
     CDS             31222..31488
                     /locus_tag="VXE25_000343"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004250500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IreB family regulatory phosphoprotein"
                     /protein_id="HEV0770870.1"
                     /translation="MGFTEETVRFKLDDSNKKEISETLTDVYASLNDKGYNPINQIVG
                     YVLSGDPAYVPRYNNARNQIRKYERDEIVEELVRYYLKGQGVDL"
     gene            31492..31911
                     /gene="ruvX"
                     /locus_tag="VXE25_000344"
     CDS             31492..31911
                     /gene="ruvX"
                     /locus_tag="VXE25_000344"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002939356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction resolvase RuvX"
                     /protein_id="HEV0770871.1"
                     /translation="MRIMGLDVGSKTVGVAISDPLGFTAQGLEIIQINEEQGQFGFDR
                     VKELVDTYKVERFVVGLPKNMNNTSGPRVEASQAYGAKLEEFFGLPVDYQDERLTTVA
                     AERMLIEQADISRNKRKKVIDKLAAQLILQNYLDRKF"
     gene            31927..32232
                     /locus_tag="VXE25_000345"
     CDS             31927..32232
                     /locus_tag="VXE25_000345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1292 domain-containing protein"
                     /protein_id="HEV0770872.1"
                     /translation="MSHDHNHDHEERELITLVDEQGNETLFEILLTIDGKEEFGKNYV
                     LLVPVNAEEDEDGQVEIQAYSFIENEDGTEGELQPIPEDSEDEWNMIEEVFNSFMEE"
     gene            32487..33737
                     /locus_tag="VXE25_000346"
     CDS             32487..33737
                     /locus_tag="VXE25_000346"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000464354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional folylpolyglutamate
                     synthase/dihydrofolate synthase"
                     /protein_id="HEV0770873.1"
                     /translation="MFEVEEWLHSRIGLNFRSGLGRMQQAVDLLGNPEQSYPIIHVTG
                     TNGKGSTIAFMRELFMGHGKKVATFTSPHIVSINDRICINGQPIADADFIRLTDQVKE
                     MEKTLLQTPAQLSFFELLTLVAFLYFREQEVDLVLLEVGIGGLLDTTNVVTGELAVIT
                     SIGLDHQETLGDSLEAIAEQKAGIFKAGKKAVIAKLPPEARLVCQKKAESLAVNLYQA
                     GQDFLMLNGDFSSSLLNLSQLNIGLEGVYQQENAALALQTFLLFMGEGKEAVDEQAVR
                     KALEQTHWAGRLERIRPQIYLDGAHNLPALTRLVEFIKEKEQEGYRPQILFGALKRKD
                     YQGMLGYLTEKLPQVELKVTGFDYQGALDERDVTGYDIVSSYREFISDFEERADAQDL
                     LFVTGSLYFISEVRGYLLDREQIN"
     gene            33734..34252
                     /locus_tag="VXE25_000347"
     CDS             33734..34252
                     /locus_tag="VXE25_000347"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001816192.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipocalin/fatty acid-binding family protein"
                     /protein_id="HEV0770874.1"
                     /translation="MTPLFELVILGELLVRENFSKLVAERKFIMKLKRFTLSLASLAS
                     FSLLVACSQRAQQVQQPAQQNTNTANAGGNQNQAAPVQNQPVAQPTDIDGTYTGQDDG
                     DRITLVVTGTTGTWTELESDGDQKVKQVTFDSANQRMIIGDDVKIYTVNGNQIVVDDM
                     DRDPSDQIVLTK"
     gene            34398..35930
                     /gene="cls"
                     /locus_tag="VXE25_000348"
     CDS             34398..35930
                     /gene="cls"
                     /locus_tag="VXE25_000348"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000877342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cardiolipin synthase"
                     /protein_id="HEV0770875.1"
                     /translation="MKYRKFQLLMSKYGFSLSIMLLELCLVFGLFLYLGRMAPILWIT
                     VLILLSIITIISIVNRNTTPENKVTWLLVAFVPVFGPLLYLMFGERRLSKKEIKQLKK
                     LGSMHFQEANSQLLKEKLKESDKAAYGVIKSLLSMDTNADIYDQTASTFFPNGEAMWK
                     KMVEDLKKAEKFIFLEYYIIEEGLMWNRILDILEQKVAQGVEVKMLYDDIGCMATLTG
                     DYAHRLRQLGIEAHKFNKVIPRLTVAYNNRDHRKILIVDGQIAYTGGVNLADEYINHV
                     ERFGYWKDSGIRLDGLAVKALTRLFLTTWYINRGEISDFDQYHLENHSIPSDGLTIPY
                     GSGPKPIFRAQVGKKVYQSLINQATESVYITTPYLIIDYDLTETIKNAAMRGVDVRII
                     TPYIPDKKFIQLVTRGAYPDLLSAGVRIYEYSPGFIHSKQMLVDEDFAVVGTINLDYR
                     SLVHHYENAVLLYKTPSIREIARDFRNIFADSQEVYPHSIKTSWYQKLVKEIAQLFAP
                     IL"
     gene            36188..37726
                     /locus_tag="VXE25_000349"
     CDS             36188..37726
                     /locus_tag="VXE25_000349"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844448.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="damage-inducible protein CinA"
                     /protein_id="HEV0770876.1"
                     /translation="MSVYGRVEEVHKENREPLEYQIEQESHHRESSRLPLVKILLWST
                     LVTGITLGVPLLLDLMSAQEVQDFYAGWALHQTGKIYSDYYGSQGLLYYLLTYVSQGG
                     FFFAIFEWLALVAGGFFLFRSADTLTEQGDQAGHLVTIFYMLVTGLAFGGGYATLLAL
                     PFLFAAFSLVAAYLSNPSHDKGFVRIGLALAGGFFFAPLSSLLFIAVVSLGLLVFNLG
                     HRRFVHGFYQFLAVALGFSLVFYPTAYYSAATGSFGDAISGIRYPIDSIRFDFTSKIL
                     ENMFFYGLLSLGLGFVVCIFLGLFQSKPFKLYVISVPASLVVILGLILLFFSQEPLHA
                     SYLMVVFPVFLLLLVTNIKSQQRGRSARRSRRETPVSLWSRFFKGNLYLLVFGFVYLL
                     SVPFLMKFVLYPVPYQERNRLADLVKEETNTEDAIYAWDDTATLYRKSERLSPSAILS
                     PLHYTATEENRNKLLNDLKEKQPKVIVVNDKVVVWSEVETLLKENYQQVKTDYSEFKV
                     YKIK"
     gene            37846..40053
                     /gene="nrdD"
                     /locus_tag="VXE25_000350"
     CDS             37846..40053
                     /gene="nrdD"
                     /locus_tag="VXE25_000350"
                     /EC_number="1.17.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004239081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic ribonucleoside-triphosphate reductase"
                     /protein_id="HEV0770877.1"
                     /translation="MIALEEKITILPTLFVEKRDGRRVVFDVDKIDKALHKAADKVMD
                     VTPLVEKRLNDLTERIITEIHSRFPQGIKIYEIQNIVEHELLEAKEYALAEEYITYRT
                     QRDFERSKATDINFSIHKLLNKDQTVVNENANKDSDVFNTQRDLTAGIVGKSIGLQML
                     PKHVANAHQKGDIHYHDLDYSPYTPMTNCCLIDFKGMLENGFKIGNAEVESPKSIQTA
                     TAQISQIIANVASSQYGGCSADRIDEILAPYAEKNYQKHLKDAEEWVLPEKREDYAWK
                     KTQKDIYDAMQSLEYEINTLFTSNGQTPFTSLGFGLGTSRFEREIQKAILNIRIKGLG
                     SEHRTAIFPKLIFTLKRGLNLEEGTPNYDIKQLALECATKRMYPDVLSYDKIVDLTGS
                     FKVPMGCRSFLQGWKDENGVEVNSGRMNLGVVTVNLPRIALESEGDMNKFWEIFNERM
                     NIAEDALVYRVERTKEATPANAPILYQYGAFGHRLGKEESVDQLFKNRRATVSLGYIG
                     LYEVATVFFGNSWESNPDAKEFTLDIIHDMKRRVEEWSDQYGYHFSIYSTPSESLTDR
                     FCRLDIDKFGSIPDITDKEYYTNSFHYDVRKNPTPFEKLDFEKVYPEAGASGGFIHYC
                     EYPVLQQNPKALEAVWDYAYDRVGYLGTNTPIDRCYKCDFEGDFEPTERGFACPNCGN
                     SDPKTVDVVKRTCGYLGNPQARPMVNGRHKEIAARVKHMNGSTIKIAGHQVTN"
     gene            40065..40205
                     /locus_tag="VXE25_000351"
     CDS             40065..40205
                     /locus_tag="VXE25_000351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000521630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0770878.1"
                     /translation="MGKYQLDDKGRAQVTRYHEKYSKGGAGKKERLLSFREQFLNKNK
                     KK"
     gene            40249..40755
                     /locus_tag="VXE25_000352"
     CDS             40249..40755
                     /locus_tag="VXE25_000352"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000423398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0770879.1"
                     /translation="MELRRPRLADKKAVLDMMTEFEKSQSAHDGGFWDTENFVYEEWL
                     ESNQEQEMGINLPEGWVPAIQLVAFSEKGQAVGFLNLRLRLSNFLLEEGGHIGYSIRP
                     SERGKGYAKETLRQGLQVAKEKNIKKALVTCSVNNPASRAVILANGGIFEDARNGVER
                     YWIEVANE"
     gene            40748..41338
                     /gene="nrdG"
                     /locus_tag="VXE25_000353"
     CDS             40748..41338
                     /gene="nrdG"
                     /locus_tag="VXE25_000353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001064213.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic ribonucleoside-triphosphate reductase
                     activating protein"
                     /protein_id="HEV0770880.1"
                     /translation="MNNPKPQEWKSEELSQGRIIDYKAFNFVDGEGVRNSLYVAGCMF
                     HCEGCYNVATWSFNAGIPYTAELEEQIMADLAQPYVQGLTLLGGEPFLNTGILLPLVK
                     RIRKELSDKDIWSWTGYTWEEMMLETPDKLELLSLIDILVDGRYDRTKRNLMLQFRGS
                     SNQRIIDVQKSLKSGQVVIWDKLNDGKESYEQVKRE"
     gene            41335..41970
                     /locus_tag="VXE25_000354"
     CDS             41335..41970
                     /locus_tag="VXE25_000354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribulokinase"
                     /protein_id="HEV0770881.1"
                     /translation="MKKKDLVDQLVSEIETGKVRTLGIYGHGASGKSTLAQELSQALD
                     STTVNLSTTVNLLETDPYITSGRYLVVPKDAPNQKVTASLPVAYELESLQRDILALQA
                     GMDVLTIEEPWKASEVLSGAKPILIVEGMSVGFLPKELFEKTICFYTDEETELKRRFA
                     RDTTVRNRDASFILASHQMRREQYLRYYKETESKADILVDQSEDKFDVKRT"
     gene            42225..42533
                     /gene="rpsJ"
                     /locus_tag="VXE25_000355"
     CDS             42225..42533
                     /gene="rpsJ"
                     /locus_tag="VXE25_000355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003046044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S10"
                     /protein_id="HEV0770882.1"
                     /translation="MANKKIRIRLKAYEHRTLDTAAAKIVESATRTGAQVAGPIPLPT
                     ERSLYTIIRATHKYKDSREQFEMRTHKRLIDIVNPTQKTVDALMKLDLPSGVNVEIKL
                     "
     gene            42749..43375
                     /gene="rplC"
                     /locus_tag="VXE25_000356"
     CDS             42749..43375
                     /gene="rplC"
                     /locus_tag="VXE25_000356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L3"
                     /protein_id="HEV0770883.1"
                     /translation="MTKGILGKKVGMTQIFTEAGELIPVTVIEATPNVVLQVKTVETD
                     GYNAIQVGFDDKREVLSNKPAKGHVAKANTAPKRFIREFKNVEGLEVGAEITVETFAA
                     GDVVDVTGTSKGKGFQGVIKRHGQSRGPMAHGSRYHRRPGSMGPVAPNRVFKGKNLAG
                     RMGGDRVTIQNLEVVQVVPEKNVILIKGNVPGAKKSLITIKSAVKAGK"
     gene            43400..44023
                     /gene="rplD"
                     /locus_tag="VXE25_000357"
     CDS             43400..44023
                     /gene="rplD"
                     /locus_tag="VXE25_000357"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L4"
                     /protein_id="HEV0770884.1"
                     /translation="MANVTLFDQTGKEAGQVVLSDAVFGIEPNESVVFDVIISQRASL
                     RQGTHAVKNRSAVSGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYGYKLP
                     QKVRRLALKSVYSEKVAENKFVAVDALSFTAPKTAEFAKVLAALSIDSKVLVILEEGN
                     EFAALSARNLPNVKVATATTASVLDIANSDKLLVTQAAISKIEEVLA"
     gene            44023..44319
                     /locus_tag="VXE25_000358"
     CDS             44023..44319
                     /locus_tag="VXE25_000358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007518994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L23"
                     /protein_id="HEV0770885.1"
                     /translation="MNLYDVIKKPVITESSMAQLEAGKYVFEVDTRAHKLLIKQAVEA
                     AFEGVKVANVNTINVKPKAKRVGRYTGFTNKTKKAIITLTADSKAIELFAAEAE"
     gene            44337..45170
                     /gene="rplB"
                     /locus_tag="VXE25_000359"
     CDS             44337..45170
                     /gene="rplB"
                     /locus_tag="VXE25_000359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019790357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L2"
                     /protein_id="HEV0770886.1"
                     /translation="MGIRVYKPTTNGRRNMTSLDFAEITTSTPEKSLLVALKSKAGRN
                     NNGRITVRHQGGGHKRFYRLVDFKRNKDNVEAVVKTIEYDPNRSANIALVHYTDGVKA
                     YIIAPKGLEVGQRIVSGPEADIKVGNALPLANIPVGTLIHNIELKPGRGGELVRAAGA
                     SAQVLGSEGKYVLVRLQSGEVRMILGTCRATVGVVGNEQHGLVNLGKAGRSRWKGIRP
                     TVRGSVMNPNDHPHGGGEGKAPVGRKAPSTPWGKPALGLKTRNKKAKSDKLIVRRRNE
                     K"
     gene            45274..45555
                     /gene="rpsS"
                     /locus_tag="VXE25_000360"
     CDS             45274..45555
                     /gene="rpsS"
                     /locus_tag="VXE25_000360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000533767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S19"
                     /protein_id="HEV0770887.1"
                     /translation="MGRSLKKGPFVDEHLMKKVEAQANDEKKKVIKTWSRRSTIFPSF
                     IGYTIAVYDGRKHVPVYIQEDMVGHKLGEFAPTRTYKGHAADDKKTRRK"
     gene            45567..45911
                     /gene="rplV"
                     /locus_tag="VXE25_000361"
     CDS             45567..45911
                     /gene="rplV"
                     /locus_tag="VXE25_000361"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L22"
                     /protein_id="HEV0770888.1"
                     /translation="MAEITSAKAMARTVRVSPRKSRLVLDNIRGKSVADAIAILTFTP
                     NKAAEIILKVLNSAVANAENNFGLDKANLVVSEAFANEGPTMKRFRPRAKGSASPINK
                     RTAHITVAVAEK"
     gene            45924..46577
                     /gene="rpsC"
                     /locus_tag="VXE25_000362"
     CDS             45924..46577
                     /gene="rpsC"
                     /locus_tag="VXE25_000362"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000529931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S3"
                     /protein_id="HEV0770889.1"
                     /translation="MGQKVHPIGMRVGIIRDWDAKWYAEKEYADYLHEDLAIRKFVQK
                     ELADAAVSTIEIERAVNKVNVSLHTAKPGMVIGKGGANVDALRAKLNKLTGKQVHINI
                     IEIKQPDLDAHLVGEGIARQLEQRVAFRRAQKQAIQRAMRAGAKGIKTQVSGRLNGAD
                     IARAEGYSEGTVPLHTLRADIDYAWEEADTTYGKLGVKVWIYRGEVLPARKNTKGGK"
     gene            46581..46994
                     /gene="rplP"
                     /locus_tag="VXE25_000363"
     CDS             46581..46994
                     /gene="rplP"
                     /locus_tag="VXE25_000363"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003029477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L16"
                     /protein_id="HEV0770890.1"
                     /translation="MLVPKRVKHRREFRGKMRGEAKGGKEVAFGEYGLQATTSHWITN
                     RQIEAARIAMTRYMKRGGKVWIKIFPHKSYTAKAIGVRMGSGKGAPEGWVAPVKRGKV
                     MFEIAGVSEEIAREALRLASHKLPVKCKFVKREAE"
     gene            47004..47210
                     /locus_tag="VXE25_000364"
     CDS             47004..47210
                     /locus_tag="VXE25_000364"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006739716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L29"
                     /protein_id="HEV0770891.1"
                     /translation="MKLNEVKEFVKELRGLSQEELAKRENELKKELFELRFQAATGQL
                     EQTARLKEVKKQIARIKTVQSEAK"
     gene            47235..47495
                     /gene="rpsQ"
                     /locus_tag="VXE25_000365"
     CDS             47235..47495
                     /gene="rpsQ"
                     /locus_tag="VXE25_000365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006738952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S17"
                     /protein_id="HEV0770892.1"
                     /translation="MERNNRKVLVGRVVSDKMDKTITVVVETKRNHPVYGKRINYSKK
                     YKAHDENNVAKEGDIVRIMETRPLSATKRFRLVEVVEEAVII"
     gene            47521..47889
                     /gene="rplN"
                     /locus_tag="VXE25_000366"
     CDS             47521..47889
                     /gene="rplN"
                     /locus_tag="VXE25_000366"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012727667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L14"
                     /protein_id="HEV0770893.1"
                     /translation="MIQTETRLKVADNSGAREILTIKVLGGSGRKFANIGDVIVASVK
                     QATPGGAVKKGDVVKAVIVRTKSGARRADGSYIKFDENAAVIIREDKTPRGTRIFGPV
                     ARELREGGFMKIVSLAPEVL"
     gene            47967..48272
                     /gene="rplX"
                     /locus_tag="VXE25_000367"
     CDS             47967..48272
                     /gene="rplX"
                     /locus_tag="VXE25_000367"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011921687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L24"
                     /protein_id="HEV0770894.1"
                     /translation="MFVKKGDKVRVIAGKDKGTEAVVLTALPKVNKVIVEGVNIVKKH
                     QRPTNELPQGGIIEKEAAIHVSNVQVLDKNGVAGRVGYKFVDGKKVRYNKKSGEVLD"
     gene            48296..48838
                     /gene="rplE"
                     /locus_tag="VXE25_000368"
     CDS             48296..48838
                     /gene="rplE"
                     /locus_tag="VXE25_000368"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018376779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L5"
                     /protein_id="HEV0770895.1"
                     /translation="MANRLKEKYLNEVVPALTEQFNYSSVMAVPKVDKIVLNMGVGEA
                     VSNAKSLEKAAEELALISGQKPLITKAKKSIAGFRLREGVAIGAKVTLRGERMYEFLD
                     KLVSVSLPRVRDFHGVPTKSFDGRGNYTLGVKEQLIFPEINFDDVDKTRGLDIVIVTT
                     ANTDEESRALLTGLGMPFAK"
     gene            48856..49125
                     /gene="rpsN"
                     /locus_tag="VXE25_000369"
     CDS             48856..49125
                     /gene="rpsN"
                     /locus_tag="VXE25_000369"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006738440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S14"
                     /protein_id="HEV0770896.1"
                     /translation="MAKKSMVAREAKRQKIVDRYAEKRAALKAAGDYEGLSKLPRNAS
                     PTRLHNRCRVTGRPHSVYRKFGLSRIAFRELAHKGQIPGVTKASW"
     gene            49410..49808
                     /gene="rpsH"
                     /locus_tag="VXE25_000370"
     CDS             49410..49808
                     /gene="rpsH"
                     /locus_tag="VXE25_000370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009754342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S8"
                     /protein_id="HEV0770897.1"
                     /translation="MVMTDPIADFLTRIRNANQAKHEVLEVPASNIKKGIAEILKREG
                     FVKNVEIIEDDKQGVIRVFLKYGSNGEKVITNLKRVSKPGLRVYKKREDLPKVLNGLG
                     IAILSTSEGLLTDKEARQKNVGGEVIAYVW"
     gene            50000..50536
                     /gene="rplF"
                     /locus_tag="VXE25_000371"
     CDS             50000..50536
                     /gene="rplF"
                     /locus_tag="VXE25_000371"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L6"
                     /protein_id="HEV0770898.1"
                     /translation="MSRIGNKVIVLPAGVELANNDNVVTVKGPKGELTREFSKDIEIR
                     VEGTEITLHRPNDSKEMKTIHGTTRALLNNMVVGVSEGFKKELEMRGVGYRAQLQGSK
                     LVLAVGKSHPDEVEAPEGITFELPNPTTIVVSGISKEVVGQTAAYVRSLRSPEPYKGK
                     GIRYVGEFVRRKEGKTGK"
     gene            50620..50976
                     /gene="rplR"
                     /locus_tag="VXE25_000372"
     CDS             50620..50976
                     /gene="rplR"
                     /locus_tag="VXE25_000372"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018374469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L18"
                     /protein_id="HEV0770899.1"
                     /translation="MISKPDKNKLRQKRHRRVRGKLSGTADRPRLNVFRSNTGIYAQV
                     IDDVAGVTLASASTLDKEVSKGTKTEQAVAVGKLVAERANAKGISEVVFDRGGYLYHG
                     RVKALADAARENGLKF"
     gene            50994..51488
                     /gene="rpsE"
                     /locus_tag="VXE25_000373"
     CDS             50994..51488
                     /gene="rpsE"
                     /locus_tag="VXE25_000373"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018376782.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S5"
                     /protein_id="HEV0770900.1"
                     /translation="MAFKDNAVELEERVVAVNRVTKVVKGGRRLRFAALVVVGDHNGR
                     VGFGTGKAQEVPEAIRKAVDDAKKNLIEVPMVGTTIPHEVLSEFGGAKVLLKPAVEGS
                     GVAAGGAVRAVVELAGVADITSKSLGSNTPINIVRATVEGLKQLKRAEEIAALRGISV
                     SDLA"
     gene            51460..51684
                     /gene="rpmD"
                     /locus_tag="VXE25_000374"
     CDS             51460..51684
                     /gene="rpmD"
                     /locus_tag="VXE25_000374"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012386624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L30"
                     /protein_id="HEV0770901.1"
                     /translation="MVFQFLIWHKKGDKMAQIKITLTKSPIGRIPSQRKTVVALGLGK
                     LNSSVIKEDNAAIRGMITAVSHLVTVEEVN"
     gene            51829..52269
                     /gene="rplO"
                     /locus_tag="VXE25_000375"
     CDS             51829..52269
                     /gene="rplO"
                     /locus_tag="VXE25_000375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004225266.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L15"
                     /protein_id="HEV0770902.1"
                     /translation="MKLHELKPAEGSRKVRNRVGRGTSSGNGKTSGRGQKGQKARSGG
                     GVRLGFEGGQTPLFRRLPKRGFTNINAKEYAIVNLDQLNVFEDGAEVTPVVLIEAGIV
                     KAEKSGIKILGNGELTKKLTVKAAKFSKSAEEAITAKGGSVEVI"
     gene            52282..53592
                     /gene="secY"
                     /locus_tag="VXE25_000376"
     CDS             52282..53592
                     /gene="secY"
                     /locus_tag="VXE25_000376"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecY"
                     /protein_id="HEV0770903.1"
                     /translation="MFFKLLREALKVKQVRSKILFTIFIVLVFRIGTSITVPGVNANS
                     LNALSGLSFLNMLSLVSGNALKNFSIFALGVSPYITASIVVQLLQMDILPKFVEWGKQ
                     GEVGRRKLNQATRYIALVLAFVQSIGITAGFNTLAGAQLIKTALTPQVFLTIGIILTA
                     GSMIVTWLGEQITDKGYGNGVSMIIFAGIVSSIPEMIQGIYVDYFVNVPSSRITSSII
                     FVIILIITVLLIIYFTTYVQQAEYKIPIQYTKVAQGAPSSSYLPLKVNPAGVIPVIFA
                     SSITAAPAAILQFLSATGHDWAWVRVAQEMLATTSPTGIAMYALLIILFTFFYTFVQI
                     NPEKAAESLQKSGAYIHGVRPGKGTEEYMSKLLRRLATVGSLFLGVISILPIAAKDVF
                     GLSDVVAFGGTSLLIIISTGIEGIKQLEGYLLKRKYVGFMDRTE"
     gene            53743..54381
                     /locus_tag="VXE25_000377"
     CDS             53743..54381
                     /locus_tag="VXE25_000377"
                     /EC_number="2.7.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001050429.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylate kinase"
                     /protein_id="HEV0770904.1"
                     /translation="MNLLIMGLPGAGKGTQAAKIVEQFHVAHISTGDMFRAAMANQTE
                     MGVLAKSYIDKGELVPDEVTNGIVKERLSQDDIKETGFLLDGYPRTIEQAHALDKTLA
                     ELGIELEGVINIEVNPDSLLERLSGRIIHRVTGETFHKVFNPPVDYKEEDYYQREDDK
                     PETVKRRLDVNIAQGEPIIAHYRAKGLVHDIEGNQDINDVFSDIEKVLTNLK"
     gene            54498..54716
                     /gene="infA"
                     /locus_tag="VXE25_000378"
     CDS             54498..54716
                     /gene="infA"
                     /locus_tag="VXE25_000378"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003130554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-1"
                     /protein_id="HEV0770905.1"
                     /translation="MAKDDVIEVEGKVVDTMPNAMFTVELENGHQILATVSGKIRKNY
                     IRILAGDRVTVEMSPYDLTRGRITYRFK"
     gene            54741..54857
                     /gene="rpmJ"
                     /locus_tag="VXE25_000379"
     CDS             54741..54857
                     /gene="rpmJ"
                     /locus_tag="VXE25_000379"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013773089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L36"
                     /protein_id="HEV0770906.1"
                     /translation="MKVRPSVKPICEYCKVIRRNGRVMVICPANPKHKQRQG"
     gene            54875..55240
                     /gene="rpsM"
                     /locus_tag="VXE25_000380"
     CDS             54875..55240
                     /gene="rpsM"
                     /locus_tag="VXE25_000380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S13"
                     /protein_id="HEV0770907.1"
                     /translation="MARIAGVDIPNDKRVVISLTYVYGIGLATSKKILAAAGISEDVR
                     VRDLTSDQEDAIRREVDAIKVEGDLRREVNLNIKRLMEIGSYRGIRHRRGLPVRGQNT
                     KNNARTRKGKAVAIAGKKK"
     gene            55258..55641
                     /gene="rpsK"
                     /locus_tag="VXE25_000381"
     CDS             55258..55641
                     /gene="rpsK"
                     /locus_tag="VXE25_000381"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003130556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S11"
                     /protein_id="HEV0770908.1"
                     /translation="MAKPTRKRRVKKNIESGIAHIHATFNNTIVMITDVHGNAIAWSS
                     AGALGFKGSRKSTPFAAQMASEAAAKSAQEHGLKSVEVTVKGPGSGRESAIRALAAAG
                     LEVTAIRDVTPVPHNGARPPKRRRV"
     gene            55684..56619
                     /locus_tag="VXE25_000382"
     CDS             55684..56619
                     /locus_tag="VXE25_000382"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000568977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit alpha"
                     /protein_id="HEV0770909.1"
                     /translation="MIEFEKPNITKIDENKDYGKFVIEPLERGYGTTLGNSLRRVLLA
                     SLPGAAVTSINIDGVLHEFDTVPGVREDVMQIILNIKGIAVKSYVEDEKIIELDVEGP
                     AEVTAGDILTDSDIEIVNPDHYLFTIGEGSSLKATMTVNSGRGYVPADENKKDNAPVG
                     TLAVDSIYTPVTKVNYQVEPARVGSNDGFDKLTLEILTNGTIIPEDALGLSARILTEH
                     LDLFTNLTEIAKSTEVMKEADTESDDRILDRTIEELDLSVRSYNCLKRAGINTVHDLT
                     EKSEAEMMKVRNLGRKSLEEVKLKLIDLGLGLKDK"
     gene            56631..57017
                     /gene="rplQ"
                     /locus_tag="VXE25_000383"
     CDS             56631..57017
                     /gene="rplQ"
                     /locus_tag="VXE25_000383"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002887523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L17"
                     /protein_id="HEV0770910.1"
                     /translation="MAYRKLGRTSSQRKAMLRDLTTDLLINESIVTTEARAKEIRKTV
                     EKMITLGKRGDLHARRQAAAFVRNEIASENYDEATDKYTSTTALQKLFSEIAPRYAER
                     NGGYTRILKTEPRRGDAAPMAIIELV"
     gene            57282..57548
                     /locus_tag="VXE25_000384"
     CDS             57282..57548
                     /locus_tag="VXE25_000384"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002905356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACT domain-containing protein"
                     /protein_id="HEV0770911.1"
                     /translation="MKAIITVVGKDKSGIVAGVSGKIAELGLNIDDISQTVLDEYFTM
                     MAVVSSDEKQDFTYLRNEFEAFGQTLNVKINIQSAAIFEAMYNI"
     gene            57558..58895
                     /locus_tag="VXE25_000385"
     CDS             57558..58895
                     /locus_tag="VXE25_000385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018166727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PFL family protein"
                     /protein_id="HEV0770912.1"
                     /translation="MDIRQVTETIAMIEEQNFDIRTITMGISLLDCIDPNINRAAEKI
                     YQKITTKAANLVAVGDEIAAELGIPIVNKRVSVTPISLIGAATDATDYVVLAKALDKA
                     AKEIGVDFIGGFSALVQKGYQKGDEILINSIPRALAETDKVCSSVNIGSTKSGINMTA
                     VADMGRIIKETANLSDMGVAKLVVFANAVEDNPFMAGAFHGVGEADVIINVGVSGPGV
                     VKRALEKVRGQSFDVVAETVKKTAFKITRIGQLVGQMASERLGVEFGIVDLSLAPTPA
                     VGDSVARVLEEMGLETVGTHGTTAALALLNDQVKKGGVMACNQVGGLSGAFIPVSEDE
                     GMIAAVQNGSLNLEKLEAMTAICSVGLDMIAIPEDTPAETIAAMIADEAAIGVINMKT
                     TAVRIIPKGREGDMIEFGGLLGTAPVMKVNGASSVDFISRGGQIPAPIHSFKN"
     gene            59139..59831
                     /locus_tag="VXE25_000386"
     CDS             59139..59831
                     /locus_tag="VXE25_000386"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HEV0770913.1"
                     /translation="MVKVRLYLVRHGKTMFNTIGRAQGWSDTPLTAEGERGIQELGIG
                     LRESDLQFERAYSSDSGRTIQTMGIILEELGLQGKIPYRMDKRIREWCFGSFDGAYDG
                     DLFMGIIPRIFNVDHVHQLSYAELAEGLVEVDTAGWAEGWEKLSGRIKEGFEMIAKEM
                     EDQGGGNALVVSHGMTIGTIVYLINGMHPHGLDNGSVTILEYEDGQFRVEVVGDRSYR
                     ELGREKMEEGSI"
     gene            complement(59934..61586)
                     /locus_tag="VXE25_000387"
                     /pseudo
     CDS             complement(59934..61586)
                     /locus_tag="VXE25_000387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520796.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
     gene            complement(61576..61881)
                     /locus_tag="VXE25_000388"
                     /pseudo
     CDS             complement(61576..61881)
                     /locus_tag="VXE25_000388"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809465.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="TOBE domain-containing protein"
     gene            complement(62008..62667)
                     /locus_tag="VXE25_000389"
     CDS             complement(62008..62667)
                     /locus_tag="VXE25_000389"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862596.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0770914.1"
                     /translation="MSEIKIINAKKIYHDVPVIENLNITIPKGSLFTLLGPSGCGKTT
                     LLRMIAGFNSIEGGEFYFDDTKINNMEPSKRNIGMVFQNYAIFPHLTVRDNVAFGLMQ
                     KKVPKEELIQQTNKYLELMQIAQYADRKPDKLSGGQQQRVTLACALAVNPSVLLMNEP
                     LSNLEAKLRLDMRQAIREIQHEVGITTVYVTHDQEEAMAISDQIAVMKDGVIQQIGRP
                     K"
     gene            complement(62680..63801)
                     /locus_tag="VXE25_000390"
                     /pseudo
     CDS             complement(62680..63801)
                     /locus_tag="VXE25_000390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931989.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
BASE COUNT        19100 a        12025 c        14148 g        18632 t
ORIGIN      
        1 caatctgcta tataatagtc catgctgtgg ctggattctt ttcagcctac ttatactctt
       61 cgaaactctc ttcaaaccac gtcagcttca ccttgccgta tatgtgttac tgacttcgtc
      121 agttctatcc acaacctcaa aacggtgttt tgagcaacct gcggctagtt tcctagtttg
      181 ctctttgatt ttcattgagt attattaaaa caatatgagg agaaagatga aagaaaaagg
      241 attttaggag ggggcgcagg cagccatgcc aacggctctt ggctatgtca gtatcggcct
      301 ggcctgtggg actatcggtg ctccctatgt gacacctgtt gagatgggct tgatgagtct
      361 ctttgtttat gctgggagtg cccagtttgc catgttggca ctgattgtgg ttcaagctcc
      421 tgtggcagct attgctatga cggtttttct aatcaacttg cgtctctttt tgttgagttt
      481 acacgcatcg acttatttcc gtcataccag tctttggtac aatatcggta tgtctagtat
      541 cttgacagat gagacctatg gcgttttgat gggtgaattg gcccatacag acaaggtaaa
      601 tcctatgtgg atgcacggga acaatctcaa cagctatgtg gcttggtttg tggggacagt
      661 agtcggaacg gctctgggtg gcctgctacc aaatccagaa atctttggct tggattttgc
      721 cctggttggg atgtttattg gtatttttgc ttcgcaattt cagattatgc aaagacggat
      781 tcctgtccgc aatctgctca ttatcctagc agttgttgcg gtgtccttct ttttgctctt
      841 gacagtggtg tctcagtcac tagctgttct gtttgcgacg ctacttggtt gtagcatggg
      901 ggtggtttta gatggtcagt aagtatcttt tattagcagt tattttctct ggtcttgtga
      961 cctggattcc ccgtatgatt ctcttcatct tggtcaagca taagggcctg cctgcgattg
     1021 ttgagcgttt tttgaagttt ttgcctgttt ccattatctt tgccttgatt ctttcaagcg
     1081 tagtgacagg taaggttggg agccttcctc aaattaaatg gctagacttc ttagccgtct
     1141 ttccaacagc ttgggtagcc tttcgctacc gcaatctagt cggaacagtt ctctttggag
     1201 tggtcttgat tgccatcttg cgtttggtct tttaaattac ccataaaaaa aacttatcac
     1261 agagatagat atcatataat ggcgtaaatg ctctttttct gttaagatta taaggtattc
     1321 tattttggag gaaatgacat gaaaaaaatc gttaaatact catctcttgc agcccttgct
     1381 cttgttgctg caggtgtgct tgcggcttgc tcaggtggtg ctaagaaaga aggacaagca
     1441 gctagcaaga aagaaatcat cgttgcaacc aatggatcac caaggccatt tatctatgaa
     1501 gaaaatggcg aattgactgg ttacgagatt gaagtcgttc gcgctatctt taaagattct
     1561 gacaaatatg atgtcaagtt tgaaaagaca gaatggtcag gtgtctttgc tggtcttgac
     1621 gctgaccgtt acaatatggc tgtcaacaat cttagctaca ctaaagaacg tgcggagaaa
     1681 tacctctatg ccgcaccaat tgcccaaaat cctaatgtcc ttgtcgtgaa gaaagatgac
     1741 tctagtatca agtctctcga tgatatcggt ggaaaatcga cggaagtcgt tcaagccact
     1801 acatcagcta agcagttaga agcatacaac gctgaacaca cggacaaccc aactatcctt
     1861 aactatacta aggcagattt ccaacaaatc atggtacgtt tgagcgatgg acaatttgac
     1921 tataagattt ttgataaaat cggtgttgaa acagtgatca agaaccaagg tttggacaac
     1981 ttgaaagtta tcgaacttcc aagcgaccaa caaccgtacg tttacccact tcttgctcag
     2041 ggtcaagatg agttgaaatc gtttgtagac aaacgcatca aagaacttta taaagatgga
     2101 actcttgaaa aattgtctaa acaattcttc ggagacactt atctaccggc agaagctgat
     2161 attaaataat ttcttgaaat catccattct gagtaagatg ggtggtttct cagtttttag
     2221 ggatatagtt ttaaactata tatctgacta tctaataaca atttgtgaaa tcaaacaaat
     2281 tgtgagatac tagtacggta ttatttttaa ggagaaagaa tcatgaaaat caaaaaatgg
     2341 cttggtctag cagcccttgc tacagtcgca ggtttggctc ttgcagcttg cggaaactca
     2401 gaaaagaaag cagacaatgc aacaactatc aaaatcgcaa ctgttaaccg tagcggttct
     2461 gaagaaaaac gttgggacaa aatccaagaa ttggttaaaa aagacggaat taccttggaa
     2521 tttacagagt tcacagacta ctcacaacca aacaaagcaa ctgctgatgg cgaagtagat
     2581 ttgaacgctt tccaacacta taacttcttg aacaactgga acaaagaaaa cggaaaagac
     2641 cttgtagcga ttgcagatac ttacatctct ccaatccgcc tttactcagg tttgaatgga
     2701 agtgccaaca agtacactaa agtagaagac atcccagcaa acggagaaat cgctgtaccg
     2761 aatgacgcta caaacgaaag ccgtgcgctt tacttgcttc aatcagctgg cttgattaaa
     2821 ttggatgttt ctggaactgc tcttgcaaca gttgccaaca tcaaagaaaa tccaaagaac
     2881 ttgaaaatca ctgaattgga cgctagccaa acagctcgtt cattgtcatc agttgacgct
     2941 gccgttgtaa acaatacctt cgttacagaa gcaaaattgg actacaagaa agcacttttc
     3001 aaagaacaag ctgatgaaaa ctcaaaacaa tggtacaaca tcattgttgc gaaaaaagat
     3061 tgggaaacat cacctaaggc tgatgctatc aagaaagtaa tcgcagctta ccacacagat
     3121 gacgtgaaaa aagttatcga agaatcatca gacggtttgg atcaaccagt ttggtaataa
     3181 gaaacaggga ggtgggagag agaattccac ctcttgcttt tgtatagagc acggagtgta
     3241 aagaagacta ttcgttcata gaaaggtaga gagaatatgg tttttcctag cgaacaagaa
     3301 cagattgaaa aatttgaaaa ggatcatgta gcccagcatt attttgaggt tttgcgtacc
     3361 ttgatttcta agaaatcagt ctttgcccag caggttggac tcaaggaagt cgcaaattat
     3421 ctgggtgaga ttttcaagcg tgttggagct gaagtggaga ttgatgagag ctatacagcg
     3481 ccctttgtca tggcacattt caagagttcg cgtccagatg ccaagacctt gattttctat
     3541 aaccactatg acactgtgcc agcggatggg gatcaggtct ggacagagga tccttttacg
     3601 ctttcggtcc gcaatggctt catgtatggg cgtggagttg atgacgacaa gggtcatatc
     3661 acagctcgct tgagtgcttt gagaaaatat atgcagcacc atgatgattt acctgtcaat
     3721 atcagcttta tcatggaggg agcggaggaa tcggcttcaa cagacctaga taagtatttg
     3781 gaaaagcatg cagacaaact ccgtggggcg gatttgttgg tctgggaaca agggaccaaa
     3841 aatgccttgg aacagctgga aatttctggt ggcaataagg ggattgtgac ctttgatgcc
     3901 aaggtaaaaa gcgctgatgt ggatatccac tcgagttatg gtggtgttgt ggaatcagct
     3961 ccttggtatc tcctccaagc cttacagtct cttcgtgctg cggatggccg tatcttggtt
     4021 gaaggcttgt acgaagaagt acaagagccc aatgaacgag aaatggcctt gctagaaact
     4081 tatggtcaac gaaacccaga ggaagttagt cggatttatg gattggagtt gcctctctta
     4141 caggaggagc ggatggcctt tctaaaacgt ttctttttcg agccagcgct taatatcgaa
     4201 ggaatccagt ctggttatca aggtcagggt gtgaagacta ttttacctgc agaagccagt
     4261 gccaagctag aggttcgtct ggttccgggc ctagaaccgc atgatgttct ggaaaaaatt
     4321 cggaaacagc tagacaaaaa tggctttgat aaggtagaat tatactatac cttgggagag
     4381 atgagctatc gaagcgatat gagcgcacca gccattctca atgtgatcga gttggccaag
     4441 aaattctatc cacagggcgt ttcagtcttg ccgacgacag cggggacagg acctatgcat
     4501 acggtctttg atgccctaga ggtaccaatg gttgcattcg gtctaggaaa tgccaatagc
     4561 cgagaccacg gtggagatga aaatgtgcga atcgctgatt attacaccca tatcgaatta
     4621 gtagaggagc tgattagaag ctatgagtag agatattatc aagttagatc agatcgatgt
     4681 gacttttcac caaaagaaga gaaccatcac agcggttaag gatgtgacca ttcacatcca
     4741 agaaggggat atctacggaa tcgttggata ttctggagca gggaaatcaa cccttgtacg
     4801 ggtgattaat ctcttgcaaa aaccatctgc agggaaaatt accattgacg acgatgtgat
     4861 ttttgatggt aaggtcacct tgacggcaga gcagttgcgt cgtaaacgtc aagatatcgg
     4921 gatgattttc cagcatttta acctgatgag tcaaaagaca gcagaggaga atgtagcctt
     4981 tgcccttaaa cactctggac tcagcaagga agaaaagaag gctaaagtag ctaagttgtt
     5041 ggacttggtt ggtttggcag atcgtgctga aaactaccct tcacaattat ctggagggca
     5101 aaaacagcgt gtggcaattg cgcgtgcctt ggccaatgat ccaaaaatct tgatttcaga
     5161 cgagtcaact tctgcccttg accctaagac aaccaagcag attttggcct tgttgcaaga
     5221 tttgaaccaa aaattaggct tgactgttgt cttgattacg catgaaatgc agattgtcaa
     5281 agacattgcc aaccgtgttg cagttatgca ggatgggcat ttgattgaag agggtagtgt
     5341 gcttgaaatc ttctcaaacc ctaaacaacc tttgactcaa gactttatct caacagctac
     5401 aggtattgac gaagccatgg tcaaaatcga gaagcaagaa atcgtggaac acttgtctga
     5461 aaacagtctc ttggtgcaac tcaagtacgc tggagcttca acagacgagc cacttttgaa
     5521 tgaattgtac aagcattacc aagtaatggc taatattctc tatgggaata tcgaaattct
     5581 cgatggtact cctgttggag aattggtggt ggttttgtca ggtgaaaaag cagcgttggc
     5641 aggtgcccaa gaagccattc gtcaagcagg tgtacaacta aaagtattga agggagtaca
     5701 gtaagatgga atcattgatt caaacctatt taccaaatgt ctataaaatg ggttgggctg
     5761 gtcaggcagg ctggggaacg gctatctact taactcttta tatgacagtt ctttccttca
     5821 ttatcggagg cttcttgggg ctagtggcag gtctctttct cgtcttgaca gcgccaggtg
     5881 gtgtcttgga gaataaagtc gtattctgga ttttagacaa aattacctca atttttcgtg
     5941 cggttccctt tatcatcctc ttggcaatct tgtcaccact ttctcacttg attgttaaaa
     6001 caagtatcgg gccaaatgca gcccttgtcc cactttcttt tgcagtcttt gccttctttg
     6061 cccgtcaggt gcaggttgtc ttggctgaat tggatggcgg tgtcattgag gcggctcaag
     6121 cgagcggagc gactttctgg gacatcgtgg gtgtttacct atcagaaggt cttccagatt
     6181 tgatccgtgt gacgactgtg accttgattt cccttgttgg ggaaacagct atggccggtg
     6241 cggttggagc tggtggtatc ggtaacgtag ccatcgctta tggatttaac cgctacaatc
     6301 acgatgtgac catcttggca accatcatta tcattttgat tatctttgca atccaattct
     6361 tgggagattt cttgactaag aaattgagcc ataaataaaa aagagccgcg tggctctttt
     6421 taactgatca gattttctgt gcaaattttt tactcaaggc ttgtccaatc aaggcaccca
     6481 ctagggctcc gatgacaata cttgcgataa atagaaggac agttccaggg tttggagcga
     6541 ccatgatgcg gtcgatatat tcttgggatt ttcctcttgc cagaagagta gccatatagg
     6601 ctttgggcgc aatccacata agcaagattg gtcctgttgt actaaaggcg aaaataatga
     6661 aagaaaggaa gttctttgtt ttgtccttgt attttcctaa atgagctact tcatctgcta
     6721 ggaggccaca gataattcca ggaaggaagg aaccagcacc gtgtttagtt cccaagaaaa
     6781 agagggcaat gacaaggccg atagtggtaa tggctccaaa gcgcggaact tttgcgacta
     6841 ggatcatata gacgctaccg ccgacaaggg cagtaaaggc aggcgcataa aacatgtttc
     6901 cagtttggtc aaagagattg cccaaaagga caccaatccc catgcagagg aagtaaagaa
     6961 ctgcaaaaag cagtgtagtt aagatagatt tcttcatgaa ttgtctcctg ataatttttt
     7021 cacaattctc attgtaccac ggtttggtgg gattgtaaat ggatactaga agtttttgaa
     7081 aacgcttgaa atatgatata atggtttcat agttattttt aggggaatat catgggtaga
     7141 tttttagact ttgtctttaa tcgtttcttt ttagggatga ttgcgacagc cttcttttgg
     7201 ctattaactt tagtaggagg gattatcctt ggtctagcgc cagctagtgc caccttgatg
     7261 agcttatatg cagaacatgg ttatagcttt cgggaataca gtttgaagga ggcttggtct
     7321 ctttacaagc aaaattttgt ctcaagcaac ctgattttct atagcttttt aggtgtgggt
     7381 ctagttttga cctatggttt gtatctcttg gtgcaattgc ctcatcagac cattgttcat
     7441 ttgattgcga cccttttgaa tgtcctagta gttgccctga tctttttggc ttatacagta
     7501 tctttaaaat tacaagttta ttttgccttg tcctatcgaa atagtctcaa attatccttg
     7561 attggcatct ttatgagtct agcagctgtg gccaagattc tccttgggac tgtgctactt
     7621 gtagcaattg gttactatat gcctgccctg ctattttttg taggaattgg gatgtggcat
     7681 ttctttatca gtgatatgtt ggaacctgtc tatgaaatca tccatgaaaa attggcgaca
     7741 aaatagaatg aagcactttt ggctacatac gcttctaaga acctatagtt cagtgatgat
     7801 cattatcatt gcgagttttg caatcttact ctcttacgct gactgggatt cacgtgaaaa
     7861 ggaagcccag agagtagccc agcgtgtaac tgctagaaca gtgagtgaaa ttgaatatta
     7921 ccatagagag tcaacccaga tagctcaggc tttagttgaa aaccaagctc gtattgaggg
     7981 aatctataaa tactttagcc ttagcatgcc agactatttt tactggcaat tagagcggaa
     8041 agcttcgcct tatatatcag tctctctgta tgaaaatgtt gatgacctct atgttcgaaa
     8101 tgattttgta actggggtgg ccattgcttt tcaagattac aaggaagtct atgtttctac
     8161 taaagacaaa cgtagtggag aaaaaatcag ggctgaggat ttcaaaccag caggaaatag
     8221 ttttgccatt ccggtgtcag atccagtgtc agatcaagat ttaggagtga tttacatctc
     8281 cttggatcct gctgttttat accatgccat tgataatact agaggtcata ctccgatggc
     8341 agtaacagtg acctcacctt ttgatacgga gatttttcat attggtgaga cagttgatag
     8401 ggagagtgaa aattggctag ttggcttaac ttctcatgga tatcaggttc aggtggcagt
     8461 tcctaaaaac tttgttttac aaggaacagt gactagctct gctttgattg tgggtttgag
     8521 ccttctcttt attgtcattc tttatctgac tttgaggcag acttttgcta attaccaaaa
     8581 gcaggtagtg gatttagtag aatccattca agtcattgct caaggcgaag aggggcgtcg
     8641 gattgacatt tccgagaaag atcaggaatt actcctaatc gcggagacga ccaatgatat
     8701 gttggatcga ttggaaaaga atatccatga tatttaccag ttagagctta gtcaaaaaga
     8761 tgccaatatg cgagccttgc aggcgcaaat caatcctcat tttatgtata atacgctgga
     8821 gttcttgcgc atgtatgcag ttatgcagag tcaagatgag ttggcagata tcatttatga
     8881 attcagtagt ctcttgcgta acaatatttc cgacgaaaga gagaccctcc tcaaacagga
     8941 attagaattt tgccgtaaat acagctatct ctgcatggtt cgctatccca agtccattgc
     9001 ctatggtttc aagatagatc cagagttaga gaatatgaag attcccaagt ttaccttgca
     9061 accgctggta gaaaactatt tcgcgcatgg tgttgaccac aggcggacag ataatgtgat
     9121 tagcatcaag gctcttaaac aggatggttt tgtggaaatt ttggtggtcg ataatggtag
     9181 aggaatgtcg gctgaaaagt tggcaaatat ccgagaaaaa ttaagtcaga gatattttga
     9241 acaccaagcc agctacagtg atcaaaggca gtctatcggg attgtcaatg tacacgagcg
     9301 ttttgtgctc tattttggag accgctatgc cattactata gagtctgcag agcaagccgg
     9361 tgttcagtat cgtattacaa ttcaagatga gtagaaaggg agaaaatgta taaagtatta
     9421 ttagtagatg atgagtacat ggtgacagaa ggtctgaagc gtttgattcc ctttgataag
     9481 tgggatatgg aggttgtcgc aacagccagt catgccgatg aagctctaga atatgttcag
     9541 gaaaatcctg tcgatgtcat catttccgat gtcaatatgc cagacaaaac agggcttgat
     9601 atgattcggg agatgaaaga gatcttacca gatgctgcct atatcctgct ctcaggttat
     9661 caggagtttg attatgtaaa aagagcaatg aaccttagtg tggtggacta tttggtcaag
     9721 cctgttgata aggtagagct gggaaatctg ctggagaaga ttgcaggtca gctcggcgag
     9781 agagggaaga aaagtcagac tcttagtcaa gaattagacg aggctggatt tgttagttat
     9841 ttaggggata aggagaattg gtggataggt ctatccaagg aaaaacaagg ttccttcacc
     9901 attccctact atgtcttggg ccaagactgg cagattttca tttctggcca acctctagat
     9961 ggtttagtcg ttacaccttt tgaagctcct tatcaagaac actttgaacg ctggaagctg
    10021 aatgctgaga aaaccctctt ttacggttct gtaaatttgc agcagtctga gagtctcttt
    10081 gcctattacg aaccgattta tagggttatc attcagggaa atctcaatca aatcgtagaa
    10141 gagttaaatc tcttggagaa ggtagttctt gaaaatacgc cgcgtgttcc gattactaaa
    10201 cagcttttta ttcagtttgt catggatgtt ttccatttat ttgaacatct caaagctgat
    10261 gacctgacag acatcgtcaa aaccattcat gctattcaat ccttcgatga attggtttct
    10321 tatatcaagg aaactctgat cagctttttc ggtcaatacc gtatgaatga aaatgtggtc
    10381 agtgtgctgg aagtcattgg tcgtgattac caaaaagagc tttccctcaa ggatatcagt
    10441 aaggctctct ttatcaatcc tgtctatcta gggcagttga ttaagcgtga aaccgattcg
    10501 acctttgcag agttactaaa caaacaacgt attaaggctg cccaacaact tttgctttca
    10561 actagtgaca gcatcgaaga tatttgttat gctgttggtt acagtaacct tggatatttc
    10621 tataaagttt tccgaaaatt gtgcggaaaa tcgccaaaag cctaccgaaa acaggtagaa
    10681 actatactat aaaatttgta ttcctttaca aaaggtgcta taatattatc aggaggttct
    10741 atcatgaaaa agaaaccaat ttatctatgg gtcttgctaa tcttgtctgc ccttatttca
    10801 gttccgtctc tgtttggaat tgtgagtccc ttgcctagta aggaagccct tcgtgctgct
    10861 cagaaacaag ttgcaggggt caatgctcag caattagaag accagcttaa ttatacctat
    10921 agagtagcag aagcatctca ttctattttt aatgttgctt tgattgtgct atctactatt
    10981 ttagtggtcg tagcgattgt cttccttgtt cgtaaaaatt tgcaatatgc aaactatact
    11041 tacgttggct atgttttgtt agctattatt ggttcgattt atggctatgt tggtttacaa
    11101 gacgctgtgc agttggttca agatgagagc atgcgtttga cagtgagtat tggttcaaaa
    11161 gctgttagca ttttctatat cgtcatcaat gttctcttcc tagcccttgt cttctataag
    11221 atgtggcgac aacagaaagc cttggcagaa gaagaggaaa cagaagagct tgcctaagta
    11281 ttgacaaaaa agaactatca agatacaatc ttggtagttg ttttttgatt atagataaaa
    11341 tcatggaggt acatatgaag acaatttctt tagtttatat tagtttgagt ggcaacactg
    11401 aaagttttgt gacgcgcttg aaagactatc tcttgtccca gtacaaaggg attgaggttc
    11461 aaaagattca tatcaaggat ttagtcaagg aaggcaaaaa tttctatgaa atggaccatc
    11521 cctatgtcgc ttttttgccg acctatctcg aaggtgggaa tggcgtggat aacggagatg
    11581 ttgagatttt gacgacaccg gtgggagatt ttattgccta tggtaacaat gctagtaagt
    11641 gttttggtgt ggttgggtca ggaaatcgta actttaataa ccaatactgc ctaacagcca
    11701 agcaatacag tcaacgcttt ggctttcctg tattggctga ctttgaaatg cgaggcatgc
    11761 tggaagatat caaacatgtc gcagctatta tcgcagattt gtatgagttg gaaaaggaga
    11821 attaatactc aatgaaaatc aaagagcaaa ctaggaagct agtcgcaggt tgctcaaagc
    11881 acagctttga ggttgcagat agagctgacg tggtttgaag agattctcga atagtataaa
    11941 gttcttataa gaggtggttg aagttgttca actgtttttt gagtataaac agtctttaag
    12001 aacgtaaaaa agcataagtt caggtcttca aaaccttgtt cttatgcttt ttatcataga
    12061 aatatttgct gaattttctc ttgaaatgaa accttatctt catctcgcgc ttgtccctta
    12121 ccctgctttt ccgattgcga gtgcgtagat aaagaagatg gcgaagccaa agaggaaaat
    12181 caatcccgca atggcaaggt gtttgagcca agaaggaaga tttttgtttt cacgcgttac
    12241 caaggcgtaa ttcaaaagag caaagaaagg tgttgtcagg aaagagccaa tcatggcaaa
    12301 gcggagcatg gttgaaacct gaccagcgaa gaacttgata atgacgatac cgatgatagc
    12361 agtgatggtc atccagatgt tcaaagattt acgattgtcc tctttttgac tgattagcag
    12421 tcggagagat tcctgattaa cgcgagaata gccatcgata acagttataa ctgttccaaa
    12481 gatacagagg aaggcaataa aggtaatcaa gtaacgggac cattcgccaa gaacagaggc
    12541 atacatgccc acgaattgag agatgtattt ggctgaagca gcttcaaccg cctgccctgt
    12601 aggatactga atcagtgctc ccagtgccac aaagaagacg gctaggatag ctgttccaat
    12661 ataaccagtg ttaaagtcaa acacagcgtc ttctgtgtta aagttgacgg tctttctctt
    12721 ttcagctgac caaagtgaat tgatggctga aatttcaata ggagccggca tccatcctag
    12781 gagggagacg atgaagggca gagctgccat ttgccaaggt gtcttctcga caaaatcaga
    12841 actgtattct ggatgcttga ccgccgcaat gataactgca agaacagtcg caatggttaa
    12901 ggcagacata atccatttga ccatgccgtc taaaagtttg tagcctccaa agagtagcat
    12961 agcccaaatg attgcaacga gaatgaggga ccactgagta atgctaagtc caatcattgg
    13021 gaaggcactg gcgatgatag ctgagcacag aatggcaaca ccagccgtgt tgaccatagc
    13081 cgaaaagaca ttgaggataa agaaaatcca gagatagagt tttccttttt cggcataacc
    13141 ttcaaccaaa gtctttccag tatcagctgt gtattcagca ccaaaacgga aaaatggata
    13201 tttaaagaca ttggctaaga tgaccaagag aagtagagac caaccgtaag aaccgccagc
    13261 ttgagttgag gatacaatgt gggaacctcc aacagcggca gttgccatta ggattccagg
    13321 tcccattgct tttagcttgc ttgcccaggt tgattgattt aaggaaatag cttgcgacat
    13381 gataaatact cctttttgaa ttttcagaat aatctgtata tgtaatctat attctacaaa
    13441 aaattttgga aaaatgcaag agtattttga aaaaagatag aaaatttaca aagaaaatct
    13501 gaaataactg ttatgatata gcagattgaa actagaatag tacacttttg cttctaaaac
    13561 attgttagaa atcgatttga ctgtcctgat tgatttaccc tgttcttatt tcatttcact
    13621 atagtaaggt gcagcaggat aaagcaaaac cgagaagttt ctttctcggt tttgcttatt
    13681 atgaggttcc tattttctat gctccaagag ttgattgatg tgatctactt ttttagcctc
    13741 tcttttatag agaatagccc agatgatgag atagacaatc gcaaactcga taatgagctg
    13801 gaggtagaaa atccagtgga aggggaacca accagcaaga gttgctagtg ggacaaagcc
    13861 agccagcata aggaagaaat gagtcagagt ggcacgaagc atgctccagt cacggctgaa
    13921 taagcggttg ccaaagttga agagcatacc gatggctgcc cagataagtg tgcagtagag
    13981 caagaccagg gcaccgtgaa cctgatgctg atccatcact tggccgatga gagagtaggg
    14041 atttagtggt gcgtaggtat ttggtgcata aatgagtgaa aagaggatgg agaggatgag
    14101 gccgataaga acaccggcag ctgcatcgtg aaatacttgt tttttcatag ttctaatttc
    14161 tccttgatgg tttttagata acggcgtgaa gagtaggtga agctttcgtt tttcaagaaa
    14221 atttctacca gaccgtttgg cgtgagcttg aggtgagaga tggaatcgat attgatgatt
    14281 tctgattggg aaatttggat aaaattggtt ggcaagagtt taagaacctg atagagtcgc
    14341 aaatcaatgc tgtaggtctg actcgcggtt tctgctagaa ccttccgatt ctcgatatag
    14401 aagcgctgaa tcttgccaat ctcaactaga tagacctgat catcgatttt tcctttgatt
    14461 ttttctcttt ggtccagatt ttctgcgaac tcgatgactt tctggacttt ttcggtttct
    14521 tgaggtgctt ggacaatcag cttttcctcc tcgtaagtct cactaatctg tagttctact
    14581 ttcataaatt tctctccttg tttttcatac aaaattaatc tcacttcttg tacaccttta
    14641 ttaatactct tcaaaaatct cttcaaacca cgtcagcgtc gtcttgccgt aggatagttg
    14701 ttgactttgt cagttttatc tacaacctca aaacagtgtt ttgagctgtc tgcgtctagc
    14761 tttctagttt gctctttgat ttttattgag tataccacta ttttactccc tctggcaagg
    14821 gactttgtct atgtggaggg attgggctcc tatgtggtgg agtttttctg ttctttctga
    14881 aatatggtat aatagcacta attaatttct aggaaaatag atacagaaag gggctgaaag
    14941 atgtctcata ttattgaatt gccagagatg ctggcaaacc aaatcgcagc tggggaggtc
    15001 attgaacgtc ctgccagtgt ggttaaagag ttggtagaaa atgccattga cgcgggctct
    15061 agtcagatta tcattgagat tgaggaagct ggtctcaaga aggttcaaat cacggataac
    15121 ggtcatggaa ttgcccacga tgaggtggag ttggccctgc gtcgccatgc gaccagtaag
    15181 ataaaaaatc aagcagatct ctttcggatt cggacgcttg gttttcgtgg tgaagccttg
    15241 ccttctattg cgtctgttag tgtcttgact ctgttaacgg cggtggatgg tgctagtcat
    15301 ggaaccaagt tagtcgcgcg tgggggtgaa gttgaggaag tcatcccagc gactagtcct
    15361 gtgggaacca aggtttgtgt ggaggatctc tttttcaaca cgcctgcccg tctcaagtat
    15421 atgaagagcc agcaagcgga gttgtctcat atcattgata ttgtcaaccg tctgggcttg
    15481 gcccatcctg agatttcttt tagcttgatt agtgatggca aggaaatgac gcggacagca
    15541 gggactggtc aattgcgcca agcaatcgca gggatttacg gtttggtcag tgccaagaag
    15601 atgattgaaa ttgagaactc tgacctagat ttcgaaattt caggttttgt gtctttacct
    15661 gagttgactc gggctaaccg caattatatc agcctcttca tcaatggccg ttatatcaag
    15721 aacttcctgc tcaatcgtgc tattttggat ggtttcggaa gcaagcttat ggttggacgt
    15781 tttccactgg ctgtcattca catccatatc gacccttatc tagcggatgt caatgtgcat
    15841 ccaactaagc aagaggtgcg gatttccaag gaaaaagaac tgatgaccct ggtttcagaa
    15901 gctattgcaa atagtctcaa ggaacaaacc ttgattccag atgccttgga aaatcttgcc
    15961 aaatcgaccg tgcgcaatcg tgagaaggtg gagcaaacta ttctcccact caaagaaaat
    16021 acgctctact atgagaaaac tgagccgtca agacctagtc aaactgaagt agctgattat
    16081 caggtagaat tgactgatga agggcaggat ttgaccctgt ttgccaagga aaccttggac
    16141 cgattgacca agccagcaaa actgcatttt gcagagagaa agcctgctaa ctacgaccag
    16201 ctagaccatc cagagttaga tcttgctagc atcgataagg cttatgacaa actggagcga
    16261 gaagaagcat ccagcttccc agagttggag tttttcggac aaatgcacgg gacttatctc
    16321 tttgcccaag ggcgagatgg actttacatc atagatcagc acgctgctca ggaacgggtc
    16381 aagtacgagg agtaccgtga aagcattggc aatgttgacc agagccagca gcaactccta
    16441 gtgccctata tctttgaatt tcctgcggat gatgccctgc gtctcaagga aagaatgcct
    16501 ctcttagagg aagtgggcgt ctttctagca gagtacggag aaaatcaatt tattctacgt
    16561 gaacatccta tttggatggc agaagaagag attgaatcag gcatctatga gatgtgcgac
    16621 atgctccttt tgaccaagga agtttctatc aagaaatacc gagcagagct ggctatcatg
    16681 atgtcttgca agcgatctat caaggccaat catcgtattg atgatcattc agctagacaa
    16741 ctcctctatc agctttctca atgtgacaat ccctataact gtcctcacgg acgtcctgtt
    16801 ttggtgcatt ttaccaagtc ggatatggaa aagatgttcc gacgtattca ggaaaatcac
    16861 accagtctcc gtgagttggg gaaatattaa aagtataaaa aagtctggga aaaattttca
    16921 aaatcagaaa aacgcataaa atcaggtgtt caaaaacctt gattttatgc gttttatcat
    16981 agaaatattt acttcatgtt ttcctaattc ttttcgaaac tctttttaaa ccacgtcagt
    17041 tttatcagta atctcaaaac agtgttttga gctaattttg ccagttttgt ctgtaacatc
    17101 gaagttgtgt ttgaccactc tgcgactggt ttcctagttt gctctatgat tttcacagag
    17161 tattaaattg cgattttgcc aagtttcttt attcgtctaa aagtagagtc tgttctatgc
    17221 gtctaatgta cgaattaggt tgaccatttc aatagctcct tgtgcacact cagaaccctt
    17281 atttcctgct ttagtgccag ctcgttctat ggcttgttca attgtatctg tcgttagcac
    17341 accaaacata acaggaattt cgctatttaa actgatttgg gcgattccct tagatacctc
    17401 gctacataca taatcataat gacttgtatt ccctctaatg acagctccca agcagataat
    17461 tgcatcatat tttttacttt ttgccatttt tgatgcaatc agtggtattt caaaagctcc
    17521 tggaacccag gctacctcta tatctttctc gtttacattc tctcttttga gattatctag
    17581 tgctccagat aataattttg aagttataaa ttcattaaat ctcgctacaa caatacctat
    17641 tttaatattg tttgctacta aattaccttc ataagtgttc atttattttt cctccatatt
    17701 taaaatgtga cccattcgat ttttctttgt ttctaaataa aaactatcgt aaggattggc
    17761 ttctatttcg attgatattc tactggaaat ggtaattcca tatttttcta actgttcaac
    17821 cttgtcagga ttatttgtca gtaaatgaag tgactgaagt cccagatctt taagcatttg
    17881 tgctccaata tgatattctc ttaaatcacc ttcaaagcct aatgcaagat tggcatcaag
    17941 cgtatccatg ccttgatctt gtaaatgata ggcttttaat ttattgataa gtccaattcc
    18001 tcgtccctcc tgtcgcaagt aaagtaagac acccgaacca ttctcaacaa tcattttcat
    18061 agctttatcg aattgctgtc cacaatcgca acgtaaggag cctaaaacat cccctgttaa
    18121 acattcggag tggacccgac ataatacatt ggcttcatcc tctatgtttc ccataataag
    18181 agcaagatga tgttccccat ttagtttatc tatatagcta attgctttga aattaccgta
    18241 tctagtaggc atattgacag ttgaaactcg ttctaccagc tgatcatata cttttctata
    18301 ttcttgtaat tctttgatgg taattagtgg aatgttgtgt ttcttcgaga actgaattaa
    18361 atcatctgtt ctcatcattt tgccatcatg attcattatt tcacaacata ggccacactc
    18421 ttttagtcca gctaatttta ataaatcaac agttgcttct gtgtgtccac ttctttctag
    18481 aacaccacct ttttttgcaa ttaaaggaaa catgtgtcct ggcctgcgaa aatcagaggg
    18541 tgttatatct tcagctacac acatacgtgc ggtcagtcct ctttcctcgg cagaaatacc
    18601 tgtggtcgtt tctttataat caattgaaac tgtaaaagca gtcttatgat tatctgtatt
    18661 gttttcaacc ataggtgaaa gcattaattg attagctaaa ctttcgctca taggcataca
    18721 aattaatcct ttggcataag tagccataaa attaacattt tctgttgtag ctgcttgtgc
    18781 agaacaaatt aagtctcctt cattttctct atccttgtcg tctataacaa gaacaagtcg
    18841 tcccttctgc aatgcttcta atgcttcttg tatttttcga tattccattg actgattatc
    18901 ctttctgcta aaatccattt tgatataata gttccttaga tatttctgat tttggagagt
    18961 tatccatcag tttttgcaca tatttaccta agatatcatt ttcaagattt actgtactcc
    19021 cgacttgttt actcttaaga atggtttgtt ccaaggtatg agggataaca gatactgaaa
    19081 agtttacttt ggagacttta gcgacagtca gactaatgcc gtcaattgta atagatcctt
    19141 tttcaactat taaatctaaa atttcttttt gtgtgttgat ttgataccat acagcattat
    19201 catctttttt tattgacgag atttttcctg taccatcaat gtgtcctgta acgacgtgac
    19261 ccccaagtcg accgttgaca gataaggctc tttctagatt cacctcactt ccatgtttta
    19321 atagagtaag agctgttcga ctccatgttt cattcattac atcaactgta aaggattgat
    19381 gattgaaatg agtaactgta agacagatac catttactgc tatactatcg cctaaatgga
    19441 tatccgttaa tatttttgag gctttaattg atagtttaca attacgagag tctttctgta
    19501 ttctttcaac ttttccgatt tcttcaatta ttcctgtgaa catggataaa tcacttcact
    19561 ttctatgaga tagtcatttc ctatttgaga aaatgcataa ggtttcaatc taatagcgtc
    19621 atttggcaaa gaaatacctt cacctccgac aggaaacttg gcactacctc caaaaatttt
    19681 tggtgcaata tatattttca gctcatcaac aatttgttgt tccaaagcac tccaattcat
    19741 tagactgccc ccttctagaa ctaggctatc aatctgcatg tttcctagat gttgcattaa
    19801 actcgataag tctatatgat tgcctttttt ctttatggaa agtatttcac agccatgatt
    19861 ttgatatagc ttcattttat ttttgtcttc agaggaagtg gcaatgtaag ttttaatatc
    19921 atttgctgtt tttacgattt tagaggtaag aggagttcgt aaatgtgtat cgcatatgat
    19981 acggatagga tttttccctt cctccaatct acatgtcagc aaaggatcgt cttgaataac
    20041 agtattgact cccaccataa ttgcactaac atggtgtcgt aactgctgca catgctttct
    20101 tgcttcttct tcagtaatcc atttggattg atttgtttta gtggctattt ttccatccat
    20161 tgacattgca tatttcataa aaacataggg tacatgctgg gtaatatact ttctaaaact
    20221 ttttattaag ttaagacact cattttctaa aattccaaca gtaacttgaa gattattttc
    20281 ctcaagtatc tttactcctt ttccagatac aataggatta cagtctaggc ttccaatgac
    20341 tactcttgta ataccactat cgattatagc atctatacag ggaggtgttt tcccgaagtg
    20401 acaacagggt tcaagtgtta cataaagcgt cgctccgaca ggggattctc tacagttttt
    20461 aagagcattt ctctcagcat gtgggccacc aaaaaactca tgataacctt gtccgataat
    20521 gtgattatct tttacaataa ctgcgccgac cataggattg ggattgacgt aaccagcccc
    20581 tttttgtgcc agttttattg ctaatttcat atattttgaa tcgctcatct cactacctcc
    20641 aaaaaaatat gccttgaata ggggactact caaggcatac aaaagaaaac ttatgcgatt
    20701 aacaaaaatg ctctgaaatg acaagtaatc atttcagagc acgcaaaaag cacaaatata
    20761 cttttatctt ctttcatcca gactatactg tcggctttgg aatttcacca aatcatgcct
    20821 ttcggctcgt gggctatacc accggtaggg aattgcaccc tgccctgaag atagttattc
    20881 aattacagat gattatagta cttaattttg aatatgtcaa cagataaata ccgattgttt
    20941 ttgatatact gtatttgtga taatcgattc tcgctcctcg gataaagaaa atatgatata
    21001 ctagataaac gaaataagag agaaggaata ctatgtacgc atatttaaaa ggaatcatta
    21061 ccaaaattac tgccaaatac attgttcttg aaaccaatgg tattggttat atcctgcatg
    21121 tggccaatcc ttatgcctat tcaggtcagg ttaatcagga ggctcagatt tatgtgcatc
    21181 aggttgtgcg tgaggacgcc catttgcttt atggatttcg ctcagaggat gagaaaaagc
    21241 tctttcttag tctgatttcg gtctctggga ttggtcctgt atcagctctt gctattatcg
    21301 ctgctgatga caatgctggc ttggttcaag ccattgaaac caagaacatc acctacttga
    21361 ccaagttccc taaaattggc aagaaaacag cccagcagat ggtgctggac ttggaaggca
    21421 aggtagtagt tgcaggagat gaccttcctg ccaaggtcgc agtgcaagca agtgctgaaa
    21481 accaagaatt ggaagaagct atggaagcca tgttggctct gggctacaag gcaacagagc
    21541 tcaagaaaat caagaaattc tttgaaggaa cgacagatac agctgagaac tatatcaagt
    21601 cggcccttaa aatgttggtc aaataggagc agagaatgac aaaacgttgt tcgtgggtca
    21661 agatgaccaa cccgctctac atcgcctatc atgatgagga gtggggccag cccctccatg
    21721 atgaccaagt attgtttgag ttgttgtgta tggaaaccta tcaggcaggc ctgtcttggg
    21781 aaacggtact caacaaacgc caagctttcc gagaagtctt tcatagctat caaattcact
    21841 cagtcgcaga gatgactgac actgaattgg aagccatgct ggagaatcca gctatcattc
    21901 gaaatagagc caagcttttt gctacacgcg ctaacgccca agtctttcta cagttacagg
    21961 cagagtacgg ctcttttgat gcctatcttt ggtcttttgt tgaggggaaa actgtcgtta
    22021 acgatgttcc tgattatcgc caagcgccag ctaaaacacc cttatctgag aaattagcca
    22081 aagatctcaa aaaacgaggc ttcaagttca caggcccagt cgccgtattg tcttttctac
    22141 aggctgcagg gctagttgat gaccacgaga atgattgtga gtggaaaggt cttaaatgat
    22201 gtctaacaaa aataagggaa ttctgatttt tgcgattctc tatacagtcc tctttgtgtt
    22261 tgatggcgtt aaattgctgg cttctttaat gccatctgtc attgcaaatt atcttgttta
    22321 tgtagtttta gctttatatg gctccttctt gttcaaggat agattgatcc aacaatggaa
    22381 ggagattaga aagactaaaa gaaaattctt ctttggcgtc ttaacaggat ggctctttct
    22441 cattctgatg actgttgtct ttgaatttgt atcagagatg ttgaagcagt ttgtgagact
    22501 agatggacaa ggtctaaatc agtctaatat tcaaagtacc tttcaagaac aaccactact
    22561 gatagctgtt tttgcttgtg tcattggacc tctggtagaa gaattatttt tccgtcaggt
    22621 cttattgcat tacttgcagg aacggttgcc aggtttacta agcattattc tggtaggact
    22681 tgtttttgct ttgactcata tgcacagttt ggctctatca gagtggattg gtgcagttgg
    22741 ttacttaggt ggaggccttg ccttttctat tatttatgtg aaagaaaaag agaatatcta
    22801 ctatccccta cttgttcaca tgttaagcaa cagcctctcc ttaatcattt tagctatcag
    22861 tatagtaaaa tgaaataaga acaggacaaa tcaatcagga cagtcaaatc gatttctaac
    22921 aatgttttag aagtagaggt gtactattct agtttcaata cactgtaaca tgtgatgaaa
    22981 atgccagtaa tgataccgag aaaaaagctg agaaactttt cccagcttta tttgttatag
    23041 tcaaagcgaa tgacttgttc ctgtgcatct acatgagcat ggaccccaaa gggtacaatt
    23101 gctcttggag ttgcgtggcc gacattcaga ttatagacaa tcgggatatt gctgtcaatg
    23161 atatctaata gtgcctcttt atagtcgtca tggaaagttt catccatagg ttttccgacc
    23221 aagagtccat tgatgaccgc gaatatgcca gtgtccttta aagttagcaa catctttttg
    23281 aagtcttctg gcttaggctt ttcttcgctt gtttcgagca agaggatttt cccttcccag
    23341 tctgacaagt cagggaaaag tttgtatttt gggcagagtt ccgtgctatc tgcgtatcga
    23401 gagttgtcaa agatatcgta gagggattcg aggcaaccac cgaggatttt cccctcgaac
    23461 tgagcacttc cttgcaacaa gtcaaaacct gtatttgtat gactgacacg aggtgttccc
    23521 agggccgtgg gactaaaatc agttcgttcc tcataccaaa cgtcactagg gcggatttct
    23581 gaaattcttc ccgtctcaat caattcttta aagtagtgaa ggctataggc tagcatttct
    23641 ttgtctaatt cacaaatgtc tgctaaaaag gattgaccat aaaaagtctt gattcctaat
    23701 ttatgcaaca tgaggtggtt catggttgta tccgagaagc caagaaaaat tttttgcttg
    23761 ataacctttt ggagttggtc attttcaaaa agataaggta gcaagcgata ggtatcgtct
    23821 ccaccgatgg cacataggat catgtcgatg ctatcatcag aaaaggcatg aatcaaatcc
    23881 tctgcacgag cttcaggatg gtccttgata aagtctaatc cttttaacga atggggcaaa
    23941 aagatgggat tgagtcccag atccttgaga cgttggatac ccaagtccac ttcgtgtttg
    24001 acaaaatcct ctccgataat gccactagat aaactaacaa taccaatagt agaaaccata
    24061 tctcatcctc ctagaaatag attgagccta ttttatcaca aaatataaga gaaagctatg
    24121 tgggatttca gaagaatact tttaatactc ttcgaaaatc tcttcaaacc acgtcagttt
    24181 tatctgcaac ctcaaagctg tgctttgagc aacctgcagc tagcttccta gtttgctctt
    24241 tgattttcat tgaatataac tcaaaaaagt aagtgaaaaa gcaaccgcac ctgcagttgc
    24301 ttttatcgtt ttcttattct tgatagcgtg ttggtcctgc acttgcacta cggatattca
    24361 agcgtttctt gagatagaag cgaagggcta ggagggctgc tccaataata gctagtggca
    24421 atggatccag tactgggtta aggctagctg gtaggaagct tgttgcaaag aagacaagca
    24481 accaaaggaa catagaagct aggataacta gtacagattt ccagaaaggt ggacgttgac
    24541 tgcgatccat atctggtcca tagtattggt aaacaaagta gtacatcaag tagaaggcaa
    24601 atccaccaac cagtccaact aatagaagag taatcaatcc atagccgaaa gcttgatctg
    24661 ccgcaaagaa ggttgtgagg gcgctgacaa gggcaaagag gctagtgatg aaaagagctg
    24721 agtccataat catcagtttt ggatcatcat tttcttttgg atgctctttt tcgtactgct
    24781 ctttgacagt gaagctatga gcccaatgag ttggtgcgcc gtatagggaa cgggcagttg
    24841 tacctttaga ttgctcctca aggatttggg gaatgacttc ctcaaaaata gtctggattt
    24901 cagcgtctgt tttcccatct ttgatgaatt gttgggtagc aatgtggaca aactcttggt
    24961 ttttcttagt taatttttgt agatcaattt gagacatagg aactcctctt agaaccattt
    25021 tttatggatg agatagagag tgagcgagac actcatagca aaggcgataa agacgattaa
    25081 ccagaaggca tttggctctc cgtttagggg gatttcatta tccttaaagt tcatcccgta
    25141 ggcagaaaag accatggttg ggatggacat gacgatggtc acaagggcca aggttttcat
    25201 gatgttgttc tggttgttag aaatgataga ggcaaaggtc tctgtcatag aatgcaagac
    25261 gtttccataa atatctgcca tctcgatggc ctgttgggtt tcaatcaggg tgtcttcaag
    25321 caggtcttcg tcctcaaggt atttcttgat attgctggtt gaactggtca atttcttaat
    25381 cacgcgctca tttgttttga gggaggcctt gaaatagacg atagtttttt ccaattccat
    25441 gagctcaatc aattcttcat tacgagttga ttgatgcagt tgactttcga tttgttcact
    25501 cttgcggtcg attgaacgaa gggctgttag gtaaagctct gcattgcgat aaagaatttg
    25561 aaagataaaa cgtgaacgca tgaaggtata gaaattacgc aatcgacggt tgataaagac
    25621 atcaaggaca ggtagtggtt ccaaacacgt agtgataatg gtttcctcag tgatgataat
    25681 accaagcggg atggttacgt agtaggtgcg gttatttctt tcctccgtga ccggcacgtc
    25741 tacgataatc agggtatact cgtcttcaat ggtaatacga gacatttctt ccgcatcgag
    25801 cggtgctcga aggtcggcaa tatcaatatc gaaggtgttg gcgatttcga gtgattcatt
    25861 ttgagtcgga ttgacgagat tgatccaagt acccggttca agcgtatcga tctctttaaa
    25921 ttcagttgtt gtagagagaa aaacttgttt catatccctt atcctttctc atttttcaga
    25981 ttttttcaca ctgtactatt atactacaaa atcggccttt tgggtaatag aatctcactt
    26041 tttttggtat aatggtaagc aataatggac tagaaagaac aaagatgcaa gataaaattg
    26101 tcattcatgg ggcgcgtgcc cataatttaa aaaatattga tgtggagatt ccgcgagaca
    26161 agctggttgt cgtgacaggt ttgtcaggtt cagggaaatc cagtctggcc tttgataccc
    26221 tctatgcgga gggacaacgt cgctatgtag agagtttgtc agcctatgct cgtcaattct
    26281 taggaaatat ggagaaggcg gatgtggatg ccattgatgg tctcagtcca gctatttcta
    26341 tcgaccagaa aacgactagc aaaaaccctc gctcgacggt gggaacaacg actgaaatca
    26401 atgactatct gcgtctcctc tacgcacgtg tggggacgcc ttactgtatc aacggacatg
    26461 gagctatcaa tgcttcttct gtggagcaaa tcgttgataa ggttttggag ttacctgaac
    26521 gccagcgctt gcagatcttg gcccctgtca tccgcaagaa aaaaggccaa cataagagtg
    26581 ttatcgagaa ggttcagaaa gacgggtatg ttcgtgtccg tgtggatggg gaagtctatg
    26641 atgtgaccga agtgccagag ttgtctaaga gcaagcaaca caatatcgat gtcgtggttg
    26701 accgtattgt tatcaaggag ggcattcgta gtcgtctctt tgattccatt gaggctgccc
    26761 ttcgtattgc agaaggttat gtcattatcg acaccatgga cgactctgag ttgttgttct
    26821 ctgagcatta tgcctgtcca gtttgtggtt ttactgtccc agagttagag cctcgtctct
    26881 tctctttcaa tgctcctttt ggctcttgta gtgagtgtga cggcttgggc atcaagctgg
    26941 aggtggatac tgatttggta gtgccagatg ccagcaaaac cttacgtgag ggagcgttag
    27001 caccttggaa tcctatctca tccaactact atccaaacat gttagagcag gccatgaaag
    27061 tctttggagt ggctatggat aagccttttg aggacctgtc agaagaagat aagaacttga
    27121 ttctctatgg gtcagatggt aaggaattcc atttccacta tgagaatgaa tttggtggcg
    27181 tgcgcgatat cgacattccg tttgagggag ttatcaataa tatcaaacgt cgttaccatg
    27241 aaaccaatag cgattacact cgcactcaga tgcgtctcta catgaatgag ctgacctgcg
    27301 gaacctgtca aggctatcgt ctcaatgacc aggccttgtc tgtccgtgtg ggcggccagc
    27361 aagggccaca tattggagaa atctcagacc tgtctatcgc tgaccacttg gacttggtga
    27421 gccagttaac tttgtctgaa aatgaagcca tcattgctcg tcccattctc aaggaaatca
    27481 aggatcgttt gaccttcctt aataatgtgg gtcttaacta tctaaccctg tcacgttcag
    27541 caggaaccct ttcaggtggg gaaagtcagc gcattcgttt ggcaacccag attggttcca
    27601 acctatcagg cgtcctctat atcctagacg agccgtcaat cggtcttcac cagagagaca
    27661 atgaccgcct gattgccagt ctgaaaaaga tgcgtgactt gggcaatact cttatcgtgg
    27721 tggaacacga cgaagatacc atgcgtgaag ctgattatct gattgacgtt ggtcctggtg
    27781 ccggtgtttt tggtggtgag attgttgcag caggtacacc taagcaagtg gctcgcaaca
    27841 gcaagtctat cacaggtcag tacttgtcag gcaaacgtgt catcccagta ccagaagagc
    27901 gccgtgtcgg aaatggtcgt tttattgaag tgataggagc gcgtgagaac aacttgcaaa
    27961 atgtcacggc tcgctttcca ctaggaaaat ttatcgcagt gacaggtgtg tcgggttcag
    28021 ggaaatcgac tctaatcaac agcattctta aaaaagccat tgcccagaag ctcaaccgta
    28081 attcagacaa acctggtaag tttaagacta ttacagggat tgagcatgtc gaccgtttga
    28141 ttgatattga ccagagccct atcggacgga cgccgaggtc taacccagct acctatacag
    28201 gagtttttga cgatatacgt gacctttttg ctcagacaaa tgaagccaag attcgaggct
    28261 acaagaaggg gcgcttcagt ttcaacgtca agggaggtcg ctgtgaagct tgctcaggtg
    28321 acgggattat caagattgag atgcacttct tgccagatgt ttatgtggct tgtgaagttt
    28381 gccacggaac ccgctataac agtgaaaccc tagaagttca ctacaaggaa aagaatattt
    28441 cgcaggtctt ggatatgacg gtcaacgatg cggtagaatt tttccaacac attccgaaaa
    28501 ttcaacgcaa actccagacc atcaaggatg tagggctagg ctatgtgacc ttgggacagc
    28561 cagctaccac cctttctggg ggagaagccc aacgtatgaa gttagctagc gaactccaca
    28621 aacgctcgac aggaaaatct ttctacattc tggatgagcc gacgacaggg cttcatacag
    28681 aggacattgc tcgcctgctc aaggttttag ctcgctttgt agacgatggc aatacagtcc
    28741 tcgtcatcga gcacaatctg gatgttatca agacggcaga ccatatcatt gacttgggac
    28801 ctgagggcgg tgtcggtggt ggaaccatca tcgtaacagg aactccagaa gaagtagctg
    28861 ccaatgaagc cagctataca ggacactatt tgaaaggaaa gttacatcat gaataaacgc
    28921 gtacaagcat ttctagctaa aatgcaagaa aaagaactag atggtatcat catcaacaat
    28981 cttaaaaacg tctattattt gactggtttt tggggctcaa acggaacagt ctttatcagc
    29041 cgtgaccgtc aggtcttagt gacagactct cgctatatca tcgcagctaa gcaagaaacc
    29101 agtggttttg agattgtggc tgatcgtgat gaattggctg tcattgcagg aattgttaag
    29161 gacatgggct tgactcgtat cggttttgaa gatgagattt cagtatctta ttaccaccgt
    29221 atgcaggcag cttttgcagg tttggacttg cttccacaaa ctcaatttgt ggaaggtctt
    29281 cgtatgatta aggatgaggc agagattgca gcgattcgca aggcttgttc tatctcagac
    29341 caagctttcc gcgatgcgct tgactttatc aaaccaggaa aaactgaaat tgaaattgcc
    29401 aacttccttg atttccgcat gcgtgagttg ggagcatcta gcttatcttt tgatacgatc
    29461 ctagctagcg gtatcaattc ttctaaaccc catgcccatc caatgcacaa accagtggag
    29521 ttgggagaag ccattaccat ggacttcggc tgtctctatg accactatgt cagtgatatg
    29581 acccggacta tctatctagg gcatgttagc gatgagcagg cagagattta caatacggtt
    29641 ctaaaagcta accaagcctt gattgaccaa gctaaggcag gcttaggttt ccgtgacttt
    29701 gacaaaatcc ctcgtgatat tatcattgag gcaggttatg gcgactactt tactcacggc
    29761 attggccacg gtattggtct ggatatccat gaggaaccct actttagcca gacttctaca
    29821 gaaactatta agacaggtat ggccttgacc gatgaaccag gtatctatat cgaaggcaaa
    29881 tatggcgttc gtatcgagga tgatatcctg attacagaga caggttgtga attattgacc
    29941 ctagctccaa aagagttgat agtcatttag ttgtttgtca agaaaaaagt acgaaaatga
    30001 cgaaaaaagt caaaaaaaat taaaaatagg tcgcaagtcg gatgtttttt atggtataat
    30061 agactaaact gatagtaaca tgtagcgaaa ggggtaggta catgattaaa atttatacag
    30121 tctcaagttg tactagctgt aaaaaagcaa aaacctggct caatgcccac cagttaagtt
    30181 ataaagaaca aaaccttggt aaagaaggaa ttacgagaga agaattactg gatattctaa
    30241 ccaaaacaga taacggaata gccagcatcg tttcgtctaa aaatcgctat gccaaagccc
    30301 ttggagtgga tattgaagat ttgagtgtca atgaagttct caatctgatt atggaaacac
    30361 cgagaatttt aaagagccca atccttgtag atgaaaaacg cctgcaagtt ggctacaagg
    30421 aagacgatat tcgtgccttc ctaccacgct ctgtccgtaa tgtagaaaat gcagaagcac
    30481 gtttacgtgc agctctataa acatcaaggc tgggagcact tcccagtctt attctatttt
    30541 aatttcaaaa agaaagaaga gagaaatgaa aaaaatagtt cttgttagtc tagctttcct
    30601 ttttgtcctg gttggttgcg gacagaaaaa agaaactgga acagctacaa aaacagaaaa
    30661 ggatacgctt cagtcggcat tgccagttat tgaaaatgcc gagaagaata cagttgtaac
    30721 caagactttg gtcttgccca agtcagatga tggtagccag caaactcaaa ccattacata
    30781 caaggacaag acttttttga gcttaacgat tcaacaaaaa cgtccagttt ctgatgagtt
    30841 gaagatttat atcgaccaac atggagtgga agaaactcaa aaagctcttc ttgaagcgga
    30901 ggagaaggat aagtctatca ttgaagctcg taaattggca ggtttcaaac ttgaaacaaa
    30961 actattgagc gcaacggaac ttcaaacaac gactagtttt gattttcaag ttctggatgt
    31021 caagaaggct tcccagttgg aacatctgaa gaatattggt ttggaaaatc ttttgaaaaa
    31081 tgaaccaagc aaatatattt cagatagatt ggcaaatggc gcgacagaac aatagaaaat
    31141 ccaaataaat agactgcctg aattgtagaa ggtaaggaat tatgctataa tggtactatt
    31201 ctaaggaaag agggtgttag aatgggattt actgaagaaa cagtacgttt taaattggac
    31261 gattccaata aaaaagaaat tagcgaaact ttgacagatg tttatgcttc gttgaacgat
    31321 aagggttaca acccaattaa ccaaatcgta ggttacgtat tgagtggaga ccctgcctac
    31381 gttcctcgtt ataataatgc acgaaatcaa atccgtaagt atgagcgtga tgaaatcgtt
    31441 gaggaattgg ttcgctacta cctaaaagga caaggagtcg atctataacc tatgagaatt
    31501 atgggattgg acgtcggttc aaaaacggta ggggtggcga ttagcgatcc gcttggtttt
    31561 acagctcaag ggcttgaaat catccagata aatgaagaac aaggccaatt tggttttgac
    31621 cgcgttaagg aattggttga tacttacaag gtggaacgat ttgtagtggg cttgcctaaa
    31681 aacatgaaca atacaagtgg accgcgcgta gaagctagtc aagcctacgg agcaaagcta
    31741 gaagagtttt ttggtttacc agtagactat caggatgaac gcttgacaac agtggctgct
    31801 gagcgcatgt tgattgaaca agcagatatc agtcgcaata agcgcaagaa agtcattgat
    31861 aagttagcag ctcagctgat tttacaaaat tatttagata gaaaatttta atataaagga
    31921 gaggctatgt cacacgatca taaccacgac cacgaagaac gtgaactaat cacactagta
    31981 gatgagcaag gaaatgaaac cttgtttgaa atccttttga caattgatgg aaaagaagaa
    32041 tttggtaaaa actatgttct tctagtacca gttaacgcag aagaagacga agacggacaa
    32101 gttgaaatcc aagcttactc attcattgaa aatgaagatg gaacagaagg cgaattgcaa
    32161 ccaatcccag aagactcaga agacgaatgg aacatgattg aagaagtctt caacagcttt
    32221 atggaggagt aaaaacgtcc gggggacgtt tttagccctg cgctagaaat tagaaacgca
    32281 ggtagtctgg gagactgtat cagcccaact ccagaaatgg ggaagagttg gaacgtccag
    32341 tgaacatttt taccccatat tcacattcat agtagctagt tattagctaa ccaggtaaga
    32401 ggtcgggacg aaaatcctgg ccttgttttt attagtaacc atactttaat gcgataattg
    32461 attggacttt tgtcaaggag atgtgtatgt ttgaagtaga agaatggctc catagtcgga
    32521 ttggtttgaa ttttcgatca ggtttgggcc gaatgcagca agcggtggat ttgttaggaa
    32581 atcctgagca gtcttaccct attatccacg taacagggac taatgggaaa ggatctacca
    32641 ttgcttttat gagggaatta tttatggggc atggcaaaaa agttgcgacc tttacctccc
    32701 ctcatatcgt ctctatcaat gaccgaatct gcattaatgg gcaacctata gcagacgcag
    32761 actttatccg tttgactgat caggtcaagg agatggagaa aacgcttctg caaactcctg
    32821 cccagttgtc cttttttgaa ttgctgacct tagttgcttt tctttatttt agggagcaag
    32881 aggtggattt ggttttatta gaagtgggaa ttggtggctt acttgacacg accaatgtgg
    32941 taactggaga gcttgctgtc atcacctcca ttgggcttga ccatcaagaa accttgggtg
    33001 atagtctaga agcaattgca gagcagaaag ctggtatttt caaggctggt aagaaggcag
    33061 tgattgcgaa attgcctcca gaagctaggc ttgtctgtca gaaaaaagcc gaatctttag
    33121 ctgttaacct ttatcaggca ggtcaagatt ttttaatgct gaatggtgat ttttcaagct
    33181 ctttactaaa tctttcacag ctgaacatag gcttagaagg agtctatcag caggagaatg
    33241 cagccttggc gttgcaaact tttcttcttt ttatgggaga aggaaaggaa gctgttgatg
    33301 aacaggctgt aagaaaggcc ttggaacaga cccattgggc tggtcgcttg gagcgtattc
    33361 gcccacagat ttacttggat ggtgctcata acctccctgc cttgactcgc ttggttgagt
    33421 ttatcaaaga aaaagagcag gaaggctatc gacctcaaat cctttttgga gccttgaaac
    33481 ggaaggatta tcaagggatg ttaggttacc tgactgaaaa attgcctcag gtggaactca
    33541 aggtgaccgg ctttgactat cagggggctt tggacgaaag ggatgtgaca ggttacgata
    33601 tagtttcttc ttaccgagaa tttatcagcg attttgaaga aagagcagat gctcaggatt
    33661 tgctgttcgt tacagggtct ctctatttta tctcagaagt acggggctac ctgctggacc
    33721 gtgagcagat aaattgaccc ccttgtttga acttgttata ctaggggaat tgctggttag
    33781 agaaaatttc tctaaattgg tagcagaaag gaaattcatc atgaaattaa aaagattcac
    33841 actttctctt gcttctctag caagttttag tctcttagta gcttgttcac aaagagctca
    33901 acaggttcaa cagcctgctc aacagaatac caatactgca aatgcaggag gtaaccaaaa
    33961 tcaagcggct ccagtacaaa accaacctgt tgctcaaccg accgatattg atgggactta
    34021 tactggtcag gatgacggag accgtatcac tttagtggta actggaacga ctggtacatg
    34081 gactgagctc gaatctgacg gggatcagaa agtcaaacag gttacatttg attcagcaaa
    34141 tcaacgcatg attattggcg atgatgtcaa aatttacact gtaaacggta atcaaatcgt
    34201 cgtagatgat atggatagag acccatcgga ccaaatcgtt ttaactaaat aagactatgc
    34261 aagtagaaag ggctggattt ttcagccttt ttacttttac ctagaaaata atcataaata
    34321 cttgccttct accgaatacc tgcgttatac tagtatcaat tacttgtttt tagcattcaa
    34381 actatcaagg aggggatatg aaatatagga aatttcaatt attgatgtcc aagtatggct
    34441 ttagtctttc gattatgcta cttgaacttt gtcttgtttt tggtctcttt ctttatttag
    34501 gacgcatggc tcccatttta tggattactg tcctcattct actgagtatc atcacaatca
    34561 tttcgatagt caaccgtaat acgactcctg agaataaggt aacctggttg ttagtagcct
    34621 ttgtgccagt atttggtccc ttgctctatc tgatgtttgg tgaaaggcga ttgtccaaaa
    34681 aagaaatcaa acaactgaag aagctaggct ctatgcattt ccaagaagca aatagccagc
    34741 tactaaaaga gaaattaaaa gaaagtgaca aggcagctta tggagtcatc aagtccttat
    34801 tgagtatgga taccaatgct gacatctatg atcaaactgc ctctacattt tttcctaacg
    34861 gagaagctat gtggaaaaag atggtagaag atcttaaaaa ggctgagaaa tttattttct
    34921 tggaatatta cattatagaa gaaggtttga tgtggaatcg catactagat atactagagc
    34981 aaaaggtagc tcagggtgta gaggttaaga tgctctatga tgatatcggc tgtatggcta
    35041 ctttaacagg agattatgca catcgacttc gtcagctggg catcgaggcc cataaattca
    35101 ataaagttat tcctcgtttg acagtggctt ataataacag agatcataga aaaatattga
    35161 ttgttgatgg tcagatagcc tatactggtg gggtcaatct ggcagatgag tacattaacc
    35221 acgtcgagag atttggttat tggaaggata gtggaattcg cttagacgga ctagcagtaa
    35281 aagctctgac acgcttattt ttgaccactt ggtacattaa tcgaggagaa attagtgatt
    35341 ttgatcaata tcatttagaa aatcattcta tcccgagtga cggtttaacc attccatacg
    35401 gaagtggacc caagccaatt tttcgagcgc aggtagggaa aaaagtttat cagagtttaa
    35461 tcaatcaagc aacagaatcg gtctatatta cgacacctta tttgattata gattatgatt
    35521 taacagagac aatcaaaaat gcagctatga gaggggtcga tgttcgaatt atcacccctt
    35581 acataccaga taagaagttc attcagttag tcacgagagg agcttatccc gaccttcttt
    35641 ctgctggtgt tcggatttat gagtatagtc caggttttat tcatagtaag cagatgttgg
    35701 tagacgaaga ttttgcggtg gtggggacaa tcaatctcga ctaccggagc ttggtacacc
    35761 attatgaaaa tgcagtctta ctctataaaa ctccttctat aagggaaatc gcccgagatt
    35821 ttcgaaatat atttgcagat tctcaggaag tctatcctca ttctatcaaa acgagctggt
    35881 atcaaaagct tgtaaaagaa atcgcccagc tattcgcccc tatcttataa gaaatctaga
    35941 acttaggata caaaccagac ctatttttct tgtcttttac gaatagaaag aaagaggagg
    36001 ggaattcatg ctaactaagg aagaagtgaa tgatatgatt gagttcaaac ggacacattt
    36061 acaccgcttt cgggaaattg aaacctttgt gaaactatgc aaaaaatcac tcaaacagcc
    36121 atcgcaagct gacaatccta ggactttttg atatactaag acagataaat tgaacaggag
    36181 aaacgatatg agtgtgtatg gtagagtaga agaagttcat aaggagaatc gtgaacctct
    36241 agaataccaa atcgaacaag aatcgcatca tcgtgaatca agtcgtcttc ctttggtgaa
    36301 aattttacta tggagtacgc ttgtaacggg gataactcta ggagtaccgc tattactcga
    36361 cttaatgagt gcacaagaag tgcaggattt ttatgcaggt tgggcgcttc atcagacagg
    36421 gaagatttac agcgactatt atggaagtca aggtttgctt tattatttgc tgacttacgt
    36481 gagtcagggc ggatttttct ttgccatctt tgagtggtta gccttggtag caggaggatt
    36541 tttccttttt agatcagcgg acaccttgac agagcaagga gaccaagctg gacatctggt
    36601 gactattttt tacatgctag ttacaggtct tgcttttggt ggaggctatg cgactctttt
    36661 agcgcttcct ttcttattcg cagcctttag tttagttgcg gcttacctaa gcaatccaag
    36721 ccatgataag ggatttgtac ggattgggct agctttggca ggcggatttt tctttgctcc
    36781 cttatcatcg ctcctgttta ttgctgtagt gagtttaggc ttgttggtct ttaaccttgg
    36841 gcatagacgt tttgtgcatg ggttttatca gtttcttgca gtggctttag gtttttcact
    36901 tgtcttttat ccaactgcct actatagtgc tgcaacagga agttttgggg atgcgattag
    36961 tggtattcgt tatcctattg acagtattcg ctttgatttt acttctaaaa ttttagagaa
    37021 tatgtttttt tatggcttgt tgtcccttgg tttgggattt gtggtttgta tctttttagg
    37081 tctctttcaa tccaaaccct ttaaactata cgtcatttcg gttcctgcaa gtcttgtggt
    37141 aattttaggt ttgattttac ttttcttttc acaagagcct ctgcacgctt cttatttgat
    37201 ggtcgtcttc cctgttttcc tacttttatt ggtaaccaat attaagagtc aacagagggg
    37261 gcgtagtgct agaagaagcc gaagagaaac gccagttagc ctatggagtc gtttcttcaa
    37321 aggaaatcta tatctgctag tttttgggtt tgtctatctt ttgtctgttc cttttttgat
    37381 gaagtttgtc ctttatccag taccttatca agaacgtaat cgtcttgctg atttggtaaa
    37441 agaggagaca aatacggaag atgctatcta tgcatgggat gatactgcga ctctttatcg
    37501 taagagtgag cgcttgtcgc catcggcgat tttgtccccg ttgcactata cagcaactga
    37561 agaaaatcgt aataagttac ttaatgactt gaaagaaaaa caacctaagg tgattgtggt
    37621 aaatgacaag gtggtagtct ggtctgaagt ggaaacactc ttaaaagaaa attaccaaca
    37681 agtaaagact gattactcag agtttaaagt ctataaaatt aaataaccaa atcaatatct
    37741 tgtgtatttt taaaaatttt aggattttta acacaagata ttgatttttc tttttagagt
    37801 ggtataatac tttttagaaa gaacatttta gaaaagagca tgcatatgat tgcactagaa
    37861 gaaaaaatta caattttgcc aactctcttc gtcgagaaac gagatgggag acgtgttgta
    37921 tttgatgtgg acaagattga caaggctctc cacaaggcgg ctgacaaggt tatggatgtg
    37981 acacccttgg ttgaaaaacg cctcaatgat ctgactgagc gaattattac agaaattcat
    38041 agtcgctttc cacagggaat taagatttac gaaattcaaa atatcgtaga acatgaactc
    38101 cttgaagcca aagaatatgc gctggctgag gagtatatta cttatcggac acagagggat
    38161 tttgagcgct caaaagcgac ggatatcaac tttagtattc ataaacttct caacaaagac
    38221 cagacagttg tcaatgaaaa tgctaataaa gacagtgatg tctttaacac tcagcgtgat
    38281 ttgacagcag ggattgttgg gaaatcaatc ggactgcaaa tgcttcctaa gcacgtagcc
    38341 aatgcccacc aaaaggggga tatccactat cacgatttgg actacagtcc ctatacccct
    38401 atgaccaact gctgtttgat tgattttaag ggtatgttgg aaaatggttt taagattgga
    38461 aatgcagagg tagagagtcc caagtctatc cagactgcga cagcacagat ttctcaaatc
    38521 attgccaacg ttgcttctag ccagtacggt ggctgttcag ctgaccgtat cgatgaaatt
    38581 ttggcgcctt atgcagagaa gaactatcaa aaacatctca aagatgcaga agagtgggta
    38641 ttgcctgaaa aacgggaaga ttacgcttgg aagaaaacgc aaaaggacat ctacgatgcc
    38701 atgcaatctc ttgagtatga aatcaatact ctcttcactt caaatggaca aacacctttt
    38761 acttcgttag gttttggtct gggaaccagt cgttttgaac gagaaattca aaaagctatt
    38821 ttaaacattc gcatcaaggg tcttggttca gaacaccgta cggctatctt tcctaaactt
    38881 attttcactc tgaaaagagg ccttaattta gaggaaggaa ctcccaacta cgacatcaag
    38941 cagttggctc ttgagtgtgc aaccaaacgg atgtatccag atgttttatc ttacgataag
    39001 attgttgact tgacaggatc cttcaaggtg cctatgggtt gccgttcttt cctccaagga
    39061 tggaaggatg aaaatggtgt agaagtcaat tcaggtcgca tgaatctggg tgttgtgacg
    39121 gttaatctgc ctcgtattgc tcttgagtct gaaggtgata tgaataagtt ctgggaaatc
    39181 ttcaacgagc gaatgaatat cgcagaagat gctcttgttt accgtgtcga acgcactaaa
    39241 gaggcgacac cagcgaatgc tcctattctt tatcagtacg gtgcttttgg ccatcgtcta
    39301 ggtaaagaag aaagtgttga ccagctcttt aagaatcgtc gtgcgaccgt ttcgctgggc
    39361 tatatcggct tgtatgaagt agcgacagtt ttctttggta acagctggga aagtaatcca
    39421 gatgctaagg aattcacgct agacatcatt cacgatatga aacgccgtgt agaagagtgg
    39481 tcagaccaat atggctacca tttctctatc tactcaacac catccgaaag tctgacagac
    39541 cgtttctgcc gactagatat agacaagttt ggctctattc ctgatatcac agacaaggaa
    39601 tactacacca actctttcca ctacgatgtt cgtaaaaatc caacaccgtt tgaaaaattg
    39661 gactttgaga aagtctatcc agaagcaggt gcgtcaggtg gtttcatcca ttattgtgag
    39721 tatccagtcc ttcagcaaaa tccaaaggcc ttggaagctg tctgggatta tgcttatgac
    39781 cgtgtaggct atctaggcac caatactccg attgaccgtt gctacaagtg tgactttgaa
    39841 ggggattttg aaccaactga gagagggttt gcttgtccaa actgtggcaa tagcgatcct
    39901 aaaacagtag acgttgttaa acggacttgt ggctatcttg gcaatcctca agcgagaccg
    39961 atggttaacg ggcgtcacaa ggaaatcgct gcgcgtgtca aacatatgaa tggttcaacg
    40021 attaaaatag ctgggcatca agtaacaaat tagaaagaaa tgaaatggga aaatatcaac
    40081 tagacgataa ggggcgcgca caagtgaccc gttatcacga gaaatactct aaaggtggag
    40141 ctggtaagaa agaacgcttg cttagcttca gagaacaatt tttaaacaag aacaagaaaa
    40201 aataaaagtg agagccagct ctcgcttttc tcatagtggg aggtagggat ggaattacgc
    40261 agaccaagat tagcggataa gaaagctgtt ttagatatga tgacagagtt tgaaaagagc
    40321 caatcagccc atgatggagg attttgggat acagagaact ttgtgtatga agagtggttg
    40381 gaaagcaatc aggaacagga aatggggatt aatctgcctg aaggatgggt tcctgcaatt
    40441 cagttagtgg ctttttctga gaaaggtcaa gcagttggat ttcttaatct ccggttgcgc
    40501 ctcagtaact ttctactaga agaaggtggg cacattggct actccatccg tccatctgaa
    40561 agaggcaagg gttatgcaaa agagactctc cgtcagggct tgcaagttgc taaggaaaag
    40621 aacatcaaga aagctctggt gacctgtagc gtgaataatc ctgctagcag agcagtcatt
    40681 ctagcaaatg gtggaatatt tgaggatgct cgcaatggag tcgagcgtta ttggatagag
    40741 gtagcgaatg aataatccaa aaccacaaga atggaaaagc gaggaactta gtcaaggtcg
    40801 tatcattgac tacaaggcct ttaactttgt tgatggcgaa ggcgtgcgta actctctcta
    40861 tgtagcaggc tgtatgtttc actgcgaggg atgttataat gttgcgactt ggtcttttaa
    40921 tgctggcatt ccctatacag cagaattaga agagcagatc atggcagatc ttgctcagcc
    40981 ctatgttcaa ggtttgactt tgttgggagg ggagcctttt ctcaatactg gcattctctt
    41041 gccacttgtt aagcggattc ggaaagaatt gtcagacaag gacatctggt cctggaccgg
    41101 ctacacttgg gaagaaatga tgttggaaac tccagataaa ctggaactct tgtcactgat
    41161 tgatattctt gtcgatggaa gatatgatcg aactaagaga aatcttatgc tccagtttcg
    41221 aggttcgtct aaccaacgaa ttatcgatgt gcaaaaatcg ctcaaaagtg ggcaagtagt
    41281 gatttgggac aagctcaatg acggaaaaga aagctatgaa caggtgaaga gagaatgaag
    41341 aaaaaagact tagtagacca actagtctca gagatcgaga cggggaaagt caggacactg
    41401 ggaatatacg gtcatggagc ttcaggtaaa tcaacccttg cacaggaatt gtcccaagct
    41461 ttagattcta ctacagtaaa tttgtctact acagtaaatt tgctagaaac agatccctat
    41521 atcacctccg gacgctattt ggtagtaccc aaggacgcgc cgaatcaaaa ggtgacagcc
    41581 agtctgccag tggcgtatga actggagagt ttgcagagag atatccttgc cttgcaggcg
    41641 ggtatggatg tcttgacaat tgaagaacct tggaaggcta gtgaagtctt gtctggagcc
    41701 aaaccaattt tgattgtcga agggatgtct gttggttttc tacccaagga actctttgaa
    41761 aaaaccatct gtttctacac ggatgaggag accgaattaa agcgacgctt tgctagagat
    41821 acgactgtga gaaatcgcga tgcatccttt atattggcta gccatcagat gagacgggag
    41881 cagtatctgc gatactataa agaaactgag tctaaggcgg atatcttagt ggaccaatca
    41941 gaagataaat ttgatgtcaa gaggacttaa cttatgtata gaagaaaatc cctaatttta
    42001 gaaagaaaaa gtaggaaaac agtttcatcc caaaaaaacg aaaaaaccta acaaatccct
    42061 tgcaatcgca ggggatttgt gttattctat tatggtgctg taaattacag ccttagtttt
    42121 gatgcaagag gttgcgacac gctcggttgc attgccacgc aacaccgcgt cggttttctt
    42181 gtggagctag cctattatct taaatagacg aaaaggagaa aaagatggca aacaaaaaaa
    42241 tccgtatccg tttgaaagct tacgaacacc gtacgcttga cacagcggct gcaaaaatcg
    42301 tagaatcagc tactcgtaca ggtgcacaag ttgcgggtcc aatcccactt ccaactgaac
    42361 gtagcctcta cacaatcatt cgtgcgactc acaaatacaa agactctcgc gaacaatttg
    42421 aaatgcgtac acacaaacgt ttgatcgata tcgttaaccc aactcaaaaa acagttgatg
    42481 ccttgatgaa attggatctt ccaagtggtg taaacgtaga aatcaaactt taatctaaaa
    42541 tataaaagag cagaggctgg tgtttcaatc taattgaaca cgggctaaac tcggtgtgaa
    42601 aaagataaac ttcctagtgt ctgctagaca ctgcgtcagt ttcctatttt cacgttgagt
    42661 ttgacgccct ttgtatctta gacttgagca taaaaaacgc tcgttaaaaa ctttttgaat
    42721 aaaaatatag aaaaggaact attttctcat gacaaaagga atcttaggga aaaaagtggg
    42781 aatgactcaa atcttcactg aagctggcga attgatccct gtaacagtta ttgaagcaac
    42841 tccaaacgtt gttcttcaag ttaaaactgt tgaaacagac ggatacaacg ctatccaagt
    42901 tggtttcgat gacaaacgcg aagtattgag caacaaacct gctaaaggac atgtagcgaa
    42961 agctaacacg gctcctaagc gcttcattcg tgaattcaaa aacgttgaag gcttggaagt
    43021 tggtgctgaa attacagttg aaacattcgc agctggagac gttgttgacg taactggtac
    43081 ttctaaaggt aaaggtttcc aaggtgttat caaacgccac ggacaatcac gtggaccaat
    43141 ggctcacggt tctcgttacc accgtcgtcc aggttctatg ggacctgttg cacctaaccg
    43201 cgtattcaaa ggtaaaaacc ttgcaggacg tatgggtggt gaccgcgtaa caattcaaaa
    43261 tcttgaagtt gtacaagttg ttccagaaaa gaacgttatc cttatcaaag gtaacgtacc
    43321 aggtgctaag aaatctctta tcactatcaa atcagcagtt aaagctggta aataataaag
    43381 aaaggggaaa tcagtcacaa tggcaaacgt aacattattt gaccaaactg gtaaagaagc
    43441 tggccaagtt gttcttagcg atgcagtatt tggtatcgaa ccaaatgaat cagttgtgtt
    43501 tgatgtaatc atcagccaac gcgcaagcct tcgtcaagga acacacgctg ttaaaaaccg
    43561 ctctgcagta tcaggtggtg gacgcaaacc atggcgtcaa aaaggaactg gacgtgctcg
    43621 tcaaggttct atccgctcac cacaatggcg tggtggtggt gttgtcttcg gaccaactcc
    43681 acgttcatac ggctacaaac ttccacaaaa agttcgtcgc ctagctctta aatcagttta
    43741 ctctgaaaaa gttgctgaaa acaaattcgt agctgtagac gctctttcat ttacagctcc
    43801 aaaaactgct gaatttgcaa aagttcttgc agcattgagc atcgattcta aagttcttgt
    43861 tatccttgaa gaaggaaatg aattcgcagc tctttcagct cgtaaccttc caaacgtgaa
    43921 agttgcaact gctacaactg caagtgttct tgacatcgca aatagcgaca aacttcttgt
    43981 cacacaagca gctatctcta aaatcgagga ggttcttgca taatgaattt gtatgatgtt
    44041 atcaaaaaac ctgtcatcac tgaaagctca atggctcaac ttgaagcagg aaaatatgta
    44101 tttgaagttg acactcgtgc acacaaactt ttgatcaagc aagctgttga agctgctttc
    44161 gaaggtgtta aagttgccaa tgttaacaca atcaacgtaa aaccaaaagc taaacgtgtt
    44221 ggacgttaca ctggttttac taacaaaact aaaaaagcta tcatcacact tacagctgat
    44281 tctaaagcaa tcgagttgtt tgctgctgaa gctgaataat ctaaggagga aatatcgtgg
    44341 gaattcgtgt ttataaacca acaacaaacg gtcgccgtaa tatgacttct ttggatttcg
    44401 ctgaaatcac aacaagcact cctgaaaaat cattgcttgt tgcattgaag agcaaggctg
    44461 gtcgtaacaa caacggtcgt atcacagttc gtcaccaagg tggtggacac aaacgtttct
    44521 accgtttggt tgacttcaaa cgtaataaag acaacgttga agcagttgtt aaaacaatcg
    44581 agtacgatcc aaaccgttct gcaaacatcg ctcttgtaca ctacactgac ggtgtgaaag
    44641 catacatcat cgctccaaaa ggtcttgaag taggtcaacg tatcgtttca ggtccagaag
    44701 cagatatcaa agtcggaaac gctcttccac ttgctaacat cccagttggt actttgattc
    44761 acaacatcga gttgaaacca ggtcgtggtg gtgaattggt acgtgctgct ggtgcatctg
    44821 ctcaagtatt gggttctgaa ggtaaatacg ttcttgttcg tcttcaatca ggtgaagttc
    44881 gtatgattct tggaacttgc cgtgctacag ttggtgttgt cggaaacgaa caacatggac
    44941 ttgtaaacct tggtaaagca ggacgtagcc gttggaaagg tatccgccca acagttcgtg
    45001 gttctgtaat gaaccctaac gatcacccac acggtggtgg tgaaggtaaa gcaccagttg
    45061 gtcgtaaagc accatctact ccatggggca aacctgctct tggtcttaaa actcgtaaca
    45121 agaaagcgaa atctgacaaa cttatcgttc gtcgtcgcaa cgagaaataa tattaaacta
    45181 gtcgcttaag caactagtaa atccgccagc tcggtagcgc tccataggag tgcaagccgc
    45241 tgtggtacaa catttaaagg agaaaatata aaaatgggac gcagtcttaa aaaaggacct
    45301 ttcgtcgatg agcatttgat gaaaaaagtt gaagctcaag ctaacgacga aaagaaaaaa
    45361 gttattaaaa cttggtcacg tcgttcaacg atcttcccaa gtttcattgg ttacactatt
    45421 gcagtttatg acggacgtaa acacgtacct gtttacatcc aagaagacat ggtaggccac
    45481 aaacttggtg aatttgcacc aactcgtact tacaaaggtc acgctgcaga cgacaagaaa
    45541 acacgtagaa aataaggaga acataaatgg cagaaattac ttcagctaaa gcaatggctc
    45601 gtacagtacg tgtttcacct cgtaaatcac gtcttgttct tgataacatc cgtggtaaaa
    45661 gcgtagccga tgcaatcgca atcttgacat tcactccaaa caaagctgct gaaatcatct
    45721 tgaaagtttt gaactcagct gtagctaacg ctgaaaacaa ctttggtttg gataaagcta
    45781 acttggtagt atctgaagca ttcgcaaacg aaggaccaac tatgaaacgt ttccgtccac
    45841 gtgcgaaagg ttcagcttca ccaatcaaca aacgtacagc tcacatcact gtagctgttg
    45901 cagaaaaata aggaggtaaa atcgtgggtc aaaaagtaca tccaattggt atgcgtgtcg
    45961 gcatcatccg tgattgggat gccaaatggt atgctgaaaa agaatacgcg gattaccttc
    46021 atgaagatct tgcaatccgt aaattcgttc aaaaagaact tgctgacgca gcagtttcaa
    46081 ctattgaaat cgaacgcgca gtaaacaaag ttaacgtttc acttcacact gctaaaccag
    46141 gtatggttat cggtaaaggt ggtgctaacg ttgatgcact ccgtgcaaaa cttaacaaat
    46201 tgactggaaa acaagtacac atcaacatca tcgaaatcaa acaacctgat ttggatgctc
    46261 accttgtagg tgaaggaatt gctcgtcaat tggagcaacg tgttgctttc cgtcgtgcac
    46321 aaaaacaagc aatccaacgt gcaatgcgtg ctggagctaa aggaatcaaa actcaagtat
    46381 caggtcgttt gaacggtgca gatatcgccc gtgctgaagg atactctgaa ggaactgttc
    46441 cgcttcacac acttcgtgca gatatcgatt acgcttggga agaagcagat actacatacg
    46501 gtaaacttgg tgttaaagta tggatctacc gtggtgaagt tcttccagct cgtaaaaaca
    46561 ctaaaggagg taaataacca atgttagtac ctaaacgtgt taaacaccgt cgtgaattcc
    46621 gtggaaaaat gcgcggtgaa gcaaaaggtg gaaaagaagt agcattcggt gaatacggtc
    46681 ttcaagctac aactagccac tggatcacta accgccaaat cgaagctgct cgtatcgcca
    46741 tgactcgtta catgaaacgt ggtggtaaag tttggattaa aatcttccca cacaaatcat
    46801 acactgctaa agctatcggt gtgcgtatgg gatctggtaa aggggcacct gaaggttggg
    46861 tagcaccagt taaacgtggt aaagtgatgt tcgaaatcgc tggtgtatct gaagagattg
    46921 cacgtgaagc gcttcgactt gctagccaca aattgccagt taaatgtaaa ttcgtaaaac
    46981 gtgaagcaga ataaggagaa ggcatgaaac ttaatgaagt aaaagaattt gttaaagaac
    47041 ttcgtggtct ttctcaagaa gaactcgcga agcgcgaaaa cgaattgaaa aaagaattgt
    47101 ttgaacttcg tttccaagct gctactggtc aattggaaca aacagctcgc ttgaaagaag
    47161 ttaaaaaaca aatcgctcgt atcaaaacag ttcaatctga agcgaaataa tagactaggg
    47221 aaggagaaat ttcaatggaa cgcaataatc gtaaagttct tgttggacgt gttgtatctg
    47281 acaaaatgga caagacaatc acagttgtag ttgaaacaaa acgtaaccac ccagtctatg
    47341 gtaaacgtat taactactct aaaaaataca aagctcatga tgaaaacaat gttgccaaag
    47401 aaggtgatat cgtacgtatc atggaaactc gcccgctttc agctacaaaa cgtttccgtc
    47461 ttgtagaagt tgttgaagaa gcggtcatca tctaatcaaa cctgaaagga gaaaactgaa
    47521 atgattcaaa cagaaactcg tttgaaagtc gcagacaaca gcggtgctcg cgaaatcttg
    47581 actatcaaag ttcttggtgg ttcaggacgt aaatttgcaa acatcggtga tgttatcgtg
    47641 gcatctgtaa aacaagctac tcctggtggt gcggttaaaa aaggtgacgt tgttaaagca
    47701 gttatcgttc gtactaaatc aggtgctcgt cgtgctgatg gttcatacat caaatttgac
    47761 gaaaacgcag cagttatcat ccgtgaagac aaaactcctc gcggaacacg tatctttggc
    47821 ccagttgcac gtgaattgcg tgaaggtggt ttcatgaaga tcgtgtcact tgctccagaa
    47881 gtactttaat ttttaggaac aaactagtcc cctagcttca agctagggtg cccttatggg
    47941 cgtaagaaaa atcaaggaga aacctaatgt ttgtaaaaaa aggcgacaaa gttcgcgtaa
    48001 tcgctggtaa agataaggga acagaagctg ttgtccttac tgcccttcca aaagtaaaca
    48061 aagttatcgt tgaaggtgtt aacattgtta agaaacacca acgtccaact aacgagcttc
    48121 ctcaaggtgg tatcatcgag aaagaagcag ctatccacgt atcaaatgtt caagttttgg
    48181 acaaaaatgg tgtagctggt cgtgttggtt acaaatttgt agacggtaaa aaagttcgct
    48241 acaacaaaaa atcaggcgaa gtgcttgatt aatcacgaag gaaaggagaa gtataatggc
    48301 aaatcgttta aaagaaaaat atcttaatga agtagttcct gctttgacag aacaattcaa
    48361 ctactcatca gtgatggctg tgcctaaagt agataagatt gttttgaaca tgggtgttgg
    48421 tgaagctgta tcaaacgcta aaagccttga aaaagctgct gaagaattgg cacttatctc
    48481 aggtcaaaaa ccacttatca ctaaagctaa aaaatcaatc gccggcttcc gtcttcgtga
    48541 aggtgttgcg atcggtgcaa aagttaccct tcgtggtgaa cgtatgtacg aattcttgga
    48601 taaattggta tcagtttcac ttccacgtgt acgtgacttc cacggtgtcc caacaaaatc
    48661 atttgatgga cgcgggaact acacacttgg tgtgaaagaa caattaatct tcccagaaat
    48721 caacttcgat gacgttgaca aaactcgtgg tcttgacatc gttatcgtaa caactgctaa
    48781 cactgacgaa gagtcacgtg cattgcttac aggccttgga atgccttttg caaaataata
    48841 taggaggtaa atctaatggc taaaaaatca atggtagcta gagaggctaa acgccaaaaa
    48901 attgttgacc gttatgctga aaaacgtgct gcattaaagg cggcagggga ctacgaaggt
    48961 ttatctaaat tacctcgcaa cgcctcaccg actcgtttac ataatcgttg tagagttacg
    49021 gggcgcccac attcagttta ccgcaaattt ggtctgagtc gtatcgcttt tcgcgaactt
    49081 gcgcataaag gtcaaattcc tggtgtaaca aaagcatctt ggtaatttaa gatatcaagg
    49141 gtgtcaaaac tccaagtaaa aataggaaac ttgacgaaga aactaaagtt tctaggaaag
    49201 tttatctttt tcacacagag tttagcccgg gttcaattgg gcttgccaat ttgaacccga
    49261 gctacagctt tggcaaaaaa gaccaatttg ctttggagca ttgcttctgc attaaattgt
    49321 ctatttttgc tcgtgctgtt acgctctttg tatcatgtat taactagcaa gtgcaacttg
    49381 caaactacta gtaagaggag aaaaacaaaa tggttatgac tgacccaatc gcagacttcc
    49441 taactcgtat tcgtaatgct aaccaagcta aacacgaagt acttgaagta cctgcatcaa
    49501 acatcaaaaa agggattgct gaaatcctta aacgcgaagg ttttgtaaaa aacgttgaaa
    49561 tcattgaaga tgacaaacaa ggcgtcatcc gtgtatttct taaatacgga tcaaatggtg
    49621 agaaagttat cactaacttg aaacgtgttt ctaaaccagg acttcgtgtc tacaaaaaac
    49681 gtgaagacct tccaaaagtt cttaacggac ttggaattgc catcctttca acttctgaag
    49741 gtttgcttac tgataaagaa gcacgccaaa agaatgttgg tggtgaggtt atcgcttacg
    49801 tttggtaaaa tcaagataca aagctcgtaa agaacaaagc aaaattagga agttggagaa
    49861 gtttgtttac aaacaagcca acttatctat tttgcacagt tcttagagcg tgttcagttc
    49921 agctcttgaa ctaaataagt atctgaaccc cgtgaaaact ggccgttctg gcctgacaat
    49981 ttaacaggag aaaataaaca tgtcacgtat tggtaataaa gttatcgtgt tgcctgctgg
    50041 tgttgaactc gctaacaatg acaacgttgt aactgtaaaa ggacctaaag gagaacttac
    50101 tcgtgagttc tcaaaagata ttgaaatccg tgtggaaggt actgaaataa ctcttcaccg
    50161 tccaaacgat tcaaaagaaa tgaaaactat ccacggaact actcgtgccc ttttgaacaa
    50221 catggttgtt ggtgtatcag aaggattcaa gaaagaactt gaaatgcgtg gggttggtta
    50281 ccgtgcacag cttcaaggat ctaaacttgt tttggctgtt ggtaaatctc atccagacga
    50341 agttgaagct ccagaaggaa ttacttttga acttccaaac ccaacaacaa tcgttgttag
    50401 cggaatttca aaagaagtag ttggtcaaac agctgcttac gtacgtagcc ttcgttcacc
    50461 agaaccatat aaaggtaaag gtatccgtta cgttggtgaa ttcgttcgcc gtaaagaagg
    50521 taaaacaggt aaataatgtt gagtggttga tcatcaacca ccaacctatt ttccaacttt
    50581 gtgcatagca cacgatttaa aactaaagag gtgaaaactg tgatttcaaa accagataaa
    50641 aacaaactcc gccaaaaacg ccaccgtcgc gttcgcggaa aactctctgg aactgctgat
    50701 cgcccacgtt tgaacgtatt ccgttctaat acaggcatct acgctcaagt gattgatgac
    50761 gtagcgggtg taacgctcgc aagtgcttca actcttgata aagaagtttc aaaaggaact
    50821 aaaactgaac aagccgttgc tgtcggtaaa ctcgttgcag aacgtgcaaa cgctaaaggt
    50881 atttcagaag tggtgttcga ccgcggtgga tatctatatc acggacgtgt gaaagctttg
    50941 gctgatgcag ctcgtgaaaa cggattgaaa ttctaatagg aggacactag aaaatggcat
    51001 ttaaagacaa tgcagttgaa ttagaagaac gcgtagttgc tgtcaaccgt gttacaaaag
    51061 ttgttaaagg tggacgtcgt cttcgtttcg cagctcttgt tgttgttggt gaccacaatg
    51121 gtcgcgtagg atttggtact ggtaaagctc aagaagttcc agaagcaatc cgtaaagcag
    51181 tagatgatgc taagaaaaac ttgatcgaag ttcctatggt tggaacaaca atcccacacg
    51241 aagttctttc agaattcggt ggagctaaag tattgttgaa acctgctgta gaaggttctg
    51301 gagttgccgc tggtggtgca gttcgtgccg ttgtggaatt ggcaggtgtg gcagatatta
    51361 catctaaatc acttggttct aacactccaa tcaacattgt tcgtgcaact gttgaaggtt
    51421 tgaaacaatt gaaacgcgct gaagaaattg ctgcccttcg tggtatttca gtttctgatt
    51481 tggcataaga aaggggataa aatggctcaa attaaaatta ctttgactaa gtctccaatc
    51541 ggacgcattc catcacaacg taaaactgtt gtagcacttg gacttggcaa attgaacagc
    51601 tctgttatta aagaagataa cgctgctatc cgtggtatga ttacagcagt atctcactta
    51661 gtaacagttg aagaagtaaa ctaatgaagt tttaggggat gtgcactgta ccatccccta
    51721 aaactagata tagtcatcta tgatgacatc gtataggcga gttgatgggg gagacaacct
    51781 tttctccctt atcggcgcta gcattttaca aaagaggaga aaataaaaat gaaacttcat
    51841 gaattgaaac ctgcagaagg ttctcgtaaa gtacgtaacc gcgttggtcg tggtacttca
    51901 tcaggtaacg gtaaaacatc tggtcgtggt caaaaaggtc aaaaagctcg tagcggtggc
    51961 ggagttcgcc ttggttttga aggtggacaa actccattgt tccgtcgtct tccaaaacgt
    52021 ggattcacta acatcaacgc taaagaatac gcaattgtga accttgacca attgaacgtc
    52081 tttgaagatg gtgctgaagt aactccagtt gttcttatcg aagcaggaat tgttaaagct
    52141 gaaaagtcag gtattaaaat tcttggtaac ggtgagttga ctaagaaatt gactgtgaaa
    52201 gcagctaaat tctctaaatc agctgaagaa gctatcactg ctaaaggtgg ttcagtagaa
    52261 gtcatctaag agaggtgacc tatgtttttt aaattattaa gagaagctct taaagtcaag
    52321 caggttcgat caaaaatttt atttacaatt tttatcgttt tggtctttcg tatcggaact
    52381 agcattacag ttcctggtgt gaatgccaat agcttgaatg ctttaagtgg attatccttc
    52441 ttaaacatgt tgagcttggt gtcggggaat gccctaaaaa acttttcgat ttttgcccta
    52501 ggagttagtc cctatatcac cgcttctatt gttgtccaac tcttgcaaat ggatatttta
    52561 cccaagtttg tagagtgggg taaacaaggg gaagtaggtc gaagaaaatt gaatcaagct
    52621 actcgttata ttgctctagt tctcgctttt gtgcaatcta tcgggattac agctggtttt
    52681 aataccttgg ctggagctca attgattaaa actgctttaa ctccacaagt ttttctgacg
    52741 attggtatca tcttaacagc tggtagtatg attgtcactt ggttgggtga gcaaattaca
    52801 gataagggat acggaaacgg tgtttccatg attatctttg ccgggattgt ttcctcaatt
    52861 ccagagatga ttcagggcat ctatgtggac tactttgtga acgtcccaag tagccgtatc
    52921 acttcatcta tcattttcgt aatcattttg attattactg tattgttgat tatttacttt
    52981 acaacttatg ttcaacaagc agaatacaaa attccaatcc aatatactaa ggttgcacaa
    53041 ggtgctccat ctagctctta ccttccgtta aaggtaaacc ctgctggagt tatccctgtt
    53101 atctttgcca gttcgattac tgcagcgcct gcggctattc ttcagttttt gagtgccaca
    53161 ggtcatgatt gggcttgggt aagggtagca caagagatgt tggcaactac ttctccaact
    53221 ggtattgcca tgtatgcttt gttgattatt ctctttacat tcttctatac gtttgtacag
    53281 attaatcctg aaaaagcagc agagagccta caaaagagtg gtgcctatat ccatggagtt
    53341 cgtcctggta aaggtacaga agaatatatg tctaaacttc ttcgtcgtct tgcaactgtt
    53401 ggttccctct tccttggtgt gatttccatt ttaccgattg cagctaaaga tgtatttggt
    53461 ctttctgatg ttgttgcctt tggtggaaca agtctcttga tcattatctc tacaggtatc
    53521 gaaggaatca agcaattgga aggttaccta ttgaaacgta agtatgttgg tttcatggac
    53581 agaacagaat aaaagtattt actgaatcag taaatactga gggagtggag gtttaaactc
    53641 tgacatttgt aagagttgga tctcccctct tctattttgt ttttaaatag gggtgaaaag
    53701 actttttgct tctatttaaa aataaaataa ggagatcaaa tcatgaatct tttgattatg
    53761 ggcttacctg gtgcaggtaa gggaactcaa gcagcaaaaa tcgtagaaca attccatgtt
    53821 gcacatatct caacaggtga tatgttccgc gctgcaatgg caaatcaaac tgaaatgggt
    53881 gttcttgcta agtcatatat tgacaagggt gaattggttc ctgacgaagt tacaaatgga
    53941 atcgtaaaag aacgcctttc acaagatgat attaaagaaa caggattctt attggatggt
    54001 tacccacgta caattgaaca agctcatgcc ttggacaaaa cattggctga acttggcatt
    54061 gaactagaag gtgttatcaa tattgaagtg aaccctgaca gcctcttgga acgtttgagt
    54121 ggccgtatca tccaccgcgt aactggagaa actttccaca aggtctttaa cccaccagtt
    54181 gactataaag aagaagatta ctaccaacgt gaagatgata agcctgagac agtaaaacgt
    54241 cgtttggatg ttaatattgc tcaaggagaa ccaatcattg ctcactaccg tgccaaaggt
    54301 ttggttcatg acatcgaagg taatcaagat atcaatgatg tcttctcaga tattgaaaaa
    54361 gtattgacaa atttgaaata aagcgttttt cacacttgca aaaatccgct acaaatgtta
    54421 tactgagata gtctgactta taattgttgt ctctgtgtct agaggcatcg aatcgaaatt
    54481 tatggaggtg cttttgcgtg gcaaaagacg atgtgattga agttgaaggc aaagtagttg
    54541 atacaatgcc gaatgcaatg tttacggttg aacttgaaaa tggacatcag attttagcaa
    54601 cagtttctgg taaaattcgt aaaaactata ttcgtatttt agcgggagat cgtgttactg
    54661 tcgaaatgag tccatatgac ttgacacgtg gacgtatcac ttaccgcttt aaataatcga
    54721 aaaacttgga gggataagaa atgaaagtaa gaccatcggt caaaccaatt tgcgaatact
    54781 gtaaagttat tcgtcgtaat ggtcgtgtta tggtaatttg cccagcaaat ccaaaacaca
    54841 aacaacgtca aggataagat agaaaggaga aaacatggct cgtattgctg gagttgatat
    54901 tccaaatgac aaacgcgtag taatctcatt gacttatgtt tatggtatcg gacttgcaac
    54961 atctaagaaa attttggctg ctgctggaat ctcagaagat gttcgtgtac gtgatcttac
    55021 atcagatcaa gaagatgcta tccgtcgtga agtggatgca atcaaagttg aaggtgacct
    55081 tcgtcgtgaa gtaaacttga acatcaaacg tttgatggaa atcggttcat accgtggtat
    55141 ccgtcaccgt cgtggacttc ctgtccgtgg acaaaacact aaaaacaacg ctcgcactcg
    55201 taaaggtaaa gctgttgcga ttgctggtaa gaaaaaataa tataggaggt aaaagtcttg
    55261 gctaaaccaa cacgtaaacg tcgtgtgaaa aagaatatcg aatctggtat tgctcatatt
    55321 cacgctacat ttaataacac tattgttatg attactgatg tgcatggtaa tgcaattgct
    55381 tggtcatcag ctggtgctct tggtttcaaa ggttctcgta aatctacacc attcgctgct
    55441 caaatggctt ctgaagctgc tgctaaatct gcacaagaac acggtcttaa atcagttgaa
    55501 gttactgtaa aaggtccagg ttctggtcgt gagtcagcta ttcgtgcgct tgctgccgct
    55561 ggtcttgaag taacagcaat tcgtgatgtg actccagtgc cacacaatgg tgctcgtcct
    55621 ccaaaacgtc gccgtgtata atcatcgcat tacactgctt ttcgtttaag agggagtaac
    55681 taaatgatcg agtttgaaaa accaaatata acaaaaattg atgaaaataa agattatggc
    55741 aagtttgtaa tcgaaccact tgaacgtggc tacggtacaa ctcttggtaa ctctcttcgt
    55801 cgtgtacttc tagcttctct accaggagca gctgtgacat ctatcaacat tgatggtgtg
    55861 ttacatgagt ttgacacagt tccaggtgtt cgtgaagacg tgatgcaaat cattctgaac
    55921 attaaaggaa ttgcagtgaa atcgtacgtt gaagacgaaa aaatcatcga actggatgtt
    55981 gaaggtcctg ctgaagtaac agctggtgac attttgacag atagcgatat tgaaattgta
    56041 aatccagatc attatctctt tacaatcggt gaaggttctt ctctaaaagc gactatgact
    56101 gttaacagtg gtcgtggata tgtacctgct gatgaaaata aaaaggataa tgcaccagtt
    56161 ggaacacttg ctgtagattc tatttataca ccagttacaa aagtcaacta tcaagtggaa
    56221 cctgctcgtg taggtagcaa tgatggtttc gacaaattaa cccttgaaat cttgacaaat
    56281 ggaacaatta ttccagaaga tgctttaggg ctttcagcac gtattttgac agaacatctt
    56341 gatttgttta caaatcttac tgagattgct aagtcaactg aagtgatgaa agaagctgat
    56401 actgaatctg acgaccgtat tttagatcgt acgattgagg aactggactt gtctgtgcgt
    56461 tcatacaact gtttaaaacg tgccggtatc aatactgtgc atgatttgac agaaaaatct
    56521 gaagcagaga tgatgaaagt acgaaatctt ggacgcaaga gtttggaaga agtgaaactc
    56581 aaactcattg atttgggtct tggattaaaa gataaataaa ggaggaatac atggcttacc
    56641 gtaaactagg acgcactagc tcacaacgta aagcaatgct tcgcgatttg acaactgacc
    56701 ttttgatcaa cgaatcaatc gtgacaactg aagctcgtgc taaagaaatc cgtaaaactg
    56761 ttgaaaaaat gattactcta ggtaaacgtg gtgatttgca tgcacgtcgt caagcagctg
    56821 ctttcgtacg taatgaaatc gcatctgaaa actatgatga agcaactgat aagtacactt
    56881 ctactacagc acttcaaaaa ttgttctcag aaatcgcacc tcgttatgct gaacgtaacg
    56941 gtggatacac tcgtatcctt aaaactgaac cacgtcgtgg tgatgcagcg ccaatggcga
    57001 tcatcgaatt agtataaaat catcaatttt gttgagtgtt atgatgatgg agtcttgtgc
    57061 tcttagtcta gctctggtct accgctagga tttcggtcct agcgggaaca ctcatcataa
    57121 gttgggatag tagacgcttg tttacgaaat tgtttttttc ttaagaacaa cttcgtaagc
    57181 aggcgttttt gagtattttc gttagaatta tgctatacta tttgaaaaga atcctgttta
    57241 atgttaaggt ttcttatttt aagaagaatt ggagtttact tatgaaagcg attataactg
    57301 ttgttggtaa agataaatct ggaattgttg caggtgtttc tggtaaaatt gcagaattag
    57361 gattgaatat tgacgatatc tctcaaactg tattggatga atattttacg atgatggctg
    57421 ttgtatctag tgatgaaaag caagatttta cctatcttcg taatgaattt gaagcttttg
    57481 ggcaaacttt gaatgtaaaa atcaatattc agagtgcagc gattttcgaa gctatgtata
    57541 atatctagga ggtcatcatg gatattagac aagttactga aaccatcgcc atgattgagg
    57601 agcaaaactt cgatattaga accattacca tggggatttc tcttttggac tgtatcgatc
    57661 caaatatcaa tcgtgctgcg gagaaaatct atcaaaaaat tacgacaaag gcggctaatt
    57721 tagtagctgt tggtgatgaa attgcggctg agttgggaat tcctatcgtt aataagcgtg
    57781 tatcggtgac acctatttct ctgattgggg cagcgacaga tgcgacggac tacgtggttc
    57841 tggcaaaagc gcttgataag gctgcgaaag agattggtgt ggactttatt ggtggttttt
    57901 ctgccttagt acaaaaaggt tatcaaaagg gagatgagat tctcatcaat tccattcctc
    57961 gcgctttggc tgagacggat aaggtctgct cgtcagtcaa tatcggctca accaagtctg
    58021 gtattaatat gacggctgtg gcagatatgg gacgaattat caaggaaaca gcaaatcttt
    58081 cagatatggg agtggccaag ttggttgtat tcgctaatgc tgttgaggac aatccattta
    58141 tggcgggtgc ctttcatggt gttggggaag cagatgttat catcaatgtc ggagtttctg
    58201 gtcctggtgt tgtgaaacgt gctttggaaa aagttcgtgg acagagcttt gatgtagtag
    58261 ccgaaacagt taagaaaact gcctttaaaa tcactcgtat cggtcaattg gttggtcaaa
    58321 tggccagtga gagactgggt gtggagtttg gtattgtgga cttgagtttg gcaccaaccc
    58381 ctgcggttgg agactctgtg gcacgtgtcc ttgaggaaat ggggctagaa acagttggca
    58441 cgcatggaac gacggctgcc ttggccctct tgaacgacca agttaaaaag ggtggagtga
    58501 tggcctgcaa ccaagtcggt ggtttatctg gtgcctttat ccctgtttct gaggatgaag
    58561 gaatgattgc tgcagtgcaa aatggctctc ttaatttaga aaaactagaa gctatgacgg
    58621 ctatctgttc tgttggattg gatatgattg ccatcccaga agatacgcct gctgaaacca
    58681 ttgcggctat gattgcggat gaagcagcaa tcggtgttat caacatgaaa acaacagctg
    58741 ttcgtatcat tcccaaagga agagaaggcg atatgattga gtttggtggt ctattaggaa
    58801 ctgcacccgt tatgaaggtt aatggggctt catctgtcga cttcatctct cgcggtggac
    58861 aaatcccagc accaattcat agttttaaaa attaagaaaa taggagaaat tttaagttct
    58921 atttaagatt agatgtgtat actataatca ttaaataaag acctcctaat attatttgaa
    58981 acagataaca ctgaattagt ttgaatttga ttttcatcta atatctttat ttaatgaact
    59041 cctaaacttt ttcataataa tctccttcaa aagtcgcctg tatgggtggc ttttatttta
    59101 tcattcatga tataatagaa gcaaacggag gacggaaaat ggtaaaagta cgattgtatt
    59161 tggtacgtca tggcaagacc atgtttaaca cgattggtcg cgcgcaaggt tggagcgata
    59221 ctcccttaac tgctgaaggt gaacgaggga ttcaagagtt aggaattggt ttgcgagaat
    59281 ctgatctaca gtttgagcgc gcttattcga gtgattctgg tcgtaccatt cagaccatgg
    59341 gaattatcct tgaagagctt ggcttgcagg ggaaaatccc ttatcgcatg gacaagcgta
    59401 tcagagaatg gtgtttcggt agttttgatg gagcctatga tggcgatctt ttcatgggca
    59461 ttattcctcg tatctttaat gtggaccacg ttcaccaatt gtcttatgct gaactggctg
    59521 agggcttggt agaggtcgat acagctggtt gggctgaagg ctgggaaaaa ctcagtggcc
    59581 gaattaagga aggctttgaa atgattgcaa aagaaatgga agatcaaggt ggaggtaacg
    59641 cccttgttgt cagccatgga atgactattg gaaccattgt ttatctgatt aatggcatgc
    59701 atccgcatgg tctagataat ggtagcgtga cgattcttga atatgaggac ggtcagttta
    59761 gggttgaagt tgtcggtgac cgtagttacc gagagctagg acgtgagaag atggaagaag
    59821 gctctattta atcagtctag acttgcttgc catgagctag ggatttgata agaatatcaa
    59881 gataagaaaa aacagccgag ggtactcctt tcggctgttt ttgatgtgga aaactaaagt
    59941 gtaatgctat tgcttttaga gattttcata aacaagagca aggaacctac tgttagaaca
    60001 gtcaggatag ttgacaaggc tgcggctaca ccgtaatttc ctctgagaac ctctgtataa
    60061 atagctacag tcattgttct tgttttgaca ttgtagagga ggatagagga tagaagtaga
    60121 gagttctgaa atcagtgtga cccaagatag gatggctcca gaaataatac ccgatagcat
    60181 cattggagtt gtaatcttag caaaggtatt gagacgacta cttcctaagc tttcagcagc
    60241 ttcttcaata cttggtgcta tttgttgtaa gctagcaaca gatgagcgaa tagtataagg
    60301 taatcttctg acagatagag acataatcaa gatgaaagca gtccctgtaa tcataagaaa
    60361 tccacttcca aatagaccag tattgaagga agaaatgaag gcaatcccta gaacggttcc
    60421 tgatacaata taaggtacca tactgaggct gtcaattaag tttgtaaaca aattccgttt
    60481 tctaacggct aggtaggaga taaatgtcgc aaatagaaca actagaacta aggcaatcaa
    60541 agggatacga atggtattga aaatagcaga tcccatacga ttgaaagcta ccttgtaact
    60601 gtttggagaa taacctttaa caaataccat acctgatgtt tttaggaaag aggtataaat
    60661 taagtagatt tgaggtaaaa cagagataaa gataattccg tagactgttg cataaatggc
    60721 agccattttt ccttttgtag tttttttagg ctcaattgga tggagcggat tcatgctgaa
    60781 actgtagcgg tttgcaatgt gtttttggat aaggaaaatt gccaaggcaa tgataatcgc
    60841 cataattgca aaagcagaat ttcctccaac ctcgctaata aattgggtat aaatcaggac
    60901 agggaaagtc cgatatcctt cgccaatcaa cataggcgtt ccaaagtctg agaatgctct
    60961 cataaataca agcaaggagc tgctagtaag gttggaacta gaagaggtaa aacaaccgtt
    61021 acgataggtt taaatccgaa ggaccccatg ctttcagctg cttcaagtag agaattgtca
    61081 atactgttca ttgttccagc aacatataga aataccagtg ggaatagttg cagtgtaaag
    61141 acaagtacaa ttcctttgaa tccataaata tcgatagctg gaagatgaag ggcatttgtc
    61201 aaaaatttag tgatgccccc atttcgtccc agcaagagaa cccaggagta ggctcctacg
    61261 aaaggagctg acatggaagc aatgataatc aatatttgta gaaatttctt ccccttgaag
    61321 tcatacatag agaagagata agctaatagg gttcctacaa ctaaggaagt gacagtagcg
    61381 gtaatggaaa ccctgaaact gttgactagt gtctcagagt agtaggcttt actaaagaaa
    61441 gtgacaaaat tagatagtga gaattgtcct tcatgtataa gtgcttgctt gagcacggta
    61501 acgataggat aaacgagaaa gacaagatag gtaagaaaga tgaagaaaga ggaggctgtc
    61561 caaatattta gttttttaca ttccatggtt gactcctttt atcaggtttt gggaaccatc
    61621 tacagaaaag atgtttaatt tttgcgtatt gattcgtaga cgaatacgat tgcctttttg
    61681 tagttcttct tcaaaagttg attcttcact aacttaaatt tttgaggcaa aacctgtctc
    61741 aatgaaatac tccgtattta gtccaagata gacgctatcg ctaatagttc cttcgatatc
    61801 tccagattca tctttgataa actcttcggg acgaatgctt acatgaatag cttgctcctc
    61861 aacctgatca agagctggca ttcgaagggc atagccatct gaaaagacga tataagcgcc
    61921 gtcgctccgt ttttcaagat tggcagggat aatatttgtg cgtccgataa aggttgccac
    61981 aaactcatta gctggtttat gatagagtta ttttggtcgg ccgatttgtt ggatcacccc
    62041 atctttcata acagcaattt ggtctgaaat agccatggct tcttcttggt cgtgggttac
    62101 ataaacagtt gtaattccca cttcgtgttg gatttctcgg atggcttgac gcatatccaa
    62161 gcgaagtttg gcctccagat tactaagtgg ctcgttcatg aggagaacac ttggattaac
    62221 cgctaaggcg catgccaagg tgacacgttg ttgttgtcca ccactgagtt tatcgggctt
    62281 tcgatccgca tattgagcaa tttgcatgag ttcaagatac ttgttggtct gttgaatcaa
    62341 ttcttctttt ggaaccttct tttgcataag accaaaagca acgttgtctc ggacagtcaa
    62401 atgtgggaaa atagcgtagt tttggaaaac catcccgata ttgcgtttgc tgggttccat
    62461 attattgatt tttgtatcat cgaagtaaaa ttctccacct tcgatactgt tgaaacctgc
    62521 aatcatacga agaagggtcg ttttcccaca tcctgaaggt ccaagaaggg taaagagact
    62581 tccttttgga attgtaatgt tcaaattctc aataacaggg acatcgtggt agattttttt
    62641 ggcgttaata attttgatct cactcatagt gaacctcttt tactgtttag attggatatc
    62701 tgtaaagact tcgttgtatt tcttaacgat atctgattta ttcttgatga cataatcata
    62761 atcttcagtg agtgttttga ttttgtcaat tggtttcatg ttttcgcttg ttttagcatt
    62821 tttacgaaca ggacggttag tagtggttgt accaagtgta tcttgtactt cttgagagat
    62881 aataaaatcg ataaatttct tggcattttc catattttta gattttttaa cgatagcagc
    62941 actagcaggt aggaagacgg ttccttcttt tggatagact accttaatgt tagctccgtc
    63001 atttaagagt ttaactgctg gatcttcata agagagacca acagtcattt ctccatcagc
    63061 gactgcttta tagacaccag atgaacttaa accgatttta tagtatattg aaactagaat
    63121 agtacacatc tacttctaaa acattgttag aaatcgattt gactgtcctg attaatttgt
    63181 cttgttctta tttcatttta ctataccatc aataagtgtg aaaagatctt ttacataaga
    63241 ccaagcctta tcatctttgt aaccaccttg agcttgtagc atatttgtta attgagcaaa
    63301 ggcgctagaa gagtttgctg ggtcagcagt tgcgattttt ccttttagtt caggtttgag
    63361 aaggtcgcta tatccttcga tgttcatgcc tttagttaaa tcagggtgga cgattaaaac
    63421 actaccatct agtgtataag gagtagagaa gccagttgtg ttttgatatt ctttgataac
    63481 attatcattt tcttttgaaa tatagttttc aaagagttct ccgtgggtag catattgtgt
    63541 ataagaacca ccaaagataa catcagctac aggaacttct ttttctgact ctagtttttt
    63601 gaaaagttct ccagtaccag cttgaatcag ttctattttg ataccatatt tttcttcaaa
    63661 ggcaggaata gttgctccaa ttaagccttc tgagtttggt gaataaacga ctagcgaacc
    63721 accgtctcct ttatcagatg aactgtcatc ggcagattca ttagaagaac aagcagcata
    63781 atacatccat ttctttttca tgatggatac ctccgttgtg ttatttaagt ttattttaaa
    63841 acaatataag cgtttttaaa acctacaatt ctatcctata gtgtattgaa tctataacag
    63901 tacac
//
LOCUS       DAVLHC010000006        61032 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.006, whole genome shotgun sequence.
ACCESSION   DAVLHC010000006 DAVLHC010000000
VERSION     DAVLHC010000006.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 61032)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 61032)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..61032
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.006"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(<1..160)
                     /locus_tag="VXE25_000391"
     CDS             complement(<1..160)
                     /locus_tag="VXE25_000391"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEV0770915.1"
                     /translation="MEQLHFITKLLDIKDPNIQILDIINKDTHKEIIAKLDYEAPSCP
                     ECGSQMKKY"
     gene            363..1598
                     /gene="pspC"
                     /locus_tag="VXE25_000392"
     CDS             363..1598
                     /gene="pspC"
                     /locus_tag="VXE25_000392"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000477101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal surface protein PspC,
                     LPXTG-anchored form"
                     /protein_id="HEV0770916.1"
                     /translation="MFKSNHERRMRYSIRKFSVGVASVAVASLFMGSVVHATEKEGST
                     QAATSFNRGNGSQAEQRGELDLERDKAMKAVSEYVGKMVRDAYVKSDRKRHKNTVALV
                     NQLGNIKNRYLNEIVHSTSKSQLQELMMKSQSEVDEAVSKFEKDSFSSSSSGSSTKPE
                     TPQPENPEHQKPTTPSPDTKPSPQPEGKKPSVPDINQEKEKAKLAVVTYMSKILDDIQ
                     KHHLQKEKHRQIVALIKELDELKKQALSEIDNVNTKVEIENTVHKIFADMDAVVTKFK
                     KGLTQDTPKEPGNKKPSAPKPGMQPSPQPEVKPQPEKPKPEVKPQPEKPKPEVKPQPE
                     KPKPDNSKPQADDKKPSTTNNLSKDKQPSNQASTNEKATNKPKKSLPSTGSISNLALE
                     IAGLLTLAGATILAKKRMK"
     gene            complement(1817..2797)
                     /gene="dusB"
                     /locus_tag="VXE25_000393"
     CDS             complement(1817..2797)
                     /gene="dusB"
                     /locus_tag="VXE25_000393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006147761.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA dihydrouridine synthase DusB"
                     /protein_id="HEV0770917.1"
                     /translation="MTNLNTPFMIGNVEIPNRTVLAPMAGVTNSAFRTIAKELGAGLV
                     VMEMVSDKGIQYNNEKTLHMLHIDEGENPVSIQLFGSDEDSLARAAEFIQENTKTDIV
                     DINMGCPVNKIVKNEAGAMWLKDPDKIYSIINKVQSVLDIPLTVKMRTGWADPSLAVE
                     NALAAEAAGVSALAMHGRTREQMYTGHADLETLYKVAQALTKIPFIANGDIRTVQEAK
                     QRIEEVGADAVMIGRAAMGNPYLFNQINHYFETGEILPDLTFEDKMKIAYEHLKRLIN
                     LKGENVAVREFRGLAPHYLRGTSGAAKLRGAISQASTLAEIEALLQLEKV"
     gene            complement(2784..3656)
                     /gene="hslO"
                     /locus_tag="VXE25_000394"
     CDS             complement(2784..3656)
                     /gene="hslO"
                     /locus_tag="VXE25_000394"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000357853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Hsp33 family molecular chaperone HslO"
                     /protein_id="HEV0770918.1"
                     /translation="MDKIIKTISESGAFRAFVLDSTETVRTAQEKHQTQASSTVALGR
                     TLIASQILAANEKGNTKLTVKVLGSSSLGAIITVADTKGNVKGYVQNPGVDIKKTATG
                     EVLVGPFVGNGQFLVITDYGTGNPYNSITPLISGEIGEDLAFYLTESQQTPSAVGLNV
                     LLDEEDKVKIAGGFLVQVLPGAKKEEIARFEKRIQEMPAISTLLESDDHIEALLKAIY
                     GDEAYKRLSEEEIRFQCDCSHERFMNALASLPSSDLQEMKEEDHGVEITCQFCQTTYN
                     FDEKDLEELIRDKS"
     gene            3821..5248
                     /locus_tag="VXE25_000395"
     CDS             3821..5248
                     /locus_tag="VXE25_000395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000280545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEV0770919.1"
                     /translation="MYLGDLMEKAECGQFSILSFLLQESQTTVKAVMEETGFSKATLT
                     KYVTLLNDKALDSGLELTIHSEDENLRLSIGAATKGRDIRSLFLESAVKYQILVYLFY
                     HQQFLAHQLAQELVISEATLGRHLAGLNQILSEFDLSIQNGRWRGPEHQIRYFYFCLF
                     RKVWSSQEWEGHMQKPERKQEIANLEEICGASLSVGQKLDLVLWAHISQQRLRVNACQ
                     FQVIEEKMRGYFDNIFYLRLLRKVPSFFAGQHIPLGVEDGEMMIFFSFLLSHRILPLH
                     TMEYILGFGGQLADLLTQLIQEMKKEELLGDYTEDHVTYELSQLCAQVYLYKGYILQD
                     RYKYQLENRHPYLLMEHDFKETAEEIFHALPAFQQGTDLDKKILWEWLQLIEYMAENG
                     GQHMRIGLDLTSGFLVFSRMAAILKRYLEYNRFITIEAYDPSRHYDLLVTNNPIHKKE
                     QTPVYYLKNDLDMEDLVAIRQLLFT"
     gene            5407..6915
                     /gene="glpK"
                     /locus_tag="VXE25_000396"
     CDS             5407..6915
                     /gene="glpK"
                     /locus_tag="VXE25_000396"
                     /EC_number="2.7.1.30"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000076796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol kinase GlpK"
                     /protein_id="HEV0770920.1"
                     /translation="MSQEKYIMAIDQGTTSSRAIIFNKKGEKVSSSQKEFTQIFPQAG
                     WVEHNANEIWNSVQSVIAGAFIESGVKPNQIEAIGITNQRETTVVWDKKTGLPIYNAI
                     VWQSRQTAPLAEQLKSQGYVEKFHEKTGLIIDAYFSATKVRWILDHVEGAQERAEKGE
                     LLFGTIDTWLVWKLTDGAAHVTDYSNAARTMLYNIKELKWDDEILEILNIPKAILPEV
                     RSNSEIYGKTAPFHFYGGEVPISGMAGDQQAALFGQLAFEPGMVKNTYGTGSFIIMNT
                     GEEMQLSENNLLTTIGYGINGKVYYALEGSIFIAGSAIQWLRDGLRMVENSPESEKYA
                     RDSHNNDEVYVVPAFTGLGAPYWNQNARGSVFGLTRGTSKEDFIKATLQSIAYQVRDI
                     IDTMQVDTQTAIQVLKVDGGAAMNNFLMQFQADILGIDIARAKNLETTALGAAFLAGL
                     SVGYWKDLDELKLLNETGELFEPSMNESRKEQLYKGWKKAVKATQVFAEVDD"
     gene            6957..8783
                     /gene="glpO"
                     /locus_tag="VXE25_000397"
     CDS             6957..8783
                     /gene="glpO"
                     /locus_tag="VXE25_000397"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865074.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type 1 glycerol-3-phosphate oxidase"
                     /protein_id="HEV0770921.1"
                     /translation="MEFSKKTRELSIKKMQERTLDLLIIGGGITGAGVALQAAASGLE
                     TGLIEMQDFAEGTSSRSTKLVHGGLRYLKQFDVEVVSDTVSERAVVQQIAPHIPKSDP
                     MLLPVYDEDGATFSLFRLKVAMDLYDLLAGVSNTPTANKVLSKDQVLERQPNLKKEGL
                     VGGGVYLDFRNNDARLVIENIKRANQDGALIANHVKAEGFLFDESGKITGVVARDLLT
                     DQVFEIKARLVINTTGPWSDKVRNLSNKGTQFSQMRPTKGVHLVVDSSKIKVSQPVYF
                     DTGLGDGRMVFVLPRENKTYFGTTDTDYTGDLEHPKVTQEDVDYLLGIVNNRFPESNI
                     TIDDIESSWAGLRPLIAGNSASDYNGGNNGTISDESFDNLIATVESYLSKEKTREDVE
                     SAVSKLESSTSEKYLDPSAVSRGSSLDRDDNGLLTLAGGKITDYRKMAEGAMERVVDI
                     LKAEFDRSFKLINSKTYPVSGGELNPANVDSEIEAFAQLGVSRGLDSKEAHYLANLYG
                     SNAPKVFALAHSLEQAPGLSLADTLSLHYAMRNELALSPVDFLLRRTNHMLFMRDSLD
                     SIVEPVLDEMGRFYDWTEEEKATYRADVEAALANNDLAELKN"
     gene            8853..9557
                     /locus_tag="VXE25_000398"
     CDS             8853..9557
                     /locus_tag="VXE25_000398"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aquaporin family protein"
                     /protein_id="HEV0770922.1"
                     /translation="MMNELFGEFLGTLILILLGNGVVAGVVLPKTKSNSSGWIVITMG
                     WGIAVAVAVFVSGKLSPAHLNPAVTVGVALKGDLPWASVLPYILAQFAGAMLGQILVW
                     LQFKPHYEAEENAGNILATFSTGPAIKDTVSNLISEILGTFVLVLTIFALGLYDFQAG
                     IGTFAVGTLIVGIGLSLGGTTGYALNPARDLGPRIMHSILPIPNKGDGDWSYAWIPVV
                     GPVIGAALAVLVFSLF"
     gene            9854..10057
                     /locus_tag="VXE25_000399"
     CDS             9854..10057
                     /locus_tag="VXE25_000399"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0770923.1"
                     /translation="MPKWSNPDYVNELDPKIVDMLVEFHKSQGTLETPEAQAEIAQKR
                     EEIEQRRAELEDKKQELLNRLNK"
     gene            complement(10144..10752)
                     /locus_tag="VXE25_000400"
     CDS             complement(10144..10752)
                     /locus_tag="VXE25_000400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0770924.1"
                     /translation="MSSISPSLVVFADDSLSANSKVVSGEAQFENGSSVRFGDTQVNI
                     LSDEVLEVVNPDGSVDTIERRADGVYINGAFYMAYQKNEIDLNISFRSYDPNVWNYVN
                     TIHGNKQANTFANFMTGAGISYMIGRIGALLGGPWGAIIGGAYFGIQAYQSYLDSQSP
                     YPYYITSTYIHVAQRKWKFITEYYRNSNYTGYVKTVTTYVNF"
     gene            11894..12295
                     /locus_tag="VXE25_000401"
     CDS             11894..12295
                     /locus_tag="VXE25_000401"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009014133.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="reverse transcriptase/maturase"
                     /protein_id="HEV0770925.1"
                     /translation="MSKLLDKILSRENMLEAYNQVKSNKGSAGIDGMTIEEMDNYLRQ
                     NWRLTKELIKQRKYKPQPILKVEIPKPDGGIRQLGISTVMDRMIQQAIVQVMSPICEP
                     HFSDTSYGFRPNRSCEKAIMKLLEYLNDGYE"
     gene            12299..12610
                     /locus_tag="VXE25_000402"
     CDS             12299..12610
                     /locus_tag="VXE25_000402"
                     /inference="COORDINATES: protein motif:HMM:NF012307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0770926.1"
                     /translation="MDIDLEKFFDTVPQDRLMSLVHNIIEDGDTESLIRKYLHSGVII
                     NGQRYKTLVGTPQGGNLSPLLSNIMLNELDKELEKRGLRFVRYADDCVIRSEARQPLS
                     V"
     gene            12607..13170
                     /locus_tag="VXE25_000403"
     CDS             12607..13170
                     /locus_tag="VXE25_000403"
                     /inference="COORDINATES: protein motif:HMM:NF019984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0770927.1"
                     /translation="MMYSVSRFIEKRLGLKVNMTKTKITRPRELKYLGFGFWKSSDGW
                     KSRPHQDSVRRFKFKLKKLTQRKWSIDLTRRIEQLNLSIRGWINYFSLGNMKSIVASI
                     DERLRTRLRVIIWKQWKKKSRRLWGLLKLGVPKWIADKVSGWGDHYQLVAQKSVLKRA
                     ISKPVLEKRGLVSCLDYYLERHALKVS"
     gene            13627..14337
                     /locus_tag="VXE25_000404"
     CDS             13627..14337
                     /locus_tag="VXE25_000404"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEV0770928.1"
                     /translation="MSNSFVKLLVSQLFANLADIFFRVTIIANIYIISKSVIATSLVP
                     ILIGISSFVASLLVPLVTKRLALNRVLSLSQFGKTILLAILVGMFTVMQSVAPLVTYL
                     FVVAISILDGFAAPVSYAIVPRYATDLGKANSALSMTGEAVQLIGWGLGGLLFATIGL
                     LPTTFIILVLYIISSFLMLFLPNAEVEVLESETNLEILLKGWKLVARNPRLRLLYQQI
                     YWKFFQIRFGFLPLYLFL"
     gene            14283..14804
                     /locus_tag="VXE25_000405"
     CDS             14283..14804
                     /locus_tag="VXE25_000405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809625.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEV0770929.1"
                     /translation="MEIFSNTIWVSSIILVFVTELLNKTESYWGYSNTAYSIGIIISG
                     LIAFRLSEKFLAAKWESILFPLVAMAIVTLTILYFPNAQMFLLFSALVGMLSQLKEVP
                     ESVFLQETVEENHLVNVYSVLEVISTLAFSVFVLLMSYITESFGISISFWLSAICLMI
                     EAILIYIRRDYFK"
     gene            15118..15249
                     /locus_tag="VXE25_000406"
     CDS             15118..15249
                     /locus_tag="VXE25_000406"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000813667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="teichoic acid D-Ala incorporation-associated
                     protein DltX"
                     /protein_id="HEV0770930.1"
                     /translation="MKQRKELYLFLGRTALYFLIFLGLLYFFSYLGQGQGSFIYNEF"
     gene            15270..16820
                     /gene="dltA"
                     /locus_tag="VXE25_000407"
     CDS             15270..16820
                     /gene="dltA"
                     /locus_tag="VXE25_000407"
                     /EC_number="6.1.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012972622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--poly(phosphoribitol) ligase subunit
                     DltA"
                     /protein_id="HEV0770931.1"
                     /translation="MSNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKADSDS
                     LAAVIAQLGLPEKSPVVVFGGQEYEMLATFVALTKSGHAYIPIDSHSALERVSAILEV
                     AEPSLIIAISAFPLEQVSTPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTT
                     GKPKGVQISHDNLLSFTNWMITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGT
                     LFTLPSVITQDFKQLFAAIFSLPIAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDG
                     EELTVKTAQKLRERFPNARIINAYGPTEATVALSAVAVTDEMLATLKRLPIGYTKADS
                     PTFIIDEEGNKLPNGEQGEIIVSGPAVSKGYMKNPEKTAEAFFEFEGLPAYHTGDVGT
                     MTDEGLLLYGGRMDFQIKFNGYRIELEDVSQNLNKSRFIESAVAVPRYNKDHKVQNLL
                     AYVILKDGVREQFERDIDITKAIKEDLTDIMMSYMMPSKFLYRDSLPLTPNGKIDIKG
                     LINEVNKR"
     gene            16817..18061
                     /gene="dltB"
                     /locus_tag="VXE25_000408"
     CDS             16817..18061
                     /gene="dltB"
                     /locus_tag="VXE25_000408"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000969717.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-lipoteichoic acid biosynthesis protein
                     DltB"
                     /protein_id="HEV0770932.1"
                     /translation="MMEFFQQLPHLEPYGNPQYFVYVIAATLPIFIGLFFKKRFAWYE
                     VLVSLFFIVTMLVGGKTNQLAALGIYLCWEILLLLFYKHYRKSKDGKWVFYLVSFLSL
                     LPIIFVKVQPAINGTQSLLGFLGISYLTFRSVGIIIELRDGVIKDFTLWEFLRFLLFM
                     PTFSSGPIDRFKRFNENYQAIPERDELMDMLDESVRYIMRGFLYKFILAHVLGETLLP
                     PLKNLALQSGGFFNLYALAVMYTFGLELFFDFAGYSMFALAISNLMGIRSPINFNKPF
                     LSRDLKEFWNRWHMSLSFWFRDFVFMRMVMVLTRKKVFKNRNVTSSMAYIVNMLIMGF
                     WHGVTWYYIAYGLFHGLGLVINDAWVRKKKTLNKERKKAGKAALPENRWIQLLGMVVT
                     FHVVMLSFLIFSGFLNNLWFKK"
     gene            18075..18314
                     /gene="dltC"
                     /locus_tag="VXE25_000409"
     CDS             18075..18314
                     /gene="dltC"
                     /locus_tag="VXE25_000409"
                     /EC_number="6.1.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005591431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--poly(phosphoribitol) ligase subunit
                     DltC"
                     /protein_id="HEV0770933.1"
                     /translation="MDIKSEVIEIIDELFMEDVSDMMDEDLFDAGVLDSMGTVELIVE
                     IENRFDIRVPVTEFGRDDWNTANKIIAGIVELQNA"
     gene            18307..19575
                     /gene="dltD"
                     /locus_tag="VXE25_000410"
     CDS             18307..19575
                     /gene="dltD"
                     /locus_tag="VXE25_000410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000919885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-lipoteichoic acid biosynthesis protein
                     DltD"
                     /protein_id="HEV0770934.1"
                     /translation="MLKRLWMIFGPVLIAGLLVFLLIFFYPTEMHHNLGAEKRSAVAT
                     TIDSFKERSQKVRALSDPNVRFVPFFGSSEWLRFDGAHPAVLAEKYNRSYRPYLLGQG
                     GAASLNQYFGMQQMLPQLENKQVVYVISPQWFSKNGYDPAAFQQYFNGDQLTSFLKHQ
                     SGDQASQYAATRLLQQFPNVAMKDLVQKLASKEELSTADNEMIELLARFNERQASFFG
                     QFSVRGYVNYDKHVAKYLKILPDQFSYQAIEDVVKADAEKNTSNNEMGMENYFYNEQI
                     KKDLKKLKDSQKSFTYLKSPEYNDLQLVLTQFSKSKVNPIFIIPPVNKKWMDYAGLRE
                     DMYQQTVQKIRYQLESQGFTNIADFSKDGGEPFFMKDTIHLGWLGWLAFDKAVDPFLS
                     NPTPAPTYHLNERFFSKDWATYDGDVKEFQ"
     gene            19730..20170
                     /gene="adcR"
                     /locus_tag="VXE25_000411"
     CDS             19730..20170
                     /gene="adcR"
                     /locus_tag="VXE25_000411"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001249319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-dependent transcriptional regulator AdcR"
                     /protein_id="HEV0770935.1"
                     /translation="MRQLAKDINAFLNEVILQAENQHEILIGHCTSEVALTNTQEHIL
                     MLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDSKDARVIFYQLTDLAR
                     PIAEEHHHHHEHTLLTYEQVATQFTPNEQKVIQRFLTALVGEIK"
     gene            20170..20874
                     /locus_tag="VXE25_000412"
     CDS             20170..20874
                     /locus_tag="VXE25_000412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001269494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter ATP-binding protein"
                     /protein_id="HEV0770936.1"
                     /translation="MRYITVEDLSFYYDKEPVLEHINYSVDSGEFVTLTGENGAAKTT
                     LIKASLGILQPRIGKVAISKTNTQGKKLRIAYLPQQIASFNAGFPSTVYEFVKSGRYP
                     RKGWFRRLNAHDEEHIKASLDSVGMWEHRDKRLGSLSGGQKQRAVIARMFASDPDVFI
                     LDEPTTGMDAGSKNEFYELMHHSAHHHGKAVLMITHDPEEVKDYADRNIHLVRNQDSP
                     WRCFNVHENGQEVGHA"
     gene            20867..21673
                     /locus_tag="VXE25_000413"
     CDS             20867..21673
                     /locus_tag="VXE25_000413"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter permease"
                     /protein_id="HEV0770937.1"
                     /translation="MLSLLSYDFIQRAFLAVIAMSLFSPVLGTFLILRRQSLMSDTLS
                     HVSLSGVAFGLVLGISPTVSTIAIVLIAAVFLEYLRTVYKSFMEIGTAILMSTGLAVS
                     LIVMSKGRSSSSMSLDQYLFGSIVTISEEQVISLFVIAAVVLILTFLFLRPMYILTFD
                     EDTAFVDGLPVRTMSILFNMVTGVAIALMIPAAGALLVSTIMVLPASIALRLGKNFKS
                     VMLLASAIGFLGMVAGLYISYYAETPASASITIIFVTVFILISLVRRFIK"
     gene            21683..23188
                     /gene="adcA"
                     /locus_tag="VXE25_000414"
     CDS             21683..23188
                     /gene="adcA"
                     /locus_tag="VXE25_000414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000724057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ABC transporter substrate-binding
                     lipoprotein AdcA"
                     /protein_id="HEV0770938.1"
                     /translation="MKKISLLLASLCALFLVACSNQKQADGKLNIVTTFYPVYEFTKQ
                     VAGDTANVELLIGAGTEPHEYEPSAKAVAKIQDADTFVYENENMETWVPKLLDTLDKK
                     KVKTIKATGDMLLLPGGEEEEGDHDHGEEGHHHEFDPHVWLSPVRAIKLVEHIRDSLS
                     ADYPDKKETFEKNAAAYIEKLQALDKAYAEGLSQAKQKSFVTQHAAFNYLALDYGLKQ
                     VAISGLSPDAEPSAARLAELTEYVKKNKIAYIYFEENASQALANTLSKEAGVKTDVLN
                     PLESLTEEDTKAGENYISVMEKNLKALKQTTDQEGPAIEPEKAEDTKTVPNGYFEDAA
                     VKDRTLSDYAGNWQSVYPFLEDGTFDQVFDYKAKLTGKMTQAEYKAYYTKGYQTDVTK
                     INITDNTMEFVQGGQSKKYTYKYVGKKILTYKKGNRGVRFLFEATDADAGQFKYVQFS
                     DHNVAPVKAEHFHIFFGGTSQEALFEEMDNWPTYYPDNLSGQEIAQEMLAH"
     gene            complement(24010..24783)
                     /locus_tag="VXE25_000415"
     CDS             complement(24010..24783)
                     /locus_tag="VXE25_000415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000588554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HEV0770939.1"
                     /translation="MIKDERVLELIEIIKKKKRIAVKELAEITFSSTSTLRRDLIFLE
                     NQGLIKRKHGYVTLSSMNTIELSHQIREGESTRQKRLIASLAKDFIRSGMCIYLDSST
                     TVYELCPYLSELDNLIIFTNGLHTAQTLSETVKDSSKIFITSGEVKHQSCSVVNYDKE
                     NSLLDHFNIDLAFCSARGIDDQYVYEASLSQAISKKNTIDKAHETILLIDSSKFYKTG
                     FFKINPLSKYTTFISDTVPDQKLLDAVELFDGEWVSDIQ"
     gene            24959..26362
                     /locus_tag="VXE25_000416"
     CDS             24959..26362
                     /locus_tag="VXE25_000416"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000388528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhamnulokinase"
                     /protein_id="HEV0770940.1"
                     /translation="MEAVLAIDLGATSGRAIVGYLSENKLVMEEINRFSNLPIRVKGH
                     LSWDIDFLLAKILESIRLANTSYKILSIGIDTWGVDFGLIDNEGKLLSQPVHYRDERT
                     KGVLKEISEMTELEKLYSETGNQIMEINTLFQLFKARQESPDSFYKTNKILLMPDLFN
                     YLLTGKFATEKSIASTTQLFDPRSQNWNQNILKLFELDSSLLPEIVSEGNVLGRIKKE
                     YGLGDIPVVNVCSHDTASAIVSVPKTEGSLFISSGTWSLVGVELTSPILTTESFSYGF
                     TNEVGKDGVITFLKNCTGLWIIEELRRSFERRGKAYSFDDIRTMVEKEKENLPLIDTE
                     STEFATESDMHKTLTEYLAYHHETREWTDGQLFKIVYESLAETYRKAIELLEELTHKV
                     YKRIYVIGGGARASYFNQMIADRTGKEVLTGLTEATAVGNIVVQLIAMGQLKGMEEAH
                     HVIEEFLQLESYYSQKN"
     gene            26477..27115
                     /locus_tag="VXE25_000417"
     CDS             26477..27115
                     /locus_tag="VXE25_000417"
                     /EC_number="4.1.2.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001286141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-fuculose-phosphate aldolase"
                     /protein_id="HEV0770941.1"
                     /translation="MSDVKQELIKYGKKLVETDLTKGTGGNLSVFDREKQLMAITPSG
                     IDFFEIKESDIVVMDINGNVVEGERLPSSEWYMHLIQYQTRDDIDAIIHAHTTYATVL
                     ACLREPLPASHYMIAVAGKDVRVAEYATYGTKELAVNAAKAMEGRRAVLLANHGILAG
                     AQNLLNAFNIVEEVEYCAKIYCLAKNFGEPVVLPDEEMELMAEKFKTYGQRK"
     gene            27127..27567
                     /locus_tag="VXE25_000418"
     CDS             27127..27567
                     /locus_tag="VXE25_000418"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000912112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RbsD/FucU family protein"
                     /protein_id="HEV0770942.1"
                     /translation="MLKHIPKNISPDLLKTLMEMGHGDEIVLADANYPSASCANKLIR
                     CDGVNIPELLDSILYLMPLDSYVDSSIQFMNVVSGDDIPKIWGTYRQMIEGHGTDLKT
                     ITYLRREDFYERSKKAYAIVATGETSLYANIILKKGVVVERENV"
     gene            27560..27991
                     /locus_tag="VXE25_000419"
     CDS             27560..27991
                     /locus_tag="VXE25_000419"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000483177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEV0770943.1"
                     /translation="MFNRGILVASHGDFASGALMTAEMFVGETTNDRVRTLGLMPGEN
                     IVEFEHYFKNQVDELLDSNQEVIVLTDLIGGSPNNVALSRFLNLDSVDIVTGFNIPLL
                     VELISNYDSKINLEEIVHNAQNSLFNVKQQLNVEEEEDLCL"
     gene            27982..28452
                     /locus_tag="VXE25_000420"
     CDS             27982..28452
                     /locus_tag="VXE25_000420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000020992.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEV0770944.1"
                     /translation="MSIEFVRIDDRLVHGQVVTTWLKKYDIEQVIIVNDRISEDKTRQ
                     SILKISAPVGLKIVFFSVKRFVEVLNSVPIKKRTMLIYTNPKDVYDSIEGNLKLEYLN
                     VGQMSKTEENEKVTGGVALGEEDKYYFKKIVDKGTRVEIQMVPNDKVTMLEKFL"
     gene            28477..29250
                     /locus_tag="VXE25_000421"
     CDS             28477..29250
                     /locus_tag="VXE25_000421"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000899624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS
                     mannose/fructose/sorbose/N-acetylgalactosamine transporter
                     subunit IIC"
                     /protein_id="HEV0770945.1"
                     /translation="MLFTQALLVTLVGIIATIDYNGPLFMIHRPLVTSAMVGLVLGDF
                     TQGVLIGSALELTWLGVTGIGGYTPPDTISGAIIGTAFGILSGQGETAGIAIAVPIAV
                     ATQQLDVLAKTLDVYFVKKADNDAKNGDYSKIGFYHYSSLVLITLFKIVPIFLAIMLG
                     GEYVADLFAKVPPIVMQGLNSAGALLPSIGFGMLLNMMLKKNMWVFLLIGFICSVYGG
                     MSTIGISLVGIAVAYFYDMIGSKPQETTSSSDVEEDLDL"
     gene            29247..30047
                     /locus_tag="VXE25_000422"
     CDS             29247..30047
                     /locus_tag="VXE25_000422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002935197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose/fructose/sorbose transporter family
                     subunit IID"
                     /protein_id="HEV0770946.1"
                     /translation="MMNNKVTKVELKKVFKRSFMYGSSWNYERMQNLGFLYTILPVLK
                     KLYPDKDSASPAMKRHLEFFNTHQTAAPFILGVTSAMEEQEGNEGAASITGIKVGLMG
                     PLAGLGDSLFWLTLVPICFSIGASYSKDGGALGIFIALILFNIINIPVKYFGLKYGYT
                     KGSSLIQENNTKGTLNRVTSMATALGLVLVGGLIPSMVGINFGLEFKQGELVISVQEM
                     ITKLIPGFIPMALTLLMCKLIRKGKNPVVLIFSVMAIGVILVVLGILK"
     gene            30106..32400
                     /locus_tag="VXE25_000423"
     CDS             30106..32400
                     /locus_tag="VXE25_000423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000780629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 95 protein"
                     /protein_id="HEV0770947.1"
                     /translation="MKLWYKKAASNWNEALPIGNGHLGGMIYGSATKECIQLNDETIW
                     YRGKSDRNNPDSLLHLKKIREYLLDGEIQKAEELIKLTMFATPRDQSHYELLGELYIE
                     HIDIQSCALSLYERELDLDTAISNVVFEPNSCNLQIKREYFTSFNKNILCCRIVSSVQ
                     NTLNLNINLGRNKRFNDEVSKLDSSTILMSASAGGRKGVQFKVVCHSKVTDGEVSVLG
                     ETIVIRNATEVFLYLKSMTDYWGNIDISSLQGEFSSIDYFTEKDEHVKKYQEQFNRVD
                     FKLDYSKDCLSIPTNLLLENTKKYSNYLTNLLFHYGRYLLISSSQPNGLPANLQGIWC
                     DELNPIWGSKYTININTQMNYWMVGPCDLPEVEYPLFDMLERMREPGRLTAKKMYGAR
                     GFTAHHNTDGFGDTAPQSHAMGAAIWVLTIPWLCTHIWEHYLYFQDERILTEHFEMIK
                     EAFLFFEDYLFEVDGYLMTGPSVSPENKYRLKNGIEGNACLSSTIDNQILRYFCDSCI
                     GIAKQLGDNSDFISRVKELKKKLPKTKIGSNGQIQEWLEDYEEVEPGHRHISPLFGLY
                     PYNEIDIHKTPELAEAAKITINRRLSNANFLSSQEREQAINNWLVSGLHASTQTGWSA
                     AWLIHFFARLYQGEPAYNQINGLLNNATLGNLFLDHPPFQIDGNLGLVSGICELLVQS
                     HHNWLSLIPALPSAWSEGEVKGFRVRGGYKVSFAWKNGDITFLKLEGGNKDQKVRVRI
                     YGKNTDVQNIELVFNSEKIIELNF"
     gene            32410..35526
                     /locus_tag="VXE25_000424"
     CDS             32410..35526
                     /locus_tag="VXE25_000424"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001031112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="discoidin domain-containing protein"
                     /protein_id="HEV0770948.1"
                     /translation="MNKEKIKRKLITILFVCIGMLCFGLLAGVKADNRVQMRTTINNE
                     SPLLLSPLYGNDNGNGLWWGNTLKGAWEAIPEDVKPYAAIELHPAKVCKPTSCIPRDT
                     KELREWYVKMLEEAQSLNIPVFLVIMSAGERNTVPPEWLDEQFQKYSVLKGVLNIENY
                     WIYNNQLAPHSAKYLEVCAKYGAHFIWHDHEKWFWETIMNDPTFFEASQKYHKNLVLA
                     TKNTPIRDDAGTDSIVSGFWLSGLCDNWGSSTDTWKWWEKHYTNTFETGRARDMRSYA
                     SEPESMIAMEMMNVYTGGGTVYNFECAAYTFMTNDVPTPAFTKGIIPFFRHAIQNPAP
                     SKEEVVNRTKAVFWNGEGRISSLNGFYQGLYSNDETMPLYNNGRYHILPVIHEKIDKE
                     KISSIFPNAKILTKNSEELSSKVNYLNSLYPKLYEGDGYAQRVGNSWYIYNSNANINK
                     NQQVMLPMYTNNTKSLSLDLTPHTYAVVKENPNNLHILLNNYRTDKTAMWALSGNFDA
                     SKSWKKEELELANWISKNYSINPVDNDFRTTTLTLKGHTGHKPQINISGDKNHYTYTE
                     NWDENTHVYTITVNHNGMVEMSINTEGTGPVPFPTPDKFNDGNLNIAYAKPTTQSSVD
                     YNGDPNRAVDGNRNGNFNSGSVTHTRADNPSWWEVDLKKMDKVGLVKIYNRTDAETQR
                     LSNFDVILYDNNRNEVAKKHVNNLSGESVSLDFKEKGARYIKVKLLTSGVPLSLAEVE
                     VFRESDGKQSEEDIDKITEDKVVSTNKVATQSSTNYEGVAALAVDGNKDGDYGHHSVT
                     HTKADSNAWWQVDLGEEFTVSKVDIYNRTDAEPQRLSNFDVIFLSSSGEEVFRRHFDK
                     VVDGLLSLKVPSVGAKLVKIELKSAAIPLSLAEVEVYGSKRTPKKLSNIALTKETRQS
                     STDYNGFSRLAVDGNKNGDYGHHSVTHTKGDSPSWWEIDLAQTEELEKLIIYNRTDAE
                     IQRLSNFDIIIYDSNNHEVFKQHIDSLESNNLSIDLKGLKGKKVRISLRNAGIPLSLA
                     EVEVYTYK"
     gene            35583..37349
                     /locus_tag="VXE25_000425"
     CDS             35583..37349
                     /locus_tag="VXE25_000425"
                     /EC_number="5.3.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002935191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-fucose isomerase"
                     /protein_id="HEV0770949.1"
                     /translation="MIQHPRIGIRPTIDGRRQGVRESLEVQTMNMAKSVADLISSTLK
                     YPDGEPVECVISPSTIGRVPEAAASHELFKKSNVCATITVTPCWCYGSETMDMSPDIP
                     HAIWGFNGTERPGAVYLAAVLASHAQKGIPAFGIYGRDVQEANDTDIPEDVKEKLLRY
                     ARAALATGLMRDTAYLSMGSVSMGIGGSIVNPDFFQEYLGMRNESVDMTEFTRRMDRG
                     IYDPEEFERALKWVKENVKEGFDHNREDLVLSREEKDRQWEFVIKMFMIGRDLMVGNP
                     RLAELGFEEEAVGHHALVAGFQGQRQWTDHFPNGDFMETFLNTQFDWNGIRKPFVFAT
                     ENDSLNGVSMLFNYLLTNTPQIFADVRTYWSPEAVKRVTGHTLEGRAAAGFLHLINSG
                     SCTLDGTGQATRDGKPVMKPFWELEESEVQAMLENTDFPPANREYFRGGGFSTRFLTK
                     GDMPVTMVRLNLLKGVGPVLQIAEGYTLELPEDVHHTLDNRTDPGWPTTWFAPRLTGK
                     GAFKSVYDVMNNWGANHGAITYGHIGADLITLASMLRIPVNMHNVPEEDIFRPKNWSL
                     FGTEDLESADYRACQLLGPLHK"
     gene            37495..38646
                     /locus_tag="VXE25_000426"
     CDS             37495..38646
                     /locus_tag="VXE25_000426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862055.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-containing alcohol dehydrogenase"
                     /protein_id="HEV0770950.1"
                     /translation="MATFYVPAVNLIGKGVVNEVGPYIKELGYKKALLVTDKYIEGSD
                     ILPKVLKPLDTEGIEYVIFSDVEPNPTCKNVTDGVAALQEHGCDFIISLGGGSPQDAA
                     SCISIMATNGGKPQDYEGLHKSAKKGLPVVAINTTAGTSAEITINYVITDEERKVKMV
                     MVDKNSLALISVNDPELMLSKPKGLTAATGMDALTHAVEALVTPGAYDVTKKLSIGAI
                     ELIKEYLPRAVENGHDIEAREGMVNAIFLGGMSFNNAGLGYVHSMAHQLGAVYNLPHG
                     VCCAMLLPVIERENAKRVPEAFRNVAKALGLHVEGKSDQECADYAIVEIEKLSETVGI
                     PKKLTELGIEEKDFDFEYLSKNALIDACAPGNPFMPTLEETIAFYKELF"
     gene            38791..39675
                     /locus_tag="VXE25_000427"
     CDS             38791..39675
                     /locus_tag="VXE25_000427"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001838996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPFH domain-containing protein"
                     /protein_id="HEV0770951.1"
                     /translation="MIFLIVCVLLLVIVTLSTVYVVRQQSVAIIERFGKYQKVANSGI
                     HIRLPFGIDSIAARIQLRLLQSDIVVETKTKDNVFVMMNVATQYRVNEQSVTDAYYKL
                     IRPESQIKSYIEDALRSSVPKLTLDELFEKKDEIALEVQHQVAEEMTTYGYIIVKTLI
                     TKVEPDAEVKQSMNEINAAQRKRVAAQELAEADKIKIVTAAEAEAEKDRLHGVGIAQQ
                     RKAIVDGLAESITELKEANVGMTEEQIMSILLTNQYLDTLNTFASKGNQTIFLPNTPN
                     GVDDIRTQILSALRAEKK"
     gene            40074..40325
                     /locus_tag="VXE25_000428"
     CDS             40074..40325
                     /locus_tag="VXE25_000428"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000657761.1"
                     /note="The YSIRK form of extended signal peptide directs
                     nascent proteins to the cross-wall site, while signal
                     peptides lacking YSIRK direct proteins instead to the cell
                     pole. A large fraction of YSIRK proteins are surface
                     proteins anchored by sortase-mediated processing of a
                     C-terminal LPXTG motif; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YSIRK-type signal peptide-containing protein"
                     /protein_id="HEV0770952.1"
                     /translation="MKEFQFERKQRFSLRKYAIGACSVLLGTSLFFAGMGAQPVQATE
                     TSSALISSHYLDEQDLSEKLKSELQWLELENKLLNLWEH"
     gene            40313..40600
                     /locus_tag="VXE25_000429"
                     /pseudo
     CDS             40313..40600
                     /locus_tag="VXE25_000429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000501069.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(40783..40910)
                     /locus_tag="VXE25_000430"
                     /pseudo
     CDS             complement(40783..40910)
                     /locus_tag="VXE25_000430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001836165.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="fucose isomerase"
     gene            complement(41005..42336)
                     /locus_tag="VXE25_000431"
     CDS             complement(41005..42336)
                     /locus_tag="VXE25_000431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000686986.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptidase"
                     /protein_id="HEV0770953.1"
                     /translation="MKIDITNQVKDEFLISLKTLISYPSVLNEGENGTPFGQAIQDVL
                     EKTLEICRDIGFTTYLDPKGYYGYAEIGQGAELLAILCHLDVVPSGDEADWQTPPFEA
                     TIKDGWVFGRGVQDDKGPSLAALYAVKSLLDQGIQFKKRVRFIFGTDEETLWRCMARY
                     NTIEEQASMGFAPDSSFPLTYAEKGLLQVKLHGPGSDQLELEVGGAFNVVPGKANYQG
                     PLYEQVCNDLKEAGYDYQSTEQTVTVLGVPKHAKDASQGINAVIRLATILAPLQEHPA
                     LSFLATQAGQDGTGRQIFGDIADEPSGHLSFNVAGLMINHERSEIRIDIRTPVLADKE
                     ELVELLTRCAQNYQLRYEEFDYLAPLYVAKDSKLVSTLMQIYQEKTGDNSPAISSGGA
                     TFARTMPNCVAFGALFPGAKQTEHQANECAVLEDLYRAMDIYAEAVYRLAT"
     gene            complement(42358..43869)
                     /locus_tag="VXE25_000432"
     CDS             complement(42358..43869)
                     /locus_tag="VXE25_000432"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004191872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YfcC family protein"
                     /protein_id="HEV0770954.1"
                     /translation="MSEKAKKGFKMPSSYTVLLIIIAIMAVLTWFIPAGAFIEGIYET
                     QPQNPQGIWDVLMAPIRAMLGTHPEEGSLIKETSAAIDVAFFILMVGGFLGIVNKTGA
                     LDVGIASIVKKYKGREKMLILVLMPLFALGGTTYGMGEETMAFYPLLVPVMMAVGFDS
                     LTGVAIILLGSQIGCLASTLNPFATGIASATAGVGTGDGIVLRLIFWVTLTALSTWFV
                     YRYADKIQKDPTKSLVYSTRKEDLKHFNVEESSSVESTLSSKQKSVLFLFVLTFILMV
                     LSFIPWTDLGVTIFDDFNAWLTGLPVIGNIVGSSTSALGTWYFPEGAMLFAFMGILIG
                     VIYGLKEDKIISSFMNGAADLLSVALIVAIARGIQVIMNDGMITDTILNWGKEGLSGL
                     SSQVFIVVTYIFYLPMSFLIPSSSGLASATMGIMAPLGEFVNVRPSLIITAYQSASGV
                     LNLIAPTSGIVMGALALGRINIGTWWKFMGKLVVAIIVVTIALLLLGTFLPFL"
     gene            complement(44078..45025)
                     /gene="arcC"
                     /locus_tag="VXE25_000433"
     CDS             complement(44078..45025)
                     /gene="arcC"
                     /locus_tag="VXE25_000433"
                     /EC_number="2.7.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003025409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbamate kinase"
                     /protein_id="HEV0770955.1"
                     /translation="MANRKIVVALGGNAILSSDPSAKAQQEALVETAKHLVKLIKNGD
                     DLIITHGNGPQVGNLLLQHLASDSEKNPAFPLDSLVAMTEGSIGFWLKNALQNALLDE
                     GIEKNVASVVTQVVVDKNDPAFVNLSKPIGPFYSEEEAKAEAEKSGATFKEDAGRGWR
                     KVVASPKPVDIKEIETIRTLLNNGQVVVAAGGGGIPVVKENNGHLTGVEAVIDKDFAS
                     QRLAELVDADLFIVLTGVDYVFVNYNKPNQEKLEHVNVAQLEEYIKQDQFAPGSMLPK
                     VEAAIAFVNGRPEGKAVITSLENLGALIESESGTIIEKG"
     gene            complement(45190..46206)
                     /gene="argF"
                     /locus_tag="VXE25_000434"
     CDS             complement(45190..46206)
                     /gene="argF"
                     /locus_tag="VXE25_000434"
                     /EC_number="2.1.3.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003073325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ornithine carbamoyltransferase"
                     /protein_id="HEV0770956.1"
                     /translation="MTNSVFQGRSFLAEKDFTRAELEYLIGLSAHLKDLKKRNIQHHY
                     LAGKNIALLFEKTSTRTRAAFTTAAIDLGAHPEYLGANDIQLGKKESTEDTAKVLGRM
                     FDGIEFRGFSQRMVEELAEFSGVPVWNGLTDEWHPTQMLADYLTVQENFGRLEGLTLV
                     YCGDGRNNVANSLLVTGAILGVNVHIFSPKELFPEKEIVELAEGFAKESGAHVLITED
                     ADEAVKDADVLYTDVWVSMGEEDKFAERVALLKPYQVNMDLVKKAGNENLIFLHCLPA
                     FHDTHTVYGKDVAEKFGVEEMEVTDEVFRSKYARHFDQAENRMHTIKAVMAATLGNLY
                     IPKV"
     gene            complement(46264..47493)
                     /gene="arcA"
                     /locus_tag="VXE25_000435"
     CDS             complement(46264..47493)
                     /gene="arcA"
                     /locus_tag="VXE25_000435"
                     /EC_number="3.5.3.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000094613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine deiminase"
                     /protein_id="HEV0770957.1"
                     /translation="MSSHPIQVFSEIGKLKKVMLHRPGKELENLLPDYLERLLFDDIP
                     FLEDAQKEHDAFAQALRDEGIEVLYLEQLAAESLTSPEIRDQFIEEYLDEANIRDRQT
                     KVAIRELLHGIKDNQELVEKTMAGIQKVELPEIPDESKDLTDLVESDYPFAIDPMPNL
                     YFTRDPFATIGNAVSLNHMFADTRNRETLYGKYIFKYHPIYGGKVDLVYNREEDTRIE
                     GGDELVLSKDVLAVGISQRTDAASIEKLLVNIFKKNVGFKKVLAFEFANNRKFMHLDT
                     VFTMVDYDKFTIHPEIEGDLHVYSVTYENEKLKIVEEKGDLAELLAQNLGVEKVHLIR
                     CGGGNIVAAAREQWNDGSNTLTIAPGVVVVYDRNTVTNKILEEYGLRLIKIRGSELVR
                     GRGGPRCMSMPFEREEV"
     gene            48248..49927
                     /locus_tag="VXE25_000436"
     CDS             48248..49927
                     /locus_tag="VXE25_000436"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000721501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-L-fucosidase"
                     /protein_id="HEV0770958.1"
                     /translation="MKKIKPHGPLPSQTQLAYLGDELAAFIHFGPNTFYDQEWGTGQE
                     DPERFNPSQLDAREWVRVLKETGFKKLILVVKHHDGFVLYPTAHTDYSVKVSPWRRGK
                     GDLLLEVSQAATEFDMDMGVYLSPWDAHSPLYHVDREADYNAYYLAQLKEILSNPNYG
                     NAGKFAEVWMDGARGEGAQKVNYEFEKWFETIRDLQGDCLIFSTEGTSIRWIGNERGY
                     AGDPLWQKVNPDKLGTEAELNYLQHGDPSGTIFSIGEADVSIRPGWFYHEDQDPKSLE
                     ELVEIYFHSVGRGTPLLLNIPPNQAGLFDAKDIERLYEFATYRNELYKEDLALGAEVS
                     GPALSADFACRHLTDGLETSSWANDADLPIQLELDLGSPKTFDVIELREDLKLGQRIS
                     AFHVQVEVDGVWQEFGRGFTVGHKRLLRGSLVEAQKVRVMITEAQSIPVLTKISLYKT
                     PGLSKKEVVQELAFAEKSLAVAKGENAYFTVKRRECSGPLEAKISIQPGTGVHGVAYQ
                     DEIYVLQFQAGESKKDLHLPTLYFAGDKTLDFYLNLTVDGQLVDQLQVQVS"
     gene            complement(49967..52051)
                     /locus_tag="VXE25_000437"
     CDS             complement(49967..52051)
                     /locus_tag="VXE25_000437"
                     /EC_number="3.2.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000803403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GH92 family glycosyl hydrolase"
                     /protein_id="HEV0770959.1"
                     /translation="MKPLLETIDTRFGTASKHAFSRGNTLPYTGVPFGMNYFVPQTSD
                     QDGSWFFDPHLPIFQGIRLTHQPSPWIGDYSWLLLTPVTSQLGGDSLFHRQSSYDIDK
                     ACFQPHYLKLFSLRYQIETQLTPTCYGASIRLNQKQGKALSLYLHAADELTVEQVDKR
                     TLALRQEGKTETNKNSLTMFTALQMNTDILAISQEAGDWRIDLASSQTEMQLATSFIS
                     PSQALINLPQEDFDSCKTSAQADWENLLHRFDIIETGEADRTFFDHCLYRLFLFPQTF
                     YEVDESGKAIHMDLATGTVKPGVLFSNNGFWDTFRTTFPLFALIIPEHYQRFLEGFLN
                     SYRDTGFLPKWLAPDERGMMPGTLLDGIIADSACKDMAPDLEGELFQAMLETASKADP
                     LGINGRHGLAQYQELGYLSTDHHESVSHTLDYAYSDFCIASCAKKLENIEIAETYKAA
                     SQNYRQLFDAETGYMRARDNQGNFHPDFSPYSWGRDYAECSAIQATLGVLHDIPGLIQ
                     LMGGKETFSNYLLKACQDAPLFETTGYGYEIHEMSEMATAPFGQIAISNQPSFHIPYL
                     FRYSDYPDYTALLIKTLRQKAFHPSWEAYPGDEDNGSLSAWYIWSALGFYPTCPGKPS
                     YDLGIPLFDHLRVYLAKEDKWLDIHTKQNHNHFNFVKECRLNKTLVSTIQHQDLLKAE
                     QLTFTLSWLPSH"
     gene            52222..53502
                     /locus_tag="VXE25_000438"
     CDS             52222..53502
                     /locus_tag="VXE25_000438"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844830.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 125 protein"
                     /protein_id="HEV0770960.1"
                     /translation="MIYSKEIVREWLDEVAERAKDHPEWVDVFERCYTDTLDNTVEIL
                     EDGSTFVLTGDIPAMWLRDSTAQLRPYLHVAKRDSLLRQTIAGLVKRQMTLVLKDPYA
                     NSFNIEENWKGHHETDHTDLNGWIWERKYEVDSLCYPLQLAYLLWKETGETSQFDEIF
                     VAATKEILHLWTVEQDHKNSPYRFVRDTDRKEDTLVNDGFGPDFAVTGMTWSAFRPSD
                     DCCQYSYLIPSNMFAVVVLGYVQEIFAALNLADSQSVIADAKRLQDEIQEGIENYAYT
                     TNSKGEKIYAFEVDGLGNASIMDDPNVPSLLAAPYLGYCSVDDEVYQATRRTILSSEN
                     PYFYQGEYASGLGSSHTFYRYIWPIALSIQGLTTRDKAEKKFLLDQLVACDGGTGVMH
                     ESFHVDDPTLYSREWFSWANMMFCELVLDYLDIR"
     gene            53593..56238
                     /locus_tag="VXE25_000439"
     CDS             53593..56238
                     /locus_tag="VXE25_000439"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000432759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-mannosidase"
                     /protein_id="HEV0770961.1"
                     /translation="MENVVVHIISHSHWDREWYLPFESHRMQLVELFDNLFELFENDP
                     EFKSFHLDGQTIVLDDYLQIRPENRDKVQRYIDEGKLKIGPFYILQDDYLISSEANVR
                     NTLIGQQEAAKWGKSTQIGYFPDTFGNMGQAPQILQKSGIHVAAFGRGVKPIGFDNQV
                     LEDEQFTSQFSEMYWQGVDGSRVLGILFANWYSNGNEIPVDKDEALTFWKQKLSDVRA
                     YASTNQWLMMNGCDHQPVQKNLSEAIRVANELFPDVIFVHSSFDEYVQAVEGALPEHL
                     STVTGELTSQETDGWYTLANTSSSRIYLKQAFQENSNLLEQVVEPLTIITGGHNHKDQ
                     LTYAWKTLLQNAPHDSICGCSVDEVHREMETRFAKVNQVGNFVKSNLLNEWKGKIATD
                     KAQSDYLFTVINTGLHDKVDTVSTVIDVATCDFKELHPTEGYKKMAALILPSYRVEDL
                     DGRPVEATIEDLGANFEYDLPKDKFRQARIARQVRVTIPVQLAPLSWTTFQLLEGKQE
                     HREGIYQNGVIDTPFVTVSVDDNITVYDKTTHEAYEDFIRFEDRGDIGNEYIYFQPKG
                     TEPIFAELKGHEVLENTACYAKILLKHELTVPVSADEKLEEEQQGIIEFMKREAGRSE
                     ELTNIPLETELTVFVDNPQIRFKTRFTNTAKDHRIRLLVKTHNTRPSNDSESIYEVVT
                     RPNKPAASWENPENPQHQQAFVSLYDDEKGVTVSNKGLNEYEILGDNTIAVTILRASG
                     ELGDWGYFPTPEAQCLREFEVEFALECHQAQERFSAYRRAKALQTSFTSLQLARQEGS
                     VVAIGSLLSHSVLSIPQVCPTAFKVAENEEGYVLRYYNMSQENVRISEHQQTILDLLE
                     RPYPVHSGLLAPQEIRTEFIKKEEI"
     gene            56321..57190
                     /locus_tag="VXE25_000440"
     CDS             56321..57190
                     /locus_tag="VXE25_000440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HEV0770962.1"
                     /translation="MTIATIDIGGTGIKFASLTPDGKILDKTSIPTPKNLEDLLAWLD
                     QRLSEQDYSGIAMSVPGAVNQETGVIDGFSAVPYIHCFSWYEALSSYQLPVHLENDAN
                     CVGLSELLAHPELENAACVVIGTGIGGAMIINGRLHRGRHGLGGEFGYMTTLAPAGKL
                     NNWSQLASTGNMVRYVIEKSGHTDWDGRKIYQEAAAGNALCQEAIERMNCNLAQGLLN
                     IQYLIDPDVISLGGSISQNPDFIQGVKKAVEDFVDAYEEYTVAPVIQACTYHADANLY
                     GALVNWLQEEKQW"
     gene            57184..59064
                     /locus_tag="VXE25_000441"
     CDS             57184..59064
                     /locus_tag="VXE25_000441"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-N-acetylhexosaminidase"
                     /protein_id="HEV0770963.1"
                     /translation="MVRFTGLSPKQTQAIEVLKGHISLPDVEVAVTQSDQASISIQGE
                     EGHYQLTYRKPHQLYRALSLLVTVLAEADKVEIEEQAAYEDLAYMVDCSRNAVLNVAS
                     AKQMIEVLALMGYSTFELYMEDTYQIEGQPYFGYFRGAYSAEELQEIEAYAQQFDMTF
                     VPCIQTLAHLSAFVKWGVKEVQELRDVEDILLIGEEKVYDLIDGMFATLSKLKTRKVN
                     IGMDEAHLVGLGRYLILNGVVDRSLLMCQHLERVLDIADKYGFHCQMWSDMFFKLMSA
                     DGQYDRDVEIPEETRVYLDRLKDRVTLVYWDYYQDSEEKYNRNFRNHHKISHDLAFAG
                     GAWKWIGFTPHNHFSRLVAIEANKACRANQIKEVIVTGWGDNGGETAQFSILPSLQIW
                     AELSYRNDLDGLSAHFKTNTGLTVEDFMQIDLANLLPDLPGNLSGINPNRYVFYQDIL
                     CPILDQHMTPEQDKPHFAQAAETLANIKEKAGNYAYLFETQAQLNAILSSKVDVGRRI
                     RQAYQADDKESLQQIARQELPELRSQIEDFHALFSHQWLKENKVFGLDTVDIRMGGLL
                     QRIKRAESRIEVYLAGQLDRIDELEVEILPFTDFYADKDFAATTANQWHTIATASTIY
                     TT"
     gene            59442..59804
                     /locus_tag="VXE25_000442"
     CDS             59442..59804
                     /locus_tag="VXE25_000442"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000604884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0770964.1"
                     /translation="MPKTKTLAELADVILWSFDFANDHAHAFFMDNVEWSHADSYFLS
                     FVSDDVEERYTENVYLDSLSVKQKFKFIFDFGDEWRFECQVLREIETEDEEAYLVRSV
                     GTSPEQYPDYDGFDYEEW"
     gene            complement(59874..60263)
                     /locus_tag="VXE25_000443"
     CDS             complement(59874..60263)
                     /locus_tag="VXE25_000443"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="IS5 family transposase"
                     /protein_id="HEV0770965.1"
                     /translation="MKAQAIVTSQGRIVSLDITVNYCHDMKLFKMSCRNIGQAGKILA
                     DSGYQGPMKIYPQAQTPRKSSKLKPLTAEDKACNHALSKERSKVENIFAKVETFKMFS
                     TTYRNHRKRFGLRMNLIAGIINHELGF"
     gene            complement(60280..60588)
                     /locus_tag="VXE25_000444"
     CDS             complement(60280..60588)
                     /locus_tag="VXE25_000444"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
                     /protein_id="HEV0770966.1"
                     /translation="MLKTAYQLKHAKGGRKPKLSLEDLLMATLQYVREYRTYEEIATD
                     FGIHESNLIRRSQWVEVTLVQSGVTISRTPLSSEDTVMIDATEVKINRPKKTISESFW
                     "
     gene            complement(60679..60857)
                     /locus_tag="VXE25_000445"
                     /pseudo
     CDS             complement(60679..60857)
                     /locus_tag="VXE25_000445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812165.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
BASE COUNT        18501 a        11179 c        13348 g        18004 t
ORIGIN      
        1 aatatttctt catttgactt ccgcactcag gacaagatgg agcttcatag tccagtttgg
       61 cgatgatttc cttgtgtgta tccttattga tgatgtctaa aatctggata ttagggtctt
      121 taatgtctag taattttgtg ataaaatgta attgttccat atgattcttt ctaatgagtt
      181 gttttgtcgc ttttcattat aggtcatatg ggactttttt tctacacaaa ataggctcca
      241 taatatccat aggggattta cccactacaa atattataga gccaaataat gtagcaaatt
      301 tcatatacaa ttcatattag caggatatac tgtagttaat taaaattatg gagaatatag
      361 acatgtttaa atcaaatcat gagcgaagaa tgcgttattc cattcgtaaa tttagtgtag
      421 gagtagctag cgtagctgtt gccagtcttt ttatgggaag tgttgtacat gcgacagaga
      481 aagagggaag tacccaagca gccacttctt ttaatagggg aaatggaagt caggcagaac
      541 aacgtggaga actcgattta gaacgagata aggcaatgaa agcggtcagt gaatatgtag
      601 gaaaaatggt gagagatgcc tatgtaaaat cagatagaaa acgacataaa aatactgtag
      661 ctctagttaa ccagttggga aacattaaga acaggtattt gaatgaaata gttcattcaa
      721 cctcaaaaag ccaactacag gaactgatga tgaagagtca atcagaagta gatgaagctg
      781 tgtctaaatt tgaaaaggac tcattttctt cgtcaagttc aggatcctcc actaaaccag
      841 aaactccgca gccggaaaat ccagagcatc aaaaaccaac aactccatct ccggatacca
      901 aaccaagccc tcaaccagaa ggcaagaaac caagcgtacc agacattaat caggaaaaag
      961 aaaaagctaa gcttgctgta gtaacctaca tgagcaagat tttagatgat atacaaaaac
     1021 atcatctgca gaaagaaaaa catcgtcaga ttgttgctct tattaaggag cttgatgagc
     1081 ttaaaaagca agctctttct gaaattgata atgtaaatac caaagtagaa attgaaaata
     1141 cagtccacaa gatatttgca gacatggatg cagttgtgac taaattcaaa aaaggcttaa
     1201 ctcaggacac accaaaagaa ccaggtaaca aaaaaccatc tgctccaaaa ccaggtatgc
     1261 aaccaagtcc tcaaccagag gttaaaccgc agccggaaaa accaaaacca gaggttaaac
     1321 cgcaaccaga aaaaccaaaa ccagaggtta aaccgcagcc ggaaaaacca aaaccagata
     1381 atagcaagcc acaagcagat gataagaagc catcaactac aaataattta agcaaggaca
     1441 agcaaccttc taaccaagct tcaacaaacg aaaaagcaac aaataaaccg aagaagtcat
     1501 tgccatcaac tggatctatt tcaaatctag cacttgaaat tgcaggtctt cttaccttgg
     1561 cgggggcaac cattcttgct aagaaaagaa tgaaatagtg attgattcat tcaaaaatgt
     1621 ttgtaaaaag tattcggctt aaaagaaaag agtctgggat aaaaagattt tgattttagg
     1681 aattctttat tataaatttt taaaatcgat agattagaca aaaaagcgaa caagacagaa
     1741 ttctgagtgt cagataactg attttgttcg ctttttatat ttaatattat acttttgtcc
     1801 taggctcttt tttgcattat actttttcca attgcaagag ggcttcaatc tctgccaggg
     1861 tgctagcttg cgaaatggct ccacggagtt tggcagcgcc agatgttccc cggagatagt
     1921 gaggagcgag gccgcggaat tcacgaactg cgacgttttc tcctttgagg ttaatcaatc
     1981 gtttcaagtg ttcgtaggcg atcttcatct tgtcttcaaa ggtcaaatca ggtaggattt
     2041 ctcctgtttc aaagtaatgg ttgatttggt tgaagaggta aggatttccc atggcagctc
     2101 ggccaatcat gactgcgtca gcaccaactt cttcgatgcg ttgcttggct tcttggacag
     2161 tacggatatc accgttggcg atgaatggaa tcttggttag agcttgggca accttgtaaa
     2221 gggtctcaag gtctgcgtgg ccagtataca tttgttcacg ggtacggcca tgcatggcga
     2281 gggcagaaac acctgcagcc tcagcagcga gggcattttc tactgcaaga gatgggtccg
     2341 cccagccggt acgcattttg acagtaagtg ggatatcaag gacagactgg accttgttga
     2401 tgatagagta gatcttgtca ggatccttga gccacatagc tccagcttcg ttcttcacga
     2461 ttttgttgac agggcagccc atgttgatat cgacgatatc ggtcttggtg ttttcttgga
     2521 tgaattctgc tgcgcgtgct aggctgtctt catcgctacc aaaaagttgg atagagacag
     2581 ggttttcgcc ctcatcgata tgaagcatgt gcagggtttt ttcgttgttg tattggattc
     2641 ccttgtcaga gaccatttcc attacaacga gtccagctcc gagctctttt gcgatggtac
     2701 gaaaggctga gttggtcacg ccagccatag gcgctaaaac ggtacgattg ggaatctcaa
     2761 cattgccaat cataaaaggt gtattaagat ttgtcacgaa tgagttcctc caggtccttt
     2821 tcatcaaagt tgtaagtagt ttggcagaat tgacaagtga tttctacccc gtggtcttcc
     2881 tctttcattt cctgtaagtc tgagcttgga aggctggcaa gagcgttcat aaagcgttca
     2941 tggctacagt cacattggaa acggatttct tcttcagaaa gacgcttgta ggcttcgtcc
     3001 ccgtagatag ccttgaggag ggcttcgata tggtcgtcgc tttcgagaag agtagagata
     3061 gctggcattt cttggatgcg tttttcaaag cgagcaatct cttctttctt ggctcctggc
     3121 aagacttgaa ctaggaaacc acctgcaatc ttgaccttgt cttcctcgtc caaaaggaca
     3181 ttgaggccga ccgctgaagg cgtttgttgg ctttcagtaa ggtaaaaggc aaggtcttca
     3241 ccgatttctc cagagatgag gggagttata gagttgtaag gatttccagt accgtagtct
     3301 gtgataacga ggaattgacc atttccaaca aaaggtccga ctaggacttc accagtcgca
     3361 gtctttttga tgtcaacacc aggattttga acgtagcctt tgacgttccc cttggtatca
     3421 gcgacggtga taatagcacc tagagagcta gatcccaaca ccttaactgt aagtttggta
     3481 tttccttttt cattggctgc gagaatctgg ctggcgataa gagttcgacc aagcgctaca
     3541 gttgagctag cttgggtttg atgtttttct tgagcagtgc ggacggtttc agtgctatca
     3601 aggacaaaag cacgaaaggc tccgctttct gatatagttt taataatttt atccatagct
     3661 actattttag cataaaaatg cccaaagggg gagccgtgtg tttactgatt ttcaggataa
     3721 tggaccagga aatcagcatg aaaataaaaa gagaaacaga ttatttcagc atttgtaaga
     3781 tttatgctat gcttaaggta gaaaatgaaa ggggtaacaa atgtatttag gagatttgat
     3841 ggagaaagcc gagtgtggtc aattttcaat cctttccttt ctattacaag agtctcagac
     3901 gaccgtcaag gctgtaatgg aagaaacagg attttcaaaa gcaaccctaa ccaaatatgt
     3961 caccctgctc aatgacaagg ctttggatag tggcttagaa ctgactattc actcagaaga
     4021 tgaaaatctg cgtctgtcta tcggtgcagc taccaagggg agagatattc ggagcttgtt
     4081 tttggagagt gctgttaaat accagatttt ggtttatctt ttctaccacc aacagttttt
     4141 agcccatcag ctggctcaag aattggtgat tagcgaggct acgcttggtc gtcacttggc
     4201 tggtttaaat cagattttgt cagaatttga tttatccatc caaaatggac gttggcgagg
     4261 tccagagcat cagattcgct atttctattt ctgtcttttc cgaaaggtct ggtcgagtca
     4321 ggaatgggaa ggtcacatgc agaaaccaga gagaaaacag gagattgcca atttagagga
     4381 aatctgcggt gcaagtttgt ctgtggggca gaaattggac ttggttctct gggctcacat
     4441 cagtcaacaa cgtcttcggg tcaatgcttg tcagtttcaa gtcatagaag agaaaatgcg
     4501 agggtatttt gacaatatct tctatcttcg tttgctgaga aaggttccgt ccttttttgc
     4561 tgggcaacat attccactag gagttgagga tggtgagatg atgatattct tctcttttct
     4621 cctatctcat cgcattcttc ctcttcatac tatggagtat attcttggtt ttggagggca
     4681 gttggcagat ttactgacgc aattgattca agaaatgaag aaggaggaac tattggggga
     4741 ttatacagag gaccatgtca cctatgaact cagtcagctt tgtgctcaag tctatctcta
     4801 taagggctat attttacagg atcgctacaa gtaccagtta gagaatcgtc atccatattt
     4861 actgatggaa catgatttta aagagacagc agaggagatt tttcatgctc tacctgcttt
     4921 tcaacagggg acagatttag ataagaagat tctctgggaa tggctccagt taatcgaata
     4981 tatggctgaa aacggtggtc agcatatgcg gattggtctg gatttgacat ctggttttct
     5041 tgtcttttca aggatggcag ccattttgaa acggtatttg gaatacaatc gttttattac
     5101 cattgaagct tatgacccta gtcggcatta tgatttgctg gttaccaata acccgattca
     5161 taagaaggaa cagacaccag tctattattt aaaaaatgac ttggatatgg aggatttggt
     5221 agcgattcgc cagttattat tcacttaaaa ggcttggtta atccaggtct tttttgtgaa
     5281 attcacacaa tctcctcaca tttttttaaa aattaaaaaa agttgataaa caagaaagcg
     5341 ctttattttg tatactagta agtgtaaaga ggaaacacct caagatcttt atcaggagga
     5401 cagtacatgt cacaagaaaa atacatcatg gccattgacc agggaactac aagttctcgt
     5461 gccatcattt tcaacaaaaa aggggaaaag gttagctcga gtcaaaaaga gtttacccag
     5521 attttccctc aagcaggttg ggttgagcac aatgccaatg aaatttggaa ctctgttcag
     5581 tcagttattg cgggtgcttt catcgaaagt ggtgtcaagc caaatcaaat cgaggcaatc
     5641 gggattacca accaacgtga aacaacggtt gtctgggata agaaaacagg acttcctatc
     5701 tacaatgcta tcgtttggca gtcacgccag acagcacctt tggctgagca actaaaaagc
     5761 caaggttatg tggaaaaatt ccatgaaaag actggtttga ttattgatgc ttacttctct
     5821 gctaccaagg ttcgttggat tttggatcat gtagaaggtg ctcaagagcg agcagaaaaa
     5881 ggggaattgc tctttggtac tatcgatact tggttggttt ggaaattgac tgacggtgcg
     5941 gctcacgtga ctgactactc aaatgcagct cgtaccatgc tttataacat taaagaactc
     6001 aaatgggatg atgagatttt ggaaatcctt aacattccga aggctatact tccagaagtt
     6061 cgttctaact ccgaaatcta cggcaagaca gctccattcc atttctacgg tggagaggtg
     6121 ccaatctcag gtatggctgg ggaccaacaa gcagccctct ttggacagtt ggcttttgag
     6181 ccaggtatgg ttaagaatac ttatggaaca ggctctttca tcatcatgaa tactggggaa
     6241 gagatgcagt tgtctgaaaa caacctcttg acaaccattg gttacggaat caacggtaag
     6301 gtttattatg ccttggaagg ttctatcttc atcgcaggaa gtgctattca gtggcttcgt
     6361 gacggtcttc gcatggttga aaattcacca gaatctgaaa aatacgctcg tgattctcac
     6421 aacaacgatg aagtttatgt cgttccagcc tttacaggtc taggcgctcc atactggaac
     6481 caaaatgctc gtggttccgt ctttggtttg actcgtggaa caagcaaaga agactttatc
     6541 aaggcgactt tgcaatctat tgcttatcaa gtgcgtgata tcatcgacac catgcaagtg
     6601 gatactcaga ccgccattca agtactgaag gtggatggtg gtgcagccat gaacaacttc
     6661 ctcatgcagt tccaggcgga tattttaggc attgacattg cacgtgctaa aaacctggaa
     6721 acaacagctc taggagcggc cttcctagca ggtttgtcag tagggtactg gaaagacttg
     6781 gacgagttga aactcttgaa cgagacagga gaactctttg agccatctat gaacgaatct
     6841 cgcaaggaac aactctacaa gggctggaag aaggctgtga aagcaactca agtctttgcg
     6901 gaagtagacg actaatactg gcagaataaa gcgatttatt tagaaagtgt gtaaatatgg
     6961 aattttcaaa gaaaacacgt gaattgtcaa ttaaaaaaat gcaggaacgt accctggacc
     7021 tcttgattat cggtggagga atcacaggag ctggtgtagc cttgcaggcg gcagctagcg
     7081 gtcttgagac tggtttgatt gaaatgcaag actttgcaga aggaacatct agtcgttcaa
     7141 caaaattggt tcacggagga cttcgttacc tcaaacaatt cgacgtagaa gtggtctcag
     7201 atacggtttc tgaacgtgca gtggttcaac aaatcgctcc acacattcca aaatcagatc
     7261 caatgctctt accagtttac gatgaagatg gagcaacctt tagcctcttc cgtcttaaag
     7321 tagccatgga cttgtacgac ctcttggcag gtgttagcaa cacaccaact gcgaacaagg
     7381 ttttgagcaa ggatcaagtc ttggaacgcc agccaaactt gaagaaggaa ggcttggtag
     7441 gaggtggagt gtatcttgac ttccgtaaca acgatgcgcg tctcgtgatt gaaaacatca
     7501 aacgtgccaa ccaagacggt gccctcattg ccaaccacgt gaaggcagaa ggcttccttt
     7561 ttgacgaaag tggcaagatt acaggtgttg tagctcgtga tctcttgaca gaccaagtat
     7621 ttgaaatcaa ggcccgtctg gttattaata caacaggtcc ttggagtgat aaagtacgta
     7681 atttgtctaa taagggaacg caattctcac aaatgcgccc aactaaggga gttcacttgg
     7741 tagtggattc aagcaaaatc aaggtttcac agccagttta ctttgacaca ggtttgggtg
     7801 acggtcgtat ggtctttgtt ctcccacgtg aaaacaagac ttactttggt acaactgata
     7861 cagactacac aggtgatttg gagcatccaa aagtaactca agaagatgta gattatctac
     7921 ttggcattgt caacaaccgc tttccagaat ccaacatcac cattgatgat atcgaaagca
     7981 gctgggcagg tcttcgtcca ttgattgcag ggaacagtgc ctctgactat aatggtggaa
     8041 ataacggtac catcagtgat gaaagctttg acaacttgat tgcgactgtt gaatcttatc
     8101 tctccaaaga aaaaacacgt gaagatgttg agtctgctgt cagcaagctt gaaagtagca
     8161 catctgagaa atatttggat ccatctgcag tttctcgtgg gtctagcttg gaccgtgatg
     8221 acaatggtct tttgactctt gctggcggta aaatcacaga ctaccgtaag atggctgaag
     8281 gagctatgga gcgcgtggtt gacatcctca aagcagaatt tgaccgtagc tttaaattaa
     8341 tcaattctaa aacttaccct gtttcaggtg gagaattgaa cccagcaaat gtggattcag
     8401 aaatcgaagc ctttgcgcaa cttggagtat cacgtggttt ggatagcaag gaagctcact
     8461 atctggcaaa tctttacggt tcaaatgcac cgaaagtctt tgcacttgct cacagcttgg
     8521 aacaagcgcc aggactcagc ttggcagata ccttgtccct tcactatgca atgcgcaacg
     8581 agttggctct tagcccagtt gacttccttc ttcgtcgtac caaccatatg ctctttatgc
     8641 gtgatagctt ggatagcatc gttgagccag ttttggatga aatgggacga ttctatgact
     8701 ggacagaaga agaaaaagca acttaccgtg ctgatgtcga agcagctctc gctaacaacg
     8761 atttagcaga attaaaaaat taagaaaaaa taaaagaggt ggagggcagc attccttgtc
     8821 gcccgtccct tctttttaat ggagacagaa agatgatgaa tgaattattt ggagaatttc
     8881 tagggacttt aatcctgatt cttctaggaa atggtgttgt tgcaggtgtg gttcttccta
     8941 aaaccaagag caatagctca ggttggattg tgattactat gggttggggg attgcagttg
     9001 cggttgcagt ctttgtatct ggcaagctca gtccagctca tttaaatcca gctgtgacag
     9061 ttggtgtagc tttaaaaggt gacttgcctt gggcttccgt tttgccttat atcttagccc
     9121 agttcgcagg ggccatgctg ggtcagattt tggtttggtt gcaattcaaa cctcactatg
     9181 aggcagaaga aaatgcaggc aatatcctgg caaccttcag tactggacca gccatcaagg
     9241 atactgtatc aaacttgatt agcgaaatcc ttggaacctt tgttttggtg ttgacaatct
     9301 ttgctttggg tctttacgat tttcaggcag gtatcggaac ctttgcagtg ggaactttga
     9361 ttgtcggtat cggtctatca ctaggtggga caacaggtta tgccttgaac ccagctcgtg
     9421 accttggacc tcgtatcatg cacagcatct tgccaattcc aaacaaggga gacggagact
     9481 ggtcttacgc ttggattcct gttgtaggcc ctgttatcgg agcagccttg gcagtgcttg
     9541 tattctcact tttctagttt atactcttcg aaaatcaaat tcaaaccacg tcagcgtcgc
     9601 cttaccgtac tcaagtacag cttgcggcta gcttcctagt ttgctctttg attttcattg
     9661 agtattagaa aacaattatt ttgatagagc ttgggcaaga gcccaatttc agcaaaaaat
     9721 gaagtaaatc ttctcataat aaaacgcatc atatcaagca cgaaaattcc acgaggtcaa
     9781 ctacagtcag aaagctgaac aacaagccaa aacgcccaaa aaaggcggca aaaagcaagc
     9841 acctgcaagc aacgtgccga aatggtcaaa tcctgattat gtcaacgaat tagacccaaa
     9901 aatcgttgat atgctagtag aatttcacaa gtcacaaggc actttggaaa ctcccgaggc
     9961 gcaagcagaa atcgcccaaa aacgtgaaga aatcgagcaa aggagagctg agcttgagga
    10021 taaaaaacaa gagcttttga accgcttgaa caaatagagt ttcgcaagta ttatgcttac
    10081 aaattacttg agcaattaac taaaatataa accctgccta gatataaagg cagggtttat
    10141 attttagaaa ttcacgtagg ttgttacggt ttttacatac ccagtatagt ttgagtttct
    10201 atagtattca gtgataaact tccattttct ttgagcaaca tggatataag tacttgttat
    10261 gtagtatgga tatgggcttt gtgaatccaa gtaagactga taagcttgta taccaaaata
    10321 tgctccacca attattgcac cccatggacc ccccaataaa gcacctatcc taccaatcat
    10381 ataactgatt ccagcaccag tcatgaagtt agcgaatgtg ttagcttgtt tattcccatg
    10441 tattgtgttg acgtaattcc aaacattagg atcgtatgat ctaaaagata tatttaggtc
    10501 gatttcattc ttttgataag ccatataaaa tgccccattg atatagacgc cgtcagcacg
    10561 tcgttcaata gtgtctacac ttccatctgg attgacaacc tcaagaactt catcgcttaa
    10621 aatatttact tgcgtatctc cgaaccgcac tgatgagcca ttctcaaact gagcctcacc
    10681 agatacaact ttagagtttg ccgataagct atcatcagca aaaacaacaa gcgacgggga
    10741 aatgctagac atacagaaaa cagacataac tagcaaacac atgcatttaa acatcttaga
    10801 cataacggaa actcttttgt atttttgatt tttttcaact tttattatac aataaaacca
    10861 aataaaaaga aagcggtaac aatatgctta atgcgaaaat tttttatata tttttatgtt
    10921 tgatcgttat cgaaactaca ggcttgttgt tgttgaaaag aggtctcgaa atgggttatt
    10981 tagacacaga agctattatc ctagcagttt tttcatttgc tttttacaac ctatgttcat
    11041 tcgcttgggt ctgctctaca ataaaaaaca ataaaaaata aatagacgta ttttcaaaaa
    11101 aaaaaatgca tatttatatt agcaaaatga cgatttaaat cgtcgttttt ttgtagtacg
    11161 acgggcatgt cgtatatctg aggtgtaagt cctcggtggg cacctgctac cggtgaaccc
    11221 aatagcgatt cccaagcctg actatcgtga ggtagcggat taaaacggtc tggggataga
    11281 ccgttttaag tctgacgcag gaaataagaa tcgtcagagg aagggatagc gaaatcgtgg
    11341 ctctacgaac aggaacgtga tagtaaggcg tatatagcgg ataaggaggc ttcaaactct
    11401 aaagtccaaa aaggtagtcg taacctatat gtgtaaatca cgagagtaat tgaattcgga
    11461 ctaaggtttg tgtgaaaaag ataaatcttt ctagagtcta aagactctgc gtcagatttc
    11521 ctattttcac tgtaaccttt taacgtcctc atatcttgta taaacgagga aagatgtacg
    11581 acttatcccg tgaggtttca tgagcgctga aagcgtagta acaacgaatc atgagaagtc
    11641 agccgagccc atagtagtga ggaaacttct gtagtggaag tggagcgaag gggtgaatac
    11701 tcaaacagtc tggggagaga ctgtttgagg tctgtcgcta gaaagagaaa acgacagatc
    11761 gaagtaatcc tacttcactt gtgtctgtaa aatgagtggt ctgatagaac tggactttga
    11821 cacgtaatga ctagatgaag gttcaccaat ataagatgtc cctcaggcac caaaacaaga
    11881 aaggaatacg cacatgtcaa aactgctaga taagatatta tcacgcgaaa atatgctgga
    11941 agcctacaat caagtaaaat ccaataaagg ctcagctggg attgatggaa tgactatcga
    12001 agagatggat aattatctca gacaaaactg gcgcttgact aaggaactga taaaacagag
    12061 aaaatataag cctcaaccaa ttcttaaagt tgagatacct aaaccagacg gaggcatccg
    12121 tcaactagga atttcaacag ttatggatag aatgattcaa caggccattg tccaagtcat
    12181 gagccccatt tgtgaacccc atttctcaga tacgagttat ggtttcagac caaataggtc
    12241 atgtgaaaaa gccatcatga agctcttaga atacttaaat gacggctatg agtagatagt
    12301 ggatatagac ctagagaaat ttttcgatac agttcctcaa gatagattga tgtccttagt
    12361 acataacatt atcgaagacg gagatacgga atccttgatt cgtaagtatc ttcattcagg
    12421 tgttatcatt aatggtcaac gttataaaac actagttggt acaccacagg gaggaaattt
    12481 atctcctctc ttatccaata tcatgcttaa tgaattggac aaggaattag aaaagagggg
    12541 acttcgattt gtgcgctacg cagatgattg tgtgatacgg tcggaagcga ggcagccgct
    12601 aagcgtgtga tgtattcagt cagtcgtttt attgagaaac ggctaggttt gaaagtaaac
    12661 atgaccaaga ctaagattac cagaccaaga gagttgaaat atctaggttt tgggttctgg
    12721 aaatcatcag atggttggaa aagccgtcca catcaagata gtgttcggag atttaagttt
    12781 aaattgaaga aactaacaca gaggaaatgg agtatagacc taacaagacg tattgagcaa
    12841 ctgaatttgt ctattcgagg atggataaac tatttctcat tgggaaatat gaaaagtata
    12901 gtcgccagca tagatgagcg cttgcgtact cgcctacgag tgattatctg gaagcaatgg
    12961 aagaagaaat cgagacgatt atggggattg cttaagttag gagttcctaa atggatagca
    13021 gataaggtat ctggctgggg cgaccattat caattagtag ctcagaagtc ggtacttaaa
    13081 cgtgctatat caaaaccagt ccttgaaaaa cgtggactgg tttcgtgttt ggattattac
    13141 cttgaacgac atgcgttaaa agttagttga accgccgtat gccgaacggc acgtacggtg
    13201 gtgtgagagg ggctagagat tatcccctac tcgattaact cccctgaaat ttattttaat
    13261 tatgcaaatt tcacgtattt ttgatgctga gacgacgatc ctgggaactt ttcagatatt
    13321 tttttgacta tctaaatcta tcattagaaa agcttagagc gccaaaggat ttgagcgttt
    13381 ttctgatttt taagactttt tcccagtctc tttttcgatt gaagatgtaa ttattctact
    13441 aactaactaa cttcttagta ctagccaaca acgataatca taattcctcc taaaattagg
    13501 aataataaag gcaatagttt ttgttttttc atgtaaaaaa cctcactttt gttttctgct
    13561 attttatgct aaaatattaa aaatcaaatt taattccaaa gtttgtaact aaagggggag
    13621 cgctacatgt ctaattcatt tgtcaagttg ttagtctctc aattatttgc aaatttagca
    13681 gatattttct ttagagtaac aatcattgct aacatataca ttatttcaaa atcagtaatt
    13741 gccacatcac tagttcctat cttaatagga atatcctctt ttgttgcgag tcttttagtt
    13801 ccgttggtta ctaaaaggtt agcgctaaat agggttttat ctttatctca atttggaaag
    13861 actatattat tggcgatact ggtaggaatg tttaccgtaa tgcaatccgt agcgcctttg
    13921 gtgacctatc tatttgttgt tgcaatttcc atactagatg gttttgcagc acccgtttcc
    13981 tatgctattg tgccacgcta tgcgaccgat ttgggtaagg ctaattcagc cttatcaatg
    14041 actggtgaag ctgttcaatt gataggttgg ggattaggtg gactcttgtt tgcaacaatt
    14101 ggtctgttac ctaccacgtt tatcatttta gtcttgtata tcatttctag ctttctgatg
    14161 ttatttcttc ctaacgctga agtggaggtg ttagagtcag aaactaatct tgaaattttg
    14221 ctcaaaggtt ggaagttagt tgctagaaat cctagattaa gacttttgta tcagcaaatt
    14281 tattggaaat tttttcaaat acgatttggg tttcttccat tatacttgtt tttgtaacgg
    14341 agttattaaa taaaacggaa agttactggg gatattctaa tacagcatac tctattggta
    14401 ttataattag tggcttaatt gcttttaggc tatctgaaaa gttccttgct gctaaatggg
    14461 aaagtattct ttttcctctt gtagctatgg caatagtgac actgactatt ctatattttc
    14521 caaacgcaca gatgttttta ttattttcag ctttagttgg tatgttatcg caactaaaag
    14581 aagttcctga aagtgtattt cttcaggaaa cagtagagga aaatcattta gttaatgtct
    14641 attccgttct tgaagtgatt tctacattag cattttcagt atttgttttg ctaatgagct
    14701 atattactga gagttttggt attagcatca gtttttggct atcagccatt tgtctgatga
    14761 tagaagctat tttaatttat atcagacgag attattttaa atgagagagt ggttaaaaag
    14821 tctttaaaaa tcagaaaagc gcatagtatc aggtgttgaa aaaacttgat attgtgtgtt
    14881 ttattatgag aagatttact tcattgtctc ctgaaatgga gttttgaagc aggatcactc
    14941 tatttgaaaa tatacataga aaaactgtat aatccttaaa ataagctgaa atctattgga
    15001 aacatacggt aaacaattga aaagatacta tataaagtgg tacaatggta gaaaaataag
    15061 ctagtaagaa tcactcttat tttagcgaaa aattacagaa atgaatggtt tttcttgatg
    15121 aaacagagaa aagaattgta cctctttctt ggtcggacag ccttgtattt tcttatcttt
    15181 ctagggctgc tttacttctt tagctatctt ggtcagggtc aaggaagctt tatctataat
    15241 gaattttaac ttgaaggaga atccctattg tgtcaaataa accaatagca gatatgattg
    15301 aaaccattga gcattttgct cagacacagc ctagctatcc tgtctataat gttttggggc
    15361 aggaacacac ttatggcgat ttaaaggctg attcggatag tttggctgca gtcattgccc
    15421 aactaggctt gcctgagaag tctcctgtgg ttgtttttgg tggccaagaa tatgaaatgt
    15481 tggcaacctt tgtagcgctg actaagtcag gtcatgccta cattccaatt gatagccatt
    15541 cggccttgga gcgagtttca gctattttag aagtagcaga gccaagcttg attattgcca
    15601 tttcagcctt tcccttggag caggtttcta caccaatgat aaatctagct caggttcaag
    15661 aagcctttgc ccaagggaac aactatgaaa tcacgcatcc agtcaaggga gatgataatt
    15721 actacattat ctttacttct ggtacgactg gtaagcctaa gggagtgcag atttcacatg
    15781 ataatctcct cagctttaca aactggatga ttacggataa ggaatttgcg acaccgagtc
    15841 gtccgcaaat gctggcacag ccaccttatt cttttgactt gtctgtcatg tattgggcac
    15901 cgaccttggc acttggtggt acgcttttca ctcttccttc agtcatcact caggacttta
    15961 agcaactctt tgcggctatc ttttcattgc caatcgctat ctggacatca acaccatcct
    16021 ttgcagatat ggccatgttg tctgaatact tcaacagtga gaaaatgcct ggaatcacgc
    16081 atttctactt tgatggtgaa gaattgacgg tcaaaacagc tcaaaaactg cgcgagcgtt
    16141 tcccaaatgc ccgtatcatc aatgcttacg gcccaacaga agcgacagta gctctgtcag
    16201 cagttgccgt gacagacgag atgttagcga ctctcaaacg cctaccaatc ggctatacca
    16261 aggctgattc tccaaccttt atcattgacg aggaaggaaa taaactgcca aatggtgagc
    16321 agggagaaat cattgtttct gggccagctg tttcaaaagg ttatatgaaa aatcctgaaa
    16381 aaacagcaga agccttcttt gagtttgaag gtctgccagc ctatcacaca ggcgatgtgg
    16441 gaaccatgac agatgagggc ttgcttctct acggcggacg catggacttc cagattaagt
    16501 ttaacggtta ccgcattgag ttagaagatg tctctcaaaa cctcaacaag tctcgcttta
    16561 tcgaatctgc tgtcgcagta ccgcgctata acaaggacca caaggtacaa aatctattgg
    16621 cttatgtcat cttaaaagac ggtgttcgtg agcagtttga gcgagatatc gatattacca
    16681 aggccatcaa ggaagacctg acagacatca tgatgtccta tatgatgcca tctaaattcc
    16741 tttaccgaga cagtttgcca ctaactccaa atggaaagat tgacatcaaa ggattgatta
    16801 acgaggtgaa taagagatga tggagttttt tcaacagctt cctcatttag agccatatgg
    16861 caatcctcag tattttgttt atgtgattgc tgcaaccttg cccatcttta taggtctctt
    16921 tttcaagaaa cgctttgcct ggtatgaagt gttggtaagt ctcttcttta ttgtcaccat
    16981 gttggtgggt ggaaagacca atcaactagc tgccttgggt atttaccttt gctgggaaat
    17041 attgctcctg cttttctaca agcattatcg aaaaagcaag gatggcaagt gggtcttcta
    17101 cttagttagt tttctgtccc tacttccgat tatctttgtc aaggtgcaac cagctatcaa
    17161 tggaacgcag tctttgcttg ggttcttggg aatttcttac ctgacctttc gttcggttgg
    17221 gattatcatc gagctgagag atggagtgat taaggatttt accctctggg aattcctccg
    17281 tttccttctc ttcatgccaa ctttctcgag tggtccaatc gatcgcttta agcgatttaa
    17341 tgaaaattat caggccattc ctgagcgaga tgagttgatg gatatgctgg atgaatctgt
    17401 ccgctatatc atgcggggct ttttgtataa gtttatccta gctcatgttt taggagagac
    17461 cttactacct cctctgaaga atttagcctt gcagtcaggt ggcttcttta atctctatgc
    17521 cttggcagtt atgtatactt ttggtctgga actcttcttt gactttgcag gttattctat
    17581 gtttgctttg gccatctcaa acttgatggg aatccgtagc cctatcaact ttaacaagcc
    17641 ctttttatca agggatttaa aggagttttg gaatcgctgg catatgagtc tgtccttctg
    17701 gttccgtgac tttgtcttta tgcgaatggt gatggtgtta accagaaaga aagtctttaa
    17761 aaatcgtaat gtaacctcaa gcatggccta cattgtaaat atgctgatta tgggattttg
    17821 gcatggtgtg acctggtact atatcgccta tggactcttt catggactag gcttggtcat
    17881 caatgatgcc tgggttcgca agaaaaaaac gctcaataag gaacggaaaa aagcagggaa
    17941 ggctgcccta cctgagaatc gctggattca gttgcttggc atggttgtca ctttccatgt
    18001 tgtcatgttg tcattcttaa tcttttctgg attcttgaat aatctatggt ttaaaaaata
    18061 aaaggaaata aaatatggat atcaaatcag aagttattga aattattgat gagttgttta
    18121 tggaagatgt ttctgacatg atggatgaag atctttttga tgcaggtgtc ttggatagta
    18181 tgggaacggt tgagttgatt gtggagattg agaaccgttt tgacattcgt gtccctgtaa
    18241 cagagtttgg tcgtgacgac tggaatacag ctaataaaat catagctggt attgtggagc
    18301 tacaaaatgc ttaaacgctt atggatgatc ttcggaccgg tcttgatcgc tggtttgttg
    18361 gtttttctgc tcattttctt ttatcctact gagatgcatc ataatctagg agctgaaaag
    18421 cgttcagcag tggctactac tatcgatagt tttaaggagc gaagtcaaaa agtcagagca
    18481 ctatctgatc caaatgtgcg ttttgttccc ttctttggct ctagtgaatg gcttcgtttt
    18541 gacggtgctc atcctgcggt attagctgag aaatacaatc gttcctaccg tccttatctt
    18601 ttaggacagg ggggagctgc atcgcttaac caatattttg gaatgcaaca gatgttacca
    18661 cagctggaga ataaacaagt tgtgtatgtt atctcacctc agtggttcag taaaaatggc
    18721 tatgatccag cagccttcca gcagtatttt aatggagacc agttgactag ttttctgaaa
    18781 catcaatctg gggatcaggc tagtcaatat gcagcgactc gcttactgca acagttccca
    18841 aacgtagcta tgaaggacct ggttcagaag ttggcaagta aagaagaatt gtcgacagca
    18901 gacaatgaaa tgattgaatt attggctcgt tttaatgaac gccaagcttc cttttttggt
    18961 cagttttcgg ttagaggcta tgttaactac gataagcatg tagctaagta tttaaaaatc
    19021 ttgccagacc agttttctta tcaggcaata gaagatgttg tcaaagcaga tgctgaaaaa
    19081 aatacttcca ataatgagat gggaatggaa aattatttct ataatgagca gatcaagaag
    19141 gatttgaaga aattaaagga ttctcagaaa agctttacct atctcaagtc gccagagtat
    19201 aatgacttgc agttggtttt aacacagttt tctaaatcta aggtaaaccc gatttttatc
    19261 attccacctg ttaataaaaa atggatggac tatgctggtc tacgagagga tatgtaccaa
    19321 caaacggtgc agaagattcg ctaccagtta gaaagtcaag gttttaccaa tatagcagat
    19381 ttttctaagg acggcgggga gcctttcttt atgaaggaca ccattcacct tggttggttg
    19441 ggttggttgg cttttgacaa ggcagttgat cctttcctat ccaatcccac accagctccg
    19501 acttaccatc tgaatgagcg ctttttcagc aaagattggg cgacttatga tggagatgtc
    19561 aaagaatttc aatagataat ataatataga agagttcaag aatgaaacta gttttcacgt
    19621 tttttcttga ctcttttttt gcttgtgata taattaactg gtaaacaaaa tgtcaaagaa
    19681 tagtattttt ctcttaaaaa agagaagtct aaaaggaaag gagtcagata tgagacagct
    19741 agcaaaggat atcaatgctt ttttgaatga ggtgattttg caggcggaaa atcagcatga
    19801 aatcctaata ggtcattgca ctagcgaggt ggccctgacc aatactcagg agcatatcct
    19861 tatgctcttg tcagaggaat ctttaacaaa ttcagaattg gctcgtcgtc tcaatgtcag
    19921 tcaggcggca gttaccaagg ccattaagtc tttggtcaag gaagggatgt tggaaacatc
    19981 taaagattct aaagatgcgc gtgtgatttt ttatcagttg actgacttgg ctcgtccaat
    20041 cgctgaggag caccaccatc accatgagca tacactttta acctatgaac aagtggcgac
    20101 tcagtttact ccaaatgaac aaaaagtgat tcagcggttt ttgactgctt tagtaggaga
    20161 aatcaaataa tgagatatat tacggtagag gatttgtcct tctattatga taaggagcct
    20221 gttcttgaac atatcaatta tagtgttgat agtggggaat ttgttacctt gactggggaa
    20281 aatggagcgg ctaagacgac gctcatcaag gctagtcttg gaattctgca accacgcatt
    20341 ggaaaggtgg ctatttcaaa gacaaatacg caaggtaaga aattgagaat agcctatctt
    20401 cctcaacaaa ttgccagttt taatgctggt tttccaagta cggtctatga atttgtcaag
    20461 tcgggtcgct atccgagaaa aggctggttc cgtcgtttga atgctcatga tgaggagcat
    20521 atcaaggcta gtctggactc agttggcatg tgggaacatc gagacaaacg cttggggtct
    20581 ctatctgggg gacaaaagca gcgagcggtg attgcgcgta tgtttgcttc tgaccctgat
    20641 gtgtttatcc tagacgagcc gacaacgggg atggatgcag gaagtaaaaa tgaattttac
    20701 gaactcatgc accacagcgc ccatcatcat ggcaaggctg ttttgatgat tacccatgac
    20761 cctgaagaag ttaaggatta tgcggatcgc aatattcatc tagtccgtaa ccaagactcg
    20821 ccatggcgtt gtttcaacgt tcatgagaat ggccaggagg tgggccatgc ttagtttatt
    20881 atcttatgac tttatacaac gcgccttttt ggcggttatt gctatgagtc ttttctcacc
    20941 ggtattggga accttcctca tcttgcgtcg tcagagtttg atgagtgata cccttagcca
    21001 cgtctcactt tcaggtgtag cctttggtct ggttttgggg atttctccaa ctgtttctac
    21061 tattgccatt gtcttgattg cggcggtctt tctggagtat ctccgtacgg tttacaagag
    21121 ctttatggaa atcgggacag ctatcctcat gtcaacaggt ttggctgttt ctctgattgt
    21181 catgagcaag ggtagaagct cgagttcaat gagtttggac caatatctct ttggttcgat
    21241 cgtgactatc agtgaagaac aggtcatttc cctctttgtc attgcggcgg ttgttttgat
    21301 tttgaccttt ctctttcttc gtcctatgta tatcttaact tttgatgaag atacggcctt
    21361 tgtggatggc ttgccagttc gtaccatgtc cattcttttt aacatggtga caggggtggc
    21421 tattgccctt atgattcctg cagcaggagc tcttctggta tcgaccatta tggtcttgcc
    21481 agctagtatt gccctgcgtc tggggaaaaa ctttaaatcg gttatgctgc ttgccagtgc
    21541 gattggcttt ttgggaatgg tagcaggact ttacatttcc tactatgcag aaacacctgc
    21601 aagtgcaagt attaccatta tttttgtaac tgtctttata ctaatcagtt tagtaagacg
    21661 ttttatcaaa taggagacga acgtgaaaaa aattagctta ttactagcca gtctatgtgc
    21721 cttgttttta gtggcttgtt ccaatcaaaa acaggcagat ggtaaactca atatcgtgac
    21781 aaccttttac cctgtctatg aatttaccaa gcaagtcgca ggagatacgg ctaatgtaga
    21841 actcctaatc ggtgctggga cagaacctca tgaatacgaa ccatctgcca aggcagttgc
    21901 caaaatccaa gatgcagata ccttcgttta tgaaaatgaa aacatggaaa catgggtacc
    21961 taaattgcta gataccttgg ataagaaaaa agtgaaaacc atcaaggcga caggcgatat
    22021 gttgctcttg ccaggtggcg aggaagaaga gggagaccat gaccatggag aagaaggtca
    22081 tcaccatgag tttgaccccc atgtttggtt atcaccagtt cgtgccatta aactagtaga
    22141 gcacatccgc gacagcttgt cagcagatta tcctgataaa aaagagacct ttgagaagaa
    22201 tgcagctgcc tatatcgaaa aattgcaagc cttggataag gcttacgcag aaggcttgtc
    22261 tcaagcaaaa caaaagagct ttgtgactca acacgcagcc tttaactatc ttgccttgga
    22321 ctatggactc aaacaagtcg caatctcagg actttctcca gatgcagagc catcagctgc
    22381 tcgcttggca gaattgacag agtatgtcaa gaaaaataaa atcgcctata tctattttga
    22441 agaaaatgcc tcacaagccc ttgctaacac actttcaaaa gaagcaggtg tcaaaactga
    22501 tgtcctcaat cctttagaaa gtctgacaga agaggacacc aaggctggag aaaactacat
    22561 ttccgtgatg gagaaaaacc tcaaggcttt gaaacaaaca acagaccaag aaggcccagc
    22621 aatcgaacct gaaaaggcag aggataccaa gacagtccca aatggttact tcgaggatgc
    22681 agctgtcaag gaccgcacct tgagtgacta tgcaggtaac tggcaatcag tttatccttt
    22741 ccttgaagac ggcacgtttg accaagtctt tgactacaag gctaagttga ctggtaagat
    22801 gacccaggct gagtacaagg cttactatac aaaaggctat cagacagatg tgactaagat
    22861 taacattact gataatacta tggaatttgt tcaaggtgga caaagcaaga aatacactta
    22921 caagtatgtc ggtaagaaaa ttttgactta caagaaaggc aatcgtggcg tgcgtttcct
    22981 ctttgaagcc acagatgctg acgctggaca attcaagtat gttcagttta gtgaccacaa
    23041 tgttgcccca gttaaggcag aacatttcca tatcttcttt ggaggcacaa gccaagaagc
    23101 cctctttgaa gaaatggaca actggccaac ctactaccca gataacctat ctggccaaga
    23161 aatcgcccaa gaaatgttgg cgcattgatg agaaatcgac tagttcataa gagctagtcg
    23221 gttttttgat actagatggc taacttcatt atagaccttt cagaacttta aacaataaat
    23281 aaaactcttg aaatatctgg gcttatatgc tagaatgtag ttagtgtata aggttcatta
    23341 gaacaccaaa gcccctaact agtgccatag ttaagggctt ttttgacgta tcttagcgat
    23401 ttaacgggtg tttataggct agtcagtcgg tctactcctt actatctagc catctgcaga
    23461 cgaaatacaa gataattcca gctataacat ccgctataat agtaagagcg agctctatga
    23521 taaggctcat tagtttcacc ttctctcacg aacccatagg aacgtaatcg gtaaccgatg
    23581 acaaaaatag tataccacaa taaatttaga tcatcaaggt cacttaattc ttgaaatata
    23641 gggtctaggc gacaaagtct ttaaaatcag aaaaacgcat aatatcaggt gtgcaaaaac
    23701 ttgatactat gcgttttatt gtgggaaggt ttactccatt ttctcctgaa attgagtttt
    23761 tgtccagcct ctgtttttgg ggttgctaag aaaataatgt catgtggtga atatttgtaa
    23821 atcagtcagc agacagaacg aatactcttc gaaaatctct tcacatcatg tcagcttcgt
    23881 cttgccgtgt ccatggggga cttgacttca tcagttctat ctacaacctc aaaacagtgt
    23941 ttcgagctga cttgatcaat tttcaaatct gtactttgag caagctgaga ctagcttcct
    24001 atttgatttt cattgaatat cagaaaccca ttctccatca aataattcga ctgcgtctaa
    24061 taatttttga tctggcacgg tgtctgaaat aaaggttgtg tatttggaga ggggattaat
    24121 tttaaaaaat ccagtcttgt aaaatttaga actatcaatc agtaagatgg tttcatgggc
    24181 tttgtcaata gtattctttt ttgaaatagc ttggctgaga gaagcttcat aaacatattg
    24241 gtcatcaata cctcttgctg aacaaaatgc taaatcgata ttaaaatgat ctaataaaga
    24301 attttcctta tcatagttga ccacggaaca ggattgatgt ttgacctcgc cagatgtgat
    24361 aaagattttg gagctatctt taacagtttc agatagggtt tgtgcagtat gtaaaccatt
    24421 tgtaaaaata atcaaattat caagttcaga aagataggga caaagttcgt agacagtcgt
    24481 actggaatcc agatagatac acataccaga ccgaataaag tctttagcga gactagcgat
    24541 tagtcttttt tgcctagtac tttctccttc acgtatttga tgagaaagtt caattgtgtt
    24601 catagaggac agggtcacgt atccgtgctt tcttttgata agaccttgat tttctaagaa
    24661 aattaaatca cgacgtaagg tacttgtgct ggagaaagtg atttctgcca gctcttttac
    24721 ggcaattctt tttttctttt taataatttc aatcaattca agtacacgtt catcttttat
    24781 cataagctcc tcctaattta tcatttcaac tatattatag cacaaattgg aggaatttga
    24841 attattttta tgaatattgg gttaatattt gaacattatt caagtaagcg ttaatatatt
    24901 gaaaaaataa aacgtgggga ttataataaa gttaatcaag gacgaagaga gaagaaaaat
    24961 ggaagcggtt ttagcaatag atttaggtgc gacttctgga agagcaatcg ttggttacct
    25021 ttctgaaaat aaactagtaa tggaagaaat aaatcgcttt tctaatctac ctattagagt
    25081 aaaagggcat ttatcttggg atattgactt tctactagct aaaattcttg aaagtatccg
    25141 cttggctaat actagttaca agattttatc tatcggtatt gacacatggg gagttgattt
    25201 tggactgatt gataatgaag gtaagctgtt atcacaacct gttcattatc gtgatgaaag
    25261 aacaaaggga gtgttaaagg aaatatctga aatgactgaa ttagaaaaac tgtattcaga
    25321 gacaggaaat cagattatgg agataaatac cttgtttcaa ctctttaagg cacgtcaaga
    25381 atctcctgac tctttctata agaccaataa gattctttta atgccagatt tgtttaatta
    25441 tctcttgaca ggtaagtttg ctacagaaaa aagcattgct tcaacaactc aattatttga
    25501 tcctaggagt caaaattgga atcagaatat cttaaaacta tttgaattgg attcatcttt
    25561 acttcctgaa attgtttcag agggaaatgt tcttggaagg ataaaaaagg agtatggttt
    25621 aggcgatatt cctgttgtga atgtttgtag tcatgataca gcaagtgcga ttgtctcagt
    25681 acctaagaca gaaggtagtt tatttatttc atcaggtact tggtctttgg ttggagtgga
    25741 acttacttca ccgattctta ctaccgaatc cttcagttat ggatttacaa atgaagtcgg
    25801 taaagatgga gtgattacat ttctgaagaa ttgtacaggg ttgtggatca tagaggaact
    25861 aagacgttca tttgaacgaa gagggaaagc ctattctttt gatgatatta ggacaatggt
    25921 ggagaaagaa aaagaaaatc ttcctctgat tgatactgaa tcaactgaat ttgcaacaga
    25981 atctgatatg cacaagactt tgacagaata tctagcttat catcatgaaa ctagagagtg
    26041 gacagatgga caactattta agattgttta tgaaagccta gctgaaacgt ataggaaagc
    26101 gatagagtta ctagaagaac taactcataa ggtttataag aggatatatg tgattggagg
    26161 aggtgctaga gccagttact ttaaccaaat gattgctgat agaactggta aagaggttct
    26221 tacaggtttg actgaggcta cagctgtggg gaatattgtt gtgcagctca tagctatggg
    26281 acaattaaaa gggatggaag aggctcacca tgttattgag gagtttctac aattagagag
    26341 ttattactcc caaaagaatt aaaaagattg agagtttgta aatttgcctc cctccccctt
    26401 cttagctttt gtgcaggaag gggggataat tggtgaattg aaaaatattt agtgttttga
    26461 tatgaggagg acaaggatgt cagatgtaaa acaagaatta attaaatatg gtaagaagct
    26521 agtagaaaca gatttgacga aaggaacagg tgggaatctc agcgttttcg atcgtgaaaa
    26581 acaattgatg gcaattaccc cgtcgggtat tgatttcttt gaaatcaaag aatccgatat
    26641 tgtagtgatg gatattaatg gaaatgttgt agagggagaa cgcttgccat ctagcgaatg
    26701 gtatatgcat ttgattcaat atcaaactcg tgatgatatc gatgcaatta tccatgctca
    26761 tacaacttat gcaacagtat tagcttgtct cagagaacca cttccagcga gtcattatat
    26821 gattgcagtg gcagggaaag atgttcgggt agctgagtat gcaacatatg gcacgaaaga
    26881 attggctgtg aatgcagcta aagcaatgga aggtcgtaga gcagttttac tagcgaatca
    26941 tggaatttta gcaggtgcac aaaatttatt gaatgcattt aatattgttg aagaagttga
    27001 atattgtgca aaaatttatt gtttagctaa gaattttgga gagccagtag ttcttcctga
    27061 tgaggagatg gaattgatgg cagaaaaatt taaaacatac ggtcagagaa aatagggagg
    27121 atattaatgt taaaacatat accgaaaaat atttctccag atttattgaa gactttaatg
    27181 gaaatgggac atggagatga aatagtatta gctgacgcga attatccttc tgcctcatgt
    27241 gcaaataagc taattcgttg tgatggcgta aatattccag aattattaga ttccattctg
    27301 tatttaatgc cattagatag ttacgtcgat agttcaattc agtttatgaa cgttgtttcg
    27361 ggtgatgata ttcctaagat atggggtacc tatagacaga tgattgaagg tcatggtaca
    27421 gatcttaaaa cgattactta tcttagaaga gaagattttt atgaacgtag taagaaagct
    27481 tatgctattg ttgctacagg agaaacttca ctttatgcta atattatcct taagaaagga
    27541 gtagttgttg aaagagaaaa tgtttaatag aggaatttta gttgccagtc atggtgattt
    27601 tgctagcgga gctctcatga ccgcagaaat gtttgttggt gagacaacaa atgatagagt
    27661 taggacatta ggtttgatgc ctggagagaa tattgtagag tttgagcatt attttaaaaa
    27721 tcaagtggat gaactgttag actcaaatca agaggttatc gttttgactg acttgattgg
    27781 aggaagtcct aataatgtgg ctttgtcacg gtttttaaat ttggattcag ttgatattgt
    27841 aacagggttt aatattcctc tcctagtgga attaatatca aattatgatt caaaaatcaa
    27901 tttagaagaa attgttcaca atgctcaaaa tagtttgttt aatgttaaac aacaacttaa
    27961 cgtagaggag gaagaagatt tatgtctata gagtttgttc gtattgatga ccgtctggta
    28021 catggtcaag ttgtcactac gtggctaaaa aagtatgata ttgagcaagt tatcattgtt
    28081 aatgatcgca tctcagaaga taaaacacga caatctattt taaagatttc tgcaccagta
    28141 ggtttaaaaa ttgttttctt tagtgtaaaa cggtttgtgg aagttttaaa ctctgtgcca
    28201 ataaaaaaga gaacaatgct gatatataca aatccaaaag atgtgtatga ttctattgaa
    28261 ggaaatttaa aattggagta cctcaatgta ggacagatga gtaaaacgga ggaaaatgaa
    28321 aaggtaacgg gaggtgtagc tctaggtgaa gaagacaaat attattttaa gaaaatagtt
    28381 gataagggaa cgagagttga aattcaaatg gttcctaatg ataaagttac aatgttggaa
    28441 aaatttttat aaaaataatt taaggaggta cagtatatgc tattcacaca agcattactg
    28501 gtgacattag ttgggattat tgccactatt gactataatg gaccgttatt tatgattcac
    28561 cgtccgttag ttacaagtgc aatggttggc ttagtcttag gagatttcac ccaaggtgtt
    28621 cttattggtt cagctcttga attaacttgg ctcggtgtaa caggtattgg aggttacact
    28681 ccaccagata ctatttcagg tgcgattatt ggtactgcat ttggtatttt atctggtcaa
    28741 ggagaaactg ctggtatcgc tatagcagtt ccaattgcag ttgctaccca acagttggat
    28801 gttcttgcaa aaactttaga tgtttatttt gtgaaaaaag ctgataatga tgctaaaaac
    28861 ggagattatt caaagatcgg tttttatcat tattcaagtt tggttttaat cacgttattt
    28921 aaaattgtac caattttcct agctattatg cttggagggg aatatgtggc agacttgttt
    28981 gctaaggttc caccaatcgt tatgcaggga cttaactctg caggtgcttt actaccttca
    29041 attggttttg gtatgctttt aaatatgatg ctcaagaaaa atatgtgggt attcttgttg
    29101 attggattca tttgttctgt gtatggagga atgtcaacca ttgggatctc actagttggt
    29161 attgcggtag catacttcta cgatatgatt ggaagtaaac cacaagaaac aacttcaagt
    29221 agtgatgttg aggaggatct tgatctatga tgaataataa agtaactaaa gttgaactta
    29281 aaaaagtttt caaacgaagt tttatgtatg gttcttcatg gaactatgag agaatgcaga
    29341 acctaggttt tctatataca attcttccag tattgaaaaa actataccca gacaaagatt
    29401 cagcttctcc tgcaatgaaa cgtcaccttg agtttttcaa tactcatcaa acagcggcac
    29461 catttattct tggagttact tccgctatgg aagaacaaga aggaaatgaa ggtgcagctt
    29521 caattactgg tattaaagtt ggcttgatgg ggccactggc tggtctagga gatagtttgt
    29581 tctggctgac actagttcct atctgtttta gtattggtgc gtcttattct aaagacggcg
    29641 gtgctttagg tatctttatc gccttaatat tgtttaatat tattaatatt cctgttaaat
    29701 atttcggttt gaaatatggg tatactaagg gttctagtct tatccaagaa aataatacaa
    29761 aaggaacatt gaatcgcgtt acgagtatgg cgacagcatt agggctagta ctagtgggtg
    29821 gtttgattcc atcaatggtt ggtattaatt ttggattaga atttaagcag ggggaacttg
    29881 ttatttctgt tcaagaaatg attacaaaat taattccagg atttatccct atggctttga
    29941 ctttattaat gtgtaaatta attagaaaag gaaagaatcc ggttgtacta atctttagtg
    30001 ttatggctat tggagttatc ctagttgttt taggaatttt gaagtagtag aaagtgtgga
    30061 ggtggtattt gggatatcac ctccattttg gaagagaggt aaagagtgaa attatggtat
    30121 aagaaagctg cctcaaattg gaatgaagcc ttgccgattg ggaacggtca tttaggtggt
    30181 atgatttatg gttcagctac aaaagaatgt attcaactaa acgatgagac tatttggtat
    30241 agaggaaagt cagatagaaa taatccagac tcactattgc atcttaaaaa aattcgggaa
    30301 tatcttttag atggagaaat tcagaaagcc gaagaattga taaagttaac aatgtttgct
    30361 accccaagag atcaaagcca ctatgaatta cttggggaac tttacattga gcatatagat
    30421 attcagtctt gtgctctttc attgtatgaa agagagctag atttagatac agctatttct
    30481 aatgttgtgt ttgagcctaa tagttgtaat ttacaaataa aaagagaata ttttacgagt
    30541 tttaataaga atattttatg ttgccgtata gtgtcatcag ttcaaaacac attaaattta
    30601 aacattaatt tgggtagaaa taaacggttt aatgacgaag tatctaaact ggattcaagt
    30661 acaattttaa tgtcggcctc tgctggaggt agaaaaggtg ttcagtttaa agtagtatgt
    30721 cattctaagg ttacggatgg tgaagtaagt gtattgggag agacaatagt tattcggaat
    30781 gctacagagg tatttcttta tctcaaatca atgacggatt attggggaaa tatagatatt
    30841 tcttctcttc agggagaatt tagtagtatt gattacttta cagaaaaaga tgaacatgta
    30901 aaaaaatatc aggagcaatt taatagagtt gattttaaac tagactatag taaagattgt
    30961 cttagcattc caacgaatct acttcttgaa aacactaaaa agtatagtaa ctacttgact
    31021 aacttgttat ttcattatgg aagatatctg ttaatatcgt ctagtcaacc gaatggttta
    31081 cctgccaatc ttcaaggaat atggtgtgat gaattaaatc caatttgggg ttctaaatat
    31141 acgattaata ttaatactca aatgaattat tggatggtag gtccatgtga tttaccagaa
    31201 gtagaatatc cattatttga tatgctcgaa agaatgagag aaccgggaag actaaccgct
    31261 aagaaaatgt atggagctag aggttttaca gcacatcata atacggatgg ttttggcgat
    31321 acggctcccc aatctcatgc catgggggct gcaatttggg tattaactat tccatggtta
    31381 tgtactcata tttgggaaca ctatttatat ttccaagatg agcgtattct tacggaacat
    31441 tttgaaatga taaaagaagc atttcttttc tttgaagatt atttatttga ggtggatggc
    31501 tacttgatga caggtccaag tgtctcaccg gaaaataaat atcgcttaaa aaatggtatt
    31561 gaaggaaatg cttgtctatc atctacaatt gataatcaaa ttctaagata tttttgtgat
    31621 tcatgcattg gcattgcaaa acaattagga gacaattcgg attttattag tcgtgtgaag
    31681 gagttaaaaa agaaactacc taaaacaaaa ataggtagta atgggcaaat ccaagaatgg
    31741 ttagaagatt atgaagaagt agagcctggg catagacaca tttcacctct atttgggctt
    31801 tatccttata atgagattga tattcataaa actccggaat tagcagaagc agctaaaatc
    31861 actatcaata ggagattatc aaacgctaac tttttatctt cacaggagag ggagcaagcg
    31921 attaataatt ggttagtaag tggtttgcat gctagtacac aaacaggttg gagtgctgca
    31981 tggctgattc atttttttgc gagactatat caaggtgaac ctgcttataa ccagattaat
    32041 ggtttgttaa ataatgcgac tcttggcaat ttatttcttg accatccacc atttcaaatt
    32101 gatggtaatt taggtttggt gagtggaatt tgtgaattat tagtacagag ccatcataat
    32161 tggttatcac taattccagc tttaccttct gcttggtcag aaggagaagt gaaaggtttc
    32221 agagtaagag gaggatataa ggtatcgttt gcttggaaaa atggggatat aacattccta
    32281 aaattggaag gaggaaacaa agatcaaaaa gtaagagtaa gaatatatgg caaaaatact
    32341 gatgtacaaa atattgaatt ggtatttaat tcagaaaaaa ttattgagtt aaatttttag
    32401 gtataagtca tgaataaaga aaaaataaaa agaaaattaa tcacaatact gtttgtatgt
    32461 attgggatgt tatgttttgg attgttagca ggagttaagg ctgataatcg tgttcaaatg
    32521 agaacgacga ttaataatga atcgccattg ttgctttctc cgttgtatgg caatgataat
    32581 ggtaacggat tatggtgggg gaacacattg aagggagcat gggaagctat tcctgaagat
    32641 gtaaaaccat atgcagcgat tgaacttcat cctgcaaaag tctgtaaacc aacaagttgt
    32701 attccacgag atacgaaaga attgagagaa tggtatgtca agatgttgga ggaagctcaa
    32761 agtctaaaca ttccagtttt cttggttatt atgtcggctg gagagcgtaa tacagttcct
    32821 ccagagtggt tagatgaaca attccaaaag tatagtgtgt taaaaggtgt tttaaatatt
    32881 gagaattatt ggatttacaa taaccagtta gctccgcata gtgctaaata tttggaagtt
    32941 tgtgccaaat atggagcgca ttttatctgg catgatcatg aaaaatggtt ctgggaaact
    33001 attatgaatg atccgacatt ctttgaagcg agtcaaaaat atcataaaaa tttggtgttg
    33061 gcaactaaaa atacgccaat aagagatgat gcgggtacag attctatcgt tagtggattt
    33121 tggttgagtg gcttatgtga taactggggc tcatcaacag atacatggaa atggtgggaa
    33181 aaacattata caaacacatt tgaaactgga agagctaggg atatgagatc ctatgcatcg
    33241 gaaccagaat caatgattgc tatggaaatg atgaatgtat atactggggg aggcacagtt
    33301 tataatttcg aatgtgccgc gtatacattt atgacaaatg atgtaccaac tccagcattt
    33361 actaaaggta ttattccttt ctttagacat gctatacaaa atccagctcc aagtaaggaa
    33421 gaagttgtaa atagaacaaa agctgtattt tggaatggag aaggtaggat tagttcatta
    33481 aacggatttt atcaaggact ttattcgaat gatgaaacaa tgcctttata taataatggg
    33541 agatatcata ttcttcctgt aatacatgag aaaattgata aggaaaagat ttcatctata
    33601 ttccctaatg caaaaatttt gactaaaaat agtgaggaat tgtctagtaa agtcaactat
    33661 ttaaactcgc tttatccaaa actttatgaa ggagatgggt atgctcagcg tgtaggtaat
    33721 tcctggtata tttataatag taatgctaat atcaataaaa atcagcaagt aatgttgcct
    33781 atgtatacta ataatacaaa gtcgttatcg ttagatttga cgccacatac ttacgctgtt
    33841 gttaaagaaa atccaaataa tttacatatt ttattgaaca attacaggac agataagaca
    33901 gctatgtggg cattatcagg aaattttgat gcatcaaaaa gttggaagaa agaagaatta
    33961 gagttagcga actggataag caaaaattat tccatcaatc ctgtagataa tgactttagg
    34021 acaacaacac ttacattaaa agggcatact ggtcataaac ctcagataaa tataagtggc
    34081 gataaaaatc attatactta tacagaaaat tgggatgaga atacccatgt ttataccatt
    34141 acggttaatc ataatggaat ggtagagatg tctataaata ctgaagggac aggcccagtc
    34201 cctttcccaa caccagataa atttaatgat ggtaatttga atatagcata tgcaaaacca
    34261 acaacacaaa gttctgtaga ttacaatgga gaccctaata gagctgtgga tggtaacaga
    34321 aatggtaatt ttaactctgg ttcggtaaca cacactaggg cagataatcc ttcttggtgg
    34381 gaagtcgatt tgaaaaaaat ggataaagtt gggcttgtta aaatttataa tcgcacagat
    34441 gctgagactc aacgtctatc taattttgat gtgattctat atgacaataa tagaaacgaa
    34501 gttgctaaga aacatgttaa taatttgtcg ggtgaatctg ttagtctaga tttcaaagaa
    34561 aaaggagcaa ggtatattaa agttaaatta ctaacgagtg gagtgccttt gagtttagca
    34621 gaagtagagg tttttagaga atcagatggt aagcaatctg aagaggatat agataaaata
    34681 acagaagata aagtagtctc tacaaataag gtagctactc aaagttcaac caattatgag
    34741 ggtgtagctg ctttagcagt tgatggtaat aaagatggag attacggaca tcattcggtg
    34801 actcatacta aggcagattc taacgcttgg tggcaggtcg atctgggaga agagtttacg
    34861 gtttctaaag ttgatattta taatagaaca gatgccgaac ctcagcgttt atctaatttt
    34921 gatgttattt ttctatcttc atcaggagaa gaagttttta gaagacattt tgataaagta
    34981 gttgatggtt tgttatcttt aaaagtacct tctgtagggg ctaagctagt caaaatagaa
    35041 ttaaaatcag cagctattcc gttaagttta gcggaagttg aagtctatgg ttcaaagaga
    35101 actccgaaga aactttctaa tattgcatta accaaagaaa ctcgacagag ttcaacggat
    35161 tacaatggtt tttctcgtct agcagttgat ggaaataaaa acggagatta tggtcatcat
    35221 tcagtgactc ataccaaagg agattctcct tcatggtggg agatagattt agcacaaacc
    35281 gaagaattag aaaagttaat tatttataat agaacagatg ctgaaattca gagattatca
    35341 aattttgata ttattatata tgattcaaat aatcatgaag tttttaaaca acatattgac
    35401 agtttagaaa gcaataatct atccatagac ttaaaagggc tgaagggaaa aaaggttaga
    35461 atttctttga gaaacgcagg aattccttta agtttggcag aggtagaggt ttatacttat
    35521 aagtaatttt aaaaattatc atcggtagta tgaaagaaac agaaaaataa gaggaaaata
    35581 gtatgattca acatccacgt attgggattc gtccgactat tgatggtcgt cgtcaaggtg
    35641 tacgcgaatc acttgaagta caaacaatga acatggctaa aagtgtggca gatttgattt
    35701 caagcacatt gaaatatcca gatggggaac ctgtggaatg tgtgatttct ccatctacca
    35761 ttggtcgtgt tccagaggct gcagcttccc atgagttgtt caaaaaatca aatgtttgcg
    35821 caacaattac agttacacca tgctggtgtt atggtagtga aactatggat atgtctccag
    35881 atattcctca tgctatttgg ggatttaatg ggacagaacg cccaggagct gtctatcttg
    35941 cagctgtact agcttcacat gctcaaaaag ggattccagc ctttgggatt tatggtagag
    36001 atgttcagga agctaatgat acagatattc cagaagatgt caaagaaaaa cttttacgtt
    36061 atgcgcgtgc agctcttgca actggcttga tgagagacac tgcttaccta tcaatgggta
    36121 gtgtttcgat ggggattggc ggttctattg taaatccaga tttcttccaa gaatacttag
    36181 gaatgcgaaa tgaatcggta gatatgacgg agttcacgcg ccgtatggac cgtggtattt
    36241 atgacccaga agagtttgaa cgtgcgctca aatgggtgaa agaaaacgta aaagaaggat
    36301 tcgaccataa ccgtgaagac cttgttttaa gccgtgaaga aaaagataga caatgggaat
    36361 ttgttattaa gatgttcatg attggacgtg acttaatggt tggtaaccca agacttgctg
    36421 aacttggttt tgaggaagaa gcagttggtc accatgcttt agtagctggt ttccaaggtc
    36481 aacgtcagtg gacagaccat tttccaaatg gagattttat ggaaactttc ctcaatactc
    36541 agtttgactg gaatggtatt cgaaaaccat ttgtatttgc gacagagaat gattcactaa
    36601 atggtgtgtc tatgctcttt aattatctat taacaaatac tccacaaata tttgctgatg
    36661 tgcgtactta ttggagtcca gaggctgtta aacgtgtaac gggacatact ttagagggtc
    36721 gtgctgcagc tggcttctta catctaatca actctggttc ttgtacattg gatggtacag
    36781 gtcaagctac tcgagatggc aaacctgtta tgaaaccatt ctgggagttg gaagaaagtg
    36841 aagtgcaggc tatgcttgaa aatacagact tcccaccagc aaaccgcgaa tacttccgtg
    36901 gaggaggatt ctcaactcgt ttcttgacga agggggatat gccagtaaca atggtacgtc
    36961 tcaatcttct aaaaggggtt ggtccagtgc tacaaattgc agaaggttat acacttgaac
    37021 ttcctgaaga tgttcaccat actttagata atcgtacaga tccaggatgg ccaactactt
    37081 ggtttgctcc acgtttgaca ggaaaaggtg ctttcaagtc tgtctatgac gtcatgaata
    37141 attggggagc taatcacgga gccataacat atggacacat tggagcagac ttgattacct
    37201 tggcttctat gttgagaatt cctgtcaata tgcataatgt acccgaggaa gatatcttta
    37261 gacctaaaaa ttggtcctta tttggaacag aagatctaga atcagcagac tatcgtgcat
    37321 gtcagttgtt gggaccgcta cataaataaa aattgtgtat ataggaggtg aacttatgtc
    37381 cctcctatcc ttttaaaaag atttgttaaa caattcacaa ataattgaaa acgaatacaa
    37441 aaactaatat aatgatgtta aatagatagc gcggaggcgc aggaggaaaa ttatatggct
    37501 acattttatg ttccggcagt caaccttatt ggtaaaggtg ttgtaaatga agtgggtcct
    37561 tatatcaagg aacttggcta taaaaaggca cttttggtga cagataagta catcgaaggc
    37621 agtgacattt tacctaaggt tttaaaacca ctggatacag aaggaatcga atatgtcatc
    37681 tttagcgatg tagagccaaa ccctacttgt aaaaatgtca cagatggggt agctgctttg
    37741 caagaacatg gctgtgactt tatcatcagt cttggcgggg gttctccaca ggatgcagct
    37801 agttgtattt ctatcatggc tacaaatggt ggaaaaccac aggattatga agggcttcat
    37861 aagtctgcta aaaaaggctt gccagttgtg gctatcaata caacggcagg aacttctgca
    37921 gaaatcacta ttaactatgt gattactgat gaagaacgca aggttaagat ggtaatggtt
    37981 gacaagaata gccttgctct tatctctgtt aatgacccgg aactcatgct ttccaaacct
    38041 aaaggcctga ctgctgctac tggtatggat gctctgactc acgctgttga agctttggta
    38101 acacctggtg cttatgatgt aaccaagaaa ctgtctattg gtgctattga gcttatcaag
    38161 gaatatcttc ctcgtgctgt agaaaatgga catgatattg aagcgcgtga aggtatggtc
    38221 aatgccatct tccttggtgg tatgagcttt aataatgctg gtcttggtta tgttcactca
    38281 atggctcacc aactcggtgc agtatataat ttgccacatg gtgtttgctg tgccatgttg
    38341 ctaccagtta tagaacgtga aaatgctaaa cgtgtaccag aagctttccg caatgttgcc
    38401 aaagccttgg gacttcatgt agaaggtaaa tcagatcaag aatgtgccga ttatgcgatt
    38461 gttgagattg agaagctttc tgagacagta ggtattccta agaaactgac tgaacttggt
    38521 attgaagaaa aagatttcga ctttgaatac ctttctaaga atgccttgat tgatgcctgc
    38581 gcaccaggaa atccatttat gccaacctta gaagaaacga ttgcctttta taaagagtta
    38641 ttttagcaag agattggacg acaataggac aattcacctc taattattga catttcagga
    38701 aaaatcgcag taaaaacggc acagccttct ttaaatgtgc tataatacta gaaaaatact
    38761 tgtggaggtt ccattatggc aatatttttc atgatttttc tgattgtttg tgtgctccta
    38821 ttggtgatag tcacactgag tacagtttat gtggttcgtc agcagtcggt ggcgattatt
    38881 gaacgctttg ggaaatacca aaaggttgct aatagcggta ttcatattcg cttgcctttt
    38941 gggattgact cgattgcagc acggattcag ttgcgcttgt tgcaaagtga tattgtggtt
    39001 gagactaaga ccaaggacaa tgtgttcgtt atgatgaatg tagcgactca gtaccgtgtc
    39061 aacgagcaga gcgtgacaga tgcttactat aaactcatac gtccagaatc tcagattaaa
    39121 tcttatatcg aagatgctct tcgctcttct gttccaaaat taaccttgga tgaattgttt
    39181 gagaaaaaag atgagattgc ccttgaagtt caacaccaag tagcagaaga aatgaccact
    39241 tacggctaca ttatcgtgaa aaccttgatt accaaagtcg aaccggatgc agaagttaag
    39301 caatccatga atgaaatcaa tgcggcgcaa cgtaagcggg tcgcagcaca agaattggcg
    39361 gaagctgaca agattaaaat tgtcactgca gctgaagcag aagcagaaaa agaccgcctt
    39421 catggtgtgg ggattgccca acaacgtaag gcgattgtgg atggattggc agagtctatc
    39481 accgaactca aggaagccaa tgttggcatg acagaagaac aaatcatgtc tatcctcttg
    39541 accaaccagt atttggatac cttgaatacc tttgcctcta aaggaaatca aaccatcttt
    39601 ttaccaaata ctccaaatgg tgtggatgat atccgaacac aaatcttgtc agcccttcgc
    39661 gctgagaaga aataatagac taatactctt cgaaaatctc ttcaaaccac gtcagcgtcg
    39721 ccttgccgta tagatgttac tgacgaagtc agttctatct gcaacctcaa aacagtgttt
    39781 tgagctgact tcgtcagtct tatctactac ctcaaaacgg tgttttgagc aacctgtggc
    39841 tagtttccta gtttgctatt tgattttcat tgagtacaaa gagcttggca acaggctctt
    39901 tttgtattgc gtttattaag aaaaacaaaa aacatcgata tacatttaac taaaaattat
    39961 tgtatgttat ctcccttaat taggaatgat aagggaataa ctagaaagat ttgtgaatac
    40021 aaactatttc tgatatacaa aatatacagt aataatgaat gatgggagat gggatgaaag
    40081 aatttcaatt tgagagaaag cagcgttttt ctttgaggaa atatgcaata ggagcttgtt
    40141 cggtcttgct aggaacgagt ttattttttg ctggtatggg tgctcagcct gtacaggcta
    40201 cagaaacgag ttcagcacta atttcaagtc attatttgga tgagcaggat ttatctgaaa
    40261 agctgaaatc tgagttgcaa tggcttgaat tagaaaacaa gcttttgaac ttatgggagc
    40321 attaggttac tatgaaggat ttgttcctta cgtttcaaat taatacaaaa accaagctga
    40381 agaagacaaa ccgctatctg ataaatatat tttcgaaaaa atcttaggaa aaacatatgc
    40441 agccttcaaa aaagatcaaa ttaatgagcg tgtcgagaaa ttaggtaagt taaaacctat
    40501 tacaataaat tacaacggaa aatcagaagt aattgatagt aaagaaaaat tacaagagct
    40561 tatgaataaa gccgttaaag acgaagtggc tcaaatatag taaaatgaaa taagaacagg
    40621 acaaatcgtt caggacagtc aaatcgattt ctaaaaatgt tttagaagta gaggtgtact
    40681 attctagttt caatatacta taaaatcagg caataccacg gctaaaaagt ttgagtttat
    40741 cgaaacacca gtgcaaaaac tgaaaaaagc gatttataaa gctcatctca aagattcaga
    40801 tgactttaga ccagaaacat ccacacaaat ctttttgaaa gctgtttgaa gctttgtcct
    40861 tgctttctta gttcatagat ctgaacttta tcttcataac tcaatttcat aataaaacac
    40921 cccaaaagtt agatttattc tgtctaactt ttggggtgca gttcattaat cggtcgattt
    40981 tttttggtag aaacagttgc ctgattaagt tgcaagtcga tagacggctt cggcataaat
    41041 atccatagca cggtacaaat cttctagaac ggcacattca tttgcctgat gttctgtctg
    41101 cttcgctcct gggaataagg cgccgaaggc tacacaattt ggcatggtgc gagcaaaagt
    41161 ggcaccaccg gatgaaatag caggactgtt atcgccagtc ttttcttggt agatttgcat
    41221 cagtgtgcta acgagtttac tgtcttttgc gacgtataga ggcgctagat agtcaaactc
    41281 ttcgtagcgg agttggtagt tttgtgcaca tcttgtaagc aactctacta gttcttcctt
    41341 gtcagctaag acaggagtcc gaatgtcaat acggatttca gaacgttcat gattgatcat
    41401 gagacctgcg acattaaagg ataggtgacc agaaggttca tctgctatat caccaaagat
    41461 ttgtcttcct gtgccgtctt gacctgcttg tgttgcaaga aagctgagag cagggtgttc
    41521 ttggagagga gcaagaatgg tagctagtcg gatgacagca ttgatacctt gactagcatc
    41581 cttagcatgc tttggcactc cgagaaccgt tacggtttgt tcagtggatt ggtaatcata
    41641 accagcttct ttgagatcgt tacaaacctg ttcatagagg ggaccttggt agttggcctt
    41701 gcctggtaca acgttaaagg cgcctcctac ttcaagctct agttgatccg atccagggcc
    41761 atgaagtttg acctgtagaa gccctttttc agcataggtc agaggaaaag atgagtcagg
    41821 tgcaaagccc atactggcct gttcttcgat ggtattgtag cgtgccatgc agcgccagag
    41881 ggtttcctca tcggtaccaa agataaagcg tacgcgcttt ttgaactgaa taccttggtc
    41941 cagcaagctt tttactgcat agagagctgc gagcgaaggg cctttatcat cttggacacc
    42001 acgtccgaat acccagccgt ctttgatagt tgcttcaaat ggcggtgtct gccaatctgc
    42061 ttcatcacct gatggaacaa catccaaatg acagagaatg gccagaagct ctgctccctg
    42121 accgatttct gcatatccgt aataaccttt agggtcaaga taggtagtga aacctatgtc
    42181 tcgacaaatc tctaaagttt tttctaggac atcttggatt gcttgtccaa aaggtgttcc
    42241 attttctcct tcattgagta ctgaaggata ggaaatcaag gtttttaatg atataagaaa
    42301 ttcatcttta acttgatttg ttatatctat tttcatggaa tcacctcact cactatttta
    42361 taggaatgga aggaaggttc caaggagaag aagggcgatg gtcactacaa taatagcgac
    42421 tacgagtttg cccatgaatt tccaccaagt accaatgttg atacgtccaa gtgcaagagc
    42481 tcccatcaca ataccagatg ttggtgcaat caagttcaag acacctgaag cagattggta
    42541 agcagtgata atcaagctag gacggacatt tacaaattct ccaagtggag ccatgatacc
    42601 catagttgcg ctggcaagac cagatgaaga tgggatcaag aatgacatag gtagatagaa
    42661 gatataagtt acaacgataa agacttgtga agatagaccg ctcaagcctt ctttacccca
    42721 gttgaggatt gtatcggtaa tcataccgtc gttcatgata acttgaatac cacgagcaat
    42781 cgctacgatc aaggcaacac tgagcaagtc agcagcacca ttcatgaagg aagagataat
    42841 cttatcttct ttaagaccat aaataacacc aatcaggata cccataaagg caaagagcat
    42901 tgcgccttct gggaagtacc aagtacctag tgcagaagta gatgaaccga caatattacc
    42961 aataactgga agaccagtca accaagcatt aaagtcatca aaaatggtaa cgccaaggtc
    43021 tgtccatgga atgaagctca ataccatcaa gatgaatgtc aacacaaata agaagagaac
    43081 tgatttttgt ttgctgctaa gtgtagattc tacagatgaa gattcttcta cgttaaagtg
    43141 tttcaaatct tctttgcgag tactataaac cagtgactta gtcggatctt tttgaatctt
    43201 atccgcataa cggtaaacaa accaagtact aagagcagtc aaggtaaccc agaagatcag
    43261 acgaagtacg ataccgtccc ctgtaccaac tcccgcagtc gctgaagcaa tacctgtcgc
    43321 aaatggattc agagtagatg ccaaacagcc gatttgagaa ccgagcaaaa taattgcaac
    43381 accagtcagg ctatcaaaac caacggccat cataactggc acaaggagtg gatagaaggc
    43441 cattgtttct tcacccatac cataagttgt accaccgagg gcaaacaaag gcatcagtac
    43501 caaaattaac attttttcgc ggcccttata cttcttcacg atagaggcaa tccctacgtc
    43561 aagagcacca gttttgttga caatgccaag gaaaccacca accataagga tgaagaaggc
    43621 tacatcaatc gctgcgctcg tttctttaat gagcgaacct tcctctggat gagtacctag
    43681 catagcccga atcggtgcca tgaggacatc ccaaatccct tgtggatttt gaggctgagt
    43741 ctcgtaaata ccttctataa aggcccccgc agggataaac caagttagca ctgccataat
    43801 agcaatgatt atcaataata cggtgtaaga tgaaggcatc ttaaaccctt ttttagcttt
    43861 ttcactcatt tgtttttcct cctgatgtct aacaaagtgt aaaaaaccaa ctactttctt
    43921 aaataaacat tcaagaaaac gctttctatt tatatttgtt ttaccatatt aaagtctaaa
    43981 actagtatct tttgaaatat tgtacatgtt ttcaagaata atttctaatt tgatataaag
    44041 atactagaaa tagaatacat cttattagta aaacaactta tcctttttca ataattgttc
    44101 cgctttcaga ttcaatcaag gcgcctagat tttcaaggga agtaataact gcttttcctt
    44161 ctggacgacc attgacaaaa gcgatagctg cttctacttt tggaagcatg ctacctggtg
    44221 caaactgatc ttgtttgata tattcttcca gctgggcaac attcacatgt tccaattttt
    44281 cctggtttgg cttgttgtag ttaacaaata cataatctac acctgtcaaa acgatgaaga
    44341 ggtctgcatc aaccaattct gccaaacgtt gggaagcgaa gtctttatca ataaccgctt
    44401 cgacaccagt caaatgtcca ttgttttctt tgacgacggg aataccgcca ccacctgcag
    44461 ctacgacgac ttgaccatta tttaaaagag tacggatggt ttcaatttct ttgatgtcaa
    44521 caggttttgg tgaggcaacg accttacgcc agccacggcc agcatcttcc ttgaaagtcg
    44581 ctccgctctt ttcggcttct gcttttgctt cttcttctga atagaaagga ccgattggtt
    44641 tactcaagtt aacaaaagct ggatcatttt tatctacgac aacttgcgtt acaacagagg
    44701 caacattttt ttcgatgcct tcatccaaga gagcattttg caaagcattt ttcaaccaga
    44761 aaccgatgct accttctgtc atagcgacaa gtgagtcgag tgggaaggca gggttctttt
    44821 cagagtctga tgccaaatgt tggagcaaga gattcccaac ttgaggtcca ttaccgtgag
    44881 tgataatcaa atcatctcca tttttaatca attttacaag atgcttagct gtttcaacta
    44941 aagcttcttg ttgagccttt gctgatgggt cagaagaaag aatcgcattt cctcccaaag
    45001 ctactacaat tttacgattt gccataaatt ctcctttatc acactcaata gaatgcgttt
    45061 agatttcaat ttaatgattt ttcacatatt ttataagaaa taatagatta ccattatata
    45121 aaagaggacc ggactaaagc tattagtcgc agccctcata gctgttggta gacggtttat
    45181 tatctaaaat tatactttag gaatataaag gttaccaagt gtagcagcca taacagcttt
    45241 gatagtgtgc atacggtttt ctgcttgatc gaagtggcga gcgtacttgc tgcggaagac
    45301 ttcgtctgtt acttccattt cttctacacc aaatttttca gcaacgtctt taccataaac
    45361 agtgtgagta tcgtggaatg ctggcaagca gtgtaggaag atcaagtttt cattgcctgc
    45421 ttttttaact aagtccatat tgacttggta aggtttaaga agagctacac gttctgcgaa
    45481 tttgtcttct tcacccattg atacccaaac gtctgtgtaa agaacgtctg catctttaac
    45541 tgcttcatca gcatcttcag tgatgagaac atgtgcgcca ctttctttag caaatccttc
    45601 tgccaattca acgatttctt tttctgggaa gagttctttt ggtgagaaga tgtgaacatt
    45661 gacaccaagg atagcacctg ttacgagcaa gctgttggca acgttgttac gtccatcacc
    45721 acagtatacc aatgtcaagc cttccaagcg accgaagttt tcttgaacag tcaagtagtc
    45781 agcgagcatt tgagttgggt gccattcgtc agttagaccg ttccatactg gaacgcctga
    45841 gaattctgcc aattcttcaa ccatacgttg gctgaatccg cggaattcaa tcccgtcaaa
    45901 catacgtccc aatactttag cagtatcttc agtagattct tttttaccca actgaatatc
    45961 atttgctccg aggtattctg ggtgagcacc aaggtcgata gccgcagttg taaaggctgc
    46021 acgagtacga gtagatgttt tttcaaatag gagagcgata ttcttgccag caaggtagtg
    46081 gtgttgaata ttgcgttttt tcaaatcttt caagtgagct gaaagaccaa taaggtattc
    46141 taactctgca cgggtaaagt ctttttctgc taagaagctg cgtccttgga atactgaatt
    46201 tgtcatttta ttatttcctc tttctatttt ttacattttc tattgacgaa taccgaacag
    46261 cgattacact tcttcacgtt caaatggcat agacatacaa cgaggtccac cacggccccg
    46321 aaccaattca cttccgcgaa tcttaatcaa gcgaagcccg tattcttcca aaatcttatt
    46381 ggtcacggta ttgcggtcat aaacaactac cacaccaggt gcgatggtca aagtgttaga
    46441 accgtcgttc cattgttcac gcgcagctgc tacgatattg ccaccaccgc aacgaatcaa
    46501 atgaactttt tctacaccaa ggttttgagc aagaagttca gctaagtcac ctttctcttc
    46561 aacgatttta agtttttcgt tttcgtaagt aactgagtaa acgtgaaggt cgccttcgat
    46621 ttctgggtga atagtgaact tgtcatagtc taccatagtg aagacagtat ccaagtgcat
    46681 gaatttacgg ttgttagcaa attcaaaggc caaaactttc ttgaagccaa catttttctt
    46741 gaagatgttg accaaaagtt tttcgataga agctgcgtct gtacgttgag agatacctac
    46801 tgcaaggacg tctttagaaa gaactagctc gtctccacct tcgatacgcg tatcttcttc
    46861 acggttgtag accaaatcca cttttccgcc atagattggg tggtatttga agatatactt
    46921 accgtagagt gtttcacggt tacgagtgtc tgcaaacatg tggttaagcg atacggcgtt
    46981 tccaattgtt gcaaatgggt cgcgagtgaa atagaggttt ggcatcgggt caattgcaaa
    47041 tggataatct gattcaacta agtcagttag atctttagat tcgtcaggaa tttctggcaa
    47101 ttcaactttt tgaatcccag ccattgtttt ttcaaccaat tcttggttgt ccttgatgcc
    47161 gtgaagcaat tcacgaatag caaccttggt ttgacgatca cggatgttgg cttcgtctaa
    47221 gtattcctcg ataaattgat cgcggatttc tggagaggtc aatgattcag cagcgagttg
    47281 ttctaggtag agaacctcaa ttccttcatc gcgaagagct tgggcaaatg catcatgttc
    47341 tttttgagca tcttccaaga aaggaatatc atcaaaaaga agcctttcaa gatagtccgg
    47401 caacaagttt tctaactcct tgcctggacg gtgcaacata acttttttca gtttcccaat
    47461 ttctgagaag acctgaattg gatgtgaaga catgtatttt cctccttaaa aattttgact
    47521 tggcaccatt ttgggtaccg cttacatgta tgttataacg caattcctag gtaatgtcaa
    47581 tggctataat ttctcggaaa ataatataaa ttatgatgtt tagcacaatt ttatgttatt
    47641 atacataaca taggatagaa tacatagata caaatgcata aacttctata aaaaggatat
    47701 aaaatttttt taaaaaattt ttcaaaaaat atacaaatga ccaaaaagtg tccaattatc
    47761 atctggttat cacttggatc tgtataaaga gaaatgtttg tgtgaaagga taaaaagatg
    47821 caacattctt ttgaagatag attttggaga agcatttctt gttcaattgt acaaattata
    47881 gaatcttttc tgagtattta ggaagagata attatcttat tgaccctctt tttatttttt
    47941 gttatagtcg acgaggtgat agtttagaat aatcacttat tcacaatctg tggaaaagtc
    48001 tggagagtga atggtcttca cacaatgacc tgaaagaagc ctgagaataa ttatggagag
    48061 tagcattctg agaggtgtta gcagaaccat atgacagagc tgtttgaaga gggaatattg
    48121 aggagcaaaa tcctgagcct accagttgga gttggaaaga gctggctgtt agatcatggt
    48181 ttattatcca caacctgtgg ataaccttgt gaacaagaga agttgctaaa gaaggagata
    48241 tataacgatg aagaaaatca aaccgcatgg accgttacca agtcagactc agctagctta
    48301 tctgggagat gaactagcag cttttatcca cttcggtcct aatacttttt atgaccaaga
    48361 atgggggact ggacaggagg atcctgagcg ctttaacccg agtcagttgg atgcgcgtga
    48421 gtgggttcgt gtgctcaagg aaacgggctt caaaaagttg attttggtgg tcaagcacca
    48481 cgatggcttt gtcctttatc cgacagctca cacagattat tcggttaagg tcagtccttg
    48541 gaggagagga aagggcgact tgctccttga agtatcccaa gctgccacag agtttgatat
    48601 ggatatgggg gtctacctgt caccgtggga tgcccatagt cccctctatc atgtggaccg
    48661 agaagcggac tacaatgcct attatctggc tcagttgaag gaaatcttat caaatcctaa
    48721 ctatgggaat gctggtaagt tcgctgaggt ttggatggat ggtgccagag gagagggcgc
    48781 gcaaaaggtt aattatgaat ttgaaaaatg gtttgaaacc attcgtgacc tgcagggcga
    48841 ttgcttgatt ttttcaacag aaggcaccag tatccgctgg attggcaatg aacgagggta
    48901 tgcaggtgat ccactgtggc aaaaggtgaa tcctgataaa ctaggaacag aagcagagct
    48961 gaactatctt cagcacgggg atccctcggg cacgattttt tcaatcggag aggcagatgt
    49021 ttccatccgt ccaggctggt tctaccatga ggatcaggat cctaagtctc tcgaggagtt
    49081 ggtcgaaatc tactttcact cagtagggcg aggaactcca ctcttgctta atattccgcc
    49141 gaatcaagct gggctctttg atgcaaagga tattgaacga ctttatgaat ttgcgaccta
    49201 tcgcaatgag ctctataaag aagatttggc tctgggagct gaggtatctg gtccagctct
    49261 ttccgcagac tttgcttgtc gccatttgac agacggcctt gagaccagct cttgggcaaa
    49321 cgatgcagac ttgcccatcc agttagaact cgacttaggt tctcctaaaa cttttgatgt
    49381 aattgagttg agagaagatt tgaagttagg ccaacgtatt tctgctttcc atgtgcaagt
    49441 agaggtggat ggtgtctggc aggaatttgg caggggcttc acagttggtc ataagcgcct
    49501 cttgcgaggt tcgctagtag aggcacaaaa ggtgcgcgtg atgattaccg aggcacaatc
    49561 tattcctgta ttgaccaaga tttcccttta taaaactcct ggattatcaa aaaaagaagt
    49621 tgttcaggaa ctagcatttg cagaaaaaag cctagctgtg gcaaagggag aaaatgccta
    49681 ttttacagtt aagcgcagag aatgtagtgg tcctttagaa gctaagattt cgattcaacc
    49741 ggggacaggt gtccatggtg tcgcctatca ggacgagatt tatgtccttc aattccaagc
    49801 aggggaaagc aaaaaagatt tgcatctacc aaccctgtat ttcgcaggag ataaaacctt
    49861 ggatttctat ctgaacctaa cggtggatgg tcagcttgtg gatcaacttc aagtccaagt
    49921 ttcataaaag aagaaccttt gcgcgatgca aaggttcttt tggttattag tgacttggta
    49981 gccagctgag ggtgaaagtt agttgttcag cttttaagag gtcttggtgt tgaatagttg
    50041 atacgagtgt tttgttcagt cggcattctt tgacaaagtt aaaatggttg tggttttgtt
    50101 tagtatggat atccagccat ttatcttctt tagctaggta gactcgtaga tggtcaaaga
    50161 gagggattcc gaggtcatag cttggttttc ctggacaggt tggataaaat ccgagagctg
    50221 accagatgta ccaagcagag agactaccat tgtcttcatc tccaggatag gcttcccaac
    50281 ttgggtgaaa agctttctga cggagcgtct tgataagaag ggcagtgtag tcagggtaat
    50341 cgctgtagcg gaagagataa gggatgtgga aactaggctg gttggaaatg gctatttgtc
    50401 caaaaggagc agtagccatc tcgctcattt cgtgaatttc ataaccatag cctgttgttt
    50461 caaagagggg agcatcttga caggctttca aaagatagtt gctaaaggtt tcttttccac
    50521 ccatcagttg gattaagcca gggatgtcgt ggagaacgcc taaagtagct tgaatggcag
    50581 agcattcagc gtagtctcgc ccccaactat aaggagagaa gtcagggtga aagtttcctt
    50641 gattgtctcg tgctcgcatg taacctgtct cagcgtcaaa tagctggcgg taattttgtg
    50701 aagcagcctt gtaggtttca gcgatttcta tgttctctag ttttttggca cagctggcga
    50761 tacaaaagtc actataggca tagtctagag tatggctaac actttcatgg tggtcggtag
    50821 agaggtaacc tagttcttgg tattgggcta gtccgtggcg gccattgatg ccgagagggt
    50881 cggctttgct ggctgtttcg agcatggctt ggaagagttc tccttctagg tcgggggcca
    50941 tgtccttaca ggcgctatct gcgataatgc catctagcag tgtacctggc atcatacccc
    51001 gttcatctgg agccagccat tttggaagga aaccagtatc gcggtagcta ttgaggaaac
    51061 cttctaaaaa gcgttgatag tgctccggta tgataagggc aaagaggggg aaggtggtgc
    51121 ggaaggtatc ccagaaacca ttgttgctaa agaggacacc aggcttgaca gtaccagtag
    51181 ccagatccat gtggatggct ttccctgact catcaacctc ataaaaagtc tgtgggaaga
    51241 ggaagagtct gtagagacag tggtcaaaga aggttcggtc agcctctcct gtctctataa
    51301 tgtcaaaacg atggaggaga ttttcccaat ccgcttgggc acttgtttta cagctatcaa
    51361 aatcttcttg aggtagattg attagagctt gagaaggaga gatgaaagaa gtggctagtt
    51421 gcatctcggt ttgactactt gctaagtcaa ttcgccagtc tccagcttct tggctgatag
    51481 caagaatatc cgtgttcatt tgcagggcag tgaacatcgt tagcgaattt ttgttagttt
    51541 cagttttacc ttcttgtcgc agggcaagag tccgcttatc tacttgctct actgtcagtt
    51601 catctgctgc gtgaagatag agggagaggg ctttgccttg cttttgattc aaacgaatag
    51661 aagcaccata gcaagtcggt gtgagctggg tttcaatctg ataacgcaga gaaaagagct
    51721 tcaaatagtg aggctggaag caagctttat ctatatcata agaagactgg cggtgaaaga
    51781 ggctgtctcc ccccagttga ctggtgacag gtgtcagaag gagccaagag tagtccccaa
    51841 tccaaggact gggctggtga gttaatcgaa tcccctgaaa gataggcaga tgcggatcaa
    51901 aaaaccaaga tccatcctgg tcactggtct ggggcacaaa gtaattcata ccaaaaggca
    51961 cgcctgtgta tggcagggta tttccccgag agaaggcatg cttgctagca gtaccaaagc
    52021 gggtatcgat ggtttcaagt agtggtttca tagtctttcc tttagctgtt tttctacatt
    52081 atatcagaaa aagagggcct ttagaaaagg agtttcaaaa ataactattt tgtagaaaaa
    52141 tgactatcat ttgtgtatgt attttctgtc tcaaaagcta tatactgaac atgaaacttg
    52201 tttgaaagag ggaattgcac gatgatttat tcgaaagaaa ttgttagaga atggctagat
    52261 gaagtagcag agcgggccaa ggaccatcca gagtgggtgg atgttttcga gcgttgctac
    52321 accgatacct tggacaatac ggttgaaatc ttagaagatg gttcaacttt tgtcttgact
    52381 ggggatattc ctgctatgtg gcttcgggat tcgacagccc aactcagacc ctacctgcat
    52441 gtggctaaaa gagattccct cctgcgtcag accattgcag gtttggtcaa acgtcagatg
    52501 accttggtac tcaaggatcc ctatgctaac tccttcaaca ttgaggagaa ctggaaaggg
    52561 caccacgaga ctgaccacac agaccttaac ggctggatct gggagcgcaa gtatgaggtg
    52621 gattcgcttt gctatccttt gcagttggct tatctcctct ggaaagagac tggcgagact
    52681 agtcagtttg atgagatttt tgtcgcagcg actaaggaaa ttctccatct gtggacggta
    52741 gaacaagatc ataagaactc tccttatcgt tttgtccgag atacggaccg caaggaagac
    52801 accttggtaa atgatggctt tggacctgat tttgcagtga caggaatgac ttggtcagcc
    52861 tttcgtccga gcgatgactg ctgtcagtat agttacttga ttccgtcaaa tatgtttgct
    52921 gtagtagtct tgggttatgt gcaagaaatc ttcgcagcat taaacctagc tgatagccag
    52981 agtgttattg ctgatgccaa gcgtcttcag gatgaaatcc aagaaggaat cgaaaactac
    53041 gcttacacca ccaacagcaa gggcgaaaag atttacgctt ttgaagtgga tggcctagga
    53101 aatgccagca tcatggatga tccaaatgta ccaagtctac tagctgcgcc ctatctgggc
    53161 tactgttcgg tcgatgatga agtgtatcaa gctactcgtc gtaccatttt gagctctgaa
    53221 aatccatatt tctaccaagg agaatacgct agcggtctcg gaagttctca taccttctat
    53281 cgctatatct ggccaatcgc cctttctatc caaggattga caacaagaga taaggcagag
    53341 aaaaaattct tgctggatca gctggttgcc tgcgatggtg gtacaggtgt catgcacgaa
    53401 agcttccacg tagatgatcc gaccctctac tctcgtgaat ggttctcctg ggctaacatg
    53461 atgttctgtg agttggtctt ggattattta gatattcgct aaggggctcg ctttagctca
    53521 accgattctt atcagaatca caagtttaca tttaaaacgt taaaatttaa atttagaatg
    53581 aggttttact tcatggaaaa tgttgttgta catattatct cacatagcca ctgggaccgt
    53641 gagtggtact tgccttttga aagccatcgt atgcagttgg tggaattgtt tgacaatctc
    53701 tttgaactct ttgaaaatga ccctgagttc aagagtttcc acttggatgg acaaactatt
    53761 gtccttgacg actacttaca aattcgccct gaaaatcgcg acaaggtcca acgctacatt
    53821 gacgagggca aacttaaaat tggtcccttt tacatcttgc aggatgacta cttgatctcc
    53881 agtgaagcca atgtccgcaa taccttgatt ggtcaacaag aagctgccaa atggggtaaa
    53941 tcaacccaga ttggctactt tccagatacc tttggaaata tgggacaagc gcctcaaatt
    54001 cttcaaaaat caggcattca cgtggcggcc tttggtcgtg gtgtgaagcc gattggattt
    54061 gacaaccaag tccttgaaga tgagcagttt acatcccagt tttcagaaat gtactggcag
    54121 ggtgtggatg gtagtcgtgt tttaggtatt ctctttgcta actggtacag taatgggaat
    54181 gaaatcccag ttgacaaaga tgaggccttg accttctgga aacaaaaatt gtcagatgtg
    54241 cgtgcctacg cttcgaccaa ccaatggttg atgatgaacg gctgtgacca ccagcctgta
    54301 cagaaaaatc tgagcgaagc cattcgtgtg gcaaatgaac tcttcccaga tgtaatcttt
    54361 gttcatagtt cttttgatga atatgttcaa gctgtagaag gtgcgcttcc tgaacactta
    54421 tcaactgtta caggcgagtt gaccagtcag gaaacagatg gctggtacac acttgccaac
    54481 acttcttcat cccgcattta cctaaaacaa gccttccaag aaaatagcaa cctcctagag
    54541 caagtggtag aacccttgac tattatcact ggtggacaca accacaagga ccagttgacc
    54601 tatgcttgga aaacactttt gcagaatgcg ccacatgata gtatctgtgg ctgtagcgtg
    54661 gacgaagttc accgcgagat ggaaacgcgt tttgccaagg tcaaccaagt aggaaacttt
    54721 gttaaaagta atttgctcaa cgagtggaag ggtaaaattg ctacggataa ggctcaaagt
    54781 gactatctct ttactgtcat taacacaggc ttgcatgata aggtcgatac tgtcagcaca
    54841 gtgattgatg tggcgacttg tgatttcaag gaattgcacc caacagaagg ctacaaaaag
    54901 atggccgctc ttatcttgcc aagttaccgt gtggaggact tggatggtcg tcctgtagag
    54961 gctacaatcg aagacctcgg agctaatttt gaatacgatt taccaaaaga caagttccgc
    55021 caagctcgta ttgctcgaca agtgcgcgtg accattccag ttcagctagc gccgctttct
    55081 tggacaacct tccaattgct ggaaggaaaa caagaacacc gtgagggtat ttaccaaaac
    55141 ggagtgattg atacaccatt cgtaacggtg agtgtggatg acaacatcac agtctatgac
    55201 aagacaactc acgaagccta tgaagacttt atccgctttg aagaccgtgg ggacatcgga
    55261 aacgagtata tctatttcca accaaaagga acagagccaa tctttgcaga gcttaagggc
    55321 cacgaggtct tggaaaacac agcttgctat gctaaaatct tgctcaaaca tgaattgacc
    55381 gtgcctgtca gcgcggatga aaagctagaa gaagagcaac aaggtatcat cgagtttatg
    55441 aagcgtgagg ctggacggtc agaagaattg acaaacattc ctctggaaac tgagttgact
    55501 gtcttcgttg acaatccaca aatccgcttc aagactcgct ttaccaacac tgccaaggat
    55561 caccgtatcc gtctcttggt caagactcat aacacgcgtc caagtaatga ttctgaaagt
    55621 atctatgagg tggtgacacg accaaacaaa ccagctgctt catgggaaaa tcctgaaaat
    55681 cctcaacacc aacaagcttt tgtcagtctg tatgacgatg aaaaaggggt gactgtatcc
    55741 aataagggat tgaatgaata cgaaatcctt ggggataaca ccattgccgt gaccattttg
    55801 cgtgcatcag gtgagctagg tgactggggc tacttcccaa cgccagaagc acaatgcttg
    55861 cgggagtttg aagtcgagtt tgcacttgaa tgccaccaag cccaagaacg cttctcagcc
    55921 tatcgtcgtg ccaaagcctt gcagacatcg tttaccagcc ttcagcttgc tagacaggaa
    55981 ggaagcgtgg ttgcgattgg tagcctcttg agccattctg ttctcagcat accgcaagtt
    56041 tgtccaacag cctttaaagt ggcggaaaat gaagaaggct atgtcctccg ttactataat
    56101 atgagtcaag aaaatgtgcg catatcagaa catcaacaaa ccattcttga cttacttgag
    56161 cgaccatatc cagttcattc aggactattg gctccacaag agattcgtac agaattcatc
    56221 aaaaaagaag aaatttaatt tcaaaaagta aacatcaaaa gaaaggaggg gcgaaaaggt
    56281 aagaactaac tgctgatttg ccccttttta tggtaaaaaa atgaccattg caacgattga
    56341 tatcggaggg actgggatta agtttgctag tctgactcct gatgggaaaa tactagataa
    56401 gacaagtatc ccaacaccaa aaaacttgga ggacttacta gcttggctag atcaacgttt
    56461 gtcagaacag gattatagtg ggattgctat gagcgttcca ggtgcggtca atcaagagac
    56521 aggtgtgatt gatggcttca gtgcggtgcc ctacatccat tgcttttctt ggtatgaggc
    56581 gcttagctct tatcagctac ctgtccattt agaaaatgat gccaactgcg ttggactcag
    56641 tgaactacta gctcatccag agcttgaaaa tgcagcctgt gtcgtgattg ggacagggat
    56701 tggcggagcc atgattatca atggtagact tcatcgaggt cgccacggtc tgggtggaga
    56761 atttggctac atgacaaccc ttgcccctgc tggaaaactt aataactggt cgcaactagc
    56821 atcaactggg aatatggtac gatacgtaat tgaaaaatct ggtcatactg attgggacgg
    56881 tcgcaagatt taccaagagg ccgcagctgg taatgctctt tgtcaagaag ccattgagcg
    56941 catgaactgc aatctggcgc aaggcttgct caatatccag tatctgatcg atccagatgt
    57001 catcagtctg ggtggctcta tcagtcaaaa tccagatttt atccaaggtg ttaagaaggc
    57061 tgttgaagac tttgtagatg cctacgaaga atacacggtc gcaccagtta tccaggcctg
    57121 cacctatcac gcagatgcca atctctacgg tgctcttgtc aactggctac aggaggaaaa
    57181 gcaatggtaa gatttacagg acttagtccc aaacaaacgc aagctattga ggttttaaaa
    57241 ggtcacattt ctctaccaga tgtggaagtg gctgtcactc agtctgacca agcctctatc
    57301 tctatccagg gtgaggaagg tcactatcaa ttgacctacc gcaaacctca ccaactttat
    57361 cgtgccttat ccttgttggt aacagttcta gcagaagctg ataaagtaga gattgaggaa
    57421 caagcagctt acgaagattt ggcttacatg gttgactgtt ctcgaaatgc ggtgctgaat
    57481 gtggcttctg ccaagcagat gattgaggtc ttggctctca tgggctactc aacctttgag
    57541 ctttacatgg aagacactta ccagattgaa ggacagcctt actttggcta tttccgtgga
    57601 gcttattcag cagaggagtt gcaggaaata gaagcctatg ctcaacagtt tgacatgacc
    57661 tttgtaccat gcatccagac cttggcccac ttgtcggcct ttgtcaaatg gggtgtcaag
    57721 gaagtgcagg agctccgtga tgtagaggac attcttctca ttggcgaaga aaaggtttat
    57781 gacctgattg atggcatgtt tgccacgttg tctaaactga agactcgcaa ggtcaatatc
    57841 gggatggacg aagcccactt ggttggtttg ggacgctacc tgattttgaa cggtgttgtg
    57901 gatcgtagtc tcctcatgtg ccaacacttg gagcgcgtgc tggatattgc tgacaaatat
    57961 ggtttccact gccagatgtg gagtgatatg ttcttcaaac tcatgtcagc ggatggccag
    58021 tacgaccgtg atgtggaaat tccagaggaa actcgtgtct acctagaccg tctcaaagac
    58081 cgtgtgactc tggtttactg ggattattat caggatagcg aggaaaaata caaccgtaat
    58141 ttccgcaatc atcacaagat tagccatgac cttgcatttg cagggggagc ttggaagtgg
    58201 attggcttta cacctcacaa ccattttagc cgtctagtgg ctatcgaggc taataaagcc
    58261 tgccgtgcca atcagattaa agaagtcatc gtaacgggtt ggggagacaa tggtggtgaa
    58321 actgcccagt tctctatcct accaagcttg caaatctggg cagaactcag ctatcgcaat
    58381 gacctagatg gtttgtctgc gcacttcaag accaatactg gtctaacggt tgaggatttt
    58441 atgcagattg accttgccaa cctcttacca gacctaccag gcaatctcag cggtatcaat
    58501 cccaaccgct atgtttttta tcaggatatt ctttgtccga ttcttgatca acacatgaca
    58561 cctgaacagg acaaaccgca cttcgctcag gctgctgaga cgcttgctaa cattaaagaa
    58621 aaagctggaa actatgccta tctctttgaa actcaggccc agttgaatgc tattttaagt
    58681 agcaaagtag atgtgggacg acgcattcgt caggcctacc aagcggatga taaagaaagt
    58741 ttacaacaaa tcgccagaca agaattacca gaacttagaa gccaaattga agacttccat
    58801 gccctcttta gtcaccaatg gctgaaagaa aacaaggtct ttggtttgga tacagttgac
    58861 atccgtatgg gcggactctt gcaacgcatc aaacgagcag aaagccgtat cgaggtttat
    58921 ctggctggtc agcttgaccg catcgacgag ctggaagttg aaatcctacc atttactgac
    58981 ttctacgcag acaaggattt cgcagcaact acagccaacc agtggcatac cattgcgaca
    59041 gcgtcgacga tttatacgac ttaatactct tcgaaaatct cttcaaacca cgtcagcttc
    59101 catctacaac ctcaaaacag tgttttgagc agcctgcagc tagcttccta gtttgctctt
    59161 tgattttcat tgagtataaa aacaagaaca ccttgcttgg cgcagggtgt ttcgcgtgaa
    59221 acagaagaat tatctggttt caaatgctac agttagacaa acttatgata aaatagcaga
    59281 aagtgaatgt ttcctaagag caattctatc gatgagcaat tggaggtatt atgctacact
    59341 taaaattagt aaaacaagaa atagaagctg aaaagccagc atctgtagaa gcttggatca
    59401 tttccgtcaa atttaaaaaa ggttgctacc gacatatata gattccaaaa acaaaaacgt
    59461 tagcggaact agcagatgtg attttatgga gttttgattt tgcaaatgat catgctcacg
    59521 catttttcat ggataatgtt gagtggagtc atgcagattc ttactttctt agctttgtta
    59581 gtgacgatgt tgaagaacgt tacacagaaa atgtctatct ggatagccta agtgtcaaac
    59641 aaaaatttaa gtttattttc gacttcggtg atgaatggcg ttttgaatgc caagtgctga
    59701 gagaaatcga gacagaggac gaagaagctt atctcgtacg ttcggttgga acgtcgccag
    59761 aacaatatcc agattatgat ggttttgact atgaagaatg gtaaaattga aatctaaaaa
    59821 acaattggaa tcagtctgtg taggcttagt atttcaatag acttcctgca aaactagaat
    59881 cctagttcat gattgataat accagcaatc aaattcattc gtaatccgaa gcgtttacga
    59941 tgatttcgat aggttgttga aaacatttta aatgtttcta ctttggcaaa gatgttctca
    60001 accttgcttc tctccttgga tagcgcatgg ttacaggctt tatcttcagc tgttagcggc
    60061 ttgagtttgc tggatttacg tggagtttgt gcttgaggat atatcttcat gggcccttga
    60121 taaccactgt cagccaagat tttaccagct tgtccgatat ttctgcaact cattttgaac
    60181 aacttcatat catgacaata gttcacagtg atatccaaag aaacaattct cccttgactt
    60241 gtgacaatcg cttgagcctt catagcgtga aatttctttt taccagaatg attcgctaat
    60301 tgttttttta gggcgattga tttttacttc cgtcgcatca atcattaccg tgtcctcaga
    60361 actgagagga gttcttgaaa tcgtaacacc actttgaaca agagttactt caacccattg
    60421 gctccgacgg attaagttgc tttcgtgaat accaaaatca gtcgcaattt cttcataagt
    60481 gcggtattct cgcacatatt gaagagtggc cataagaagg tcttctaggc ttaatttagg
    60541 ttttcgtcca ccttttgcgt gtttaagttg ataagctgtt tttaacacag ctaacatctc
    60601 ttcaaaagtg gtgcgctgaa caccaacaag acgcttaaat cgtgcatcgg ttagttgttt
    60661 acttgcttca taattttgtt tcgcaggaag tctattgact ccttggtagg ggtcaatgtt
    60721 tttttttcat ctatcccgag aattattttc ccgccatttg tatttgcaaa tgctgagtag
    60781 gtttcccaga aagactctgg aagattgttt ttagcttttt tgtattctaa atcaacccct
    60841 tcaaatttta agtccatatt tttcctttac atctgttttt tgtggttctg gtatttgttc
    60901 aagttgagtg ataatatagc taattgaatt tcgagagttt ttactcagtt aatttctttt
    60961 ttaacccact ttaatttctt ttttaacccg ggttaaaaaa gaaattaaag tgggttaatt
    61021 ttccttgact ta
//
LOCUS       DAVLHC010000007        57529 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.007, whole genome shotgun sequence.
ACCESSION   DAVLHC010000007 DAVLHC010000000
VERSION     DAVLHC010000007.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 57529)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 57529)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..57529
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.007"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            257..1786
                     /gene="rlrA"
                     /locus_tag="VXE25_000446"
     CDS             257..1786
                     /gene="rlrA"
                     /locus_tag="VXE25_000446"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000933118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PI-1 pilus transcriptional regulator RlrA"
                     /protein_id="HEV0770967.1"
                     /translation="MLNKYIEKRITDKITILNILLDIRSIELDELSTLTSLQSKSLLS
                     ILQELQETFEEELTFNLDTQQVQLIEHHSHQTNYYFHQLYNQSTILKILRFFLLQGNQ
                     SFNEFTQKEYISIATGYRVRQKCGLLLRSVGLDLVKNQVVGPEYRIRFLIALLQFHFG
                     IEIYDLNDGSMDWVTHMIVQSNSQLSHELLEITPDEYVHFSILVALTWKRREFPLEFP
                     ESKEFEKLKNLFMYPILMEHCQTYLEPHANMTFTQEELDYIFLVYCSANSSFSKDKWN
                     QEKKTHTIQLILQHTRGKHLLSKFKNILGNDISNSLSFLTALTFLTRTFLFGLQNLVP
                     YYNYYEHYGIESDKPLYHISKAIVQEWMTEQKIEGVIDQHRLYLFSLYLTETIFSSLP
                     AIPIFIILNNQADVNLIKSIILRNFTDKVASVTGYNILISPPPSEEHLTEPLIIITTK
                     EYLPYVKKQYPKGKHHFLTIALDLHVSQQRLIYQTIVDIRKEAFDKRVAMIAKKAHYL
                     L"
     gene            2051..3313
                     /locus_tag="VXE25_000447"
     CDS             2051..3313
                     /locus_tag="VXE25_000447"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
                     /protein_id="HEV0770968.1"
                     /translation="MEHINHTTLLIGIKDKNITLNKAIQHDTHIEVFATLDYHPPKCK
                     HCKGKQIKYDFQKPSKIPFIEIGAFPSLIRLKKRRFQCKSCRKVTVAETTLVQKNCQI
                     SEMVRQKIAQLLLNREALTHIASKLAISTSTSTVYRKLKQFHFQEDYTTLPEILSWDE
                     FSYQKGKLAFIAQDFNTKKIMTILDNRRQTTIRNHFFKYSKEARKKVKVVTVDMSGSY
                     IPLIKKLFPNAKIVLDRFHIVQHMSRALNQTRINIMKQFDDKSLEYRALKYYWKFILK
                     DSRKLSLKPFYARTFRETLTPRECLKKIFTLVPELKDYYDLYQLLLFHLQEKNTDQFW
                     GLIQDTLPHLNRTFKTTLSTFIRYKNYITNAIELPYSNAKLEATNKLIKDIKRNAFGY
                     RNFENFKKRIFIALNIKKERTKFVLSRA"
     gene            complement(3371..5695)
                     /gene="pflB"
                     /locus_tag="VXE25_000448"
     CDS             complement(3371..5695)
                     /gene="pflB"
                     /locus_tag="VXE25_000448"
                     /EC_number="2.3.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399021.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate C-acetyltransferase"
                     /protein_id="HEV0770969.1"
                     /translation="MVVKTVVEAQDIFDKAWEGFKGVDWKEKASVSRFVQANYTPYDG
                     DESFLAGPTERSLHIKKIVEETKAHYEETRFPMDTRPTSIADIPAGFIDKENEVIFGI
                     QNDELFKLNFMPKGGIRMAETTLKENGYEPDPAVHEIFTKYVTTVNDGIFRAYTSNIR
                     RARHAHTVTGLPDAYSRGRIIGVYARLALYGADYLMQEKVNDWNAIKEIDEETIRLRE
                     EVNLQYQALQQVVRLGDLYGVDVRKPAMNVKEAIQWVNIAFMAVCRVINGAATSLGRV
                     PIVLDIFAERDLARGTFTESEIQEFVDDFVMKLRTVKFARTKAYDQLYSGDPTFITTS
                     MAGMGNDGRHRVTKMDYRFLNTLDNIGNSPEPNLTVLWTDKLPYNFRRYCMHMSHKHS
                     SIQYEGVTTMAKDGYGEMSCISCCVSPLDPENEEQRHNIQYFGARVNVLKALLTGLNG
                     GYDDVHKDYKVFDIEPIRDEVLEFESVKANFEKSLDWLTDTYVDALNIIHYMTDRYNY
                     EAVQMAFLPTKQRANMGFGICGFANTVDTLSAIKYATVKPIRDEDGYIYDYETIGDYP
                     RWGEDDPRSNELAEWLIEAYTTRLRSHKLYKDAEATVSLLTITSNVAYSKQTGNSPVH
                     KGVYLNEDGSVNLSKLEFFSPGANPSNKAKGGWLQNLNSLSSLDFSYAADGISLTTQV
                     SPRALGKTRDEQVDNLVTILDGYFENGGQHVNLNVMDLNDVYEKIMSGEDVIVRISGY
                     CVNTKYLTPEQKTELTQRVFHEVLSMDDALDALS"
     gene            6043..6745
                     /locus_tag="VXE25_000449"
                     /pseudo
     CDS             6043..6745
                     /locus_tag="VXE25_000449"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000904550.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(6892..7737)
                     /locus_tag="VXE25_000450"
     CDS             complement(6892..7737)
                     /locus_tag="VXE25_000450"
                     /EC_number="3.6.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000273482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="undecaprenyl-diphosphate phosphatase"
                     /protein_id="HEV0770970.1"
                     /translation="MYLIEILKSIFFGIVEGITEWLPISSTGHLILAEEFIQYQNQNE
                     AFMSMFNVVIQLGAILAVMVIYFNKLNPFKPTKDKQEVRKTWRLWLKVLIATLPLLGV
                     FKFDDWFDTHFHNMVSVALMLIIYGVAFIYLEKRNKARAIEPSVTELDKLPYTTAFYI
                     GLFQVLALLPGTSRSGATIVGGLLNGTSRSVVTEFTFYLGIPVMFGASALKIFKFVKA
                     GELLSFGQLFLLLVAMGVAFAVSMVAIRFLTSYVKKHDFTLFGKYRIVLGSVLLLYSF
                     VRLFV"
     gene            7993..8862
                     /locus_tag="VXE25_000451"
     CDS             7993..8862
                     /locus_tag="VXE25_000451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001841243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS110 family transposase"
                     /protein_id="HEV0770971.1"
                     /translation="MLYVGIDVAKNKHDVTALNVQGKTVLKPLTFSNNKAGFELLDLS
                     FRQLNQDCLIALKLLSDPNREQFQHDNRQVELKILARHIHRLKKKQSDWKVQYTRCLD
                     IIFPELDKIVGKHSEYTYQLLTRYPNPQKRLEARFDKLIEIKRLTASKIQDILSIAPR
                     SIGTTSPAREFEIIEIIKHYKRLIDKAETCVNDLMAEFNSVITTVTGIGGRLGAVILA
                     EIRNIHAFDNPAQLQAFAGLDSSIYQSGQIDLAGRMIKRGSPHLRWALIQAAKACARF
                     SPAFKAYLKTKLE"
     gene            complement(9163..11052)
                     /locus_tag="VXE25_000452"
     CDS             complement(9163..11052)
                     /locus_tag="VXE25_000452"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000750662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2207 domain-containing protein"
                     /protein_id="HEV0770972.1"
                     /translation="MKKTFFLLVLGLFCLLPLSVFAIDFKINSYQGDLYIHADNTAEF
                     RQKIVYQFEEDFKGQIVGLGRAGKMPSGFDIDPHPKVQAAKNGAELADVTSEVTEEAD
                     GYTVRVYNPGQEGDIVEVDLVWNLKNLLFLYDDIAELNWQPLTDSSESIEKFEFHVRG
                     DKGAEKLFFHTGKLFREGTIEKSNLDYTIRLDNLPAKRGVELHAYWPRTDFASARDQG
                     LKGNRLEEFNKIEDSIVREKDQSKQLVTWVLPSILSISLLLSVCFYFIYRRKTTPSVK
                     YAKNHRLYEPPMELEPMVLSEAVYSTSLEEVSPLVKGAGKFTFDQLIQATLLDVMDRG
                     NVSIISEGDAVGLRLVKEDGLSSFERDCLNLAFSGKKEETLSNLFADYKVSDSLYRRA
                     KVSDEKRIQARGLQLKSSFEEVLNQMQEGVRKRVSFWGLPDYYRPLTGGEKALQVGMG
                     ALTILPLFIGFGLFLYSLDVHGYLYLPLPILGFLGLVLSVFYYWKLRLDNRDGVLNEA
                     GAEVYYLWTSFENMLREIARLDKAELESIVVWNRLLVYATLFGYADKVSHLMKVHQIQ
                     VENPDINLYVAYGWHSMFYHSSAQMSHYASVANTASTYSVSSGSGSSGGGFSGGGGGG
                     SIGAF"
     gene            11190..12755
                     /locus_tag="VXE25_000453"
     CDS             11190..12755
                     /locus_tag="VXE25_000453"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding
                     protein/permease"
                     /protein_id="HEV0770973.1"
                     /translation="MRKIYLSIFTSLLLMLGLVNVAQADEYLRIGMEAAYAPFNWTQD
                     DDSNGAVKIDGTNQYANGYDVQIAKKIAKDLGKEPLVVKTKWEGLVPALTSGKIDMII
                     AGMSPTAERKQEIAFSSSYYTSEPVLLVKKDSAYASAKSLDDFNGAKITSQQGVYLYD
                     LIAQIPGAKKETAMGDFAQMRQALEAGVIDAYVSERPEALTAEAANSKFKMIQVEPGF
                     KTGEEDTAIAIGLRKNDNRISQINASIETISKDDQVALMDRMIKEQPAEATTTEETSS
                     SFFSQVAKILSENWQQLLRGAGITLLISIVGTIIGLIIGLAIGVFRTAPLSENKAIYG
                     LQKLVGWVLNVYIEIFRGTPMIVQSMVIYYGTAQAFGINLDRTLAAIFIVSINTGAYM
                     TEIVRGGILAVDKGQFEAATALGMTHNQTMRKIVLPQVVRNILPATGNEFVINIKDTS
                     VLNVISVVELYFSGNTVATQTYQYFQTFTIIAVIYFVLTFTVTRILRFIERRMDMDTY
                     TTGANQMQTEDLK"
     gene            12755..13495
                     /locus_tag="VXE25_000454"
     CDS             12755..13495
                     /locus_tag="VXE25_000454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000189492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEV0770974.1"
                     /translation="MTQAILEIKHLKKSYGQNEVLKDISLTVHKGEVISIIGSSGSGK
                     STFLRSINLLETPTDGQILYHGQNVLEKGYDLTQYREKLGMVFQSFNLFENLNVLENT
                     IVAQTTVLKRERTEAEKIAKENLEKVGMGERYWQAKPKQLSGGQKQRVAIARALSMNP
                     DAILFDEPTSALDPEMVGEVLKIMQDLAQEGLTMIVVTHEMEFARDVSHRVIFMDKGV
                     IAEEGKPEDLFTNPKEDRTKEFLQRYLK"
     gene            complement(13604..13819)
                     /locus_tag="VXE25_000455"
     CDS             complement(13604..13819)
                     /locus_tag="VXE25_000455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002893653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0770975.1"
                     /translation="MAKSNFEKVESVVGWVRDKKITGYRISKETNAREMSIIALAQGR
                     AKVKNISFETALGLIDFYEKNYEKFED"
     gene            complement(14690..15940)
                     /gene="ilvA"
                     /locus_tag="VXE25_000456"
     CDS             complement(14690..15940)
                     /gene="ilvA"
                     /locus_tag="VXE25_000456"
                     /EC_number="4.3.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine ammonia-lyase IlvA"
                     /protein_id="HEV0770976.1"
                     /translation="MLSSKDIIKAHKVLNGVVVNTPLDYDHYLSEKYGAKIYLKKENA
                     QRVRSFKIRGAYYAISQLSKEERERGVVCASAGNHAQGVAYTCNEMKIPATIFMPITT
                     PQQKIGQVRFFGGDFVTIKLVGDTFDASAKAAQEFTVSENRTFIDPFDDAHVQAGQGT
                     VAYEILEEARKESIDFDAVLVPVGGGGLIAGVSTYIKETSPEIEVIGVEANGARSMKA
                     AFEAGGPVKLKEIDKFADGIAVQKVGQLTYEATRQHIKTLVGVDEGLISETLIDLYSK
                     QGIVAEPAGAASIASLEVLAEYIKGKTICCIISGGNNDINRMPEMEERALIYDGIKHY
                     FVVNFPQRPGALREFVNDILGPNDDITRFEYIKRASKGTGPVLIGIALADKHDYAGLI
                     RRMEGFDPAYINLNGNETLYNMLV"
     gene            complement(15990..16346)
                     /locus_tag="VXE25_000457"
     CDS             complement(15990..16346)
                     /locus_tag="VXE25_000457"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001027901.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketol-acid reductoisomerase"
                     /protein_id="HEV0770977.1"
                     /translation="MNITNLFSIKTGCDETDRQLQKLFFQLDLQLGELTDQLRKLDSN
                     FVPRSQFVDTLDLNDVEYKEILNYFIFHRNDSEESLVEWLYDWISTNRYELPKEFSIR
                     MAHKYHESVTEVFGDE"
     gene            complement(16584..16820)
                     /locus_tag="VXE25_000458"
     CDS             complement(16584..16820)
                     /locus_tag="VXE25_000458"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0770978.1"
                     /translation="MLADQNKADWSYDENAVINIYDDANFEDGRLHMTFEQFFKLAQI
                     AREEGLEIHSPFERAGATKSARYIAKWILRNKKH"
     gene            complement(16927..17949)
                     /gene="ilvC"
                     /locus_tag="VXE25_000459"
     CDS             complement(16927..17949)
                     /gene="ilvC"
                     /locus_tag="VXE25_000459"
                     /EC_number="1.1.1.86"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145054.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketol-acid reductoisomerase"
                     /protein_id="HEV0770979.1"
                     /translation="MTVQMEYEKDVKVAALDGKKIAVIGYGSQGHAHAQNLRDSGRDV
                     IIGVRPGKSFDKAKEDGFDTYTVAEATKLADVIMILAPDEIQQELYEAEIAPNLEAGN
                     AVGFAHGFNIHFEFIKVPADVDVFMCAPKGPGHLVRRTYEEGFGVPALYAVYQDATGN
                     AKNIAMDWCKGVGAARVGLLETTYKEETEEDLFGEQAVLCGGLTALIEAGFEVLTEAG
                     YAPELAYFEVLHEMKLIVDLIYEGGFKKMRQSISNTAEYGDYVSGPRVITEQVKENMK
                     AVLADIQNGKFANDFVNDYKAGRPKLTAYREQAANLEIEKVGAELRKAMPFVGKNDDD
                     AFKIYN"
     gene            complement(18015..18491)
                     /gene="ilvN"
                     /locus_tag="VXE25_000460"
     CDS             complement(18015..18491)
                     /gene="ilvN"
                     /locus_tag="VXE25_000460"
                     /EC_number="2.2.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002927678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetolactate synthase small subunit"
                     /protein_id="HEV0770980.1"
                     /translation="MRRMLTAKLQNRSGVLNRFTGVLSRRQVNIESISVGATEDPNVS
                     RITIIIDVASHDEVEQIIKQLNRQIDVIRIRDITDKPHLEREVILVKMSAPAEKRAEI
                     LAIIQPFRATVVDVAPSSITIQMTGNAEKSEALLRVIRPYGIRNIARTGATGFTRD"
     gene            complement(18484..20184)
                     /locus_tag="VXE25_000461"
     CDS             complement(18484..20184)
                     /locus_tag="VXE25_000461"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000411733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetolactate synthase large subunit"
                     /protein_id="HEV0770981.1"
                     /translation="MEKISLESPKTGSDLVLETLRDLGVDTIFGYPGGAVLPFYDAIY
                     NFKGIRHILGRHEQGCLHEAEGYAKSTGKLGVAVVTSGPGATNAITGIADAMSDSVPL
                     LVFTGQVARAGIGKDAFQEADIVGITMPITKYNYQVRETADIPRIITEAVHIATTGRP
                     GPVVIDLPKDISALETDFIYSPEVNLPSYQPTLEPNDMQIKKILKQLSKAKKPVLLAG
                     GGISYAEAATELNEFAERYQIPVVTSLLGQGTIATSHPLFLGMGGMHGSFAANIAMTE
                     ADFMISIGSRFDDRLTGNPKTFAKNAKVAHIDIDPAEIGKIISADIPVVGDAKKALQM
                     LLAEPTVHNNTEKWIEKVTKDKNRVRSYDKKERVVQPQAVIERIGELTNGDAIVVTDV
                     GQHQMWTAQYYPYQNERQLVTSGGLGTMGFGIPAAIGAKIANPDKEVVLFVGDGGFQM
                     TNQELAILNIYKVPIKVVMLNNHSLGMVRQWQESFYEGRTSESVFDTLPDFQLMAQAY
                     GIKNYKFDNPETLAQDLEVITEDVPMLIEVDISRKEQVLPMVPAGKSNHEMLGVQFHA
                     "
     gene            complement(20385..22052)
                     /locus_tag="VXE25_000462"
     CDS             complement(20385..22052)
                     /locus_tag="VXE25_000462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000036655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DAK2 domain-containing protein"
                     /protein_id="HEV0770982.1"
                     /translation="MSKITTSLFQEMVQAASTRLNKQAEYVNSLNVFPVPDGDTGTNM
                     GMTIENGAKEVADKPASTVGEVASILAKGLLMGARGNSGVITSQLFRGFSQAIKDKDE
                     LTGQDLALAFQSGVEVAYKAVMKPVEGTILTVSRGAAIGAKKKAEQTDDTVEVMRAAL
                     EGAKTALAKTPDMLPVLKEVGVVDSGGQGLVFIYEGFLSALTGEYIASEDFVATPANM
                     SEMINVEHHKSVAGHVATEDITFGYCTEIMVALKQGPTYAKDFDYDEFRNYLDELGDS
                     LLVVNDDEIVKVHVHTEDPGLVMQEGLKYGSLVKVKVDNMRNQHEAQVEKEATQVIKS
                     AEEKEYALIAVVAGKGLADIFCSQGVDYVIEGGQTMNPSTEDFIKAVEQVNARNIIFL
                     PNNKNIFMAAQSAAEVLEQPAVVVEARTLPQGMTSLLAFDPSKSIEENQERMTAALRD
                     VVSGSVTTAVRDTTIDGLEIHENDNLGMVDGKILVSNPDMHQTLTETLKHMLDEDSEI
                     VTFYVGEDGSEELANEIAQEIVEEFEDVEVEIHQGQQPVYPYLFSVE"
     gene            complement(22055..22420)
                     /locus_tag="VXE25_000463"
     CDS             complement(22055..22420)
                     /locus_tag="VXE25_000463"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HEV0770983.1"
                     /translation="MTVKINTKDGQIELTDEVIATVVGGAATEIFGVVGMASKNALKD
                     NFQALLGKENYSKGVVVKAAEDGSIAVDVYTVLSYGTKISEVSKNIQERVAFSLENQL
                     GITAQTVNVYIQNIKVVGE"
     gene            complement(22577..22765)
                     /locus_tag="VXE25_000464"
     CDS             complement(22577..22765)
                     /locus_tag="VXE25_000464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008536053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L28"
                     /protein_id="HEV0770984.1"
                     /translation="MAKVCYFTGRKTVSGNNRSHAMNQTKRAVKPNLQKVTVLIDGKP
                     KKVWASARALKSGKVERV"
     gene            complement(22881..23057)
                     /locus_tag="VXE25_000465"
     CDS             complement(22881..23057)
                     /locus_tag="VXE25_000465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001858191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase family 8"
                     /protein_id="HEV0770985.1"
                     /translation="MDLDIVVRKSIDELWDLDLTAIPLAAVRDDFYTHNFNSGVLLIN
                     NGMWRAENVTQDLI"
     gene            complement(23168..23366)
                     /locus_tag="VXE25_000466"
                     /pseudo
     CDS             complement(23168..23366)
                     /locus_tag="VXE25_000466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808887.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase family 8"
     gene            complement(23621..25165)
                     /locus_tag="VXE25_000467"
     CDS             complement(23621..25165)
                     /locus_tag="VXE25_000467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011681503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 3"
                     /protein_id="HEV0770986.1"
                     /translation="MNIQEEIKKRRTFAIISHPDAGKTTITEQLLYFGGEIREAGTVK
                     GKKTGTFAKSDWMDIEKQRGISVTSSVMQFDYDGKRVNILDTPGHEDFSEDTYRTLMA
                     VDAAVMVVDSAKGIEAQTKKLFEVVKHRGIPVFTFMNKLDRDGREPLDLLQELEEILG
                     IASYPMNWPIGMGKAFEGLYDLYNQRLELYKGDERFASLEDGDKLFGSNPFYEQVKDD
                     IELLNEAGNEFSEEAILAGELTPVFFGSALTNFGVQTFLEIFLKFAPEPHGHKKTDGE
                     IVDPYDKDFSGFVFKIQANMDPRHRDRIAFVRIVSGEFERGMSVNLPRTGKGAKLSNV
                     TQFMAESRENVTNAVSGDIIGVYDTGTYQVGDTLTVGKNKFEFEPLPTFTPEIFMKVS
                     AKNVMKQKSFHKGIEQLVQEGAVQLYKNYQTGEYMLGAVGQLQFEVFKHRMEGEYNAE
                     VVMSPMGKKTVRWIKPEDLDERMSSSRNILAKDRFDQPVFLFENDFALRWFADKYPDV
                     ELEEKM"
     gene            25378..25680
                     /gene="gatC"
                     /locus_tag="VXE25_000468"
     CDS             25378..25680
                     /gene="gatC"
                     /locus_tag="VXE25_000468"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006147946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatC"
                     /protein_id="HEV0770987.1"
                     /translation="MKITQEEVTHVANLSKLRFSEEETAAFATTLSKIVDMVELLGEV
                     DTTGVAPTTTMADRKTVLRPDVAEEGTDRDRLFKNVPEQDNYYIKVPAILDDGGDA"
     gene            25680..27146
                     /gene="gatA"
                     /locus_tag="VXE25_000469"
     CDS             25680..27146
                     /gene="gatA"
                     /locus_tag="VXE25_000469"
                     /EC_number="6.3.5.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatA"
                     /protein_id="HEV0770988.1"
                     /translation="MTFNNKTIEELHNLLVSKEISATELTQATLENIKSREEALNSFV
                     TIAEEQALVQAKAIDEAGIDANNVLSGIPLAVKDNISTDGILTTAASKMLYNYEPIFD
                     ATAVANAKTKGMIVVGKTNMDEFAMGGSGETSHYGATKNAWDHSKVPGGSSSGSAAAV
                     ASGQVRLSLGSDTGGSIRQPAAFNGIVGLKPTYGTVSRFGLIAFGSSLDQIGPFAPTV
                     KENALLLNAIASEDTKDSTSAPVRIADFTSKIGQDIKGMKIALPKEYLGEGIDPEVKE
                     TILNAAKHFEKLGAIVEEVSLPHSKYGVAVYYIIASSEASSNLQRFDGIRYGYRAEDA
                     TNLDEIYVNSRSQGFGEEVKRRIMLGTFSLSSGYYDAYYKKAGQVRTLIIQDFEKVFA
                     DYDLILGPTAPSVAYDLDSLNHDPVAMYLADLLTIPVNLAGLPGISIPAGFSQGLPVG
                     LQLIGPKYSEETIYQAAAAFEATTDYHKQQPVIFGGDN"
     gene            27146..28588
                     /gene="gatB"
                     /locus_tag="VXE25_000470"
     CDS             27146..28588
                     /gene="gatB"
                     /locus_tag="VXE25_000470"
                     /EC_number="6.3.5.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002946582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatB"
                     /protein_id="HEV0770989.1"
                     /translation="MNFETVIGLEVHVELNTNSKIFSPTSAHFGNDQNANTNVIDWSF
                     PGVLPVLNKGVVDAGIKAALALNMDLHKKMHFDRKNYFYPDNPKAYQISQFDEPIGYN
                     GWIEVELEDGTTKKIGIERAHLEEDAGKNTHGTDGYSYVDLNRQGVPLIEIVSEADMR
                     SPEEAYAYLTALKEVIQYAGISDVKMEEGSMRVDANISLRPYGQEKFGTKTELKNLNS
                     FSNVRKGLEYEVQRQAEILRSGGQIRQETRRYDEANKTTILMRVKEGAADYRYFPEPD
                     LPLFEISDEWIEEMRTELPEFPKERRARYVSDLGLSDYDASQLTANKVTSDFFEKAVA
                     LGGDAKQVSNWLQGEVAQFLNAEGKTLEQIELTPENLVEMITIIEDGTISSKIAKKVF
                     VHLAKNGGGAREYVEKAGMVQISDPAILIPIIHQVFADNEAAVADFKSGKRNADKAFT
                     GFLMKATKGQANPQVALKLLAQELAKLKEN"
     gene            28717..29277
                     /gene="efp"
                     /locus_tag="VXE25_000471"
     CDS             28717..29277
                     /gene="efp"
                     /locus_tag="VXE25_000471"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000568636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor P"
                     /protein_id="HEV0770990.1"
                     /translation="MIEASKLKAGMTFETADGKLIRVLEASHHKPGKGNTIMRMKLRD
                     VRTGSTFDTSYRPEEKFEQAIIETVPAQYLYKMDDTAYFMNTETYDQYEIPVVNVENE
                     LLYILENSDVKIQFYGTEVIGVTVPTTVELTVAETQPSIKGATVTGSGKPATMETGLV
                     VNVPDFIEAGQKLVINTAEGTYVSRA"
     gene            29299..29688
                     /locus_tag="VXE25_000472"
     CDS             29299..29688
                     /locus_tag="VXE25_000472"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517858.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HEV0770991.1"
                     /translation="MGIEEQLGEIVIAPRVLEKIIAIATAKVEGVHSFSNRSVSDTLS
                     KLSLGRGVYLKNVDEELTADIYLYLEYGVKVPKVAVAIQKAVKDAVRNMADVELAAIN
                     IHVAGIVPDKTPKPELKDLFDEDFLND"
     gene            29681..30103
                     /gene="nusB"
                     /locus_tag="VXE25_000473"
     CDS             29681..30103
                     /gene="nusB"
                     /locus_tag="VXE25_000473"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000203663.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antitermination factor NusB"
                     /protein_id="HEV0770992.1"
                     /translation="MTSPLLESRRQLRKCAFQALMSLEFGTNVETACRFAYTHDREDT
                     DVQLPAFLIDLVSGVQAKKEELDKQITQHLKVGWTIERLTLVERNLLRLGVFEITSFD
                     TPQLVAVNEAIELAKDFSDQKSARFINGLLSQFVTEEQ"
     gene            complement(30152..30529)
                     /locus_tag="VXE25_000474"
     CDS             complement(30152..30529)
                     /locus_tag="VXE25_000474"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000244505.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEV0770993.1"
                     /translation="MVLSNGQPTFLSTILSFVLLVIIGPVFEETLDRGYLMNTFFPKS
                     KYYLDVILSGLIFGISHLILSHRDPISLLYYSLIGFFFALVYRSTDNLRLTILCHSFF
                     NFLNHAKPIWIFVYNYIYYHFFR"
     gene            complement(30892..31077)
                     /gene="briC"
                     /locus_tag="VXE25_000475"
     CDS             complement(30892..31077)
                     /gene="briC"
                     /locus_tag="VXE25_000475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000148168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biofilm-regulating peptide BriC"
                     /protein_id="HEV0770994.1"
                     /translation="MTGTNTFTVLSTEDLEQTSGGLAVWEDGYSRWLYYREFAPYMRQ
                     GALNSYIDAWKYGFRAG"
     gene            complement(31236..32003)
                     /locus_tag="VXE25_000476"
     CDS             complement(31236..32003)
                     /locus_tag="VXE25_000476"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001017399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase carboxyl transferase
                     subunit alpha"
                     /protein_id="HEV0770995.1"
                     /translation="MNIAKIVREAREQSRLTTLDFATGIFDEFIQLHGDRSFRDDGAV
                     VGGIGWLGDQAVTVVGIQKGKSLQDNLKRNFGQPHPEGYRKALRLMKQAEKFGRPVVT
                     FINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGGALALAVADRV
                     WMLENSIYAILSPEGFASILWKDGTRAMEAAELMKITSHELLEMDVVDKVISEVGLSS
                     KELIKSVKKELQTELARLSQKPLEELLEERYQRFRKY"
     gene            complement(32000..32866)
                     /locus_tag="VXE25_000477"
     CDS             complement(32000..32866)
                     /locus_tag="VXE25_000477"
                     /EC_number="6.4.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001173351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase carboxyltransferase
                     subunit beta"
                     /protein_id="HEV0770996.1"
                     /translation="MALFSKKDKYIRINPNRSVREKPQAKPEVPDELFSQCPGCKHTI
                     YQKDLGSERICPHCSYTFRISAQERLALTIDMGTFKELFTGIESKDPLHFPGYQKKLA
                     SMREKTGLHEAVVTGTALIKGQTVALGIMDSNFIMASMGTVVGEKITRLFEYATVEKL
                     PVVLFTASGGARMQEGIMSLMQMAKISAAVKRHSNAGLFYLTILTDPTTGGVTASFAM
                     EGDIILAEPQSLVGFAGRRVIENTVRESLPEDFQKAEFLLEHGFVDAIVKRRDLPDTI
                     ASLVRLHGGSPR"
     gene            complement(32903..34270)
                     /gene="accC"
                     /locus_tag="VXE25_000478"
     CDS             complement(32903..34270)
                     /gene="accC"
                     /locus_tag="VXE25_000478"
                     /EC_number="6.3.4.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000488661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="HEV0770997.1"
                     /translation="MFRKILIANRGEIAVRIIRAARELGIATVAVYSTADKEALHTLL
                     ADEAVCIGPGKATESYLNINAVLSAAVLTEAEAIHPGFGFLSENSKFATMCEEVGIKF
                     IGPSGHVMDMMGDKINARAQMIKAGVPVIPGSDGEVHNSEEALIVAEKIGYPVMLKAS
                     AGGGGKGIRKVEKPDDLVSAFETASSEAKANYGNGAMYIERVIYPARHIEVQILGDEH
                     GHVIHLGERDCSLQRNNQKVLEESPSIAIGKTLRHEIGAAAVRAAEFVGYENAGTIEF
                     LLDEASSNFYFMEMNTRVQVEHPVTEFVSGVDIVKEQICIAAGQPLSVKQEDIVLRGH
                     AIECRINAENPAFNFAPSPGKITNLYLPSGGVGLRVDSAVYPGYTIPPYYDSMIAKII
                     VHGENRFDALMKMQRALYELEIEGVQTNADFQLDLISDRNVIAGDYDTSFLMETFLPK
                     YQEKE"
     gene            complement(34282..34704)
                     /gene="fabZ"
                     /locus_tag="VXE25_000479"
     CDS             complement(34282..34704)
                     /gene="fabZ"
                     /locus_tag="VXE25_000479"
                     /EC_number="4.2.1.59"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-hydroxyacyl-ACP dehydratase FabZ"
                     /protein_id="HEV0770998.1"
                     /translation="MIDIQGIKEALPHRYPMLLVDRVLEVSEDTIVAIKNVTINEPFF
                     NGHFPQYPVMPGVLIMEALAQTAGVLELSKPENKGKLVFYAGMDKVKFKKQVVPGDQL
                     VMTATFVKRRGTIAVVEAKAEVDGKLAASGILTFAIGN"
     gene            complement(34701..35186)
                     /locus_tag="VXE25_000480"
     CDS             complement(34701..35186)
                     /locus_tag="VXE25_000480"
                     /EC_number="6.4.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001052236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein"
                     /protein_id="HEV0770999.1"
                     /translation="MNLNDIKDLMTQFDQSSLREFSYKNGTDELQFSKNEARPVPEVA
                     TQVAPAPVLATPSPVAPTSAPAETVAEEVPAPAEASVASEGNLVESPLVGVVYLAAGP
                     DKPAFVTVGDSVKKGQTLVIIEAMKVMNEIPAPKDGVVTEILVSNEEMVEFGKGLVRI
                     K"
     gene            complement(35189..36424)
                     /gene="fabF"
                     /locus_tag="VXE25_000481"
     CDS             complement(35189..36424)
                     /gene="fabF"
                     /locus_tag="VXE25_000481"
                     /EC_number="2.3.1.179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000774039.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-ketoacyl-ACP synthase II"
                     /protein_id="HEV0771000.1"
                     /translation="MKLNRVVVTGYGVTSPIGNTPEEFWNSLATGKIGIGGITKFDHS
                     DFDVHNAAEIQDFPFDKYFVKKDTNRFDNYSLYALYAAQEAVNHANLDVEALNRDRFG
                     VIVASGIGGIKEIEDQVLRLHEKGPKRVKPMTLPKALPNMASGNVAMRFGANGVCKSI
                     NTACSSSNDAIGDAFRSIKFGFQDVMLVGGTEASITPFAIAGFQALTALSTTEDPTRA
                     SIPFDKDRNGFVMGEGSGMLVLESLEHAEKRGATILAEVVGYGNTCDAYHMTSPHPEG
                     QGAIKAIKLALEEAEISPEQVAYVNAHGTSTPANEKGESGAIVAVLGKEVPVSSTKSF
                     TGHLLGAAGAVEAIVTIEAMRHNFVPMTAGTSEVSDYIEANVVYGQGLEKEIPYAISN
                     TFGFGGHNAVLAFKRWENR"
     gene            complement(36446..37177)
                     /gene="fabG"
                     /locus_tag="VXE25_000482"
     CDS             complement(36446..37177)
                     /gene="fabG"
                     /locus_tag="VXE25_000482"
                     /EC_number="1.1.1.100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacyl-[acyl-carrier-protein] reductase"
                     /protein_id="HEV0771001.1"
                     /translation="MKLEHKNIFITGSSRGIGLAIAHKFAQAGANIVLNSRGAISEEL
                     LAEFSNYGIKVVPISGDVSDFADAKRMIDQAIAELGSVDVLVNNAGITQDTLMLKMTE
                     ADFEKVLKVNLTGAFNMTQSVLKPMMKAREGAIINMSSVVGLMGNIGQANYAASKAGL
                     IGFTKSVAREVASRNIRVNVIAPGMIESDMTAILSDKIKEATLAQIPMKEFGQAEQVA
                     DLTVFLAGQDYLTGQVIAIDGGLSM"
     gene            complement(37211..38131)
                     /gene="fabD"
                     /locus_tag="VXE25_000483"
     CDS             complement(37211..38131)
                     /gene="fabD"
                     /locus_tag="VXE25_000483"
                     /EC_number="2.3.1.39"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000167658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACP S-malonyltransferase"
                     /protein_id="HEV0771002.1"
                     /translation="MTKTAFLFAGQGAQYLGMGRDFYDQYPIVKETIDRASQVLGYDL
                     RYLIDTEEDKLNQTRYTQPAILATSVAIYRLLQEKGYQPDMVAGLSLGEYSALVASGA
                     LDFEDAVALVAKRGAYMEEAAPADSGKMVAVLNTPVEVIEEACQKASELGVVTPANYN
                     TPAQIVIAGEVVAVDRAVELLQEAGAKRLIPLKVSGPFHTALLEPASQKLAETLAQVS
                     FSDFTCPLVGNTEAAVMQKEDIAQLLTRQVKEPVRFYESIGVMQEAGISNFIEIGPGK
                     VLSGFVKKIDQTAHLAHVEDQASLVALLEK"
     gene            complement(38124..39098)
                     /gene="fabK"
                     /locus_tag="VXE25_000484"
     CDS             complement(38124..39098)
                     /gene="fabK"
                     /locus_tag="VXE25_000484"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000857459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-[acyl-carrier-protein] reductase FabK"
                     /protein_id="HEV0771003.1"
                     /translation="MKTRITELLKIDYPIFQGGMAWVADGDLAGAVSKAGGLGIIGGG
                     NAPKEVVKANIDKIKSLTDKPFGVNIMLLSPFVEDIVDLVIEEGVKVVTTGAGNPSKY
                     MERFHEAGIIVIPVVPSVALAKRMEKIGADAVIAEGMEAGGHIGKLTTMTLVRQVATA
                     ISIPVIAAGGIADGEGAAAGFMLGAEAVQVGTRFVVAKESNAHPNYKEKILKARDIDT
                     TISAQHFGHAVRAIKNQLTRDFELAEKDAFKQEDPDLEIFEQMGAGALAKAVVHGDVD
                     GGSVMAGQIAGLVSKEETAEEILKDLYYGAAKKIQEEASRWAGVVRND"
     gene            complement(39217..39441)
                     /locus_tag="VXE25_000485"
     CDS             complement(39217..39441)
                     /locus_tag="VXE25_000485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000257841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl carrier protein"
                     /protein_id="HEV0771004.1"
                     /translation="MAVFEKVQEIIVEELGKDASEVTLESTFDDLDADSLDLFQVISE
                     IEDAFDIQIEAENDLKTVGDLVAYVEEQAK"
     gene            complement(39501..40475)
                     /locus_tag="VXE25_000486"
     CDS             complement(39501..40475)
                     /locus_tag="VXE25_000486"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262906.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketoacyl-ACP synthase III"
                     /protein_id="HEV0771005.1"
                     /translation="MAFAKISQVAHYVPEQVVTNHDLAQIMDTNDEWISSRTGIRQRH
                     ISRTESTSDLATEVAKKLMAKAGITGKELDFIILATITPDSMMPSTAARVQANIGANK
                     AFAFDLTAACSGFVFALSTAEKFIASGRFQKGLVIGSETLSKAVDWSDRSTAVLFGDG
                     AGGVLLEASEQEHFLAESLNSDGSRSECLTYGHSGLHSPFSDQESADSFLKMDGRTVF
                     DFAIRDVAKSIKQTIDESPIEVTDLDYLLLHQANDRILDKMARKIGVDRAKLPANMME
                     YGNTSAASIPILLSECVEQGLIPLDGSQTVLLSGFGGGLTWGTLILTI"
     gene            complement(40475..40909)
                     /locus_tag="VXE25_000487"
     CDS             complement(40475..40909)
                     /locus_tag="VXE25_000487"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520594.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HEV0771006.1"
                     /translation="MDYQRINEYLTSIFNNVLVIEEVNLRGSRFKDISIKEMHTIDVI
                     GKAPDVTPSQVSKELMVTLGTVTTSLNNLERKGYIERVRSEQDRRVVHLHLTKKGRLI
                     HRLHKRFHKAMVEKIIDGMSEEEIAVMGKGLTNLYQFLEDLK"
     gene            complement(41003..41788)
                     /locus_tag="VXE25_000488"
     CDS             complement(41003..41788)
                     /locus_tag="VXE25_000488"
                     /EC_number="4.2.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-CoA hydratase"
                     /protein_id="HEV0771007.1"
                     /translation="MEHIIYQLEEDLAILTLNRPEVANGFHIPMCEEILEALTLAEEN
                     PAVHFILINANGKVFSVGGDLVEMKRAVDEDDIPSLTKIAELVNTISYKIKQIAKPVL
                     MEVDGAVAGAAANMAVAADFCLATDKAKFIQAFVGVGLAPDAGGIHLLSRSIGVTRAA
                     QLAMTGEALTAEKALEWGLVYRVSEAEKLEKTREQLLKKLRRASSNSYAAIKKLVWES
                     QFKDWQGYATLELNLQKSLAQTEDFKEGVRAHSERRRPKFTGK"
     gene            42113..43477
                     /locus_tag="VXE25_000489"
     CDS             42113..43477
                     /locus_tag="VXE25_000489"
                     /EC_number="2.7.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004251870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate kinase"
                     /protein_id="HEV0771008.1"
                     /translation="MKVVKFGGSSLASASQLEKVLNIVKSDSERRFVVVSAPGKRNAE
                     DTKVTDALIKYYRDYVAGNDISKSQSWIIDRYAAMVSELGLKPAVLEKISKSIHALAT
                     LPIEENEFLYDTFLAAGENNNAKLIAAYFNQNGIDARYMHPREAGIVVTSEPGHARII
                     PSSYDKIEELTNTNEVLVIPGFFGVTKENQICTFSRGGSDITGSIIAAGVKADLYENF
                     TDVDGIFAAHPGIIHQPHSIPELTYREMRELAYAGFSVLHDEALLPAYRGKIPLVIKN
                     TNNPDHPGTRIVLKHSNDEFPVVGIAGDSGFVSINMSKYLMNREVGFGRKVLQILEEL
                     NIGWEHMPTGIDDLSIILRSRQLTPIKEEEILRQLVQKAKVDHAEIEHDLSIIMIVGE
                     KMKSHIGVTATATRALSENKINIQMMSQGSSEVSIMFVVNKDQEKAAIKALYNAFFGE
                     SKED"
     gene            43480..43851
                     /locus_tag="VXE25_000490"
     CDS             43480..43851
                     /locus_tag="VXE25_000490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000079352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF956 family protein"
                     /protein_id="HEV0771009.1"
                     /translation="MAQSLNKTVLLSTTGTSYLSIAGKVGKFLVGDQALEFYPDVNVE
                     QFIQIPWSHINQIGANVTGRKISRHFEVFTDKGKFLFASKDSGAILKIARKKLGNDKV
                     VKLPTLIQTISQKFKNLFAKK"
     gene            44065..45339
                     /gene="serS"
                     /locus_tag="VXE25_000491"
     CDS             44065..45339
                     /gene="serS"
                     /locus_tag="VXE25_000491"
                     /EC_number="6.1.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000884256.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine--tRNA ligase"
                     /protein_id="HEV0771010.1"
                     /translation="MLDIKRIRTDFEAVAEKLATRGVDAAVLNEMKEIDAKRRNILVK
                     VETLKAERNTVSAEIAQAKRNKENTDDKIAAMQNLSAEVKALDAELAEIDAKLTEFTT
                     TLPNIPADSVPVGTDEDDNVEVRRWGTPREFDFEPKAHWDLGEDLGILDWERGGKVTG
                     ARFLFYKGLGARLERAIYNFMLDEHGKEGYTEVITPYIVNHDSMFGTGQYPKFKEDTF
                     ELSDTNFVLIPTAEVPLTNYYRDEILDGKDLPIYFTAMSPSFRSEAGSAGRDTRGLIR
                     LHQFHKVEMVKFAKPEESYEELEKMTANAENILQKLNLPYRVVALSTGDMGFSATKTY
                     DLEVWIPAQNNYREISSCSNTEDFQARRAQIRYRDEADGKVKLLHTLNGSGLAVGRTV
                     AAILENYQNEDGSVTIPEALRPYMGGAEVIKP"
     gene            complement(45360..46262)
                     /locus_tag="VXE25_000492"
     CDS             complement(45360..46262)
                     /locus_tag="VXE25_000492"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000735960.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TDT family transporter"
                     /protein_id="HEV0771011.1"
                     /translation="MKKLPLVFSGCLLGLAGAGNLILDTLPVLSHLFSLTGLVLWIYF
                     LILHLFNWKETKQELTKPPLLSGMATFPMAGMILSTYVFRVFSYLPLVAQGIWWFSFL
                     LDLTLIAGFTIKFACPGRRVHATPSWTVLYVGIAVAALTYPLVGIIEIAYATLSFGFL
                     LTFYLYPLIYSDLKKHPLPLALLGQEGIYCAPFSLLLASLVRVGGTSLPTWVLIVMIL
                     ASQSFFFFVLTRLPNILKQGFQPAFSALTFPTIITATSLKMAQGILKLPFLDYLVLAE
                     TIICLTILFFVLGAYLIWLRKRSS"
     gene            complement(46372..46920)
                     /locus_tag="VXE25_000493"
     CDS             complement(46372..46920)
                     /locus_tag="VXE25_000493"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000206764.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="HEV0771012.1"
                     /translation="MTTFTIHTVESAPAEVKEILETVEKDNNGYIPNLIGLLANAPTV
                     LEAYQIVSSIHRRNSLTPVEREVVQITAAVTNGCAFCVAGHTAFSIKQIQMNDDLIQA
                     LRNRTPIETDPKLDTLAKFTLAVINTKGRVGDEALSEFLEAGYTQQNALDVVFGVSLA
                     ILCNYANNLANTPINPELQPYA"
     gene            complement(47138..48460)
                     /locus_tag="VXE25_000494"
     CDS             complement(47138..48460)
                     /locus_tag="VXE25_000494"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:alanine symporter family protein"
                     /protein_id="HEV0771013.1"
                     /translation="MLELLKSIDAFAWGPPLLILLVGTGIYLTMRLGLLQVLRLPKAF
                     QLIFIQDKGHGDVSSFAALCTALASTVGTGNIIGVATAIKVGGPGALFWMWMAAFFGM
                     ATKYAEGLLAIKYRTKDDHGAVAGGPMHYILLGMGEKWRPLAVLFAVAGVLVALLGIG
                     TFTQVNSITESIQNTTTISPAITALVLSVFVAIAVFGGLKSISKVSTTVVPFMALIYI
                     LGTLTVIFFNIGKIPGTIALVFTSAFSPLAAVGGFAGASVRMAIQNGVARGVFSNESG
                     LGSAPIAAAAAKTNEPVEQGLISMTGTFIDTLIICTLTGLTILVTGVWSGDLNGVALT
                     QSAFSTVFSHFGPALLTIFLVLFAFTTILGWNYYGERCFEFLFGARFIWLYRVVFVLM
                     VLLGGFIELDMVWIIADIVNALMALPNLIALLVLSPVVIAETKKYFDK"
     regulatory      complement(48551..48639)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
     gene            complement(48803..51139)
                     /locus_tag="VXE25_000495"
     CDS             complement(48803..51139)
                     /locus_tag="VXE25_000495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001035046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease MutS2"
                     /protein_id="HEV0771014.1"
                     /translation="MNKKILETLEFDKVKALFEPHLLTEQGLEQLRQLAPTAKADKIK
                     QAFAEMKEMQALFVEQPHFTILSTKEIAGVCKRLEMGADLNIEEFLLLKRVLLASREL
                     QNFYTNLENVSLEELALWFEKLHDFPQLQGNLQAFNDAGFIENFASEELARIRRKIHD
                     SESQVRDVLQDLLKQKAQMLTEGIVASRNGRQVLPVKNTYRNKIAGVVHDISASGNTV
                     YIEPREVVKLSEEIASLRADERYEMLRILQEISERVRPHAAEIANDAWIIGHLDLIRA
                     KVRFIQERQAVVPQLSENQEIQLLHVCHPLVKNAVANDVHFGQDLTAIVITGPNTGGK
                     TIMLKTLGLTQVMAQSGLPILADKGSRVGIFEEIFADIGDEQSIEQSLSTFSSHMTNI
                     VDILGKVNQHSLLLLDELGAGTDPQEGAALAMAILEDLRLRQIKTMATTHYPELKAYG
                     IETAFVQNASMEFDTATLRPTYRFMQGVPGRSNAFEIAKRLGLSEVIVGDASQQIDQD
                     NDVNRIIEQLEEQTLESRKRLDNIREVEQENLKMNRALKKLYNELNREKETELNKARE
                     QAAEIVDMALSESDQILKNLHSKSQLKPHEIIEAKAKLKKLAPEKVDLSKNKVLQKAK
                     KKRAPKVGDDIVVLSYGQRGTLTSQLKDGRWEAQVGLIKMTLEEKEFDLVQAQQEKPV
                     KKKQVNVVKRTSGRGPQARLDLRGKRYEEAMNELDTFIDQALLNNMAQVDIIHGIGTG
                     VIREGVTKYLQRNKHVKSFGYAPQNAGGSGATIVTFKG"
     gene            complement(51243..51791)
                     /locus_tag="VXE25_000496"
     CDS             complement(51243..51791)
                     /locus_tag="VXE25_000496"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000622948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CvpA family protein"
                     /protein_id="HEV0771015.1"
                     /translation="MISFLLLLVLVWGFYIGYRRGLLLQVYYLISAMASAFMAGQFYK
                     GLGEQFHLLLPYANSQEGQGTFFFPSDQLFQLDKVFYAGIGYLLVFGIVYSIGRLLGL
                     LLHLIPSKKLGGKLFQVSAGILSMLVTLFVLQMALTILATIPMAVIQNPLEKSIVAKH
                     IIQSIPITTSWLKQIWVTNLIG"
     gene            complement(51788..52090)
                     /gene="zapA"
                     /locus_tag="VXE25_000497"
     CDS             complement(51788..52090)
                     /gene="zapA"
                     /locus_tag="VXE25_000497"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006150060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein ZapA"
                     /protein_id="HEV0771016.1"
                     /translation="MANLNRFKFTFGKKSLTLTSEHDNLFMEEIAKVATEKYQAIKEQ
                     MPSADDETIALLLAVNCLSTQLSREIEFDDKEQELEELRHKLVTCKQEQSKIEDSL"
     gene            52177..53058
                     /locus_tag="VXE25_000498"
     CDS             52177..53058
                     /locus_tag="VXE25_000498"
                     /EC_number="3.1.26.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000146880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease HIII"
                     /protein_id="HEV0771017.1"
                     /translation="MASITLTPSEKDIQAFLEHYQTSLAPSKNPYIRYFLKLPQATVS
                     IYTSGKILLQGEGAEKYASFFGYQAVEQTSGQNLPLIGTDEVGNGSYFGGLAVVAAFV
                     TSDQHDFLRKLGVGDSKTLTDQKIRQIAPILKEKIQHQALLLSPSKYNEVIGDRYNAV
                     SVKVALHNQAIYLLLQKGVQPEKIVIDAFTSAKNYDKYLAQEANRFSNPISLEEKAEG
                     KYLSVAVSSVIARDLFLENLENLGRELGYQLPSGAGTASDKVASQILQAYGMQGLSFC
                     AKLHFKNTEKAKKRLER"
     gene            53062..53676
                     /gene="lepB"
                     /locus_tag="VXE25_000499"
     CDS             53062..53676
                     /gene="lepB"
                     /locus_tag="VXE25_000499"
                     /EC_number="3.4.21.89"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001048155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase I"
                     /protein_id="HEV0771018.1"
                     /translation="MNSFKNFLKEWGLFLLILSLLALSRIFFWSNVRVEGHSMDPTLA
                     DGEILFVVKHLPIDRFDIVVAHEEDGNKDIVKRVIGMPGDTIRYENDKLYINDKETDE
                     PYLADYIKRFKDDKLQSTYSGKGFEGNKGTFFRSIAQKAQAFTVDVNYNTNFSFTVPE
                     GEYLLLGDDRLVSSDSRHVGTFKAKDITGEAKFRFWPITRIGTF"
     gene            53804..56170
                     /locus_tag="VXE25_000500"
     CDS             53804..56170
                     /locus_tag="VXE25_000500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000454449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent RecD-like DNA helicase"
                     /protein_id="HEV0771019.1"
                     /translation="MEVYFSGTIERIIFENPSNFYRILLLEIDDTDAEDFDDFEIIVT
                     GTMADVIEGEDYTFWGQIVQHSKYGEQLQISRYDRAKPTSKGLVKYFSSSHFKGIGLK
                     TAQKIVDTYGENTIDEILQHPEKLEGIAGLSAKNREAFVSTLRLNYGTEMVLSKLANY
                     GIPNKLAFQIQDFYKEETLDVVENYPYQLVEDIKGLGFTIADQLAEELGIESQAPERF
                     RAGLVHSLFQACMETGDTYVEARDLLEQTLTLLESSRPVELDPGQVAQELSYLIEEDK
                     VQQIDTKIFDNSLFFAEEGIRSHLIRILEKGKQKSQDLETIQKHITTVEQELGIEYDN
                     IQKQAICDAIQNKVFILTGGPGTGKTTVINGIIAVYALLEGLDLRKKSNLPILLAAPT
                     GRAARRMNELTGLPSATIHRHLGMTGDDDTSHLEDYLDADFIIVDEFSMVDTWLANQL
                     FSNISSNSKILIVGDSDQLPSVSPGQVLADLLHIPLIPQTRLEKIYRQSEESTIVTLA
                     SQIRQGILPADFTQKKADRSYFEIASGHIPATIEKILGAALRNSIPAHDIQVLAPMYR
                     GTAGIDAINQLMQDLLNPPQKDQLSFEAPQCHYRKGDKVIHLVNDAEINVFNGDLGAI
                     TDLIPGKYTESKQDEIVIDFDGNEVSYPRNEWYKIRLAYAMSIHKSQGSEFPVVILPI
                     TSASRRMLERNLIYTAITRAKSKLILLGELQAFDYATQHIGTARKTYLIERFSDLLEN
                     VEEKQQAVSETVTSSASEQSYILTEENWDRIPAMIGITDTDLKEIFGK"
     gene            complement(56218..57501)
                     /locus_tag="VXE25_000501"
     CDS             complement(56218..57501)
                     /locus_tag="VXE25_000501"
                     /EC_number="5.2.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trigger factor"
                     /protein_id="HEV0771020.1"
                     /translation="MSVSFENKETNRGVLTFTISQDQIKPELDRVFKSVKKSLNVPGF
                     RKGHLPRPIFDKKFGEESLYQDVMNALLPNAYEAAVKEAGLEVVAQPKIDVTSMEKGQ
                     DWVIAAEVVTKPEVKLGDYKNLEVSVDVEKEVTDADVEERIERERNNLAELVIKEAAA
                     ENGDTVVIDFVGSIDGVEFDGGKGENFSLGLGSGQFIPGFEDQLVGHSAGETVDVIVT
                     FPEDYQAEDLAGKEAKFVTTIHEVKAKEVPALDDELAKDIDEEVETLADLKEKYRKEL
                     AAAKEEAYKDAVEGAAIDTAVENAEIVELPEEMIHEEVHRSVNEFLGNLQRQGINPDM
                     YFQITGTTQEDLHNQYQAEAESRTKTNLVIEAVAKAEGFDASEEEIQKEVEQLAADYN
                     MEVAQVQNLLSADMLKHDITIKKAVELITSTATVK"
BASE COUNT        17039 a        12984 c        10794 g        16712 t
ORIGIN      
        1 aaacaacttc catcacaata gatattttta tcacatattt ttttatagaa cgacaatatt
       61 tgataaaaaa tattttctaa taaaaaaaat aagccataaa actccaccaa tactcattac
      121 tatctttaaa atgcctttta ttacatgctg ttttatcaat aaagtcggaa attccacaac
      181 ctttttgaca agacaattag tttcttttgt attataataa ttaaaattat ctatatgcaa
      241 ctaagattcg gtaactatgc taaacaaata cattgaaaaa agaattacag ataaaattac
      301 cattttaaat atattattgg atattcggtc tattgaacta gatgaactgt ctactttaac
      361 ttcattacaa tctaaaagtc tcctaagcat tttgcaggaa ttacaagaaa cattcgagga
      421 agagttgaca tttaatttag atacgcaaca agttcaatta atcgaacacc attctcatca
      481 aacgaattat tacttccatc agctttataa ccaatcaact attttaaaaa tactccgctt
      541 ctttctacta caaggtaatc aaagctttaa cgaatttaca caaaaagagt atatttccat
      601 cgcaacaggc taccgcgtac gacaaaagtg tggcttgtta ctacgttcag taggtttgga
      661 ccttgtgaaa aatcaagtag ttggtcctga atatcgcatt cgttttttaa ttgcactcct
      721 ccagtttcat tttggtattg agatttatga tttgaatgat ggaagtatgg attgggtcac
      781 acatatgatt gtgcagtcta attctcaact cagtcatgaa ctgttagaaa tcacacctga
      841 cgagtatgtt cattttagca tactagtggc actcacttgg aaacgtcggg aatttccact
      901 tgagttccct gagtccaaag agtttgaaaa attaaaaaac ctctttatgt atccgatttt
      961 gatggaacat tgccaaactt acttagagcc acatgccaac atgactttta ctcaggaaga
     1021 actggattat atctttttgg tttattgttc tgctaattct tcgttttcca aggacaaatg
     1081 gaatcaagaa aaaaagactc atactattca actgattctt cagcatacaa gaggaaagca
     1141 tctactatcc aagttcaaga atatcttagg aaatgacatt tcgaattctc tttctttttt
     1201 aacagcactg actttcttaa caagaacgtt tttgtttggt ttacaaaatc tagttcccta
     1261 ttataattat tacgaacatt atgggattga aagcgacaag ccactgtatc atatttcgaa
     1321 agcaattgtt caagagtgga tgactgagca gaagattgaa ggagttatcg accagcatcg
     1381 gctgtacctt ttctcactct acttgacaga aaccatcttt tcctcactac ctgctatccc
     1441 gatttttatc attttaaata atcaagcaga tgtaaactta ataaagtcca ttattttacg
     1501 gaattttact gacaaagttg cctctgttac aggatacaat attctaatta gtcctcctcc
     1561 ttcagaggag catttgacag agccattgat tattattaca acgaaagaat acctgcctta
     1621 cgttaaaaag cagtatccca aagggaaaca tcactttttg acgattgcct tagatttgca
     1681 tgttagccaa cagcgtctca tctatcagac aattgtagat atccgaaaag aggcttttga
     1741 caaacgggtc gcaatgattg ctaaaaaggc tcactatttg ttataagttc atcgtactgt
     1801 ctacacacaa aaaggggctt cctaagccat ctctattctt atccccatat ttcccagttt
     1861 tgggtaaatc tgaacagaaa aacacttctg ctctctagtt tctgctagtg aacaaaagtg
     1921 ttttttctgg ctctataatt tctgtagtgg gtaaatccca ctgtggagat tatagggctt
     1981 tttgagtatc aaaaaagtcc cataagactt ataatgaaaa gcgcctaaac aactcattag
     2041 aaagtatctt atggaacaca tcaatcatac cacattactc atcggaataa aagacaaaaa
     2101 catcacctta aataaagcca ttcagcacga tacccatatc gaagtcttcg ctacacttga
     2161 ttatcaccca cctaaatgta aacactgtaa aggaaaacaa atcaaatacg acttccaaaa
     2221 gccttctaaa atccctttta tcgagattgg tgctttccct agcctcattc gtttgaaaaa
     2281 gagacgattt caatgcaagt cctgtcggaa agtcactgta gctgaaacaa ctctcgttca
     2341 gaaaaattgc caaatctcgg aaatggtgag acagaaaatt gcccaactcc tactcaacag
     2401 agaggctctt acacatatcg cttctaaatt agccatctct acctctacct ctaccgtcta
     2461 tcgtaagctc aagcaatttc atttccaaga ggattacacc actttgcctg aaatcctctc
     2521 ctgggatgaa ttctcctacc agaaggggaa attggctttc attgctcagg atttcaacac
     2581 taagaaaatc atgaccattc ttgataacag acgtcaaaca accatccgaa atcatttctt
     2641 caagtactcg aaagaagcta gaaaaaaagt taaagtcgtc actgttgata tgtctggaag
     2701 ttatatccct ctcattaaga aattatttcc caatgctaaa attgttctcg atcgtttcca
     2761 cattgtccaa cacatgagca gggctcttaa tcagactaga atcaacatca tgaagcaatt
     2821 tgatgataaa tctctggaat acagagctct taaatattac tggaaattta tcctaaaaga
     2881 tagtcggaaa ctctctctta agcctttcta tgctagaact ttcagagaga ccttaactcc
     2941 tagggagtgt ctgaagaaaa tctttactct agtacctgaa cttaaagatt actatgacct
     3001 gtatcaacta ctcctatttc atctacaaga gaagaatact gaccagtttt ggggcttaat
     3061 tcaagacacg ttacctcatc tcaaccgcac ctttaaaacc actttgagca catttattcg
     3121 ctataaaaac tacatcacta acgccattga attgccttat tctaacgcta aacttgaggc
     3181 cactaacaaa ctcatcaaag acatcaagcg caatgccttt ggttatcgga actttgaaaa
     3241 cttcaaaaaa cggattttca tcgctctgaa catcaaaaaa gaaaggacaa aatttgtcct
     3301 ttctcgagct tagcttttct tcaacccact acagttgaca aagagccctt tttattattc
     3361 aagaacttga ttagctcaat gcatccaagg cgtcatccat tgaaagaact tcgtggaaga
     3421 cacgttgtgt caattcagtt ttttgttctg gagtgaggta tttagtattt acacagtatc
     3481 cagagatacg tacgataacg tcttcacctg acatgatttt ttcgtaaaca tcgttcaagt
     3541 ccataacgtt caagttaacg tgttgtccac cgttttcgaa gtaaccatca aggattgtta
     3601 ccaagttatc aacttgttca tcacgagtct taccaagagc gcgaggtgat acttgtgtag
     3661 tcaatgagat accgtcagct gcataactaa agtcaaggct agaaagtgag ttcaagtttt
     3721 gcaaccaacc acctttagct ttgttagatg ggttagcacc tggtgagaag aattcaagtt
     3781 tagacaagtt cacagaacca tcttcgttga ggtatacacc tttgtgaact ggtgagttac
     3841 cagtttgttt agagtaagca acgttagatg tgattgtcaa aagtgatact gtagcttctg
     3901 cgtctttgta tagtttgtgg ctacgtagac gagttgtgta agcttcgatc aaccattctg
     3961 ccaattcgtt tgaacgtggg tcatcttcac cccagcgtgg gtagtcaccg attgtttcgt
     4021 aatcgtagat gtagccatct tcgtcacgga ttggtttaac tgtagcgtat ttgatagctg
     4081 acaatgtatc aacagtgtta gcaaatccac agataccgaa tcccatgttg gcacgttgtt
     4141 tagttggcaa gaaggccatt tgaacagctt cgtagttgta cctatcagtc atgtagtgga
     4201 tgatgttcaa ggcatctacg taagtgtcag tcaaccagtc aagagatttt tcaaagttcg
     4261 ctttaactga ttcaaattca agaacttcgt cacggattgg ttcgatatca aatactttgt
     4321 agtctttgtg aacatcgtcg taaccaccat tcaaaccagt aagaagggct ttaagaacgt
     4381 ttacacgagc accgaagtac tggatgttgt ggcgttgttc ttcattttct ggatcaagtg
     4441 gagacacaca gcatgagata cagctcattt caccatatcc gtctttagcc attgttgtta
     4501 caccttcgta ttggatagaa gagtgtttgt ggctcatgtg catacagtag cgacggaagt
     4561 tgtatggcaa tttgtcagtc caaagaactg tcaagtttgg ttctggtgag ttaccgatgt
     4621 tgtcaagagt gttcaagaaa cggtagtcca tcttagtaac acggtgacga ccgtcgttac
     4681 ccataccagc catagaagtt gtgataaagg ttgggtcacc tgagtacaat tggtcataag
     4741 cttttgtacg agcaaattta actgtacgaa gtttcataac gaaatcatca acgaattctt
     4801 ggatttctga ttcagtaaat gtaccacgag caaggtcacg ttctgcaaag atgtccaata
     4861 cgattggtac acgacctaga gatgtagcag caccgttaat cacacggcag acagccatga
     4921 aagcaatgtt aacccattgg attgcttctt tcacgttcat cgctggtttg cgaacatcaa
     4981 ccccgtaaag gtcacccagg cgaacaactt gttgcaatgc ttggtattga aggtttactt
     5041 cttcacgaag acggattgtt tcttcatcga tttctttgat tgcattccag tcatttactt
     5101 tttcttgcat caagtagtct gcaccgtaaa gagcaagacg tgcgtaaaca ccgatgatac
     5161 gtccgcgtga gtatgcatct ggaagaccag ttacagtgtg tgcgtgacga gcgcgacgaa
     5221 tatttgaagt gtaggcacgg aaaataccgt cgttaactgt tgttacatat ttagtgaaga
     5281 tttcgtgaac agctgggtct ggttcgtatc cattttcttt caaagtagtt tcagccatac
     5341 ggataccacc ttttggcatg aagttcaatt tgaagagttc atcgttttgg ataccgaaga
     5401 taacttcatt ttctttgtcg ataaatccag cagggatatc agcgatagat gttggacgag
     5461 tgtccattgg gaaacgagtt tcttcgtagt gtgctttagt ttcttctaca attttcttga
     5521 tgtgaagtga acgctctgtt ggtcctgcaa ggaagctttc gtctccatca taaggtgtgt
     5581 agttagcttg tacaaatcgt gatacacttg ctttttcttt ccaatctacg cctttgaagc
     5641 cttcccaagc tttgtcaaaa atatcttgtg cttcaacaac tgtcttaaca accatattaa
     5701 tgtcctcttt tttctagtaa cagtcatctg ttacattcat aagacaagta taccatatag
     5761 taaccgattt caacaagtga aaattcccta tttttacact ttcttttcta aaacagtcta
     5821 tattttattt caaactgtat tatatttttg aaaaaataaa gtcctttttt ctttttttca
     5881 gaaaaaaggg tataataaaa gaaaataagc agtaacactc aatggaaatc gaaaagcaaa
     5941 ctaggaagct agccgcagat tgctcaaaac actgttttga ggttgcagat agagctgacg
     6001 tggtttgaag agattttcga agagtataaa aaggtgctag gcatgttgat ttttcctttg
     6061 ttaaatgatt tgtcaagaaa aatcatccat attgacatgg atgccttttt tgctgcagtg
     6121 gaaatcaggg ataatcctaa actcagagga aaacctgtca ttattggaag cgaccctcgg
     6181 caaacaggtg gacggggagt cgtttctacc tgtagttatg aggcaagagc ttttggtgtc
     6241 cattctgcca tgagttccaa ggaagcttat gaacgttgtc cccaggctgt ctttatctca
     6301 gggaattatg agaaatacaa gtctgtggga ctccagattc gagctatttt taagcgctat
     6361 acagattggt agactaggct atgatctgta tcgaaaggct cgtggcattc acaactctcc
     6421 agtcaaatcc aatcgcatcc gtaaatcaat cggcaaggag aaaacctacg ggaagattct
     6481 ccgtgctgag gaagatatca aaaaagagct gactcttcta tcagaaaaag tcgctctcaa
     6541 tctacatcaa caagaaaaag ctggaaaaat tgtcattttg aaaatccgct acgaggactt
     6601 ttcaactctt accaaacgaa aaagtcttgc tcaaaaaaca caagatgcta gtcagataag
     6661 ccaaatagcc ctgcaactct atgaagaatt aagcgagaaa gaaagaggtg tccgcctatt
     6721 ggggattacc ctgactggat tttaaagctc aatgaaaatc aaagagcaaa ctaggaagct
     6781 agccgcaggc tgctcaaaac actgttttga ggttgcagat aaagctgacg cggtttgaag
     6841 agattttcta agagtataaa accttgaaga gttgcccctt caaggttttt cttatacaaa
     6901 taaacggaca aaactgtaaa gtagcaaaac actaccaagc acgatacggt atttaccaaa
     6961 aagggtgaag tcgtgttttt tcacatagct ggtcaagaag cgaatagcca ccatgctgac
     7021 cgcaaaagct actcccatcg cgaccaagag caaaaacaat tgcccaaagc tcaagagttc
     7081 tccggctttc acaaatttga aaatctttaa ggcactagct ccaaacataa caggaatccc
     7141 aagatagaag gtaaattctg tcacaactga acgactggtt ccatttaaca aaccaccgac
     7201 aatcgttgca cctgaacggc tagtccctgg taaaagagca agaacttgga agagtccgat
     7261 atagaaagcg gtcgtataag gaagcttgtc caactctgtt acacttggct cgatagcacg
     7321 cgctttattg cgcttttcca aatagatgaa ggcaaccccg tagataatca acatgagagc
     7381 aactgaaacc atgttatgga agtgggtatc aaaccaatca tcaaatttaa agacaccaag
     7441 taaaggcaaa gtggcaatca agaccttcaa ccatagtctc caagtcttac gaacttcctg
     7501 tttgtcctta gtcggtttaa aaggattgag cttgttaaaa taaatcacca taactgctaa
     7561 aatagcacca agctgaatta cgacattaaa catggacata aaggcttcat tttgattttg
     7621 gtattggata aactcctctg ctaaaatcaa gtgacctgta ctggaaatcg gcaaccattc
     7681 cgtaattcct tcaacaatcc cgaagaagat agattttaaa atttcaataa gatacataga
     7741 tttctcctta tattatattt aacgcagtta gctactgcca aagcccaagt ggtatacttg
     7801 gaataagcca ctgtggatta gttcatttcc tccaatcgct tgacgatttc cgaaagggtc
     7861 taaccacagc tttttgtttc aattggtaat gagtttgata acgcatagac gttttatctc
     7921 gtctaaggta acaaggcaaa aagttcgtgg ataaccaagt agacttgaaa tactatatct
     7981 ggaggtactc ccatgcttta tgtgggcatt gatgtcgcta aaaataaaca cgatgttaca
     8041 gccttgaatg ttcaaggaaa aactgttctt aaaccactca ctttttcaaa taataaagct
     8101 ggttttgaac tcttagatct gtcttttcga cagctcaacc aagactgtct catcgctctt
     8161 aaacttcttt ctgaccccaa tcgtgaacaa tttcaacacg ataatcggca agtagaacta
     8221 aaaatactgg ctagacatat tcatcgtctc aagaaaaaac agtctgattg gaaagtacaa
     8281 tacactcgtt gtcttgatat catctttcct gagttggata aaatcgttgg aaagcattca
     8341 gaatatacct accaactctt gacacgctac cctaatcctc agaaaaggct tgaggcaaga
     8401 tttgataagc tgatagaaat taagcgattg accgcttcta aaattcagga tatcctctca
     8461 atcgcacctc gttctatcgg aacaacatct cctgctcgtg aattcgaaat catcgaaatc
     8521 atcaaacatt acaagaggct cattgacaag gcggaaacat gtgtcaatga cttgatggct
     8581 gagttcaact cggtcatcac gacggttact gggattgggg gtcgtttagg ggcggtcatt
     8641 ttagccgaga ttcgaaatat tcatgccttt gataatcctg ctcaattaca agctttcgct
     8701 ggactggatt cttctattta tcagtcaggt cagattgatt tagctggaag aatgatcaaa
     8761 cggggttccc ctcatctgcg gtgggcactc atacaagctg ccaaagcatg cgctcgcttt
     8821 tcacctgctt ttaaggccta tcttaagact aagttagaat aaggaaaaca ttacaatgta
     8881 gccatcatcc accttgcaaa aaaacttatc cgaaccctgt tttatatcct aaaaaagagc
     8941 tgccatttga cgaacaaaaa gtgatgtaat ttctgaaatt aacacaggat tacctttgaa
     9001 aaaatggact ttttcaaggg ctttttgccg tgctctaaaa tcatcgccaa atcatcaaat
     9061 tgaaataaga aatagtttag ataaaactat tgacttttct tatagtttgt ctttcttcta
     9121 tcttccatta tatcatactt tttcagtcta tggtagctct ctttaaaagg ctccgatact
     9181 gccgccacct ccgcctccag agaagccacc gccagaactt ccacttccag aagatacgga
     9241 gtaggtactt gctgtatttg cgacactagc ataatggctc atttgcgcgc ttgaatgata
     9301 aaacatactg tgccagccat aagctacata gagattgata tctggatttt caacttgaat
     9361 ctgatgaacc ttcatcaaat gactaacctt gtccgcatag ccaaataagg ttgcatagac
     9421 caagagacga ttccaaacaa caatactttc caattcagcc ttatccagtc gtgcaatctc
     9481 acgtaacata ttttcaaaac tggtccagag atagtagacc tcagctcccg cttcatttag
     9541 aacaccatca cgattatcta gtcgaagctt ccaataatag aaaacagaca aaactaaccc
     9601 tagaaaacca agtattggca aagggaggta aagatagcca tgaacgtcta aactgtacaa
     9661 gaacaaacca aatccgataa ataggggcag gatagtcaag gcacccatac ccacttgcaa
     9721 ggccttttcc ccaccagtta aaggacgata ataatctggg agcccccaga aggaaactcg
     9781 ttttctcact ccttcttgca tctggttcaa tacctcttca aaagaagatt tgagttgaag
     9841 ccctcttgct tgaatccgtt tttcatcaga aactttggct ctacgataaa gactatcaga
     9901 taccttgtaa tccgcaaaca aattggaaag agtttcttct tttttacctg aaaaagctag
     9961 atttaggcag tctctctcaa agcttgacaa accatcttct tttactagcc tcaaaccaac
    10021 tgcatctcct tctgaaataa tagaaacatt cccacggtcc atcacatcta gcaaggtagc
    10081 ttgaataagt tggtcaaaag tgaatttgcc agcccccttg actaagggac tcacttcctc
    10141 caaggaggtc gagtagacag cctctgataa aaccataggc tctaattcca ttggtggttc
    10201 atagagacga tgatttttgg catatttgac tgaaggagtg gtctttcttc tataaataaa
    10261 atagaagcag acactcaata acaaggagat agaaaggatc gaagggagga cccaagtaac
    10321 aagttgttta ctctgatctt tttctctaac aatcgagtct tctatcttat taaactcttc
    10381 taaacgattc cctttcaatc cctgatccct agcgctagca aaatcggtcc gaggccagta
    10441 ggcatgcaac tcaactccac gcttagccgg aagattgtct aaacggatag tataatcaag
    10501 gttactcttt tcaatcgttc cctctctaaa aagtttccct gtatggaaaa agagtttttc
    10561 agcccccttg tctcccctta catgaaattc aaacttttca atagactctg aactatctgt
    10621 cagaggttgc caatttaatt cagcgatatc atcataaagg aaaagtaaat tttttaagtt
    10681 ccagacgagg tcaacttcaa ctatgtcgcc ctcctgacct ggattataga ctctcacagt
    10741 ataaccatcc gcttcttctg ttacttcgct agtcacatct gctagttctg caccgttttt
    10801 cgcggcctga acctttggat gagggtcaat gtcaaacccg ctaggcatct taccagcacg
    10861 tccaagtccc acgatttgtc ccttaaagtc ctcctcaaac tggtaaacta tcttctgtct
    10921 aaactctgcc gtattatctg catgaatata caaatcccct tgataagagt ttatcttgaa
    10981 atcaatggca aaaacagaga gtggaagaag gcaaaacaag cctaacacca gtaagaaaaa
    11041 agtttttttc atcaactaag cccccttttt atctttctta tcattatagc attttttcgt
    11101 aagtaaaggc ttacttatgt tgaaaaatta cgcatttttc gataaaatag gagacagtta
    11161 ttttttaata gatcagaata ggagaaatca tgagaaaaat atacttatct attttcacaa
    11221 gtctcttgct gatgctagga cttgtcaatg ttgctcaagc cgatgaatat ttacgcatcg
    11281 ggatggaagc agcatatgct ccctttaact ggacccagga tgatgatagc aacggagctg
    11341 tcaaaatcga tgggaccaat cagtatgcca acggatacga tgttcaaatc gccaagaaaa
    11401 tcgctaagga cttaggtaaa gaacctttgg ttgttaaaac caagtgggaa ggtctagtcc
    11461 ctgcccttac ttctggtaag attgacatga ttatcgcagg tatgagtcca actgcagaac
    11521 gcaaacaaga aattgccttt tcgagcagtt actacactag cgaaccagtt ttgcttgtca
    11581 aaaaagattc tgcctacgca agtgctaaat ctttggatga ctttaacggt gcaaaaatca
    11641 cttctcaaca aggggtctac ctctacgact tgattgcaca aatcccaggt gctaaaaaag
    11701 aaacagccat gggagacttc gctcaaatgc gacaagctct tgaggctggt gtcattgatg
    11761 cttatgtttc tgaacgtcca gaagcactga ctgctgaagc tgcgaactct aagttcaaga
    11821 tgattcaagt agaacctggt ttcaaaactg gggaagaaga tacagctatc gctatcgggc
    11881 ttcgtaaaaa tgacaatcgt attagccaaa tcaatgccag cattgaaacc atttcaaaag
    11941 atgaccaagt tgccttgatg gatcgtatga tcaaggaaca acctgccgaa gctacaacaa
    12001 ctgaagagac tagcagtagt ttctttagcc aagtcgctaa aattctttct gaaaactggc
    12061 aacaactctt gcgtggtgct ggtatcactc ttttaatctc tatcgtcgga accatcatag
    12121 gtctcattat tggacttgcc attggtgtct tccgtactgc tcctctctct gaaaacaaag
    12181 ccatttatgg ccttcaaaaa ctagtcggct gggttctcaa tgtctacatt gaaattttcc
    12241 gtggtacgcc aatgattgtt caatcgatgg ttatctacta tggaactgcc caagctttcg
    12301 ggatcaacct tgaccgtaca ctggctgcta tcttcatcgt ttcaatcaat accggtgcct
    12361 acatgactga aatcgtccgt ggtggtatcc tagcagttga caagggacaa tttgaagctg
    12421 cgactgctct tggtatgacc cataaccaga ccatgcgtaa gattgtccta cctcaggtag
    12481 tccgtaacat cctacctgca actggtaatg aatttgtcat caatatcaaa gatacatctg
    12541 tattgaacgt tatctctgtt gtcgaacttt atttctcagg aaataccgtg gcaacacaaa
    12601 cctatcaata cttccagaca tttacaatca tcgccgtgat ttactttgtc ctcaccttca
    12661 ccgtaacacg tatcctacgc tttatcgagc gcagaatgga catggatacc tacactacag
    12721 gtgctaacca aatgcaaacg gaggatttga aataatgaca caagcaatcc ttgaaattaa
    12781 acacctcaaa aaatcctatg gacaaaacga agtgctaaaa gacatttcac tcactgtcca
    12841 caagggagag gtcatctcta tcatcggaag ctctggaagc ggaaaatcga ccttcctacg
    12901 ctccattaac ctacttgaaa caccaactga tggacaaatc ctttatcatg gacaaaacgt
    12961 cctcgaaaaa ggctatgacc tcacgcaata ccgtgaaaag ttggggatgg ttttccaatc
    13021 ctttaacctc tttgaaaatc tcaatgttct tgaaaacaca atcgtcgctc agacaactgt
    13081 cctaaaacgc gaacgcacag aagctgaaaa gattgccaaa gaaaacctgg aaaaggtcgg
    13141 catgggagaa cgctactggc aagccaaacc aaaacaactc tcaggtggtc aaaaacaacg
    13201 tgtggccatc gctcgtgccc tctccatgaa tccggacgcc attctctttg atgaaccaac
    13261 atcagctctc gatccagaaa tggttggaga agtcctcaaa atcatgcagg acctggctca
    13321 ggaaggcttg accatgattg tcgtaaccca tgaaatggaa tttgcccgtg atgtctctca
    13381 ccgtgttatc tttatggata agggcgtgat cgctgaagaa ggtaaaccag aagacctctt
    13441 caccaatcct aaagaagacc gaacaaaaga gttccttcaa cgctatctca aataaaaaga
    13501 aaaggctgca tcaaccgtgc agtctttttg ctgtcctcaa aatgaaaagg cagattctct
    13561 atctctacta cttgaaggtc aagaatccgc cgttatccaa agattaatct tcaaattttt
    13621 cataattttt ttcatagaaa tcaattaggc ctagggctgt ttcaaatgaa atatttttta
    13681 cttttgcacg accctgcgcc agagcaatga tagacatttc acgcgcattc gtttctttag
    13741 agatacggta gcctgtgatt ttcttatcac gaacccagcc aacaactgat tctacttttt
    13801 caaagtttga cttagccatg tttttctcct attttcttct ttataatatt taattgtata
    13861 cgtttttact acttttgtca ataaaaaaaa catatattca acgaaaataa ttagttcaga
    13921 attttcttac ttccttttta aatccgataa tatataggtt ttgctagcct ctacaccata
    13981 aatatttgct aataaaacta ctgtattatt accctcttaa ggtgcgaaat tattcaagtt
    14041 cttaaaaaat gcttctctat ttccgtaaga tagcttattt cttcgattta agaactgaag
    14101 atgatagttc taacctttag aaatccaagc cttcactagc tcaaaaactc ctatctttct
    14161 tcctcaataa atcatctgag agataggtat tccttatatc cttcaaattc atcactcctt
    14221 tggatattga ggtgctagcc tagaagcaga cacccgatta tctaaaccat ccttaataga
    14281 gatgacaaga cagataagct cagttaatta cttatatatc tttttaatat ggtatatttg
    14341 tcaacaaaaa gaaatcaaat cataccttat actcaatgaa aatcaaagag caaactagga
    14401 agctagccgc aagttgctca aaacactgtt ttgaggttgc agatagagct aacgtggttt
    14461 gaagagattt tcgaagagta ttaaagacag tgtgactatg cttgtcaata gataggaaat
    14521 caaaatgaag gatggaaatc tgagccaaac atcataagtg ctataatgaa cagaagtaag
    14581 aattgcacga taagttttct aaaaccatag gaatcgtccc ctttcttcat cttcattata
    14641 gcacatatac atcagttgta caaataatat gatatttttt tattagtcct cagacaagca
    14701 tattataaag cgtttcatta ccatttaagt taatataagc tggatcaaaa ccttccattc
    14761 tacgaatcaa acctgcataa tcatgcttat ctgctaaagc gatcccaatt aatactgggc
    14821 ctgttccctt gctagctcgt ttgatatact caaaacgtgt gatatcatca tttggcccca
    14881 ggatatcatt tacaaactca cgcaaagctc ctggacgttg tgggaaattg accacaaagt
    14941 aatgtttgat accatcataa atcaaggcac gctcttccat ttctggcata cggttgatat
    15001 cattatttcc tccagaaatg atacaacaaa tggttttccc cttaatatat tcagctaaaa
    15061 cctctaaaga ggcgatacta gccgctccag caggttctgc gactatccct tgcttagagt
    15121 aaaggtcaat caaggtttca gaaatcaatc cctcatcgac acctaccaaa gttttaatat
    15181 gttgacgagt tgcttcatag gtcaactgac ctaccttttg cacagcaatc ccatccgcaa
    15241 atttatcaat ttccttgagt ttgactggac ctccagcctc aaaggcagct ttcatggaac
    15301 gcgctccatt cgcctctact ccgataacct caatctctgg acttgtttcc ttgatatagg
    15361 tagaaacccc ggcaatgaga ccgccaccac caacaggaac caagacagca tcaaaatcaa
    15421 tcgattcttt tcgagcttct tctaaaatct cataagcaac tgttccttga cctgcttgaa
    15481 catgagcatc atcaaaagga tcaataaagg tacgattttc agagactgta aattcttgag
    15541 ctgctttggc tgaggcatca aaggtatctc caactagttt aatagttaca aaatccccac
    15601 caaaaaagcg aacctgacca atcttttgtt gtggcgtagt aataggcata aagatagtag
    15661 caggaatttt catttcatta caagtatagg ctactccctg cgcatgattt cccgcagaag
    15721 cgcagactac cccacgttca cgttcttcct tgctgagctg ggaaatggca taataggcac
    15781 cacgaatttt aaaggagcga acacgctggg cattttcttt tttcaaataa atcttagcac
    15841 catacttctc cgataaataa tgatcgtaat ccagtggagt attcacaacc acaccgttca
    15901 agaccttgtg agccttgatt atatcttttg aacttaacat ataaaacctc tttttctata
    15961 aaaaacagtc actaatgact gttttttagt tattcatctc cgaaaacttc agtaacactt
    16021 tcatggtatt tatgagccat acgaatcgaa aactctttag gaagttcata acgatttgtg
    16081 gaaatccaat catataacca ttctaccaaa ctttcttcac tatcattacg atggaagata
    16141 aaatagttta aaatttcttt atattctaca tcattcaaat ccaacgtgtc tacaaattga
    16201 ctacgaggaa caaaattaga atctaatttt cttagttgat ctgtcaattc tcccaattgt
    16261 aaatccaact gaaaaaatag tttttgcagt tgcctatcag tttcatcaca tcctgtcttg
    16321 atagaaaaca aattggtaat attcatatga tttcaacccc taaataagta catctaatat
    16381 cccacgaata gctgaagcta aagttttcgc agtccagtca tttaaacccg attctttcaa
    16441 tccagatgca ataatttgct ctatttgata taaaccgcca tctatcgtct catttattct
    16501 gcgaagagga ccttcaatat aggataaagc ttctccgaat ctaacagctg atttaggtcc
    16561 taatgattta ccaactatat ttgttaatgt tttttatttc tcaaaatcca tttcgctata
    16621 taacgagcag atttagtcgc accagctctc tcaaacggag aatgaatttc aagaccttct
    16681 tctctagcta tttgtgccaa tttgaagaat tgttcaaagg tcatatgcaa cctaccatct
    16741 tcaaaattag catcatcata aatgttaatt acagcatttt catcatacga ccaatctgct
    16801 ttattttggt ctgctagcac tattaccgac ggtgtaatta cattatacaa ctagaaccaa
    16861 taataacgat gcaatttttc tcataatctt tttcataaaa tcatctccag cgctatatat
    16921 ttctaattag ttatagattt tgaatgcatc atcgtcgttt ttaccaacga atggcattgc
    16981 tttacgcaat tctgcaccaa ctttttcaat ttcaaggtta gctgcttgtt cacggtaagc
    17041 agtcaatttt ggacgtccag ctttatagtc atttacaaag tcatttgcaa atttaccatt
    17101 ttggatgtct gccaagacag ccttcatatt ttctttaact tgttcagtga ttacacgtgg
    17161 acctgataca tagtcaccgt attcagcagt gtttgaaata gattgacgca ttttcttgaa
    17221 tccaccttca tagatcaagt caacgatcaa tttcatttcg tgaagaactt caaagtaagc
    17281 caattctgga gcgtaacctg cttctgtcaa gacttcgaaa cctgcttcga taagggcagt
    17341 caaaccacca caaagtacag cttgttcacc aaacaaatct tcttcagttt cttctttgta
    17401 agttgtttca agaagaccta cacgagccgc tccaacacct ttacaccagt ccatagcaat
    17461 gtttttagca tttcctgttg catcttggta tactgcataa agagctggaa caccaaatcc
    17521 ttcttcgtaa gtacgacgta ccaagtgtcc tggtccttta ggagcacaca tgaagacatc
    17581 tacatccgca ggaactttga taaattcaaa gtggatgttg aaaccatggg caaatccaac
    17641 tgcgtttcca gcttccaagt ttggagcgat ttctgcttcg tacaattctt gttgaatttc
    17701 gtctggcgcc aagatcatga taacatcagc caacttagta gcttctgcta ctgtgtaagt
    17761 atcaaatcca tcttcttttg ctttatcaaa agatttacct ggacgtacac ctataataac
    17821 gtcacgacct gaatcacgca agttttgagc atgcgcatgc ccttgtgaac cataaccgat
    17881 aacggcgatt tttttaccgt caagtgctgc tactttaaca tctttttcat attccatttg
    17941 aactgtcata gcttttctct cttttctatt atttattgcc ttttaggctg gtttaataaa
    18001 tttaagttgg atttttaatc gcgggtaaat ccagttgcac ccgttcgagc aatattgcga
    18061 ataccgtatg ggcgaatgac tctcaatagg gcttcgctct tttctgcatt tcccgtcatc
    18121 tgaatggtaa tcgagcttgg cgctacgtct accactgttg cacggaaagg ttgaataatc
    18181 gctaaaatct cagctctctt ctcagctggc gctgacatct taaccaaaat cacctcgcgc
    18241 tccaaatgag gcttgtctgt aatatctcga atgcgaatca catcaatctg acgattgagc
    18301 tgtttgatga tttgctccac ttcatcatga gaagcaacat caataataat agtgatacgc
    18361 gatacattcg gatcttctgt tgctccaaca gagatgcttt caatattaac ctgacgacga
    18421 gataggacac ctgtaaagcg attgaggact cctgaacgat tttgtagttt tgctgttaac
    18481 attctacgca tggaactgca cccccaacat ctcatgatta ctcttaccag ccggtaccat
    18541 tggtaacacc tgttccttac gagaaatatc tacctcaatt agcataggaa catcctcagt
    18601 gatgacttca aggtcttgag ccaaggtctc aggattgtca aacttatagt ttttaatgcc
    18661 ataagcctgc gccatcaatt ggaaatcagg aagggtatca aagaccgact ctgatgttct
    18721 gccttcatag aaggattcct gccactggcg aaccattccg agtgaatgat tgttcagcat
    18781 aaccaccttg attggcacct tgtaaatatt caaaatagcc aactcctggt tagtcatttg
    18841 gaaaccacca tccccaacaa acaagactac ttccttatct gggttagcaa ttttagcacc
    18901 gattgctgct ggaattccaa agcccattgt tcccaaacca cctgaagtca ctaactgacg
    18961 ttcattttgg tagggataat actgagctgt ccacatttgg tgttgaccaa cgtctgttac
    19021 cacaatggca tctccattcg tcaattcacc aattcgttca ataactgctt gcggttgaac
    19081 cacacgctct ttcttgtcat aagaacgaac acgattcttg tctttagtga ctttctcaat
    19141 ccacttttca gtattgttgt gaactgttgg ttctgctagc aacatttgca aggccttctt
    19201 agcatctcca actacaggaa tgtctgcact gataatcttg ccaatctcag ctgggtcaat
    19261 atcaatgtgg gcaaccttag cattcttagc gaaagtctta ggattccccg tcaaacggtc
    19321 atcgaaacga gaaccaatac taatcataaa gtccgcttcc gtcatggcaa tatttgctgc
    19381 gaatgacccg tgcatgcctc ccattccaag aaagagtggg tgactcgttg caatcgttcc
    19441 ttgtcccaaa agactggtta ccactggaat ttgatagcgt tctgcaaatt catttagttc
    19501 cgtagcagcc tcagcataac taattccacc accagctaac aagactggct ttttagcctt
    19561 ggacaattgc ttcaagattt tcttgatttg catatcattc ggctcaagag tcggctgata
    19621 acttggtaaa ttcacttctg gtgaataaat gaagtctgtt tctaaagcag atatgtcttt
    19681 tggtaggtca attacaactg gccctggacg gcctgtagtt gcgatatgga cagcttccgt
    19741 aatgatacgc ggaatatcag ctgtctcacg aacttggtaa ttgtacttag tgattggcat
    19801 ggtaattcct acgatgtctg cctcctgaaa ggcatccttc ccaatccctg ctcgcgccac
    19861 ctgacctgta aagaccaaaa ggggaacgct atcgctcata gcatccgcaa tccctgtaat
    19921 ggcatttgtt gctcctggtc cactagtgac gacggcaaca cccaactttc cagttgattt
    19981 ggcataacct tcagcttcat gcaaacaacc ttgctcatgg cgccctagaa tgtggcgaat
    20041 gcctttaaaa ttatatatcg catcataaaa aggcaaaacc gcaccaccag gataaccaaa
    20101 gatggtatca actcctaaat cacgaagtgt ttccaaaact aggtccgacc ccgtcttagg
    20161 agattctaaa ctgattttct ccattgttcc cctttctttc ctcttaaaaa taacttgtta
    20221 ctatcatacc attttttcaa aatttttcaa gataaaagaa gaaattttct gaattttcta
    20281 ttttaacgtt tatttatgaa tgttattttt gtttttatta aaaagatacc gatttcattt
    20341 actaaaaaag aaaaaagaac tgatttctca gtccttcatt aatcttattc cacactaaat
    20401 aggtatgggt aaacaggttg ttgaccttgg tgaatctcga cttcaacgtc ttcgaattct
    20461 tctacgattt cttgagcgat ttcattggca agttcttcgc ttccgtcttc accgacatag
    20521 aaggttacga tttcactgtc ttcatccaac atatgtttca aggtttcagt caatgtttgg
    20581 tgcatatcag ggtttgacac aagaattttt ccatccacca tacctagatt atcgttttca
    20641 tggatttcta agccatcgat cgttgtatca cgcacggctg ttgtgacgct tccgctaacg
    20701 acatctctaa gagcagctgt catacgctct tggttttctt caatggactt gcttggatca
    20761 aaggcaagaa gacttgtcat accttgagga agagtgcgag cctctaccac tactgctggt
    20821 tgctccaaaa cttctgccgc agattgagct gccatgaaga tgttcttgtt gtttggcaag
    20881 aagatgatgt tacgggcatt gacctgttca acagccttga taaagtcttc tgttgaaggg
    20941 ttcatggttt gaccgccttc gataacataa tccacgcctt gagaacagaa gatatctgct
    21001 agacctttac cagccaccac agcaatcaaa gcatactctt tttcttcagc cgacttgata
    21061 acttgagtag cttctttctc aacctgtgct tcgtgttggt tacgcatatt gtcaactttt
    21121 accttgacca agctaccata tttgagacct tcttgcataa caagtcctgg atcttctgta
    21181 tgaacatgga ctttgacaat ttcatcatcg ttaacaacga ggagagaatc cccaagctca
    21241 tccaagtagt tacggaattc atcgtagtca aaatctttag cataggttgg accttgctta
    21301 agagctacca tgatttcagt acagtaacca aacgtgatgt cctcagtcgc tacgtgacca
    21361 gctacagact tatgatgctc tacattgatc atctcactca tgttggcagg agtcgctaca
    21421 aagtcctcag atgcaatata ttcgccagta agggctgaaa ggaaaccttc gtagatgaag
    21481 accaatcctt gaccacctga gtccacaacg ccaacttctt tcaatactgg aagcatgtct
    21541 ggtgttttag ctagagctgt tttagcacct tccaaggctg cgcgcatgac ttcaacagta
    21601 tcatctgttt gctcagcttt tttcttagca ccgatagcag ctccacgaga aactgtcaaa
    21661 atcgttcctt caacaggttt catcactgcc ttataggcaa cttccacacc tgattggaag
    21721 gccagagcca agtcttgacc tgttaactcg tctttatcct tgatagcttg ggaaaatcca
    21781 cggaaaagct gagacgtaat cactcctgag ttcccacgcg cacccatcaa aagcccttta
    21841 gcaagaatgc tcgctacttc tccaactgta gaagctggct tgtctgcaac ttctttagca
    21901 ccattttcaa tggtcattcc catatttgtc ccagtatctc catctggaac tggaaagacg
    21961 tttaatgaat tgacatattc agcttgctta ttcaagcgag ttgatgcagc ctgcaccatt
    22021 tcttgaaata agctagtagt aatttttgac acggttattc tcctacaact ttgatatttt
    22081 gaatgtagac atttacagtc tgagcagtaa ttccaagctg gttttccaag ctaaaggcaa
    22141 cacgctcttg aatgtttttt gacacttcac taatctttgt tccgtagctt aacacggtat
    22201 atacatcaac tgcaatactg ccatcttcgg ctgcctttac gacgacacct ttagaataat
    22261 tttccttacc tagcagggct tggaaattat ctttgagggc atttttacta gccataccga
    22321 ccacaccaaa aatctcagtt gctgctccac ctacgacggt tgcaatcact tcatctgtta
    22381 gttcgatttg accatctttt gtattaattt ttacagtcat cctttttacc tcaactagtt
    22441 gatactctat tttatcatat ttcagcccaa gtgtaaaagc agaatgatgt atcagcggat
    22501 atttactcta tttttcaaac gatgttatac ccacaataaa agaaaaaaga ccctaaggtc
    22561 tcctttgctt ttattattaa acgcgttcaa ctttacctga tttcaaagca cgagctgaag
    22621 cccaaacttt tttaggttta ccatcgataa gaacagtaac tttttgaagg tttggtttta
    22681 cggcacgttt tgtttggttc atcgcgtgtg aacggttgtt tcctgataca gtcttacgac
    22741 ctgtaaagta acatacttta gccattgtgt tttcctccta ttagatctaa tatagcggat
    22801 gtgctagcac cacataccgt actatgttat cacactttct tgttttttgc aagggaattg
    22861 gaagattttt tatttgtgtc ttaaatcagg tcttgcgtga cattttctgc tctccacatg
    22921 ccattgttga ttaacagaac accagaatta aaattatgtg tataaaaatc atctctaact
    22981 gcagctaagg gtatagccgt caagtccaaa tcccacagct catctatcga ttttcttaca
    23041 acaatatcta aatccaaata cagtacacga gactcgctta catactttgg aataaaatac
    23101 ctaaaaaagc cgcatatgaa agtccctcaa aggggagacg ataacctttc agaatactac
    23161 tgtcaatcta aacattcaca atctcactat tcaaagtctc tagtcttttt tccatcaatt
    23221 ggaaccattc tcgcggaagg tcatcattaa aaacataaaa cttaagatta taatagatga
    23281 acacaaagag attttattgt tgtttcaact ttatccatat aagcattatc tgcacctaag
    23341 acaatcgctt ttttctcttc tttcactctt tatctcattt ctttttattc ccatcatatg
    23401 tttctacgta accattattt tcgcccattc gttcgtaaaa ccataccagt ggagatttta
    23461 gatgaagtcc cattacggtt tacaattttt acattacgac acggagtttt acaaatcgat
    23521 ttcatttgcc aaacgtagtt agtaaggcag ttagctagtt cgccaaatag cgactagcgt
    23581 ccaacaattt ggaactttag ttccaattgt tggtactgag tcacatcttc tcctctaact
    23641 ctacgtctgg atacttgtcc gcaaaccagc ggagggcaaa gtcattttca aagagaaaga
    23701 ctggttggtc aaaacggtct ttggctaaga tattgcgact tgacgacatc cgttcatcca
    23761 agtcctcagg cttgatccaa cgaacggtct ttttacccat tgggctcatg accacttccg
    23821 cattgtattc gccttccata cggtgtttaa agacttcaaa ctggagttga ccaacagctc
    23881 ccagcatgta ctcacctgtt tggtaattct tataaagctg aacggctcct tcttgcacca
    23941 attgctcaat ccccttgtgg aaggattttt gcttcataac attcttagca gaaactttca
    24001 tgaaaatttc aggagtaaag gttggcagtg gttcaaattc aaacttgttt tttccaaccg
    24061 tcaaggtatc cccaacctga taagtaccgg tatcgtaaac cccgataata tcacctgata
    24121 cggcattggt cacattctca cgactctccg ccataaactg ggtaacatta gatagtttgg
    24181 cacccttacc agtacgaggg agattgacac tcatgccacg ctcaaattcg cctgatacga
    24241 tacggacaaa ggcaatacgg tcacggtgac gaggatccat gttggcttgg attttaaaga
    24301 caaagcctga gaaatccttg tcataaggat ccacaatttc accgtctgtt ttcttgtgac
    24361 catgtggttc tggagcaaac ttgaggaaga tttcaaggaa ggtctgcaca ccaaagtttg
    24421 tcagggctga accgaaaaag acaggcgtca attctccagc cagaatagct tcctctgaaa
    24481 actcattccc agcttcattt aaaagctcaa tgtcatcctt gacttgctcg tagaaaggat
    24541 tgctaccaaa gagtttgtcc ccgtcttcta gactggcaaa acgctcatcc cctttgtaaa
    24601 gctctaaacg ttggttatag aggtcataca agccctcaaa ggctttcccc atcccgatag
    24661 gccagttcat agggtagcta gcaatgccca agatttcttc caattcttgc aagagatcca
    24721 aaggctcacg accgtcacgg tccagcttgt tcataaaggt aaaaactgga atgccacgat
    24781 gtttcacaac ctcaaacaat ttcttggttt gagcctcgat ccccttggca gagtccacga
    24841 ccatgaccgc agcatccacc gccatcaagg tacgataggt atcttctgag aagtcctcgt
    24901 gccctggcgt gtctaagata ttcacgcgct tgccgtcgta gtcaaattgc ataacagatg
    24961 aagtaacaga aatcccacgt tgcttctcga tatccatcca gtcagattta gcaaaagtcc
    25021 ctgttttctt cccttttacc gtaccagcct cacgaatctc acccccaaag tagagtaact
    25081 gctcagtgat ggttgttttc cccgcgtccg ggtgggagat aatggcaaag gtacgacgtt
    25141 tcttaatttc ttcttgaata ttcataagtt ctctttcttt gattctctat ttttcttgtt
    25201 tcaatagctg agaatgattt ttacattgga ttttaccatt cctttcaaca ttccattata
    25261 tcggatttta gcattttttt caatttctat ttcttttcac ttccccctcc cttatttata
    25321 ggaaaatatg gtaaaataga acagactaaa aatcatcatt tcacgaaagg atgcaagatg
    25381 aaaattacgc aagaagaggt aacacacgtt gccaatcttt caaaattaag attctctgaa
    25441 gaagaaactg ctgcctttgc gaccaccttg tctaagattg ttgacatggt tgaattgctg
    25501 ggcgaagttg acacaactgg tgtcgcacct actacgacta tggctgaccg caagactgta
    25561 ctccgccctg atgtggccga agaaggaaca gaccgtgatc gcttgtttaa aaacgtacct
    25621 gaacaagaca actactatat caaggtgcca gctatcctag acgatggagg agatgcctaa
    25681 tgacttttaa caataaaact attgaagagt tgcacaatct ccttgtctct aaggaaattt
    25741 ctgcaacaga attgacccaa gcaacacttg aaaatatcaa gtctcgtgag gaagccctca
    25801 attcatttgt caccatcgct gaggagcaag ctcttgttca agctaaagcc attgatgaag
    25861 ctggaattga tgctaacaat gtcctttcag gaattccact tgctgttaag gataacatct
    25921 ctacagacgg tattctcaca actgctgcct caaaaatgct ctacaactat gagccaatct
    25981 ttgatgcgac agctgttgcc aatgcaaaaa ccaaaggcat gattgtcgtt ggaaagacca
    26041 acatggacga atttgctatg ggtggttccg gtgaaacttc acactacgga gcaactaaaa
    26101 acgcttggga ccacagcaag gttcctggtg ggtcatcaag tggttctgcc gcagctgtag
    26161 cctcaggaca agttcgcttg tcacttggtt ctgatactgg tggttccatc cgccaacctg
    26221 ctgccttcaa cggaatcgtt ggtctcaaac caacctacgg aacagtttca cgtttcggtc
    26281 tcattgcctt tggtagctca ttagaccaga ttggaccttt tgctcctact gttaaggaaa
    26341 atgccctctt gctcaacgct attgccagcg aagatactaa agactctact tctgctcctg
    26401 tccgcatcgc cgactttact tcaaaaatcg gccaagacat taagggcatg aaaattgctt
    26461 tgcctaagga atacctaggc gaaggaattg atccagaggt taaggaaaca atcttaaacg
    26521 cggccaaaca ctttgaaaaa ttgggtgcta tcgtcgaaga agtcagcctt cctcactcta
    26581 aatacggtgt tgccgtttat tacatcatcg cttcatcaga agcttcatca aacttgcaac
    26641 gttttgacgg tatccgttac ggctaccgcg cagaagatgc gactaatctt gatgaaatct
    26701 atgtaaacag ccgtagccaa ggttttggtg aagaagtgaa gcgccgtatc atgctgggta
    26761 ctttcagtct ttcatcaggt tactacgatg cctactacaa gaaggctgga caggtccgta
    26821 cacttatcat tcaagatttc gaaaaagtct tcgcggatta cgatttgatt ttgggtccaa
    26881 ctgctccaag tgttgcctat gacttggatt ctctcaacca tgacccagtt gccatgtact
    26941 tagccgacct cttgaccata cctgtaaact tggcaggact gcctggaatt tcgattcctg
    27001 ctggattctc tcaaggtcta cctgtcggac tccaattgat tggtcccaag tactctgagg
    27061 aaaccattta ccaagctgct gctgcttttg aagcaacaac agactaccac aaacaacaac
    27121 ccgtgatttt tggaggtgac aactaatgaa ctttgaaaca gtcatcggac ttgaagtcca
    27181 cgtagagctc aacaccaatt caaaaatctt ctcacctact tctgcccact ttggaaatga
    27241 ccaaaatgcc aacactaacg tgattgactg gtctttccca ggagttctac cagttctcaa
    27301 taaaggggtt gttgatgccg gtatcaaggc tgctcttgcc ctcaacatgg acctccacaa
    27361 aaaaatgcac tttgaccgca agaactactt ctaccctgat aatcccaaag cctaccaaat
    27421 ttctcagttt gatgagccaa tcggttataa cggctggatt gaagtcgagc tagaagacgg
    27481 tacgaccaag aaaattggta tcgaacgcgc ccacttagag gaagacgctg gtaaaaacac
    27541 ccacggtaca gacggctact cttacgttga ccttaaccgc caaggggtac ctttgattga
    27601 gattgtatct gaagccgata tgcgttcgcc agaggaggcc tatgcttatc tgacagccct
    27661 caaggaagtt atccagtacg ctggcatttc tgacgttaag atggaagaag gttctatgcg
    27721 tgtggatgcc aacatctccc ttcgccctta tggtcaagaa aaattcggta ccaagactga
    27781 attgaagaac ctcaactcct tctcaaacgt tcgtaaaggt cttgaatacg aagtccaacg
    27841 ccaggctgaa attcttcgct caggtggtca aatccgccaa gaaacacgcc gttacgatga
    27901 agctaacaaa acaaccatcc tcatgcgtgt caaggaaggg gctgctgact accgctactt
    27961 cccagaacca gacctacccc tctttgaaat ttctgacgag tggattgagg aaatgcggac
    28021 tgagttgcca gagtttccaa aagaacgtcg tgcgcgttat gtatctgacc ttggtttatc
    28081 agactacgat gctagtcagt tgactgctaa taaagtcact tctgacttct ttgaaaaagc
    28141 tgttgcccta ggtggtgatg ccaaacaagt ctctaactgg ctccaagggg aagtcgctca
    28201 gttcttgaat gctgaaggta aaacactgga acaaatcgaa ttgacaccag aaaacttggt
    28261 tgaaatgatt accatcatcg aagacggtac tatttcatct aagattgcca agaaagtctt
    28321 tgtccatcta gctaaaaatg gcggtggcgc gcgtgaatac gtggaaaaag caggtatggt
    28381 tcaaatttca gatccagcta tcttgatccc aatcatccac caagtctttg ccgataacga
    28441 agctgctgtt gccgacttca agtcaggcaa acgtaacgcc gacaaggcct ttacaggatt
    28501 ccttatgaag gcaaccaaag gccaagccaa cccacaagtt gcccttaaac tacttgcaca
    28561 ggaattggcg aagttgaaag aaaactagac agaacaaaac cagccctaag gttggttttt
    28621 tcttctctac caactcccaa taactatttt ggctttattt ccagagtatt ttatggtaaa
    28681 atgaagagta ataatattta ttaaagaggt aaaaacatga ttgaagcaag taaattaaaa
    28741 gctggtatga cctttgaaac agctgacggc aaattgattc gcgttttgga agctagtcac
    28801 cacaagccag gtaaaggaaa cacgatcatg cgtatgaaat tgcgtgatgt ccgtactggt
    28861 tctacatttg acacaagcta ccgtccagag gaaaaatttg aacaagctat tatcgagact
    28921 gtcccagctc aatacttgta caaaatggat gacacagcat acttcatgaa tacagaaact
    28981 tacgaccagt acgaaatccc tgtagtcaat gttgaaaacg aattgcttta tatccttgaa
    29041 aactctgatg tgaaaatcca attctacgga actgaagtga tcggtgtcac cgttcctact
    29101 actgttgagt tgacagttgc tgaaactcaa ccatctatca aaggtgctac tgttacaggt
    29161 tctggcaaac cagcaacgat ggaaactgga cttgtcgtaa acgttccaga cttcatcgaa
    29221 gcaggacaaa aactcgttat caacactgca gaaggaactt acgtttctcg tgcctaatct
    29281 ctagaaagag gtcattctat gggaattgaa gaacaacttg gcgaaatcgt tatcgcccca
    29341 cgtgtacttg aaaaaatcat tgctatcgct actgcaaagg tagagggtgt tcactctttt
    29401 tcaaacagat cagtgtctga taccctttca aaactttcac tcggccgtgg cgtttatctt
    29461 aaaaacgtgg acgaagaact cacagcagat atctatctct accttgagta cggagtaaaa
    29521 gttcctaagg tagcggttgc tatccagaaa gctgtcaaag atgccgtccg taatatggct
    29581 gatgtagaac tcgctgctat caatattcac gttgcaggta tcgtcccaga taaaacacca
    29641 aaaccagaat tgaaagatct atttgacgag gacttcctca atgactagtc cactattaga
    29701 atctagacgc caactccgta aatgcgcttt tcaagctctc atgagccttg agttcggtac
    29761 gaatgtcgaa actgcttgtc gtttcgccta tactcatgat cgtgaagata cggatgtaca
    29821 acttccagcc tttttgatag acctcgtttc tggtgttcaa gctaaaaagg aagaactaga
    29881 taagcaaatc actcagcatt taaaagtagg ttggaccatt gaacgcttaa cgctcgtgga
    29941 gagaaacctc cttcgcttgg gagtttttga aatcacttca tttgacactc ctcagctggt
    30001 tgctgttaat gaagctatcg agcttgcaaa ggacttctcc gatcaaaaat ctgcccgttt
    30061 tatcaatgga ctgctcagcc agtttgtaac agaagaacaa taaaaagaaa aagtgtttga
    30121 tagatatcaa acactttttc tttgcctccc actatctaaa aaaatgataa tagatataat
    30181 tgtaaacaaa aatccagata ggttttgcat gattgagaaa gttaaaaaaa ctatggcaga
    30241 gaatcgttaa tctcagattg tcggtagaac gataaacaag ggcaaaaaag aaaccaatca
    30301 gactataata taataaacta attggatctc tgtgagatag tatcaaatgg ctaatcccaa
    30361 agataaggcc tgataagatg acatctaaat agtactttga cttaggaaag aaggtattca
    30421 tcaaataccc tctatcaaga gtctcctcaa aaacaggacc gatgattaca agcaggacaa
    30481 aagataagat agtcgataaa aaggttggtt gtccatttga aagaaccacg gtaaaatact
    30541 catcatgaat attcctatgg ttaatcaaat gagcatagcg tgcctaaaaa ttaccgagaa
    30601 tctgataaac cacatacgtt gcaaataagt agaagacaaa tgaccagttc cagctctttt
    30661 tttcaaagat aaagagcatc tttttctttt ttaacctcca aatcaataga aggaaacttc
    30721 ccactaatac cattgttaaa ataagagaat agacatcagc tcctaaccct aaaatgatcg
    30781 tcacatacaa tccaattgtt tgtggtaaat aggtagatag taaaataata agcaaaaata
    30841 ttccaaattg tcttagtttt tttgtgtttc tcatcgtact tttttgaaag attaccctgc
    30901 tcggaagccg tacttccaag catctatata agaattaagt gccccttgcc tcatataggg
    30961 agcaaattct ctataatata accatctact atatccatct tcccaaacag caagaccacc
    31021 tgaagtttgc tccaagtcct cagttgaaag aactgtaaat gtatttgtac ctgtcattgc
    31081 aagtaccttc ttaaaataga ttgttgtagg ctcacattta tagtatattt ctttttttgt
    31141 ctattttata gtctatctcc tcaactgtca atttttcaac ctgaattgca tttttccata
    31201 aaaaatgaga cctttctagt ctcatttagt cattcttagt attttctaaa tcgttgatag
    31261 cgttcttcca gcaactcttc tagcggtttt tgtgaaagtc tagccagctc cgtttggagt
    31321 tcttttttga cactcttaat cagttcttta ctagaaagtc ctacttcaga aatcacctta
    31381 tccaccacgt ccatttctaa cagttcatgc gaagtgattt tcatcagttc tgctgcttcc
    31441 atggcgcgag taccgtcctt ccataaaatg gaagcaaagc cttctggact gagaatggca
    31501 tagatagaat tttccagcat ccagacacgg tccgcgacag ctagagccag agccccgcct
    31561 gaaccacctt caccgataat aatggcgata ataggaactt tcaggtcact catttccatg
    31621 agattgcgag cgatagcttc cccttgacca cgttcttctg ctccgacacc aggataagca
    31681 cctgctgtat taataaaggt cacaactgga cggccaaatt tctcagcctg tttcatcaac
    31741 cgcagtgcct ttcggtagcc ttctggatgt ggttggccaa aattccgttt gaggttgtct
    31801 tgcaaactct tgcctttttg gataccaaca actgttacag cttggtctcc aagccaacca
    31861 ataccaccaa caactgcacc atcatcacga aaagaacggt caccatgtaa ttggataaat
    31921 tcatcaaaaa tgcctgtcgc aaagtccaag gttgtcaagc gactctgctc acgcgcttct
    31981 ctgactattt ttgcaatatt catctaggac tccctccatg caatctgact aggctagcaa
    32041 tcgtatctgg taagtctctt cttttgacaa tagcatccac aaagccatgt tctaatagga
    32101 attctgcctt ttggaaatcc tcaggcaagc tttcacgaac cgtattttca atcacacgac
    32161 gcccagcaaa accaaccaag ctctgtggtt cagccagaat gatatcgcct tccatagcga
    32221 aagaagctgt cacaccacca gtcgttggat ctgtcaaaat ggtcaggtaa aagagaccag
    32281 catttgaatg gcgtttaacc gccgcagaga tcttagccat ctgcatgaga ctcatgattc
    32341 cttcctgcat acgggctcca ccagaggctg tgaataggac aactggcaat ttttcgacag
    32401 tcgcatactc aaacaaacga gtgatttttt cacctacaac cgtacccata gaagccatga
    32461 taaagttaga atccataatc ccaagagcca cagtctgacc tttaataaga gcagttcctg
    32521 tcacaacggc ttcatgcaga cctgtttttt cacgcataga tgccagtttc ttttggtaac
    32581 cagggaaatg caagggatcc ttgctttcaa tccctgtaaa caattctttg aaggttccca
    32641 tatcaatcgt caaagccaag cgttcttggg cagaaatacg aaaggtatag ctacagtgcg
    32701 gacagatacg ttcacttccc agatccttct gatagatggt atgcttacag cctggacact
    32761 gggaaaataa ttcatctgga acctctggct tagcttgagg tttttcccta accgaacgat
    32821 tgggattgat tcgaatatac ttatcttttt tactaaatag agccattgat tccccttttc
    32881 ggtttaaact cttaaagtca ttttattctt tttcttgata tttaggtaag aaggtttcca
    32941 tcaagaagga agtatcataa tccccagcaa tgacattgcg atctgaaatg aggtcaagct
    33001 ggaaatctgc attggtctgc actccttcaa tctctaattc atagagggca cgttgcattt
    33061 tcatcaaggc gtcaaaacga ttttcgccgt gtactatgat tttggcaatc atactatcat
    33121 aataaggcgg aatggtataa cctggataaa ctgctgaatc cacgcgcaag ccaactccac
    33181 cacttggcag atagagatta gtaatcttac ctggacttgg agcaaagtta aaggctgggt
    33241 tttctgcatt gatacgacac tcgatggcat gaccacgtag gacaatatct tcttgcttaa
    33301 cagacaaagg ctgacctgcc gcaatgcaaa tctgttcctt aacgatatca acacctgaaa
    33361 caaactctgt tactggatgt tctacctgaa cacgagtatt catctccatg aaatagaaat
    33421 tgctacttgc ttcatcaaga agaaattcaa tggttcctgc attctcatag ccaacaaact
    33481 ctgccgctcg aacagcagca gcacctattt catgacgcag cgtttttccg attgcaatcg
    33541 agggactttc ttccaaaacc ttttggttat tcctttgaag agaacaatcc cgttcaccca
    33601 agtgaatcac atgtccatgc tcatcaccta ggatttgaac ctcaatgtgc cgagctggat
    33661 agataacccg ttctatgtac atggcaccat tgccataatt ggccttggcc tcactagagg
    33721 cagtttcaaa ggcagaaacg aggtcatctg gtttttcaac cttacgaatc cctttaccac
    33781 ctccacctgc tgaagccttg agcataacag gatagccaat tttttcagca acaatcaaag
    33841 cttcttcaga gttatgcact tctccatctg aacctggtat aacaggcaca cctgctttaa
    33901 tcatctgagc acgcgcattg atcttatccc ccatcatatc cataacatga ccagatggac
    33961 cgataaactt gatacctact tcttcacaca tggtcgcaaa tttggaattt tcactgagaa
    34021 atccaaaacc agggtgaata gcttctgcct cagtcaagac tgcagctgat agaactgcat
    34081 taatattgag ataagactct gttgccttgc caggaccaat acaaactgct tcatctgcca
    34141 aaagcgtatg aagagcttcc ttatcagcag ttgaataaac cgctaccgtc gcaatcccca
    34201 attcacgtgc cgcacggata atacgaaccg caatttcacc acgattggca attaaaattt
    34261 ttcgaaacat ggagaacctc cttagttccc aattgcaaaa gtaaggatac cactggctgc
    34321 aagcttgcca tccacttcag cctttgcttc aaccacagct atggtgccac gacgttttac
    34381 aaaagtcgct gtcataacca attggtcgcc tggtacaact tgcttcttga acttaacctt
    34441 gtccatacca gcgtaaaaga ccagttttcc tttattttca ggttttgata actccaacac
    34501 accagcagtt tgcgccaagg cttccataat cagaacacct ggcataactg ggtattgagg
    34561 aaagtggccg ttaaagaaag gttcgttaat ggtcacattt ttgatagcaa caatggtatc
    34621 ctcgctcact tccaagacac ggtccactag aagcatagga taacggtggg gaagagcttc
    34681 tttgattcct tgaatatcga tcatttgata cgtaccaatc ctttaccaaa ctcaaccatt
    34741 tcttcgttag agacgagaat ttccgttacc acaccatcct taggagctgg gatttcattc
    34801 atgactttca tggcttcgat aattaccaat gtttgacctt ttttgacact atcaccaact
    34861 gtaacgaagg caggtttatc tggtccagca gccaagtaaa ccactccaac aagtggactc
    34921 tctacaagat ttccctcact agccacactt gcttcagctg gagctggaac ttcttctgct
    34981 acagtctctg ctggagcaga tgtaggagct actggactcg gtgttgctag aacgggtgct
    35041 ggagcgactt gagttgcaac ttcaggcaca ggtcttgctt cattcttgct aaactgcaac
    35101 tcatccgtcc catttttata agaaaattct ctcaaacttg actggtcaaa ttgagtcatc
    35161 aagtctttaa tatcgtttaa attcatactt atctattctc ccaacgtttg aaagcaagaa
    35221 ctgcattgtg gcctccaaaa ccaaaagtat ttgaaatagc gtatggaatt tctttctcca
    35281 agccttgtcc ataaacgaca ttagcttcga tataatctga tacttcactt gtcccagctg
    35341 tcattggtac aaagttatga cgcatagctt cgatggtgac gatagcttct actgcacccg
    35401 cagcccccag taaatgtcct gtaaaagact tggttgatga tacaggtact tccttaccaa
    35461 gaacagctac gatagctcca ctttctcctt tttcattggc aggagttgac gttccgtgag
    35521 cattgacata ggctacttgc tctggagaaa tctcagcttc ttccaaggct agtttgatgg
    35581 ccttgatagc tccctgacct tctggatgtg gagaagtcat gtggtaggca tcacaagtat
    35641 ttccgtaacc aaccacttca gccaggatag tagctccacg tttttcagcg tgttcaaggc
    35701 tttctagaac caacatccct gaaccttcac ccataacaaa cccattgcga tccttatcaa
    35761 atgggatcga agcacgagtt ggatcctctg tagtagagag agctgttaag gcttggaaac
    35821 cagcgatggc aaaaggtgtg atagaagctt ctgttcctcc caccaacatc acatcttgga
    35881 aaccaaactt aatggagcgg aaggcatccc caatcgcatc atttgatgaa gagcaggcag
    35941 tattgataga tttacaaaca ccgtttgcac caaaacgcat ggctacattc ccagaagcca
    36001 tatttggtaa agcttttgga agagtcattg gtttgacacg tttgggtcct ttttcatgaa
    36061 ggcgaagtac ctgatcttca atttccttga ttccaccaat accagatgca acgataacac
    36121 caaaacgatc cctattaaga gcctctacat caagattggc atgatttaca gcctcttggg
    36181 ctgcatacaa ggcatataaa gaatagttat caaaacggtt ggtatctttt tttacaaagt
    36241 atttatcgaa cggaaaatct tggatttctg ccgcattatg cacatcaaag tcactatgat
    36301 caaattttgt aatgccacca atgccgattt tcccagttgc taaactattc caaaattctt
    36361 ctggtgtatt tccgattgga gatgttactc cataacctgt taccactact cgatttagtt
    36421 tcattctttt cacctctagc tttcgctaca tacttaagcc accatcaatg gcaatcactt
    36481 gaccagttag ataatcttgg cctgctaaaa atactgtcaa atctgcaacc tgctctgcct
    36541 gcccaaattc tttcatcgga atctgagcta gtgtagcttc cttaatctta tctgataaga
    36601 tagctgtcat atcagactca atcattcctg gagcaatcac attgactcgt atattccgac
    36661 tagcgacctc gcgtgccaca gacttggtaa agccaatcaa gccagcctta gaagcagcat
    36721 agttagcttg accaatattc cccatcaaac caacaacact agacatatta atgatagcac
    36781 cttctctggc tttcatcatc ggtttcaaga ctgattgtgt catattaaag gcaccagtca
    36841 gattgacctt gagcactttt tcaaaatctg cttctgtcat cttgagcata agagtatctt
    36901 gggtaatccc tgcattgttg accaaaacat ctactgaacc cagttctgca atagcttgat
    36961 caatcatacg cttagcgtct gcaaaatctg atacatctcc tgaaatggga accaccttga
    37021 taccatagtt tgaaaactca gcgagcaatt cttctgagat tgccccacga ctgtttaaga
    37081 caatgttggc tcctgcttga gcaaacttgt gggcgatggc aagaccaatt ccacgactcg
    37141 aacctgtaat aaagatattt ttatgttcta gtttcatttt tttcctttca aaacttctac
    37201 ttattttagt ctatttttct aaaagtgcta ctaaactcgc ttgatcttcc acatgagcta
    37261 agtgagcagt ttgatcaatt tttttaacaa aacctgacaa gactttcccc ggtccaatct
    37321 cgataaagtt gcttatgcct gcttcttgca tgaccccaat actttcatag aaacgaacgg
    37381 gttccttgac ctgacgcgtc aagagctgag caatgtcctc tttttgcatc acagcagctt
    37441 ctgtattgcc gactagggga caagtaaaat ctgaaaaact tacctgagct agagtttcag
    37501 ctagtttctg gctagctggc tcaaggagag cggtgtgaaa gggacctgac accttaagag
    37561 gaatcaagcg tttggcacct gcttcttgca aaagttcaac cgctcgatca actgcaacca
    37621 cttctccagc aatgacgatt tgtgcaggtg tgttatagtt ggctggagta accactccaa
    37681 gttcagaagc tttttgacag gcttcttcaa tgacctctac tggcgtattg agaactgcta
    37741 ccatcttgcc agagtcagca ggagccgctt cttccatata ggctccacgc ttagctacca
    37801 aggcaaccgc atcttcaaaa tccaaggcgc cgcttgccac caaggcagag tattctccaa
    37861 gagacaaacc agcaaccata tcaggctgat agcccttttc ttgcaataaa cggtagatag
    37921 caaccgaagt cgctagaatg gctggttgcg tatagcgggt ctgattgagt ttgtcttctt
    37981 ccgtatcgat gagataacgc aaatcataac ctagcacctg actcgctcga tcaatcgttt
    38041 ctttaacaat cggatactga tcatagaaat cccgtcccat ccctagatac tgggcacctt
    38101 gaccagcaaa taaaaaggct gttttagtca tttcttacaa ctcctgccca gcgagaggct
    38161 tcttcttgaa ttttcttagc ggctccgtaa tacaaatctt ttaggatttc ttcagctgtt
    38221 tcttctttag aaacaagccc tgcgatttga cctgccatga cagagccacc atccacatca
    38281 ccgtgaacaa ctgctttggc tagggcacct gctcccattt gttcaaagat ttctaaatca
    38341 ggatcttcct gcttaaaggc atctttttca gccagttcaa aatctctagt caactgattt
    38401 ttaatagcac gaacagcatg accaaagtgc tgagctgaaa tcgtagtatc aatatccctt
    38461 gcttttaaaa ttttctcctt gtagtttgga tgggcattcg actcttttgc aactacaaac
    38521 cgtgtcccca cctgtacagc ctctgcacct agcataaagc cagccgcagc accttcacca
    38581 tccgcaattc ctcctgcagc aataacagga atagatatag ctgtggctac ctgtcgcacc
    38641 aaggtcatgg ttgttaattt accgatatgc cccccagctt ccattccttc tgcaataaca
    38701 gcgtctgcac cgattttttc catgcgttta gctaaagcga cactaggaac aacaggaata
    38761 acgattatcc cagcttcatg gaaacgttcc atatacttgc ttggatttcc tgctcctgtt
    38821 gtgacaactt taacaccttc ttcaataacg agatccacga tatcttccac aaagggagat
    38881 aagagcatga tgttgacccc aaagggttta tcagtcaatg atttgatttt atcaatattg
    38941 gccttgacaa cttctttcgg ggcatttccc ccaccgataa ttcctaatcc tccagccttg
    39001 gaaacagccc ctgccaaatc accatcagca acccaggcca tccctccttg gaaaatagga
    39061 tagtcaatct tcaataattc tgtaatacgc gttttcatag tgcctccaac cttccttgct
    39121 tacgtaatag ttcgatttca ccataatttg acagtcaaac tattacctaa acaagaggga
    39181 gtgggtttct ccctactcct tctactaata ttctgcttat tttgcttgct cttcaacgta
    39241 agcaaccaag tcaccaactg ttttcaagtc attttctgct tcgatttgga tatcaaaagc
    39301 atcttcgatt tctgagatta cttggaacaa gtccaatgaa tctgcgtcca aatcatcaaa
    39361 agttgattca agtgttactt ctgatgcgtc ttttccaagt tcttcaacga taatttcttg
    39421 tactttttca aatactgcca tgataggact cctttaaaat aaatagtttt tttataacaa
    39481 tgtgttcacc acatgattac ctaaattgta agaatgagcg tgccccaggt caagcctcca
    39541 ccgaagcctg atagaagaac agtctggcta ccatctaaag ggatgagacc ttgttctaca
    39601 cactctgaaa gtaaaatcgg gatactggct gcactggtat tgccatattc catcatattg
    39661 gctggaagtt tggctcggtc aacaccaatt tttctagcca tcttatccaa aatacggtca
    39721 ttggcttgat gaagtagcag ataatccaag tctgtcacct ctataggaga ttcatcaata
    39781 gtctgcttga tagacttggc tacatctcga atggcaaaat caaagactgt gcgtccatcc
    39841 atcttcaaaa acgaatctgc actttcttga tctgaaaatg gagaatgcaa acctgaatgc
    39901 ccataagtta aacactcgct gcgacttcca tcgctattga gactctcagc taagaaatgc
    39961 tcttgctcgc tagcttctaa caagacacca ccagcaccat ctccaaacaa cacagctgtt
    40021 gatcgatccg accaatcgac tgccttagag agggtttcac taccaatcac caagcctttt
    40081 tgaaagcgac cagaagcgat aaacttttca gcagttgaaa gagcaaatac aaatccactg
    40141 caagccgcgg ttaagtcaaa agcaaaggct ttattagcgc caatattagc ttgaacacga
    40201 gcagctgtag agggcatcat cgaatctgga gtaatggtag ctaggatgat aaaatccagt
    40261 tcttttcctg ttattccagc ttttgccatc agtttcttag caacctctgt agccaaatca
    40321 ctggtagatt ctgttcttga aatatgcctt tgtcgtattc ccgttcgact tgaaatccac
    40381 tcatcattgg tatccataat ctgagccaag tcgtgatttg taaccacttg ctctggcaca
    40441 taatgagcaa cctgacttat ttttgcaaaa gccattattt caaatcctcc aaaaattggt
    40501 aaagattagt caaaccttta cccatgacag caatttcttc ctcgctcatg ccatcaataa
    40561 ttttttctac catggccttg tggaagcgtt tatgcagcct atgaatcaag cgacccttct
    40621 ttgtcaaatg cagatgcacc acacgacgat cctgttctga ccgaactcgc tcaatgtagc
    40681 ccttacgctc taaattgttc aaacttgtcg taacagttcc aagagttacc atcaactctt
    40741 ttgacacttg acttggagtc acgtctggag ccttaccgat gacatcaatc gtatgcattt
    40801 ctttgatgga gatatcctta aaacgactac ctctcaagtt cacttcctca attacaagga
    40861 cattgttaaa tatagatgtt aaatattcat tgattcgttg gtagtccatt tttcatatcc
    40921 ctccttcttc aaaaaacttt tacaatcaaa acatttgaca gaaagaatta tatcaaaatt
    40981 caaagaatga tgcaagtatt ttttattttc ctgtaaattt aggtcttctt ctctccgaat
    41041 gagctcgcac tccttctttg aaatcctctg tttgagctaa ggatttctgt aggttcagtt
    41101 ctaaagtagc gtaaccctgc cagtctttaa attggctctc ccaaaccaac ttcttaatgg
    41161 cagcatagga attacttgaa gcacgtctta attttttaag aagctgttct ctcgtctttt
    41221 caagtttttc agcttcagaa acgcgataaa ccaaccccca ttctagggct ttttctgccg
    41281 ttaaagcctc tcctgtcata gctaattgag cagcacgcgt cacaccgata ctgcggctca
    41341 agagatgaat tccccctgca tctggagcca aaccaacacc aacaaaggct tggataaact
    41401 tagccttatc cgtcgccaaa cagaaatctg ccgcaacagc catattcgct gcggcacctg
    41461 caacagcacc gtcaacttcc attaaaacag gtttggctat ttgcttgatt ttataagaaa
    41521 tcgtattgac caactctgcg atttttgtca atgatggaat atcatcctca tccactgccc
    41581 gcttcatctc taccaaatct cccccaactg agaagacctt tccattggca ttgattaaga
    41641 taaaatgcac agctggattt tcttctgcca aagtcagagc ttctaaaatc tcctcacaca
    41701 tgggaatatg aaaaccattt gcgacctcag gacggttcaa ggtaaggatt gccaagtcct
    41761 cttcaagctg ataaataatg tgttccatca gggctccttt ttattttata agcagtttat
    41821 actcttcgaa aatctcttca aaccgcgtca gcttccatct gcaacctcaa agcagtgctt
    41881 tgagctgact tcggctagct tcctagtttg ctctttgatt ttcattgagt gttaaattat
    41941 ttcactgtca aagtatatct tttttaggag cagaaagcaa gaaaaaatcg actgaaagtg
    42001 tctcagccga taagaaaggc tcgctttagg ctagaaagca tcttattttc ttcattgaaa
    42061 aaagcctttc tttctgctat aatcgtataa aatacttact ttaggagttc ttatgaaagt
    42121 tgttaaattt ggaggtagtt ctcttgcctc tgctagtcaa ttagaaaaag ttttaaacat
    42181 cgtcaaaagc gattcagagc gtcgttttgt agtcgtttct gcgcctggta aacgcaatgc
    42241 tgaagatact aaggttacgg atgccctgat taaatactac cgcgactatg ttgcgggtaa
    42301 cgatattagc aagagccaaa gctggattat cgaccgctat gctgctatgg ttagtgaatt
    42361 gggactaaaa ccagctgtgc tagaaaaaat ttctaaaagt attcacgcct tggccactct
    42421 tcctattgaa gaaaatgaat ttctctacga tactttccta gcagccggtg aaaataacaa
    42481 tgccaaattg attgctgcct actttaacca aaatggtatc gatgcacgct atatgcaccc
    42541 tagagaagct gggattgtgg tcacaagtga acctggtcac gctcgcatca ttccatcaag
    42601 ttatgacaag attgaagaat tgacaaacac caatgaagtc cttgtcattc ctggtttctt
    42661 tggtgtcact aaggaaaatc aaatctgtac tttctcacgt ggaggttctg atattacagg
    42721 ttctatcatt gctgctggtg tcaaagctga cctctatgaa aactttacgg acgttgatgg
    42781 tatctttgca gcccaccctg gtattatcca ccaaccacac tcgattcctg agttgaccta
    42841 ccgtgaaatg cgcgagttgg cctatgcagg cttctcagtc cttcatgacg aggctcttct
    42901 tcctgcctac cgtggaaaaa ttcctctggt tatcaagaat accaacaacc ctgaccatcc
    42961 aggtactcgt atcgttctaa aacacagtaa tgatgaattt ccagttgtgg gaattgctgg
    43021 tgactcaggc tttgtcagca ttaacatgtc gaaatacctc atgaaccgtg aggttggatt
    43081 tggccgcaag gttctgcaaa tcctggaaga acttaacatc ggttgggaac atatgccaac
    43141 aggtatcgac gatctttcta tcattctccg ttctcgccaa ctaactccca tcaaggaaga
    43201 agaaatcctg cgtcagttgg ttcaaaaggc taaagtagat catgcagaaa tcgaacacga
    43261 cctttctatc attatgattg ttggtgaaaa aatgaagagc cacatcggag tgactgctac
    43321 tgcgacacgc gctctatctg aaaacaaaat caacatccag atgatgtctc aaggttctag
    43381 tgaagtttct attatgtttg ttgtcaataa agaccaagag aaagcagcaa ttaaagccct
    43441 ctacaatgcc ttttttggag aaagtaagga agactaagca tggcccaatc acttaacaaa
    43501 acagtactcc tcagtacgac aggcacttcc tacctctcta tcgctgggaa agttgggaaa
    43561 ttccttgtcg gagatcaggc tttggaattt tacccagatg tcaatgtcga acaatttatc
    43621 cagattcctt ggagccatat caatcagatt ggagccaatg tcactggacg caaaatcagc
    43681 cgccacttcg aagtctttac agacaaagga aaattcctct ttgcttcaaa agactcaggt
    43741 gccattctca aaattgcacg caaaaaacta ggcaatgaca aggtcgtcaa acttccgacc
    43801 ctgattcaga caattagcca aaaatttaaa aatctatttg caaaaaagta gaaactttag
    43861 tataatcata gcaacggata agtaggttat cttcttcttt cagaaagtct gcgggtactg
    43921 cgagcagata ggagggatag gtgaaattct accgttaata acaattacat acacaatcaa
    43981 gtgcacacct gtgaagttgg atggaaccgt ggccctgcca ctccaacgtt ttgtcaggcg
    44041 tgcttttttc ataaaggagt tcttatgtta gatatcaaac gtattcgtac agattttgaa
    44101 gctgtcgcag aaaaattagc tacacgtggt gtagatgctg ctgtcttgaa tgaaatgaaa
    44161 gaaatcgatg ctaaacgtcg taacatcttg gtcaaggttg aaactctcaa agcagaacgt
    44221 aacacagttt ctgctgagat tgcccaagct aagcgcaaca aggaaaatac agatgacaag
    44281 attgctgcca tgcaaaatct atctgctgag gttaaagcct tggatgctga attggcagaa
    44341 atcgatgcta aattgacaga atttacaacg actcttccaa atatcccagc tgacagcgtt
    44401 cctgttggga ctgacgaaga cgacaatgtg gaagttcgcc gttggggtac tccacgcgag
    44461 tttgacttcg aacctaaagc tcactgggat ctcggtgaag accttggtat ccttgactgg
    44521 gaacgcggtg gtaaggtaac aggcgctcgc ttcctcttct ataaaggcct cggtgctcgt
    44581 ttggaacgtg ctatctacaa ctttatgttg gatgaacatg gaaaagaagg ctatactgaa
    44641 gtcatcacac cttacatagt caaccatgat tctatgtttg gtactggtca gtatccaaaa
    44701 tttaaggaag atacttttga actcagcgat accaactttg tcttgattcc aactgctgaa
    44761 gttcctctga caaactacta ccgtgatgaa atcttagacg gcaaagatct tccaatctac
    44821 ttcactgcta tgagtccgtc attccgttct gaggctggtt ctgccggtcg tgatacgcgt
    44881 ggcttgatcc gtttgcacca attccacaag gttgaaatgg tcaaatttgc caaaccagaa
    44941 gaatcttacg aagaattgga aaaaatgaca gccaacgctg aaaacattct tcaaaaactc
    45001 aaccttccat accgtgtcgt tgctctctct actggagata tgggcttctc agctacgaag
    45061 acttacgact tggaagtgtg gattccagca caaaacaatt accgtgaaat ctcaagctgt
    45121 tcaaacacag aagatttcca agcccgtcgt gcccaaatcc gttaccgtga tgaagcagat
    45181 ggcaaggtga aactccttca taccttgaac ggttctggac ttgcagttgg acgtacagtg
    45241 gctgcaattc ttgaaaatta ccaaaatgaa gatggttctg tgaccatccc agaagcactt
    45301 cgtccataca tgggtggagc tgaagtcatc aaaccataaa aaataaggtt tagctatttc
    45361 tagctagacc tttttcgtaa ccaaatcaga taagcaccta gtacaaagaa taaaatagtt
    45421 aggcatataa tggtttcagc caataccagg taatccagaa atggaagttt caaaattccc
    45481 tgagccatct tgagcgaggt cgctgtgata atggttggga aggtgagggc tgagaaggct
    45541 ggttgaaaac cttgttttaa aatgttgggc agacgagtta aaacaaagaa aaagaaggat
    45601 tgagaagcca aaatcatgac aatcaagacc caagtcggca ggctggttcc tcctactcga
    45661 actagagaag ccaagagtag agagaaagga gcacagtaga ttccttcttg tccaagcaag
    45721 gctagtggga gtggatgttt ctttaaatcg ctataaataa ggggatagag atagaaggtc
    45781 aagagaaaac caaaactcaa ggtcgcatag gcaatttcga taatacctac cagaggatag
    45841 gtcaaggcag ccactgctat ccccacatag agaaccgtcc aacttggagt ggcatgaacc
    45901 ctccgccctg gacaagcaaa cttgatggta aaaccagcaa tcaaggtcaa atccaagaga
    45961 aatgaaaacc accaaatccc ttgtgctacc aaaggaagat aagagaatac gcgaaagaca
    46021 taggtcgata aaatcatccc agccatagga aaggttgcca ttcctgacaa aagagggggc
    46081 ttggtcaatt cttgcttggt ttctttccaa ttaaagagat gcagaattag aaagtaaatc
    46141 cataaaacca aaccagtcag actaaaaaga tgggatagaa ccggcaacgt atctaaaata
    46201 agatttccag ctcctgccaa acctagcaaa caacctgaaa atactaaggg gagttttttc
    46261 atcctaacct ccaataatca tgttagtttc agtataacat aaaagcgctt aaatgaggat
    46321 ttaaaaaaac gaagtccgct tatttcagac ttcattttac tcagatatga attaggcata
    46381 aggttgcaat tctggattaa ttggtgtatt agctaagttg ttggcatagt tacagaggat
    46441 tgctaggctg acaccaaaaa ccacatccaa ggcattttgt tgagtgtagc cagcttctaa
    46501 aaactcagac aaggcttcat ctcctacacg acccttggta ttgataactg ccaaggtaaa
    46561 cttagctagg gtatccaatt taggatctgt ttcaattgga gtacgattgc gaagagcttg
    46621 aatcaagtca tcattcatct ggatttgttt tatggaaaag gctgtgtgac ctgcgacaca
    46681 gaaggcacaa ccattggtca cggctgccgt gatttgcacc acttcacgct caacgggtgt
    46741 caggctgttg cgacggtgga tagatgagac aatttggtag gcttctaaaa cagtcggggc
    46801 attggccaag agaccgatta ggttgggaat atagccattg ttgtcttttt ctactgtttc
    46861 aagaatttct ttcacttctg ctggtgctga ctctactgta tggatagtaa atgttgtcat
    46921 aagatacctc ttttcttatt attgacacta atattattgg aaaatcttat aaaatcctga
    46981 ttcctaagtt tatctaagat aaagctttat tctctcataa gattttcgtt gttatattag
    47041 tttatcacac ttccaatcac ttgcataata tatattatat atcaggctga taaaaattat
    47101 ttataggcaa aaaaatcaca cgagctgtgt gattccatta tttgtcaaaa tactttttag
    47161 tttcagcaat aacgactggc gacaagacca agagggcaat caagtttggc agagccatca
    47221 aggcgttaac gatatctgcg ataatccaga ccatatccaa ctcgataaat cctcctaaca
    47281 agaccatgag cacaaaaacc acacggtaga gccagataaa gcgagcccca aagaggaact
    47341 caaaacagcg ttctccgtaa tagttccaac ctagaatcgt tgtaaaggca aaaagtacaa
    47401 ggaagatggt caagagggca ggcccaaagt gtgaaaagac tgttgagaaa gctgactgag
    47461 tcaaggcaac cccattcaag tcaccactcc aaactccagt taccaagatg gtcaaaccag
    47521 ttagagtaca aatgatgagg gtatcaataa aggttcctgt catggaaatc aaaccttgct
    47581 ctactggttc atttgtcttg gcagctgcag ctgcaatagg agcagaaccc agaccagatt
    47641 cgtttgagaa cacaccacgc gccacaccat tttgaatagc catccgaacg ctagcaccag
    47701 caaatccacc taccgcagca aggggactaa aagctgaggt aaagactaaa gcgattgtgc
    47761 cagggatttt tccgatatta aagaaaataa ctgtaagagt tcctaagata taaatgaggg
    47821 ccataaaagg aacaacagta gttgaaacct tagaaataga cttgagtcca ccaaagactg
    47881 caatcgctac aaagacagac aagacgagag ctgtgatggc tggcgaaatc gtcgttgtat
    47941 tttggataga ttctgtaatc gagttgactt gggtgaaggt tccgattccc aagagagcaa
    48001 ccaatactcc tgctactgca aacaaaacag caagtggtcg ccacttttct cccatcccta
    48061 gaaggatata gtgcatggga cctcccgcta ctgcaccatg gtcgtccttg gtgcggtatt
    48121 tgatggccaa gagtccttcc gcatacttgg tagccattcc aaagaaagcc gccatccaca
    48181 tccaaaatag agctcctggt ccaccaacct tgatagccgt cgcaactcct atgatatttc
    48241 ctgttccaac agttgatgcc aaggctgtac acagagctgc aaaactggat acatcaccat
    48301 gtcccttatc ctggataaaa ataagctgaa aggccttggg cagacgcaaa acctgcaaga
    48361 gtcctagccg catggttagg taaatccctg ttccgaccaa taaaatcaag aggggcggtc
    48421 cccaagcaaa agcatcgatt gatttaagca attctaacat ttccttctcc tatcgtttca
    48481 accccaaaag aaagagcaca tgcaagatac atgtactctg gaatgcttag ataaatgcta
    48541 aaaagcggtc tatcctagct ctgtcctttt acctgagagt ttgagcagtt gcctgccttg
    48601 ccccttcggt gcctttacgg tctctccaga gttccgtcca tttacagtca tggaaaatca
    48661 aacgattccc cacttctatt aaacttcatt cggtgttggt atttaattga ttctaatttt
    48721 acaaaaaatg ttggcttttg tcaatgtgtt tattagtaaa aattagttca acagttttta
    48781 ctttataaag tccagaatac tgctatcctt taaaagtgac aatagtcgca ccactgcctc
    48841 cagcattttg tggggcatag ccgaaactct tgacatgttt gtttctttgc aagtatttgg
    48901 taactccttc acggatgact cctgttccga taccatggat gatatcaact tgagccatat
    48961 tgttaagcaa ggcttggtcg atgaaggtat ctagctcatt catggcttct tcatagcgct
    49021 tgcctcgaag atccagtcta gcttgaggtc ctcgcccaga agttcgtttc acaacattga
    49081 cctgtttctt cttgactggt ttttcttgct gggcttgaac aagatcaaac tctttctctt
    49141 ccaaggtcat cttaatcaag ccaacttggg cttcccagcg accgtccttg agttgactgg
    49201 tcaaggtacc acgctgacca taactgagaa ccacgatatc atctcccacc tttggagctc
    49261 gttttttctt ggccttttga aggaccttat ttttagacaa gtccactttt tcaggagcca
    49321 attttttcaa cttggccttg gcttcaatga tttcgtgggg cttgagttgg gatttactgt
    49381 ggagattttt gagaatctgg tcactttcac ttagggccat atccacaatc tcagcagcct
    49441 gttcacgcgc cttgttaagc tcggtttcct tttcacgatt aagctcgttg tagagttttt
    49501 ttagcgcacg gttcatcttg agattttctt gctccacctc acggatattg tccaaacgtt
    49561 tgcggctttc cagcgtctgc tcttctaatt gctcaatgat acgattgacg tcattgtcct
    49621 gatcgatctg ctgactggca tctcctacga taacttcaga taggcctaga cgtttggcaa
    49681 tttcaaaggc attacttcgg ccaggaacac cctgcataaa gcgataggtc gggcgaagag
    49741 ttgcagtatc aaactccata ctggcatttt gcacaaaggc tgtctcaata ccgtaggcct
    49801 tgagttctgg atagtgggtc gtcgccatgg tcttgatttg acgcaggcga aggtcctcca
    49861 gaatagccat ggcaagggct gctccctctt ggggatcagt accagccccc aactcatcca
    49921 aaagtaagag tgaatgttgg ttgaccttgc caagaatatc cacgatattg gtcatatggc
    49981 tagagaaggt agacaagctc tgctcaatag actgctcatc tccaatatca gcaaagattt
    50041 cttcaaaaat accaacacga cttcccttgt ctgctaaaat cggcaatcct gactgggcca
    50101 tgacctgtgt caagcccaga gttttgagca tgatggtctt cccacctgta ttgggacctg
    50161 taatgacaat agctgttaaa tcttgaccaa aatggacatc atttgcgacg gcatttttga
    50221 ccaaaggatg gcagacatgg agcagttgaa tctcttgatt ttctgacagc tgaggcacga
    50281 ctgcttgtct ttcttggata aatcgaacct tggcacgaat caagtccaga tgaccgataa
    50341 tccaagcgtc attagcaatc tcagccgcat gagggcggac acgctcagaa atttcttgga
    50401 gaatgcgaag catttcatag cgctcatctg ctcgcagact agcaatttct tcgctcagtt
    50461 tgactacctc acgtggttcg atatagacgg tgtttccact agcagaaata tcatgaacga
    50521 cacctgcaat cttattgcgg taggtgtttt tgactggtaa aacctgacgg ccatttctgc
    50581 tagcaacaat tccttccgtc aacatctgcg ctttttgctt gagcaagtct tgtaaaacat
    50641 cgcgtacctg actctcgcta tcatgtattt ttcgacggat tcgcgccaat tcttcactgg
    50701 caaaattttc aatgaaaccc gcatcattaa aggcctgaag atttccttgt aattgcggaa
    50761 aatcatgtaa tttctcaaac caaagggcta attcttccaa gctgacattt tccagattgg
    50821 tgtaaaaatt ttgaagttct cggctggcaa gaagcacgcg tttcaagagt aggaactcct
    50881 cgatattgag atccgctccc atctccaacc tcttgcagac tcctgcaatt tccttagttg
    50941 agagaatagt aaaatgcggt tgctcgacga aaagagcctg catttccttc atctcagcaa
    51001 aagcctgttt gattttatct gctttggcag tcggagccag ttgtctcaat tgctccaagc
    51061 cctgctcggt caacaaatga ggctcaaaca aggccttgac cttatcgaac tctaatgttt
    51121 ctaatatttt cttattcatc tttatttcct tgtctttgaa tgtctaggtg tggtagcttt
    51181 ttacattctg atagattcga gtcaaatctg taaacaaagg gctaggaaaa ctcctgccct
    51241 ttttatccga ttaaatttgt cacccagatt tgtttgagcc aactggttgt tatcggtatg
    51301 ctctggatga tgtgttttgc gacgatactc ttttcaagag gattttgtat aactgccatg
    51361 gggatggtcg ccaagattgt caaggccatt tgcaagacaa ataaggtcac caacatggac
    51421 aagatacctg ctgaaacttg gaacaactta ccacccagtt ttttgctagg aatcaagtgt
    51481 aagagaagac caagcaaacg accaatgcta tagacaatcc caaatacaag caagtagccg
    51541 atacctgcat aaaagacctt atccagctga aagagttgat ccgatgggaa aaagaaagtc
    51601 ccctgacctt cctgcgaatt tgcataaggg agcaataaat ggaattgctc tccaagcccc
    51661 ttataaaact ggccagccat aaaagccgat gccatggctg aaatcaggta ataaacctgt
    51721 aagagcaggc ctctccgata gccgatataa aatccccaaa ccaagaccaa tagaagaagg
    51781 aatgaaatca taaggaatcc tcaatcttgc tctgttcttg cttacaagtc acaagcttgt
    51841 gacggagttc ttctagctct tgctccttat cgtcaaattc aatctcacgg ctgagctgag
    51901 ttgataaaca gttgactgcc aacaaaagag cgattgtttc atcatctgcg ctaggcattt
    51961 gttctttaat tgcttggtat ttttctgtcg caaccttagc gatttcctcc ataaaaaggt
    52021 tatcatgttc gcttgtcaag gttaacgatt ttttcccgaa tgtaaatttg aatcgattta
    52081 gatttgccat aaaattcacc tcacgatatt ataccaaaat tcgctaattt tgtcagtttt
    52141 tacaaatttt actgcttttg tggtacaata gaaactatgg caagtatcac actcacacca
    52201 agcgaaaagg atattcaggc ttttcttgaa cactatcaaa ccagtctggc tcccagtaag
    52261 aatccctata tccgctactt tttgaaacta cctcaagcaa cggtttctat ctatacttct
    52321 ggaaaaatct tgcttcaggg tgaaggggct gagaaatacg ctagtttctt tggctatcaa
    52381 gctgtagagc aaaccagcgg acaaaatctt cctttaattg ggacagatga ggtgggaaat
    52441 ggttcctact ttggtgggct tgcagttgtg gctgcctttg tcacatctga ccagcacgac
    52501 tttttacgaa aactcggtgt gggggattct aagactctga ccgaccaaaa gatccgtcag
    52561 attgctccta ttctcaagga aaaaatccag caccaggcac tccttctctc acccagcaag
    52621 tacaacgagg tcatcggaga ccgctacaat gctgtttcgg ttaaggttgc cctccataat
    52681 caggctatct atctcctcct tcaaaaaggt gttcagcctg agaaaattgt gattgatgcc
    52741 tttaccagtg ctaaaaatta tgacaagtac ttggcacaag aggccaatcg tttcagcaat
    52801 cctatcagct tagaagaaaa ggctgagggc aaatacttgt ctgtcgcagt ttcttctgtc
    52861 attgcgcgtg atctctttct ggaaaatctt gaaaatttgg gacgagaact gggttatcag
    52921 ctcccaagtg gagctggaac ggcttctgac aaggtggcta gccagatttt gcaagcctat
    52981 ggtatgcagg gactcagctt ctgcgccaaa ttgcacttta aaaacactga aaaagcgaaa
    53041 aaacgcttag aaaggtaagt tatgaattca tttaaaaatt tcttaaaaga gtggggattg
    53101 ttcctcctaa ttctgtcatt actagcttta agtcgtatct ttttttggag caatgttcgc
    53161 gtagaaggac attccatgga tccgacccta gcggatggcg aaattctctt cgttgtaaaa
    53221 caccttccta ttgaccgttt tgatatcgtg gtggcccatg aggaagatgg caataaggac
    53281 atcgtcaagc gcgtgattgg aatgcctggc gacaccattc gttacgaaaa tgataaactc
    53341 tacatcaatg acaaagaaac ggacgagcct tatctagcag actatatcaa acgcttcaag
    53401 gatgacaaac tccaaagcac ttactcaggc aagggctttg aaggaaataa aggaactttc
    53461 tttagaagta tcgctcaaaa agcccaagcc ttcacagttg atgtcaacta caacaccaac
    53521 tttagcttta ctgttccaga aggagaatac cttctcctcg gagatgaccg cttggtttcg
    53581 agcgacagcc gccacgtagg taccttcaaa gcaaaagata tcacagggga agctaaattc
    53641 cgcttctggc caatcacccg tatcggaaca ttttaagaaa cctaagaggc cgagaatcac
    53701 caatctcagc ctcttcttct atcgtgagaa aatgattggt aactatctaa acttaccaga
    53761 acagaaacac ctcaactctc acctattcat gcaaaggaat tttatggaag tttatttttc
    53821 aggaaccatt gaacggatta tttttgaaaa tcccagcaat ttttatcgca tcctcctcct
    53881 agaaatcgac gatacggacg cagaggattt tgatgatttt gaaatcattg tcacaggaac
    53941 catggctgat gtaattgagg gcgaagacta tactttttgg gggcaaattg tccagcactc
    54001 caagtatgga gaacaactgc aaatcagtcg ttatgatcgc gcaaaaccaa ctagtaaggg
    54061 cttggtcaag tacttttcaa gtagccattt caaggggatt ggtctcaaga cagctcagaa
    54121 aatcgtggat acctatggcg aaaataccat tgacgaaatt ttgcaacacc cagaaaagtt
    54181 agaaggcatc gcaggactct ctgccaaaaa tcgcgaggct ttcgtctcca ctctccgtct
    54241 caactacgga acggagatgg ttttgtccaa actagccaac tacggcattc ccaacaaact
    54301 agcctttcag attcaagact tttacaagga agaaaccctt gatgtggttg aaaattatcc
    54361 ctaccagctg gttgaggata tcaagggttt gggctttacc attgctgacc aactagctga
    54421 ggaactaggc atcgaaagtc aggctcctga acgcttccgc gccggtctag ttcacagtct
    54481 ttttcaggcc tgtatggaaa caggggacac ctatgttgaa gcacgggatt tgctggaaca
    54541 aacccttact ctccttgagt cttcccgtcc cgtggaacta gaccccggcc aagttgccca
    54601 agagctctcc tacctgatcg aagaagacaa ggttcagcag attgatacca agatctttga
    54661 caacagcctc tttttcgctg aggaaggtat ccgcagtcac ttgattcgta tccttgaaaa
    54721 aggaaaacag aagagccaag atttagaaac tattcaaaag catatcacta ctgtcgagca
    54781 agaactgggg attgagtatg ataacattca aaaacaggct atctgtgatg ctatccagaa
    54841 taaggtcttt atcctgacag gtggacctgg tactggtaag acaactgtta tcaatgggat
    54901 catcgctgtt tacgccctgt tagagggact tgacctcagg aagaaaagca acctgcccat
    54961 tcttcttgct gctccaactg gtcgagctgc tcgtcgcatg aatgaattga caggtttgcc
    55021 tagcgcgacc atacaccgcc acttgggaat gacaggtgac gatgatacca gtcatctgga
    55081 agattaccta gatgctgact ttatcatcgt ggatgaattc tctatggtgg atacttggct
    55141 ggccaatcaa ctcttctcca atatctcttc taacagtaag atcctcatcg taggtgacag
    55201 tgatcagcta ccttctgtca gtcctggaca ggttctagcg gatctgcttc atattccttt
    55261 gattcctcag actcgcttgg aaaaaattta tcgacaaagc gaagaatcaa ccatcgtcac
    55321 cctagctagt cagattcgac agggcatctt gccagctgat ttcacccaaa aaaaagctga
    55381 ccgttcctac tttgaaattg ctagtggcca tattcctgcc actattgaaa aaatcttagg
    55441 tgccgccctc agaaatagta ttcctgccca tgatatccaa gttctggctc ctatgtaccg
    55501 agggacggca gggattgatg ctatcaatca gctcatgcaa gacctgctca atcccccaca
    55561 aaaagatcaa ctcagttttg aagctcctca gtgccactat cgtaagggag acaaggtcat
    55621 tcatttggtt aacgatgctg aaatcaatgt ctttaatggg gatttaggag ctatcacaga
    55681 cctgattcct ggtaaataca ccgaatcgaa acaagacgag attgtcattg attttgatgg
    55741 taatgaagtc tcttaccccc gtaacgaatg gtacaagatt cgcttggcct atgccatgag
    55801 tattcataag tctcagggaa gtgagttccc agttgtcatc ctaccgatta ctagtgctag
    55861 ccgacgtatg ctggagcgaa atctcatcta cacagccatt acacgtgcca aaagcaaact
    55921 catcttacta ggcgaattac aagccttcga ctatgctacc caacacatcg gaactgcccg
    55981 aaaaacctat ctgattgaac gcttcagtga tctactggag aatgttgaag aaaagcaaca
    56041 agctgtctct gaaacagtca catcaagtgc ctctgaacaa tcctacatcc taaccgaaga
    56101 aaactgggac cgcatcccag ccatgattgg gattacagac acagacctca aagagatttt
    56161 tggaaaatag tgcatcagaa aacccaccaa ttcaggtggg ttttctgttt attaagatta
    56221 ttttactgtt gctgtgcttg tgatcaattc aacagctttt ttgatagtga tatcatgttt
    56281 caacatgtca gctgaaagca agttttgaac ttgtgcaact tccatgttgt agtctgctgc
    56341 caattgctca acttcttttt ggatttcttc ttctgaagca tcaaatcctt cagctttggc
    56401 aactgcttcg ataacaaggt tagtcttagt acgtgactca gcttctgctt ggtattggtt
    56461 gtgaaggtct tcttgagtag ttccagtgat ttggaagtac atgtcagggt tgatcccttg
    56521 acgttgcaaa ttcccaagga attcatttac tgaacggtga acttcttcat ggatcatttc
    56581 ttctggaagt tctacgattt cagcattttc tacagctgta tcaattgctg caccttcaac
    56641 tgcatctttg taagcttctt ctttagcagc agccaattct ttgcggtatt tttctttcaa
    56701 gtcagcaagt gtttcaactt cttcatcaat gtcttttgca agttcatcgt caagagctgg
    56761 aacttcttta gcttttactt cgtggatagt tgtcacgaat ttagcttctt tacctgcaag
    56821 gtcttctgct tggtagtctt ctgggaatgt tacgataaca tcaacggttt cgccagctga
    56881 gtgacctacc aattggtctt cgaaaccagg gatgaattga cctgaaccaa gtccaagtga
    56941 gaagttttca ccttttccgc cgtcaaattc aacaccgtcg atagaaccaa cgaagtcgat
    57001 cacaacagtg tcgccgtttt cagcagcagc ttccttgata accaattcag ccaggttgtt
    57061 gcgttcgcgt tcgatacgct cttcaacatc agcgtcagtt acttcttttt ctacatcaac
    57121 tgatacttca aggtttttgt agtcacccaa ttttacttca ggttttgtaa cgacttcagc
    57181 agcgataacc cagtcttgac ctttttccat tgaagttacg tcaatttttg gttgggcaac
    57241 cacttcaaga ccagcttctt ttacagctgc ttcataagcg tttggcaaaa gagcgttcat
    57301 aacgtcttgg taaagtgatt cttcaccaaa ttttttatcg aagataggac gtggaaggtg
    57361 acctttacgg aaacctggaa cattaagaga tttcttcact gacttgaaga cacggtccaa
    57421 ttctggtttg atttggtctt gagagatagt gaaagtcaag acaccacggt ttgtttcttt
    57481 gttttcaaat gatacagaca ttctgtcatt tctccttaaa attttttaa
//
LOCUS       DAVLHC010000008        53590 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.008, whole genome shotgun sequence.
ACCESSION   DAVLHC010000008 DAVLHC010000000
VERSION     DAVLHC010000008.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 53590)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 53590)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..53590
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.008"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(43..2589)
                     /locus_tag="VXE25_000502"
     CDS             complement(43..2589)
                     /locus_tag="VXE25_000502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001149089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M1 family metallopeptidase"
                     /protein_id="HEV0771021.1"
                     /translation="MQAVEHFIKQFVPEHYDLFLDLSRETKTFSGKVTITGQAQSDRI
                     SLHQKDLEITSVEVAGQARPFTVDHDNEALHIELAEAGQVELVLAFSGKITDNMTGIY
                     PSYYTVDGVKKEVLSTQFESHFAREAFPCVDEPEAKATFDLSLRFDQAEGELALSNMP
                     EIDVENRKETGIWKFETTPRMSSYLLAFVAGDLQGVTAKTKNGTLVGVYSTKAHPLSN
                     LDFSLDIAVRSIEFYEDYYGVKYPIPQSLHIALPDFSAGAMENWGLVTYREVYLVVDE
                     NSTFASRQQVALVVAHELAHQWFGNLVTMKWWDDLWLNESFANMMEYVCVDTIEPSWN
                     IFEDFQTGGVPLALERDATDGVQSVHVEVKHPDEINTLFDGAIVYAKGSRLMHMLRRW
                     LGDADFAKGLHAYFEKHQYSNTIGSDLWDALGQASGRDVAAFMDSWLEQPGYPVLTVK
                     VENDVLKISQKQFFIGENEDKNRLWVVPLNSNWKGLPDTLETESIEIPGYAALLAENE
                     GALRLNTENTAHYITDYQGDLLAAVLAELETLDNTSKLQIVQERRLLAEAGHISYADL
                     LPVLDKLAKEESYLVVSAVSQVISALERFIDEGTDAETAFKGLVAKLARHNYDRLGFE
                     AKDGESDEDELVRQLAVSMMIRSNDAEASQVASQIFATHKENLAGLPAAIRSQVLINE
                     MKHHETKDLLALYLDTYTHATDAVFKRQLAAALAYSTDADNIQNLITSWKDKFVVKPQ
                     DLSAWYYQFLAHQATQKTAWSWARENWAWIKAALGGDMSFDSFVILPAHVFKTQQRLA
                     EYKEFFEPQLSDLALSRNIGMGIKEIAARVDLISREKAAVEAVVLQYGNA"
     gene            complement(2712..3152)
                     /locus_tag="VXE25_000503"
     CDS             complement(2712..3152)
                     /locus_tag="VXE25_000503"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512572.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ASCH domain-containing protein"
                     /protein_id="HEV0771022.1"
                     /translation="MIPQEMWNKYKQINPLIGDEIDAWAFGVEPDLLADLVFKGEKTA
                     TASAYDLYVLEDEPLPQVGTFDVILDSQNQSVCIVEITKVSVELFNQVSAQHAFKEGE
                     GDKSLAYWRQIHEDFFTDCLGEVGLTFTPESKVVLEEFRKVYPL"
     gene            complement(3127..3996)
                     /locus_tag="VXE25_000504"
     CDS             complement(3127..3996)
                     /locus_tag="VXE25_000504"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PEP-utilizing enzyme, TIM barrel domain protein"
                     /protein_id="HEV0771023.1"
                     /translation="MRNQLALSGEKILEKIYPQLFHHVGMIRGEYLLRELNQNIILAS
                     CQQFVKDYLETICSLYSDEEVWYCFTELTNTEANCLVGTKEFFDEGHPLFGYRGTRRL
                     LACLDEFQAEAHVVTEVYQTNPNLSLIFPFVNDADQLKQAITVLRQYGFTGKVGTMIE
                     LPSAYFDLSSILETGISKIVVGINDLTSFVFATMRNSQWHDLESPIMLDMLRDMQDKA
                     RKNKINFAVAGYLNTSFIQKMNQLGIKCIIHYSSIPEIFDLEIDHPDHLKHIKEESKK
                     LQRSTHDTARNVE"
     gene            complement(3974..4474)
                     /locus_tag="VXE25_000505"
     CDS             complement(3974..4474)
                     /locus_tag="VXE25_000505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000403615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HEV0771024.1"
                     /translation="MEIKKHFGVYAVCLENGKLLCIEKARGPYQHRYDLPGGSQQLGE
                     GLTETLTREVMEETGFTVRSYSNPRIYDVFVREELTNFMVHHVMALYDVEMNESAPQV
                     TTSEAVSDGANDSLGYIWMDIQEITEENASPLVLKVKSELLGFPELDKTSYMNWKVND
                     EKSTCP"
     gene            complement(4485..5183)
                     /locus_tag="VXE25_000506"
     CDS             complement(4485..5183)
                     /locus_tag="VXE25_000506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacyl-ACP reductase"
                     /protein_id="HEV0771025.1"
                     /translation="MTKRVLITGVSSGIGLAQARLFLEKGYQVYGVDQGEKPLLEGDF
                     HFLQRDLTLDLEPIFDWCPQVDVLCNTAGVLDDYKPLLEQTAQDIQEIFEINYIIPVE
                     LTRYYLTQMLENKKGIIINMCSIASSLAGGGGHAYTSSKHALAGFTKQLALDYAEAGI
                     QVFGIAPGAVKTAMTAADFEPGGLADWVASETPIKRWIEPEEIAELSLFLASGKASAM
                     QGQILTIDGGWSLK"
     gene            complement(5176..5442)
                     /locus_tag="VXE25_000507"
     CDS             complement(5176..5442)
                     /locus_tag="VXE25_000507"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2829 domain-containing protein"
                     /protein_id="HEV0771026.1"
                     /translation="MKNVELKEKNMTFEEILPGLKAKRKYVRTGWGGAENYVQLFDTI
                     EQNGLALEMTPYFLINVSGEGEGFSMWSPTACDVLATDWVEVHD"
     gene            complement(5510..6436)
                     /locus_tag="VXE25_000508"
     CDS             complement(5510..6436)
                     /locus_tag="VXE25_000508"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001269463.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldo/keto reductase family oxidoreductase"
                     /protein_id="HEV0771027.1"
                     /translation="MRYITLGQDDKELSEIVLGMMRIKDKSVKEVEELVETALSVGIN
                     AFDLADIYGRGRCEELLGLVLKNRPDLREKMWIQSKCGIRIEEFTYFDFSKDYIIKSV
                     DGILQRLKIDHLDSLLLHRPDALMESDQVAEAFDLLYKQGKVRDFGVSNQNPMMMELL
                     KKDVKQPLAVNQLQLSAAFTPGFESAFHVNMEDSQAAMRDGSIFEYCKLHDVVIQAWS
                     VLQFGYFKGNFVGNEKFQALNQVLDRLAIKYGVTSSTIAISWILRYPAKMQAVVGTTN
                     PKHLREVSQAANFSLTRKEWYEIYLAAGNNLP"
     gene            complement(6511..7326)
                     /locus_tag="VXE25_000509"
     CDS             complement(6511..7326)
                     /locus_tag="VXE25_000509"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771028.1"
                     /translation="MKKMKYYEETSALLHEFSEENQKYFEELWESFNLVGFLYDEDYL
                     REQIYLMMLDFSEAERDGMSAEDYLGKNPKKIMKEILKGAPRSSIKESLLTPILVLAV
                     LRYYQLLSDFSKGPLLTVNLLTFLGQLLIFLIGFGLVVTILRRSLVQDSPKMKIGTYI
                     VVGTIVLLVVLGYVGMASFIQEGAFYIPAPWDSLSVFTISLVIGIWNWKEAVFRPFVS
                     MIIAHLVVGSLLRYYEWMGISNVFLTKVIPLAVLFIGIFVLFRGFKKIKWSEV"
     gene            complement(7330..7650)
                     /locus_tag="VXE25_000510"
     CDS             complement(7330..7650)
                     /locus_tag="VXE25_000510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000665424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="HEV0771029.1"
                     /translation="MKETQLLKGVLEGCVLDMIGQKERYGYELVQTLREAGFDTIVPG
                     TIYPLLQKLEKNQWIRGDMRPSPDGPDRKYFSLMKEGEERVSVFWQQWDDLSQKVEGI
                     KNGG"
     gene            complement(8037..8117)
                     /locus_tag="VXE25_000511"
                     /pseudo
     CDS             complement(8037..8117)
                     /locus_tag="VXE25_000511"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            complement(8161..10158)
                     /gene="metG"
                     /locus_tag="VXE25_000512"
     CDS             complement(8161..10158)
                     /gene="metG"
                     /locus_tag="VXE25_000512"
                     /EC_number="6.1.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006155678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine--tRNA ligase"
                     /protein_id="HEV0771030.1"
                     /translation="MSEKNFYITTPIYYPSGKLHIGSAYTTIACDVLARYKRLMGYDV
                     FYLTGLDEHGQKIQQKAEEAGITPQVYVDRMAVGVKELWQLLDISYDKFIRTTDDYHE
                     KVVAQVFERLLAQDDIYLGEYSGWYSVSDEEFFTESQLAEVFRDEAGNVTGGIAPSGH
                     EVEWVSEESYFLRLSKYQDRLVEFFKAHPEFITPDGRLNEMLRNFIEPGLEDLAVSRT
                     TFTWGVPVPSNPKHVVYVWIDALLNYATALGYAQDEHGNFDKFWNGTVFHMVGKDILR
                     FHSIYWPILLMMLDVKLPDRLIAHGWFVMKDGKMSKSKGNVVYPEMLVERYGLDPLRY
                     YLMRNLPVGSDGTFTPEDYVGRINYELANDLGNLLNRTVSMINKYFDGQIPAYVEGVT
                     EFDHVLAEVAEQSIADFHTHMEAVDYPRALEAVWTLISRTNKYIDETAPWVLAKDEAL
                     RDQLASVMSHLAASIRVVAHLIEPFMMETSRAVLTQLGLEEVSSLENLSLADFPADVT
                     VVAKGTPIFPRLNMEEEIAYIKEQMEGNKPAVEKEWNPDEVELKLNKDEIKFEDFDKV
                     EIRVAEVKEVSKVEVSDKLLQFRLDAGDGEDRQILSGIAKYYPNEQELVGKKVQIVAN
                     LKPRKMMKKYVSQGMILSAEHDGKLTLLTVDPAVPNGSVIG"
     gene            complement(10282..11541)
                     /locus_tag="VXE25_000513"
     CDS             complement(10282..11541)
                     /locus_tag="VXE25_000513"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001180420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEV0771031.1"
                     /translation="MQNLKFAFSSIMAHKMRSLLTMIGIIIGVSSVVVIMALGDSLSR
                     QVNKDMTKSQKNISVFFSPKKSKDGSFTQKQSAFTVSGKEEEVPVEPPKPQESWVQEA
                     AKLKGVDSYYVTNSTNAILTYQDKKVENANLTGGNRTYMDAVKNEIIAGRSLREQDFK
                     EFASVILLDEELSISLFESPQEAINKVVEVNGFSYRVIGVYTSPEAKRSKIYGFGGLP
                     ITTNISLAANFNIDEIASIVFRVNDTSLTPTLGPELARKMTELAGLQQGEYQVADESV
                     VFAEIQQSFSFMTTIISSIAGISLFVGGTGVMNIMLVSVTERTREIGLRKALGATRAN
                     ILIQFLIESMILTLLGGLIGLTIASGLTALAGLLLQGLIEGIEVGVSIPVALFSLAVS
                     ASVGMIFGVLPANKASKLDPIEALRYE"
     gene            complement(11543..12244)
                     /locus_tag="VXE25_000514"
     CDS             complement(11543..12244)
                     /locus_tag="VXE25_000514"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0771032.1"
                     /translation="MKQLISLKNIFRSYRNGDQELQVLKNINLEVNEGEFVAIMGPSG
                     SGKSTLMNTIGMLDTPTSGEYYLEGQEVAGLGEKQLAKVRNQQIGFVFQQFFLLSKLN
                     ALQNVELPLIYAGVSSSKRRKLAEEYLDKVELTERSHHLPSELSGGQKQRVAIARALV
                     NNPSIILADEPTGALDTKTGNQIMQLLVDLNKEGKTIIMVTHEPEIAAYAKRQIVIRD
                     GVISSDSAQLGKEEN"
     gene            complement(12228..13427)
                     /locus_tag="VXE25_000515"
     CDS             complement(12228..13427)
                     /locus_tag="VXE25_000515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728654.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="efflux RND transporter periplasmic adaptor
                     subunit"
                     /protein_id="HEV0771033.1"
                     /translation="MKKKNGKAKKWQLYAAIGAASVVVLGAGGILLFRQPSQTAVKDE
                     PTHLVVAKEGSVASSVLLSGTVTAKNEQYVYFDASKGDLDEILVSVGDKVSEGQALVK
                     YSSSEAQAAYDSASRAVAKADRHINELNQARNEAASAQAPQLPAPVGGEDATVQSPTP
                     VAGNSVASIDAQLGDARDARADAAAQLSKAQSQLDATTVLSTLEGTVVEVNSNVSKSP
                     TGASQVMVHIVSNENLQVKGELSEYNLANLSVGQEVSFTSKVYPDKKWTGKLSYISDY
                     PKNNGEAASPAAGNNTGSKYPYTIDVTGEVGDLKQGFSVNIEVKSKTKAILVPVSSLV
                     MDDSKNYVWIVDEQQKAKKVEVSLGNADAENQEITSGLTNGAKVISNPTSSLEEGKEV
                     KADEATN"
     gene            13713..15059
                     /gene="gor"
                     /locus_tag="VXE25_000516"
     CDS             13713..15059
                     /gene="gor"
                     /locus_tag="VXE25_000516"
                     /EC_number="1.8.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutathione-disulfide reductase"
                     /protein_id="HEV0771034.1"
                     /translation="MREYDIIAIGGGSGGIATMNRAGEHGVKAAVIEEKKLGGTCVNV
                     GCVPKKIMWYGAQVAETFHQFGEDYGFKTTDLNFDFATLRRNREAYIDRARSSYDGSF
                     KRNGVDLIEGHAEFVDSHTVSVNGELIRAKHIVIATGAHPSIPNIPGAELGGSSDDVF
                     AWEELPESVAILGAGYIAVELAGVLHTFGVKTDLFVRRDRPLRGFDSYIVEGLVKEME
                     RTNLPLHTHKVPVKLEKTTDGITIHFEDGTSHTASQVIWATGRRPNVKGLQLEKAGVT
                     LNERGFIQVDEYQNTVVEGIYALGDVTGEKELTPVAIKAGRTLSERLFNGKTTAKMDY
                     STIPTVVFSHPAIGTVGLTEEQAIKEYGQDQIKVYKSSFTSMYSACTCNRQETRFKLI
                     TAGSEEKVVGLHGIGYGVDEMIQGFAVAIKMGATKADFDATVAIHPTSSEEFVTMR"
     gene            15256..15792
                     /locus_tag="VXE25_000517"
     CDS             15256..15792
                     /locus_tag="VXE25_000517"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000709035.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biotin transporter BioY"
                     /protein_id="HEV0771035.1"
                     /translation="MKKAHVYAIPAIGAALIAVLAQISLPIGPVPFTLQNFAIGLIAT
                     VFRPREAVLSAGLYLLLGAIGLPVFAGGGAGFQALVGPTAGYLWFYLVYSGLTSSLTN
                     SKSGVVKIFLANLLGDALVFVGGILSLHFLAGMAFEKALVVGVLPFIIPDLGKLLAIS
                     FISRPLLQRLKNQAYFTN"
     gene            15847..15927
                     /locus_tag="VXE25_000518"
                     /pseudo
     CDS             15847..15927
                     /locus_tag="VXE25_000518"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            complement(15996..16211)
                     /locus_tag="VXE25_000519"
     CDS             complement(15996..16211)
                     /locus_tag="VXE25_000519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000807422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdbC family protein"
                     /protein_id="HEV0771036.1"
                     /translation="MAEFTFEIEEHLLTLSENEKGWTKEINRVSFNGAPAKFDIRAWS
                     PDHTKMGKGITLSNEEFQTMVDAFKGN"
     gene            16309..16629
                     /locus_tag="VXE25_000520"
     CDS             16309..16629
                     /locus_tag="VXE25_000520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001216095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771037.1"
                     /translation="MRHKFQQVLNKIHDFLNGYDQPDQTETNSLTATIEEAIQKQTAV
                     HLILSETSFTGDIIKYDQQGQQIIVKNFSKNVSRIIRISDIQRLRFVPSTVQTAQKNR
                     FKKE"
     gene            complement(16659..16997)
                     /locus_tag="VXE25_000521"
     CDS             complement(16659..16997)
                     /locus_tag="VXE25_000521"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001196050.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771038.1"
                     /translation="MQVIKRNGEIAEFNPDKIYQAILKAAQTVYVLTDDLRQNLAQVT
                     KKVVLDLQEAKVERATISMIQSMVEHRLLGAGYITIAEHYISYRLQRDLERSGYGDHI
                     AVHLHFEQIR"
     gene            complement(17009..17728)
                     /gene="trmD"
                     /locus_tag="VXE25_000522"
     CDS             complement(17009..17728)
                     /gene="trmD"
                     /locus_tag="VXE25_000522"
                     /EC_number="2.1.1.228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanosine(37)-N1)-methyltransferase TrmD"
                     /protein_id="HEV0771039.1"
                     /translation="MKIDILTLFPEMFSPLEHSIVGKAREKGLLDIQYHNFRENAEKA
                     RHVDDEPYGGGQGMLLRVQPIFDSFDAIEKKNPRVILLDPAGKQFDQAYAEDLAQEEE
                     LIFICGHYEGYDERIKTLVTDEISLGDYVLTGGELAAMTMIDATVRLIPEVIGKESSH
                     QDDSFSSGLLEYPQYTRPYDYRGMVVPDVLMSGHHEKIRQWRLYESLKKTYERRPDLL
                     EHYQLTVEEEKMLAEIKENKE"
     gene            complement(17718..18236)
                     /gene="rimM"
                     /locus_tag="VXE25_000523"
     CDS             complement(17718..18236)
                     /gene="rimM"
                     /locus_tag="VXE25_000523"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465641.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome maturation factor RimM"
                     /protein_id="HEV0771040.1"
                     /translation="MNYFNVGKIVNTQGLQGEMRVLSVTDFAEERFKKGAELALFDEK
                     DQFVQTVTIASHRKQKNFDIIKFKDMYHINTIEKYKGYSLKVAEEDLNDLDDGEFYYH
                     EIIGLEVYEGDSLVGTIKEILQPGANDVWVVKRKGKRDLLLPYIPPVVLNVDIPNKRV
                     DVEILEGLDDED"
     gene            complement(18341..18626)
                     /locus_tag="VXE25_000524"
                     /pseudo
     CDS             complement(18341..18626)
                     /locus_tag="VXE25_000524"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001822175.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
     gene            complement(18627..19055)
                     /locus_tag="VXE25_000525"
     CDS             complement(18627..19055)
                     /locus_tag="VXE25_000525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000819192.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HEV0771041.1"
                     /translation="MKRFEVSTEIGSLSVTYQKQKKVLVCLNGAGLLPSYENFSLILE
                     KPPPTIGYLTIDFPNTGRSPIHDQAGKKLDNLADAVYEVLEELGISEYILCAHSWSGI
                     LACKLLEKPIKRQTLVAIEPTTKKVMFADFSENPYPEMEE"
     gene            complement(19632..19871)
                     /locus_tag="VXE25_000526"
     CDS             complement(19632..19871)
                     /locus_tag="VXE25_000526"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005590445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="KH domain-containing protein"
                     /protein_id="HEV0771042.1"
                     /translation="MDTIENLIIAIVKPLISQPDALTIKIEDTPEFLEYHLNLDQSDV
                     GRVIGRKGRTISAIRTIVYSVPTEYKKVRIVIDEK"
     gene            complement(19891..20163)
                     /gene="rpsP"
                     /locus_tag="VXE25_000527"
     CDS             complement(19891..20163)
                     /gene="rpsP"
                     /locus_tag="VXE25_000527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002884675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S16"
                     /protein_id="HEV0771043.1"
                     /translation="MAVKIRLTRMGSKKKPFYRINVADSRSPRDGRFIETVGTYNPLV
                     AENQVTLKEDRVLAWLANGAQPSDTVRNILSKEGVLKKFHDSKFSK"
     gene            20342..20542
                     /locus_tag="VXE25_000528"
     CDS             20342..20542
                     /locus_tag="VXE25_000528"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001092275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771044.1"
                     /translation="MNTILEKFYKEHQVKPFISPERDLDTWLLSPKPVPKRNMDLLAD
                     DSLAGDIILLWRIQFGTFTTET"
     gene            21021..21233
                     /locus_tag="VXE25_000529"
     CDS             21021..21233
                     /locus_tag="VXE25_000529"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771045.1"
                     /translation="MSFYGLFYNGIAITPNTYLSAWFVNFIAALPLNFLIVEPIARFI
                     LSSFQKPFTGEEVEDFQDDDEIPTII"
     gene            21316..22119
                     /locus_tag="VXE25_000530"
     CDS             21316..22119
                     /locus_tag="VXE25_000530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000731914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HEV0771046.1"
                     /translation="MKKLATLLLLSTVALAGCSSVQRSLRGDDYVDSSLAAEESSKVA
                     AQSAKELNDALTNENANFPQLSKEVAEDEAEVILHTSQGDIRIKLFPKLAPLAVENFL
                     THAKEGYYNGITFHRVIDGFMVQTGDPKGDGTGGQSIWHDKDKTKDKGTGFKNEITPY
                     LYNIRGALAMANTGQPNTNGSQFFINQNSTDTSSKLPTSKYPQKIIEAYKEGGNPSLD
                     GKHPVFGQVIDGMDVVDKIAKAEKDEKDKPTTAITINSIEVVKDYDFKS"
     gene            complement(22176..23717)
                     /locus_tag="VXE25_000531"
     CDS             complement(22176..23717)
                     /locus_tag="VXE25_000531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002918612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HEV0771047.1"
                     /translation="MSILEVKNLSHGFGDRAIFEDVSFRLLKGEHIGLVGANGEGKST
                     FMSIVTGKMLPDEGKVEWSKYVTAGYLDQHSVLAERQSVRDVLRTAFDELFKAEARIN
                     DLYMKMAEDGADVDALMEEVGELQDRLESRDFYTLDAKIDEVARALGVMDFGMDTDVT
                     SLSGGQRTKVLLAKLLLEKPDILLLDEPTNYLDAEHIDWLKRYLQNYENAFVLISHDI
                     PFLNDVINIVYHVENQQLTRYSGDYYQFQEVYAMKKSQLEAAYERQQKEIADLKDFVA
                     RNKARVATRNMAMSRQKKLDKMDIIELQSEKPKPSFDFKPARTPGRFIFQAKNLQIGY
                     DRPLTKPLNLTFERNQKVAIIGANGIGKTTLLKSLLGIISPIAGEVERGDYLELGYFE
                     QEVEGGNRQTPLEAVWNAFPALNQAEVRAALARCGLTTKHIESQIQVLSGGEQAKVRF
                     CLLMNRENNVLVLDEPTNHLDVDAKDELKRALKEYRGSILMVCHEPDFYEGWIDQIWD
                     FNNLT"
     gene            complement(23719..24201)
                     /locus_tag="VXE25_000532"
     CDS             complement(23719..24201)
                     /locus_tag="VXE25_000532"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000976721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanZ family protein"
                     /protein_id="HEV0771048.1"
                     /translation="MMKKTYNHILVWGVIFYSICIVCFCFTPQEQSTVGVGTPDIQHL
                     GRLVFLLTPFNSLWKLGEVSDIGQLCWIFLQNILNVFLFFPLIFQLLYLFPNLRKTKK
                     VLLFSFLVSLGIECTQLILDFFFDFNRVFEIDDLWTNTLGGYLAWLLYKRLHKNKIRN
                     "
     gene            complement(24201..25286)
                     /gene="rlmN"
                     /locus_tag="VXE25_000533"
     CDS             complement(24201..25286)
                     /gene="rlmN"
                     /locus_tag="VXE25_000533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000804770.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (adenine(2503)-C(2))-methyltransferase
                     RlmN"
                     /protein_id="HEV0771049.1"
                     /translation="MKPSIHSLAHQTMQEWVLEQGEKKFRADQIWEWLYRKRVQSFEE
                     MTNLSKDLIAKLNDQFVVNPLKQGIVQESADGTVKYLFELPDGMLIETVLMRQHYGLS
                     VCVTTQVGCNIGCTFCASGLIKKQRDLNNGEIVAQIMLVQKYFDERGQDERVSHIVVM
                     GIGEPFDNYNNVLNFFRTINDDKGMAIGARHITVSTSGLAHKIRDFADEGVQVNLAVS
                     LHAPNNELRSSIMKINRAFPIEKLFAAIEYYIETTNRRVTFEYIMLNEVNDSVEQALE
                     LTELLKNIKKLSYANLIPYNPVSEHDQYSRSPKERVLAFYDTLKKKGVNCVVRQEHGT
                     DIDAACGQLRSNTMKRDRQKAVAAVNP"
     gene            complement(25307..25837)
                     /locus_tag="VXE25_000534"
     CDS             complement(25307..25837)
                     /locus_tag="VXE25_000534"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YutD family protein"
                     /protein_id="HEV0771050.1"
                     /translation="MRKEIAPELYNYNKFPGPEFHLHGDKVETEGIAFSLVENIKDAF
                     DVTTFNQRFSEVLTKFDYIVGDWSNEQLRLRGFYKDDRTEEKLEKISRLQDYLLEYCS
                     YGCAYFVLENEAPKRASFDKKMRKTEEETPSRKGKKPTQTKRKSNADKKNRRRQKDQH
                     SQKEDKGQRHFVIRQK"
     gene            complement(25994..26599)
                     /locus_tag="VXE25_000535"
     CDS             complement(25994..26599)
                     /locus_tag="VXE25_000535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="superoxide dismutase"
                     /protein_id="HEV0771051.1"
                     /translation="MAIILPELPYAYDALEPYIDAETMHLHHDKHHQTYVNNANAALE
                     KHPEIGEDLEALLADVESIPADIRQALINNGGGHLNHALFWELMTPEKTAPSAELAAA
                     IDATFGSFEEFQAAFTAAATTRFGSGWAWLVVNKEGKLEVTSTANQDTPISEGKKPIL
                     GLDVWEHAYYVKYRNVRPDYIKAFFSVINWNKVDELYAAAK"
     gene            complement(26772..27809)
                     /locus_tag="VXE25_000536"
     CDS             complement(26772..27809)
                     /locus_tag="VXE25_000536"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001845438.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit delta"
                     /protein_id="HEV0771052.1"
                     /translation="MLAIEESQKLTLSNLPSLSLFTGTDQGQFEVMKSQMLKQIGYDS
                     ADLNFAYFDMKEVVYKDVELELVSLPFFADEKIVILDYFMDITTAKKRFLTDDELKSF
                     EEYLDNPSPTTKLIIFAEGKLDSKRRLVKLLKRDAKVFDAVEVKEQELRQYFQKWSQK
                     QGLQFTNHSFENLLIKSGFQFSEIQKNLLFLQSYKADSVIEEEDIVNAIPKTLQDNIF
                     DLTQFILTKKMDQARDLVRDLTLQGEDEIKLIAVMLGQFRTFTQVKILAESGQTESQI
                     ASSLGSYLGRNPNPYQIKFALRDSRGLSLSFLKQAISYLIETDYQIKTGLYEKGFLFE
                     KALLQIASQVN"
     gene            complement(27843..28778)
                     /locus_tag="VXE25_000537"
     CDS             complement(27843..28778)
                     /locus_tag="VXE25_000537"
                     /EC_number="1.3.98.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519812.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate oxidase"
                     /protein_id="HEV0771053.1"
                     /translation="MVSTKTQIAGFEFDNCLMNAAGVACMTIEELEEVKNSAAGTFVT
                     KTATLDFRQGNPEPRYQDVPLGSINSMGLPNNGLDYYLDYLLDLQEKESNRTLFLSLV
                     GMSPEETHTILKKVQESDFRGLTELNLSCPNVPGKPQIAYDFETTDRILAEVFAYFTK
                     PLGIKLPPYFDIVHFDQAAAIFNKYPLKFVNCVNSIGNGLYIEDESVVIRPKNGFGGI
                     GGEYIKPTALANVHAFYQRLNPQIQIIGTGGVLTGRDAFEHILCGASMVQVGTTLHKE
                     GVSAFDRITNELKAIMVEKGYESLEDFRGKLRYID"
     gene            complement(29331..30521)
                     /locus_tag="VXE25_000538"
     CDS             complement(29331..30521)
                     /locus_tag="VXE25_000538"
                     /EC_number="2.5.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000003937.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine adenosyltransferase"
                     /protein_id="HEV0771054.1"
                     /translation="MSERKLFTSESVSEGHPDKIADQISDAILDAILAKDPEAHVAAE
                     TAVYTGSVHVFGEISTNAYVDINRVVRDTIAEIGYTNTEYGFSAETVGVHPSLVEQSP
                     DIAQGVNEALEVRGNADQDPLDLIGAGDQGLMFGFAVDETEELMPLPIALSHKLVRRL
                     AELRKSGEISYLRPDAKSQVTVEYDENDRPVRVDTVVISTQHDPEATNEQIHQDVIDK
                     VIKEVIPSSYLDDKTKFFINPTGRFVIGGPQGDSGLTGRKIIVDTYGGYSRHGGGAFS
                     GKDATKVDRSASYAARYIAKNIVAAGLAKKAEVQLAYAIGVAQPVSVRIDTFGTGTVA
                     ESQLEKAARQIFDLRPAGIIQMLDLKRPIYRQTSAYGHMGRTDIDLPWERLDKVDALK
                     EAVK"
     gene            complement(30736..32079)
                     /locus_tag="VXE25_000539"
     CDS             complement(30736..32079)
                     /locus_tag="VXE25_000539"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HEV0771055.1"
                     /translation="MSFTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAGRDLVGE
                     SKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSRELATQIYQVARQISAHSDVEVRV
                     VNYVGGTDKARQIEKLASNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLD
                     MGFLETVDKIAGSLPKDLQFMVFSATIPQKLQPFLKKYLSNPVMEKIKTKTVISDTID
                     NWLISTKGHDKNAQIYWLTQLMQPYLAMIFVNTKTRADELHSYLTSQGLKVAKIHGDI
                     APRERKRIMNQVQNLDFEYIVATDLAARGIDIEGVSHVINDAIPQDLSFFVHRVGRTG
                     RNGLPGTAITLYQPSDDSDIRELEKLGIKFSPKMVKDGEFQDTYDRDRRANREKKQDK
                     LDIEMIGLVKKKKKKVKPGYKKKIQWAVDEKRRKTKRAENRARGRAERKAKRQTF"
     gene            complement(32219..33034)
                     /locus_tag="VXE25_000540"
     CDS             complement(32219..33034)
                     /locus_tag="VXE25_000540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398916.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="HEV0771056.1"
                     /translation="MKFLTLNTHSWMEKEAEEKFQILLEDILEKDYDLICFQEINQEM
                     TSSEVEVNDLYQALPAAEPIHQDHYVRLLVEKLLEQGKNYYWTWAYNHIGYDRYHEGV
                     AILSKTPIEAREILVSDVDDPTDYHTRRVALAETVVDGKELAVASVHLSWWDKGFQEE
                     WARFEAVLKKLNKPLLLAGDFNNPAGQEGYQAILASPLGLQDAFEVAQEKSGSYTVPP
                     EIDGWKGNTEPLRIDYVFTTKELAVENLHVVFDGNKSPQVSDHYGLNAILNWK"
     gene            complement(33086..35266)
                     /locus_tag="VXE25_000541"
     CDS             complement(33086..35266)
                     /locus_tag="VXE25_000541"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000974069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HEV0771057.1"
                     /translation="MMKDTFKNVLSFEFWQKFGKALMVVIAVMPAAGLMISIGKSIVM
                     INPTFTPLVITGGILEQIGWGVIGNLHILFALAIGGSWAKERAGGAFAAGLAFILINR
                     ITGTIFGVSGDMLKNPDAMVTTFFGGSIKVADYFISVLEAPALNMGVFVGIISGFVGA
                     TAYNKYYNFRKLPDALSFFNGKRFVPFVVILRSAIAAILLAAFWPVVQTGINNFGIWI
                     ANSQETAPILAPFLYGTLERLLLPFGLHHMLTIPMNYTALGGTYDILTGAAKGTQVFG
                     QDPLWLAWVTDLVNLKGTDASQYQHLLDTVHPARFKVGQMIGSFGILMGVIVAIYRNV
                     DADKKHKYKGMMIATALATFLTGVTEPIEYMFMFIATPMYLVYSLVQGAAFAMADVVN
                     LRMHSFGSIEFLTRTPIAISAGIGMDIVNFVWVTVLFAVIMYFIANFMIQKFNYATPG
                     RNGNYETAEGSEETSSEVKVAAGSQAVNIINLLGGRVNIVDVDACMTRLRVTVKDADK
                     VGNAEQWKAEGAMGLVMKGQGVQAIYGPKADILKSDIQDILDSGEIIPETLPSQMTEA
                     QQNTVHFKDLTEEVYSVADGQVVGLEQVKDPVFAQKMMGDGFAVEPANGNIVSPVSGT
                     VSSIFPTKHAFGIVTEAGLEVLVHIGLDTVSLEGKPFTVHVAEGQKVAAGDLLVTADL
                     DAIRAAGRETSTVVVFTNGDAIKSVKLEKTGSLAAKTAVAKVEL"
     gene            complement(35552..36478)
                     /locus_tag="VXE25_000542"
     CDS             complement(35552..36478)
                     /locus_tag="VXE25_000542"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEV0771058.1"
                     /translation="MISRFFRHLFEALKSLKRNGWMTVAAVSSVMITLTLVAIFASVI
                     FNTAKLATDIENNVRVVVYIRKDVEDNSQTIEKEGQTVTNNDYHKVYDSLKNMSTVKS
                     VTFSSKEEQYEKLTEIMGDNWKIFEGDANPLYDAYIVEANTPNDVKTIAEDAKKIEGV
                     SEVQDGGANTERLFKLASFIRVWGLGIAALLIFIAVFLISNTIRITIISRSREIQIMR
                     LVGAKNSYIRGPFLLEGAFIGLLGAIAPSVLVFIVYQIVYQSVNKSLVGQNLSMISPD
                     LFSPLMIALLFVIGVFIGSLGSGISMRRFLKI"
     gene            complement(36471..37163)
                     /gene="ftsE"
                     /locus_tag="VXE25_000543"
     CDS             complement(36471..37163)
                     /gene="ftsE"
                     /locus_tag="VXE25_000543"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012130521.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division ATP-binding protein FtsE"
                     /protein_id="HEV0771059.1"
                     /translation="MSIIEMRDVVKKYDNGTTALRGVSVSVQPGEFAYIVGPSGAGKS
                     TFIRSLYREVKIDKGSLSVAGFNLVKIKKKDVPLLRRSVGVVFQDYKLLPKKTVYENI
                     AYAMEVIGENRRNIKRRVMEVLDLVGLKHKVRSFPNELSGGEQQRIAIARAIVNNPKV
                     LIADEPTGNLDPDNSWEIMNLLERINLQGTTILMATHNSQIVNTLRHRVIAIENGRVV
                     RDESKGEYGYDD"
     gene            complement(37181..38276)
                     /gene="prfB"
                     /locus_tag="VXE25_000544"
     CDS             complement(join(37181..38203,38205..38276))
                     /gene="prfB"
                     /locus_tag="VXE25_000544"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511312.1"
                     /ribosomal_slippage
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 2"
                     /protein_id="HEV0771060.1"
                     /translation="MDISVIRQKIDANREKLASFRGSLDLEGLEEEIAILENKMTEPD
                     FWNDNIAAQKMSQELNELKNTYNTFHKMEELQDEVEILLDFLAEDESVHDELVAQLAE
                     LDKIMTSYEMTLLLSEPYDHNNAILEIHPGSGGTEAQDWGDMLLRMYTRYGNAKGFKV
                     EVLDYQAGDEAGIKSVTLSFEGPNAYGLLKSEMGVHRLVRISPFDSAKRRHTSFTSVE
                     VMPELDDTIEVEIREDDIKMDTFRSGGAGGQNVNKVSTGVRLTYIPTGIVVQSTVDRT
                     QYGNRDRAMKMLQAKLYQMEQEKKAAEVDSLKGEKKEITWGSQIRSYVFTPYTMVKDH
                     RTSYEVAQVDKVMDGDLDGFIDAYLKWRIS"
     gene            complement(38384..39040)
                     /locus_tag="VXE25_000545"
     CDS             complement(38384..39040)
                     /locus_tag="VXE25_000545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBS domain-containing protein"
                     /protein_id="HEV0771061.1"
                     /translation="MAVKDFMTRKVVYISPDTTVSHAADLMREQELHRLPVIENDQLV
                     GLVTEGTIAQASPSKATSLSIYEMNYLLNKTKVKDVMIRDVVTVSGYASLEDATYLML
                     KNKIGILPVVDNHQVYGVITDRDVFQAFLEIAGYGEEGIRVRFVTEDEVGVLGKIVSL
                     IVEENLNISHTVNIPRKDGKVIIEVQIDGSIDLPALKEKFEANGIQVEEIVRTSAKVL
                     "
     gene            complement(39454..40164)
                     /locus_tag="VXE25_000546"
     CDS             complement(39454..40164)
                     /locus_tag="VXE25_000546"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000062220.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0771062.1"
                     /translation="MSMLKVENLSVHYGMIQAVRDVSFEVNEGEVVSLIGANGAGKTT
                     ILRTLSGLVRPSSGKIEFLGQEIQKMPAQKIVAGGLSQVPEGRHVFPGLTVMENLEMG
                     AFLKKNREENQANLKKVFSRFPRLEERKNQDAATLSGGEQQMLAMGRALMSTPKLLLL
                     DEPSMGLAPIFIQEIFDIIQDIQKQGTTVLLIEQNANKALAISDRGYVLETGKIVLSG
                     TGKELASSEEVRKAYLGS"
     gene            complement(40164..40928)
                     /locus_tag="VXE25_000547"
     CDS             complement(40164..40928)
                     /locus_tag="VXE25_000547"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002913097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0771063.1"
                     /translation="MALLEVKQLTKHFGGLTAVGDVTLELNEGELVGLIGPNGAGKTT
                     LFNLLTGVYEPSEGTVTLDGHLLNGKSPYKIASLGLGRTFQNIRLFKDLTVLDNVLIA
                     FGNHHKQHVFTSFLRLPAFYKSEKELKAKALELLKIFDLDGDAETLAKNLSYGQQRRL
                     EIVRALATEPKILFLDEPAAGMNPQETAELTELIRRIKDEFKITIMLIEHDMNLVMEV
                     TERIYVLEYGRLIAQGTPDEIKTNKRVIEAYLGGEA"
     gene            complement(40928..41884)
                     /locus_tag="VXE25_000548"
     CDS             complement(40928..41884)
                     /locus_tag="VXE25_000548"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid ABC transporter
                     permease"
                     /protein_id="HEV0771064.1"
                     /translation="MKENLKVNILWLLLLLAGYSLISVLVSVGVLNLFYVQILQQIGI
                     NIILAVGLNLIVGFSGQFSLGHAGFMAIGAYAAAIIGSKSPTYGAFFGAMLVGALLSG
                     AVALLVGIPTLRLKGDYLAVATLGVSEIIRIFIINGGSLTNGAAGILGIPNFTTWQMV
                     YFFVVITTIATLNFLRSPIGRSTLSVREDEIAAESVGVNTTKIKIIAFVFGAITASIA
                     GSLQAGFIGSVVPKDYTFINSINVLIIVVFGGLGSITGAIVSAIVLGILNMLLQDVAS
                     VRMIIYALALVLVMIFRPGGLLGTWELSLSRFFKKSKKEEQN"
     gene            complement(41888..42757)
                     /locus_tag="VXE25_000549"
     CDS             complement(41888..42757)
                     /locus_tag="VXE25_000549"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid ABC transporter
                     permease"
                     /protein_id="HEV0771065.1"
                     /translation="MLQQLVNGLILGSVYALLALGYTMVYGIIKLINFAHGDIYMMGA
                     FIGYFLINSFQMNFFVALIVAMLATAILGVVIEFLAYRPLRHSTRIAVLITAIGVSFL
                     LEYGMVYLVGANTRAFPQAIQTVRYDLGPISLTNVQLMILAISLILMILLQVIVQKTK
                     MGKAMRAVSVDSDAAQLMGINVNRTISFTFALGSALAGAAGVLIALYYNSLEPLMGVT
                     PGLKSFVAAVLGGIGIIPGAALGGFVIGLLETFATAFGMSDFRDAIVYGILLLILIVR
                     PAGILGKNVKEKV"
     gene            complement(43025..44185)
                     /locus_tag="VXE25_000550"
     CDS             complement(43025..44185)
                     /locus_tag="VXE25_000550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002206202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HEV0771066.1"
                     /translation="MKKKFALSFVALASVALLAACGEVKSGAVNTAGNSVEEKTIKIG
                     FNFEESGSLAAYGTAEQKGAQLAVDEINAAGGIDGKQIEVVDKDNKSETAEAASVTTN
                     LVTQSKVSAVVGPATSGATAAAVANATKAGVPLISPSATQDGLTKGQDYLFIGTFQDS
                     FQGKIISNYVSEKLNAKKVVLYTDNASDYAKGIAKSFRESYKGEIVADETFVAGDTDF
                     QAALTKMKGKDFDAIVVPGYYNEAGKIVNQARGMGIDKPIVGGDGFNGEEFVQQATAE
                     KASNIYFISGFSTTVEVSAKAKAFLDAYRAKYNEEPSTFAALAYDSVHLVANAAKGAK
                     NSGEIKDNLAKTKDFEGVTGQTSFDADHNTVKTAYMMTMNNGKVEAAEVVKP"
     gene            complement(44286..44534)
                     /locus_tag="VXE25_000551"
     CDS             complement(44286..44534)
                     /locus_tag="VXE25_000551"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000462128.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlbG family protein"
                     /protein_id="HEV0771067.1"
                     /translation="MFEKVNRSGLIIYLYYNRDAKKLQDYGDITYHSKKHRYLQLYVP
                     TQEVEQLVGRLSKEKFIKKVRVCHIQELETPFVGNLYR"
     gene            complement(44613..45203)
                     /gene="clpP"
                     /locus_tag="VXE25_000552"
     CDS             complement(44613..45203)
                     /gene="clpP"
                     /locus_tag="VXE25_000552"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000613477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease proteolytic subunit
                     ClpP"
                     /protein_id="HEV0771068.1"
                     /translation="MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIA
                     QLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMNFIKADVQTIVMGMAASMGTVIA
                     SSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQ
                     SMEKVHADAERDNWMSAQETLEYGFIDEIMANNSLN"
     gene            complement(45377..46006)
                     /gene="upp"
                     /locus_tag="VXE25_000553"
     CDS             complement(45377..46006)
                     /gene="upp"
                     /locus_tag="VXE25_000553"
                     /EC_number="2.4.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002883819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil phosphoribosyltransferase"
                     /protein_id="HEV0771069.1"
                     /translation="MGKIEVINHPLIQHKLSILRRTDTSTKAFRELVDEIAMLMGYEV
                     LRDLPLEDVEIETPITKTVQKQLAGKKLAIVPILRAGIGMVDGLLSLVPAAKVGHIGM
                     YRDEETLQPVEYLVKLPEDIDQRQIFVVDPMLATGGSAILAVDSLKKRGASNIKFVCL
                     VSAPEGVKALQEAHPDVEIFTAALDERLNEHGYIVPGLGDAGDRLFGTK"
     gene            complement(46095..46562)
                     /locus_tag="VXE25_000554"
     CDS             complement(46095..46562)
                     /locus_tag="VXE25_000554"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000138511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine/deoxycytidylate deaminase family
                     protein"
                     /protein_id="HEV0771070.1"
                     /translation="MTEKRLAWDEYFAAQALLIANRSTCKRAKVGAILVKDNKVISTG
                     YNGSVSGTEHCIDHECLVIEGHCVRTLHAEVNAILQGAERGVPKGFTAYVTHFPCLNC
                     TKQLLQVGCKRVVYINQYRMDDYAQYLYQEKGTELTHLPLETVQTALKEADLM"
     gene            complement(46581..47138)
                     /locus_tag="VXE25_000555"
     CDS             complement(46581..47138)
                     /locus_tag="VXE25_000555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000003900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HEV0771071.1"
                     /translation="MSERRISEKSLENLRKSNQESNLLTREAIETALLQLLEKKELTK
                     ISISELVKRAGVSRAAFYRNYDSKEEILESVFKRTVHNIMEQLHHYDLKTDLYLVWVH
                     LFREARKEARVIQLALDYHLEKIFVQAMQEFLEKYHGKSKGVSSYLHSFWSSAIVSVL
                     LKWIKDGMKVPAEKIADLGLPFFKK"
     gene            47263..48108
                     /locus_tag="VXE25_000556"
     CDS             47263..48108
                     /locus_tag="VXE25_000556"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000219932.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HEV0771072.1"
                     /translation="MTWKIIADSGCDYRQLPTPAINTTFVSVPLTIQVADQVFVDDAS
                     LDIDQMMETMYATAEASKSACPSPDDYLRAFEGAKNIFLVTITGTLSGSHNSAQLAKN
                     IYLEDHPDTKIHVIDSLSAGGEVDLLVEKLNDLIDQGLSFEEVVEAITAYQEKTKLLF
                     VLAKVDNLVKNGRLSKLIGTVVGLLNIRMVGKASETGTLELLQKARGSKKSVQAAYDE
                     LVKAGYAGGRIVMAQRNNEKCCQQLSERIRETFPQADIKILPTSGLCSFYAEEGGLLM
                     GYEID"
     gene            48167..49342
                     /locus_tag="VXE25_000557"
     CDS             48167..49342
                     /locus_tag="VXE25_000557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HEV0771073.1"
                     /translation="MKHFDTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLAG
                     TGGGRCNVTNNGSLDNLLAGIPGNGRFLYSVFSQFDNHDIINFFTENGVKLKVEDHGR
                     VFPASDKSRTIIEALEKKITELGGQVATQIEIVSVKKVDDQFVLKSADQTFTCEKLIV
                     TTGGKSYPSTGSTGFGHEIARHFKHTITDLEAAESPLLTDFPHKALQGISLDDVTLSY
                     GKHVITHDLLFTHFGLSGPAALRMSSFVKGGEVLSLDVLPQLSEKDLVTFLEENREKS
                     LKNALKTLLPERLAEFFVQGYPEKVKQLTEKEREQLVQSIKELKIPVTGKMSLAKSFV
                     TKGGVSLKEINPKTLESKLVPGLHFAGEVMDINAHTGGFNITSALCTGWVAGSLHYD"
     gene            49362..49817
                     /locus_tag="VXE25_000558"
     CDS             49362..49817
                     /locus_tag="VXE25_000558"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001081770.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="8-oxo-dGTP diphosphatase"
                     /protein_id="HEV0771074.1"
                     /translation="MNRREAVEFVNMCMIKNGDKVLVQDRVSPDWPGITFPGGHVERG
                     ESFVDAVIREVKEETGLIISKPQLCGIKNWYDDKDYRYVVLFYKTEHFTGELQSSDEG
                     KVWWEDFENLSHLKLATDDMSDMLRVFLEEDLSEFFYYKNGDDWLYDLK"
     gene            complement(49837..50586)
                     /locus_tag="VXE25_000559"
     CDS             complement(49837..50586)
                     /locus_tag="VXE25_000559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000274794.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HEV0771075.1"
                     /translation="MYHIKEAAQLSGISVKTLHHYDKIGLLVPLKSENGYRTYSQEDL
                     ERLQVILYYKYLGFSLEKIAELLKEERTDLLPHLTRQLDYLTRERQHLDTLISTLQKT
                     IQEQKGERKMTIEEKFTGFSYQDNQKYHQEAVEKYGQEVMGQALERQKGHEDEATAAF
                     NQVFQTLAQNLQVGLPATATENQEQAAKLLQAIRTYGFDCSIEVFGHIGKGYVYNPEF
                     KENIDKFGSGTAQYTSDAIAAYVQTNAEKIG"
     gene            50814..52149
                     /locus_tag="VXE25_000560"
                     /pseudo
     CDS             50814..52149
                     /locus_tag="VXE25_000560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466604.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="sodium-dependent transporter"
     gene            complement(52189..53133)
                     /gene="manA"
                     /locus_tag="VXE25_000561"
     CDS             complement(52189..53133)
                     /gene="manA"
                     /locus_tag="VXE25_000561"
                     /EC_number="5.3.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-6-phosphate isomerase, class I"
                     /protein_id="HEV0771076.1"
                     /translation="MSEPLFLQSVMQEKIWGGTKLRDEFGYDIPSEKVGEYWAISAHL
                     NGVSKVANGRYEGTDLATLYAEHRELFGNRPEPVFPLLTKILDANDWLSVQVHPDDAY
                     GLEHEGELGKTECWYIIAADEGSEIIYGHNAKSKEELRQQIEDKNWDALLTKVPVKAG
                     DFFYVPSGTMHAIGAGILILETQQSSDTTYRVYDFDRKDDKGNLRELHLEKSIDVLNI
                     GEPANSRPVTIKADDLRSTLLVSNDFFAVYKWEITGKVNFEKTADYSLLSVLAGQGQL
                     TVDGKNYPIQKGRHFILPSDVESWTLEGQDLELIVSHP"
     gene            complement(53254..53550)
                     /locus_tag="VXE25_000562"
     CDS             complement(53254..53550)
                     /locus_tag="VXE25_000562"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000380709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="family 1 glycosylhydrolase"
                     /protein_id="HEV0771077.1"
                     /translation="MDTPDENGYVADDYRITYLEAHIKAMRDAIYQDGVDLLGYTTWS
                     CIDPVSAGTGEMNKRYGFIYVDRDNVGNGTLKRSKKKSFYWYKDVIDSNGVSIE"
BASE COUNT        15625 a        11772 c         9833 g        16360 t
ORIGIN      
        1 tttacatgag atagctgagt tttcttttta ttttaggctt atttatgcat ttccgtattg
       61 aagaacaact gcttcgactg cagctttttc acggctaatc aagtcaacac gcgctgcaat
      121 ttccttgatt cccataccga tgttacggct aagagcaagg tcagaaagtt gcggttcaaa
      181 gaactccttg tattccgcca agcgttgctg agtcttaaat acatgagcag gaaggataac
      241 aaagctatca aagctcatat ctcctccaag ggctgcctta atccaagccc agttttcacg
      301 cgcccaagac caagctgttt tctgagttgc ttgatgagct aggaattggt aataccaagc
      361 agacaagtcc tgtggtttga ccacaaattt gtccttccaa gaagtaatca agttttggat
      421 attatccgca tctgtactgt atgcaagagc tgctgccaac tggcgtttaa agacagcatc
      481 tgttgcgtga gtataagtat caagataaag tgctaacaag tctttagtct catgatgttt
      541 catctcatta atcagaactt gtgaacgaat agctgctggg agtcctgcaa gattctcctt
      601 gtgtgttgcg aagatttggc tagcgacttg actagcttct gcatcatttg agcgaatcat
      661 catcgaaaca gccagctgac gaaccaattc atcctcatct gattctccgt ctttagcttc
      721 aaaaccaaga cggtcatagt tatgacgagc caatttagca accagtcctt tgaaggctgt
      781 ttcagcatcc gttccttcat caataaagcg ctcaagggct gaaatcactt gagaaacagc
      841 tgaaaccacc agataagact cttccttagc aagtttatca agaactggaa gcaagtctgc
      901 ataagaaatg tgccctgcct cagccaacaa acgacgttct tgaacaattt gcagtttgct
      961 tgtgttatca agtgtctcta gctcagcaag aacagctgct aacaagtctc cttgatagtc
     1021 ggtaatatag tgggcagtat tttcagtgtt gagacgaaga gctccttcat tttcagcaag
     1081 aagagctgcg tagccaggga tttcgatact ttcagtttcg agtgtatcag gcaagccttt
     1141 ccagttgcta ttgaggggca ccacccagag acggttcttg tcttcgttct caccgatgaa
     1201 gaattgtttt tgtgaaatct tcaagacatc attttcaact ttgacagtaa gaactgggta
     1261 accaggctgt tccaaccaag aatccatgaa ggctgcgaca tcacgtcctg acgcttgacc
     1321 aagggcatcc caaagatcac taccaatggt gttgctgtat tggtgttttt caaagtaggc
     1381 atgcaaacct ttagcaaaat cagcatctcc tagccaacgg cgaagcatgt gcatgagacg
     1441 gcttcctttg gcatagacga tagcgccgtc aaagagtgta ttgatttcat ctggatgttt
     1501 aacttcgacg tggacagact gaacgccatc agtagcgtca cgttcaagag caagaggtac
     1561 tccacctgtt tggaaatctt caaagatatt ccagcttggt tcgatggtat ccacacagac
     1621 gtattccatc atattagcga aactttcatt gagccaaagg tcatcccacc atttcatagt
     1681 cacgaggttc ccaaaccatt ggtgagccaa ttcatgggcc acaacaaggg caacttgttg
     1741 acggctagca aatgtagagt tctcatcgac aaccaagtaa acttcacggt aagtcacaag
     1801 accccagttt tccatagcac cagctgagaa gtcaggaagg gcgatgtgga gagattgagg
     1861 aattgggtac ttaactccat agtaatcttc gtaaaactcg atagagcgaa cagcgatatc
     1921 cagtgagaaa tcaagatttg aaagtggatg tgctttggtt gagtagacac ctaccagggt
     1981 accattttta gttttagcgg tcaccccttg caaatcacca gcaacaaagg ccaacaagta
     2041 agaagacatg cgaggtgttg tctcaaactt ccagatacct gtttccttac ggttttcaac
     2101 atcgatttct ggcatgtttg acaaggccaa ttcaccttct gcttggtcaa agcgaagaga
     2161 gaggtcaaaa gttgctttgg cttcaggctc atccacacat gggaaagctt cgcgcgcaaa
     2221 atggctctcg aactgagtag acaagacctc cttcttgact ccatcaactg tataataaga
     2281 agggtaaatc cctgtcatgt tgtctgtaat tttaccagaa aaggcaagaa ccaattcaac
     2341 ttgaccagcc tcagccaatt cgatatgaag ggcttcattg tcatggtcaa ctgtaaatgg
     2401 acgagcttga cctgcaactt ctacagaggt gatttccaag tctttttggt ggagggagat
     2461 gcggtcactc tgtgcttgac cagtgatggt cactttccca gaaaaagtct tggtctcacg
     2521 actcaaatct aaaaataaat cataatgttc aggaacaaat tgcttaataa aatgttcaac
     2581 tgcttgcata gttttctcct attctaagtt taagagctgc tgctcttctt caaacaaact
     2641 tattatatca tattttgctt gagaaaaaag gattggacag cgatttccaa aactttcttc
     2701 cttctaatag tctacagtgg gtagaccttg cgaaattctt ctaaaacaac cttgctttca
     2761 ggtgtaaaag tcagccctac ttcacccaaa cagtctgtga aaaagtcctc atgaatctgg
     2821 cgccaatagg caagtgattt gtctccctca ccttccttaa aggcatgttg cgcagaaact
     2881 tgattgaaga gttcaacaga aacctttgta atttcgacaa tgcagacaga ctgattttga
     2941 ctatctaaaa tgacatcgaa ggtccctact tggggaagtg gttcgtcttc tagtacatag
     3001 aggtcatagg ctgatgctgt tgctgtcttt tctcctttaa acaccaaatc cgctaaaagg
     3061 tctggttcaa ctccaaaagc ccaagcatcg atttcatctc cgatcaaagg attgatttgc
     3121 ttgtatttat tccacatttc ttgcggtatc atgggtactc ctttgtaatt ttttactttc
     3181 ttcttttatg tgtttaagat gatctggatg gtcaatctct aaatcaaaaa tctctggaat
     3241 agaactgtag tggataatgc acttgatacc caactgattc attttttgta tgaaagaagt
     3301 attcagatag cctgctacag caaaattaat cttgttcttt cttgctttat cctgcatatc
     3361 tcttagcata tctaacatta ttggactttc cagatcatgc cattgactgt ttctcatagt
     3421 cgcaaaaaca aaggaagtca aatcatttat tccaactaca atctttgaaa tgcccgtttc
     3481 cagtatacta gataagtcaa aatacgctga cggtaattca atcatcgttc cgactttccc
     3541 agtaaagcca tactgacgca atactgtaat agcttgtttt aattggtcgg catcattgac
     3601 aaaaggaaag ataagagaca gattggggtt ggtttgataa acttctgtaa cgacatgtgc
     3661 ttcagcctga aattcatcca aacacgccag taaacgcctg gttcctctat agccaaacaa
     3721 gggatgccct tcgtcaaaaa actctttagt ccccactaaa caattggctt ctgtattcgt
     3781 taattcagta aaacaatacc aaacttcttc atctgagtac agggagcaga tagtctctag
     3841 ataatctttt acaaattgct gacaacttgc taatatgatg ttttgattaa gctctctcaa
     3901 caaatattcc ccacgaatca tgccgacgtg gtgaaatagt tgaggataaa ttttttcaag
     3961 aattttttcg ccactaaggg caagttgatt tctcatcatt caccttccaa ttcatgtaag
     4021 aagtcttgtc cagttctgga aatcctaata attcagactt aaccttcaag actaatggcg
     4081 atgcattttc ttctgtaatc tcttgaatat ccatccaaat atatccaagt gaatcattcg
     4141 caccatcaga cacagcttcc gaagtcgtaa cttgaggtgc actctcattc atttcaacat
     4201 catacaaggc catgacatgg tgaaccataa aatttgttaa ctcttctctg acgaaaacat
     4261 cgtagattcg aggattagag tagcttctaa cagtaaatcc cgtctcttcc ataacttctc
     4321 tagtcagcgt ttccgtcagt ccttcaccaa gttgctgact gcctccaggt agatcatacc
     4381 gatgttgata agggcctctc gctttttcaa tgcagagtaa cttcccattt tctaagcaaa
     4441 cagcgtagac tccaaagtgt tttttgattt ccatccaact cctcctactt caaagaccag
     4501 ccaccatcta ttgtcaagat ttgtccttgc atggcgctcg cttttccact tgctaaaaaa
     4561 agactaagct ctgctatttc ctctggctca atccagcgct tgattggggt ttcactagcc
     4621 acccagtcag ccaaaccacc tggttcaaaa tccgcagcgg tcatagctgt cttgactgct
     4681 cctggagcga tcccaaagac ctgaatccca gcttcagcat agtctagagc caactgcttg
     4741 gtgaagccag ccaaggcatg cttggatgaa gtataggcgt gaccacctcc acctgctagg
     4801 ctagaagcaa tggaacacat attgatgatg attccctttt tattttccag catttgtgtc
     4861 aaataatacc gagtcaactc tactggaata atgtagttga tttcaaaaat ctcttgaatg
     4921 tcctgcgccg tttgttccaa cagtggtttg taatcatcca aaactccggc agtattacac
     4981 aaaacatcca cctgagggca ccagtcaaaa ataggttcca agtccaaggt caaatctctc
     5041 tgtaaaaagt gaaaatcacc ctctaagagt ggcttttcac cttggtcaac tccataaact
     5101 tgatagccct tctctaaaaa gaggcgagct tgagccaatc cgatccctga actcactcct
     5161 gtaatgagta cacgtttagt catgcacttc tacccaatcc gttgccaaaa catcacaagc
     5221 tgtcgggctc cacatggaaa aaccttctcc ttctccagac acgttgatta ggaaataagg
     5281 tgtcatttca agtgcaagcc cattttgctc gatggtatca aagagttgga catagttttc
     5341 cgcacctccc caaccagttc gtacatattt tctcttagcc tttaacccag gcaggatctc
     5401 ttcaaatgtc atgtttttct cctttaattc tacattcttc atttaattat aacaaaaaaa
     5461 ccgctttaaa acggcttttt gactgtgatt tatttacatc ttcttctact tacggcaaat
     5521 tattccctgc agcaagataa atttcatacc attcttttct tgttaagcta aagtttgccg
     5581 cttggctaac ttctctcaag tgcttaggat ttgtggtacc tacaactgcc tgcatttttg
     5641 ctggataacg caatatccaa gaaatggcaa tagttgaaga ggttactcca tatttaatag
     5701 ctaaacgatc aagtacttga tttaaagctt gaaatttctc atttccaaca aaattccctt
     5761 taaaataccc gaattgtaag acagaccatg cttgaatgac cacatcgtgt aatttgcaat
     5821 attcaaaaat gctgccatct cgcatagctg cttgactatc ttccatatta acatgaaaag
     5881 ctgattcaaa tcctggagta aaagccgcac tcaattgtag ctgattaaca gctaacggct
     5941 gcttgacatc ttttttaagc aactccatca tcataggatt ttgattagaa actccaaaat
     6001 ctcgaacttt accttgttta taaaggagat caaaggcttc tgctacttgg tcagattcca
     6061 tcaaagcatc tggtcgatga aggagcaagc tatctagatg atcaatcttc aatctttgca
     6121 aaataccgtc tactgatttt ataatatagt ccttagaaaa atcaaaatag gtaaattctt
     6181 caatgcgaat gccacatttg gactgaatcc acatcttttc tcttaaatct ggacgatttt
     6241 ttaggacaag acctaacagt tcttcacaac gaccacgacc ataaatatca gccaagtcga
     6301 aggcattgat tccaacagaa agtgctgttt ctacaagctc ttcaacttct tttacagact
     6361 tatcttttat tctcatcatt ccgagaacaa tttctgataa ttctttgtca tcttgaccaa
     6421 gagttatgta tctcatcaaa tttttctcct ttaatttcta acattcttcc cttcattata
     6481 acaaaaaacc gctttgcaac ggctttttga ctatacttca ctccatttta tcttcttaaa
     6541 cccacggaac aagacaaaga ttccaataaa gaggacagct aaaggaataa cttttgtaag
     6601 gaaaacattt gaaattccca tccactcata ataacggagc agagaaccca ccacaagatg
     6661 ggcaataatc atactgacaa atggacgaaa gaccgcttct ttccaattcc aaataccgat
     6721 aactagcgaa atcgtaaaga cagacaaact atcccaggga gccggaatat aaaaggctcc
     6781 ttcttgtatg aagcttgcca ttcctacata tcctaaaaca actagaagaa ctatagtccc
     6841 aacaacaatg taagtgccaa ttttcatttt aggagaatct tggactaaac ttcttcgtaa
     6901 aattgtgacc acaagtccaa atccaatcag aaaaataaga agttgcccta aaaatgtgag
     6961 caaattgact gttaagagag gacctttaga aaaatcactt agtagttgat aataacgtaa
     7021 taccgccagg acaagaattg gcgtcaaaag ggactctttg atagaactgc gaggtgctcc
     7081 cttgagaatc tctttcatta tttttttagg attcttacct agataatcct ctgcactcat
     7141 gccatctcgt tctgcttctg agaaatctag catcatcaaa tagatctgct ctctgagata
     7201 gtcttcatca tagagaaatc caacaagatt aaaactttcc cacaactcct caaaatactt
     7261 ttgattctcc tcagaaaact catgtagcaa agcgcttgtt tcttcgtaat acttcatttt
     7321 cttcatggtt taacccccat tcttaatccc ttctactttt tgactcaaat cgtcccattg
     7381 ttgccaaaag actgagacac gctcttctcc ttctttcatt aatgaaaaat acttccgatc
     7441 tggaccatct ggcgacgggc gcatgtcgcc tcttatccat tgattttttt ctaacttttg
     7501 caacaaagga taaatagttc ctggaacgat agtatcaaat ccagcctctc gcaaagtctg
     7561 aaccaactca taaccatacc gctctttttg accaatcata tccaagacac aaccttcaag
     7621 aacacctttt aatagctgag tttctttcat cacttctccc ttctaatcta ttttgtaata
     7681 cctactagta acttcaccta tagtatatca cttctacact agtttgtaaa gcataatagt
     7741 taatactctt cgaaaatctc ttcaaaccac gtcatcgtcg ccctaccgta tgtatggtta
     7801 ctgacttcgt cagtttcatc tacaacctca aaaacatgtt ttgagctgac ttcgtcagtt
     7861 tcatctacaa cctcaaaaac atgttttgag ctgacttcgt cagtttcatc tacaacctca
     7921 aaacagtgtt ttgagctgac ttcgtcagtt ctatctacaa cctcaaaaca gtgttttgag
     7981 ctgacttcgt cagttctatc tacaacctca aaacagtgtt ttgagctgac ttcgtcagtt
     8041 ctatctacaa cctcaaaaca gtgttttgag caacctgcgg ctagcttcct agtttgctct
     8101 ttgattttca ttgagtataa ataaaaaaac agaactagcc tgaactagtc ctgtctactt
     8161 ttacccaatc acacttccat ttggtacagc tggatcaact gtgagaaggg ttaatttgcc
     8221 atcatgttca gctgagagaa tcataccctg gctgacatat tttttcatca ttttacgtgg
     8281 tttgaggtta gcaacgattt gaactttctt gccgaccaat tcttgttcat ttggatagta
     8341 ttttgcaatt cctgaaagaa tctgacgatc ttctccatca ccagcatcca agcggaattg
     8401 aagcaactta tctgaaactt ctactttaga cacttctttg acttctgcga cacggatttc
     8461 aaccttgtca aagtcttcaa acttgatttc atccttgttt agtttgagct caacttcgtc
     8521 cggattccat tctttttcga ctgctggttt attgccttcc atttgttcct tgatataggc
     8581 gatttcttct tccatattta gacgtggaaa gataggtgtt cctttggcaa ctacagtcac
     8641 atctgctggg aagtcagcca aactcaagtt ttcaagacta gaaacttctt ccaaaccaag
     8701 ttgagtcaaa actgcacgac tagtttccat cataaatggt tcaatcaagt gagcaactac
     8761 acgaatgctg gctgccaagt ggctcatgac acttgccaat tggtcacgaa gagcttcatc
     8821 cttggccaag acccatggtg cggtctcatc gatgtattta ttggtacgag agatcagagt
     8881 ccagactgct tcaagcgcac gtggatagtc aactgcttcc atgtgtgtat ggaagtctgc
     8941 gattgattgt tctgcaacct cagcaagaac atgatcaaat tcagtcacac cttctacata
     9001 ggcagggatt tgtccatcaa agtacttatt aatcatggaa accgtacggt taaggaggtt
     9061 cccaaggtca ttagccaatt catagttgat acggccgaca tagtcttcag gagtaaaggt
     9121 tccgtctgaa ccaactggaa ggttacgcat gaggtagtaa cgaagtggat ctagtccata
     9181 acgctctacc aacatttcag ggtaaacgac attccctttt gacttagaca tttttccgtc
     9241 tttcatgaca aaccaaccat gggcaatcaa acgatcaggt aatttaacat ccaacatcat
     9301 aagaaggatt ggccagtaga tagagtggaa gcgaaggata tcttttccta ccatatggaa
     9361 gactgttcca ttccagaact tgtcaaagtt accatgttcg tcttgagcgt agccaagagc
     9421 tgtcgcatag ttaagaaggg catcaatcca aacgtagaca acgtgttttg gatttgatgg
     9481 gacaggcact ccccatgtaa aggttgtacg agataccgcc aaatcttcca agcctggctc
     9541 gatgaagttg cgtagcattt cattaaggcg accatctggc gtgataaatt caggatgagc
     9601 tttgaaaaat tcgaccaaac ggtcttggta tttgctaagg cgaaggaagt atgattcttc
     9661 agaaacccat tcaacctcat gacctgatgg agcaatacca ccagtcacat ttccagcttc
     9721 atcacggaaa acttctgcca gctggctttc tgtaaagaat tcttcgtctg atactgaata
     9781 ccaaccagag tattcaccca agtagatatc atcttgagca agtaagcgtt caaagacctg
     9841 tgcgacaact ttttcatggt agtcatcagt tgtacggata aatttatcgt atgagatatc
     9901 tagtaattgc cagagttctt taactccaac cgccattcta tcaacataga cttgaggtgt
     9961 aataccagct tcttccgctt tctgctggat tttctgacca tgttcatcaa gacctgtcag
    10021 ataaaataca tcgtagccca tcaggcgttt gtaacgtgct aggacatcac atgcgatagt
    10081 tgtgtaggca gaaccgatat gaagtttccc agatggatag taaatcggcg ttgtaatata
    10141 aaaattcttt tcagacataa tttttccttt ccaggcaaat gaaacctgtt tttctaacac
    10201 ttcattatat cacattttta atgaatttcg atagggaaat ccatacaaaa acaagataga
    10261 cgagtgtcca tcttgttgat ctcattcata acgaagggct tcaattggat caagtttcga
    10321 tgccttgttg gctggcaaga ctccaaaaat cataccaaca ctagccgaaa ctgcaagact
    10381 aaatagggca actgggattg atactccaac ttctatacct tctattaaac cttgcagtaa
    10441 caaacctgct aaggcagtta aaccacttgc aattgtcaag ccaattaagc cacctaacaa
    10501 ggtcaaaatc atggattcaa tcaaaaactg aattaaaata ttggcacgtg ttgcacccaa
    10561 agccttacga agaccaatct cacgagtgcg ctctgtcacc gaaaccagca tgatgttcat
    10621 gacaccagtt cctccaacaa agagagaaat ccctgcgatg gaactaataa tcgtcgtcat
    10681 aaaactaaac gattgttgaa tttctgcaaa tacaacggac tcatctgcca cctggtattc
    10741 tccctgttgt aagcctgcaa gctctgtcat ttttcgtgcc agttctggac ccagagttgg
    10801 ggttaaactg gtatcattca ctcgaaagac aatactagct atttcatcta tattaaaatt
    10861 cgcagcaagg gagatattgg tagtaatagg caagccacca aacccatata tttttgacct
    10921 tttagcctcc ggactagtat aaaccccaat gacccggtaa ctaaatccat tgacttctac
    10981 aaccttgtta atagcctctt gaggagattc aaataaacta atggacaatt cctcatctag
    11041 caaaataaca cttgcaaact ctttgaaatc ttgctctctc agactacgac ctgcaataat
    11101 ttcattctta acagcatcca tgtaagttct gtttccacct gtcaaattag cattctcaac
    11161 ctttttatct tgataggtca agatggcatt cgttgaattg gttacatagt aactatccac
    11221 tcccttcagt ttagctgcct cttgaaccca ggattcttgc ggttttggcg gttcaacagg
    11281 aacttcctct tcctttccag aaaccgtaaa agctgattgt ttctgagtaa aagacccatc
    11341 tttacttttt ttaggagaga aaaagacgct aatatttttc tgagatttag tcatatcttt
    11401 attgacttga cgagataggg aatcacccaa agccataatc acaacaactg atgaaacacc
    11461 gataataatc ccaatcatag taagcaaaga acgcatcttg tgagccatga tagatgaaaa
    11521 ggcaaatttc agattctgca tcttagtttt cctcctttcc taactgagca ctgtcagacg
    11581 aaatgacccc atcccgaatg acaatctgac gtttggcata ggcagcaatc tcaggctcat
    11641 gcgttaccat gataatggtt tttccttctt tattcaaatc aaccaataat tgcataattt
    11701 ggttacctgt tttggtatcc aaggctcctg tcggttcatc cgctaggata atagaaggat
    11761 tgtttaccaa ggcacgcgca atggctacac gttgcttttg accaccagat aattctgaag
    11821 gtaaatggtg actacgttct gtcaattcaa ccttgtctaa atattcctca gccaacttgc
    11881 gacgttttga agacgaaact cctgcgtaaa tcaagggcaa ttctacattt tgcagagcat
    11941 tgagcttcga tagaagaaag aactgctgaa agacaaaacc gatttgttgg ttacggacct
    12001 tagccagttg tttttcacca agcccagcca cttcttgacc ttcaagataa tattctccac
    12061 tggttggtgt atccaacatg ccaatcgtat tcatcagagt ggacttacca gacccagatg
    12121 gtcccatgat ggctacaaat tcaccctcat tcacttctag attgatattt ttgagaacct
    12181 gcagttcttg gtcaccatta cggtagcttc tgaagatatt ttttagacta attagttgct
    12241 tcatcagcct tcacctcttt tccttcttcc aaggaagatg ttggattact gatgacctta
    12301 gcaccatttg tcaaaccaga agtgatttct tgattttctg cgtcagcatt tcccaatgaa
    12361 acctcaactt ttttagcctt ttgttgttca tccacaatcc agacataatt tttactatca
    12421 tccattacta gactgctaac aggaacaaga atagccttag ttttgctttt aacctcaatg
    12481 ttgacagaaa aaccttgttt caaatcacca acctcgcctg tcacatcaat agtataaggg
    12541 tatttagaac ctgtattatt cccggctgct ggactagctg cttcaccatt gtttttagga
    12601 tagtcagaaa tatagcttaa tttcccagtc cattttttat caggatacac tttagaagta
    12661 aagcttactt cttgacctac agaaaggttg gctagattgt actcagacaa ttctcccttg
    12721 acttgtaaat tttcattgct gacaatatga accataactt gactcgcccc tgttggagat
    12781 ttagaaacat tgctattgac ttcgaccaca gttccctcta gggtactgag aacagttgtt
    12841 gcatccaatt gactttgagc cttgcttaat tgcgctgcag catctgcacg cgcatcacgg
    12901 gcatcaccca attgagcatc aatagaagca acagaatttc cagccactgg agttgggctt
    12961 tgcaccgttg catcttctcc tcctactggc gctggtaact gtggagcctg agctgaagcg
    13021 gcttcatttc gtgcttgatt gagttcattg atatgacgat ctgccttagc tactgctcga
    13081 ctagctgaat cataggccgc ctgcgcttct gaactactgt acttgactaa agcctgccct
    13141 tcgctgacct tatcgcccac agaaacaagg atttcatcta aatcaccctt actagcatca
    13201 aaataaacat attgttcatt ttttgctgtt actgtccctg acaataaaac agaggatgcc
    13261 acgcttcctt ccttggcaac aacaagatga gtaggctcat cttttacagc agtctgagaa
    13321 ggttgtctaa agagtaaaat ccccccggca cccaatacaa ctacactcgc agcaccgatt
    13381 gctgcataca gttgccactt tttagcttta ccattctttt tcttcataat gaaactcctt
    13441 ttctttttta caatactttg ctattatacc aaatttccct ccagcaaaca atgcagttca
    13501 gatggaaata atggcagttc aggattaaac aatcgttcgg aattttgctt ttctattgta
    13561 ctagatatat aatacactat tttgacttat ttggcaagct tttttgcaat tttttgtgcg
    13621 tagcagattt ttgcaatcaa atcaaaaaaa gaataaaata taactatcaa aaaagacgct
    13681 ctactattta aaagattaca aaggagtttt caatgagaga atatgatatc attgctatcg
    13741 gtggaggtag cggaggaatc gctaccatga accgtgctgg tgaacatgga gtcaaagcag
    13801 ccgttattga ggaaaagaaa ttaggtggaa cctgtgtcaa cgtcggttgt gttcctaaaa
    13861 aaatcatgtg gtacggggcg caagtcgctg agactttcca tcaatttgga gaagactacg
    13921 gctttaagac tactgatctt aactttgact ttgcaaccct acgtcgcaat cgtgaagcct
    13981 acattgatcg cgctcgttct tcttatgatg gtagttttaa acgcaacggt gtagacttga
    14041 ttgaaggtca tgctgaattt gtagattctc atactgtaag cgtaaatggt gaactgattc
    14101 gtgctaaaca tatcgtgatt gctacaggtg cccatccaag tattcctaat attcctggtg
    14161 ctgagctagg tggctcttct gatgatgtat ttgcctggga agaacttcca gagtcagttg
    14221 ccattctagg cgctggttat atcgccgttg aattagctgg cgtactccac acttttggtg
    14281 tcaagacaga tctctttgtt cgccgcgatc gtcctttacg tggttttgat tcctacatcg
    14341 ttgaaggttt ggtcaaggaa atggaaagaa caaacttacc acttcacact cacaaagtcc
    14401 ctgtcaagtt agaaaaaact actgacggca ttaccattca tttcgaagat ggtactagtc
    14461 acacagctag ccaagttatc tgggctacag gtcgccgtcc aaacgttaag ggcttgcaac
    14521 ttgaaaaagc tggagtgact ctgaacgaac gtggctttat acaagtggat gaataccaaa
    14581 ataccgtcgt tgagggaatc tatgctctag gtgatgtaac aggcgagaaa gaactgactc
    14641 cagttgcaat caaggctggg cgtaccctat cagaacgtct ctttaacgga aaaacaactg
    14701 caaaaatgga ctactcaact attccaactg ttgtcttttc acaccctgct atcggaactg
    14761 ttggtttgac agaagaacaa gctattaaag aatacggtca agaccaaatc aaggtttaca
    14821 aatcaagctt tacttctatg tactctgctt gcacttgcaa ccgtcaagaa actcgtttca
    14881 aattgatcac agctggttca gaagaaaaag ttgtcggact tcacggaatt ggctacggcg
    14941 ttgatgaaat gattcaagga tttgctgttg ctatcaaaat gggagcaacc aaggctgact
    15001 ttgacgcaac tgtagcgatt cacccaactt catctgaaga atttgtaacc atgcgttaat
    15061 cgaaacaaaa gaagctgata taaatatgtc tgcttctttt ttaatgattt tcgaatcaac
    15121 aaaaaaatta tccaacttga ctagtcacga aaatcggctg ttacagtttt tgttaccttg
    15181 tttttaaaaa atggttgaca tcgactccta tatgagtata atagttaata tacattagaa
    15241 aagaggttaa ctattttgaa aaaagctcac gtttatgcta tccctgctat tggggctgct
    15301 ctcattgctg ttttggcaca aatcagtctt ccaattggac ctgttccctt cactctgcaa
    15361 aactttgcaa tcggcttgat tgctactgtc tttagaccga gagaggctgt actttctgct
    15421 ggactctatc ttcttctagg tgctatcggt cttcctgtct ttgcaggagg tggagctggt
    15481 tttcaggctt tagttggccc tactgcaggc tatctttggt tttatctcgt ttactctgga
    15541 cttacttcct ctctaaccaa cagcaagagt ggtgttgtta agatttttct tgcaaacctc
    15601 ttgggtgatg cccttgtctt tgtcggcggg attctcagct tgcatttcct agctggaatg
    15661 gcatttgaaa aagctcttgt tgtgggggtt cttcccttta tcattccaga ccttggcaaa
    15721 cttctggcta ttagttttat tagccgtccc ctacttcaac gccttaaaaa tcaggcttac
    15781 tttactaact aaaaaaggat accgagttat catgactcaa tatccttttt ttattttgaa
    15841 aacttatact caatgaaaat caaagagcaa actaggaagc tagccgcagg ctgctcaaaa
    15901 cactgttttg aggttgtgga tgaaactgac gaagtcagta accatacata cggcaaggca
    15961 aagctgatgc ggtttgaaga gattttcgaa gagtattagt tgcctttaaa ggcatccacc
    16021 atcgtttgaa attcttcatt tgagagagta atccctttgc ccattttagt atggtctgga
    16081 ctccaagcac gaatatcaaa ctttgcaggg gcaccattaa agctcacacg gttaatttcc
    16141 ttggtccaac ctttttcgtt ttcagaaaga gtcaacaagt gctcttcgat ttcaaatgta
    16201 aattctgcca ttttcttctc cttttttagt ttcattagtt tattcgtaaa atcttgtaga
    16261 ttttaggaaa attttatata atattgatat aaaagaaggg aggccaatat gagacataaa
    16321 ttccagcaag ttctaaataa aatacatgat tttttaaatg gatatgacca acctgaccag
    16381 actgaaacca actcccttac agccactatt gaagaggcta tccagaaaca aaccgctgtt
    16441 caccttatct tatctgagac aagctttaca ggtgacatca tcaaatatga tcagcaaggc
    16501 cagcaaatta tcgtgaaaaa tttttccaaa aatgtgagcc ggattatccg tataagcgat
    16561 attcaacgcc tgcgatttgt cccctcaact gtccaaacag cccaaaaaaa tagatttaag
    16621 aaagagtgag atgtagttgc ttcatcccac tctttttctt agcgaatttg ttcaaaatgt
    16681 aaatgaactg cgatatgatc tccataacca cttctttcca agtcacgttg taaacgatag
    16741 gaaatatagt gttctgcaat ggtaatgtaa cctgcgccca ataaacgatg ttcaaccata
    16801 gattgaatca tactgatagt cgcacgttcc accttggctt cttgtaaatc caaaactacc
    16861 ttcttagtga cttgagcaag attttgacgc aaatcatctg tcaaaacata aacagtttgg
    16921 gctgccttca agatggcttg gtaaatctta tctggattaa attcagcaat ttcgccatta
    16981 cgtttgatta cttgcatagg tttctccttt attctttgtt ttctttgatt tctgccagca
    17041 ttttttcttc ttctactgtc agttgataat gttcaagtaa atctggtctg cgctcgtagg
    17101 ttttctttaa actctcgtac aatcgccact gacgaatctt ttcatggtgg ccactcatca
    17161 atacatctgg cacgaccatg cctcgataat catagggacg tgtgtactga ggatattcta
    17221 aaagacctga agaaaaacta tcatcttggt ggctagactc cttgccaatc acttctggaa
    17281 tcaggcgaac tgtagcatca atcatggtca tagctgccaa ttctccacca gtgaggacat
    17341 agtcgcctag ggaaatctca tctgttacca aggtcttaat gcgctcatca taaccctcat
    17401 agtgcccaca gataaagatt agctcttcct cttgagccaa atcttcagca taagcctgat
    17461 caaactgctt tccagcagga tcgaggagaa taacgcgcgg atttttcttt tcaatagcat
    17521 caaaggaatc gaaaataggt tgtactctga gcaacatgcc ctgaccgcct ccgtagggct
    17581 catcatctac atgacgggcc ttttcagcat tttctcgaaa attatgatac tggatatcca
    17641 agagcccttt ttctcgagcc tttccaacga ttgagtgctc cagtggagaa aacatctctg
    17701 gaaagagggt taaaatatca atcttcatcg tctaaccctt ctaagatttc cacatcgacc
    17761 cgtttatttg gaatatcaac attgagaacc actggtggga tataaggtaa aagcaaatca
    17821 cgtttgcctt ttcgtttgac cacccagaca tcattagcac ctggttgcag gatttccttg
    17881 atggttccaa ccaagctatc accctcatag acttccaaac cgataatctc gtgatagtaa
    17941 aattcaccat cgtctaggtc attcaaatct tcctcagcga ccttgagact gtatcccttg
    18001 tacttttcga tagtattgat atggtacata tctttgaatt taataatgtc aaagttcttc
    18061 tgtttacggt ggctagcgat ggtcactgtt tggacaaact gatctttttc atcaaacaaa
    18121 gccagctcag ctcctttttt aaaccgttct tctgcaaaat ccgtcacaga caagactcgc
    18181 atctcaccct gtaatccctg cgtattaacg attttcccaa cattaaagta gttcatcttg
    18241 tctcctgtaa tctccttttt tccatcttat tctgacaatt ctcgaataat agccgcaatt
    18301 ttttccgatt ctgaccattg taaataatgg tgattccttc ctaaaatgag tttagtattg
    18361 gaagtccaat attctgattc tctgtactct ttttctctat aagtctgaca aaaaataaat
    18421 acagggacat gagattctat cgacaaattc tcaaaatctt cctcagtaat ctctccagat
    18481 atctgaaatt ctggatcttg attttccaac tctaagcctt tttcttgcat taattcccag
    18541 atttttttat tcgtttcagg actaaatgtt gcttgagtta agttcttaaa ataaagttca
    18601 ggaccacact cgtcaatcag cctcatctac tcttccattt ctggataagg attttctgaa
    18661 aaatcagcaa acatgacttt tttagttgtc ggttcaattg ctactaaagt ctgacgctta
    18721 attggtttct cgagtaattt gcaagctaaa attccactcc aactatgtgc acaaagtata
    18781 tattcagaaa ttcctaattc ttcaagtact tcataaaccg catctgcaag attatctagt
    18841 ttttttccag cttggtcatg aatcggactc ctacctgtgt tcggaaaatc aattgtcaaa
    18901 taaccaattg taggaggagg tttttcaagt ataagtgaaa aattttcata acttggtagc
    18961 aaacctgctc cgtttagaca aactagcact ttcttttgct tttgataagt aacagagagg
    19021 ctaccaattt ctgtagatac ttcaaacctc ttcataaaga aatccactga ttctatataa
    19081 tgaattatta aaaatcctta tcctttattt tatcacgttc caaggatttt ctcaagttgg
    19141 aggaagggga caacatctct actttccctt caagaatcct tccaaattat gtttatgttg
    19201 gtaattaacg gctgcggttt tgtctttctc aaagacagtc ttggtaaggt caatatgatt
    19261 aatagctacg attgcgacgg tgtagtaaat gatatcagcc agttctctgg caagttcctc
    19321 gttcgaatcc tatcccttct tttcgaccag agcgcctatt caaaacctcg gctacttctc
    19381 cgacttcctc cactaacttc ataaagagac cttcatcagt ccgagactgc tgttaatgtt
    19441 cgattaagta gtcttggaat tgcctaaacg ttcaatcttt tatagtatat tgaaactaga
    19501 atagtacacc tttacttcta aaacattgtt agaaatcgat ttgactgtcc tgatcgattt
    19561 gtcctgttct tgtttcattt tactatatct tctattccac acaaaaaagc gagacatccg
    19621 tcccgccctt cttatttttc gtcaataacg attcttactt ttttgtattc agttgggaca
    19681 gagtagacaa tcgttcttat cgcagaaata gtgcgaccct tacgaccgat tacacgaccc
    19741 acatcgcttt gatcaagatt caaatgatat tccaaaaatt ctggtgtatc ctcaatcttg
    19801 atagttaagg catctggttg tgaaattaag ggtttcacaa tcgcaataat gagattttca
    19861 atcgtatcca tctgtcaacc tactttaaac ttattttgaa aatttagaat cgtggaattt
    19921 tttcaatacg ccttcttttg aaaggatgtt acgtactgtg tctgaaggtt gagctccatt
    19981 agccaaccat gcaagaacgc ggtcttcttt caaagttact tggttttcag caacaagtgg
    20041 gttgtaagtt ccaactgttt cgatgaaacg tccgtcacgt ggtgaacgtg aatctgctac
    20101 gttgatacgg tagaaaggtt ttttcttaga acccatacga gtcaaacgga ttttaactgc
    20161 catttttaaa gtctcatttc tttaattttt tatttcggtg aaatagctga gctatttagc
    20221 acatgttcta ttatagcaga tttctggcag gtgtcaagaa aaaaacttga cagactataa
    20281 atttcttaaa gtatttagaa atttgttaga ataggaaata aatgtttgaa agctgctatc
    20341 cgtgaatact attttagaaa aattttataa agaacaccaa gtcaaaccct tcatatcgcc
    20401 tgaacgagat ttggatactt ggctcctaag tcccaagccc gttcccaagc gaaatatgga
    20461 cttattagca gatgattcac tagcaggaga tatcatttta ctatggagaa tccagtttgg
    20521 tacttttacc actgaaacat gattttaaaa actcccattc gaatatgatt caaaattcgc
    20581 ttagaatcaa tgttttccca ctttttcaaa aaataaattt tcatctaatt taaataactt
    20641 tcaattaagt gtgaattttg cttaaaatca ttaaaaaaca ccccatggtg tgaaccatga
    20701 agtgttgcaa atgctgtgtt gtagctagat cttaacgttt agagaactgg ctagctttac
    20761 gagctttctt aagatctggt ttccaaaata ctttgagtac acttatggta ttgatgcccc
    20821 taaacatcta aaaactctgg tagaaaaagg gtatgctctt gtcgaaactt cttttgactc
    20881 acttgaccat ctaaatacta ccctgaaaaa gaatatcctg aagaagaagg gagttactgg
    20941 actttctaaa atgaaatctt gcgacctgga tcaagccctt catgagcatt tttcagaaga
    21001 agaattagct ggtcactttc atgtccttct atggactttt ttacaatggc attgctatca
    21061 cacccaatac ctatctaagc gcctggttcg taaactttat tgcagctctt cctctaaatt
    21121 tcctaattgt tgaaccaatt gcccgtttta tactaagttc ttttcagaaa ccatttactg
    21181 gggaagaagt tgaagatttt caagatgatg acgaaatccc aactattatc taatccagtt
    21241 ctgtaaacta ctaatatttg aaatccactt ccttttaggg tacaatggta taaatgaatt
    21301 tttgagagga tcagaatgaa aaaactagca acccttcttt tactgtctac tgtagcccta
    21361 gctgggtgta gcagcgtcca acgcagtctg cgtggtgatg attatgttga ttccagtctt
    21421 gctgctgaag aaagttccaa agtagctgcc caatctgcca aggagttaaa cgatgcttta
    21481 acaaacgaaa acgccaattt cccacaacta tctaaggaag ttgctgaaga tgaagccgaa
    21541 gtgattctcc acacaagcca aggtgatatt cgcattaaac tcttccctaa actcgctcct
    21601 ctagcggttg aaaatttcct cactcacgcc aaagaaggct actataacgg tattaccttc
    21661 caccgtgtca tcgatggctt tatggtccaa actggagatc caaaagggga cggtacaggt
    21721 ggtcagtcca tctggcatga caaggataag actaaagaca aaggaactgg tttcaagaac
    21781 gagattactc cttatttgta taacatccgt ggtgctcttg ctatggctaa tactggtcaa
    21841 ccaaacacca atggcagcca gttcttcatc aaccaaaact ctacagatac ctcttctaaa
    21901 ctccctacaa gcaagtatcc acagaaaatt atcgaagcct acaaagaagg tggaaaccct
    21961 agtctagatg gcaaacaccc agtctttggt caagtgattg acggtatgga tgttgtggat
    22021 aagattgcta aagccgaaaa agatgaaaaa gacaagccaa ctactgctat cacaatcaac
    22081 agcatcgaag tggtgaaaga ctacgatttt aaatcttaaa aaccaaaaaa aatacagtat
    22141 ccacattcgg tactgtattt cttttactct cattcttaag ttaaattatt aaaatcccat
    22201 atttggtcta tccaaccttc ataaaagtct ggctcatggc agaccataag gatagatccc
    22261 ctgtattctt tgagagcgcg tttgagctca tcctttgcat ccacatccaa atggttggtc
    22321 ggctcgtcca gcactaaaac gttgttttca cgattcatca agagacagaa acgaaccttg
    22381 gcttgctctc cccctgataa tacttgaatc tggctttcaa tatgtttggt tgtcaaacca
    22441 caacgggcaa gggctgcacg gacttctgct tgattaaggg caggaaaggc attccagaca
    22501 gcttcaagag gagtttggcg attaccacct tctacttcct gctcaaaata accaagttct
    22561 aaataatctc cacgctccac ttccccagcg attggcgaga taatgcccaa gagactcttc
    22621 aagagagttg tttttccaat accattagca ccaataatcg caaccttttg attgcgttcg
    22681 aaggtaagat ttaaaggctt agtaagagga cggtcgtaac caatttgcaa gttcttggct
    22741 tggaagataa agcgccctgg tgtacgagct ggtttgaaat caaaagatgg ttttggtttc
    22801 tcactttgga gttcgataat atccatctta tccaatttct tttgacgaga catagccata
    22861 ttacgagttg caacacgggc tttattacga gccacaaagt ccttgaggtc tgcaatctct
    22921 ttctgctggc gttcgtaggc tgcctctagc tgagatttct tcatagcata aacttcttgg
    22981 aactggtagt agtcaccaga gtaacgcgtc agctgttgat tttccacatg atagacaata
    23041 ttgataacgt cattgaggaa tggaatatcg tgcgaaatga gaacaaaggc attctcatag
    23101 ttttggagat agcgcttgag ccaatcaata tgctcagcat ccaagtagtt ggtcggctcg
    23161 tccaacagca aaatatcagg cttttcaagg agaagttttg ccaaaagcac cttggttctt
    23221 tgcccacctg acaaagaagt tacatccgta tccatgccaa agtccataac accaagagca
    23281 cgcgctactt cgtcaatctt agcatccaag gtatagaaat cacgactctc cagacggtct
    23341 tgaagttctc ctacttcttc catgagagca tcaacatccg cgccgtcttc agccattttc
    23401 atatagaggt cattgatacg agcttcagct ttgaaaagct catcaaaagc cgtacggaga
    23461 acatcacgca ccgactgtct ttcagcaagg acagagtgct gatccaagta accagccgtc
    23521 acatatttgg accactcaac ctttccttca tctggcagca ttttaccagt cacgatactc
    23581 ataaaggttg attttccttc accattggca ccgaccaggc cgatatgttc tcccttgagg
    23641 agacggaagg acacatcttc aaaaattgca cggtcaccaa aaccgtgact cagattttta
    23701 acttctaaaa tactcatttt aattccttat cttgttttta tgtaatcgtt tataaaggag
    23761 ccaagccaga tagccaccca aagtgttggt ccacaaatca tcaatctcaa agacacgatt
    23821 gaaatcaaag aaaaagtcca agattaattg cgtacactcg attccaagac tcacaagaaa
    23881 actaaaaaga aggacctttt ttgttttccg caaatttgga aatagataaa ggagttggaa
    23941 aatcagagga aaaaacaaga agacattgag gatattttgt aaaaaaatcc aacataattg
    24001 tccaatgtca ctcacttcgc ccagtttcca gagagaattg aaaggagtca aaagaaaaac
    24061 caggcgtcca agatgctgaa tatctggagt tcccactccc acggtagatt gttcttgagg
    24121 agtaaagcaa aaacagacaa tgcaaatgct atagaaaatg actccccaga ccaaaatatg
    24181 attataagtc ttcttcatca ttaaggattt accgctgcga ctgccttctg gcggtcacgt
    24241 ttcattgtgt tagagcgcaa ttgtccacaa gctgcgtcaa tatctgtacc atgctcttga
    24301 cgaaccacac agttgacccc ttttttctta agcgtatcat agaaagccaa cacgcgctct
    24361 ttgggactac ggctatattg gtcatgctca ctaactgggt tataaggaat caagtttgca
    24421 taagacaatt tcttgatgtt cttgagcaat tcagtcaatt ccaaggcttg ttctacactg
    24481 tcgttgactt cattaagcat gatatattca aaggttacac gacggtttgt tgtctcaatg
    24541 tagtattcaa tagcagcaaa gagtttttca atcggaaagg cacggttaat cttcatgata
    24601 cttgaacgaa gttcattgtt gggtgcgtga agagacacgg caagattgac ctgaacccct
    24661 tcatcagcaa agtcacgaat tttatgagcc aaacctgagg ttgaaaccgt gatgtgacga
    24721 gcaccgatag ccattccttt atcatcattg atagtacgaa agaaattcaa gacattgttg
    24781 taattatcaa agggctcacc gattcccatg acaacgatat ggctgacgcg ttcatcctga
    24841 ccacgctcat caaagtattt ctgaaccagc atgatttgcg ctacgatttc accgttattg
    24901 aggtcacgtt gcttcttaat caaaccagag gcacagaagg tacaaccgat attacagccg
    24961 acctgagtgg tcacacagac agataaacca tagtgttgac gcatgagtac agtctcaatt
    25021 aacataccgt cgggcaattc aaagagatat ttgactgtac catcagcaga ctcttgcaca
    25081 ataccttgtt tcaagggatt gaccacaaac tggtcattga gcttagcaat caaatccttg
    25141 gaaaggttgg tcatttcttc aaatgactgc acacgtttac ggtagagcca ttcccagatt
    25201 tgatctgcac ggaatttctt ttctccctgc tccaataccc attcctgcat ggtttgatgt
    25261 gccaaactat gaattgaggg tttcatttct tctccttatt ctctactcac ttctgacgaa
    25321 tgacaaaatg acgttgtccc ttgtcctctt tctgagaatg ctggtctttc tgacgacgtc
    25381 tattcttctt atctgcattc gactttcgtt tagtttgagt cggtttcttt ccttttctag
    25441 aaggtgtttc ttcttccgtc ttacgcattt tcttgtcaaa tgatgctcgc ttaggggctt
    25501 cattttctaa gacaaaatag gcacaaccat aactacaata ctctaaaagg tagtcttgta
    25561 aacgactgat tttttcaagt ttttcttctg ttcggtcatc cttgtaaaaa cctcgtaggc
    25621 gaagctgttc gttgctccag tcccccacga tataatcaaa cttggttaat acttctgaaa
    25681 aacgctgatt aaaagtcgtc acatcaaagg catccttgat attttcaacc aaggaaaaag
    25741 ctatcccttc cgtttcgacc ttgtccccgt gtaaatggaa ctccggacca ggaaacttgt
    25801 tatagttgta taattcaggt gcaatttctt ttcgcataga tatccttttt ccacgattac
    25861 ttaatacttt attctaccat aatttctagc agttagcacg tttctcataa aaatgaaaaa
    25921 agtctgacga ttttgtcaga ccagaatctt ataacctaaa aaagagaaga acaattcttc
    25981 cctccaacta tcattattta gcagctgcgt acaattcatc tactttattc cagttgatta
    26041 ctgaaaagaa agctttgata tagtcaggac gcacgttgcg gtatttcacg tagtaagcat
    26101 gttcccaaac gtccaagccc aagattggtt ttttaccttc tgagattggt gtgtcttggt
    26161 ttgctgttga agtcacttca agtttccctt ctttgttgac aaccaaccat gcccaacctg
    26221 aaccaaaacg agttgttgct gctgcagtga aggctgcttg gaattcttca aatgaaccaa
    26281 atgttgcatc gattgctgct gccagttctg ctgaaggagc tgttttctcg ggagtcatca
    26341 attcccagaa aagagcgtgg ttcaagtgtc cgccaccatt gttgataagt gcttgacgga
    26401 tatcagctgg gatagattct acatcagcaa gcaaggcttc aaggtcttca ccgatttcag
    26461 ggtgtttttc taaagctgca ttggcattgt tgacataagt ttgatggtgt ttgtcatggt
    26521 gcaaatgcat tgtttccgca tcgatgtatg gttccaaagc gtcgtatgca tatggaagtt
    26581 ctggtaagat aatagccatc tgtaatacct ctttttcttt ctatatgaaa atgataacgc
    26641 aaacattcac ttttttcaag ttttttgctt atagataagg aaatcactga catactttct
    26701 aataaaataa gcaaatcagc aagaaaccca cgacaagata atcctgacgc gggttgtagt
    26761 ttcaacaaat gtcaattgac ctgactagca atctgtaaga gtgccttttc aaaaaggaaa
    26821 cctttttcat aaagacctgt cttaatctga tagtctgtct caatcaaata ggaaatagct
    26881 tgcttcagaa agctcaaaga aagtcctctc gaatctctta atgcaaactt gatttgataa
    26941 ggatttgggt tacgtcccag ataactacct aaactacttg caatctgcga ttctgtttgg
    27001 ccagactccg ccaaaatctt cacctgagta aaagtccgaa attgtcccag catgactgca
    27061 atcagtttga tttcatcttc cccttgcaag gtcaagtctc tcaccaaatc gcgcgcctga
    27121 tccatctttt tagtcagaat aaactgagtt aaatcaaaaa tattgtcctg caaggtcttg
    27181 ggaattgcgt taacaatatc ctcttcctcg ataacagaat ccgccttata ggactgtaaa
    27241 aagagaagat ttttctggat ttcgctaaat tgaaaccccg acttgatgag gagattttca
    27301 aaagaatgat tggtaaactg cagaccttgt ttctgactcc acttttggaa atactggcgc
    27361 aattcttgtt cttttacttc tactgcatcg aagaccttgg catcacgctt aagtaatttg
    27421 actaaccgtc ttttgctatc cagctttcct tctgcaaaga ttatcaactt agttgttgga
    27481 gaaggattgt caaggtattc ctcaaatgac ttaagctcat catctgtcaa aaagcgtttc
    27541 ttagcagtcg tgatatccat aaaataatct aatatcacga ttttctcatc cgcaaagaaa
    27601 ggaaggctga ccaactccag ttccacatcc ttgtaaacta cttctttcat atcaaagtag
    27661 gcaaagttga ggtcagcaga atcataccca atctgtttca acatttgact cttcatcact
    27721 tcaaactgac cctgatctgt ccctgtaaat aggctcaggc tcggtaaatt tgataaagtc
    27781 aacttctgac tttcttcaat ggctagcatc gactctcctt tcttcagatt tttcgattta
    27841 atttagtcaa tatagcgcaa tttcccacgg aaatcttcta agctctcgta gcctttttcc
    27901 accatgattg ctttcagttc attggtaatg cggtcaaaag cactgacgcc ttctttgtga
    27961 agggtcgttc ccacctgcac catacttgct ccacagagga tgtgttcaaa ggcatctcga
    28021 ccagtcagaa cgccacctgt tccgataatt tggatttgag gatttaaacg ttgataaaag
    28081 gcgtgaacat tggctagagc agtcggtttg atgtattctc caccaattcc accaaaacca
    28141 ttcttaggcc gaataacgac agattcgtct tctatataga ggccgtttcc gatagagtta
    28201 acgcagttga caaacttgag cggatatttg ttgaaaatag ctgccgcttg atcaaagtga
    28261 acaatatcaa aataaggtgg caatttaatt ccaagaggtt tggtgaagta agcaaacact
    28321 tctgccaaaa tccggtctgt tgtctcaaaa tcataggcaa tctgaggttt acctggaaca
    28381 tttggacagg aaagatttag ctcagtcaga ccacgaaaat cactctcttg gacttttttc
    28441 aaaatagtat gggtttcctc tggagacatg ccgaccagag ataagaataa agttcggttc
    28501 gactcttttt cctgcaaatc taaaagataa tccaaataat agtctaagcc attatttggc
    28561 aagcccatag agttgatgga accaagtgga acatcttggt agcgtggctc aggattcccc
    28621 tgacggaagt ccaaggtcgc tgtcttagta acaaaggttc ctgccgctga gtttttgacc
    28681 tcttctaact cctctatcgt catacaagcc acacctgctg cattcatcaa gcaattgtca
    28741 aactcaaaac cagcaatttg tgttttcgtt gataccatga ttctaatcct ccagatttct
    28801 tttattgcta atattatacc ataattttaa ttctaggttt actagattct gtggttctat
    28861 ctatttattc ggaaaagaaa gtctagtaca gaagtcatgc tatggaaaca gctagtgtat
    28921 tagaagtttg aacaaggctt gggtaacaga cttttgaatg aagtccaagc aacaaggaga
    28981 aatctcaacc atgagtccat tccatgactc tgttgctcta gaaaaccttg caatagtcaa
    29041 gtgataacga ataaaacttt ggattgaaat atccccaaga ttatctatta cgaggagaaa
    29101 tcttaacctt tatcattttt aaagaaatat agtaaaatga aacaagaaca ggagaaatcg
    29161 atcaggacag tcaaattgat tgctaacaat gttttagaag ttgaggtgta ctattctagt
    29221 ttcaatctac tatacatgta aatctctact ttcgcaaaat ggattttcag aacagtatcc
    29281 cagtatagtt aaaaactata aaaaagagag gacgttcccc tcttaaaatc ttattttact
    29341 gcttctttca aagcatctac cttatccaaa cgttcccatg gaagatcaat atctgtacgt
    29401 cccatgtgac cgtaagccga tgtttgacgg taaattggac gcttgaggtc cagcatttgg
    29461 ataatccctg cagggcgaag gtcaaagatt tgacgagccg ctttttcaag ttgactttca
    29521 gctactgttc ctgtaccgaa agtatcgata cgaacagaaa caggttgcgc aacaccgata
    29581 gcataggcca actgcacttc tgccttctta gcaaggcctg ctgcaacgat attcttggca
    29641 atatagcgag ccgcataaga ggctgaacga tccaccttag tcgcatcttt accagagaag
    29701 gcaccaccac catgacgaga gtagccacca taagtatcta caataatctt acgaccagtc
    29761 aaacctgagt ccccttgagg accaccgatt acaaaacgac ctgtcggatt gataaagaat
    29821 tttgtcttat catcaagata agaagatgga ataacttctt tgatgacctt gtcaatcaca
    29881 tcttgatgga tttgttcatt agtggcctct ggatcatgct gagtagaaat aacgactgta
    29941 tctacacgta ccggacggtc attttcatcg tactcaactg taacttgtga ttttgcatct
    30001 ggacggagat agctaatttc tccagactta cgaagttctg ccagacgacg aaccaattta
    30061 tgactgagtg caattggcaa tggcataagc tcttctgttt catctactgc aaatccaaac
    30121 atgagccctt ggtcacctgc tccaatcaag tccagtggat cttgatcagc atttccacga
    30181 acctccaagg cttcgttaac accttgagcg atgtcaggag attgttccac caaagatggg
    30241 tgtactccca ccgtctcagc agaaaatcca tattctgtat tggtataacc aatctctgca
    30301 atggtatcac gaaccacacg gttaatatcc acataggcat ttgtagaaat ttcaccaaaa
    30361 acgtggacag aaccagtata tacagctgtt tcagcagcaa cgtgcgcctc tggatccttt
    30421 gctaaaatag catccaaaat cgcatctgaa atttggtctg caatcttatc cggatgcccc
    30481 tcagatacag attcagacgt gaataattta cgttctgaca taaaaatgtc cccccttaaa
    30541 aaatattgtt atagagttac aaagtactga taggaaaact cttcgtaata aatacctacc
    30601 atcttatcgg gactatataa ctttatcatt ataccatttt taatcgcaat ttgcagtctt
    30661 taatgtagtg tttcggttta gatagttcgt tctcataaag caaaaagttg gagctcagta
    30721 ctccaacaat ttctattaaa atgtttgacg tttagcttta cgctctgcac gaccgcgagc
    30781 gcgattttca gcacgcttgg ttttacggcg cttttcatca accgcccatt gaattttctt
    30841 cttataaccc ggtttgactt ttttcttttt ctttttaacc aaaccaatca tttcgatatc
    30901 aagtttatct tgttttttct cacggttggc acgacgatca cggtcatagg tatcttgaaa
    30961 ttccccgtct ttgaccatct taggactaaa cttgattccc aatttctcca actcacggat
    31021 atccgagtca tcacttggct gataaagggt aatagctgta cctggtaggc catttcgtcc
    31081 agtacgacca acacgatgaa caaaaaaaga taagtcttgc ggaatggcat cattgatgac
    31141 atggctgaca ccttcaatgt caatcccacg cgctgctaaa tctgttgcga caatatactc
    31201 aaaatccaga ttttgcacct gattcatgat tcgcttgcgt tcacgagggg caatatcgcc
    31261 atggattttt gcaaccttca aaccttgaga agtcagatat gaatgcaatt catcagcacg
    31321 cgttttagtg ttaacaaaaa tcattgccaa atacggctgc atcaactgag tcaaccagta
    31381 aatttgagca ttcttatcat gtcccttggt cgaaatcaac caattatcaa tggtgtcaga
    31441 aataaccgtt ttagtcttaa ttttctccat aacaggattt gataagtatt ttttcaagaa
    31501 tggttgcagt ttttgtggga tagtcgctga gaagaccatg aattgcaagt cttttggaag
    31561 actgccagca atcttatcaa cagtttccaa gaatcccata tccaaggtca tatctgcttc
    31621 atcaacaaca aatgtcttgg ctttatgaat agctaaatca ccagatttaa ccaagtcgta
    31681 gatacggcct ggtgttccaa taacaatatg aggctgattg cttgccaatt tctcaatctg
    31741 gcgagcctta tccgtaccac ccacataatt aaccacacga acttcgacat ctgagtgagc
    31801 tgaaatctga cgcgctactt ggtaaatttg agtagccaac tcacgactcg gtgcagtaat
    31861 cactgcttgt acactatcgc tagcttcatc taattgctgg aaaatcggta acaagaaagt
    31921 atgagtctta cctgaacctg tttttgattc tcctactagg tcacgacctg ccaaaacaat
    31981 aggaatcaac ttgtcttgca cctctgttgg agttgtaaat tttaactcct tcaaggcttc
    32041 tctaatatag tttttaaatt gaaatttcgt aaatgacata acatcctcga ttctatctat
    32101 cttatcaatt ataccatatt ttattccatt acagtagtct cacttattta ggctatttcc
    32161 agtagcttct ctagtaagaa aaggctggaa ttttatagtt ccaacctctt ttcagttatt
    32221 atttccagtt taatatagca ttcaagccat agtgatcact cacttgtgga ctcttgttac
    32281 catcaaatac gacatgtaaa ttttccaccg ctaactcttt ggtagtaaag acataatcga
    32341 ttcgaagggg ttcagtgttc cctttccagc catcaatttc aggcggaaca gtatagctac
    32401 cacttttctc ttgagcaact tcaaatgcgt cttgtaagcc taatggacta gctaaaatag
    32461 cttggtaacc ttcctgacct gctgggttgt taaaatctcc agctagtaaa agtggcttgt
    32521 tcaatttttt caagacagcc tcaaatcgtg cccattcttc ttggaaacct ttatcccacc
    32581 aagagagatg aacactggca actgctagct ccttgccatc gactacagtt tcagctaggg
    32641 caacacggcg agtatgatag tctgttggat catccacatc tgaaaccaaa atttctctgg
    32701 cttcaatagg tgttttagac aagatagcca caccttcgtg gtagcggtca tagccgatat
    32761 ggttataagc ccaggtccag tagtaatttt tcccttgctc taacaacttt tcaaccaaga
    32821 gtctaacata atggtcttgg tgaataggct cagctgctgg caaagcttga taaaggtcat
    32881 taacctccac ctctgacgag gtcatctcct gattgatttc ttggaaacaa atcaaatcat
    32941 agtccttttc aagaatatct tcaagcaaaa tctggaattt ttcctctgct tctttctcca
    33001 tccaactgtg agtattgagt gttaaaaatt tcattctttt ctcccaaaat aagaggttgg
    33061 aatacagctt ccaacctcaa gtatattaca attctacttt agcaactgct gttttagctg
    33121 caagagaacc tgttttttct aatttaactg atttaattgc atcaccattt gtgaagacaa
    33181 ctactgttga agtttcacgt cctgctgcac ggatagcatc caagtcagct gtgacaagga
    33241 gatctcctgc tgcaactttt tgtccttcag caacatgaac tgtaaatggt ttaccttcaa
    33301 gacttactgt gtccaaacca atgtgaacca atacttcaag acctgcttcc gtcacaatac
    33361 caaaagcatg ttttgttggg aagatgcttg acacagtacc tgaaactgga gatacaatgt
    33421 ttccatttgc aggttctact gcaaatccat cacccatcat tttttgagca aatactggat
    33481 cctttacttg ttccaaacca acaacttgac cgtctgctac tgagtaaact tcctcagtaa
    33541 gatctttgaa gtgaacagtg ttttgttgtg cttcagtcat ttggcttgga agagtttcag
    33601 gaatgatttc acctgaatca aggatatctt ggatatcaga tttcaaaatg tcagcttttg
    33661 gaccgtagat agcttgaacc ccttgtcctt tcatcacaag acccatagct ccttctgctt
    33721 tccattgctc tgcatttcct actttatctg catctttaac agttacacga agacgagtca
    33781 tacatgcatc aacatcaacg atgtttacac gtccaccaag aaggttgata atgtttacag
    33841 cttgagagcc tgctgcaact ttcacttcgc tgctggtttc ttctgaacct tcagcagttt
    33901 cgtagtttcc gttgcgccct ggagttgcgt agttgaattt ttgaatcatg aagtttgcga
    33961 taaagtacat gattacagca aagagaacag ttacccaaac gaagttaacg atatccatac
    34021 caataccagc actgattgca ataggtgtac gagtcaagaa ctcgattgaa ccgaatgagt
    34081 gcatacgtag gtttacgacg tcagccatag cgaaggcagc accttgaaca agtgagtaaa
    34141 caagatacat aggtgttgcg atgaacatga acatgtattc gattggttca gtaacccctg
    34201 tcaagaatgt tgcaagagct gttgcaatca tcataccttt gtatttatgt ttcttgtcag
    34261 catcaacatt acggtagata gcaacaatca cacccatcaa gataccgaat gaaccgatca
    34321 tttgtccaac tttgaaacga gctggatgta ctgtatctaa caagtgttga tattgactag
    34381 catcagtacc tttaaggttt acaaggtctg ttacccatgc aagccatagt gggtcttgac
    34441 cgaatacttg agtaccttta gctgcaccag ttaaaatgtc ataagtacca ccaagagctg
    34501 tgtagttcat tgggatagtc aacatgtggt gaagaccaaa tggcaagagc aaacgttcca
    34561 aagtaccata caagaatggt gcaagaattg gagcagtttc ttgtgagttg gcaatccaga
    34621 taccgaagtt attgatacct gtttgaacta ctggccagaa agcagcaagt agaattgcag
    34681 cgattgctga acgaagaata actacaaatg gtacgaaacg tttcccgttg aagaatgaaa
    34741 gtgcatcagg aagtttacgg aagttgtagt atttgttgta agcagttgcc cctacaaaac
    34801 ctgagataat ccctacgaat acccccatgt tcaaggctgg agcttcaaga acactgataa
    34861 agtaatcagc aactttgatt gaaccaccaa agaaagtagt taccatagca tctggatttt
    34921 tcaacatatc gcctgataca ccaaagattg taccagtgat acggttaatc aagatgaagg
    34981 caagaccagc ggcgaaagca ccaccagcac gttctttagc ccagcttcct ccaatggcta
    35041 gggcaaacaa aatgtgaagg ttaccgataa ccccccaacc gatttgctca agaattccac
    35101 ctgtgatgac aagtggtgta aaggttgggt taatcatcac gatagactta ccgattgaaa
    35161 tcatcaaacc agcagccggc ataaccgcga taactaccat caaagcctta ccgaattttt
    35221 gccaaaattc gaaagacaag acatttttga atgtatcttt catcattcaa atctccttta
    35281 tttttattta ggcaaacgtt ttacgaaaac gtttgcacct tctataattt aattatacca
    35341 ctttaatttt ttttgtaaag gtttttataa aaaaattaca cttttttcta aaaaatttct
    35401 agtgagtcaa atttcaagtt caaattagcc atcaagaagt cttctctaga ggacttcttt
    35461 ggaagctctt ttcttctacg catctctttt caaaaactct tgtagcaaaa aaggagattt
    35521 tacaatctcc tcataaaagc agctatttta cctaaatctt caagaatcgg cgcatggata
    35581 ttcctgatcc caatgaacca atgaaaaccc caatcacaaa tagtagggca atcatcaacg
    35641 gactaaataa atctggacta atcatggata gattttgccc taccaacgat ttgttgacag
    35701 attggtaaac aatttgataa acaataaaga ccaaaacaga tggtgcgata gctcccaata
    35761 aaccgataaa ggctccttct aacaagaacg gtccacggat ataactgttt ttagctccga
    35821 ccaagcgcat gatttgaatt tcgcgactgc gggaaataat ggtaatacga atggtatttg
    35881 aaatcaagaa aactgcgata aaaattaaca aagcagcaat ccctagtccc caaacacgga
    35941 taaatgaagc taacttgaag agtctttctg tattggcacc gccatcttga acctcagaga
    36001 caccttcaat ttttttagca tcttcggcta tagtttttac atcatttgga gtgtttgcct
    36061 ctacaatata ggcatcatag agaggattgg catctccttc aaagattttc cagttatctc
    36121 ccattatctc ggttaatttt tcatattgtt cttctttact tgaaaaggta acacttttaa
    36181 ccgtagacat gttcttcaaa gaatcatata ccttgtggta gtcattattt gtaacagttt
    36241 gaccttcttt ttcaattgtc tgactattat cttccacatc ctttcggata taaactacta
    36301 cacggacatt attttcaata tctgtagcta gtttcgctgt attgaaaata acagatgcaa
    36361 atattgccac caaggtcaaa gtaatcatga ctgaactgac agcagctact gtcatccaac
    36421 catttcgttt caaacttttt aaggcttcaa ataaatggcg aaaaaatcta ctaatcatcg
    36481 tatccatact ctccttttga ttcgtcacga acgacacggc cattttcaat ggcaatgaca
    36541 cggtggcgca aggtatttac aatctggcta ttatgagtcg ccatcaaaat agttgttcct
    36601 tgtaggttaa tccgttccaa gagattcata atttcccatg aattatccgg atccagattt
    36661 cctgttggct catcagctat caatactttg ggattattta caattgcacg cgcaatcgca
    36721 atccgctgtt gctccccacc tgagagttca tttgggaaag aacgaacctt atgcttcaat
    36781 ccaaccaagt ccaaaacttc catcactcgt cttttgatat tacggcgatt ttccccgatt
    36841 acttccatag cgtaagcaat attttcatag acagttttct ttggtaacaa tttataatct
    36901 tggaagacaa ccccaacact acgacgtaga agcgggacat ctttcttttt gatcttaacc
    36961 agattaaaac cagcaactga tagacttcct ttatcgattt ttacttcacg atacagagaa
    37021 cgaataaaag ttgacttccc tgctcctgaa ggtcctacga tgtaagcaaa ttcccccggt
    37081 tgaacgctaa ccgaaacacc gcgtagagca gtcgttccgt tgtcgtattt tttaacgaca
    37141 tctctcattt caataattga catgtgagtt cctttctatc ttagctaatt cgccacttga
    37201 gataagcatc gataaaacca tctaggtctc catccataac cttatctacc tgagcaacct
    37261 catagctagt tcggtgatct tttaccatag tataaggcgt gaagacataa gaacggattt
    37321 gacttcccca agtgatctcc tttttctcac ctttgagaga atctacctcc gcagccttct
    37381 tctcttgctc catttgatag agcttagcct gcaacatctt catggcgcga tctctatttc
    37441 catactgggt acgatccact gttgattgga caacaattcc agttggaatg taggttaaac
    37501 gtacacctgt tgaaacctta ttgacgtttt gtccaccggc accacctgaa cggaaggtat
    37561 ccatcttgat atcatcttca cggatttcca cttcaatagt atcatccaat tctggcatca
    37621 cttctacaga tgtgaaagag gtatggcgac gtttggcaga gtcaaatggt gagattcgca
    37681 ctaagcggtg aacacccatt tctgacttga ggagaccata ggcattaggc ccttcaaatg
    37741 ataaagttac cgacttaata ccagcctcat cacctgcttg gtaatccaac acttccactt
    37801 taaagccttt agcattacca taacgagtat acatacgaag caacatatca ccccagtcct
    37861 gcgcctcagt accaccagaa cctggatgga tttccaagat ggcattgttg tggtcataag
    37921 gttctgacaa gagtagagtc atctcgtagc tggtcattat cttatcaagt tcggctaact
    37981 gcgctaccag ttcatcatgc actgactcgt cttcagccaa aaaatccaat aaaatttcga
    38041 cttcatcctg caactcttcc atcttatgga aggtattgta agtgtttttt aattcattta
    38101 attcttgcga cattttttgg gccgcaatat tatcgttcca aaaatcaggt tctgtcatct
    38161 tgttttccaa gatggcaatc tcttcctcta gcccttcgag gtcaaagaga ccccctgaaa
    38221 gaagctaatt tttcacgatt tgcgtcaatt ttctgacgaa ttactgaaat gtccataaat
    38281 actccttttt tacattattt cattatagca tattttatca tttctttcca tcttttgctc
    38341 taatcccctt ttcatgaaaa aagaagcctt tgggcttccc ttcttacaag acttttgctg
    38401 aagtgcgaac gatttcttcc acttgaatac catttgcttc aaatttttct ttcaaggctg
    38461 gtaaatcaat tgatccatcg atttgcactt cgataatcac cttaccatcc ttacgcggaa
    38521 tattgactgt atgggagata ttcaaatttt cttctacaat caaagaaaca atttttccaa
    38581 gaacaccaac ttcatcttct gtaacaaagc gtacacgaat cccttcttcg ccataacctg
    38641 caatttcaag aaaggcttgg aaaacgtcac ggtcagtaat aactccgtat acttgatggt
    38701 tatctacgac agggagaata ccaatcttat ttttcaacat cagataagtt gcatcttcta
    38761 gactagcata gcctgagaca gtgacaacat cgcgaatcat gacatctttt acttttgtct
    38821 tattcagaag ataattcatc tcatagatag aaagacttgt tgctttagat ggacttgctt
    38881 gtgcaatggt tccctcagtc accaaaccaa ccaattgatc attttcgata acaggcaagc
    38941 gatgcaattc ttgctctctc atcaaatctg ctgcatgaga tactgttgta tctggactaa
    39001 tataaactac cttgcgggtc ataaaatctt taactgccat gagacttctc cttttctatt
    39061 cttatcccca ttatacaatc tttttgtaaa tctatcaaac gcttacattt ctttttcgaa
    39121 attcaaaaaa gtatgaataa gctagcaaaa agagctctga aatagagctc tgtgaatgaa
    39181 ggtaagaaat ttttcattcg attttttcaa ttattagaaa ttaagctttc aatgtagatg
    39241 catatttgtt tgcaatctct atccaccgac taaaaaggtc cccaggacta tattgatgat
    39301 tacttcgtaa tctccatctg ccggctaaaa caatcctctg gatttgatga ttgcttcgca
    39361 atctttatct gcaacctaaa ctagtctccc agactataat gatgattact tcgtaatctt
    39421 catctgccga ctaaaacaat ccactggatt gttttagcta cctagatatg cttttctgac
    39481 ttcttctgat gaggcgagtt cttttcctgt tcctgatagg acgattttcc ctgtttccag
    39541 tacatatcct cggtcagaga ttgcaagtgc tttattggca ttttgttcaa tcaagaggac
    39601 ggttgttcct tgcttctgaa tatcttgaat gatatcaaaa atctcttgga tgaagattgg
    39661 ggcaagtccc attgatggtt catctaaaag aagaagtttt ggtgttgaca taagagcgcg
    39721 tcccatggca agcatttgtt gttcccctcc tgaaagagta gctgcatctt ggttcttacg
    39781 ttcttcaaga cgaggaaagc gtgagaaaac cttcttcaag ttagcttgat tttcttcacg
    39841 atttttcttt aagaaagctc ccatttcaag attttccata acagtcaagc caggaaagac
    39901 gtggcgtcct tctggaactt gtgaaagacc acctgccaca attttctgag ctggcatttt
    39961 ttggatttct tgacctaaaa attcaatctt tcctgaactt ggtcgaacca aacctgacaa
    40021 ggtgcgaaga atagttgtct tacctgcacc gttggcaccg ataagggaaa caacttctcc
    40081 ttcattaact tcaaagctta catcacggac tgcttggatc ataccgtaat gcacagaaag
    40141 attttcaact tttaacatag acattaggct tcacctccta gataagcttc gataacgcgt
    40201 ttattggtct taatttcgtc tggagttcct tgagcaatta aacggccata ttcaagtacg
    40261 tagatacgtt ctgttacttc catgaccaga ttcatatcgt gttcaatcaa catgattgta
    40321 atcttaaatt catctttgat acgacgaatt aactcagtca attcggctgt ttcctgtggg
    40381 ttcatacctg ctgctggttc atctaagaag agaattttag gttccgtagc aagggcacga
    40441 acaatttcca aacgacgttg ttgtccgtag gaaagatttt tagcaagagt ctctgcatca
    40501 ccatctaaat caaagatttt caacaattcc aaagctttag cctttaattc tttttcactc
    40561 ttgtaaaaag ctggtaagcg taagaaacta gtaaaaacat gttgtttgtg atggtttcca
    40621 aaagcaatca aaacattgtc taaaactgtt aaatctttaa agagacggat attttggaaa
    40681 gtacgtccaa gtcccaaaga ggcaatctta taaggtgatt tcccattcaa aaggtgacca
    40741 tctagggtta ctgttccctc gcttggttca taaacaccgg tcaaaaggtt gaaaagggtg
    40801 gttttcccag ctccgtttgg accgattaat ccaaccagtt ccccttcgtt caattcaaga
    40861 gtcacatctc caacagctgt tagaccacca aaatgtttgg ttaactgttt tacttcaagt
    40921 aatgccatta gttttgttcc tccttcttag attttttaaa gaaacgtgat aggctcagtt
    40981 cccacgttcc aaggagtcca cctggtctga aaatcattac caataccaag gccaaagcgt
    41041 aaataatcat acgcacacta gcaacatctt ggagaagcat attcaaaatt cccagaacaa
    41101 tagccgaaac aatcgcacct gtaatggaac cgagtccacc aaatacaaca ataatcaaaa
    41161 cgttgattga gttgatgaag gtgtaatctt tcggtacaac agacccgata aatcctgcct
    41221 gaagtgaccc agcaatactt gcagtaatgg caccaaagac aaaagcgatg attttaattt
    41281 tagtcgtatt aaccccaact gactcagcag cgatttcatc ttcacgaaca gagagggttg
    41341 aacggccaat tgggctacgc aagaagttca aggttgcaat ggttgtaatc acgacaaaga
    41401 agtaaaccat ttgccaagtt gtaaagttag gaatccctaa gatacctgcc gcaccatttg
    41461 taagacttcc accattgatg ataaagatac ggataatttc agaaacaccc agagttgcta
    41521 ccgcaagata gtcccccttc aagcgcaagg ttggaatgcc gacaagtaag gcaactgctc
    41581 ctgaaagcaa agcccctaca agcatagctc caaagaaggc accgtaggtt ggtgatttag
    41641 aaccaataat agctgctgca taggcaccaa tcgccatgaa accagcatga ccaagtgaaa
    41701 attgtcctga aaaaccaacg attaagttga gaccaacagc caaaataata ttaattccaa
    41761 tttgttgtaa aatctgtaca tagaatagat taagtactcc gactgaaacc agtacactaa
    41821 tcaagctata gccagctaac aaaaggagta accatagaat attaactttt aaattttcct
    41881 tcatcgttta caccttctct ttcacattct taccaaggat accagctggg cggacaatca
    41941 agatcaacaa caagattcca taaacaatgg catcacggaa atctgacatc ccaaaggctg
    42001 tcgcaaaggt ttccaataga ccaatcacaa agccaccaag agcagcacca ggaataattc
    42061 cgataccacc aagtactgcg gcaacgaaag atttaagacc tggagtaacc cccatcaaag
    42121 gctcaagaga gttataataa agagcaatca gaacaccagc cgcacccgca agagcagaac
    42181 ccaaagcgaa ggtaaagcta atcgtacggt ttacattgat ccccatcaat tgcgccgcgt
    42241 cgctatctac tgatactgca cgcatggctt tccccatctt agtcttttgg acaatgactt
    42301 gtaacaaaat catcaaaatc aaggaaatgg ccaaaatcat taactgcaca tttgttaagc
    42361 taattggtcc caaatcatat cgaactgttt gaatcgcttg agggaaggca cgggtattgg
    42421 caccaaccag atagaccatt ccatactcca ataggaaaga aaccccaata gccgtaatca
    42481 aaacagcaat acgagtagag tggcgcaaag gtcggtaagc aagaaactca atcacgacac
    42541 caagaatagc tgtcgctagc atagctacaa taagcgctac aaagaaattc atttggaaag
    42601 aattgatcaa gaaataaccg ataaaggctc ccatcatata aatatcacca tgggcgaagt
    42661 tgatgagctt gataattccg taaaccatgg tatatcctag ggctaacagc gcgtaaacac
    42721 tacctagaat caaaccattt acgagttgtt ggagcataag attcactctt tctatttata
    42781 attccgaggg gtttccctca ctttttgata ggttcttata ctcaatgaaa atcaaagagc
    42841 aaactaggaa actagccgca ggttgctcaa agcactgctt tgaggttgta gataagactg
    42901 acgaagtcag tcacatatat aatccaaggc gacgttgacg cagtttgaag agattttcga
    42961 agagtattaa atatcgaaac agggagtgag tcaaaggctc attccctatt tcaacatttt
    43021 tctattatgg ttttacaact tctgctgctt caactttacc attgttcatg gtcatcatgt
    43081 aagcagtttt gactgtgttg tggtctgcat cgaagcttgt ttgaccagtt acaccttcaa
    43141 aatcttttgt tttagcaagg ttatccttga tttcacctga atttttagca ccttttgctg
    43201 cgtttgctac aaggtgaact gaatcataag ccaaggctgc aaatgttgaa ggctcttcat
    43261 tgtacttagc acggtaagcg tcaaggaagg ctttagcttt agctgaaact tctacagtag
    43321 ttgagaagcc tgagataaag tagatgtttg atgctttttc agcagttgct tgttgtacaa
    43381 actcctcacc gttgaatcca tcaccaccaa cgattggttt gtcaattccc atgccacgcg
    43441 cttggtttac aatcttacca gcctcattat agtaaccagg aacaacgata gcatcaaagt
    43501 ctttcccttt catttttgta agggctgctt gaaagtctgt gtcacctgct acgaaagttt
    43561 catctgcaac gatttcaccc ttgtatgact cgcggaaaga tttggcaatc cctttagcat
    43621 agtcactggc attgtcagtg taaagaacaa ctttcttagc atttaatttt tcagaaacat
    43681 agtttgagat aatttttcct tggaagctat cttggaaagt tccaataaag aggtaatctt
    43741 gacctttagt caatccatct tgagtcgcac ttggtgagat caatggaaca cctgcttttg
    43801 tagcgttcgc taccgcagct gcagtcgcac cagatgtcgc aggtcctacg actgctgata
    43861 ctttagattg ggttacaagg ttagttgtaa ctgaagcagc ctcagctgtt tcagacttat
    43921 tatctttatc gactacttcg atttgttttc catcgatacc acctgcggca ttgatttcat
    43981 caacagccaa ttgggcacct ttttgttcag ctgttccgta tgcagctaaa gaacctgatt
    44041 cttcaaagtt aaacccgatt ttaattgtct tttcctctac tgagttacca gcagtgttga
    44101 ctgctccaga cttcacttct ccacaggctg caagaagtgc tacacttgca agcgccacaa
    44161 acgatagggc aaattttttc ttcatctttt tgtctcctta tttcttaaac agtctgttaa
    44221 aaatataccg aattatcaga aaattgtcaa tgttttcctt gaactttttc gatgataacg
    44281 ttttcctatc gataaagatt gcccacaaag ggtgtttcca actcttggat atgacaaacc
    44341 ctaacttttt taataaattt ttccttgctc aagcgtccga ccaattgctc cacttcttga
    44401 gttggaacat agagttgtaa gtaacgatgt ttcttggaat gataggtaat atctccataa
    44461 tcctgcagtt ttttggcatc acgattatag taaagataga taatcaagcc agagcgattg
    44521 actttttcaa acatgataaa tcctctttct aagaaatctc tccctattat accaaaaaaa
    44581 gcaaacccag tcgagtttgc cttctatcat cattagttca atgaattgtt ggccataatt
    44641 tcatcaataa agccatattc aagtgtttcc tgggcgctca tccagttatc acgttctgca
    44701 tctgcatgga ctttttccat tgactgacct gaattttcag ccaagatttt ttccaaggta
    44761 ttacgagttt tgagcaagtg ttctgcagcg atagccatat cagtttgttg ggtaccacca
    44821 cctgtaccgc ccattggttg gtgaatcatg tattcagcat ttggaagcat gaaacgtttg
    44881 ccttttgctc cacttgatgc gatgacagtc cccatagatg cagccattcc cataacaatg
    44941 gtttggacat ctgccttgat aaagttcatg gtatctacga ttgccaaacc agctgaaaca
    45001 gaaccacctg gtgtattgac ataaaggtaa atatctttcg tactatcttg ggcatccaag
    45061 aaaagcaatt gggcaataac agagttagcc atattgtctt caaccggacc tgtcagcata
    45121 atgatgcggt ctttgagaag acgtgagtaa atatcgtaag aacgttctcc acggcttgtt
    45181 tgttcaataa ctacaggaat cattcatttc tccttttgag ttttaatttt gttggtcaaa
    45241 tgactgaaga taagactatt ataatatctt ggtcaaaaaa ggtcaaattt ttgctctgct
    45301 ttcattagac agaaacaaaa acccaacctc ctttcgtgac tagaaatact tttccaagtc
    45361 attcttcttt tcgatcttat tttgtaccga acaagcggtc tccagcatct ccaagacctg
    45421 gaacgatata accgtgttca ttcaaacgtt catccaaggc tgctgtaaag atttctacat
    45481 ctggatgagc ttcttgaagg gcttttacac cctctggagc agatacaagg cagacaaatt
    45541 tgatatttga tgcgccacgt tttttaagag aatcaacagc caagattgct gagccacctg
    45601 ttgccaacat tgggtctact acaaaaattt gacgttggtc aatgtcctca ggcaatttca
    45661 ccaagtattc aactggttga agtgtttctt catcacggta cataccgatg tggccaactt
    45721 tagcagctgg aaccaagctc aagagaccat caaccatccc gatacctgca cgcaagattg
    45781 ggacgatggc caatttctta cctgccaatt gtttttgaac tgtttttgta attggtgttt
    45841 cgatttccac atcttctagt ggaagatcac gaagtacttc ataccccatc aacattgcaa
    45901 tctcatctac tagctcacga aaagcttttg tagaagtatc tgtacgacgc aagattgaca
    45961 atttgtgttg aatcagtggg tgattaataa cttcaatttt tcccattttt ggaattcctt
    46021 ctttcaattt attcttctta ttataccaaa aaacggttta aaaatctttc taaaccattt
    46081 atttttgata atttttacat tagatcagcc tctttaagag ctgtctgtac tgtctcaagt
    46141 ggtaaatggg tcaattctgt ccctttttct tgataaaggt attgggcgta gtcgtccatt
    46201 cggtactggt tgatataaac cacacgcttg cagccgacct gaagcaattg ttttgtacag
    46261 ttgagacaag gaaaatgggt tacataggct gtaaagcctt tgggaacacc acgctcagca
    46321 ccttgaagga tagcattgac ctcagcgtga agggtgcgaa cacagtggcc ttcaatgacc
    46381 aaacattcgt gatcaataca atgctcagtc cctgacaccg aaccattgta accagtggaa
    46441 ataaccttat tatcttttac cagaatcgcg cccactttag cacgtttaca agtggaacga
    46501 ttcgcaatta gtagggcttg ggctgcaaaa tactcatccc aggccagtct tttttcagtc
    46561 atctcttttc tcctttttct ctatttttta aaaaatggta aacctaaatc tgcaatcttt
    46621 tcagctggta ccttcatgcc atccttgatc cattttagaa ggacagagac aatggctgag
    46681 ctccagaagg aatgaagata agagctgaca ccttttgatt tcccatggta tttttctaga
    46741 aattcctgca tggcttggac aaagattttt tccagatggt aatccaaggc caattgaatc
    46801 actctagctt cctttctggc ctcccggaaa aggtgaaccc aaaccaaata aaggtctgtc
    46861 tttaaatcgt aatgatgcag ctgttccata atattgtgga cagttcgttt aaagacgctc
    46921 tctaaaattt cctctttgga gtcataattg cgataaaagg ccgcacgcga aacacctgca
    46981 cgtttgacca attcagaaat actaatcttg gtcagctcct ttttttccaa gagttgcaag
    47041 agggctgttt caatggcttc tctggttaat aaattggatt cttggtttga ttttctgaga
    47101 ttttcaagag acttttcaga gattctacgt tcagacataa cattttcttt ctacttgtca
    47161 caacagacgg atgatgcttt tgtttcaaga gttttcatga tataattgta aaaaaagaca
    47221 gaacctttgt caatgtataa ctgacaaaga tggagaattt ctatgacttg gaaaattatt
    47281 gctgactctg gttgtgatta tcgtcaactg ccaacaccag ctattaacac aacctttgta
    47341 agtgtcccct taaccattca agtagctgat caggtctttg ttgatgacgc cagtctcgat
    47401 attgaccaaa tgatggaaac catgtatgca actgcagaag cttcaaaatc ggcttgtcca
    47461 agcccagatg actatttgcg agcatttgaa ggtgccaaaa acattttcct agtaaccatc
    47521 acaggtaccc tttctggcag tcacaatagt gctcaactag caaagaatat ttatctggaa
    47581 gaccatcctg acactaagat tcatgtgatt gatagtttat ctgctggtgg tgaagttgac
    47641 ctactcgtag aaaaattgaa tgacttgatt gaccagggct tgtcttttga agaagtggtt
    47701 gaagctatca ccgcctatca agaaaaaact aagttgctct ttgtcctagc caaagtcgat
    47761 aacttggtga agaacggccg tttgagcaag cttatcggta cggtcgttgg ccttctcaac
    47821 attcgtatgg tcggaaaagc tagtgaaact ggaactctcg aattgctaca aaaagcaagg
    47881 ggatcaaaga aatcagttca agctgcctat gatgagttag taaaagctgg atatgctggt
    47941 ggccgtattg tcatggccca acgcaataac gaaaaatgtt gtcaacagct ctcagagcga
    48001 atccgtgaaa ccttcccaca agcggatatt aaaattctac caacctctgg tctctgcagt
    48061 ttctatgcag aagagggcgg tttgctgatg ggctatgaaa ttgattaatt gcattcttga
    48121 caagaggtga ccatcatctc ttgttttttt gtggtacaat agagctatga aacattttga
    48181 tactattgtc atcggtgggg gacctgctgg tatgatggct acgatttcca gtagctttta
    48241 tggacagaaa accctcctca tcgaaaaaaa tcggaaactt ggaaaaaaat tagctgggac
    48301 tggtggggga cgttgcaatg tgaccaacaa tggtagctta gacaacctgc tagctggaat
    48361 tcctggaaac ggacgctttc tttacagtgt tttctcccag ttcgataatc atgacatcat
    48421 caactttttt acagaaaatg gtgttaaact taaggtcgaa gaccacggac gcgtctttcc
    48481 agccagtgac aagtctcgga ctattatcga agctttggaa aagaaaatca ctgaactagg
    48541 tggtcaagtt gctactcaaa tagaaatcgt ttctgttaaa aaagtagatg accagtttgt
    48601 ccttaagtca gcggatcaaa ccttcacttg tgagaaactc attgtcacaa caggtggtaa
    48661 gtcttatcct tcgactggtt cgactggttt tggtcacgag attgctcgcc attttaagca
    48721 taccatcacc gatcttgagg ctgctgaaag tcctttatta acagattttc cacataaagc
    48781 cttacaaggg atttctctgg acgatgtgac cctaagttat ggtaagcatg tcatcactca
    48841 tgatttactc tttacccact ttggtttgtc aggtcctgct gccctacgca tgtctagctt
    48901 tgtcaaaggt ggggaggttc tctcactcga tgttttgcct caactttctg agaaggactt
    48961 ggttacattt ctagaagaaa atcgggaaaa atccttgaaa aacgctttaa aaaccttgtt
    49021 accagaacgc ttggccgaat tttttgtaca aggatatcct gaaaaagtca aacagctgac
    49081 tgaaaaggaa cgagaacagc ttgtccagtc cattaaagaa cttaaaattc ctgtaactgg
    49141 aaaaatgtcc cttgcaaagt cctttgttac caagggtgga gtcagtctca aggaaatcaa
    49201 tcctaaaacc cttgaaagta agctggtacc tggcctccac tttgcaggcg aagttatgga
    49261 tatcaatgcc cacacgggtg gctttaacat cacttctgcc ctctgtaccg gctgggtggc
    49321 gggaagtctg cattatgatt aaagattaaa ggttgtgaag aatgaacaga agagaggcag
    49381 tcgaatttgt taacatgtgt atgattaaaa acggagataa ggtcctggtc caagaccgag
    49441 ttagtcccga ctggcctggc attacttttc ctggtggtca tgttgaacgt ggcgaatcct
    49501 ttgtcgatgc tgtcattcgt gaagtgaaag aagaaactgg tctgatcatt tccaaacccc
    49561 aactctgtgg tatcaaaaac tggtatgacg acaaggatta tcgttatgtc gtcctttttt
    49621 acaagacaga acactttact ggtgaactcc agtcttcaga cgaagggaaa gtttggtggg
    49681 aggactttga aaatctttct catctaaaac ttgcaaccga tgatatgtct gatatgcttc
    49741 gtgtgtttct agaagaagat ctcagtgaat tcttttacta caaaaacggt gacgactggc
    49801 tttatgattt gaagtaaaaa ataggctagg aaattcctag cctatttttt ctgcatttgt
    49861 ctgaacgtaa gctgcaatgg catctgacgt gtactgggct gttccagaac caaacttgtc
    49921 aatgttttcc ttaaactctg ggttatagac gtaaccttta ccgatatgac cgaatacctc
    49981 aatagagcag tcaaatccat aagtgcgaat ggcttgcaag agcttggctg cttgctcttg
    50041 gttttcggtt gctgttgcag gtaaaccaac ttgaagattt tgtgccaaag tttgaaagac
    50101 ttggttaaag gcggccgtag cctcgtcttc gtgacctttt tggcgttcga gcgcttgtcc
    50161 catgacttct tgaccatatt tctctaccgc ttcttggtgg tatttttgat tgtcttgata
    50221 gctaaatccc gtgaattttt cctcaatggt catttttctt tctccttttt gttcttgaat
    50281 agttttttgc aaggtggaaa tcaaggtatc cagatgttgc ctttcgcgag ttagatagtc
    50341 caactgccta gtcaaatggg gcaataaatc tgtcctttct tcctttaaca gctctgctat
    50401 tttctctaaa gaaaagccta gatatttgta gtaaagaatg acctgaaggc gttccaaatc
    50461 ctcttgactg taggttcgat agccgttttc cgactttaag gggaccaaga gtcctatctt
    50521 gtcatagtga tgcagggtct tgacagagat acctgaaagc tgcgcagctt cttttatatg
    50581 gtacatgatt tcctccttac aatgatagta taacccctcc ccttaggtca gagtcaagcg
    50641 tttttgagaa aattttttaa cttttttgag aaaggtgtga aaacttgaaa atgattttct
    50701 tgacagacct tagaaaacat gataggatag tcaagtctat caatcaaaca gaaggctatt
    50761 tgacaactca agtagctttt tcttattttg aaaaaggaga tcagagttta actatgtcag
    50821 aaaaatcaca atgggggtcg aaacttggtt ttattctagc atctgctggc tggccatcgg
    50881 gcttggtgcc gtttggaagt ttccctacat gactgctgct aatggcggtg gaggcttttt
    50941 actaatcttt ctcatttcca ctattttaat cgatttccct ctcctgctgg ctgagtttgc
    51001 ccttggccgt agtgctggcg tttccgctat caaaaccttt ggaaaactgg gcaagaataa
    51061 caagtacaac tttatcggtt ggattggcgc ctttgccctc tttatcctct tatcttttta
    51121 cagtgttatc ggaggatgga ttctagtcta tctaggtatt gagtttggga aattgttcca
    51181 acttggtgga acgggtgatt atgctcagtt atttacttca atcatttcaa atccagccat
    51241 tgccctagga gctcaagcgg cctttatcct attgaatatc ttcattgtat cacgtggggt
    51301 tcaaaaaggg attgaaagag cttcgaaagt catgatgccc ctgctcttta tcatctttgt
    51361 tgttatcatc ggtcactctc tcagcttgtc aaatgccatg gaaggggttc tttacttcct
    51421 caaaccagac ttttcaaaac tgactagcgc tgatctcctc tatgctctgg gacaatcttt
    51481 ctttgccctc tcactagggg ttacagtcat gttgacctat gcttcttact tggacaagaa
    51541 aaccaatcta gtccagtcag gaatctccat cgtagccatg aatatctcga tatccatcat
    51601 ggcaggtcta gccattttcc cagccatgtc agccttcaat atccagtctg aagggggacc
    51661 gagcttgctc tttatcgtct tgcctcaact ttttgacaag atgccttttg gaaccatttt
    51721 ctacgtcctt ttcctctttg cgactgtcac ttcttctgtc gtgatgctgg agatcaatgt
    51781 gggcaatatc accaaccagg ataacagcaa acgtgccaaa tggagtgtta ttttaggaat
    51841 tttgaccttt gtctttggca ttccttcagc cctatcttac ggtgtcatgg cggatgttca
    51901 catttttggt aagatcttct ttgacgctat ggacttcttg gcttccaatc tcctcatgcc
    51961 atttggagct ctctaccttt cactttttac aggctatatc tttaaaaagg ctcttgcaat
    52021 ggaggaactc catctcgatg aaagagcatg gaaacaagga ctgttccaag tctggctctt
    52081 ccttcttcgt ttcttcgttt cgtcattcca atcatcatca ttgtggtctt cattgcccaa
    52141 tttatgtaat caaaaaggac ttgagtagtg aactcaggcc ctttcttttt atggatggct
    52201 aacaatcaat tccaaatctt gcccttctag agtccaagat tcaacatcac ttggtaggat
    52261 aaagtgtctc cctttttgga ttggatagtt tttcccgtca acagttagtt gaccttgacc
    52321 agccaagaca ctcaacaagc tgtagtcagc tgtcttttca aagttaactt ttccagtaat
    52381 ttcccatttg taaactgcga agaaatcatt ggatacaagg agagtggaac gtagatcatc
    52441 tgctttgatt gtcactggac ggctatttgc gggttcacca atgttcaaga catcgataga
    52501 tttttcaagg tgaagttcac gtaaattgcc cttgtcatcc ttacggtcaa agtcatagac
    52561 acggtaagtg gtatcgctag actgctgggt ttcaagaatc aagatacccg ccccgatagc
    52621 gtgcatggta ccgcttggta catagaagaa atctcctgct ttaactggca cttttgtcaa
    52681 cagcgcatcc cagttcttat cctcgatttg ctggcggagt tcttcttttg acttggcatt
    52741 gtgaccgtag ataatctctg aaccttcatc tgctgcaatg atgtaccaac attctgtttt
    52801 tccaagttcg ccttcatgct cgagtccata agcatcgtct gggtgaactt ggacactgag
    52861 ccagtcgttg gcatcgagga tcttggtcaa aagtggaaat acaggctcag gacgattgcc
    52921 aaataattca cggtgttccg catacaaagt agcaagatct gttccctcgt aacgaccatt
    52981 ggcaacttta gaaacaccat ttagatgagc tgagatagcc cagtactctc cgactttttc
    53041 acttgggatg tcgtagccaa actcatcacg tagcttggta ccaccccaga ttttttcttg
    53101 cataactgat tgtaaaaata atggttctga catcttaatc tcctgtctga tttttctccc
    53161 ctcattatag caaaaaaaga gttccatttg aactcttttt tacatcttat aaagcaggga
    53221 gaagatttta taaaaatagt aaacaaatgt gctctactcg atgcttacac cattgctatc
    53281 aatgacatcc ttgtaccaat agaaggactt cttcttgcta cgtttgagag tcccatttcc
    53341 tacattatct cgatctacat agataaagcc atagcgctta ttcatttccc ctgtgccagc
    53401 tgaaaccgga tcgatacagc tccaagtcgt ataaccaagc aagtcaaccc cgtcttggta
    53461 aatggcatct cgcatggcct tgatgtgggc ctctaagtaa gtaatccgat agtcatctgc
    53521 tacataacca ttctcatccg gtgtatccat agcaccgagt ccattttcta cgataatact
    53581 aaactaaaat
//
LOCUS       DAVLHC010000009        50485 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.009, whole genome shotgun sequence.
ACCESSION   DAVLHC010000009 DAVLHC010000000
VERSION     DAVLHC010000009.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 50485)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 50485)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..50485
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.009"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            336..1382
                     /gene="pheS"
                     /locus_tag="VXE25_000563"
     CDS             336..1382
                     /gene="pheS"
                     /locus_tag="VXE25_000563"
                     /EC_number="6.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013903845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phenylalanine--tRNA ligase subunit alpha"
                     /protein_id="HEV0771078.1"
                     /translation="MSTIEEQLKALREETLASLKQITAGNEKEMQDLRVSVLGKKGSL
                     TEILKGMKDVSAEMRPIIGKHVNEARDVLTAAFEETAKLLEEKKVAAQLASESIDVTL
                     PGRPVATGHHHVLTQTSEEIEDIFIGMGYQVVDGFEVEQDYYNFERMNLPKDHPARDM
                     QDTFYITEEILLRTHTSPVQARAMDAHDFSKGPLKMISPGRVFRRDTDDATHSHQFHQ
                     IEGLVVGKNISMADLQGTLQLIVQKMFGEERQIRLRPSYFPFTEPSVEVDVSCFKCGG
                     EGCNVCKKTGWIEIMGAGMVHPRVLEMSGIDATVYSGFAFGLGQERVAMLRYGINDIR
                     GFYQGDVRFSEQFK"
     gene            1382..1891
                     /locus_tag="VXE25_000564"
     CDS             1382..1891
                     /locus_tag="VXE25_000564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0771079.1"
                     /translation="MIRKVEMADVEVLAKIAKQAFRETFAYDNTEEQLQEYFEEAYSL
                     KTLSTELGNPDSETYFIMHEEEIAGFLKVNWGSAQTERELEDAFEIQRLYVLQKFQGF
                     GLGKQLFEFALELATKNSFSWAWLGVWEHNTKAQAFYNRYGFEKFSQHHFMVGQKVDT
                     DWLLRKKLR"
     gene            1968..4373
                     /locus_tag="VXE25_000565"
     CDS             1968..4373
                     /locus_tag="VXE25_000565"
                     /EC_number="6.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002897790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phenylalanine--tRNA ligase subunit beta"
                     /protein_id="HEV0771080.1"
                     /translation="MLVSYKWLKELVGIDVPSQELAEKMSTTGIEVEGVESPAAGLSK
                     IVVGEILSCEDVPETHLHVCQVNVGEEEERQIVCGAPNVRAGIKVMVALPGARIADNY
                     KIKKGKIRGLESLGMICSLGELGISDSVVPKKFADGIQILPENAVPGEEVFSYLDLDD
                     EIIEFSITPNRADALSMRGVAHEVAAIYDKAVNFKEFTLTETNEAATDALSVGIETDK
                     APYYAARILDNVTIAPSPQWLQNLLMNEGIRPINNVVDVTNYILLYFGQPMHAFDLDT
                     FEGTDIRVREARAGEKLVTLDGEERDLDVNDLVITVADKPVALAGVMGGQATEISEKS
                     SHVVLEAAVFNGKSIRKTSGRLNLRSESSSRFEKGINVATVNEALDAAASLIAELAGA
                     TVRKGIVSAGELDTSDVEVSSTLADVNRVLGTELSYADVEDVFRRLGFGLSGNADSFT
                     VSVPRRRWDITIEADLFEEIARIYGYDRLPTSLPKDDGTAGELTVTQKLRRQVRTIAE
                     GAGLTEIITYALTTPEKAVEFTAQPSNLTELMWPMTVDRSVLRQNMISGILDTVAYNV
                     ARKNKNLALYEIGKVFEQTGNPKEELPNEINSFAFALTGLVAEKDFQTAAVPVDFFYA
                     KGILEALFTRLGLEVTYTATAEIASLHPGRTAVISLGDQVLGFLGQVHPVTAKAYDIP
                     ETYVAELNLSVIEAALQPAAPFVEITKFPAVSRDVSLLLKAAVTHQEVIDAIQAAGVK
                     RLTDIKLFDVFSGEKLGLGMKSMAYSLTFQNPEDSLTDEEVARYMEKIQASLEKKVNA
                     EVR"
     gene            complement(4546..5547)
                     /locus_tag="VXE25_000566"
     CDS             complement(4546..5547)
                     /locus_tag="VXE25_000566"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000597989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="HEV0771081.1"
                     /translation="MIKTFLSALSVILFVIPIITYSFFPSSNLNIWLSTRPILAQIYA
                     FPLATATMAAILSFVFFSLSFYKKNKQIRFYSGILLLLSLILLLFGTDKTLSSASNKT
                     KTLKLVTWNVANQIEAQHIERIFSHFDADMAIFPELATNIRGEQENQRIKLLFHQVGL
                     SMANYDIFTSPPTNSGIAPVTVIVKKSYGFYTEAKTFHTTRFGTIVLHSRKQNIPDII
                     ALHTAPPLPGLMEIWKQDLNIIHNQLASKYPKAIIAGDFNATMRHGALAKISSHRDAL
                     NVLPPFERGTWNSQSPKLFNATIDHILLPKNHYYVKDLDIVSFQNSDHRCIFTEITF"
     gene            5703..6106
                     /locus_tag="VXE25_000567"
                     /pseudo
     CDS             5703..6106
                     /locus_tag="VXE25_000567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001155321.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
     gene            6232..6498
                     /locus_tag="VXE25_000568"
     CDS             6232..6498
                     /locus_tag="VXE25_000568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEV0771082.1"
                     /translation="MEGCPSELFSKEEILESDMRVAIMSELIEARYEQGISQKKLEEV
                     SGISQPVIARMETGKTSPQLDTVLKVLASLGKTLAVVPLEQGKS"
     gene            6759..9008
                     /gene="metE"
                     /locus_tag="VXE25_000569"
     CDS             6759..9008
                     /gene="metE"
                     /locus_tag="VXE25_000569"
                     /EC_number="2.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009729869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-methyltetrahydropteroyltriglutamate--
                     homocysteine S-methyltransferase"
                     /protein_id="HEV0771083.1"
                     /translation="MSTTIIGFPRLGEFRELKFTTEKYFRKEISEEELLAAAKDLRAK
                     HWNIVKEKGITEIPSNDFSHYDNFLDAAFLFNVVPASVQNLDLSDLERYFALGRGYQG
                     EKGDVRALPMKKWFNTNYHYIVPKFEKDTQVKLAGHKIFDEFQEAKELGLNTRPVLVG
                     PFTFLQLSDFEEGVKADDFVDSLVSAYQEVFAKLAELGATRIQLDEAALVKDLTAEEK
                     ALFLNLYNKLLADKKGLEVLLQTYFGDVRDVYADLVNLPVDAIGLDFVEGKKTLELVK
                     GGFPADKTLYVGIVNGKNIWRNNYEKSLTVLEQIPAENIVLTSSCSLLHVPFTTANEE
                     FEPALLNHFAFAVEKLDEIRDLDAIRNGQGSEALAANKELFATERVGENAELRARIAG
                     LTDADYTRLPAFAEREAIQEEAFKLPALPTTTIGSFPQTKEVRAKRLAYRKGELSQKE
                     YDAFLAETIDEWIKWQEDIDFDVLVHGEFERNDMVEYFGQNLSGYLFSKNGWVQSYGM
                     RGVKPPIIWGDVTRLNPITVKWSSYAQSRTNKPVKGMLTGPVTILNWSFPREDISIKD
                     STLQIALAIKDEVLDLEAAGVKIIQIDEAALREKLPLRRSDWYEDYLDWAIPAFRLVH
                     STVAPDTQIHTHMCYSEFTDIIPAIDNMDADVISFEASRSNLEILDELKAKNFQTEVG
                     PGVYDIHSPRVPNEGEIDNTIEVILAKVPSKKVWINPDCGLKTRGIPETKESLIRLVE
                     AAKAAREKL"
     gene            9072..9938
                     /gene="metF"
                     /locus_tag="VXE25_000570"
     CDS             9072..9938
                     /gene="metF"
                     /locus_tag="VXE25_000570"
                     /EC_number="1.5.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000089969.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="HEV0771084.1"
                     /translation="MSRQTPSLSFEVFPPNPAVGNDNIISALQDMQELAPHFISVTAS
                     NNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALR
                     GDIIPDVEPQKDFRYATDLIEFIKEQTPHFDIIGACYPEGHPDSPNQISDIQNLKKKV
                     DAGCSSLVTQLFFDNERFYDFQDKCILAGIDVPIHAGIMPILNRNQALRLLKTCENIH
                     LPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNADTAKYIHQ
                     ATHALFNHQSLG"
     gene            10625..12838
                     /gene="pnp"
                     /locus_tag="VXE25_000571"
     CDS             10625..12838
                     /gene="pnp"
                     /locus_tag="VXE25_000571"
                     /EC_number="2.7.7.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001854499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyribonucleotide nucleotidyltransferase"
                     /protein_id="HEV0771085.1"
                     /translation="MAKQVFQTTFAGRELIVETGQVAKQANGSVVVRYGESTVLTAAV
                     MSKKMATGDFFPLQVNYEEKMYAAGKFPGGFMKREGRPSTDATLTARLIDRPIRPMFA
                     EGFRNEVQVINTVLSYDENASAPMAAMFGSSLALSISDIPFDGPIAGVQVGYVDGQII
                     INPSQEQAEQSLLELTVAGTKHAINMVESGAKELSEEIMLEALLKGHEAVKELIAFQE
                     EIVAAVGKEKAEVELLHVDAELQAEIIAAYNSDLQKAVQVEEKLAREAATQAVKDQVT
                     AVYEEKYANHEEFDRIMRDVAEILEQMEHAEVRRLITEDKVRPDGRKVDEIRPLDAVV
                     DFLPRVHGSGLFTRGQTQALSVLTLAPMGETQIIDGLDPEYKKRFMHHYNFPQYSVGE
                     TGRYGAPGRREIGHGALGERALAQVLPSLEEFPYAIRLVAEVLESNGSSSQASICAGT
                     LALMTGGVPIKAPVAGIAMGLISDGNNYTVLTDIQGLEDHFGDMDFKVAGTRDGITAL
                     QMDIKIQGITAEILTEALAQAKKARFEILDVIEATIPEVRPELAPTAPKIDTIKIDVD
                     KIKIVIGKGGETIDKIIAETGVKIDIDEEGNVSIYSSDQDAINRAKEIIAGLVREAKV
                     DEVYRAKVVRIEKFGAFVNLFDKTDALVHISEMAWTRTNRVEDLVEIGDEVDVKVIKI
                     DEKGRIDASMKALLPRPPKPEHDEKGEKSERPHRPRHHKDHKPKKEFTETPKDSE"
     gene            12854..13471
                     /gene="cysE"
                     /locus_tag="VXE25_000572"
     CDS             12854..13471
                     /gene="cysE"
                     /locus_tag="VXE25_000572"
                     /EC_number="2.3.1.30"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000539958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine O-acetyltransferase"
                     /protein_id="HEV0771086.1"
                     /translation="MGWWHETIDIVKENDPAARTTLEVLLTYPGVKALAAHRLSHFLW
                     KYDFKLLARMHSQFWRFWTQIEIHPGAQIDSGVFIDHGSGLVIGETAIVEKGVLLYHG
                     VTLGGTGKDCGKRHPTVRKGALISAHAQVIGPVEIGENAKVGAAAVVVADVPSDVTVV
                     GIPAKIVRLHGKKDEPVIHEVEEKREYYVNKLEQAKDASHRSSGL"
     gene            13483..14367
                     /locus_tag="VXE25_000573"
     CDS             13483..14367
                     /locus_tag="VXE25_000573"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000613615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0771087.1"
                     /translation="MIQARNKLSQEELSEAKKVINCCQNYDGTYRDPYLSNMLNFDPN
                     MPAFFLYYEKGKLVGLLTVYADDQDVEVTILVHPGHRRQGIARALFTSFERETASFPI
                     RSVTFQTERIFLENHPDFASNWGLIEDEETETWLGKDRRPYQLAKLSNLEVLLADSSY
                     QEQISQLKFQAFSGEHESREVVDRYVAEALKDPESRLYILLKDGQVIGTCTVDLSSDT
                     NYFYGLAISEPERGKGYGSYLAKSLVNQLIEQNDKEFQIAVEDSNVGAKRLYEKIGFV
                     KQTQVVYLNEKGARDSEV"
     gene            14454..15797
                     /locus_tag="VXE25_000574"
     CDS             14454..15797
                     /locus_tag="VXE25_000574"
                     /EC_number="6.1.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002916477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine--tRNA ligase"
                     /protein_id="HEV0771088.1"
                     /translation="MIKIYDTMSRDLREFVPIEDGKIKMYVCGPTVYNYIHVGNARST
                     VAFDTIRRYFEYRGYKVAYISNFTDVDDKIINRAREEGITPQEVADKYIAAFREDVTA
                     LGVKPATRHPRVVEFMADIIRFVEDLIEKGFAYESQGDVYFRVEKSHNYAKLANKTLE
                     DLELGASGRTDEETARKENPVDFALWKSSKPGEISWDSPWGPGRPGWHIECSVMSTEI
                     LGDTIDIHGGGADLEFPHHTNEIAQSEAKTGKAFANYWMHNGFVNIDNVKMSKSLGNF
                     ITVHDALKTLDGQVLRFFFATQHYRKPINFTEKAVRDAETNLKYLKNTYEQPFTGNVD
                     AQELQNFKDKFVAAMDEDFNAANGITVVFEMAKWINSGNYDASVKQALADMLEIFGIV
                     FVEEVLDAEIEDLIQKRQEARANRDFETADQIRDQLVTQGIKLLDTKDGVRWTRD"
     gene            15790..16176
                     /locus_tag="VXE25_000575"
     CDS             15790..16176
                     /locus_tag="VXE25_000575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006148900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mini-ribonuclease 3"
                     /protein_id="HEV0771089.1"
                     /translation="MIDVNLINGIALAFEGDAVYSMYIRRHLILKGMTKPNKLHQEAT
                     KYVSAKAQARLIALMLEEQVLTEKEEEIYKRGRNTNSHTKAKNADVVTYRMSTGFEAV
                     MGYLHMTENLERLESLVSWCIQKVEG"
     gene            16180..17064
                     /locus_tag="VXE25_000576"
     CDS             16180..17064
                     /locus_tag="VXE25_000576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PucR family transcriptional regulator"
                     /protein_id="HEV0771090.1"
                     /translation="MREKELQDWFPEARISDQPVEKEGYLTLPLASQQWILLEEAGLS
                     EREKQLVALLTQQEQARSLNPWYSYLVEGKGQAPQVFKKIQLVYCHLSYFQQENLASW
                     LDMMRTLFPNCQTVLQVGSQDYVFVLQQDKYTSVRDILSDTIEAVEYDFGLRLSIMLG
                     QVWSQTGHQALSDLIKAERDLFKTWWRQGHQGVHTFSQLYLWSMGERLVDLKPIKECL
                     HQMILDQDQIQEIILSLWENSAVLTKTAQQLYLHRNSLQYKIDKWEELTGLQLKELTD
                     LTLCYQLILGSLSTIVGL"
     gene            17201..17800
                     /locus_tag="VXE25_000577"
     CDS             17201..17800
                     /locus_tag="VXE25_000577"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001166174.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771091.1"
                     /translation="MQILCYFTITVVAKPNNSGEVHLDVSIEDNQGGSGHNFSSVSSS
                     SQTAKYEETGYNNNLSLYITIDKTSDATALLKLKLNNVDNQPATEVPSSGITVKLNTK
                     DNAGNWTSASNKKEITVKIVSAKPTYPDKILVKNPDNIKDTEKNAIIEKLKEANKNHP
                     AGAPTFAKGEGEHANDIVATYSDGTTYYVPLNDVTKYAR"
     gene            17943..18113
                     /locus_tag="VXE25_000578"
                     /pseudo
     CDS             17943..18113
                     /locus_tag="VXE25_000578"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000040325.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron reverse transcriptase/maturase"
     gene            18469..19746
                     /locus_tag="VXE25_000579"
     CDS             18469..19746
                     /locus_tag="VXE25_000579"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001068247.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEV0771092.1"
                     /translation="MNPIQRSWAYVSRKRLRSFILFLILLVLLAGISACLTLMKSNKT
                     VESNLYKSLNTSFSIKKIENGQTFKLSDLASVSKIKGLENVSPELETVAKLKDKEAVT
                     GEQSVERDDLSAADNNLVSLTALEDSSKDVTFTSSAFNLKEGRHLQKGDSKKILIHEE
                     LAKKNGLSLHDKIGLDAGQSESGKGQTVEFEIIGIFSGKKQEKFTGLSSDFSENQVFT
                     DYESSQTLLGNSEAQVSAARFYVENPKEMDGLMKQVENLALENQGYQVEKENKAFEQI
                     KDSVATFQTFLTIFLYGMLIAGAGALILVLSLWLRERVYEVGILLALGKGKSSIFLQF
                     CLEVVLVSLGALLPAFVAGNGITTYLLQTLLASGDQASLQDTLAKASSLSTSILSFAE
                     SYVFLVLLSCLSVALCFLFLFRKSPKEILSSIS"
     gene            19759..20406
                     /gene="vex2"
                     /locus_tag="VXE25_000580"
     CDS             19759..20406
                     /gene="vex2"
                     /locus_tag="VXE25_000580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000173730.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding subunit Vex2"
                     /protein_id="HEV0771093.1"
                     /translation="MTLLQLQDVTYRYKNTAEAVLYQINYNFEPGKFYSIIGESGAGK
                     STLLSLLAGLDSPVEGSILFQGEDIRKKGYSYHRMHHISLVFQNYNLIDYLSPLENIR
                     LVNKKASKNTLLELGLDESQIKRNVLQLSGGQQQRVAIARSLVSEAPVILADEPTGNL
                     DPKTAGDIVELLKSLAQKTGKCVIVVTHSKEVAQASDITLELKDKKLTETRNTSK"
     gene            20458..21837
                     /gene="vex3"
                     /locus_tag="VXE25_000581"
     CDS             20458..21837
                     /gene="vex3"
                     /locus_tag="VXE25_000581"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit Vex3"
                     /protein_id="HEV0771094.1"
                     /translation="MLHNAFAYVTRKFFKSIVIFLIILLMASLSLVGLSIKGATAKAS
                     QETFKNITNSFSMQINRRVNQGTPRGAGNIKGEDIKKITENKAIESYVKRINAIGDLT
                     GYDLIETPETKKNLTADRAKRFGSSLMITGVNDSSKEDKFVSGSYKLVEGEHLTNDDK
                     DKILLHKDLAAKHGWKVGDKVKLDSNIYDADNEKGAKETVEVTIKGLFDGHNKSAVTY
                     SQELYENTAITDIHTAAKLYGYTEDTAIYGDATFFVTADKNLDDVMKELNGISGINWK
                     SYTLVKSSSNYPALEQSISGMYKMANLLFWGSLSFSVLLLALLLSLWINARRKEVGIL
                     LSIGLKQASILGQFITESILIAIPALVSAYFLANYTARAIGNTVLANVTSGVAKQASK
                     AAQASNLGGGAEVDGFSKTLSSLDISIQTSDFIIIFVLALVLVVLVMALASSNLLRKQ
                     PKELLLDGE"
     gene            22017..22100
                     /gene="pep27"
                     /locus_tag="VXE25_000582"
     CDS             22017..22100
                     /gene="pep27"
                     /locus_tag="VXE25_000582"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_198523890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative autolysis signal peptide Pep27"
                     /protein_id="HEV0771095.1"
                     /translation="MRKEFHNVLSSDQLLTDKRPARDYNRK"
     gene            22149..22805
                     /gene="vncR"
                     /locus_tag="VXE25_000583"
     CDS             22149..22805
                     /gene="vncR"
                     /locus_tag="VXE25_000583"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000697958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor VncR"
                     /protein_id="HEV0771096.1"
                     /translation="MKILIVEDEEMIREGVSDYLTDCGYETIEAADGQEALEQFSSYE
                     VALVLLDIQMPKLNGLEVLAEIRKTSQVPVLMLTAFQDEEYKMSAFASLADGYLEKPF
                     SLSLLKVRVDAIFKRYYDTGRIFSYKDTKVDFESYSASLAGQEVPINAKELEILDYLV
                     KNEGRALTRSQIIDAVWKATDEVPFDRVIDVYIKELRKKLDLDCILTVRNVGYKLERK
                     "
     gene            22802..24130
                     /gene="vncS"
                     /locus_tag="VXE25_000584"
     CDS             22802..24130
                     /gene="vncS"
                     /locus_tag="VXE25_000584"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase VncS"
                     /protein_id="HEV0771097.1"
                     /translation="MKRTGLFAKIFIYTFSIFSVLVICLHLAIYFLFPSTYLSHRQET
                     IGQKATAIAQSLEGKDRQSIEQVLDLYSQTSDIKGTVKGEMTEDKLEVKDSLPLDTDR
                     QTTSLFIEEREVKTQDGGTMILQFLASMDLQKEAEQISLQFLPYTLLASFLISLLVAY
                     IYARTIVAPILEIKRVTRRMMDLDSQVRLRVDSKDEIGNLKEQINSLYQHLLTVIADL
                     HEKNEAILQLEKMKVEFLRGASHELKTPLASLKILIENMRENIGRYKDRDQYLGVALG
                     IVDELNHHVLQILSLSSVQELRDDRETIDLLQMTQNLVKDYALLAKERELQIDNSLTH
                     QQAYLNPSVMKLILSNLISNAIKHSVPGGLVRIGEREGELFIENSCSSEEQEKLAQSF
                     SDNASRKVKGSGMGLFVVKSLLEHEKLAYRFEMEENRLTFFIDFPKVAQD"
     gene            24271..25152
                     /locus_tag="VXE25_000585"
     CDS             24271..25152
                     /locus_tag="VXE25_000585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001018994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-bisphosphate aldolase"
                     /protein_id="HEV0771098.1"
                     /translation="MAIVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAP
                     VLIQTSMGAAKYMGGYKVARNLIANLVESMGITVPVAIHLDHGHYEDALECIEVGYTS
                     IMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIGGEEDGIIGKGELAPIEDAK
                     AMVETGIDFLAAGIGNIHGPYPVNWEGLDLDHLQKLTEALPGFPIVLHGGSGIPDEQI
                     QAAIKLGVAKVNVNTECQIAFANATRKFARDYEANEAEYDKKKLFDPRKFLADGVKAI
                     QASVEERIDVFGSEGKA"
     gene            complement(25473..26663)
                     /locus_tag="VXE25_000586"
     CDS             complement(25473..26663)
                     /locus_tag="VXE25_000586"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000835812.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferric reductase-like transmembrane
                     domain-containing protein"
                     /protein_id="HEV0771099.1"
                     /translation="MKSVKGLLFIIASFILTLLTWMNTSPQFMIPGLALTSLSLTFIL
                     ATRLPLLESWFHGLEKVYTVHKFTAFLSIILLIFHNFSMGGLWGSRLAAQFGNLAIYI
                     FAGIILVAYLGKYIQYEAWRWIHRLVYLAYILGLFHIYMIMGNRLLTFNLLSFLVGSY
                     ALLGLLAGFYIIFLYQKISFPYLGKITHLKRLNHDTREIQIHLSRPFNYQSGQFAFLK
                     IFQEGFESAPHPFSISGGHGQTLYFTVKNSGDHTKNIYDNLQAGSKVTLDRAYGHMII
                     EEGRENQVWIAGGIGITPFISYIREHPILDKRVHFYYSFRGEENAVYLDLLRDYAQKN
                     PNFELHLIDSTKDGYLNFEQKEVPEHATVYMCGPISMMKALAKQIKKQNPKTELIYEG
                     FKFK"
     gene            complement(26868..27257)
                     /locus_tag="VXE25_000587"
     CDS             complement(26868..27257)
                     /locus_tag="VXE25_000587"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000131131.1"
                     /note="The N-terminal region of this protein, as described
                     by TIGR01726, is a three transmembrane segment that
                     identifies a subfamily of ABC transporter permease
                     subunits, which specificities that include histidine,
                     arginine, glutamine, glutamate, L-cystine (sic), the
                     opines (in Agrobacterium) octopine and nopaline, etc;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit"
                     /protein_id="HEV0771100.1"
                     /translation="MTDLSSWTAYFQDFGQFFNGFLFTLALAIGSFILAMVLGVFFGA
                     MSTSKRPILRILARIFVEFYQNTPLLVQFVIVFYGLPLISDHTIMIPIYWTAVLCVGL
                     YHGAYIAEVIRSGIQSLHPDCPHLLQL"
     gene            complement(27270..28034)
                     /locus_tag="VXE25_000588"
     CDS             complement(27270..28034)
                     /locus_tag="VXE25_000588"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000624332.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HEV0771101.1"
                     /translation="MISLFGLAAAKPVQADTSIADIQKRGELVVGVKQDVPNFGYKDP
                     KTGTYSGIETDLAKMVADELKVKIRYVPVTAQTRGPLLDNEQVDMDIATFTITDERKK
                     LYNFTSPYYTDASGFLVNKSAKIKKIEDLNGKTIGVAQGSITQRLITELGKKKGLKFK
                     FVELGSYPELITSLHAHRIDTFSVDRSILSGYTSKRTALLDDSFKPSDYGIVTKKSNT
                     ELNDYLDTLVTKWSKDGSLQKLYDRYKLKPSSHTAD"
     gene            complement(28074..28832)
                     /locus_tag="VXE25_000589"
     CDS             complement(28074..28832)
                     /locus_tag="VXE25_000589"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEV0771102.1"
                     /translation="MALVEFKNVEKYYGDYHALRNINLRFEKGQVVVLLGPSGSGKST
                     LIRTINGLEAVDKGSLLVNGHQVAGASQKDLVPLRKEVGMVFQHFNLYPHKTVLENVT
                     LSPIKVLGIDKKEAEKTAQKYLEFVNMWDKKDSYPAMLSGGQKQRIAIARGLAMHPEL
                     LLFDEPTSALDPETIGDVLAVMQKLAHDGMNMIIVTHEMGFAREVADRIIFMADGEVL
                     VDTTDVDNFFDNPSEARAQQFLSKIINHESDKVK"
     gene            29108..31330
                     /gene="recJ"
                     /locus_tag="VXE25_000590"
     CDS             29108..31330
                     /gene="recJ"
                     /locus_tag="VXE25_000590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001832038.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded-DNA-specific exonuclease RecJ"
                     /protein_id="HEV0771103.1"
                     /translation="MITPTYEWQFALQVEDADFTKIAKKAGLGPEVARLLFERGIQDQ
                     ESLKKFLEPSLEDLHDAYLLHDMDKAVERIRQAIEEGENILVYGDYDADGMTSASIVK
                     ESLEQLGAECRVYLPNRFTDGYGPNASVYKYFIEQEGISLIVTVDNGVAGHEAIALAQ
                     SMGVDVIVTDHHSMPETLPDAYAIVHPEHPDADYPFKYLAGCGVAFKLACALLEEVQV
                     ELLDLVAIGTIADMVSLTDENRILVQYGLEMLGHTQRIGLQEMLDMAGIAANEVTEET
                     VGFQIAPRLNALGRLDDPNPAIDLLTGFDDEEAHEIALMIHQKNEERKEIVQSIYEEA
                     KTMVDPEKKVQVLAKEGWNPGVLGIVAGRLLEELGQTVIVLNIEDGRAKGSARSVEAV
                     DIFEALDPYRDLFIAFGGHAGAAGMTLEVEQLSDLSQVLEDYVREKGADAGGKNKLNL
                     DEELDLEALSLETVKSFERLAPFGMDNQKPIFYIKNFQVESARTMGAGNAHLKLKISK
                     GEASFEVVAFGQGRWATEFSQTKNLELAVKLSVNQWNGQTALQLMMVDARVEGVQLFN
                     IRGKNAVLPEGVPVLDFPGELPNLAASEAVVVKNIPEDITQLKTIFQEQHFSAVYFKN
                     DIDKAYYLTGYGTRDQFAKLYKTIYQFPEFDIRYKLKDLAAYLNIQQILLVKMIQVFE
                     ELGFVTIKDGVMTVNKEAPKREIGESQIYQNLKQTVKDQEMMALGTVQEIYDFLMEKE
                     "
     gene            31505..33166
                     /locus_tag="VXE25_000591"
     CDS             31505..33166
                     /locus_tag="VXE25_000591"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease J"
                     /protein_id="HEV0771104.1"
                     /translation="MSNISLTTLGGVRENGKNMYIAEIGESIFVLNVGLKYPENEQLG
                     VDVVIPNMDYLFENSDRIAGVFLTHGHADAIGALPYLLAEAKVPVFGSELTIELAKLF
                     VKGNDAVKKFNDFHVIDENTEIDFGGTVVSFFPTTYSVPESLGIVLKTSEGSIVYTGD
                     FKFDQTASESYATDFARLAEIGRDGVLALLSDSANADSNIQVASESEVRDEITQTIAD
                     WEGRIIVAAVSSNLSRIQQIFDAADKTGRRIVLTGFDIENIVRTAIRLKKLSLANEIL
                     LIKPKDMSRFEDHELIILETGRMGEPINGLRKMSIGRHRYVEIKDGDLVYIATAPSIA
                     KEAFVARVENMIYQAGGVVKLITQSLHVSGHGNVRDLQLMINLLQPKYLFPVQGEYRE
                     LDAHAKAAMAVGMLPERIFIPKKGTTMSYENGDFVPAGSVSAGDILIDGNAIGDVGNV
                     VLRDRKVLSEDGIFIVAITVNRREKKIVARARVHTRGFVYLKKSRDILRESSELINQT
                     VEEYLQGDDFDWADLKGKVRDNLTKYLFDQTKRRPAILPVVMEAK"
     gene            33235..34014
                     /locus_tag="VXE25_000592"
     CDS             33235..34014
                     /locus_tag="VXE25_000592"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000290006.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="esterase family protein"
                     /protein_id="HEV0771105.1"
                     /translation="MAVMKIEYYSQVLDMEWGVNVLYPDANRVEEPECEDIPVLYLLH
                     GMSGNHNSWLKRTNVERLLRGTNLIVVMPNTSNGWYTDTQYGFDYYTALAEELPQVLK
                     RFFPNMTSKREKTFIAGLSMGGYGCFKLALTTNRFSHAASFSGALSFQNFSPESQNLG
                     SPAYWRGVFGEIRDWTTSPYSLESLAKKSDKKTKLWAWCGEQDFLYEANNLAVKNLKK
                     LGFDVTYSHSAGTHEWYYWEKQLEVFLTTLPIDFKLEERLT"
     gene            34126..35346
                     /gene="murM"
                     /locus_tag="VXE25_000593"
     CDS             34126..35346
                     /gene="murM"
                     /locus_tag="VXE25_000593"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001819885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan bridge formation alanyltransferase
                     MurM"
                     /protein_id="HEV0771106.1"
                     /translation="MYRYQIGIPTLEYDQFVKEHELANVLQSSAWEEVKSNWQHEKFG
                     VYREEKLLATASILIRTLPLGYKMFYIPRGPILDYGDKELLNFAIQSIKSYARSKRAV
                     FVTFDPSICLSQSLINQEKTEFPENLAIIDSLQQMGVRWSGKTEEMGDTIQPRIQAKI
                     YKENFEEDKLSKSTKQAIRTARNKGLEIQYGGLELLDSFSELMKKTEKRKEIHLRNEA
                     YYKKLLDNFKDKAYITLATLDVSKRSQELEEQLAKNRALEETFTESTRTSKVEAQKKE
                     KERLLEELTFLQEYIDVGQARVPLAATLSLEFGTTSVNIYAGMDDDFKRYNAPILTWY
                     ETARYAFERGMVWQNLGGVENSLNGGLYHFKEKFNPTIEEYLGEFTMSTHPLYPLLRL
                     ALDFRKTLRKKHRK"
     gene            35351..36583
                     /gene="murN"
                     /locus_tag="VXE25_000594"
     CDS             35351..36583
                     /gene="murN"
                     /locus_tag="VXE25_000594"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001229509.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan bridge formation alanyltransferase
                     MurN"
                     /protein_id="HEV0771107.1"
                     /translation="MALTTLTKEEFQTYSDQVSSRSFMQSVQMGDLLEKRGARIVYLA
                     LKQEGEIQVAALVYSLPMLGGLHMELNSGPIYTQQDALPVFYAELKEYAKQNGVLELL
                     VKPYETYQTFDSQGNPIDAEKKSIIQGLTDLGYQFDGLTTGYPGGEPDWLYYKDLTEL
                     TEKSLLKSFSKKGKPLVKKAETFGIRLKKLKREELSIFKNITKETSERREYSDKSLEY
                     YEHFYDTFGEQAEFLIASLNFSEYMSKLQGEQSKLEENLDKLRLDLSKNPHSEKKQNQ
                     LREYSSQFETFEVRKAEARDLIEKYGEEDIVLAGSLFVYMPQETTYLFSGSYTEFNKF
                     YAPALLQKYVMLESIKRGIPKYNFLGIQGIFDGSDGVLRFKQNFNGYIVRKAGTFRYH
                     PSPLKYKAIQLLKKIVGR"
     gene            36662..37363
                     /locus_tag="VXE25_000595"
     CDS             36662..37363
                     /locus_tag="VXE25_000595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001267193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="matrixin family metalloprotease"
                     /protein_id="HEV0771108.1"
                     /translation="MRWLFRLIGAFFSFVWRLFWRLVWIVVLLCVLAFGLLWYLNGDF
                     QGALKQAERSVKIGQQSIDQWEKTGQLPKLSQTDSHQHSEGRWAQASARIYLDPQMDS
                     RFQEAYLEAIQNWNQTGAFNFELVTESSKADITATEMNDGGTPVAGEAESQTNLLTGQ
                     FLSVTVRLNHYYLSNPYYGYSYERLVHTAEHELGHAIGLDHTDEKSVMQPAGSFYGIQ
                     EEDVANLRKIYETSE"
     gene            37403..39247
                     /gene="uvrC"
                     /locus_tag="VXE25_000596"
     CDS             37403..39247
                     /gene="uvrC"
                     /locus_tag="VXE25_000596"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001061148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrC"
                     /protein_id="HEV0771109.1"
                     /translation="MNNLIKSKLELLPTSPGCYIHKDKNGTIIYVGKAKNLRNRVRSY
                     FRGSHDTKTEALVSEIVDFEFIVTESNIEALLLEINLIKENKPKYNIMLKDDKSYPSI
                     KITNERYPRLIITRQVKKDGGLYFGPYPDVGAANEIKRLLDRIFPFRKCTNPPSKVCF
                     YYHIGQCMAHTICKKDETYFKSMAQEVSDFLKGQDNKIIDELKGKMAAAAQTMEFERA
                     AEYRDLIQAIGTLRTKQRVMAKDLQNRDVFGYYVDKGWMCVQVFFVRQGKLIERDVNL
                     FPYFNDPDEDFLTYVGQFYQEKSHLVPNEVLIPQDIDEEAVKALVDTKILKPQRGEKK
                     QLVNLAIKNARVSLEQKFNLLEKSVEKTQGAIENLGRLLQIPTPVRIESFDNSNIMGT
                     SPVSAMVVFVNGKPSKKDYRKYKIKTVVGPDDYASMREVIRRRYGRVQREALTPPDLI
                     VIDGGQGQVNIAKQVIQEELGLDIPIAGLQKNDKHQTHELLFGDPLEVVDLSRNSQEF
                     FLLQRIQDEVHRFAITFHRQLRSKNSFSSQLDGIDGLGPKRKQNLMRHFKSLTKIKEA
                     SVDEIVEVGVPRAVAEAVQRKLNPQGEALPQVAEERVDYQTEGNHNEP"
     gene            39237..40070
                     /locus_tag="VXE25_000597"
     CDS             39237..40070
                     /locus_tag="VXE25_000597"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001015777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase family protein"
                     /protein_id="HEV0771110.1"
                     /translation="MNHKIAILSDVHGNATALEAVIADAKNQGASEYWLLGDIFLPGP
                     GANDLVALLKDLPITASVRGNWDDCVLEVLDGQYGLENPQEIQLMRMTQFLMERMDPA
                     TTVWLRSLPLLEKKEIAGLRFSISHNLPNKNYGGDLLVENDTEKFDQLLDAETDVAVY
                     GHVHKQLLRYGSQGQQIINPGSIGMPYFNWEALKNHRAQYAVIEVEDGELVNIQFRKV
                     AYDYEAELELAKSKGLPFIEMYEELRRDDNYQGHNLELLASLIEKHGYVEDVKNFFDF
                     L"
     gene            complement(40252..41052)
                     /locus_tag="VXE25_000598"
     CDS             complement(40252..41052)
                     /locus_tag="VXE25_000598"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000714621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="HEV0771111.1"
                     /translation="MKKFSLLLAILPFLVACGNQATPKETSAQKTIVLATAGDVPPFD
                     YEDKGNLTGFDIEVLKAVDEKLSDYEIQFQRTAWESIFPGLDSGHYQAAANNLSYTKE
                     RAEKYLYSLPISNNPLVLVSNKKNPLTSLDQIAGKTTQEDTGTSNAQFINNWNQKHTD
                     NPATINFSGEDIGKRILDLANGEFDFLVFDKVSVQKIIKDRGLDLSVVDLPSADSPSN
                     YIIFSSDQKEFKEQFDKALKELYQDGTLEKLSNTYLGGSYLPDQSQLQ"
     gene            41223..41828
                     /locus_tag="VXE25_000599"
     CDS             41223..41828
                     /locus_tag="VXE25_000599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002924506.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HEV0771112.1"
                     /translation="MKFLELNKKRHATKHFTDKPVDPKDVRTAIEIATLAPSAHNSQP
                     WKFVVVREKNAELAKLAYGSNFEQVSSAPVTIALFTDTDLAKRARKIARVGGANNFSE
                     EQLQYFMKNLPAEFARYNEQQVSDYLALNAGLVAMNLVLALTDQGIGSNIILGFDKSK
                     VNEVLEIEDRFRPELLITVGYTDDKLEPSYRLPVDEIIEKR"
     gene            41841..43241
                     /gene="pepV"
                     /locus_tag="VXE25_000600"
     CDS             41841..43241
                     /gene="pepV"
                     /locus_tag="VXE25_000600"
                     /EC_number="3.4.13.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000125034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptidase PepV"
                     /protein_id="HEV0771113.1"
                     /translation="MIAIDFTAEVEKRKEDLLADLFSLLEINSERDDSKADAQHPFGP
                     GPVKALEKFLEIADRDGYPTKNVDNYAGHFEFGDGEEVLGIFAHMDVVPAGSGWDTDP
                     YTPTIKDGRLYARGASDDKGPTTACYYGLKIIKELGLPTSKKVRFIVGTDEESGWADM
                     DYYFEHVGLAKPDFGFSPDAEFPIINGEKGNITEYLHFAGENTGAARLHSFTGGLREN
                     MVPESATAVVSGDLADLQAKLDAFVAEHKLRGELQEEAGKYKVTIIGKSAHGAMPASG
                     VNGATYLALFLSQFGFAGPAKDYLDIAGKILLNDHEGENLKIAHVDEKMGALSMNAGV
                     FRFDETSADNTIALNIRYPKGTSPEQIKSILENLPVASVSLSEHGHTPHYVPMEDPLV
                     QTLLNVYEKQTGLQGHEQVIGGGTFGRLLERGVAYGAMFPDSIDTMHQANEFIALDDL
                     FRAAAIYAEAIYELIK"
     gene            43295..43873
                     /locus_tag="VXE25_000601"
     CDS             43295..43873
                     /locus_tag="VXE25_000601"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000078132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil-DNA glycosylase family protein"
                     /protein_id="HEV0771114.1"
                     /translation="MSQIERIKQAIMADSQNASYTERGIEPLFAAPKTARINIIGQAP
                     GLKTQEAGLYWKDKSGDRLRDWLGVDEDTFYNSGYFAVLPMDFYFPGHGKSGDLPPRT
                     GFAEKWHPQLLQELPDIQLTLLIGQYAQAYYLQEKISGKVTERVKHYKDYLPAYFPLV
                     HPSPRNQIWMAKNPWFEAEVVPDLKKRIKTIL"
     gene            44033..44185
                     /locus_tag="VXE25_000602"
     CDS             44033..44185
                     /locus_tag="VXE25_000602"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="HEV0771115.1"
                     /translation="MKEIAFDAFYQLYQNDQLSLVDVREVDEFAALHLEGAHNLPLSQ
                     LADSYD"
     gene            44228..44320
                     /locus_tag="VXE25_000603"
     CDS             44228..44320
                     /locus_tag="VXE25_000603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="HEV0771116.1"
                     /translation="MRSARACQFLLEQGYNVINVQGGMLAFEEL"
     gene            44491..45816
                     /gene="brnQ"
                     /locus_tag="VXE25_000604"
     CDS             44491..45816
                     /gene="brnQ"
                     /locus_tag="VXE25_000604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006152071.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid transport system II
                     carrier protein"
                     /protein_id="HEV0771117.1"
                     /translation="MAKKGTLTGLLLFGIFFGAGNLIFPPSLGALSGEHFLPAIAGFV
                     FSGVGIAVLTLIIGTLNPKGYIYEISTKIAPWFATLYLSVLYLSIGPFFATPRTATTA
                     YEVGISPLLSDANKGLGLIVFTVLYFAAAYLISLNPSKILDRIGRILTPVFAILIVIL
                     VVLGAIKYGGTSPQAASAAYQASAFGTGFLEGYNTLDALASVAFSVIAVQTLKQLGFS
                     SKKEYISTIWVVGIVVALAFSALYIGLGFLGNHFPVPAEAMKGGTPGVYILSQATQEI
                     FGSTAQLFLAAMVTVTCFTTTVGLIVSTAEFFNERFPQISYKVYATAFTLIGFAIANL
                     GLDAIIKYSIPVLVILYPITIAIVMIVIVNKFVALSKPGMQLTIAVVTVIAIASVLGS
                     SFKVEFLANLVSVLPFAKASLPWLVPAIVGILLSLVLPNKQESDVFEME"
     gene            45914..46951
                     /locus_tag="VXE25_000605"
     CDS             45914..46951
                     /locus_tag="VXE25_000605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001077203.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M42 family metallopeptidase"
                     /protein_id="HEV0771118.1"
                     /translation="MNQTVEYIKELTAIASPTGFTREISNYLVKTLEGFGYQPVRTAK
                     GGVNVTIKGQNDEQHRYVTAHVDTLGAIVRAVKPDGRLKLDRIGGFPWNMIEGENCTV
                     HVASTGQKVSGTILIHQTSCHVYKDAGTAERTQDNMEVRLDVKVSNEKETRALGIEVG
                     DFISFDPRTVVTDTGFIKSRHLDDKVSAAILLNLLRIYKKEKIELPVTTHFAFSVFEE
                     VGHGANSNIPAQVVEYLAVDMGAMGDGQQTDEYTVSICVKDASGPYHYDFRQHLVTLA
                     KEQNIPFKLDIYPFYGSDASAAMSAGAEVKHALLGAGIESSHSYERTHIDSVVATERM
                     VDAYIKSALVD"
     gene            46953..47423
                     /locus_tag="VXE25_000606"
     CDS             46953..47423
                     /locus_tag="VXE25_000606"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HIT family protein"
                     /protein_id="HEV0771119.1"
                     /translation="MCLICQRIELIKKGENPYFVKELETGYLVIGDHQYFAGYSLFLA
                     KEHVTELHHLEKETRLRFLEEMSLIQEAVAKAFTAEKMNIELLGNGDAHLHWHLFPRR
                     TGDMNGHGLKGRGPVWWVPFEEMTAETCQAKPDEIKRLVKRLSSEVDKLLEIKE"
     gene            47426..48142
                     /locus_tag="VXE25_000607"
     CDS             47426..48142
                     /locus_tag="VXE25_000607"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000747760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M15 family metallopeptidase"
                     /protein_id="HEV0771120.1"
                     /translation="MKKRYLVVTALLALSLAACSQEKAKNEDGTAKTEQTAKADGTVG
                     SKSQGAAQKKAEVVNKGDYYSIQGKYDEIIVANKHYPLSKDYNPGENPTAKAELVKLI
                     KAMQEAGFPISDHYSGFRSYETQTKLYQDYVNQDGKAAADRYSARPGYSEHQTGLAFD
                     VIGTDGDLVTEEKAAQWLLDHAADYGFVVRYLKGKEKETGYMAEEWHLRYVGKEAKEI
                     AASGLSLEEYYGFEGGDYVD"
     gene            complement(48182..48319)
                     /locus_tag="VXE25_000608"
     CDS             complement(48182..48319)
                     /locus_tag="VXE25_000608"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002674100.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771121.1"
                     /translation="MKIKEQTRKLAAGCSKYSFEVADKTDEVSSKHCFEVVNRTDAVS
                     R"
     gene            48451..48876
                     /gene="rplK"
                     /locus_tag="VXE25_000609"
     CDS             48451..48876
                     /gene="rplK"
                     /locus_tag="VXE25_000609"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004226069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L11"
                     /protein_id="HEV0771122.1"
                     /translation="MAKKVEKLVKLQIPAGKATPAPPVGPALGQAGINIMGFTKEFNA
                     RTADQAGMIIPVVISVYEDKSFTFVTKTPPAAVLLKKAAGVEKGSGTPNKTKVATVTR
                     AQVQEIAETKMPDLNAANVESAMRMIEGTARSMGFTVVD"
     gene            49084..49773
                     /gene="rplA"
                     /locus_tag="VXE25_000610"
     CDS             49084..49773
                     /gene="rplA"
                     /locus_tag="VXE25_000610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145049.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L1"
                     /protein_id="HEV0771123.1"
                     /translation="MAKKSKQLRAALEKIDSTKAYSVEEAVALAKETNFAKFDATVEV
                     AYNLNIDVKKADQQIRGAMVLPNGTGKTSRVLVFARGAKAEEAKAAGADFVGEDDLVA
                     KINDGWLDFDVVIATPDMMALVGRLGRVLGPRNLMPNPKTGTVTMDVAKAVEESKGGK
                     ITYRADRAGNVQAIIGKVSFEAEKLVENFKAFNETIQKAKPATAKGTYVTNLTITTTQ
                     GVGIKVDVNSL"
     gene            50151..50288
                     /locus_tag="VXE25_000611"
                     /pseudo
     CDS             50151..50288
                     /locus_tag="VXE25_000611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000040325.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron reverse transcriptase/maturase"
BASE COUNT        15199 a         9555 c        11482 g        14249 t
ORIGIN      
        1 tgttttcatc ttatttcaat ccgctataaa gttagataag aataagctaa caagcagaag
       61 taagataggt cttgcaagaa tggtaaaaat ctgataaact aagtagtaat tgaataggaa
      121 tctgaaagac tagtagccca agggaagtat atcagggagg agagccgtga ctgcaagctc
      181 tctatatgaa agctgggtga attcacttgc gcatggattt agaaatgaag gtctgacttg
      241 tcagatgaaa acggatggta ccgcgtgtca acgctccgag tggagttttt ggcatgtggt
      301 tttcttttta tctacgagag actgatggag gaaatatgtc aactattgaa gaacaattaa
      361 aagcgcttcg cgaagaaacg ctggctagct tgaagcagat tactgctgga aatgaaaaag
      421 agatgcaaga tttgcgtgtc tctgtccttg gtaaaaaggg ttcgctcact gaaatcctca
      481 aagggatgaa agatgtttct gctgagatgc gtccaatcat cgggaaacac gtcaatgaag
      541 ctcgtgatgt cttgactgct gcttttgaag aaacagctaa gctcttggaa gaaaagaaag
      601 tcgcggctca actggctagc gagagtatcg atgtgacgct tccaggtcgt ccagttgcga
      661 ctggtcacca tcacgttttg acacaaacca gtgaagaaat cgaagatatc ttcatcggta
      721 tgggttatca agtcgtggat ggttttgaag tggagcaaga ctactataac tttgaacgta
      781 tgaaccttcc aaaagaccac ccagctcgtg atatgcagga tactttctat atcactgaag
      841 aaatcttgct ccgtacccac acgtctccag ttcaggcgcg tgctatggat gcccatgatt
      901 tttctaaagg tcctttgaag atgatctcgc cagggcgtgt cttccgtcgc gatacggacg
      961 atgcgaccca cagtcaccaa ttccaccaaa tcgaaggctt ggtagttggg aaaaatatct
     1021 ctatggctga tcttcaagga acgcttcagt tgattgtcca aaaaatgttt ggtgaagagc
     1081 gtcaaattcg tttgcgtcca tcttactttc cattcacaga gccatctgtt gaggtggatg
     1141 tttcttgctt caaatgtggt ggagaaggct gtaacgtatg taagaaaaca ggttggatcg
     1201 aaattatggg ggccggtatg gttcacccac gtgtccttga aatgagtggt atcgatgcga
     1261 ctgtatactc tggctttgcc tttggtcttg gacaagagcg tgtagctatg ctccgttatg
     1321 gaatcaacga tatccgtgga ttctaccaag gagatgtccg cttctcagaa cagtttaaat
     1381 aatgattaga aaagtagaaa tggcagatgt tgaggtgttg gctaaaattg ccaaacaagc
     1441 ctttcgtgaa acctttgcgt atgataatac ggaagagcag ttacaggaat actttgaaga
     1501 ggcttatagt ctgaaaactt tgtcaactga gttgggaaat cctgactctg aaacctattt
     1561 cattatgcat gaggaggaga tagctggttt tctcaaagtc aactggggaa gtgctcaaac
     1621 tgagagagaa ttagaggacg cttttgaaat tcaacgcctc tatgtgctac aaaaattcca
     1681 aggatttgga ctaggtaagc aactgtttga attcgcactt gaacttgcta caaaaaatag
     1741 tttttcttgg gcttggctag gtgtttggga gcataataca aaagctcaag cgttttataa
     1801 ccgatatggt tttgaaaaat ttagccaaca tcattttatg gttggtcaaa aagtagatac
     1861 ggattggtta ctgagaaaga aattaaggta agaagagaat tcttctattg aaatgatagg
     1921 aaaggaaaag aaccagtgtg gcaatggtca ttctggagaa ctaaattatg cttgtatctt
     1981 ataaatggtt aaaagaattg gtgggcattg atgtgccatc acaggagttg gctgaaaaaa
     2041 tgtcaaccac agggatcgag gtcgaaggtg tcgaatcacc agctgccggt ctttcaaaaa
     2101 ttgtcgtcgg tgagatcttg tcctgcgaag atgtgccaga aactcacctt catgtttgtc
     2161 aggttaacgt tggcgaagaa gaagagcgtc agatcgtttg tggtgcccca aatgtgcgtg
     2221 caggcatcaa ggttatggtg gctcttccgg gagctcgtat cgctgacaat tacaaaatca
     2281 aaaaaggaaa aatccgtggc ttagagtcac ttggaatgat ctgttcactt ggtgaattgg
     2341 gtatttctga ctcagttgta cctaagaaat tcgcagatgg tattcaaatt ttgccagaaa
     2401 atgccgttcc aggtgaggaa gtcttttcat atctagactt ggatgatgaa atcatcgaat
     2461 tttctatcac accaaaccgt gcagatgccc tttctatgcg tggagtggct cacgaagtgg
     2521 cagccatata tgacaaggca gtcaacttta aagaatttac tttgacagaa acaaatgaag
     2581 ctgcgacaga tgccctttct gtgggcattg agacagacaa ggcgccttac tatgcagctc
     2641 gtatcttgga caatgtgact atcgcaccaa gtccacaatg gttgcaaaac cttctcatga
     2701 acgaaggcat ccgtcccatc aataacgttg tagacgtgac aaactacatc ctgctctact
     2761 ttggtcaacc tatgcatgct tttgacttgg acacatttga agggactgac atccgtgtgc
     2821 gtgaagcgcg tgctggtgaa aaattggtga ccttggacgg tgaagaacgt gacttggacg
     2881 tgaatgacct agtcatcact gttgcagaca agccagtagc ccttgcaggt gtcatgggtg
     2941 gtcaagcaac agaaatctct gaaaaatcta gtcatgttgt ccttgaagct gctgttttca
     3001 atggcaaatc tatccgtaag acaagtggtc gcctgaacct tcgttctgag tcatcttctc
     3061 gctttgaaaa aggaattaat gtggcaacag ttaatgaagc ccttgatgcg gcagctagcc
     3121 tgattgcgga acttgcaggt gcgacggtgc gtaagggtat cgtttcagcg ggtgagcttg
     3181 atacttcaga tgtagaagtt tcttcaactc ttgctgatgt taaccgtgtc ctcggaactg
     3241 agctgtctta tgctgatgtc gaagacgtct tccgtcgtct tggctttggt ctttctggaa
     3301 atgcagacag ctttacagtc agcgtaccac gtcgtcgttg ggatatcaca atcgaagctg
     3361 atctctttga agaaatcgct cgtatctatg gatatgaccg cttgccaacc agccttccaa
     3421 aagacgatgg tacagctggt gaattgactg tgacacaaaa actccgccgt caagttcgta
     3481 ccattgctga aggagcaggt ttgacagaaa tcatcaccta tgctctaaca actcctgaaa
     3541 aagcagttga gtttacggct caaccaagta accttacgga actcatgtgg ccaatgactg
     3601 tggatcgttc agtcctccgt caaaatatga tttcaggtat ccttgatacc gttgcctaca
     3661 acgtggctcg taagaataaa aacttggccc tttacgagat tggaaaagtc tttgaacaaa
     3721 caggtaatcc aaaagaagaa cttccaaatg aaatcaacag ttttgccttt gccttgacag
     3781 gcttggttgc tgaaaaagat ttccaaacag cagcagttcc agttgatttc ttctatgcta
     3841 aaggaatcct agaagcgctc tttactcgct tgggactaga agtgacctat acagcaacag
     3901 ctgagattgc cagccttcac ccaggacgta cagcagtcat ttcactcggt gaccaagttc
     3961 ttggttttct tggccaagtg catccagtca ctgctaaggc ttacgatatt ccagaaacgt
     4021 atgtggctga gctcaacctt tcagtcatcg aagctgccct tcaacctgct gctccatttg
     4081 tggaaatcac gaaattccca gcagtcagcc gtgacgtttc ccttctcctc aaggcagcag
     4141 taactcacca agaagttata gatgctatcc aagctgccgg cgtgaaacgt ttgacagata
     4201 tcaaactctt tgacgttttc tcaggtgaga aattgggact tggtatgaag tcaatggctt
     4261 atagcttgac cttccaaaat ccagaagaca gcttaacgga cgaagaagtc gcacgctaca
     4321 tggaaaaaat ccaagcatcg cttgaaaaaa aagtgaacgc agaagtgcgt taaacgatag
     4381 taggatacaa attccccctc tagtttatga acactagagg ggtgatttta tataatactc
     4441 aatgaaaatc aaaaagcaaa ctaggaagct agccgtaagc tgtacttgag tactgtaagg
     4501 cgaggctgac gtggtttgaa gagattgtcg aagagtataa aataattaaa atgtgatttc
     4561 tgtaaaaata catctatgat cagagttttg aaaacttaca atgtctaaat ctttaacata
     4621 gtagtggttt ttaggcaata aaatatgatc tattgttgca ttaaaaagtt ttggactttg
     4681 gctattccaa gttcctcttt caaaaggtgg tagtacattt aatgcgtccc tatgagagct
     4741 tatttttgca agtgctccat gacgcatagt tgcattaaaa tcacctgcaa taatagcctt
     4801 tggatatttt gaagccaatt gattatgaat gatgtttaag tcttgcttcc agatttccat
     4861 taaacctggc agaggaggag cagtatgcaa ggcaatgata tctggtatat tttgttttct
     4921 cgaatgtaat acaattgtcc cgaaccgtgt tgtatgaaaa gttttagctt ctgtatagaa
     4981 accataactt ttcttgacaa tcacagtcac aggagctatt ccactattgg taggtggaga
     5041 agtgaaaata tcatagttgg ccatagaaag tccaacttga tgaaacaata gtttgattct
     5101 ctggttttct tgctcacctc tgatattggt agctagttca gggaatatag ccatatcggc
     5161 gtcaaaatgg ctaaaaattc gctcaatatg ttgtgcttct atttgattag cgacgttcca
     5221 agttactaat tttaaggttt tagtcttatt tgatgcagaa gaaagggttt tatctgttcc
     5281 gaataatagt aatatgagcg atagtaagag caaaatgcca gagtaaaacc gtatttgttt
     5341 atttttcttg taaaaagata gggaaaaaaa tacgaaactt aaaatagcag ccatagttgc
     5401 agtagctaag gggaaggcat aaatctgtgc caagataggt ctggtagata gccaaatatt
     5461 aagattagaa gatggaaaaa aagaataagt tatgataggg ataacaaaga gaatgaccga
     5521 aagggcagag agaaatgttt taatcattgt gtgagtacct caatttgcaa tggttgctcg
     5581 gagctaatgt gactttgtga ctttacttga ttgatattct ttttcttgtc ttcctcatag
     5641 attaagtaca acccaagtaa aaaaagtcca atttaagatt gaaatgatta aaaggcacag
     5701 aaatgcaaga caattatact acaaaaggca aacatttgac aatcgatagc cgtcgcttaa
     5761 tcgaaagatg gaaaaaagaa gggaaatcaa atagagaaat tgcctctctg cttggaaaag
     5821 ttcctcaaac tatccacact gaaatcaagc gtgggacagt ccgacaatgt cttggaaaag
     5881 ggcgcttcaa agaggtttat tctgccgact acgctcaaca gtcttaagaa actaaaggaa
     5941 aagattctcc actatacata accaaaaatt ttcgcctgaa atgatggtta tggttaaagg
     6001 ggttaacgtg ggaatttcaa ccatttacta ttggattcat cgtggaaaat tggggttaag
     6061 caagcaggat ctgctttatc ctagaaaagg aaaatcgctt aagaaatagg ctagcaccaa
     6121 ctttaaaccc actggtcaat ctatcgaatc ataattcgct cattttttta aaaatacata
     6181 gacgtaaaaa aaagagggtt aagtgatgaa gaatagtgct attgggagta attggaagga
     6241 tgtccatctg agctctttag caaggaggaa atccttgaaa gtgatatgcg agtggctatc
     6301 atgagcgagt tgattgaggc taggtatgaa caaggaatca gtcagaaaaa gctggaagaa
     6361 gtcagtggaa taagccagcc tgtcatagct aggatggaga caggaaagac tagtcctcag
     6421 ttggatacag tcttaaaagt cctagccagt ttaggaaaga cactagcagt cgtcccactt
     6481 gaacagggaa aaagttgact agaatcagtt atagtctttt ctaataacag gtcatagtca
     6541 cttataagaa ttactaataa catgttttag tattctaatt ggaatatagc tgtaaagtaa
     6601 gaattacaaa ggatttgaga cgtttgcttc aagtcttttt cttttgtccg aaacagatat
     6661 atagtttcaa actatatcaa accctaattt tttacaatta tacagacgct ttcttttctg
     6721 ttaagatagt ttcaacaaca aattttggag gacacatcat gtcaactaca atcatcggtt
     6781 tccctcgttt gggcgaattc cgtgaattaa aatttacaac tgaaaaatac tttagaaaag
     6841 aaatctcaga agaagaactt ttagcagcag caaaagactt gcgtgctaaa cactggaaca
     6901 ttgtcaaaga aaaaggcatc actgaaattc catcaaatga cttttctcac tatgataact
     6961 tcctagatgc ggctttcctt ttcaacgtgg tgcctgcatc cgttcaaaac ttggacttgt
     7021 ctgaccttga gcgctacttc gctttgggac gtggttacca gggagaaaaa ggggacgttc
     7081 gcgcccttcc aatgaagaaa tggttcaaca ctaactacca ctacatcgtt cctaaatttg
     7141 aaaaagacac tcaagtaaaa ttggctggtc acaagatttt cgatgagttc caagaagcca
     7201 aagaacttgg attgaacact cgtcctgttc ttgtaggtcc cttcactttc cttcaattgt
     7261 cagactttga agaaggcgtg aaagcagacg acttcgtaga tagcttagtg tctgcttacc
     7321 aagaagtttt tgctaaattg gctgaacttg gtgcgactcg catccaattg gatgaagcgg
     7381 ctcttgtaaa agacttgaca gctgaagaaa aagctctttt cttgaacctt tacaacaaac
     7441 tcttggctga caaaaaaggt cttgaagtct tgcttcaaac ttatttcggt gatgttcgtg
     7501 acgtatacgc tgaccttgta aacttaccag tagatgctat cggtcttgac tttgttgaag
     7561 gtaagaaaac tcttgaactc gttaaaggtg gcttcccagc tgacaagact ctctatgtag
     7621 gtattgtcaa tggtaaaaac atctggcgca acaactacga aaagagcttg actgttcttg
     7681 agcaaatccc agctgaaaac atcgttttga caagctcttg ctcacttctt catgtgccat
     7741 ttacaactgc taatgaagaa tttgaaccag cactcttgaa ccactttgcc tttgcagttg
     7801 aaaaattgga tgaaatccgt gacttggatg ctatccgaaa tggtcaaggt tcagaagctc
     7861 ttgcagccaa caaagaactc tttgcgactg agcgtgttgg tgaaaatgct gaacttcgtg
     7921 cgcgtatcgc tggcttgaca gacgcagact acactcgttt gccagccttt gcagaacgtg
     7981 aagctatcca agaagaagct ttcaaacttc cagctcttcc aacaacaacg attggttcat
     8041 tccctcaaac aaaagaagtt cgtgccaaac gtttggctta ccgtaaaggt gaattgtctc
     8101 aaaaagagta cgacgctttc cttgctgaaa cgattgacga atggatcaag tggcaagaag
     8161 atattgactt tgatgtcctt gttcacggtg aatttgagcg taatgacatg gttgagtact
     8221 tcggtcaaaa cttgtcagga tacctcttct ctaaaaatgg atgggtacaa tcatacggta
     8281 tgcgtggggt aaaaccacca atcatctggg gtgatgtcac tcgtcttaac cctatcactg
     8341 ttaaatggtc tagctatgca caaagtcgta caaacaaacc tgttaaaggt atgttgactg
     8401 gacctgttac catccttaac tggtcattcc cacgtgaaga catctctatc aaggattcaa
     8461 ctctccaaat cgcccttgct atcaaggatg aagtacttga ccttgaagct gctggtgtga
     8521 aaatcatcca aatcgacgag gctgctcttc gtgaaaaatt gccactccgc cgtagcgact
     8581 ggtacgaaga ctaccttgac tgggctattc ctgccttccg cttggtacac tcaacagtag
     8641 cgccagacac acaaatccac actcacatgt gttactcaga atttacagat atcatcccag
     8701 ctatcgataa catggatgca gacgttattt cctttgaagc tagccgttca aaccttgaaa
     8761 tcttggacga actcaaagcg aaaaacttcc aaacagaagt gggacctggg gtttacgata
     8821 tccactcacc tcgtgtacca aatgaaggcg aaatcgacaa cacaatcgaa gtcatccttg
     8881 ctaaagtgcc aagcaagaaa gtttggatca accctgactg tggtttgaaa acacgtggta
     8941 tcccagaaac aaaagaaagc ttgatccgcc ttgttgaagc agctaaagct gcgcgtgaga
     9001 aattgtaaga ttggatttct ctccatacag tggttgttca aaaagaaatc aactagaaaa
     9061 ggttattaca tatgtcacgc caaacaccgt cactctcatt tgaagtgttc cctccaaacc
     9121 cagccgtggg taatgataac attatttcag ccttgcagga tatgcaggag ttggctcccc
     9181 attttatcag tgtaactgcc agcaataata aatttaatat caaggaaacg acggttcgtt
     9241 tggctgactt tatccaaaat gatttggcga ttccgaccat tgcccacttg ccagctattt
     9301 atctaactaa ggacaaggtt gctgaaacta ttgctgactt ggacaaagtt ggggtgcaga
     9361 aaatcttggc tcttcgtggg gatattattc cagacgtgga accacaaaag gatttccgct
     9421 atgcaacaga cttgattgag tttatcaagg aacaaacccc tcactttgat attattggag
     9481 cttgctatcc agaagggcat ccagattcgc caaatcagat ttcagatatt caaaatctta
     9541 agaagaaagt ggatgcaggc tgttcgagcc tcgtaactca gctcttcttt gacaatgagc
     9601 gcttctatga ttttcaggac aagtgcatct tggctgggat tgatgttccc attcatgcag
     9661 gaattatgcc aattctgaat cgaaatcagg ctctccgact cttgaagact tgtgagaata
     9721 tccatcttcc acgcaaattt aaagccatct tagacaagta tgagcatgac cctgagtcgc
     9781 tcagagcagc aggacttgcc tatgcagtgg accaaatcgt ggacttggta actcaggatg
     9841 ttgccggtgt gcatctctat acgatgaata atgctgatac agcaaaatac atccatcaag
     9901 caacccatgc cttgtttaat caccagtctc taggataata aaagcaaacc attcttctca
     9961 ggtgagggga atggttcctt tttaatggta aagacctcac tttttaagaa aaatatgata
    10021 aaataaattc tgtacgtact tgatacaaag atgaaggtat taaataatac aatgcattta
    10081 aactgtaaga tttaacgaca cgagtgagtc aaatcgatgt tatttgacga gagagttagt
    10141 aaagcattta actaatcgcc cgatagcgat tagcgtgaaa gctttagata ctttagtatt
    10201 aaacctttct aatgatttat atcttgaaaa ctgaactcgc ctacaactct gtggaaaaag
    10261 ataaatctcc ctaggagcag tcgctccgtc gttcgatttc ctattttcct ttgagttgct
    10321 tgacggctta gtatcttgag taattgaatt ttggtctcat ttcttaggaa aaaagataag
    10381 cttcctagca ctcgtcgagt gcgacgtcac cttcctattt ttctacagaa atgttcggca
    10441 agccgaaccg tccaaaatat cttgtgtaat tgaacacggc cgaaaagctg tgtaaaaaag
    10501 ataaactgtc ttgtcttcat cgaagacttc gtcagtttcc tatttttact ttgcttttga
    10561 cgtccttggt atcttgatct ttgtaggcaa ggcgtataat ttcatcaatc caaaggggat
    10621 taaaatggca aaacaagtgt ttcaaacgac ttttgcgggt cgtgagttaa ttgtagaaac
    10681 tggtcaggtt gctaagcaag caaatggctc tgttgtcgta cgttacggtg agtcaactgt
    10741 cttgactgct gccgttatgt ctaagaaaat ggcaactggg gatttcttcc cactccaagt
    10801 caactacgaa gaaaaaatgt atgcggctgg gaagtttcct ggtggcttta tgaaacgtga
    10861 aggacgtcct tcaacagatg cgaccttgac agcgcgtttg attgaccgtc cgattcgtcc
    10921 tatgtttgcg gaaggtttcc gtaatgaagt ccaagtcatc aatacagtgc tttcttatga
    10981 tgaaaatgca tctgcaccaa tggctgctat gtttggttca tctttggcac tgtctatttc
    11041 agatattcca tttgacggac caattgctgg ggtacaagtg ggatatgtag atggccaaat
    11101 catcatcaac ccaagtcaag aacaagcaga gcaatctctt cttgaattga cagtagctgg
    11161 aaccaagcac gctatcaaca tggtagagtc tggtgccaaa gaattgtcag aagaaatcat
    11221 gttggaagcg cttcttaaag ggcacgaagc tgtcaaagaa ttgattgcct tccaagaaga
    11281 aatcgttgct gctgtcggta aagaaaaagc agaagtggaa ttgcttcacg tggatgctga
    11341 attgcaagct gaaatcattg cagcctacaa cagtgacctc caaaaggcag ttcaagtaga
    11401 agagaaattg gcccgtgaag ctgcaactca agcagtgaaa gaccaagtga ctgccgttta
    11461 cgaagaaaaa tatgcgaacc acgaagaatt tgaccgtatt atgcgtgatg tggctgaaat
    11521 cttggaacaa atggaacacg cagaagtgcg acgtttaatt acagaagaca aggtgcgtcc
    11581 tgatggtcgt aaggtcgatg aaatccgtcc tttggatgcg gttgttgact tccttcctcg
    11641 tgtacatggt tcaggtctct ttactcgtgg gcaaactcaa gctctttcag tcttgacctt
    11701 ggctccgatg ggagaaactc aaatcattga tggtttggat ccagagtaca agaaacgctt
    11761 tatgcaccac tataacttcc ctcaatattc tgtaggggaa acaggtcgtt acggtgcgcc
    11821 aggtcgtcgt gaaatcggtc acggtgccct tggtgagcgt gctcttgctc aagtcttgcc
    11881 aagcttggaa gaattcccat acgctatccg tctagtagca gaagttttgg aatcaaacgg
    11941 ttcttcatct caagcttcta tctgtgcggg aactcttgcc cttatgactg gtggtgtgcc
    12001 aatcaaggcg ccagtagctg gtattgctat gggacttatc tcagatggaa ataactacac
    12061 agtattgaca gatatccaag gtttggaaga tcactttgga gatatggact tcaaggttgc
    12121 aggtactcgt gatgggatta cagcccttca aatggatatc aagattcaag ggattactgc
    12181 agaaatcttg acggaggctc ttgctcaagc caagaaagcg cgttttgaaa tccttgatgt
    12241 cattgaagca accattccag aagttcgtcc agaattggct ccaactgctc cgaaaattga
    12301 tacgatcaag attgatgtgg acaagattaa gattgtcatc ggtaagggtg gagaaaccat
    12361 cgacaagatt atcgctgaaa caggtgttaa gattgatata gacgaagaag gaaatgtgtc
    12421 tatctactct agtgaccaag atgctattaa ccgtgccaaa gaaattattg ctggtttggt
    12481 tcgtgaagcc aaagtggatg aagtttaccg tgctaaagtc gttcgtatcg agaaatttgg
    12541 tgcctttgtt aacctctttg ataagacaga tgcccttgtt catatctctg agatggcttg
    12601 gactcgtacc aatcgtgtag aggatttggt agaaatcggg gatgaagttg atgttaaggt
    12661 tatcaagatt gatgaaaaag gccgtatcga tgcctctatg aaggctcttc tacctcgtcc
    12721 gccaaaacct gagcatgatg aaaaaggtga aaagtctgag cgccctcacc gcccacgtca
    12781 tcacaaggat cacaaaccta agaaagaatt tacagaaaca ccaaaagatt cagagtaaga
    12841 aaaggagaaa tgtatggggt ggtggcacga aaccattgat atcgtaaaag aaaatgatcc
    12901 agcggcccgc accactttgg aggttttgct gacttatcca ggtgtcaagg ccttggcggc
    12961 ccaccgtctc tcgcattttc tctggaagta cgacttcaaa ctcttagctc gtatgcacag
    13021 tcagttttgg cgcttttgga ctcagattga gattcatcca ggagcccaga ttgattcagg
    13081 tgtctttatt gaccatggtt ctggtctggt gattggagag acagcgattg ttgaaaaagg
    13141 cgttcttctc tatcacggag tgactctcgg gggaacaggg aaagactgtg gcaaacgcca
    13201 tccgactgta cgaaagggag ccctcatatc agcccatgcc caagttatcg ggcctgtgga
    13261 aattggtgaa aatgccaagg tcggtgctgc agcagttgtc gtagcagatg tacctagtga
    13321 tgtgacggtt gtcggtattc cggccaagat tgtccgtctt catggtaaga aagatgagcc
    13381 tgttattcac gaagtcgaag aaaaacggga gtattatgtc aataaactcg agcaggctaa
    13441 agatgccagt cacagatcgt ctggtttgta gaggatacct atatgattca agcaagaaac
    13501 aagttaagcc aagaggagct atctgaggcg aaaaaagtaa ttaactgttg ccaaaactat
    13561 gacggtacct atcgcgatcc ctatctctct aacatgctta attttgaccc aaacatgccc
    13621 gcctttttcc tttattatga aaaaggcaaa cttgttggtt tattaactgt ctatgcagat
    13681 gaccaagatg tagaagtgac gatactggtt catccaggtc atcgccgtca ggggattgcg
    13741 cgtgcattgt ttactagttt tgagagagaa acagcttctt tccccattcg gtcagtcact
    13801 tttcagacag aacgtatttt tttagagaat catcctgact ttgccagtaa ctggggacta
    13861 atcgaggatg aagagacaga aacctggtta ggtaaggata gaagaccata tcagttagca
    13921 aaactttcta atcttgaagt tttgttagca gatagttcgt atcaggagca aattagccag
    13981 ttaaaatttc aggcattttc aggggaacat gaatcgagag aagttgtgga tagatatgtc
    14041 gctgaagctc tgaaggatcc agaaagtcgc ttatatattt tgttaaaaga cggtcaggtt
    14101 attgggactt gcacggttga tttatcgagc gatacgaatt acttctacgg tttagcaata
    14161 tcagaacctg aacgtggaaa aggctatgga agctacttag caaaatccct tgtcaaccaa
    14221 ctaattgagc aaaatgataa ggaatttcag attgcagtgg aagatagcaa tgtaggtgcc
    14281 aaacgtttgt atgaaaaaat tggctttgtc aaacagacac aggtggttta tctgaatgag
    14341 aaaggagcaa gggattccga agtgtagaga cattcggact gaaatttact tgagctctta
    14401 gtttagtgat gaaactaaca gttcttggat tttagctttc ttgattatga tttatgatta
    14461 aaatctatga caccatgtct cgtgatttgc gagaatttgt cccgattgag gacggcaaga
    14521 tcaagatgta tgtttgtggg ccaaccgtgt acaactatat tcacgtggga aacgcccgtt
    14581 cgacggtagc ttttgatacg attcgtcgct attttgagta ccgtgggtat aaggttgcct
    14641 atatttccaa ttttacagat gtggatgata agattatcaa ccgtgccagg gaagaaggca
    14701 tcacacctca ggaggttgcg gataagtaca tcgctgcctt tcgtgaggat gtgacggcct
    14761 taggcgtgaa acctgcgact cgccatccgc gtgtagtgga gtttatggca gacatcatcc
    14821 gttttgtgga agacttgatc gagaaaggct ttgcctatga gagtcaaggg gatgtctatt
    14881 tccgtgtaga aaaatcccac aactatgcta aattggctaa taaaaccttg gaagatttgg
    14941 agctaggtgc ttcaggtcgt accgatgaag aaacggctcg taaggaaaat cctgtagatt
    15001 ttgctctatg gaaatcttcc aaaccaggtg agatttcttg ggatagtcct tggggacctg
    15061 gacgtccggg ttggcatatt gagtgttcag tcatgtcgac agagatttta ggtgatacca
    15121 ttgatatcca cggtggtgga gctgacctag agtttccaca ccacaccaat gaaattgccc
    15181 aatctgaagc taaaacaggc aaggcttttg ctaactactg gatgcacaat ggctttgtca
    15241 atatcgacaa tgtcaaaatg tctaagtcct tgggtaactt cattacggta cacgatgccc
    15301 ttaaaactct tgatgggcaa gtacttcgtt tcttctttgc gacccagcac taccgtaagc
    15361 ctatcaactt cacggaaaag gcagttcgcg atgccgagac caatctcaag tatctgaaga
    15421 atacttacga acaaccattt acaggaaacg tggatgccca agagttacaa aactttaaag
    15481 ataagtttgt agcagctatg gatgaagatt ttaatgctgc caacggtatc acagttgtct
    15541 ttgaaatggc caaatggatc aactcaggga actatgatgc aagtgtcaag caagctcttg
    15601 cagatatgtt agaaattttt ggaattgtct ttgttgagga agttttggat gcagagattg
    15661 aagacttgat tcaaaaacgc caagaggcgc gtgccaatcg agactttgag acagcagacc
    15721 aaatccgtga ccaattggtt actcaaggaa ttaagctcct tgataccaag gatggagtga
    15781 ggtggacacg tgattgatgt caatctcatt aacgggattg cgctagcctt tgagggggat
    15841 gcggtgtatt ctatgtatat tcgccgtcac ctcatcctca aaggtatgac caaacccaat
    15901 aaactccatc aagaagcaac caagtatgtg tcagccaagg ctcaggctcg cctgattgct
    15961 ctcatgttgg aggagcaggt cctaacggaa aaagaagaag aaatctacaa acgtggccgc
    16021 aataccaata gccacacaaa ggctaaaaat gcagatgtcg tgacttatcg tatgtccacg
    16081 ggatttgaag cggttatggg ctatctccat atgactgaga atctggaacg tcttgagagt
    16141 ttggtttcat ggtgcatcca aaaagtggag ggctagaaca tgagggaaaa agaactacaa
    16201 gactggtttc ctgaggctcg gatttcagac caaccagtag agaaagaggg ctatctcacg
    16261 ctccctttag cttctcagca gtggattttg ctggaggaag ctgggctcag cgagcgtgaa
    16321 aagcagttgg ttgccctttt gacccagcag gagcaggctc gttcgctaaa cccttggtat
    16381 tcctatctgg ttgaaggcaa gggacaggca ccgcaagttt ttaaaaagat tcagttggtt
    16441 tattgccatc tttcttattt tcagcaggaa aatctggctt cttggctaga tatgatgcgg
    16501 actctttttc cgaattgtca gacagtgcta caggtcggat ctcaggatta tgttttcgtg
    16561 cttcaacaag acaaatacac ttctgtaaga gatattttaa gtgatacgat tgaagcggtt
    16621 gagtatgact ttggacttcg tctttctatc atgttgggtc aggtttggtc tcagacagga
    16681 catcaagccc tatcagactt aatcaaagct gagcgggatt tgttcaagac atggtggcgt
    16741 cagggtcacc aaggtgttca tactttttct cagctctatc tttggagtat gggagaaaga
    16801 ctcgtggact tgaagccaat taaagaatgt ctacaccaga tgattttgga tcaagatcag
    16861 attcaggaaa tcattctctc tctttgggaa aatagtgctg ttctcactaa aacagcccag
    16921 caactctatc tgcaccgcaa ttctctccaa tacaagattg ataaatggga agagttgaca
    16981 gggcttcagt tgaaagagtt gaccgacctg accttgtgtt atcaattgat tttaggttct
    17041 ttgtcaacta tagttggttt gtaaagaagt taatatttgg agaagaggat ggccatcttc
    17101 tccattttta tgtgcagagt tatagtggat tgatgctggg aaagtacact gtgactgcta
    17161 aaacattcct agaagttgct ttgatttccc taatctattt atgcaaattt tatgttattt
    17221 tactataaca gttgttgcta agccaaataa tagtggggaa gttcatttag acgtaagcat
    17281 tgaagataat cagggaggta gtgggcataa tttcagttct gtttcaagta gctcacaaac
    17341 agctaaatat gaagaaactg gttataataa caatttatca ttatatataa cgattgataa
    17401 aacgtctgat gcaacagctc ttttgaaatt aaagttgaat aatgttgata atcaacctgc
    17461 tactgaagtt cctagttcag gaattactgt aaaattaaat actaaagata atgctggaaa
    17521 ctggacaagt gcttcgaata aaaaagaaat aacagtaaaa attgtttctg ctaaaccgac
    17581 atatccagac aaaatcttag tgaaaaatcc tgataatata aaagatacag aaaaaaatgc
    17641 cattattgaa aaattgaaag aggcaaataa aaatcatcca gcaggagctc caacctttgc
    17701 taaaggtgaa ggagagcatg caaatgatat tgtagcaact tattcagatg gtacaactta
    17761 ttatgtaccg ttaaatgatg tgacaaaata tgcgaggtag tggctgtacc actcacttat
    17821 tcacctcctc gtgatttgta gtagtgatag gctttctcac tattattata aaacaaaata
    17881 aagatcacaa cactttttca ttctgtgttg tgccttgagt gaaacgaaag gaatgaatta
    17941 taaatatgaa aagtatagtc actagcatag atgagcgctt gcgtactcgc ctacgagtga
    18001 ttatctggaa gcaatggaag aagaaatcga gacgattatg gggattgctt aagttagggg
    18061 ttcctaaatg gatagcagat aaggtatctg gctggggcga ccactatcaa ttatattaaa
    18121 atgaaataag aataggacga atcgatcagg gaagtcaaat cgatttctaa caatgtttta
    18181 gaagaagaga tgtactattc tagtttcaat ctactatagt agctcagaag tcggtactta
    18241 aacgtgctat atcaaaacca gtccttgaaa aacgtgaaca ggtttcgtgt ttggattatt
    18301 accttgaacg acatgcgtta aaagttagtt gaaccgccgt atgccgaacg gcacgtacgg
    18361 tggtgtgaga ggggcgagag attatcccct actcgatatt ttttttcgta tttcataaac
    18421 atttcatatt tgggttttat aatagtctta caaatatgga ggtgacaaat gaatccaatc
    18481 caaagatctt gggcttatgt cagcagaaag cgactgagaa gttttatttt atttctgatt
    18541 ttattggtct tattggccgg aatttcagcc tgtttgactc tgatgaagtc caacaaaaca
    18601 gtagaaagca atctttataa atcactcaat acatcttttt ctattaagaa gatagagaat
    18661 ggtcagacat tcaagttgtc agacctagca tctgtaagca agattaaggg gctggaaaat
    18721 gtctctcctg aacttgagac ggtcgcaaaa ctaaaagaca aggaagcagt gactggcgag
    18781 cagagcgtgg agcgtgatga tttatcagct gcagacaata acttggttag cttaacggct
    18841 cttgaggatt catccaagga tgtaaccttt accagttcgg ctttcaatct aaaagaaggg
    18901 cgacaccttc aaaaagggga ttccaagaaa atccttatcc acgaagaatt ggctaagaag
    18961 aacggtcttt cacttcatga caagattggc ttggatgctg gtcagtctga atctggaaaa
    19021 ggacaaacag tagagtttga gattattggc atcttttctg gtaaaaaaca agagaaattc
    19081 acaggcttgt cttctgactt cagtgaaaat caagtcttta cagactatga aagtagccaa
    19141 acccttttgg gcaatagtga agctcaagtc agtgcagcac gcttctatgt agaaaatcct
    19201 aaggaaatgg acggactcat gaagcaggta gaaaacttgg ccttggaaaa tcaaggctac
    19261 caagtcgaaa aggaaaacaa ggcttttgaa caaatcaaag actcagttgc aactttccaa
    19321 accttcctga ccatcttcct ttatgggatg ttgatagcag gagctggagc cttaattctg
    19381 gttttgtctc tctggttgag agaacgggtc tatgaagtgg ggattttact tgcacttgga
    19441 aaaggcaaga gctcgatctt cctacaattc tgtttagagg tagttttggt atctcttgga
    19501 gctttgcttc cagcatttgt tgcaggaaac ggaatcacaa cttacctact ccaaactcta
    19561 ctagcaagtg gagatcaggc aagcttacaa gatacactag ccaaagcaag cagtttatca
    19621 actagtatct tatcttttgc agaatcctat gtttttctag ttctgcttag ttgcttatct
    19681 gtagcccttt gtttcctatt cttatttaga aaatcaccga aagaaatttt atcatctatt
    19741 agttaagaag gagaaatcat gactttatta caattacaag atgttaccta ccgttataag
    19801 aatactgctg aagcagtcct atatcagatc aattataatt ttgaacccgg aaaattttac
    19861 agtattattg gggagtcagg agcaggaaaa tccacactct tgtccctact tgctggtcta
    19921 gatagtcctg ttgaaggttc tatccttttt caaggagagg atattcgtaa gaagggctat
    19981 tcttaccatc gcatgcacca tatttccctg gtctttcaaa attataactt gatagattat
    20041 ctttctccgc tggaaaatat ccgattggtc aacaaaaagg caagcaagaa tacacttctt
    20101 gagcttggtt tggatgaaag ccagatcaag cggaatgttc tccagttatc aggtggtcaa
    20161 cagcaacgtg ttgccattgc tcgcagtttg gtctcagaag ctccagttat tctagctgat
    20221 gagccaacag gaaatctgga tcctaaaact gctggagata ttgtcgaact actcaaatca
    20281 cttgcccaga aaacaggtaa atgtgtgatt gtcgtaactc acagtaaaga agtggcacaa
    20341 gcgtcagata ttacacttga attaaaggat aagaaactga ctgaaacgcg caatactagt
    20401 aaataatttg agcttatttt gatagaatga ttaaaacaaa atctagaaag ggaatctatg
    20461 ttacacaacg catttgccta tgttacaagg aagtttttca aatcgattgt catcttcctg
    20521 attattctcc tcatggcgag cttgagtttg gtcggcttgt caatcaaggg agctactgcc
    20581 aaggcttctc aggagacctt taaaaatatc accaatagct tctccatgca aatcaatcgt
    20641 cgcgtcaacc aaggaacgcc tcgcggtgct gggaatatca agggtgaaga catcaaaaaa
    20701 atcaccgaaa acaaggccat tgagtcttat gtcaaacgta tcaacgctat cggagatttg
    20761 actggatatg acctgattga aacgccagaa accaagaaga atctcactgc tgatcgtgcc
    20821 aaacgttttg gaagtagctt gatgattaca ggtgtcaatg actcctctaa agaagacaag
    20881 tttgtctctg gttcttataa actagtcgaa ggagagcact taaccaacga cgacaaggat
    20941 aaaatcctct tgcacaagga cttggcagcc aaacacggct ggaaagtagg ggacaaggtt
    21001 aaactggact ctaatatcta cgatgcagat aatgaaaaag gagccaagga aacagttgaa
    21061 gtgacaatca agggactctt tgatggtcat aataagtcag cagtaaccta ctcacaagaa
    21121 ctttacgaaa acacagctat tacagacatt cacactgctg caaaacttta tggatacaca
    21181 gaagacacag ccatttatgg ggacgcaacc ttctttgtaa cagcagacaa gaacttggat
    21241 gatgttatga aagagttgaa tggcatcagt ggtatcaact ggaagagcta cacactcgtc
    21301 aagagctcct ctaactaccc agctcttgag caatctatat ctggtatgta caagatggcc
    21361 aacctcctct tctggggtag cttgagcttc tcagttctcc tccttgccct cttgctcagc
    21421 ctttggatca acgcccgtcg caaggaagtg ggaattctcc tctctatcgg cctcaagcag
    21481 gcaagtatct tgggtcaatt catcaccgaa tctatcttga ttgctatccc tgctctagtt
    21541 tctgcttact tcctagctaa ttacactgcc cgtgcaattg gaaacactgt ccttgccaat
    21601 gtgacttcag gtgttgccaa acaggctagt aaggcggctc aagcctctaa ccttggtggt
    21661 ggtgcagaag tagatggctt tagcaagacc ttgtcgagcc tagacatttc tattcagaca
    21721 tcagacttta tcatcatttt tgtccttgcc ttggttctag tggttctcgt tatggcgctt
    21781 gcttcaagca atctccttag aaaacaacca aaagagctct tgctggatgg tgaataaatt
    21841 tgaaaaaatg agtctggaat aaagattgca tcttgtgttt ctattcaaga atagtggata
    21901 ggaatggcta tttaacaatt caaaataaat ccgaaagcag tggtgaaaat cattgctttc
    21961 agttgttttc tttgtacttt attgcttaaa tataatatac taaagctatg gaatttatga
    22021 gaaaggaatt tcacaacgtt ttatctagtg atcagttact tacagacaaa aggccagcaa
    22081 gagactataa tagaaaatag agtaggtatt tattctaaga aaaataaaaa atagagagca
    22141 gttaaagtat gaaaatttta attgtagaag atgaagagat gatccgtgag ggggtcagtg
    22201 attatttgac ggattgtggc tatgaaacta ttgaggcagc ggacggtcag gaagctctgg
    22261 agcaattttc tagctatgag gtggccctgg ttttactgga tatccagatg cccaagctta
    22321 acggcttaga agttctagct gagattcgta aaaccagtca ggttcctgtc ttgatgttga
    22381 cagcttttca ggatgaggaa tacaagatga gtgcctttgc ctctttggca gatggctatc
    22441 tggaaaaacc tttctccctc tccctcttaa aagtgagggt ggacgcgatt ttcaagcgct
    22501 actacgatac aggacgaatc ttttcttaca aggataccaa ggtggacttt gaaagctaca
    22561 gtgcaagcct cgcaggtcaa gaagtgccta tcaatgccaa agagttggaa attctggact
    22621 atctagtgaa aaatgaaggc cgggccttga ctcggtctca gattatcgat gccgtctgga
    22681 aagcgacaga tgaggttccc tttgaccgtg ttattgatgt ttatatcaag gaattgcgga
    22741 aaaagctaga cttggattgt atcctcactg tgcgcaatgt tggttataaa ttggagcgaa
    22801 aatgaaacga acaggtttat ttgcaaagat atttatctat accttctcga tatttagtgt
    22861 tctggttatc tgccttcatt tagctattta ttttcttttt ccttcgactt atctgagtca
    22921 tcgtcaggaa accattggtc aaaaggcaac agccattgcc cagtccctag aagggaaaga
    22981 taggcagagt atcgagcaag tgttagattt gtattcccag actagtgata tcaaggggac
    23041 cgtcaaaggt gagatgaccg aggacaagtt agaagtcaag gacagtcttc ctctggacac
    23101 agaccgccag acaacctctc tctttattga ggagcgcgag gtgaaaacgc aagacggtgg
    23161 tactatgatt ctccagtttc tagcttccat ggatttacaa aaggaagcgg agcaaatcag
    23221 tctccagttt cttccctata ccttgctggc ctcctttctg atttccctct tggtggccta
    23281 catctacgct cggactattg ttgcaccgat tttggaaatc aagcgggtga cccgtcggat
    23341 gatggacctg gattcccaag tgcgattgcg cgtggattct aaggatgaga taggtaatct
    23401 caaggaacaa atcaatagcc tctaccagca tctcttgact gttattgcgg acttgcatga
    23461 aaagaatgaa gccattctcc agctggagaa gatgaaggtc gaattcctac gaggagcttc
    23521 tcatgaattg aaaacaccgc tggctagttt gaaaatccta atcgaaaata tgagagagaa
    23581 tatcggtcgt tataaggata gagaccagta tctgggagtt gccttgggga ttgtggatga
    23641 actcaatcac catgttctgc agatactttc cctctcttct gtgcaggaat tgcgagatga
    23701 tagggaaaca attgacctcc tccagatgac gcaaaatctg gtcaaagatt atgccttgct
    23761 agccaaggaa agagagctcc agatagacaa tagtttgacc catcagcagg cttatctaaa
    23821 cccatcagtt atgaagttga ttctttctaa tctcatcagc aatgccatta agcactctgt
    23881 tccaggtggc ttagttcgaa ttggagaaag agaaggagaa ctttttatcg aaaatagctg
    23941 tagctcagag gaacaagaaa aactagccca gtctttttct gacaatgcta gtcgcaaggt
    24001 caaggggtct ggtatggggc tctttgtggt taagagtcta ttagaacatg aaaaattagc
    24061 ttatcgtttc gagatggagg agaatcgttt aaccttcttt atagattttc caaaagtcgc
    24121 ccaagactag ggagagaaag ggtttacata gatggagtta gaagaaaatc aatcgaaact
    24181 gcgggaaaaa ctagattttt ttggcaaaaa gtgataaaat gaacaatgta aatgggatga
    24241 cccataaaaa tatacaggag gcctgataaa atggcaatcg tttcagcaga aaaatttgtc
    24301 caagcagccc gtgacaacgg ttatgcagtt ggtggattta acacaaacaa ccttgagtgg
    24361 actcaagcta tcttgcgcgc agcagaagct aaaaaagctc cagttttgat ccaaacttca
    24421 atgggtgctg ctaaatacat gggtggttac aaagttgctc gcaacttgat cgctaacctt
    24481 gttgaatcaa tgggtatcac tgtaccagta gctatccacc ttgaccacgg tcactacgaa
    24541 gatgcacttg agtgtatcga agttggttat acttcaatca tgtttgacgg ttcacacctt
    24601 ccagttgaag aaaatcttaa attggctaaa gaagttgttg aaaaagcaca cgctaaaggt
    24661 atctcagtag aagctgaagt tggtactatc ggtggtgaag aagacggaat catcggtaaa
    24721 ggtgaattgg ctccaatcga agacgctaaa gcaatggttg aaactggtat cgacttcttg
    24781 gcagctggta tcggtaacat ccacggtcct tacccagtaa actgggaagg tcttgacctt
    24841 gaccacttgc aaaaattgac agaagctctt ccaggattcc caatcgtatt gcacggtgga
    24901 tcaggtattc ctgatgagca aatccaagca gctatcaaac ttggtgttgc caaagttaac
    24961 gttaacacag aatgccaaat cgcattcgct aacgcaactc gtaaatttgc tcgtgactac
    25021 gaagcaaacg aagcagaata cgacaagaaa aaactcttcg acccacgtaa attcttggct
    25081 gacggtgtaa aagctatcca agcatcggtt gaagaacgta tcgacgtatt cggttcagaa
    25141 ggtaaagcat aatctagctg aataatacag ataaaacctg cctgtgaggg tgggtttttt
    25201 gatttcaagc tactcgtttt agtatagtaa actgaatcta gactagcaca atgctgcttc
    25261 tatagcgttt tgaaactaga ataggataac ataactgcta aaagatttct ataaattcat
    25321 ttgattttcc taatcaattt gttcgtatcc tatttcactc cactataaaa tattcttatc
    25381 aattgatttg aatgccaaaa ttccatcgtt ccggtcttat ttcatttggc tataaaaaac
    25441 tctcctggga aattccagga gagtatgatt acttatttga acttgaatcc ttcgtaaata
    25501 agctccgttt ttggattttg tttcttaatc tgtttggcaa gtgccttcat catagaaata
    25561 ggaccacaca tatagacggt tgcatgttcg ggcacttctt tttgttcaaa attaagatag
    25621 ccgtcttttg tactgtcgat tagatggagt tcaaaattag gatttttctg agcatagtca
    25681 cggagtaaat caaggtagac tgcattttct tctccacgga agctatagta gaagtgaacc
    25741 cgtttatcta aaataggatg ttcacggatg taagagatga agggggtgat cccaatacct
    25801 ccagcaatcc aaacctgatt ttctcgtcct tcttctatga tcatgtgtcc gtaagctctg
    25861 tctagggtta ctttgctgcc ggcttgaaga ttatcataga tattcttggt atggtcgcct
    25921 gaatttttaa cagtaaagta aagagtttga ccatgacctc ctgagataga aaagggatgt
    25981 ggagcacttt caaagccttc ttggaaaatc tttagaaagg caaattgtcc tgattgatag
    26041 ttgaaaggtc tgctaagatg gatttgaatt tctctagtat cgtgatttaa gcgtttgaga
    26101 tgggtaattt tccctagata ggggaaggaa atcttttgat atagaaaaat gatataaaaa
    26161 ccagctagta agcctaaaag ggcatagcta ccaacaagaa aacttagaag attaaatgta
    26221 aggagacgat tgcccattat catgtagatg tgaaagagtc ctaaaatata ggctaggtaa
    26281 accaggcggt gaatccatcg ccaagcttcg tattggatgt atttgcctaa ataggcgaca
    26341 aggatgatgc cggcaaagat atagatggca agattaccaa actgagcagc taagcgagag
    26401 ccccacaaac cgcccatact aaagttatga aagattagta ggatgatgga gagaaaggct
    26461 gtgaatttgt ggacggtgta gaccttctcc aaaccgtgaa accagctttc tagtagtggg
    26521 agacgagtgg ctaggataaa agtcagagat aggcttgtta aagctagtcc tggaatcatg
    26581 aattggggag aagtgttcat ccaagtcaaa agagtcaaga taaaactagc tatgataaag
    26641 agtagtcctt tgactgattt catagaaaat tccatttcat ttagatttcg atttgttgta
    26701 aatgaatttg ttacatttta tcatagaaaa tgtatggtgt caaattgagg tctataaata
    26761 tctactatca tcaaaaaact ctccaatgaa ctagagagct aatttgttat tctgcagctt
    26821 gttgccaacg ttttgctagc atatgagaca ggttagaaat tgctaggtta aagctgaagt
    26881 agatgagggc aatcaggatg taaagactga atccctgaac gaataacctc agcgatataa
    26941 gcgccgtgat agagtcccac gcagagaaca gctgtccaat aaatcggaat catgatagta
    27001 tggtcactga taagaggtag gccataaaaa acaataacaa actgcaccaa gaggggagtg
    27061 ttttggtaaa attccacaaa gatgcgagct aaaatgcgta aaattggacg tttactggtt
    27121 gacatggcac caaagaagac tcctaagacc atggcgagga taaaggatcc aatcgctagg
    27181 gcaagagtaa agaggaaacc attgaaaaat tgtccaaaat cctgaaaata ggctgtccaa
    27241 gatgataaat ctgtcatagg gtatcctcct taatctgcgg tatgactaga tggtttgagc
    27301 ttgtaacggt cataaagttt ctgcaaacta ccatccttgc tccatttagt gaccaaggta
    27361 tcaagatagt cgttgagctc tgtatttgat ttcttggtaa caataccgta gtcagatggc
    27421 ttgaaactat catctagtag tgctgtccgt ttactagtgt agccagatag aatagagcgg
    27481 tcaacggaaa aggtatcgat acgatgagcg tgcagggaag taatcaattc tgggtaggaa
    27541 ccaagttcga cgaatttaaa cttcagacct ttctttttac ccagttcagt aatcaggcgt
    27601 tgggtgatag aaccttgggc gactccgatg gttttgccgt ttaggtcctc aatctttttg
    27661 attttggcag atttattgac caaaaatcca gaagcgtctg tgtagtaggg actggtaaag
    27721 ttgtagagtt ttttgcgttc gtccgtgatg gtaaaggtcg cgatatccat atcgacctgt
    27781 tcattgtcta gaagggggcc gcgggtttgt gctgtaaccg gcacatagcg aatcttgacc
    27841 ttgagttcat cagctaccat cttggccaag tcggtttcga taccagaata agtaccggtc
    27901 ttgggatctt tgtaaccaaa attgggaacg tcttgtttga caccgacaac cagttcgcct
    27961 cttttttgaa tgtctgcgat actagtatca gcctggactg gtttggcagc agcaaggccg
    28021 aaaaggctaa tcaataatgc tgataaaaag aatttttttt cataggcgcc tccttatttg
    28081 actttgtcac tttcgtggtt gataattttg ctgaggaatt gttgggcacg agcttcgctt
    28141 ggattgtcaa aaaagttatc gacatctgtc gtatctacta aaacttctcc gtcggccata
    28201 aagataatgc ggtccgcaac ctctcgagca aagcccattt cgtgggtaac gatgatcatg
    28261 ttcatcccat catgcgccag tttctgcata actgctagaa catctccgat agtctcagga
    28321 tcaagagcag atgttggttc atcaaagagg aggagttccg gatgcatagc aagaccacga
    28381 gcgatggcga tccgctgttt ttgtccacca gatagcatgg cgggatagga atctttcttg
    28441 tcccacatat ttacaaattc cagatatttt tgggcggttt tttcagcttc ttttttatca
    28501 attcctagaa ctttaatggg cgaaagtgtc acattttcta acaccgtttt gtgtggataa
    28561 aggttaaaat gttgaaaaac catgccgact tccttgcgaa gaggtaccaa atctttctgg
    28621 ctggcaccag caacttggtg cccattgact aggagacttc ctttgtcaac agcctctaaa
    28681 ccattgatcg tacggataag agtggacttc ccagagccag aaggtccaag caggacaaca
    28741 acttgtcctt tttcaaaacg gagattgatg ttgcggagtg cgtggtagtc tccgtaatat
    28801 ttttcgacgt ttttaaattc tactaaagcc atgagagatc tcctttatgt taggttttat
    28861 aacacgattc tacaataaaa gaatgttctt gtcaaaccat atctgaaaaa ttcactatag
    28921 tgaaataaga acaggaaaaa tcgatcggga cagtcaaatc gatttctaac aatattttag
    28981 aagtagaggt gtactattct agtttcaata tactataaaa tgttataaaa aagcaatctg
    29041 gatagagaaa acgtctaaat catgttataa tgaagcaata gaattcttag aaagagtgga
    29101 tgtctttttg ataacaccta cttatgaatg gcagtttgcc ctgcaggtag aagatgcgga
    29161 ttttacaaag atagccaaga aggctggact gggtcctgag gtggctcggt tattgtttga
    29221 gagagggatt caggaccaag aaagtctgaa gaagttttta gaaccttcct tggaggactt
    29281 acatgatgct tatctgctcc atgatatgga caaggcagtg gagcggattc gtcaggctat
    29341 tgaagaaggg gaaaatattc tcgtttatgg agactatgat gcggatggca tgacttcggc
    29401 ttctattgtg aaggaaagtt tggaacaact tggtgcggag tgccgagttt acctgccaaa
    29461 tcgttttacc gatggctatg gccctaatgc tagtgtttat aaatacttta tcgagcaaga
    29521 aggaatttcc ttgattgtga cggtggacaa tggggttgct ggtcatgagg ctattgcatt
    29581 ggctcagtct atgggagtag atgtcattgt gacagaccat cattccatgc ctgaaaccct
    29641 gccagatgct tatgctattg tccatcctga acatccagat gcggattatc cttttaaata
    29701 tttggctggt tgtggagttg ctttcaagtt ggcttgtgcc ctgttagaag aagtgcaagt
    29761 ggaattgctt gatttggtcg ctattggaac tattgcagat atggtgagtc tgacggatga
    29821 aaatcgtatc ttagttcaat atggtctgga aatgttgggt catacccagc gcattggtct
    29881 gcaagaaatg ctggacatgg ctgggattgc tgctaacgaa gtaacagaag aaacggttgg
    29941 tttccagatt gctcctcgtt tgaatgcctt gggccgcttg gatgatccca atcctgccat
    30001 tgatttgttg actggatttg atgatgagga agcgcatgag attgccctta tgattcacca
    30061 gaaaaacgaa gagcgcaagg aaatcgttca gtctatctat gaagaagcca agaccatggt
    30121 ggatcctgag aagaaggttc aggtcttggc caaggaaggc tggaatcctg gggttctagg
    30181 aatcgtggct ggtcgtttat tggaagaatt gggacagaca gtcattgttc ttaatataga
    30241 agacggtcgt gccaagggca gtgctcgtag tgtggaagcg gtcgatattt ttgaagctct
    30301 ggatccctat cgagacctct tcatcgcctt tggaggtcat gcaggtgcag cgggtatgac
    30361 gctggaagtt gagcaactct cagatttatc tcaggttttg gaagattatg ttcgtgaaaa
    30421 aggtgcagat gctggtggca agaataagtt aaacctagat gaagagttgg atttggaggc
    30481 acttagcttg gaaacggtca aaagttttga acgtttagct ccttttggaa tggataatca
    30541 gaaacctatt ttttatatca agaattttca ggtcgaaagt gctcgtacta tgggggcagg
    30601 taatgcccat ctaaagctga aaatttccaa gggtgaggcg agttttgaag tggtagcctt
    30661 tggtcaaggc agatgggcga cagagttttc tcaaaccaag aatctagagt tagcggttaa
    30721 attgtctgtc aaccaatgga atggccaaac tgccctccag ttgatgatgg tggatgcgcg
    30781 agtggaaggt gttcaacttt ttaacattcg tggaaaaaat gcagtcttgc cagaaggtgt
    30841 tccagtcttg gattttcctg gagaactgcc aaatcttgcg gctagtgaag ctgttgtcgt
    30901 aaaaaacatt ccagaggata ttactcagct gaagaccatt tttcaggaac agcatttctc
    30961 tgctgtctat ttcaaaaatg atattgacaa ggcttattat ctgacaggtt atgggactag
    31021 agatcagttt gccaaattgt acaagactat ttaccagttc ccagagtttg atattcgcta
    31081 caagctgaaa gatttggctg catatcttaa tattcaacaa atcttgctgg tcaagatgat
    31141 tcaagtattt gaagaactag gctttgtgac gataaaagat ggtgtgatga cagtcaataa
    31201 agaggcgcca aagcgggaga taggagaaag tcaaatttac caaaatctca aacaaaccgt
    31261 taaagaccaa gaaatgatgg cgctgggtac ggtgcaagaa atttatgatt ttttgatgga
    31321 aaaagagtag aagttaggaa agagttggga aatcaactct tttttgaaaa cagaccttca
    31381 ttttgaaaat catcaaaaaa atggtataat ggtaggaaaa gattcggctg aaagtatcag
    31441 aacttttaga ataagagggt agaattgccc tataatcaag ataaactaag attttggagg
    31501 aaaaatgagt aatatcagtt taacaacact tggtggtgtg cgtgagaatg gaaaaaatat
    31561 gtacattgct gaaattggag agtccatttt tgttttgaat gtagggttaa aatatcctga
    31621 aaatgaacaa ttaggggtcg atgtggtgat tccaaacatg gattaccttt ttgaaaatag
    31681 cgaccgtatt gctggggttt tcttgaccca cgggcatgcg gatgccattg gtgctctacc
    31741 gtatctcttg gcagaggcta aagttcctgt atttgggtct gagttgacca ttgagttggc
    31801 aaagctcttt gtcaaaggaa atgatgccgt taagaaattt aatgatttcc atgtcattga
    31861 tgagaatacg gagattgatt ttggtgggac agtggtttcc ttcttcccta cgacttactc
    31921 cgttccagag agtctgggaa ttgtcttgaa gacatcggaa ggaagcatcg tttatacagg
    31981 tgacttcaaa tttgaccaaa cggctagtga atcttatgca actgattttg ctcgtttggc
    32041 agagattggt cgtgacggcg tcctggctct cctcagtgat tcggccaatg cagacagcaa
    32101 tattcaggtg gctagtgaaa gtgaagttag ggatgaaatt acccaaacta ttgctgactg
    32161 ggaaggtcgt atcatcgttg cagctgtttc cagtaatctt tctcgtattc agcagatttt
    32221 tgacgctgcg gataaaacag gtcgacgtat cgtcttgaca ggatttgata ttgaaaatat
    32281 cgtccgcaca gcgattcgtc ttaagaagtt gtctttagcc aacgaaattc ttttgattaa
    32341 gcctaaagat atgtctcgct ttgaagacca tgagttgatt attcttgaga caggtcgtat
    32401 gggtgagcct atcaatggac ttcgtaagat gtcgattggt cgccatcgtt atgtagaaat
    32461 caaggatggg gacctagtct atattgctac ggctccgtct attgctaaag aagcctttgt
    32521 tgcgcgtgtg gaaaatatga tttatcaggc aggtggggtt gtcaaattga ttacccaaag
    32581 tttacatgta tcagggcacg gaaatgtgcg tgatttgcag ctgatgatca atcttttgca
    32641 acctaagtac ctcttccctg tccaagggga gtatcgtgag ttggatgctc acgctaaggc
    32701 tgccatggca gttgggatgt tgccagaacg catcttcatt cctaaaaagg ggacgaccat
    32761 gtcttacgag aatggagact tcgttccagc tggatcggtt tcagcaggag atatcttgat
    32821 tgatgggaat gccattggtg atgttggaaa tgttgttctt cgtgaccgta aggtcttgtc
    32881 agaggatgga attttcatcg tggctattac agtcaaccgt cgtgagaaga aaattgtggc
    32941 tagggctcgt gttcacacgc gtggatttgt ttatctcaag aagagtcgcg atattctccg
    33001 tgaaagttca gaattgatta accaaacggt agaagagtat cttcaaggag atgactttga
    33061 ctgggcagat ctcaaaggta aggttcgtga caatctgacc aagtacctct ttgatcaaac
    33121 caagcgtcgc ccagccattt taccagtagt catggaagca aaataatcgt tgaaataaac
    33181 agagagaaag tcgagtttcg gctttttctt atagaaaaat agaaggagaa aatcatggca
    33241 gtaatgaaaa tcgagtatta ctcacaagta ttggatatgg agtggggggt gaatgtcctc
    33301 taccctgatg ccaatcgagt ggaagaacca gagtgtgaag atattcccgt cttgtacctt
    33361 ttgcacggga tgtctggaaa tcataatagt tggcttaagc ggaccaatgt agaacgcttg
    33421 cttcgaggaa ctaatctcat cgttgttatg cccaatacca gcaatggttg gtacaccgat
    33481 acccagtatg gttttgacta ctacacggct ctagcagagg aattgccaca ggttctgaaa
    33541 cgcttcttcc ctaatatgac gagcaagcgt gaaaagacct ttatcgctgg tctttctatg
    33601 ggaggctacg gctgcttcaa actggctctt acgacaaatc gtttttctca tgcagctagt
    33661 ttttcaggtg ccctcagctt tcaaaacttt tctcctgaaa gtcaaaatct gggaagtcca
    33721 gcctactgga gaggtgtttt tggagagatt agagactgga caactagtcc ctattctctt
    33781 gaaagtctgg ctaaaaaatc ggataaaaag accaaacttt gggcgtggtg tggcgaacag
    33841 gatttcttgt acgaagccaa taatctcgca gtgaaaaatc tcaaaaaact aggttttgat
    33901 gtgacctata gccatagtgc tggaactcac gagtggtact actgggaaaa acaattggaa
    33961 gtttttttaa caaccctacc aattgatttc aaattagaag agagactgac ttagtttgaa
    34021 cttcagcata gggggagtag aactaaaata aaatatgttt tcactagact tttcaaacga
    34081 aagtagtaga atagtaataa aatactggag gaaagagagt aggaaatgta ccgttatcaa
    34141 attggcattc ccacattaga atatgatcag tttgttaaag aacatgaatt agccaatgta
    34201 ttacaaagta gtgcttggga ggaagttaag tctaattggc aacatgagaa gtttggtgtt
    34261 tacagggaag aaaaattact ggcgacagct agtattttga ttagaactct tccgctaggc
    34321 tataaaatgt tttacatccc aagaggacct atattggatt atggggataa agaactcttg
    34381 aattttgcca ttcagtctat taagtcctat gctcgcagta agagagcagt ttttgtgact
    34441 tttgacccaa gtatttgcct atctcaaagt ttaatcaatc aggaaaagac agaatttcct
    34501 gaaaatctgg ctattattga tagtttgcaa caaatgggag taaggtggtc aggaaaaacg
    34561 gaggaaatgg gagacaccat tcaacctcgt attcaggcga aaatatacaa ggaaaatttt
    34621 gaagaagata aactttccaa gtcaacaaaa caggctattc gaacagcacg aaacaaaggg
    34681 cttgagattc aatatggtgg actggaacta ttagattcat tttcggagtt gatgaaaaaa
    34741 actgagaagc gaaaagagat tcatttgagg aatgaagcct attataaaaa attgttagat
    34801 aattttaagg acaaggccta tatcaccttg gccaccttgg atgtttctaa acgttcgcaa
    34861 gagttagaag aacagttagc gaaaaataga gccttggaag agacctttac tgagtcgact
    34921 cgaacttcaa aagtagaagc gcagaagaag gaaaaagaac gtttgttaga ggaattgacc
    34981 ttcttgcagg aatatataga tgtaggtcaa gcgagagttc ctttagcggc tactttgagt
    35041 ttggaatttg gtactacctc tgtcaatata tatgctggta tggatgatga ttttaaacgt
    35101 tacaatgcac caattttaac atggtatgaa acggctcgct atgcctttga gcgaggtatg
    35161 gtctggcaaa atttaggtgg tgttgaaaac tctctcaatg gtggacttta tcattttaag
    35221 gaaaaattta atccaacgat tgaagaatac ttgggtgaat ttacaatgtc cactcatcct
    35281 ctctatcctc tgttaagact tgctcttgat ttccgtaaaa cattaagaaa aaaacataga
    35341 aagtaagtat atggcactaa caacactcac gaaagaagag tttcagactt attctgatca
    35401 ggtttcttct cgttccttta tgcaatctgt ccagatgggg gatttgctag aaaaaagagg
    35461 ggctcgaatt gtttatcttg ctttgaaaca agaaggagaa attcaagttg cagctctggt
    35521 ttatagcttg cccatgctgg gtggtctgca tatggaactc aattcggggc cgatttatac
    35581 ccaacaagat gctcttccag ttttttatgc agagttaaaa gaatatgcca agcaaaatgg
    35641 tgtattagag ttgcttgtaa aaccttatga aacttatcaa acttttgata gccaaggtaa
    35701 tccaatagat gctgagaaaa aaagtattat tcaaggtttg actgatttag gttatcaatt
    35761 tgatggctta acaacaggtt acccaggtgg agaaccagat tggttatact ataaagattt
    35821 aactgaatta actgaaaaga gtttgcttaa aagttttagc aaaaagggta aacccttggt
    35881 gaaaaaggct gaaacctttg gcattcggtt gaaaaagtta aaacgtgaag aactatcgat
    35941 ttttaagaat ataacaaaag aaacctctga acgtagagaa tatagtgata aaagtttaga
    36001 atattatgag catttttatg atacttttgg agaacaagcg gagtttctca tagcaagctt
    36061 gaatttttcg gagtatatga gcaaattgca aggtgaacaa agtaaactag aagaaaactt
    36121 ggacaagttg cgacttgatt tgagtaaaaa tcctcattct gaaaaaaaac aaaatcaact
    36181 gagagaatat tctagtcaat ttgaaacgtt tgaagttcga aaagcagaag cgcgagactt
    36241 gattgaaaaa tatggagaag aagatattgt tttagctggg agtttatttg tttatatgcc
    36301 tcaggaaacg acttatctct ttagtggttc ctacactgag tttaataagt tctatgcccc
    36361 tgccctgctt caaaaatatg ttatgttgga aagcataaaa cgtggaatac ctaaatacaa
    36421 cttcctaggc attcaaggga tttttgatgg aagtgatggt gttttgcgtt ttaaacagaa
    36481 ttttaatggc tatattgtac gcaaagcggg tactttccgt taccatccat cgcctttaaa
    36541 atacaaagct atccagttac tcaaaaaaat agtaggacgt taagatgaaa aagtcagtat
    36601 ttagatttct tttagcttct tttagtaaaa taattcttat ttgctagaaa ggtggagaga
    36661 catgcgctgg ctttttcgtt tgataggggc tttcttttct tttgtgtggc gtttgttttg
    36721 gcgtctggtt tggatagttg tgctcttatg tgtgcttgct ttcggacttc tctggtatct
    36781 gaacggggat tttcaaggag cgctaaagca agcagaacgg tcagtaaaaa ttggtcaaca
    36841 aagtattgac caatgggaga aaacagggca actgcctaag ttaagccaga cagatagtca
    36901 ccagcattct gaaggaaggt gggcacaggc ctctgctcgt atttacctgg atccgcagat
    36961 ggattcacgc tttcaagagg cttatttaga agcaatccag aactggaatc aaactggtgc
    37021 ttttaacttt gaactcgtga ctgagtctag taaggcggat attacggcta cggagatgaa
    37081 cgacggaggc actcctgtgg caggagaggc ggaaagtcaa actaatctct taacagggca
    37141 attcttgtcc gtaacggtgc ggttgaatca ttattatttg tccaatccat actatggcta
    37201 ctcctatgaa cgccttgtcc atacggcaga acatgagtta ggtcatgcga ttggcttgga
    37261 ccatacagat gagaagtctg tcatgcaacc agcaggttcc ttttatggta tccaggaaga
    37321 ggatgttgca aacctccgaa aaatatatga gactagtgag tagggtacta tctttcccta
    37381 ctttttttgc tataatggaa ctatgaacaa cttgattaaa tcaaaactag agctcttgcc
    37441 gaccagccct ggttgctaca ttcataagga taaaaatggc accattatct atgtaggaaa
    37501 ggctaaaaat ctgcgtaatc gagtacggtc ctattttcgt ggaagtcatg ataccaagac
    37561 agaggctctg gtgtctgaaa ttgtggattt tgaatttatt gttacggagt ctaatattga
    37621 ggcacttctc ctagaaatca acctgatcaa ggaaaacaag cccaagtaca atatcatgct
    37681 caaggatgac aagtcctatc cttccatcaa aatcaccaat gagcgctatc cacgcttgat
    37741 tatcactcgt caggtcaaaa aggacggagg tctttatttt ggaccctatc ccgatgtggg
    37801 ggcagccaat gaaatcaagc ggttgctgga tcggatattc ccttttcgta agtgtaccaa
    37861 cccgccctct aaggtctgtt tttattacca tatcggtcaa tgcatggccc acaccatctg
    37921 taagaaggat gagacttatt tcaagtctat ggcccaggag gtttctgatt ttctgaaagg
    37981 gcaggataac aaaatcattg atgagctaaa gggcaaaatg gcagcggcag cccagactat
    38041 ggagtttgaa cgtgcggcgg aataccgtga cctgattcag gctattggaa cgcttcgaac
    38101 caagcaacgg gtcatggcta aggatctcca aaatcgcgat gtctttggct actatgtgga
    38161 taagggctgg atgtgtgtgc aggttttctt tgtccgtcag ggtaagctca tcgagcgcga
    38221 tgtcaatctc ttcccctact tcaatgatcc agatgaggat tttttgacct atgtaggaca
    38281 attctatcaa gaaaaatctc acctagttcc caatgaggta ctgattccgc aggatattga
    38341 cgaagaagct gtcaaggctt tggtggatac caagattctc aaaccccaac gtggagagaa
    38401 aaaacagctg gtcaatctag ccataaaaaa tgcacgtgtt agtctggagc agaaatttaa
    38461 cctgctagag aaatctgtcg agaagaccca aggagctatt gaaaatctag gacgtttgct
    38521 ccaaatcccg accccagtac gtatcgagtc cttcgataac tctaatatca tgggaactag
    38581 ccctgtttcg gctatggtgg tctttgtcaa cggtaaaccg agtaagaagg attaccgcaa
    38641 gtacaagata aaaacggttg ttggaccaga cgactatgcc agcatgagag aggtcattcg
    38701 cagacgctat ggtcgagtac agcgtgaggc tttgactcct ccagatttga ttgtgattga
    38761 tggggggcaa ggtcaagtca atatcgctaa gcaggttatc caagaggaac tgggcttgga
    38821 tattccaatt gctgggctgc aaaagaatga taagcaccaa acccatgaac tgctctttgg
    38881 agatccgctt gaggtggtgg acttgtctcg caattctcag gaatttttcc tcctccaacg
    38941 catccaagat gaggtgcacc gctttgccat taccttccac cgccaactgc gctccaaaaa
    39001 ttctttctca tctcaattgg atgggattga tggtctggga cctaaacgca agcaaaatct
    39061 catgaggcac ttcaagtctc tgaccaaaat caaggaagcc agtgtggatg agattgtcga
    39121 agttggagta ccaagagcag tagcagaggc tgtgcaaaga aagttgaacc cgcagggaga
    39181 agccttgcct caagtagcag aagaaagagt agattaccaa acggaaggaa accacaatga
    39241 accataaaat cgcaatttta tcagatgttc atggcaatgc gacggcgcta gaagcagtga
    39301 ttgcagatgc taaaaatcaa ggggccagtg aatattggct tctgggagat atttttcttc
    39361 ctggtccagg cgcaaatgac ttagtcgccc tgctaaagga ccttcctatc acagccagtg
    39421 ttcgaggcaa ttgggatgat tgtgtcctgg aggtcttgga tgggcaatac ggtttggaaa
    39481 atccgcaaga aatccagctc atgcgaatga ctcagttttt gatggagcga atggatcctg
    39541 caacgactgt ctggctacga agcttgcctt tgctggaaaa gaaagaaatt gctggactgc
    39601 gcttttctat ctctcataat ttgccaaata agaactatgg tggtgacttg ctagttgaga
    39661 atgatacaga gaaatttgac caactgctag atgcggaaac ggacgtggca gtttatggtc
    39721 atgttcacaa gcagttgctt cgttatggaa gtcaagggca acaaatcatc aatccagggt
    39781 cgattggcat gccctatttt aattgggagg cgttaaaaaa tcaccgtgcc cagtatgccg
    39841 tgatagaagt tgaagatggg gaattggtca atatccaatt tcgtaaagtt gcttatgatt
    39901 acgaggctga gttagaattg gccaagtcca aggggcttcc ctttattgaa atgtatgaag
    39961 aactgcgtcg tgacgataac tatcaggggc acaatctgga acttttagcc agcttaatag
    40021 aaaagcatgg gtatgtagag gatgtgaaga atttttttga ttttttgtaa gagtttccta
    40081 aaatagccaa tgcaaactaa aaaagcgatt ggctggtcca atcgctttta gtatatctta
    40141 tactcaatga aaatcaaaga gcaaactagg aagctagccg taggttgctc aaagcacagc
    40201 tttgaggttg cagataaagc tgacgtggtt tgaagagatt ttcgaagagt gttattgtaa
    40261 ctgagattga tctgggaggt aagaaccacc tagataggta ttgctgagtt tttcaagggt
    40321 tccgtcttga tagagttctt tgagcgcttt atcaaattgc tctttaaact ctttttggtc
    40381 gcttgagaaa atgatataat tgctggggct atctgcagaa ggtaaatcaa cgactgagag
    40441 gtctaaacca cggtccttga taatcttttg aacggatacc ttgtcaaaaa ctaggaaatc
    40501 aaactctccg ttagcaaggt ctaggattcg tttaccaata tcctcaccag aaaaattaat
    40561 tgtagcggga ttatcagtgt gtttctgatt ccagttattg atgaattgag cgttagaagt
    40621 tccggtatcc tcttgtgttg ttttaccagc gatctggtca agagaagtca aaggattttt
    40681 cttgttgctg acaaggacga ggggattgtt ggaaatcgga agcgagtaaa ggtatttttc
    40741 agcacgctct tttgtgtaac tcaaattatt ggccgcagcc tgatagtgac cagaatcaag
    40801 tcctgggaag atactttccc aggcggttct ttgaaattga atctcgtagt cgctgagttt
    40861 ttcatctact gcctttagaa cttcgatatc gaagcctgtc agattgcctt tatcttcgta
    40921 gtcaaatggt ggcacgtcgc cagctgtagc aaggacgatt gtcttttgag cgctagtctc
    40981 tttgggtgta gcttgattcc cacaggcaac caaaaatggt aggatagcta gtaataggct
    41041 aaattttttc atactgtctc cattcaaatg taaagtactt gctagtttat cagaaacttt
    41101 cctgataaac caatatatat cttttatgtc tgtgatagaa aaacttaatc atgaaaaatc
    41161 cctgcaagct ctttcaaatt atggtagaat ggaagcagta gaattagaaa aggaaatcga
    41221 ttatgaaatt tcttgaatta aataaaaaac gtcatgcgac caagcatttc actgataagc
    41281 ctgttgatcc aaaagatgtg cgtacggcta tcgaaattgc aaccttggcg ccaagcgccc
    41341 acaacagcca gccttggaaa tttgtagttg ttcgtgagaa aaatgctgaa ctggcaaagt
    41401 tggcttatgg ttcaaacttt gagcaggtat catcagcacc tgtaaccatt gccctattta
    41461 cagatacaga ccttgccaaa cgcgctcgta agattgcccg agttggtggt gctaacaatt
    41521 tctcagaaga acaacttcaa tacttcatga aaaatttgcc agctgaattt gcacgctaca
    41581 atgaacaaca agtcagcgac tacctagcac tcaatgcagg tttggttgct atgaacttgg
    41641 ttctcgctct tacagaccaa ggaattggtt ccaatattat ccttggtttt gacaaatcaa
    41701 aagtcaatga ggttttggaa attgaagacc gtttccgccc agaactcttg atcacagtgg
    41761 gttacacaga cgacaaattg gaaccaagct accgcttgcc agtagatgaa atcatcgaaa
    41821 aaagatagga agaagaaaaa atgatagcaa ttgattttac agcagaagta gaaaaacgca
    41881 aagaagacct cttggctgac ttgtttagcc ttttggaaat caactcagaa cgtgatgata
    41941 gcaaggctga tgcccaacat ccatttggac ctggtccagt aaaagccttg gaaaaattcc
    42001 ttgaaatcgc agaccgtgat ggttatccaa ctaagaatgt cgataactac gcaggacatt
    42061 ttgagtttgg tgatggagaa gaagttctcg gaatctttgc ccatatggac gtggttccag
    42121 ctggtagcgg ttgggataca gatccttaca caccaactat caaagatggt cgcctttatg
    42181 cgcgcggggc ttcggacgat aagggtccta caacagcttg ttactatggt ttgaaaatca
    42241 tcaaagaatt gggtcttcca acttctaaga aagttcgctt catcgttgga acagacgaag
    42301 aatcaggctg ggcagacatg gactactact ttgagcacgt aggacttgcc aaaccagatt
    42361 tcggtttctc accagatgct gaatttccaa tcatcaatgg tgaaaaagga aatatcacgg
    42421 aatacctcca ctttgcagga gaaaatacag gtgctgcccg tcttcacagc tttacaggtg
    42481 gtttacgtga aaatatggta ccagaatcag caacagcagt cgtttcaggt gatttggctg
    42541 acttgcaagc taaactagat gcctttgttg cagaacacaa acttagagga gaactccaag
    42601 aagaagctgg caaatacaag gtgacgatca ttggtaaatc agcccacggt gctatgcctg
    42661 cttcaggtgt caatggtgca acttaccttg ccctcttcct cagccagttt ggctttgctg
    42721 gtccagccaa agactacctt gacatcgcag gtaaaattct cttgaacgat catgagggtg
    42781 aaaatctcaa gattgctcat gtggatgaaa agatgggtgc tctttctatg aatgccggag
    42841 tcttccgctt cgatgaaaca agtgctgata ataccattgc ccttaacatc cgctatccaa
    42901 aaggaacaag tccagaacaa atcaaatcaa tcctagaaaa cttgccagtt gcttctgtca
    42961 gtctatcaga acatggtcat acccctcact atgtgccaat ggaagatcca cttgtgcaaa
    43021 ccttgttgaa tgtctatgaa aaacaaacag gcctacaagg tcatgaacaa gtcatcggtg
    43081 gtggaacctt tggtcgcttg ttagagcgcg gagttgccta tggtgctatg ttcccagact
    43141 caattgatac catgcaccaa gccaatgaat ttattgcctt ggacgatctc ttccgagcag
    43201 cagcaattta tgccgaagct atttacgaat tgatcaaata aaacgataga agtctgagat
    43261 cttatgcttg gacttctttt tggagggaaa gtagatgtct caaatcgaaa gaatcaaaca
    43321 ggctatcatg gcggattcgc agaatgccag ctatacagag cgtggcattg agcctctctt
    43381 tgcagcgcca aaaactgctc gcatcaatat catcggtcag gctccgggac ttaaaactca
    43441 agaagcaggc ctttactgga aagataaaag tggtgaccgc ttgcgggact ggctaggtgt
    43501 ggatgaagat accttttaca attcaggtta ttttgctgtt ttgcctatgg atttctactt
    43561 tccaggacat ggcaagtcgg gtgatcttcc gcctcgtaca ggttttgcag aaaaatggca
    43621 tccgcagctc ttacaggaat tgcctgatat tcagttaacc ctcttgattg ggcaatatgc
    43681 ccaagcctac tatttacagg agaaaatcag tgggaaggta acggagaggg tgaaacacta
    43741 taaagactat ctgccagcct attttccgct agttcaccca tcaccacgaa atcaaatctg
    43801 gatggccaaa aatccttggt ttgaggcaga agtagtgcca gatttgaaaa aaagaattaa
    43861 aaccatttta tagtcaatga aaatcaaaga gcaaactagg aagctagtcg taggctgctc
    43921 aaagtacagc tttgaagttg cagataaaac tgacgaagtc ggtaacatac gcacggtaag
    43981 gcgacgctga cgtggtttga agagattttc gaagagtatt agaagaaaaa gaatgaaaga
    44041 aatagccttt gacgcatttt accagcttta ccaaaacgac cagctttctt tagtggatgt
    44101 gagagaagtg gatgagtttg cagctcttca tttagaaggt gcccacaacc taccgcttag
    44161 tcaattggct gatagttatg attaattgga caaagatcgc ttgcattata ttatttgcaa
    44221 atctggaatg agatcggcgc gtgcttgcca attcctatta gaacaaggtt ataatgttat
    44281 caatgtccag ggtggcatgt tagcctttga agaactttaa aattttgcat ttctcctact
    44341 tggtgtggac tgggtaggag agttttattt ttagataatt cttattttta agaaaattga
    44401 aaacatttaa tatttgcctc gtgatgcttt tttcagactc ctaatcgtgg tatactaggt
    44461 cagtatttta taaatatgaa ggagattttt atggctaaaa aaggtaccct aacaggtttg
    44521 ctcctgtttg gaatattttt tggtgcgggg aacttgattt ttccgccttc tctaggtgct
    44581 ctatctggag aacattttct tcctgccatc gcaggttttg tcttttcagg cgttggtatc
    44641 gccgtcttga cccttattat tggaacgcta aatcctaaag gatatatcta cgagatttca
    44701 acgaagatag cgccttggtt tgcgactctt tacctctcag ttctttactt gtcaatcggt
    44761 ccattctttg ctaccccacg tactgctaca acagcttacg aagtagggat tagccccctt
    44821 ttgtcggatg caaataaagg acttggcttg attgtattta cggttctgta ttttgcggca
    44881 gcctatttga tttcgcttaa tccatcaaaa atcttagacc gcattggacg tattttaacg
    44941 ccagtctttg caattttgat tgttatcttg gtcgttctgg gagctatcaa atatggtgga
    45001 acaagtcctc aagctgcttc agctgcttat caagcttctg cctttggtac aggtttccta
    45061 gaaggttaca ataccttgga cgcccttgcc tcagtggcct ttagcgtaat cgcagttcaa
    45121 accttgaaac aacttggatt ttcaagtaag aaagaataca tttcaactat ttgggttgtt
    45181 ggtatcgttg ttgcccttgc cttcagcgct ctttacatcg gtttaggttt tcttggaaat
    45241 catttcccag taccagctga agcgatgaag ggtggaacac caggtgttta catcttgtca
    45301 caagccactc aagaaatctt tggctcaaca gctcaactct tccttgcagc tatggttacc
    45361 gtaacctgct tcacaacgac tgttggtttg attgtgtcaa cagctgagtt ctttaatgag
    45421 cgcttcccac aaatcagcta caaggtttat gcgacagcct ttaccttgat tggatttgct
    45481 attgccaatt tgggtcttga tgcgattatc aagtactcaa ttccagtact ggttatcttg
    45541 tacccaatca cgattgctat cgttatgatt gtcattgtca acaaatttgt tgccctttca
    45601 aaaccaggta tgcagttgac aattgctgtg gttacagtta ttgccattgc aagcgtacta
    45661 ggaagctcgt ttaaggttga gtttcttgca aatcttgtta gcgttcttcc ttttgccaag
    45721 gcatctctcc catggttggt gccagccatt gttggaatct tgctctcatt ggttctacca
    45781 aacaagcaag aaagcgatgt ttttgaaatg gaataatcac ttagatcact tttgtagcca
    45841 agtctacagg agtgattttc tttttttatc cgatgataaa tgtgttataa taggtagcga
    45901 aagaggtgaa gaaatgaatc aaacagtaga atatatcaaa gaactgacag ccatcgcatc
    45961 gccaacgggc ttcactcgtg aaatttcgaa ttatttagtc aagactctag aaggttttgg
    46021 ttaccagcca gttcgcacag ccaagggtgg tgtcaatgtg accatcaaag gtcaaaatga
    46081 tgagcaacat cgctatgtga ctgcccatgt ggacacgctg ggtgctattg ttcgtgctgt
    46141 caaaccagat ggtcgtctta aattggaccg tatcggtggt tttccttgga acatgattga
    46201 aggtgaaaac tgtaccgttc atgtggctag cacaggtcaa aaggtatcag gaaccatcct
    46261 catccaccaa acttcttgcc atgtctacaa ggatgcagga actgcagaac gcacgcagga
    46321 caatatggaa gtgcgtttgg atgtaaaagt aagcaatgaa aaagaaactc gtgctcttgg
    46381 gattgaggtc ggtgatttta tcagcttcga tccacgaact gttgtgactg atacaggttt
    46441 tatcaagtct cgtcatttgg atgataaggt cagcgcagcg attttgctca acctgcttcg
    46501 tatttataag aaagagaaga ttgaattgcc agtaacaact cattttgctt tttcagtttt
    46561 tgaagaagta ggacatggtg ctaattctaa cattcctgct caggtagtcg aatatctggc
    46621 tgttgatatg ggagctatgg gcgatggcca gcaaacagat gagtacacag tgtctatctg
    46681 tgtcaaggat gcctcaggcc cttatcacta tgacttccgt caacacttgg tgaccttggc
    46741 gaaagagcaa aatattcctt ttaagctgga catctatcca ttttatggtt cggatgcttc
    46801 agcggccatg tccgcagggg cagaggtcaa acacgccctc cttggcgcgg gtatcgagtc
    46861 tagtcattct tatgagcgta ctcatattga ctcggtggtc gcaacagagc gtatggttga
    46921 tgcttacatt aagagcgcgt tggtagacta atatgtgtct tatatgccag agaattgagc
    46981 tcatcaagaa gggagaaaat ccctattttg tcaaagagtt ggaaacaggc tatcttgtga
    47041 ttggagatca ccagtatttt gcaggctata gtctctttct agccaaggaa cacgtcacgg
    47101 aattgcacca tttagaaaag gaaacaagac tacgttttct cgaagaaatg agtctaatcc
    47161 aagaggcagt tgctaaggcc tttactgctg agaaaatgaa tattgaactt ttaggaaatg
    47221 gcgatgccca tcttcattgg catctgtttc cacgacggac aggtgatatg aatggtcacg
    47281 gtctcaaggg acgtggtcca gtttggtggg ttccttttga agaaatgaca gcagaaacct
    47341 gccaagcaaa accggatgag atcaaaagat tagtcaaacg tttatcatca gaagtagata
    47401 aactattaga aataaaggag tagaaatgaa gaaaagatac cttgtcgtga cagccttgct
    47461 agccttgagt ctagcagctt gttcacaaga aaaagcaaaa aatgaagatg gcacagctaa
    47521 gacagaacag acagccaaag ctgatgggac agtcggcagt aagtctcaag gggctgccca
    47581 gaaaaaagca gaagtggtca ataaaggtga ttactacagc atccaaggaa aatacgacga
    47641 aatcatcgta gccaataaac attatccttt gtcgaaagac tataatcccg gggaaaatcc
    47701 aacagccaag gctgagttgg tcaaactcat caaagcgatg caagaggcag gtttccctat
    47761 tagtgatcat tacagtggtt ttagaagtta tgaaactcag accaagctct atcaagatta
    47821 tgtcaaccaa gatggaaagg cagcagctga ccgttactct gcccgtcctg gctatagcga
    47881 acaccagaca ggcttggcct ttgatgtgat tgggactgat ggtgatttgg tgacagaaga
    47941 aaaagcagcc caatggctct tggaccatgc agctgattat ggctttgttg tccgttatct
    48001 caaaggcaag gaaaaggaaa caggctatat ggctgaggaa tggcacctgc gttatgtagg
    48061 aaaagaagct aaagaaattg ctgcaagcgg tctcagtttg gaagaatact atggctttga
    48121 aggcggagac tacgtcgatt aatactcttc gaaaatctct tcagaccacg tcagcgtcgc
    48181 cttacctact gactgcgtcg gttctattca caacctcaaa acagtgtttt gagctgactt
    48241 cgtcagtttt atctgcaacc tcaaagctgt attttgagca gcctgcggct agcttcctag
    48301 tttgctcttt gattttcatt gagtataaaa aataaacttt tctcttgcaa ttccagataa
    48361 atagtgtata atggatgggt atgtgaaaaa catacttgtg ggaggtaaaa atctctaatt
    48421 accgccaaaa ccacaaagga ggatttaaaa atggctaaaa aagtcgaaaa acttgtaaaa
    48481 ttgcaaatcc ctgctggtaa agctacacca gctccaccgg ttggacctgc tcttggtcaa
    48541 gctggtatca acatcatggg attcacaaaa gagttcaacg ctcgtacagc tgaccaagct
    48601 ggtatgatca ttccagttgt tatctcagtt tacgaagata aatcatttac tttcgttacg
    48661 aaaacaccac cagctgctgt tcttttgaaa aaagctgcag gtgttgaaaa aggatcaggt
    48721 acacctaata aaactaaagt tgctacagtt actcgtgcac aagtacaaga aattgcagaa
    48781 actaagatgc cagatttgaa cgcagcaaac gtagagtctg caatgcgtat gatcgaaggt
    48841 actgctcgtt ctatgggatt cactgttgtt gactaatcaa taacacagta gaaaatctca
    48901 cagcagtcta ttagttgctt ttcatactag gcaagtgact gaggcttgta cttgggtaca
    48961 gcaagggagc ttaaggccgt aggaagagaa aaatagtaga ctgaaaaccc gcaagacttc
    49021 atcatttcga gaagtgacgt gggagatgaa aatcgattga accacttaca aggagaatag
    49081 aaaatggcta aaaaaagcaa acaacttcgt gctgctcttg agaaaatcga cagcacaaaa
    49141 gcatacagtg tagaagaagc tgtagcactt gcaaaagaaa ctaactttgc aaaatttgat
    49201 gcaactgtag aagttgctta caacttgaac atcgacgtta aaaaagctga ccaacaaatc
    49261 cgtggagcaa tggtattgcc aaacggtact ggtaaaactt cacgtgttct tgttttcgca
    49321 cgtggtgcaa aagctgaaga agcaaaagct gctggtgcag actttgttgg tgaagatgac
    49381 cttgttgcta aaatcaacga cggttggttg gacttcgacg tagttatcgc tacacctgat
    49441 atgatggctc ttgttggacg tcttggacgt gtccttggac cacgtaactt gatgccaaac
    49501 cctaaaactg gtactgtaac aatggatgtt gctaaagcag ttgaagagtc taaaggtggt
    49561 aaaatcactt accgtgctga ccgtgcaggt aacgttcaag caatcatcgg taaagtatca
    49621 tttgaagctg aaaaattggt tgaaaacttt aaagctttca acgaaacaat ccaaaaagca
    49681 aaaccagcta cagctaaagg aacttacgta acaaacttga ctatcacaac tactcaaggt
    49741 gttggtatca aagttgacgt aaactcactt taatcagtag ttaaagtaat gtaaaaaagt
    49801 tgaagacgct atgtctcaac tttttttgat gtacgacggg catgttgtat agtagattga
    49861 aactagaata gtacacatct acttctaaaa cattgttaga aattgatttg actgtcctga
    49921 tcgattcgtc ctattcttat ttcattttat tatatatttg aggtgtaagt cctcggtggg
    49981 cacctgctac cggtgaaccc aatagcgatt cccaagtctg actatcgtga ggtagcggat
    50041 taaaacggtc tggggataga ccgttttaag tctgacgctg gaaataagaa tcgtcagagg
    50101 aagggatagc gaaatcgtgg ctctacgaac aggaacgtga taataaggcc tatatagcgg
    50161 ataaggtatc tggctggggc gaccactatc aattagtagc tcagaagtcg gtacttaaac
    50221 gtgctatatc aaaaccagtc cttgaaaaac gtggactggt ttcgtgtttg gattattacc
    50281 ttgaatgaca tgcgttaaca gttagttgaa ccgccgtatg ccgaacggca cgtacggtgg
    50341 tgtgagaggg gctagagatt atcccctact cgatttcgaa atctagtgga atgaatctgg
    50401 aatagtccat cgagctttct aatactcttc gaaaatctct tcaaaccacg tcaacgtcgc
    50461 cttgccgtgc gtatggttac tgact
//
LOCUS       DAVLHC010000010        49046 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.010, whole genome shotgun sequence.
ACCESSION   DAVLHC010000010 DAVLHC010000000
VERSION     DAVLHC010000010.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 49046)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 49046)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..49046
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.010"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(367..1347)
                     /locus_tag="VXE25_000612"
     CDS             complement(367..1347)
                     /locus_tag="VXE25_000612"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetylxylan esterase"
                     /protein_id="HEV0771124.1"
                     /translation="MKNSALLEEIKTYRGRDEVPEDFDAFWDGEVKNVSTLPSYHLEE
                     RDFHIPQVKCYELTFEGSKEGKVYARIVLPKSEEKVPLIFHFHGYMGRGWDWADMLGF
                     TVAGYGVVSMDVRGQSGYSQDGLRSPLGNTVKGHIIRGAMEGRDHLFYKDVYLDIYQL
                     VEIVASLSQVDEKRLSSYGASQGGALALVAAALNPRIQKTVAIYPFLSDFRRVIEIGN
                     TSEAYDELFRYFKFHDPFHETEEEIMATLAYIDVKNLAHRIQGEVKMITGLDDDVCYP
                     ITQFAIYNRLTCDKTYRIMPEYAHEAMNVFVNDQVYNWLCGSEIPFKYLK"
     gene            complement(1674..1877)
                     /locus_tag="VXE25_000613"
     CDS             complement(1674..1877)
                     /locus_tag="VXE25_000613"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771125.1"
                     /translation="MKIKEQTRKLTAGCSKHCFEVVDETDEVSSKHCFEVADRTDEVS
                     SKHCFEVADRTDEVSNIYTVRRR"
     gene            complement(1905..3920)
                     /gene="recG"
                     /locus_tag="VXE25_000614"
     CDS             complement(1905..3920)
                     /gene="recG"
                     /locus_tag="VXE25_000614"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001048793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent DNA helicase RecG"
                     /protein_id="HEV0771126.1"
                     /translation="MNLHQPLHVLPGVGPKSAEKYAKLGIENLQDLLLYFPFRYEDFK
                     TKQVLELEDGEKAVLSGQVVTPASVQYYGFKRNRLRFSLKQGEVVFAVNFFNQPYLAD
                     KIELGATLAVFGKWDRAKASLTGMKVLAQVEDDLQPVYRLAQGISQASLVKVIKTAFD
                     QGLDLLIEENLPQSLLDKYKLMSRCQAVRAMHFPKDLAEYKQALRRIKFEELFYFQMQ
                     LQTLKSENRVQGSGLVLNWSQEKVTAVKVSLPFALTQAQEKSLQEILTDMKSDHHMNR
                     LLQGDVGSGKTVVAGLAMFAAVTAGYQAALMVPTEILAEQHFESLQNLFPNLKLALLT
                     GSLKAAEKREVLQTIAKGEADLIIGTHALIQDGVEYARLGLIIIDEQHRFGVGQRRIL
                     REKGDNPDVLMMTATPIPRTLAITAFGDMDVSIIDQMPAGRKSIVTRWIKHEQLPQVL
                     TWLEGEIQKGSQAYVISPLIEESEALDLKNAIALSEELTTHFACKAEVALLHGRMKSD
                     EKDQIMQDFKERKTDILVSTTVIEVGVNVPNATVMIIMDADRFGLSQLHQLRGRVGRG
                     DKQSYAVLVANPKTDSGKDRMRIMTETTNGFVLAEEDLKMRGSGEIFGTRQSGLPEFQ
                     VADIIEDFPILEEARKVASYISSIEAWQEDPEWRMIALHLEKKEHLD"
     gene            complement(3939..5042)
                     /locus_tag="VXE25_000615"
     CDS             complement(3939..5042)
                     /locus_tag="VXE25_000615"
                     /EC_number="5.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000648075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine racemase"
                     /protein_id="HEV0771127.1"
                     /translation="MKASPHRPTKALIHLGAIRQNIQQMGAHIPQGTLKLAVVKANAY
                     GHGAVAVAKAIQDDVDGFCVSNIDEAIELRQAGLSKPILILGVSEIEAVALAKEYDFT
                     LTVAGLEWIQALLDKEVDLTGLTVHLKIDSGMGRIGFREASEVEQAQDLLQQHGVRVE
                     GIFTHFATADEESDDYFNAQLERFKTILASMKEVPELVHASNSATTLWHVETIFNAVR
                     MGDAMYGLNPSGAVLDLPYDLIPALTLESALVHVKTVPAGACMGYGATYQADSEQVIA
                     TVPIGYADGWTRDMQNFSVLVDGQACPIVGRVSMDQITIRLPKPYPLGTKVTLIGSNG
                     DKEITATQVATYRVTINYEVVCLLSDRIPREYY"
     gene            complement(5032..5400)
                     /locus_tag="VXE25_000616"
     CDS             complement(5032..5400)
                     /locus_tag="VXE25_000616"
                     /EC_number="2.7.8.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000061844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="holo-ACP synthase"
                     /protein_id="HEV0771128.1"
                     /translation="MRMIVGHGIDIEELASIESAVTRHEGFAKRVLTAQEMERFTSLK
                     GRRQIEYLAGRWSAKEAFSKAMGTGISKLGFQDLEVLNNERGAPYFSQAPFSGKIWLS
                     ISHTDQFVTASVILEENHES"
     gene            complement(5439..6470)
                     /locus_tag="VXE25_000617"
     CDS             complement(5439..6470)
                     /locus_tag="VXE25_000617"
                     /EC_number="2.5.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="HEV0771129.1"
                     /translation="MAFIEKGQEIDMEVIKAETQLSAEALRLKESRDRELADIISGED
                     DRILLVIGPCSSDNEEAVLEYARRLSALQKKVADKIFMVMRVYTAKPRTNGDGYKGLV
                     HQPDTSKAPSLINGLQAVRQLHYRVITETGLTTADEMLYPSNLILVDDLVSYHAVGAR
                     SVEDQEHRFVASGIDAPVGMKNPTSGNLGVMFNAIYAAQNKQTFLYHGQEVETSGNPL
                     AHVILRGAVNEYGNYMPNYYYENLLQAIERYETMGLENPFILIDTNHDNSGKQYMEQI
                     RIVRQTLQNRDWNEKIKKTVRGFMIESYLADGRQNQPEIFGCSITDPCLGWENTEALV
                     EEIYVTLTK"
     gene            complement(6472..7503)
                     /locus_tag="VXE25_000618"
     CDS             complement(6472..7503)
                     /locus_tag="VXE25_000618"
                     /EC_number="2.5.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000232189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="HEV0771130.1"
                     /translation="MVFTAKSSKINIEEVRALSKLEGQALERKSQRDQELEAIIRGED
                     QRILLVIGPCSSDNEEAVLEYAKRLAVLQEEVADRIFMVMRVYTAKPRTNGDGYKGLI
                     HQPNATEAPSLINGIKAVRHLHYRVITETGMTTADEMLYPENLPLVDDLISYMAVGAR
                     SVEDQQHRFVASGAGFSTGFKNPTSGNLNVMFNGIYAAQNKQSFLFLGKEVETTGNPL
                     SHAILRGALNEYGKNIPNYYYDNLIDTIAQYEKMGLENPFIIIDTNHDNSGKQYIEQI
                     RIVRQTLINRAWNEKIKQFVRGFMIESYLEDGRQNEPEVFGKSITDPCLGWDNTEALV
                     REIYKTLGE"
     gene            complement(7584..10097)
                     /gene="secA"
                     /locus_tag="VXE25_000619"
     CDS             complement(7584..10097)
                     /gene="secA"
                     /locus_tag="VXE25_000619"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398886.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecA"
                     /protein_id="HEV0771131.1"
                     /translation="MANILKTIIENDKGEIRRLEKMADKVFKYEDQMAALTDDQLKAK
                     TVEFKERYQNGESLDSLLYEAFAVVREGAKRVLGLFPYKVQVMGGIVLHHGDVPEMRT
                     GEGKTLTATMPVYLNALSGKGVHVVTVNEYLSERDATEMGELYSWLGLSVGINLATKS
                     PMEKKEAYECDITYSTNSEIGFDYLRDNMVVRAENMVQRPLNYALVDEVDSILIDEAR
                     TPLIVSGANAVETSQLYHMADHYVKSLNKDDYIIDVQSKTIGLSDSGIDRAESYFKLE
                     NLYDIENVALTHFIDNALRANYIMLLDIDYVVSEEQEILIVDQFTGRTMEGRRYSDGL
                     HQAIEAKEGVPIQDETKTSASITYQNLFRMYKKLSGMTGTGKTEEEEFREIYNIRVIP
                     IPTNRPVQRIDHSDLLYASIESKFKAVVEDVKARYQKGQPVLVGTVAVETSDYISKKL
                     VAAGVPHEVLNAKNHYREAQIIMNAGQRGAVTIATNMAGRGTDIKLGEGVRELGGLCV
                     IGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDDLMKRFGSERLKGIFERLNMSE
                     EAIESRMLTRQVEAAQKRVEGNNYDTRKQVLQYDDVMREQREIIYAQRYDIITADRDL
                     APEIQSMIKRTIERVVDGHARAKQDEKLEAILNFAKYNLLPEDSITMEDLSGLSDKAI
                     KEELFQRALKVYDSQVSKLRDEEAVKEFQKVLILRVVDNKWTDHIDALDQLRNAVGLR
                     GYAQNNPVVEYQAEGFRMFNDMIGSIEFDVTRLMMKAQIHEQERPQAERHISTTATRN
                     IAAHQASMPEDLDLSQIGRNELCPCGSGKKFKNCHGKRQ"
     gene            complement(10243..10530)
                     /locus_tag="VXE25_000620"
     CDS             complement(10243..10530)
                     /locus_tag="VXE25_000620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000940707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771132.1"
                     /translation="MAHLKSFITRYSKVYIGLVLLIWLSFFFIPWDRAILGVRIDIFI
                     IQKVLLVFGILSILMALLSKKVSLFVFGLICCLSLWINLFITFAILPIFGN"
     gene            complement(10558..11190)
                     /locus_tag="VXE25_000621"
     CDS             complement(10558..11190)
                     /locus_tag="VXE25_000621"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001235275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEV0771133.1"
                     /translation="MRLEIINGQKIYGKRPILNQLNLVFQSGKIYGLKGDNGSGKTVL
                     LKILAGYIKFDKGKVLQDGKVYGIKNHYIQDAGILIEKVEFLSHLSLRENLELLRYFS
                     SKVTEKRIAYWIQYYDLQEFEDVEYRHLSLGTKQKMALIQAFISSPSILFLDEPMNAL
                     DEKSVRLTKQVILSYLKKENGLVILTSHISEDISDLCTDVLVVENGHIQM"
     gene            complement(11194..11835)
                     /locus_tag="VXE25_000622"
     CDS             complement(11194..11835)
                     /locus_tag="VXE25_000622"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000475782.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771134.1"
                     /translation="MFKNFNNIWLKRKIVLLLRIVLMMILINHLLSTAVQKQDAVIFF
                     KRELISIFSYNDYSEANLEIPKLLLNLSLFMVGWLSVILLESDLADHYHHLIRYQSSS
                     FFDYTRKRLVVISKFFTQDLFVWFLGLLPLGIHFKTVALFFLLAQLMILYLLLSYLIA
                     LISAGAGFSFFLYFLAFVGQEWMMDHIVTVYLLLLSLLVMLIVSRLEEKFKKV"
     gene            complement(11828..12619)
                     /locus_tag="VXE25_000623"
     CDS             complement(11828..12619)
                     /locus_tag="VXE25_000623"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398883.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771135.1"
                     /translation="MKIPLLTLARHKFVYVLLTLLFLALVYRDVLMTYFFFDIHAPDL
                     AKFDGQAIKNDLLKSALDFRILQFNLGFYQSFIIPIIIVLLGFQYIELKNKVLRLSIG
                     REVSYQGLKRKLTLQVASIPCLIYLVTVLIIAIVTYFFGTFSPLGWNSLFSDGSGLQR
                     LLDGEIKSYLFFTCVLLIGIFINAIYFLQIVDYVGNVTRSAITYLMFLWLGSMLLYSA
                     LPYYMVPMTSLMQASYGDVSLMKLFTPYILYVVPYMVLEKYEDNV"
     gene            complement(12804..13139)
                     /locus_tag="VXE25_000624"
     CDS             complement(12804..13139)
                     /locus_tag="VXE25_000624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771136.1"
                     /translation="MEHLFKMIILLPCFYFFSWIDKDNRESKFFPIFYYFYWIYIPLY
                     ALFSLSWTVFSVLFFNIVLRNLTDIKLWGIWLLLLLIAFASDWLDYICFKKMLDLRRE
                     LGKSKGGRH"
     gene            complement(13279..13614)
                     /locus_tag="VXE25_000625"
     CDS             complement(13279..13614)
                     /locus_tag="VXE25_000625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771137.1"
                     /translation="MEHLFKFLLLAPYFYFDNWIEKANRNSKFFPIFYYFYWIYIPFY
                     SLFSLAWTVVSVLFFNTVLRNVTDIKLWGIWFLFILLAIGMNWLTYSCFKEMFRLRQE
                     LGKSKGGRH"
     gene            complement(13705..15015)
                     /gene="der"
                     /locus_tag="VXE25_000626"
     CDS             complement(13705..15015)
                     /gene="der"
                     /locus_tag="VXE25_000626"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018377046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase Der"
                     /protein_id="HEV0771138.1"
                     /translation="MALPTIAIVGRPNVGKSTLFNRIAGERISIVEDVEGVTRDRIYA
                     TGEWLNRSFSMIDTGGIDDVDAPFMEQIKHQAEIAMEEADVIVFVVSGKEGITDADEY
                     VARKLYKTHKPVILAVNKVDNPEMRNDIYDFYALGLGEPLPISSVHGIGTGDVLDAIV
                     ENLPNEYEEENPDVIKFSLIGRPNVGKSSLINAILGEDRVIASSVAGTTRDAIDTHFT
                     DTDGQEFTMIDTAGMRKSGKVYENTEKYSVMRAMRAIDRSDVVLMVINAEEGIREYDK
                     RIAGFAHEAGKGMIIVVNKWDTLEKDNHTMKNWEEDIREQFQYLPYAPIIFVSALTKQ
                     RLHKLPGMIKQISESQNTRIPSAVLNDVIMDAIAINPTPTDKGKRLKIFYATQVATKP
                     PTFVIFVNEEELMHFSYLRFLENQIRKAFVFEGTPIHLIARKRK"
     gene            complement(15029..15742)
                     /locus_tag="VXE25_000627"
     CDS             complement(15029..15742)
                     /locus_tag="VXE25_000627"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000140867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADPH-dependent oxidoreductase"
                     /protein_id="HEV0771139.1"
                     /translation="MTETIKLMKAHTSVRRFKEQEIPQVDLNEILTAAQMASSWKNFQ
                     SYSVIVVRSQEKKDALYELVPQEAIRQSAVFLLFVGDLNRAEKGARLHTDTFQPQGVE
                     GLLISSVDAALAGQNALLAAESLGYGGVIIGLVRYKSEEVAELFNLPDYTYSVFGMAL
                     GVPNQHHDMKPRLPLENVVFEEEYQEQSTEAIQAYDRVQADYAGARATTSWSQRLAEQ
                     FGQAEPSSTRKNLKQKKLL"
     gene            complement(15739..16635)
                     /gene="dnaI"
                     /locus_tag="VXE25_000628"
     CDS             complement(15739..16635)
                     /gene="dnaI"
                     /locus_tag="VXE25_000628"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primosomal protein DnaI"
                     /protein_id="HEV0771140.1"
                     /translation="MESVGDVLKRQPSRFHYQDLVQKIMKDPDVAAFVQQESLNQDEL
                     NRSISKFNQYITERDKFLRGDTDYIAKGYKPILVMNHGYADVSYEETPELIAAEKEAA
                     IKKRLNLINFPSSLKNVSFLDVYRDDVQRLTVLKRMIEFVNDYPNNLKGLYLYGDFGV
                     GKSFMVAALAHDLSEKRGVSSTLLHYPSFVIDVKNAIGDGNVKTLVDEIKLSEVLILD
                     DIGAEQSTAWVRDEILQVILQYRMQENLPTFFTSNFNFEDLEKHFAKGKNGNDETWEA
                     RRVMERIRYLAEETRLEGVNRR"
     gene            complement(16636..17805)
                     /locus_tag="VXE25_000629"
     CDS             complement(16636..17805)
                     /locus_tag="VXE25_000629"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000802368.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation and membrane attachment
                     family protein"
                     /protein_id="HEV0771141.1"
                     /translation="MKPIDRFSYLKNNRVSQDTSSLVQCYLPIIGQEALSLYLYTISF
                     WDNGRKEYLFSSILNHLNFGMDRLIKSLKILSAFNLLTLYQKGDVYQLALHAPLSSQD
                     FLEHPVYRRLLEKKIGDSAVEDLKVESADGEEIPVSLNQVFPELAELGSQEDLGLKKK
                     VANDFDLEHFRQLMARDGLRFADEQSDVLNLFAIAEEKKWTWFETYQLAKSTAVSQVI
                     STKRMREKIAQKPVSSDFSLKETTIIKEAKSKTALQFLAEIKQTRKGTITQTERELLQ
                     QMAGLGLLDEVINIILLLTFNKVDSANINEKYAMKVANDYAYQKIHSAEKAVLRIRER
                     GQKTKTQKQNQTAPAKTNIPKWSNPEYKNTSSAEELEEMERQTLELLAKLDNGGD"
     gene            complement(17806..18279)
                     /gene="nrdR"
                     /locus_tag="VXE25_000630"
     CDS             complement(17806..18279)
                     /gene="nrdR"
                     /locus_tag="VXE25_000630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001203675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor NrdR"
                     /protein_id="HEV0771142.1"
                     /translation="MRCPKCGATKSSVIDSRQAEEGNTIRRRRECDECQHRFTTYERV
                     EERTLVVVKKDGTREQFSRDKIFNGIIRSAQKRPVSSDEINMVVNRIEQKLRGRNENE
                     IQSEDIGSLVMEELAELDEITYVRFASVYRSFKDVSELESLLQQITQSSKKKKER"
     gene            18419..18784
                     /locus_tag="VXE25_000631"
     CDS             18419..18784
                     /locus_tag="VXE25_000631"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HEV0771143.1"
                     /translation="MSWTFDNKKPIYLQIMEKIKLQIVSHTLEPNQQLPTVRELASEA
                     GVNPNTIQRALSDLEREGFVYSKRTTGRFVTKDKELIAQSRKQLSEEELEHFVSSMTH
                     FGYEKEELPGVVSDYIKGV"
     gene            18789..19484
                     /locus_tag="VXE25_000632"
     CDS             18789..19484
                     /locus_tag="VXE25_000632"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0771144.1"
                     /translation="MSLLAFENVSKSYGATPALENVSLDIPAGKIVGLLGPNGSGKTT
                     LIKLINGLLQPDQGRVLINDMDPSPATKAVVAYLPDTTYLNEQMKVKEALTYFKTFYK
                     DFNLERAHHLLADLGIDENSRLKKLSKGNKEKVQLILVMSRDARLYVLDEPIGGVDPA
                     ARAYILNTIINNYSPTSTVLISTHLISDIEPILDEIVFLKDGKVVRQGNVDDIRYESG
                     ESIDQLFRQEFKA"
     gene            19501..20268
                     /locus_tag="VXE25_000633"
     CDS             19501..20268
                     /locus_tag="VXE25_000633"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000498762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771145.1"
                     /translation="MFWNLVHYEFKNVNKWYLALYAAVLVLSALIGIQTQGFKNLPYQ
                     ESQATMLLFLATVFGGLMLTLAISTIFLIIKRFKGSVYDRQGYLTLTLPVSEHHIITA
                     KLIGAFIWSLISTAVLALSAVIILALTAPEWIPLSYVITFVETHLPQIFLTGISFLLN
                     TISGILCIYLAISIGQLFNEYRTALAVAAYIGIQIVIGFIELFFNLSSNFYVNSLVGL
                     NDHFYMGAGIAIVKELIFIAIFYLGTYYILRNKVNLL"
     gene            complement(20621..21820)
                     /locus_tag="VXE25_000634"
     CDS             complement(20621..21820)
                     /locus_tag="VXE25_000634"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001245382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEV0771146.1"
                     /translation="MRNMWVVIKETYLRHVESWSFFFMVISPFLFLGISVGIGHLQGS
                     SMAKNNKVAVVTTVPSVAEGLKNVNGVNFDYKDEASAKEAIKEEKLKGYLTIDQEDSV
                     LKAVYHGETSLENGIKFEVTGTLNELQNQLNRSTASLSQEQEKRLAQTIQFTEKIDEA
                     KENKKFIQTIAAGALGFFLYMILITYAGVTAQEVASEKGTKIMEVVFSSIRASHYFYA
                     RMMALFLVILTHIGIYVVGGLAAVLLFKDLPFLAQSGILDHLGDAISLNTLLFILISL
                     FMYVVLAAFLGSMVSRPEDSGKALSPLMILIMGGFFGVTALGAAGDNLLLKIGSYIPF
                     ISTFFMPFRTINGYAEGAEAWISLAITVIFAVVATGFIGRMYASLVLQTDDLGIWKTF
                     KRALSYK"
     gene            complement(21817..22710)
                     /locus_tag="VXE25_000635"
     CDS             complement(21817..22710)
                     /locus_tag="VXE25_000635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895295.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0771147.1"
                     /translation="MLEVRSLEKSFGSKQVLFGIDFQARPGRILGLVGKNGAGKTTIF
                     HSILKFLEYQGEIGLDGQDIRQETYARIGYLPEERSLMPKLTVLEQVRYLATLKGMDA
                     KEVKEKLPQWMKRLEVKGKLTDKIKSLSKGNQQKIQLIITLIHEPDLIILDEPFSGLD
                     PVNTELLKQVIFQEKERGATIIFSDHVMTNVEELCDDILMIRDGRVVLHGPVQDVRNQ
                     YGKTRLFVSSERSKEELENLPHVKQVSLTKQGSWKLILEDESAGRELFPILTQGQYIA
                     TFDQQAPTIDEIFKLESGVEV"
     gene            22826..22906
                     /locus_tag="VXE25_000636"
                     /pseudo
     CDS             22826..22906
                     /locus_tag="VXE25_000636"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            23391..23604
                     /locus_tag="VXE25_000637"
                     /pseudo
     CDS             23391..23604
                     /locus_tag="VXE25_000637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001153868.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
     gene            24019..24636
                     /locus_tag="VXE25_000638"
     CDS             24019..24636
                     /locus_tag="VXE25_000638"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000076166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TVP38/TMEM64 family protein"
                     /protein_id="HEV0771148.1"
                     /translation="MSQDKQMKAVSPLLQRVINISSIVGGVGSLIFCIWAYQAGILQS
                     KETLSAFIQQAGIWGPPLFIFLQILQTVVPIIPGALTSVAGVFIYGHIIGTIYNYIGI
                     VIGCAIIFYLVRLYGAAFVQSVVSKRTYDKYIGWLDKGNRFDRFFIFMMIWPISPADF
                     LCMLAALTKMSFKRYMTIIILTKPFTLVVYTYGLTYIIDFFWQML"
     gene            complement(24679..25566)
                     /locus_tag="VXE25_000639"
     CDS             complement(24679..25566)
                     /locus_tag="VXE25_000639"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000164317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HEV0771149.1"
                     /translation="MTKLYGSLEAGGTKFVCAVGDENFNVVEKTQFPTTTPIETIDKT
                     IEFFSKFDNLAGLAVGSFGPIDIDKNSKTYGFITTTPKPNWANVDLLGALRRALNVPM
                     YFTTDVNSSAYGEMVARNNAGGRIENLVYYTIGTGIGAGVIQRGEFIGGVGHPEMGHY
                     YVARHPMDIEKEFKGVCPFHKGCLEGYAAGPSLEARTGVRGETIELNNPVWDVQAYYI
                     AQAAVNATVTFRPDVIVFGGGVMAQQHMLDRVREKFTSLLNGYLPVPDVRDYIVTPAV
                     AGNGSATLGNFVLAKEVSK"
     gene            complement(25715..27598)
                     /locus_tag="VXE25_000640"
     CDS             complement(25715..27598)
                     /locus_tag="VXE25_000640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864794.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HEV0771150.1"
                     /translation="MNNQEIAKKVIDALGGRENVNSVAHCATRLRVMVKDEEKINKEV
                     IENLEKVQGAFFNSGQYQIIFGTGTVNKMYDEVVVLGLPTSSKDDMKAEVAKQGNWFQ
                     RAIRTFGDVFVPIIPVIVATGLFMGVRGLFNALEMPLPGDFATYTQILTDTAFIILPG
                     LVVWSTFRVFGGNPAVGIVLGMMLVSGSLPNAWAVAQGGEVTAMNFFGFIPVVGLQGS
                     VLPAFIIGVVGAKFEKAVRKVVPDVIDLLVTPFVTLLVMSILGLFVIGPVFHVVENYI
                     LIATKAILSMPFGLGGFLIGGVHQLIVVSGVHHIFNLLEVQLLAADHANPFNAIITAA
                     MTAQGAATVAVGVKTKNPKLKTLAFPAALSAFLGITEPAIFGVNLRFRKPFFLSLIAG
                     AIGGGLASILGLAGTGNGITIIPGTMLYVGNGQLPQYLLMVAVSFALGFALTYMFGYE
                     DEVDATAAAKQAEVAEEKEEVAPAALQNETLVTPIVGDVVALADVNDPVFSSGAMGQG
                     IAVKPSQGVVYALADAEVSIAFPTGHAFGLKTRNGAEVLIHVGIDTVSMNGDGFEAKV
                     AQGNKVKAGDVLGTFDSNKIAAAGLDDTTMVIVTNTADYASVAPVATGSVSKGDAVIE
                     VKI"
     gene            27975..29429
                     /locus_tag="VXE25_000641"
     CDS             27975..29429
                     /locus_tag="VXE25_000641"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455313.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 32 protein"
                     /protein_id="HEV0771151.1"
                     /translation="MEWTTERRYRLYQDWTQEEIQHIKENMAQSPWHTHYHVEPKTGL
                     LNDPNGFSYFDGKWILFYQNFPFGAAHGLKSWAQLESDDLVHFRETGVKVLPDTPLDS
                     HGAYSGSAMQFGDNLFLFYTGNVRDENWIRHPYQIGALMDKEGKITKIDKILIDQPAD
                     STDHFRDPQIFNFQGQYYAIVGGQDLEKKGFVRLYKAVNNDYTNWQAVGNLDFANDRT
                     AYMMECPNLVFVEEQPVLLYCPQGLDKKVLDYDNIFPNMYKIGASFDPKNAKMVDVSQ
                     LQNMDYGFEAYATQAFNAPDGRALAVSWLGLPDVSYPSDRFDHQGTFSLVKELTIKDD
                     KLYQYPVAAIKDLRASEEAFSNRSQTKNTYELELNLEANSQSEIVLLADKEGKGLSIN
                     FDLVNGQVTVDRSHAGEQYAQEFGTTRSCPIENQATTATIFIDNSVFEIFINKGEKVF
                     SGRVFPHADQNGILIKSGNPTGTYYELDYGRKTN"
     gene            29410..30375
                     /locus_tag="VXE25_000642"
     CDS             29410..30375
                     /locus_tag="VXE25_000642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002929307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEV0771152.1"
                     /translation="MVAKLTDVAKLAGVSPTTVSRVINKKGYLSEKTIQKVNEAMREL
                     GYKPNNLARSLQGKSAKLIGLIFPNISNVFYAELIDKLEHQLFKNGYKTIICNSEHDS
                     EKEREYIEMLEANQVDGIISGSHNLGIEDYNRVTAPIISFDRNLSPDIPVVSSDNYAG
                     GVLAAQTLVKTGAQSIIMITGNDNSNSPTGLRHAGFASVLPKAPIINVSSDFSPVRKE
                     MEIKNILTREKPDAIFASDDLTAILVIKIAQELGISVPKELKVIGYDGTYFIENYYPQ
                     LATIKQPLEEIACLTIDLLLQKIEGKEVATTGYFLPVTLLPGKSI"
     gene            complement(30410..31684)
                     /locus_tag="VXE25_000643"
     CDS             complement(30410..31684)
                     /locus_tag="VXE25_000643"
                     /EC_number="1.1.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000704367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxymethylglutaryl-CoA reductase,
                     degradative"
                     /protein_id="HEV0771153.1"
                     /translation="MKISWNGFSKKSYQERLELLKAQALLSPERQASLEKDEQMSVTV
                     ADQLSENVVGTFSLPYSLVPEVLVNGQEYTVPYVTEEPSVVAAASYASKIIKRAGGFT
                     AQVHQRQMIGQVALYQVANPKLAQEKIASKKAELLELANQAYPSIVKRGGGARDLHVE
                     QIKGEPDFLVVYIHVDTQEAMGANMLNTMLEALKPVLEELSQGQSLMAILSNYATDSL
                     VTASCRIAFRYLSRQKDQGREIAEKIALASQFAQADPYRAATHNKGIFNGIDAILIAT
                     GNDWRAIEAGAHAFASRDGRYQGLSCWTLDLEREELVGEMTLPMPVATKGGSIGLNPR
                     VVLSHDLLGNPSARELAQIIVSIGLAQNFAALKALVSTGIQQGHMKLQAKSLALLAGA
                     SESEVAPLVEQLIADKTFNLETAQRYLENLRS"
     gene            complement(31684..32856)
                     /locus_tag="VXE25_000644"
     CDS             complement(31684..32856)
                     /locus_tag="VXE25_000644"
                     /EC_number="2.3.3.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004181031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxymethylglutaryl-CoA synthase"
                     /protein_id="HEV0771154.1"
                     /translation="MTIGIDKIGFATSQYVLKLQDLAEARGIDPEKLSKGLLLKELSI
                     APLTEDIVTLAASASDSILTEQERQEVDMVIVATESGIDQSKAAAVFVHGLLGIQPFA
                     RSFEIKEACYGATAALHYAKLHVENSPESKVLVIASDIAKYGIETPGEPTQGAGSVAM
                     LITQNPRMMAFNNDNVAQTRDIMDFWRPNYSTTPYVNGVYSTQQYLDSLKTTWLEYQK
                     RYQLTLDDFAAVCFHLPYPKLALKGLKKIMDKSLPQEKKDLLQKHFDQSILYSQKVGN
                     IYTGSLFLGLLSLLENTDSLKAGDKIALYSYGSGAVAEFFSGELVEGYEAYLDKDRLN
                     KLNQRTALSVADYEKVFFEEVNLDETNSAQFAGYENQDFALVEILDHQRRYSKVEK"
     gene            complement(32987..33235)
                     /locus_tag="VXE25_000645"
     CDS             complement(32987..33235)
                     /locus_tag="VXE25_000645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001858369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771155.1"
                     /translation="MVSSSGSEFQSGWQEHQLIAEKVSKTLDKTFDKDVREIPTSQFY
                     QKFVDEMGRTYSGNLILQELITVNGAYKATYIGELSSN"
     gene            complement(33303..33907)
                     /locus_tag="VXE25_000646"
                     /pseudo
     CDS             complement(33303..33907)
                     /locus_tag="VXE25_000646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(33969..34418)
                     /locus_tag="VXE25_000647"
     CDS             complement(33969..34418)
                     /locus_tag="VXE25_000647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HEV0771156.1"
                     /translation="MTLTTFLLQAVASFLAIITFLIVLNVQRSMLLPGGILGMTVWLI
                     YLLLKEPTNVIVATFIAAIIGSCVSQILSILYKTPAVVFILAILAPLVPGYLSYRTTA
                     FFVTGDYNKALASATLVVMLALVISIGMASGTVILRLYNYIKTHRVS"
     gene            complement(34420..35178)
                     /locus_tag="VXE25_000648"
     CDS             complement(34420..35178)
                     /locus_tag="VXE25_000648"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000392945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HEV0771157.1"
                     /translation="MEESKELNAVIDVIMLAGTILLKSGSEIHRVEDTMIRIAHSQGI
                     VDCNVLAMPAAIFFSIENTNISRMKRVTSSSYNIEKVCDVNQISRQLVGGQIDLETAF
                     KQLTALQAQPLPYTKLQVTLAATFSAPFFSVMFSGNIYDALGAGVATLFGFAFSLYVE
                     KFIRIPFVTAFAGAFVFGIIAQFWARYTGFPSTADLIIAGAVMPFVPGIALTNAVRDI
                     MTNHINSGMSKMFESLLITLALGAGTSVALVLMN"
     gene            complement(35293..37272)
                     /gene="pknB"
                     /locus_tag="VXE25_000649"
     CDS             complement(35293..37272)
                     /gene="pknB"
                     /locus_tag="VXE25_000649"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="HEV0771158.1"
                     /translation="MIQIGKIFAGRYRIVKQIGRGGMADVYLAKDLILDGEEVAVKVL
                     RTNYQTDPIAVARFQREARAMADLDHPHIVRITDIGEEDGQQYLAMEYVAGLDLKRYI
                     KEHYPLSNEEAVRIMGQILLAMRLAHTRGIVHRDLKPQNILLTPDGTAKVTDFGIAVA
                     FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIIFYEMLTGHIPYDGDSAV
                     TIALQHFQKPLPSVIAENPSVPQALENVIIKATAKKLTNRYRSVSEMYVDLSSSLSYN
                     RRNESKLIFDETSKADTKTLPKVSQSTLTSIPKVQAQTEHKSIKNPSQAVTEETYQPQ
                     APKKHRFKMRYLILLASLVLVAASLIWILSRTPATIAIPDVAGQTVAEAKATLKKANF
                     EIGEEKTEASEKVEEGRIIRTDPGAGTGRKEGTKINLVVSSGKQSFQISNYVGRKSSD
                     VIAELKEKKVPDNLIKIEEEESNESEAGTVLKQSLPEGTTYDLSKATQIILTVAKKAT
                     TIQLGNYIGRNSTEVISELKQKKVPENLIKIEEEESSESEPGTIMKQSPGAGTTYDVS
                     KPTQIVLTVAKKVTSVAMPSYIGSSLEFTKNNLIQIVGIKEANIEVVEVTTAPAGSAE
                     GMVVEQSPRAGEKVDLNKTRVKISIYKPKTTSATP"
     gene            complement(37269..38009)
                     /locus_tag="VXE25_000650"
     CDS             complement(37269..38009)
                     /locus_tag="VXE25_000650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Stp1/IreP family PP2C-type Ser/Thr phosphatase"
                     /protein_id="HEV0771159.1"
                     /translation="MEISLLTDVGQKRTNNQDYVNHYVNRAGRTMIILADGMGGHRAG
                     NIASEMAVTDLGVAWVDTQIDTVNEVREWFAHYLEIENQKIHQLGQDEAYRGMGTTLE
                     VLAIIDNQAIYAHIGDSRIGLIRGEEYHQLTSDHSLVNELLKAGQLTPEEAEAHPQKN
                     IITQSIGQKDEIQPDFGTVILESGDYLLLNSDGLTNMISGSEIRDIVTSDIPLADKTE
                     TLVRFANNAGGLDNITVALVSMNEEDAE"
     gene            complement(38024..39337)
                     /gene="rsmB"
                     /locus_tag="VXE25_000651"
     CDS             complement(38024..39337)
                     /gene="rsmB"
                     /locus_tag="VXE25_000651"
                     /EC_number="2.1.1.176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (cytosine(967)-C(5))-methyltransferase
                     RsmB"
                     /protein_id="HEV0771160.1"
                     /translation="MTKVETARSLALAVLEDVFVNQAYSNIALNKHLKGSQLSAADKG
                     LVTELVYGTVARKLTLEWYLSHFIEDRDQLDSWLYVLLLMSAYQLRYLDKIPDHAVVN
                     EAVELAKLRKKGSEKLVNAVLRRILREGWPDIASIKRKNKRDSIAYSLPVWLVAKLKE
                     EYGEERAKAIFESLLVRNKASIRVTDLSRKEEIQALLEANNSLLATTGLVKEQGHFAG
                     HNLFANGAITIQDESSQLVAPTLDLQGDERVLDACAAPGGKTAHIASYLTTGQVTALD
                     LYDHKLDLIQENAQRLGVEDRVQTQKLDARKVHEFFDQDSFDKILVDAPCSGIGLLRR
                     KPDIKYNKETADFASLQEIQLEILGSVCQILGKGGIITYSTCTIVSEENFQVVKAFLE
                     SHPEFEQVKLEHECKDIMKDGCILITPELYGSDGFFISQFRKISD"
     gene            complement(39330..40265)
                     /locus_tag="VXE25_000652"
     CDS             complement(39330..40265)
                     /locus_tag="VXE25_000652"
                     /EC_number="2.1.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionyl-tRNA formyltransferase"
                     /protein_id="HEV0771161.1"
                     /translation="MTKLIFMGTPDFSATVLKGLLTDDRYEILAVVTQPDRAVGRKKV
                     IQETPVKQAAKEAGLSIYQPEKLSGSPEMEELMKLGADGIVTAAFGQFLPSKLLDSMD
                     FAVNVHASLLPRHRGGAPIHYALIQGDEEAGVTIMEMVKEMDAGDMISRRSIPITDED
                     NVGTLFEKLALVGRDLLLDTLPAYIAGDIKPEPQDTSQVTFSPNIKPEEEKLDWNKTN
                     RQLFNQIRGMNPWPVAHTFLKGDRFKIYEALPVEGQGNPGEILSICKKELIVATAEGA
                     LSLKQVQPAGKPKMDIASFLNGVGRTLTVGERFGD"
     gene            complement(40278..42674)
                     /locus_tag="VXE25_000653"
     CDS             complement(40278..42674)
                     /locus_tag="VXE25_000653"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001162119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primosomal protein N'"
                     /protein_id="HEV0771162.1"
                     /translation="MALAKIIVDVPLMQTDQPYSYRIPEEFEGMLEVGMRVHVPFGKG
                     NRLIQGIVLGLESQSDGEEMEQDLKDIAEVLDFSPVLTPEQLWLAEELRKSVFSYKIS
                     ILKAMLPGFLNSSYDKILYPLEGLSQEERVRLFGSEDSLAFSSLDLGKQAEMMRLTRK
                     GLLGLEYQAVDQKKVKTQSWYEVDHAQLEGVEISTRAKKKLELRDYLLSHPESASLAS
                     LLESYSREQVNFFVDQGAVTIVQKEVQRSAAYFEGIEASRPLELNPEQRQARDAVVSS
                     IGSSQPPFLLQGITGSGKTEVYLQIIQGALDKGKTAILLVPEISLTPQMTERFIARFG
                     DKVAILHSGLSNGEKYDEWRKVERGDAQVVVGARSAIFAPLKNLGVMIIDEEHEAAYK
                     QESNPRYHAREVAILRAQYNQATLVLGSATPSLESRARAGKGVYQHLRLTQRANPLAT
                     IPEVQVIDFRDYIGQNETSNFTPPLLEAIQDRLVKKEQVVLMLNRRGYSSFVMCRECG
                     TVDTCPNCDISLTLHMDTKTMNCHYCGFSKDIPQVCPNCKSHSIRYYGTGTQKVYDEL
                     AELFPQARILRMDVDTTRKKGSHQALLDQFGRGEADILLGTQMIAKGLDFPNVTLVGV
                     LNADTALNLPDFRSSERTFQLLTQVAGRAGRAEKAGQVLIQSYNPQHYAIRFAKDQDY
                     EGFYAYEMGIRRQLGYPPYYFTIGITLSHKKEEEVFKRAYEVMNILRSGLSETSPILG
                     PTPKPIARTHNLYHYQILIKYRLEDELGPTLNQVLALTQERENSELRLSIDHEPQQFL
                     "
     gene            complement(42740..43054)
                     /locus_tag="VXE25_000654"
     CDS             complement(42740..43054)
                     /locus_tag="VXE25_000654"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001817694.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit omega"
                     /protein_id="HEV0771163.1"
                     /translation="MMLKPSIDTLLDKVPSKYSLVILEAKRAHELEAGAPATQGFKSE
                     KSTLRALEEIESGNVTIHPDPEGKREAVRRRIEEEKRRKEEEEKKIKEQIAKEKEDGE
                     KI"
     gene            complement(43079..43705)
                     /gene="gmk"
                     /locus_tag="VXE25_000655"
     CDS             complement(43079..43705)
                     /gene="gmk"
                     /locus_tag="VXE25_000655"
                     /EC_number="2.7.4.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000775037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="guanylate kinase"
                     /protein_id="HEV0771164.1"
                     /translation="MADRGLLIVFSGPSGVGKGTVRREIFESSENQFQYSVSMTTRAQ
                     RPGEVDGVDYFFRTREEFEELIRQGQMLEYAEYVGNYYGTPLTYVNETLDKGIDVFLE
                     IEVQGALQVKKKVPDAVFIFLTPPDLDELQDRLVGRGTDSAEVIAQRIEKAKEEIALM
                     REYDYAIVNDQVPLAAERVKCVIEAEHFCVDRVIGHYQEMLPKSPTTR"
     gene            complement(43835..45448)
                     /locus_tag="VXE25_000656"
     CDS             complement(43835..45448)
                     /locus_tag="VXE25_000656"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520539.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease Y"
                     /protein_id="HEV0771165.1"
                     /translation="MEIMSLAIAVFAVIIGLVIGYVSISAKMKSSHEAAELMLLNAEQ
                     EATNLRGQAEREADLLVNEAKRESKSLKKEALLEAKEEARKYREEVDAEFKSERQELK
                     QIESRLTERATSLDRKDDNLTSKEQTLEQKEQSISDRAKNLDAREEQLEEVERQKEAE
                     LERIGALSQAEARDIILAQTEENLTREIASRIREAEQEVKERSDKMAKDILVQAMQRI
                     AGEYVAESTNSTVHLPDDTMKGRIIGREGRNIRTFESLTGVDVIIDDTPEVVTLSGFD
                     PIRREIARMTMEMLLKDGRIHPARIEELVEKNRQEIDNKIREYGEAAAYEIGAPNLHP
                     DLMKIMGRLQFRTSYGQNVLRHSIEVAKLAGIMASELGENAALARRAGFLHDIGKAID
                     HEVEGSHVEIGMELARKYKEPPVVVNTIASHHGDVEAESVIAVIVAAADALSAARPGA
                     RSESLESYIKRLHDLEEIANGFEGVQTSFALQAGREIRIMVNPGKIKDDKVTILAHKV
                     RKKIENNLDYPGNIKVTVIRELRAVDYAK"
     gene            complement(45639..45893)
                     /locus_tag="VXE25_000657"
     CDS             complement(45639..45893)
                     /locus_tag="VXE25_000657"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006152757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Txe/YoeB family addiction module toxin"
                     /protein_id="HEV0771166.1"
                     /translation="MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGK
                     PEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSFKDHY"
     gene            complement(45897..46151)
                     /locus_tag="VXE25_000658"
     CDS             complement(45897..46151)
                     /locus_tag="VXE25_000658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000388574.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system Phd/YefM family
                     antitoxin"
                     /protein_id="HEV0771167.1"
                     /translation="MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKS
                     EWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVHVIEE"
     gene            complement(46389..47486)
                     /locus_tag="VXE25_000659"
     CDS             complement(46389..47486)
                     /locus_tag="VXE25_000659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000156376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase"
                     /protein_id="HEV0771168.1"
                     /translation="MTITGIIAEFNPFHNGHKYLLDQAEGLKIVAMSGNFMQRGEPAI
                     VDKWTRAQMALENGADLVVELPFLVSVQAADFFGQGAVDILARLGIDSLAFGTEEVLD
                     YQKIADLYTEKGAEMEKFVENLPDSLSYPQKTQAMWKEFAGLDFSGNTPNHVLALAYA
                     KAVAGRNIKLHPIQRQGAGYHSVNKDVDFASATALRQHQKDQDFLERFMPSVALFEQA
                     SKVIWEDYFPLLRYQILSNPDLTTIYQVNQEMAVRIKEAIKTAQSVEELVEAVATKRY
                     TKARVRRLLTYILVQARENVLPEAIHVLGFTEKGRQHLKSLKGQVNLVSRIGKEPWDA
                     MTQKADQIYQLGKPSIAEQNFGRVPIRIETS"
     gene            complement(47510..>49046)
                     /locus_tag="VXE25_000660"
     CDS             complement(47510..>49046)
                     /locus_tag="VXE25_000660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001025034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="NACHT domain-containing protein"
                     /protein_id="HEV0771169.1"
                     /translation="TELIFEKTSNVILTGTGGIGKSMLVKHIFINQVQQATSIPIFIE
                     LKSLNESDFSENELVDFIYQEVQNHHLNLEKKYFKATLEAGRYTIIFDGLDEVNPSKR
                     SWLDKEIKEFVTLYNSNRYVLSSRPSEEFIGWNQFAEYEIKKLNREQALSLIDKLNYD
                     EKVKRRFYRELKDHLYDTHESFASIPLLLTIMLMTYEAGASIPNNLTDFYNQAFYTLY
                     QRHDASKSGYKRELKAKLTPEEFRNILAYIGLKTFFEGKVDFDRTTLDEIITKYCFKN
                     NLELKTNDIVYDATHSACMMLQEGVSLKFSHRSFQEYFAAVGVNQLDDKLQKQILIKW
                     SEADRNNIVAHKTFMNALFKIQKERTYKNLCIPIIERMDEKYSRMGDITEKIVTCFNY
                     FICRKDSRENKLELHFLLTKEVHFYFSLQFLIFANLGIDILSISDYENIEKLESDIVS
                     NWKINERKYYNMLNDDEKTLINKWINGWYFSRHNYLKEWSIKFIEETTTQKRSLQNII
                     DSI"
BASE COUNT        14029 a        11077 c         9297 g        14643 t
ORIGIN      
        1 aaggcgaagc tgacgtggtt tgaagagatt tttgaaaagt attaacacct acagacaagc
       61 ctgacgatag caagaactac cctactcgat aggtatcggc ttttgctttc tgaaaaaaat
      121 tattttaagc aatttgacaa atctagcaac aaaaaattct ataaatacaa tagattgaaa
      181 ctagaatagt acacctttgc ttctaaaaca ttgttagaaa tcgatttgac tgtcctgatc
      241 gatttgtcct gttcttgttt catttcacta tatttccatg ataaaacgca tagtatcaag
      301 ttttcttaat cccctgatac tatgcgtgtt tgtaattttt aagattttgt gcttagagtc
      361 gactccttat tttagatatt taaaaggaat ctcacttcca cagagccagt tgtagacttg
      421 gtcattaaca aatacattca tggcttcgtg agcatactca ggcatgatac gataggtttt
      481 atcgcaggtc agacgattat aaatcgcaaa ctgggtaatg ggatagcaaa catcgtcgtc
      541 caagcccgta atcatcttaa cctcaccttg gatacgatgg gcaagatttt tgacatcgat
      601 ataggcaagg gtcgccatga tttcctcctc tgtttcatgg aaggggtcgt gaaacttgaa
      661 ataacggaaa agttcgtcgt aagcctcgct agtattacca atctcaatca cccgtctgaa
      721 gtctgacaag aagggataaa tggcaactgt tttctgaatt cgaggattga gcgctgctgc
      781 aactagagct agagcccctc cttgtgaggc accatagcta gaaagacgct tctcatcaac
      841 ctgagacaga ctagcaacaa tttcgaccaa ctggtaaata tccagataaa catccttata
      901 aaagaggtgg tcccgacctt ccatagcacc acggataata tgccccttca cggtatttcc
      961 taaaggagaa cgcaagccgt cttgtgagta acctgactgg ccccgcacat ccatggaaac
     1021 aacaccgtaa ccagctacgg tgaagcccag catgtcggcc cagtcccagc cacgtcccat
     1081 ataaccatga aaatggaaga ttaatggaac cttctcctca ctctttggaa gaacaatgcg
     1141 tgcatagacc tttccttcct tgcttccttc aaatgttaac tcatagcact tgacttgagg
     1201 aatgtggaaa tctctttcct ccaagtggta ggatggaagc gtggaaacat ttttcacttc
     1261 cccatcccag aaagcatcaa agtcttccgg aacctcatcc cttcctctat aggtcttaat
     1321 ttcttctagc aaagctgaat ttttcatagc atgctccttt tattttgtaa tcgttaccac
     1381 aactgtagca tatctatgta atcaatgcaa gaaagaaggg taaatagaaa gtgaatttag
     1441 attctttact tttaggatga tgggctgaaa gtagttttag aaacgaaaaa agagcatttc
     1501 gctctctctt ctgtttatac tagttttttg cttccttctt ttggaaagtg atttggtaat
     1561 ttactttaat cgttactgtc atatgagagt cctcgtttct ttttgatgac tttagtataa
     1621 gagccaaacc taaaaactag cttaatactc ttcgaaaatc tcttcaaacc acgtcagcgt
     1681 cgccttaccg tatatatgtt actgacttcg tcagttctat ctgccacctc aaaacagtgt
     1741 tttgagctga cttcgtcagt tctatctgcc acctcaaaac agtgttttga gctgacttcg
     1801 tcagtttcat ccacaacctc aaaacagtgt tttgagcaac ctgcggttag cttcctagtt
     1861 tgctctttga ttttcattga gtataagttt tccttagaga aagcttaatc cagatgttct
     1921 ttcttttcca gatgaagggc aatcatgcgc cactctggat cttcttgcca agcttctata
     1981 gaactaatgt agctagcaac ctttcttgct tcttctaaaa tcggaaaatc ttcgataata
     2041 tcagccactt ggaactctgg aagtcctgac tgtctggttc caaaaatctc accagaacca
     2101 cgcattttca aatcttcctc cgcaaggaca aatccattgg tcgtttctgt catgatgcgc
     2161 atgcggtctt tcccagaatc cgtcttggga ttggcaacga gaacagcgta ggactgtttg
     2221 tccccccgac cgacacgacc tctaagctgg tgaagttgac tgagaccgaa gcgatcggca
     2281 tccatgataa tcatgacagt cgcattggga acgttgaccc caacctcaat aaccgtcgtc
     2341 gaaaccagaa tatccgtctt tctctccttg aaatcctgca tgatctggtc tttttcgtca
     2401 ctcttcatcc taccatgtag aagagccacc tctgccttgc atgcaaaatg agtcgtcaac
     2461 tcctctgata aggcaatggc atttttcaaa tctagagctt ctgattcttc aatcaaagga
     2521 gagatgacat aggcttggga acctttttga atttccccct ctaaccaagt caagacctga
     2581 ggtagttgct catgtttgat ccagcgcgtc acaatagact tccgacctgc tggcatctgg
     2641 tctataatgg aaacatccat atctccaaag gctgtgatgg caagcgtccg tggaatggga
     2701 gtcgccgtca tcatgaggac atctggattg tcaccttttt cccgtaaaat acgcctttgc
     2761 cctacaccaa aacggtgctg ctcatcgata ataatcaaac caagacgagc atactccacc
     2821 ccatcttgta tcagagcgtg agttcctata atcaaatcag cctcaccctt ggcaatggtc
     2881 tgcaagactt ctctcttttc tgcagctttc aaggaacctg tcaagagagc caatttcaaa
     2941 ttgggaaaaa ggttctgtaa actctcaaag tgttgctctg cgaggatttc tgttggtacc
     3001 attagggcag cctgataacc tgctgtcact gccgcaaaca tggccaagcc agcgactacc
     3061 gtttttccac tccccacatc cccttgtagg agacgattca tgtggtggtc ggacttcata
     3121 tcagttaaaa tttcctgcaa actcttttcc tgagcttggg tcagggcaaa aggaagactt
     3181 actttaactg ctgtcacttt ttcctgagac caattcagaa ccagaccact tccctgaact
     3241 ctattttcag acttgagcgt ctgcaactgc atttggaaat aaaagagttc ctcaaacttg
     3301 atacggcgaa gagcctgctt gtattctgcc aaatcctttg gaaaatgcat agctcggact
     3361 gcctgacaac gggacatgag tttgtatttg tctagtaaag actggggcag attttcttct
     3421 atcaagaggt ccagtccctg atcaaaagcc gtcttgatga ccttaaccag actggcctga
     3481 ctgattccct gagccagacg atagacaggc tggaggtcat cttctacctg agccagaacc
     3541 ttcatcccag tcagactagc cttagcgcgg tcccattttc caaagacagc aagggttgct
     3601 cccaactcta ttttatcagc cagatagggc tggttaaaga aattcaccgc aaaaacgacc
     3661 tctccctgct tgagactaaa acgcaggcga ttgcgcttga aaccataata ctggacacta
     3721 gcaggagtca ctacctgacc agaaagaact gccttctcac cgtcttccag ctccagcacc
     3781 tgcttggttt tgaagtcttc ataacggaaa ggaaagtaga gcaagagatc ttgcaagttt
     3841 tcaattccta gtttggcgta tttttctgct gactttggtc ccacaccagg caagacatgc
     3901 aagggttgat gtagattcat gctccactcc tttcttttct aataatattc tctcggaata
     3961 cggtcgctga ggaggcaaac cacctcatag ttaatggtta cgcggtaggt cgctacctga
     4021 gttgcagtga tttccttatc cccattggag ccaatcaagg ttaccttggt tccgagtggg
     4081 taaggcttag gcaatcgaat agtgatttgg tccatcgaaa ccctgccgac aattgggcaa
     4141 gcttggccat ctaccaagac agagaaattt tgcatgtctc ttgtccatcc atctgcatac
     4201 ccgattggca cggtcgcgat gacttgctcg ctatccgctt gataagttgc tccatagccc
     4261 atgcaagctc cagctggaac tgtcttgaca tgaaccagag cagactccaa ggtcaaggcc
     4321 ggtatcaaat cataaggcaa atccaagacc gctccacttg gattgaggcc atacatggca
     4381 tctcccatac gaaccgcatt gaaaatagtc tctacatgcc aaagagtcgt tgcagaattg
     4441 ctagcatgaa ccagctctgg aacttccttc atactagcta aaatagtttt aaaccgttct
     4501 aactgggcat taaaatagtc atctgattcc tcatcagcag tagcaaagtg ggtaaagatt
     4561 ccttcaacac gaacaccgtg ttgttggagc aaatcttgag cctgctcaac ctcactggcc
     4621 tctctaaaac caatccgtcc catccctgaa tcaatcttga ggtggactgt caatccagtt
     4681 aggtccactt ccttatctaa gagtgcttga atccactcca gtccagccac tgtcaaggtg
     4741 aagtcatatt ctttagctag agcaacagct tcgatttcag aaactcctaa aatgaggatt
     4801 ggcttgctga gtccagcttg tctgagttca atggcttcat cgatattgga aacgcaaaag
     4861 ccatcaacat catcttgaat tgccttggca acggcaacag ctccatgacc ataagcattg
     4921 gccttaacca cagccaactt gagcgttcct tgagggatat gagcccccat ttgctgaata
     4981 ttttgtcgaa tagctcccag atgaatcaga gccttggttg gtctatgtgg actagctttc
     5041 atgattttcc tccaaaatga cactggctgt cacaaactga tcggtgtggc tgatagacag
     5101 ccaaatcttt cctgaaaatg gtgcctgact aaaataaggc gccccacgtt cattgttcaa
     5161 gacttccaaa tcctgaaaac cgagcttgct aatgcccgtt cccatagcct tggaaaaggc
     5221 ctccttagcc gaccagcgac cagctaaata ttctatttgc ctgcgtcctt tgagactggt
     5281 gaagcgctcc atttcctgag cggtcagtac acgcttagca aatccttcat gtcgtgtaac
     5341 tgcgctttct atcgaagcca attcttcgat gtcaattccg tgtccaacta tcattctcat
     5401 caaaaggagt tgagattccc caactccatc cttttcactt attttgtcaa ggtaacataa
     5461 atctcttcta ccaaggcctc tgtattttcc caacctaggc aagggtcagt aatagagcaa
     5521 ccaaagatct ctggttggtt ttgacgacca tctgctaggt aagattcaat cataaatcct
     5581 cgaaccgtct ttttaatttt ctcattccaa tcacgattct gcaaggtctg gcgaacaatt
     5641 cgaatctgct ccatatattg cttgcctgag ttatcatggt tggtgtcaat gaggataaaa
     5701 ggattttcaa gtcccatggt ttcatagcgt tcaatggctt ggagtaggtt ttcatagtag
     5761 taattcggca tataattgcc atactcgttg actgctccac ggaggataac atgggccaaa
     5821 ggattacctg atgtctcaac ttcctgccca tgataaagga aggtttgctt gttttgagca
     5881 gcatagatgg cgttaaacat aacacccaaa tttcctgagg ttggattttt catccctact
     5941 ggtgcatcaa tcccagaagc cacaaagcgg tgctcttggt cttccacaga acgagctcca
     6001 acggcatggt agctgaccaa gtcatccacc aagatcagat ttgacggata aagcatctca
     6061 tctgccgttg tcaaaccagt ctctgtaatc acgcggtagt gcaactggcg cacagcctgc
     6121 aagccattaa tcaggcttgg agccttagaa gtatctggct ggtgaactaa tcctttatag
     6181 ccgtctccat tggtacgagg cttagcagta tacacgcgca tgaccatgaa aatcttatcc
     6241 gctaccttct tttgcaaggc ggataaacgg cgagcatatt ccaagaccgc ctcttcatta
     6301 tcagaagagc aaggaccaat caccaagaga atacggtcat cttcccctga aataatatct
     6361 gccaattccc tgtcacggct ttccttgagt ctcaaggctt ccgcagacaa ttgggtttca
     6421 gccttgatga cttccatatc gatttcttga cctttttcaa taaatgccat cttattctcc
     6481 taacgttttg taaatttctc tgacaagagc ttctgtgtta tcccaaccca ggcaagggtc
     6541 tgtgatagac ttaccaaata cttctggctc attttgtcga ccatcttcca gataagactc
     6601 aatcataaaa ccacgaacga actgcttaat tttttcattc caagcacggt taatcaaggt
     6661 ctggcggaca attcggatct gttcaatata ctgcttacca gaattgtcat gattggtatc
     6721 aatgatgata aaaggatttt ccaagcccat tttctcatac tgggcaatgg tatcaattaa
     6781 attgtcataa tagtagttgg gaatattttt tccatactca ttaagagcac cacgaagaat
     6841 agcgtgtgaa agcgggttcc cagttgtttc tacttctttt cctaagaaaa ggaaactttg
     6901 tttgttttga gcagcataaa tcccattaaa catgacattg agatttccag aggttggatt
     6961 tttaaaacca gtagaaaatc ctgccccact tgccacaaag cggtgttgct ggtcttcaac
     7021 tgaacgggca ccaactgcca tgtaagaaat caaatcatct acaagcggaa ggttttcagg
     7081 ataaagcatt tcatcagcag ttgtcatccc tgtttctgtg atgacacgat agtgaagatg
     7141 gcgaacggct ttgattccat tgataagact aggcgcttct gtcgcgttag gctggtgaat
     7201 caagccctta tagccatctc cgttggtacg gggtttggca gtataaacac gcataaccat
     7261 aaagatacga tctgccactt cttcttgtag gactgccaaa cgcttagcgt attcaaggac
     7321 agcttcttcg ttgtcagatg agcatggccc gattaccaag agaattcgct ggtcttctcc
     7381 acgtataatg gcttctagct cttgatctcg ctgtgatttc ctctccaaag cctgaccttc
     7441 taattttgac aaggcacgaa cttcttctat atttatttta gagctttttg ctgtaaatac
     7501 cataactcat ctccttataa agcaaacgga tacccagtaa aaatttactt ttcacaagat
     7561 atccgcctct aaactatctc attttattgt cttttaccgt gacagttttt aaatttctta
     7621 ccagaaccac atgggcaaag ttcattgcgt ccaatctggc tcaaatccaa atcttctggc
     7681 atacttgctt ggtgagcagc gatattgcga gtcgctgttg tactgatatg acgttctgcc
     7741 tgtggtcttt cttgttcatg aatttgtgct ttcatcatca agcgtgtcac atcaaactca
     7801 atcgaaccaa tcatatcatt aaacatacgg aaaccttctg cctgatactc aacaacaggg
     7861 ttgttctgag catagccacg aagtccaacc gcgttacgca attgatcaag ggcatcgata
     7921 tgatctgtcc acttgttatc caccactcgt agaatcaaaa ctttttggaa ttctttaact
     7981 gcttcttcat cgcgtagttt tgaaacctga ctatcgtaaa ccttcaaggc acgttggaaa
     8041 agctcttcct tgatggcctt atcagacaag cctgacaagt cttccatcgt aatagaatct
     8101 tcaggaagca agttgtactt agcaaagttc aaaattgcct ctagtttttc atcttgtttg
     8161 gcacgcgcat gaccatcaac gacacgttca atcgtgcgct taatcataga ctgaatttca
     8221 ggtgccaagt cacgatctgc agtgatgata tcgtaacgtt gagcatagat aatctcacgt
     8281 tgttcacgca tgacatcatc gtattgaagg acttgtttac gggtatcgta gttatttcct
     8341 tcgacacgtt tctgagctgc ttcaacctga cgcgtcaaca tgcgagactc aatcgcctct
     8401 tcagacatgt tcaagcgttc aaagattccc ttcaagcgtt cagaaccaaa acgtttcatc
     8461 aaatcatctt caagagatag gtagaattgt gactcacctg gatctccttg acgacctgaa
     8521 cgtccacgaa gctggttatc gatacgacga ctttcatgac gttctgtacc aataacacaa
     8581 agtcctccaa gttcacgaac accttcacca agcttgatgt cggtaccacg acccgccatg
     8641 ttggttgcga tggtaacggc accacgttga ccagcattca tgatgatttg ggcttctcta
     8701 tagtggtttt tggcattcaa gacttcgtga ggaacaccag ctgcgaccaa tttcttagaa
     8761 atgtagtcac tagtttcaac cgctactgta ccaaccaaga caggttgacc cttttggtaa
     8821 cgagccttaa cgtcttcgac aaccgcttta aacttagatt cgatacttgc ataaagaagg
     8881 tctgagtggt caatacgttg aacaggacgg tttgttggga ttggaataac acgaatgttg
     8941 tagatttcac gaaattcttc ttcctcagtc ttacctgtac ccgtcatacc agacaatttt
     9001 ttgtacatac ggaaaaggtt ttggtacgtg attgaggcag atgtcttggt ttcatcctgg
     9061 attggcacac cttctttggc ttcaatagct tggtgcaatc catcagaata acgacgacct
     9121 tccatggtac gacctgtaaa ttggtcgaca atcaagattt cttgctcttc gctcaccaca
     9181 tagtcaatat cgagaagcat gatgtagttg gcacgaaggg cgttatcgat aaagtgggtc
     9241 aaagccacgt tttcgatgtc atagaggttt tcaagtttga agtagctttc agccctgtca
     9301 atccctgaat cagacaaacc aatagtctta gactgcacat cgatgatgta gtcatctttg
     9361 ttcaaagatt ttacatagtg gtctgccatg tgatacaact gactggtttc aaccgcattg
     9421 gcacctgata caatcaaagg tgtacgagcc tcgtcaatca agatagagtc aacctcatcg
     9481 accaaggcat agttaagcgg acgttgtacc atgttttcag cgcgaacgac catgttgtca
     9541 cgaaggtagt caaatccgat ttctgagtta gttgagtaag taatatcaca ctcataggct
     9601 tcttttttct ccattggaga tttggtagcc aagttaatcc ctactgacaa accaagccaa
     9661 gagtacaatt cacccatctc agtcgcgtca cgttctgaca ggtattcatt aaccgtaact
     9721 acgtgaaccc ctttacctga aagggcattg aggtataccg gcatggtcgc agtcaaggtt
     9781 ttcccttccc ctgtacgcat ctctggcacg tcaccatggt gaagaacaat cccccccatg
     9841 acctgaacct tataagggaa gagacctagg acacgtttgg caccttcacg gacaaccgca
     9901 aatgcttcgt aaagcaatga atccagtgat tctccatttt gataacgttc cttaaattca
     9961 actgtttttg cttttagttg gtcatcagtc aaagcagcca tttggtcttc gtatttgaaa
    10021 accttgtcag ccatcttttc cagacgacgg atttctcctt tatcattttc gataattgtt
    10081 tttaaaatat tagccatgtt tttccttact ttaaattccg aatattttag aatgttcctt
    10141 taattttagc acaattactg attattttca aggaagaatc cccattttga aaaggaaaaa
    10201 gaggttagtt ttcaagctaa cctctccgac ttttatgact gtttaattgc caaaaattgg
    10261 caaaatggca aatgtgataa ataagttaat ccaaagagaa agacagcaaa tcagtccaaa
    10321 aacaaagaga ctgactttct tggacagcaa ggccatcaaa atggacagaa ttccaaaaac
    10381 tagcaagact ttctgtatga tgaagatgtc aatccttacc cccagaatcg ctctatccca
    10441 agggataaag aagaaagaca gccagatcag cagaactaaa ccaatataaa ccttggaata
    10501 gcgtgtaata aatgatttta gatgtgccat aagccatctc ctaggattgt atatccttta
    10561 catttgtata tgtccatttt cgacaactaa tacatctgta caaaggtctg aaatatcttc
    10621 cgatatgtgc gacgtcagga taaccagacc attttctttt ttcaggtaag ataaaatgac
    10681 ctgtttggtt aacctcacac tcttctcatc caaagcattc ataggttcat cgagaaagag
    10741 tatagaagga gaggaaataa aggcttgaat caaggccatt ttttgctttg ttcccaagga
    10801 taaatgacgg tattcaacgt cttcaaattc ctgtaaatca tagtattgaa tccaataggc
    10861 aattcttttt tccgtaactt tagatgaaaa ataccttaac agttccaaat tttctctcag
    10921 ggataaatga gataaaaact cgactttttc aattaaaatt cctgcatcct gaatataatg
    10981 attttttatc ccgtaaactt tcccgtcttg aagaactttt cctttgtcaa acttaatata
    11041 accagcaagt atctttaaaa gaaccgtctt gccagatcca ttatcacctt taagtccata
    11101 aatttttcct gattgaaaca ccaaattcaa ctgatttaaa ataggtcttt tcccataaat
    11161 tttctgtcca tttataattt caagtctcat cgtttatact ttcttaaatt tctcttccaa
    11221 gcgactaaca atcaacataa ctaataagct taagagtagt aaatacactg ttacaatatg
    11281 atccatcatc cattcttgtc ccacaaatgc taaaaaatag agaaaaaagg aaaaaccagc
    11341 gcccgcacta atcagtgcta tcagataaga cagtagtaag tacaaaatca ttaactgagc
    11401 aagtaaaaag aaaagtgcga ctgttttgaa atgaattcct agcggaagta aaccaagaaa
    11461 ccagacaaac aaatcttgag taaaaaattt agaaatgaca accaatcgtt tccttgtata
    11521 atcgaaaaag gagcttgatt gatagcgaat caagtgatgg taatggtctg ccaaatcact
    11581 ttcaagtaaa atgacagaga gccatcctac catgaaaagc gaaaggttta acaagagttt
    11641 ggggatttct aaattcgctt cagaatagtc attataggaa aaaattgaaa tcaattctct
    11701 cttgaaaaag ataacagcat cctgcttttg aaccgctgtt gacaatagat ggtttatcaa
    11761 aatcatcatc agaactatac gaagtagtaa aacaatcttt ctctttagcc aaatattgtt
    11821 aaaattctta aacattatct tcatattttt caagcaccat ataagggaca acataaagga
    11881 tataaggagt aaagagtttc atcaaactta catccccata gctagcttgc atcaaactcg
    11941 tcataggaac catatagtaa ggcaaggcac tatagagcag catagaacca agccaaagaa
    12001 acatcaaata ggtgattgcc gaacgagtca cattccccac ataatcaact atttgtaaaa
    12061 aatagattgc attgatgaaa ataccgatta gtaggacaca agtaaagaac aaatagcttt
    12121 ttatctctcc atctaggagt ctttgtaaac cacttccatc agaaaataga gaattccatc
    12181 caagaggaga aaaagtccca aagaaatagg ttacaattgc aattatcagc acagtcacta
    12241 aatatatcaa acaagggata cttgcaactt gcaaagtcaa ctttcttttt aacccttgat
    12301 aactcacttc tcttccaata ctcaatcgta aaactttatt tttcagctca atatattgaa
    12361 aacctagcaa aacaatgatg attggaataa taaatgattg ataaaaacct agattgaact
    12421 ggagaatacg aaaatctaat gctgatttta ataagtcatt tttaattgct tgtccatcga
    12481 atttagctag atcgggcgca tgaatatcaa aaaagaaata agtcatcaaa acatcacgat
    12541 aaaccaaagc aagaaaaagc aaagtaagca agacataaac aaatttatgc cttgccaaag
    12601 ttaagagagg aatcttcata agccacctcc tacaaataga aagtaatata atactcaatg
    12661 aaaatcaaag agcaaactag gaaactagcc gcaagttgct caaagcactg ctttgaggtt
    12721 gtagataaga ctgacgaagt cagttacata tataatccaa ggcgacgttg acgtggtttg
    12781 aagagatttt cgaagagtat aaatcaatgc cttccgcctt tagacttccc tagttcccgt
    12841 ctcaagtcaa gcattttttt gaaacagata tagtctaacc agtcactagc aaaagcgata
    12901 agtagtaata atagccaaat accccataac ttgatatctg tcaaatttct caagacgata
    12961 ttgaaaaaca gaactgaaaa aactgtccaa gaaaggctaa aaagagcata gagggggatg
    13021 taaatccagt aaaaatagta aaaaattggg aaaaatttac tttctctatt atccttgtca
    13081 atccagctga aaaagtaaaa acagggtaat aagattatca ttttaaacaa gtgttccatc
    13141 acaagcctcc ttttttaaat tgttttcttt agtttcgttc tattaaatgt tattaccaat
    13201 ataaaccttg gaatagcgtg taataaatga ttttagaggt accataagcc acctcctaca
    13261 aatagaaacc gatataaatc aatgccttcc acccttagac ttccctagtt cctgtctcaa
    13321 gcgaaacatt tctttgaaac aggaataagt taaccaattc ataccaatag ctagcagaat
    13381 aaaaagaaac caaatgcccc ataacttgat atctgtcaca tttctcaaga cggtattgaa
    13441 aaacagaact gaaacaactg tccaagcaag gctaaaaaga gaatagaagg ggatgtaaat
    13501 ccagtaaaaa taataaaaaa ttggaaaaaa cttactattt ctgttggcct tttcaatcca
    13561 gttatcaaaa taaaagtacg gtgctaaaag taagaattta aacaaatgtt ccatcaccga
    13621 catccccctc cttcttttga tagcgttttc tattatttta ttatatcaaa agaatctgga
    13681 aatgtcattc cagattctac ttttttattt acgctttctt gcgatgagat gaatcggtgt
    13741 tccctcaaag acaaaggcct tgcggatttg attttccaag aaacgtaggt aagaaaagtg
    13801 catgagttct tcttcgttga caaagataac aaaggttggt ggtttggttg ccacttgggt
    13861 cgcatagaaa atcttgagac gttttccttt gtctgtcggt gttgggttga tggcaatggc
    13921 atccatgatg acatcgttca agacagctga tggaatacgt gtattttgac tttcgctgat
    13981 ttgcttaatc atcccaggaa gtttgtggag acgttgcttg gttaaagctg atacaaagat
    14041 aatcggtgcg taaggcaggt attggaactg ctcacggata tcttcttccc agtttttcat
    14101 agtgtggtta tctttttcaa gcgtatccca cttgttgacc acgataatca tccctttacc
    14161 agcttcatga gcaaatccag cgatacgctt gtcgtattca cgaatcccct cttccgcatt
    14221 gatgaccatt aagaccacat ctgaacggtc aatagcacgc atggcacgca tgacagagta
    14281 cttctcagta ttttcataaa ccttaccaga cttacgcata ccagccgtat caatcatggt
    14341 aaactcttga ccatctgtat ctgtaaagtg ggtatcaatg gcatcacgag ttgttccagc
    14401 aacagaactg gcaatgacac ggtcttctcc caagatagca ttaatcaagc ttgattttcc
    14461 aacgttagga cgaccaatca agctaaactt aatgacatct ggattttctt cttcatattc
    14521 atttggaagg ttttccacaa tcgcatctag tacatcccct gtaccgattc catggacaga
    14581 tgagataggc agtggttcac ccaaaccgag agcatagaaa tcatagatat catttctcat
    14641 ctcagggttg tccaccttgt tgactgcgag gataactggt ttgtgggtct tataaagctt
    14701 acgagctacg tattcgtctg catcagtaat tccttcctta ccagacacga caaaaacgat
    14761 aacatctgct tcttccatgg caatttctgc ctggtgcttg atttgttcca tgaaaggagc
    14821 atcgacatca tcaattcctc ctgtatcaat catactaaaa gagcgattga gccactcacc
    14881 cgttgcatag atacggtcac gtgtcactcc ttcgacatct tctacaatgg agattcgctc
    14941 accagcgatc cgattaaata gggttgattt cccaacattg ggacgtccta caatggcaat
    15001 agttggtagg gccataattt ctcactttct acaataactt cttctgttta agattttttc
    15061 tagttgagct tggttctgct tggccaaact gttctgctag acgctgactc cagcttgtgg
    15121 tcgcacgcgc tccagcatag tcagcctgaa cacggtcata agcttggatt gcctcagttg
    15181 actgttcttg gtattcttcc tcaaagacaa cattctctag tggcagtctc ggtttcatat
    15241 catgatgttg atttggcaca cccagtgcca tcccaaagac agaataggtg tagtcaggta
    15301 ggttaaagag ctctgccact tcttcagact tgtatcgaac caaaccgata atcacaccac
    15361 catagcccaa gctttcagct gccaacaagg cgttttgtcc agcaagagct gcatcgaccg
    15421 aactaatcaa gagaccttcc acaccttggg gttggaaggt gtcggtatga agtcgggctc
    15481 ccttttctgc tcggttcaaa tctccgacaa agagaaggaa aacagcagac tggcgaatgg
    15541 cttcttgagg taccaattca tacaaggcat ctttcttctc ttgacttcgt accacaatca
    15601 cagagtagga ttggaaattc ttccaagatg atgccatctg ggctgctgtc aaaatctcat
    15661 ttaagtctac ttggggaatt tcttgctctt taaacctgcg cactgaagta tgagccttca
    15721 tcaatttaat ggtttctgtc atcgacggtt tactccttct aaacgagtct cctcagccaa
    15781 ataacggatg cgttccatga cacgtctggc ttcccaggtt tcgtcatttc catttttccc
    15841 tttagcgaaa tgcttctcca aatcttcaaa gttgaagtta gaggtgaaaa aggtcggtaa
    15901 attttcctgc atccgatatt ggagaatgac ctgcaggatt tcatcacgca cccaagcggt
    15961 ggattgctcg gcaccaatat catctaaaat caggacttca gaaagcttaa tctcatccac
    16021 taaggtctta acattgccat caccgatagc atttttgaca tcaatgacaa agctaggata
    16081 gtggaggaga gtggatgata caccacgttt ttctgataaa tcatgagcta gggcagccac
    16141 catgaaactt ttacccacac caaagtctcc atataagtaa agacctttca aattattggg
    16201 gtaatcgtta acaaattcta tcattctttt tagaacagtt aagcgctgaa catcatcacg
    16261 ataaacatct aaaaaactga catttttcag gctagatgga aaattaatta agttgagacg
    16321 tttcttgata gccgcttctt tttcagctgc gattagttca ggagtttctt cataagaaac
    16381 atccgcatag ccatggttca tgactaatat aggcttgtag cctttggcaa tataatctgt
    16441 atctcctcgg aggaatttat ctctctcagt gatgtattgg ttaaacttgg aaatactacg
    16501 gttcaactcg tcctgattga gggattcttg ctggacaaag gccgcaacat caggatcctt
    16561 catgattttc tgaactaaat cttgatagtg aaaacgactt ggttgacgtt tgagtacatc
    16621 tccgacactt tccatctaat cacctccgtt atctaatttt gctaataatt ctagggtttg
    16681 gcgttccatc tcttctaatt cctcagcgga tgacgtattt ttatattcag gattactcca
    16741 tttaggaata ttggtttttg ctggggcagt ctgattctgt ttttgtgttt ttgttttctg
    16801 ccctcgctca cggatgcgca agactgcctt ttctgccgaa tgaatctttt gataggcata
    16861 gtcattggct accttcatgg catatttctc attgatattt gccgaatcga ccttattaaa
    16921 ggtcaataaa agaatgatat tgatgacttc gtccagcaag cccaagccag ccatctgttg
    16981 caagagttct ctttctgttt gggtaatggt tcccttgcgt gtttgcttga tttctgccaa
    17041 gaactgcagg gcagttttac ttttggcttc tttgataatg gttgtttcct taagactaaa
    17101 gtcagaggaa actggttttt gagcaatttt ttcacgcatg cgtttggttg aaataacctg
    17161 agaaacagct gttgacttgg ccaattgata ggtttcaaac caagtccatt tcttctcctc
    17221 ggcaatagca aagaggttta agacatcgga ctgctcatcc gcaaaacgaa gtccatctcg
    17281 agccatcagc tggcgaaaat gttccaagtc aaaatcattg gccactttct tcttgagacc
    17341 aaggtcttct tgactgccta gttctgccaa ttctggaaag acttgattga gtgagacagg
    17401 tatttcttca ccatcagcac tttcaacttt caaatcctcc acagcagagt cgccaatctt
    17461 tttctctaag agtctgcgat aaacaggatg ctccaagaag tcttgactag atagaggagc
    17521 atggagggct agctgataaa catccccctt ttgatagagg gtcaagagat taaaagcaga
    17581 taagattttc aatgatttta tcagtctatc catcccaaag ttgagatgat tgaggatact
    17641 tgaaaaaaga tattcctttc taccattatc ccaaaaactg attgtataaa gataaaggct
    17701 cagtgcctcc tgaccgataa tcgggaggta gcactgtacc agagatgagg tatcttgcga
    17761 cacccgatta ttctttagat aagaaaaacg gtcaattggc ttcatttatc tttccttttt
    17821 ctttttagag gactgggtga tttgttggag caagctctct aactcactga catccttaaa
    17881 actacgatag acactagcaa aacgtacata ggtaatctcg tccaattcag ccaactcctc
    17941 catgacaagt gaaccaatgt cctcactttg aatttcattt tcatttcgac cacggagttt
    18001 ctgttcgata cgattgacta ccatgttgat ttcatcactt gacacaggac gtttctgggc
    18061 tgagcggata atcccattaa agattttatc tctggagaat tgttcccgtg tgccatcttt
    18121 tttaacaacc actaaggttc tttcttctac tcgttcgtag gttgtaaaac ggtgttggca
    18181 ctcgtcgcac tctcgtcttc tacgaatggt gttcccttct tctgcttggc gactatcgat
    18241 aacacttgac ttggtagccc cacattttgg acaacgcatc ctttccctcc ttatcgtttt
    18301 cttttcatta taccattttt taagcgattc ccaaaacaat tcttcttttt gcttgacaag
    18361 ttttttgttt tgttgtatta tttaattaag acaaaaggat aagagaaagg agactaagat
    18421 gtcctggaca tttgacaaca aaaaacccat ctatttacag attatggaga aaatcaagct
    18481 tcagattgtt tcccatacac tggaacccaa tcaacaactt ccaaccgtga gggagctagc
    18541 tagcgaggct ggtgtcaatc ccaataccat ccaaagagcc ttatcagacc ttgaacgaga
    18601 aggatttgtc tacagcaagc gaacaactgg acgatttgtg actaaggata aggagctaat
    18661 cgctcagtca cgcaaacaat tatcagaaga agaattggaa cacttcgttt cctccatgac
    18721 ccattttggc tatgaaaaag aagaactacc aggcgtagtc agtgattata ttaaaggagt
    18781 ttaagcctat gtcattacta gcatttgaaa atgtatccaa atcatatgga gcaacaccag
    18841 cccttgaaaa tgtttctctt gacattccag ctggaaaaat tgtcggcctt cttgggccaa
    18901 acggctcagg aaaaacaacc ctgattaaac taattaatgg cctcttacaa ccagatcaag
    18961 gacgtgtcct catcaacgac atggacccaa gcccagcaac caaggccgtt gtagcttatt
    19021 tgcctgatac gacctatctc aatgagcaaa tgaaggtcaa agaagcccta acctacttca
    19081 agaccttcta taaagatttc aatcttgaac gcgctcatca tctacttgca gacctgggca
    19141 ttgatgaaaa tagtcgtctc aagaaactat caaaaggaaa caaagaaaag gttcaactga
    19201 ttttggttat gagccgtgat gctcgtctct atgttttgga tgaacccatt ggtggggtgg
    19261 atccagcagc ccgtgcttat atcctcaata ccattatcaa caactactca ccaacttcta
    19321 ccgttttgat ttctacccac ttgatttctg atatcgagcc aatcttggat gaaattgtct
    19381 tcctaaaaga cggaaaagtc gtccgtcaag gaaatgtaga tgatattcgc tacgagtcag
    19441 gtgaatccat tgaccaactc ttccgtcagg aatttaaggc ctaagcaaag gagattattt
    19501 atgttttgga atttagttca ctacgaattt aaaaatgtta acaagtggta tttagccctc
    19561 tacgcagccg tgctagtcct ttctgccctc atcggaatac agacacaagg ctttaaaaat
    19621 ctaccttacc aagaaagtca ggctactatg ctactttttc tagctacagt ctttggtggc
    19681 ttgatgctta cacttgcgat ttcaaccatt ttcttgatta ttaaacgctt caaaggtagt
    19741 gtctacgacc gacaaggcta tctgactttg accttgccag tttctgaaca ccatatcatc
    19801 acagccaaac taatcggtgc ctttatctgg tcattgatta gcaccgctgt attggctcta
    19861 agtgctgtta ttattctggc tttaacagct ccagaatgga ttcctctttc ttatgtgatt
    19921 acatttgtag aaacacatct ccctcagatc tttcttacag gtatatcctt cctactaaat
    19981 accatttcag gaatcctctg catctacctg gctatttcca ttggacagct tttcaatgaa
    20041 taccgtacag cactcgctgt tgcagcctac attggtatcc aaatcgtcat tggatttatt
    20101 gaacttttct tcaatcttag ttccaatttc tatgtcaatt cactggtagg actcaatgac
    20161 catttctata tgggagcagg tatagccatt gttaaagaac tcatattcat agctatcttt
    20221 tatctcggaa cctactacat cttgagaaat aaggttaatt tgctttaaat aatttttacc
    20281 tagatatgta acatactcat agaacaaaag agaccaggca aaaagtcttt aaaattagaa
    20341 aacgcatagt atcaagtgtt aaaaatcctt gatattatgc gttttttgtg agctgactta
    20401 tttcctttcg ctatatcgca aaatgaaata agaacggaac gatgggattt tggaattcaa
    20461 atcaatttat aagaatgttt tagaagtaat attatcctat tccagattca gttcactata
    20521 caattgagtt ttcaagcaac ctgtttacat aatgtgtaca taattaggtt cgtgattcca
    20581 cccttttcac ctttaaaaac ctcgctttcg caaggctctt ctatttataa gataaggcac
    20641 gtttaaaggt tttccaaatc cctaaatcat ccgtttgaag aacgagacta gcatacatgc
    20701 gtccgataaa tcctgttgct accaccgcaa aaatcactgt aatagcaagt gaaatccatg
    20761 cttccgctcc ctccgcatag ccattaatcg ttcgaaacgg cataaagaag gtcgaaataa
    20821 agggaatata agaaccaatc ttcaagagga gattgtcacc agctgcacct agagctgtca
    20881 ctccaaaaaa accacccata atcaaaatca tcaaaggcga caaggctttc cctgagtcct
    20941 caggacgaga aaccatagat cctaggaagg ctgccaagac tacgtacatg aaaagactga
    21001 tcaaaataaa gagcagggta ttcagtgaga tagcatctcc caagtgatcc aaaataccag
    21061 actgagccaa gaatggcaaa tctttaaaga gcaaaacggc agccagacca cctacaacat
    21121 agatcccaat atgcgttaaa atcactagaa acagagccat catccgcgca tagaaatagt
    21181 gacttgccct tatgctagaa aagacgactt ccataatttt ggtgcctttt tcactggcaa
    21241 cttcctgagc tgttacaccc gcataggtaa tcagaatcat ataaagaaag aatcctaagg
    21301 cacctgctgc aattgtttga ataaactttt tattttcctt ggcttcatca atcttttctg
    21361 tgaattgaat tgtctgcgct aagcgttttt cctgctcttg agacaaggaa gcagttgaac
    21421 gattaagctg attttgcagt tcattgagtg tacctgtaac ctcaaattta attccatttt
    21481 caagcgatgt ttcgccatga taaactgcct ttagaacact atcttcttga tcaatggtca
    21541 aataaccttt taatttttct tctttaattg cttctttggc acttgcttca tctttatagt
    21601 cgaagttaac accatttaca ttcttcagtc cttctgctac agatggcact gttgtcacta
    21661 ctgccacttt attattttta gccatagaag aaccttggag atgcccaatt cctacagaga
    21721 ttcctaaaaa gaggaacggc gaaatcacca taaagaagaa actccatgac tcgacatgtc
    21781 gaagataggt ttccttgatt acaacccaca tatttctcat acttccactc ctgattctag
    21841 tttaaagatt tcatcgatag ttggcgcttg ttggtcaaat gttgcgatat attgaccttg
    21901 agtcaagatt gggaagagtt cccttccagc gctctcatcc tccaaaatca atttccaact
    21961 gccttgtttg gtcaagctca cctgtttgac atgaggaaga ttttccaatt cttccttgct
    22021 tcgttcactt gaaacaaaga gacgcgtttt cccgtattga ttgcggacat cctgaactgg
    22081 tccgtgcaag accacacggc catctcggat catcagaata tcgtcacaaa gttcctcaac
    22141 attggtcatg acatggtcag aaaagataat ggttgctccg cgctcttttt cctgaaaaat
    22201 gacttgtttg agcaattctg tattaactgg gtccaatcca ctaaaaggct catccaagat
    22261 aatcaggtct ggttcatgaa tcagagtaat aatgagctga atcttctgct gatttccttt
    22321 tgacagactc ttgattttat ctgtcagctt tcctttcact tccaacctct tcatccattg
    22381 agggagtttt tctttgactt ctttggcatc catgcctttt agagtcgcca agtagcgaac
    22441 ttgttcaaga actgtcaatt taggcatgag actgcgttct tcaggcagat aaccaatccg
    22501 agcataggtc tcctgacgaa tatcctgacc atccagaccg atttctccct gatattctag
    22561 gaatttcaaa atactatgga aaatcgttgt ttttccagca ccattttttc cgactagtcc
    22621 caaaatacga cctggtcgcg cttgaaagtc aataccaaac aaaacttgct tggagccaaa
    22681 acttttctct agacttctta cttctagcat ctttcacctc cgaaatttct tgcactcatt
    22741 atactccttt ttgatagcct ttacaatgtt tttgtccatt tttagaagac tattgctgtg
    22801 taaaatatgg cctggagcac ttttatactc aatgaaaagc aaagagcaaa ctaggaagct
    22861 agccgtaggc tgctcaaagt acagctttga ggttgcagat aaaactgacg aagtcagctc
    22921 aaaacactgt tttgaggttg tggatagaac tgacgaagtc agtaactata tctacggcaa
    22981 ggcgaagctg acgtggtttg aagagatttt cgaagagtat tagtgataaa tccattatac
    23041 agtagcaaac ttaatttata ccttccgctc ctcaactgtc tatttttaat cctgaattgt
    23101 tatttgagta actccttttt cctcataaag ttttcttcct ctaaaacttc tggaaaaaag
    23161 cgaatagttt cagacaacat ttttataaga aacaagttca tctgtcattt caagaaggag
    23221 taatccttta tctactaatg gacggaacgg aattcaaccg cttgtccgat atgttttcta
    23281 aggattatat agcaaaatga aataaaaaca ggacaaatag atcgggacag tcaaatcgat
    23341 ttctaacaat gttttagaag tagatgcgta ctattctagt ttcaatctat tatatctatt
    23401 atgcacacca ctataggatc taataaaaat cacaacaagt tcattcatag atggttacct
    23461 cagggaacta agaaaacgac tacaaaggaa gtcgcattca tcgaaaagtg gattaacaac
    23521 tatcctaaaa aatgcttgaa ctacaagtcc cccagagaag acttctggat gactaacttg
    23581 aacttgaaat ttagcaataa ttaattcacc atctaactat atttagtaat tatttcagaa
    23641 ctgattaata ttaaaattaa ctaacaattc aaaggattca tactagccat aaattacgtc
    23701 catcagagag agactcttac tacttttaga ttttagtctt tctagcttca gaatacatct
    23761 aaactttagg gaaaatgact attcgaaagc gcgaatgcct caaaattatc tcagataagc
    23821 tattcgaaac ttagaatgct tttaaattca tggaattgcg attattcgaa acctagaatg
    23881 catataacct ttagttgaca gacctattct aagtctcgaa gggctattta ctttctattc
    23941 cttatcaaaa aagactcatt ccccctttct cctccaaaat atggtatagt agaaatatac
    24001 tatctatgag gagtttacat gtcacaggat aaacaaatga aagctgtttc tccccttctg
    24061 cagcgagtta tcaatatctc atcgattgtc ggtggggttg ggagtttgat tttctgtatt
    24121 tgggcttatc aggctgggat tttacaatcc aaggaaaccc tctctgcctt tatccagcag
    24181 gcaggcatct ggggtccacc tctctttatc tttttacaga ttttacagac tgtcgtccct
    24241 atcattccag gggccttgac ctcggtggct ggggtcttta tctacgggca catcatcggg
    24301 actatctaca actatatcgg catcgtgatt ggctgtgcca ttatctttta tctagtgcgc
    24361 ctatacggag ctgcctttgt ccagtctgtc gtcagcaagc gcacctacga caagtacatc
    24421 ggctggctag ataagggcaa tcgttttgac cgcttcttta tttttatgat gatttggccc
    24481 attagcccag ctgactttct ctgtatgctg gctgccctga ccaagatgag tttcaagcgc
    24541 tacatgacca tcatcattct gaccaaaccc tttaccctcg tggtttatac ctacggtttg
    24601 acctatatta ttgacttttt ctggcaaatg ctttgacacg taaaaaatcc gtttggtttc
    24661 ccaagtggat tttgtgcttt attttgaaac ttcttttgca agaacaaagt tcccaagtgt
    24721 ggcagaacca tttcctgcga ctgctggcgt cacgatatag tcacgcacat ctggtactgg
    24781 taggtaacca ttaagaagag atgtaaattt ctcacggaca cggtccagca tatgttgttg
    24841 agccatgacc cctccaccaa agacaatcac gtctgggcgg aaagtcactg tcgcattaac
    24901 cgcagcttga gcgatatagt aggcttgaac atcccaaaca gggttgttga gttcaatagt
    24961 ttccccacgt acacctgtac gagcttccaa acttggacca gctgcataac cttctagaca
    25021 tcccttatgg aaaggacaaa cacccttaaa ctctttttca atatccattg ggtgtctagc
    25081 aacataataa tgacccattt cagggtgacc cacaccaccg ataaactcac cacgttggat
    25141 gacgcctgca ccgatacctg taccgattgt gtagtaaacc aagttttcga tacgaccacc
    25201 agcattgtta cgggcaacca tttcaccgta agcagagctg tttacgtctg ttgtgaagta
    25261 cattggcacg tttagggcgc gacgaagggc accaagcaag tctacatttg cccagtttgg
    25321 ttttggagtc gtcgtgataa agccataagt ttttgagttt ttgtcaatat caatcggccc
    25381 aaatgaacca actgcaagac cagcaaggtt atcgaatttt gagaagaact caatggtttt
    25441 atcgattgtt tcgattggag ttgttgttgg aaattgtgtt ttttctacaa cgttaaagtt
    25501 ttcatcaccg acagcacaga caaactttgt accgcccgct tccaagcttc catataattt
    25561 tgtcatgata aacctcttgt ttttattttc tttattatag catacttcga aagtctaaat
    25621 gtctctattt tttagatttt cctctgtaaa tcttactatc taataaaaac gaacaaacat
    25681 gtcatttgtt cgttttcaca ttagagagga ttgattagat tttcacttcg atcacagcat
    25741 cccccttcga aactgaacct gttgcgactg gagctactga agcgtagtca gctgtatttg
    25801 taacgataac cattgttgta tcatcaagtc cagctgcagc gattttgttt gagtcaaatg
    25861 ttccaagaac atcgccagct ttcaccttat taccttgagc aacttttgct tcaaaaccgt
    25921 caccgttcat agatacagtg tcaataccaa cgtgaatcaa aacttcagca ccatttcttg
    25981 ttttcaaacc aaaagcgtgc cctgttggaa aggcaattga aacttcagca tcagctagtg
    26041 catagaccac gccttgactt ggtttcacag cgataccttg tcccatagct ccacttgaga
    26101 agactgggtc attgacatca gcaagagcga caacatcacc gacgatagga gttacaagtg
    26161 tttcattttg aagagctgct ggcgcaactt cttctttttc ttcagccact tcagcttgtt
    26221 ttgcagctgc agttgcgtct acttcatctt cgtaaccaaa catgtaagta agagcaaaac
    26281 caagggcaaa tgatacagct accataagaa ggtattgtgg aagttgtccg ttaccaacat
    26341 aaagcattgt accagggatg atggtgatac cattaccagt accagcaagt ccaaggatag
    26401 aagccaatcc accaccgatt gcaccagcaa tcaatgaaag gaagaatggt ttacggaagc
    26461 gcaagttcac cccgaagata gcaggctctg taatacctag gaaggcagaa agagcagccg
    26521 ggaaagcaag tgttttcagt tttggatttt ttgttttaac accaaccgca acagtagcag
    26581 caccttgagc tgtcatagca gctgtgatga tagcgttgaa tgggttagca tggtcagcag
    26641 caagtaattg cacttcaagc aagttgaaga tgtggtgcac acctgacacg acgatcaatt
    26701 ggtgaacccc accaatcaag aaaccaccaa gaccaaatgg catgctaaga atcgcttttg
    26761 tagcaataag gatgtagttt tcaacaacgt ggaaaactgg tccaataaca aagagtccaa
    26821 ggatagacat gaccaaaagt gtcacgaatg gtgttaccaa gaggtcaatg acatctggaa
    26881 caaccttgcg gacagctttt tcaaatttag ctccgacaac cccgatgatg aaggctggaa
    26941 gaacggaacc ttgcaaacca acaacaggga tgaaaccaaa gaagttcatc gctgttactt
    27001 caccaccttg agcaactgcc caagcgtttg gaagtgagcc agagacaagc atcataccaa
    27061 gaacgatacc aacggcagga tttccaccaa atacacggaa ggttgaccac acaaccaaac
    27121 ctggcaagat gatgaaggct gtatctgtca agatttgtgt gtaagttgca aagtcacctg
    27181 gaagtggcat ttcaagagcg ttgaaaagac cacgcacacc catgaagaga cctgtcgcta
    27241 cgataactgg gatgattgga acgaaaacat caccgaaagt acggatagca cgttggaacc
    27301 agttcccttg tttagcaact tctgctttca tgtcatcctt agatgatgtt ggtaagccaa
    27361 gtacaacaac ttcatcgtac attttgttaa ctgtacctgt accaaagata atttggtatt
    27421 gccctgagtt aaagaaagca ccttgaactt tttccaagtt ctcaatcact tctttattga
    27481 ttttctcttc atctttgacc atgacacgta gacgagtcgc acagtgggca acactattga
    27541 cattttcacg tccgcccaag gcatcgatga ctttttttgc aatttcctga ttgttcattt
    27601 gcaaaaatct ccttatataa cattttgttc ttgtttgaaa gcgattttat tcgcccttac
    27661 gactattatt ttatcatgtt ttaaaaatat gtcaagcgtt ttgcagaaaa aatattctat
    27721 ccacttagtg ggcaagtttt agattgattg tttttgactg tttcatcagg aattccttga
    27781 aaaataagtt tgaaaccttg gttaaaaagt attttatttc attatctttc acattttcgt
    27841 aaaaatttga ttgatttcct gtatttattt catgataatc gtttgacagt tttttctatt
    27901 ttttaatata aaaggcttgc attttttatc gaaaacagtt actattaaaa gtgataagat
    27961 ttttggagga atgaatggaa tggacaactg agcgtcgtta cagactttat caagattgga
    28021 cgcaagaaga aattcaacat ataaaggaaa atatggcaca atctccatgg catactcatt
    28081 accatgttga gccaaaaaca ggacttctca acgacccaaa tggcttttct tactttgatg
    28141 gcaagtggat cctcttttac cagaattttc cttttggtgc agcccacggt ttaaaatctt
    28201 gggcacagct agaaagtgat gatttggttc actttagaga aactggagtc aaagttttgc
    28261 cagatactcc attagatagt cacggtgcct actctggttc tgccatgcaa tttggcgata
    28321 acttattcct attttataca ggaaatgttc gcgatgaaaa ctggatccgt cacccatacc
    28381 aaatcggtgc tttgatggac aaggagggta agattacaaa gattgacaag atcttgattg
    28441 accagccagc agactctact gaccacttcc gcgatccaca aatttttaac tttcagggtc
    28501 aatattatgc cattgtcggc ggacaagact tggagaaaaa aggtttcgtt cgtctctaca
    28561 aggctgtcaa taacgactac acaaactggc aagcagttgg caaccttgac tttgctaacg
    28621 accgtactgc ctacatgatg gaatgtccta atctggtctt tgtagaggaa cagcctgtcc
    28681 ttctctactg tccacaagga ttggataaga aagttctaga ctacgataat atctttccaa
    28741 atatgtataa gattggggct tcctttgacc ctaaaaatgc caaaatggta gatgtgtctc
    28801 aacttcaaaa catggattac ggtttcgaag cctatgcaac tcaagccttc aacgctcctg
    28861 atgggcgtgc tctagcagtt agctggcttg gtttgccaga tgtttcttac ccatctgacc
    28921 gttttgacca ccaaggaacc ttctctttgg tcaaggaact cactatcaaa gacgacaagc
    28981 tctaccagta tccagtcgct gctattaagg accttcgtgc ttctgaagaa gccttctcaa
    29041 accgttccca aaccaagaac acttacgaac ttgaactcaa cttggaagcc aatagccaga
    29101 gcgagattgt cttacttgct gataaagaag gcaagggact ttcaatcaac tttgaccttg
    29161 taaacggtca agtgacagtg gatcgtagcc atgctggaga acagtatgcc caagaatttg
    29221 ggacaactcg ttcttgccct atcgagaatc aggctactac tgctacaatc ttcatcgata
    29281 actctgtctt tgaaattttc atcaataaag gagaaaaagt attttctggt cgtgtcttcc
    29341 cacatgcgga ccaaaatggt atcctgatca aatctggaaa cccaactgga acttactatg
    29401 aattagatta tggtcgcaaa actaactgat gtcgccaaac ttgcaggcgt cagtcctact
    29461 accgtttctc gggttatcaa taaaaaagga tatctatctg agaaaaccat ccaaaaagtc
    29521 aatgaagcca tgagagaatt aggctataaa cccaacaacc tggctcgtag tctgcaagga
    29581 aaatcagcta agttaatcgg cttgattttc cccaatattt ccaatgtttt ctatgcagaa
    29641 ttgattgata aattggaaca ccaactcttc aaaaatggtt acaagaccat catctgcaac
    29701 agtgaacatg attctgagaa ggaacgtgaa tacatcgaaa tgttggaagc caatcaggtg
    29761 gacggcatca tttctggtag tcacaaccta ggaatcgaag actacaatcg tgtgacagcg
    29821 ccgattattt cctttgaccg aaacctatcg ccagacatcc ctgtcgtctc ctctgacaac
    29881 tatgctggtg gggttcttgc tgcccaaacc ttggtcaaga caggtgccca gtctatcatc
    29941 atgattacag ggaatgacaa ttctaattcg ccaaccggac tgcgccacgc tggttttgca
    30001 tccgtactcc caaaagctcc tattatcaat gtttccagtg acttttctcc cgtcagaaaa
    30061 gaaatggaaa tcaagaatat cttgacccgg gaaaaaccag atgccatttt tgcttcggat
    30121 gatttgacag ctattctggt cattaaaatc gctcaagaat tgggcatttc tgtcccaaaa
    30181 gagctcaagg tcatcggcta tgatgggacc tactttatcg aaaattacta ccctcaattg
    30241 gctactatca agcaaccttt ggaagagatt gcttgtctca ctattgatct tctcttgcaa
    30301 aagattgaag gcaaggaagt cgccacaact ggttacttct taccagttac gctattacca
    30361 ggaaaaagta tttaaacaca agaaaactca gaccgattcg tctgagtttt tatgatctta
    30421 aattttcgag atagcgctgg gctgtctcta ggttaaaggt tttatctgcg ataagctgct
    30481 cgactagggg agcaacttca gattcactag ccccagctag gagagctagg gatttggcct
    30541 gtagtttcat gtggccttgc tggatgcccg tacttaccaa ggctttgagg gctgcaaaat
    30601 tttgagcaag accgatggac acgataatct gggctaattc tctggcagaa ggatttccta
    30661 gtagatcatg actgagaact acacgtgggt tgaggccgat agagccaccc ttagtcgcta
    30721 caggcatggg cagggtcatc tcaccgacca attcttctct ttcaaggtcc agcgtccagc
    30781 aactaagacc ttgataacgt ccatctcgac tggcaaaggc atgggcccca gcttcgatgg
    30841 cacgccagtc attaccagtg gcaatcaaaa tcgcatcaat accattaaaa attcctttat
    30901 tatgagtagc agctcggtaa ggatcagcct gcgcaaactg actagccaac gcaattttct
    30961 ccgcaatctc tcgtccttga tccttttggc ggctcaagta gcgaaaggcg atgcgacagc
    31021 ttgcagtcac cagagaatcg gtcgcgtagt tggacaggat tgccatgaga ctctgtccct
    31081 gactgagttc ttctaagact ggtttcaagg cttccagcat ggtgttgagc atattggcac
    31141 ccatggcttc ctgggtatcg acatgaatat aaacaacgag aaagtctggt tcacctttta
    31201 tctgctcgac atgcagatca cgcgccccac ctccacgttt aacgatagaa ggataggctt
    31261 gattggcaag ctccaagagc tccgctttct tgctggcaat cttctcttgc gctagtttag
    31321 gattagcaac ttgataaagg gctacctgcc caatcatctg tcgctgatgg acttgtgcag
    31381 taaaaccacc tgcacgcttg atgattttgc tggcatagct ggccgccgca accacagagg
    31441 gttcttctgt cacataggga acggtgtatt cctgaccgtt gacaagtacc tccggaacca
    31501 gtgaataagg cagagaaaaa gttcccacta cattctcact cagctggtct gccacagtca
    31561 cgctcatctg ttcatccttc tccagactag cttgtctctc aggactaagg agcgcctgag
    31621 cttttaacag ctcgaggcgc tcttggtatg attttttaga aaatccattc caacttatct
    31681 tcattatttt tcaaccttgc tataacggcg ttggtggtcg agaatttcaa ccaaggcaaa
    31741 atcttgattt tcatagccag caaactgggc agagtttgtt tcatccaagt ttacttcctc
    31801 aaaaaagacc ttttcatagt ctgcaacgga tagggcagtt cgttggttga gcttgttcaa
    31861 gcggtcttta tccaaataag cttcatatcc ttcaaccaat tcaccactga agaactcagc
    31921 cacagctcca cttccgtaac tataaagggc gattttatcc ccagctttca agctatctgt
    31981 attttccaag agagacaaaa gtccaaggaa aagtgaacct gtgtagatat tccccacctt
    32041 ttgactgtag agaatagact ggtcaaaatg cttttgtaag aggtcttttt tctcttgagg
    32101 caggctctta tccatgattt ttttcaagcc ttttagcgct aatttaggat aaggcaagtg
    32161 gaaacaaaca gccgcaaaat catccaaagt aagctggtag cgtttttgat attcaagcca
    32221 agtcgttttc aaactatcca agtattgttg ggtagaatag acaccattta cataaggagt
    32281 tgtcgagtaa tttggtcgcc agaaatccat gatgtcacgg gtctgagcta cattgtcatt
    32341 attaaaggcc atcatgcgtg gattttgtgt aatcaacata gctacacttc cagcaccttg
    32401 agttggttct cctggagttt caataccgta tttggcaata tcactggcaa tgaccaagac
    32461 cttggactcc ggagaatttt ccacatgcaa tttggcataa tggagggcag cagtcgctcc
    32521 gtagcaggct tctttaatct cgaaactacg agcaaagggc tggatgccca gcaagccatg
    32581 cacaaagacg gccgcagcct tactctggtc aattcctgac tcggtcgcca caatgaccat
    32641 gtcaacttct tgtctttctt gctcagttaa aatagagtca ctagcactgg ccgccaaggt
    32701 cacgatatcc tcagttaggg gcgcaatact caattccttg agtaagagtc ctttacttaa
    32761 tttttcaggg tcaattcccc tcgcttctgc taagtcttgt aatttcaaga catattgact
    32821 ggtcgcaaaa ccaatcttat caataccgat tgtcatattt acctctgttt tatcattcat
    32881 gtaaaaaatc gttctatact attttatcac aaatggcagt aaaagagaga aaaaagactt
    32941 gattcaccaa atcaagcctc ttattggtca tcattttaaa gaatgattag ttgctagaga
    33001 gttcaccgat ataagtagct ttataagctc cattcacagt tatcagctcc tggaggatca
    33061 aatttcctga gtaagtcctt cccatctcat ctacaaattt ttgataaaac tgactggtcg
    33121 gaatttctct gacatcctta tcaaatgtct tatcaagtgt tttactaacc ttctcagcaa
    33181 tcaattgatg ctcttgccat ccactttgaa actctgagcc cgaactagaa accatgactg
    33241 ggataaacaa caaggtcagt agacttacag acaataagga aaatagtaga cttcctgcaa
    33301 aactagaatc ctagttcatg attgataata acagcaatca aattcattcg taatccgaag
    33361 cgtttacgat gatttcgata ggttgttgaa aacattttaa acgtttttac tttggcaaag
    33421 atgttctcaa ccttgcttct ctccttagat agcgcatggt tataagcttt atcttcagct
    33481 attaacggct tgaggttgct ggatttacgt ggagtttgtg cttgaggata tatcttcatg
    33541 ggcccttgat aaccactgtc agccaagatt ttaccagctt gtccgatatt tctgcgactc
    33601 attttgaaca acttcatatc atggcaatag aaacaattct cccttgactt gtgacaatcg
    33661 cttgagcctt catagcgtgg catttttttt accagaatca ttcgctaatt ctttttttag
    33721 ggcgattgat ttgtacttcc gtcgcatcaa tcattaccgt gtcctcagaa ctgagaggag
    33781 ttcttgaaat cgtaacacca ctttgaacaa gagttacttc aacccattgg ctccgacgga
    33841 ttaagttgct ttcgtggata ccaaaatcag ccgcaatttc ttcataagtg cggtattctc
    33901 gcacatatag aaagcgttgt taatttattt atctcatttt tcagaaaatt cttttatttc
    33961 tgtaaagtct acgatactcg atgtgtcttt atataattat acagtctgag aatcactgtt
    34021 ccgctagcca ttccaataga gattaccaga gccaacatga caaccaaggt cgcacttgcc
    34081 agtgctttat tatagtcccc tgtcacaaaa aaggcagttg ttcggtagga gagataacct
    34141 ggaaccagcg gtgccaaaat ggccaagata aagaccacag caggtgtctt ataaagaata
    34201 cttaaaatct ggctgacaca agaaccaata atggctgcaa tgaaggtagc tacaatgaca
    34261 ttggtcggtt ccttgagcaa gagatagatt agccagacag tcatgcccaa aatccctcca
    34321 ggtaagagca tagaccgttg cacattgagt acgattaaaa aagtgataat ggcaagaaaa
    34381 cttgctactg cttgtaataa aaaggttgtt agtgtcatat tagttcatca ataccaaggc
    34441 gacagaagtt cctgccccta aagcgagggt aatgagcagg gattcaaaca tcttactcat
    34501 accagagttt atgtggttgg tcataatatc acggaccgca ttggtcaagg caatacctgg
    34561 tacaaacggc atgaccgcac cagctataat caaatctgcc gttgaaggaa aacctgtgta
    34621 gcgagcccaa aactgggcaa ttatcccaaa gacaaaggct ccagcaaagg ctgtcacaaa
    34681 gggaattcgg ataaattttt ccacatagag ggaaaaggca aaaccaaata aggtcgccac
    34741 tcctgcccca agtgcgtcgt agatatttcc gctaaacata actgaaaaga aaggagcact
    34801 aaaggtcgca gccagagtta cctgcaactt agtataggga aggggttgag cttgcaaggc
    34861 cgtcaattgc ttaaaggctg tttctaagtc aatctgcccc ccaactagct gacgagaaat
    34921 ctggttcaca tcgcagactt tttcgatgtt ataagaagag gaggtcacgc gcttcatgcg
    34981 cgaaatattg gtattttcaa tagagaaaaa gatagcggca ggcatggcaa ggacattgca
    35041 atccacaatc ccctgcgaat gcgcgattcg aatcatggta tcttctacac gatggatttc
    35101 tgagccactt ttaaggagaa tagtccccgc tagcataatc acatcaatga cggcatttaa
    35161 ttcttttgat tcttccatgc tttcctcctt ttatcaactc cctctattct atcacaaatc
    35221 tggactcaaa aaaaatcttt gccatgaaat catgacaaag attgattact cattttgatt
    35281 atccatctac ttttaaggag tagctgaagt tgttttaggt ttgtagattg aaatcttgac
    35341 tctagtctta ttgaggtcta ccttttcacc tgctctagga ctttgttcaa caaccatgcc
    35401 ttctgcacta cctgcaggcg ctgtcgtcac ttctacaact tctatattag cttccttaat
    35461 cccaacaatt tgaatcaaat tgttcttagt aaactccaag ctggaaccaa tgtaactcgg
    35521 catggcaaca cttgtaactt ttttagctac tgtcaagaca atttgagtag gtttactcac
    35581 atcataagtc gttccggcac ctggactttg tttcataatc gttcctggtt cgctttcgct
    35641 ggactcttct tcctctatct taatcaaatt ctcaggaacc ttcttctgct tgagttctga
    35701 gattacttct gtagagttcc gtccaatata gttccctaat tgaatcgtcg tagctttttt
    35761 agctactgtc aaaataattt gagttgcctt gctcaagtca taggtcgtac cttctggtag
    35821 actttgcttc aggaccgttc cagcctcact ctcattcgac tcttcttcct caattttaat
    35881 caaattatct ggaacttttt tctcttttaa ttccgcgata acatcagaag atttccggcc
    35941 gacataatta ctaatttgga aggattgttt gcctgatgag acaaccagat tgattttcgt
    36001 tccttctttt cgaccagttc cagcgccagg atctgtacgg ataatccgcc cttcttccac
    36061 cttttcacta gcctctgtct tctcctcacc aatctcaaaa ttggcttttt tgagcgttgc
    36121 cttggcctct gcaactgtct gacctgccac atctggaatg gcaatggttg caggagttct
    36181 ggatagtatc caaataagag aagctgccac caatacaagg ctggccaaca aaatcaggta
    36241 acgcatctta aatctatgtt ttttcggtgc ttgtggttgg taagtttcct ctgtcacagc
    36301 ctggcttggg tttttgattg atttgtgttc tgtctgcgct tgaaccttag gaatagatgt
    36361 caaggtactc tgagaaacct tcggcaaggt cttggtatct gccttgctcg tttcatcaaa
    36421 gattaactta ctttcatttc tacgattgta ggacaagcta ctagacaagt ccacatacat
    36481 ctctgaaacc gagcggtagc gattggtcaa ctttttagca gttgccttga taataacatt
    36541 ttctaaagcc tgaggtacag atggattttc tgcaataacg gacggcaggg gtttctggaa
    36601 atgctggagg gcaatggtca ccgcgctatc cccgtcataa gggatatggc ctgtcaacat
    36661 ctcatagaaa ataatcccca tggcatagat atcactctgc acagtcgcct tagaaccacg
    36721 cgcctgctct ggtgacaagt aatgaactga gcccaacatc gagttagtct gggtcagact
    36781 tgtctctgca aaggctacag caatcccaaa gtctgtgacc ttggcagtcc catctggtgt
    36841 caaaaggata ttttgaggtt tcaagtccct gtgaacaatt cctcgagtat gggccaagcg
    36901 catagccaag agaatttgtc ccatgatacg gactgcttct tcattagaaa gaggataatg
    36961 ttccttgata tagcgtttga ggtccagtcc agccacatac tccatagcta ggtactgttg
    37021 accgtcttcc tcgccaatat ctgttatccg aacgatatga ggatggtcta gatctgccat
    37081 agctctcgct tcacgctgaa aacgagctac agctatcggg tccgtctggt agttggtcct
    37141 cagaaccttc actgccactt cttccccatc taagattaag tctttggcta ggtagacatc
    37201 cgccatgcct cctcgaccaa tctgtttgac aatccgatag cgtccggcaa aaatcttgcc
    37261 gatttggatc attctgcatc ctcctcgttc atagaaacaa gggcaaccgt aatgttgtct
    37321 aaacctcctg cattgttagc aaaacgaaca agtgtctccg ttttatctgc taaaggaata
    37381 tcactggtta caatatcacg aatctcactg cctgaaatca tgttggtcaa gccgtcacta
    37441 ttgagcaaga gatagtcacc tgactcaagg ataactgtcc caaaatcagg ctgaatttca
    37501 tctttttgcc caatagactg ggtgataata tttttttgcg gatgagcttc tgcctcttct
    37561 ggtgtcaatt gaccagcctt gagcaattca ttaaccaagg aatgatcgct cgtcaactga
    37621 tggtattctt ctccacgaat caagccgata cgcgaatcac caatatgagc atagatagcc
    37681 tgattatcaa taatagcaag gacttccaaa gtagttccca tgcctctgta agcttcatcc
    37741 tgaccaagct ggtgaatctt ttgattttca atttctaggt aatgggcgaa ccattcacgc
    37801 acttcattga ctgtatcgat ctgagtatca acccaagcta cacccaggtc tgtgactgcc
    37861 atttcactag cgatattccc tgcgcgatga cctcccatcc catcagctaa aataatcatg
    37921 gtacgtccag ctctattgac atagtggttg acatagtctt ggttatttgt tcgtttctga
    37981 ccaacatctg ttaataatga aatttccatg tgtcagttcc ttcctaatcc gatatcttgc
    38041 gaaattgact gatgaagaat ccatcacttc catacaattc aggtgtaatg aggatacagc
    38101 cgtctttcat gatatcctta cattcatgtt ctagttttac ctgctcgaac tcgggatgac
    38161 tctctaaaaa ggccttaacg acttgaaaat tctcctctga gacgatagtg caggtgctat
    38221 aagttattat accacctttg cctagtattt gacaaacact acctaatatt tctaactgaa
    38281 tttcctgcaa ggacgcgaaa tctgccgttt ctttattgta tttgatatct ggttttcggc
    38341 gcaaaagacc gattcctgaa caaggagcat ccaccaaaat cttatcaaag gaatcctggt
    38401 caaaaaactc atgcaccttt ctggcatcca atttttgagt ttgaacccga tcttcaactc
    38461 ccagacgttg ggcattttct tgaattaaat ccaacttatg gtcgtacaag tccagagcag
    38521 taacctgacc tgtcgtaaga taagaggcta tatgggctgt tttcccacct ggagccgcac
    38581 aggcatcaag cactcgctca tcaccttgta aatcaagcgt cggagcaacc agctgactgg
    38641 actcatcttg gatggtaatg gctccattcg caaacaaatt atgccctgca aaatgcccct
    38701 gctccttaac cagaccagtg gttgctaaaa gggaattatt cgcctccaac aaggcttgga
    38761 tttcctcttt tcgacttagg tctgttacac gaatactggc tttgtttcgc actaacaggc
    38821 tttcaaagat ggcttttgct ctctcctctc cgtattcttc cttgagtttg gcaactagcc
    38881 aaactgggag agaataggca atggagtcac gcttgttttt tcgcttgatg ctagcaatat
    38941 ctggccagcc ttcacgcaag atacggcgaa ggacagcgtt gaccaatttt tcactgcctt
    39001 ttttacggag tttggccaat tccactgctt cattgaccac agcatgatct ggaatcttgt
    39061 ccaaatagcg gagttggtag gcactcatga gaagaaggac atagagccag ctgtctaact
    39121 ggtctctgtc ttcgataaag tgggataggt accattccag agtcagttta cgggctaccg
    39181 ttccatagac tagctcggtc actaagccct tgtctgctgc agagagctga ctccccttga
    39241 ggtgtttatt taaggcaata tttgaatatg cttgattcac aaaaacatcc tctagcactg
    39301 ctagagctaa acttctagcc gtttctactt tagtcaccaa atcgttctcc tacagtcaat
    39361 gtacgtccaa ctccgttgag gaaggaagca atgtccatct taggcttacc agctggctgc
    39421 acttgtttga gggatagagc cccttcagcc gttgcgacaa tcaattcttt cttgcagata
    39481 gagagaatct cacctggatt tccctgacct tctactggta gggcttcata aatcttaaag
    39541 cggtcgccct taaggaaagt atgggcaaca ggccaggggt tcattccacg aatttggtta
    39601 aagagttgac gattggtttt gttccagtcc agtttttctt cctctggctt tatatttgga
    39661 gagaaggtaa cctgactcgt atcctgcggt tcaggtttga tatcaccagc aatataggca
    39721 ggcagagtgt ccaaaagcaa atcacgacca actagcgcca atttttcaaa caaggtgcca
    39781 acattgtcct catctgtgat cggaatgctg cgacgagaaa tcatatctcc tgcatccatt
    39841 tccttaacca tttccatgat ggtcacacca gcttcctcat ccccttgaat caaggcataa
    39901 tggataggcg caccaccacg gtgtctagga aggagggagg catgaacgtt gacagcaaag
    39961 tccatgctat caaggagttt gcttgggaga aactgcccaa aagcagcagt cacaattcca
    40021 tctgctccta gcttcataag ttcttccatc tctggacttc cagataattt ttcaggttgg
    40081 tagatagata gtcctgcttc cttggcagcc tgcttgactg gggtttcttg gataactttt
    40141 ttacgaccaa cagcacggtc tggctgggtc acaacggcta gaatttcgta acggtcatct
    40201 gtcaaaagtc cttttaagac tgttgctgaa aagtcggggg tccccataaa gattagtttt
    40261 gtcatatctt ctccttctta taaaaattgc tgcggctcat ggtcaatgct gagacggagc
    40321 tcactatttt cccgttcttg agtcaaggct aaaacctggt tgagggtcgg ccccagctca
    40381 tcttctaaac ggtatttaat taaaatctgg taatgataga ggttgtgggt acgggcaatc
    40441 ggttttggcg ttggccccag aatgggactg gtctctgaca agcctgaccg caaaatgttc
    40501 atgacttcat aggcacgttt gaaaacctct tcttctttct tgtgagaaag ggtaatacca
    40561 atcgtgaaat agtaaggtgg atagccgagt tgtcgtctga ttcccatttc ataggcataa
    40621 aagccttcgt aatcttgatc cttggcaaat cgaatagcat agtgctgcgg attgtaggac
    40681 tgtatcaaga cttgacctgc cttttcagcc cgacctgctc gacctgccac ctgagtcaag
    40741 agctggaagg ttctctcaga agaacggaaa tcaggcagat tcaaggccgt atccgcattt
    40801 agaactccga ctagggtaac attgggaaaa tccaaaccct ttgcaatcat ctgagtacca
    40861 agtaaaatat ccgcttcccc tcgcccaaac tggtcaagca aggcttggtg actgcctttc
    40921 tttcgagtcg tatccacatc catcctcaga atgcgagctt ggggaaagag ttctgctagc
    40981 tcatcataaa ccttctgagt tcccgtccca tagtaacgaa tactgtggct cttacagtta
    41041 ggacagacct gaggaatatc cttcgagaaa ccacaataat ggcagttcat agtcttggta
    41101 tccatatgca aggtcagaga aatatcgcag ttgggacaag tatccaccgt cccacactcc
    41161 cgacacatga caaagctaga ataaccacgg cgattgagca tgagaaccac ctgctctttt
    41221 ttaaccagac ggtcttggat agcctctagc aaaggaggcg taaagtttga cgtctcattt
    41281 tgtccgatat agtctcgaaa gtcaatcact tgaacctcag ggattgtagc caaaggattg
    41341 gcacgttggg ttagacgtaa gtgttgatag acgcctttgc cagcacgcgc ccggctctct
    41401 aagctcggcg ttgcagatcc aagtaccaga gttgcttgat tatactgagc ccgtaaaata
    41461 gctacctctc tggcatggta acggggattg ctttcctgct tataagccgc ttcatgctct
    41521 tcatcaataa tcatgacacc cagatttttc agaggagcaa agatagcaga tctggcacca
    41581 acaacaactt gggcatcgcc acgctccacc ttgcgccatt catcatactt ttcaccattg
    41641 gataatcctg agtgaagaat ggctaccttg tccccaaagc gtgctataaa acgctcggtc
    41701 atttgaggag tcaaggaaat ctcaggtacc agcaaaatag ctgtcttgcc cttatccagg
    41761 gcaccttgga taatctgcaa gtaaacctcg gtcttcccac ttcctgtaat cccttgaagt
    41821 agaaagggag gttgagaact gccaatagaa ctcacaaccg catcacgcgc ctgtctttgt
    41881 tctggattta actccaaagg tctacttgct tcaattcctt caaaataagc agccgagcgt
    41941 tgaacttcct tttggactat ggtaacagca ccttgatcca caaagaagtt gacttgctct
    42001 cgcgagtagg actccaacaa gctagccaag gaagcgctct ctggatgaga cagcagataa
    42061 tctctcagtt ccaacttttt cttggcacgt gtagaaatct caacaccttc taattgagca
    42121 tggtcaacct cataccaaga ctgggtcttg accttctttt gatcgactgc ctgatattcc
    42181 agaccaagca ggccttttct agtcaaacgc atcatttcag cttgcttacc taaatccaga
    42241 gaagaaaagg ctagcgaatc ttctgaacca aacaggcgta ctcgttcttc ctgactcaag
    42301 ccttccagag gatagagaat cttgtcatag ctagaattca gaaatcccgg aagcatggcc
    42361 ttgaggatag agattttgta ggagaagaca gatttgcgta actcctcagc cagccagagt
    42421 tgttctggcg tgagaacagg agaaaaatcc agcacctctg caatatcttt taaatcttgc
    42481 tccatctctt ctccatctga ttgggactcc aaaccaagaa caatcccttg aatcaggcga
    42541 ttacccttac caaaaggcac atgaacccgc atcccaactt ccagcattcc ctcaaattcc
    42601 tccggaatcc tgtaactata gggctggtcc gtctgcatca agggcacatc tacgataatc
    42661 ttagctaggg ccatcttctc acctcctcct tgtcagtaca ttcttgcaat agaaaaaata
    42721 agattgagtc cccccaacct taaatttttt caccatcttc tttttcttta gcaatttgct
    42781 ctttgatttt cttttcttct tcttctttgc ggcgtttttc ttcttcgata cggcgacgca
    42841 ctgcttcacg ttttccttct ggatctgggt gaattgtaac gtttcctgat tcgatttctt
    42901 ctaaagcgcg aagagttgat ttttcagact tgaaaccttg agttgctggg gcacctgctt
    42961 ccaattcgtg ggcacgtttt gcttccaaga ttacgagtga atattttgaa ggaaccttgt
    43021 cgagcaaggt atcaatagag ggttttaaca tcatttgctt gtacctattt tctaaatttt
    43081 atcgggtagt tggagatttt ggtaacatct cctgatagtg accaatgaca cgatccacac
    43141 agaagtgttc tgcttcaatc acacatttga cacgttcagc agctaggggc acctgatcgt
    43201 tgacaatcgc ataatcatac tcacgcatga gggcaatttc ttccttggcc ttttcgattc
    43261 gttgggcaat cacttctgca ctatctgttc cacgacctac caagcgatct tgcaattcat
    43321 ccaaatctgg tggtgtcagg aagataaaga cagcatctgg aacctttttc ttgacctgaa
    43381 gagcaccctg aacttcaatt tcaaggaaaa catcgattcc cttgtccaag gtttcattga
    43441 cataggtcag aggagttcca tagtagttgc cgacatattc tgcgtattcc aacatctgtc
    43501 cttgacgaat cagctcttca aattcttcac gagtacggaa gaaatagtca acaccgtcca
    43561 cttctccagg acgttgtgcg cgtgtcgtca tcgatacaga gtattgaaat tggttttcag
    43621 aactctcaaa aatctctctt ctaaccgttc cttttccaac ccctgaagga ccagaaaaaa
    43681 cgattagtaa gcctcggtct gccattgtgt ctccttttag tcaatctgtg aaataacatt
    43741 tctctagaat aatggcaaaa agccagatta tcctttacag tctttctatc tagtgtaaca
    43801 aaaaagcagt aatttttcaa ctgctctttc ttatttattt agcataatct actgcacgaa
    43861 gctcgcgaat cacggttacc ttgatatttc ctggataatc gagattgttt tcaattttct
    43921 tacgaacttt gtgagccaag attgtgactt tgtcgtcctt gatttttcct ggattgacca
    43981 tgatacgaat ttcacgtcct gcttgaaggg caaagctagt ttgcactcct tcaaagccgt
    44041 tagcaatttc ttccaaatca tggagacgct tgatgtagct ttcaagagac tcactacgag
    44101 cacctggacg ggctgcgctc aaggcatctg ctgcagcgac gataactgct atcacgctct
    44161 cagcttcaac atctccgtgg tgactagcaa tcgtattcac cacaactggg ggttccttgt
    44221 acttacgggc caattccata ccgatttcaa cgtggctacc ttcaacctca tggtcaatgg
    44281 ctttcccgat atcgtgaagg aatccagcac gacgggcaag agccgcattt tcaccaagtt
    44341 cgctcgccat gataccagcc aacttagcaa cctcaatcga atggcgcaaa acattttgtc
    44401 catatgaagt acggaactgc aaacgtccca taatcttcat caagtctgga tgaaggtttg
    44461 gcgcaccaat ttcataggca gcagcctcac cgtattcacg aatcttattg tcaatctctt
    44521 gacggttttt ctcaaccaac tcttcgatac gagctggatg tatacgacca tctttgagca
    44581 acatttccat agtcatacgg gcaatctcac gacgaatcgg atcaaatcct gacaaggtca
    44641 ccacttctgg tgtatcgtcg ataatcacat cgacccctgt caaactttca aaggtacgaa
    44701 tgttacgacc ttcacgacca ataatgcgtc ccttcatagt atcgtctggc agatgaactg
    44761 ttgagtttgt tgactccgct acatattcac cagcgatacg ttgcatagct tgaaccaaga
    44821 tgtccttggc cattttgtca gaacgttcct tgacctcttg ctcagcttcg cgaatgcgac
    44881 tggcaatctc cctggtcaag ttttcctctg tctgagccaa gataatatct cgtgcttctg
    44941 cctgagacag agcaccaata cgctctagtt ctgcttcttt ttgtctttcg acttcctcta
    45001 attgctcttc acgcgcatca aggtttttcg ctctatcaga aatactttgt tctttttgtt
    45061 caagtgtttg ttctttactc gtcaaattgt cgtccttacg gtcaaggcta gtagctctct
    45121 ctgtcaaacg actttcgatt tgtttgagtt cttgacgttc tgatttaaat tcagcgtcca
    45181 cttcttcacg gtattttctg gcttcttctt tggcctccaa tagtgcttct tttttaagag
    45241 acttgctttc acgtttggct tcattaacaa gtaaatccgc ttcacgctca gcttgtccac
    45301 gtaaattagt tgcttcttgt tcagcattta aaagcatcaa ctctgcagct tcatgagatg
    45361 atttcatctt agctgagatg ctgacatatc caatgactaa accaatgatg acggcaaaaa
    45421 cagcaatcgc aagcgacatg atctccatgt ttttacctca ttttattgtt attccgaatg
    45481 acatacattc ttttacattc taccataaaa aagtgatttt cacaaaccta aaatagaata
    45541 tgttttgggg aatttggaac acatttgcca aaataaactt gttttttaga aatagtagtt
    45601 tagtagagac ttgagaaaaa gcctaccttt caatagactt agtaatgatc tttaaaggac
    45661 aagaaagcca cgctatctcc atccatcata taaatcaagc gattttctgc atcaatacgc
    45721 cgtgaccagg ctccttggta atcatatttg agtggctctg gttttcctat tcctgtaaat
    45781 ggatcgcgtt gaatatcctt gattaattta ttgattcttt ttagtgtttt tttatcttgg
    45841 ttttgccagt agcaataatc tgcccacgca tcttctgtaa acttgagtag cattcatcac
    45901 tcctcaatca catggacctg agtgcttcca gcacggactt gagccattcc tcgcaaaacc
    45961 ttgtctgata actccttatt ttgggcgatt ctcagggttt cctgaatact gtcccattcg
    46021 ctctttgaaa gaactacaat gtcctcatct ggatttttat tgaccaccgt caaaggctca
    46081 aattcatcat ttaccttctt catgtagtcc tttaaatgat ttcggaatgt tgagtaaagg
    46141 actgcttcca taaccatacc tcgttttagc tcttttccac tattatacac gaaaagaaag
    46201 aaattgtcag gaacttgtac aagattttct tttctatcta tttatactca atgaaaatca
    46261 aagagcaaac taggaaacta gccgcaggct gtacttgagt acggcaaggc gacgttgacg
    46321 cgatttgaat ttgattttcg aagagtatta ttcgtaaaaa atctcaaaaa gcctaccttt
    46381 cggtagactt agcttgtttc tattctaatc ggcactcttc caaaattttg ctctgctata
    46441 cttggctttc ctagttggta aatctggtct gctttttggg tcatagcatc ccaaggttct
    46501 ttgccaattc ggctgactag attgacctgt cctttcagag acttgagatg ttgcctgcct
    46561 ttttcagtaa atccaaggac atgaatggct tctggcaaga cattttctct agcctgcacc
    46621 aaaatatagg tcaataggcg tctgacacgc gccttggtgt aacgtttggt cgcaaccgcc
    46681 tcgaccaact cttctacaga ctgggctgtt ttaatagctt ctttaatgcg cacagccatt
    46741 tcttgattga cctgatagat ggtggttagg tcgggatttg acaagatttg atagcggagc
    46801 aagggaaaat agtcttccca gatcacctta ctggcctgct caaatagggc aacagaaggc
    46861 ataaagcgtt ctaagaaatc ttggtccttc tgatgttgac ggagggctgt cgccgaggca
    46921 aagtccacat ctttattcac agaatggtaa cctgccccct gacgctgaat cggatgcagc
    46981 ttgatatttc gtcctgcaac tgccttggca taggccagag caagaacatg attgggggta
    47041 ttacctgaaa aatcaagacc agcaaattcc ttccacatag cttgggtttt ctggggatag
    47101 gaaagggaat caggcagatt ttccacaaat ttctccatct cagcaccttt ctctgtgtat
    47161 aagtcagcga ttttttgata atctagaact tcttctgtcc caaaagcgag gctatctatg
    47221 cccaaccgag ctaagatatc cacggcccct tgaccgaaaa aatctgccgc ctgaacgctg
    47281 actaaaaagg gcaattccac taccagatcc gctccatttt ccagcgccat ctgggctcgt
    47341 gtccacttat ccacgatagc aggttctcca cgctgcatga aattccctga catagccacg
    47401 attttcagcc cctccgcttg atccagcagg tatttgtgtc cattatgaaa aggattgaac
    47461 tccgcgataa tacccgtgat ggtcatagta atctcctact tctttagtat caaattgagt
    47521 caattatatt ctgtaggctc cgtttttgag tagttgtttc ctcaatgaat ttaattgacc
    47581 attcttttaa gtaattgtgt ctactaaaat accagccatt tatccactta tttattaaag
    47641 ttttttcatc atcgttcaac atgttataat attttctttc atttatcttc caatttgata
    47701 ctatatcaga ctctaatttt tctatatttt cataatcact tattgataat atatcaatac
    47761 ctagattagc aaatattaaa aattgcaagc taaaataaaa gtgaacttcc tttgttagta
    47821 aaaagtgcaa ttctaatttg ttttctctac tatcttttct acagataaag taattgaaac
    47881 acgtaacaat tttctctgtg atatccccca ttctgctata cttttcatcc attctttcta
    47941 tgattggaat acataaattt ttgtaagtcc tttctttctg tattttaaaa agtgcattca
    48001 taaaagtttt atgtgctaca atattattcc tatctgcttc agaccactta attagtatct
    48061 gtttttggag tttatcatct agctgattaa cacctactgc agcaaagtat tcttggaatg
    48121 aacggtgaga gaattttaaa ctaacgcctt cttgaagcat catacaagca ctatgagtcg
    48181 catcataaac tatatcattc gtctttaatt caaggttatt tttaaaacaa tatttagtaa
    48241 ttatttcatc aagtgtagtt ctatcgaaat ctacttttcc ttcaaagaat gtttttaaac
    48301 caatgtaggc taatatattt cgaaattctt caggagttaa ttttgctttt agttctcttt
    48361 tgtatcctga tttagatgca tcatgtcttt ggtacaatgt ataaaaggcc tgattataaa
    48421 aatcagttaa attatttgga atagaagcac cagcttcgta agtcattaac ataattgtta
    48481 ataggagtgg gatagaagca aaagattcat gagtatcata taaatgatcc tttaattctc
    48541 tgtagaaacg cctttttact ttctcatcat aattcaactt atcaattaag gataacgctt
    48601 gctctctatt taattttttt atctcatact cagcaaactg attccaacca ataaattcct
    48661 cagacggtct tgacgacaaa acatatctat tgctattgta taacgttaca aattctttaa
    48721 tttctttgtc caaccaagaa cgttttgaag gattaacctc atctaaacca tcaaaaatta
    48781 ttgtatatct tccagcctct aatgtcgctt taaaatattt cttttctaaa tttaaatgat
    48841 gattttgaac ctcttggtaa ataaaatcaa ctaattcatt ttctgagaaa tcagattcat
    48901 taagtgattt taattcaata aaaattggaa ttgatgtagc ttgttgtact tgattgataa
    48961 aaatatgctt tacaagcatt gatttaccaa tcccacccgt tcctgtcaaa ataacgttag
    49021 atgttttttc aaaaatcaat tctgtg
//
LOCUS       DAVLHC010000011        48418 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.011, whole genome shotgun sequence.
ACCESSION   DAVLHC010000011 DAVLHC010000000
VERSION     DAVLHC010000011.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 48418)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 48418)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..48418
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.011"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            1..769
                     /locus_tag="VXE25_000661"
                     /pseudo
     CDS             1..769
                     /locus_tag="VXE25_000661"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="frameshifted; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=2
                     /transl_table=11
                     /product="IS3 family transposase"
     gene            complement(885..1688)
                     /locus_tag="VXE25_000662"
     CDS             complement(885..1688)
                     /locus_tag="VXE25_000662"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fic/DOC family protein"
                     /protein_id="HEV0771170.1"
                     /translation="MQSTYNIDNPNLSYEAKRDLWRIGFGLQKVDNLVPSAYMESLAE
                     KQSRGELTYEQVYENATAYHHTIDASTEEADLVSLRIVELLSRRGFSFSPATLLAIHK
                     ELFQDIFEPSIPVGQFRQTNITKNEPVLNGESVVYSDYSMIQMTLDYDFNQEKQVAYA
                     TLTQADVVKQIQHFISGIWQIHPFREGNTRTVTVFLIQYLREFGFDIDNTPFQQHSKY
                     FRDALVLDNAKILQRRSEFLTAFFENLLLGGQNDLSSEKMYLDLDLDFS"
     gene            complement(1965..2720)
                     /locus_tag="VXE25_000663"
     CDS             complement(1965..2720)
                     /locus_tag="VXE25_000663"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000033780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3883 domain-containing protein"
                     /protein_id="HEV0771171.1"
                     /translation="MSKHPHYELLNLIGYGLAKFDKLFIKEFQCSSKSEFYRYVVSLG
                     IAETTGVVKNRMDLFDPYFDNNRKGWWQKAEVYRFRKDLIDMMFGNEDVHSYAEIVKM
                     LLASEGKKTGITIVEKPIVRTKFKRLQETGMEAENYFILHFDKEEKFQGGQLTDARLY
                     GDGYDFQVDVQEYSYLAEVKGIRKSKGRVRLTAKEFEKVKEFQSDFILSLVTNLDDIP
                     KLVLIDNPLKHFEFKKNIIKNEIIEYRSVEDLY"
     gene            complement(2790..5441)
                     /locus_tag="VXE25_000664"
     CDS             complement(2790..5441)
                     /locus_tag="VXE25_000664"
                     /EC_number="6.1.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009732359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="valine--tRNA ligase"
                     /protein_id="HEV0771172.1"
                     /translation="MSKELSSKYNPAEVEAGRYQKWLDADVFKPSGDQKAKPYSIVIP
                     PPNVTGKLHLGHAWDTTLQDIIIRQKRMQGFDTLWLPGMDHAGIATQAKVEERLRGEG
                     ISRYDLGRESFLTKVWEWKDEYATTIKEQWGKMGLSVDYSRERFTLDEGLSKAVRKVF
                     VDLYKKGWIYRGEFIINWDPAARTALSDIEVIHKDVEGAFYHMNYMLEDGSRALEVAT
                     TRPETMFGDVAVAVNPEDPRYKDLIGKNVILPIANKLIPIVGDEHADPEFGTGVVKIT
                     PAHDPNDFLVGQRHNLPQVNVMNDDGTMNELAFEFSGMDRFEARKAVVAKLEEIGALV
                     KIEKRVHSVGHSERTGVVVEPRLSTQWFVKMDQLAKNAIANQDTEDKVEFYPPRFNDT
                     FLQWMENVHDWVISRQLWWGHQIPAWYNEAGEIYVGEEAPAGDGWKQDEDVLDTWFSS
                     ALWPFSTMGWPNTETTDFKRYYPNSTLVTGYDIIPFWVSRMIFQGIEFTGKSPFKNAL
                     IHGLIRDEEGRKMSKSLGNGIDPMDVIDKYGTDSLRWFLSNGSAPGQDARFSYEKMDA
                     SWNFINKIWNISRYILMNNEGLTLDVAHDNVTKVATGEAGNVTDRWILHNLNETIAKV
                     TENFDKFEFGVAGHILYNFIWEEFANWYVELTKEVLYSDNEEEKVITRSVLLYTLDKI
                     LRLLHPIMPFVTEEIFGQISEGSIVTAEYPTINPAFEDLAAHTGVESLKDLIRAVRNA
                     RAEVNVAPSKPITILVKTSDSDLEAFFNSNVNYIKRFTNPEHLEIASTIPAPELAMSS
                     VITGAEIFLPLVDLLNVEEELARLEKELAKWQKELDMVGKKLSNERFVANAKPEVVQK
                     ERDKQADYQAKYDATVARIDEMKKLVK"
     gene            complement(5434..6012)
                     /locus_tag="VXE25_000665"
     CDS             complement(5434..6012)
                     /locus_tag="VXE25_000665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000550018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HEV0771173.1"
                     /translation="MHLFIIGAPASGKMTIGQELSRLTDATLFYNHQAIDFALEIYQD
                     YTEEMWEFVRGITFSFLGASARNQRSVILTDVIDFSNQYHLIYLKQIQNLLDDYHQEI
                     LFVELETSLEECIRRNRTENRLKHKPLKRHIEVSEREILETAETLQLNSQYQPNELHH
                     YFKINNTNLSAEEAAKQIQNKINKIEKGHTHV"
     gene            complement(6012..6572)
                     /locus_tag="VXE25_000666"
     CDS             complement(6012..6572)
                     /locus_tag="VXE25_000666"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000124546.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0771174.1"
                     /translation="MARTELPDKIETERLVLRVRTVADAEDIFDYASLPEVAYPAGFP
                     PVKTLEDEIYYLEHILPERNQKENLPAGYGIVVKGTDKIVGSVDFNHRHEDDVLEIGY
                     TLHPDYWGRGYVPEAARALIDLAFKDLGLHKIELTCFGYNLQSKRVAEKLGFTLEARI
                     RDRKDVQGNRCDSLIYGLLKSEWEVI"
     gene            complement(6575..7138)
                     /locus_tag="VXE25_000667"
                     /pseudo
     CDS             complement(6575..7138)
                     /locus_tag="VXE25_000667"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809142.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="flavin reductase family protein"
     gene            complement(7422..7817)
                     /locus_tag="VXE25_000668"
     CDS             complement(7422..7817)
                     /locus_tag="VXE25_000668"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000038635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase"
                     /protein_id="HEV0771175.1"
                     /translation="MSKKLNRKKQLRNGLRRAGAFSSTVTKVVDETKKVVKRAEQSAS
                     AAGKAVSKKVEQAVEATKEQAQKVANSVEDFAANLGGLPLDRAKTFYDEGIKSASDFK
                     NWTEKELLALKGIGPATIKKLKENGIKFK"
     gene            complement(7913..8167)
                     /locus_tag="VXE25_000669"
     CDS             complement(7913..8167)
                     /locus_tag="VXE25_000669"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000119704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1912 family protein"
                     /protein_id="HEV0771176.1"
                     /translation="MSYEQEFMKEFEAWVNTQIMINDMAHKESQKVYEEDQDERAKDA
                     MIRYESRLDAYQFLLGKFENFKAGKGFHDLPEGLFGERNY"
     gene            complement(8177..9511)
                     /locus_tag="VXE25_000670"
     CDS             complement(8177..9511)
                     /locus_tag="VXE25_000670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000752887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF438 domain-containing protein"
                     /protein_id="HEV0771177.1"
                     /translation="MADERIHVLRDILLELHNGASPESVQERFDATFAGVSAIEISLM
                     EHELMNSDSGVTFEDVMELCDVHANLFKNAIKGVEVSDTEHPGHPVRVFKEENLALRA
                     ALIRIRRLLDTYELMEDEEMLAEMRKGLVRQMGLVGQFDIHYQRKEELFFPIMERYGH
                     DSPPKVMWGVDDQIRELFQTALTTAKSLPEVSISSVKEVFEAFAIEFESMIFKEESIL
                     LMILLESFTQDDWLQIAEESDAYGYAIIRPSEKWVPERQSFIEEKIAEEPVQLDTAEG
                     QVQQVIDTPEGHFTITFTPKEKEAVLDRHSQQAFGNGYLSVEQANLILNHLPMEITFV
                     NKEDIFQYYNDNTPADEMIFKRTPSQVGRNVELCHPPKYLDKVKAIMKGLREGTKDKY
                     EMWFKSESRGKFVHITYAAVHDENGEFQGVLEYVQDIQPYREIDTDYFRGLE"
     gene            complement(9511..9744)
                     /locus_tag="VXE25_000671"
     CDS             complement(9511..9744)
                     /locus_tag="VXE25_000671"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006144975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1858 domain-containing protein"
                     /protein_id="HEV0771178.1"
                     /translation="MDNIIDVSIPVAEVVDKHPEVLEILVELGFKPLANPLMRNTVGR
                     KVSLKQGSKLAGTPMDKIVRTLEANGYEVIGLD"
     gene            complement(10159..10341)
                     /locus_tag="VXE25_000672"
     CDS             complement(10159..10341)
                     /locus_tag="VXE25_000672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000522940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771179.1"
                     /translation="MGLIKTLAKIYGNYFLTVQGVKVMKTIKKDDHVVVGLGKLFIAD
                     KLMDTARWLIKPEERE"
     gene            complement(10343..11122)
                     /locus_tag="VXE25_000673"
     CDS             complement(10343..11122)
                     /locus_tag="VXE25_000673"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000840413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771180.1"
                     /translation="MAEQDLAMQVLQQVVKLPVVKVDRSKFLVDKFSKELGPQDIPTL
                     LEQGPTSLLSQEILDRVANACIRDNVLLASGTSVLAGLPGGLAMAITIPADVAQFYGF
                     SLKLAQELGYIYGYEDLWASRDELSEDAQNTLLLYLGVMLGVNGTAALLRAGGITIAK
                     QVMKTVPNKALTKTLWYLILKKVLRIFGVNLTKGGLAKGMGKFIPILGGIISGGLTFA
                     TMKPMGESLQKELSKLVNYSEVQYQEDVETIRKEAEIIEGE"
     gene            complement(11401..11751)
                     /gene="rbfA"
                     /locus_tag="VXE25_000674"
     CDS             complement(11401..11751)
                     /gene="rbfA"
                     /locus_tag="VXE25_000674"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001273594.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosome-binding factor RbfA"
                     /protein_id="HEV0771181.1"
                     /translation="MANHFRTDRVGMEIKREVNEILQKKVRDPRVQGVTITDVQMLGD
                     LSVAKVYYTILSNLASDNQKAQIGLEKATGTIKRELGRNLKLYKIPDLTFVKDESIEY
                     GNKIDEMLRNLDKN"
     gene            complement(12002..14794)
                     /gene="infB"
                     /locus_tag="VXE25_000675"
     CDS             complement(12002..14794)
                     /gene="infB"
                     /locus_tag="VXE25_000675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-2"
                     /protein_id="HEV0771182.1"
                     /translation="MSKKRLYEIAKELGKESKEVVARAKELGLDVKSHSSSVEEAVAA
                     KIAASFKPAAAPKVEAKPAAPKVSAEKKAEKSEPAKPAVAKEEAKPAEPVAPKTEKVA
                     AKPQSRNFKAEREARAKEQAERRKQNKGNNRDQQQNGNRQKNDGRNGGKQGQSNRDNR
                     RFNDQAKKQQGQQKRRNERRQQEDKRSNQAAPRIDFKARAAALKAEQNAEYARSSEER
                     FKQYQAAKEALAQANKRKEPEEIFEEAAKLAEQAQQVQAVVEVVPEKKEPAVDTRRKK
                     QARPDKNRDDYDHEEDGPRKQQKNRSSQNQVRNQKNSNWNNNKKNKKGNNKNNRNQTP
                     KPVTERKFHELPTEFEYTDGMTVAEIAKRIKREPAEIVKKLFMMGVMATQNQSLDGET
                     IELLMVDYGIEAKQKVEVDNADIERFFVEDGYLNEDELVERPPVVTIMGHVDHGKTTL
                     LDTLRNSRVATGEAGGITQHIGAYQIVENGKKITFLDTPGHAAFTSMRARGASVTDIT
                     ILVVAADDGVMPQTIEAINHSKAANVPIIVAINKIDKPGANPERVIGELAEHGVMSTA
                     WGGDSEFVEISAKFNQNIEELLETVLLVAEIQELKADPTVRAIGTVIEARLDKGKGAV
                     ATLLVQQGTLNVQDPIVVGNTFGRVRAMTNDLGRRVKVAGPSTPVSITGLNEAPMAGD
                     HFAVYEDEKSARAAGEERAKRALMKQRQATQRVSLENLFDTLKAGELKSVNVIIKADV
                     QGSVEALSASLQKIDVEGVKVTIVHSAVGAINESDVTLAEASNAFIVGFNVRPTPQAR
                     QQAEADDVEIRLHSIIYKVIEEMEEAMKGMLDPEFEEKVIGEAVIRETFKVSKVGTIG
                     GFMVINGKVARDSKVRVIRDGVVIYDGELASLKHYKDDVKEVTNGREGGLMIDGYNDI
                     KMDDVIEAYVMEEIKR"
     gene            complement(14811..15110)
                     /locus_tag="VXE25_000676"
     CDS             complement(14811..15110)
                     /locus_tag="VXE25_000676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlxQ-related RNA-binding protein"
                     /protein_id="HEV0771183.1"
                     /translation="MNKQKISNLLGLAQRAGRIISGEELVVKAIQDGKAKLVFLAHDA
                     GPNLTKKIQDKSHYYQVEIVTVFSTLELSIAVGKSRKVLAVTDAGFTKKMRSLME"
     gene            complement(15103..15396)
                     /locus_tag="VXE25_000677"
     CDS             complement(15103..15396)
                     /locus_tag="VXE25_000677"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000857559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlxR family protein"
                     /protein_id="HEV0771184.1"
                     /translation="MKTRKIPLRKSVVSNEVIDKRDLLRIVKNKEGQVFIDPTGKANG
                     RGAYIKLDNAEALEAKKKKVFNRSFSMEVEESFYDELIAYVDHKVKRRELGLE"
     gene            complement(15418..16554)
                     /gene="nusA"
                     /locus_tag="VXE25_000678"
     CDS             complement(15418..16554)
                     /gene="nusA"
                     /locus_tag="VXE25_000678"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination/antitermination
                     protein NusA"
                     /protein_id="HEV0771185.1"
                     /translation="MSKEMLEAFRILEEDKGIKKEDIIDAVVESLRSAYRRRYGQSDS
                     VAIDFNEKTGDFTVYTVREVVDEVFDSRLEISLKDALAINSAYELGDKIKFEEAPAEF
                     GRVAAQSAKQTIMEKMRKQTRAITYNTYKEHEQEIMSGTVERFDNRFIYVNLGSIEAQ
                     LSKQDQIPGEVFASHDRIEVYVYKVEDNPRGVNVFVSRSHPEMIKRLMEQEIPEVYDG
                     TVEIMSVAREAGDRTKVAVRSHNPNVDAIGTIVGRGGANIKKITSKFHPARYDAKNDR
                     MVPIEENIDVIEWVADPAEFIYNAIAPAEVDQVIFDENDSKRALVVVPDNKLSLAIGR
                     RGQNVRLAAHLTGYRIDIKSASEFEAMEDAASVELEVENDTVEE"
     gene            complement(16598..17077)
                     /gene="rimP"
                     /locus_tag="VXE25_000679"
     CDS             complement(16598..17077)
                     /gene="rimP"
                     /locus_tag="VXE25_000679"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000338698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome maturation factor RimP"
                     /protein_id="HEV0771186.1"
                     /translation="MDAIATIVELVREVVEPVIEAPFELVDIEYGKIGSDMILSIFVD
                     KPEGITLNDTADLTEMISPVLDTIKPDPFPEQYFLEITSPGLERPLKTKDAVAGAVGK
                     YIHVGLYQAIDKQKVFEGTLLAFEEDELTMEYMDKTRKKTVQIPYSLVSKARLAVKL"
     gene            complement(17203..17838)
                     /gene="trmB"
                     /locus_tag="VXE25_000680"
     CDS             complement(17203..17838)
                     /gene="trmB"
                     /locus_tag="VXE25_000680"
                     /EC_number="2.1.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001266107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanosine(46)-N7)-methyltransferase TrmB"
                     /protein_id="HEV0771187.1"
                     /translation="MRVRNRKGATELLEANPQYVVLNPLEAKAKWRDLFGNDNPIHVE
                     VGSGKGAFVSGMAKQNPDINYIGIDIQKSVLSYALDKVLEVGVPNIKLLWVDGSDLTD
                     YFEDGEIDRLYLNFSDPWPKKRHEKRRLTYKTFLDTFKRILPENGEIHFKTDNRGLFE
                     YSLVSFSQYGMKLNGVWLDLHASDFEGNVMTEYEQKFSNKGQVIYRVEAEF"
     gene            complement(17835..18629)
                     /locus_tag="VXE25_000681"
     CDS             complement(17835..18629)
                     /locus_tag="VXE25_000681"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000363010.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphotransferase family protein"
                     /protein_id="HEV0771188.1"
                     /translation="MDLGDNELTLTPIPGKSGKAYMGSYPDGKRIFVKMNTSPILPGL
                     AREQIAPQLLWSRRLADGRDMCAQEWLTGKILTPYDMNRKQIVNILTRLHRSRPLMTQ
                     LSRLGYAMETPVDLLQSWQETAPDALRKNHFISEVMADLRQTIPGFREDHATIVHGDV
                     RHSNWIETDSGLIYLVDWDSVRLTDRMFDVAHMLCHYISEHQWKEWLTYYGYKYNQTV
                     LSKLYWYGQLSYLSQISKYYMNQDLENVNREIHGLRHFRDKYGKRR"
     gene            complement(18790..19401)
                     /locus_tag="VXE25_000682"
     CDS             complement(18790..19401)
                     /locus_tag="VXE25_000682"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000394041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEV0771189.1"
                     /translation="MEFFDKFHALCFGFLVLIIVITVPYTINHGDFFQNESALIIVSL
                     LVTSLSVAYARKFEMISFGMLSKKQLLLFIVIFLLSVLETLVYIHFFAVSSGSGVQHL
                     AEVSRGISLSLILTTSVFGPIQEELIFRGLLQGAFFDNSWLGLVLTSSLFSFMHGPSN
                     VPSFIFYLLGGLLLGLAYKKSQNLWVSTLVHMFYNSWPLLYYL"
     gene            complement(19552..19785)
                     /locus_tag="VXE25_000683"
     CDS             complement(19552..19785)
                     /locus_tag="VXE25_000683"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809974.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771190.1"
                     /translation="MYKHLFFLDSKTLDRLTPYILVLSSDTIAFNVFVLTFVSAVVFN
                     FLNSMLALMAIFIGAGYVVGFWLLILNENQRAN"
     gene            complement(19827..20516)
                     /locus_tag="VXE25_000684"
     CDS             complement(19827..20516)
                     /locus_tag="VXE25_000684"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000760553.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEV0771191.1"
                     /translation="MKKYQLLFKISAVFSYLFFVFGLSQLTLIVQNYWQFSSQIGNFV
                     WIQNILSLLFSGVMIWILVKTGHGYLFRIPRKKWLWYSILTVLVLVLQISFNVQIAKH
                     VQSTAEGWAVLIGYSGTNFAELGIYVTLFFLTPLMEELIYRGLLQHAFFKHSRFGLDL
                     FLPSILFALPHFSSLPSLLDIFVFATFGIIFAGLTRYTKSIYPSYAVHVINNIVATFP
                     FLLTFLHRVLG"
     gene            complement(20531..20950)
                     /locus_tag="VXE25_000685"
     CDS             complement(20531..20950)
                     /locus_tag="VXE25_000685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000877385.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="immunity protein"
                     /protein_id="HEV0771192.1"
                     /translation="MKYRLFFVIFLSSVLDILLGTFLQISIVSIGWLVLYSGLFEVGV
                     FLLANKGVAVKIKEVDIRNRFKFIFGKTLWFQILLLIFLIIKLYLGLDARLILFYGHI
                     FIVFNALMYLLSSSQVSLKKTNCLLNLTAVESDKVRS"
     gene            complement(21736..21855)
                     /locus_tag="VXE25_000686"
     CDS             complement(21736..21855)
                     /locus_tag="VXE25_000686"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000346296.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin"
                     /protein_id="HEV0771193.1"
                     /translation="MDFKSFIIGLVVGIFGPYMDDLIRKIFSKSSKKDTDSTL"
     gene            complement(21959..22108)
                     /gene="blpO"
                     /locus_tag="VXE25_000687"
     CDS             complement(21959..22108)
                     /gene="blpO"
                     /locus_tag="VXE25_000687"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001818346.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-like peptide BlpO"
                     /protein_id="HEV0771194.1"
                     /translation="MNTKMMSQFSVMDNEMLACVEGGDIDWGRKISCAAGVAYGAIDG
                     CATTV"
     gene            complement(22352..22555)
                     /gene="blpN"
                     /locus_tag="VXE25_000688"
     CDS             complement(22352..22555)
                     /gene="blpN"
                     /locus_tag="VXE25_000688"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001099492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-peptide bacteriocin subunit BlpN"
                     /protein_id="HEV0771195.1"
                     /translation="MNTYCNINETMLSEVYGGNSGGAAVVAALGCAAGGVKYGRLLGP
                     WGAAIGGIGGAVVCGYLAYTATS"
     gene            complement(22571..22825)
                     /gene="blpM"
                     /locus_tag="VXE25_000689"
     CDS             complement(22571..22825)
                     /gene="blpM"
                     /locus_tag="VXE25_000689"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000379879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-peptide bacteriocin subunit BlpM"
                     /protein_id="HEV0771196.1"
                     /translation="MDTKIMEQFHEMDITMLSSIEGGKNNWQTNVLEGGGAAFGGWGL
                     GTAICAASGVGAPFMGACGYIGAKFGVDLWAGVTGATGGF"
     gene            complement(22975..23779)
                     /locus_tag="VXE25_000690"
                     /pseudo
     CDS             complement(22975..23779)
                     /locus_tag="VXE25_000690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="programmed frameshift; internal stop; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS5 family transposase"
     gene            complement(23977..24381)
                     /locus_tag="VXE25_000691"
     CDS             complement(23977..24381)
                     /locus_tag="VXE25_000691"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000846948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="immunity protein"
                     /protein_id="HEV0771197.1"
                     /translation="MKTFLAKKRNIFLARLFLGQLPLLVSTYLFLSRQFLNFSVVFQF
                     LLVVINLASILVTVYLTREMRIREFEDDDLVSPRTNQLMFIGLTGFMSIICLYRGITA
                     GESYQQLIAYIGAVLCLIIMLLLMWGLKYYKK"
     gene            complement(24378..24542)
                     /locus_tag="VXE25_000692"
     CDS             complement(24378..24542)
                     /locus_tag="VXE25_000692"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000727119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771198.1"
                     /translation="MKKKILIIFVLYLIMSIFLYPLRESAWYQLFYTIAYVIAVMIYF
                     AINKKKGEKK"
     gene            complement(24839..24958)
                     /locus_tag="VXE25_000693"
     CDS             complement(24839..24958)
                     /locus_tag="VXE25_000693"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin"
                     /protein_id="HEV0771199.1"
                     /translation="MDFKSFIIGLVVGIFGPYMDNLIRKIFSKFPKKDTDSTP"
     gene            complement(24961..25191)
                     /gene="blpU"
                     /locus_tag="VXE25_000694"
     CDS             complement(24961..25191)
                     /gene="blpU"
                     /locus_tag="VXE25_000694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-like peptide BlpU"
                     /protein_id="HEV0771200.1"
                     /translation="MDTKMMSQFSVMDTEMLACVEGGGCNWGDFAKAGVGGAAARGLQ
                     LGIKTGTWQGAATGAAGGAILGGVAYAATCWW"
     gene            complement(25260..25529)
                     /gene="blpJ"
                     /locus_tag="VXE25_000695"
     CDS             complement(25260..25529)
                     /gene="blpJ"
                     /locus_tag="VXE25_000695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-like peptide BlpJ"
                     /protein_id="HEV0771201.1"
                     /translation="MNTKMLSQLEVMDTEMLAKVEGGYSSTDCQNALITGVTTGIITG
                     GTGAGLATLGVAGLAGAFVGAHIGAIGGGLTCLGGMVGDKLGLSW"
     gene            complement(25996..26193)
                     /gene="blpI"
                     /locus_tag="VXE25_000696"
     CDS             complement(25996..26193)
                     /gene="blpI"
                     /locus_tag="VXE25_000696"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-like peptide BlpI"
                     /protein_id="HEV0771202.1"
                     /translation="MNTKMMEQFSVMDNEELEIVSGGRGNLGSAIGGCIGAVLLAAAT
                     GPITGGAATLICVGSGIMSSL"
     gene            26475..27062
                     /locus_tag="VXE25_000697"
     CDS             26475..27062
                     /locus_tag="VXE25_000697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase C39"
                     /protein_id="HEV0771203.1"
                     /translation="MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKT
                     NKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDVPYPFIVHVNKEGKLQHYYVVYQ
                     TKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
                     SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLR"
     gene            26989..28632
                     /locus_tag="VXE25_000698"
     CDS             26989..28632
                     /locus_tag="VXE25_000698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010976436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide cleavage/export ABC transporter"
                     /protein_id="HEV0771204.1"
                     /translation="MVLSSLLVTIINIGGSYYLQGILDEYIPNQMKSTLGIISVGLVI
                     TYILQQVMSFSRDYLLTVLSQRLSIDVILSYIRHIFELPMSFFATRRTGEIISRFTDA
                     NSIIDALASTILSLFLDVSILILVGGVLLAQNPNLFLLSLLSIPIYMFIIFSFMKPFE
                     KMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLSKYS
                     ILQTSLKQGTKLVLNILILWFGAQLVMSSKISIGQLITFNTLFSYFTTPMENIINLQT
                     KLQSAKVANNRLNEVYLVESEFQVQENPVHSHFLMGDIEFDDLSYKYGFGRDTLTDIN
                     LTIKQGDKVSLVGVSGSGKTTLAKMIVNFFEPYKGHISINHQDIKNIDKKVLRRHINY
                     LPQQAYIFNGSILENLTLGGNHMISQEDILKACEVAEIRQDIERMPMGYQTQLSDGAG
                     LSGGQKQRIALARALLTKSPVLILDEATSGLDVLTEKKVIDNLMSLTDKTILFVAHRL
                     SIAERTNRVIVLDQGKIIEVGSHQELMQAQGFYHHLFNK"
     gene            28643..30004
                     /locus_tag="VXE25_000699"
     CDS             28643..30004
                     /locus_tag="VXE25_000699"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001069090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin secretion accessory protein"
                     /protein_id="HEV0771205.1"
                     /translation="MNPNLFRSVEFYQRRYHNYATVLIIPLSLLFTFILIFSLVATKE
                     ITVTSQGEIAPTSVISSIQSTSDNPILANHLVANQVVEKGDLLIKYSETMEESQKTAL
                     ATQLQRLEKQKEGLGILKQSLEKATDLFSGEDEFGYHNTFMNFTKQSHDIELGITKTN
                     TEVSNQANLANSSSSAIEQEITKVQQQIGEYQELRDAIINNRARLPTSNPHQSILNRY
                     LVASQGQTQGTAEEPFLSQINQSIAGLESSIASLKIQQAGIGSVATYDNSLATKIEVL
                     RTQFLQTASQQQLTVENQLTELKVQLDQATQRLENNTLTAPSKGIVHLNSEFEGENRI
                     PTGTEIAQVFPIITDTREVLITYYVASDYLPLLDKGQTVRLKLEKIGNHGITIIGQLQ
                     TIDQTPTRTEQGNLFKLTALAKLSNEDSKLIQYGLQGRVTSVTAKKTYFDYFKDKILT
                     HSD"
     gene            30061..30216
                     /gene="blpC"
                     /locus_tag="VXE25_000700"
     CDS             30061..30216
                     /gene="blpC"
                     /locus_tag="VXE25_000700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quorum-sensing system pheromone BlpC"
                     /protein_id="HEV0771206.1"
                     /translation="MDKKQNLTSFQELTTTELNQITGGGWWEELLHETILSKFKITKA
                     LELPIQL"
     gene            complement(30258..31598)
                     /locus_tag="VXE25_000701"
     CDS             complement(30258..31598)
                     /locus_tag="VXE25_000701"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001099894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEV0771207.1"
                     /translation="MNIAWILLYTLVTNGLEIVIFFKVDGIDLTFERIFKAFLFKILL
                     AFVFVMISYIVGNVYLSYFMEPLYGIGLSFLLLRGLPKKLLFFYGLFPMILVNLFYRG
                     VSYFVLPFLGQGQVYDGYSFTGLCIIIFNFFISLAFLKWLDYDFTSLRKEILDKAFQK
                     SLTQINWIMGGYYLVMESLSFFEYEQSIQSKTVRHLILVFYLLFFMGVIKKLDTYLKE
                     KLYERLEQEQALRYRDMERYSRHIEELYKEVRSFRHDYTNLLTSLRLGIEEEDMEQIK
                     EVYGSVLKDSSQKLQNNKYDLGRLVNIRDKAFKSLLAGKFLKARDKNIVFNVEVPEEI
                     QVEGMSLLDFLTIVSILCDNAIEASVEASQPHVSIAFLKNGAQETFIIENSIKEEGID
                     ISEIFSFGASSKGEERGVGLYTVMKIVESHPNTSLNTTCQNQVFRQVLTVIHTE"
     gene            complement(31612..32349)
                     /locus_tag="VXE25_000702"
     CDS             complement(31612..32349)
                     /locus_tag="VXE25_000702"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001219153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEV0771208.1"
                     /translation="MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLL
                     AEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRDPYALIVFVTTHSEFMPLSFRYQ
                     VSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
                     LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKL
                     LFFPNGGSCLIARYKVREVSEAINKLH"
     gene            complement(32354..32692)
                     /locus_tag="VXE25_000703"
     CDS             complement(32354..32692)
                     /locus_tag="VXE25_000703"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000682119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEV0771209.1"
                     /translation="MKHMIIQTQKTVYKVNVDDIYYIQTHPTKAHTVQIVTEKASFNM
                     LQNLSNLENQCGETLMRCHRNCLVNLDKLKSIDFQERILFLGEEGQYAVKYARRRYRE
                     IRQKWLKEGE"
     gene            32969..33298
                     /locus_tag="VXE25_000704"
     CDS             32969..33298
                     /locus_tag="VXE25_000704"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864062.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase BlpT"
                     /protein_id="HEV0771210.1"
                     /translation="MTDTDPIKRAHTLITDLNKAYQACKQASADDVRFQEQLNSILGF
                     LAKAETVDNRFLIELEKFYQTSSLLMGLSALDPDAPTRAAWRAYDRFHFDQVKTKLIL
                     NENQRAN"
     gene            complement(33466..34515)
                     /locus_tag="VXE25_000705"
     CDS             complement(33466..34515)
                     /locus_tag="VXE25_000705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399209.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEV0771211.1"
                     /translation="MKDLFLKRKQAFRKECLGYLRYVLNDHFVLFLLVLLGFLAYQYS
                     QLLQHFPENHWPILLFVGITSVLLLLWGGIATYMEAPDKLFLLVGEEEIKLHLKRQTG
                     ISLVFWLFVQTLFLLLFAPLFLAMGYGLPVFLLYVLLLGVGKYFHFRQKASKFFTETG
                     LDWDYLISQESKRKQVLLRFFALFTQVKGISNSVKRRAYLDFILKAVQKVPGKIWQNL
                     YLRSYLRNGDLFALSLRLLLLSVLAQVFIEQAWIATAVVVLFNYLLLFQLLALYHAFD
                     YQYLTQLFPLDKGQKEKGLQEVVRGLTSFVLLVELVVGLITFQEKLALLALLGAGLVL
                     LVLYLPYQVKRQMQD"
     gene            complement(34512..35243)
                     /locus_tag="VXE25_000706"
     CDS             complement(34512..35243)
                     /locus_tag="VXE25_000706"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000889926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0771212.1"
                     /translation="MLEIKNLTGGYVHVPVLKDVSFTVESGQLVGLIGLNGAGKSTTI
                     NEIIGLLAPYSGSININGLTLQGDATSYRKQIGYIPETPSLYEELTLREHIETVAMAY
                     GIEQKVAFERVEPLLKMLRLEQKLDWFPVHFSKGMKQKVMIICAFVVDPSLFIVDEPF
                     LGLDPLAISDLIQLLEVEKQKGKSILMSTHVLDSAEKMCDAFVILHKGEVRAKGNLLQ
                     LREAFDMPEASLNDIYLALTKEEDL"
     gene            35311..35721
                     /locus_tag="VXE25_000707"
     CDS             35311..35721
                     /locus_tag="VXE25_000707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006150090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HIT family protein"
                     /protein_id="HEV0771213.1"
                     /translation="MSDCIFCKIIAGEIPASKVYEDEQVLAFLDISQVTLGHTLVVPK
                     EHYRNLLEMDATSASQLFAQVPKVAQKVMKVTKAAGMNIISNCEEVAGQTVFHTHVHL
                     VPRYSADDDLKIDFIAHEPDFDKLAQIAETIKNA"
     gene            35731..36018
                     /locus_tag="VXE25_000708"
     CDS             35731..36018
                     /locus_tag="VXE25_000708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000777751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771214.1"
                     /translation="MKLSNLLLFAGAAAGSYLVTKNRQTITDEVLNTTDRVQAIKDDV
                     DIIQNSLQIINQQKELIKEYQEDLTYKFKVLEKDIQTRLAVIKEMQGTEDK"
     gene            36180..36419
                     /locus_tag="VXE25_000709"
     CDS             36180..36419
                     /locus_tag="VXE25_000709"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771215.1"
                     /translation="MHHNLGNSYSIKIKKQTRKLGTDCSKHRFKVVDRTDEVSSKHCF
                     EVVDRTDEVSNHTHGKPTLTWFEEIFEEYYSPFHN"
     gene            complement(36753..37889)
                     /gene="dnaJ"
                     /locus_tag="VXE25_000710"
     CDS             complement(36753..37889)
                     /gene="dnaJ"
                     /locus_tag="VXE25_000710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001066288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone DnaJ"
                     /protein_id="HEV0771216.1"
                     /translation="MNNTEFYDRLGVSKNASADEIKKAYRKLSKKYHPDINKEPGAED
                     KYKEVQEAYETLSDDQKRAAYDQYGAAGANGGFGGAGGFGGFNGAGGFGGFEDIFSSF
                     FGGGGSSRNPNAPRQGDDLQYRVNLTFEEAIFGTEKEVKYHREAGCRTCNGSGAKPGT
                     SPVTCGRCHGAGVINVDTQTPLGMMRRQVTCDVCHGRGKEIKYPCTTCHGTGHEKQAH
                     SVHVKIPAGVETGQQIRLAGQGEAGFNGGPYGDLYVVVSVEASDKFEREGTTIFYNLN
                     LNFVQAALGDTVDIPTVHGDVELVIPEGTQTGKKFRLRGKGAPSLRGGAVGDQYVTVN
                     VVTPTGLNDRQKVALKEFAAAGDLKVNPKKKGFFDHIKDAFDGE"
     gene            complement(38291..38647)
                     /locus_tag="VXE25_000711"
     CDS             complement(38291..38647)
                     /locus_tag="VXE25_000711"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000114361.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanine-N7)-methyltransferase"
                     /protein_id="HEV0771217.1"
                     /translation="MSVLDEEYLKNTRKVYNDFCNQADNYRTSKDFIDNIPIEYLARY
                     REIILAEHDSCVKNDEAVRNFVTSVLLSAFVSAMVSAMISLEIQTYKFVIPFIIGMIW
                     TVVVFLMINWNYIGKY"
     gene            complement(38649..40472)
                     /gene="dnaK"
                     /locus_tag="VXE25_000712"
     CDS             complement(38649..40472)
                     /gene="dnaK"
                     /locus_tag="VXE25_000712"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002946936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone DnaK"
                     /protein_id="HEV0771218.1"
                     /translation="MSKIIGIDLGTTNSAVAVLEGTESKIIANPEGNRTTPSVVSFKN
                     GEIIVGDAAKRQAVTNPDTVISIKSKMGTSEKVSANGKEYTPQEISAMILQYLKGYAE
                     DYLGEKVTKAVITVPAYFNDAQRQATKDAGKIAGLEVERIVNEPTAAALAYGLDKTDK
                     EEKILVFDLGGGTFDVSILELGDGVFDVLSTAGDNKLGGDDFDQKIIDHLVAEFKKEN
                     GIDLSTDKMAMQRLKDAAEKAKKDLSGVTSTQISLPFITAGEAGPLHLEMTLTRAKFD
                     DLTRDLVERTKVPVRQALSDAGLSLSEIDEVILVGGSTRIPAVVEAVKAETGKEPNKS
                     VNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK
                     SQVFSTAADNQPAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGIPQIEVTFDIDK
                     NGIVSVKAKDLGTQKEQTIVIQSNSGLTDEEIDRMMKDAEANAESDKKRKEEVDLRNE
                     VDQAIFATEKTIKETEGKGFDAERDAAQAALDDLKKAQEDNNLDDMKAKLEALNEKAQ
                     GLAVKLYEQAAAAQQAQEGAEGAQATGNAGDDVVDGEFTEK"
     gene            complement(40961..41485)
                     /gene="grpE"
                     /locus_tag="VXE25_000713"
     CDS             complement(40961..41485)
                     /gene="grpE"
                     /locus_tag="VXE25_000713"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000046028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotide exchange factor GrpE"
                     /protein_id="HEV0771219.1"
                     /translation="MAQDIKNEEVEEVQEEEVVETAEETTPEKSELDLANERADEFEN
                     KYLRAHAEMQNIQRRANEERQNLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVKKG
                     LGMVQESLIHALKEEGIEEIAADGEFDHNYHMAIQTLPADDEHPVDTIAQVFQKGYKL
                     HDRILRPAMVVVYN"
     gene            complement(41512..42546)
                     /gene="hrcA"
                     /locus_tag="VXE25_000714"
     CDS             complement(41512..42546)
                     /gene="hrcA"
                     /locus_tag="VXE25_000714"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heat-inducible transcriptional repressor HrcA"
                     /protein_id="HEV0771220.1"
                     /translation="MVTERQQDILNLIIDIFTKTHEPVGSKALQESINSSSATIRNDM
                     AELEKQGLLEKAHTSSGRMPSVAGFQYYVKHSLDFDRLAENEVYEIVKAFDQEFFKLE
                     DILQEAANLLTDLSGCTVVALDVEPSRQRLTAFDIVVLGQHTALAVFTLDESRTVTSQ
                     FLIPRNFLQEDLLKLKSIIQERFLGHTVLDIHYKIRTEIPQIIQRYFTTTDNVIDLFE
                     HIFKEMFNENIVMAGKVNLLNFANLAAYQFFDQPQKVALEIREGLREDQMQNVRVADG
                     QESCLADLAVISSKFLIPYRGVGILAIIGPVNLDYQQLINQINVVNRVLTMKLTDFYR
                     YLSSNHYEVH"
     gene            complement(42710..43219)
                     /locus_tag="VXE25_000715"
     CDS             complement(42710..43219)
                     /locus_tag="VXE25_000715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001088691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2812 domain-containing protein"
                     /protein_id="HEV0771221.1"
                     /translation="MNSRVEFRIFTIVDLDKKEEYLHEMHLKGWRYRTSRFGLFYFEQ
                     GQPDDVIYRIYDSRFLKEHKRELQDFRDRGWELIGAGSCSILRKSSSDLLPEDQVYMS
                     KGLKWEVMRSRLRSCIATFLGGLVVCMSLFREDLSMSFFLIFVLYAFLISYLIHGYFR
                     LKRKYRVDE"
     gene            43824..46157
                     /locus_tag="VXE25_000716"
     CDS             43824..46157
                     /locus_tag="VXE25_000716"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase family protein"
                     /protein_id="HEV0771222.1"
                     /translation="MVEFIKSKKEMSEEDIKANFITPAIVSKGWKNGEHIAYEEYFTD
                     GRIEVRGDKARRKEGKKSDYSLYYQFGTRIAIVEAKDNKHSVRAGLQQAIEYGEILDV
                     PFVYSSNGDGFIEHDRITREERELELDEFPTREELFSRMTKEKGLTYEITEAISTPYY
                     TDAFSMKTPRYYQQIAINRTIETVARGQKRVMFVMATGTGKTFMAFQIIHRLRKAGLA
                     KRVLFLADRNILVDQTMAEDFRPFEKVMTKITPKLLTAPEKLNSFEIYLGLYQQLTGE
                     DGTETHYQKFDKDFFDLIVIDEAHRGSAKEDSNWRKVIDYFSSATQIGMTATPKETKN
                     ASNTEYFGEPIYTYSLKQGIEDGFLAPYRVMRVNLDVDVDGYRPETGKVDTNGQLIED
                     RYYGRKDFDKTIVIDDRTQRVAKFVSDYMKQNNARFDKTIVFCVDIDHAERMRAALVK
                     ENLDLVQEDYRYVMQVTGDNAEGKAQLDNFMDVNSNFPAIVTTSKLLTTGVNAKTCRL
                     IVLDSNIQSMTEFKQIIGRGTRLYPQKGKEFFTIIDFRNVTNLFADPDFDGEPVKVLE
                     TGAKTVSGSTPGFVDEEGDPVEKYIVTDKQVTILNSTVQVLDENGKLITESLTDYTRK
                     NILGSYATLNDFITVWHTADKKKLILDELYKKGVYLDAIRESEGISEQEIDDFDLLLK
                     LAYGQKELTKTERINKLKQSGYLYKYSEEARAVLEILLNKYMDKGIGELESIETLKLP
                     EFQIYGGTFKIINTYFGDKKRYLQAIKELEQELFTVA"
     gene            46170..47633
                     /locus_tag="VXE25_000717"
     CDS             46170..47633
                     /locus_tag="VXE25_000717"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000029054.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent DNA methyltransferase"
                     /protein_id="HEV0771223.1"
                     /translation="MSITSFVKRIQDITRNDAGVNGDAQRIEQMSWLLFLKIYDSREM
                     VWELEEDEYESIIPEELKWRNWAHAQNGERVLTGDELLDFVNNKLFKELKELEITSNM
                     PIRKTIVKSAFEDANNYMKNGVLLRQVINVIDEVDFNSPEDRHSFNDIYEKILKDIQN
                     AGNSGEFYTPRAATDFIAEVLDPKLGESMADLACGTGGFLTSTLNRLSSQRKTSEDTK
                     KYNTAVFGIEKKAFPHLLAVTNLFLHEIDDPKIVHGNTLEKNVREYTDDEKFDIIMMN
                     PPFGGSELETIKNNFPAELRSSETADLFMAVIMYRLKENGRVGVILPDGFLFGEGVKT
                     RLKQKLVDEFNLHTIIRLPHSVFAPYTGIHTNILFFDKTKKTEETWFYRLDMPDGYKN
                     FSKTKPMKSEHFNPVRDWWENREEILEGKFYKSKSFTPSELAELNYNLDQCGFPKEEE
                     EILNPFELIQNYQAERATLNHKIDNVLADILQLLEDK"
     gene            47633..>48418
                     /locus_tag="VXE25_000718"
     CDS             47633..>48418
                     /locus_tag="VXE25_000718"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000187262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HEV0771224.1"
                     /translation="MTPEQLKASILQRAMEGKLVPQNPNDEPASELLKRIKAEKEKLI
                     SEGKIKRDKKETEIFRGDDGKHYGKFADGSTQEIDVPYDIPDTWEWVRIKSIYWNFGQ
                     NKPEKSFRYIDTSSIDRKKNIINYKNLQYLSPEQAPSRARKLVSQNSVLFSTVRPYLK
                     NIAVVRELKEYLIASTAFIVLDTLLNETYLKYYLLSDNFINRVNNKSTGTSYPAINDY
                     NFNLLLIALPPLSEQQRIVEAIESALEKVDEYAESYNRLEQLDK"
BASE COUNT        14891 a        10262 c         8698 g        14567 t
ORIGIN      
        1 gacctactac tatcacttga aacagctaga caaaacagat aaggaccaag agcttaaagc
       61 tgaaattcaa tccattttta tcgaacacaa gggaaattat ggttatcgtc ggatttattt
      121 agaactaaga aatcgtggtt atctggtaaa tcataaaaga gttcaaggct tgatgaaagt
      181 actcaattta caagctaaaa tgcgacagaa acgaaaataa aggagacgtt ggtaagaagg
      241 cagagaatct cattcaaggc caatttgaag gatctaaaac aatggaaaag tgctacacag
      301 atgtgacaga atttgccatt ccagcaagta ctcaaaagct ttacttatca ccagttttag
      361 atggctttaa cagcgaaatt atcgcctata atctttcaac ttcacccaac ttagaacaag
      421 tacaaacaat gttggaacag gcattcacag agaagcacta cgagaatacg attctccata
      481 gtgaccaagg ctggcaatac cgacacgatt cttatcatcg gttcctaaga gtaagggaat
      541 tcaagcatct atgtcacgca agggaaacag ccaagacaac ggtatgatgg agtccttctt
      601 tgggattctg aaatcggaaa tgttttatgg ctatgagaaa acatttaaat cacttaatca
      661 attggaacaa gctattgtag actatattga ttactacaac aataaacgaa ttaaggtaaa
      721 actaaaagga cttagccttg tgcaatacag aactaaatcc ttcggataaa ttatttgtct
      781 aactttttgg ggtcagtaca cctaaaactt tgatgatata cgttttcttg tgagaatatt
      841 tacttcattt ttgcctaaaa ttcaatgttt actcagtatt tggattatga aaaatcgagg
      901 tctaaatcta gatacatttt ttctgaagac aaatcatttt gaccaccgag caagagattt
      961 tcaaaaaaag ctgttaaaaa ctcagaacgt cgctgtaaaa tctttgcatt atctaatacc
     1021 aaggcatcac gaaaatattt ggaatgttgc tgaaatggtg tattatcaat atcaaaacca
     1081 aactcacgaa gatactgaat caaaaagacc gttactgtcc gagtgtttcc ttcgcgaaat
     1141 ggatgaatct gccagattcc tgaaataaaa tgctggattt gtttaaccac atccgcctga
     1201 gttagtgtcg catatgcaac ttgtttttcc tgattaaaat cataatctaa ggtcatttga
     1261 atcatggagt aatcagagta cacaacactt tcaccattca aaacaggttc attctttgtg
     1321 atattggtct gacgaaattg ccccaccgga atagagggtt caaatatatc ttgaaacaac
     1381 tccttatgaa tagcaagtaa ggtcgcagga ctaaagctaa agcctcttcg agacaatagt
     1441 tctacaatac gtagagaaac caagtctgcc tcttccgtac ttgcatcaat agtatggtga
     1501 taagccgttg cattctcata aacctgctca taagtcagtt ctccccggga ctgtttctca
     1561 gccaaagatt ccatatacgc tgatggcact agattgtcaa ctttctgcag accaaaacct
     1621 atccgccata aatcacgctt cgcttcataa gacaagtttg gattgtcaat gttgtaagtt
     1681 gattgcatag aaatatcctt tcaattgttt ttcttcatta ccagtaaatc acgaaattgg
     1741 ttggaaactg gcttaaacta taaaaagtcc tcacaatagg ttctatgata tatatatata
     1801 cttcatgtaa ataataaaag agttataatc agcactactg ataaattcaa taccgatttc
     1861 gccatcttaa aacttagtca aacgaatacc gttgatttcc agttcattaa gtcgttgacc
     1921 tgtcaagact tctcgttcct tcaactggaa aagttaaggg ggaactaata caaatcctct
     1981 acgcttctat attcaatgat ttcatttttg ataatattct ttttaaactc aaaatgtttt
     2041 aaaggattat cgattaacac taactttgga atatcatcta gatttgtgac caaggataaa
     2101 ataaaatccg attgaaactc cttgactttt tcaaattctt ttgcagttaa acgcacacgc
     2161 cccttagatt ttcggatacc ttttacttcg gcaaggtaag aatactcttg gacatctacc
     2221 tgaaagtcat atccatcacc ataaagacgg gcatcggtta actgtccacc ttggaatttt
     2281 tcttctttat caaaatgaag gataaaataa ttctcagcct ccattcccgt ttcctgtaga
     2341 cgtttgaatt tagttcgaac tattggtttt tcaacgatgg ttatgcctgt tttcttccct
     2401 tcactggcaa gtaacatttt aactatttca gcataactat gaacatcttc atttccaaac
     2461 atcatatcaa ttaaatcttt acgaaaacga taaacttcag ctttctgcca ccaacctttt
     2521 cgattattgt caaaataagg atcaaataaa tccattctat tttttacaac tccagttgtt
     2581 tcagcaattc ccagagaaac cacatagcga taaaactccg acttgctaga gcattgaaat
     2641 tcttttataa aaagcttgtc aaacttggca agaccgtagc caattaaatt taacaattca
     2701 taatgagggt gtttggacat cactttctcc atcaatagat attgatttca ttataccaaa
     2761 aaacacggct catcaccgtg tttctgtgtt tatttcacca acttcttcat ctcatcaata
     2821 cgtgctacgg tcgcatcata cttagcttgg taatctgctt gcttgtcgcg ttctttttgg
     2881 acaacttctg gtttagcgtt ggcgacgaag cgttcgttgc tgagtttttt gccaaccatg
     2941 tcgagttctt tctgccattt ggcaagttct ttttccagac gtgccaattc ttcttcgaca
     3001 ttcaagaggt ctaccagtgg caagaagatt tcggctcctg tgatgacgct tgacatagcc
     3061 agttcaggtg cagggatggt tgatgcgatt tccaagtgtt caggatttgt gaaacgtttg
     3121 atgtagttga cattgctgtt aaagaaggct tccaagtcgc tatcgcttgt cttaacaagg
     3181 atagtgatag gcttgcttgg agcaacgttt acttccgcac gcgcattacg aacggcacgg
     3241 atcaagtctt taaggctttc cacaccagtg tgagcagcaa ggtcttcaaa ggctgggttg
     3301 atagttgggt attctgctgt aacgatagat ccttctgaga tttgtccaaa gatttcctct
     3361 gtcacaaatg gcatgattgg gtgaaggaga cgaaggatct tgtccaaagt gtatagtaga
     3421 acagaacgtg tgatgacttt ctcttcttcg ttatcgctat aaaggacttc cttggtcaac
     3481 tcaacatacc agttggcaaa ttcttcccag atgaagttgt aaaggatatg accagccaca
     3541 ccaaactcga acttatcaaa gttttcagta acttttgcaa tggtttcgtt gagattgtgg
     3601 agaatccagc ggtccgtcac attaccagcc tcacctgttg caacttttgt gacattgtca
     3661 tgcgccacat ccagcgtcaa accttcattg ttcatgagga tatagcgaga aatgttccaa
     3721 attttgttaa taaagttcca tgaagcatcc attttctcgt aagagaaacg agcgtcttga
     3781 ccaggagctg agccgtttga caagaaccaa cgaagactat ctgtaccata tttatcaata
     3841 acatccattg ggtcaatgcc atttccaaga gatttagaca tcttacgtcc ttcttcatca
     3901 cgaattagac catggataag agcattttta aatgggctct ttcctgtaaa ttcaattcct
     3961 tggaaaatca tgcgtgatac ccagaaagga ataatatcat agcctgttac gagtgttgaa
     4021 tttggatagt agcgtttaaa gtcagtagtt tcggtattag gccagcccat ggttgagaag
     4081 ggccagaggg cagagctgaa ccaagtgtca aggacatctt cgtcctgttt ccagccatcg
     4141 cccgctgggg cttcctcgcc gacatagatt tcgcctgctt cattatacca agcagggatt
     4201 tggtgacccc accaaagctg acgagagata acccagtcgt ggacattttc catccattga
     4261 aggaaggtat cgttgaaacg aggtgggtag aattcgacct tgtcctctgt gtcttggttg
     4321 gcaatggcgt tcttagccaa ttggtccatc ttgacgaacc attgagtaga caagcgtggc
     4381 tcaactacga cacctgtacg ttctgagtga ccgactgaat ggacacgttt ttcgattttg
     4441 acaagggcac cgatttcttc caacttagca acgactgcct tacgagcttc aaaacgatcc
     4501 atgcctgaaa attcaaaggc aagctcattc atagttccgt cgtcgttcat gacgttgact
     4561 tgtggcaagt tatgacgttg gccaaccaag aagtcatttg gatcgtgggc aggtgtgatt
     4621 ttcacgacac cagtaccaaa ctcaggatct gcgtgctcat ctccaacgat tgggatgagt
     4681 ttattagcga ttggaaggat gacgttttta ccaatcaagt ccttgtagcg cgggtcttct
     4741 ggattaaccg caaccgcaac gtccccaaac atagtctcag gacgagttgt agcaacttca
     4801 agggcgcgtg aaccatcttc cagcatgtag ttcatgtggt agaaggcacc ttcgacatcc
     4861 ttgtgaatca cctcaatatc agaaagggct gtgcgagctg ctgggtccca gttgatgata
     4921 aactcaccac ggtagatcca gcctttcttg taaaggtcca caaagacctt acgaacagct
     4981 tttgacaaac cttcgtcaag agtgaaacgc tcacgagagt agtctacaga gagccccatc
     5041 ttgccccatt gttccttgat agtagtggca tattcgtctt tccattccca gactttcgtc
     5101 aagaaagact cacgaccaag gtcatagcgg gaaatgccct caccacgcaa gcgctcctct
     5161 accttagcct gagtggcaat ccctgcgtgg tccatcccag gaagccaaag ggtatcaaaa
     5221 ccttgcatgc gtttttgacg gatgataata tcttgcaaag ttgtatccca agcgtgacca
     5281 aggtgaagtt tacctgtaac gtttggtggt ggaataacga ttgaataagg cttagccttt
     5341 tgatcgcctg aaggcttgaa aacatcagca tcaagccatt tttggtaacg accagcctca
     5401 acctcggctg gattgtattt agatgaaagt tctttagaca tgtgtgtgtc ctttctctat
     5461 tttgtttatt ttattttgaa tctgcttagc agcttcttct gcagacaaat tcgtattatt
     5521 tattttaaag tagtggtgca actcattcgg ttgatattgg gaatttaatt gaagtgtttc
     5581 agcggtctct aaaatttctc tttcagatac ctcaatatgt cgttttaagg gtttgtgctt
     5641 taatcgattc tccgttcgat ttcgacgtat gcactcttca agacttgttt ccaactcaac
     5701 aaaaagaatc tcttgatgat aatcatccaa caaattctga atttgcttta aatatatcag
     5761 atgatactga tttgaaaaat caattacatc tgttaaaatt actgatcgct gatttcttgc
     5821 acttgctcca aggaatgaaa aagtgattcc acgaacaaat tcccacattt cctctgtata
     5881 gtcctgatag atttctagtg caaaatcaat ggcttgatgg ttataaaata gggtagcatc
     5941 cgtcagtcga gataattctt gaccaatggt catttttcct gatgctggag caccaatgat
     6001 gaaaagatgc atcaaatcac ctcccactcg ctcttcagca agccatatat cagactgtca
     6061 cagcggtttc cttgaacatc ctttcggtct cttatgcgag cttcgagggt aaagccaagc
     6121 ttttccgcga ctcgtttact ttgaaggtta tatccaaagc aagttagttc aatcttgtga
     6181 agacccaaat ctttaaaggc taagtcaatc aaggcacgcg cagcttctgg cacataacct
     6241 cgcccccaat agtctgggtg taaggtatag ccgatttcca gcacatcatc ttcatggcga
     6301 tggttgaaat cgacagagcc aacgatctta tccgttcctt tgacgacaat cccgtagcct
     6361 gctgggagat tttccttttg attacgctcc ggaagaatgt gctccagata ataaatctca
     6421 tcttccaagg tcttgactgg aggaaaacct gctggatagg cgacctctgg caaactagca
     6481 tagtcaaaga tatcctcagc atccgccaca gtacggactc gtaaaacgag acgttctgtt
     6541 tcgattttat ctggcagctc agttcttgcc atccttcttc ctcgcttttt ttgatgaaac
     6601 tgcccttcat atctacacgc ttgtccagat agcgataaac gcgctgatat acatctccca
     6661 tgaaataggt tggggcaaac agttgatttt taaaatgtcc cttttcatcc aggagttctg
     6721 gggcaacaag tcgctcaaga atcttggcaa agatgtggca aataccgtct tcctcaacaa
     6781 tcctatctac ccgacaatct aaaacaagtg gacaggcgtc taaaatagga gtctgagttc
     6841 gttcagaaat ttcataatgc actcccaaac gttccaattt ctcctgatga ctgataaaac
     6901 cagcctgctc catcgcaagc atagaagttt catcagaaat attcacagta aatttttgat
     6961 actgtttgat ctgctctgcg gcattctctc tcgcaacgac tccaattaca acccaatctc
     7021 ctagactata cgaggaacta caggtcgtaa tgttatagcc aaaattctga tcttgatatc
     7081 ctaaaataaa aacaggaaaa ctataatata gtttattagt tttaaatgat tgttttataa
     7141 caacctcctt tgactaagac acaaaagaaa agccctgcca tctacatgac agggacgaat
     7201 gtatttatcc gcggtaccac ccaatttcgg gcagttgccc gcaactctcg tctttaaagc
     7261 aaaaagacac ttttatttca atttttcatc cattagcaac cagttttgac acatttgtgg
     7321 acttctcagc accgccactt tctgtaaaat gtgggattca aaacacctct aatggctcta
     7381 ttgtagcaag tttttctcgg aaatgcaagg ctcaagaaaa attacttgaa cttgatgcca
     7441 ttttctttca atttcttgat ggtagctggg ccgattcctt tcaaggcaag gagttctttt
     7501 tcagtccagt ttttgaaatc tgaagcagac ttgattcctt catcatagaa agtcttggca
     7561 cgatcaagtg gaagtccacc caagtttgct gcaaaatctt ctacagaatt agctactttt
     7621 tgagcttgct ctttggtagc ttctactgct tgttcaactt ttttagaaac tgccttacca
     7681 gctgcgcttg ctgactgttc tgcacgcttc acgacttttt ttgtctcatc tacaacctta
     7741 gtcacagtac ttgaaaaggc acctgcgcga cggaggccat ttcgtaattg ttttttacga
     7801 ttgagtttct ttgacatgat aaaatccttt caataaaaaa tccctgctct gacaaggatt
     7861 taacataaac attctatcaa gattttagtg aaaaatcaag aatctttctc gtttaataat
     7921 ttcgctcacc aaacaagcct tctggcaaat catggaatcc cttgcctgct ttgaagtttt
     7981 caaacttacc aagcaagaac tgataagcat ccaagcgact ctcgtagcga atcatggcat
     8041 ctttggcacg ctcgtcctgg tcttcttcgt aaactttttg gctttccttg tgcgccatgt
     8101 cgttaatcat gatttgggta ttgacccaag cttcaaattc cttcataaat tcttgttcgt
     8161 aactcatttt ttctccttat tctaatccac gaaaatagtc cgtatcaatc tcacggtagg
     8221 gctggatatc ctgaacgtat tccagtacac cttggaattc tccgttttca tcgtgtactg
     8281 cagcataggt gatgtggaca aacttgcctc gcgactcaga cttgaaccac atttcatact
     8341 tgtccttggt cccctcacga agtcccttca tgatagcctt gaccttgtcc aaatacttag
     8401 gcggatgaca gagttcgaca ttgcgcccga cttgggacgg cgtccgtttg aaaatcatct
     8461 catcagctgg cgtattgtca ttgtaatact ggaaaatatc ttctttattg acaaaggtaa
     8521 tctccatagg gagatgattg aggatgagat tggcctgctc gactgaaaga tagccattac
     8581 caaaagcctg ttgactatgg cggtccagca cagcttcctt ttccttaggg gtaaaggtaa
     8641 tggtaaaatg gccttctggc gtatctataa cttgttgaac ttgaccttct gccgtatcta
     8701 gctgtacagg ctcctctgca atcttttcct caataaagct ctgtcgttct ggcacccatt
     8761 tctctgacgg acggatgatg gcatagccat aggcatcgct ctcctccgca atctgaagcc
     8821 agtcatcctg agtaaaagac tcaaggagaa tcatgaggag gatggactct tccttgaaaa
     8881 tcatactttc aaactctatc gcaaaagctt caaaaacttc ctttacactg ctaattgaca
     8941 cttctggtag tgacttggct gtcgttagag ctgtttgaaa gagttcccta atctgatcat
     9001 ccactcccca cataactttg ggaggtgaat cgtgtccata gcgctccatg ataggaaaga
     9061 agagttcttc tttacgttgg taatggatgt caaattgccc cacaagtccc atctgacgca
     9121 ccaagccctt gcgcatctcc gcaagcattt cctcgtcttc catcaactca taggtatcta
     9181 acaatctacg aatgcgaatc aaagctgcac ggagggccaa attttcttcc ttaaagacac
     9241 gaactgggtg acctggatgc tcagtatctg aaacttcgac acctttgata gcatttttaa
     9301 aaagattggc atggacatca cagagttcca taacatcttc aaaggtgaca cctgagtctg
     9361 agttcataag ctcgtgctcc ataagggaaa tctcaatggc tgagacaccc gcaaaggtcg
     9421 catcaaaacg ctcctgaacc gactcaggag aggcgccatt atgcaattct aataaaatat
     9481 cccgtaggac atgaatccgt tcatctgcca ttagtctaat ccaatcactt cgtagccatt
     9541 cgcttccagt gtgcgtacaa tcttgtccat aggagttcct gctagcttag aaccctgttt
     9601 aagtgatact ttacgaccaa ctgtattgcg cattaaggga ttggcaaggg gtttaaaacc
     9661 caactccact agaatttcca agacttctgg atgcttgtcc accacttctg caacaggaat
     9721 tgacacatcg atgatattgt ccatgacgac ctccattgta tgttctaata ctcaatgaaa
     9781 atcaaagagc aaactaggaa gctagccgca ggttgctcaa aacagtgttt tgaggttgtg
     9841 gatagaactg acgaagtcag taacatatat acagcaaggt gaagctgacg tggtttgaag
     9901 agattttcga agagtataaa atgattttac tgcttatatt ataccatatg gaaagagaat
     9961 aaaaaactag cagtggagtt cctgctagtt ctctgcgact tggattacca tctagataag
    10021 tttaaagagc caatccaata tcttaaataa tatcttgtaa aacagcaatt ggactgcaaa
    10081 agaaatgatc atccaaaaga atttcacaat ctcaataatc ggtttgataa aaagaatagc
    10141 aagaagacca aaaaaatttc attctctctc ctctggctta atgagccacc gagccgtatc
    10201 cattagctta tctgcaataa agagttttcc cagaccaaca acgacatggt catctttctt
    10261 tatcgttttc atcactttta caccttgcac ggtcaaaaag taattaccat aaattttagc
    10321 tagagttttt atgagtccca tattactctc cttcgatgat ttcagcctct tttcggattg
    10381 tttcaacatc ttcttgatat tgaacttcac tatagttaac tagcttggac aattctttct
    10441 gcaagctttc acccatcggt ttcatagttg caaaggttaa accacctgaa atgataccac
    10501 ccaagatagg aataaatttc cccattcctt tggccagccc tcccttggta agattcacac
    10561 caaatattct taaaactttt ttcaaaataa gataccaaag cgtctttgtt aaagctttat
    10621 taggtactgt tttcattacc tgtttggcaa ttgttatacc accagcacgt agcaaagcag
    10681 cagttccatt cacccccaac atgacgccta gataaagcaa aagggtattt tgagcatctt
    10741 cactcaactc atcgcgtgaa gcccaaagat cctcataacc ataaatataa cctaattctt
    10801 gggccaattt cagagagaaa ccataaaatt gagccacatc agctggaatg gtaattgcca
    10861 tagcaagccc tccaggtaat cctgccaaaa cagaagtccc actcgctaat aaaacattat
    10921 ccctaataca ggcattagcc actcgatcta agatttcttg agataagaga gacgttggac
    10981 cttgttccaa taaggtagga atgtcctgtg gacccaattc tttggaaaac ttatccacta
    11041 aaaatttcga acgatcaacc ttaacaactg gtagttttac cacttgttgt aatacttgca
    11101 tagctaagtc ttgttcagcc atatacaaac tccttatttc ttttttacac cttatcatat
    11161 tatatttcct acaaaaaaag cattttctaa ttagataaca ttaaaaaata cagaacccct
    11221 tttttatagt aaaatgaaac aagaacagga caaatcgatc aggacagtca aatcgatttc
    11281 taacaatatt ttagaagtag aggcgtacta ttctagtttc aatctattat aaaagaatat
    11341 ttttccattt caaattcaac ctattttcct ccaccaaaaa agaggggcaa cccctcttct
    11401 ttagttctta tccagattgc gtagcatctc gtcaatcttg tttccatact cgatggactc
    11461 gtctttgacg aaggtcaaat ctgggatttt gtacaatttc aaattgcgac caagttcacg
    11521 tttgatggta ccagttgctt tttcaagccc gatttgggct ttttggttat ccgaagcaag
    11581 gttactcaaa atggtgtaat aaaccttggc aacagacaag tcacccagca tctgaacatc
    11641 tgtgatggtc acaccttgga cacgtggatc acggactttc ttttgcaaaa tctcattgac
    11701 ttcacgcttg atttccatgc ccacacgatc tgtacggaaa tgatttgcca tgatattcct
    11761 ttctctactt tgaaccaaaa gctaggccag cagacctagc tattttaaac ttcttgattt
    11821 tcagtttaaa ttgaaacgaa gttcaatttg aagtcatctg cttctttcgc cgtggtgaaa
    11881 gtgatggaac tgatttatca gtcccatcac gggggatttt tgagacccta ggctcaaaaa
    11941 taagcaatga aaccatcggt ttgcttgcgt ccctcaccac ctaagaaagg agcaaaaaat
    12001 cttatctctt gatttcttcc atgacatacg cctcaatcac atcatccatc ttaatatcat
    12061 tgtagccgtc gatcatcaat ccaccttcac ggccgtttgt aacttcctta acgtcgtctt
    12121 tatagtgttt caagcttgcg agttcaccat catagataac gacaccatca cggataacac
    12181 ggactttaga gtcacgggca accttaccgt tgataaccat aaatccaccg atagttccca
    12241 ctttagacac cttgaaggtt tcacggataa ccgcttcacc aataactttt tcttcaaatt
    12301 ctggatcaag catccctttc atagcttctt ccatctcttc gataaccttg tagataatgc
    12361 tgtgaagacg gatttccaca tcgtcagctt ctgcttgttg acgagcttgt ggtgtagggc
    12421 gtacgttgaa accaacgata aaggcatttg aagcttcggc aagggtcacg tctgattcgt
    12481 tgatagcacc gaccgctgag tggacgatag tcactttgac gccttccacg tcaatctttt
    12541 gaagtgaggc agaaagggct tcaacagaac cttgtacatc agccttgatg ataacattaa
    12601 cagatttgag ttccccagct ttaagggtat caaagaggtt ttcaaggcta acacgttggg
    12661 tagcttgacg ttgtttcatg agggcacgtt tggcacgctc ttcacctgct gcacgcgcag
    12721 atttttcatc ctcgtaaacg gcaaagtggt cacccgccat cggtgcttcg ttcaaacctg
    12781 tgatagagac tggtgttgat ggtccagcaa ctttaacacg acgaccaagg tcgttggtca
    12841 tagcacggac acgaccgaag gtatttccga caacgattgg gtcttgaaca ttcaaggtac
    12901 cttgttgtac aagaagggtt gcgaccgcac cttttccttt atccaagcgc gcttcgataa
    12961 ccgtaccgat tgcacgcact gttgggtctg ccttgagttc ttggatttca gctacaagaa
    13021 ggactgtttc caacaattct tcgatatttt ggttgaattt agctgagatt tcaacaaatt
    13081 cagaatctcc accccaagca gttgacataa ctccatgctc tgccaattca ccgataacgc
    13141 gttctgggtt agcacctggt ttatcaatct tgttaatggc tacgatgatt ggaacgttgg
    13201 ccgcttttga gtggttaatg gcttcgatag tctgaggcat aaccccgtca tctgccgcta
    13261 cgaccaagat cgtaatatcg gtaacagaag caccacgcgc acgcattgat gtaaaggccg
    13321 cgtgtcctgg tgtatcaagg aaggtaatct tcttaccatt ttccacgatt tggtaggcac
    13381 cgatatgctg agtaatacca cctgcttcac ctgtcgcaac acgtgagtta cgaagagtat
    13441 ccaaaagggt tgttttaccg tggtcaacgt gtcccatgat agtaacaact ggtggacgct
    13501 caaccaattc atcttcattg agataaccat cttcgacaaa gaaacgttcg atgtcagcat
    13561 tatccacttc aaccttttgt tttgcttcga taccgtaatc caccatgagg agttcaattg
    13621 tttccccatc caaggattgg ttttgtgtgg ccatgacacc catcatgaaa agtttcttaa
    13681 caatttcagc tggttcacgt ttgatacgtt ttgcgatttc cgcaacggtc ataccatctg
    13741 tatattcaaa ttctgttggc aattcatgga atttacgctc cgtaacaggt tttggagtct
    13801 gattacggtt gttcttgtta ttgccttttt tgttcttttt gttgttattc cagttactat
    13861 tcttttgatt tctcacttga ttttgactac ttcgattctt ttgttgtttt ctaggaccat
    13921 cttcttcatg atcataatcg tcacgatttt tgtctggtcg agcttgtttt ttacgacgtg
    13981 tatccactgc aggttctttt ttctcaggga cgacttcaac cactgcttga acttgctgtg
    14041 cttgttcagc taacttagcc gcttcttcaa agatttcctc tggttccttg cgtttgttag
    14101 cttgagccaa ggcttcttta gcagcctgat actgcttgaa gcgttcctca cttgaacgag
    14161 cgtactctgc attttgctct gcttttaggg ctgctgcacg ggctttaaag tcaatacgtg
    14221 gagccgcttg atttgaacgt ttatcctctt gctgacggcg ctcatttcta cgtttttgct
    14281 gaccttgctg cttcttagct tggtcattaa agcgacgatt gtcgcggttg ctttgacctt
    14341 gttttccacc attacggccg tcgtttttct gacggtttcc gttttgttgt tggtcacggt
    14401 tattgccctt attttgcttg cgtcgttctg cctgctcttt agcacgggct tcacgctcag
    14461 ccttgaaatt acgactttgc ggtttcgctg ctactttttc tgttttcgga gcaactggct
    14521 cagccggttt tgcctcttcc ttagctacag ctggtttagc tggctcagat ttttcggctt
    14581 tcttttctgc acttactttt ggtgctgcag gttttgcttc tactttcgga gcagctgcag
    14641 gcttaaagct ggcagcaatt tttgcagcga cagcttcttc cacacttgat gagtggcttt
    14701 tcacatccaa gcccaactct tttgcacgcg ctacaacttc tttactttct tttccaagtt
    14761 cttttgcgat ttcgtacaat cttttcttag acaaatcatg tcctcctctt ctattccata
    14821 agagacctca ttttctttgt aaatccagca tctgttacag ccaaaacctt tctcgatttc
    14881 ccgactgcta tgcttaattc cagtgttgaa aacacggtta caatttctac ttgataataa
    14941 tgacttttat cttgaatctt cttggtcaga ttgggtccag catcatgagc tagaaagacc
    15001 aacttggcct tgccgtcttg aatggccttg accaccaatt cttcacccga tatgatgcgc
    15061 cctgctcgct gagcaagccc caagagatta cttatctttt gcttattcaa gtcccaactc
    15121 tcttcttttc actttgtgat ccacataagc gatcaactcg tcataaaagc tttcttccac
    15181 ttccatgcta aagctgcggt taaagacctt cttctttttc gcctctaggg cttctgcatt
    15241 gtctagtttg atataagcgc cgcggccatt ggccttgccc gtaggatcaa taaagacttg
    15301 tccttccttg ttcttgacaa tgcggagcaa atcacgctta tcaatcactt cgttagacac
    15361 aacagacttg cgcaaaggga tttttcttgt tttcatcttt ccctcctcta gcagctttta
    15421 ttcttctaca gtatcgtttt ctacttccaa ctctactgaa gcagcgtctt ccatggcttc
    15481 aaattcgcta gcagacttga tatcgatacg ataaccagtc aagtgagccg ccaagcgcac
    15541 gttttgtcca cgacgaccaa tggcaagaga aagcttgtta tctggaacaa ccaccaaggc
    15601 acgtttgctg tcgttttcat caaagataac ttggtcaacc tcagcaggag cgatggcatt
    15661 gtagataaat tcagctggat ctgctaccca ctcgataaca tcgatatttt cttcgattgg
    15721 taccatgcgg tcatttttag catcgtaacg agctgggtgg aatttgctag taatcttctt
    15781 gatattagca ccaccacgtc caacgattgt accgatagca tctacgtttg gattgtggct
    15841 acgaacagca accttcgtac ggtcacctgc ttcacgagcc acgctcatga tttcaacagt
    15901 tccatcataa acttctggaa tttcttgctc catcaaacgt ttgatcattt ctggatggct
    15961 acggctaaca aagacgttca caccacgagg gttgtcttca accttgtaaa cataaacttc
    16021 gatacgatca tgagaagcaa aaacttctcc aggaatttgg tcttgttttg acaattgggc
    16081 ttcgatgcta ccaaggttga catagataaa gcggttgtca aagcgttcta ctgtaccaga
    16141 catgatttct tgctcatgtt ctttgtaagt attgtaagtg atggcacgtg tttgcttgcg
    16201 cattttttcc atgatggttt gtttggcaga ttgggctgct acacgaccaa actcagctgg
    16261 tgcttcttca aacttgattt tgtctccaag ttcataagct gaattaatgg caagagcatc
    16321 tttcaagctg atttccaaac ggctatcaaa tacttcatca acaacttcac ggacagtata
    16381 aactgtaaag tcacctgttt tttcgttgaa gtcaatagct acgctgtctg actgaccata
    16441 gcgtctgcga taagcggaac gaagcgactc tactactgcg tcgatgatat cttctttttt
    16501 gattcccttg tcttcttcca aaatgcggaa ggcctctagc atttctttac tcatgttttc
    16561 ttcacttttg aatcctcaaa agctatcctt tctttttcta taatttaact gctaaacgtg
    16621 cttttgatac taaactgtat ggaatttgga cggttttctt acgcgtcttg tccatatatt
    16681 ccatagtcaa ctcgtcctct tcgaaggcca acaaggttcc ttcaaagacc ttttgcttat
    16741 cgatggcttg gtagagcccg acatggatgt attttccaac ggctccagcg acggcatcct
    16801 tggttttcaa aggacgttcc aagcctggac tggtaatttc taggaaatat tgttctggga
    16861 agggatctgg cttgatggtg tctaggacag gactgatcat ttctgttaag tctgccgtgt
    16921 cgttcaaggt aattccttcg ggtttatcta caaaaatact gagaatcatg tcactgccaa
    16981 tctttccata ctcgatatcc acgagttcaa aaggagcttc tatgacaggt tctacaactt
    17041 ctctgactaa ttctacgatt gttgcgattg cgtccacctc ctcataagca agaggcgaag
    17101 atatttcccc gcctcacttt tcatattctt actatcagta tagcacgttt gccaacttat
    17161 gtaaagcaaa agcacttgta cagcctaatt ttaggctatc tcttaaaatt ctgcctcaac
    17221 tcggtagata acttgcccct tgtttgagaa tttttgctcg tattctgtca tgacattgcc
    17281 ttcaaaatca ctggcatgca aatctagcca gacaccattg agtttcatgc catattgaga
    17341 aaagctcact aaactgtact caaacaagcc acggttatcc gtcttgaaat gaatttctcc
    17401 attttcaggc aagatacgtt tgaaggtgtc caaaaaggtc ttgtaggtca aacgacgctt
    17461 ttcatggcgt tttttcggcc atggatctga aaagttcaga tacaagcgat caatctcacc
    17521 gtcttcaaag tagtcagtca agtcagaacc atctacccac aagagcttga tgttaggcac
    17581 tccaacttca agcaccttgt ccaaagcgta gctcaaaaca gacttttgaa tatcaatccc
    17641 gatatagttg atgtcagggt tttgcttggc catacctgaa acaaaggcac cctttccact
    17701 tccaacttcc acatgaatgg gattatcatt gccaaacaag tcccgccatt ttgccttggc
    17761 ttccaaggga ttgaggacca catactgggg atttgcctct agtaattctg ttgccccttt
    17821 acgatttcta actctcatct tctctttcca tacttgtctc ggaaatgacg caaaccatga
    17881 atctcccgat tgacattttc taaatcttgg ttcatataat acttggaaat ctgactcaaa
    17941 taagacaatt gaccatacca atacaattta cttaataccg tttgattgta cttgtaaccg
    18001 tagtaggtca accattcctt ccactgatgt tctgaaatat aatggcagag catatgggcc
    18061 acatcaaaca tgcgatcggt caagcgaacc gaatcccaat ctactaaata aatcaagcca
    18121 ctatctgtct caatccaatt actatgtcgt acatctccat ggacaatggt cgcatggtcc
    18181 tctctaaatc ctggaatagt ctgacgcaaa tcagccatca cttcactgat aaaatgattt
    18241 ttacgcaaag catctggagc cgtttcttgc caagactgta gtaaatctac aggtgtttcc
    18301 atggcatagc ccaaacgact caattgtgtc atcaacggac gtgagcgatg aagacgggtt
    18361 aaaatattga cgatttgctt acgattcata tcataggggg tcaatatctt gcctgtcaac
    18421 cattcttgag cacacatatc acgcccatct gccaaacgac gactccataa taattgtgga
    18481 gcaatttgtt ctctagctag accaggtagg attggagagg tgttcatttt tacaaagatg
    18541 cgcttcccat caggatagct acccatataa gccttgccac ttttcccagg tatgggagtc
    18601 agtgttagct cattatcacc caaatccatt tctttcctcc gtataaagtt tccttactat
    18661 tctactagtt tttggcctat tcgtcaacca ctctaacccg attctcaaag aaaagcctct
    18721 ggattggctt gggtatcatt atagcttgaa aaaggtaagc accgtcttct gcttaccttt
    18781 tcataatttt tataaataat ataggagtgg ccaactgttg taaaacatgt ggactagagt
    18841 agaaacccat aggttttggc tctttttata agcaaggccc agcaacaagc ccccaagtag
    18901 ataaaaaata aacgaaggga cattagaagg tccatgcatg aaagaaaaga gagaggaagt
    18961 tagcacaagc cctaaccaag aattgtcaaa aaacgcacct tgaagaagtc ctctgaaaat
    19021 gagttcctcc tggatggggc caaaaactga ggtagtcaaa atcaaagaca gggaaattcc
    19081 tctgctgact tccgccaagt gttggacccc tgagccagaa gaaacagcga agaaatgaat
    19141 ataaaccagc gtctcaagta cacttagaag aaagattaca atgaaaagca aaagttgttt
    19201 cttgcttaac atcccaaaag aaatcatttc aaactttcta gcataagcaa cactcagcga
    19261 ggttacaaga agacttacaa taatcaatgc agattcattt tgaaaaaaat ccccatggtt
    19321 aatcgtataa ggaactgtaa tgacaattat tagtactaaa aatccaaaac acaaggcatg
    19381 aaatttatca aaaaactcca taaaattatc ctcctcaaca aacagacttc ctacacgtca
    19441 ttctttagtt ctagcctttc caaaacaaac cattttatac tcttcgaaaa tcaaattcaa
    19501 accacgtcaa cgtcgccttg ccgtactcaa gtacagcctg cggctagttt cctagtttgc
    19561 tctttgattt tcattgagta ttagtaacca aaatccgacc acatagccag cccctatgaa
    19621 tatagccatt aaagctagca tggaatttag gaaattaaaa accaccgcag atacaaaggt
    19681 tagcacaaaa acattaaaag caatggtgtc agaagacaag actagaatat agggtgtcaa
    19741 ccgatctaaa gttttggaat ctaggaaaaa taagtgttta tacatgatga cctcctctat
    19801 ggctgaaaag caagcctttt gtttttttac cccaagaccc tatgtagaaa agtgagcaaa
    19861 aacgggaagg tcgctacaat attattgatc acatgcaccg cataggatgg ataaatactc
    19921 ttggtatagc gggtcaaacc ggcaaagatg attccaaatg ttgcaaagac gaaaatatct
    19981 aacaaactag gtaggcttga aaaatgagga agagcaaata aaatggacgg aagaaacaaa
    20041 tcaaggccaa atcgcgaatg cttaaagaag gcgtgttgca gtaatcccct ataaatcaac
    20101 tcttccatta gtggagtcaa gaaaaacagg gttacataga tacctagctc agcaaagttg
    20161 gtcccactat aaccgatcaa tacggcccaa ccttcagcag ttgactgaac atgtttagct
    20221 atctgaacgt taaaagagat ctggagcact agcactaata ctgtcaaaat cgaataccaa
    20281 agccattttt ttcttggaat gcgaaagaga taaccatggc ctgtcttaac cagaatccaa
    20341 atcatgactc cgctaaatag taaactcaag atattttgaa tccagacgaa attaccaatc
    20401 tgggaagaaa attgccaata attttggacg ataagcgtca gctgagaaag accaaatacg
    20461 aaaaataagt aagagaagac tgcacttatt ttgaatagaa gttgatactt tttcatagaa
    20521 atcctcccta ctatgatctc accttgtcag actctactgc tgtaagatta agaagacagt
    20581 ttgttttttt aaggctaacc tgactactag ataatagata cattaaggca ttaaagacaa
    20641 tgaaaatatg tccatagaat aaaatcaacc tcgcatccaa accaagataa agtttgatta
    20701 tcaaaaagat gagcaaaaga atttgaaacc ataaggtttt tccaaaaata aatttaaagc
    20761 gatttcgaat atctacttcc ttgattttta ccgccacccc tttattagca agaaggaaaa
    20821 ctcctacttc aaacaaacca ctgtaaagaa caagccaccc aatagatacg atagagattt
    20881 gtaaaaatgt ccctaaaaga atatccaaca cactactcaa gaaaataaca aaaaataatc
    20941 tgtatttcat attaaatacc tccattcatt tatttcacta acaatttaat agagccttct
    21001 actcaaatat cctgtcagaa aaggatagaa agctactttt tataatactt caagccccac
    21061 atgagcagaa gcgtgataaa caagcagaga atacacctat ataagcgatt agttgttgat
    21121 agaattctgt ttctgaaata cctctataca aacaaatgac aaacataaaa tctgccaagc
    21181 cgataaacat aagttgattg gttctaggac taaccaaatc atcatttact tatatttaag
    21241 agtatctctt ttatgttaat gtatgttagc actgaaaagc aagacaggcc aataatattt
    21301 aaaatgaaca gtaacggggt taagtctcta aaaaaattat ctactgacac tacaagaaat
    21361 actatacata ttatagtcga aactatcttt ttcttatcca taattattta ctcctttcct
    21421 aacaaatcca gcttatcaat caagagcgat ttttaacata atgtagcagc acccgttgca
    21481 actttgacaa gtttagtata tcattgtttt ttaaaatttt tcatccaaat cttgaattgt
    21541 catcgaaaca tcttgaattg ttaaaaaatt taaaaagtaa gcattaaaaa catactttcc
    21601 tctttatatt gtattgatac caacttgttt gtagactttt catcctgcta tcacatatca
    21661 ttttgacagg cgaaacaata ttaaagaaac tcccctgtaa attaagctag caaatacagg
    21721 ggagaaattt attttttaga gagtactatc cgtatccttt ttggaagatt ttgaaaatat
    21781 ttttctaatt aagtcatcca tataaggacc aaatatacca actactaaac caataataaa
    21841 acttttaaaa tccataatta ccaccaacat gttgctacat aggctacacc tccaagtata
    21901 gctccacctg cagcaccagt tacacctatt cctatagcaa atggtcccaa tagaaatgtc
    21961 aaaccgttgt tgcacaccca tcaattgcgc catatgcaac ccctgctgca caactaattt
    22021 ttcttcccca atcaatatct ccaccttcaa cgcaagcaag catttcatta tccataacag
    22081 aaaattgtga catcattttt gtattcatat agtatgtcac ttttcagtta cggaacaagt
    22141 ttaatataaa aattatcaaa aaaacatagg caataaagag aaaaattaat ttatcgtaga
    22201 ttagaaataa tatgacaaaa caattcaatg atgttaattc aatagtcttt tgttttttat
    22261 cagagatact tatggataga taaataagat aggtttgaaa agcgaagaga ataataaaga
    22321 atatagcctt cataaaattt agctttcatt tttatgatgt agcggtatag gctaaatatc
    22381 cacaaaccac tgctcctcca attcctccta ttgcagcgcc ccatggtcct agaagtctcc
    22441 catatttcac tccacccgct gcacaaccta aagcagcaac tacagctgct cctccggaat
    22501 tacctccata aacctcactc agcattgttt catttatatt acaataagta ttcatacaag
    22561 tctcctttta ttaaaatcca cccgttgccc ctgttactcc tgcccaaaga tccacaccaa
    22621 atttagctcc tatgtatcca catgctccca taaatggtgc tccaacacca ctcgcagcac
    22681 aaatagctgt tcctagcccc cagccaccaa aagcagcacc accaccttct aagacattag
    22741 tttgccaatt attcttgcct ccttcaatac tagataacat agttatatcc atttcatgaa
    22801 attgttccat aatttttgta tccatgacaa atactctttt ttatttttaa tttttgtctt
    22861 gttgtaactt tgacaagttt agtatatcat cgttttttaa aatttttcat ccagatcttg
    22921 aatagtcatc gaaacgtctt gaattgcaaa aattacatta gacttcctgc aaaactagaa
    22981 tcctagttca tgattgataa taccagcaat caaatttatt cgtaatccga agcgtttacg
    23041 atgatttcga taggttgttg aaatcatttt aaacgttttt actttggcaa agatgttctc
    23101 aaccttgctt ctatccttag atagcgcatg gttacaggct ttatcttcaa ctgttagtgg
    23161 cttgagtttg ctggatttac gtggagtttg tacttgagga tatatcttca tgagtcctta
    23221 ataaccactg tcagccaaga ttttaccagc ttgtccgata tttctgcgac tcattttgaa
    23281 caacttcata tcatgacaat agttcacagc gatatccaaa gaaataattc tcccttgact
    23341 tgtgacaatc gcctgagcct tcatagcgtg aaatttcttt ttaccagaat cattcgctaa
    23401 ttcttttttt agggcgattg atttgtactt ccgtcgcatc aatcattacc gtgtcctcag
    23461 aactgagagg agttcttgaa atcgtaacac cactttgaac aagagttact tcaacccacc
    23521 ggctccgacg gataaagttg ctttcgtgga taccaaaatc agccgcaatt tgttcataag
    23581 ttcgatattc tcgcacatat tgaagagtgg ccataagaag gtcttctagg cttaatttag
    23641 gttttcgtcc accttttgcg tgtttaagtt gataagctgt ttttaataca gctaacatct
    23701 cttcaaaagt ggtacgctga acaccaacaa ggagcttaaa tcgtgcatca gttagttgtt
    23761 tacttgcttc ataattcata gaactatagt aaaatgaaat aagaacagga taaatcgatc
    23821 aggacagtca aatcgatttc taacaatgtt ttagaagtag aggcgtacta ttctagtttc
    23881 aatatactat accatatttt gtttcgcagg gaatctatta taaaagggta agtattgcaa
    23941 aaacacttac ccttttcttt tatacttcat taagctctac tttttataat acttcaagcc
    24001 ccacatgagc agaagcatga tgattaagca gagaacagcg ccaatataag cgattagttg
    24061 ttgataagat tctcctgctg tgatacctct atacaaacaa ataatagaca taaaacctgt
    24121 caagccgata aacataagtt gattggttct aggactaacc aaatcatcat cttcaaactc
    24181 tcttatcctc atttccctag tgagataaac agtaaccaaa atagaagcca agttaataac
    24241 tactaaaaga aattggaaaa ctacggaaaa atttaaaaac tgacgagata gaaatagata
    24301 agtagaaaca agcaagggca actgacctaa gaacaatctc gcaaggaaga tgttccgttt
    24361 tttagcaaga aaagttttca tttcttttct cctttctttt tattgatagc aaaatagatc
    24421 ataactgcaa tcacataggc tatggtataa aatagctgat accaagcact ctccctaagc
    24481 ggatatagaa agatggacat gattagatac agaacgaaaa taatcagtat ttttttcttc
    24541 ataagatttc ctcctaaatg tgcgatttat cttagttgag caagaacatt tacactgcta
    24601 gtatagcact tattttgacc ttggatcact caaatcataa atggtcatca aaacctcttg
    24661 aattgtaaaa attaaaaaag caagcatgaa aaacatactt tcctctttat attgtattga
    24721 taccaacttg tttgcagact tttcatcctg ctatcacata tcattttgac aggcgaaaca
    24781 aaattaaaga aactcccctg taaattaagc tagcaaatac aggggagaaa tttatttttt
    24841 agggggtact atctgtatcc tttttgggaa attttgaaaa tatttttcta attaaattat
    24901 ccatataagg accaaatata ccaactacta aaccaataat aaaactttta aaatccataa
    24961 ttaccaccaa catgttgctg cataggctac acctccaagt atagctccac ccgcagcacc
    25021 agttgctgca ccttgccatg ttcctgtttt aatgcctagt tgaagacctc ttgctgctgc
    25081 tcctccaaca cctgctttgg caaaatctcc ccaattgcat ccgccacctt caacgcaagc
    25141 aagcatttca gtatccataa cagaaaattg tgacatcatt tttgtatcca tgacaaatac
    25201 tcctttttta aaaaactaaa ataaatcaga atagaatcct cataatttta ctataagtct
    25261 taccaactta gtcccaattt atcaccaacc atacctccta agcatgttaa tccaccccca
    25321 attgcaccaa tgtgtgctcc aacaaatgca ccagcaagtc cagctactcc taaagtggcc
    25381 aaacctgctc cagttccacc agttataatt cccgtagtga ctcctgtaat cagtgcattt
    25441 tgacaatcag tggagctata ccccccttca actttcgcaa gcatttcagt atccataacc
    25501 tctaactgtg acaacatttt tgtattcatg atgaatacct cctttttatt ttcaatttgt
    25561 taccaaagtc ttaaattcaa taaacaaata gattttttat agtatctttt tgattttctt
    25621 aaaaaagtat acacgtctac tatcttctta aaggtagcag tacctatttt ttagtctaag
    25681 atttcaataa tcttgagtat ctaaaatatc ttaatttcgt tattctcctt gcaataaaaa
    25741 gttttactat actatttatt aacttgcaga aagcaaaaaa tattagtaaa taatagttta
    25801 tagttaagtt ttttattcct accaatccat caactaagta aagcatcaac gattacataa
    25861 acgattgata atataattaa aattttgcta actatcttat tctcatcatt cttagataac
    25921 tttgatattt tgtaagtaag taaataagac agtaaattaa tagcgataat aatactatat
    25981 ttaagaatca taatcttaca aagaggacat aattcctgaa cctacacaaa taagtgttgc
    26041 tgctccccca gttatcggac cagtcgcagc agctaatagt actgctccaa tacaaccacc
    26101 gattgcagat cctaaattgc ctcttcctcc actaactatt tcgagttctt cattatccat
    26161 aacagaaaat tgttccatca tttttgtatt catgacaaat actccttttt tcttttttta
    26221 tttttgtctt gttgtaactt tgataagttt agtatatcat cgttttttaa aatttttcat
    26281 ccagatcttg aattgtcatc gaaacgtctt gaattagctt ttttatttca agccacctct
    26341 aaatgtttaa aaaaaataat ttctaatcac ttttttacca ttcaggaagt tttaatgact
    26401 attcaagatt tcataaaata tgaacttagt tttatgacat aatagaccta tccactatat
    26461 gaaaggaatt gccaatgact tcttataaac gtacatttgt tcctcaaata gatgcgagag
    26521 actgtggtgt cgctgcctta gcctcgattg ctaaattcta tggttcagat ttttctctag
    26581 ctcacttgag agaacttgca aagaccaata aagaagggac gactgctctt ggcattgtaa
    26641 aagccgctga tgaaatgggc tttgaaacaa gacctgttca agcagataaa acgctctttg
    26701 acatgagtga tgtcccctat ccatttatcg ttcacgttaa caaagaagga aaactccaac
    26761 attactatgt tgtctatcaa acaaagaaag actatctgat tattggtgat cctgaccctt
    26821 ctgtaaaaat cactaaaatg tcaaaagaac gctttttcta tgaatggact ggagtagcta
    26881 tttttctagc taccaaaccc agctatcaac cccataaaga taaaaagaat ggtctactaa
    26941 gcaagcttcc ttcctctgat tttcaaacaa aaatctctca ttgcttacat tgttctctca
    27001 agcttattgg tcactattat caatataggt ggttcttact atctccaagg aatcttagat
    27061 gaatacatcc caaatcagat gaaatcaact ttaggaatca tctcagttgg tctggttatc
    27121 acctatatcc tccaacaagt catgagcttc tccagagatt atctcctaac cgttctgagc
    27181 cagagattaa gcattgatgt gattttatcc tatattcgcc atatttttga acttcccatg
    27241 tctttctttg cgacacgtcg tacaggagaa atcatttcac ggttcacaga tgctaactct
    27301 attatagatg ccttggcttc taccattctt tctctttttc tggatgtttc tattctgatt
    27361 cttgtagggg gagtcttgct ggcacaaaac cctaatctct tcctcctttc tcttctttcc
    27421 attcctatat acatgttcat catcttttct tttatgaaac ctttcgaaaa aatgaaccat
    27481 gatgtcatgc aaagtaattc tatggttagc tctgccatta tcgaagatat caacgggatt
    27541 gaaactataa agtcgctcac gagtgaagaa aatcgctatc aaaatataga cagcgaattt
    27601 gtagattatt tggaaaaatc ctttaagctc agtaaatatt ctattttaca aacgagttta
    27661 aagcagggaa caaaattagt tctgaatatc cttatcctat ggtttggcgc tcaattagtc
    27721 atgtcaagta aaatttctat cggtcagctg attaccttta acacactttt ttcttacttt
    27781 acaactccta tggaaaatat tatcaacctc caaaccaaac tccaatctgc gaaggtcgct
    27841 aataaccgtt tgaacgaagt ctatctagtc gaatctgaat ttcaagttca agaaaaccct
    27901 gttcattcac attttttgat gggcgatatt gaatttgatg acctttctta taagtatggt
    27961 tttggacgag ataccttaac agatattaat ctcacgatta aacaaggaga taaggttagc
    28021 ctagttggag ttagtggttc tggtaaaaca actttagcca aaatgattgt caatttcttt
    28081 gaaccctaca aagggcatat ttccatcaat catcaggata ttaaaaacat tgataaaaaa
    28141 gtcttgcgcc gtcatattaa ttacctaccc caacaagcct atatctttaa tggctctatt
    28201 ttggaaaact taaccttggg cggtaatcat atgattagtc aagaagatat tctaaaagct
    28261 tgtgaagtag ctgaaatccg tcaagacatt gaaagaatgc ctatgggcta tcaaactcag
    28321 ctctctgatg gagctggtct atcaggagga cagaagcaac gaatcgctct cgctcgtgct
    28381 cttttaacta aatctcctgt tttaatacta gatgaagcta ctagcggtct tgatgtcttg
    28441 actgagaaaa aagttataga taatcttatg tccctaactg ataaaaccat tctctttgta
    28501 gcccatcgtc tcagtatagc cgaacgaacc aaccgtgtca ttgttcttga ccaggggaaa
    28561 atcattgaag ttggtagcca ccaagagtta atgcaggcgc aaggtttcta ccatcatcta
    28621 ttcaataaat aaggagaatg tcatgaatcc taatcttttt agaagcgtcg agttttatca
    28681 gagacgttac cataactatg cgacagtgtt aattatacct ctttcattac tatttacttt
    28741 catcttgatt ttctcccttg ttgccacaaa agaaattact gtcacttccc aaggagaaat
    28801 cgcccctaca agtgtcattt catctattca gtcaaccagt gataatccta tccttgctaa
    28861 tcatttagtg gcaaatcaag tagttgaaaa aggggactta ctcatcaaat actctgaaac
    28921 aatggaagaa agtcagaaaa ctgccttagc aactcaatta caaagacttg agaagcaaaa
    28981 agaaggactt ggaattttga aacaaagctt agaaaaagcg actgatcttt tttctggcga
    29041 ggatgaattt ggctaccata atacctttat gaattttact aaacaatccc atgatattga
    29101 actgggtatc acaaagacta acactgaggt ttcaaatcaa gctaatcttg ccaatagcag
    29161 ttcatcagct attgaacaag aaattacaaa agttcaacaa caaattggag aatatcaaga
    29221 gctgagagat gctatcataa ataacagagc acgcttacca actagcaatc cacaccagtc
    29281 aattttgaat cgttatcttg tagcctcaca aggacaaaca caaggaacgg cagaggagcc
    29341 atttttatct caaattaatc aaagtattgc aggtcttgaa tcatctatcg caagcctcaa
    29401 aattcagcaa gctggtatcg gaagtgtagc aacttatgat aatagtttag caaccaaaat
    29461 tgaagtactc cgcactcagt ttttacaaac agcctcacag caacaactaa ccgtggagaa
    29521 ccaattaaca gaattaaaag tacaactaga tcaagcgaca cagcgcttag aaaacaatac
    29581 cttaaccgct ccaagtaaag gtatcgttca tctgaacagc gaatttgaag gtgaaaatag
    29641 aattccaact ggtacagaaa ttgctcaagt attccctatc atcacagata caagagaagt
    29701 actaatcact tactacgtag cttctgacta tctacctcta ctagataaag gacaaactgt
    29761 aagattaaaa ctggagaaga ttggaaatca cggcattacc atcatcggcc aacttcagac
    29821 aattgatcaa actcctacca gaacagagca aggcaatctc tttaaattaa ccgctcttgc
    29881 aaaactatct aatgaggata gtaaactcat ccaatatggc ttacaaggtc gcgtcactag
    29941 tgtaactgca aagaaaacat attttgatta tttcaaagat aaaattttaa cccattctga
    30001 ttaattttca gataacactc tataactatt tattatctta tcaaaaagga gaatcataac
    30061 atggataaga aacaaaacct aacttcattt caagaactaa caactaccga actcaaccaa
    30121 attacaggtg gaggatggtg ggaagaactc ttacatgaaa caattttaag taaatttaaa
    30181 atcacaaaag cacttgaact acctattcag ctataaaaac aagaccgaga aacaagtact
    30241 ctcggtctta tttttcatca ttctgtatgt atcacagtaa gtacctgacg aaagacttga
    30301 ttttgacagg tggtatttag actggtatta ggatggcttt ccacaatctt catgacggta
    30361 tagagaccaa ctcctctctc ctccccttta gaactggctc caaaggagaa gatttcagaa
    30421 atatcgatgc cctcttcttt gatggagttt tcgatgataa aggtctcctg tgctccattt
    30481 tttaaaaagg cgattgaaac atgaggttga ctagcttcca cactggcttc aatagcattg
    30541 tcacaaagga tagacacaat ggttagaaaa tcaagtagac tcatcccctc gacctgaatc
    30601 tcctcaggaa cttcgacatt aaagacaatg ttcttatctc tggcttttaa aaatttccct
    30661 gctagaagac ttttgaaggc tttatcacga atatttacca atctgcccag gtcatattta
    30721 ttgttctgca atttctgact ggaatccttt aagacggagc catagacctc ttttatctgc
    30781 tccatatcct cctcttcaat gcccagacgt aagctagtca agaggttggt ataatcatgg
    30841 cgaaaactcc gtacttcctt gtaaagctcc tctatatgcc gactatagcg ttccatatct
    30901 ctatagcgca gggcctgctc ttgttccaat ctctcataga gtttttcctt caaataggta
    30961 tccaatttct tgataacccc cataaaaaag agtaggtaaa agactaggat gagatggcga
    31021 acagtctttg attgaatact ttgttcatat tcaaaaaaag acagactttc catgactaga
    31081 tagtagccac ccattatcca gttaatctga gtcagggact tttgaaaggc tttatcgaga
    31141 atctcctttc tcaagctagt aaaatcgtag tccaaccatt tcaaaaaagc tagagaaatg
    31201 aagaaattga aaattattat acataaccca gtaaatgagt agccatcata tacttgccct
    31261 tgtcccaaaa atggaagcac aaaataggag actcctctat aaaagagatt caccaatatc
    31321 attggaaaga gaccataaaa gaaaaggagt tttttaggaa gccctctcaa taataagaaa
    31381 gataagccta tgccgtacaa gggttccata aaataagata ggtaaacatt tcctactata
    31441 tagctaatca tcacaaaaac aaaggccaac agtatcttaa aaagaaaggc cttaaaaatc
    31501 ctctcgaaag taagatcaat tccatccacc ttaaagaaga tgacaatttc tagtccatta
    31561 gtaacaagtg tatacaacaa tatccaagca atgttcataa attctcctag ctcagtgtaa
    31621 tttattgatg gcctcagaca cttccctgac cttataacgg gcgattagac aacttccacc
    31681 attgggaaag aaaagcagtt tttctttctt atccaaatgc accacatttg caggattgat
    31741 gagaaaagag cggtggcact gcaagagacg gggctcctgc ttgaaaacct cctctaaact
    31801 cgctgtaaat tccagcctgt ctgtcttggt atagagaata acacgatggg ctctgggcga
    31861 cgtttcgaga tagtaaacct ctttaaaagg atactgaaat tgggcaaatt ttgatttaaa
    31921 gtaaaagcaa tcttccgcca gacttttact atcttgacta ttggcataga ggagggctgt
    31981 ctcgatccga gattcaaact cctctgctga caaggcctta tcaatgtagt ccaaagcaga
    32041 cacttggtag cgaaaagaca ggggcataaa ctccgagtga gtcgtcacaa agacaatcag
    32101 ggcataagga tcccgatccc gaatctttct agccacttcc agtcccttca tctcttcatt
    32161 tcgaatctca atatccaaaa agaatagctg atgggccccc ttctcatgca cttcagccag
    32221 cagttggtcc ggcttgccaa atacctcaaa agagctagga atgatatgat gtgctttcaa
    32281 aagtttctca atcgtcgttt caattctagt ctgttgggaa aaatcatcct ctaaaacaaa
    32341 tattctcatc ttcttactct ccctctttca accatttttg acgaatttct ctatagcgac
    32401 gtctggcata cttgacagcg tattgacctt cttctccgag aaaaaggatt ctttcttgaa
    32461 aatcaatcga ttttaattta tcaagattaa ccaaacaatt tcgatgacat ctcatcaagg
    32521 tttccccaca ttggttctca agattactta aattttgaag catattaaaa ctagcttttt
    32581 ctgtaacaat ctgtacggta tgggctttag ttggatgtgt ttggatatag tagatatcgt
    32641 cgacgtttac tttatagact gttttctgcg tctgaataat catatgtttc attggattct
    32701 cctcctaaga aaagaataac agaaaagttc tagcccaagc ccacccaatc ctaaacagtc
    32761 tttgaaagct cctaaaagga ttatttttct acaacatcat gatgagctta caactatttt
    32821 atcataaaat tcactcagcg caattcaaga catttcaatg acaattaaag atttgaataa
    32881 aaaaaaagaa ttaaaagtga taaactaaca gtatcaaaac acagttgcca gaagtaagac
    32941 tggcacccag attaaaggag gcattcccat gacagataca gaccccatca aaagagctca
    33001 tactttgatt actgacttaa acaaagccta ccaagcatgc aaacaggcaa gtgctgacga
    33061 cgtccgcttt caggagcaat taaactctat tcttggtttt ctagccaagg ctgaaacagt
    33121 ggataatcga ttcttgattg aactagaaaa attttaccag acttccagtc ttctcatggg
    33181 actcagcgct cttgatccag atgctccaac tcgcgccgct tggcgggcct atgaccgctt
    33241 ccactttgac caagtcaaga ccaagttaat actcaatgaa aatcaaagag caaactagga
    33301 agctagccgc aagctgtact tgagtacggt aaggtgacgc tgacgtggtt tgaagagatt
    33361 ttcgaagagt ataagtctct acggaccaac cattatcctg tagtaacaaa aaagaagctg
    33421 agacagactg aactcaactt cttttttagt gtcgtatcag caatgttagt cctgcatctg
    33481 acgttttacc tgataaggca aatacaagac tagtaaaacc aaaccagctc ctagtaaggc
    33541 tagaagggcc agtttttctt ggaaggtaat caacccaaca actaattcca caagtaaaac
    33601 aaaactggtc aatcctcgaa ctacctcctg taagcctttt tccttttgcc ccttgtccag
    33661 tggaaagagt tgggtcaaat actggtagtc aaaggcatga tagagggcca gcaactgaaa
    33721 gagcaagagg tagttaaaga gaaccaccac tgctgtcgca atccaagctt gctcgataaa
    33781 aacctgcgcc agtacggaaa gtaagagaag acgaagactg agagcaaaga ggtcgccatt
    33841 tcgcagataa gaacgcagat agagattttg ccaaatcttc ccaggcacct tctgaacagc
    33901 ctttaagata aagtccagat aggcacgacg cttgacactg tttgaaattc ccttgacctg
    33961 cgtaaagagg gcaaagaaac gaagcaagac ttgcttacgc ttgctttctt gagaaataag
    34021 atagtcccag tccagtccag tttcagtgaa aaatttgctg gccttttgac gaaagtggaa
    34081 atattttcct acccccaata aaagcacata gagcagaaaa actggcaagc cataacccat
    34141 tgctaaaaac aagggcgcaa ataacagcaa gaaaagggtc tgtacaaaga gccaaaagac
    34201 tagggaaatg ccagtttgac gcttgagatg gagcttgatt tcctcttctc caactaagag
    34261 aaagagcttg tctggagcct ccatataggt ggcaattcct ccccaaagta aaagtaaaac
    34321 agacgtaatt cctacaaaca aaagaatagg ccaatgattt tcaggaaaat gttgtaagag
    34381 ttgactgtac tggtaggcta gaaagcccaa caggacaagc aggaataaga caaagtggtc
    34441 attgagcaca tagcgcagat aaccaagaca ctccttacga aaggcctgct ttctctttaa
    34501 aaacaagtct ttcataggtc ctcctctttt gtcagagcca agtaaatatc attcaaacta
    34561 gcctcaggca tatcaaaggc ttcgcgtagt tgcaggagat tgcctttggc acgcacctct
    34621 cccttgtgaa gaatgacaaa ggcatcacac atcttctccg ccgaatccag cacgtgggta
    34681 ctcatgagaa tagacttgcc cttttgcttc tccacttcca aaagctgaat caaatcagaa
    34741 atagccagcg gatcaagacc aaggaaaggc tcatccacga tgaaaagact tggatccacc
    34801 acaaaagcac agataatcat gaccttctgc ttcatccctt ttgaaaaatg aacagggaac
    34861 cagtctaatt tctgttccag acggagcatc tttaacaagg gctctactcg ttcgaaagcc
    34921 actttttgct caataccata agccatagca accgtttcga tatgctctct gagggtcaat
    34981 tcctcataca gactaggcgt ctcaggaatg tagccaatct gcttgcggta gctagtcgca
    35041 tctccttgca gagtcaggcc attgatattg atggagccac tataaggtgc caacagaccg
    35101 ataatctcat tgatcgtcgt tgatttccca gcaccattga gaccaatcaa accgaccaac
    35161 tgcccacttt caacagtaaa ggacacatct ttcaaaacag gaacatgaac atagccacct
    35221 gtcaggtttt taatttctaa catattttct ccaaatctgg tataatgtag ctatattata
    35281 tcaaaattca atacagcaga ggtagatttt atgtcagatt gcattttttg taaaatcatc
    35341 gcaggggaaa ttcctgcttc aaaagtatat gaagatgagc aggtccttgc ctttcttgat
    35401 atctctcaag taacactagg acacaccttg gtcgtgccaa aagaacacta tcgcaatctt
    35461 ttggagatgg atgctacgag cgccagccaa ctctttgccc aagtaccaaa agtagctcaa
    35521 aaagtcatga aagtcactaa ggctgctggt atgaatatca tttccaactg tgaagaagtc
    35581 gctggtcaaa cagtttttca tactcacgtt caccttgtgc ctcgctacag tgctgacgat
    35641 gacctcaaga ttgattttat cgcccacgaa ccagactttg acaaacttgc tcaaatcgct
    35701 gaaaccatca aaaacgctta aggagttgct atgaaattat ccaacctact gctatttgca
    35761 ggagctgcag ccggaagtta tctggttaca aaaaatcgcc aaaccatcac agatgaagtc
    35821 ttgaatacca ctgaccgcgt tcaagctatc aaggacgatg tggatattat ccaaaacagc
    35881 ctgcaaatca ttaaccagca aaaagaactt atcaaggaat accaagaaga cttgacttac
    35941 aagtttaagg tcttggaaaa ggatatccag actagactag ctgtgataaa agaaatgcag
    36001 ggaactgaag ataagtaaaa agagcccccc ggctcttttt taaaacgtaa acaagttata
    36061 gtgaattgaa tttagaatag cacaccatag tttctaaagc attgttagag attactttaa
    36121 aatcctctta tcaatttgtt catattctat ttcaatctat tatatatatc ccatcaacta
    36181 tgcatcataa tttaggtaac tcatactcaa taaaaatcaa aaagcaaact agaaagctag
    36241 gcacagactg ctcaaaacac cgttttaagg ttgtggatag aactgacgaa gtcagctcaa
    36301 aacactgttt tgaggttgtg gatagaactg acgaagtcag taaccatacc catggcaagc
    36361 cgacgctgac gtggtttgaa gagattttcg aagagtatta ttcaccattt cacaactaaa
    36421 tcgaagactt tctgccgtaa tgaaaacacc tgaaacagct tggtttcagc tgtccggaaa
    36481 ctttaaaact taggttcaaa gtttaggtat ggaacttcga aggaggtcac taccgtccgt
    36541 cattacttag gaaagtctta aaaaatctat aaagtaaaaa gagcccgaca gctctttttg
    36601 tttatactca atgaaaatca aaaagcaaac taggaaacta gccacgggct gctcaaaaca
    36661 ctgttttgag gttgtagata cgactgacga agtcagtcac atatatacga caagccgacg
    36721 ctgacgtggt ttgaagaaat ttttgaagag tattattctc catcaaaggc atctttaata
    36781 tggtcaaaga agcctttttt ctttggattt actttcaagt caccagcagc cgcgaattct
    36841 ttcaaggcta ctttttggcg gtcgttcaag cctgtcggtg ttacgacatt aacagtaacg
    36901 tattggtcac caactgcacc gccacgaagg ctcggtgccc ccttaccacg taggcggaat
    36961 ttcttaccag tctgagttcc ctctggaata accaattcaa catcaccgtg aacagttgga
    37021 atatctactg tatcaccaag agccgcttgg acaaagttga ggttgagatt gtagaagata
    37081 gtcgttcctt cacgttcaaa cttgtcgcta gcttctacag aaactactac atacaagtcc
    37141 ccataaggtc caccgttaaa gcctgcttcg ccttgaccag cgaggcgaat ttgttgacct
    37201 gtttccacac cagcagggat tttcacatgt acgctatgag cttgtttctc atggcctgtt
    37261 ccatgacagg ttgtacatgg atatttgatt tcttttcctc gaccgtgaca gacatcacag
    37321 gttacttggc gacgcatcat accaagagga gtctgcgtat cgacgttaat gacaccagcg
    37381 ccatgacagc gtccacaagt gactggactt gtccctggct tagcaccaga gccattacat
    37441 gtacgacagc cagcttcacg atgatactta acttccttct cagttccgaa gatagcttct
    37501 tcaaaggtca aattgacacg atactggaga tcatctcctt ggcgaggagc gtttggattg
    37561 cgcgaagaac cgcctccgcc gaagaaactt gagaaaatat cctcaaaacc accgaagcca
    37621 cctgccccat tgaaaccacc gaaaccacca gctccaccaa aaccaccatt ggcgcctgca
    37681 gcaccatact ggtcataggc agcacgtttt tggtcgtcac tcaaagtctc ataggcttct
    37741 tgaacttcct tgtacttgtc ctcagcacca ggctccttgt tgatatctgg gtgatatttt
    37801 ttggaaagct tacgataagc ctttttgatt tcgtctgccg aagcgttttt ggataccccc
    37861 agacgatcat aaaattcagt attgttcata attcaagata caaagggcgt caaacggaca
    37921 cagccatcta ggagttttga cgacggacgc ttacgtccta gaaaaaacta tctttttggc
    37981 acagtccgta gcccgtgttc agttacgaac acccttattc ctttctattg atgttctgaa
    38041 tcgaaccacc atttaggtcg ggttcaattc ctttctttta tatttagtaa gaaattctga
    38101 aacccgtgtt cagttacgaa cactctttgt tcctttctat tgatgagaca aaacccaaac
    38161 aaatgagatt ccgtcccttt ttatcgaaaa acagaggctg ggttgcaacc tctgcaaata
    38221 agtaaattaa ctttattttg attttaaata tcctataagt acagaaatat ttatatattt
    38281 ttgtctcttc ttagtatttg cctatataat tccaattgat cataagaaat acaactactg
    38341 tccaaatcat accaattatg aacggtatta caaatttata tgtttgtatt tctaatgata
    38401 tcatagctga taccatcgcc gatacaaatg cagacaacaa tactgaggta acaaaattcc
    38461 ttaccgcttc atcatttttg acacaactat catgctcagc taatataatt tctctatatc
    38521 tagctaaata ttctattgga atattatcaa taaaatcttt tgatgttcta tagttatcag
    38581 cttgattaca aaaatcatta taaacttttc gtgtattttt tagatactct tcatccaata
    38641 cactcatctt acttttccgt aaactctccg tctacgacgt catcgcctgc gtttcctgtt
    38701 gcttgtgcgc cttctgctcc ttcttgagct tgttgcgctg ctgcggcttg ttcgtagagt
    38761 ttaacagcaa gtccttgagc tttttcgttc aatgcttcaa gttttgcttt catgtcgtcc
    38821 aagttgttgt cttcttgagc tttcttaagg tcatcaaggg cagcttgggc agcgtcacgt
    38881 tctgcgtcga agcctttacc ttcagtttcc ttgattgtct tttcagtcgc aaagattgct
    38941 tggtccactt cattacgaag gtctacttct tctttacgtt tcttatcgga ttcagcgttt
    39001 gcttctgcat ctttcatcat gcggtcgatt tcttcgtcag tcaaacctga gttcgattgg
    39061 atgacaatag tttgttcttt ttgagttcca aggtctttgg ccttaacaga cacgataccg
    39121 ttcttgtcga tgtcaaatgt tacttcgatt tgaggaattc cacgaggtgc agctgggata
    39181 tcagtcaatt ggaagcgtcc aagagtcttg ttatctgctg ccattgggcg ttcaccttga
    39241 agaacgtgga tatcaacggc tggttggttg tctgctgctg ttgagaagac ttgtgattta
    39301 gatgttggga ttgtagtgtt gcgatcgata agttttgtaa atactccacc cattgtttcg
    39361 ataccaagtg acaatggcgt tacatcaaga aggacaacat ccttgacatc accagtaatc
    39421 acaccacctt ggatagccgc acccatagca actacttcat cagggtttac tgatttgttt
    39481 ggttctttac cagtttcagc tttaacagct tcaacaacgg cagggatacg agttgaacca
    39541 ccaacaagga taacttcgtc gatttctgac aagctcaaac ctgcatctga aagggcttga
    39601 cgaactggaa cttttgtacg ttcaacaagg tcacgagtca aatcatcaaa tttcgcacga
    39661 gttaaagtca tttccaagtg aagaggtcca gcctcacctg cagtgataaa tggcaagctg
    39721 atttgtgttg aagttacacc agaaaggtct ttcttcgctt tttcagccgc atctttcaaa
    39781 cgttgcattg ccatcttgtc agtagacaag tcgataccgt tttctttctt gaattctgct
    39841 accaagtggt caatgatttt ttggtcaaag tcgtcaccac caagtttgtt gtcccctgca
    39901 gttgacaata cgtcgaagac accgtcaccc aattcaagga tagagacgtc gaatgtacca
    39961 ccaccaaggt caaataccaa gattttttct tctttgtcag tcttgtccaa accataagca
    40021 agagctgctg cagttggttc gttaacaata cgttctactt caagaccagc aattttacca
    40081 gcgtcttttg ttgcttgacg ttgagcgtcg ttgaagtaag ccggaactgt gataacagct
    40141 ttggttactt tctcaccaag gtagtcttca gcgtagcctt tcaagtattg aaggatcata
    40201 gctgagattt cttgtggagt gtattctttt ccatttgcag aaactttttc agaagttccc
    40261 atcttagatt tgatagagat aactgtatct gggtttgtga ctgcttgacg ttttgcagca
    40321 tcaccaacga tgatttctcc gtttttgaat gagactacag atggagttgt gcggtttcct
    40381 tctgggtttg cgatgatttt gctttcagtt ccttcaagaa ctgcaactgc tgagtttgtt
    40441 gtacctaagt caataccgat aattttagac atgtgttttt ctccttgtta gttaattttc
    40501 tatttttctt tttgatactc ttcttaagtg gcgacagtgg cgacgccgtc agagcttgac
    40561 ttcgtcagtc tctttgacta aactttgagc ctaaggtctc aaaatttgcg caaatagcgc
    40621 cacggcgaag agtatcgtct ttggttcgct tcgctcacta ttacaaagca aaacatattt
    40681 tatctttctt catagtttat tgtcgtttcg gacaagtttt ctattatgta aattgcgaca
    40741 cgagaagtcg aaatcgattt tatttcgacg acgagttagt aaggaagcta ggcaaacgcc
    40801 atagcaattg ccgttttctg acgagttgct ttagctaccg tcagaattgc cgaatcgaac
    40861 acgccctaag ctctgagtaa aaaagataga ttttcttgtg ttcatcgaac acttcgttaa
    40921 tctcctattt ttactgcgag ctttttacgg gctttgtatc ttagttatac accactacca
    40981 ttgctgggcg taggatgcgg tcatggagtt tgtagccttt ttgaaagact tgggcgatgg
    41041 tatctactgg gtgttcatcg tctgctggga gagtttggat ggccatatgg tagttatggt
    41101 caaattcgcc atctgctgcg atttcttcaa ttccttcttc tttcaaagcg tgaatcaagc
    41161 tttcttgcac catccccaag cccttcttca catcatctgt caaaccttca actgcaagtg
    41221 cacgctcaag gttgtcaaga gatggtaaga ttgcttttgc caagtcctgg ctacgataac
    41281 gttgcaagtt ttgacgttct tcattggcac ggcgttggat attttgcatt tctgcatgag
    41341 cgcgaagata tttgttttcg aactcatctg cacgttcatt tgccaagtcc aactcagact
    41401 tttcaggagt tgtttcttca gctgtttcca caacttcctc ttcttgaact tcttctactt
    41461 cttcattttt tatatcttgg gccatgttcg cctcctttaa tgatttcaat cttaatgtac
    41521 ttcgtaatga ttactgctga ggtagcggta aaaatctgtc aacttcatgg tcaaaacacg
    41581 gttgaccaca ttgatttgat tgattagctg ttggtaatcc agattaactg gaccgataat
    41641 ggctagaatt ccaactcccc gataaggaat gaggaactta ctactaatca ccgctaggtc
    41701 agctaaacag gactcttgac cgtctgcaac acgaacattt tgcatctgat cctcacgcaa
    41761 cccctcacga atctccaagg ccaccttttg cggttggtca aagaactgat aggctgctag
    41821 attggcaaaa ttcaagagat tgaccttgcc cgccatcaca atgttttcgt tgaacatttc
    41881 cttaaagatg tgttcaaaga gatcgatgac attatccgtt gttgtaaagt aacgctggat
    41941 aatctgcgga atctccgtcc gaatcttgta gtgaatatct aaaacggtgt gaccgaggaa
    42001 acgttcctga atgatgctct tcagtttcag caaatcctcc tgcaagaagt tccttggaat
    42061 cagaaactga ctagtaaccg ttcgcgactc gtctagggta aataccgcca aggctgtatg
    42121 ttgccccaaa acaacgatat caaaggctgt caaacgttgc ctgctcggct caacatccag
    42181 tgccactacc gtacagccac tcaggtctgt tagcaagtta gcagcctctt gcagaatatc
    42241 ctccaatttg aagaattcct gatcaaaggc tttgacaatc tcatatacct cattttcagc
    42301 cagtcggtca aaatccagtg agtgtttcac atagtactga aaaccagcaa cacttggcat
    42361 ccgaccgctt gaagtatgag ccttctcaag caacccttgt ttttctagtt ccgccatgtc
    42421 attacgaatg gttgcactgc tagagttaat agactcttgc aaggcttttg atccgacagg
    42481 ttcgtgcgtt ttggtaaaga tgtcaataat cagatttaaa atatcctgct gacgctctgt
    42541 aaccatctca tcactcctct ctgtctgatc aattagcact caatgcatcc aagtgctaac
    42601 ttatgattct attatacacc cttagaagag aatgtcaaga caaaaactca aaaaattagc
    42661 actcttttat aaagagtgct aaaaatcaat ctgaagacct agaaccttgc tattcatcta
    42721 ctcggtattt cctttttagt ctgaaataac catgaattag ataagaaatc agaaaagcat
    42781 ataaaacaaa aataagaaag aaagacatag aaagatcctc tctaaacaaa ctcatacaaa
    42841 caacaagacc acctaagaaa gtagctatac aggaacgaag tctagatcgc ataacttccc
    42901 atttgagccc cttactcata tagacttgat cctctggaag taaatcagaa gacgatttac
    42961 gaagaatcga acaagaacct gctcctatca attcccaacc tctatctcta aaatcttgca
    43021 gttcacgctt atgctcttta agaaatctag aatcatagat acgatagata acatcgtccg
    43081 gttgaccttg ctcaaaatag aacaaaccaa aacgactagt tctatacctc caacctttca
    43141 aatgcatctc atgtaaatat tcttctttct tgtccaaatc aacaatggtg aaaatccgaa
    43201 attctactct gctattcatt gtcttacccc aaaattagaa aacatgccta gcgttattta
    43261 ttagataatt ctttccactt ttgactcaat ctccaaaaaa tataagaaat ctgaatcgca
    43321 aaaactatca ataaaaccca atctattatg aaaatcaaaa acacttccca actgaaagaa
    43381 ctacctccag tgacaaactt tgagaaaaac ggtagtagag ctaaaaagag aagcaaaata
    43441 ggaagcatcc gcattgttaa aatccgtttg gcataaaaaa tctttattta aacgaaaata
    43501 ttatggtaaa atttacgcca gtttttgaac ggctgatgta gatattttat actttcaaaa
    43561 tgtttaaatg tgattattta tttttgaaaa atagctcacc agcccgactg aaagtgctta
    43621 taaatgataa taagtcgcct gccgaaaaca gcgaaaaata gcggtgttat gcggagataa
    43681 tctgacgcga tgcgaaagta tattgcatac ttattttcaa caatttagca gagtattttt
    43741 ataagtgtga tataatagaa gtataatttg ttctgatagt ttatttatgg agaagtagat
    43801 ttttagaatg cggagggttc aatatggttg agtttataaa gtctaagaaa gaaatgagtg
    43861 aggaggatat taaagcaaat ttcatcactc ctgctattgt atccaaagga tggaaaaatg
    43921 gtgagcatat cgcttacgaa gaatacttca ctgatggtcg aattgaggtt agaggagata
    43981 aggctcgtcg taaagaagga aaaaaatcag actattcact gtattaccaa tttggaactc
    44041 gaattgcaat tgttgaggca aaggataata aacacagcgt tcgagcagga ttacaacaag
    44101 ctattgaata tggagagatt ttagatgttc catttgttta ttcttcgaat ggtgatggct
    44161 ttattgaaca cgaccgtatc acgagagaag aacgtgagct ggagttagac gaattcccta
    44221 ctcgtgaaga attattttct cgtatgacga aggaaaaagg attgacgtac gaaattacag
    44281 aagctatctc aactccatac tatacagacg ccttctcaat gaaaacgcca cgctattatc
    44341 agcaaatagc tatcaaccgt actattgaaa cagttgccag aggacaaaaa cgagtaatgt
    44401 ttgtgatggc aacaggaacg gggaaaacgt tcatggcttt tcaaattatt catcgccttc
    44461 gaaaagctgg tttggctaaa cgagttttat tcttagcgga tagaaacatc ttagtagacc
    44521 aaacgatggc tgaagacttt aggccattcg aaaaggtaat gacgaaaatt acaccaaaac
    44581 ttttgactgc tcctgaaaaa ttaaattctt ttgaaattta tctagggctt tatcagcaac
    44641 taactggtga agatggaact gaaacacatt atcaaaaatt tgacaaagac ttctttgatt
    44701 taatcgtaat tgatgaagcg caccgtggtt cagctaagga agacagtaac tggcgtaagg
    44761 tgattgatta tttcagttct gcgacacaga ttgggatgac cgctactcct aaagaaacca
    44821 agaatgcttc caatacggaa tactttggtg agccaatcta tacttatagt ttaaaacagg
    44881 gaatcgagga tggttttttg gctccatatc gtgttatgag ggttaattta gatgtggatg
    44941 tggatggtta tcgtccagaa actggaaaag ttgatactaa cggacaatta atagaagata
    45001 ggtactacgg caggaaagat tttgataaaa ccattgtcat tgatgataga acgcaaagag
    45061 ttgccaagtt tgtttctgat tatatgaagc aaaacaatgc acgatttgat aaaacaattg
    45121 ttttttgtgt tgatattgac catgccgagc gaatgcgtgc tgcacttgta aaagagaatc
    45181 tagacttagt ccaagaagac tatcgttatg tcatgcaagt aactggtgac aacgctgaag
    45241 gaaaagctca actggataac tttatggatg tcaattctaa ttttcccgct attgtaacaa
    45301 cgtctaaatt attaacgaca ggagttaatg ctaaaacatg tcgtttgatt gttttagact
    45361 ctaatatcca atccatgact gaatttaaac aaattattgg tcgtggcaca cgtctttatc
    45421 ctcaaaaggg gaaagaattt tttacgatta ttgattttcg aaatgttacc aatttgtttg
    45481 ctgaccctga ttttgatggt gagccagtga aggtgctgga aacaggtgcg aaaacagtca
    45541 gtggttccac gcccggtttc gtagatgagg aaggtgaccc agtagaaaaa tatatcgtta
    45601 cagacaagca ggttaccatt cttaattcta ctgttcaagt attggatgaa aacgggaaac
    45661 tgattaccga aagcctgacc gactacactc ggaagaatat cttaggtagc tacgccactt
    45721 tgaacgattt tatcacagtt tggcatacgg cggataaaaa gaagcttatc ttagacgaac
    45781 tttataaaaa aggagtttat ctagatgcta ttcgagagtc ggagggaata tcagaacaag
    45841 aaatcgatga ttttgattta ctcctaaaac ttgcctatgg tcaaaaagaa ttaaccaaaa
    45901 cggaacgtat caataaactc aaacaaagcg gatatttata taaatatagt gaggaagcgc
    45961 gtgctgtttt ggaaatttta ctgaacaaat acatggataa aggtattgga gaactcgaaa
    46021 gcattgaaac attaaaactt ccagaatttc agatatatgg tggaaccttc aaaatcatca
    46081 atacttattt tggagataaa aaacgatatt tacaagcaat taaagaattg gagcaagagc
    46141 tatttacagt agcttaatga aaggaaagta tgtcaattac atcatttgta aaaagaattc
    46201 aagatatcac tcgaaacgat gctggtgtta atggtgatgc tcaacgtatt gagcaaatgt
    46261 cttggttatt attcttaaaa atttatgata gccgtgaaat ggtttgggaa ttagaagaag
    46321 acgagtatga gtcaattatc ccagaggaat taaaatggcg aaattgggct catgctcaaa
    46381 atggggaacg ggtattgaca ggcgatgaat tacttgattt tgtcaataac aagttattca
    46441 aagagttgaa agagcttgaa ataacttcaa atatgcctat tcgaaaaacg attgttaaat
    46501 cagcttttga agatgcgaac aactatatga aaaatggcgt cttgttacgc caagtcatca
    46561 atgttattga tgaagttgat ttcaatagcc ctgaagatcg tcattcgttt aatgatattt
    46621 acgaaaaaat tcttaaagat attcaaaatg ctgggaactc aggagaattt tatacgccac
    46681 gtgcagcgac tgattttatt gccgaagttc ttgacccaaa acttggagaa tcaatggcag
    46741 accttgcttg cggaacagga ggcttcttga cttcgactct gaaccgttta agtagtcaac
    46801 gtaaaactag tgaagatacc aaaaaatata atacagctgt ttttggtatt gaaaagaaag
    46861 catttcctca tcttttagca gttacaaatc tgtttcttca cgaaattgat gaccctaaaa
    46921 ttgttcatgg aaatactttg gagaaaaatg ttcgtgaata tacggatgat gaaaaatttg
    46981 acattattat gatgaatcca ccttttggag gatcagaatt agaaacaata aaaaataact
    47041 ttccagcaga attacggagt tctgaaacag ctgatttatt tatggctgtc attatgtatc
    47101 gtttaaaaga aaatggtcgt gttggagtta ttttacctga tggttttcta tttggtgaag
    47161 gtgtaaaaac tcgcttgaaa caaaaactgg tagatgagtt caacttgcat acgattatta
    47221 ggttgcctca tagtgtcttt gcaccgtata caggaatcca tacgaacatt cttttctttg
    47281 ataaaacaaa gaaaacagaa gaaacttggt tttatcgttt agatatgcca gatggttata
    47341 aaaatttctc gaaaactaag ccgatgaagt cagaacactt caatcctgtt cgtgactggt
    47401 gggaaaatcg tgaagagatt ctggaaggta agttctacaa atctaaatca tttacaccta
    47461 gtgaattggc tgagttgaat tataatttag accagtgtgg ctttccaaaa gaggaagagg
    47521 aaatcttaaa tccctttgag ttgattcaga attatcaagc ggaaagagca actttaaatc
    47581 ataagattga taatgtatta gctgatattt tgcagttgtt ggaggacaaa taatgacacc
    47641 agaacaactt aaagcaagta ttctccaaag agcgatggaa gggaaattag tgccgcaaaa
    47701 tcccaatgac gaacctgcaa gtgaattatt aaagagaatt aaagctgaaa aagaaaaact
    47761 tatcagtgaa ggaaaaatca aacgagataa aaaggaaact gagatatttc gtggtgatga
    47821 tgggaaacat tatgggaagt ttgctgatgg aagtactcaa gaaattgatg ttccttatga
    47881 tattcctgat acttgggagt gggtgaggat aaaatcaatt tattggaatt ttgggcaaaa
    47941 taagccagag aaatccttta ggtatataga tacgtctagt attgatagaa aaaagaacat
    48001 aatcaactac aaaaatctac aatatctttc acctgaacaa gcgccttccc gtgctagaaa
    48061 attagtttcg cagaatagtg tcttattttc aacagttaga ccatatctaa aaaatattgc
    48121 tgtagttaga gaacttaaag agtatttgat agctagtaca gcatttattg ttttggatac
    48181 tttacttaac gaaacatatt tgaaatatta tttattatca gataatttta tcaatcgtgt
    48241 taataataaa tctactggaa caagttatcc tgcaatcaat gattataatt ttaatctatt
    48301 attaattgct ctccccccac tatccgaaca acaacgaata gtagaagcaa tcgaatcagc
    48361 tttagaaaaa gtagatgaat atgctgaaag ttataataga ctagaacagc tagataaa
//
LOCUS       DAVLHC010000012        46158 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.012, whole genome shotgun sequence.
ACCESSION   DAVLHC010000012 DAVLHC010000000
VERSION     DAVLHC010000012.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 46158)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 46158)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..46158
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.012"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(<1..1608)
                     /locus_tag="VXE25_000719"
     CDS             complement(<1..1608)
                     /locus_tag="VXE25_000719"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000212172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771225.1"
                     /translation="MATLDELKVMIDAEIAPFRKKMKEVENQVKGTSDQVKNATAKVR
                     EQSNSIGSAFGKLAKFAGFAILGKKLLDVGMYSTQTALEVSASMNQIKRQMGESSQSF
                     LKWVNDNANAMNMGVGEATNYGAVYSNLFSGFIKDTNKLSAYTAKMLQTSAVVAEGSG
                     RTITDVMERIRSGLLGNTEAIEDLGINVNVAMIKSTEAFKKFANGQSWQQLDYQTQQQ
                     IRLMAILEQATAKYGNTLSNSVNGRISLFKSLMKDAALNLGNSMLPIINAIMPVLNSF
                     AMVLKNVTAKLAEFITLMFNKKATVKDGVGGAVGDMGNAMKDAAGGAGDLADAVDDAG
                     DSAGGLADNLGDSAKNAKKAAKELLGLLGFDEINILQKPKDDDAGGSGGGGKGGKGKG
                     GGGGPFKDILPEVELTDMDNKFKSIFDGLGDKLKGLFDLFKKGFDAAFRPEGIKRIKT
                     ALDQIAKTMGEIATDPRVVNAFNRMAEKIAYALGQVTGSIATIGLGIGVFLAESIANG
                     LGRQKERITRALVALFDNVGNLSEAVGN"
     gene            complement(1595..1945)
                     /locus_tag="VXE25_000720"
     CDS             complement(1595..1945)
                     /locus_tag="VXE25_000720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000478007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771226.1"
                     /translation="MFLDIGGKPLDFWDLTVLEIREMIESYNRVKIQERKEKIIDSYI
                     LSRMITNHVSLLLSNDAKIVELWEYAPELFVEEQQAVEQERQRQALLLHKERMRDFAE
                     RHNRKRKEEVNGNS"
     gene            complement(1984..2364)
                     /locus_tag="VXE25_000721"
     CDS             complement(1984..2364)
                     /locus_tag="VXE25_000721"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001185634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771227.1"
                     /translation="MALKYTTWKVTDEKELKLRLTSHQAATVEEKIGMNLLKIFMPEA
                     GEEFTLPPLKVMLLLVHGALQQYEHGYSFEDVYDLYDEYVDNGGDQTTFMTEVLMPLF
                     EVSGFTPRGSKDKKTSKKKMTVVE"
     gene            complement(2369..2782)
                     /locus_tag="VXE25_000722"
     CDS             complement(2369..2782)
                     /locus_tag="VXE25_000722"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000880678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HEV0771228.1"
                     /translation="MLANGIKLAFSETKGNYQNLVGLKEVPEFGIEPEKVENTTLADT
                     VKKYEFGIGDAGELEYKFAYNNSSATAPYRVLRKAADGKKKLYFEQTYPDGTKVTFEG
                     QVSVKLGGGGVNAVIEFTLKIALQSELTFVDGIGG"
     gene            complement(2785..3153)
                     /locus_tag="VXE25_000723"
     CDS             complement(2785..3153)
                     /locus_tag="VXE25_000723"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000608233.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771229.1"
                     /translation="MINIKPVIYKELQKVADNVTDTYPSDWETFPVVIFLEEQNKPGD
                     WFDDQEQKSSIRYKVDIFDDTSTSELAVKINQIFESLGLRRTDCQDVPDPSHLRHKVM
                     RFEGVVDLDSELVFQFRMEN"
     gene            complement(3150..3665)
                     /locus_tag="VXE25_000724"
     CDS             complement(3150..3665)
                     /locus_tag="VXE25_000724"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000015942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HK97 gp10 family phage protein"
                     /protein_id="HEV0771230.1"
                     /translation="MSGLLGADRLIAKCRRLASKKTGEDIVLRAVHNATIKVVQADAR
                     RLAPARDGELIISIKTRAKMDGDKAIGEVYTNLKYAPYVEFGTGPIGQANHSGISPEV
                     SVTYKSNPWYVHEDQINVGPYHFQKIGEFYKMYGQPAQPYLYPALRDNQERVSKNISN
                     YVRRKIREQIK"
     gene            complement(3640..3978)
                     /locus_tag="VXE25_000725"
     CDS             complement(3640..3978)
                     /locus_tag="VXE25_000725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000478943.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771231.1"
                     /translation="MFLKQSRLKPYPMRRFEKTVTEEGVAKEGYAKEAETVRLELWPA
                     SSKLQSELYGERVNDILNANANKSATIKVKDGVCIDSQTEVTHRVISKKVYTHHQVLE
                     LERVRATRGR"
     gene            complement(3959..4270)
                     /locus_tag="VXE25_000726"
     CDS             complement(3959..4270)
                     /locus_tag="VXE25_000726"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866508.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage head-tail adapter protein"
                     /protein_id="HEV0771232.1"
                     /translation="MSIELLKKLTGEEDTQLLMLFQTRATNLILSETNRTSLTPALSL
                     LIPEVAIELHNRSGAEGERSRTEGGIAVVYGENGLSTGLLQRIRMHRLARVAGHVFEA
                     E"
     gene            complement(4272..4460)
                     /locus_tag="VXE25_000727"
     CDS             complement(4272..4460)
                     /locus_tag="VXE25_000727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000669348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771233.1"
                     /translation="MKFKIKQDFYDWESNVKRLAGEELEITEERYAELADNIASNGVA
                     ISDVLEKILPEPEFLEED"
     gene            complement(4470..5495)
                     /locus_tag="VXE25_000728"
     CDS             complement(4470..5495)
                     /locus_tag="VXE25_000728"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397670.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar-binding protein"
                     /protein_id="HEV0771234.1"
                     /translation="MAFEELNTAESRKKHLGIIEDVLAVNSYSTPLVTSSDAVTLQGR
                     SFTVATGNTTELKDYKRNKDNEFDHVEVEEKVYTLDEEKYWGRFVDQLDERDSNGQVN
                     INYVIARQAAEVVAPYLDELRFSAALGNVSDNVTMGKEAGANNAYNAILDVSEKLDEL
                     GITKERLLFVTPKFYKAIKSEIVRLPHGDADKKVLGKGYVGELDDYTVYKVPSKFLKG
                     VNALATAPGVVTSPVQVDNTKYNDNIPGRFGELVEQLLYTGAFVLEHFKKYIITIADS
                     KPAAKKSAQGKTVNRAKAWKTGTAYKEGDTVTHEDKVYVAIKDITSSTNAPGSDSANW
                     KEKTGKK"
     gene            complement(5518..6042)
                     /locus_tag="VXE25_000729"
     CDS             complement(5518..6042)
                     /locus_tag="VXE25_000729"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001288018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4355 domain-containing protein"
                     /protein_id="HEV0771235.1"
                     /translation="MSEEINATVSTESTETVDTQGNVDSVQEEKHERTFTRAEIGKML
                     SAERSKWEAEQEAKENEAKKLAKMNADEKQKYQLDQREQELADREKAIARKELTAEAK
                     AMLSERDLPVELVNVVDLTNAETVSESITSIQKAWEESVQKGVSERMKGSAPIKNAQT
                     VQQEVTEKWRKDFL"
     gene            complement(6309..6482)
                     /locus_tag="VXE25_000730"
     CDS             complement(6309..6482)
                     /locus_tag="VXE25_000730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000379086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771236.1"
                     /translation="MDKAKIGITNVEFSGTGGIESATVKLELNIYGADTFSAIELLPK
                     ILTDIHSLSYEVD"
     gene            complement(6524..6937)
                     /locus_tag="VXE25_000731"
     CDS             complement(6524..6937)
                     /locus_tag="VXE25_000731"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565278.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HD domain-containing protein"
                     /protein_id="HEV0771237.1"
                     /translation="MIDIALAIAKKAHAGQVDKADVDYIQHPLYVASQVKTEQEKAVA
                     LLHDVIEDSDITAADLLASGLSNEVVTAVQILTKKKGQSYQEYLGKVKSNNLARVVKL
                     ADLKHNSDLSRLKSVTNTDYERVKKYKNAIYYLST"
     gene            complement(6934..7143)
                     /locus_tag="VXE25_000732"
     CDS             complement(6934..7143)
                     /locus_tag="VXE25_000732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000651745.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771238.1"
                     /translation="MKDIKYYRTTTNNAQVLRLIDGVMQVFDIEKKWVNSIDWFNKIF
                     FNDFTDFEEISENDAFTYIDRMVAA"
     gene            complement(7145..8782)
                     /locus_tag="VXE25_000733"
     CDS             complement(7145..8782)
                     /locus_tag="VXE25_000733"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000795722.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="minor capsid protein"
                     /protein_id="HEV0771239.1"
                     /translation="MKNQEYWAKRKANLIYQQMDKAEKQADQFDKVYQEAKTYLDKEV
                     NKIFDKFQRDYGLSQVEARQVLKNMKDKKNLNELRKVLEARPNDPNIQRLLADLDSPA
                     YSFRMKRLERLSDDLDRMRESIYHSEKTGSDAFYSDLMKDSYYKVTFDLQQQTGLAYG
                     FSGLPESEIKHLQSFSWVGDGSTYSTNIWKNTGKLTSSIKDELLISLMTGRDTRETAQ
                     AIAERFNVGQNDARRLVRTESAFFHNQMELLSYEEADIEKYIFVAVLDKRTSRICQEH
                     DNQVYDRDKAVPGVNCPPMHPWCRSTTVGYDEDADYSKLKRRARNPETGKVEYVPADM
                     TYKEWYSKYVAKDGEKVYNQDTREAKAKFYSEQLLSKISGVEPKITSDMQRIAGENKL
                     AGLEFRKKTVESLSRKIIADSLVENISLSKAVSKINDALRYTTIFDSDTFTEEYLKMK
                     QKLVAEGYKIVKVKNTWLVDGPYKGVNTVVEKDGINFEMQYHTQESFDLKNGSLHELY
                     EKYRDTNTSDLERMKLFKEMLDLSNGLEIPKNIERVK"
     gene            complement(8691..10160)
                     /locus_tag="VXE25_000734"
     CDS             complement(8691..10160)
                     /locus_tag="VXE25_000734"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399164.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage portal protein"
                     /protein_id="HEV0771240.1"
                     /translation="MYQYLTYPRDGYDEGSLKKDLIYKLITIHSTEGSHLKKLKSYYL
                     GEHAILKHTRRNVNAPNYKTVANHAKDIADTATGYFMGNPIKYNNTADGDIDELLTAF
                     DGAEIDQVDAQNALNMAIYGRAYEYIYAKEGMAELDSTSIDPENTFMVYDDSIERKPL
                     FAVYYYEVKDDTKDTTKYQAEVFTENLHYHMVLRSTDSGTTQSEEATPHNLGQIPIIE
                     YRNNHFAIGDYEQQISLIDAYNSLMGNRVNDKEQAVESILVLYGTQLADTPEDAKVAM
                     KILSEEGLLELPGDSARAEFLKNTLDESATEILRTALKEDIYTFSHVPNLTDENFAGN
                     TSGVAMEFKLMGLEMITKTKEANYKRGLRQRIAIFAHYLGMKQIALESHSIVPQFSRG
                     LPKNLLEISQIVNNLEGKVTNRQLISLLPFVEDPDAELEALEEEKKKNMEDMPMFNQD
                     NTKPEDEVEDEESGVLGEEESQSDLPADGQGRKAGRSVR"
     gene            complement(10172..11470)
                     /locus_tag="VXE25_000735"
     CDS             complement(10172..11470)
                     /locus_tag="VXE25_000735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000084419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PBSX family phage terminase large subunit"
                     /protein_id="HEV0771241.1"
                     /translation="MSQTYQIKQNDIVVDLPKTVGAGYGQFWRSRSLYRVVKGSRGSK
                     KSKTTALNYVVRLLKYSWANLLVIRRYSNTNKQSTYTDFKWACNVLGVTHLFKFNESL
                     PEITVKATGQKILFRGLDDELKITSITVDVGSLCWAWFEEAYQIETEDKFSTVVESIR
                     GSLDVPDFFKQITVTFNPWNERHWLKRVFFDEETSRADTFATTTTYKCNEWLDEVDIK
                     RYEDLYHTNPRRARIVCDGEWGVAEGLIYENVTVKDFNKDELLQDSANKLCIGLDFGF
                     THDPTALCCSLINDTTKEIYVFDEAYKVGLITKEVAKMIKDKGYHRSQIIADSAESRL
                     IEELRSEHGISRIKESRKGKDSIMAGVSKLQGYAIYVHPDCKNIMDEFYSYCYQRDKE
                     GNWLNKPEDKNNHLMDALRYSLQCIEGGKATVRRRSDYGL"
     gene            complement(11448..11888)
                     /locus_tag="VXE25_000736"
     CDS             complement(11448..11888)
                     /locus_tag="VXE25_000736"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="terminase small subunit"
                     /protein_id="HEV0771242.1"
                     /translation="MSGLRIKQKRFADEYIISGNATEAYKKAGYRVSSDRVAGVEGHK
                     LLKNPKIKSYIDERLKQLDSEKIADQQEVLGYLTSVMRGETQEQTLISIGELGQTITD
                     IDVGAKDRIKAAELLGKRHRLWTDKVEADVSGTVVFANESDIPD"
     gene            complement(12193..12275)
                     /locus_tag="VXE25_000737"
     tRNA            complement(12193..12275)
                     /locus_tag="VXE25_000737"
                     /product="tRNA-Tyr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(12242..12244),aa:Tyr,seq:gta)
     gene            complement(12356..12760)
                     /locus_tag="VXE25_000738"
     CDS             complement(12356..12760)
                     /locus_tag="VXE25_000738"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001030243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1492 domain-containing protein"
                     /protein_id="HEV0771243.1"
                     /translation="MNKAKELLKELQDLDMDIQSRIDEINELEAGLLSSPKWSEVKVQ
                     GGQTRKVDDVYTQLVVMKEAIEQDTKEVINRKLELGRMINRLKNPKYRAVLRMTYINK
                     GTADSVCYDLNMSRTTYYRLKNEAVLALEEVI"
     gene            complement(12833..13204)
                     /locus_tag="VXE25_000739"
     CDS             complement(12833..13204)
                     /locus_tag="VXE25_000739"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001247150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771244.1"
                     /translation="MRPCKYPYSGRRKKQETPSPIFSARPIFDEVPIVEEVKVEFGVE
                     ASMGRIYPETLIHLDISGYGNRVHSVHRFPGILLSVGESIQLKMLFYKRLRNFTTDRF
                     LTFRESDWKFFIRDLVNEFKH"
     gene            complement(13201..13638)
                     /locus_tag="VXE25_000740"
     CDS             complement(13201..13638)
                     /locus_tag="VXE25_000740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000612395.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771245.1"
                     /translation="MIPKFRVWVKIGKRMVFSDDILAIDYENKEIVTQQVYFENGLPD
                     DRDIYCYDFDEIELMQSTGLKDKNGKEIFEGDIVRTTRFLGRADEIGGFYEYDKEFIG
                     IVKQLEGSWVIDTGSDAVCLWTEIEENEIIGNIYENKEFGGRK"
     gene            complement(13635..14123)
                     /locus_tag="VXE25_000741"
     CDS             complement(13635..14123)
                     /locus_tag="VXE25_000741"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001102760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1642 domain-containing protein"
                     /protein_id="HEV0771246.1"
                     /translation="MNVQRLIEKYKKLEGVWDAEGAELARQIFLEDLKQLDEQKPVKV
                     PQCVAEYIEFKKKNNFHVYGAMRVIEDHYDKKVPDWFYENNIEKFCLAWLNGYEVEKE
                     KRYTVVMKETKQPLYYNAGDKRLFFSLGGIATKFTRKQLEDTGFGWVFDCEGIDIEEV
                     EE"
     gene            complement(14125..14442)
                     /locus_tag="VXE25_000742"
     CDS             complement(14125..14442)
                     /locus_tag="VXE25_000742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000969666.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771247.1"
                     /translation="MMEELKQKVNEVYNWTVEDGKPQPPKQDLPQAVKDRADYFWEMA
                     EDGMTFMGAMECIFADEKPTDYDLGATKDWLPKSKEFDDWVGYSPSMAQVVIAVYLIY
                     RGN"
     gene            complement(14467..14649)
                     /locus_tag="VXE25_000743"
     CDS             complement(14467..14649)
                     /locus_tag="VXE25_000743"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000796349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771248.1"
                     /translation="MADYALYQGDVFVTLGTLAQISSETGITERMLKYYTYTSHQRRH
                     PNGRAVIKIEEEDNEN"
     gene            complement(14665..15096)
                     /locus_tag="VXE25_000744"
     CDS             complement(14665..15096)
                     /locus_tag="VXE25_000744"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000779143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RusA family crossover junction
                     endodeoxyribonuclease"
                     /protein_id="HEV0771249.1"
                     /translation="MKLTLNIEPKPQSRPRFARRGSFTTTYEDKDMKTWRNHCQLLIA
                     NQYMGQPILEGALRTRLRFYIKPPQYISKVKKNQQALLDEIIPVGKKPDIDNYEKALY
                     DSMSGIVFQDDGQIALHDVGKFYSLNPRIEVEIEVMKSLSI"
     gene            complement(15093..15422)
                     /locus_tag="VXE25_000745"
     CDS             complement(15093..15422)
                     /locus_tag="VXE25_000745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771250.1"
                     /translation="MASKINATERIAIIIDKQKIEVVTTLNYDMSISFDNKDTAPTLD
                     DNGDLFEPVYKCRVKAIPKNDVFFTSLTRVKSNIKTLQEVKKFFEFVNENRENLFEMA
                     GFKGALE"
     gene            complement(15436..15645)
                     /locus_tag="VXE25_000746"
     CDS             complement(15436..15645)
                     /locus_tag="VXE25_000746"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866813.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771251.1"
                     /translation="MEWTDWVDWKPETKTDIKTKIENDGYTFPHYDKKNNGVKYVIST
                     LDIKRDCLRLGVPFEDVYPLQTTLF"
     gene            complement(15611..16117)
                     /locus_tag="VXE25_000747"
     CDS             complement(15611..16117)
                     /locus_tag="VXE25_000747"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000034833.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HEV0771252.1"
                     /translation="MSKIKILDACCGSRMFWFDKNESHTIFMDIRQETFEIHDKKVNV
                     DPDIIGDFRDMPFEDNTFNLVVFDPPHLKWAGPNSIMKAQYGQLDKVTWSEDLAKGFE
                     ECMRVLKVGGTLVFKWSDCQINVKKLLEVIPFKPLFGQQRGTTHWLTFVKFEEDKNGV
                     DGLGGLET"
     gene            complement(16127..16543)
                     /gene="ssb"
                     /locus_tag="VXE25_000748"
     CDS             complement(16127..16543)
                     /gene="ssb"
                     /locus_tag="VXE25_000748"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000609607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="HEV0771253.1"
                     /translation="MINNVTLVGRLVAPPDLRKTPNNVSSLQGTLAVNRNFKNENGER
                     EADFINFQAWRGTADIIAQYCSKGSLIGIIGRIQVRSYEKDGQRRYVTVVIAESVVLL
                     ESRNSQHGQGNSFQNGNSSPFTDPNPFDLPNDGLPF"
     gene            complement(16638..16973)
                     /locus_tag="VXE25_000749"
     CDS             complement(16638..16973)
                     /locus_tag="VXE25_000749"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000598346.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation protein Cse60"
                     /protein_id="HEV0771254.1"
                     /translation="MIKTVFFSCDYPHHEVIDDQINSWLAENPGIKLIDIKFQSNVSA
                     VADSGVSAEYWHTSALIIYKVPSENNISSINSNGLGFIISCEKCGSLSIIKGKDVGQN
                     VCYECKGEK"
     gene            complement(16966..17289)
                     /locus_tag="VXE25_000750"
     CDS             complement(16966..17289)
                     /locus_tag="VXE25_000750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000354630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771255.1"
                     /translation="MDIRKISDSVAIYSDGKKLQVIHNLGDEFILDFNVGEDSVWNLN
                     GQVVEIIDMIEPVFKVFSFCSKSGEGMQRLKHAIVHFEKFEQYIRDNQEDLMIWWHNP
                     GGEYD"
     gene            complement(17457..18521)
                     /locus_tag="VXE25_000751"
     CDS             complement(17457..18521)
                     /locus_tag="VXE25_000751"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001157031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1351 domain-containing protein"
                     /protein_id="HEV0771256.1"
                     /translation="MQELQVIDDKKINKIYEIITTDELTRESFEKDLIEATEKYKDYI
                     PTAGTLKDDKAKRAEFNKLIESKNRIRIDTKNLLSETANTWDSYAKSIIDPFATVVSE
                     FDKGIKEIEEHQRQLKIDTVKSYLANKSAEYMLDPRLFDEKALEYVKASDFMADGVTL
                     KKATMKSLDDMVTFEFQKQQEFEKAKSAISGLCAEYGMTDSPYIRQLKDLTLAEVFGQ
                     IKADYEFEKQKEEIRQAQERAERESQELLAAQQTKQQEQAPKSTETPNFDPETGKILD
                     GGQILQNEPNALRGAENDLKRYAQKMTLEVYFVDTAEKDCFKAGLSKLGFDFKKNYQV
                     SGYQRIDPLTQAELNEQCGW"
     gene            complement(18531..19283)
                     /gene="bet"
                     /locus_tag="VXE25_000752"
     CDS             complement(18531..19283)
                     /gene="bet"
                     /locus_tag="VXE25_000752"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage recombination protein Bet"
                     /protein_id="HEV0771257.1"
                     /translation="MTNNQLATQTKRNITTDPSLLTGADIKKYFDPQNLLTEKQVGQA
                     LALCKGRNLNPFANEVYIVAYTNRNGGKEFSLIVSKEAFLKRAAQCKDYEGFEAGVVA
                     VDSEGVMHERKGAIMLPGDTLIGGWARVHRKNFKVPVEIFVSREEYDKKQSTWNTMPA
                     TMIRKVALVNALREAFPEDLGNMYTEDDGGETFDRIKDVTPQESREDVVARKMAEIEQ
                     FNKEQEANHADPEPAQTEESIQGELLDGELEY"
     gene            complement(19301..19486)
                     /locus_tag="VXE25_000753"
     CDS             complement(19301..19486)
                     /locus_tag="VXE25_000753"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000746960.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771258.1"
                     /translation="MKKRLYYKKWKQELREAMREEIDGDYLTEKMVRKMSISDMSHYL
                     NRLALEEAGYCGTMFNY"
     gene            complement(19791..20045)
                     /locus_tag="VXE25_000754"
     CDS             complement(19791..20045)
                     /locus_tag="VXE25_000754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771259.1"
                     /translation="MFKALKTIKKIKQLQKEMHDASVAVLLMQDLGLVPDSEKGRTRA
                     KSFHDVSHMLKDVLGGKSVDEAMKRLNSEVKIEDVEQEDD"
     gene            complement(20058..20312)
                     /locus_tag="VXE25_000755"
     CDS             complement(20058..20312)
                     /locus_tag="VXE25_000755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000275521.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771260.1"
                     /translation="MYIISIYVKNTETGNEDFSLIGRDFLPTGHQDYIARVFETKEEA
                     IDYLKSISYIASGLHGNDWVYQNEKLPEIESRCRIWKVGE"
     gene            complement(20325..20534)
                     /locus_tag="VXE25_000756"
     CDS             complement(20325..20534)
                     /locus_tag="VXE25_000756"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000771947.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771261.1"
                     /translation="MKLLTKLKLRLEGVLKSVNLDWREVAVELMTDLFEERKRRFAFE
                     QENYDLKQELAAYKYKENFDIKARL"
     gene            complement(20534..20695)
                     /locus_tag="VXE25_000757"
     CDS             complement(20534..20695)
                     /locus_tag="VXE25_000757"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000859599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771262.1"
                     /translation="MKTVKKEWEPRIVNIMADGSQVDDLTGYVIPAGHSYYDIILGMN
                     KQSNEEGVA"
     gene            complement(20767..21492)
                     /locus_tag="VXE25_000758"
     CDS             complement(20767..21492)
                     /locus_tag="VXE25_000758"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001004151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage antirepressor KilAC domain-containing
                     protein"
                     /protein_id="HEV0771263.1"
                     /translation="MNELINVTLNDNHEPVVSGRQLHEALGVKTKYADWFNRMIEYGF
                     TENQDFLLLKNEQQTGRGGHNKVDHIIKLDMAKEIAMIQRTERGKQVRQYFIQVEKDF
                     NSPEKIMARALLMADQKVHKLEAQIEADRPKVLFADAVSASHTSILVGELAKLISQNG
                     YKIGANRLFSWMRENGYLIKRKGSDWNVPTQRSMDLKLFEIMETNVQHADGHITVNKT
                     PKVTGKGQQYFINKFLNQEYLTG"
     gene            complement(21516..21719)
                     /locus_tag="VXE25_000759"
     CDS             complement(21516..21719)
                     /locus_tag="VXE25_000759"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001247546.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771264.1"
                     /translation="MRPRRYPYSGKKESTFVKADPELVEKLLRNTSFLERLQKKPINF
                     QIDSEEFKRLSYEAIHDTSQVTQ"
     gene            complement(21908..22186)
                     /locus_tag="VXE25_000760"
     CDS             complement(21908..22186)
                     /locus_tag="VXE25_000760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000261154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HTH domain-containing protein"
                     /protein_id="HEV0771265.1"
                     /translation="MVVLSNKENWLVYPEEIARRLNISREMVLRHFKKIEKAGYLRTV
                     KKSLGRGRGVQTFRFFSDTKITDFQFEIMLQRLDEAIAMKKSELSTIT"
     gene            complement(22353..22589)
                     /locus_tag="VXE25_000761"
     CDS             complement(22353..22589)
                     /locus_tag="VXE25_000761"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001157069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE family transcriptional regulator"
                     /protein_id="HEV0771266.1"
                     /translation="MQELTKKQKLKKQELKPKIKLRKERKKHELTTVFMADLIGLKNR
                     RQYELKENGKAPFHDYEISIISNYFHKSESELFF"
     gene            complement(22642..22803)
                     /locus_tag="VXE25_000762"
     CDS             complement(22642..22803)
                     /locus_tag="VXE25_000762"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001247368.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771267.1"
                     /translation="MRPIGYRLNVEVSGIEELKEACKEVSKKAEELQEAIDRLSIIEF
                     ELKAKPVND"
     gene            22850..23656
                     /locus_tag="VXE25_000763"
     CDS             22850..23656
                     /locus_tag="VXE25_000763"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003052452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR02391 family protein"
                     /protein_id="HEV0771268.1"
                     /translation="MLSIDTQFVDTISKILSDYVSHSEITRMGEVLGYPQNDQNSGLN
                     KHHRVHNIMSDILNKTQDKSNIKLVIEYICNPLRYIDTVSDFENLRLKLNVVLSLKGL
                     TISDDGHVVITTASQTLVEAKKRFESLEHMLRTLNVHPNVLKFCTQELLQENYFHAVF
                     EASKGIFHRIRLLTGSSLDSASLIDQCFKTKEPIMIINGNKLQTLDEQSEYKGLKNLL
                     LTIAHLYRNSKAHKLKYYNPDSVHDALTALTLMSLAHNLLDNCTNTRRLD"
     gene            complement(23591..23884)
                     /locus_tag="VXE25_000764"
     CDS             complement(23591..23884)
                     /locus_tag="VXE25_000764"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009853499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771269.1"
                     /translation="MEKLAEVTQEETEKILTYDEIVLLKPITHLHKSIFRQTEYLSEQ
                     LTERLHHLEDYNSPIDEETIRLAEVTIEFYNLLIKSPSISAVVKEIVSEGHKS"
     gene            24129..24806
                     /locus_tag="VXE25_000765"
     CDS             24129..24806
                     /locus_tag="VXE25_000765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018165612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4145 domain-containing protein"
                     /protein_id="HEV0771270.1"
                     /translation="MRIEVKTDSNFKQEVFVDNICPNCSKPTNPQVVSQGYNEIMPGK
                     DSIYVTLRCLGCYHYWVEEFVRELDRGGFYDTTHIKVKTQLPSDIPISNDLELISPVG
                     KEIYVQSLKAEQEHLDLIAGIGYRKALEFFVKDFSILTNPDKKEKITNMLLKQVIEDY
                     IEDEDLKTFALASTYIGNDEGHYYRKNPDKNLADLKKYIHGVIYYLEKRLIFLDAQEL
                     VNRSTKS"
     gene            complement(24965..25240)
                     /locus_tag="VXE25_000766"
     CDS             complement(24965..25240)
                     /locus_tag="VXE25_000766"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015973618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771271.1"
                     /translation="MNTLNEKAINIFKAVAKETLIQGTYEENFLYSQLEAFCTNCRQF
                     AFGWTELAEEIERQERYLLDSGFTQEEIDDIRFDAAFAGMLDKLNVA"
     gene            25401..26138
                     /locus_tag="VXE25_000767"
     CDS             25401..26138
                     /locus_tag="VXE25_000767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEV0771272.1"
                     /translation="MNILGSSIKEVRKSKKLTQKKLAELTGFKQNTISNHENGNRQLD
                     EKDIRIYAQALEVSPQYLFDLAKPSSIEIIPTTSPIQTIYDELEPPRQGKVLNYAKRQ
                     LKEQRNEEETKINEVSEAIRLYSYDYYDHPASAGTGQYLNDVRVERIELPVDVDADFV
                     IPIKGDSMEPDYHDGDLVFIQTSVDLNDGVIGVFNYNGDAYIKQLVIDEDQAYLHSLN
                     PEYKDMPITPDTDFRIIGEVVDLYREK"
     gene            26140..26340
                     /locus_tag="VXE25_000768"
     CDS             26140..26340
                     /locus_tag="VXE25_000768"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000064302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771273.1"
                     /translation="MSNESRPMEVIKHNLDCKCHRRREWIRVNDKWHAIEFSVDDPNE
                     PPMTEEEKANVALILQQHLSKE"
     gene            26520..27965
                     /locus_tag="VXE25_000769"
     CDS             26520..27965
                     /locus_tag="VXE25_000769"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HEV0771274.1"
                     /translation="MITTNKVAIYVRVSTTNQVEEGYSIDEQKDKLSSYCDIKDWNVY
                     KVYTDGGFSGSNTDRPALESLIKDAKKRKFDTVLVYKLDRLSRSQKDTLHLIEDVFIK
                     NGIEFLSLQENFDTSTPFGKAMIGLLSVFAQLEREQIKERMQLGKLGRAKSGKSMMWA
                     KTSYGYDYHKETGTVTINPAQALAIKFIFESYLRGRSITKLRDDLNEKYPKHVPWSYR
                     AVRTILDNPVYCGFNQYKGEIYPGNHEPIISKEEYDKTQSELKIRQRTAAENVNPRPF
                     QAKYILSGIAQCGYCGAPLKIMLGVKRKDGSRLKKYECHQRHPRTLRGVTTYNDNKKC
                     DSGFYYKDKLEASVLKEISKLQDDADYLDKIFSGDNAETIDRESYKKQIEELSKKLSR
                     LNDLYIDDRITLEELQSKSAEFISMRGTLETELENDPALRKNKRKADMRKLLNAEKVF
                     SMDYENQKVLVRRLINKVKVTAEDIVINWKI"
     gene            complement(27983..28045)
                     /locus_tag="VXE25_000770"
                     /pseudo
     CDS             complement(27983..28045)
                     /locus_tag="VXE25_000770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000738626.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein ComGC"
     gene            complement(28047..29063)
                     /locus_tag="VXE25_000771"
     CDS             complement(28047..29063)
                     /locus_tag="VXE25_000771"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000355375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II secretion system F family protein"
                     /protein_id="HEV0771275.1"
                     /translation="MDISQVFRLRRKKLATAKQKNIITLFNNLFSSGFHLVETISFLD
                     RSALLDKQCVTQMRVGLSQGKSFSEMMKSLGCSSAIVTQLSLAEVHGNLHLSLGKIEE
                     YLDNLAKVKKKLIEVATYPLILLFFLLLIMLGLRNYLLPQLDSSNIATRIIGNLPQIF
                     LGMVGLVSVLALLALTFYKRSSKMSVFSILARLPFIGIFVQTYLTAYYAREWGNMISQ
                     GMELTQIFQMMQEQGSQLFKEIGQDLAQTLKNGREFSQTIGTYPFFRKELSLIIEYGE
                     VKSKLGSELEIYAEKTWEAFFTRVNRTMNLVQPLVFIFVALIIVLLYAAMLMPMYQNM
                     EVNF"
     gene            complement(29011..29952)
                     /locus_tag="VXE25_000772"
     CDS             complement(29011..29952)
                     /locus_tag="VXE25_000772"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000249584.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II/IV secretion system protein"
                     /protein_id="HEV0771276.1"
                     /translation="MVQEIAQEIIRSAREKGTQDIYFVPKLDAYELHMRVGDERCKIG
                     SYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYAYDQKMASLRLSTVGDYRGHESL
                     VIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQ
                     VMSIEDPVEIKQDDMLQLQLNEAIGLTYGNLIKLSLRHRPDLLIIGEIRDSETARAVV
                     RASLTGATVFSTIHAKSIRGVYERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFAS
                     RDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS"
     gene            complement(30028..30393)
                     /locus_tag="VXE25_000773"
     CDS             complement(30028..30393)
                     /locus_tag="VXE25_000773"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1033 family protein"
                     /protein_id="HEV0771277.1"
                     /translation="MYRVIEMYGDFEPWWFLEGWEEDIVASRKFDQYYDALKYYKTCW
                     FRLEQESPLYKSRSDLMTIFWDPEDQRWCDECDEYLQQYHSLALLQDEQVIPDEKLRS
                     GYEKQTSQERNRSCRMKLK"
     gene            complement(30544..31602)
                     /locus_tag="VXE25_000774"
     CDS             complement(30544..31602)
                     /locus_tag="VXE25_000774"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-dependent alcohol dehydrogenase family
                     protein"
                     /protein_id="HEV0771278.1"
                     /translation="MKAYTYVKPGLASFVDVDKPVIRKPTDAIVRIVKTTICGTDLHI
                     IKGDVPTCQSGTILGHEGIGIVEEVGEGVSNFKKGDKVLISCVCACGKCYYCKKGIYA
                     HCEDEGGWIFGHLIDGMQAEYLRVPHADNTLYHTPEDLSDEALVMLSDILPTGYEIGV
                     LKGKVEPGCSVAIIGSGPVGLAALLTAQFYSPAKLIMVDLDDNRLETALSFGATHKVN
                     SSDPEKAIKEIYDLTDGRGVDVAIEAVGIPATFDFCQKIIGVDGTVANCGVHGKPVEF
                     DLDKLWIRNINVTTGLVSTNTTPQLLKALESHKIEPEKLVTHYFKLSEIEKAYEVFSK
                     AADHHAIKVIIENDISEA"
     gene            complement(31765..32916)
                     /gene="nagA"
                     /locus_tag="VXE25_000775"
     CDS             complement(31765..32916)
                     /gene="nagA"
                     /locus_tag="VXE25_000775"
                     /EC_number="3.5.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylglucosamine-6-phosphate deacetylase"
                     /protein_id="HEV0771279.1"
                     /translation="MPNYIKADQFFYPHGVRRGGYLELVDGKFGKHVEQIPEGAEVID
                     YTGYSIAPGLVDTHIHGYAGVDVMDNNIEGTLHTMSEGLLSTGVTSFLPTTLTATYEQ
                     LLAVTENLGNHYKEATGAKIRGIYYEGPYFTETFKGAQNPTYMRDPGVEEFHSWQKAA
                     NGLLNKIALAPERDGVEDFVRTVTGEGVTVALGHSNATFDEAKKAVDAGASVWVHAYN
                     GMRGLTHRELGMVGAMYQLPHTYAELICDGHHVDPKACEILIKQKGTENIALITDCMT
                     AGGLEDGDYMLGEFPVVVANGTARLKSTGNLAGSILKLKDGLKNVVEWGIANPHEAVM
                     MASFNPAKSVHIDDVCGQIREGYDADFIVLDKDLELVATYLDGVKRYQA"
     gene            complement(33069..34886)
                     /locus_tag="VXE25_000776"
     CDS             complement(33069..34886)
                     /locus_tag="VXE25_000776"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001220923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyltransferase"
                     /protein_id="HEV0771280.1"
                     /translation="MRIKWFSLIRIIGLLLVLLYHFFQTIFPGGFFGVDVFFTFSGFL
                     ITALLIEEFSKNNEIDLIGFFRRRFYRIVPPVVLMVLVTMPFTFLVRQDYVAGIGGQI
                     AGVLGFMTNFYELLTGGSYESQFIPHLFVHNWSLAVEVHYYILWGLAVWFLSKQAKSN
                     GQLKGMIFLLSATAFLISFFSMFIGSFLVTSYSSVYFSSLTHVYPFFLGSMLATIVGV
                     RQTTSLVKQLDKIWDLRKTLVVFGGGFGFLVLLTFFVKFTYLFAYLIGFLLASLAALA
                     MILAARVLHEKTHHIQEPKIISFLADTSYAVYLFHWPFYIIFSQLTSNLLAVLLTLIC
                     SYGFASLSFYVLEPWIAGKNTPIVQTLRPLPYIHAILAAGTGILTFIVCMVTLLAPQV
                     GAFETDLTVNGLKQAATNIGQTKVMAERADANSLGIADGTMLIGDSVALRANTALQTA
                     LPGAQINAQVSVTTKTANEIMLNNSQNKFLPKTVVIATGVNNPENYKDDWDSIVKNLP
                     KGHHMILVTPYEGDKTKETYAIVEKAAAYMRELAEKTPYITIADWNQVAKEHPEIWAG
                     TDQVHFGSESSTIEAGAKLYADTIATALQTAQDKPVKSK"
     gene            complement(34987..36129)
                     /gene="tgt"
                     /locus_tag="VXE25_000777"
     CDS             complement(34987..36129)
                     /gene="tgt"
                     /locus_tag="VXE25_000777"
                     /EC_number="2.4.2.29"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004298827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA guanosine(34) transglycosylase Tgt"
                     /protein_id="HEV0771281.1"
                     /translation="MSDSPIKYRLIKKEKHTGARLGEIITPHGTFPTPMFMPVGTQAT
                     VKTQSPEELKEMGSGIILSNTYHLWLRPGDELIARAGGLHKFMNWDQPILTDSGGFQV
                     YSLADSRNITEEGVTFKNHLNGSKMLLSPEKAISIQNNLSSDIMMSFDECPQFYQPYD
                     YVKKSIERTSRWAERGLKAHRRPHDQGLFGIVQGAGFEDLRRQSAHDLVSMDFSGYSI
                     GGLAVGETHEEMNAVLDFTTQLLPENKPRYLMGVGAPDSLIDGVIRGVDMFDCVLPTR
                     IARNGTCMTSQGRLVVKNAQFAEDFTPLDPECDCYTCNNYTRAYLRHLLKADETFGIR
                     LTSYHNLYFLLNLMKQVRQAIMDDNLLEFRKYFVEKYGYNKSGRNF"
     gene            36259..37116
                     /locus_tag="VXE25_000778"
     CDS             36259..37116
                     /locus_tag="VXE25_000778"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF975 family protein"
                     /protein_id="HEV0771282.1"
                     /translation="MNYPKIDLKTIRQESKHFQADTPRLFLLYILPSMLVILSGFLNP
                     LSRIHGTVLEQPFFSILGQILQTYLFPLLVSFIGTILLTSSVYATLTLMKDSKTEPSV
                     KNSLALFDEERFSQTFLTLLLKRFYLFLWSIPNLLGIYLLFYSSFLAKKFVTLHPEFP
                     NLDLSSVETERFLMVFGLYFLASLILIIVGNILYIPQYYAYSQVEFLLCYSLDLGQVP
                     PRRILKTSRSFMKGYKFQHFVLDLQLLPWYFLNWITFGIASFSLLPYIQCTKIMFYRA
                     VLARKRPKA"
     gene            complement(37143..37760)
                     /locus_tag="VXE25_000779"
                     /pseudo
     CDS             complement(37143..37760)
                     /locus_tag="VXE25_000779"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398107.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="pyroglutamyl-peptidase I"
     gene            complement(37867..38235)
                     /locus_tag="VXE25_000780"
     CDS             complement(37867..38235)
                     /locus_tag="VXE25_000780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000022857.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1304 domain-containing protein"
                     /protein_id="HEV0771283.1"
                     /translation="MSIITIILTTIVALEHFYIFYLESIATQSDATSRVFNMEKEELA
                     HPSVSSLFKNQGIYKALLGVFLLYVIYFSQNLEIVTIFVLFVIGAATYGSLTADKKII
                     LKQGGSAILALISILLFKYT"
     gene            complement(38246..38584)
                     /locus_tag="VXE25_000781"
     CDS             complement(38246..38584)
                     /locus_tag="VXE25_000781"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010976657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HEV0771284.1"
                     /translation="MTRYQILLFLLEHSPCNQMAVQERLKIDQAALTRHFKILETEGL
                     VERHRNPENQREVLVETAKYAKEQLVVNPPLQHIKVKEEMESILTEFERTELSRLLNK
                     LVLGIENIEI"
     gene            complement(38993..40135)
                     /locus_tag="VXE25_000782"
     CDS             complement(38993..40135)
                     /locus_tag="VXE25_000782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000746996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="HEV0771285.1"
                     /translation="MKKRMLLASTVALSFAPVLATQAEEVLWTARSVEQIQNDLTKTD
                     NKTSYTVQYGDTLSTIAEALGVDVTVLANLNKITNMDLIFPETVLTTTVNEAEEVTEV
                     EIQTPQADSSEEVTTATADLTTNQVTVDVQTVQVADLSQPIAEAPKEVASSSEVTKTV
                     IASEEVAPSTGTSVPEEQTAETTRPVEEATPQETTPAKKQETQASPQAASAVEATTTS
                     SEAKEVASSNGATAAVSTYQPEETKVISTTYEAPAAPDYAGLAVAKSENAGLQPQTAA
                     FKEEIANLFGITSFSGYRPGDSGDHGKGLAIDFMVAERSELGDKIAEYAIQNMASRGI
                     SYIIWKQRFYAPFDSKYGPANTWNPMPDRGSVTENHYDHVHVSMNG"
     gene            complement(40301..40921)
                     /locus_tag="VXE25_000783"
     CDS             complement(40301..40921)
                     /locus_tag="VXE25_000783"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001172828.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HEV0771286.1"
                     /translation="MQKTAFIWDLDGTLLDSYEAILSGIEETFAQFSIPYDKEKVREF
                     IFKYSVQDLLVRVAEDRNLDVEVLNQVRAQSLAEKNAQVVLMPGAREVLAWADESGIQ
                     QFIYTHKGNNAFTILKDLGVESYFTEILTSQSGFVRKPSPEAATYLLDKYQLNSDNTY
                     YIGDRTLDVEFAQNSGIQSINFLESTYEGNHRIQALADISRIFETK"
     gene            complement(40925..42205)
                     /locus_tag="VXE25_000784"
     CDS             complement(40925..42205)
                     /locus_tag="VXE25_000784"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000473957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HEV0771287.1"
                     /translation="MFKKNKDILNIALPAMGENFLQMLMGMVDSYLVAHLGLIAISGV
                     SVAGNIITIYQAIFIALGAAISSVISKSIGQKDQSKLAYHVTEALKITLLLSFLLGFL
                     SIFAGKEMIGLLGTERDVAESGGLYLSLVGGSIVLLGLMTSLGALIRATHNPRLPLYV
                     SFLSNALNILFSSLAIFVLDMGIAGVAWGTIVSRLVGLVILWSQLKLPYGKPTFGLDK
                     ELLTLALPAAGERLMMRAGDVVIIALVVSFGTEAVAGNAIGEVLTQFNYMPAFGVATA
                     TVMLLARAVGEDDWKRVASLSKQTFWLSLFLMLPLSFSIYVLGVPLTHLYTTDSLAVE
                     ASVLVTLFSLLGTPMTTGTVIYTAVWQGLGNARLPFYATSIGMWCIRIGTGYLMGIVL
                     GWGLPGIWAGSLLDNGFRWLFLRYRYQRYMSLKG"
     gene            complement(42266..43750)
                     /locus_tag="VXE25_000785"
     CDS             complement(42266..43750)
                     /locus_tag="VXE25_000785"
                     /EC_number="4.2.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006595200.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine synthase"
                     /protein_id="HEV0771288.1"
                     /translation="MTLVYQSTRDANNTVTASQAILQGLATDGGLFTPVTYPKVDLNF
                     DKLKDASYQEVAKLVLSAFLDDFTAEELDYCINNAYDSKFDTPAIAPLVKLDGQYNLE
                     LFHGSTIAFKDMALSILPYFMTTAAKKHGLENKIVILTATSGDTGKAAMAGFADVPGT
                     EIIVFYPKGGVSKVQELQMTTQNGDNTHVIAIDGNFDDAQTNVKHMFNDVALRERLAA
                     NKLQFSSANSMNIGRLVPQIVYYVYAYAQLVKTGEIVAGDKINFTVPTGNFGNILAAF
                     YAKQIGLPVGKLICASNDNNVLTDFFKTRVYDKKREFKVTTSPSMDILVSSNLERLIF
                     HLLGNNAEKTTELMNALNTQGQYKLTDFDAEILDLFAAEYATEEETAAEIKRVCELDS
                     YIEDPHTAVASAVYKKYQSATGDVTKTVIASTASPYKFPVVAVEAVTGKAGLTDFEAL
                     AQLHEISGVAVPPAVDGLEIAPIRHKTTVAAADMQAAVEAYLGL"
     gene            complement(43826..45103)
                     /locus_tag="VXE25_000786"
     CDS             complement(43826..45103)
                     /locus_tag="VXE25_000786"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001277926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamylcysteine synthetase"
                     /protein_id="HEV0771289.1"
                     /translation="MSCSIDLLKHRYLKNIKENPELFVGIELEYPVASLEGDATDVEV
                     IKDLFHYLVSTLDLTVAKVDDFGNLIQLVDPISQDAILFEVSYTTIEFAFGKAETIQE
                     VEERFSIYMEAIQKKLAESNHAIVGCGIHPNWDKNENCPVAYPRYQMLMDYLNLSRNI
                     IKSDLHHFPEYGTFICGSQVQLDISKTNYLRVINAFTQIEAAKAYLFANSEFSGADWD
                     TKISRDIFWEESMHGIYPENVGVNARLLNDEADFFDYLNHSAIFTAERDGQTYYFYPI
                     QAGDYLATPEIQAFALNGDEVIISPQEKDFETHRSYQYQDLTTRGTVEFRSVCTQPLD
                     RTFASAAFHLGLLVNLDKLEAYLETAPFFKVFGYDYKSLRRQFSKKNLTDEEETTIIE
                     FSKDLLLLAEEGLVVRNKEEMTYLQPLREELSL"
     gene            complement(45210..45293)
                     /locus_tag="VXE25_000787"
     tRNA            complement(45210..45293)
                     /locus_tag="VXE25_000787"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(45257..45259),aa:Leu,seq:caa)
     gene            complement(45303..45374)
                     /locus_tag="VXE25_000788"
     tRNA            complement(45303..45374)
                     /locus_tag="VXE25_000788"
                     /product="tRNA-Gln"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(45340..45342),aa:Gln,seq:ttg)
     gene            complement(45385..45457)
                     /locus_tag="VXE25_000789"
     tRNA            complement(45385..45457)
                     /locus_tag="VXE25_000789"
                     /product="tRNA-His"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(45422..45424),aa:His,seq:gtg)
     gene            complement(45472..45542)
                     /locus_tag="VXE25_000790"
     tRNA            complement(45472..45542)
                     /locus_tag="VXE25_000790"
                     /product="tRNA-Trp"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(45508..45510),aa:Trp,seq:cca)
     gene            complement(45547..45627)
                     /locus_tag="VXE25_000791"
     tRNA            complement(45547..45627)
                     /locus_tag="VXE25_000791"
                     /product="tRNA-Tyr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(45591..45593),aa:Tyr,seq:gta)
     gene            complement(45640..45712)
                     /locus_tag="VXE25_000792"
     tRNA            complement(45640..45712)
                     /locus_tag="VXE25_000792"
                     /product="tRNA-Phe"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(45677..45679),aa:Phe,seq:gaa)
     gene            complement(45716..45789)
                     /locus_tag="VXE25_000793"
     tRNA            complement(45716..45789)
                     /locus_tag="VXE25_000793"
                     /product="tRNA-Met"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(45753..45755),aa:Met,seq:cat)
     gene            complement(45803..45892)
                     /locus_tag="VXE25_000794"
     tRNA            complement(45803..45892)
                     /locus_tag="VXE25_000794"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(45854..45856),aa:Ser,seq:tga)
     gene            complement(45975..46048)
                     /locus_tag="VXE25_000795"
     tRNA            complement(45975..46048)
                     /locus_tag="VXE25_000795"
                     /product="tRNA-Ile"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(46012..46014),aa:Ile,seq:gat)
     gene            complement(46084..46154)
                     /locus_tag="VXE25_000796"
     tRNA            complement(46084..46154)
                     /locus_tag="VXE25_000796"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(46120..46122),aa:Gly,seq:tcc)
BASE COUNT        13027 a        10561 c         8099 g        14471 t
ORIGIN      
        1 gtttcctact gcctcggaaa ggttaccaac attatcaaac aaagcgacta gcgccctggt
       61 aatgcgttct ttttgccttc caaggccatt tgcaatactt tcggcaagga aaacaccgat
      121 acctagcccg atagtagcta ttgagcctgt cacttgccct aaagcataag caattttctc
      181 agccattcgg ttaaaggcat tcacaaccct tgggtcagtg gcgatttctc ccattgtctt
      241 agctatttgg tctaaggcag tcttaatgcg ttttatacct tctggtctaa atgctgcatc
      301 aaaacctttc ttgaagaggt caaacaaccc tttgagctta tctccaagac catcaaaaat
      361 gctcttgaat ttgttgtcca tgtcagtcaa ctcgacttct ggcaagatgt ctttgaaagg
      421 tccgccaccg cctccctttc ctttaccacc tttgccaccg cctccagaac cgcctgcgtc
      481 gtcatctttt ggtttttgca agatgttaat ctcatcaaat cccaaaagac ctagcaactc
      541 tttagcagct ttcttagcgt ttttggctga gtctccaaga ttgtcagcaa gtcctcctgc
      601 tgaatctcca gcgtcgtcta ctgcgtcagc aaggtctcct gctccgcctg cagcatcctt
      661 catggcgtta cccatgtctc caactgctcc accaacacca tctttcactg ttgctttctt
      721 gttgaacatc aaagtaataa actcagcgag tttagcagta acgttcttca aaaccatagc
      781 aaaagagttc aagacaggca taatggcatt gataatcggt aacatagagt taccaaggtt
      841 caatgctgcg tccttcatca gcgacttaaa taggctgata cgaccattta cagaattaga
      901 caaggtattc ccatacttgg ctgtagcctg ttccagaata gccataaggc ggatttgttg
      961 ctgggtttgg tagtctaatt gttgccagct ttgtccgttt gcgaacttct taaaagcttc
     1021 agtggactta atcatagcca cattgacgtt gattcctagg tcctcaattg cttcggtgtt
     1081 ccctagtaga cctgagcgaa tccgctccat aacgtctgta atcgtgcgcc ctgaaccttc
     1141 agcaaccact gccgatgtct gcaacatctt agcagtatag gcgcttagct tgttggtatc
     1201 tttgataaat ccagaaaata agtttgaata gactgcaccg tagttggtcg cctcacccac
     1261 tcccatattc atagcgttgg cgttatcgtt aacccatttc aagaaagatt gcgaactctc
     1321 gcccatctgt cgcttgattt ggttcataga cgctgacact tcaagagctg tctgcgttga
     1381 atacattcca acatcaagta atttcttacc aaggattgca aaaccagcaa acttagccag
     1441 cttaccaaac gcactaccga ttgagttcga ctgttcacga actttggcag tggcattttt
     1501 cacttggtca gatgttcctt tgacctgatt ctcgacttct ttcatctttt tcctgaaagg
     1561 cgctatctca gcgtcaatca tgaccttcaa ttcatcaaga gttgccattt acttcctcct
     1621 tcctttttcg attatgtctc tctgcaaaat cacgcatccg ttccttatgc aacaaaagcg
     1681 cttgtctctg tcgttcctgt tctactgctt gctgttcttc tacaaacaac tcaggcgcat
     1741 attcccaaag ctcaacaatc ttagcgtcat tggacagtaa taaggaaaca tgattagtta
     1801 tcattcgcga aagtatgtac gagtcaataa tcttttcttt acgctcttgg attttgacac
     1861 ggttgtagct ttctatcatt tccctgattt caagcaccgt taaatcccaa aaatcaagag
     1921 gcttgccccc gatgtctaaa aacataggat aaagcctctc aataatctgc gttaccgtta
     1981 agattactcg actactgtca ttttcttctt ggaagttttc ttgtccttgc ttcctcgtgg
     2041 agtaaaaccc gatacttcaa atagcggcat caacacctct gtcatgaatg tcgtttggtc
     2101 tccgccgtta tccacgtatt catcgtatag gtcgtagaca tcttcaaagg aatacccatg
     2161 ttcatactgc tgcaaggctc catgaactaa caacagcata actttcaaag gcggtaaagt
     2221 gaactcttcg ccagcttcag gcatgaaaat ctttaacaag ttcatgccga ttttttcttc
     2281 cacagttgca gcttgatgag atgtcaaacg tagcttcaac tctttttcgt cagtaacttt
     2341 ccaagttgtg tattttaacg ccatttaatt aacctccaat tccatcaacg aatgtcaatt
     2401 cagactgcaa tgcaatctta agtgtgaact cgataacggc attaacgccg ccaccgccca
     2461 gtttaacgga tacttgacct tcaaaagtga ccttagtacc gtctgggtag gtttgttcaa
     2521 agtagagttt tttcttgcca tctgctgcct tacgtaatac acggtaagga gctgttgcgc
     2581 ttgaattatt ataagcgaac ttgtactcaa gttctcctgc gtccccgata ccaaactcgt
     2641 acttcttcac cgtatctgca agagtagtat tttctacttt ttcgggctcg ataccaaatt
     2701 caggtacttc cttaagccct acaagattct gataattgcc tttcgtttca ctaaaggcca
     2761 atttaattcc atttgctaac atgtttaatt ctccattcta aattgaaaaa caagctctga
     2821 gtctaaatca acgacacctt caaaacgcat gaccttatgt ctcaaatgag acgggtctgg
     2881 cacgtcttgg cagtcagttc ttcgcaaacc taaagactca aaaatctgat tgattttaac
     2941 agctaactca ctagtgctgg tatcatcaaa gatatccacc ttatagcgga tagatgattt
     3001 ttgttcctgg tcatcaaacc aatcacccgg cttgttttgt tcttctaaaa aaataacgac
     3061 tgggaaagtc tcccaatcgc taggataagt atcggtcaca ttatctgcaa ccttttgcaa
     3121 ttctttataa ataacaggct tgatattaat cattttattt gttctcttat ctttctacgg
     3181 acataattcg aaatattctt agacacacgc tcttgattgt ctctcaaagc tggataaaga
     3241 taaggctggg caggttgacc atacatcttg tagaactccc caatcttttg aaagtggtac
     3301 ggtcctacat ttatttggtc ttcatgcaca taccaaggat tagacttgta agtcacgctg
     3361 acctctggag agatacccga atggttagct tgtcctattg gtcctgttcc aaactcaacg
     3421 taaggagcgt atttaaggtt ggtgtaaact tcgcctatag ccttatctcc gtccattttt
     3481 gctctagttt tgatactaat tataagctct ccatctctcg ctggtgcgag tcttcttgca
     3541 tctgcttgga caacctttat agtagcattg tgtaccgcac gtaagacgat atcctcgcca
     3601 gtttttttac tagccaatcg tctacattta gctataagcc tatctgcccc tagtagccct
     3661 gacacgctct aactccaaaa cttgatgatg tgtgtagacc tttttagaaa taaccctgtg
     3721 agtcacttct gtctggctat cgatacacac accatctttc actttgatag tagctgactt
     3781 gttggcattt gcgttcaaaa tatcattgac acgctcgcca tacaattcag attgtaactt
     3841 gctactagct ggccacaatt caaggcggac tgtctcagct tccttggcat acccttcttt
     3901 cgcgacacct tcctcagtga cagtcttttc aaaccgtcgc attggataag gtttcagtct
     3961 actctgcttc aaaaacatga cctgccaccc ttgctagcct gtgcatgcgt attcgctgta
     4021 gaagacccgt agacaggcca ttttctccgt agactactgc tataccacct tcggttctag
     4081 aacgctctcc ttccgctcct gagcggttgt ggagctcgat agcaacctca ggtattaaaa
     4141 gacttaaagc aggtgtcaaa gatgtgcgat tagtctctga caagataaga tttgtagccc
     4201 ttgtttggaa caacatgaga agctgagtat cttcttcgcc tgttaatttc ttcagcaact
     4261 ctatagacat atcaatcctc ttctaagaac tcaggttcag ggaggatttt ctcaagaaca
     4321 tctgagatag cgacaccgtt gctggcaata ttgtcagcca gctcagcata gcgctcctca
     4381 gtaatctcaa gttcctctcc tgccagtcgt ttcacatttg attcccaatc atagaaatct
     4441 tgtttgattt taaatttcat aactaagacc tatttcttac cagttttttc tttccagtta
     4501 gctgagtcag agcctggtgc attggttgag ctagtgatgt ctttgatagc aacatagact
     4561 ttatcttcat gcgttactgt atcaccttct ttataggctg ttccagtctt ccacgcttta
     4621 gcacggttca ctgtcttgcc ttgggctgat tttttagcag caggcttaga atctgcaatt
     4681 gtgatgatgt attttttgaa gtgttcaagc acaaatgcac cagtgtaaag taattgctct
     4741 accaattcac caaatcgacc tggaatgtta tcgttgtact tagtattgtc tacttgtact
     4801 ggagatgtaa caacacctgg agcagtagca agggcattaa cacctttcaa gaatttagaa
     4861 ggaactttat agactgtgta atcatccaat tcaccaacat atccttttcc aaggactttc
     4921 ttatctgcgt caccatgtgg tagacgaacg atttcagact tgatcgcttt gtagaattta
     4981 ggtgttacaa aaagcaagcg ctcttttgta attccaagct catcaagttt ctcagaaaca
     5041 tcaagaattg cgttgtatgc gttgttcgct cctgcttctt tgcccatagt aacgttgtcg
     5101 ctaacattac caagcgctgc actaaaacgt agttcatcaa gatatggagc tactacttct
     5161 gccgcttgac gggcaataac ataattgata ttcacttgac cattagagtc acgttcgtcc
     5221 aattgatcta cgaaacgacc ccagtatttt tcttcatcaa gggtataaac cttttcttca
     5281 acttcaacgt gatcaaattc gttgtctttg ttacgtttgt agtctttcaa ctctgttgtg
     5341 ttaccagttg ctactgtaaa agagcgacct tgcaaggtta ctgcatcgct tgatgtcaca
     5401 agtggtgttg aatatgaatt tactgcaagt acatcctcaa taatcccaag atgtttcttg
     5461 cgtgattctg ctgtgtttaa ttcttcaaat gccatttatt tttcctcttt tcttttatta
     5521 caagaagtct ttacgccatt tttccgtgac ttcttgctgg actgtttgtg catttttgat
     5581 aggtgcacta cctttcatac gttcagagac tcccttctga actgactctt cccatgcttt
     5641 ttggatagag gtgatagatt cagataccgt ctctgcgttt gtcaaatcga ctacatttac
     5701 taactcaaca ggtaagtcac gttcacttag cattgcttta gcctctgcgg tcaattcctt
     5761 acgagcaata gccttttcac ggtcagctag ttcttgctca cgctgatcca actgatattt
     5821 ctgtttttca tcagcgttca tcttagcaag cttcttagct tcgttttcct tggcttcttg
     5881 ctcagcttcc catttagagc gctcggcaga tagcatctta ccgatttcag cacgagtgaa
     5941 agttcgttcg tgcttttctt cctgcactga atcaacattt ccttgagtgt cgacagtctc
     6001 agttgattca gtagatacag ttgcattgat ttcttctgac ataattgtcc tccagcgatt
     6061 acgtcgccac tcgataatct cgctttacgt ccggcgacgg aacagtgcag cttttaatgt
     6121 catcggcaca gtttggacaa tataaaaacc gtacgggatt ccatacggtt agattatttt
     6181 gtattttctt caatcacttt ttttacaaat gctatgataa tcagcatcaa aaacaaaaat
     6241 accaaccacc cgaaagcgat tgatacccaa tcccatataa acatatctta ctccttttaa
     6301 tgtcacaatc aatcaacttc atacgataat gaatgaatgt cggttaatat tttaggtagt
     6361 aactcaatcg cgctgaacgt atccgcccca taaatattta actctaattt cactgtcgct
     6421 gattcaattc cgcctgttcc tgaaaattct acgttagtta tcccaatttt tgctttatcc
     6481 attttcaatc ctttctgggt acgaaaaaag cacttagatt tctctaggtg cttaagtaat
     6541 aaattgcatt tttatatttt ttaacacgct cgtagtctgt attggtaaca gatttcaaac
     6601 gtgataaatc tgagttgtgt ttcaaatctg caagttttac aactcttgct aaattatttg
     6661 attttacttt cccaagatat tcttgataac tttgaccttt tttctttgtc aaaatttgta
     6721 ccgctgtaac aacttcattt gacaaaccag acgccaataa atcggcagca gttatatcgc
     6781 tatcctcaat cacatcatgt aaaagagcga cagctttttc ttgttcagtt ttgacttgac
     6841 tggccacata gagaggatgc tgtatgtaat caacatccgc tttatctacc tgccctgcat
     6901 gtgctttttt agcgatagcc aaagcaatat caatcatgcc gctaccatcc tgtcaatata
     6961 agtaaatgca tcattttctg aaatttcttc aaaatccgta aagtcattaa aaaagatttt
     7021 attaaaccaa tctatgctat taacccactt tttttcaatg tcaaaaactt gcatgacacc
     7081 atcaatcaaa cgaagtactt gagcattgtt cgtcgttgtg cggtagtatt taatatcttt
     7141 cacatcactt caccctctct atatttttag gaatctcaag cccattgctt aaatcaagca
     7201 tttccttaaa taatttcatg cgttctagat cagatgtatt cgtatcacga tacttctcat
     7261 agagttcatg taatgaacca ttttttaagt cgaaactttc ctgagtatga tactgcattt
     7321 caaagttgat accatctttt tcaacgactg tattcacacc tttgtatggt ccatctacta
     7381 accaagtgtt ttttactttt acaattttat aaccttctgc gacaagcttc tgtttcatct
     7441 tcaaatactc ttctgtaaaa gtatcggaat cgaaaatagt tgtgtacctt aaggcgtcat
     7501 taatcttact cacggctttt gacaaactta tattttcaac taggctatct gcaataattt
     7561 tacgtgataa cgactcaact gttttcttcc taaattcaag acctgccaat ttgttttctc
     7621 ctgcgatacg ttgcatatca cttgtaattt ttggctcaac tcctgaaatt ttggacaata
     7681 gttgttcgct ataaaatttc gccttggctt ctcttgtatc ttgattatac accttttccc
     7741 cgtctttcgc aacatacttg ctataccact ctttataagt catatcggca ggcacgtact
     7801 caactttacc tgtctctgga ttccttgctc tgcgcttcaa cttgctgtag tctgcgtcct
     7861 catcgtatcc gacagtagta gacctacacc aagggtgcat aggcggacaa ttgacaccag
     7921 ggacagcctt atccctatca tagacctgat tgtcatgctc ctgacaaatc cgtgatgtac
     7981 gcttgtctaa gacggccaca aagatatact tttctatgtc tgcttcttca tagctgagta
     8041 gttccatttg gttatgaaaa aaggctgatt ctgtccgaac caaacgcctt gcatcgttct
     8101 gacctacatt gaacctctca gcaattgctt gtgcagtttc tcgtgtatct cggcctgtca
     8161 taaggcttat gagtaattca tcttttatgc ttgatgtaag cttccctgta ttcttccaga
     8221 tgtttgttga gtacgtactt ccatctccta cccaactaaa agactgtaga tgtttaatct
     8281 cgctctcagg aagcccagaa aagccgtatg ctagtcctgt ctgctgctgc aggtcaaagg
     8341 taaccttgta gtaactatcc ttcatcaagt cgctataaaa ggcgtctgag cctgtctttt
     8401 ctgaatgata gatagattca cgcatacggt ctaaatcatc actcaaacgt tctagacgct
     8461 tcatacggaa agaataagcc ggactatcta agtcagccag tagtctttgg atatttggat
     8521 cattcggtct cgcttcaagt actttacgaa gttcattcag atttttcttg tctttcatgt
     8581 tcttcaagac ttgtctagct tctacctgac ttagaccata atcacgttgg aacttatcaa
     8641 aaatcttatt gacttcctta tccaagtaag tcttggcttc ctgatagacc ttatcgaact
     8701 gatctgcctg cttttcggcc ttgtccatct gctggtaaat cagattggct ttcctcttcg
     8761 cccaatactc ctgattcttc atcctctacc tcgtcttcgg gtttcgtgtt gtcttggtta
     8821 aacatcggca tgtcttccat gttcttcttt ttctcttctt ccaaggcttc tagctcagca
     8881 tcagggtctt ccacaaacgg caagagagaa ataagctgtc tattcgtcac tttaccttca
     8941 aggttgttca cgatctgaga gatttctaac aagttcttag gcaaaccacg actgaattgt
     9001 ggaacgattg aatgagactc taaagcaatc tgcttcatac ctaagtaatg agcaaaaatc
     9061 gcaatacgct gacgcaatcc tcgcttatag ttcgcttcct tggtcttagt aatcatctca
     9121 aggcccatca gcttaaattc catggctacg cctgatgtat tccctgcgaa attctcatca
     9181 gtcaaattag gcacatggct aaatgtgtag atgtcctctt taagagctgt acgcaagatt
     9241 tcagtagcac tttcgtccag cgtattcttc aagaactcag cccttgcact atcgcccggc
     9301 aattccaaaa gaccttcttc agaaagaatc ttcattgcta ccttagcgtc ttctggagtg
     9361 tctgctaact gcgtgccata caagacaagg atagactcta cagcctgttc cttatcattg
     9421 acacgattcc ccatcaagga attataagcg tctatcaagc taatttgttg ctcatagtca
     9481 ccaattgcaa agtgattgtt gcgatattcg ataattggga tttgaccaag gttgtgaggt
     9541 gttgcctcct cgctctgagt tgttcctgaa tctgtacttc tcagcaccat gtgatagtgc
     9601 agattttcgg taaagacctc agcctggtac ttggtagtgt ctttcgtatc gtcttttact
     9661 tcatagtaat agaccgcaaa caaaggcttc cgctcaatac tatcatcgta gaccatgaaa
     9721 gtattctccg gatcaatact agttgaatcc aactcagcca taccctcttt agcatagatg
     9781 tactcgtaag cacgaccata gatagccatg ttcaaagcat tctgagcatc tacttggtca
     9841 atctcagcac catcaaaggc tgtaagtagt tcatcgatat caccgtcagc agtattgtta
     9901 tacttgatag gattgcccat aaaatagccc gtagccgtgt ctgcgatatc cttggcatga
     9961 ttggctaccg tcttgtaatt cggtgcgttc acgttgcgtc tcgtgtgttt taagatagca
    10021 tgctcaccca aatagtagct tttaagcttc ttcaaatgcg agccttcagt gctatgtatc
    10081 gttatcaatt tgtaaatcag gtctttcttc aaagaaccct catcatatcc atcccgtgga
    10141 taggttaaat attggtacat gtctttcctc tctatagacc ataatcagaa cgtctgcgga
    10201 cggttgcttt tccaccttcg atacattgaa ggctgtaacg caaagcgtcc atcaagtggt
    10261 tgtttttatc ctctggttta ttcaaccagt tgccttcttt atctcgctgg tagcagtaac
    10321 tataaaattc atccatgatg tttttacaat ctggatgcac ataaatagcg tatccttgca
    10381 atttggatac gcctgccata atactatcct tacctttccg actctctttt attctagata
    10441 tgccatgttc tgacctgagc tcttcaatca gccgtgactc tgcgctatca gcaatgattt
    10501 gtgagcgatg ataacctttg tcttttatca tcttcgcaac ttctttggtt atcaatccga
    10561 ctttatacgc ctcatcaaag acataaatct ctttcgtcgt gtcatttatc aacgaacaac
    10621 acaaagcagt tggatcatga gtaaaaccaa agtcaagacc gatacataat ttattagctg
    10681 aatcttgtag taattcatct ttattgaaat ccttgacagt cacgttttcg tagattaaac
    10741 cttcagcaac tccccattca ccatcacaaa cgattctcgc acgccttgga tttgtgtgat
    10801 acaagtcctc ataacgctta atatcgactt catcaagcca ctcattgcat ttgtaagtgg
    10861 ttgtagtagc gaatgtatca gctcggctag tctcttcatc aaagaacaca cgtttgagcc
    10921 agtgcctctc attccacggg ttaaatgtga ctgtgatttg tttaaagaaa tcaggtacat
    10981 ctaggctacc acggattgac tcaactactg tactgaactt gtcttcagtc tcaatttgat
    11041 atgcttcctc aaaccatgcc caacaaagac tgccgacatc gaccgtgata gatgtgattt
    11101 tgagttcatc atccaaacca cggaatagga ttttttgacc agtcgctttt acagttattt
    11161 caggcaaaga ctcgttaaat ttaaacaaat gagtcacacc caacacatta cacgcccatt
    11221 taaaatccgt ataagttgat tgcttgttgg tattcgaata cctacgaata acaagcaagt
    11281 tggcccagga atatttcaaa agacggacaa catagtttaa agcggttgtc ttggacttct
    11341 tcgaaccacg ggaccctttg actacacgat aaagacttct tgagcgccag aactgtccgt
    11401 acccagctcc tactgtctta ggtaagtcaa cgacaatatc gttttgctta atctggtatg
    11461 tctgactcat ttgcaaacac caccgttcca gaaacatccg cctctacctt atccgtccaa
    11521 agcctatgcc gtttaccaag aagttcagcc gccttgattc tatctttagc tcctacatct
    11581 atatccgtaa tcgtctgccc tagttctcca atgcttatca aggtctgttc ttgcgtctct
    11641 cctcgcatga ctgaagttag ataacctaag acctcttgct gatccgcaat cttttcagaa
    11701 tcaagctgtt tcagtcgttc atctatatag cttttaatct taggattctt tagtaactta
    11761 tgtccttcaa cgcctgccac tctatcacta gaaacacgat aacctgcttt cttataggct
    11821 tccgtcgcat tacctgagat gatgtactca tctgcaaatc tcttttgttt tattctcaat
    11881 ccactcaatt ttccatcacc acctttcaaa caatcaaaaa agccacacga tgtgcgacct
    11941 tcttgcaagg cgactactac cttgcgtgcg tattaaattt tgacttcttt tttatttttt
    12001 gtagtcttta aaacctctga gggaatcaaa ccctctagct tataacttat ccggaatata
    12061 attagctacg caatcatgcg aggtccagtc gcttccgcaa ccatttttaa gttaatgagt
    12121 gataggagtt aatgagtgat atgtgaatcc ccacccagaa gatttaactc attctgggac
    12181 acaaacactc aaaggagagg ggaggacttg aacctccaag gccattacag ccccctgaca
    12241 ttacaggtaa ccatctacca attctgagac ctctcttttc aattcttgat actaccattc
    12301 taacagattt ttagaaccgt gctgttccaa aaagtcccat aagctcacta tgaggttaga
    12361 taacttcttc caaagctaag accgcctcat tttttaacct gtagtaggtt gtacgactca
    12421 tattcaaatc ataacaaacg ctatcagcgg tgcctttgtt gatgtaagtc attcttaata
    12481 ctgccctgta ctttggattt ttaagcctat tgatcattct acctaattca agttttctgt
    12541 taatgacctc tttagtatcc tgctctatag cctctttcat cactaccaac tgagtataga
    12601 catcatcaac ttttctagtc tgtccacctt ggactttaac ctcggaccat ttagggcttg
    12661 agagcaaacc tgcctcaagc tcgttaattt cgtctatacg gctttggatg tccatgtcca
    12721 gatcctgcaa ctctttcaag agctctttag ccttgttcac tctctgtctc ctttgtgata
    12781 taatagtctt tgcgagaact attagctgag gcagagagtg tcttggcttt ttttaatgct
    12841 taaattcgtt gaccaggtcc cggataaaga acttccaatc agattctcta aacgtcaaga
    12901 aacgatctgt agtaaaattt ctaagtcttt tatagaaaag catctttagt tggattgact
    12961 caccaacact cagtaaaata ccggggaagc gatgtactga atgcactcta tttccgtatc
    13021 cagaaatatc taaatgtatt aacgtttctg gatatatgcg ccccatacta gcttcaactc
    13081 cgaactcaac cttaacttct tctacaattg gaacttcgtc aaaaattggt cgtgcagaaa
    13141 atattggcga cggcgtttct tgtttttttc ttcttcctga atatggatat ttacaaggtc
    13201 tcatttgcgt cctccaaact ccttattttc atagatgttg ccgatgattt cattttcttc
    13261 aatttcagtc cataaacata ctgcgtcact gcccgtatca attacccaag aaccctcaag
    13321 ctgcttaaca atccctataa attccttgtc atactcatag aaaccgccaa tttcgtcagc
    13381 tctacccaaa aatctagtag ttcgtacaat atcgccttca aagatttcct tgccgttctt
    13441 gtctttgagt cctgttgatt gcatgagttc gatttcgtca aaatcataac aatagatatc
    13501 tctatcgtct ggtaaaccat tctcaaaata aacttgttgt gtcactattt ctttgttttc
    13561 gtagtcaata gcaagaatgt catctgaaaa aaccatacgt tttcctattt ttacccacac
    13621 tctaaatttt ggaatcattc ctccacctcc tctatatcaa tcccttcaca atcaaagacc
    13681 cagccgaacc cagtatcttc gagttgtttg cgagtaaatt ttgtagctat gccacccaga
    13741 gagaagaata gtctcttatc cccagcatta taatatagcg gttgtttcgt ctctttcatc
    13801 accactgtat accgcttctc tttttcgacc tcgtagccgt taagccaagc aagacagaat
    13861 ttttcgatgt tattttcgta aaaccaatca ggaactttct tatcataatg atcttcaatt
    13921 actctcattg caccgtaaac atgaaaattg tttttctttt taaattctat atattccgcc
    13981 acacactgcg gaactttgac tggtttttgt tcgtctagtt gtttcaagtc ttctagaaaa
    14041 atttgacgag ctagctctgc tccttcagca tcccatacac cctcaagttt tttatacttc
    14101 tcaattaatc gctgtacatt catcttagtt tcctctataa atcaaataaa ctgcaataac
    14161 tacctgagcc atgcttggcg aataaccaac ccaatcatca aactccttag attttggcaa
    14221 ccaatcctta gtagctccca aatcatagtc tgtaggtttt tcatcagcga agatgcattc
    14281 catcgctccc ataaacgtca taccatcttc tgccatttcc caaaaatagt ccgcccggtc
    14341 tttcaccgct tgtggtaaat cttgcttggg aggttgcggc ttcccgtctt ctaccgtcca
    14401 gttgtatact tcattaactt tttgctttaa ctcttccatc atcttccaac ttcttcactt
    14461 tccgtcttaa ttctcattat cttcctcctc aattttaata acggccctac cgtttgggtg
    14521 tcgtctttgg tgtgatgtgt aagtgtaata ctttaacatc ctttcagtaa ttcctgtctc
    14581 gctactgatc tgcgctaatg ttccaagcgt aacaaacaca tcaccttgat ataatgcgta
    14641 gtcagccatc tgctcctcat ttcttcaaat actcagggat ttcatgacct caatctcaac
    14701 ctctatccgt ggatttagac tgtagaactt gcctacatca tgtagcgcta tctgaccgtc
    14761 gtcctggaag acgatccctg acatgctgtc atatagcgct ttttcgtagt tatctatgtc
    14821 aggctttttg cctactggta taatttcatc caggagggcc tgttggttct tcttgacttt
    14881 agaaatgtac tgaggaggtt tgatataaaa tctaagccgt gtcctcaaag ctccctcaag
    14941 gataggctga cccatgtact gattagcaat gagcagctgg caatgattgc gccatgtttt
    15001 catatccttg tcttcgtaag ttgtggtaaa actcccacgt cttgcaaacc ttggccgtga
    15061 ttgaggttta ggctcaatgt tcagggtcaa tttcattcaa gagccccctt aaatcctgcc
    15121 atctcaaaga gattttctct gttttcgttt acgaactcaa agaatttttt aacctcttgt
    15181 agcgtcttga tgttgctctt gactcgtgtt aatgaggtga aaaatacatc atttttggga
    15241 attgccttaa ctctgcactt gtagaccggt tcaaaaaggt caccattgtc atctagtgta
    15301 ggagccgtgt ctttgttatc aaagctaatg ctcatatcat agtttagagt cgtaacgacc
    15361 tctatttttt gtttatcaat gatgatagca atacgttctg tcgcattgat tttacttgcc
    15421 atgttctttc tcctgttaaa aaagtgtcgt ttgcaaaggg tacacatctt caaacggtac
    15481 tccaagtctt agacagtctc gtttgatgtc cagtgtagag atgacgtact tgacgccgtt
    15541 gtttttcttg tcatagtgtg gaaaagtgta cccgtcattt tcaattttgg ttttaatgtc
    15601 cgttttggtt tcaggtttcc aatccaccca atccgtccac tccattcttg tcctcctcaa
    15661 actttacaaa cgttagccag tgtgtggtac ctctttgctg accaaataag ggcttgaatg
    15721 gtatcacctc tagtaatttc tttacattta tctgacagtc agaccattta aagactagtg
    15781 tgccgccaac ttttagaact ctcatacatt cttcaaaacc cttggccaaa tcttccgacc
    15841 aggtaacttt gtccagctgt ccatactgag ctttcattat cgaattaggt ccagcccatt
    15901 ttagatgtgg tggatcaaac acaactagat taaatgtgtt gtcttcaaaa ggcatgtcac
    15961 gaaaatcacc gataatatca gggtctacat tgaccttttt gtcatgtatc tcaaatgttt
    16021 cttgcctaat gtccataaaa attgtgtgac tttcgttttt atcaaaccaa aacatacgac
    16081 tgccacagca agcgtcaaga attttaattt ttgacatata tacctcctaa aacggcaaac
    16141 cgtcatttgg gaggtcaaag gggttaggat cggtaaaagg tgagctattc ccattttgga
    16201 aactgttgcc ttgtccgtgc tgactgttgc gactctctag cagaactaca ctctcagcga
    16261 ttaccacagt cacatatcga cgctgaccgt ctttctcgta agatctaact tgtatgcgtc
    16321 caatgatccc aataagagag cccttgctgc aatactgagc aatgatgtca gctgtacctc
    16381 tccaagcttg aaaattgata aaatcagcct cacgctctcc attttcgttt ttgaaattgc
    16441 gattgactgc aagcgtgccc tgtaaactag atacattatt aggcgttttt cgtagatcag
    16501 gaggcgctac aagcctccca accagtgtga cgttattgat catctgattt gtccccctct
    16561 agtgctacgc tctcccaaga gataccctaa aaacatccat aggatagcca tcccaatctc
    16621 tttgataaaa tcattcatta tttctctcct ttgcattcat aacatacatt ttgacctaca
    16681 tcttttccct taattattga taagctacca catttctcac agctgattat gaaacctaaa
    16741 ccatttgaat taatactgct tatattgttc tctgagggaa ctttgtaaat aatcaatgcg
    16801 gatgtatgcc aatattcagc actgactcca ctgtcagcga cagcagacac atttgattga
    16861 aatttgatgt caatcaactt aatgcctgga ttttcggcaa gccagctatt tatttggtcg
    16921 tcaatcacct catgatgtgg ataatcacat gaaaaaaata cggttttaat catattcccc
    16981 tcctggattg tgccaccaga tcatcaggtc ttcctgatta tctctgatgt actgctcaaa
    17041 tttttcaaag tggacgatag catgttttaa gcgttgcata ccctctccag attttgagca
    17101 aaagctgaaa actttaaaga caggctcaat catgtcaata atttctacga cttggccatt
    17161 gaggttccag acgctatcct ctcccacatt gaaatcaagg ataaactcat cccctaggtt
    17221 gtggataacc tgcaatttct tgccgtccga gtagatggct acgctgtcag atatttttct
    17281 gatgtccatg gttaccctcc ccattgactc tggagaaata tcccaagatt tttctatctc
    17341 caatttcctt ttttcgccat acagagtcgc taataggtcc tctatttttc ctattaactc
    17401 atcaggcacc ccatattcag ccaattcttc tgaaattttt tcaatttctg tcatacttac
    17461 cacccacatt gttcatttag ctcagcctga gttaatggat cgatacgttg ataaccgctg
    17521 acttgatagt tctttttaaa atcaaatccg agtttactta gaccagcctt gaaacagtct
    17581 ttttcggctg tgtctacaaa atacacctct aaagtcattt tttgggcata tcgttttagg
    17641 tcattttcag cccctctaag agcgttaggc tcattttgga ggatttgtcc accgtccaag
    17701 attttgcccg tttctgggtc aaaatttggg gtttccgttg attttggagc ctgttcttgc
    17761 tgtttggttt gttgggctgc taaaagttcc tgactttctc gctctgctcg ttcttgagcc
    17821 tgtctgattt cttccttttg cttttcaaac tcataatcag ctttgatttg tccaaagact
    17881 tcagcaagag tcaagtcttt cagctgtcta atgtaaggtg agtcagtcat gccatactca
    17941 gcacataacc ctgaaatagc tgacttggct ttttcaaatt cttgttgttt ctgaaattca
    18001 aatgtgacca tgtcatcaag tgacttcata gtggcttttt taagcgtcac gccatctgcc
    18061 ataaaatcgc tagctttgac atactcaagg gccttttcat caaagagacg aggatccagc
    18121 atgtactcag ctgatttgtt ggctaggtaa ctcttaaccg tatctatttt tagttgtctt
    18181 tgatgttctt cgatttcctt gatacctttg tcaaattcac taactacggt tgcaaatggg
    18241 tcaataattg acttagcata actatcccat gtgttagctg tctctgatag taagttttta
    18301 gtgtcaatac ggatacgatt tttagactca attaacttgt taaattcagc ccgctttgcc
    18361 ttgtcgtctt tgagagttcc agctgtagga atatagtcct tgtacttctc agtagcctct
    18421 atgaggtctt tttcaaaaga ctctctagta agttcatccg ttgtgattat ctcatagatt
    18481 ttattgattt tcttatcatc aataacctgt aattcttgca tgttgtcctc ctaatattca
    18541 agttcaccgt ctagcaattc gccctggatt gattcctcag tttgagcagg ttcaggatct
    18601 gcatgatttg cctcttgctc tttgttgaat tgctcaattt cagccatctt gcgtgctacg
    18661 acatcctcac ggctctcttg aggtgtgacg tctttgatac ggtcaaatgt ctctccaccg
    18721 tcgtcctctg tgtacatgtt ccccaagtcc tcagggaaag cctctctaag agcatttact
    18781 agagccactt tcctgatcat ggtagctggc atggtgttcc atgtactttg tttcttgtca
    18841 tattcctcac gactgacaaa gatttccaca ggtaccttga aatttttgcg gtgcactcta
    18901 gcccatccgc ctatcagtgt atctcctggg agcatgattg cccctttgcg ttcgtgcata
    18961 acaccctcac tgtctactgc cactacccca gcctcaaagc cctcatagtc tttacattgg
    19021 gcggcacgtt tcaaaaaagc ctctttagag acaatcaagc taaactcttt gcccccatta
    19081 cggtttgtgt aagctacaat gtagacctcg ttagcaaatg ggttaagatt gcgaccttta
    19141 cacaaggcta gcgcctgacc tacttgtttt tcagtcagta ggttttgtgg gtcaaaatac
    19201 tttttgatgt ctgccccagt caataaactt gggtcagtag tgatgttacg ttttgtctgt
    19261 gttgctaatt gattattagt cattttcttc tctttttctt ttagtaatta aacattgtcc
    19321 cacagtatcc agcttcttct aatgctaatc ggttcaaata gtgtgacata tcgctaatac
    19381 tcatttttct aaccattttc tcggttagat aatcgccatc aatttcttct ctcattgcct
    19441 ctctaagttc ttgtttccat tttttgtaat ataatcgttt tttcatttct ttctaccttt
    19501 cgtcttcttc aaattccaat tttcacgctc taaatgctct ctattcatag gctaacaatc
    19561 tcctacatag atccattgac cagcgctgaa aatccaatca gctgggtcaa gttcttctcg
    19621 ttcttcaggc ggttgcatta tatctctgtc gtaatcaaac atgcgcatac acctttccaa
    19681 gttccagcac tcatttcaca tatctggcct ttgacgttag cccaagatcc agcaattcgt
    19741 ttttttcttc atgattagcc aaaagccata cacggttttc aagttcaatt ctagtcatct
    19801 tcctgctcca catcttcaat tttcacttcg ctatttagac gtttcatggc ttcatctacc
    19861 gacttgccgc ccaggacgtc cttgagcatg tggcttacat catgaaacga tttagctctg
    19921 gttcttcctt tttcgctatc aggaaccaaa ccgaggtctt gcataagtag gactgctacg
    19981 cttgcgtcgt gcatttcttt ctgaagctgt ttgatttttt tgattgtttt tagtgcttta
    20041 aacatattgt tctcctttta ttctcctact ttccaaattc ggcaacgtga ctcaatttct
    20101 ggtagttttt cattttgata aacccaatcg ttaccatgaa gacctgatgc gatgtaagat
    20161 atagatttta agtaatcaat cgcttcttct tttgtttcaa aaactcttgc aatatagtct
    20221 tggtgccccg tcggtaagaa atcacgtcca atcaaactga aatcctcgtt tccagtttca
    20281 gtattcttga cataaatcga tataatgtac atctacattt ctccttacag tctagcctta
    20341 atgtcaaaat tttctttgta cttgtaagca gcaagctcct gcttcaaatc gtagttttct
    20401 tgctcgaaag caaagcgacg tttgcgctct tcgaataggt cggtcatgag ttcgactgct
    20461 acctctctcc agtcaaggtt gactgattta agaactcctt caagtctgag ttttaattta
    20521 gtaagtagtt tcattaagct acgccctcct cgttagattg cttgttcatg cctaaaataa
    20581 tgtcatagta ggaatgacca gcagggatga catagcctgt caaatcatca acttgagaac
    20641 catctgccat gatgtttaca atccgtggct cccattcctt ttttactgtt ttcatgatat
    20701 aattacctcg taaagtattt tgcttagtcc ctcaatggaa ttgccgttcc agaggggctt
    20761 ttgtttttat cctgtcaagt attcctgatt aaggaactta ttgataaaat actgttgtcc
    20821 tttgcctgtg acctttggtg tcttgttcac agtgatatgt ccatctgcgt gttgcacgtt
    20881 tgtttccatg atttcaaaga gtttcaagtc catgctacgt tgggttggca cgttccaatc
    20941 tgagcctttg cgcttaatca ggtagccatt ttcgcgcatc caagaaaaga ggcgattggc
    21001 accgattttg tagccgtttt ggctaatgag cttggcaagt tcgccaacca agatagatgt
    21061 atggcttgca cttactgcgt ctgcaaatag caccttagga cggtcagcct caatctgagc
    21121 ctctagcttg tggactttct gatcagccat gagcaatgct cttgccatga ttttctcagg
    21181 gctattaaag tctttttcta cttggataaa gtattgtcgg acttgcttgc ctctctccgt
    21241 ccgctggatc atagcaattt ccttggccat gtctagcttg atgatgtggt caactttgtt
    21301 gtgaccccct cgtcctgttt gctgctcatt tttgagaagc aaaaaatctt gattttctgt
    21361 aaagccgtat tcaatcattc tattgaacca atcggcatat tttgttttga ctcccagagc
    21421 ttcatgaagt tgtcttccgg aaacaacagg ctcatgattg tcattcaggg ttacgttgat
    21481 gagttcgttc atagtattcc ttttattcct tcctcctatt gagttacttg agaagtatca
    21541 tgaatggctt catagctaag acgcttaaat tcttctgagt ctatctgaaa attgataggc
    21601 tttttttgta aacgctcaag aaaactagtg tttcttaaaa gtttttcaac taactcaggg
    21661 tctgccttca caaaggtgga ctcttttttc ccactatacg gatatcgtct tggtctcatt
    21721 tcctcacctc ctttgtattt attttttcta ccctctcttt tatttattta gagaagtagg
    21781 actggttgtc ttttaatatt tattgttatt taatacttgt tgttagttaa tatttattag
    21841 tgccttattt tacaacgttg taaaatgcaa ttttgtaaaa tacaatgttg taaaatgcaa
    21901 ctttgtatta agtaattgtg gataactcag acttcttcat agctatcgct tcatcaagac
    21961 gttgcaacat aatttcaaat tgaaaatcag ttatttttgt atctgagaag aatctgaaag
    22021 tctgaactcc tctccctctg ccgaggcttt ttttgacagt ccttaaatat ccagcttttt
    22081 caatcttttt gaaatgcctt aaaaccattt cgcggctaat attcaaccgt ctagctattt
    22141 cctctggata gacaagccaa ttctctttat tgctgagaac gaccatcaat atcccaattg
    22201 ttgccggctc aagctttgga tctctcagaa aatcattttt gactgcagtg taatcatccg
    22261 tcgcatttct gaaagattaa ttgaagattc aagtttttaa aatctgtcat aagttctcct
    22321 ttcttttcaa tctcaaattg agatatttta ttttaaaaaa ataattcact ctctgatttg
    22381 tgaaaataat tagaaataat agatatctca taatcatgga atggagcttt gccattttct
    22441 tttaattcat attgtctgcg atttttcaaa ccaattaaat ctgccataaa aactgtcgta
    22501 agttcatgct tctttctctc ttttctaagc tttattttcg gcttcaattc ttgctttttt
    22561 aacttttgtt tttttgtaag ttcctgcacg cactcacccc cttgtgttaa tagttgccct
    22621 gtcgtttcta gatagattgt tctaatcatt gacaggcttg gcttttaatt caaattcaat
    22681 aatactaagt cgatcgattg cttcttgcaa ttcttcggct ttttttgata cttctttaca
    22741 ggcttccttt agttcttcaa tacccgaaac ttcaacatta agccgatatc ctattggtct
    22801 catttctttc tcctttttga tataatgttt aataaaaacg aggtttgcta tgttaagtat
    22861 tgatacacaa tttgtagata caatcagtaa aatactatct gactatgttt cacattctga
    22921 aatcacaagg atgggagaag ttttaggata tccccaaaac gaccagaact ctggactcaa
    22981 taaacaccat agagttcaca atatcatgtc tgatatactc aacaaaacac aagataaatc
    23041 aaatatcaaa cttgtaattg agtatatctg caatcctttg aggtacatcg atacggtttc
    23101 agattttgaa aacttaagat taaaactaaa tgtcgttctt tccctaaaag gccttaccat
    23161 atcagatgac ggacatgtag ttattactac tgcttcacaa actttagttg aggcaaagaa
    23221 acgatttgaa tcacttgaac atatgttgag aacattaaat gttcatccaa atgttttaaa
    23281 attctgcacc caggaactct tacaagaaaa ttattttcat gctgtatttg aagcaagtaa
    23341 aggaatcttt caccgcattc gtttgctaac cggttcgtct ctggactcag caagtctaat
    23401 agaccaatgt tttaaaacca aagaacccat catgattatc aacggaaata aattacaaac
    23461 tctcgacgaa caaagtgaat ataaaggatt gaagaattta cttctgacaa tcgcacatct
    23521 ttatcgtaat tccaaagcac ataaacttaa atactacaat ccagatagcg ttcatgatgc
    23581 cttaactgcc ttaactctta tgtccctcgc tcacaatctc cttgacaact gcactaatac
    23641 taggagactt gattagtaga ttataaaatt ctatagtcac ctcagctaat ctaattgttt
    23701 cttcatctat gggactattg tagtcctcaa ggtgatgaag cctttcagtc aactgctctg
    23761 ataagtattc tgtttgccta aagatagatt tatgaagatg agtaattggt tttagcaaca
    23821 cgatttcatc ataagttaat attttttcag tctcctcttg agttacttct gctaattttt
    23881 ccataccaga aatatcaaca ttaacatgcg gctgttccat tatcgttccc cctcgtctta
    23941 ctttccagcg ccctgagttc tatctcatga ctgacttgaa gaaatagctt ctcacacgct
    24001 attttagctt ctctgtacgt tgtgttttcg ctgatgaagt aatcagcaag ttcaatgatt
    24061 ttatcttcca attctaacta cctttcaaat gtggtataat caaaataaaa cgattggaga
    24121 aatcttatat gcgaatcgaa gtgaaaacag actctaattt taaacaagag gtatttgtag
    24181 acaatatctg tccaaactgt tcaaaaccta ccaaccctca agtagtttct caaggatata
    24241 acgaaataat gccagggaaa gatagtatct atgtaacgct tcgttgttta ggttgttatc
    24301 attactgggt tgaagagttt gttagagaac ttgacagagg cggtttttat gatacgacgc
    24361 acataaaggt taagactcag ctacctagcg acatacctat ctccaatgat cttgaattga
    24421 tttcgccagt cggcaaggaa atctacgttc aatctctcaa agcagaacaa gaacatcttg
    24481 accttattgc aggtatcggt taccgtaaag ctttagagtt tttcgtcaaa gatttttcaa
    24541 ttcttacaaa tcctgataaa aaagagaaaa taacaaatat gcttttaaag caagttatcg
    24601 aagactatat cgaagatgaa gatcttaaaa cttttgcctt agcttctacc tacatcggaa
    24661 atgacgaagg acattactat cgtaaaaatc cagacaagaa tctcgccgac ttgaaaaagt
    24721 atattcatgg tgttatctac taccttgaaa agagactcat atttcttgac gctcaagaac
    24781 ttgtgaatcg ttcaacgaaa tcttagaatc tacttcatcc aacttctcag caatatatgt
    24841 cacagtcctc aatatctcgt tgagggctgt tctttctagt tcgttcatct tcccacctcc
    24901 ttgtcttttt tattttgctc ttggagcaac aacctgccaa ggattcgaac cttggtgata
    24961 ccaatcaggc tacatttaat ttatcaagca ttcctgcaaa tgctgcatca aaacgaatgt
    25021 catcgatttc ctcttgagtg aaaccagaat cgagaaggta acgctcttgg cgttcaatct
    25081 cctctgctaa ctctgtccat ccaaaagcga attgacggca gttagtacag aatgcttcaa
    25141 gctggctgta gaggaagttt tcctcgtaag taccttggat taaagtttcc ttagctactg
    25201 ctttgaagat gttgattgct ttctcgttta atgtgttcat ggtgtttccc tccggtttgt
    25261 ttttgttatt tccttaagct tgatttaatt atatctcatt ttgagatatt tgtcaataat
    25321 tttttatcac tttttgagat ttttttattt attttttggt cgcgttagta tataataaga
    25381 aatgaaagga gttgtttaat atgaatatac taggtagctc aattaaagaa gtaagaaaat
    25441 ccaagaaatt aactcaaaaa aaacttgccg agctgacagg ttttaaacaa aatacaattt
    25501 ctaaccatga aaacggaaat agacagttag atgaaaaaga tattagaata tacgctcagg
    25561 ctttagaagt ttctcctcaa tatctatttg acctagccaa accttcatct attgaaatta
    25621 tccctaccac ttccccaatc caaaccatct acgacgaact agaaccacct agacagggca
    25681 aagtcctgaa ttatgcaaag aggcaactga aagagcagag gaacgaagaa gaaacgaaga
    25741 taaacgaagt atcagaagct attcggctct acagttacga ctactacgac cacccagctt
    25801 ccgcaggtac aggccagtat ttgaatgatg tacgagtgga acggattgag ttaccagtag
    25861 atgttgatgc tgactttgtc atccccatca aaggtgactc catggagcct gactaccacg
    25921 atggtgacct ggtattcatt cagacaagtg tagatttgaa tgacggagtt atcggagtat
    25981 tcaactacaa cggcgatgct tatatcaagc agcttgttat tgatgaagac caggcttacc
    26041 tacatagcct aaaccctgaa tataaagata tgccaattac accagacacc gacttccgaa
    26101 ttatcggcga agtcgtggat ttgtataggg agaaataaca tgagtaacga aagtagaccg
    26161 atggaagtga ttaaacacaa cctagattgc aaatgccaca gacgaagaga gtggattaga
    26221 gtaaatgata aatggcatgc tatcgagttt tcggtagacg atccaaacga acctcctatg
    26281 acagaggaag agaaagccaa cgtggcctta attcttcaac aacacttatc gaaagaataa
    26341 aaccaactgt ttccaaaatg gaaataattg caaacaaaaa aagccccacg ctctcggtcg
    26401 gcaaacttct gagcgtgagg catgtgacag gaaaagattt tcatggagat aacctctcat
    26461 gatgtctttt cttgtaccca ttttatcatt ttttaggaaa ttttgaaaga ggtactacta
    26521 tgataacaac aaataaagta gctatatatg tcagggtatc gacgacaaac caggttgagg
    26581 agggatactc tatagatgag caaaaagaca agctctctag ctactgcgac attaaagact
    26641 ggaatgtata caaagtatat actgatggag gtttctcagg atccaatact gacagaccag
    26701 cgctagaaag tcttatcaaa gacgctaaaa aaagaaaatt tgacacagtt ctagtctata
    26761 agctggaccg tcttagccgt agtcaaaaag acacgcttca cttgattgag gatgtattca
    26821 tcaagaatgg gattgaattt ctgagcttgc aggagaactt tgacacctct actccttttg
    26881 gtaaggctat gattggactc ttgagcgtct ttgctcagct agaaagggag caaatcaagg
    26941 aacgcatgca acttggcaag ctaggacgtg ccaaatctgg taaatccatg atgtgggcta
    27001 agacatccta tggttacgat taccacaaag agacaggcac agtgaccatc aatccagctc
    27061 aggctctggc cattaagttt atctttgaga gttacctgag agggagatct attactaagt
    27121 tgagagatga tctaaatgag aaatacccaa agcatgtgcc ttggagctat cgggcggtca
    27181 gaaccatact cgataaccct gtctattgtg gtttcaatca gtataaggga gaaatttatc
    27241 caggtaatca tgagccgatt atttcaaaag aggaatacga taagactcaa tctgagctaa
    27301 aaataagaca aagaacagca gcagagaatg tcaatcctag accattccaa gctaagtaca
    27361 ttttatccgg tatcgcccaa tgtggatatt gtggcgctcc tttaaaaatt atgttaggcg
    27421 taaagaggaa agatgggagc aggttaaaaa aatatgaatg ccaccaaagg cacccacgaa
    27481 cgctgagagg cgttactacc tacaacgaca ataaaaagtg tgactcagga ttttactaca
    27541 aagacaagct agaggcctct gtgctaaaag aaataagcaa actacaagat gacgctgatt
    27601 acctggacaa aatattttca ggagacaatg ctgagaccat agaccgtgag agctataaga
    27661 aacaaataga ggagctatca aagaaactga gcagacttaa cgatctatac atagatgacc
    27721 gcattaccct tgaagaatta cagagcaagt cagccgaatt tataagcatg agggggactc
    27781 ttgaaactga actagaaaac gatccagcac tcaggaagaa caaaagaaag gctgatatga
    27841 ggaaactgct aaacgctgag aaagtctttt caatggacta cgaaaatcaa aaggtgcttg
    27901 ttagaaggct tataaacaag gttaaggtga cagctgagga cattgttatc aattggaaaa
    27961 tataaataat tttagtaacc tacatttcca ccaatgtaaa agctttaacc ttagcttttt
    28021 tcaagaatgt catcattttt ttcattttaa aaatttacct ccatattttg atacatgggc
    28081 atgagcattg ccgcataaag taaaacgata atcagtgcca caaaaataaa aaccagtggc
    28141 tgcaccaaat tcatggtgcg gttgactcgg gtaaaaaagg cttcccaagt tttttcagca
    28201 tagatttcca actcactacc cagcttggac ttaacttccc catactctat gatgagactc
    28261 aattccttcc taaagaaagg ataggttcct atcgtctgag aaaattcacg gccatttttc
    28321 agggtttgag ccagatcttg accgatttct ttaaagagct gggaaccttg ttcctgcatc
    28381 atttgaaaaa tctgcgtcag ctccattccc tgtgaaatca tattccccca ttcacgtgca
    28441 taataggctg tcaagtaggt ctgcacaaag attccaataa agggaaggcg tgctaagata
    28501 gaaaagacac tcatcttaga acttctttta taaaaagtta gtgctaaaag ggcaagcacg
    28561 gaaacaagcc ctaccatgcc tagaaaaatt tgtggcagat taccgataat tcgggtggca
    28621 atattgctac tatccagttg tgggagcagg taattccgta gccccagcat aattaagaga
    28681 agaaaaaaca gcaaaatcaa aggataggtc gctacttcaa ttaatttttt cttgaccttg
    28741 gccagattgt ctagatactc ttctatcttt cccaaactca ggtggagatt accatggact
    28801 tcagctaggg ataactgagt gacaatagca cttgaacatc ccaaactttt catcatttct
    28861 gagaatgatt tcccctgaga caagcccaca cgcatctggg tcacacactg cttgtccaac
    28921 aaagcactcc tatctaaaaa ggagatagtc tccaccagat gaaaaccgct agaaaagaga
    28981 ttgttaaata gggtgatgat atttttttgc ttagctgtag ctaatttttt ccgtctcagc
    29041 ctgaagactt gtgatatgtc catctttaag aagctggtca atttgctcat tccacttggc
    29101 tgcttggtgt tcttgataat ctctgcttgc aaagtcaacg attcctcctc ccccgattaa
    29161 tctctggtag cagactcctt gcagaacaac tgccaattct tcttcactca cacccaactc
    29221 cagcagacgc tcataaacac ctcggatact cttggcgtga atggttgaaa agactgtcgc
    29281 acctgtcaaa ctagctctga ccactgcacg cgccgtctcg ctgtcacgaa tttctccgat
    29341 aatcaagaga tctggtcgat gacgcaagga aagtttgatt agatttccat aggttaggcc
    29401 gattgcttcg ttcaactgca actgaagcat gtcgtcctgc ttgatttcga caggatcttc
    29461 gatggacata acttgctgtc ctttaaagag tgacttggac aattcatgca tcaaggtcgt
    29521 cttaccactc ccaaccggac cagcaaaaag atagagtccc cgttgcctgt actgcttgcc
    29581 taattcttca atatcctgaa accaaaaatg caagtcctgt tcctcatcgt gcaacaaacg
    29641 gataaccaaa ctctcatgcc cccgataatc gcctacagta gataaacgta gagacgccat
    29701 cttctggtca taggcataat cacaggaacc cagttgacta cgtctttttt ctcccacatt
    29761 catacccgcc acaaacttaa agtgactgat aacggctgca aacttttcaa aatcatagct
    29821 accaatttta cagcgctcgt ctcctaccct catatgaagc tcataggcgt ctaacttagg
    29881 gacaaaataa atatcctgcg tccctttttc ccgagctgaa cgaatgattt cttgtgcaat
    29941 ttcttgaacc atacttacct cctcacctat actattcgca aagagttaga aaaataaaaa
    30001 aagcaactcc aaaaaagtta cttttctcta ttttaatttc atacggcaag aacgattcct
    30061 ttcctgactg gtttgttttt catagcctga gcgtagtttt tcgtctggga taacctgctc
    30121 atcctgcaaa agagccaaag aatggtattg ttgtaaatac tcatcacatt catcacacca
    30181 gcgttggtct tccgggtccc aaaaaatggt catcaaatcg cttctacttt tataaagagg
    30241 ggattcttgt tccaatctaa accagcaagt tttgtagtat ttgagagcat cataatactg
    30301 atcaaatttt ctacttgcta caatatcttc ttcccaacct tctaagaacc accacggttc
    30361 aaaatctccg tacatttcta taacacgata catattcatt cattcctttg taccgtatat
    30421 tataaccaat tccgccagac aaggaaagaa atatgctcat ttctgaattt tttgataaaa
    30481 aatccagcca tctgatggat gactgaattt ctatttactt atgtacaaaa atatttttac
    30541 tacttaggct tctgagatat cgttttcgat aatgacctta atggcatggt ggtctgctgc
    30601 cttactgaag acttcgtagg ctttttcaat ttcactgagt ttgaaatagt gagttaccaa
    30661 tttttctggt tcaatcttat gactttcaag tgctttcaac aattgtggag tcgtatttgt
    30721 agataccaaa ccagttgtta cattgatgtt gcgaatccaa agtttatcta aatcgaattc
    30781 aactggttta ccatgcacac cacagttggc aaccgttccg tctacaccga taatcttttg
    30841 acagaaatca aatgttgcag gaataccaac agcttcgata gcgacatcca caccacgacc
    30901 atctgtcaaa tcataaattt ctttaatggc tttttcaggg tctgaagaat taaccttatg
    30961 agtcgcaccg aatgataggg cagtttccaa gcggttatcg tctaggtcta ccataatcaa
    31021 tttagctggt gaatagaatt gggctgttaa aagagcagcc aatccaactg gacctgaacc
    31081 aataatggct acgctgcaac caggttctac tttccctttt aagacaccaa tttcatatcc
    31141 agtaggcaga atgtctgaca gcataaccaa agcttcatct gacaagtctt ctggagtatg
    31201 gtaaagagta ttatctgcat gagggacacg tagatattca gcctgcatac catcaatcaa
    31261 gtgaccgaaa atccagcccc cttcgtcttc acagtgggca taaattcctt ttttacagta
    31321 gtagcattta ccacaggcac agacgcaaga aatcaagacc ttgtcacctt ttttgaagtt
    31381 ggaaactcct tccccaactt cttcaacaat cccaatccct tcgtggccaa gaatggtacc
    31441 actttggcaa gtaggaacat cccctttgat aatatggagg tctgttccac aaatagtggt
    31501 ttttacaata cgcacaatag cgtctgttgg cttgcgaata actggtttgt ctacatcaac
    31561 aaaagaagca agtcctggtt taacataagt ataagctttc ataaagcact cctccgtttt
    31621 tttatttgta ctatttatag ttcaattgta agcctttttc tttgtttctt caagcttttt
    31681 ttgtgatttt tttaactttt tatttaccag taaagtaccc tgcataaaaa agcagaagtt
    31741 agtctctaac ttctgctttc tctcttatgc ttgataacgt ttcacgccat ctaggtaggt
    31801 tgctaccaat tccaaatctt tatctaatac gatgaagtca gcgtcgtagc cttcacggat
    31861 ttggccacag acgtcatcga tgtgaacgga tttagctggg ttgaagctgg ccatcatgac
    31921 tgcttcatgc ggattcgcaa ttccccattc gaccacattc ttcaaaccat ctttgagttt
    31981 gaggatagaa cctgccaagt tacctgtcga tttgaggcgt gcagttccat ttgcaacgac
    32041 aactgggaat tctcccaaca tataatctcc gtcttccaat cccccagctg tcatacagtc
    32101 tgtgataaga gcgatgtttt ctgttccttt ttgtttgata agaatttcgc aagcctttgg
    32161 atctacgtgg tgaccatcac agatcaactc tgcataggta tgtggcaatt ggtacatggc
    32221 tccaaccata cccaattcac ggtgagtcaa cccacgcatt ccattgtagg catgcaccca
    32281 aacactcgct ccagcatcga ctgctttttt ggcttcatca aaagtcgcgt ttgaatgtcc
    32341 aagagcaacc gtcacacctt cgcccgtaac tgtacgaaca aagtcttcca ccccatcacg
    32401 ttctggtgca agggcaattt tattaagcaa gccatttgcc gctttttgcc aagaatgaaa
    32461 ctcctcaaca cccgggtctc tcatataagt tggattttgt gcccccttaa aagtttctgt
    32521 gaaatatgga ccttcataat aaatcccacg aatcttagca cctgttgctt ctttataatg
    32581 gtttccaaga ttttcagtga ctgcaagcaa ttgctcataa gtggctgtta aagttgtggg
    32641 taagaaactg gtaacaccgg tactaagaag tccttcactc atagtatgca atgtaccttc
    32701 aatgttgttg tccatcacat ctacacctgc atatccatga atatgagtat ccacaagacc
    32761 tggggcaatg ctataacctg tatagtcaat cacctcagcc ccttcaggaa tctgctctac
    32821 atgttttcca aacttgccgt ccacaagttc caagtaacca cctcgacgaa ctccgtgtgg
    32881 gtagaaaaac tgatccgctt taatatagtt aggcataatg ttaacctcct taaaagattg
    32941 attctacaat ttgttatatc aattacatta taaacctttc ttttttattt gtaaatggta
    33001 tatacctatt ttttggagat attttaaaag agctggattt ctccaactct tctctttttt
    33061 aatacaagtt attttgattt aaccggcttg tcttgagctg tctgcaaagc tgtggcaatc
    33121 gtatctgcat acaattttgc tcctgcttcg atagtgctac tctcactccc gaaatgaacc
    33181 tgatctgttc cagcccaaat ttctggatgc tctttcgcaa cttgattcca atctgctatc
    33241 gtaatgtaag gtgtcttctc tgccaattct ctcatatagg cagcagcctt ctcaacgatg
    33301 gcataggtct cttttgtctt atctccctca taaggagtca ccaaaatcat atggtgtccc
    33361 ttaggaagat ttttcacgat actgtcccag tcatccttgt agttctcagg attatttacc
    33421 ccagtcgcaa tgaccaccgt cttaggtaaa aatttattct ggctattatt tagcatgatt
    33481 tcatttgcgg tcttggttgt tacgctgacc tgcgcgttaa tctgtgctcc aggaagagct
    33541 gtctgtagtg ctgtatttgc ccttaaagcc actgagtcac caattaacat agtgccatca
    33601 gcaattccca aactgtttgc atctgcccgt tctgccatca ccttggtctg gccaatattt
    33661 gttgcagctt gcttcaagcc attgacagtc aagtctgtct caaacgctcc cacttgtggt
    33721 gccaacaagg tcaccatgca gacaatgaag gtcaagattc ctgtacctgc tgcaagaatt
    33781 gcgtgaatat aaggcagggg acgaagggtt tggacaatag gtgtgttctt gcctgcaatc
    33841 caaggttcca atacataaaa tgacagactg gcaaagccat aagaacaaat cagagtcagt
    33901 aatacagcaa gaagatttga tgtcaactgt gagaaaatga tatagaaagg ccaatggaaa
    33961 agataaaccg catagctagt atccgctaaa aagctgataa tcttcggctc ctgtatatga
    34021 tgtgtctttt catgtaagac acgcgccgcc agaatcatgg caagagctgc aagactggca
    34081 agcaagaagc cgataagata ggcaaaaaga taagtgaatt tgacaaagaa agtcaaaaga
    34141 actaggaaac caaagcctcc tccaaaaact accaaagtct ttcgtaaatc ccagatttta
    34201 tccaactgct tgacgaggga agtcgtctga cgaacgccta caatagttgc taacatactt
    34261 cccaaaaaga atggatagac atgagttaaa ctggagaaat aaacagagga ataagaggtc
    34321 actagaaaac taccaataaa catggagaag aaactgatca agaaggcagt agcagataag
    34381 agaaagatca tccccttcaa ctgaccattt gatttagctt gtttggataa gaaccaaact
    34441 gccaatcccc aaagaatata gtagtgaacc tcaactgcca aactccaatt atgaacaaac
    34501 aaatgaggaa tgaactgaga ttcataactc ccacctgtta agagttcata gaagttggtc
    34561 ataaagccta agacgcccgc aatctggcca ccaattccag caacatagtc ttggcgaacc
    34621 aagaaagtaa aaggcatggt caccaagacc atcaaaacca caggtggcac aatccgataa
    34681 aagcgtcttc taaaaaatcc tatcaaatca atctcattgt tcttagaaaa ttcttcaatg
    34741 agtagagctg taatcaggaa acctgaaaat gtgaaaaaga catctacccc gaaaaatcct
    34801 ccaggaaaga tcgtctgaaa gaagtgatac aagagtacca aaagtaaacc tataatccta
    34861 atcaaggaaa accatttaat gcgcatacga gtttattctt cctttcattg tacactttat
    34921 tctatcaaaa aaagaagaaa aatcctaaga gaaaacttag gatttttagc ttatatcaat
    34981 tccattttag aaattacgtc ctgacttatt atagccatat ttttccacaa aatacttacg
    35041 gaattccaag agattgtcat ccatgatggc ttgtcgcact tgcttcatca ggttaagcaa
    35101 gaagtaaaga ttgtggtagc tagtcaagcg gataccaaag gtttcatcag ccttgagcag
    35161 gtgacgaagg taagcgcgtg tatagttatt acatgtgtag caatcacact caggatccag
    35221 tggcgtaaag tcctcagcaa actgggcatt tttcacaacc aaacgtcctt gactggtcat
    35281 acaagtcccg ttacgagcaa ttcgagtcgg taagacacag tcaaacatat ccaccccacg
    35341 aatgacccca tcgatcaagc tatctggcgc tcccacaccc atcagataac gaggtttatt
    35401 ttcaggcagc agttgagttg taaagtccaa gaccgcattc atctcttcat gggtttctcc
    35461 cactgccaaa ccaccgatag agtagcctga gaaatccatg ctgacaagat cgtgagctga
    35521 ttggcggcga aggtcttcaa atcctgcacc ttgcacaatt ccaaacaaac cttggtcatg
    35581 tggacgacgg tgagccttca aaccacgctc agcccaacgg ctggtacgct cgatcgattt
    35641 cttaacgtag tcataaggtt gataaaactg aggacattca tcaaaggaca tcatgatgtc
    35701 tgaactcaga ttattctgaa tagagatggc tttttctggg gataggagca tcttagaacc
    35761 atttagatga tttttaaagg ttactccttc ttctgtgata ttacggctat ctgctaaaga
    35821 ataaacctga aaaccaccac tatctgtcaa gataggctgg tcccaattca tgaacttgtg
    35881 gagaccacca gcgcgtgcaa tgagttcatc tccagggcga agccagagat gataggtgtt
    35941 tgataggata attcccgaac ccatctcctt caattcttca ggtgactgag ttttgacagt
    36001 ggcttgtgtc ccaactggca taaacatagg tgtcggaaag gtaccgtggg gagtgatgat
    36061 ttctcctaga cgagctcctg tgtgtttttc tttcttaatc aaacgatatt tgattggtga
    36121 atctgacatt ttttacctcc gaagctggga aagacagtcc cagttcatac agtgtgccca
    36181 aggacacact gtatgatttt atcaaaaaaa gtaggaactg tcacgaacta tgtataagaa
    36241 ctatggtata ataagagaat gaactatcca aaaattgatt taaaaacaat tcgtcaggag
    36301 tcaaaacatt ttcaggctga caccccccgt ctctttctcc tctatatcct tcccagtatg
    36361 ctggtcatct tatctggttt tcttaatccc ttatctcgga tccacgggac tgttttagaa
    36421 cagccatttt tcagcatact tggccaaata cttcaaacct acctctttcc tctactagtc
    36481 tcctttatcg ggactattct tttgaccagt tccgtctatg caacactgac actcatgaaa
    36541 gattctaaaa cggagccatc tgtaaaaaac agcctagctc tctttgatga ggagcgcttt
    36601 tctcaaacct ttttgaccct acttctcaaa cgtttctatc tctttttatg gagtatccct
    36661 aatttacttg ggatttacct cctcttttat agtagctttt tagccaaaaa attcgtcacc
    36721 ctacatcctg agtttccaaa tctagatctc tcatcagttg aaaccgagcg tttcctcatg
    36781 gtctttggac tctactttct tgcaagtctc atcttgatca ttgtaggaaa tatcctctat
    36841 attccacagt attatgccta ttcacaggtg gaatttcttc tctgttatag tttagaccta
    36901 ggacaggtcc caccaagacg aatcctaaaa actagccgtt cctttatgaa gggctacaag
    36961 ttccagcact ttgtcctaga tttacagctt cttccttggt acttcctcaa ttggattacc
    37021 tttggcattg ctagtttttc actcctacct tatatccaat gcactaaaat tatgttttac
    37081 cgagcagtat tggctcgaaa acgtccaaaa gcttgaaggt tttcccctca agcttttttc
    37141 tatcaatgaa tttctccgcc taccaacttg agttcctgat ctccatgttc tatcatagcg
    37201 ccgattgctg cttctatccc tcgccgaata tccactaaac tcatagttgg agtagtcggt
    37261 ctgttcacca cctgttccat catataagga atatgcataa aacctgcctt aacatatgga
    37321 aatttctttt ctaccaaata gagagcctga tacatcaaat ggctgcagac aaaagtccct
    37381 gccgtattgg aaacagaggc cggtaatcct tattttttat agcttgaacc atcgctttaa
    37441 tcggcaaact actaaagtag gccgaagcac catctgggcg aatgggacgg tcaatcggtt
    37501 gattatcttc gttatcagaa atgcgtgcat cgtcttgatt aatggccact cgttcaggtg
    37561 tcaaactagt tcttccacca gcttgcccaa tacaaaggac aaagtcaggt tgataacgat
    37621 tcatctcttc ttccaatact tgagcagatt tgtgaaaaac tgtcggcacc tctagccaac
    37681 ggacctcagc accatggatt tcagctggta aacctttaat ggcctcaaaa gggctcaaaa
    37741 cctgtcacta atactttcat ttctaactcc tcaaaaccaa ttcaatgaaa cttttttctt
    37801 aaaaacaagt ataacatatt tcccttattc tggattaaaa aggattagcg agattagaat
    37861 cgaccttcaa gtgtatttaa agagtaaaat actaatcaag gccaaaatag ctgatccacc
    37921 ttgtttcaaa ataatttttt tatccgctgt taaagagccg taagtcgcag caccaatcac
    37981 aaataagaca aaaatagtca caatttctaa attctgtgag aaataaatga catacaagag
    38041 aaagactcct agcagagcct tataaatccc ttgatttttg aacaatgaac ttactgacgg
    38101 atgagccaat tcttcctttt ccatattaaa tacacgacta gtcgcatctg attgcgtggc
    38161 aatactttcc aaataaaaaa tgtaaaaatg ctccaaagca acgatcgttg ttaaaataat
    38221 tgtaataatt gacatctatt tctccttaaa tttctatatt ttcaataccc aaaaccaatt
    38281 tatttaataa acggctgagt tctgttctct caaactctgt taagatactt tccatctctt
    38341 ccttaacctt gatatgttgc agagggggat tcaccactaa ctgctccttg gcatacttcg
    38401 cagtctctac caacacttcc cgctgatttt caggattacg atgacgctcc accaaacctt
    38461 ccgtttccaa aatcttgaaa tgccgtgtca aagcagcctg atcaattttc aaacgctcct
    38521 gaaccgccat ttggttacaa ggagaatgct ccagcaaaaa cagtaaaatc tgataccgtg
    38581 tcaaactaat ccaagccttt tttcaaacaa ttgcgtactc gcttgctcag acaagcggag
    38641 ttgatacagt aaatcttgaa tctctagcat ttcttcccct ctctttttat tgatttatca
    38701 atatttgact aatcacgtat aatgcaaagt aaaatagatt gcaagaatgt tacttaactc
    38761 attacaatat ggtaacttcc cattttccat tcaaattgat actcaatgaa aatcaaagag
    38821 caaactagga agctagtcgc aggttgctca aagcacagct ttgaggtttc atataaaact
    38881 gacgtggttt gaagagattt tcgaagagta tgacaaagaa aaaacgaacg agaatcgctt
    38941 tccatcacga aagctagatc tcattcgtca aaatgatgtt atcaagtcgg gtttatccat
    39001 tcattgaaac gtgaacgtga tcatagtgat tttctgtcac actaccacgg tctggcattg
    39061 ggttccaagt gttagctggc ccatatttgc tatcgaatgg agcatagaaa cgttgtttcc
    39121 agatgatgta actaatgcca cggctggcca tgttttgaat agcatattcc gcaatcttat
    39181 cccctaattc tgaacgttct gctaccataa agtcgatagc caaacctttt ccgtgatctc
    39241 cactgtctcc tggacgataa ccactaaagg atgtaatgcc aaacaagtta gcaatttctt
    39301 ctttaaaggc agctgtttgt ggttgaagac ctgcattttc agattttgct actgcaagtc
    39361 cagcataatc gggcgcagct ggtgcctcgt aagttgttga aattactttc gtttcttctg
    39421 gttgataagt agaaactgct gctgtagctc catttgatga tgctacttct tttgcttctg
    39481 aacttgttgt agttgcttcc actgctgatg cagcttgagg gcttgcttgt gtttcctgct
    39541 tcttagctgg agtcgtttcc tgaggagttg cttcttcaac tgggcgagtt gtttcggccg
    39601 tttgctcctc tgggacagaa gtgcccgtag atggtgccac ttcttcagaa gcaatcactg
    39661 tctttgtaac ttctgaactt gatgctactt cttttggagc ttctgcaatc ggttgagaaa
    39721 ggtctgcaac ctgaacagtt tgaacatcaa cggtcacttg attagtggtc aaatctgctg
    39781 tcgcagttgt cacttcttca ctagagtctg cttgaggtgt ttggatttca acttctgtta
    39841 cttcttctgc ttcattgaca gtcgttgtca aaacagtttc tgggaaaatc aagtccatat
    39901 tagtgatttt gttcagattc gcaagcactg tgacatctac acccaaggct tctgcaatgg
    39961 tgctcaaagt atcaccatac tgtacggtat aacttgtttt gttgtccgtt ttagtcaaat
    40021 cgttttggat ttgctcaaca ctacgtgcag tccaaagaac ttcttctgct tgagttgcca
    40081 atactggggc aaatgacaag gctactgttg acgctaataa cattcttttc ttcattcttt
    40141 caaattcctt tcaaatgagt acctgtctat cataacacaa aaaatgtaga aaaaaagccc
    40201 tctcgggcct atttaacaga actgtctatt ccttgtaaca aactaggtta cttgaaatag
    40261 tttgttaggt ctctgtcaca aaactgacac aatcttttta tcacttagtc tcaaaaatac
    40321 gggaaatatc tgctaacgct tgaatcctgt gattcccttc ataagtagac tctaaaaagt
    40381 tgatactttg aatcccacta ttctgggcaa attccacatc cagagtccga tcccctatat
    40441 aataagtatt atcagaattc aactgatact tatctagcag ataggtagcc gcttctggac
    40501 ttggcttccg cacaaagcca ctctgactgg ttaaaatctc tgtaaaatag gattccaccc
    40561 ccaagtcctt gagaatggta aaagcgttgt tccccttatg agtatatata aactgctgaa
    40621 ttcctgattc gtctgcccaa gctagcacct cacgcgcacc tggcatcaaa actacctgag
    40681 cattcttctc agccagactc tgggcacgca cctgatttag cacctcaaca tccagatttc
    40741 tatcttctgc cacccgcaca agcaaatctt gcaccgaata cttgaagata aactctctca
    40801 ccttctcctt atcataagga atagaaaact gagcaaaagt ctcctcaatc cctgataaaa
    40861 tcgcttcgta agagtccaat aaagtcccgt ctaaatccca aataaaagct gttttttgca
    40921 tttcctatcc tttcaagctc atatagcgct ggtaacgata gcgtagaaat aaccagcgaa
    40981 aaccattatc caagagagac cctgcccaaa taccaggcaa gccccaacca agcacaatcc
    41041 ccatcagata tcctgtccca atgcggatac accacattcc tatacttgtc gcataaaaag
    41101 ggaggcgtgc atttcctaat ccctgccaga ctgccgtata gatgactgtt cctgtcgtca
    41161 taggggtccc aagtagtgaa aacagtgtca ctagaacact agcctccacc gctagagaat
    41221 cagtcgtata gagatgagtt aatggtacac ccaagacata tatactaaag gacaggggca
    41281 acatgaggaa cagagaaagc caaaaggttt gtttactcaa actagcaact cttttccaat
    41341 catcctctcc aactgctcgg gccaacagca tgaccgttgc cgtagcgacg ccaaaggcag
    41401 gcatatagtt aaactgggtc aagacttctc cgattgcatt cccagcaact gcctccgtcc
    41461 caaaagaaac gaccaaggca atgatcacta catctccagc cctcatcata agtcgctctc
    41521 cagctgctgg taaagccaag gtcaacagtt ccttatctaa accaaaagtt ggcttcccat
    41581 aaggcagttt taattgtgac cacaaaatca caagaccaac caaacgagac acaattgtcc
    41641 cccaagcaac accagctatc cccatatcca gaacaaaaat agctagactt gaaaaaagaa
    41701 tattcaaggc attggataaa aaactaacat agagaggcag acgtggatta tgcgttgcac
    41761 gaatcaaggc tcctagacta gtcattaaac ctaagagaac aatcgatccg cctaccaaag
    41821 atagatacag tccaccactc tcagctacat ccctctccgt ccccaaaagt cctatcatct
    41881 ctttcccagc gaagatggac aaaaatccta aaaggaaact taatagtaag gtaatcttca
    41941 acgcctcagt cacatgatag gccaacttcg actggtcttt ctgccctatg ctttttgaaa
    42001 taacactgga aatagcagct cccagagcga tgaaaatcgc ctgataaatg gtgataatat
    42061 taccagctac tgaaacccct gaaatagcta tcaatcctaa atgagcaacc aaataactgt
    42121 ccaccattcc cattagcatc tgcaaaaagt tttcacccat agctggcaat gcaatattaa
    42181 gaatgtcttt atttttctta aacaatctct cctcctgatg aaaagaaact cagttggttt
    42241 cccaaccgag tttgctccct ctgtcttaaa gtcctaaata agcctcaacc gctgcttgca
    42301 tgtcagcagc tgccactgtt gtcttgtgac gaattggagc tatttcaagc ccatcaactg
    42361 ctggtggcac tgcaacgcct gagatttcat gtaattgagc caaggcttca aagtctgtta
    42421 aacctgcttt tccagttaca gcttctactg caactactgg gaacttgtat ggactagctg
    42481 ttgaagcaat cactgtctta gttacatctc cagtggccga ttggtatttt ttataaactg
    42541 ctgaagcaac agctgtatga gggtcctcga tataagaatc taactcacaa acacgcttga
    42601 tctctgctgc cgtttcttcc tcagtcgcat attcagctgc aaagaggtcc aaaatctctg
    42661 catcaaagtc tgtcaactta tattgtcctt gcgtgttcaa ggcattcata agttcagttg
    42721 tcttttcagc attatttccc aaaagatgga aaatcaagcg ctccaagttt gaagatacca
    42781 agatatccat agatgggctg gttgttacct taaactcacg ttttttgtca tagacacgtg
    42841 ttttaaagaa gtctgtcaaa acattgttgt catttgaagc acagattaat ttaccaactg
    42901 ggagaccgat ttgtttggca taaaaggcag ccaagatatt tccaaagttt cctgttggta
    42961 ctgtgaagtt aatcttatca ccagccacga tctcaccagt cttgaccaac tgagcatagg
    43021 cataaacata ataaacaatc tgtggcacca aacgaccgat attcatagag ttagcagatg
    43081 aaaattgcaa cttgttggcc gctaatcttt cacgaagagc cacgtcgtta aacatgtgct
    43141 tcacgttggt ttgtgcatcg tcaaagttac catctatagc gataacatga gtattgtcac
    43201 cattctgagt ggtcatttgc aactcttgta ccttgctgac accacccttt ggataaaaga
    43261 cgataatctc agtaccaggc acatccgcaa accccgccat agcagctttc cccgtgtcac
    43321 cagatgtcgc tgtcaagata acaatcttgt tctccaaacc atgtttctta gcagcagtcg
    43381 tcataaagta tggcaaaata gacaaggcca tatccttaaa ggcaatcgtt gaaccatgga
    43441 aaagttccaa attgtattgc ccatctaatt tcactaatgg tgcaatagct ggagtatcaa
    43501 atttgctatc gtaggcattg ttgatacagt agtccaactc ctcagctgta aagtcatcta
    43561 aaaatgctga caaaactagc ttagcaactt cctggtaaga agcatctttc aatttgtcaa
    43621 agttcaaatc tacctttgga taagtaaccg gtgtaaacaa accgccgtcc gtcgccaaac
    43681 cttgcaaaat tgcttggctg gcagttactg tattgttggc atcacgcgtt gattgataaa
    43741 ctaatgtcat tactctctat cctttatcta tagtctcgtc cattatatca tgatttttca
    43801 gaaaattctc cctttataag agaaattata ggctcaattc ttctctcaaa ggctgtaaat
    43861 aggtcatttc ttccttattt ctcaccacta gtccctcctc agctagtagg agtaagtctt
    43921 tggaaaattc aataatcgta gtttcttcct catctgtaag atttttctta gaaaattgtc
    43981 tccttaaaga cttgtaatca taaccaaata ctttaaagaa aggtgctgtt tctaagtaag
    44041 cttctaactt gtctaaatta accaataatc ccaagtgaaa agctgcagaa gcaaaagtcc
    44101 tatcaagtgg ctgtgtacac acactacgaa actcaactgt tcctcgagtc gttaagtctt
    44161 ggtactggta actacgatga gtttcaaaat ccttctcttg gggggaaata ataacctcat
    44221 ccccattcag agcaaatgct tggatttcag gcgtagccaa atagtcccca gcctgaatag
    44281 gataaaaata ataggtctgc ccatcacgtt ccgcagtaaa aatcgcagaa tgatttagat
    44341 agtcaaaaaa atcagcttca tcattaagga gtctagcatt gaccccaaca ttctctggat
    44401 agataccatg catagattct tcccagaaaa tatcccttga aattttcgta tcccaatccg
    44461 cacccgaaaa ctcagagttt gcaaataaat aagccttagc cgcttcaatt tgagtaaaag
    44521 cattaatcac ccgtaagtag ttggtttttg aaatatccag ctgaacctgg ctcccacaga
    44581 taaaagtacc atattcaggg aaatgatgta aatctgattt aataatattt ctactcaaat
    44641 tcaaataatc catcaacatc tgatagcgtg gataagccac tggacaattc tcatttttat
    44701 cccagttggg atggatacca cagccaacaa tagcatgatt tgattcagct aacttcttct
    44761 ggattgcttc catataaata ctaaaacgtt cttcaacttc ttgtatcgtt tcagccttac
    44821 caaatgcaaa ctcaatcgtt gtataggaaa cttcaaataa aatagcatcc tgacttatcg
    44881 gatctactaa ctggatcaaa ttgccaaaat catctacctt tgctacggtg agatccaaag
    44941 tagaaactaa ataatgaaat agatccttta taacttcaac atctgtagca tccccttcta
    45001 aacttgcaac aggatactcc aactcaattc cgacaaacaa ttcaggattt tctttaatat
    45061 ttttcaaata ccgatgtttt aataaatcga tagaacaaga catactaccc tacactttct
    45121 taatctaaat aaaatttgaa taactataat tataccaaaa ataatataaa aaaggaacga
    45181 agaataacaa cgttcctaac actatactat accggcggcc ggggtcgaac cggcacgtcc
    45241 ttgcggacac tggattttga gtccagcgcg tctgccaatt ccgccacgcc ggcaaatagt
    45301 aactggggta gctggattcg aaccaacgca tgagggagtc aaagtccctt gccttaccgc
    45361 ttggctatac cccaatataa aataggcgag tgatggggat cgaacccacg catgccagag
    45421 ccacaatctg gtgtgttaac cacttcacca cacccgccat aattctatta acacgggcag
    45481 taggaattga acccacactg aaggttttgg agaccttagt tctaccttta aactatgccc
    45541 gtaaaatgga aggggaggga ttcgaacccc cgaacccgaa ggagcggatt tacagtccgc
    45601 cgcgtttagc ctcttcgcta cccttccaaa atatataaat ggcgcgagac ggaatcgaac
    45661 cgccgacaca tggagcttca atccattgct ctaccaactg agctaccgag ccttattgcg
    45721 ggagcaggat ttgaacctac gaccttcggg ttatgagccc gacgagctac cgagctgctc
    45781 catcccgcgt taataatata aaaggaggat gtgggattcg aacccacgca cgcttttaca
    45841 cgcctgacgg ttttcaagac cgttcccttc agccggactt gggtaatcct ccaaaatagt
    45901 ttatacggga acaagcccgt gtcctcttag tgaacagata atattccaat cccctagtaa
    45961 tggactaaac actatgggca cgagtggact cgaaccaccg acctcacgct tatcaggcgt
    46021 gcgctctaac cacctgagct acgcgcccaa gttaaaaaac ttggtaattt gaacaaagtt
    46081 caaagcgggt gacgagaatc gaactcgcga caacagcttg gaaggctgta gttttaccac
    46141 taaactacac ccgctaaa
//
LOCUS       DAVLHC010000013        45592 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.013, whole genome shotgun sequence.
ACCESSION   DAVLHC010000013 DAVLHC010000000
VERSION     DAVLHC010000013.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 45592)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 45592)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..45592
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.013"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            224..2884
                     /gene="rrgA"
                     /locus_tag="VXE25_000797"
     CDS             224..2884
                     /gene="rrgA"
                     /locus_tag="VXE25_000797"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000757844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PI-1 pilus tip adhesin RrgA"
                     /protein_id="HEV0771290.1"
                     /translation="MKKVRKIFQKAVAGLCCISQLTAFSSIVALAETPETSPAIGKVV
                     IKETGEGGALLGDAVFELKNNTNGTTVSQRTEAQTGEAIFSNIKPGTYTLTEAQPPVG
                     YKPSTKQRTVEVEKNGRTTVQGEQVENREEALSDQYPQTGTYPDVQTPYQIIKVDGSE
                     KNGQHKALNPNPYERVIPEGTLSKRIYQVNNLDDNQYGIELTVSGKTVYERKDKSVPL
                     DVVILLDNSNSMSNIRNKNARRAERAGEATRSLIDKITSDPENRVALVTYASTIFDGT
                     EFTVEKGVADKNGKRLNDSLFWNYDQTSFTTNTKDYSYLKLTNDKNDIVELKNKVPTE
                     AEDHDGNRLMYQFGATFTQKALMKADEILTQQARQNSQKVIFHITDGVPTMSYPINFN
                     HATFAPSYQNQLNVFFSKSPNKDGILLSDFITQATSGEHTIVRGDGQSYQMFTDKTVY
                     EKGAPAAFPVKPEKYSEMKAVGYAVIGDPINGGYIWLNWRESILAYPFNSNTAKITNH
                     GDPTRWYYNGNIAPDGYDVFTVGIGINGDPGTDEATATSFMQSISSKPENYTNVTDTT
                     KILEQLNRYFHTIVTEKKSIENGTITDPMGELIDLQLGTDGRFDPADYTLTANDGSRL
                     ENGQAVGGPQNDGGLLKNAKVFYDTTEKRIRVTGLYLGTGEKVTLTYNVRLNDQFVSN
                     KFYDTNGRTTLHPKEVEKNTVRDFPIPKIRDVRKYPAITIAKEKKLGEIEFIKINKND
                     KKPLRDAVFSLQKQHPDYPDIYGAIDQNGTYQNVRTGEDGKLTFKNLSDGKYRLFENS
                     EPAGYKPVQNKPIVAFQIVNGEVRDVTSIVPQDIPAGYEFTNDKHYITNEPIPPKREY
                     PRTGGIGMLLFYLIGCMMMGGVLLYTRKHP"
     gene            3107..5104
                     /gene="rrgB"
                     /locus_tag="VXE25_000798"
     CDS             3107..5104
                     /gene="rrgB"
                     /locus_tag="VXE25_000798"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000836217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PI-1 pilus major pilin RrgB"
                     /protein_id="HEV0771291.1"
                     /translation="MKSINKFLTMLAALLLTASSLFSAATVFAAGTTTTSVTVHKLLA
                     TDGDMDKIANELETGNYAGNKVGVLPANAKEIAGVMFVWTNTNNEIIDENGQTLGVNI
                     DPQTFKLSGAMPATAMKKLTEAEGAKFNTANLPAAKYKIYEIHSLSTYVGEDGATLTG
                     SKAVPIEIELPLNDVVDAHVYPKNTEAKPKIDKDFKGKANPDTPRVDKDTPVNHQVGD
                     VVEYEIVTKIPALANYATANWSDRMTEGLAFNKGTVKVTVDDVALEAGDYALTEVATG
                     FDLKLTDAGLAKVNDQNAEKTVKITYSATLNDKAIVEVPESNDVTFNYGNNPDHGNTP
                     KPNKPNENGDLTLTKTWVDATGAPIPAGAEATFDLVNAQTGKVVQTVTLTTDKNTVTV
                     NGLDKNTEYKFVERSIKGYSADYQEITTAGEIAVKNWKDENPKPLDPTEPKVVTYGKK
                     FVKVNDKDNRLAGAEFVIANADNAGQYLARKADKVSQEEKQLVVTTKDALDRAVAAYN
                     ALTAQQQTQQEKEKVDKAQAAYNAAVIAANNAFEWVADKDNENVVKLVSDAQGRFEIT
                     GLLAGTYYLEETKQPAGYALLTSRQKFEVTATSYSATGQGIEYTAGSGKDDATKVVNK
                     KITIPQTGGIGTIIFAVAGAVIMGIAVYAYVKNNKDEDQLA"
     gene            5169..6350
                     /gene="rrgC"
                     /locus_tag="VXE25_000799"
     CDS             5169..6350
                     /gene="rrgC"
                     /locus_tag="VXE25_000799"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010963222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PI-1 pilus minor pilin RrgC"
                     /protein_id="HEV0771292.1"
                     /translation="MISRIFFVMALCFSLVWGAHAVQAQEDHTLVLQLENYQEVVSQL
                     PSRDGHRLQVWKLDDSYSYDNRVQIVRDLHSWDENKLSSFKKTSFEMTFLENQIEVSH
                     IPNGLYYVRSIIQTDAVSYPAEFLFEMTDQTVEPLVIVAKKADTVTTKVKLIKVDQDH
                     NRLEGVGFKLVSVARDGSEKEVPLIGEYRYSSSGQVGRTLYTDKNGEIVVTNLPLGTY
                     RFKEVEPLAGYTVTTMDTDVQLVDHQLVTITVVNQKLPRGNVDFMKVDGRTNTSLQGA
                     MFKVMKEENGHYTPVLQNGKEVVVASGKDGRFRVEGLEYGTYYLWELQAPTGYVQLTS
                     PVSFTIGKDTRKELVTVVKNNKRPRIDVPDTGEETLYILMLVAILLFGSGYYLTKKTN
                     N"
     gene            6689..7585
                     /gene="srtC-1"
                     /locus_tag="VXE25_000800"
     CDS             6689..7585
                     /gene="srtC-1"
                     /locus_tag="VXE25_000800"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PI-1 pilus system sortase SrtC-1"
                     /protein_id="HEV0771293.1"
                     /translation="MAKTKKQKRNNLLLGVVFFIGIAVMAYPLVSRLYYRVESNQQIA
                     DFDKEKATLDEADIDERMKLAQAFNDSLNNVVSGDPWSEEMKKKGRAEYARMLEIHER
                     MGHVEIPAIDVDLPVYAGTAEEVLQQGAGHLEGTSLPIGGNSTHAVITAHTGLPTAKM
                     FTDLTKLKVGDKFYVHNIKEVMAYQVDQVKVIEPTNFDDLLIVPGHDYVTLLTCTPYM
                     INTHRLLVRGHRIPYVAEVEEEFIAANKLSHLYRYLFYVAVGLIVILLWIIRRLRKKK
                     RQSERALKALKEATKEVKVEDE"
     gene            7578..8471
                     /gene="srtC-2"
                     /locus_tag="VXE25_000801"
     CDS             7578..8471
                     /gene="srtC-2"
                     /locus_tag="VXE25_000801"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000370515.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PI-1 pilus system sortase SrtC-2"
                     /protein_id="HEV0771294.1"
                     /translation="MSKSRYSRKKSVKKKKNPFILLLIFLVGLAVAMYPLVSRYYYRI
                     ESNEVIKEFDETVSQMDKAELEERWRLAQAFNATLKPSEILDPFTEQEKKKGVSEYAN
                     MLKVHERIGYVEIPAIDQEIPMYVGTSEEILQKGAGLLEGASLPVGGENTHTVVTAHR
                     GLPTAELFSQLDKMKKGDIFYLHVLDQVLAYQVDQIVTVEPNDFEPVLIQHGEDYATL
                     LTCTPYMINSHRLLVRGKRIPYTAPIAERNRAVRERGQFWLWLLLGAMAVILLLLYRV
                     YRNRRIVKGLEKQLEGRHVKD"
     gene            8458..9309
                     /gene="srtC-3"
                     /locus_tag="VXE25_000802"
     CDS             8458..9309
                     /gene="srtC-3"
                     /locus_tag="VXE25_000802"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000091736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PI-1 pilus system sortase SrtC-3"
                     /protein_id="HEV0771295.1"
                     /translation="MSRTKLRALLGYLLMLVACLIPIYCFGQMVLQSLGQVKGHATFV
                     KSMTTEMYQEQQNHSLAYNQRLASQNRIVDPFLAEGYEVNYQVSDDPDAVYGYLSIPS
                     LEIMEPVYLGADYHHLGMGLAHVDGTPLPLDGTGIRSVIAGHRAEPSHVFFRHLDQLK
                     VGDALYYDNGQEIVEYQMMDTEIILPSEWEKLESVSSKNIMTLITCDPIPTFNKRLLV
                     NFERVAVYQKSDPQTAAVARVAFTKEGQSVSRVATSQWLYRGLVVLAFLGILFVLWKL
                     ARLLRGK"
     gene            complement(9382..10658)
                     /locus_tag="VXE25_000803"
                     /pseudo
     CDS             complement(9382..10658)
                     /locus_tag="VXE25_000803"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436393.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
     gene            complement(10773..10922)
                     /locus_tag="VXE25_000804"
     CDS             complement(10773..10922)
                     /locus_tag="VXE25_000804"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000359822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771296.1"
                     /translation="MDKMKPVFQALNKELIQENLTLTIICVDGYVLEYHGLRATQDVD
                     AFMAL"
     gene            complement(10915..11199)
                     /locus_tag="VXE25_000805"
     CDS             complement(10915..11199)
                     /locus_tag="VXE25_000805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002923859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771297.1"
                     /translation="MDWYDYMIQASKQSQFNASHWFRYLRKVIFEDYSYLTNQDVEKL
                     LDSKELTRFQKISLKYAFQEHTPTHKYVISLNKPAKLTNVQKLMEKYKHG"
     gene            complement(11811..11981)
                     /locus_tag="VXE25_000806"
     CDS             complement(11811..11981)
                     /locus_tag="VXE25_000806"
                     /inference="COORDINATES: protein motif:HMM:NF024172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEV0771298.1"
                     /translation="MTKQVPKFTKDTAQLYTCKWLLYNKVTKMYDHTVVNHSVREYIT
                     DSISTNTIEKAG"
     gene            complement(12798..14021)
                     /locus_tag="VXE25_000807"
     CDS             complement(12798..14021)
                     /locus_tag="VXE25_000807"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000628995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family transcriptional regulator"
                     /protein_id="HEV0771299.1"
                     /translation="MITKQSAFLQNRATILEFLYRNPATSRTDIVNETGLTPATTTNI
                     IKELSEQSLIYETGDEFSEFSGSGRRRKTISITDNIPYVVGGIEINVLGIFLSLCDLQ
                     GKTLFETEILNEDYPISEINSTITNMIKTAIEYVPLETKLLGFGLSIPGHYNKDSGSI
                     ITNNPIWESFNLLNVIKRFNFPFIVKNNIDCMAIGQYLFNPHNTPDNFIFLHAGLGIY
                     TSFFTKEKIGASKNPYIGEIGHTIVELNGQYCECGKKGCLQTYISDAWLIKHAQLLFK
                     NSQLTVLKSLVKTEKDIHLDTLLTAYNLGDSALRQQIDKGVNLLATSIANLLLINPAD
                     KIYINSQLLNYQPFTHEVRDKIQDQLHFVPFTRNIEIEILPYNKHRGSIGACALAIVA
                     FFIEHSNVLQDIISP"
     gene            14189..15511
                     /locus_tag="VXE25_000808"
     CDS             14189..15511
                     /locus_tag="VXE25_000808"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001059752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HEV0771300.1"
                     /translation="MNNILAFLETKVAPFGEKVGNQRHLKAIREGFMMAMPLILVGSL
                     FLILISWPQEDFTNWLNSVGLLSILTTMNQSTVAIISLVACFGIAYRLSEGYGTDGPS
                     AGIIALSSFVLMAPRFSSMVYDKNGEQVKQLFGGAIPFSSLNASSLFMAITIGLVTAE
                     IYRMFIQRGITIKMPSGVPDVVSKSFSALLPGFTTFVLWALVLKGLEAAGVAGGLNGL
                     LGAIVGTPLKLIAGTLPGMILCVIVNSFFWFCGVNGGQVLNAFVDPVWLQFTTENQEA
                     VAAGQTLQHIITLPFKDLFVFIGGGGATIGLAICLFLFSKSRANKTLGKLAIIPSIFN
                     INTAILFTFPTVLNPIMLIPFIATPTINALITYVSMVVGLVPYTTGVILPWTMPPIIG
                     GFLATGASWRGALLQVVLILVSVAIYYPFFKIADKRNLEKEKATVGGK"
     gene            15513..17399
                     /locus_tag="VXE25_000809"
     CDS             15513..17399
                     /locus_tag="VXE25_000809"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000236922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4838 domain-containing protein"
                     /protein_id="HEV0771301.1"
                     /translation="MVIRVFDKQKNTYSSFALEELSYYINRVFKTDIELVEEKEADIF
                     VGLVNKEDRRDHVLISLDKGKGRIESNTIVGLLIGIYRMFHEFGVVYTRPGRGHDFVP
                     ELRFEDFLDKQLSIDETASYYHRGVCIEGADSFENILDFIDWLPKIGMNSFFIQFENP
                     YSFLKRWYEHEFNPYLNKEQFSNELVQELSDRLDKELQKRGLIHHRVGHGWTGEVLGY
                     SSKFGWESGLSISEEKKPYVAEISGKRELFNTAPILTSLDFSNPDVADKMVEIIKDYA
                     KKRPDVNYLHVWLSDARNNICECENCRQELVSDQYIRILNQLDRALTSEGLDTKICFL
                     LYHELLWAPQKEKLDNPERFTMMFAPITRTFEMSYADVDFDNSIPTPKPYLRNKIILP
                     NSLEENLSYLFEWQKTFKGDSFVYDYPLGRAHYGDLGYMKISQTIYRDVSYLSNLHLN
                     GYISCQELRAGFPHNFPNYVMGEMLWKKTRSYEELIEEYFSALYGENWQSVVEYLEKL
                     SIYSSCDYFNAIGSRQSDVLANHYYIAYNLADNFLPIIEENISKLLNSQKDEWKQLSY
                     HREYVVKMAKALYLQATGKTRQAQDEWRNVLNYIRGHELLFQSNLDVYRVIEVAKNYA
                     GFHL"
     gene            17567..17911
                     /locus_tag="VXE25_000810"
     CDS             17567..17911
                     /locus_tag="VXE25_000810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000836781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HEV0771302.1"
                     /translation="MKSKEEINMLGFTIVAYAGDARSDLMDALAFARDGYFEQARELV
                     ESANDSIVSAHREQTNLLAEEAYGDNFEVSFIMIHGQDTLMTTMLLYDQVKFFIDEYE
                     RIRKIEEHIGLQ"
     gene            17921..19333
                     /gene="lacG"
                     /locus_tag="VXE25_000811"
     CDS             17921..19333
                     /gene="lacG"
                     /locus_tag="VXE25_000811"
                     /EC_number="3.2.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000429433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-galactosidase"
                     /protein_id="HEV0771303.1"
                     /translation="MENLQVKALPKEFLLGAATAAYQVEGATRVDGKGTNMWDVYLQE
                     NSPFLPDPASDFYYRYEEDIALAAEHGLQALRLSISWVRIFPDIDGEPNILAVRYYHR
                     VFQSCLKHNVIPFVSLHHFDSPQKMLETGDWLNRENIDRFIRYARFCFQEFTEVKHWF
                     TINELMSLAAGQYIGGQFPPNHHFQLSEAIQANHNMLLAHALAVLEFHQLGIEGEIGC
                     IHALKPGYPIDGQKENILAAKRYDVYNNKFLLDGTFLGYYSDDTLFHLNQILEANNSS
                     FIIEDGDLEIMKRAAPLNTMFGMNYYRSEFIREYKGENRQEFNSTGIKGQSSFKLNAL
                     GEFVKKPGIPTTDWDWNIYPQGLFDMLLRIKEEYPQHPVIYLTENGTALKEVKPEGEN
                     DIIDDSKRIRYIEQHLHKVLEARDRGVNIQGYFIWSLQDQFSWANGYNKRYGLFFVDY
                     ETQKRYIKKSALWVKGLKRN"
     gene            19403..21082
                     /locus_tag="VXE25_000812"
     CDS             19403..21082
                     /locus_tag="VXE25_000812"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000359733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HEV0771304.1"
                     /translation="MDKLVAAIEKQQGKFEKISTNNYMMAIKDGFIATMPLIMFSSFL
                     MIIIMIPKNFGVELPSPAIAWMRKVYMLTMGVLGVIVSGTVAKSLAGNVNRKMPPGKV
                     INDTSAMLAAICGYLVLTVTLVVDEKTGSTSLSTNYLGSQGLITSFVSAFITVNVYRF
                     CIKRDITIHLPKEVPGAISQAFRDIFPFSFVLLISGLLDIVSRFSLDVPFAQVFQQLL
                     TPIFKGAESYPAMMLIWFMCALLWFVGIHGPSIVLPAVTALQLSNMEENAQLLANGQF
                     PYHSLTPNFGNYIAAIGGTGATFVVPFILIFFMRSKQLKSVGKATITPVLFAVNEPLL
                     FGMPVILNPYLFVPFLMTPPVNVFLGKVFIDFFGMNGFYIQLPWAFPGPLGLLIGTNF
                     QSISFVFLSLILVVDILIYLPFCRAYDRQLLMKEYVASSNDIILEEETSEIMPGEIDV
                     IKSKELKVLVLCAGSGTSAQLANAINEGAQLAEVRVIANSGAYGAHYDIMGVYDLIIL
                     APQVRSYYREMKVDAERLGIQIVATRGMEYIHLTKNPSKSLQFVLEHYQAV"
     gene            complement(21209..22648)
                     /locus_tag="VXE25_000813"
     CDS             complement(21209..22648)
                     /locus_tag="VXE25_000813"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TrkH family potassium uptake protein"
                     /protein_id="HEV0771305.1"
                     /translation="MNKSMIRYLLSKLLLIEAVLLLVPVAIAVYYRESSQVFTALFST
                     IGILVLLGGSGSLQKPKNQRIYAKEGVLIVALCWILWSFFGGLPFVFSGQIPSLIDAF
                     FEISSGFTTTGASILNDVSVLSRSLLFWRSFTHLIGGMGVLVFALAIMDNAKNSHLEV
                     MKAEVPGPVFGKVVSKLKNTAQILYLLYLALFSLFVIIYYLAGMPLYDSFVIAMGTAG
                     TGGFTVYNDGIAHYGSSLITYLVSIGVLVFGVNFNLYYYLMLRRIKAFFGDEELRAYL
                     VIVLVSTGLISLNTLYLYPGFSKSFEMTFFQVSNIITTTGFGYGDITNWPLFSQFILL
                     FLMAIGGSAGSTAGGLKIIRGLILSKIAKNQILSILSPHRVLTLHVNKTVIDKDTQHK
                     ILKYFVIYAMILLALIFIVSLDSNDFLVVTSAVFSCFNNIGPILGTTSSFSIFSPISK
                     ILLSFAMIAGRLEIYPILLLFMKRTWSKR"
     gene            complement(22652..24001)
                     /gene="trkA"
                     /locus_tag="VXE25_000814"
     CDS             complement(22652..24001)
                     /gene="trkA"
                     /locus_tag="VXE25_000814"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Trk system potassium transporter TrkA"
                     /protein_id="HEV0771306.1"
                     /translation="MKIILVGGGKVGFALCRSLVAEKHDVLLIEQDEAVLNHIVSRFD
                     IIGILGNGADFAILEQASVQDCDIFIALTEHDEVNMIAAVLAKKMGAKETIVRVRNPE
                     YSNSYFKEKNILGFSLIVNPELLAARAIANIIDFPNALSVERFAGGRVSLMEFVVKST
                     SGLCQMPISDFRKKFGNVIVCAIERDHQIIIPSGDMTVQDKDRIFVTGNRVDMILFHN
                     YFKSRAVKSLLIVGAGRIAYYLLGILKDSRIDTKVIEINPEIASFFSEKFPNLYIVQG
                     DGTAKDILLEESAQHYDAVATLTGVDEENLITSMFLDRVGVQKNITKVNRTSLLEIIN
                     APDFSSIITPKSIAVDTIMHFIRGRVNAQYSDLQAMHHLANGQIETLQFHIKEANKMT
                     AKPLSQLKLKKGVLIAAIIRKGKTIFPTGEDMLEVGDKLLVTTLLPNITKIYDLIAR"
     gene            24189..25037
                     /locus_tag="VXE25_000815"
     CDS             24189..25037
                     /locus_tag="VXE25_000815"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-adenosyl-l-methionine hydroxide
                     adenosyltransferase family protein"
                     /protein_id="HEV0771307.1"
                     /translation="MNNNLLVLQSDFGLVDGAVSAMIGVALEESPTLKIHHLTHDITP
                     YNIFEGSYRLFQTVDYWPEGTTFVSVVDPGVGSKRKSVVAKTAKNQYIVTPDNGTLSF
                     IKKHVGIVAIREISEVANRRQNTEHSYTFHGRDVYAYTGAKLASGHITFEEVGPELSV
                     EQIVELPVVATIIEDHLVKGAIDILDVRFGSLWTSITREEFYKLEPEFGDRFEVTIYH
                     ADMLVYQNQVVYGKSFADVRIGQPILYINSLYRLGLAINQGSFAKAYNVGVGSSWTIE
                     IKKIEG"
     gene            25052..25600
                     /locus_tag="VXE25_000816"
     CDS             25052..25600
                     /locus_tag="VXE25_000816"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000403170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF-type riboflavin transporter
                     substrate-binding protein"
                     /protein_id="HEV0771308.1"
                     /translation="MEIKFTIKQVVAVGIGAALFVVIGMINIPTPVPNTSIQLQYAVQ
                     ALLSIIFGPIIGLLVGLIGHAIKDSLAGYGLWWTWIIASGLFGLVVGLFRKYVRVING
                     VFDWKDILIFNLIQLLANALVWGVLAPLGDVVIYQEAAEKVFAQGIVAGIANGVSVAI
                     AGTLLLLAYAGTQTRAGSLKKD"
     gene            25607..25864
                     /locus_tag="VXE25_000817"
     CDS             25607..25864
                     /locus_tag="VXE25_000817"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771309.1"
                     /translation="MKIKEQTRKLAAGCSKQCFEIVDRTDEVSSKHGFEVVDETDEVS
                     NHTYGKAKLTWFEEIFEEYKMMGKAGQLVFFDVYRLVRQVS"
     gene            25966..27648
                     /locus_tag="VXE25_000818"
     CDS             25966..27648
                     /locus_tag="VXE25_000818"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000656554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0771310.1"
                     /translation="MKEAIIEWKDFSFRYETQQEPTLQGIDLTIYKGEKVLIVGPSGS
                     GKSTLGQCLNGIIPNIYKGQTYGEFLIKGQTAFDMSIYDKSHLVSTVLQDTDGQFIGL
                     SVAEDLAFALENDVTALDEMKGRVYKWAEKLDLLPLLDQRPQDLSGGQKQRVSLAGVL
                     IDESPILLFDEPLANLDPKSGQDIIELIDQIHKEEGTTTLIIEHRLEDVLHRPVDRIV
                     LINDGRILFNGSPDQLLATDLLTQNGIREPLYLTTLRQLGVDLVKEEQLADLDNLSIS
                     KGQIQLQTELVKETPALQSLFILEEVSFSYNDRPILKSLHLDIKKGEKIAIVGKNGAG
                     KSTLAKAISSFIQTEGRYLWEKQDIKGDSVAERAERVGYVLQNPNQMISTNMIFDEVA
                     LGLRLRGVNEKEIETRVYETLKICGLYEFRNWPISALSFGQKKRVTIASILVLGAEII
                     LLDEPTAGQDQKNYTEIMEFLEELHQQGHTIVMITHDMQLMLDYSDRALVMVDGELIA
                     DTVPASLLSDPELLVKANLKETSIFNLAKKLDVDPLDLTAFYKERREGCKLN"
     gene            27633..28463
                     /locus_tag="VXE25_000819"
     CDS             27633..28463
                     /locus_tag="VXE25_000819"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     protein EcfT"
                     /protein_id="HEV0771311.1"
                     /translation="MQAKLIGYQHRDTVIHRLSGAGKLLFFILVSLATMISYDTRMLL
                     LIAIFSVFLLYLSEIRFKDVSFVAVFATVFAVLNVLMVYLFSPEYGVGLYGERSVIWQ
                     GIGVYTLTSQELFYLLNLAIKYLCTIPLAIIFLMTTHPSQFASSLNQIGVPYKIAYSV
                     SLTLRYIPDLQEEFFTIKMSQEARGMELSKKASLMQRIKGNLLIITPLIFSSLERIDT
                     IATAMELRRFGKEKKRTWYSYQTLKKGDYITLLLATLFLVASLLLILQNQGRFYNPWK
                     "
     gene            28656..29159
                     /locus_tag="VXE25_000820"
     CDS             28656..29159
                     /locus_tag="VXE25_000820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000181367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (cytidine(34)-2'-O)-methyltransferase"
                     /protein_id="HEV0771312.1"
                     /translation="MTNHIVLFEPQIPQNTGNIARTCAATNSPLHIIKPMGFPIDDRK
                     MKRAGLDYWDKLEIYFYESLEDFISQMKGKLYLISKFAEKVYSEVDLSTDEDHYFLFG
                     REDKGLPEDFMREHPEKALRIPMNDEHVRSLNVSNTVCMIVYEALRQQNFAGLELVHT
                     YEVDKLK"
     regulatory      29213..29447
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
     gene            29612..30175
                     /locus_tag="VXE25_000821"
     CDS             29612..30175
                     /locus_tag="VXE25_000821"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HEV0771313.1"
                     /translation="MTNTRRLSTIAILSAISFVLMYFDFPLLPAASFLKIEFSILPVL
                     VGLVVMDLPAALGVLLLRSLLKLLLNSQGVNTYIGLPMNIVALGVFVIVFALIWKKER
                     TTLRFLLGSLAGTIGLTLAMLVLNYVYAVPLYAKFANFDIGKILGFSNYLMTMVLPFN
                     LIEGVIFSVSFWLLYVLLKPTLKHYER"
     gene            30189..30815
                     /locus_tag="VXE25_000822"
     CDS             30189..30815
                     /locus_tag="VXE25_000822"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001853067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatase PAP2 family protein"
                     /protein_id="HEV0771314.1"
                     /translation="MKGSFALLLFVILGYMVKFYPEMLVNFDQSIQTAIRGDLPDYLT
                     ILFRALTRLIDIPVIITWVVITAFVFYRKRWKIESFFMLGNLALAGLLIVTFKNIYQR
                     PRPAILHLVEEKGFSFPSGHSLAVTLMVGTLIVILSQRIKDQVWRKIVQIVLGLYLVS
                     VLVSRVYLGVHYPSDVLASLCVGLGVLFIEFPFYDKLRFQWRFKGKQK"
     gene            30842..31231
                     /locus_tag="VXE25_000823"
     CDS             30842..31231
                     /locus_tag="VXE25_000823"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000867286.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosome partitioning protein ParB"
                     /protein_id="HEV0771315.1"
                     /translation="MKVNIADLHPTQLYLSEKKLQDIQMLYQSAETIQVDPISILAFG
                     DCLLITDGHHRAYQALLAGRDTISAEWDRDGGDELYHFYAQACEERKIYSVFDLEDRI
                     LAQDGYEAKWYNWCDGFNQAATLLLKR"
     gene            31236..31684
                     /locus_tag="VXE25_000824"
                     /pseudo
     CDS             31236..31684
                     /locus_tag="VXE25_000824"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000333655.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
     gene            31812..32399
                     /locus_tag="VXE25_000825"
     CDS             31812..32399
                     /locus_tag="VXE25_000825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418402.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit delta"
                     /protein_id="HEV0771316.1"
                     /translation="MELEVFAGQEKSELSMIEVARAILELRGRDHEMHFSDLVNEIQN
                     YLGTSNSDIREALPLFYTELNFDGSFISLGDNKWGLRSWYGVDEIDEEIIALEENDDD
                     EVAPKAKKKRVNAFMDGDSDAIDYNADDPEDEDAYEADPALSYDDENPDDEKNEVEAY
                     DAEINEIAPDDLGEDVDLNEDDDEFSDDDAETSEE"
     gene            32789..34396
                     /locus_tag="VXE25_000826"
     CDS             32789..34396
                     /locus_tag="VXE25_000826"
                     /EC_number="6.3.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000105234.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CTP synthase"
                     /protein_id="HEV0771317.1"
                     /translation="MSTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPY
                     INIDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLRK
                     ERRGEYLGATVQVIPHITDALKEKIKRAALTTDSDVIITEVGGTVGDIESLPFLEALR
                     QMKADVGADNVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPA
                     GQGIKNKLAQFCDVAPEAVIESLDVEHLYQIPLNLQAQGMDQIVCDHLKLDAPAADMT
                     EWSAMVDKVMNLKKQVKISLVGKYVELQDAYISVVEALKHSGYVNDAEVKINWVNAND
                     VTAENVAELLSDADGIIVPGGFGQRGTEGKIQAIRYARENDVPMLGVCLGMQLTCIEF
                     ARHVLGLEGANSAELAPETKYPIIDIMRDQIDIEDMGGTLRLGLYPSKLKRGSKAAAA
                     YHNQEVVQRRHRHRYEFNNAFREQFEAAGFVFSGVSPDNRLVEIVEIPENKFFVACQY
                     HPELSSRPNRPEELYIAFVTAAVENSN"
     gene            complement(34955..36586)
                     /locus_tag="VXE25_000827"
     CDS             complement(34955..36586)
                     /locus_tag="VXE25_000827"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004251733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Na/Pi cotransporter family protein"
                     /protein_id="HEV0771318.1"
                     /translation="MSINWQEILFHFLGGLGLFLYSIKTMGDGLQQAAGDRLRFYIDK
                     YTSNPFFGVLVGIGMTALIQSSSGVTVITVGLVSAGLLTLRQAIGIVMGANIGTTVTS
                     FLIGFKLGNYALPMLFIGAVCLFFTKNRTVNNIGRILFGVGGIFFALNLMSGAMAPLK
                     DLQVFKDYMIELSKNPVLGVFVGTGLTLLIQASSATIGILQNLYAGDLIDLQGALPVL
                     FGDNIGTTITAIIASLGANIAAKRVAGAHVAFNVIGTVVCVIFLVPFTVLIHWFETTL
                     NLAPEMTIAFAHGTFNITNTIIQFPFIGALAYFVTKIIPGEDEVVKYEPLYLDEHFIK
                     QAPSIALGNAKKELLHLGNYAAKAFDLSYKYIIDLDEKVAEKGHKTEEAINTIDEQLT
                     RYLIALSSEALSQKESEVLTNILDSSRDLERIGDHTEALLNLTDYLQRKNVEFSDAAL
                     KELEEVYRQTSDFIKDALDSVENNDIEKARSLVERHEAINKIERVLRKTHIKRLNKGE
                     CSTQAGVNFIDIISHYTRVSDHAMNLAEKVFAEQI"
     gene            36875..41815
                     /locus_tag="VXE25_000828"
     CDS             36875..41815
                     /locus_tag="VXE25_000828"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000795197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacterial Ig-like domain-containing protein"
                     /protein_id="HEV0771319.1"
                     /translation="MKNPFFERRCRYSIRKLSVGACSLMIGAVLFAGPALAEETAVPE
                     NSGANTELVSGESEHSTNEADKQNEGEHTRENKLEKAEGVATASETAEAASAAKPEEK
                     ASEAVAETPSAEAKPKSDKETEAKPEATNQGDESKPAAEANKTEKEVQPDVPKNTEKT
                     LKPKEIKFNSWEELLKWEPGAREDDAINRGSVVLASRRTGHLVNEKASKEAKVQALSN
                     TNSKAKDHASVGGEEFKAYAFDYWQYLDSMVFWEGLVPTPDVIDAGHRNGVPVYGTLF
                     FNWSNSIADQERFAEALKQDADGSFPIARKLVDMAKYYGYDGYFINQETTGDLVKPLG
                     EKMRQFMLYSKEYAAKVNHPIKYSWYDAMTYNYGRYHQDGLGEYNYQFMQPEGDKVPA
                     DNFFANFNWDKAKNDYTIATANWIGRNPYDVFAGLELQQGGSYKTKVKWNDILDENGK
                     LRLSLGLFAPDTITSLGKTGEDYHKNEDIFFTGYQGDPTGQKPGDKDWYGIANLVADR
                     TPAVGNTFTTSFNTGHGKKWFVDGKVSKDSEWNYRSVSGVLPTWRWWQTSTGEKLRAE
                     YDFTDAYNGGNSLKFSGDVAGKTVQDVRLYSTKLEVTEKTKLRVAHKGGKGSKVYMAF
                     STTSDYKFDDADAWKELTLSDNWTNEEFDLSSLAGKTIYAVKLFFEHEGAVKDYQFNL
                     GQLTISDNHQEPQSPTSFSVVKQSLKNAQEAEAVVQFKGNKDADFYEVYEKDGDSWKL
                     LTGSSSTTIYLPKVSRSASAQGTTQELKVVAVGKNGVRSEAATTTFDWGMTVKDTSLP
                     KPLAENIVPGATVIDSTFPKTEGGEGIEGMLNGTITSLSDKWSSAQLSGSVDIRLTKP
                     RTVVRWVMDHAGAGGESVNDGLMNTKDFDLYYKDADGEWKLAKEVRGNKAHVTDITLD
                     KPITAQDWRLNVVTSDNGTPWKAIRIYNWKMYEKLDTESVNIPMAKAAARSLGNNKVQ
                     VGFSDVPAGATITVYDNPNSQTPLATLKSEVGGDLASAPLDLTNQSGLLYYRTQLPGK
                     EISNVLAVSVPKDDRRIKSVSLETGPKKTSYAEGEDLDLRGGVLRVQYEGGTEDELIR
                     LTHAGVSVSGFDTHHKGEQNLTLQYLGQPVNANLSVTVTGKDEASPKTILGIEVSQEP
                     KKDYLVGDSLDLSEGRFAVAYSNDTMEEHSFTDEGVEISGYDAQKTGRQTLTLHYQGH
                     EVSFDVLVSPKAALNDEYLKQKLAEVEAAKNKVVYNFASPEVKEAFLKAIEAAEQVLK
                     DHETSTQDQVNDRLNKLTEAHKALNGQEKFKEEKTELDRLTGEVQELLAAKPNHPSGS
                     ALAPLLEKNKALVEKVDLSPEELTTAKQSLKDLVALLKEDKPAVFSDSKTGVEVHFSN
                     KEKTVIKGLKVERVQASAEEKKYFAGEDAHVFEIEGLDEKGQDVDLSYASIVKIPIEK
                     DKKVKKVFFLPEGKEAVELAFEQTDSHVIFTAPHFTHYAFVYESAEKPQPAKPAPQNT
                     VLPKPTYQPASDQQKAPKLEVQEEKVAFHRQEHENAEMLVGEQRVIIQGRDGLLRHVF
                     EVDENGQRRLRSTEVIQEAIPEIVEIGTKVKTVPAVVATQEKPAQNTAVKSEEASKQL
                     PNTGTADANEALIAGLASLGLASLALTLRRKREDKD"
     gene            41905..43101
                     /locus_tag="VXE25_000829"
     CDS             41905..43101
                     /locus_tag="VXE25_000829"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001096748.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglycerate kinase"
                     /protein_id="HEV0771320.1"
                     /translation="MAKLTVKDVDLKGKKVLVRVDFNVPLKDGVITNDNRITAALPTI
                     KYIIEQGGRAILFSHLGRVKEEADKAGKSLAPVAADLAAKLGQDVVFPGVTRGAELEA
                     AINVLEDGQVLLVENTRYEDVDGKKESKNDPELGKYWASLGDGIFVNDAFGTAHRAHA
                     SNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEK
                     ADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKALLEKANGKLILPVDSKEANAF
                     AGYTEVRDTEGEAVSEGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQAG
                     TIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGL
                     AALTEK"
     gene            43237..43764
                     /locus_tag="VXE25_000830"
     CDS             43237..43764
                     /locus_tag="VXE25_000830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000119911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aromatic acid exporter family protein"
                     /protein_id="HEV0771321.1"
                     /translation="MSYFKKYKFDKSQFKLGMRTFKTGIAVFLVLLIFGFFGWKGLQI
                     GALTAVFSLRESFDESVHFGTSRILGNSIGGLYALVFFLLNTFFHEAFWVTLVVVPIC
                     TMLTIMTNVAMNNKAGVIGGVAAMLIITLSIPSGETILYVFVRVLETFMGVFVAIIVN
                     YDIDRIRLFLEKKEK"
     gene            43841..44197
                     /gene="glnR"
                     /locus_tag="VXE25_000831"
     CDS             43841..44197
                     /gene="glnR"
                     /locus_tag="VXE25_000831"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000659547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor GlnR"
                     /protein_id="HEV0771322.1"
                     /translation="MKEKEFRRNMAVFPIGSVMKLTDLSARQIRYYEDQELIKPDRNE
                     GNRRMYSLNDMDRLLEIKDYISEGYNIAAIKKKYAEREAKSKKAVSQTEVRRALHNEL
                     LQQGRFASVQSPFGRG"
     gene            44234..45580
                     /gene="glnA"
                     /locus_tag="VXE25_000832"
     CDS             44234..45580
                     /gene="glnA"
                     /locus_tag="VXE25_000832"
                     /EC_number="6.3.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I glutamate--ammonia ligase"
                     /protein_id="HEV0771323.1"
                     /translation="MPITAADIRREVKEKNVTFIRLMFSDILGTMKNVEIPATDEQLD
                     KVLSNKVMFDGSSIEGFVRINESDMYLYPDLDTWTVFPWGDENGSVAGLICDVYTTEG
                     EPFAGDPRGNLKRALRHMEEVGFKSFNLGPEPEFFLFKLDENGDPTLEVNDKGGYFDL
                     APTDLADNTRREIVNVLTKMGFEVEASHHEVAVGQHEIDFKYDEVLRACDKIQIFKLV
                     VKTIARKHGLYATFMAKPKFGIAGSGMHCNMSLFDAEGNNAFFDPNDPKGMQLSETAY
                     HFLGGLIKHAYNYTAIMNPTVNSYKRLVPGYEAPVYIAWAGRNRSPLVRVPASRGMGT
                     RLELRSVDPMANPYIAMAVLLEVGLYGIENKIEAPAPIEENIYIMTAEERKEAGITDL
                     PSTLHNALKALTEDEVVKAALGDHIYTSFLEAKRIEWASYATFVSQWEIDNYLDLY"
BASE COUNT        14054 a         7804 c        10073 g        13661 t
ORIGIN      
        1 ctatactata ttgtatacaa gtgtgtcatt gccaggttga gaagatagct ataacgcact
       61 tttatacgct tttgctacgt ttgttagtga acggattaac tcagtgagat aaattttatc
      121 agaacataag taatccgttt cttcgtgtat acagattgaa agtacctatg aatcatagaa
      181 ggattaactt gttctatgaa taatgcttaa cagggagaca cacatgaaaa aagtaagaaa
      241 gatatttcag aaggcagttg caggactgtg ctgtatatct cagttgacag ctttttcttc
      301 gatagttgct ttagcagaaa cgcctgaaac cagtccagcg ataggaaaag tagtgattaa
      361 ggagacaggc gaaggaggag cgcttctagg agatgccgtc tttgagttga aaaacaatac
      421 gaatggcaca actgtttcgc aaaggacaga ggcgcaaaca ggagaagcga tattttcaaa
      481 cataaaacct gggacataca ccttgacaga agcccaacct ccagttggtt ataaaccctc
      541 tactaaacaa cggactgttg aagttgagaa gaatggtcgg acgactgtcc aaggtgaaca
      601 ggtagaaaat cgagaagagg ctctatctga ccagtatcca caaacaggga cttatccaga
      661 tgttcaaaca ccttatcaga ttattaaggt agatggttcg gaaaaaaacg gacagcacaa
      721 ggcgttgaat ccgaatccat atgaacgtgt gattccagaa ggtacacttt caaagagaat
      781 ttatcaagtg aataatttgg atgataacca atatggaatc gaattgacgg ttagtgggaa
      841 aacagtgtat gaacgaaaag ataagtctgt gccgctggat gtcgttatct tgctcgataa
      901 ctcaaatagt atgagtaaca ttcgaaacaa gaatgctcga cgtgcggaaa gagctggtga
      961 ggcgacacgt tctcttattg ataaaattac atctgatcca gaaaataggg tagcgcttgt
     1021 gacttatgct tccactatct ttgatgggac cgagtttaca gtagaaaaag gggtagcaga
     1081 taaaaacgga aaacgattga atgattctct tttttggaat tatgatcaga cgagttttac
     1141 aaccaatacc aaagattata gttatttaaa gctgactaat gataagaatg acattgtaga
     1201 attaaaaaat aaggtaccta ccgaggcaga agaccatgat ggaaatagat tgatgtacca
     1261 attcggtgcc acttttactc agaaagcttt gatgaaggca gatgagattt tgacacaaca
     1321 agcgagacaa aatagtcaaa aagtcatttt ccatattacg gatggtgtcc caactatgtc
     1381 gtatccgatt aattttaatc atgctacgtt tgctccatca tatcaaaatc aactaaatgt
     1441 attttttagt aaatctccta ataaagatgg aatactatta agtgatttta ttacgcaagc
     1501 aactagtgga gaacatacaa ttgtacgcgg agatgggcaa agttaccaga tgtttacaga
     1561 taagacagtt tatgaaaaag gtgctcctgc agctttccca gttaaacctg aaaaatattc
     1621 tgaaatgaag gcggttggtt atgcagttat aggcgatcca attaatggtg gatatatttg
     1681 gcttaattgg agagagagta ttctggctta tccgtttaat tctaatactg ctaaaattac
     1741 caatcatggt gaccctacaa gatggtacta taacgggaat attgctcctg atgggtatga
     1801 tgtctttacg gtaggtattg gtattaacgg agatcctggt acggatgaag caacggctac
     1861 tagttttatg caaagtattt ctagtaaacc tgaaaactat accaatgtta ctgacacgac
     1921 aaaaatattg gaacagttga atcgttattt ccacaccatc gtaactgaaa agaaatcaat
     1981 tgagaatggt acgattacag atccgatggg tgagttaatt gatttgcaat tgggcacaga
     2041 tggaagattt gatccagcag attacacttt aactgcaaac gatggtagtc gcttggagaa
     2101 tggacaagct gtaggtggtc cacaaaatga tggtggcttg ctaaaaaatg caaaagtgtt
     2161 ctatgatacg actgagaaaa ggattcgtgt aacaggtttg taccttggaa cgggtgaaaa
     2221 agttacattg acttataatg ttcgcttgaa tgaccaattt gtaagcaata aattctatga
     2281 cacgaatggt cgaacaaccc tacaccctaa ggaagtagaa aagaacacag tgcgcgactt
     2341 cccgattcct aagattcgtg atgtgcgaaa atatccagca attacgattg caaaagagaa
     2401 aaaacttggt gaaattgagt ttattaagat caataagaat gataaaaaac cactgagaga
     2461 tgcggtcttt agtcttcaaa aacaacatcc ggattatcca gatatttatg gagctattga
     2521 tcaaaatggc acttatcaaa atgtgagaac aggtgaagat ggtaagttga cctttaaaaa
     2581 tctgtcagat gggaaatatc gattatttga aaattctgaa ccagctggtt ataaacccgt
     2641 tcaaaataag cctatcgttg ccttccaaat agtaaatgga gaagtcagag atgtgacttc
     2701 aatcgttcca caagatatac cagcgggtta cgagtttacg aatgataagc actatattac
     2761 caatgaacct attcctccaa agagagaata tcctcgaact ggtggtatcg gaatgttgct
     2821 attctatctg ataggttgca tgatgatggg aggagttcta ttatacacac ggaaacatcc
     2881 gtaaagtgta gaaatgataa tatctatgtt ctgaacgata cttttaagaa gtagcactca
     2941 agaagagatt taagtttact tggtgaaacc agttttcttc gccaagtaaa ccaccattga
     3001 aaggggagat gttttcgaaa acttgcacag aaaaaggatt attattgtca tgtgtaattc
     3061 attacattgc tcacagttga ttttaagaga taaataagga gaaatcatga aatcaatcaa
     3121 caaattttta acaatgcttg ctgccttatt actgacagcg agtagcctgt tttcagctgc
     3181 aacagttttt gcggctggga cgacaacaac atctgttacc gttcataaac tattggcaac
     3241 agatggggat atggataaaa ttgcaaatga gttagaaaca ggtaactatg ctggtaataa
     3301 agtgggtgtt ctacctgcaa atgcaaaaga aattgccggt gttatgttcg tttggacaaa
     3361 tactaataat gaaattattg atgaaaatgg ccaaactcta ggagtgaata ttgatccaca
     3421 aacatttaaa ctctcagggg caatgccggc aactgcaatg aaaaaattaa cagaagctga
     3481 aggagctaaa tttaacacgg caaatttacc agctgctaag tataaaattt atgaaattca
     3541 cagtttatca acttatgtcg gtgaagatgg agcaacctta acaggttcta aagcagttcc
     3601 aattgaaatt gaattaccat tgaacgatgt tgtggatgcg catgtgtatc caaaaaatac
     3661 agaagcaaag ccaaaaattg ataaagattt caaaggtaaa gcaaatccag atacaccacg
     3721 tgtagataaa gatacacctg tgaaccacca agttggagat gttgtagagt acgaaattgt
     3781 tacaaaaatt ccagcacttg ctaattatgc aacagcaaac tggagcgata gaatgactga
     3841 aggtttggca ttcaacaaag gtacagtgaa agtaactgtt gatgatgttg cacttgaagc
     3901 aggtgattat gctctaacag aagtagcaac tggttttgat ttgaaattaa cagatgctgg
     3961 tttagctaaa gtgaatgacc aaaacgctga aaaaactgtg aaaatcactt attcggcaac
     4021 attgaatgac aaagcaattg tagaagtacc agaatctaat gatgtaacat ttaactatgg
     4081 taataatcca gatcacggga atactccaaa gccgaataag ccaaatgaaa acggcgattt
     4141 gacattgacc aagacatggg ttgatgctac aggtgcacca attccggctg gagctgaagc
     4201 aacgttcgat ttggttaatg ctcagactgg taaagttgta caaactgtaa ctttgacaac
     4261 agacaaaaat acagttactg ttaacggatt ggataaaaat acagaatata aattcgttga
     4321 acgtagtata aaagggtatt cagcagatta tcaagaaatc actacagctg gagaaattgc
     4381 tgtcaagaac tggaaagacg aaaatccaaa accacttgat ccaacagagc caaaagttgt
     4441 tacatatggt aaaaagtttg tcaaagttaa tgataaagat aatcgtttag ctggggcaga
     4501 atttgtaatt gcaaatgctg ataatgctgg tcaatattta gcacgtaaag cagataaagt
     4561 gagtcaagaa gagaagcagt tggttgttac aacaaaggat gctttagata gagcagttgc
     4621 tgcttataac gctcttactg cacaacaaca aactcagcaa gaaaaagaga aagttgacaa
     4681 agctcaagct gcttataatg ctgctgtgat tgctgccaac aatgcatttg aatgggtggc
     4741 agataaggac aatgaaaatg ttgtgaaatt agtttctgat gcacaaggtc gctttgaaat
     4801 tacaggcctt cttgcaggta catattactt agaagaaaca aaacagcctg ctggttatgc
     4861 attactaact agtcgtcaga aatttgaagt cactgcaact tcttattcag cgactggaca
     4921 aggcattgag tatactgctg gttcaggtaa agatgacgct acaaaagtag tcaacaaaaa
     4981 aatcacgatc ccacaaacgg gtggtattgg tacaattatc tttgctgtag caggggctgt
     5041 gattatgggt attgcagtgt acgcatatgt taaaaacaac aaagatgagg atcaacttgc
     5101 ttaagtaaga gagaaaggag ccattgatga caatgcagaa aatgcagaaa atgcagaaaa
     5161 tgcagaaaat gattagtcgt atcttctttg ttatggctct gtgtttttct cttgtatggg
     5221 gtgcacatgc agtccaagcg caagaagatc acacgttggt cttgcaattg gagaactatc
     5281 aggaggtggt tagtcaattg ccatctcgtg atggtcatcg gttgcaggta tggaagttgg
     5341 atgattcgta ttcctatgat aatcgggtgc aaattgtgag agacttgcat tcgtgggatg
     5401 agaataaact ttcttctttc aaaaagactt cgtttgagat gaccttcctt gagaatcaga
     5461 ttgaagtatc tcatattcca aatggtcttt actatgttcg ctctattatc cagacggatg
     5521 cggtttctta tccagctgaa tttctttttg aaatgacaga tcagacggta gagcctttgg
     5581 tcattgtagc gaaaaaagca gatacggtga caacaaaggt gaagctgata aaggtggatc
     5641 aagaccacaa tcgcttggag ggtgtcggct ttaaattggt atcagtagca agagatggtt
     5701 ctgaaaaaga ggttcccttg attggagaat accgttacag ttcttctggt caagtaggga
     5761 gaactctcta tactgataaa aatggagaga ttgttgtgac aaatcttcct cttgggacct
     5821 atcgtttcaa ggaggtggag ccactggcag gctatactgt tacgacgatg gatacggatg
     5881 tccagttggt agatcatcag ctggtgacga ttacggttgt caatcagaaa ttaccacgtg
     5941 gcaatgttga ctttatgaag gtggatggta ggaccaatac ctctcttcaa ggggcaatgt
     6001 tcaaagtcat gaaagaagaa aacggacact atactcctgt tcttcaaaat ggtaaggaag
     6061 tagttgtggc atcagggaaa gatggtcgtt tccgagtgga aggtctagag tatgggacat
     6121 actatttatg ggagctccaa gctccaactg gttatgttca attaacatcg cctgtttcct
     6181 ttacaatcgg gaaagatact cgtaaggaac tggtaacagt ggttaaaaat aacaagcgac
     6241 cacggattga tgtgccagat acaggggaag aaaccttgta tatcttgatg cttgttgcca
     6301 ttttgttgtt tggtagtggc tattatctta cgaaaaaaac aaataactga tattcaatgt
     6361 acatcattat gaaaaagata gcaggctgaa gggaagacca gagtactctg aggtgatgtt
     6421 aatcaggaat catggtgatt tggcatgaat cataataacg gatatgaggc tgggcagatt
     6481 gtgccagcct cattgtgggt tattgtttgt aaaacgatag gactggtctg gtaatcattt
     6541 taggaatgga caggactggg attctgattt aaaatggatg gtgaatcaga aagaaatgag
     6601 attttctcgt ttctcttagc agataggatt gtctgttagg aaaagcgata aaatgatgag
     6661 tttgaagtta aaggaatgct gataaaaaat ggcaaaaaca aaaaagcaaa aacgaaacaa
     6721 tctcctatta ggagtggtat ttttcattgg aatagcggta atggcgtatc cgctggtgtc
     6781 tcgcttgtat tatcgagtgg aatcaaatca acaaattgct gactttgata aggaaaaagc
     6841 aacgttggat gaggctgaca ttgatgaacg aatgaaattg gcacaagcct tcaatgactc
     6901 tttgaataat gtagtgagtg gcgatccttg gtcggaagaa atgaagaaaa aagggcgagc
     6961 agagtatgca cgcatgttag aaatccatga gcggatgggg catgtggaaa tccctgctat
     7021 tgatgtagat ttgccggttt atgctggtac tgctgaagag gtattgcagc aaggcgctgg
     7081 acatctagag ggaacttctc taccgatcgg aggcaattcg acccatgcgg tgattacggc
     7141 acatacaggt ttgccaacgg ctaagatgtt tacggatttg accaaactta aagttgggga
     7201 taagttttat gtgcacaata tcaaggaagt gatggcctat caagtggatc aagtaaaggt
     7261 gattgagccg acgaactttg atgatttatt gattgtacca ggtcatgatt atgtgacctt
     7321 gctgacctgt acgccataca tgatcaatac ccatcgtcta ttggttcggg ggcatcggat
     7381 accgtacgta gcagaggttg aggaagaatt tattgcggca aacaaactca gtcatctcta
     7441 tcgctacctg ttttatgtgg cagttggttt gattgtgatt cttttatgga ttattcgacg
     7501 cttgcgcaag aagaaacggc aatcagaaag agctttgaaa gcattgaagg aagctactaa
     7561 ggaagtgaag gtagaggatg agtaagagta gatattcacg gaaaaagagc gtgaaaaaga
     7621 agaaaaatcc gttcattctt cttctgattt ttttggtggg gcttgccgtt gcgatgtatc
     7681 ccttggtgtc tcgttattat tatcgtattg agtcaaacga ggttattaaa gagtttgatg
     7741 agacggtttc ccagatggat aaggcggaac ttgaggagcg ttggcgcttg gctcaagcct
     7801 tcaatgcgac cttgaaacca tctgaaattc ttgatccttt tacagagcaa gagaaaaaga
     7861 aaggcgtctc agaatatgcc aatatgctaa aggtccatga gcggattggc tatgtggaaa
     7921 ttcctgcgat tgatcaggaa attccgatgt atgtcggaac gagtgaggaa attcttcaga
     7981 agggcgcagg attgctagag ggagcttcgt taccggttgg tggtgaaaat acccacacag
     8041 ttgtcactgc tcatagagga ttaccgacgg cagaactgtt tagtcaattg gataagatga
     8101 aaaaagggga tatcttttat cttcacgttt tagatcaggt gttggcctac caagtggatc
     8161 agatagtgac ggtggagccg aatgactttg agcctgtctt gattcaacat ggggaagatt
     8221 atgcgacctt gttgacttgt acaccgtata tgattaacag tcatcgtctg ttggtacgtg
     8281 ggaagcggat tccgtatacg gcaccaattg cagagcggaa tcgagcggtg agagagcgtg
     8341 ggcaattctg gttgtggtta ttactaggag cgatggcggt catccttctc ttgctgtatc
     8401 gcgtgtatcg taatcgacgg attgtcaaag gactagaaaa gcaattggag gggcgtcatg
     8461 tcaaggacta aactacgagc cttattggga tacttgttga tgttggtagc ctgtttgatt
     8521 cctatttatt gttttggaca gatggtgttg cagtctcttg gacaggtgaa aggtcatgct
     8581 acatttgtga aatccatgac aactgaaatg taccaagaac aacagaacca ttctctcgcc
     8641 tacaatcaac gcttggcttc gcaaaatcgc attgtagatc cttttttggc ggagggatat
     8701 gaggtcaatt accaagtgtc tgacgaccct gatgcagtct atggttactt gtctattcca
     8761 agtttggaaa tcatggagcc ggtttatttg ggagcagatt atcatcattt agggatgggc
     8821 ttggctcatg tggatggtac accgctgcct ctggatggta cagggattcg ctcagtgatt
     8881 gctgggcacc gtgcagagcc aagccatgtc tttttccgcc atttggatca gctaaaagtt
     8941 ggagatgctc tttattatga taatggccag gaaattgtag aatatcagat gatggacaca
     9001 gagattattt taccgtcgga atgggaaaaa ttagaatcgg ttagctctaa aaatatcatg
     9061 accttgataa cctgcgatcc gattcctacc tttaataaac gcttattagt gaattttgaa
     9121 cgagtcgctg tttatcaaaa atcagatcca caaacagctg cagttgcgag ggttgctttt
     9181 acgaaagaag gacaatctgt atcgcgtgtt gcaacctctc aatggttgta ccgtgggcta
     9241 gtggtactgg catttctggg aatcctgttt gttttgtgga agctagcacg tttactacga
     9301 gggaaataaa aagaaatgaa aggaaagcta aggctgttcc tttttccggc tctttgtcaa
     9361 ctgtagtggg ttgaaaaaaa gctaagctcg agaaaggaca aattttgtcc tttctttttt
     9421 gatattcaga gcgataaaaa tccgtttttt gaagttttca aagtttcgaa aaccaaaggc
     9481 attgcgcttg ataagtttga tgagattatt ggtcgcttcc agtttggcat tagaatagtg
     9541 tagttgaagg gcgttgataa tcttttcttt atctttgagg aaggttttaa agacagtctg
     9601 aaaaatagga tgaacctgct taagattgtc ctcaataagt ccgaaaaatt tctctggttc
     9661 cttattctgg aagtgaaaaa gcaagagctg atagagttga tagtggtgtt tcaagtcttc
     9721 cgaatagctc aaaagcttgt ttaaaatctc tttattggtt aagtgcatac gaaaagtagg
     9781 acgataaaat cgcttatcac tcagtttacg gctatcctgt tgaatgagtt tccagtagcg
     9841 cttgatagcc ttgtattcat gggattttcg atgaaactga ttcatgattt gaacacgcac
     9901 acgactcata gcacggctaa gatgttgtac aatgtgaaag cgatcaagaa cgattttagc
     9961 acacgggaaa agttgtctag ctaagtcata gtaaggacta aacatatcca tagtaatgat
    10021 tttgacgcga catcggacgg ctctatcata tttaagaaag tgatctcgga tgacagcttg
    10081 tgttctacct tcaagaacag tgatgatatt gagattgtta aaatcttgcg caataaagct
    10141 catctccatc tcccgattga aacagtcact ccccggactg tttcaacgtc ccaggacata
    10201 atctcaggaa gacgcgaaaa atcatgctca aagtgagaat cattgagctt gcgaatgaca
    10261 gttgaagttg aaatggccag ctgatgagca atatcggtca tagaaatctt ctcaatcaac
    10321 ttttgcgcaa ttttttggtt gataatacga ggaatttgat gattcttctt gacgatagaa
    10381 gtttcagcga ccatcatttt tgaacagtga tagcacttga aacggcgttt tctaaggaga
    10441 attctagtag gcataccagt tgtttcgagg taagggatct tagacggttt ttgaaagtca
    10501 tatttcttca attggtttcc gcactcaggg caagatgggg cgtcgtagtc cagtttggcg
    10561 atgatttcct tgtgtgtatc cttattgatg atgtctaaaa tctggatatt agggtcttta
    10621 atgtctagta attttgtgat aaaatgtaat tgttccatat gattctttct aatgagttgt
    10681 tttgtcgctt ttcattatag gtcatatggg actttttttc tacacaaaaa taggctccat
    10741 aatatccata ggggatttac ccactacaaa tattatagag ccataaaagc atcaacatct
    10801 tgtgtggcac gtaaaccatg atattctaag acataaccat cgacacagat aattgttaaa
    10861 gtcagatttt cctgaattaa ttccttattt agggcttgga agaccggttt cattttatcc
    10921 atgtttgtat ttctccatca atttttgaac attggttaac ttagcaggtt tatttaatga
    10981 aatcacatat ttatgagttg gagtatgctc ttgaaaggca tacttcaagc taattttttg
    11041 aaaacgggtt agttctttgg agtctagcaa cttttctaca tcttggtttg ttaaataaga
    11101 atagtcttca aaaataactt ttcgcaaata gcgaaaccaa tggcttgcgt tgaattgtga
    11161 ttgtttggat gcctgtatca tataatcgta ccaatccatt gtcttcctcc tataaaattt
    11221 agtttatatt attgtagttt atattcgaaa atgtagtttt tcttaattag ctcgtatcta
    11281 taggatgata ctgaaaatct tcttgttgct ttaaatcaca atcgaaaaat tctgtttttc
    11341 atcttagaaa agaatgttta gaaatgtaaa atgaatcttt tttcttatcc gaaaacatta
    11401 ctaaagtata taatttagga agtcaattct gtatgataat gtttgtacta tcgtcgagtt
    11461 tttgcttgat tgcctaacga gataaatttt agaagaattt tcggtgtgat ttgacaagct
    11521 tctgactgga aggatagtta cactagtatt gtttattaaa atgagcagat agagaaaatt
    11581 tggaatctat ttgcttatta tcaatcgttt ttttagctta tttgtcttag attggtatag
    11641 aactgatcta tggattaatc ctcttgtatc ttatcctgtt cctaaatatg ttggtagaaa
    11701 aatgaagcag ttgttacgag tgtctgtatt gggaaaaatt ttgtctatac aattctttaa
    11761 atgatatgaa ggctaggaat gccaaaacac tgacatattt cgtttaaagc ctatccagcc
    11821 ttttcaattg tatttgtaga aatgctatca gtaatatatt cgcgaacact atgatttaca
    11881 acagtgtggt cgtacatctt tgtaacttta ttatacaaca accatttaca ggtgtaaagt
    11941 tgagcagtgt ctttagtaaa tttagggact tgttttgtca tagttttgat acctgtattc
    12001 gttgtttcat gagcatttga cgtttctttt catgtaggca tttcaacaat tagaatgata
    12061 tttttccgag gatgaactta tatattgtga ctttttagag ttatgatgcc tcttgatttg
    12121 actatcgcta tcaatttcat ccacttttac agtttcatgg ttttatgaac cgaaacatct
    12181 aggtacaggt tttagcatca attgattgtt tttgagccat atgaagttga aacgtggaga
    12241 tgcttttctt gtgataacgc cctattcaaa gaggcataac cgtttttgga gagagttcag
    12301 tactatgtgg cgctaaataa tatatgtaaa atagtatggt gtagagatat taaacaagat
    12361 ttaactaata cttttcgaaa atctcttcaa accacgtcag cgtcgcctta ccgtatagat
    12421 gttactgact tcgtcagttc tatctacaag ctcaaaacag tgttttgagc agcctgcagc
    12481 tagcttccta gtttgctctt tgattttcat tgagtatacg gagaattgta aaaacaaaaa
    12541 tggggatttc atataaagtt tattctagga gtatgtatct tgaataaaaa ttgttattta
    12601 agttctgggg gttatgatga atgtttttat aataataaaa tgcagctaga agaaaagtta
    12661 ttttaatata aatcactcaa catagcgaga aggcggtttc ctatatggaa gtcgtcttgt
    12721 tttcatattg tctaaatacg agatatctac tacaggttat agttgattta aacaggtgta
    12781 tagatttcta atatatatta aggtgaaata atatcttgta atacattgct atgctctatg
    12841 aaaaaagcaa cgatagctaa tgcacaagct cctatacttc cacgatgttt gttgtaaggt
    12901 aaaatttcaa tttctatatt acgagtaaag ggaacgaagt ggagctggtc ttggatttta
    12961 tccctgactt catgagtgaa aggttgataa ttaagcaatt gactgttgat atagatttta
    13021 tcagcaggat tgatgaggag aagatttgca atagaagtgg ccaataaatt gactccttta
    13081 tcaatttgtt ggcgtaaagc ggagtcgcct aaattataag ccgttaaaag ggtgtctaaa
    13141 tgaatgtctt tttcagtctt tacaaggctt tttagtacag ttagttggga atttttaaat
    13201 aataattggg cgtgtttgat taaccaagca tccgaaatat atgtttgtaa acaacctttt
    13261 tttccgcatt cacaatattg cccattcaat tcgacaatgg tgtgtccaat ttctccgata
    13321 taaggatttt tagaggctcc tattttttct tttgtgaaaa aggaagtgta aatacctaat
    13381 ccagcgtgta ggaaaataaa gttatcgggg gtattgtgtg gattaaaaag gtattgtcct
    13441 atagccatac aatcgatatt attttttaca ataaaaggaa aattgaatct tttaattaca
    13501 tttaataaat taaaagattc ccatatgggg ttgtttgtaa tgatacttcc ggagtctttg
    13561 ttataatgtc caggtattga taagccaaat ccaagtaatt ttgtttccaa agggacgtac
    13621 tctatagctg tttttatcat attggtaatg gtggaattga tttctgaaat aggataatct
    13681 tcattcaaaa tttctgtctc gaaaagagtt ttcccttgta agtcacatag actgagaaag
    13741 atacctagga cgtttatttc aatacctcca acaacatacg gaatattatc tgtgatagaa
    13801 atagtttttc tacgtcttcc agatccggaa aactcgctaa attcatcacc agtttcgtat
    13861 atgagggact gttcgcttag ctcttttatg atgttagtcg ttgttgctgg agtaaggcct
    13921 gtttcattaa caatatctgt acgggatgtt gctggatttc gatatagaaa ctccagtata
    13981 gtggctctat tttgtaaaaa ggctgattgt tttgtaatca tttgtttcct cctttggttt
    14041 attttatatt aaacataaga aaaaatcaat taaaattatt attctataca aagaaaaaaa
    14101 tattgtaaaa acaacaaaaa atatattgac aacgctttct gttagtggta tatttaattt
    14161 ataaaaaata aaaaaaggag ttccggtgat gaacaatatt ttagcgtttt tagaaacaaa
    14221 agtcgctccg tttggtgaaa aagttggcaa ccaacggcat ttgaaagcta ttcgtgaagg
    14281 atttatgatg gcaatgcctt tgattttagt cggctcttta tttcttattc taatcagttg
    14341 gcctcaagag gattttacaa attggctgaa tagtgttgga ttgctaagta tcttgacaac
    14401 tatgaatcag tcaacagtag cgattatctc cttggtcgct tgtttcggta ttgcctacag
    14461 gttgtcggaa ggatatggta cagatggtcc gtcggcaggg atcatagcct tatccagttt
    14521 tgtattgatg gcacctcgtt tttcgagtat ggtttatgat aaaaatgggg agcaggtcaa
    14581 gcagttattt ggcggcgcaa taccattttc tagcctgaat gcatcttctt tgtttatggc
    14641 gattactatt ggattggtta cagcagagat ttatcgtatg tttatccagc gcggaattac
    14701 gataaaaatg ccaagtggtg tcccagatgt ggtaagtaaa tcattttcag ctcttttacc
    14761 tggctttact acttttgttt tgtgggctct ggtcttaaaa ggtcttgaag cggcaggagt
    14821 tgcaggaggt ctcaacggac tcctaggtgc aattgttgga acaccgctta agttaattgc
    14881 aggaacgctt ccaggtatga ttctatgtgt tattgtaaac tcattctttt ggttctgtgg
    14941 agttaatggg ggacaagttt taaatgcttt tgtagatcca gtttggttac aatttactac
    15001 agaaaaccaa gaagctgtgg ctgcaggaca aacactccaa cacattatta cattaccgtt
    15061 taaagattta tttgtattta ttggtggcgg tggagcgact attggtcttg cgatttgtct
    15121 cttcctattt agtaagagtc gtgcgaataa aacattaggt aagctagcta ttataccgtc
    15181 tatttttaat atcaatacag ctattctatt tacgtttcca acagttttaa atccgattat
    15241 gctgattccg tttattgcta ctcctacaat caatgcctta attacctatg tatcaatggt
    15301 tgtaggatta gtaccctata caacaggtgt aatccttccg tggacaatgc caccgatcat
    15361 aggaggcttc cttgcgacag gagctagttg gcgaggagct ctattacaag ttgttttgat
    15421 tttggtttct gtagcaattt attatccatt cttcaaaatt gcagataaac gcaatcttga
    15481 aaaagaaaaa gctactgttg gagggaaata agatggttat cagagtattt gataagcaga
    15541 aaaatactta ttctagcttt gccttagagg aattaagtta ctatataaat cgggtcttta
    15601 agactgacat agaacttgtc gaggagaagg aagcggatat ttttgtagga ttagtcaata
    15661 aagaggatag aagagaccat gttcttatct cattagacaa gggtaagggg agaattgagt
    15721 ctaatacaat tgtaggttta cttattggaa tttaccgaat gtttcatgaa tttggggttg
    15781 tgtatactag accagggcgc ggacatgact ttgttccaga gttacgattt gaagattttt
    15841 tagataaaca gctatctata gatgaaacag ccagttacta tcatagggga gtatgtatag
    15901 agggagcgga ttcatttgaa aatatactag atttcattga ttggctacct aagattggga
    15961 tgaacagttt tttcatccag tttgaaaatc cctactcttt tttgaaacgt tggtatgaac
    16021 atgaatttaa tccatatcta aataaagaac aattttcaaa tgaattagta caagaattga
    16081 gtgataggtt ggataaagaa ttgcaaaaaa gaggtcttat tcatcatcgt gttggtcatg
    16141 gatggacagg tgaagtttta ggttactctt caaaatttgg ctgggaatca ggtcttagta
    16201 tttcagagga gaagaaaccc tatgtcgctg aaataagcgg gaaacgagaa ttatttaata
    16261 cggctccgat tttaaccagt ctggattttt caaatccaga tgtggcggat aagatggtag
    16321 aaattatcaa ggattatgcc aagaaaagac ctgatgttaa ctacttacat gtatggttgt
    16381 cggatgctcg taataatatt tgtgaatgcg aaaactgtag acaagaattg gtttcggatc
    16441 agtatattcg tattctcaat caattggata gggctttaac gagtgaggga ttagatacaa
    16501 agatttgttt tctgctttac catgagttgc tatgggcgcc tcagaaagaa aaattagata
    16561 atcctgaacg ctttaccatg atgtttgcac cgattacaag aacatttgaa atgagttatg
    16621 cagatgtaga ttttgacaat tccataccta cgcctaaacc ttatctgcgt aataaaatta
    16681 tacttccgaa ttctcttgag gaaaatttat cttatctttt tgagtggcaa aaaacattta
    16741 aaggagatag tttcgtatat gactatcctt tagggcgtgc tcattatggc gatttaggct
    16801 atatgaaaat tagtcaaacc atttacagag atgtatctta tctttctaac ctacatttga
    16861 acggttacat ttcgtgtcaa gaattacgtg ccggattccc tcataatttt cctaattatg
    16921 ttatggggga aatgctctgg aagaagacaa gaagttatga agaattgatt gaagaatact
    16981 tttctgcttt gtatggggaa aattggcagt ctgttgttga atatttagaa aaattatcca
    17041 tttattcctc ttgtgattat tttaatgcaa ttggcagccg tcaaagtgat gttttagcga
    17101 atcattatta tatagcttac aatctagctg ataatttttt accaattatt gaggaaaata
    17161 tttctaagtt attaaatagt caaaaggatg aatggaaaca gctcagttat catcgtgaat
    17221 atgttgttaa gatggcgaag gctttatatc ttcaagcaac tggaaaaaca aggcaagctc
    17281 aagatgaatg gagaaatgtg ttgaattata tccgtgggca cgaattgcta tttcaatcta
    17341 atttggatgt ttatcgtgta attgaagtag caaaaaatta cgctggtttc cacttataaa
    17401 tcataagtat agaaaatgaa ctaaggtatt cagagaagat tgaccctaaa tattatgaaa
    17461 tttaaggatt tttaagatat ttagggtcga ctttctattt gtatcgtagc gaagtcattt
    17521 taataatgat gtgtaaaaga tggatcaaga ttgaggagga agaaagatga aatcaaaaga
    17581 agaaataaat atgcttggtt ttacaattgt cgcttacgca ggagatgcaa ggtcagattt
    17641 gatggatgct ttggcgtttg cgagagatgg atattttgaa caggcaagag aattggttga
    17701 gtctgcaaac gactcaatag tgtctgccca tcgagaacag actaatttat tagcagagga
    17761 ggcatatgga gataattttg aagtgagctt tattatgatt catggtcaag atactttgat
    17821 gacaacgatg ctattgtatg atcaggtcaa gttttttatt gatgaatatg aacgaattcg
    17881 aaagattgaa gaacatattg gtttgcaatg aggattagtc atggaaaatt tacaggttaa
    17941 agccttaccg aaggagtttt tattaggagc tgctaccgct gcttatcaag tagagggtgc
    18001 aactagggta gatggcaaag gaacaaatat gtgggatgtt tatttgcaag aaaacagtcc
    18061 gttcttacca gatccagcta gtgattttta ttatcgttac gaagaggata tagctttggc
    18121 ggcagaacat ggtttgcagg ctttgcgttt atctatttct tgggttcgta tatttcctga
    18181 tatagatggg gagcctaata tattagctgt tcgttattac catagagtct ttcagtcttg
    18241 cttaaaacat aatgtgattc cgtttgtttc tttacatcat tttgattcgc ctcagaaaat
    18301 gttagaaaca ggggattggt tgaatagaga gaatattgat cgtttcatac gatatgctcg
    18361 cttttgtttc caagaattta cagaagtcaa gcattggttt acaatcaatg aactgatgtc
    18421 tcttgctgca ggtcaatata taggaggtca gtttcctcca aatcatcatt ttcaattatc
    18481 tgaagcaatt caagcgaatc ataatatgtt gttggcgcat gctcttgcag tcctcgaatt
    18541 tcatcaatta ggaattgagg gagagatagg ttgtattcat gctttaaagc caggctatcc
    18601 tattgatggg caaaaagaaa atattttagc agctaaacgg tatgatgttt ataataataa
    18661 atttctatta gatggaactt ttttgggcta ctacagtgat gacacgcttt ttcacttgaa
    18721 tcaaatattg gaagctaata attctagctt tattattgaa gatggtgatt tagaaattat
    18781 gaaaagagct gcacctctta atacgatgtt tgggatgaat tattatcgtt cagaatttat
    18841 tcgtgaatac aaaggtgaaa atagacaaga atttaattca acaggaataa aaggacagtc
    18901 ttcttttaaa ttaaatgctc taggtgaatt tgtaaaaaag cctggtattc cgacaacaga
    18961 ttgggattgg aatatttatc ctcaagggtt atttgatatg ttgcttcgta tcaaagaaga
    19021 atatcctcaa catccggtca tttatttaac tgaaaatggt acagccctta aagaggttaa
    19081 gccagagggc gagaatgata ttattgatga cagtaaaaga atccgttata ttgagcaaca
    19141 tttacacaaa gttttagagg ctcgagatag gggagtcaat attcaaggct attttatatg
    19201 gtctttgcaa gatcaatttt cttgggcgaa tggctacaat aagcgatatg gtcttttctt
    19261 tgttgattat gaaacacaga agagatatat taagaaaagt gctctttggg taaaaggatt
    19321 aaaacggaat taaggttagc gatttgactg atgtttaata tattttaact atgagcttaa
    19381 attttttaca ggaggagttt ttatggataa gttagtcgct gccattgaaa agcaacaagg
    19441 gaaatttgaa aaaatttcta ctaataatta tatgatggct attaaagatg gatttattgc
    19501 tactatgcct ttaattatgt tttcaagctt tttgatgatt attattatga ttcctaaaaa
    19561 tttcggagta gagttaccga gtccagctat tgcctggatg aggaaagtgt atatgctaac
    19621 catgggagtt ttgggtgtta ttgtttcagg gacagttgca aagtcattgg ctggaaatgt
    19681 taatagaaaa atgcctcctg gaaaggtaat aaatgatact tctgcaatgt tggcggccat
    19741 atgtggctat cttgtattaa ctgtaacgct tgtagttgat gagaaaacgg gatctacaag
    19801 tttgtcgaca aactatttag gatctcaagg attgataact tcgtttgtca gtgcctttat
    19861 tactgtaaat gtttaccgat tctgtattaa gcgagacatt actattcatt tacctaagga
    19921 agttcctggg gctatatcac aagcttttag agatattttt cctttttctt ttgttttact
    19981 tattagtggt ttgttagata ttgtatctcg gtttagttta gatgttcctt ttgcccaagt
    20041 atttcaacaa ctattgactc ctatttttaa gggggcagaa tcatatcctg ctatgatgtt
    20101 gatttggttt atgtgcgctt tgctttggtt tgttggaatt catggaccat ctattgtctt
    20161 acctgctgtt acagctttac aactgagcaa tatggaagag aatgctcaac ttcttgcaaa
    20221 tgggcagttt ccttatcatt ctttaacgcc taatttcgga aattatatcg ctgctatcgg
    20281 aggaacgggg gctacctttg ttgtaccatt tattttgatt ttctttatgc ggtctaaaca
    20341 attaaaatcg gtaggtaaag ctacaattac tcctgtttta tttgcggtga atgaacctct
    20401 tctatttggt atgccagtta ttttgaatcc ctatcttttt gtaccttttt tgatgactcc
    20461 accagtgaat gtatttctag gaaaggtctt tattgatttc tttggaatga atggatttta
    20521 tatccagtta ccttgggcct ttcctggtcc cttgggattg ttaattggaa cgaattttca
    20581 atctatctcc tttgtatttt tatctttgat tttagttgtt gacatattga tttatttgcc
    20641 attctgtaga gcgtatgata gacagttact gatgaaagaa tatgttgcaa gctcaaatga
    20701 tattatttta gaggaggaga caagtgaaat aatgcctggt gagatagatg taataaaaag
    20761 taaggagttg aaagtactgg ttctttgtgc agggtctgga acaagtgcgc aattagccaa
    20821 tgcaattaac gagggcgctc aattagcaga agttagagtg attgcgaatt caggagcgta
    20881 cggagctcat tatgatatta tgggtgttta tgatttaatt attctggccc cacaagttcg
    20941 gagttattat agagagatga aggtggatgc agaaagatta ggtattcaga tagttgctac
    21001 cagaggaatg gaatatattc atttaacaaa gaatccaagt aaatccttac aatttgtatt
    21061 ggagcattac caagctgtgt agtaagtttt tccatctttt atttgagtaa ggactttgct
    21121 tacagacagg cttggattta aaaacgttcc ccctttttta atataagaat ccctcttttt
    21181 acaattgtaa aaagagggat tttgtatttt atctcttaga ccaagttctc ttcataaaga
    21241 gaaggaggat tgggtaaatc tccaagcgcc ctgcaatcat tgcaaaggat aggagaattt
    21301 ttgagatggg actaaagatt gagaaactag aagtggttcc tagaataggc ccgatattat
    21361 tgaaacagct aaagacagcg ctggtcacga ccagaaaatc attgctatct aggctgacaa
    21421 taaagataag cgctagcaaa atcatagcat agatgacaaa gtacttgaga atcttatgct
    21481 gggtatcttt gtcaatcacc gttttattaa catggagggt caaaacacgg tggggcgata
    21541 ggattgacaa aatttggttt ttggcaattt ttgaaaggat gaggcctcga ataatcttga
    21601 gtccacctgc agttgatcca gcagagccac cgattgccat gaggaaaagg aggataaact
    21661 gggagaagag gggccagttg gtaatatctc catatccaaa accagttgtt gtaatgatgt
    21721 tggaaacctg gaagaaggtc atttcaaagc tctttgaaaa ccctgggtag aggtagaggg
    21781 tgttgaggct aatcaagcct gtagaaacca gtacaatgac caagtaagcc ctaagctctt
    21841 catctccaaa gaaggccttg atgcgacgga gcatgaggta gtagtagagg ttgaaattta
    21901 ctccaaaaac cagaactccg atactgacca gataggtaat cagtgagctg ccatagtggg
    21961 caattccgtc gttatagacg gtaaagcctc cagttcccgc tgtccccata gcaatgacaa
    22021 aactatcgta gagaggcata ccagctagat aatagatgat gacaaagagg gagaagagag
    22081 ctagataaag gagatagaga atctgggcag tgttttttag tttggataca accttgccaa
    22141 aaacaggacc tggaacctca gccttcatca cctctaggtg gctatttttg gcattgtcca
    22201 taatagcaag tgcaaaaaca agcactccca tccctccaat caagtgggta aaacttcgcc
    22261 agaagaggag ggaacgactg agaactgaaa cgtcgttcaa aatacttgct ccagtagtcg
    22321 taaagccgga actaatctca aaaaaggcat caataaggct ggggatttgc ccagaaaaga
    22381 caaaggggag accaccaaag aaagaccaaa ggatccaaca gagggcaacg atcaagactc
    22441 cctccttggc ataaatccgt tgattttttg gcttctgtaa actccctgaa ccgcctaaca
    22501 atacgagaat ccctatggtc gaaaagaggg ctgtaaagac ttggctcgat tcacggtaat
    22561 agacagcgat agccacagga accaagagga gaacagcttc aatcaaaagt aactttgaaa
    22621 ggaggtaacg aatcatactt ttattcattt cttacctcgc aatcaagtca taaatcttgg
    22681 tgatgtttgg caacaaggtt gttactagga gcttgtctcc aacttccaac atatcctccc
    22741 cagttgggaa aatagtcttg ccctttcgaa taatggctgc aataagaacc ccttttttca
    22801 atttcagttg agaaagaggt ttggcagtca ttttattggc ttccttgata tggaattgca
    22861 gggtttcgat ttggccattg gctagatggt gcatggcttg aaggtctgaa tactgggcat
    22921 taactcgacc acgaataaag tgcataatcg tatctacagc gatgctttta ggtgtgatga
    22981 tacttgaaaa atcaggcgca ttgataatct cgaggagact ggtacgattg accttagtaa
    23041 tatttttctg tacacctacc ctgtcaagga acatagatgt aatcagattt tcctcatcga
    23101 ctcctgttag agtcgcaacg gcatcatagt gttgagcact ttcttccagc aggatatctt
    23161 ttgcggttcc atctccttga acgatgtaga gatttgggaa tttctcgcta aagaagctgg
    23221 cgatttcagg attgatttca atgacttttg tatcgatacg actatctttg agaataccaa
    23281 gtagataata ggcaattcta cctgctccaa cgatgagaag gctcttcacg gcgcgtgatt
    23341 taaaataatt atggaagagt atcatatcga cacggttacc agtgacaaag attctatctt
    23401 tatcctgtac agtcatgtca ccgcttggaa tgataatttg atgatccctc tctatcgcac
    23461 agacaatgac attaccaaat tttttacgaa aatcagaaat gggcatttgg caaagaccgc
    23521 tggtggactt gacgacaaat tccatgaggc taacgcgtcc accagcaaag cgttcgacag
    23581 acagggcgtt ggggaagtca atgatattcg cgatagcgcg ggcagccaag agctcaggat
    23641 taacgataag agaaaaaccg agaatattct tttccttgaa ataagagtta gaatattcag
    23701 ggttccgcac ccgaacgata gtttctttag ctcccatttt cttggctaga actgctgcaa
    23761 tcatgttgac ttcatcgtgc tcagtcaggg cgataaagat atcacaatct tggacgctgg
    23821 cttgctcaag aatggcaaaa tcggccccgt taccaaggat accaatgata tcaaagcgac
    23881 tgacaatatg attgagaaca gcttcgtctt gctcaatcag caaaacatca tgcttttctg
    23941 caaccaagga gcgacagagg gcaaaaccaa cttttccccc tccgacaagg ataattttca
    24001 taataaaacc tactttttca tgatgtaact atcataccct ttttcaagaa aaaatgcacc
    24061 tactagctaa taacaagagc ttttagtgaa aattcgctat aaggtaaaac tataccctaa
    24121 ccaattgaaa tagctattag cgactttctc tgaaatatgg tatgataaag gatatacaag
    24181 gagataaaat gaataataat ttactggtat tacaatcaga ctttggtctg gttgatggtg
    24241 cggtatcggc tatgattgga gtggctttag aagagtctcc aaccttaaaa atccatcact
    24301 tgacgcacga tatcacgcct tataatattt ttgaggggag ctatcgtctc tttcagacgg
    24361 tggattactg gcctgaggga acgacgtttg tatcggttgt cgatccaggt gtcggttcga
    24421 aacgtaagag tgtagttgcc aagactgcaa aaaatcaata cattgtcacg ccagataatg
    24481 ggacgctttc ctttatcaag aaacacgttg gcattgtagc cattcgtgag atttctgagg
    24541 tggccaatag gcgtcaaaac acagagcatt cttatacctt ccacggtcgt gatgtctatg
    24601 cctatactgg tgctaaactg gccagtggtc acattacttt tgaggaagta gggccagagc
    24661 tcagtgtgga acagattgta gagcttccag tcgtagcgac catcatagaa gatcatctgg
    24721 tgaagggagc cattgatatt ctggatgtgc gtttcggttc gctttggacc tctatcacac
    24781 gggaagaatt ttacaagctg gaaccagaat ttggtgatcg ttttgaagtg accatctatc
    24841 atgctgatat gctggtctat caaaatcagg ttgtctatgg caaatcattt gcagatgtga
    24901 gaattgggca acccatcctt tacatcaact ctctctatcg tttaggtttg gctatcaacc
    24961 aaggttcctt tgccaaggcc tataatgtag gtgtcggttc atcttggacc attgaaataa
    25021 agaaaataga aggataaaat aggagaatag tatggaaatt aaatttacaa ttaaacaagt
    25081 tgttgctgtc ggaattggcg ctgccctctt tgtcgtcatc gggatgatca acattccaac
    25141 ccctgttcca aatacaagca tccagcttca gtatgcggta caagcgctac tttctattat
    25201 ttttggaccg attatcggtt tgcttgtcgg gttgattggt catgcaatca aggactctct
    25261 tgctggttat ggtctatggt ggacttggat tatcgctagc ggactctttg gtttagttgt
    25321 gggacttttt agaaagtacg ttcgcgtgat caatggtgtt tttgactgga aagatattct
    25381 tatttttaac ctcattcaac tacttgcaaa tgcccttgtt tggggtgtct tggcaccact
    25441 tggagatgtt gtgatttatc aagaagcggc agaaaaagta tttgcacaag ggattgttgc
    25501 gggaattgcc aatggtgtat ctgtagctat tgcaggaact cttctcttac ttgcctatgc
    25561 aggaacccaa actcgtgcag gaagtttgaa aaaggactaa tactcaatga aaatcaaaga
    25621 gcaaactagg aagttagccg caggttgctc aaaacagtgt tttgaaattg tggatagaac
    25681 tgacgaagtc agctcaaaac atggttttga ggttgtagat gaaactgacg aagtcagtaa
    25741 ccatacctac ggcaaggcga agctgacgtg gtttgaagag attttcgaag agtataaaat
    25801 gatggggaag gctgggcaac tagtcttttt cgatgtttat agattagtta ggcaagtaag
    25861 ctaggatagg aatctttttg gcgctaagat tttaagagaa gagactgcaa gaagggcttg
    25921 atttatgata aaatagaagt ctaagaagcg aatgaagaga gtaagatgaa agaagctata
    25981 attgagtgga aggatttctc tttccggtat gaaacacaac aagaaccgac cttgcaaggg
    26041 atagacttga ccatttacaa gggagagaaa gtcttaattg ttggaccatc tggatcaggt
    26101 aaatctacct tgggtcagtg tttgaatggg attattccca atatttacaa gggtcagaca
    26161 tatggagaat ttttgataaa gggtcaaaca gcctttgata tgagcatcta tgataagtct
    26221 catctggtta gcacagtttt gcaggataca gatgggcagt ttattggctt gtctgtggca
    26281 gaagatttgg cgtttgctct ggaaaatgat gtgacagccc tagatgagat gaaaggtcgt
    26341 gtttataaat gggctgaaaa gctggacctt cttcctttac tggatcagcg tcctcaggat
    26401 ttgtcaggtg gacaaaagca gcgagtcagt ctggctggtg tcttgattga tgaaagtccg
    26461 attctcttgt ttgatgagcc actcgccaat ctagatccca agtcaggtca ggatattatc
    26521 gaattgattg accagattca taaggaagag gggacgacga ctctgattat cgagcaccgt
    26581 ttggaggacg ttctgcatcg ccctgtggat cggattgtct tgataaacga tggtcgtatc
    26641 ctttttaatg ggagccctga ccagttgctt gcgactgatt tattgactca aaatggaatt
    26701 cgagaacccc tttatctaac gactctccgt caattaggtg tggacttagt caaggaagaa
    26761 caattagcag atctggataa cttgtctatc tcaaaagggc aaatccagtt acagacggaa
    26821 ctggtaaaag aaaccccagc attgcagtca ctctttatac tagaggaagt atctttttct
    26881 tataatgata gaccgatttt aaaatcccta catttagata ttaaaaaggg tgaaaagatt
    26941 gctattgtcg gaaaaaatgg agcagggaaa tcaactctag ccaaggctat aagtagcttt
    27001 attcagacgg aaggacgcta tctttgggaa aaacaggata taaaaggcga ttctgttgca
    27061 gagcgggcgg aacgagtagg ctatgtgcta caaaatccta atcaaatgat ttcaaccaat
    27121 atgatttttg atgaggtggc tctagggctc cgtttgcgag gtgtgaatga gaaggaaatt
    27181 gaaacgagag tctatgaaac cttgaaaatc tgtggacttt atgaattccg taattggcct
    27241 atttctgccc tgtcatttgg tcagaaaaaa cgtgtcacca ttgcttcaat tttggtctta
    27301 ggcgctgaaa ttatcctcct agatgaaccg actgcgggtc aagaccagaa gaactatact
    27361 gagattatgg aatttctcga agaactgcat caacaagggc ataccattgt catgattacc
    27421 catgatatgc aattgatgct ggattattca gatcgagccc ttgtcatggt ggatggagaa
    27481 ttgattgccg atactgttcc agccagtctg ttgagcgatc ctgagctgtt agtaaaagcc
    27541 aatctaaaag aaacctccat ctttaacttg gctaagaaac tagatgtgga tccattggat
    27601 ttaacggcat tttacaaaga gaggagagag ggatgcaagc taaattaatc ggttaccagc
    27661 atagagatac tgtgattcat cgcttgtcag gagctgggaa acttctcttt ttcattctgg
    27721 tatcattggc gaccatgatt agctatgata ccagaatgct cttgctgatt gccatctttt
    27781 cagtctttct cctctattta tcagaaattc gctttaaaga tgtttccttt gtagccgttt
    27841 ttgcgacggt atttgccgtt ttaaacgttt tgatggtcta tctcttttct cccgagtatg
    27901 gggttggact ttatggagag agaagtgtga tttggcaggg aatcggtgtc tacactctaa
    27961 ccagccagga gctcttttat ctgctaaatt tggccattaa gtatctttgc accattcctc
    28021 tggctattat ctttttgatg acaacccatc ctagtcagtt tgcttccagt ttaaatcaaa
    28081 ttggtgtgcc ctataagatt gcttattctg tcagcctgac cttgcgctat attccagatt
    28141 tgcaggaaga attctttact atcaagatgt ctcaggaggc gcgtgggatg gaattatcca
    28201 agaaagcttc tcttatgcaa cgaatcaaag gcaatctgct cattattacg cccttgattt
    28261 ttagctcgct agaacgcatt gataccattg cgactgccat ggagcttcgc cgctttggga
    28321 aagagaaaaa acgcacatgg tatagttatc agaccttgaa aaaaggagac tatattacct
    28381 tgctcttggc aaccttgttt ttagtagcta gtttactact tatcttgcag aatcagggac
    28441 gattttacaa cccttggaaa tagcttgaaa aaattgaaaa aatcaagtcg tttctattga
    28501 caatgattct gaaagtgtta tactaagaaa gtagtttcgc tgatttactt caaacctgtt
    28561 gtgaggtaag ttaacgatgc cttaaccacg ctgtctgctg agcttgactc cgggcagtgt
    28621 ggctattttt ttgcaatggt gaaaggaagc aagtcatgac aaatcacatt gtattatttg
    28681 aacctcaaat tccacaaaat acgggcaata tcgcgcgtac ttgcgctgcg accaattctc
    28741 ccctccacat catcaagcct atgggctttc ctattgatga ccgcaagatg aagcgggctg
    28801 gattggatta ctgggataag ctagagattt atttttacga gagtttggaa gatttcatat
    28861 ctcagatgaa gggaaaactc tatctgattt cgaaattcgc ggaaaaagtc tattctgagg
    28921 tggatttatc gactgacgag gaccattatt ttctttttgg acgtgaagac aagggcttac
    28981 ctgaagattt tatgcgagaa catcctgaga aggctctccg tattcccatg aatgatgaac
    29041 atgtccgcag tctcaatgtg tctaataccg tctgcatgat tgtctatgag gctcttcgcc
    29101 agcagaactt tgcaggtctt gagctcgtcc atacctatga agtggataaa ttgaaataaa
    29161 aaatgaaaat gaacaaaatg cttgcgcttg caagcgtttt ttgttatgat aaaagagtct
    29221 tcagggcagg gtgtgattcc cgaccggcgg tgactttaac taggaaatga tcttttcctt
    29281 ttatactttg ttgacaagct ttgcctaacc agaagttatg cctacagctt gtcgcctagt
    29341 ctaaaagaaa aatctctatt tccttctctt taaagaagtc cgcgagcgca agctgatgtg
    29401 gtgagattcc acaaccgaca gtatagtctg gatgggagaa gacgaaagaa tagctttgtc
    29461 tgttttgata gatttatagc cggattgtaa ccacttgctt tgtttttctt taatagagta
    29521 agagggaact tttgggatat aaaaagtgag aatagataga ggaatccttt ccaacttctt
    29581 ctgattttat agaaaattgg aggaacctgt tatgacaaac acacgtcgac tttcgaccat
    29641 tgcaattcta tcagccatct catttgtgct gatgtacttt gactttccgc ttttaccagc
    29701 ggcatctttc ctcaagatcg aatttagtat cttgccagtc cttgtgggtc tggtggtcat
    29761 ggatttgcct gctgctctag gagtgctctt gcttcgctca ctcttgaaat tgcttcttaa
    29821 cagccaagga gtgaatactt acattggttt gccgatgaat atcgtagctt tgggagtttt
    29881 tgtcatcgta tttgctttga tttggaaaaa ggaacggaca acccttcgtt tcctactagg
    29941 ctctctagct ggaactattg gtttaacctt ggccatgttg gttctcaact atgtttatgc
    30001 tgttcctttg tacgctaagt ttgctaactt tgatattgga aaaattttgg gattttccaa
    30061 ctacctaatg accatggtat taccttttaa cttgattgag ggtgtaatct tttccgtttc
    30121 attctggttg ttgtacgtcc ttttgaaacc aaccttaaaa cactatgaaa gataaacaaa
    30181 catttttaat gaagggcagt tttgcccttt tacttttcgt tattcttggc tatatggtca
    30241 aattttaccc tgaaatgttg gtcaattttg accaatcgat tcagactgcc attcgaggag
    30301 acttaccaga ttatttgact attctttttc gagccctcac acgtctgatt gatatcccag
    30361 tgattatcac ttgggttgtc attacagctt ttgtctttta tcgtaagcga tggaagatag
    30421 aaagtttctt catgctggga aatctggctt tggcaggtct tttaatcgtg acctttaaaa
    30481 atatctacca gcgcccacga ccagctatct tacatctggt ggaagagaag ggattttcct
    30541 tcccaagtgg gcattctcta gctgtaacgc tgatggtagg gactttgatt gttattctta
    30601 gtcagcggat taaagatcag gtctggagaa aaatcgtaca aatcgtcctt ggcctctacc
    30661 tagtcagtgt gctggtatca agagtctatc tgggagttca ttacccatca gacgtccttg
    30721 ccagtctctg tgtgggcttg ggagtcctgt ttatcgagtt tcccttttat gacaagctcc
    30781 gcttccaatg gcgatttaaa ggcaaacaga agtgagtatc gaattccctt gagagaaaga
    30841 aatgaaagtc aatatagcag atcttcatcc gactcaacta tatttatcag aaaagaagtt
    30901 gcaagatatt cagatgcttt accagtcggc agaaacaatc caagtcgatc caatcagtat
    30961 tcttgccttt ggagattgtt tgctgattac agatgggcat cacagggctt atcaggcttt
    31021 attggcaggt cgggatacga tttctgctga gtgggataga gatggtggtg atgaactata
    31081 tcatttctat gcgcaagctt gcgaggaaag aaagatttac tctgtttttg atttagaaga
    31141 tcgtatccta gctcaagatg ggtatgaagc aaaatggtat aactggtgtg atggttttaa
    31201 tcaagcagca actcttttgt tgaaaaggta gtgcattgtg ttttgttcct tattataagg
    31261 tcaatcattg tgaggaagct tttgcttggt atcaggatgt gaacttggtt tacctcgtag
    31321 atggggtgaa gcttccttac agtcaagcga ccttggaagc catgtattcc tatttggatc
    31381 ggcatggtga gcttttttgg attgaagtca aggagaaggg agaatggttt ccaattgggg
    31441 atattacact atctcaggat aatctcccca ttgtgattgg gaattccgct taccaacatc
    31501 gaggacttgg aaaaagattc taagtgcttt gattgaattg gctcgagtaa aaggatggaa
    31561 agaattgaga gtcaaggaaa tctacaccta caatcatgct tctaggaggt gtttcaagtc
    31621 gcttggattt gtggaaaatg gagcaacaga aaaaggaagg ggttttatat tggaattagt
    31681 ctaatcctgc cactttctcc cccttaacct ttgactattc cgcaaaatta tcgtaaaata
    31741 aagagtaaat gataaaatga ggtcagagtc tgttcgctct gacgatagta gtataaatga
    31801 ggagaaacgc tttggaatta gaagtatttg ctgggcaaga aaaaagtgaa ctatctatga
    31861 ttgaggtagc gcgtgctatc ttagaacttc gtggtcgcga tcatgagatg cattttagcg
    31921 atcttgtaaa cgaaattcaa aactaccttg gaacatcaaa cagcgatatc cgcgaagctt
    31981 tgcctttgtt ctacacagag ttgaactttg acggtagctt catctcactt ggggacaaca
    32041 aatggggtct tcgttcatgg tatggtgtgg acgaaatcga cgaagaaatc atcgctcttg
    32101 aagaaaatga cgacgatgaa gtagcaccaa aagctaagaa aaaacgtgtc aatgccttta
    32161 tggatggtga ttcagatgcc attgactaca atgcagatga tccagaagac gaagatgcat
    32221 acgaagcaga tccagctctt tcatacgatg atgaaaatcc agatgatgaa aaaaatgaag
    32281 tggaagctta tgatgcagaa atcaacgaaa tcgctccaga tgacttggga gaagatgtgg
    32341 atctcaacga agacgacgac gagttttcag atgacgacgc tgaaaccagc gaggaataag
    32401 agttagctat tgacaattat cctattttta ggtatcatat tgtttgggca cctcttttag
    32461 aggtcggggc tccctagttc ttagggagct atttttgttt tttcaagaag ttatcttctt
    32521 gtattttata ctcaatgaaa atcaaagagc aagctaggaa actagccgta ggctgctcaa
    32581 aacactgttt tgaggttgta gataagactg acaaagtcag gaacacatat ctacggcaag
    32641 gcgacgttga cgcggtttga agagattttc gaagagtatt agttgtgaat ctggtgcagt
    32701 cgtcccagat tattcttatt agtagggtct tgttttctat atcccctcgt agttaacaag
    32761 accttgagca ttttagaaag aggaatctat gtctacgaaa tatatttttg taactggtgg
    32821 tgtggtatcg tctattggga aagggattgt ggcagcgagt ctaggccgtc tcttgaaaaa
    32881 tcgtggtctc aaagtaacca ttcaaaagtt tgacccttat atcaatattg atccgggaac
    32941 catgagtcct taccagcacg gggaagtttt tgtgacagat gacggagctg agacagattt
    33001 ggacttgggt cactatgaac gtttcatcga tatcaatctc aacaaatatt ccaacgtgac
    33061 aactgggaaa atttacagtg aagttcttcg taaagaacgc cgtggagaat accttggggc
    33121 aactgttcaa gtcattcctc atatcacaga tgctttgaaa gaaaaaatca agcgtgccgc
    33181 tctaacgacc gactctgatg tcattatcac agaggttggt ggaacagtag gagatatcga
    33241 gtccttgcca ttcctagagg ctcttcgtca gatgaaggca gatgtgggtg cggataatgt
    33301 catgtatatc catacaacct tgcttcctta cctcaaggct gctggtgaaa tgaaaaccaa
    33361 accaacccaa cactctgtca aagaattgcg tggcttggga atccaaccaa atatgttggt
    33421 tattcgtaca gaagagccag ctggtcaagg aattaaaaat aaactggccc agttctgtga
    33481 tgtggcacca gaagccgtta tcgaatcgtt ggatgttgaa cacctttacc aaattccact
    33541 gaacttgcag gcacaaggga tggaccaaat tgtttgtgat catttgaaat tagacgcacc
    33601 agcagcggat atgacagaat ggtcagccat ggtggacaag gtcatgaacc tcaagaaaca
    33661 agttaagatt tcccttgttg gtaagtatgt ggagttgcaa gatgcctata tctcagtggt
    33721 cgaagctttg aaacactctg gctatgtcaa tgatgcagaa gttaaaatca attgggtcaa
    33781 tgccaatgat gtgacagcag agaatgtagc agaactcttg tctgatgcag acgggatcat
    33841 cgtaccaggt ggttttggtc aacgtggtac agaagggaaa atccaagcca tccgctatgc
    33901 gcgtgaaaat gatgttccaa tgttgggagt ctgcttggga atgcagttga catgtatcga
    33961 gtttgctcgt cacgttttag gtcttgaagg tgccaattct gcagagcttg caccagaaac
    34021 aaaataccct atcattgata tcatgcgtga tcagattgat attgaggata tgggtggaac
    34081 ccttcgttta ggactttatc cgtctaagtt gaaacgtggc tctaaggctg ctgctgctta
    34141 tcacaatcaa gaagtggtgc aacgccgtca ccgtcaccgt tatgagttta ataatgcctt
    34201 ccgtgagcag tttgaggcag caggctttgt cttttcagga gtttctccag acaatcgttt
    34261 ggtagaaatc gtggaaattc ctgaaaataa attctttgta gcttgtcagt atcaccctga
    34321 actgtcaagc cgtccaaacc gaccagaaga actctacatt gcctttgtta ctgcagcggt
    34381 tgagaacagc aattagcaaa atcagaacct ttgagaaaaa tctcagaggt tttttgcaca
    34441 cgatgatatt gcagtatatc tgaggtagga gtcctctgta tgtacctgct accgttgaaa
    34501 tcaatagcga ctccctcttg ccctgtgcta gtgaatggat ttatcagtat attgaaatga
    34561 aataaaatct gaacaaatta attcggaaag ccaaatcaat ttctagcaaa gttttaggaa
    34621 ctggattgta tagtgaattg aaataagatg tgaacatctc tatcaggaaa gtcaaattaa
    34681 tttatataaa tattttagca gttaagatgg actgttatag attcaataca ctatactttt
    34741 ttaatttaat tcactatagt aaaatgaaat aataacagga caaatcgatc aggacagtca
    34801 aatctatttc taacaatgtt ttagaaatag aggtgtccta ttctagtttc aatatactat
    34861 atatctgcag aatactcttt cagtttcatt cagcctagtc ttgcttagga aaaagtaaaa
    34921 agccatccaa ttatgatgga tagcttcttg gttcttagat ttgttctgca aaaacctttt
    34981 cagcaaggtt catagcgtgg tctgatacac gagtgtagtg tgagatgatg tcgataaagt
    35041 tgaccccagc ttgtgttgaa cattcgcctt tgttgaggcg tttgatgtgg gtttttctga
    35101 gaacacgttc tatcttattg attgcttcat gacgttctac aagactgcgt gctttttcaa
    35161 tatcattgtt ttccacacta tccagagcat ctttgataaa gtcactagtt tggcggtaaa
    35221 cttcctctaa ttctttcaag gcggcatcag aaaattcaac atttttccgt tgaagatagt
    35281 cagtcagatt gagtagagcc tctgtgtggt ctccaatccg ttccaaatca cgggaggaat
    35341 caaggatatt ggtaagcact tcactttctt tttggctgag agcttcgctt gaaagggcaa
    35401 tgagataacg tgttaattgc tcatcgatgg tgttaattgc ttcttcggtt ttatgccctt
    35461 tttcagcaac tttttcatcc aagtcaatga tgtacttata ggaaaggtca aaggctttag
    35521 cagcgtagtt tcctaagtgc aagagctctt ttttagcatt tcctagagcg atagatgggg
    35581 cttgtttgat gaaatgttca tcaagatata agggttcgta tttgacaacc tcgtcctctc
    35641 caggaataat cttggttaca aagtaagcca gagctccgat aaatggaaat tggataatgg
    35701 tgttggtaat attaaaggtt ccgtgagcaa aggcgatggt catttccggt gctagattta
    35761 gcgtagtttc aaaccaatga atcaggacag taaaaggaac tagaaaaata acgcagacga
    35821 ctgttccgat aacgttgaag gcaacatgag ctcctgctac ccgtttagct gcaatattag
    35881 cccctaaaga ggcaatgatg gctgtaatgg ttgtcccgat attgtcacca aatagaactg
    35941 gcaaagctcc ctgtaggtca attagatcgc cggcgtagag gttttgtaaa atcccaatgg
    36001 tagccgaaga agcttgaatt agcaaggtca agccagtacc gacaaagaca cccaaaacag
    36061 gattcttact tagctcaatc atatagtcct taaagacctg taaatccttg agtggagcca
    36121 ttgcgccgct catgagattg agggcaaaaa agataccacc gacaccaaag aggatgcgtc
    36181 cgatattatt gactgtccga tttttcgtaa aaaagagaca gacggcaccg ataaagagca
    36241 taggtagggc atagttacct aatttaaaac cgatgagaaa ggatgtgaca gttgtcccaa
    36301 tattagcacc catgacaatc ccgatagcct gacgtaaggt taagagaccg gcactgacca
    36361 ggccgactgt aataactgtt acaccagaac tagactgaat tagagcagtc atcccaatac
    36421 caaccagaac tccaaagaaa ggattactag tatatttgtc aatgtaaaaa cgaaggcgat
    36481 ctccagcagc ttgttgcaaa ccgtctccca tggtcttgat actatataag aatagcccca
    36541 gaccacctaa aaagtgaaat aaaatttcct gccaattaat ggacatttct ttttcctccg
    36601 aaaaataatc gcggaatatc tcctattcta ttttaaagga taaaagtaaa tctaacaagt
    36661 gttaatgtca agtttgtaaa agaaaattat aattgataag tgtattattt ttaagagttt
    36721 ttaaccttat tttagatttg tgaaaacagc tattgttttt tgtctaaaaa tgttttagga
    36781 taaaaatgtg attatcatgg ttctagagtt aaaaaaccac agaatataaa gcgctttctt
    36841 aaaaacaaca aaatcaatct tttaggagga gaaaatgaag aatccatttt ttgaaagacg
    36901 ttgtcgttac agtattcgta agttatcagt aggagcctgc tcgctgatga ttggtgctgt
    36961 tttatttgct ggtccagcct tggctgaaga aactgcagtt cctgaaaata gcggagctaa
    37021 tacagagctt gtttcaggag agagtgagca ttcgaccaat gaagctgata agcagaatga
    37081 aggggaacat actagagaaa acaagctaga aaaggcagaa ggagtagcga cagcatctga
    37141 aactgcagaa gcagctagcg cagctaaacc agaggaaaaa gcaagtgagg cggttgcaga
    37201 aacaccatct gcagaagcaa aacctaagtc tgacaaggaa acagaagcaa agcccgaagc
    37261 aactaaccaa ggggatgagt ctaagccagc agcagaagct aataagactg aaaaagaagt
    37321 ccagccagat gtccctaaaa atacagaaaa aacattaaaa ccaaaggaaa tcaaatttaa
    37381 ttcttgggaa gaattgttaa aatgggaacc aggtgctcgt gaagatgatg ctattaaccg
    37441 cggatctgtt gtcctcgctt cacgtcggac aggtcattta gtcaatgaaa aagctagcaa
    37501 ggaagcaaaa gttcaagcct tatcaaacac taattctaaa gcaaaagacc atgcttctgt
    37561 tggtggagaa gagttcaagg cctatgcttt tgactattgg caatatctag attcaatggt
    37621 cttctgggaa ggtctcgtac caactcctga cgttattgat gcaggtcacc gtaacggggt
    37681 tcctgtatac ggtacactct tcttcaactg gtctaatagt attgcagatc aagaaagatt
    37741 tgctgaagct ttgaagcaag acgcagatgg tagcttccca attgcccgta aattggtaga
    37801 catggccaag tattatggct atgatggcta tttcatcaac caagaaacaa ctggagattt
    37861 ggttaaacct cttggagaaa agatgcgcca gtttatgctc tatagcaagg aatatgctgc
    37921 taaggtaaac catccaatca agtattcttg gtatgatgcc atgacctata actatggacg
    37981 ttaccatcaa gatggtttgg gagaatacaa ctaccaattc atgcaaccag aaggagataa
    38041 ggttccggca gataacttct ttgctaactt taactgggat aaggctaaaa atgattacac
    38101 tattgcaact gccaactgga ttggtcgtaa tccttatgat gtatttgcag gtttggaatt
    38161 gcaacagggt ggttcctaca agacaaaggt taagtggaat gacattttag acgaaaatgg
    38221 gaaattgcgc ctttctcttg gtttatttgc cccagatacc attacaagtt taggaaaaac
    38281 tggtgaagat tatcataaaa atgaagatat cttctttaca ggttatcaag gagaccccac
    38341 tggccaaaaa ccaggtgaca aagattggta tggtattgct aacctagttg cggaccgtac
    38401 gccagcggta ggtaatactt ttactacttc ttttaataca ggtcatggta aaaaatggtt
    38461 cgtagatggt aaggtttcta aggattctga gtggaattat cgttcagtat caggtgttct
    38521 tccaacatgg cgctggtggc agacttcaac aggggaaaaa cttcgtgcag aatatgattt
    38581 tacagatgcc tataatggcg gaaattccct taaattctct ggtgatgtag ccggtaagac
    38641 agttcaggat gtgagacttt attctactaa gttagaagta actgagaaga ccaaacttcg
    38701 tgttgcccac aagggaggaa aaggttctaa agtttatatg gcattctcta caacttcaga
    38761 ctacaaattc gatgatgcag atgcatggaa agagctaacc ctttctgaca actggacaaa
    38821 tgaagaattt gatctcagct cactagcagg taaaaccatc tatgcagtta aactattttt
    38881 cgagcatgaa ggtgctgtaa aagattatca gttcaacctc ggacaattaa ctatctcgga
    38941 caatcaccaa gagccacaat cgccgacaag cttttctgta gtgaaacaat ctcttaaaaa
    39001 tgcccaagaa gcggaagcag ttgtgcaatt taaaggcaac aaggatgcag atttctatga
    39061 agtttatgaa aaagatggag acagctggaa attactaact ggctcatctt ctacaactat
    39121 ttatctacca aaagttagcc gctcagcaag tgctcagggt acaactcaag aactgaaggt
    39181 tgtagcagtc ggtaaaaatg gagttcgttc agaagctgca accacaacct ttgattgggg
    39241 tatgactgta aaagatacca gcctaccaaa accactagct gaaaatatcg ttccaggtgc
    39301 aacagttatt gatagtactt tccctaagac tgaaggtgga gaaggtattg aaggtatgtt
    39361 gaacggtacc attactagct tgtcagataa atggtcttca gctcagttga gtggtagtgt
    39421 ggatattcgt ttgaccaagc cacgtaccgt tgttagatgg gtcatggatc atgcaggggc
    39481 tggtggtgag tctgttaacg atggcttgat gaacaccaaa gactttgacc tttattataa
    39541 agatgcagat ggtgagtgga agctagctaa ggaagtccgt ggcaacaaag cacacgtgac
    39601 agatatcact cttgataaac caatcactgc tcaagactgg cgcttgaatg ttgtcacttc
    39661 tgacaatgga actccatgga aggctattcg tatctataac tggaaaatgt atgaaaagct
    39721 tgatactgag agtgtcaata ttccgatggc caaggctgca gcccgttctc taggtaataa
    39781 caaggtacaa gttggctttt cagatgtacc ggctggagca actattactg tttatgataa
    39841 tccaaattct caaactccgc ttgcaacctt gaagagcgaa gttggaggag acctagcaag
    39901 tgcaccattg gatttgacaa atcaatctgg tcttctttat tatcgtaccc agttgccagg
    39961 caaggaaatt agtaatgtcc tagcagtttc cgttccaaaa gatgacagaa gaatcaagtc
    40021 agtcagccta gaaacaggac ctaagaaaac aagctacgcc gaaggggagg atttggacct
    40081 tagaggtggt gttcttcgag ttcagtatga aggaggaact gaggacgaac tcattcgcct
    40141 aactcacgca ggtgtatcag tatcaggttt tgatacgcat cataagggag aacagaatct
    40201 tactctccaa tatttgggac aaccggtaaa tgctaatttg tcagtgactg tcactggcaa
    40261 agacgaagca agtccgaaaa ctattttggg aattgaagta agtcaggaac cgaaaaaaga
    40321 ttacctagtt ggtgatagct tagacttgtc tgaaggacgc tttgcagtgg cttatagcaa
    40381 tgacaccatg gaagaacatt cctttactga tgagggagtt gaaatttctg gttacgatgc
    40441 tcaaaagact ggtcgtcaaa ccttgacgct tcattaccaa ggccatgaag ttagctttga
    40501 tgttttggta tctccaaaag cagcattgaa cgatgagtac ctcaaacaaa aattagcaga
    40561 agttgaagct gctaagaaca aggtggtcta taactttgct tcaccagaag taaaagaagc
    40621 tttcttgaaa gcaattgaag cggccgaaca agtgttgaaa gaccatgaaa ctagcaccca
    40681 agatcaagtc aatgaccgac ttaataaatt gacagaggct cataaagctc tgaatggtca
    40741 agagaaattt aaggaagaaa agacagaact tgatcgctta acaggtgagg ttcaagaact
    40801 cttggctgcc aaaccaaacc atccttcagg ttctgcccta gctccgcttc ttgagaaaaa
    40861 caaggccttg gttgaaaaag tagatttgag tccagaagag cttacaacag cgaaacagag
    40921 tctaaaagat ctggttgctt tattgaaaga agacaagcca gcagtctttt ctgatagtaa
    40981 aacaggtgtt gaagtacact tctcaaataa agagaagact gtcatcaagg gtttgaaagt
    41041 agagcgtgtt caagcaagtg ctgaagagaa gaaatacttt gctggagaag atgctcatgt
    41101 ctttgaaata gaaggtttgg atgaaaaagg tcaagatgtt gatctctctt acgcttctat
    41161 tgtgaaaatc ccaattgaaa aagataagaa agttaagaaa gtatttttct tacctgaagg
    41221 caaagaggca gtagaattgg cttttgaaca aacggatagt catgttatct ttacagcacc
    41281 tcactttact cattatgcct ttgtttatga atctgctgaa aaaccacaac ctgctaaacc
    41341 agcaccacaa aacacagtcc ttccaaaacc tacttatcaa ccggcttctg atcaacaaaa
    41401 ggctcctaaa ttggaagttc aagaggaaaa ggttgccttt catcgtcaag agcatgaaaa
    41461 tgctgagatg ctagttgggg aacaacgagt catcatacag ggacgagatg gactgttaag
    41521 acatgtcttt gaagttgatg aaaacggtca gcgtcgtctt cgttcaacag aagtcatcca
    41581 agaagcgatt ccagaaattg ttgaaattgg aacaaaagta aaaacagtac cagcagtagt
    41641 agctacacag gaaaaaccag ctcaaaatac agcagttaaa tcagaagaag caagcaaaca
    41701 attgccaaat acaggaacag ctgatgctaa tgaagcccta atagcaggct tagccagcct
    41761 tggtcttgct agtttagcct tgaccttgag acggaaaaga gaagataaag attaaatatc
    41821 gaaaaatctt gtgaaatctt tccttatatt tccaaagtgt gatataatag tttcgaataa
    41881 aataaataaa ggagtttttg taacatggca aaacttactg ttaaagacgt tgacttgaaa
    41941 ggtaaaaaag tcctcgttcg tgttgacttc aacgtaccat tgaaagatgg cgtaatcact
    42001 aacgataacc gtatcacagc agctcttcca actattaagt acatcatcga acaaggtgga
    42061 cgtgcaattc ttttctctca ccttggacgt gtgaaagaag aagctgataa agctggtaaa
    42121 tcacttgctc ctgtagcagc tgacttggca gcaaaacttg gtcaagatgt tgttttccca
    42181 ggtgtcactc gtggtgctga attggaagcg gcaatcaacg ttcttgaaga tggacaagtt
    42241 ctcttggttg aaaacactcg ttacgaagat gttgacggca agaaagaatc taaaaacgat
    42301 cctgaacttg gtaaatactg ggcatcactt ggagatggta tcttcgtaaa cgatgcattc
    42361 ggtacagctc accgtgcaca cgcatctaac gttggtatct cagcaaacgt tgaaaaagca
    42421 gttgctggtt tccttcttga aaacgaaatt gcctatatcc aagaagcagt tgaaactcca
    42481 gaacgtccat tcgtggctat ccttggtggt tcaaaagttt cagacaagat cggtgttatc
    42541 gaaaacttgc ttgaaaaagc tgataaagtc cttatcggtg gtgggatgac ttacacattc
    42601 tacaaagcac aaggtatcga aatcggtaac tcacttgtag aagaagacaa attggatgtt
    42661 gcgaaagctc ttcttgaaaa agcaaatggt aaattgatct tgccagttga ctcaaaagaa
    42721 gctaacgcat ttgctggtta cactgaagtg cgtgacactg aaggtgaagc agtttctgaa
    42781 ggcttccttg gtcttgacat cggtccaaaa tctatcgcca aatttgacga agctttgact
    42841 ggtgccaaaa cagttgtatg gaacggacct atgggtgtat ttgaaaaccc agatttccaa
    42901 gctggtacaa tcggtgtgat ggacgctatc gtgaaacaac caggagttaa atcaatcatc
    42961 ggtggtggtg actcagctgc cgcagcgatt aaccttggcc gtgcagacaa gttctcatgg
    43021 attagtacgg gtggtggagc atcaatggaa cttcttgaag gtaaggttct tccaggactt
    43081 gcagccttga cagaaaaata agattttata aacaaatcaa agaagagagg gatgaaagtt
    43141 cctcttttct tttgcttaaa ataaaaacgc ttcctctcaa ctattactca taaaaatcac
    43201 cgatttatga taaaatggaa atagaaagtt gagattatga gttattttaa aaaatataaa
    43261 ttcgataaat cccagttcaa acttggtatg cgaaccttta aaacaggtat tgctgttttt
    43321 ctagttctct tgatttttgg cttttttggc tggaaaggtc ttcaaattgg tgctttgaca
    43381 gccgttttta gcctgaggga gagttttgat gagagtgttc attttgggac ttcgcgtatt
    43441 ctaggaaata gtatcggtgg actctatgcc ttggtcttct tcttattaaa tacctttttc
    43501 cacgaagcct tttgggtgac cttggtagtt gttccaatct gcaccatgtt aaccattatg
    43561 acaaatgtag ccatgaataa caaagcaggg gttattggtg gtgtagcagc tatgttaatc
    43621 attaccctat caattccaag tggtgagaca attttgtacg tgtttgtgcg tgtattagaa
    43681 acgtttatgg gagtttttgt cgcaattatc gtaaattacg atattgatcg tattcgtctc
    43741 tttttagaga aaaaagaaaa ataatgttac attttataac attatcaatt gacgtttgtc
    43801 tttttttaga ctataataga cagaaagaag gaaattgtaa atgaaggaaa aagaatttcg
    43861 ccgaaatatg gctgtttttc ctatcggcag tgttatgaag ttgaccgatc tatcggcgcg
    43921 tcagattcgt tattatgaag atcaagagtt gatcaagccc gatcgaaacg aaggaaatcg
    43981 tcgcatgtat tccttgaatg acatggatcg tctgcttgaa atcaaagatt atatctctga
    44041 aggttataat atcgctgcca ttaagaaaaa atatgctgaa cgtgaagcga aatccaagaa
    44101 agcggttagt cagactgaag tacgtcgtgc acttcacaat gaactcctcc aacaggggcg
    44161 ttttgcttca gtacagtcac cttttggtcg cggttaggca accgcaagta gtcatagatt
    44221 aaggagaaaa cttatgccaa tcacagctgc agatattcgt cgtgaagtca aggaaaaaaa
    44281 tgttaccttt attcgtctta tgttctcaga tattttggga accatgaaaa acgtcgaaat
    44341 tcctgctaca gatgaacagt tagataaggt cttgtcgaac aaggttatgt ttgatggatc
    44401 ttctattgaa ggttttgtac gtatcaatga gtcggatatg tacttgtacc cggacttgga
    44461 tacatggaca gtcttccctt ggggagatga aaatggaagt gttgcaggtc tgatctgtga
    44521 tgtttataca acagaaggtg aaccatttgc gggtgaccct cgtggtaatt tgaaacgagc
    44581 tcttcgtcac atggaagaag ttggattcaa atccttcaac cttggtccag agccagaatt
    44641 cttcctattt aagttggatg aaaatgggga cccaacactt gaagtgaatg acaagggtgg
    44701 ctactttgat ttggcaccta ctgaccttgc ggacaacaca cgtcgtgaga ttgtgaatgt
    44761 cttgaccaaa atgggatttg aagtagaagc gagtcaccac gaggttgcgg ttggacagca
    44821 tgagattgac tttaagtacg atgaagttct ccgtgcttgt gataagattc aaatctttaa
    44881 acttgttgtt aaaaccattg ctcgcaaaca cggactttac gcaacattta tggcgaagcc
    44941 aaaatttggt attgctggct caggtatgca ctgtaatatg tccttgtttg atgcagaagg
    45001 aaataacgcc ttctttgatc caaatgatcc aaaaggaatg cagttgtcag aaacagctta
    45061 ccatttccta ggcggtttga tcaagcatgc ttacaactat actgccatca tgaacccaac
    45121 agttaactca tacaaacgtt tggttccagg ttatgaagcg cctgtttaca ttgcttgggc
    45181 tggtcgtaac cgttcgccac ttgtgcgcgt acctgcttca cgtggtatgg gaactcgtct
    45241 tgagttgcgt tcagtggatc caatggcgaa cccttacatt gctatggctg ttcttttgga
    45301 agttggtttg tatggtattg aaaataaaat cgaagcacca gctcctatcg aagaaaatat
    45361 ctacatcatg acagcagaag agcgcaagga agctggtatt acagaccttc catcaactct
    45421 tcacaacgct ttgaaagctt tgacagaaga tgaagtggtt aaagctgctc tcggagatca
    45481 catctacact agcttccttg aagccaaacg aatcgaatgg gcaagttatg caaccttcgt
    45541 ttcacaatgg gaaattgata attatttaga cctttactaa tatagaagaa ag
//
LOCUS       DAVLHC010000014        44461 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.014, whole genome shotgun sequence.
ACCESSION   DAVLHC010000014 DAVLHC010000000
VERSION     DAVLHC010000014.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 44461)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 44461)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..44461
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.014"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            699..2714
                     /locus_tag="VXE25_000833"
     CDS             699..2714
                     /locus_tag="VXE25_000833"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="HEV0771324.1"
                     /translation="MKKLFILISNLLASLFFVWVFTIWTDTYVSYYYPNVVVHDSSPE
                     TTFQHVATRLEKLAEETDSFIAIQHQDPNSEGTTVFSYTTFGDGKLPDGLQEKNLEDA
                     QSSSVETNYFVFDGHLDIHLLREELSQLGLTNMHLTIPSKLSTLMAIFSNGFQLISLL
                     IFILTFVALTLISQISQLRSSGIRLISGEKRWSIFLRPVGEDLKGIAVGFSLAGVLAI
                     LMQKILSLPTQSLMTIGAGLLSYNLILLSISLFFAQLFAVGIKKIHLMQIIKGQVPVR
                     GIISLILIGQLLAIIIVTLGIGSSLKYSQAWQQHRIGQEVWSQERQLITLSISREGTS
                     PGFDEQAQRKLRTWYQLMDLAVSEQKAFLSRHQLIDRTLQNGMASSKNLTTSTEWHDY
                     SPNGNVLIVTPHYLERQNIPVDTTIKQKMNHLNVGEFVLLLPEHLRSEEEHYKSVFED
                     DLTSRMSSQDERQQMTATVGYLESGQDRFVYNTTPISYQQFLKDPIIIVITPQSTGPQ
                     SILFWIDAVQNYVLFNQLSDAQELIQRQGIENWVSEMQTGYHNYITLLDNIQRERWVM
                     LAGAVLGIATSILLFNTMNRLYFEEFRRAIFIKRIAGLRFLEIHRTYLFAQLGVFLLG
                     FVASVFLQVEIGVAFLVLLLFTGLSLLQLHVQMQKENKMSILVLKGG"
     gene            2716..3348
                     /locus_tag="VXE25_000834"
     CDS             2716..3348
                     /locus_tag="VXE25_000834"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0771325.1"
                     /translation="MIELKQVSKSFGERELFSNLSMTFEAGKVYALIGSSGSGKTTLM
                     NMIGKLEPYDGTIFYRGKDLANYKSSDFFRHELGYLFQNFGLIENQSIEENLKLGLIG
                     QKLSRSEQRLRQKQALEQVGLAYLDLDKRIFELSGGESQRVALAKIILKNPPFILADE
                     PTASIDPATSQLIMEILLSLRDDNRLIIIATHNPAIWEMADEVFTMDHLK"
     gene            complement(4259..4672)
                     /gene="ndk"
                     /locus_tag="VXE25_000835"
     CDS             complement(4259..4672)
                     /gene="ndk"
                     /locus_tag="VXE25_000835"
                     /EC_number="2.7.4.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000438285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside-diphosphate kinase"
                     /protein_id="HEV0771326.1"
                     /translation="MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEE
                     LIDQHYQDLVGQSFYLPIREFMTSGPVLVGVISGPKVIETWRTMMGATRPEESLPGTI
                     RGDFAKAAGENEVIQNVVHGSDSEESAKREIALWF"
     gene            complement(4783..8460)
                     /gene="rpoC"
                     /locus_tag="VXE25_000836"
     CDS             complement(4783..8460)
                     /gene="rpoC"
                     /locus_tag="VXE25_000836"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000228741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta'"
                     /protein_id="HEV0771327.1"
                     /translation="MVDVNRFKSMQITLASPSKVRSWSYGEVKKPETINYRTLKPERE
                     GLFDEVIFGPTKDWECACGKYKRIRYRGIVCDRCGVEVTRTKVRRERMGHIELKAPVS
                     HIWYFKGIPSRMGLTLDMSPRALEEVIYFAAYVVIDPKDTPLEHKSIMTEREYRERLR
                     EYGYGSFVAKMGAEAIQDLLKQVDLEKEIAELKEELKTATGQKRVKAIRRLDVLDAFY
                     KSGNKPEWMILNILPVIPPDLRPMLQLDGGRFASSDLNDLYRRVINRNNRLARLLELN
                     APGIIVQNEKRMLQEAVDALIDNGRRGRPITGPGSRPLKSLSHMLKGKQGRFRQNLLG
                     KRVDFSGRSVIAVGPTLKMYQCGVPREMAIELFKPFVMREIVARDIVQNVKAAKRLVE
                     RGDERIWDILEEVIKEHPVLLNRAPTLHRLGIQAFEPVLIDGKALRLHPLVCEAYNAD
                     FDGDQMAIHVPLSEEAQAEARILMLAAEHILNPKDGKPVVTPSQDMVLGNYYLTMEEA
                     GREGEGMVFKDRDEAVMAYRNGYIHLHSRVGIATDSLNKPWTEEQRHKVLLTTVGKIL
                     FNDIMPEGLLYLQEPNNANLTEGVPAKYFLPLGGDIKEAISNLELNPPFKKKNLGNII
                     AEIFKRFRTTETSALLDRMKNLGYHHSTLAGLTVGIADIPVVDDKTEIIEESHKRVEQ
                     ITKQFRRGMITDDERYNAVTAEWRAAREKLEKRLIANQDPKNPIVMMMDSGARGNISN
                     FSQLAGMRGLMAAPNGRIMELPILSNFREGLSVLEMFFSTHGARKGMTDTALKTADSG
                     YLTRRLVDVAQDVIIREDDCGTDRGLLIRSIAEGKEMIESLEERLNGRYTKKTVKHPE
                     TGAVIIGPNELITEDKAREIVNAGVEEVTIRSVFTCNTRHGVCRHCYGINLATGDAVE
                     VGEAVGTIAAQSIGEPGTQLTMRTFHTGGVASNTDITQGLPRVQEIFEARNPKGEAVI
                     TEVKGQVTAIEEDASTRTKKVFVKGETGEGEYVVPFTARMRVEVGGQVARGAALTEGS
                     IQPKRLLAVRDVLSVETYLLGEVQKVYRSQGVEIGDKHIEVMVRQMIRKVRVMDPGDT
                     DLLMGTLMDINDFTDANKDVLIAGGVPATGRPVLMGITKASLETNSFLSAASFQETTR
                     VLTDAAIRGKKDHLLGLKENVIIGKIIPAGTGMARYRNLEPHAVNEEEYLNPPVEEEG
                     NEETTEVVVDTAVETVEETVE"
     gene            complement(8493..12104)
                     /gene="rpoB"
                     /locus_tag="VXE25_000837"
     CDS             complement(8493..12104)
                     /gene="rpoB"
                     /locus_tag="VXE25_000837"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000907130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta"
                     /protein_id="HEV0771328.1"
                     /translation="MAGHDVQYGKHRTRRSFSRIKEVLDLPNLIEIQTDSFKAFLDHG
                     LKEVFEDVLPISNFTDTMELEFVGYEIKEPKYTLEEARIHDASYSAPIFVTFRLINKE
                     TGEIKTQEVFFGDFPIMTEMGTFIINGGERIIVSQLVRSPGVYFNDKVDKNGKVGYGS
                     TVIPNRGAWLELESDSKDITYTRIDRTRKIPFTTLVRALGFSGDDEIFDIFGDSELVR
                     NTVEKDIHKNPMDSRTDEALKEIYERLRPGEPKTAESSRSLLVARFFDPRRYDLAAVG
                     RYKINKKLNVKTRLLNQTIAEPLVDPETGEILVEAGTIMTRSVIESIESHLDGDLNKI
                     VYIPNDAAVVTEPVVLQKFKVIAPTDPDRVVTIIGNANPDDKVRTVTPADILAEMSYF
                     LNLAEGLGRVDDIDHLGNRRIRAVGELLANQVRLGLSRMERNVRERMSVQDNEVLTPQ
                     QIINIRPVTAAVKEFFGSSQLSQFMDQHNPLSELSHKRRLSALGPGGLTRDRAGYEVR
                     DVHYTHYGRMCPIETPEGPNIGLINNLSSYGHLNKYGFVQTPYRKVDRETGVVTNEIV
                     WLTADEEDEYTVAQANSRLNEDGTFAEKIVMGRHQGVNQEYPANIVDYMDVSPKQVVA
                     VATACIPFLENDDSNRALMGANMQRQAVPLINPQAPYVGTGMEYQAAHDSGAAVIAQY
                     DGKVTYADADKVEVRREDGSLDVYHIQKFRRSNSGTAYNQRTLVKVGDVVEKGDFIAD
                     GPSMENGEMALGQNPIVAYMTWEGYNFEDAVIMSERLVKDDVYTSVHLEEYESETRDT
                     KLGPEEITREIPNVGEDALKDLDEMGIIRIGAEVKEGDILVGKVTPKGEKDLSAEERL
                     LHAIFGDKSREVRDTSLRVPHGADGVVRDVKIFTRVNGDELQSGVNMLVRVYIAQKRK
                     IKVGDKMAGRHGNKGVVSRIVPVEDMPYLPDGTPVDIMLNPLGVPSRMNIGQVMELHL
                     GMAARTLGIHIATPVFDGASSEDLWSTVKEAGMDSDAKTILYDGRTGEPFDNRVSVGV
                     MYMIKLHHMVDDKLHARSVGPYSTVTQQPLGGKAQFGGQRFGEMEVWALEAYGASNVL
                     QEILTYKSDDINGRLKAYEAITKGKPIPKPGVPESFRVLVKELQSLGLDMRVLDEDDQ
                     EVELRDLDEGMDEDVIHVDDLEKAREKAAQEAKAAFEAEEAEKATKAEATEEAAEQE"
     gene            12520..12590
                     /locus_tag="VXE25_000838"
     tRNA            12520..12590
                     /locus_tag="VXE25_000838"
                     /product="tRNA-Cys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:12552..12554,aa:Cys,seq:gca)
     gene            complement(12788..14119)
                     /locus_tag="VXE25_000839"
     CDS             complement(12788..14119)
                     /locus_tag="VXE25_000839"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000390004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HlyC/CorC family transporter"
                     /protein_id="HEV0771329.1"
                     /translation="MEDPSSQNLLLQFVLLFILTVLNAFFSATEMAMVSLNRARVEQK
                     AEEGDRRYIRLLKVLENPNHFLSTIQVGITLITILSGASLTDTLGRVIASWLGNGETA
                     QAVATFLSLAFLTYISIVFGELYPKRIALNLKDALAIRTAPVIIGIGKLVSPFVWLLA
                     ASTNFLSHLTPMSFDDADEKMTRDEIAYMLTNSEETLDADEIEMLQGVFSLDELMARE
                     VMVPRTDAFMVDIQDDSQAIIQSILKQNYSRIPVYDGDKDNVIGIIHTKSLLKAGFVD
                     GFDNIVWKRILQDPLFVPETIFVDDLLKELRNTQRQMAILLDEYGGMAGLVTLEDLLE
                     EIVGEIDDETDKAAIDVHQIGEDTYIVQGTMTLNDFNNYFDVELESDDVDTIAGYYLT
                     GVGTIPTTEKLSYELVSQNKQFILTNDKVKNGRVTKVKVQITEVEIEEETE"
     gene            complement(14410..15234)
                     /gene="endA"
                     /locus_tag="VXE25_000840"
     CDS             complement(14410..15234)
                     /gene="endA"
                     /locus_tag="VXE25_000840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-entry nuclease EndA"
                     /protein_id="HEV0771330.1"
                     /translation="MNKKTRQTLIGLLVLLLLSTGSYYIKQMQSTANSPKTKLSQKKQ
                     ASEAPSQALAESVLTDAVKSQIKGSLEWNGSGAFIVNGNKTNLDAKVSSKPYADNKTK
                     TVGKETVPTVANALLSKATRQYKNRKETGNGSTSWTPPGWHQVKNLKGSYTHAVDRGH
                     LLGYALIGGLDGFDASTSNPKNIAVQTAWANQAQAEYSTGQNYYESKVRKALDQNKRV
                     RYRVTLYYASNEDLVPSASQIEAKSSDGELEFNVLVPNVQKGLQLDYRTGEVTVTQ"
     gene            complement(15273..15461)
                     /locus_tag="VXE25_000841"
     CDS             complement(15273..15461)
                     /locus_tag="VXE25_000841"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004245549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta"
                     /protein_id="HEV0771331.1"
                     /translation="MNKKSSYVVKRLLLVIIVLILGTLALGIGLMVGYGILGKGQDPW
                     AILSPAKWQELIHKFTGN"
     gene            complement(15454..16737)
                     /gene="murA"
                     /locus_tag="VXE25_000842"
     CDS             complement(15454..16737)
                     /gene="murA"
                     /locus_tag="VXE25_000842"
                     /EC_number="2.5.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase"
                     /protein_id="HEV0771332.1"
                     /translation="MDKIVVQGGDNRLVGSVTIEGAKNAVLPLLAATILASEGKTVLQ
                     NVPILSDVFIMNQVVGGLNAKVDFDEEAHLVKVDATGDITEEAPYKYVSKMRASIVVL
                     GPILARVGHAKVSMPGGCTIGSRPIDLHLKGLEAMGVKVSQTAGYIEAKAERLHGAHI
                     YMDFPSVGATQNLMMAATLADGVTVIENAAREPEIVDLAILLNEMGAKVKGAGTETIT
                     ITGVEKLHGTTHNVVQDRIEAGTFMVAAAMTGGDVLIRDAVWEHNRPLIAKLLEMGVE
                     VIEEDEGIRVRSQLENLKAVHVKTLPHPGFPTDMQAQFTALMTVAKGESTMVETVFEN
                     RFQHLEEMRRMGLHSEIIRDTARIVGGQPLQGAEVLSTDLRASAALILTGLVAQGETV
                     VGKLVHLDRGYYGFHEKLAQLGAKIQRIEASDEDE"
     gene            complement(16761..16991)
                     /locus_tag="VXE25_000843"
     CDS             complement(16761..16991)
                     /locus_tag="VXE25_000843"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014017351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1146 domain-containing protein"
                     /protein_id="HEV0771333.1"
                     /translation="MVQLLFTLSSHMLFIYVSFYLLKDLVRWEKVLKVTAENTRKVRL
                     LVAFFSIVIGYILSSFFISLYHLWQEALRGLL"
     gene            complement(17049..18086)
                     /locus_tag="VXE25_000844"
     CDS             complement(17049..18086)
                     /locus_tag="VXE25_000844"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PDZ domain-containing protein"
                     /protein_id="HEV0771334.1"
                     /translation="MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLK
                     VNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFTDIRSAQETTGGSSDVEFMRINQ
                     FYMQTSQNMAKYQGLKTAGKEIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
                     DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVIS
                     NVPISFSTAGIGGPSAGLMFSLAIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGID
                     KKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAKTIKTDMKIVPVKTL
                     QDAIDYLKNNP"
     gene            complement(18070..18558)
                     /gene="coaD"
                     /locus_tag="VXE25_000845"
     CDS             complement(18070..18558)
                     /gene="coaD"
                     /locus_tag="VXE25_000845"
                     /EC_number="2.7.7.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001280753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pantetheine-phosphate adenylyltransferase"
                     /protein_id="HEV0771335.1"
                     /translation="MSDKIGLFTGSFDPMTNGHLDIIERASRLFDKLYVGIFFNPHKQ
                     GFLPLENRKRGLEKALGHLENVEVVASHDKLVVDVAKRLGATFLVRGLRNAADLQYEA
                     SFDYYNHQLSSDIETIYLHSRPEHLYISSSGVRELLKFGQDIACHVPESILEEIRNEK
                     KD"
     gene            complement(18548..19087)
                     /gene="rsmD"
                     /locus_tag="VXE25_000846"
     CDS             complement(18548..19087)
                     /gene="rsmD"
                     /locus_tag="VXE25_000846"
                     /EC_number="2.1.1.171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006147838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (guanine(966)-N(2))-methyltransferase
                     RsmD"
                     /protein_id="HEV0771336.1"
                     /translation="MKIVSGIYGGRPLKTLEGKTTRPTSDKVRGAIFNMIGPYFEVGR
                     VLDLYAGSGGLSIEAVSRGMSSAVLVERDRKAQTIVAENIQMTKEVGKFQLLKMDAER
                     ALEQVSGEFDLVFLDPPYAKEQIVADIEKMAERELFSEDVMVVCETDKAVELPEEIAC
                     LGIWKEKIYGISKVTVYVR"
     gene            complement(19152..20144)
                     /locus_tag="VXE25_000847"
     CDS             complement(19152..20144)
                     /locus_tag="VXE25_000847"
                     /EC_number="6.3.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016502595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate--ammonia ligase"
                     /protein_id="HEV0771337.1"
                     /translation="MKKSFIHQQEEISFVKNTFTQYLKDKLEVVEVQGPILSKVGDGM
                     QDNLSGVENPVSVKVLQIPDATYEVVHSLAKWKRHTLARFGFGEGEGLFVHMKALRPD
                     EDSLDATHSVYVDQWDWEKVIPNGKRNIVYLKETVEKIYKAIRLTELAVEARYDIESI
                     LPKQITFIHTEELVERYPDLTPKERENAICKEFGAVFLIGIGGELPDGKPHDGRAPDY
                     DDWTSESENGYKGLNGDILVWNESLGGAFELSSMGIRVDEETLRRQVEITGDEDRLEL
                     EWHKSLLNGLFPLTIGGGIGQSRMAMFLLRKRHIGEVQTSVWPQEVRDTYENIL"
     gene            complement(20256..20939)
                     /locus_tag="VXE25_000848"
     CDS             complement(20256..20939)
                     /locus_tag="VXE25_000848"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015545711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Bax inhibitor-1/YccA family protein"
                     /protein_id="HEV0771338.1"
                     /translation="MNHTIIHDRAGLNQFYAKVYAFVGLGIGLSALVSGLMLTVFQSQ
                     LVYFLMQGRLWLTIATFAELALVFVASSMASRNSPAALPVFLLYSVLNGFTLSFVVAF
                     YTPGTVLSAFVSSALLFFVMAAVGIFTKKDLSGIGRAMMAALIGLLIAMVVNIFLASG
                     FFDYMISVAMVLVFSGLIAWDNQKIRLAYEQSQGRVATGWVVSMALSIYLDFINLFLS
                     ILRIFGRND"
     gene            complement(20995..21735)
                     /locus_tag="VXE25_000849"
     CDS             complement(20995..21735)
                     /locus_tag="VXE25_000849"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000152696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA methyltransferase"
                     /protein_id="HEV0771339.1"
                     /translation="MTIITSKANSVVKNAKKLHQKKYRKSAYLIEGWHLFEEAVQAGV
                     TIEKIFALENYRNQLAAFPQTVWISEDILLDLADSQTPQGIVAVVQKEEVGQADLSQG
                     KFLFLEDVQDPGNVGTIIRTADAAGFTGVIVSDKSADIYSLKTLRSMQGSHFHLPIYR
                     MTSQALLDETKKVAIPVLATTLSKDSVDYRELPSIENFVLVMGNEGQGISPLMAESAD
                     QLVHISMKGQAESLNVAVAAGILIFYLS"
     gene            21769..22047
                     /locus_tag="VXE25_000850"
     CDS             21769..22047
                     /locus_tag="VXE25_000850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001174612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acylphosphatase"
                     /protein_id="HEV0771340.1"
                     /translation="MQKVRMIAQGRVQGVGFRWGVYSLALEIGGITGRVWNNDDGTVE
                     ILAQADSSAIMAKFIQEIRKGPTPFSKVSYLDVKLSNFPPYYDFKIAN"
     gene            22125..23051
                     /gene="yidC"
                     /locus_tag="VXE25_000851"
     CDS             22125..23051
                     /gene="yidC"
                     /locus_tag="VXE25_000851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000835957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertase YidC"
                     /protein_id="HEV0771341.1"
                     /translation="MKSIKRFALSAMGVAMLLVLTGCVNVDKTTGQPTGFIWNTIGAP
                     MAEAIKYFATDKGLGFGVAIIIVTIIVRLIILPLGIYQSWKATLHSEKMNALKHVLEP
                     HQTRLKEATTQEEKLEAQQALFAAQKEHGISMFGGVGCFPILLQMPFFSAIYFAAQHT
                     EGVAQASYLGIPLGSPSMILVACAGVLYYLQSLLSLHGVEDEMQREQIKKMIYMSPLM
                     IVVFSLFSPASVTLYWVVGGFMMILQQFIVNYIVRPKLRKKVREELAKNPPKASAFSK
                     PSGRKDVTPEQPTAITSKKKHKNRNAGKQRSR"
     gene            complement(23233..24027)
                     /gene="pflA"
                     /locus_tag="VXE25_000852"
     CDS             complement(23233..24027)
                     /gene="pflA"
                     /locus_tag="VXE25_000852"
                     /EC_number="1.97.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001288284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate formate lyase-activating protein"
                     /protein_id="HEV0771342.1"
                     /translation="MSEETIDYGQVTGMVHSTESFGSVDGPGIRFIVFLQGCHMRCQY
                     CHNPDTWAMESNKSRERTVDDVLTEALRYRGFWGNKGGITVSGGEALLQIDFLIALFT
                     KAKEQGIHCTLDTCALPFRNKPRYLEKFDKLMAVTDLVLLDIKEINEEQHKIVTSQTN
                     KNILACAQYLSDIGKPVWIRHVLVPGLTDRDDDLIELGKFVKTLKNVDKFEILPYHTM
                     GEFKWRELGIPYSLEGVKPPTADRVKNAKKLMDTESYQDYMKRVHG"
     gene            complement(24153..25403)
                     /locus_tag="VXE25_000853"
     CDS             complement(24153..25403)
                     /locus_tag="VXE25_000853"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000856498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diaminopimelate decarboxylase"
                     /protein_id="HEV0771343.1"
                     /translation="MKTPFINREELEAIVAEFPTPFHLYDEKGIREKARAVNQAFSWN
                     KGFKEYFAVKATPTPAILKILQEEGCGVDCSSYVELLMSHKLDFLGSEIMFSSNNTPD
                     KEYAYARELGATINLDAFEDIEHLERVAGIPEIISCRYNPGGVFELGTDIMDNPGEAK
                     FGMTKDQLFEAFAILKEKGAKTFGLHSFLASNTVTHLYYPELARQLFELAVEIKEKLG
                     IWLDFINLSGGIGVNYRPDQEPNDIALIGEGVRKVYEEVLTPAGLGQVKIFTELGRFM
                     LAPHGALVTRVTHKKETYRTYLGVDASAVNLMRPAMYGAYHHISNVTHPDGPAEAVDV
                     VGSLCENNDKFAVNRELPHTEIGDLLVIHDTGAHGFSMGYQYNAKLRSAEILYTEEGK
                     ARQIRRAERPEDYFATLYGFDFEE"
     gene            complement(25470..26297)
                     /gene="purR"
                     /locus_tag="VXE25_000854"
     CDS             complement(25470..26297)
                     /gene="purR"
                     /locus_tag="VXE25_000854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004242125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pur operon repressor"
                     /protein_id="HEV0771344.1"
                     /translation="MKLRRSDRMVVISNYLINNPYKLTSLNTFAEKYESAKSSISEDI
                     VIIKRAFEEIEIGHIQTVTGAGGGVIFTPSISSQDAKEMVEDLRTKLSESDRILPGGY
                     IYLSDLLSTPAILKNIGRIIAKSFMDQKIDAVMTVATKGVPLANAVANVLNVSFVIVR
                     RDLKITEGSTVSVNYVSGSSGDRIEKMFLSKRSLKAGSRVLIVDDFLKGGGTVNGMIS
                     LLREFDSELAGVAVFADNAQEEREKQFDYKSLLKVTNIDVKNQAIDVEVGNIFDEDK"
     gene            complement(26564..27505)
                     /locus_tag="VXE25_000855"
     CDS             complement(26564..27505)
                     /locus_tag="VXE25_000855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3'-5' exoribonuclease YhaM family protein"
                     /protein_id="HEV0771345.1"
                     /translation="MKISHMKKDELFEGFYLIKSADLRQTRAGKNYLAFTFQDDSGEI
                     DGKLWDAQPHNIEAFTAGKVVHMKGRREVYNNTPQVNQITLRLPQAGEPNDPADFKVK
                     SPVDVKEIRDYMSQMIFKIENPVWQRIVRNLYTKYDKEFYSYPAAKTNHHAFETGLAY
                     HTATMVRLADAISEVYPQLNKSLLYAGIMLHDLAKVIELTGPDQTEYTVRGNLLGHIA
                     LIDSEITKTVMELGIDDTKEEVVLLRHVILSHHGLLEYGSPVRPRIMEAEIIHMIDNL
                     DASMMMMSTALALVDKGEMTNKIFAMDNRSFYKPDLD"
     gene            complement(27495..28751)
                     /locus_tag="VXE25_000856"
     CDS             complement(27495..28751)
                     /locus_tag="VXE25_000856"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000444769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA recombination protein RmuC"
                     /protein_id="HEV0771346.1"
                     /translation="MESLLILLLIANLAGLFLIWQRQDRQEKHLSKSLEDQADHLSDQ
                     LDYRFDQARQASQLDQKDLEVVVSDRLQEVRIELHQGLTQVRQEMTDNLLQTRDKTDQ
                     RLQALQESNEQRLEQMRQTVEEKLEKTLQTRLQASFETVSKQLESVNRGLGEMQTVAR
                     DVGALNKVLSGTKTRGILGELQLGQIIEDIMTPAQYEREYATVENSSERVEYAIKLPG
                     QGDQEYVYLPIDSKFPLADYYRLEEAYETGDKDEIERCRKSLLASVKRFAKDIKSKYI
                     APPRTTNFGILFVPTEGLYSEIVRNPVFFDDLRREEQIIVAGPSTLSALLNSLSVGFK
                     TLNIQKSADHISKTLASVKTEFGKFGGILVKAQKHLQHASGNIDELLNRRTIAIERTL
                     RHIELSEGEPALDLLHFQENEEEYED"
     gene            complement(28753..29415)
                     /locus_tag="VXE25_000857"
     CDS             complement(28753..29415)
                     /locus_tag="VXE25_000857"
                     /EC_number="2.7.6.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000006147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine diphosphokinase"
                     /protein_id="HEV0771347.1"
                     /translation="MSEYKLSENNWTRVAVFAGGNRGHYRTDFDAFVGVDRGSLWVLE
                     EDLPLALAVGDFDSVTEEERQVIQKRAQYFVQARPEKDDTDLELALLTIFEQNPQAEV
                     TIFGALGGRIDHMLANVFLPSNPKLAPYMRQIEIEDGQNLIAYCSEGTSQLEPRSDYD
                     YLAFMPVRDSQLTILGAKYELTEENFFFKKVYASNEYIDREVSVTCPDGYVVVLHSKD
                     RR"
     gene            complement(29378..30034)
                     /locus_tag="VXE25_000858"
     CDS             complement(29378..30034)
                     /locus_tag="VXE25_000858"
                     /EC_number="5.1.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522408.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribulose-phosphate 3-epimerase"
                     /protein_id="HEV0771348.1"
                     /translation="MSQYKIAPSILAADYANFEREIKRLEATGAEYAHIDIMDSHFVP
                     QISFGAGVVESLRPHSKMVFDCHLMVSNPEHHLEDFARAGADIISIHVEATPHIHGAL
                     QKIRSLGVKPSVVINPGTPVEAIKHVLHLVDQVLVMTVNPGFGGQAFLPETMDKVREL
                     VALREEKGLNFEIEVDGGIDDQTIAQAKEAGATVFVAGSYVFKGEVNERVQTLRKQLD
                     "
     gene            complement(30045..30923)
                     /gene="rsgA"
                     /locus_tag="VXE25_000859"
     CDS             complement(30045..30923)
                     /gene="rsgA"
                     /locus_tag="VXE25_000859"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome small subunit-dependent GTPase A"
                     /protein_id="HEV0771349.1"
                     /translation="MQGQIIKALAGFYYVESDGQVYQTRARGNFRKKGHTPYVGDWVD
                     FSAEENSEGYILKIHERKNSLVRPPIVNIDQAVVIMSVKEPDFNSNLLDRFLVLLEHK
                     GIHPIVYISKMDLLEDRGELDFYRQTYGDIGYDFVTSKEELLSLLTGKVTVFMGQTGV
                     GKSTLLNKLVPDLNLETGEISDSLGRGRHTTRAVSFYNLNGGKIADTPGFSSLDYEVS
                     RAEDLNQAFPEIATVSRDCKFRTCTHTHEPSCAVKPAVEEGTIATFRFDNYLQFLSEI
                     ENRRETYKKVSKKIPK"
     gene            complement(30925..31797)
                     /gene="rsmA"
                     /locus_tag="VXE25_000860"
     CDS             complement(30925..31797)
                     /gene="rsmA"
                     /locus_tag="VXE25_000860"
                     /EC_number="2.1.1.182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA
                     (adenine(1518)-N(6)/adenine(1519)-N(6))-
                     dimethyltransferase RsmA"
                     /protein_id="HEV0771350.1"
                     /translation="MRIADYSVTKAVLERHGFTFKKSFGQNFLTDTNILQKIVDTAEI
                     DDQVNVIEIGPGIGALTEFLAERAAQVMAFEIDHRLVPILADTLRDFDNVTVVNEDIL
                     KVDLAQHIQNFKNPDLPIKVVANLPYYITTPILMHLIESGIPFCEFVVMMQKEVADRI
                     SAQPNTKAYGSLSIAVQYYMTAKVAFIVPRTVFVPAPNVDSAILKMVRRPEPAVAVED
                     ENFFFKVSKASFTHRRKTLWNNLTGYFGKTEEVKDKLTKALDQAGLSPSVRGEALSLA
                     EFAGLADALKGQGL"
     gene            complement(31928..32236)
                     /locus_tag="VXE25_000861"
     CDS             complement(31928..32236)
                     /locus_tag="VXE25_000861"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000333253.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771351.1"
                     /translation="MCEKIRIRRVSDYPSARGGLEDILIMENMTNHLLLVQIRVHGYL
                     LDFASIEGQRQKHYRLKNLPQTVELTVDDVEEDVDLTLPENRSYQEADFFERMFRENC
                     "
     gene            complement(32229..32870)
                     /locus_tag="VXE25_000862"
     CDS             complement(32229..32870)
                     /locus_tag="VXE25_000862"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565534.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0771352.1"
                     /translation="MIDIQGLEKKFNDRAIFSGLNLKLEKGKVYALIGKSGSGKTTLL
                     NILGKLEKIDGGRVLYQGKDLKTIPTREYFRDQMGYLFQNFGLLENQSIKENLDLGFV
                     GQKISKVERLERQVGALEKVNLGYLDLEQKIYTLSGGEAQRVALAKTILKNPPLILAD
                     EPTAALDPENSEEVMNLLVDLKDENRIIIIATHNPLVWNKADEIIDMRKLAHV"
     gene            complement(32872..34902)
                     /locus_tag="VXE25_000863"
     CDS             complement(32872..34902)
                     /locus_tag="VXE25_000863"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000825281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="HEV0771353.1"
                     /translation="MKRLFILISMVLVSLYMVITSVDHREEILFGNYPSVDVTGMMIN
                     QPVASREEVTEALSHLAVEHNSLIARRIVEPNEAGETRFTYATYGEGKLPEGLTISSK
                     ESAETSDLLGSYLIVSGSLDGVSLQTTLKELGYQGFVSNGEDPFSIVLLLTATPMVLL
                     SLAIFLLTFMSLTLIYRIKSLRQAGIRLIAGESLFGVALRPVLEDVRQLICSVLVSSL
                     LGLGILWYQGALFMATVQLVIIALLLYGLTLAGISTLLSVVYLLGLQENSLVDLLKGK
                     LPLKRMMTLMMVGQLLAVLVVGSSATALLPHYREMQEMERASNKWSQSSDRYRLSFGW
                     SSAFADEEGTRKDNREWQTFTEERLANTDSFYIMSNVDNFSDGAEVDLDGNRLSDYTP
                     SGNVIYVSPRYLIEEKITVSSEFIDKMQNLSEGEFGLILPESLREQSAYYQGLFTDYL
                     QNFSSESVEVTSQKHYFPQVRLAFTETGQERFLYNDGYKTTRQYLKDPIIVVLTPQAT
                     GTRPVAGMLWGTTANSALKLDRYGDSITALKEQGLYHKVSYLVKSQLFFAKVLNDKRV
                     EFYSLLIGTILTLSTAILLFDSMNLLYFEQFRRELMIKRLAGMTIYELHGKYLLAQGG
                     VLLLGLVLSSILTRDGLISALVVALFTLNALLILVRQDKKEEAGSMAVLKGK"
     gene            complement(34979..35275)
                     /locus_tag="VXE25_000864"
     CDS             complement(34979..35275)
                     /locus_tag="VXE25_000864"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000815395.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="HEV0771354.1"
                     /translation="MKQTVKKLALVASIAATLGGGVSVASAAVQYPEGGVWTYGSGNG
                     GAYSNYYHPSKYHSSTVVSRKTGSSDKGYAGAGGTSRAWIRTSWGEKVAFYYNV"
     gene            complement(35595..36494)
                     /locus_tag="VXE25_000865"
     CDS             complement(35595..36494)
                     /locus_tag="VXE25_000865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000904853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEV0771355.1"
                     /translation="MLIGQKIKEIRIEKGISRPDFCGDEQELTVRQLSRIESGASQPS
                     LPKLAYIARRLGVPVYSLMPDFSALPSAYLELKYQILREPIYGKEEEYDKKEACLEEI
                     YKTYFDNLPKEEQLACEVLQACLDTSRTRRPEYAELILEEHMPQIIEKEAYSINDMLL
                     IRLFFYQMLIRKDLAKFINQIEKLMLFLLEQKKVTQIENYFIIRDTLISGMCCLEKVG
                     VTDCFNDYLSCLQEIMDKTQDYQKKPLVFMFLWKQALRVERDFSLAESFYQSSKTFAK
                     LIGDEFLVKKLTEEWQEDVKKYL"
     gene            complement(36566..37126)
                     /gene="rnmV"
                     /locus_tag="VXE25_000866"
     CDS             complement(36566..37126)
                     /gene="rnmV"
                     /locus_tag="VXE25_000866"
                     /EC_number="3.1.26.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000660004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease M5"
                     /protein_id="HEV0771356.1"
                     /translation="MKERISQVIVVEGRDDTVNLKRYFDVETYETRGSAINDQDIERI
                     QRLHQRHGVIVFTDPDFNGERIRRMIMTAIPTVQHAFLKRDEAVPKSKTKGRSLGIEH
                     ASYEDLKTALAQVTEQFEHESQFDISRSDLIRLGFLAGADSRKRREYLGETLRIGYSN
                     GKQLLKRLELFGVTLAEVEEAMKSYE"
     gene            complement(37126..37899)
                     /locus_tag="VXE25_000867"
     CDS             complement(37126..37899)
                     /locus_tag="VXE25_000867"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000575597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TatD family hydrolase"
                     /protein_id="HEV0771357.1"
                     /translation="MIFDTHTHLNVEEFAGREAEEIALADEMGVTQMNIVGFDKPTIE
                     HALKLVDEYEQLYATIGWHPTEAGTYTEEVEAYLLDKLKHSKVVALGEIGLDYHWMTA
                     PKEVQEQVFRRQIQLSKDLDLPFVVHTRDALEDTYEIIKSEGVGPRGGIMHSFSGTLE
                     WAEKFVDLGMTISFSGVVTFKKATDLQEAAKELPLDKMLVETDAPYLAPVPKRGRENK
                     TAYTRYVVDFIADLRGMTTEELAVATTANAERIFGLDSK"
     gene            complement(38204..39097)
                     /locus_tag="VXE25_000868"
                     /pseudo
     CDS             complement(38204..39097)
                     /locus_tag="VXE25_000868"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001816585.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1542 domain-containing protein"
     gene            complement(39381..39515)
                     /gene="rpmH"
                     /locus_tag="VXE25_000869"
     CDS             complement(39381..39515)
                     /gene="rpmH"
                     /locus_tag="VXE25_000869"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L34"
                     /protein_id="HEV0771358.1"
                     /translation="MKRTYQPSKLRRARKHGFRNRMSTKNGRRVLAARRRKGRKVLAA
                     "
     gene            complement(39660..40874)
                     /locus_tag="VXE25_000870"
     CDS             complement(39660..40874)
                     /locus_tag="VXE25_000870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011836593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HEV0771359.1"
                     /translation="MKEYNKSSKLEHVAYDIRGPVLEEAMRMRANGEKILRLNTGNPA
                     EFGFTAPDEVIHDLIMNARDSEGYSDSKGIFSARKAIMQYCQLKKFPNVDIDDIYLGN
                     GVSELIVMSMQGLLDNGDEVLVPMPDYPLWTAAVSLAGGNAVHYICDEAVEWYPDIDD
                     IKSKITSNTKAIVLINPNNPTGALYPKELLLEIIEIARQNDLIIFADEIYDRMVMDGH
                     VHTPVASLAPDVFCVSMNGLSKSHRIAGFRVGWMVLSGPKTHVKGYIEGLNMLSNMRL
                     CSNVLAQQVVQTSLGGHQSVDELLLPGGRIYEQRNFIYNAIQDIPGLSAVKPKAGLYI
                     FPKIDRNMYRIDDDEQFVLDFLKQEKVLLVHGRGFNWQEPDHFRIVYLPRVDELAQIQ
                     EKMTRFLKQYRR"
     gene            complement(41030..41324)
                     /locus_tag="VXE25_000871"
                     /pseudo
     CDS             complement(41030..41324)
                     /locus_tag="VXE25_000871"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009014348.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            41486..41938
                     /locus_tag="VXE25_000872"
     CDS             41486..41938
                     /locus_tag="VXE25_000872"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000079155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="universal stress protein"
                     /protein_id="HEV0771360.1"
                     /translation="MAQRYQNIMVAIDGSKEADLAFVKGVHSALRNDAKLTIAHVIDT
                     RALQSVSTFDAEVYEELQVDAESLMKEYEKRAKDAGVADVHIVIEMGNPKTLLARTIP
                     DAEEVDLILVGATGLNAFERLLVGSSSEYILRHAKVDLLVVREQEKTL"
     gene            complement(41973..43361)
                     /locus_tag="VXE25_000873"
     CDS             complement(41973..43361)
                     /locus_tag="VXE25_000873"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000453140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEV0771361.1"
                     /translation="MEVKAVFFDIDGTLVNNRKSVLKSTKDAIKIVKEQGVLVGVATG
                     RGPFFVKELMDDLDLDFAVTYNGQYIFSKDRVLFTSPISKLHLRHLISYAKKEGTEIA
                     LGTKDAMLGSKIMSFGLGSFSQRISRFVPSVLTRTVSQSFNRMVSKVVPQKEEDLLHL
                     MNQPIYQVLMLMTPEESEKAAADFEDLKLTRSNPFASDVINQGNSKLEGIRRVGKEYG
                     FDLNQVMAFGDSDNDLEMLAGVGMSVAMGNGSSSVKEAAKHITTSNQQDGIHKALEHF
                     GVLSSEKVFVSRDYHFNKVKTFHHMMDERTQEEPRAWDLEGATHRAGFKIEELVEFVR
                     AASPSEEDFGQAVSQLHQALDKAADKVAKKTPAQQDLIGQVDALIDTLYFTYGSFVLM
                     GVDPERIFDIVHQANMGKIFPDGKAHFDPVTHKILKPDNWEEKYAPEPAIKKELQRQL
                     KAYERHKERNKS"
     gene            43427..44389
                     /locus_tag="VXE25_000874"
     CDS             43427..44389
                     /locus_tag="VXE25_000874"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparaginase"
                     /protein_id="HEV0771362.1"
                     /translation="MPKKILVLHTGGTISMQADASGAVVTSSDNPMNHVSNPLEGIQV
                     HALDFFNLPSPYIKPKHMLVLYQKIKEEADNYDGVVITHGTDTLEETAYFLDTMEVPH
                     MPIVLTGAMRSSNELGSDGVYNYLSALRVASDDRAADKGVLVVMNDEIHAAKYVTKTH
                     TTNVSTFQTPTHGPLGLIMKQEILYFKTAEPRVRFDLDHIQGLVPIISAYAGMTDELI
                     DMLDLEHLDGLIIQAFGAGNIPKETAQKLESLLQKGIPVALVSRCFNGIAEPVYAYQG
                     GGVQLQKAGVFFVKELNAQKARLKLLIALNAGLTGQALKDYMEG"
BASE COUNT        12657 a        10146 c         8607 g        13051 t
ORIGIN      
        1 aaaattacat aaaaatgctt gaccgaataa tatatatata ttaaaataaa aacaaggaaa
       61 aagaaaaggg tttcacgaat gaagaaaaat cgtggaattc aaaaattagc tatattagta
      121 ttactaggtg tttttatgtt tagtaacaca attccttacc aacagtttat tcagaagaat
      181 agacaattgg agattcgagt gcaatcacaa aagaagtcca atggtcttga tgttgtgaag
      241 gctgattgat ttcgtattac tttaaaattc aactatttag agaaaggtat tctgatgaga
      301 gcttgtaaca ataccagata gatataagaa tggagatgtt tgataaaatg ctttcatagc
      361 taaccaactg ttgaaaatta tgagttacaa aatctaaagt atttaagatt ggtttataaa
      421 attaggtctc tgcctgtaga aaggaacgtg cagttagaaa ggaggaaaaa ataggatact
      481 ataattcaga ctgagatttc taattaaaat atgtagttgc atttcgctca ttttcataat
      541 atttcattca gaggagtaat aatatgttaa aatttagatt tgatgcggga tggtaaagaa
      601 taattgaaga agattctttt atcaatagtt tagtaagctt gttagtttat agagggcagg
      661 ggtatttctg ccctctgttt tagaataagg aatgcactat gaaaaaatta tttatactca
      721 tatccaacct gcttgctagt ttgttctttg tttgggtatt taccatttgg actgatacat
      781 atgtctccta ttattacccc aacgttgttg tacatgattc ttcccctgaa acaacttttc
      841 agcatgttgc tacacgcttg gaaaaactag cagaagaaac agatagcttt attgcgattc
      901 aacaccaaga tcctaactca gaaggtacta cagttttttc ttatacgacc tttggggacg
      961 gaaagttgcc tgatgggctt caggaaaaaa atctagaaga tgctcaaagt agtagtgttg
     1021 aaacaaacta ttttgtattc gatggacacc tagatattca cttgctaagg gaagagctaa
     1081 gtcaacttgg cttgactaac atgcacctga caattccatc taaactatct acgttaatgg
     1141 ctatctttag taacggattt cagttaatca gtctattgat tttcatctta acctttgtag
     1201 cactgacttt aattagtcaa attagccaat tacggtcatc gggcattcgc ctcatttcag
     1261 gagagaaacg gtggtccatt ttccttagac cagttggtga ggatttgaaa gggatagctg
     1321 ttggtttcag tttagctggc gtgctcgcca ttcttatgca aaaaattctg tcgcttccaa
     1381 cgcaatccct aatgaccata ggagcaggct tgctcagtta taatctcatc ttgttgtcga
     1441 tctccctgtt tttcgctcaa ctcttcgcag ttgggataaa aaagatacac ctgatgcaga
     1501 ttataaaagg gcaagtgcct gtcagaggaa tcattagttt gattttaatc ggtcaactgt
     1561 tagcgattat tattgtaacg ctgggaatag ggagtagctt aaagtattcc caagcctggc
     1621 aacagcatcg gattggacaa gaggtttgga gtcaggaaag acaactgatt accctatcaa
     1681 tcagccgtga aggaacgagt cctggttttg atgaacaagc tcaaaggaaa ctcagaactt
     1741 ggtatcaatt gatggatctg gctgtttcag aacaaaaggc tttcttatct agacaccagt
     1801 taattgaccg tactttgcaa aatggcatgg cttcctccaa aaacttgaca acctctacag
     1861 aatggcacga ttacagcccg aatggcaatg tccttatcgt cacaccgcat tacttggagc
     1921 gtcaaaacat tcctgtagat acaactatta agcaaaagat gaatcacctt aatgtagggg
     1981 agtttgtctt attgctgcct gaacacctcc gttcagagga agaacattat aaatctgttt
     2041 ttgaagacga cttaaccagt cgcatgtcta gtcaagatga acgacagcaa atgactgcta
     2101 cggtaggtta tttagaatca ggtcaggatc gttttgtgta taatacgacc cctatttctt
     2161 accagcagtt tttgaaagat ccaatcatca ttgttataac accccaatca actggtccac
     2221 agtccatttt gttttggata gacgcagtac agaactacgt tctctttaat caattgtctg
     2281 atgcccagga gcttatccag agacaaggca ttgaaaattg ggtctcagaa atgcaaacag
     2341 gttaccacaa ctacatcaca ttattggata atatccagag ggaacgttgg gtaatgctag
     2401 caggagctgt gcttgggatt gcaacttcaa tcttgttgtt taacactatg aataggctct
     2461 actttgaaga atttagacgt gccattttta tcaaacgcat tgcaggtctc aggttcttag
     2521 aaatccatcg cacttatctc tttgctcaac tgggtgtgtt tttactggga tttgttgcga
     2581 gtgtatttct tcaggtagag ataggagttg ctttcttagt cttgttactc tttactggtc
     2641 tatctctttt acagttacat gtccaaatgc agaaagaaaa caagatgtcc attcttgttt
     2701 tgaagggagg ttaatatgat tgaacttaaa caggtgagta aatcttttgg agaacgagag
     2761 ttattttcga atctttcaat gacatttgag gctggaaaag tctatgcctt aattggttca
     2821 agtggtagcg gaaaaacaac cttgatgaac atgattggga aattagaacc ttatgatggg
     2881 acgatttttt accgaggtaa agacttggcc aattataaat cgagtgattt tttccgtcac
     2941 gaattgggct acctcttcca gaactttggc ttaattgaaa accaaagtat tgaagaaaac
     3001 cttaagctag gtctcattgg tcaaaagttg agtcggtcgg aacagcggtt gaggcagaag
     3061 caggctttag aacaggtcgg cctggcttat cttgacctag ataagcgcat ctttgagtta
     3121 tcgggcggag aatcgcaacg ggttgccttg gcaaaaatta tcttaaagaa tccacccttt
     3181 attctggcag atgagccaac agcttcaata gacccagcaa cctctcagtt gattatggag
     3241 attttgctat ctcttcgaga tgataatagg ctaatcatta tcgcaacaca taatccggca
     3301 atttgggaga tggctgatga agtgttcacg atggatcatc tgaaataaaa atccttgttt
     3361 ttaattgcac gatgagttac tgaaatatta tcatgaatca ataattggag ttaatttaga
     3421 attgtacttt attaatattg aggtaacttt ttcttgataa aggaagaaat aatggagagg
     3481 aagttagaat gaaaaaattc gacaattata ttattgagaa gccttgcgat tctaattcag
     3541 ataaactgca aaaaatctta ataattgaaa gtttggtaga tgatattttg caattttctc
     3601 tcagaatcaa taatagtgta ggagagattt tcctcctaca accgttttaa aagaaaacta
     3661 tctttattcc atgttatttt gaggaagata ttgtgaaagt caaagatgat gataaagttg
     3721 agtggaattt gttagaattt caaaaattta gagcattttt ggcttagtaa tctgtgttga
     3781 aggctcaaaa cctatggtaa aaaagtcgct ttgaaaacgt attgcctcca aagatttagt
     3841 taaataatga tttaacacaa aaagaaatta ttgaagttct ggaaagatgt tgtttcagta
     3901 ttgagaaaag gtgggaaaaa cttgcgattt tcacagagaa aggaagaaaa agtatagaaa
     3961 tatagtcaat tgaaacaaga acaggacaaa agaacctttt gtgccatatt tttctccttt
     4021 cgctttacaa ttggcttgaa cacctttatt gtatcgcgtt tggagttttt ttggtataac
     4081 cttcgacgcg cacccgcata gcgggtgttt ttttgtctcg cacctaacgg agcgagacga
     4141 actaatagtc acttaatcaa aaactaaaaa gtttgatatc atgcgtcatg tcttaaacta
     4201 attgactata ctttctattc aaatgagctt ttaaccaatt gattgagcca atccactctt
     4261 aaaaccaaag agcaatttct cgcttagctg actcttctga atctgaacca tgtacaacat
     4321 tttggataac ctcattttct ccagcagctt ttgcaaagtc acctcgaata gtgcctggta
     4381 aagattcttc tggacgagtt gcacccatca tggtccgcca agtttcgatt actttgggac
     4441 cagaaatgac acccacaaga actggacctg aagtcatgaa ttcacgaatc ggtaggtaaa
     4501 aactctgacc aaccaagtcc tgatagtgct ggtcaatcaa ctcttctgaa acctgtgaac
     4561 gaaactccaa tttttcgatt gtaaatccac gttgttcgat gcgctttaac acttcaccca
     4621 ctagccctct ttttacacca tctggtttga tgataaagaa tgtttgttcc atacccgtct
     4681 cctttgtcag cttctttctt ttattttacc acatttcgtg gaaaaatgga gaaagttttc
     4741 agaagagaga atgagagaac ccgagggttc tctcattctc tcttattcta ctgtttcttc
     4801 cacagtttca acggcagtat ccacaactac ttctgttgtt tcttcatttc cttcttcctc
     4861 tactggagga ttaaggtatt cttcttcgtt gacagcatgt ggttcaaggt tacggtaacg
     4921 ggccatacca gtaccagctg ggatgatctt accgatgata acattttctt taagtccaag
     4981 gagatggtct ttcttaccac ggatagctgc gtcagtaagg acacgagttg tttcttggaa
     5041 ggaagctgct gacaagaaac tgtttgtttc aagtgaggct ttggtaattc ccataaggac
     5101 tgggcgacct gtcgctggaa ctccacctgc gataaggaca tctttgttgg catctgtaaa
     5161 gtcattgata tccatgaggg tacccatgag aagatctgta tcacctggat ccatgacacg
     5221 gactttacgg atcatttgac gaaccattac ctcgatgtgt ttgtcaccga tttctacccc
     5281 ttggctacgg taaacttttt gtacttcacc gagaaggtac gtttcaactg acaagacatc
     5341 acgaactgca aggagacgtt ttggttggat agaaccttct gtcagagcag caccacgcgc
     5401 tacttggccc ccaacttcga cacgcatacg agctgtaaat ggaacgacat attcaccttc
     5461 gccagtttca cccttaacaa agactttctt ggtacgagtt gatgcatctt cttcgatagc
     5521 agtaacttgt cctttaacct ctgtgataac cgcttcccct ttaggattac gggcttcaaa
     5581 gatttcttgg acacgaggaa gaccctgagt gatatcggta tttgaggcaa ccccacctgt
     5641 gtggaaggta cgcattgtaa gctgtgtacc aggttccccg atagattggg cagcaattgt
     5701 accaactgct tcaccaactt caaccgcatc accagtcgcc aagttgatac cgtaacagtg
     5761 acggcagaca ccgtgacgag tgttacatgt aaatacagaa cggatagtca cttcttccac
     5821 accagcattg acaatttcac gcgccttgtc ttctgtaatc aattcatttg gaccaataat
     5881 cactgcacca gtttctggat gtttaacagt tttcttagtg taacgaccgt tgagacgctc
     5941 ttcgagagac tcgatcatct cttttccttc tgcgatagaa cggatcaaga gaccacggtc
     6001 agttccacag tcgtcctcac ggatgataac gtcttgggca acgtcgacca aacgacgagt
     6061 caagtaacct gagtcggctg tcttaagggc cgtatcggtc atacctttac gagcaccgtg
     6121 agttgagaag aacatttcca ataccgacaa accttcgcgg aagtttgaaa ggattggcaa
     6181 ttccatgata cgtccattcg gagcagccat cagaccacgc ataccggcaa gctgtgagaa
     6241 gtttgagatg ttaccacggg ctccagagtc catcatcata acgattgggt tcttaggatc
     6301 ttggttagca atcaagcgtt tctcaagttt ttcacgggca gcacgccatt cagctgtaac
     6361 agcattgtaa cgctcgtcgt ctgtgatcat accacgacgg aattgtttgg tgatttgttc
     6421 gacacgtttg tgtgattctt caatgatttc agtcttgtca tcaacgactg ggatatcggc
     6481 aatacccact gtcaatcctg caagagttga gtggtggtaa ccgaggttct tcatgcggtc
     6541 aagtagggca gaagtttctg tcgtacggaa acgtttgaag atttcagcga tgatatttcc
     6601 aaggtttttc ttcttgaatg gagggttgag ctcaagattg ctgatagctt ccttgatatc
     6661 tccaccaagt ggcaagaagt atttagctgg aacaccttct gtcaagttgg cattgtttgg
     6721 ttcttgcaag tatagtagcc cctctggcat gatatcgttg aagagaattt taccaactgt
     6781 tgtaagcaag accttatgtc tttgctcttc tgtccaaggc ttgttgaggc tgtctgttgc
     6841 gataccaaca cgtgagtgga ggtgaatata accattgcgg taagccataa ccgcttcgtc
     6901 acggtctttg aagaccattc cttcaccttc gcgaccagct tcttccatgg tcaagtagta
     6961 gttacccaaa accatgtcct gagatggagt aactaccggt ttcccatctt tcgggttcaa
     7021 gatgtgctca gcagctagca tgaggatacg agcttctgct tgtgcttctt ctgaaagtgg
     7081 tacgtggatg gccatttggt ccccgtcaaa gtcagcattg taggcttcac agacaagtgg
     7141 gtgcaagcga agagccttac catcaatcaa gactggctcg aaggcttgga tacccaaacg
     7201 gtgaagggtc ggtgcgcggt tcaaaagcac tgggtgttct ttaatcactt cttcaaggat
     7261 atcccagata cgctcatctc cgcgttccac caagcgttta gctgctttga cgttttgcac
     7321 gatatcacgg gcaacgattt cacgcatgac aaatggttta aagagttcaa tcgccatttc
     7381 acgcggcaca ccacattggt acatcttaag agttggacca acggcgataa cggaacgtcc
     7441 tgagaagtca acacgtttac cgagcaagtt ttgacggaag cgtccctgtt tacctttaag
     7501 catgtggctc aatgatttca atggacggct acctggtcct gtgattggac gaccacgacg
     7561 accattgtca atcaaagcgt caactgcttc ttgaagcata cgcttctcat tttgaacgat
     7621 gatacctggg gcatttaact caagcaaacg agccaaacgg ttgttacggt tgataacacg
     7681 gcggtaaagg tcattcaagt cagatgaggc aaaacggcca ccatccaact gcaacattgg
     7741 acgaagatct ggtgggataa ccggaaggat gttaagaatc atccattcag gtttgtttcc
     7801 agacttgtaa aaggcatcca aaacatccaa acgacggatg gctttgacac gtttttgtcc
     7861 agtagctgtt ttcaattctt ctttgagttc agcaatttct ttttcaagat ctacttgctt
     7921 caaaaggtct tggatggctt ccgcacccat cttggcaaca aatgaaccat aaccatattc
     7981 acgcaagcgc tctcggtatt cgcgctctgt catgatagac ttgtgctcaa gtggtgtatc
     8041 cttaggatca atcaccacat aagccgcaaa gtagataact tcctcgaggg cacgagggct
     8101 catatcaagg gtcaagccca tacggcttgg aatccccttg aagtaccaga tgtgagatac
     8161 aggagctttc aactcgatat gtcccatacg ctcacgacga actttcgtac gcgttacttc
     8221 aaccccacag cggtcacaaa caattcctct gtaacgaatg cgtttgtact taccacaagc
     8281 acattcccag tcttttgtag gaccaaagat cacttcatca aagagtcctt cacgttctgg
     8341 tttcaaggta cggtaattga ttgtttcagg ttttttgact tctccataag accatgaacg
     8401 gactttactt ggagaagcta gggtgatttg catactttta aaacgattta catcaaccac
     8461 tatttcttcc ctttctattc taagtgaact gcttattcct gttcagcagc ttcttctgtt
     8521 gcttccgctt ttgttgcttt ctcagcttct tcagcttcaa aggctgcttt agcctcttgg
     8581 gctgcttttt cgcgggcttt ttcaaggtca tctacgtgga tgacatcttc gtccattcct
     8641 tcatccaagt cgcgaagttc cacttcttgg tcatcttcgt ctagaacacg catgtcaaga
     8701 ccaagagatt gcaattcttt gacaagaact cggaaggatt ctggaacacc tggttttgga
     8761 attggtttgc cttttgtaat agcttcatag gctttcaaac gtccgttgat atcgtccgac
     8821 ttgtaagtca agatttcttg aaggacattt gacgcaccgt aggcttcaag agcccaaacc
     8881 tccatctcac cgaaacgttg tccaccaaac tgagctttac ctccgagtgg ttgttgggta
     8941 acagttgagt aaggtccgac tgaacgcgcg tgcaatttat catcaaccat gtggtggagt
     9001 ttgatcatgt acatgactcc aacagaaaca cggttatcaa atggttcacc tgtacgtcca
     9061 tcgtaaagga ttgtcttggc atcgctatcc atacctgctt ctttaacagt tgaccaaaga
     9121 tcttcagaac ttgctccatc aaagactggt gtcgcaatgt gaataccaag agtacgagct
     9181 gccataccaa ggtgaagctc cataacctga ccgatattca tacgtgatgg caccccaagt
     9241 gggttcaaca tgatgtcgac tggagttccg tctggaaggt aaggcatgtc ttctacagga
     9301 acgatacgag agacaacccc tttgtttccg tgacgtccgg ccattttatc tccgacctta
     9361 atcttacgtt tttgagcgat gtaaacacga accaacatgt taacacctga ttgcaactca
     9421 tctccattta cacgtgtaaa gatcttaaca tcacgaacga caccatcggc accgtgtggt
     9481 acacgaagag aagtatcacg cacttcacga gacttgtctc caaagatagc gtgcaagaga
     9541 cgttcttcag ctgaaagatc tttctcaccc ttaggtgtta ctttacctac aagaatatca
     9601 ccttctttaa cctcagcacc aatacggata atccccattt cgtcaaggtc tttgagggca
     9661 tcttcaccaa cgtttggaat ttcgcgagtg atttcttcag gcccaagctt tgtatcgcgc
     9721 gtttctgatt cgtattcttc aaggtgaaca gatgtgtaga catcgtcctt caccaagcgt
     9781 tcgctcatga taacggcatc ctcgaagttg taaccttccc aagtcatgta ggcaacgatt
     9841 gggttttgtc caagcgccat ttctccattt tccatagaag gtccgtcagc gatgaaatcg
     9901 cctttttcaa cgacatcacc aacttttacg agagtgcgtt ggttgtaagc agtacctgag
     9961 tttgaacgac ggaatttttg gatgtggtaa acatccaatg aaccatcttc acgacgaact
    10021 tctaccttgt cagcatctgc gtaagtaact ttaccatcat actgagcaat cacagccgca
    10081 ccagaatcgt gggctgcttg gtattccata ccagtaccaa cgtaaggtgc ctgaggatta
    10141 atcaatggca cagcctgacg ttgcatattg gctcccatga gggcacggtt ggagtcatcg
    10201 ttttccaaga aaggaataca tgctgtcgca acggcaacta cctgttttgg tgaaacgtcc
    10261 atgtagtcaa caatattagc tggatactct tggttgaccc cttggtgacg tcccatgaca
    10321 atcttctcag caaaggttcc atcttcattc agacgagagt tagcctgagc tacagtatat
    10381 tcatcttctt catcagctgt caaccaaaca atttcgttcg tgacaacacc tgtttcacgg
    10441 tcaaccttac ggtatggtgt ttgaacaaaa ccatatttgt tcaagtgtcc gtaagatgac
    10501 aagttattga tcaaaccgat gttaggtcct tcaggtgtct cgattggaca catacgacca
    10561 tagtgagtgt agtgcacgtc acgcacttca tatccggcac ggtcacgagt caaaccacca
    10621 ggtcctaagg ctgacaaacg gcgtttgtga gacaactcag aaagcgggtt gtgttggtcc
    10681 atgaactgtg acaactgtga tgaaccaaag aattctttaa ctgcagctgt tacaggacga
    10741 atattgataa tttgttgtgg tgtcaagact tcattgtcct gaacagacat acgttcacgg
    10801 acattacgtt ccatacgaga aagtcccaaa cgtacttggt tggcaagcaa ttcaccaacc
    10861 gcacggatac gacgatttcc aaggtggtcg atatcatcta cacggccaag tccttcagcc
    10921 aagttgagga agtagctcat ctcagcaagg atatctgcag gagtcaccgt acgaaccttg
    10981 tcatctgggt tagcattacc aatgatcgtt acgacgcgat ctggatcagt tggagcaata
    11041 accttgaatt tttgaagaac aacaggctca gtcacaacgg ctgcatcgtt tgggatgtag
    11101 acaatcttgt tcaagtcgcc atccaaatgg ctttcaatgc tttcaatcac gctacgagtc
    11161 ataatcgtac cagcttctac caagatttct ccagtttcag ggtctaccaa tggctctgca
    11221 atggtttggt tgagcaaacg tgttttaaca ttgagttttt tattgatttt gtaacgacca
    11281 actgctgcca agtcataacg acgtgggtca aagaagcgag ctacaagcaa gctacgtgag
    11341 ctttcagccg tcttaggctc acctggacga aggcgttcgt aaatttcttt caaggcttcg
    11401 tctgtacgag agtccattgg attcttgtgg atatcttttt caacagtgtt gcgaaccaat
    11461 tcgctgtctc caaagatatc aaagatttca tcatcacctg agaaaccaag agcacgaacc
    11521 aaggttgtaa atggaatctt acgagtacgg tcgatacgag tgtaggtgat atcttttgag
    11581 tcgctttcaa gttccaacca agctccacgg ttagggataa cagttgaacc atagcccacc
    11641 ttaccatttt tgtctacttt gtcgttaaag taaacacctg gtgagcggac caactgagaa
    11701 acgataatac gttcaccacc attgatgatg aaagtaccca tttctgtcat gattgggaaa
    11761 tcaccaaaga aaacttcttg ggtcttgatt tcgcctgttt ctttattgat caaacggaag
    11821 gttacaaaaa ttggtgctga gtagctagca tcgtggatac gagcttcttc tagcgtgtat
    11881 tttggttcct tgatttcata tccaacaaat tccaactcca ttgtgtctgt gaagtttgaa
    11941 attggcaata catcttcaaa cacttcctta agaccgtggt ctaggaaagc tttgaatgag
    12001 tcagtttgaa tttcaatcaa atttggtaag tcaagaactt ctttgattct tgaaaaacta
    12061 cgacgggtac gatgtttccc gtattgaacg tcatgtcctg ccaagatgat tctcctttgt
    12121 aaataagttc caagccttgt caatcaggct tttctaatcg tcatatggtt gtaaacccct
    12181 tatcaccgtg tcctcttgac gaattttcag aatctttaag cctctgttac aaatgctcat
    12241 aatcttgaaa aaaagcacaa aaagagcagc taaatctgac tttttcagaa gatttaactg
    12301 ctgtgagcct tgtctggaca atatttcaga caaaacctac gacaaatgat tacccatatt
    12361 ataccctatt tagctagatt tttcaagggg tttcagtagg tttttggtaa attttttccc
    12421 atagaaaact tggcatcaca ttcgaatcac gctatggtac aaaaaactga aaaaactatt
    12481 gactgaaaat cattttcaag gtataataat aaacgttaag gcggtatagc caagtggtaa
    12541 ggcacggctc tgcaaaagct tgatcgtcgg ttcaaatccg tctaccgcct tctataactt
    12601 gatttatcag gtttcaaatg aacagaaagc ccaatttgaa gggctttttt tattttccct
    12661 cgaataaata cgtataactt taaaaacttt tggagcgagt ttgtggcaga gttctttcca
    12721 tggcataatt cccttttgaa atcaattgaa aaaagcttcg tcacgcctgg tgacaaaagc
    12781 ctctagttta ttctgtttct tcttctattt cgacttctgt gatttggact tttaccttgg
    12841 taacacgtcc attcttcact ttatcattgg ttaagataaa ctgtttgttt tggctgacca
    12901 attcatagct gagtttctca gtcgttggaa tggttcccac tcctgtcaaa taataaccag
    12961 cgatggtatc aacgtcatca ctttccagct caacatcaaa gtaattattg aaatcattga
    13021 gggtcatagt tccttgaaca atgtaggtat cctcgccaat ctgatgaaca tctattgctg
    13081 ctttgtccgt ttcatcatca atttcaccaa caatttcctc taagaggtct tccaaagtca
    13141 ctaaaccagc cataccaccg tattcatcca gcaagattgc catttgtctt tgggtatttc
    13201 gcagttcttt tagcaagtca tccacaaaaa tagtttcagg tacaaaaagt ggatcttgta
    13261 aaattctctt ccaaacaata ttgtcaaaac cgtccacaaa gcctgcctta aggagactct
    13321 tggtgtgaat gattccaatt acattgtcct tatccccatc ataaaccggg atacgagaat
    13381 aattttgttt taaaatactt tggataatgg cttgactatc atcctgaata tccaccataa
    13441 aggcatctgt tcgaggaacc ataacctctc gtgccatcag ttcatcgagc gaaaagacac
    13501 cttgtagcat ctcaatctca tcagcatcca atgtttcttc actatttgtc agcatatagg
    13561 caatttcatc acgggtcatt ttttcatccg catcatcgaa tgacatagga gtcaaatggc
    13621 tcaagaaatt ggtcgaagca gctaaaagcc aaacaaaagg actgactagt tttccgatcc
    13681 caatgataac cggcgctgta cgaattgcca aggcatcctt tagattaaga gcgattctct
    13741 taggatataa ttccccaaaa acgatggaaa tataggtcaa aaatgccaag gatagaaaag
    13801 ttgccacggc ttgtgctgtt tcgccattcc caagccaaga ggcaatcaca cgtcctagag
    13861 tatcagttaa actcgcccct gataagattg taatcagggt gattcctacc tgaatggttg
    13921 ataaaaagtg gttaggattt tctagtacct tcagcaggcg gatgtagcgt ctgtctcctt
    13981 cttccgcctt ttgttcaact cgggcacgat taagagaaac catggccatt tctgtggctg
    14041 agaaaaaggc atttaatacc gtcaagataa acaataaaac aaattgtagc aacaaattct
    14101 gactacttgg gtcttccata gttcttctcc taaaatagta tcttatccct tattatatca
    14161 caaaatttaa tccaatacat attatttttt tcttagcgta acttccatct ctctcccaaa
    14221 actggaagtt aggctaagac ggatttccac tgatttcacg cgtttttctc atactaaaag
    14281 ctaggttgtg ggaaactgga agttagtttt agaagttact attttttctt agtacctgtt
    14341 ctaaccctgc ttaaactagt aaaaagaact cctacatcca taagtgacat aggagtttag
    14401 gcttatcttt tactgagtta cagttacttc tccagttcgg taatccagtt gaagtccctt
    14461 ttgaacattg ggaactagaa cattgaattc caattctcca tccgaagact tggcttcaat
    14521 ctgtgaagct gagggaacta aatcctcgtt tgaagcgtag taaagggtta cacggtaacg
    14581 gacacgcttg ttttggtcca aggctttacg caccttgctt tcatagtagt tttgaccagt
    14641 cgaatactcg gcttgtgcct gatttgccca ggctgtctga acagcaatgt ttttaggatt
    14701 gcttgttgag gcatcaaaac catccaaacc accgattaag gcatagccta acaaatgacc
    14761 tctatcgact gcatgggtat aagagccctt tagattcttg acctgatgcc aacctggagg
    14821 agtccaagaa gttgaaccat tcccagtttc tttacgattc ttgtactgac gagtggcctt
    14881 agacaagagg gcattagcta cggttggaac agtttccttg cccactgtct ttgttttatt
    14941 gtcagcgtag ggcttacttg aaaccttggc atctagattt gttttattac cattgacgat
    15001 aaaagcacct gagccattcc actccagact cccctttatt tgactcttga ctgcgtctgt
    15061 taagacactc tctgccaatg cttgactagg agcttcagac gcttgttttt tctgactaag
    15121 cttggtttta ggactattag ctgtcgactg catctgcttg atataatagc tccctgtaga
    15181 caaaagcaat aacactagca gtccgattag tgtctgtctt gtttttttgt tcatatttct
    15241 ccttatcttt agaaaaaggc tggttctcca gcctaatttc ctgtaaattt atgaatcaat
    15301 tcctgccatt ttgctggaga caggatagcc catggatctt gacccttgcc caagattcca
    15361 taacctacca ttaaaccgat tcctagagcc agagtaccta aaatcagtac tatgatgact
    15421 aaaagtaaac gcttgactac gtagcttgat ttcttattca tcttcatcac ttgcctcaat
    15481 ccgctgaatc ttagcaccta gctgcgccaa cttctcatgg aaaccgtagt aacctctatc
    15541 caagtgaacc aatttaccga ccacagtttc tccctgtgct accaaacctg tcaaaatcaa
    15601 ggccgcactg gcacgaaggt cagttgaaag aacttctgct ccctgcaaag gctgtccacc
    15661 aacaatacga gctgtatcac ggataatctc agaatgcaag cccatgcggc gcatctcttc
    15721 taggtgttgg aaacgatttt caaaaactgt ctccaccatg gttgattcgc cttttgcaac
    15781 tgtcatcaag gctgtaaatt gagcctgcat atctgttgga aatcctgggt ggggcaaggt
    15841 tttcacatga acagctttta gattttccag ttgagaacga acacgaattc cttcgtcttc
    15901 ttcaattact tcaacaccca tttcaagtaa cttggcaatc aagggacggt tgtgctccca
    15961 gacagcgtct cgaatcaaga catcaccacc agtcatggca gcagctacca taaaggttcc
    16021 tgcttcgata cggtcctgga ctacattgtg agtcgtacca tgaagtttct caacaccagt
    16081 aatggttata gtctctgtac cagcaccttt gaccttggct cccatttcat taaggagaat
    16141 ggctaagtca acaatctcag gctcacgcgc agcattctca atcactgtca ccccatcagc
    16201 cagagtcgct gccatcatca agttctgcgt tgcaccaaca cttggaaagt ccatatagat
    16261 atgagcgcca tgcaagcgtt ctgccttggc ttcgatgtaa ccagctgtct gactaacctt
    16321 aacccccata gcttccagac ctttcaaatg aagatcaata ggacggctac caatcgtaca
    16381 accacctggc atggatacct tggcatgacc cacacgggca aggattggcc ctaatacaac
    16441 gatggaggcg cgcatcttgc tgacatactt gtaaggggct tcctcagtga tgtcgccagt
    16501 agcatccacc ttgacaagat gagcttcctc atcaaagtca accttggcat tcaaaccacc
    16561 aactacctga ttcataataa agacatccga caaaatcgga acattctgca agacggtctt
    16621 tccttcactt gctagaatag tcgctgccaa caagggtaag actgcatttt ttgctccctc
    16681 gatcgtcacg cttcctacca gacgattatc gccaccttga accacaattt tatccatact
    16741 cgtttccttt actcttgatt ttataataat cctctaagcg cttcttgcca caaatgatac
    16801 aggctaataa agaaagaact caggatgtag cctatgacaa tgctaaaaaa ggctactaat
    16861 aaacgaactt ttcttgtatt ctcagctgtc acttttaaaa ccttttccca tctaacaaga
    16921 tcctttaaaa ggtaaaaact cacataaata aagagcatat gactacttag agtgaataat
    16981 aattgaacca tttgactatt ataccatctt ctctgtttgt gcgctagttt ggaaacttca
    17041 ctcaaaaatt agggattgtt tttcaagtaa tcaatcgcat cttgtagggt tttaacgggc
    17101 acgattttca tatccgtctt gattgtttta gccgcttcta gggctgtttg gtagttgttt
    17161 ttcgcgtccg gatgcgcctt ttgttcttct tcgctaacag ggttatcagg agcaaagaaa
    17221 atagcagcac ctgccctagc cgaagctaca accttcttat caatacctcc aatgtctccc
    17281 acattaccat cgcggtcaat ggtacctgta ccggcaacaa tacgaccatt acgaagatct
    17341 gggtgagcta tttgagtata gatagctaga ctaaacatga gaccagcact tggaccgcca
    17401 ataccagctg ttgaaaagct aattgggaca ttgctgatta cctctgtacg gtcaatcaag
    17461 ccgattccaa ttccattttt gccattttcc aaggtgataa tctttccttc tgcagacttg
    17521 gtttgcccat cctcttcata ggtgaccttg acggagtccc ctaatttttg agaactgacg
    17581 taatcaatca agtctttgga actatcaaag gtctgatcat tgactgctgt gactgtatca
    17641 gagatattga gaatcccttt aaaggttgaa ttatccgtca cattcaaaac ataaactcca
    17701 aagtacttga gttcgatttc cttaccagct gtttttagtc cttgatactt ggccatattt
    17761 tgcgatgttt gcatgtagaa ttgattgatt cgcataaatt caacatcgga agaaccacct
    17821 gtagtctcct gagcactacg aatatctgta aaaggtgtca accaagcata aatcatatga
    17881 gctaaagtag catgttgaac accaaccgta acgaattgat aggcaccagc ttccttatct
    17941 tctgtgtcat ttactttaag gacttggcga atatcttccg aaccacctgg aacctctata
    18001 tagtagggca aaggcaccac aaatgccaag aaggtcacaa tcaaggccgc aatgacatac
    18061 aaaggccatc taatcttttt tttcatttct tatttcctcc aaaatactct cgggaacatg
    18121 gcaggcaata tcctgaccaa acttcaaaag ctctcgaaca cctgatgaac tgatatagag
    18181 atgttcaggc cggctatgta aataaatagt ctctatatca gaagacagct gatgattgta
    18241 gtaatcaaaa ctagcttcat attgcaaatc cgccgcattc ctcaaccccc gtactagaaa
    18301 agtagccccc agtctttttg caacatcgac caccaattta tcatgagaag ccacgacttc
    18361 aacattttcc aaatgtccca aagccttttc tagcccccgt ttacgatttt caagagggag
    18421 aaatccttgt ttgtggggat taaaaaaaat acccacataa agcttatcaa aaagtctgct
    18481 cgcccgttca atgatatcca gatgcccatt tgtcatcgga tcaaatgagc ctgtgaataa
    18541 gccaatctta tctgacatag actgtcacct tactaattcc ataaatcttt tccttccaga
    18601 tacccagaca ggcaatttct tctggaagtt caacggcttt atccgtctcg cacacaacca
    18661 taacatcttc agaaaaaagc tctctctcag ccattttttc aatatctgct acgatttgtt
    18721 ccttggcata gggagggtct aagaaaacga ggtcaaattc cccagatacc tgttccaatg
    18781 ccctttctgc atccatcttt aggagttgaa attttccaac ttccttggtc atctggatat
    18841 tttcagccac gatggtctga gccttacggt ctcgctccac caaaacagca ctggacatgc
    18901 cacgcgatac tgcttcgata gataaaccac cactacctgc ataaaggtcc aagactcgtc
    18961 ccacttcaaa gtagggacca atcatgttaa aaatggctcc cctaacctta tccgaagtag
    19021 gtcttgtcgt cttgccttct agtgtcttga ggggacgtcc cccatagatt cctgatacga
    19081 ttttcatact gtttattata ccaaattata gacaaaaaga gaaagaaaac cgaaccttgc
    19141 ggttcgattc tctacaaaat attttcgtaa gtatcgcgga cttcttgagg ccaaacactt
    19201 gtttgcactt ctccgatgtg tctcttgcga agtaggaaca tggccatacg agattgtcca
    19261 attcctccac cgattgtcaa tgggaataga ccattcaaca aagacttgtg ccattccaat
    19321 tccaagcggt cttcatcacc tgtaatttcc acctgacgtc taagagtttc ttcatctaca
    19381 cgaattccca tagaagacaa ctcaaaggct ccacctaaag actcattcca gacaagaata
    19441 tcaccattta gacccttgta gccattctca gactcgcttg tccagtcatc atagtctggt
    19501 gcacgtccat cgtgcggttt accatctggc aactcgccac cgataccaat caaaaagacg
    19561 gctccaaatt ctttacaaat cgcattttca cgttctttcg gtgtcaagtc tgggtagcgt
    19621 tctaccaatt cttctgtatg gataaaggtg atttgttttg gcaagataga ctcgatgtca
    19681 tagcgggctt caacagctag ctcagtcagg cgaatagcct tataaatctt ctcaactgtt
    19741 tcttttagat aaacgatgtt acgcttacca tttgggataa ccttctccca gtcccactgg
    19801 tcaacataaa cagagtgggt tgcatccaag gaatcctcat ctggacgaag ggctttcatg
    19861 tggacaaaga gaccctctcc ttcaccaaag ccaaaacgag ccaaggtgtg gcgtttccat
    19921 ttagcaagtg agtgcaccac ttcataagta gcatcaggga tttggagaac cttgaccgat
    19981 actggatttt ccacaccaga caggttgtcc tgcattccgt caccgacctt actcaagata
    20041 ggaccttgaa cttcgacaac ttctagctta tctttcaaat actgggtaaa agtgtttttg
    20101 acaaaggaaa tttcttcttg ttgatggata aaacttttct tcatagacaa ctcctcaaaa
    20161 atttaataaa cgtattatac acctatttcc aagaaaagaa aagagaaaat ttaaaaaaaa
    20221 tcagtgtcac tcaaaacact gatttcatag accttttagt cattgcgacc aaagatacgt
    20281 agaatactta ggaaaagatt gataaaatca agatagatgc tgagagccat tgacaccacc
    20341 cagcctgtcg ctacacgacc ttgtgattgt tcataggcga ggcgaatctt ttggttatcc
    20401 caagcaatca accctgaaaa aaccaaaacc atggctacgc taatcatata atcaaagaag
    20461 ccactagcca agaaaatatt gactaccata gcaatcagta aaccaatgag agctgccatc
    20521 attgctcgac caatcccact caagtctttc ttggtaaaga taccaactgc cgccatgaca
    20581 aagaagagaa gggcgctcga tacaaaggca gataaaactg tacccggagt atagaaagcc
    20641 accacaaaac taagggtaaa gccgtttaaa acggagtaaa gtaaaaatac tggaagagca
    20701 gctggactat ttcttgaagc catgctactg gcaacgaaaa ccaaagccaa ctccgcaaaa
    20761 gtagcaatgg tcaaccagag acgcccctgc atcaaaaagt aaaccaactg agactgaaaa
    20821 accgtcaaca taaggcctga taccaaagca gatagtccga ttcccagacc aacaaaggca
    20881 taaaccttag cgtaaaattg attgagacct gcacggtcat gtataatagt gtgattcatc
    20941 catttctcct tttctgtgaa catctttcct tgattataac aaaaaaagtt aaaattagct
    21001 taaatagaag attaaaatac cggctgcaac cgcaacattc aaactctcgg cctgcccctt
    21061 catgctaata tggaccaact ggtctgcact ttcagccata aggggactaa ttccttgacc
    21121 ctcatttccc ataactagta caaaattttc tatagaaggc agttctctgt aatcaacaga
    21181 atctttagat agggttgttg ctagcactgg gatagctacc tttttagttt cgtcaagaag
    21241 cgcttgacta gtcatccggt aaatgggcag atggaaatga ctaccttgca tggaacgtag
    21301 ggttttgaga ctgtagatgt ctgccgactt atctgaaaca atcactcctg taaaacctgc
    21361 tgcatccgca gttcgaatga tagttcctac attaccagga tcttgcacat cttccaaaaa
    21421 caagaacttg ccctgactca aatcagcttg tcctacttct tctttttgaa ccacggcaac
    21481 aattccctgt ggagtctgag aatccgccaa atctagcaaa atatcctctg aaatccagac
    21541 agtttgcgga aaagcagcta actgatttcg ataattttct agggcaaaga ttttctcaat
    21601 cgtcactcca gcttggacag cttcttcaaa caagtgccag ccttcaatca aataggcaga
    21661 cttgcggtat tttttttggt gtaatttctt ggcatttttt accacagaat tggcttttga
    21721 ggttataata gtcatagaaa tattataaca caatcaaagg ggtttggtat gcaaaaggtt
    21781 agaatgattg cccaaggtag ggtacaggga gtcggctttc gttggggtgt ttacagcttg
    21841 gcacttgaaa ttggtggcat cacaggtcga gtatggaata acgacgatgg cacagtggaa
    21901 atcttagccc aagcagactc atctgctatc atggcaaaat ttatccaaga aatccgaaaa
    21961 ggaccgacac ctttttcaaa agtaagctac ttagatgtca aactaagcaa ctttcctccc
    22021 tactatgact ttaaaatcgc aaattaggtc tccagaacta ttgtatattt tgtaaaaaaa
    22081 cagtagaata gaaaggtata atttttaaag aaggaataaa aacagtgaaa tctattaaac
    22141 gttttgcact ctcggctatg ggagtggcta tgttgcttgt cttgactggc tgtgtcaatg
    22201 tcgataaaac cacaggtcag ccaacaggat ttatttggaa tacgatcgga gcgcctatgg
    22261 ctgaagctat caagtacttc gctactgata aaggtctagg ctttggtgtc gctatcatca
    22321 tcgtaaccat tatcgtgcgc ttgattatct tgccacttgg tatctaccaa tcatggaagg
    22381 caacgcttca ctctgaaaag atgaacgctc tcaagcatgt ccttgagcca caccaaacac
    22441 gtctcaaaga agcaactact caagaagaaa aactcgaagc ccaacaagcc ctctttgccg
    22501 ctcaaaaaga gcacggcatc agcatgtttg gcggtgtagg atgtttccct atcctccttc
    22561 aaatgccttt cttctctgct atctactttg ctgcccaaca tactgaaggg gttgctcaag
    22621 caagctacct aggcattcct ctaggttctc caagtatgat tttggttgcc tgtgctggtg
    22681 tcctttacta tcttcaatcg ctcctttcac ttcacggagt agaagatgaa atgcaaagag
    22741 aacaaatcaa gaaaatgatt tacatgagcc cactcatgat cgtcgtcttc tccctcttct
    22801 caccagctag tgtcacactt tactgggttg tcggtggttt catgatgatt ctccaacagt
    22861 ttatcgtcaa ctatatcgtt cgtccaaaac ttcgcaaaaa agtccgtgaa gaactagcca
    22921 agaacccacc aaaagcaagt gctttctcta aaccaagtgg acgaaaagac gttacccctg
    22981 aacaaccaac tgctatcaca agcaagaaaa aacacaaaaa tcgcaacgct ggaaaacaac
    23041 gttcgagata agaagaaaaa ggcttagcta gtttgctaag tcttttttgc aagtcatact
    23101 cttcgaaaat caaattcaaa ccacgtcagc ttcgccttgc cgtactcaag tacagcctgc
    23161 ggctagcttc ctagtttgct ctttgatttt cattgagtat caaaagcccg atgtttccat
    23221 caggcttctt ttctatccat gtacacgttt catataatct tgataacttt cggtatccat
    23281 gagtttttta gcgttcttga cgcgatctgc tgttggtggt ttgactcctt cgagggaata
    23341 tggaattcca agttcacgcc acttgaactc acccatggtg tgataaggta gaatttcaaa
    23401 cttatcaaca tttttgaggg tcttgacgaa cttaccaagt tcaatcaagt catcatctct
    23461 gtctgtcaat cctggaacta gcacgtggcg aatccagaca ggttttccaa tatctgatag
    23521 atactgggca caagccaaga tatttttatt agtttggcta gtgacaatct tgtgctgttc
    23581 ttcgttgatt tccttgatat ccaaaagaac caagtcagtg acagccatga gtttgtcaaa
    23641 cttctcaagg taacgtggtt tattacggaa aggaagagca caggtatcca aggtacagtg
    23701 gattccttgt tccttagcct tggtgaagag agcaatcagg aaatcaatct gcaagagagc
    23761 ttctcctcca ctgactgtaa tcccaccctt atttccccag aaaccacggt agcgcaaggc
    23821 ctctgtcaag acatcatcta ccgtccgttc acgtgactta ttggactcca tagcccaagt
    23881 gtctgggttg tggcaatact ggcaacgcat gtgacagccc tgcaaaaaga caataaagcg
    23941 aataccaggc ccatctactg acccaaagct ttctgtcgaa tgcaccattc ctgtcacttg
    24001 tccataatca attgtttctt cagacatatc gttaccttcc ttgaaaacgt tttatagttt
    24061 tattatatca cgacttgaag gaaaaacaag atttttgcct attttttaga aagcaatctg
    24121 tttttcaatt tcattttcaa tctattatca gattattctt caaaatcgaa gccatataag
    24181 gttgcaaaat agtcctcagg gcgctctgca cggcggattt gacgggcttt accttcttcg
    24241 gtatagagga tttccgcaga acgtaatttg gcattatact ggtagcccat tgaaaatccg
    24301 tgggcacctg tatcatgaat taccagcaaa tcaccgattt ctgtatgagg cagttcgcga
    24361 ttgactgcaa atttatcatt gttttcacag agtgaaccaa ccacatctac cgcttcagct
    24421 ggtccatctg gatgggtcac gttgctaata tgatggtaag ctccgtacat agctggacgc
    24481 atgaggttga ctgctgaggc atccacacct agataggtac ggtaggtttc cttcttatga
    24541 gtcactcttg tgactagagc accgtgaggt gccagcataa aacgacccaa ttcggtgaaa
    24601 atcttgacct gaccaagacc tgctggcgta aggacctctt catacacctt acgaactccc
    24661 tcaccaatca aggcgatatc gttcggctcc tggtctggac gataattaac accaataccg
    24721 ccagaaagat tgataaagtc tagccaaatg cccaactttt ccttgatttc aacagccagt
    24781 tcaaagagct gacgagccaa ctctggataa tagagatggg tcacggtatt ggacgctagg
    24841 aaggagtgaa gcccaaaagt cttggctcct ttttccttca agatagcaaa ggcttcaaag
    24901 agctggtcct tggtcatgcc aaacttagcc tccccaggat tatccataat gtctgtcccc
    24961 agttcaaaaa cgcctccagg attataacga caagagatga tttctggaat gcctgctact
    25021 ctctccagat gttcaatatc ttcaaaggca tccaagttaa tggtcgcacc caattcacgt
    25081 gcataggcgt attccttgtc tggcgtgttg ttggaagaga acataatctc agaacccaga
    25141 aagtccagtt tatggctcat caaaagctct acataactag agcagtccac accacaacct
    25201 tcttcttgga gaattttcaa aatagctgga gttggagtag ccttaactgc aaaatattcc
    25261 ttaaagccct tgttccacga aaaagcttgg ttgacggctc ttgccttctc acgaatcccc
    25321 ttctcatcat acaagtgaaa gggagtcggg aactcggcaa caatcgcttc taactcttct
    25381 ctattgataa atggtgtttt cataagcttc cttctattct gtttgcaaag aaaggctggg
    25441 acaatcgttc caacctttag ttctatctct tatttatctt cgtcaaagat attgccaacc
    25501 tcaacatcga tggcttggtt cttgacatca atattggtta ccttcaagag tgacttgtag
    25561 tcaaactgct tttcacgttc ttcttgggca ttgtccgcaa agaccgctac acctgccagt
    25621 tctgagtcga actcgcgcaa gagactaatc ataccattga ccgttccgcc acctttcaag
    25681 aagtcatcca caatcaagac acggctgcct gccttaagac tacgttttga aaggaacatt
    25741 ttctcgatac ggtcaccact tgaacctgaa acatagttga cgctaacagt tgaaccttcg
    25801 gtaattttca ggtcacggcg cacaatgaca aaagagacat tgaggacatt ggcaactgca
    25861 tttgcaagtg gcacaccctt agttgctacg gtcataaccg cgtcaatttt ttggtccata
    25921 aagcttttgg caataatacg accaatattt ttcaagatgg ctggtgtgct aagcaaatca
    25981 gacagataga tataaccacc tggcaagata cggtcacttt ctgacaactt ggtacgcaag
    26041 tcttcaacca tttccttagc atcctgactc gaaatagacg gtgtgaagat gacacctccg
    26101 ccagccccag tcactgtctg gatatgaccg atttcaattt cctcaaaggc gcgtttgata
    26161 atgacgatat cttctgagat ggatgattta gcagactcat acttttcagc aaaagtattg
    26221 agactagtta gtttataagg attattaatc aaatagttgg aaatgacaac catccgatca
    26281 cttcttctta atttcatttc tatttcctat tccattttta ttcaaaaaat caaaaagcaa
    26341 actagaaagc tggtcgctgg tggttcaaaa cactgttttg agattgtcaa tagaactgac
    26401 aaaccctgta atatacctgc atatatacat acgacaaggc gatactaccc tagtttgaag
    26461 agattttcga agagtattca tttttgtctt ttacttatta taccatattc acataaaaaa
    26521 acgaacattc ttatcctaaa aaatgctcat ttttcttaaa ttattaatct aaatctggtt
    26581 tatagaagga acgattatcc atagcgaaga ttttattggt catctctcct ttatccacca
    26641 aagcaagagc tgttgacatc atcatcatgc ttgcatccag attgtcaatc atatggataa
    26701 tctctgcttc cataatgcgt ggacggactg ggcttccata ctcaagcaag ccgtggtgac
    26761 tgaggatgac atgacgaagc aaaacgactt cttccttggt atcatcgatg ccgagttcca
    26821 taactgtctt ggtaatttcg ctatcaatga gagcgatatg tccaagaaga ttacctcgca
    26881 ctgtgtactc tgtctggtct ggccccgtca actcgataac cttagctaag tcatgcagca
    26941 taatccccgc atagagtaag ctcttattga gctgaggata aacttcgcta atagcgtctg
    27001 ccaaacgtac catggtcgcc gtatgataag ccaagcccgt ttcaaaggca tggtggttgg
    27061 tcttggcagc tggataggag tagaattcct tatcatactt ggtgtagaga tttcggacaa
    27121 tccgttgcca gacaggattt tcaattttga aaatcatttg cgacatgtag tcacgaattt
    27181 ccttgacatc aactggtgac ttgaccttga aatcggctgg gtcattgggt tcaccagctt
    27241 gaggcaggcg gagagtaatt tgattgactt gaggggtatt gttataaact tctcggcgtc
    27301 ctttcatgtg gacaacctta cctgcggtaa aggcctcaat gttatgaggt tgggcatccc
    27361 agagcttccc atcaatctcg ccactatcat cttggaaggt aaaggctagg tagtttttcc
    27421 cagctcgagt ttgcctcagg tcagctgatt tgattaggta aaagccttca aatagctcat
    27481 cttttttcat gtgactaatc ttcatattct tcctcatttt cttgaaaatg gagtagatca
    27541 agcgcaggct cgccttctga caactcaatg tgacggagcg tccgctcgat agctatggta
    27601 cgacggttta ataattcatc aatattgcca gaggcatgtt ggagatgttt ttgtgccttg
    27661 accagaatac caccaaactt gccaaactcg gtcttgacac tggcaagagt cttgctgata
    27721 tggtcggcac tcttttggat attaagggtc ttgaaaccaa ctgataggga gttaagaagg
    27781 gctgataggg tacttggtcc tgcaacaata atctgttctt cccgtctcaa atcatcaaag
    27841 aagaccggat tgcgcacaat ctctgaataa agaccttctg tcggaacaaa caagattcca
    27901 aagttggttg tccgaggcgg tgctatgtac ttgctcttga tatccttggc aaagcgcttg
    27961 acgcttgcta ggagtgactt acgacagcgt tcaatctcat ccttgtcacc tgtctcatag
    28021 gcttcttcca agcggtaata atctgccagt ggaaacttag agtcaattgg cagatagacg
    28081 tattcttggt cgccttgtcc gggtaacttg atggcatact ccactcgttc actagagttt
    28141 tcaaccgttg cgtattctcg ttcgtactgg gcaggtgtca tgatgtcttc aataatttgc
    28201 cccagttgca attctcccag aatccctcgc gtcttggttc cagagagaac cttgttaaga
    28261 gctccgacat cacgggcaac tgtctgcatt tctccaaggc cacgattgac agactccagt
    28321 tgtttagaaa ctgtctcaaa ggaagcctgt aagcgtgtct gcaaggtctt ttctagtttt
    28381 tcctcgaccg tctggcgcat ttgttccaaa cgttgctcat ttgattcctg caaggcttgg
    28441 agacgttggt ctgtcttgtc tctagtttgg aggagattat ctgtcatttc ttgacggact
    28501 tgggtcagac cttggtgcaa ttcaatccgc acttcttgca aacggtcgct gacaaccact
    28561 tccaaatctt tttggtctaa ctggctggct tgtctggctt ggtcaaagcg gtaatccaac
    28621 tggtctgaca aatgatctgc ctgatcctcc aagctcttac ttaagtgttt ctcctgccta
    28681 tcctgccttt gccaaatcag aaaaagacca gctaggttgg caattaataa tagaataagt
    28741 aaactttcca tcctacctcc tgtccttgct atgcagtacg accacataac catctgggca
    28801 agttaccgac acttccctat ctatatattc gttagaagcg tacacttttt taaagaaaaa
    28861 attctcctct gtcaactcat acttggctcc aagaatagtc agctggctat cccgaactgg
    28921 cataaaggct agatagtcgt agtctgaacg aggttctagc tgactggtcc cttctgaaca
    28981 ataggcaatc aaattttgcc catcctcaat ttctatttga cgcatatagg gtgccaactt
    29041 aggattgcta ggtagaaaga cattggccaa catatggtca atacggccac ccaaggcacc
    29101 gaaaatagtg acctcagcct gaggattttg ttcaaagatg gttaagagag ccaattccag
    29161 atctgtatca tccttttctg gtcgtgcttg gacaaaatac tgggcacgtt tttgaatcac
    29221 ctgtcgctct tcttccgtca cagaatcaaa atctccgact gctagagcaa gaggtaagtc
    29281 ttcttccaag acccagagcg agcctcgatc caccccaaca aaagcatcaa aatctgtccg
    29341 ataatgaccg cggtttccgc ctgcaaaaac tgcaacccta gtccagttgt tttctgagag
    29401 tttgtactcg ctcattgact tctcccttaa agacatagga acctgctaca aaaacagtcg
    29461 caccagcttc tttggcttgg gcaatagttt ggtcatcaat cccaccatcc acttcgattt
    29521 caaagttcaa acctttttcc tcacgaagag caaccaactc acgaacctta tccatggttt
    29581 ctggcagaaa ggcttgccca ccaaaacctg gattaaccgt catgactaaa acttggtcaa
    29641 ctagatgaag gacgtgcttg atggcttcaa ctggtgtgcc aggattgata acgactgaag
    29701 gcttaactcc gagtgaacga attttttgga gggcgccatg aatatgaggt gttgcttcta
    29761 catggatact gatgatgtct gcacctgcac gcgcaaaatc ttccagatga tgctcagggt
    29821 ttgacaccat caagtggcaa tcgaaaacca tcttactatg aggacgaagg ctctcgacca
    29881 cacctgcacc aaaactgatt tgcggtacaa aatgactgtc catgatatcg atatgggcat
    29941 attctgcccc agttgcttct agacgtttga tttcacgttc aaagttggca taatctgctg
    30001 ccagaattga cggagcaatc ttgtattgag acataggttt ctccttattt tggaattttt
    30061 ttgctgactt ttttataggt ttctctacga ttttcaattt cgctgaggaa ttgcaggtag
    30121 ttgtcaaaac ggaaggtggc aatggtcccc tcttctacag ctggcttgac ggcacaagac
    30181 ggctcatggg tatgggtaca agtacgaaac ttacaatctc ggctgacagt agcaatctct
    30241 gggaaagcct gattgaggtc ttcagccctt gatacttcat agtccagaga tgaaaagcct
    30301 ggtgtgtctg cgattttacc cccgttgaga ttgtaaaaac taacagctcg agtggtatgg
    30361 cgaccgcgac ctagactgtc tgaaatttct cccgtttcaa gattgaggtc tggtacgagt
    30421 ttattgagaa gagttgactt cccaacacct gtctgcccca taaagaccgt aaccttgcct
    30481 gttaacaaag acaggagttc ctctttactg gtcacaaagt catagccgat gtcaccatag
    30541 gtctgccggt aaaaatccag ttctccccta tcttccaaca aatccatttt ggaaatatag
    30601 acaatgggat ggatgccctt gtgctccaaa agaaccaaga aacgatccag caaattgctg
    30661 ttaaaatcag gttccttgac ggacatgatt actacagctt gatcgatatt gacaataggc
    30721 ggacgaacca gactgttttt ccgttcgtga attttgagga tatagccttc tgaattttcc
    30781 tcggcagaga aatctaccca gtccccaaca taaggggtat ggcctttttt acggaaattc
    30841 ccacgcgcgc gtgtttgata aacctggcca tcactctcca catagtagaa acctgccaag
    30901 gctttaatga tttgtccctg catcttagag tccttgccct ttaagtgcgt ctgctagacc
    30961 ggcaaattct gccaagctga gagcttcccc acgcacactt ggtgacaagc ctgcctggtc
    31021 caaagccttg gtcagcttgt ccttgacctc ttcagtctta ccaaagtaac ctgtcaagtt
    31081 attccacaag gtcttgcggc gatgggtaaa actagccttg gaaaccttaa agaaaaagtt
    31141 ctcatcttct actgctacgg ctggctctgg acgacgcacc attttcaaga tggctgaatc
    31201 cacatttggc gctggcacaa agaccgtacg aggcacgata aaggcaacct tggctgtcat
    31261 gtaatactgc acggcgatag acaagctacc gtaagccttg gtgttaggct gggctgaaat
    31321 gcggtccgct acttctttct gcatcatgac cacaaactca caaaaaggaa tgccactctc
    31381 aatcaagtgc atgagaatag gcgtcgtgat gtagtaaggc aaattagcca ctaccttgat
    31441 tggcaggtca ggatttttaa aattctggat atgttgcgcc aaatcaacct tgagaatatc
    31501 ttcgttaact acggtcacat tatcaaaatc acgcagggta tctgccaaaa ttggcaccaa
    31561 acggtggtca atctcaaaag ccatgacttg ggctgcacgc tcagccaaaa attctgtcaa
    31621 ggcaccaata cctggcccga tttcgatgac attgacctga tcatcaattt cagccgtatc
    31681 cacaattttt tgaaggatat tggtatccgt caaaaaattt tgcccaaagg actttttaaa
    31741 ggtaaaaccg tgacgctcca gcactgcctt ggtcacgcta taatctgcaa ttctcatcta
    31801 ttctcttttc tattatctgt tactactatt gtaacacatt ccccttgtat tttgggaatg
    31861 aaaatcatac caaaaaacta tctttcctca tgaagaaaga tagtcttgga aatctttaaa
    31921 agtggcctta gcagttctct cgaaacatgc gttcaaaaaa atcagcttct tgataacttc
    31981 gattttcagg tagggtcaaa tccacatcct cctccacatc atccactgtc agttcaaccg
    32041 tctgaggtaa atttttcaaa cgataatgct tttgcctttg cccttcaata ctagcaaaat
    32101 caagcaaata gccatgcact cggatttgaa ccaaaaggag atgattggtc atattttcca
    32161 tgatgaggat atcttctaaa ccacctctgg cactaggata atcagatacc ctgcgaatac
    32221 ggattttttc acacatgagc aagtttcctc atatcaatga tttcatcagc cttattccag
    32281 actaggggat tatgggtcgc aatgatgata attcgatttt catctttcaa atccaccaag
    32341 agattcataa cctcctctga attttcagga tcaagagctg ctgttggttc atctgccaaa
    32401 atcaagggtg gatttttcaa aatagtctta gcaagggcaa ctcgttgggc ctctccccca
    32461 gataaagtat agattttttg ttctaaatcc aaatacccta gattaacttt ttctaaagcc
    32521 cccacttgcc tttccaaacg ttctactttt gagattttct gaccaacaaa acccaaatcc
    32581 aaattttctt tgattgattg gttttctaag aggccaaaat tttgaaagag atagcccatc
    32641 tgatctcgaa aatactcacg agtgggaatg gtttttaaat ctttcccctg atagagaacc
    32701 cttcctccat ctatcttttc tagctttccc aagatattca gcagcgtcgt ctttccgctt
    32761 ccactctttc cgattaaggc ataaaccttg cccttctcca gcttgagatt caaaccagag
    32821 aaaatcgcgc ggtcattaaa tttcttttcc aatccttgaa tatcaatcat cttattttcc
    32881 tttcaatact gccatgctac cagcttcttc ttttttgtcc tgccttacta aaatcaagag
    32941 ggcgttaagc gtaaacaaag ctacaactag agcgctaatc aaaccatctc ttgtcaaaat
    33001 actagatagg actaggccaa gcaagagaac tcctccttgc gccagtaaat acttgccatg
    33061 aagctcatag attgtcatac cagcaagacg tttaatcata agctcccgtc tgaactgctc
    33121 aaaatagaga agattcatgg aatcaaataa caagatagcc gtagacaggg tcaaaatcgt
    33181 cccaataagg agagagtaaa actccacccg tttgtcattt agtaccttgg caaaaaatag
    33241 ctggcttttt accaagtaag aaaccttgtg atacagacct tgctctttta gagctgtgat
    33301 gctgtctcca tatcgatcta gtttcaaggc actattagcc gtagttcccc acaacatccc
    33361 tgcaacaggt cttgttccag tcgcttgcgg cgttagaact acaataatcg gatcttttag
    33421 gtactggcgt gttgtcttgt acccatcatt atagaggaaa cgttcctgtc ctgtttctgt
    33481 aaaagctagc cttacctgtg ggaagtagtg tttctgactc gtcacttcta cactttcaga
    33541 tgaaaagttt tgcaggtaat ctgtaaacaa tccttggtag taggcagact gctcccgcaa
    33601 gctctcaggc aagatcagcc caaactctcc ctcagacaag ttttgcatct tgtcaataaa
    33661 ctctgaagaa acggtaatct tttcttctat cagatagcgc ggcgagacat agataacatt
    33721 ccctgacggt gtgtagtcac tgagacgatt gccatctagg tccacttctg ctccatctga
    33781 gaaattgtca acattgctca taatataaaa agagtctgta ttggctaacc gttcttcagt
    33841 aaatgtctgc cactcacgat tatccttacg cgttccttct tcatcggcaa atgcactaga
    33901 ccaaccaaag gatagacggt aacggtctga ggactggctc catttattgc tagctctctc
    33961 catttcctgc atttcacggt agtggggtag gagagctgtc gcactcgatc cgaccaccaa
    34021 tacagctaag agttgcccca ccatcatcaa tgtcatcatc cgtttgagag ggagtttccc
    34081 tttcaataga tccaccagac tattttcctg taaaccaagt agatagacga cacttagtaa
    34141 ggtagaaatc cctgccaggg tcaatccata aagtagaaga gcaatgatga ccagttgcac
    34201 cgttgccata aacaaggcac cttgatacca gagaatcccc aatcccaaaa gactggatac
    34261 cagcactgag cagataagct gtctcacatc ttctaacact ggtctgagag caactccaaa
    34321 caagctctca ccagctatta agcgaatccc tgcctgacga agggatttga tccgataaat
    34381 cagggtcaga ctcataaagg tcagcagaaa aatagctaaa ctcagtagca ccataggggt
    34441 ggccgtcaat agtaagacta tcgaaaatgg atcttctcca ttcgaaacaa agccttgata
    34501 accaagctct ttcaaggtgg tctgtaagct cactccatcc aaacttcctg acacaatcaa
    34561 gtaagaccct aataaatcac tcgtttctgc actctccttg gaggaaatgg tcagaccttc
    34621 tggaagcttt ccctcaccat aagtggcata ggtaaagcgt gtttctccag cttcatttgg
    34681 ctcaacaatc cgacgggcga tgagactatt atgctctacc gccaagtgac tcaaagcctc
    34741 tgtcacctct tcgcggctag ctactggttg atttatcatc attcctgtca catcaacaga
    34801 aggatagtta ccaaataaaa tctcttctcg atggtcaacg gaagttatca ccatataaag
    34861 cgataccaat accattgaaa tcaaaataaa taaacgtttc atcatttcct ccaaaaagtt
    34921 acttggtcac ttagtgagaa ggtgaccaag taaagctaaa caatagggct ataccattct
    34981 aaacattata gtagaatgca actttctctc cccaagaagt acgaatccat gcacgagaag
    35041 tccctccagc accagcatat cccttgtcag atgaaccagt ttttctgcta acaactgttg
    35101 aactatggta ttttgaaggg tgatagtagt ttgagtaagc accaccgtta cctgaaccat
    35161 aagtccaaac accaccttct gggtattgaa cggctgcaga ggcaactgat acacctccac
    35221 ctaatgttgc tgcaatgctc gctacaagag ctaacttttt aactgtttgt ttcatattga
    35281 tactcctcta tttttgatta caagattgtt gagttacttg ctcctctttc cattatcaac
    35341 gttgatacta ttatattacc aaatgatatt ctaaaattat ttgtttttct ctaaattgtc
    35401 aaaatagcac cctgaaatga acttttatag tcattatact ccatctttat cacactatca
    35461 aggacatcaa tgtccttaaa atctaactat ttcatattat ttttagctta tatctaaaaa
    35521 aacagttcta aagacgaact ttagaactgt tttgatacga ggacaaggac atttttgtca
    35581 ctgattcact atgtttataa atattttttg acatcctctt gccattcctc tgtcaatttc
    35641 tttactagaa attcatctcc aattagcttc gcaaatgttt tagaagactg ataaaatgat
    35701 tcagctaaac taaaatctct ttctactctt aatgcttgct tccacaaaaa cataaataca
    35761 agaggtttct tttgataatc ttgagtttta tccataattt cttgtaaaca cgatagataa
    35821 tcattaaaac aatcagttac tcctaccttt tcaagacaac acattcctga aataagagta
    35881 tctctaatta taaagtaatt ctctatttga gttaccttct tctgttccaa aagaaagagc
    35941 attagctttt cgatttgatt tataaatttg gcaagatctt ttctaatgag catttgataa
    36001 aaaaacaaac gaatcaacaa catatcattt attgaataag cttctttttc tataatctga
    36061 ggcatatgtt cctcaagtat taactctgca tattcaggcc ttctagttct agaagtatcc
    36121 aaacacgcct gcaatacttc acatgctaat tgttcttctt taggaagatt atcaaagtat
    36181 gttttataaa tctcttccaa acacgcttcc ttcttatcgt actcctcttc tttaccatag
    36241 attggttcac gtaaaatctg gtatttcaat tctaaataag cagaaggaag agctgaaaaa
    36301 tccggcataa ggctataaac tggaactcct agccggcgag caatataggc taacttgggc
    36361 aaactcggtt gcgaagctcc actttcaatt cgcgacagtt gacgaactgt cagttcttgc
    36421 tcatctccac aaaaatctgg acgactaatt cctttttcta tccgaatctc tttaattttt
    36481 tgaccaatta acatcagacg cctcctcttc tacctgcttc gaaaaatact gtgaaactta
    36541 aaaaattgta acggctacat ctttcctact cataagattt catagcttct tccacttctg
    36601 ccaaagtaac cccaaacaac tctaggcgtt tgaggagttg cttgccgtta gaatagccga
    36661 ttcggagagt ctctccgaga tattctctac gcttacggct gtctgcccct gctagaaaac
    36721 caaggcgaat caagtcgcta cgactaatgt caaactgact ctcatgttca aattgttctg
    36781 tcacctgagc tagagccgtt ttcaggtctt catagctggc atgctcaatt cccagagaac
    36841 gccccttggt cttggacttg ggaacagctt catctcgctt gagaaaggca tgctgaactg
    36901 ttggaatggc cgtcataatc atgcgccgaa tccgctcccc attaaaatct gggtctgtaa
    36961 agacaatgac tccatgacgt tggtgtagac gctgaatccg ctctatgtcc tggtcattga
    37021 tggcagaacc tcgagtctca taggtctcca catcgaaata acgcttgaga ttgaccgtat
    37081 catcacgacc ttcaaccacg ataacttggg aaattctctc tttcattact tgctgtccaa
    37141 tccaaaaatt cgttctgcat ttgcagtcgt tgctaccgcc agctcttctg tcgtcatacc
    37201 acgcaagtca gcgataaagt cgaccacata gcgagtatag gctgttttat tttcacgacc
    37261 acgcttgggt acaggtgcta agtaaggcgc atctgtttcc accaacatct tgtccaaagg
    37321 taactcttta gctgcttctt ggaggtcagt tgccttcttg aaagtcacca ctcctgagaa
    37381 ggaaatggtc ataccaagat ccacaaactt ctctgcccac tcaagcgtcc ctgaaaatga
    37441 atgcatgata ccaccacgag gaccaacgcc ctcactcttg ataatctcat aggtatcttc
    37501 cagcgcatca cgggtatgga caacaaaagg caaatccaag tccttagata gctgaatctg
    37561 acggcgaaaa acctgctcct gcacctcttt gggcgctgtc atccaatggt agtctaagcc
    37621 aatttcacct aaagccacaa ccttggaatg ttttaactta tccaacaagt aagcctcaac
    37681 ttcctctgta taagtaccag cttctgtagg atgccaacca atagtcgcat agagctgctc
    37741 atactcatct accaacttca aggcatgctc aatcgtcggt ttatcaaaac caacaatatt
    37801 catctgtgtc acacccatct catcagccaa ggcaatttct tctgcctcac gacctgcaaa
    37861 ttcttctaca ttcaagtgtg tatgtgtatc aaaaatcatc tcttctaacc tcgttttcta
    37921 tcttctatta taccaaaaaa gaggaggggc acctaatttt tcggtttccc ctcctctctt
    37981 caatagagag ctattctgct atcttttcta tccgatattg cccatctcct gtcccacagt
    38041 tagagacaga agagattggc tacattgata gaatattcct attcagctaa agtatgtgat
    38101 tatcttgggt tctcactttt ctcacccatc actaggattg ataacttctc aaaatccccc
    38161 ttataatcta actttaagta gagaatagaa ttttctagct gttctatttt ctacgtctag
    38221 tctttcttcc tagcaaagca aaaccacttg ttgccgccgc tagaccaaga ctagcaagtg
    38281 ctgcacttga tgctgaacct gtgttaggta attgtttgcc agcaggtgac tggtaggtaa
    38341 catcttgcat tgttcctgca gttgcttgcg gtgtacttgt tgtcttagga gcagcattag
    38401 gagccactgg tctcttagga actgtaacca tggcaatggc ttgcactcca atcgtttctg
    38461 cttccttcac atcttccata gttttcgtat tttcaatctc tttgagagct gcttgttttt
    38521 ctgcttccac tcttgctaaa agttctgctt tttctttatc agaaagcggt gcgcctttga
    38581 tttcatcctg cttgtccttg gctgcttttt caatggcatt tttagctgat tctttttcag
    38641 tagctaattg cttagaagct tgtgattgag ctgagttttg tgaacctgtg tgagctgatc
    38701 cacccgcctg gctaccaccg ccttcattcg cattagcatc ttagcttcca gtattgcctc
    38761 ccttatctcc acctggtgta ttttctagct tatactctgg tgtagcttct tgagttacag
    38821 attcaccttt cgcagattgt tgaactgtat cttttcctag aatcgtcact actgaaccat
    38881 ctgggaatgt gattgttgct gtaccatctc cagctacatt gattgtcgct ccgtctaatg
    38941 ctgaaccatt tgcttgtaaa atagcaacct taactttttc ttcatctgtt aaatgagtta
    39001 tatcttttac atctactctt tgagcaggtg ctttaacagt tgatttttca gcagtcagtt
    39061 tagtgctatc ttgtgctttt ggatcttgtg ctaccaattg atttcctgga attgtaatag
    39121 ctgaaccatc tttaaagacg attgttgctg taccatctcc acctacttca actttatagt
    39181 aaaataaaat aataacagga caaatcgatc aggacagtca aatcgatttc taacaatgtt
    39241 ttagaaacag aggtgtacta ttctagtttc aatctactgt aacatcgctt ccgaatccat
    39301 ttgcatctac tgaacttttt tacaaaaata aaaatcagta gactcgagtt cctactgatt
    39361 tttgatagaa ttcgtttgga ttatgcagcc aaaactttgc gtcctttacg acgacgagct
    39421 gccaatacgc gacgaccatt tttagttgac atacggttac ggaatccgtg tttgcgcgca
    39481 cgacgaagtt tacttggttg ataagtacgt ttcacgatga atacctcctc atagattttg
    39541 tattcgttta gccggctata aagtgatcag ttactaaaca tactttacta ttctatctga
    39601 ttctttcact tttgtcaata gctctaggca aatgtttcca gctttttcga atgcaagccc
    39661 tatctacgat actgtttcaa gaaacgagtc atcttttctt ggatttgggc taactcatca
    39721 acacgaggaa ggtaaacgat acggaagtgg tctggttcct gccagttaaa gcctcgacca
    39781 tgaaccaaga gaaccttttc ctgcttcaag aaatcaagga caaactgctc atcatcatcg
    39841 atacggtaca tattgcggtc gatttttggg aagatataga gccccgcctt gggtttaacg
    39901 gcagacaaac ctggaatatc ttgaatggca ttatagatga aatttctttg ctcgtagatt
    39961 cgtccaccag gaagaagcaa ttcatcgact gattggtgac cccccaagga agtttgtacg
    40021 acttgttggg ccaaaacgtt agagcaaagg cgcatattgg acagcatatt gagcccttcg
    40081 atatagccct taacatgagt cttagggcca gacaagacca tccaacccac acggaaacct
    40141 gctatgcggt gggattttga cagaccattc atgctgacac agaagacatc tggtgccaag
    40201 ctcgccacag gcgtatgcac atgtccgtcc attaccatgc ggtcatagat ttcatccgca
    40261 aagataatca aatcgttttg acgggcaatc tcaataatct ccagcaagag ttccttagga
    40321 taaagggctc cagttgggtt atttggattg ataaggacaa ttgccttggt attggaagtg
    40381 atttttgact tgatatcgtc aatatctggg taccattcca cagcttcatc acagatatag
    40441 tgaacggcat ttcctccagc taggctgaca gccgccgtcc atagaggata gtctggcatt
    40501 ggcactaaga cctcatcccc attgtccaaa agcccctgca tggacatgac aatcaactca
    40561 ctgacaccat ttccaaggta aatatcatca atatctacgt ttgggaattt cttcagctgg
    40621 caatactgca tgatggcctt acgggctgag aaaatccctt tggagtcaga atagccttca
    40681 ctatcacgcg cattcataat caagtcatga atgacctcgt ctggcgctgt aaagccaaat
    40741 tctgctggat ttcctgtatt cagacgtaaa atcttttctc cattcgctcg catccgcatg
    40801 gcttcttcca atacaggacc acggatatca taagcaacat gctctaactt actagacttg
    40861 ttatattctt tcatcttgtt tcctcaattc atcaggatag taacattata ccactagaaa
    40921 gagaatgcga caagtttact gaaatgtgtt actagtttcg tatagaagaa aaaccttgct
    40981 aaaggcgagg ttaagaacgt agagatagca ggtattttgc aaagacacat cacataccaa
    41041 aagataaacc tagaaaaaag caagcctaga aaggagtcat aaagaagatt aaacatgagg
    41101 aaaagccccc atatcatcaa gtaatcccaa cgcccacttc gttttgcaac tagaaataag
    41161 attagatggt agagtacatg aaaaactaaa aatccaataa aacttggata aagaagcggt
    41221 accagactct ctaattgaca gatcatgatc acttctacca agactgaaac taggataatt
    41281 ccataataaa ggaaatttga tttttgaaaa gagtttttca tcattctccc ttccttcact
    41341 tctttcctgc tatcctttct tttattttat catatattta tatagagttt aagccctaat
    41401 attcttttga aaaatacttt ttttgcttta cttctatagt gaaaaggttt acaattatag
    41461 taagaaaatt tcaggaggtt tcattatggc acaacgttac caaaatatca tggtcgcaat
    41521 cgatggttct aaggaagcgg acttggcttt tgtcaaggga gttcattctg ctctacgaaa
    41581 cgacgctaaa ctcaccatcg cacatgtcat tgacacacgc gctctccaaa gcgtatccac
    41641 ctttgatgct gaagtttacg aagaactcca agtcgacgct gaaagtctga tgaaagagta
    41701 cgaaaaacgt gctaaagatg ctggggtagc agatgttcat atcgtcattg aaatgggaaa
    41761 tccaaagacc ctgctagcac gtactattcc agatgccgag gaagtggacc tcatcctcgt
    41821 tggcgcaact ggtctcaacg cctttgaacg cctcttggtc ggctcttcat ctgaatacat
    41881 actccgccat gctaaggtcg atttgctggt tgtgagagaa caagaaaaaa ccttataatc
    41941 acaaagaaaa ggagccccta gctccttttt gtttacgatt tatttctctc tttatggcgt
    42001 tcgtaagcct tgagctggcg ctgcagttcc tttttaatag caggttctgg agcatatttt
    42061 tcttcccaat tatctggttt taagatttta tgggtcactg gatcaaaatg agccttgcca
    42121 tctggaaaaa ttttccccat attggcctga tggacaatat caaaaatacg ttctgggtcc
    42181 acccccatca agacaaaact gccgtaggtg aagtaaagcg tgtcaatcaa ggcatccact
    42241 tgccctatca aatcttgctg agcaggtgtc ttcttggcta ctttatctgc tgccttatca
    42301 agggcctgat gaagttgcga tacagcttga ccaaaatctt cttcagaagg actggctgct
    42361 cgaacaaact ccaccaattc ttctatttta aaaccagccc tatgggttgc accctctaaa
    42421 tcccaagctc gaggttcttc ttgggttcgt tcatccatca tgtggtggaa ggtcttgacc
    42481 ttattgaaat gatagtcacg gctgacaaag actttttctg aagacaaaac accaaaatgt
    42541 tccaaggcct tgtggattcc atcttgttga ttgctagtgg taatgtgctt ggcagcttcc
    42601 ttgacactgc tactaccatt tcccatagcg accgacatac caacgccagc cagcatttca
    42661 agatcattat ctgagtcacc aaaagccatg acttggttga ggtcaaagcc atattctttc
    42721 ccaactcggc gaatgccttc taatttagaa tttccctgat tgatgacatc cgatgcaaaa
    42781 ggattgctac gtgtcaattt caagtcttca aaatcagctg ccgccttctc agattcttct
    42841 ggtgtcatca gcatcaaaac ttggtagata ggctgattca tcaggtgaag caggtcctct
    42901 tccttttggg gaacaacctt gctgaccatg cgattaaaag actgactcac cgtccgagtt
    42961 aaaacagagg gaacgaagcg actaattcgt tgggaaaaag aacccagacc aaaggacatg
    43021 attttagaac ccaacatggc atccttggtc cctagagcaa tctccgtgcc ctctttttta
    43081 gcatagctaa ttagatggcg caaatgtaac ttggaaatag ggctcgtgaa caagactctg
    43141 tctttactaa agatatactg gccattatag gttaccgcaa aatccagatc caaatcgtcc
    43201 atcaattcct taacaaaaaa aggtcctcgc cctgtcgcta cgccaactag taccccttgt
    43261 tctttgacaa tcttaatcgc atccttagtg gatttcaaaa cactcttgcg attgttgacc
    43321 aaggttccat cgatatcaaa aaaaacagct ttgacttcca tcctatccca atctcccctt
    43381 ttgtgataca atgattatac cacatttcag aaagagtgag taaatcatgc ctaagaaaat
    43441 ccttgtttta catacgggtg gaactatttc catgcaggcc gatgcttctg gcgctgttgt
    43501 gacgagttca gataatccca tgaaccatgt gtccaaccca cttgaaggaa tccaagtcca
    43561 cgccttggac ttttttaacc ttccaagtcc ctatatcaaa cccaaacata tgctggtcct
    43621 ctaccagaaa attaaagagg aagcagataa ctacgatgga gtggtgatca cacacggaac
    43681 cgatacttta gaggaaacag cctatttcct tgataccatg gaagttcccc atatgcctat
    43741 cgttctaaca ggagccatgc gtagctccaa tgagctcggt agtgatggtg tttataatta
    43801 cctaagtgct ttacgagtgg ccagcgatga cagggctgct gacaaaggag ttttggtcgt
    43861 tatgaacgat gaaatccacg ctgccaagta tgtcaccaaa acacatacga ctaatgtcag
    43921 caccttccag actccaacac atggccccct tggtctcatc atgaaacagg aaatcctcta
    43981 cttcaaaaca gctgaacctc gtgttcgctt tgaccttgat cacatacaag gtttagtccc
    44041 tatcatctcg gcttatgctg gtatgacaga tgagctgatt gatatgctgg atttagaaca
    44101 cttggacggt ttgattatcc aagccttcgg agctggtaat attcccaaag aaacggctca
    44161 aaaattagaa agccttctgc aaaaaggaat tccagtcgct ctggtatcac gatgctttaa
    44221 cggtattgcc gagcctgttt atgcatacca gggtgggggc gtacagttgc aaaaagcagg
    44281 cgttttcttt gttaaagaac tcaacgccca aaaagctcgc ttgaaactcc tcatcgccct
    44341 caatgccgga ctaacaggac aggctttgaa agactatatg gaaggctaat actcttcgaa
    44401 aatctctgca aaccacgtca cgtcgcctta ccgtatgtat ggttactgac ttcgtcagtt
    44461 t
//
LOCUS       DAVLHC010000015        42799 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.015, whole genome shotgun sequence.
ACCESSION   DAVLHC010000015 DAVLHC010000000
VERSION     DAVLHC010000015.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 42799)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 42799)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..42799
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.015"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(346..1320)
                     /gene="pta"
                     /locus_tag="VXE25_000875"
     CDS             complement(346..1320)
                     /gene="pta"
                     /locus_tag="VXE25_000875"
                     /EC_number="2.3.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004252952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate acetyltransferase"
                     /protein_id="HEV0771363.1"
                     /translation="MEVFESLKANLVGKNARIVLPEGEEPRILQATKRLVKETEVIPV
                     LLGNPEKIKIYLEIEGIMDGYEVIDPQHYPQFEEMVSALVERRKGKMTEEDVRKVLVE
                     DVNYFGVMLVYLGLVDGMVSGAIHSTASTVRPALQIIKTRPNVTRTSGAFLMVRGTER
                     YLFGDCAININPDAEALAEIAINSAITAKMFGIEPKIAMLSYSTKGSGFGESVDKVVE
                     ATKIAHDLRPDLEIDGELQFDAAFVPETAALKAPGSTVAGQANVFIFPGIEAGNIGYK
                     MAERLGGFAAVGPVLQGLNKPVNDLSRGCNADDVYKLTLITAAQAVHQ"
     gene            complement(1364..2260)
                     /locus_tag="VXE25_000876"
     CDS             complement(1364..2260)
                     /locus_tag="VXE25_000876"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001209987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HEV0771364.1"
                     /translation="MRFEFIADEHVKVKTFLKKHEVSKGLLAKIKFRGGAILVNNQPQ
                     NATYLLDVGDYVTIYIPAEEGFETLEAIELPLDILYEDDHFLVLNKPYGVASIPSVNH
                     SNTIANFIKGYYVKQNYENQQVHIVTRLDRDTSGLMLFAKHGYAHARLDKQLQKKSIE
                     KRYFALVKGDGHLEPEGEIIAPIARDEDSIITRRVAKGGKYAHTSYKIVASYGNIHLV
                     YIHLHTGRTHQIRVHFSHIGFPLLGDDLYGGSLEDGIQRQALHCHYLSFYHPFLEQDL
                     QLESPLPDDFSNLITQLSTNTL"
     gene            complement(2257..3075)
                     /locus_tag="VXE25_000877"
     CDS             complement(2257..3075)
                     /locus_tag="VXE25_000877"
                     /EC_number="2.7.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000799053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD kinase"
                     /protein_id="HEV0771365.1"
                     /translation="MKNTGKRIDLIANRKPQSQRVLYELRDRLKRNQFILNDTNPDIV
                     ISIGGDGMLLSAFHKYENQLDKVRFIGLHTGHLGFYTDYRDFELDKLVTNLQLDTGAR
                     VSYPVLNVKVFLENGEVKIFRALNEASIRRSDRTMVADIVINGVPFERFRGDGLTVST
                     PTGSTAYNKSLGGAVLHPTIEALQLTEIASLNNRVYRTLGSSIIVPKKDKIELIPTRN
                     DYHTISVDNSVYSFRNIERIEYQIDHHKIHFVATPSHTSFWNRVKDAFIGEVDE"
     gene            complement(3059..3730)
                     /locus_tag="VXE25_000878"
     CDS             complement(3059..3730)
                     /locus_tag="VXE25_000878"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000171686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP pyrophosphokinase family protein"
                     /protein_id="HEV0771366.1"
                     /translation="MTLEWEEFLDPYIQAVGELKIKLRGIRKQYRKQNKHSPIEFVTG
                     RVKPIESIKEKMARRGITYATLEHDLQDIAGLRVMVQFVDDVKEVVDILHKRQDMRII
                     QERDYITHRKASGYRSYHVVVEYTVDTINGAKTILAEIQIRTLAMNFWATIEHSLNYK
                     YQGDFPDEIKKRLEITARIAHQLDEEMGEIRDDIQEAQALFDPLSRKLNDGVGNSDDT
                     DEEYR"
     gene            3858..4427
                     /locus_tag="VXE25_000879"
     CDS             3858..4427
                     /locus_tag="VXE25_000879"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000681289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CYTH domain-containing protein"
                     /protein_id="HEV0771367.1"
                     /translation="MKHLEIELKTLLKKDEYNRLKDQFTGVTPVLQTNYYIDTPDFEL
                     REKKVAMRIRTFEDWAELTLKVPQSVGNMEYNQKLQLKDAENYLSKEELPQGLVLDEL
                     AKHGIQSKNWQVLGCLTTLRYEMKTAIGLMALDQSRYFDITDYELELEVENHEQGKQD
                     FRQFLEKNQISYQKAPSKLVRFVKSMKNS"
     gene            4540..5499
                     /locus_tag="VXE25_000880"
     CDS             4540..5499
                     /locus_tag="VXE25_000880"
                     /EC_number="2.7.6.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001280885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-phosphate diphosphokinase"
                     /protein_id="HEV0771368.1"
                     /translation="MSDRKNMKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQ
                     VNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDACVRASAHSINVVLPYFGYARQDR
                     IACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCD
                     KGLLGSDVVVVSPKNSGVKRARSLAEYLDAPIAIIDYPQDDATRNEGYIIGDVEGKKA
                     ILIDDILNTGRTFSEASKIVEREGATEIYAVSSHGLFVEGAAELLDNTNIKEILVTDS
                     VATKEKTPKNVCYITASELIGDAIVRIHERKPVSPLFAYNKKK"
     gene            5509..6624
                     /locus_tag="VXE25_000881"
     CDS             5509..6624
                     /locus_tag="VXE25_000881"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000639661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase"
                     /protein_id="HEV0771369.1"
                     /translation="MIYLDNAATTPMSAVAISAMTKVMQETHGNPSSIHGHGRQAGKL
                     LREARQELAQLLRTKPQHIFFTSGGTEGNNTTIIGYCLRHQEQGKHIITTAIEHHAVL
                     ETIDYLVQHFGFEATIIQPENQEITAQQIQKALRDDTILVSTMFANNETGNLLPIAEI
                     GQILKQHPAAYHVDAVQAIGKIPIHSEELGIDFLTASAHKFHGPKGIGFLYASSMDFD
                     SYLHGGDQEQKKRAGTENLPAIVGMVAALKEDLEKQEEHFQHVQNLETAFLAELEGIQ
                     YYLNRGKHHLPYVLNIGFPGQKNDLLLLRLDLAGISISTGSACTAGVVQSSHVLEAMY
                     GANSERLKESLRISLSPQNTVEDLQTLAKTLKEIIGG"
     gene            6629..6976
                     /locus_tag="VXE25_000882"
     CDS             6629..6976
                     /locus_tag="VXE25_000882"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000863538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1831 domain-containing protein"
                     /protein_id="HEV0771370.1"
                     /translation="MAFEKIIQLKNCRYDYTLSPSVKKFTLKDNTFFETKVGNYELTR
                     LLEKVPNSGEGFQLKIIINKELTGAKINITDKFGLRLVDIFKSEDHHIHQEKFYFLMD
                     SLVERGVFTKSER"
     gene            6984..7199
                     /locus_tag="VXE25_000883"
     CDS             6984..7199
                     /locus_tag="VXE25_000883"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000462494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4649 family protein"
                     /protein_id="HEV0771371.1"
                     /translation="MFELTYKDCYHVERTLKYEDHEALMLTLSGCVTLPDTLYVTSLT
                     FRGKKVYQGLVGDLYRFLSHADFLHQN"
     gene            7282..7923
                     /locus_tag="VXE25_000884"
     CDS             7282..7923
                     /locus_tag="VXE25_000884"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000653420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redox-sensing transcriptional repressor Rex"
                     /protein_id="HEV0771372.1"
                     /translation="MKDKQFAIPKATAKRLSLYYRIFKRFHAEKIERANSKQIAEAIG
                     IDSATVRRDFSYFGELGRRGFGYDVKKLMTFFADLLNDNSITNVMLVGIGNMGHALLH
                     YRFHERNKMKIIMAFDLDDHPEVGTQTPDGIPIYGISQIKDKIKDADVKTAILTVPSV
                     KSQEVANLLVDAGVKGILSFSPVHLHLPKDVVVQYVDLTSELQTLLYFMRKED"
     gene            7941..8630
                     /locus_tag="VXE25_000885"
     CDS             7941..8630
                     /locus_tag="VXE25_000885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamyl-gamma-aminobutyrate hydrolase
                     family protein"
                     /protein_id="HEV0771373.1"
                     /translation="MKKPVIGITGNEKTHPDDDIMMSYAAKGFVEGVKDAGGIPIILP
                     IGDQEMACHYISLIDKLILTGGQNVDPKFYGEPKTIDSDDYHLQRDIFELALIKEAIK
                     QKKPIFSVCRGTQLFNVAMGGTLYQDIEDHWQDSSVEYTTQRLVTEPDTVLQEIYGEI
                     SHINSFHHQSIKDLAPNLKVVAHDPKDGIIEAVMSTDDVAFLGVQWHPELLFENRPKD
                     KKLFDYVVNEL"
     gene            complement(8627..9307)
                     /gene="radC"
                     /locus_tag="VXE25_000886"
     CDS             complement(8627..9307)
                     /gene="radC"
                     /locus_tag="VXE25_000886"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000286923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RadC"
                     /protein_id="HEV0771374.1"
                     /translation="MYSISFQEDSLLPRERLAKEGVEALSNQELLAILLRTGTRQASV
                     FEIAQKVLNNLSSLTDLKKMTLQELQSLSGIGRVKAIELQAMIELGHRIHKHETLEME
                     SILSSQKLAKKMQQELGDKKQEHLVALYLNTQNQIIHQQTIFIGSVTRSIAEPREILH
                     YAIKHMATSLILVHNHPSGAVAPSQNDDHVTKLVKEACELMGIVLLDHLIVSHSNYFS
                     YREKTDLI"
     gene            complement(9350..11641)
                     /gene="pcrA"
                     /locus_tag="VXE25_000887"
     CDS             complement(9350..11641)
                     /gene="pcrA"
                     /locus_tag="VXE25_000887"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000992850.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA helicase PcrA"
                     /protein_id="HEV0771375.1"
                     /translation="MNALLNGMNDRQAEAVQTTEGPLLIMAGAGSGKTRVLTHRIAYL
                     IDEKLVNPWNILAITFTNKAAREMKERAYSLNPATQDCLIATFHSMCVRILRRDADHI
                     GYNRNFTIVDPGEQRTLMKRILKQLNLDPKKWNERTILGTISNAKNDLIDDVAYAAQA
                     GDMYTQIVAQCYTTYQKELRQSESVDFDDLIMLTLRLFDQNPDVLTYYQQKFQYIHVD
                     EYQDTNHAQYQLVKLLASRFKNICVVGDADQSIYGWRGADMQNILDFEKDYPKAKVVL
                     LEENYRSTKTILQAANEVIKNNKNRRPKNLWTQNADGEQIVYYCADDELDEAVFVART
                     IDELSRSQNFLHKDFAVLYRTNAQSRTIEEALLKSNIPYTMVGGTKFYSRKEIRDIIA
                     YLNLIANLSDNISFERIINEPKRGIGPGTVEKIRDFANLQNMSMLDASANIMLSGIKG
                     KAAQSIWDFANMMLDLREQLDHLSITELVESVLEKTGYVDILNAQATLESKARVENIE
                     EFLSVTKNFDDTTDVAEEETGLDKLSRFLNDLALIADTDSGSQETSEVTLMTLHAAKG
                     LEFPVVFLIGMEENVFPLSRATEDPDELEEERRLAYVGITRAEKILYLTNANSRLLFG
                     RTNYNRPTRFINEISSDLLEYQGLARPANTSFKASYSSGSISFGQGMSLAQALQDRKR
                     GAAPKSIQSSGLPFGQFTAGAKSASIEANWSIGDIALHKKWGEGTVLEVSGSGARQEL
                     KINFPEVGLKKLLASVAPIEKKI"
     gene            complement(11833..12638)
                     /locus_tag="VXE25_000888"
                     /pseudo
     CDS             complement(11833..12638)
                     /locus_tag="VXE25_000888"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="programmed frameshift; internal stop; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS5 family transposase"
     gene            complement(13018..13878)
                     /locus_tag="VXE25_000889"
     CDS             complement(13018..13878)
                     /locus_tag="VXE25_000889"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013903404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionyl aminopeptidase"
                     /protein_id="HEV0771376.1"
                     /translation="MITLKSAREIEAMDKAGDFLASIHIGLRDLIKPGVDMWEVEEYV
                     RRRCKEENFLPLQIGVDGAMMDYPYATCCSLNDEVAHAFPRHYILKDGDLLKVDMVLG
                     GPIAKSDLNVSKLNFNNVEQMKKYTQSYSGGLADSCWAYAVGTPSEEVKNLMDVTKEA
                     MYKGIEQAVVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGIAG
                     RGLRLREGMVLTIEPMINTGDWEIDTDMKTGWAHKTIDGGLSCQYEHQFVITKDGPVI
                     LTSQGEEGTY"
     gene            complement(13894..15171)
                     /locus_tag="VXE25_000890"
     CDS             complement(13894..15171)
                     /locus_tag="VXE25_000890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBS domain-containing protein"
                     /protein_id="HEV0771377.1"
                     /translation="MSKHQEILSYLEELPVGKRVSVRSISNHLGVSDGTAYRAIKEAE
                     NRGIVETRPRSGTIRVKSQKVAIDRLTFAEIAEVTSSEVLAGQEGLEREFSKFSIGAM
                     TEQNILSYLHDGGLLIVGDRTRIQLLALENENAVLVTGGFQVHDDVLKLANQKGIPVL
                     RSKHDTFTVATMINKALSNVQIKTDILTVEKLYRPSHEYGFLRETDTVKDYLDLVRKN
                     RSSRFPVINQHQVVVGVVTMRDAGDKSPSTTIDKVMSRSLFLVGLSTNIANVSQRMIA
                     EDFEMVPVVRSNQTLLGVVTRRDVMEKMSRSQVSALPTFSEQIGQKLSYHHDEVVITV
                     EPFMLEKNGVLANGVLAEILTHMTQDLVVNSGRNLIIEQMLIYFLQAVQIDDILRIQA
                     RIIHHTRRSAIIDYDIYHGHQIVSKANVTVKIN"
     gene            complement(15164..15715)
                     /locus_tag="VXE25_000891"
     CDS             complement(15164..15715)
                     /locus_tag="VXE25_000891"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0771378.1"
                     /translation="MNIWTKLAMFSFFETDRLYLRPFFFSDSQDFREIASNPENLQFI
                     FPTQASLEESQYALANYFMKSPLGVWAICDQKNQQMIGSIKFEKLDEIKKEAELGYFL
                     RKDAWSQGFMTEVVRKICQLSFEEFGLKQLFIITHLENEASQRVALKSGFSLFRQFKG
                     SDRYTRKMRDYLEFRYVKGEFNE"
     gene            complement(15731..16990)
                     /locus_tag="VXE25_000892"
     CDS             complement(15731..16990)
                     /locus_tag="VXE25_000892"
                     /EC_number="2.5.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase"
                     /protein_id="HEV0771379.1"
                     /translation="MRKIVINGGLPLQGEITISGAKNSVVALIPAIILADDVVTLDCV
                     PDISDVASLVEIMELMGATVKRYDDVLEIDPRGVQNIPMPYGKINSLRASYYFYGSLL
                     GRFGEATVGLPGGCDLGPRPIDLHLKAFEAMGATASYEGDNMKLSAKDTGLHGASIYM
                     DTVSVGATINTMIAAVKANGRTIIENAAREPEIIDVATLLNNMGAHIRGAGTNIIIID
                     GVERLHGTRHQVIPDRIEAGTYISLAAAVGKGIRINNVLYEHLEGFIAKLEEMGVRMT
                     VSEDSIFVEEQSNLKAINIKTAPYPGFATDLQQPLTPLLLRANGRGTIVDTIYEKRVN
                     HVFELAKMDADISTTNGHILYTGGRDLRGASVKATDLRAGAALVIAGLMAEGKTEITN
                     IEFILRGYSDIIEKLRNLGADIRLVED"
     gene            complement(18039..18197)
                     /locus_tag="VXE25_000893"
     CDS             complement(18039..18197)
                     /locus_tag="VXE25_000893"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001841691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771380.1"
                     /translation="MGDKPISFRDADGNFVSAADVWNEKKLEELFNRLNPNRALRLAR
                     TKKENPSQ"
     gene            complement(18207..19517)
                     /gene="obgE"
                     /locus_tag="VXE25_000894"
     CDS             complement(18207..19517)
                     /gene="obgE"
                     /locus_tag="VXE25_000894"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase ObgE"
                     /protein_id="HEV0771381.1"
                     /translation="MSMFLDTAKIKVKAGNGGDGMVAFRREKYVPNGGPWGGDGGRGG
                     NVVFVVDEGLRTLMDFRYNRHFKADSGEKGMTKGMHGRGAEDLRVLVPQGTTVRDAET
                     GKVLTDLIEHGQEFIVAHGGRGGRGNIRFATPKNPAPEISENGEPGQERELQLELKIL
                     ADVGLVGFPSVGKSTLLSVITSAKPKIGAYHFTTIVPNLGMVRTQSGESFAVADLPGL
                     IEGASQGVGLGTQFLRHIERTRVILHIIDMSASEGRDPYEDYLAINKELESYNLRLME
                     RPQIIVANKMDMPESQENLEEFKKKLAENYDEFEELPAIFPISGLTKQGLVTLLDATA
                     ELLDKTPEFLLYDESDMEEEAYYGFDEEEKAFEISRDDDATWVLSGEKLMKLFNMTNF
                     DRDESVMKFARQLRGMGVDEALRARGAKDGDLVRIGKFEFEFVD"
     gene            complement(19581..19715)
                     /locus_tag="VXE25_000895"
     CDS             complement(19581..19715)
                     /locus_tag="VXE25_000895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000863859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4044 domain-containing protein"
                     /protein_id="HEV0771382.1"
                     /translation="MAFGDNGNRKKTMFEKITLFIVIIMLVASLLGIFATAIGALSNL
                     "
     gene            complement(19774..19950)
                     /locus_tag="VXE25_000896"
     CDS             complement(19774..19950)
                     /locus_tag="VXE25_000896"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PspC domain-containing protein"
                     /protein_id="HEV0771383.1"
                     /translation="MRSGRDKKIAGVCAGVAYYLDMDPTIVRVIWGVLTCCYGAGIVA
                     YIILWIIAPVATDY"
     gene            complement(19981..21306)
                     /locus_tag="VXE25_000897"
     CDS             complement(19981..21306)
                     /locus_tag="VXE25_000897"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="HEV0771384.1"
                     /translation="MRIGLFTDTYFPQVSGVATSIRTLKTELEKQGHAVFIFTTTDKD
                     VNRYEDWQIIRIPSVPFFAFKDRRFAYRGFSKALEIAKQYQLDIIHTQTEFSLGLLGI
                     WIARELKIPVIHTYHTQYEDYVHYIAKGMLIRPSMVKYLVRGFLHDVDGVICPSEIVR
                     DLLSDYKVKVEKRVIPTGIELAKFERPEIKQENLKELRSKLGIQDGEKTLLSLSRISY
                     EKNIQAVLAAFADVLKEEDKVKLVVAGDGPYLNDLKEQAQNLEIQDSVIFTGMIAPSE
                     TALYYKAADFFISASTSETQGLTYLESLASGTPVIAHGNPYLNNLISDKMFGTLYYGE
                     HDLAGAILEALIATPDMNEHTLSEKLYEISAENFGKRVHEFYLDAIISNNFQKDLAKD
                     DTVSQRIFKTVLYLPQQVVAVPVKGSRRMLKASKTQLISMRDYWKDHEE"
     gene            complement(21322..22365)
                     /gene="cpoA"
                     /locus_tag="VXE25_000898"
     CDS             complement(21322..22365)
                     /gene="cpoA"
                     /locus_tag="VXE25_000898"
                     /EC_number="2.4.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-galactosylglucosyldiacylglycerol synthase"
                     /protein_id="HEV0771385.1"
                     /translation="MEKKKLRINMLSSSEKVAGQGVSGAYRELVRLLHRAAKDQLIVT
                     ENLPIEADVTHFHTIDFPYYLSTFQKKRSGRKIGYVHFLPATLEGSLKIPFFLKGIVK
                     RYVFSFYNRMEHLVVVNPMFIEDLVAAGIPREKVTYIPNFVNKEKWHPLPQEEVVRLR
                     TDLGLSDNQFIVVGAGQVQKRKGIDDFIRLAEELPQITFIWAGGFSFGGMTDGYEHYK
                     KIMENPPKNLIFPGIVSPERMRELYALADLFLLPSYNELFPMTILEAASCEAPIMLRD
                     LDLYKVILEGNYRATAGREEMKEAILEYQANPAALKDLKEKAKNISREYSEENLLQIW
                     LDFYEKQAALGRK"
     gene            complement(22480..22809)
                     /locus_tag="VXE25_000899"
     CDS             complement(22480..22809)
                     /locus_tag="VXE25_000899"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331934.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-sulfur cluster assembly factor"
                     /protein_id="HEV0771386.1"
                     /translation="MAYTEEQIENIKTRILTALEEVIDPELGIDIVNLGLIYEIRFDG
                     DTGQTEIDMTLTTMGCPLADLLTDQIYDAMIEVPEVTDTEVKLVWYPAWTVEKMSRYA
                     RIALGIK"
     gene            complement(22823..23932)
                     /gene="rpoD"
                     /locus_tag="VXE25_000900"
     CDS             complement(22823..23932)
                     /gene="rpoD"
                     /locus_tag="VXE25_000900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000201905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sigma factor RpoD"
                     /protein_id="HEV0771387.1"
                     /translation="MATKQKEVTTFDVQVAEFIRNHKQKGTATDDEINASLVIPFTLD
                     ADGIEDLLQRIQDAGISITDNEGNPSARVLSNEEEPELSDEDLIGSTSAKVNDPVRMY
                     LKEIGVVPLLTNEEEKELALAVEAGDIEAKQRLAEANLRLVVSIAKRYVGRGMQFLDL
                     IQEGNMGLMKAVDKFDYSKGFKFSTYATWWIRQAITRAIADQARTIRIPVHMVETINK
                     LVREQRNLLQELGQDPTPEQIAERMDMTPDKVREILKIAQEPVSLETPIGEEDDSHLG
                     DFIEDEVIENPVDYTTRIVLREQLDEILDTLTDREENVLRLRFGLDDGKMRTLEDVGK
                     VFNVTRERIRQIEAKALRKLRQPSRSKPLRDFIED"
     gene            complement(23935..25695)
                     /gene="dnaG"
                     /locus_tag="VXE25_000901"
     CDS             complement(23935..25695)
                     /gene="dnaG"
                     /locus_tag="VXE25_000901"
                     /EC_number="2.7.7.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000227865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA primase"
                     /protein_id="HEV0771388.1"
                     /translation="MVDKQVIEEIKNNANIVEVIGDVISLQKAGRNYLGLCPFHGEKT
                     PSFNVVEDKQFYHCFGCGRSGDVFKFIEEYQGVPFIEAVQILGQRVGIEVEKPLYSEQ
                     KSASPHQDLYDMHEDAAKFYHAILMTTTMGEEARNYLYQRGLTDEVLKHFWIGLAPPE
                     RNYLYQRLSDQYREEDLLDSGLFYLSDANQFVDTFHNRIMFPLTNDQGKVIAFSGRIW
                     QKTDSQTSKYKNSRSTAIFNKSYELYHMDRAKRSSGKASEIYLMEGFMDVIAAYRAGI
                     ENAVASMGTALSREHVEHLKRLTKKLVLVYDGDKAGQAATLKALDEIGDMPAQIVSMP
                     DNLDPDEYLQKNGPEDLAYLLTKTRISPIEFYIHQYKPENSENLQAQIEFIEKIAPLI
                     VQEKSIAAQNSYIHILADSLASFDYTQIEQIVNESRQVQRQNRMERISRPTPITMPVT
                     KQLSAIMRAEAHLLYRMMESPLVLNDYRLREDFAFATPEFQVLYDLLGQYGNLPPEVL
                     AEQTEEVERAWYQVLAQDLPAEISPQELSEVEMTRNKALLNQDNMRIKKKVQEASHVG
                     DTDTALEELERLISQKRRME"
     gene            complement(25785..26543)
                     /locus_tag="VXE25_000902"
     CDS             complement(25785..26543)
                     /locus_tag="VXE25_000902"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000125420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0771389.1"
                     /translation="MTAIVELKNATKIVKNGFDEEKIILNDVSLEIFEQDFITILGGN
                     GAGKSTLFNTIAGTISLTSGTIRILGEDVTKFSPEKRAKYLSRVFQDPKMGTAPRMTV
                     AENLLIAKFRGEKRGLFPRRLASYKDKFQATIEKVGNGLEKHLNTPIEFLSGGQRQAL
                     SLLMATLKRPELLLLDEHTAALDPKTSVALMELTDEFVKKDQLTALMITHHMEDALKY
                     GNRLIVMKEGRIIQDLNQEEKAKMKISDYYQLFE"
     gene            complement(26540..27406)
                     /locus_tag="VXE25_000903"
     CDS             complement(26540..27406)
                     /locus_tag="VXE25_000903"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEV0771390.1"
                     /translation="MIVSIISQGFVWAILGLGIFMTFRILNFPDMTTEGSFPLGGAVA
                     VTLITKGVNPFLATLVAVGAGCLAGMAAGLLYTKGKIPTLLSGILVMTSCHSIMLLIM
                     GRANLGLLGTKQIQDVLPFDSDLNQLLTGLIFVSIVIALMLFFLDTKLGQAYIATGDN
                     PDMARSFGIHTGRMELMGLVLSNGVIALAGALIAQQEGYADVSRGIGVIVVGLASLII
                     GEVIFKSLSLAERLVTIVVGSIAYQFLVWAVIALGFNTSYLRLYSALILAVCLMIPTF
                     KQTILKGAKLSK"
     gene            complement(27475..28479)
                     /locus_tag="VXE25_000904"
     CDS             complement(27475..28479)
                     /locus_tag="VXE25_000904"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HEV0771391.1"
                     /translation="MKNKRLIGIIAALAVLVAGSLIYSSMNKSEVQNNKDEKKITKIG
                     VLQFVSHPSLDLIYKGIQDGLAEEGYKDDQVKIDFMNSEGDQSKVATMSKQLVANGND
                     LVVGIATPAAQGLASATKDLPVIMAAITDPIGANLVKDLKKPGGNVTGVSDHNPAQQQ
                     VELIKALTPNVKTIGALYSSSEDNSKTQVEEFKAYAEKAGLTVETFAVPSTNEIASTV
                     TVMTSKVDAIWVPIDNTIASGFPTVVSSNQSSKKPIYPSATAMVEVGGLASVVIDQHD
                     LGVATGKMIVQVLKGAKPADTPVNVFSTGKSVINKKIAQELGITIPESVLKEAGQVIE
                     "
     misc_binding    complement(28592..28809)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(28892..31588)
                     /gene="ppc"
                     /locus_tag="VXE25_000905"
     CDS             complement(28892..31588)
                     /gene="ppc"
                     /locus_tag="VXE25_000905"
                     /EC_number="4.1.1.31"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000058210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoenolpyruvate carboxylase"
                     /protein_id="HEV0771392.1"
                     /translation="MSLQKLENYSNKSVVQEEVLILTELLEDITKNMLAPETFEKIIQ
                     LKELSTQEDYQGLNRLVTSLSNDEMVYISRYFSILPLLINISEDVDLAYEINHQNNID
                     QDYLGKLSTTIKLVAEKENAVEILEHLNVVPVLTAHPTQVQRKSMLDLTNHIHSLLRK
                     YRDVKLGLINKDKWYNDLRRYIEIIMQTDMIREKKLKVTNEITNAMEYYNSSFLKAVP
                     HLTTEYKRLAQAHGLNLKQAKPITMGMWIGGDRDGNPFVTAKTLKQSALTQCEVIMNY
                     YDKKIYQLYREFSLSTSIVNVSKQVREMARQSKDNSIYREKELYRRALFDIQSKIQAT
                     KTYLIEDEEVGTRYETANDFYKDLIAIRDSLLENKGESLISGDFVELLQAVEIFGFYL
                     ASIDMRQDSSVYEACVAELLKSAGIHSRYSELSEEEKCDLLLKELEEDPRILSATHAE
                     KSELLAKELAIFKTARVLKDKLGDDVIRQTIISHATSLSDMLELAILLKEVGLVDTER
                     ARVQIVPLFETIEDLDHSEETMRKYLSLSLAKKWIDSRNNYQEIMLGYSDSNKDGGYL
                     SSCWTLYKAQQQLTAIGDEFGVKVTFFHGRGGTVGRGGGPTYEAITSQPLKSIKDRIR
                     LTEQGEVIGNKYGNKDAAYYNLEMLVSAAINRMITQKKSDTNTPNRYEAIMDQVVDRS
                     YDIYRDLVFGNEHFYDYFFESSPIKAISSFNIGSRPAARKTITEIGGLRAIPWVFSWS
                     QSRVMFPGWYGVGSSFKEFINKNPENIAILRDMYQNWPFFQSLLSNVDMVLSKSNMNI
                     AFEYAKLCEDEQVKAIYETILNEWQVTKNVILAIEGHDELLADNPYLKASLDYRMPYF
                     NILNYIQLELIKRQRRGELSSDQERLIHITINGIATGLRNSG"
     gene            complement(31608..32837)
                     /locus_tag="VXE25_000906"
     CDS             complement(31608..32837)
                     /locus_tag="VXE25_000906"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsW/RodA/SpoVE family cell cycle protein"
                     /protein_id="HEV0771393.1"
                     /translation="MKISKRHLLNYSILIPYLLLSILGLIVVYSTTSAILIEEGKSAL
                     QLVRNQGIFWIVSLILIALIYKLRLDFLRNERLIILVILIEMLLLFLARFIGLSVNGA
                     YGWISVAGVTIQPAEYLKIIIIWYLAHRFSKQQEEIATYDFQVLTQNQWLPRAFNDWR
                     FVLLVLIGSLGIFPDLGNATILVLVSLIMYTVSGIAYRWFSTILALVSAASVFVLTTI
                     SLIGVETFSKIPVFGYVAKRFSAFFNPFADRADAGHQLANSYFAMVNGGWFGLGLGNS
                     IEKRGYLPEAHTDFVFSIVIEEFGFVGASLILALLFFMILRIILVGIRAENPFNAMVA
                     LGVGGMMLVQVFVNIGGISGLIPSTGVTFPFLSQGGNSLLVLSVAVAFVLNIDASEKR
                     AKLYRELENQPMNLLLK"
     gene            complement(32965..33294)
                     /locus_tag="VXE25_000907"
                     /pseudo
     CDS             complement(32965..33294)
                     /locus_tag="VXE25_000907"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
     gene            complement(33399..33647)
                     /locus_tag="VXE25_000908"
                     /pseudo
     CDS             complement(33399..33647)
                     /locus_tag="VXE25_000908"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000335280.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside phosphotransferase"
     gene            complement(33928..34515)
                     /locus_tag="VXE25_000909"
     CDS             complement(33928..34515)
                     /locus_tag="VXE25_000909"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000509391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Type 1 glutamine amidotransferase-like
                     domain-containing protein"
                     /protein_id="HEV0771394.1"
                     /translation="MGGNPPIKNYTIVNKIVSSRKIERIVIFTVFRENWEPYMKKYTE
                     VFQSQFPNLNIDYLLLDTEQIDLDSYLDADIIIIGGGNTEKYIATYVNQEFKSYIDHM
                     LNKEAKIIGFSAGALLLGEKVYVSPNVNSDYQIKIKNGLGLFSQFLISVHYDSWNDKA
                     NKDRAEELVNVPIIPLNDHSCLVLDKLGNIIEKID"
     gene            complement(34620..36413)
                     /locus_tag="VXE25_000910"
     CDS             complement(34620..36413)
                     /locus_tag="VXE25_000910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864824.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HEV0771395.1"
                     /translation="MKKNNVEIIKADSLVRRRGDNVERHLKRVAAYCRVSSDSEDQKN
                     SYDSQVRHYKEYISQRSDWELADIYADEGISGTQVGKRQDFQRLINDCANGEIDYIVT
                     KAIARFARNTLDTLKYVRMLKDMQIGVYFEEENIDTLTMDGELLLTILSSVAQQEVEN
                     TSAHVKKGLKMKMQRGELVGFQGCLGYDYDVETKQISINKKEAKIVRYIFERYLEGIG
                     GKVIARELDELGYKSPRGLEHWNDTTVLGIIKNEKYKGDILMGKTFTVDPISKRRLSN
                     FGEEDKYYIKDNHEPIISKEDFEKAQEIRLRRAGNKKTAANVNGKRERYSKMYAFSSM
                     LECGFCGSILSRRSWHCRSDYRKVVWHCVTSIKKGKKFCKHSKGLEEIAIEGAFLEAY
                     RQVYHSNENLMTDLLETIESELNDNSLNKELKRITNKLRILLKKEENLVNLRLEGKVS
                     DSIYNEKYNEISSEKEFLAEEKVNIETTLKSEIDVKKRLTEFKHLLSSQKMLTEFDRA
                     VFESIVEKIIVGGVNSNGEIDPAMLTIIFKTGEIQNKDGKQFKSKRKNAKLETDKLCP
                     QNSDEDKKLYSQGTDNTRGVCSVAGSILASQ"
     gene            complement(36580..36732)
                     /locus_tag="VXE25_000911"
     CDS             complement(36580..36732)
                     /locus_tag="VXE25_000911"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812617.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771396.1"
                     /translation="MTTNKDNDTSERSGCQRKRTAGEMPMNDLTSHTHGGNYTCYKEE
                     KVWNNQ"
     gene            complement(36863..37066)
                     /locus_tag="VXE25_000912"
     CDS             complement(36863..37066)
                     /locus_tag="VXE25_000912"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000275922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEV0771397.1"
                     /translation="MYIRLKNLREDKDLSQCQIAQYLHCSQSAYSRIESGKQDIPTSF
                     LKQLAKLYQVTTDYILEMDKFSC"
     gene            37568..38763
                     /locus_tag="VXE25_000913"
                     /pseudo
     CDS             37568..38763
                     /locus_tag="VXE25_000913"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014713014.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS110 family transposase"
     gene            complement(39142..39927)
                     /locus_tag="VXE25_000914"
                     /pseudo
     CDS             complement(39142..39927)
                     /locus_tag="VXE25_000914"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003010202.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
     gene            complement(39929..40748)
                     /locus_tag="VXE25_000915"
                     /pseudo
     CDS             complement(39929..40748)
                     /locus_tag="VXE25_000915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000240175.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-2 family transporter protein"
     gene            complement(40750..41742)
                     /locus_tag="VXE25_000916"
     CDS             complement(40750..41742)
                     /locus_tag="VXE25_000916"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEV0771398.1"
                     /translation="MKMITVEHLQKNFVKTIKEPGLKGAFRSFFHPKRQVFEAVKDLS
                     FEVPKGQILGFIGANGAGKSTTIKMLTGILKPTSGFCRINGKIPQENRQGYVKDIGVV
                     FGQRTQLWWDLALQETYSVLKEIYDVPDAVFQKRMDFLNEVLDLKEFIQDPVRTLSLG
                     QRMRADIAASLLHNPKVLFLDEPTIGLDVSVKDNIRRAITQINQEEETTILLTTHDLG
                     DIEQLCDRIFMIDKGREIFDGTVNQLKKTFGKMKTLSFELHPGQDYIVSHFEGLSDIY
                     VTRQELSLDIQYDSSQYQTADIIQQTLSDFTIRDLKMTDANIEDIIRRFYRKEL"
BASE COUNT        13085 a         9239 c         7350 g        13125 t
ORIGIN      
        1 aactttgaaa acttcaaaaa acagattttt atcgctttga acatcaaaaa agaaaggacg
       61 aaatttgtcc tttctcgagc ttagcttttc ttcaacccac tacagttgac aaagagccaa
      121 aaaattctct tttcatactc atttaaaatc aaaaagggaa tttatcgttt tacggatatg
      181 tatattacag atttctatag gtcgtgtata gacaggatat catcgcttgg aagttttcct
      241 ttttgacacc aatcagtaat ttagttctca ggaattaatg gcagtgcttt tcgtacatag
      301 tttcataact acagtatagc atagtatatc actttatagt tttcactatt gatgaactgc
      361 ttgagctgct gtgatgaggg tcaacttgta aacatcatct gcattacatc cacgagaaag
      421 atcattaact ggcttgttta aaccttgcaa aacaggtcct acagccgcaa agccacccag
      481 gcgttcagcc atcttgtaac cgatatttcc tgcctcgata cctgggaaga tgaagacatt
      541 tgcttgacca gctactgtac ttcccggagc tttcagagct gcagtttcgg gaacaaaggc
      601 cgcatcaaat tgcaactcac catcgatttc aaggtcagga cgcaagtcgt gagcaatttt
      661 agttgcttca acgaccttat caacgctttc accaaaccct gaacctttag tagaatagct
      721 caacatggca attttaggtt cgatgccaaa catcttagct gtgattgctg agttgatggc
      781 aatttcagcc aaggcttctg catctggatt gatattaatg gcacagtctc caaataggta
      841 acgttccgta ccacgaacca tgaggaaggc tcctgaagta cgagttacat ttggacgagt
      901 tttgatgatt tgtagagctg ggcgaactgt tgaagctgtt gagtgaatcg ctcctgacac
      961 cattccatca accaagccca agtaaaccaa catcacacca aagtagttga catcttcaac
     1021 caaaaccttg cgtacatctt cttcagtcat tttgcccttg cgacgctcca ccaaggcaga
     1081 aaccatttct tcaaattgag gataatgttg agggtcgatg acctcataac catccatgat
     1141 tccttcaatt tcaagataaa ttttaatttt ttcaggattt ccaagcaaaa caggaatcac
     1201 ttctgtttct tttactaagc gttttgttgc ttgaagaata cgaggctctt ccccttcagg
     1261 gagaacgata cgagcatttt taccaacaag gttggctttg agactttcaa aaacttccat
     1321 gagttttctc ctttaagata ataattatac tctgagacag tttttataga gtattagttg
     1381 ataactgggt aataaggtta ctgaaatcat ccggcaaggg actttctaac tgcaagtctt
     1441 gctctaaaaa tggatgataa aaggataggt aatggcaatg cagagcctga cgttgaatac
     1501 catcttccag actaccacca tacaaatcat ctcccagcaa aggaaaaccg atatgagaaa
     1561 aatggactcg gatttgatgg gttcgaccag tgtgcaggtg aatatagacc aagtgaatat
     1621 ttccataaga agctacaatc ttgtatgaag tatgggcata ctttccgcct ttagccactc
     1681 gtctggtaat aatggaatct tcatcacgcg caatcggagc aataatttcc ccttctggct
     1741 ccaaatgtcc atctccctta accaaagcaa agtagcgttt ctcgatagat ttcttctgca
     1801 actgcttgtc taatcgtgca tgggcataac cgtgcttggc aaagagcatc aagccagaag
     1861 tgtccctatc tagtctggta acaatgtgaa cctgctgatt ttcataattt tgcttgacat
     1921 agtaaccctt gataaaattg gcaatggtat tagagtgatt gacactagga atagaagcca
     1981 ctccataggg tttattcaag actagaaagt ggtcatcctc atagagaata tctaatggaa
     2041 gctcaatagc ctccaaggtt tcaaagcctt cctcagcggg aatgtaaatg gtaacgtagt
     2101 ctccaacgtc caatagatac gttgcatttt gcggttgatt attgaccaga atagctccac
     2161 ctcgaaactt aatcttagcc agcaatccct tagaaacctc gtgctttttt aagaaggtct
     2221 taaccttgac atgttcatct gcgataaatt caaacctcat tcatccacct caccgataaa
     2281 ggcatcctta acacggttcc agaaactggt atggctagga gtcgcgacaa agtgaatctt
     2341 atgatggtcg atttgatact caatacgctc aatattacgg aaagaataaa cgctattgtc
     2401 aaccgaaata gtatgataat cgtttcttgt tggaataagt tcaatcttat ccttcttagg
     2461 cacaataatg gaagagccca gtgttcgata aacacgatta ttaaggctgg caatttccgt
     2521 taattgcaaa gcttcaatgg tagggtgtaa aacagcaccg ccaagagact tgttataggc
     2581 agtactacca gtcggtgtcg aaactgttag cccgtctcca cgaaaacgtt caaagggaac
     2641 accatttatt acaatatctg ccaccatggt tcgatcagac ctgcggatgc tggcttcgtt
     2701 gagtgctctg aaaatcttaa cttcaccatt ttcaagaaag accttcacat tcagaacagg
     2761 gtaagaaacc cttgccccag tatctagctg caaattagtc actagcttgt ccaactcaaa
     2821 atcacgataa tctgtataga agcccaaatg tccagtatga agaccgataa agcggacctt
     2881 gtcaagctga ttttcgtact tatgaaaggc cgacaagagc ataccatccc cgccaatgga
     2941 aatgacaata tccggattgg tatcattgag tataaactga tttctcttca aacgatctcg
     3001 caattcatac aaaacccttt gactctgcgg ttttctattg gctatcagat caattcgttt
     3061 acctgtattc ttcatctgta tcgtcactgt ttcctacacc gtcatttaat tttctactca
     3121 aaggatcaaa aagtgcctgg gcttcttgga tatcatcacg aatttcaccc atttcttcat
     3181 ccaactgatg ggcgattcta gctgtaattt ccagtcgctt cttaatctca tctgggaaat
     3241 ccccttggta cttgtagttg agagaatgtt ctatcgttgc ccagaaattc atggccaaag
     3301 tacgaatttg aatttctgcc aaaatagtct tagctccatt gatggtatca accgtatatt
     3361 ctactaccac atgataggaa cgatagcctg atgcttttct atgagtaatg taatctcgct
     3421 cctgtatgat tcgcatatcc tgacgcttgt gcaaaatatc cactacttcc ttgacgtcat
     3481 ctacaaactg aaccatcaca cgtaagccag caatatcctg caaatcgtgt tccaaggtcg
     3541 cataagtaat gccacgacga gccatttttt ctttgatgct ctcaattggc ttaactcgac
     3601 cggtcacaaa ctcaattgga gaatgcttat tttgcttacg atattgctta cgaataccac
     3661 gaagtttaat ctttaactca ccaacagctt gaatgtaagg atctagaaat tcttcccatt
     3721 ctaaggtcat atattctccc ttgttctcat attatccgtc aaaaatatct ttgatttttt
     3781 ctccagattc atatacaata aatacaatgc ttattatacc ataaatccgc tttcaacgat
     3841 aaaaaaaggt aagaaaaatg aaacatttag aaattgaatt gaaaacacta ttgaaaaaag
     3901 atgaatacaa tcgtctaaaa gaccagttca caggtgtcac tcctgttctt caaacaaatt
     3961 actacatcga cacgcctgat tttgaactgc gagaaaagaa agtcgctatg cgcattcgaa
     4021 cctttgaaga ctgggctgaa ttgacactca aagtcccgca gagtgttgga aacatggaat
     4081 acaaccaaaa attacaacta aaagatgctg agaactatct gagtaaggaa gaacttcctc
     4141 aagggctagt actggatgaa ttggcgaaac atggtatcca aagtaagaac tggcaggttc
     4201 ttggttgtct aacaacgctt cgctatgaaa tgaaaacagc tattggtctc atggcactgg
     4261 atcagagccg atactttgat ataacagatt acgaattgga gcttgaagtg gaaaatcatg
     4321 agcaaggcaa acaggatttc cgacaatttt tagagaaaaa tcagatttcc taccaaaaag
     4381 ctccttcaaa attggttcga tttgtcaaaa gtatgaaaaa tagctgaaat aatctccatt
     4441 ttttggtaaa atagaaaaga taaaaataca caaatcccag ttcatatatg taaggtaaat
     4501 ataactagga tttataaagt ttacagagga cggtctataa tgtcagatag aaaaaacatg
     4561 aaacttttcg cactcaactc taaccaagag attgcacaaa aaattgccca agctgttggt
     4621 gtcccacttg gaaaactatc atcacgtcaa ttttcagacg gagaaatcca agtaaatatc
     4681 gaagaaagtg tccgtggtta tgatgtttac atcatccaat caacaagttt ccctgtcaac
     4741 aaccacctaa tggaattgtt aatcatggtc gatgcttgtg tgcgtgcaag tgcccacagt
     4801 atcaacgttg tccttccata ttttggctat gcacgtcaag accgcattgc ttgtcctcgt
     4861 gagccactta cagcaaaact agttgccaat atgctggtta aggctggagt tgatcgtatc
     4921 ctgactcttg atttgcatgc cgttcaggtt caaggtttct ttgatattcc agtggataat
     4981 cttttcactg ttcccctatt cgcaaaacat tactgcgata aaggattgct tggttcagat
     5041 gttgttgtcg ttagccctaa aaattcaggt gtcaaacgtg cgcgtagcct ggctgaatat
     5101 cttgatgctc ctatcgccat tatcgactac cctcaagacg atgcaactcg taacgaaggt
     5161 tatattattg gtgatgttga aggtaagaaa gctatcttga ttgatgatat tttaaataca
     5221 ggacgtacct tctctgaagc ttctaaaatc gttgaacgtg aaggagctac agaaatttat
     5281 gctgtttcta gccacggtct cttcgtcgag ggagctgctg agcttcttga caatactaat
     5341 attaaagaaa ttcttgtgac tgattcagta gcaacaaaag aaaaaactcc taaaaatgta
     5401 tgctacatca ctgctagtga gttaattggt gatgctatcg tccgtattca cgaaagaaaa
     5461 ccagtcagcc cactctttgc ctacaataaa aagaaataag gtgattcttt gatttatttg
     5521 gacaatgctg caacgactcc tatgtcagca gttgctattt cagctatgac caaggttatg
     5581 caagaaaccc acggaaatcc ttctagtatt catggtcatg gtcgtcaagc tggcaaactc
     5641 ttgcgagaag cccgtcagga actagcccag ttactaagga caaaacctca acatatcttt
     5701 ttcacttctg gtgggactga aggcaataat actaccatca ttggctactg tcttcgtcac
     5761 caagaacaag gaaaacatat catcacaact gccatcgagc accatgctgt ccttgaaaca
     5821 attgattact tggttcaaca ctttgggttt gaagcaacca ttatccagcc agaaaatcaa
     5881 gaaatcacag cccagcaaat tcaaaaggct ttacgtgacg atacgatttt ggtttctacc
     5941 atgtttgcca ataatgagac aggaaaccta ctgcccatcg ctgaaattgg ccaaatactc
     6001 aagcaacacc ctgctgccta tcatgttgat gcagttcagg ctattggtaa aatcccaatt
     6061 cattcagaag aattgggcat tgattttctc actgcttctg cccacaaatt ccatggtcct
     6121 aagggaatcg gttttctcta cgcatctagc atggactttg attcctatct acatggcgga
     6181 gaccaggaac agaaaaaacg tgcaggaact gaaaatctgc ctgctatcgt aggcatggtt
     6241 gcagccctaa aagaagacct agaaaaacaa gaagaacatt ttcaacatgt acaaaatcta
     6301 gaaactgcct ttctggcaga gctggagggc attcagtatt acttgaatag aggaaaacat
     6361 catctccctt atgttctcaa tattggattt cctggtcaga aaaatgacct cttactcctt
     6421 cggctagatt tagctggaat ttcaatctct actggctcag cctgtactgc aggcgttgtc
     6481 caatccagcc atgttcttga agccatgtat ggcgcaaatt cagaacgctt gaaggaatcc
     6541 cttcgcatca gtttgtcgcc acaaaatacc gttgaagacc tacaaaccct cgcaaaaacc
     6601 ttaaaagaaa ttatcggagg ttagccatat ggcatttgaa aaaatcattc agttaaaaaa
     6661 ttgtcgttac gattacactc ttagcccttc tgttaaaaaa ttcaccctca aagataacac
     6721 cttttttgaa actaaggttg gtaactatga actgactcgc cttttggaaa aagtgccaaa
     6781 cagcggtgaa ggcttccaac tcaaaatcat cattaacaag gaacttacag gggctaaaat
     6841 caatatcact gacaagtttg gccttcgtct agttgatatt ttcaaatcag aagaccacca
     6901 tattcatcag gaaaaattct acttcctcat ggatagcttg gtagaacgtg gtgtctttac
     6961 aaaatcggaa agatagagcc aaaatgtttg aactgaccta taaggactgc tatcatgtag
     7021 agcgtactct caagtatgag gatcatgagg ctctcatgtt gactttgtca ggatgtgtaa
     7081 ccttaccaga tacactttat gtgacttctc tgacttttag gggcaaaaaa gtttatcagg
     7141 ggctggtcgg agacctctac cgttttctat ctcatgcaga ttttttacat caaaactaag
     7201 atttttctta gttttttctt atttttgttg attttttcac aatgtttcta taaaatagaa
     7261 gaatagaaag gttgtgattt tgtgaaagat aaacagtttg ctattccaaa agctacagca
     7321 aaaagactct ctctctacta tcgaattttt aagagatttc atgcagaaaa gattgaacgt
     7381 gccaactcta agcaaattgc agaggccatt gggattgatt cagcgaccgt acgtcgtgat
     7441 ttttcctatt ttggtgaact tggtcgtcgt ggttttggct atgatgtcaa aaaactaatg
     7501 acattttttg ccgatttgct caatgacaac tctattacca atgtcatgct ggttggtatt
     7561 ggaaatatgg gccatgccct tctccactac cgcttccacg aacgtaacaa gatgaagatt
     7621 atcatggcct ttgacctaga cgaccatcct gaagtcggta cccaaactcc tgacgggatt
     7681 cccatttacg ggatttctca gatcaaggat aaaatcaagg atgctgatgt gaagactgct
     7741 atcctaactg ttcccagcgt caagtcacaa gaggttgcta atctcttggt tgatgctggt
     7801 gtgaaaggaa ttctcagttt ttcaccagtc catctgcatt taccaaaaga cgtggtcgtt
     7861 cagtatgtcg atttgacaag tgaactccaa accctcctct acttcatgcg aaaagaggat
     7921 tagaaagcga aaatcatttt atgaaaaaac cagttattgg gattacagga aacgaaaaaa
     7981 ctcatccaga tgatgacatc atgatgagct acgcagcaaa aggctttgtt gaaggcgtta
     8041 aagatgctgg agggattcct atcatcctac cgattggtga tcaagaaatg gcctgccact
     8101 atatcagttt gattgacaag ctcatcttga caggtgggca aaatgtcgat ccaaaattct
     8161 atggcgaacc caaaaccatt gatagcgatg attatcacct tcaaagagat atcttcgaac
     8221 tggccctcat caaggaagct attaaacaga aaaagcccat tttctctgtc tgccgtggta
     8281 cccaactctt taacgttgcc atgggtggaa ctttgtacca agatatcgaa gaccattggc
     8341 aggattcttc tgttgagtac acaactcaac gcttggtgac agaaccagat accgttctcc
     8401 aagaaatcta tggagaaatc tctcatatca actccttcca ccaccagagc atcaaggact
     8461 tagcaccaaa tttaaaagtt gtggctcatg atcctaaaga tggtatcatt gaggctgtca
     8521 tgagtacgga tgatgtcgcc tttctcggtg tccaatggca tccagaactt ctttttgaaa
     8581 atcgtcccaa agataagaaa ctctttgact atgtcgttaa tgaactttag attaaatctg
     8641 tcttttcacg ataactaaag taattagaat gagagacaat caaatggtcc aagagaacaa
     8701 tccccatcag ttcgcaggct tctttaacaa gtttagtgac atgatcatca ttttggctag
     8761 gcgctaccgc tcctgaagga tgattgtgga ccaagataag agaagtcgcc atgtgcttga
     8821 ttgcatagtg aagaatctct cgcggttcag cgatactacg agttacagaa ccgataaaaa
     8881 tggtctgctg atggatgatt tgattttgag tattgagata gagtgccacc aggtgctctt
     8941 gttttttatc ccctaattcc tgctgcatct tcttggccaa cttttgactg ctgagaatac
     9001 tttccatttc aagagtctcg tgtttgtgaa tacgatgccc cagttcaatc atagcttgta
     9061 attctatggc cttaacacgc ccaataccag acaaactctg caattcctgc agggtcattt
     9121 ttttcaaatc cgttaggctt gaaagattgt tcaagacttt ttgggcaatt tcaaaaacgc
     9181 tagcttgacg tgttcctgtc ctgagtaaaa tagctagcaa ctcttggtta ctaagcgctt
     9241 caactccttc cttggccagc ctttctcttg gtaatagtga atcttcttgg aatgaaatac
     9301 tgtacataaa aatcctcctc actttattat tcgtgagaag gatggaaaat tagatttttt
     9361 tctcaattgg agccacactg gctaaaagtt ttttcaaacc tacttctggg aaattgattt
     9421 tcaattcctg cctagcaccg ctacctgaaa cttccagaac ggttccctct ccccatttct
     9481 tgtggagagc aatgtcacca atggaccaat ttgcctcgat agatgctgat tttgcgccag
     9541 ctgtaaattg accaaatgga agaccgcttg actggattga ttttggggca gcaccgcgtt
     9601 tacggtcttg aagagcctga gccaaactca taccttgacc aaaggaaata ctaccactgc
     9661 tatatgatgc cttaaagctt gtatttgcag gacgagccag accttgatac tcaagcaagt
     9721 ctgaactgat ttcgttaata aaacgagtcg gacggttata attggtacga ccaaaaagca
     9781 agcgtgagtt ggcattggtc agatagagaa ttttctctgc acgcgtgata cctacatagg
     9841 ctagacggcg ctcttcttct aattcatctg gatcttcagt cgcacgacta agtggaaaga
     9901 cattttcttc catcccaatc aaaaagacaa ctggaaattc gagaccttta gcagcatgca
     9961 gggtcatcaa ggtcacttct gatgtctcct gactacctga atctgtgtcg gcaatcaaag
    10021 ccaagtcatt taagaaacga ctcagtttgt ccagaccagt ttcctcttct gccacatcag
    10081 tggtgtcatc aaagttcttc gtaacagaaa gaaactcttc gatattttca acccgagcct
    10141 tgctttctag agtcgcttgg gcgttaagaa tatcgacata acctgttttt tctaggacgg
    10201 actcaaccaa ctctgtaatg cttaagtggt ctagctgctc ccgcaaatca agcatcatat
    10261 tggcaaaatc ccagatagat tgggctgcct tacccttgat accagacaac ataatattag
    10321 cagaagcatc cagcatagac atattttgca aatttgcaaa atcacggatt ttctcaactg
    10381 tacctggacc aattccacgt ttaggctcgt tgataatacg ctcaaaacta atattgtcac
    10441 tcaaattagc aataaggttg agataagcaa taatatcgcg aatttcctta cggctgtaga
    10501 atttggttcc gccaaccatg gtataaggaa tgttagactt gagcagggct tcctcaattg
    10561 tacgggactg ggcattagtc cgatagagaa ctgcaaaatc cttatgaagg aagttttgac
    10621 tgcgactaag ttcatcgatg gttctggcta caaatacagc ctcatccagc tcatcatcgg
    10681 cacaatagta aacgatttgc tccccatcag cgttttgagt ccagagattt ttaggacggc
    10741 gatttttatt gtttttaata acctcgttgg ccgcttggag aatggttttg gttgagcgat
    10801 aattttcttc caacaaaaca accttggctt tggggtaatc cttttcaaag tccaagatat
    10861 tctgcatatc agcaccacgc caaccgtaga tagactggtc cgcatcccca accacacaga
    10921 tatttttaaa acgggaagcc aagagtttga ccaattggta ctgagcgtgg ttggtatctt
    10981 ggtactcatc aacgtggatg tattggaatt tttgctggta gtaggtcaaa acatcaggat
    11041 tttgatcaaa gagacgcaag gtcagcataa tcaaatcatc aaagtcaacg gattcagact
    11101 gacgaagttc tttttgatag gttgtataac actgggccac aatttgcgta tacatatcgc
    11161 cagcttgggc agcataagca acatcatcaa tcaaatcatt cttagcattg gaaatggtcc
    11221 ccaaaatagt tcgttcattc cattttttag gatccaagtt caactgtttg agaatacgtt
    11281 tcatgagcgt tcgctgttca ccaggatcca caattgtaaa attacgattg tagccaatat
    11341 ggtccgcatc gcgacgcaaa atacgcacac acatggagtg gaaggtcgca atcagacagt
    11401 cctgagtagc tggattgagg ctataagcac gctctttcat ctcacgcgca gccttgttgg
    11461 taaaggtaat ggccaagata ttccaaggat tgaccagctt ttcatcaatc aaataagcga
    11521 tacggtgggt taaaacacga gtctttccag aaccagctcc tgccatgatt agcaagggac
    11581 cttctgtcgt ttgcaccgcc tcagcctgac ggtcattcat tccatttaat aatgcgttca
    11641 tcttctcttc cttactcttg aagtcaatat ttctattata tcagaaatca gggaaaatag
    11701 aaactttacg gggagtagca aaatatagtg gattgaaact agaatactac actgtgggtt
    11761 tctaaaacac tcgacttttt cacccaattt tttcataaac tagctcaata cctcaataga
    11821 cttcctgcaa aactagaatc ctagttcatg attgataatg ccagcaatca aattcgttcg
    11881 taatccgaag cgtttacgat gatttcgata ggttgttgaa aacattttaa acgtttttac
    11941 tttggcaagg atgctctcaa ccttgcttct ctccttagat aacgcatggt tataggcttt
    12001 atctttaact gttagcggtt tgagtttgct ggatttacgt ggagtttgtg cttgaggata
    12061 tatcttcatg agcccttgat aattactgtc agccaaggtt ttaccagttt gtccgatatt
    12121 tctgcgactc attttgaaca acttcatatc gtggcaatag ttcacagtga tatccaaaga
    12181 aacaattctc ccttgacttg tgacaatcgc ttgagccttc atagcgtgaa atttcttttt
    12241 accagaatga ttggctagtt gattttttta ggacgattta tttttacctc tgttgcatcc
    12301 acaatcaccg tatcctcagc actaagatga gtttttgaaa tcgtaacacc actttgaaca
    12361 agagttactt caacccattg gctccgacgg agtaagttgc tttcgtgaat accaagatca
    12421 gccgcaattt cttcataagt gcggtattct cacacatatt gaagagtggc cataagaagg
    12481 tcttctaggc ttaatttagg ttttcgtcca ccttttgcgt gtttaagttg ataagctgtt
    12541 tttaatacag ctaacatctc ttcaaaagtg gtacgctgaa caccaacaag acgcttaaat
    12601 cgtgcatcag ttagttgttt acttgcttca tcattcatag aactactata ccatattttg
    12661 tttcgcaggg agtctaatat aaaaaaataa atttaagatt ggcaatacga acgttaaaca
    12721 gaattccatt tctcttttta gaatcaaaac gacaatattg tggaatctct acaggaacaa
    12781 tagactgcga cactaaaata tcctccctta gttttacttt actaatagta tataggagga
    12841 gagccctgaa tcctagaccc tttgttatga tgcgcttaca aacagagttg gaaaaaatct
    12901 taaaagcaga aaaacgcatg atatcagccc ctaacacttg atacaatgcg ttttattatg
    12961 aaaaaatcta ctggattttt tatcaaaata aacttccagt agtcttttca ctttttatta
    13021 ataagttcct tcttcacctt ggctagtcaa gataacaggt ccatctttcg taatgacaaa
    13081 ttggtgttca tactgacatg acaatccacc gtcaatggtc ttatgcgccc aaccagtttt
    13141 catatctgta tcaatttccc aatcgcctgt attgatcatt ggttcaatgg ttaagaccat
    13201 tccttcacga agacggagtc cacgacctgc aataccatag ttaggaacca ttggttcttc
    13261 gtgcatagtt gggccaacac catgaccaac caaatcacgc actacaccgt aaccacgact
    13321 ttcagcgtat tcttgaatag ccgcaccgat atcaccgata cgatttccaa caacagcttg
    13381 ctcaataccc ttgtacatag cttctttggt tacatccatc aagtttttga cttcttcgga
    13441 cggtgtacca acagcataag cccaacatga gtctgctaaa ccaccagaat agctctgagt
    13501 gtattttttc atttgttcaa cattgttgaa gtttaatttt gagacattta ggtcagattt
    13561 agcaatggga cctcccaaaa ccatatcaac tttgagcaaa tcaccatctt tcaagatata
    13621 atgacgaggg aaagcgtgag ccacttcatc gttaagagag caacaggtag cataaggata
    13681 gtccatcatg gcaccgtcaa ccccaatctg aagtggaagg aaattttctt ctttacaacg
    13741 acggcggaca tattcttcaa cttcccacat atctacgcct ggcttaatca aatcacgtaa
    13801 gcctatatga atacttgcta gaaaatcacc agccttgtcc atagcttcga tttcacgagc
    13861 tgattttaat gttatcatct tttctcctag tttctaatta attttaacag tcacatttgc
    13921 ttttgaaaca atctggtgac catgataaat atcgtaatca attatagctg accgtctcgt
    13981 atgatgaata atccgtgcct gaatgcgcaa tatatcatct atctgaacgg cctgcaaaaa
    14041 gtagatcagc atctgctcga taatgagatt gcgaccacta ttaacaacta aatcttgggt
    14101 catgtgggtc agaatttctg ccaatacacc attagccaaa actccatttt tttctagcat
    14161 aaagggttcc actgtaatga ctacttcatc atggtgataa gagagctttt gtccaatctg
    14221 ctcagaaaaa gttggtagag ccgaaacttg ggaacggctc atcttctcca tgacatctcg
    14281 tcgcgtcaca acgccaagca aagtttgatt gcttcgaaca actggtacca tttcaaagtc
    14341 ttctgcgatc atccgttgac tcacattggc aatatttgtc gataatccaa ccaaaaatag
    14401 actacgagac ataaccttat caattgtcgt gcttggtgat ttatcaccag cgtctctcat
    14461 ggttacaacg ccaacaacga cctgatgttg attgataaca gggaaacggc tgctacgatt
    14521 cttacgaacc aagtccaaat aatctttaac tgtatctgtc tctctcagaa aaccatactc
    14581 atgactaggg cgataaagtt tctcaactgt cagaatatca gtcttgattt ggacatttga
    14641 caaggcttta ttgatcatgg tagcgacggt aaaggtatca tgcttacttc ttagaacagg
    14701 aatccctttt tgattggcca gtttaagcac atcatcatga acctgaaatc cccctgtaac
    14761 cagaactgca ttttcatttt ccaaggctag caactgaata cgggttcggt ctccgacaat
    14821 caagagcccc ccatcatgaa ggtaagacaa gatattttgt tcagtcatgg caccaattga
    14881 aaacttacta aattctctct ctaaaccttc ttgcccagcc agaacctcag aagaagtcac
    14941 ttctgcaatt tcagcaaacg ttaatctatc tatagcaact ttctgggatt taacacgaat
    15001 tgttccactt ctaggacggg tctccacaat tccacggttt tcagcttctt taatagctcg
    15061 ataggctgtt ccatcactaa ctcctagatg attcgaaatg ctacgaacac tgaccctttt
    15121 acctactggt aattcctcca aatagcttag aatttcctga tgcttactca ttgaactctc
    15181 cttttacata ccgaaattca agataatccc gcatttttct tgtgtaacga tcacttccct
    15241 taaactgacg gaacaaacta aatccagact taagagcaac tctttggcta gcttcatttt
    15301 caaggtgggt aatgataaat aattgtttta agccaaattc ctcaaaagaa agctgacaaa
    15361 tttttctaac aacctctgtc ataaatcctt gcgaccaagc atcttttctc aaaaaatagc
    15421 caagctcagc ttcttttttg atttcatcta acttctcaaa tttaatagaa ccaatcattt
    15481 gttgattttt ctggtcacaa attgcccaca ctcccaaagg ggacttcata aagtaattgg
    15541 ccagtgcata ttgactttct tccagacttg cctgcgttgg gaaaataaat tgaagatttt
    15601 ctggatttga agctatctcg cggaagtcct gactatcact aaaaaagaaa ggacgcaaat
    15661 acaagcgatc cgtttcaaaa aaagaaaaca ttgctaattt ggtccaaata ttcataaaca
    15721 cctctacggt ttaatcctca acaagtctaa tatccgctcc taaattacgt aatttttcga
    15781 taatatcaga ataaccacgt aagataaact cgatattggt aatttcagtt ttaccttcag
    15841 ccataagccc agcaatgact agtgcagccc cagctcttaa gtcggtcgct ttaacactgg
    15901 ccccacgtaa atcacgtcca cccgtgtaca aaatatgacc atttgttgtc gaaatatccg
    15961 catccatctt tgctagttca aaaacatgat ttacacgttt ttcgtaaatc gtatcgacaa
    16021 ttgtaccacg accattcgct cttagtaaaa gaggggtaag cggttgttgc aaatcagttg
    16081 caaagcctgg gtaaggagct gtcttaatat tgattgcttt caaattagac tgttcctcga
    16141 caaaaatgct gtcttcagat acagtcattc tcactcccat ttcttccaac ttagcaataa
    16201 acccttccag gtgttcgtaa agaacattat ttatacgaat tcctttacca actgcagcag
    16261 ctaaagatat atatgttcca gcttcaatgc ggtctggaat cacctgatga cgtgtcccat
    16321 gtaatctttc aacaccatca ataatgatga tattagttcc tgccccacgg atatgggcac
    16381 ccatattatt caagagagta gctacatcaa taatctcagg ttcacgggct gcattttcaa
    16441 taatagtacg accatttgct ttaaccgcag caatcatcgt attaatcgtt gctcccacac
    16501 taaccgtatc catgtaaata cttgcaccat gaagtcctgt atctttagca gataacttca
    16561 tgttatctcc ctcgtagcta gcagtggcac ccatagcttc aaacgcctta aggtgtaagt
    16621 caatcggacg aggaccaaga tcacatcctc ccggtagacc aactgtcgct tcaccaaaac
    16681 ggcctaagag gctcccataa aaatagtaag atgcacgaag actgttaatt ttaccataag
    16741 gcattggaat attttgaaca cctcttgggt caatctccaa tacatcgtca taacgcttaa
    16801 cagtagctcc catcaattcc atgatttcga caagactggc tacatccgaa atatctggaa
    16861 cgcaatccaa agtcaccaca tcatcagcca agataatagc tggaattaag gcaacgacac
    16921 tatttttagc accactaata gtgatttcac cttgcagtgg taatccacca ttgataacaa
    16981 tttttctcat tctaagtttt caatactctt tcaagatttc taataaggtc ttcaaaataa
    17041 agtatatcat aaatttatcc ttttttccat ccttttcaat tttattggat aaatcagagt
    17101 tgacgagtta gtaactgaat tactaatact caatgaaaat caaagatcaa actaggaaac
    17161 tagccgcagg ttgctcaaaa cactgttttg aggttgtaga tggaactgac gtagtcagta
    17221 tcctacatat acggcaaggc gatattgacg tgatttgaag agattttcga agagtataat
    17281 ctttctcgaa tcgctattgc ccctttttta tcccctaaaa ctgagtagga tctaagacta
    17341 gatctcttat ctaagtatcg gaatacggct gttcaactaa attttagcaa gaacttctcc
    17401 ccttctctca gttcacagaa gcgttttata cataccgtcc tatcagacaa tctattttaa
    17461 agataaccgt gactcaggat cacttctatc tgtcgttttc tctttatagt gatagacctc
    17521 acgggataag tcgtacatct ttcctcgtgt atacaagata taaggacgtt aaaaggttac
    17581 agtgaaaata gaaaatctta gtacgaattc aattactctc gtgatttacg catataggtt
    17641 acgactacct ttttggactt tagagtttga gaccccctta tccgctatat acgccttact
    17701 atcacgttcc tgttcgtaaa gccacgattt cgctatccct tcctctgacg attcttattt
    17761 ccagcgtcag acttaaaacg gtctatcccc agaccgtttt aatccactac ctcacgatag
    17821 tcaggcttgg gaatcgctat ttgactcgcc gagaactttg acatcagata tactataaca
    17881 aattgaaata agaatcaaac aatttaattt tgaaattcaa atcaatttat aacaatattt
    17941 tagaagatat gctgtgctat tccagattca gtttgctata catgcctgtc gtaccacaaa
    18001 atcccgtgtc tgatgaggca cgggattttt tagcttcttt actgagatgg attttccttt
    18061 ttagttcgtg ccaatctcaa ggcacgattt ggattgagac gattaaatag ttcttccaat
    18121 ttcttttcat tccaaacgtc tgcggcggaa acaaaattac catccgcatc tcggaaagat
    18181 atcggtttat ctcccatacc agtctcctag tctacaaatt caaactcaaa tttaccaatg
    18241 cggaccaaat ccccatcttt agctccacgc gcacgaaggg cttcatcaac ccccatacca
    18301 cgaagctgac gggcaaattt catgacagat tcatcacgat caaagttggt catattaaag
    18361 agtttcatga gtttttcacc agaaagtacc catgtcgcat cgtcatcacg actaatttca
    18421 aaggcttttt cttcttcgtc aaatccatag taagcttctt cttccatatc ggactcgtcg
    18481 tagagcaaaa attctggtgt cttgtctaac aattcagctg tagcatctaa aagtgttacc
    18541 agaccttgct tggtcaatcc agaaattggg aagatagctg gtaactcttc aaattcatca
    18601 taattttcag ccaatttttt cttaaattct tcaagatttt cctgactctc aggcatatcc
    18661 atcttattag ctacaataat ctgtggacgc tccatgaggc gaagattgta agactccagc
    18721 tctttattga tagctaggta atcctcatat ggatcacggc cttcgctagc tgacatatca
    18781 atgatgtgaa ggataacacg tgtacgctcg atatgacgga ggaactgagt tcccaaacca
    18841 acaccttgac tagccccttc aatcaaacct ggcaagtcgg ctactgcaaa ggattcacct
    18901 gattgggtgc gaaccatacc taaatttggt acaatagtgg taaagtggta ggcaccaatt
    18961 ttaggcttag ctgaggtaat aacacttaaa agtgttgact tccctacaga tgggaatcct
    19021 actaaaccga catctgccaa gatttttagt tccaattgta actcacgttc ctgacctggt
    19081 tctccatttt cagagatttc cggtgcagga ttttttggtg tcgcgaaacg aatatttcca
    19141 cgtccaccac gaccaccgtg ggcaacgata aattcttgcc catgttcaat caaatctgtt
    19201 aaaaccttgc cagtctccgc atcacgaaca gtcgtacctt gtggtactag aactctaagg
    19261 tcctcagcac cacgaccatg catccctttg gtcatccctt tttcaccaga atcagccttg
    19321 aaatgacgat tgtagcggaa atccatcaag gtacgtagtc cttcgtctac aacgaagacc
    19381 acattgcctc cacgaccacc atcaccaccc caagggcctc cattagggac atatttttca
    19441 cgacgaaagg caaccatacc atcgccacca ttaccagcct tgaccttaat cttagctgta
    19501 tctaaaaaca tactcattat ttcttctcac tttaaaaaag ggctgggaaa tcccagtcac
    19561 taaattttct tgaatctatt ttatagatta ctgagggcac caattgcagt tgcaaaaatt
    19621 cccaataaac ttgctactag catgataatc acgataaaca aggttatttt ctcaaacata
    19681 gtttttttac gatttccatt atctccaaat gccatttttc tctccttcgt tacattctat
    19741 tttctattat cttagcatga attgagctag ttttcaatag tcagttgcta ctggtgcgat
    19801 aatccataaa ataatgtaag ctacaattcc agctccgtaa cagcaagtaa gaacacccca
    19861 aatgactcga acgatagtcg gatccatatc cagataatag gccaccccag cacaaacacc
    19921 cgcaatcttt ttatcacgac cgcttctcat taattgtttt tttcatagct gttcctcttt
    19981 ctattcttca tggtctttcc aatagtctct catactgatc aactgtgttt ttgaagcctt
    20041 caacatgcgt ctagaacctt ttacaggtac agcaaccacc tgttgcggaa gatacaaaac
    20101 tgtcttaaag atacgctgac tgaccgtatc atctttagcc aaatctttct ggaagttatt
    20161 tgaaataata gcatccagat aaaactcatg cactcgtttc ccaaagttct cagctgaaat
    20221 ctcatacaat ttctctgata aggtatgctc gttcatgtct ggtgttgcaa tcagggcttc
    20281 caaaatagca ccagccaaat catgttctcc atagtacaag gttccaaaca ttttatcact
    20341 gatgaggttg ttcaaataag gatttccgtg agcaatgaca ggtgttccac tggctaagct
    20401 ttccaagtag gtcaaacctt gcgtttcgct tgtcgatgcc gaaatgaaga aatccgccgc
    20461 tttatagtaa agagccgtct cactaggagc aatcatccct gtaaagatga ctgagtcttg
    20521 aatctctagg ttctgagctt gctctttgag gtcattcaga taagggccat ccccagctac
    20581 taccagttta accttgtctt cctctttcag aacatcagca aaggctgcta aaactgcttg
    20641 aatatttttt tcataagaga ttctcgaaag actaagcaac gtcttttcac catcttgaat
    20701 ccctagttta ctacgcagtt ctttcaaatt ttcctgcttg atttccggac gctcaaactt
    20761 ggctaattca atcccagtag gaatgacccg tttttcaacc ttgaccttat aatcagatag
    20821 caagtcacgg acaatctcac taggacaaat aaccccatcc acatcatgca ggaaacctct
    20881 aaccagatac ttgaccatac tcggccggat caacatcccc ttagcaatat aatggacata
    20941 gtcttcatac tgggtgtgat aggtatggat gactggaatt ttcaattcac gcgcaatcca
    21001 aatccccaac aggccaagag aaaattctgt ctgagtatgg ataatatcta gctgatactg
    21061 tttagcaatt tcaagtgcct tgctaaaacc tcggtaggca aagcgacgat ccttaaaagc
    21121 aaagaaagga acacttggaa tgcggataat ttgccaatct tcgtagcgat tgacatcctt
    21181 atctgtcgtc gtaaagataa aaacagcatg tccctgcttt tcaagttctg ttttcaaggt
    21241 tcgaatactg gtcgcaacac cagaaacctg aggaaaatag gtatctgtaa ataaaccaat
    21301 tcgcatagat tacctcactt tttactttct ccctaaagcg gcttgtttct cataaaagtc
    21361 caaccagatt tgtaacagat tctcttcaga atactctctg gaaatattct tagccttttc
    21421 tttgagatct tttaaggcag caggatttgc ttgatattcc aaaatagcct ctttcatctc
    21481 ttctctaccc gctgtcgccc gataatttcc ctccaaaatc accttataga gatctaaatc
    21541 acgcaacata ataggagcct cacaactcgc agcttctaaa atagtcatag gaaagagctc
    21601 attgtaacta ggcaacaaga aaagatccgc tagagcatac aattcgcgca tccgctctgg
    21661 cgatacaatg cctggaaaaa tcaaattttt agggggattt tccataattt tcttatagtg
    21721 ttcataacca tctgtcatac caccaaaaga gaagccacca gcccagataa aggtaatctg
    21781 aggcaattcc tcagccagac ggataaagtc atcaatccct ttacgtttct gaacttgccc
    21841 agcacctact acgataaact gattgtcact aagaccaaga tctgtgcgca gtctgactac
    21901 ctcttcttgt ggtagaggat gccatttttc cttgttgaca aagttaggaa tataggtcac
    21961 tttttcacgt ggaataccag ctgctaccaa atcctcaata aacataggat tgaccacaac
    22021 caagtgctcc atccggttgt aaaaagaaaa tacatagcgt ttcacaattc cctttaagaa
    22081 aaatggaatt ttcaaacttc cctcaagtgt agctggcaag aaatgcacat agccaatctt
    22141 tctccctgag cgtttctttt ggaaggttga taaataatag ggaaaatcaa tcgtatgaaa
    22201 gtgagtcaca tctgcctcga ttggaagatt ttctgtaaca atcaattggt ccttggcagc
    22261 acggtgaaga agacgaacta attcacggta agcacctgaa actccctgtc ctgctacttt
    22321 ctcacttgaa ctcaacatat tgatgcgtaa tttctttttc tccataacta ctattatatc
    22381 attttctttg aataaaatca gcaaaagaaa ggagagacta gaggaaaaga ggggaaattt
    22441 cctcgctttt ccaacagtct ctcacatgct tttatatgtt tacttaatgc ctagggcaat
    22501 gcgggcatag cgactcattt tttcaactgt ccaggctgga taccagacta atttaacctc
    22561 agtatccgtt acttctggaa cctctatcat agcatcataa atctggtctg tcaaaaggtc
    22621 tgctaaggga caacccatag ttgtcaaagt catgtcaatc tctgtttgcc ctgtgtcacc
    22681 gtcaaaacga atctcataga tcaaaccaag attgacaata tcgattccca actcagggtc
    22741 gatgacttct tccaaggctg ttaaaatccg tgttttgatg ttttcaattt gctcttctgt
    22801 ataagccata ttttcctcac tcttagtctt caataaaatc acgaagcggt ttgctacgac
    22861 ttggttggcg tagttttctc aaagcctttg cttcaatctg acggatacgc tcacgagtta
    22921 cgttaaagac tttccccaca tcttcaagtg tgcgcatttt tccatcatct agtccaaaac
    22981 gtagacgcag aacattttct tcacggtctg taagagtatc taagatttca tccaattgct
    23041 cacgcaagac gatacgagtc gtataatcca ctggattttc aatcacttca tcttcgataa
    23101 agtctccaag gtggctatcg tcctcttcac cgataggagt ttcaagagat actggttctt
    23161 gggcaatctt caagatttca cgaaccttat caggtgtcat atccattcgt tcagcaatct
    23221 gttctggtgt cggatcttgc cccaattctt gaaggagatt ccgctgttca cgaaccaatt
    23281 tattgatagt ttcaaccatg tgaactggga tacggatggt acgagcttgg tccgcaatag
    23341 cacgagtgat agcctgacga atccaccaag ttgcataagt tgaaaacttg aaccctttag
    23401 aatagtcaaa cttgtcaacc gccttcatca agcccatatt tccttcttga atcaagtcaa
    23461 ggaactgcat accacgaccg acatagcgtt tggcaatgga aacaaccaaa cgaagattgg
    23521 cttccgcaag acgttgtttg gcttcgatat caccagcttc aacagccagt gccaactctt
    23581 tctcctcttc attggtcaag agaggaacga cccctatttc tttcaagtac atacggacag
    23641 ggtcattgac cttagcagaa gttgacccaa tcaagtcctc atcgctgagt tctggttctt
    23701 cttcattgct gagaacacgc gcacttggat ttccttcgtt atctgtgata gaaatgcctg
    23761 catcctgaat ccgttgcaag agatcttcaa tcccatcagc gtccaaggta aaaggaataa
    23821 ccagacttgc attgatttca tcatctgttg ctgtcccttt ttgcttatga ttacggataa
    23881 attctgctac ctgtacgtca aatgttgtta cttctttttg ttttgttgcc attattactc
    23941 cattcttctc ttttgggaaa ttaaacgttc caattcttct agggctgtat ctgtatctcc
    24001 tacatggcta gcttcctgca ccttcttttt gattctcata ttgtcctgat tcaagagagc
    24061 cttgtttcga gtcatctcta cttcactaag ttcctgcggc gatatctcag caggcaaatc
    24121 ctgagctaaa acttggtacc aagctctttc aacttcctct gtctgctctg ctaaaacttc
    24181 tggaggaaga tttccatact ggccaagcaa gtcatataag acctgaaatt caggtgtagc
    24241 aaatgcaaag tcttctcgca aacggtaatc gttcaaaaca agaggggatt ccatcatccg
    24301 atagagtaga tgggcttctg ccctcataat agccgataac tgcttggtga caggcatggt
    24361 gattggcgtc ggtctggaaa ttctttccat gcgattctgc ctttgcacct gacgactctc
    24421 attaacaatc tgctcaatct gggtataatc aaaggacgcc agactgtcag ctaaaatatg
    24481 aatatagctg ttttgagcag cgatggactt ttcttgaaca atcaagggag ctattttttc
    24541 aataaactca atctgagcct gcagattttc actgttttca ggtttgtact gatgaatgta
    24601 gaactcaatc ggactaatac gagtttttgt taatagatag gccaagtctt ctggaccatt
    24661 tttttgtaga tactcatcag gatccaagtt atcaggcatg ctaacgattt gcgcaggcat
    24721 atcaccaatt tcatccaatg ctttcaatgt cgcggcttgc ccagccttat ctccatcgta
    24781 aacaagaacc aatttcttgg ttaacctttt cagatgctca acatgctctc gactcaaggc
    24841 cgttcccatc gacgccacag cattttcgat tccagcccga taggctgcaa taacatccat
    24901 gaatccttcc atcaggtaaa tctcactagc ttttccagaa gatctttttg ccctatccat
    24961 atgatataat tcgtaacttt tgttaaaaat tgcagtcgat cggctgtttt tatacttaga
    25021 agtttgtgaa tccgtttttt gccagatacg acctgagaag gcaatgacct ttccttggtc
    25081 atttgtcagg ggaaacataa tgcgattgtg aaaggtgtct acaaattgat tggcatccga
    25141 gagataaaac aggcctgaat ccagtaaatc ctcttcacga tactgatcag acaaacgttg
    25201 atagagatag tttcgttctg gaggtgctaa accaatccaa aaatgtttaa gcacttcatc
    25261 tgtcaaaccc cgctgataaa ggtaatttct ggcctcttcg cccatagtcg ttgtcatgag
    25321 aatagcatgg taaaatttgg ctgcatcttc gtgcatatca taaagatctt ggtgaggtga
    25381 ggctgacttt tgctcactat aaagcggttt ttcaacctca attccaacac gctgacctaa
    25441 gatttggact gcctctataa agggaacccc ttggtactcc tctatgaact taaagacatc
    25501 acctgagcga ccacaaccga aacagtgata aaactgctta tcctctacaa cgttgaaaga
    25561 aggtgttttt tcaccatgaa aaggacagag ccctagatag ttccgtcctg ccttttgtaa
    25621 agaaatcaca tctcctatga cttccacaat gttggcattg tttttgattt cttcaatgac
    25681 ttgtttgtca accatacaca atacctccat gttatcatag tttactttat atagtatact
    25741 ttatttcaga aaaaaagtaa accatttcac tcattttcct tactttattc aaagagttga
    25801 taataatcag agattttcat ttttgctttt tcttcttggt ttaaatcttg gataatccgt
    25861 ccttctttca tgacaatcaa gcgattgcca tatttgagag catcttccat atgatgggta
    25921 atcataaggg ctgtcaattg atctttctta acaaattcat ctgtcaattc catcaaagca
    25981 acactagtct ttggatccag ggcagcagta tgctcgtcta acaagagtaa ttcaggtcgc
    26041 ttcaaggttg ccatcaagag actcaaagcc tgtctttgtc caccagataa gaactcaatc
    26101 ggtgtattca agtgtttctc aagaccgttt cccacttttt caatggtcgc ctgaaactta
    26161 tccttatagc tagccagacg tctcggaaat agtccacgct tttcaccacg aaacttggca
    26221 atcaggagat tctctgccac tgtcatacga ggagctgtcc ccatctttgg atcttggaag
    26281 actcgagaca gatacttagc gcgcttctct ggtgaaaact tggtaacatc ctcacctaaa
    26341 atacggatag ttccactggt tagtgatatg gttcctgcaa tagtgttaaa gagggttgat
    26401 ttaccagcac catttccacc caaaatcgtg ataaagtcct gttcaaaaat ttctaaggaa
    26461 acatcattta aaataatctt ttcttcatca aagccatttt taacgatttt ggttgcattt
    26521 tttaattcta caattgctgt catttgctta acttggctcc tttcaagatt gtttgcttaa
    26581 atgttggaat catgaggcag actgctaaaa tcaaggcact gtataaacga aggtaacttg
    26641 tattaaagcc aagtgcgata actgcccaca ctaaaaattg ataagcgata gaacctacaa
    26701 cgatagtaac caaacgctct gccaagctca aactcttgaa aataacttct ccaataatca
    26761 aacttgcaag ccccacaacg ataaccccga tccctcgaga cacatcggca taaccttctt
    26821 gctgagcaat gagggcacct gcaagggcaa tcacaccatt tgataagacc aagcccatga
    26881 gctccatgcg tccagtatga atcccgaaac ttctagccat atcaggatta tcccctgtag
    26941 caatataggc ttgtccgagt ttagtgtcca agaaaaagag catgagagca ataacaatac
    27001 tcacaaagat gagacctgtc aagagttgat tcaaatccga atcaaaaggc aaaacatcct
    27061 gaatttgctt ggttccaagc aggcctaaat tcgcacgtcc cataatcaag agcatgattg
    27121 agtgacaaga agtcatcacc aaaatccctg agagcaaggt tgggatcttc ccttttgtat
    27181 aaagaaggcc tgctgccatt ccagccaaac aacctgctcc tacagcaaca agtgtcgcta
    27241 aaaatgggtt cacgcctttg gttatcaaag tgacagcaac agctccccca agagggaagg
    27301 aaccttctgt cgtcatatct ggaaagttta aaatcctaaa tgtcataaag attcccagac
    27361 ctagaatagc ccagacaaat ccttgagaaa taatggaaac aatcatattt tatttaatcc
    27421 tttctatatt catcttttta aaaaatggga agagtctcct cctccctacc ttatttattc
    27481 gatgacttgt cctgcttctt tgagaacaga ctcaggaata gtaataccta gttcttgtgc
    27541 tattttttta ttgatgactg acttaccagt tgaaaagaca ttgactgggg tatcggctgg
    27601 ttttgcacct ttcaagactt gcacaatcat tttacctgtt gccacaccaa ggtcatgttg
    27661 gtcaattaca actgatgcca aaccacctac ttctaccata gctgtcgcac tgggataaat
    27721 tggtttctta gaactttgat tgctagagac aaccgttgga aatcctgatg caatggtgtt
    27781 atcaattgga acccaaatag catctacctt gctagtcata acagtgacag ttgaggcaat
    27841 ttcatttgtt gaaggaactg caaatgtttc cactgtcaga cctgcttttt cagcataagc
    27901 cttaaattct tcgacctgtg tttttgaatt gtcttcgcta cttgagtaaa gcgctccgat
    27961 tgttttcaca ttcggtgtca gagccttgat gagttcaact tgttgttgag ctggattgtg
    28021 gtcagatacc cctgtaacgt tgccacctgg ttttttcaaa tctttaacca agttagcacc
    28081 aattgggtct gtaatagcgg ccatgataac cggtaggtct tttgttgcac tagccaaccc
    28141 ttgggctgct ggtgttgcga taccaaccac aaggtcattc ccatttgcaa ccaattgttt
    28201 actcattgtc gcaaccttac tttggtcacc ttctgagttc ataaaatcaa ttttaacttg
    28261 atcatcttta tatccttctt ctgcaagtcc atcttggatc cctttataaa tcaaatcaag
    28321 ggatggatgg ctcacaaatt gaagcacacc aatcttggtt attttcttct catccttatt
    28381 attctgaact tctgatttat tcattgaaga ataaatcaag cttcctgcta ctaagactgc
    28441 taatgcagca ataattccaa ttaaacgttt atttttcatt ctgtttctcc tttttatttc
    28501 ctttaacata tttcacttat ctaaacaagc gacgccatcg ttttctttcc atactaacct
    28561 ccatcaaaaa aatcctcaca caaaaaactt gtgtgaggac gtcgatgcgc ggtaccacct
    28621 caattatagg gaatttccct atcgctcagt ctcgcaataa cgagatgcac tgtaaggtgt
    28681 gcttaccgaa tttttataat ttcaaattct aaatagcatt cagcccaatt ttcatcattg
    28741 ccacttatct gttttcagct accacagact ctctaaaaag tttgtatgat tacttttctg
    28801 aatggttaaa ttatatcatt tttaaactac ttgtcaatag tctattagaa tttttttgat
    28861 attcactttt agcattcact cttgaaaatt atcaacctga attacgcaat cctgtcgcaa
    28921 ttccgttgat ggtgatatga atcaatcgtt cttgatcact ggacaattct ccacgacgtt
    28981 ggcgtttaat caactctaac tgaatatagt tgagaatatt aaagtaaggc atacggtaat
    29041 ccagactagc ttttagatat ggattgtcag ctaagagttc gtcatgtcct tcaatagcca
    29101 agataacgtt cttagtaact tgccattcat ttaaaatagt ctcatagatg gccttaactt
    29161 gctcgtcttc acaaagttta gcatattcaa aagcaatatt catatttgat tttgacaaaa
    29221 ccatatcaac atttgaaaga agcgattgga agaaaggcca attttggtac atatctcgta
    29281 agatagcaat attctctgga tttttattga taaattcctt gaagcttgaa ccaaccccgt
    29341 accatccagg gaacataaca cgactctgtg accatgagaa tacccaaggg atggcacgca
    29401 aaccaccgat ttcagtaata gtcttacgag cggctggacg agaaccaata ttaaaacttg
    29461 aaatagcctt gattggactt gactcgaaga aataatcata gaaatgctca ttaccaaaga
    29521 ccaaatcacg gtagatatcg taactacggt ccactacttg atccataatg gcttcataac
    29581 gatttggggt attggtatcg ctcttcttct gagtaatcat acggttaata gctgccgata
    29641 ctagcatttc aaggttatag taagcggcgt ctttgttacc gtatttattc ccaattactt
    29701 caccctgctc cgtcaagcgg atacgatcct tgatagactt gagcggttga gatgtaatgg
    29761 cttcataggt tggcccacca ccacgaccga cagtaccacc acgaccatgg aagaaggtaa
    29821 ccttaacgcc aaattcatct ccaatagcag tcaattgttg ttgagccttg tagagggtcc
    29881 aacatgatga caagtaaccg ccatctttat tactgtcaga gtagccaagc atgatttctt
    29941 ggtagttatt tcgtgagtca atccattttt tggcaaggct aagagaaaga tattttctca
    30001 ttgtttcctc tgaatgatcc aagtcttcaa ttgtttcaaa aaggggaaca atctgaacac
    30061 gcgccctttc cgtatccacc agtcctactt cttttaacag aatagctaat tctagcatat
    30121 cagaaaggct ggttgcatgt gaaatgatgg tctgacggat gacatcatct cccaacttat
    30181 ctttcaaaac acgagccgtc ttaaaaatag ctaattcttt tgctaataat tctgattttt
    30241 ctgcgtgagt cgcagaaaga attcggggat cttcttctaa ttctttcaag agaaggtcac
    30301 acttttcttc ttcgctcaac tcgctataac gagaatgaat tcctgctgat ttcaagagtt
    30361 ctgccacaca ggcttcatag acgctagagt cttgtcgcat atcaattgat gctaagtaaa
    30421 aaccaaatat ctctactgcc tgcaataatt ccacaaaatc acctgaaatc aaggactcgc
    30481 ccttattttc tagtagagaa tctcgaatgg caatcaaatc cttgtagaaa tcattggcgg
    30541 tttcataacg agtcccaact tcttcatcct caatcagata ggttttagtt gcctgaattt
    30601 ttgattgaat atcaaacaag gcacgacggt aaagctcttt ttcgcggtaa atcgagttat
    30661 ccttggattg acgagccatt tctctgactt gcttgctgac gttgacaatg ctagttgaaa
    30721 gagaaaattc acgataaagt tggtaaatct ttttatcata gtagttcatg atgacttcac
    30781 actgagtgag tgcagactgc ttcaaggtct ttgctgtaac aaatggattt ccatcacggt
    30841 caccacctat ccacataccc atggtgattg gtttagcctg ttttaaattc agaccatgcg
    30901 cttgcgctaa gcgcttatac tccgtcgtca aatgaggtac agctttcaaa aaggagctgt
    30961 tataatattc catagcattc gtgatttcgt tagtcacttt taattttttc tcacgaatca
    31021 tgtctgtctg catgataatt tcgatgtaac gacgcaaatc attgtaccat ttatctttat
    31081 tgatcaaccc caacttaaca tcacggtatt tacgcaaaag actatgaata tgatttgtta
    31141 aatccaacat acttttgcgt tgcacttgtg ttggatgggc tgtcaaaaca gggacaacat
    31201 tcaagtgttc taggatctca acggcatttt ccttttctgc taccaattta atcgttgtag
    31261 ataatttacc taaatagtcc tgatcaatat tattttgatg attgatttca taagctaaat
    31321 ccacatcctc tgaaatatta atcaaaagag gcaagataga gaaatagcgt gaaatataga
    31381 ccatttcatc atttgataag ctagtcacta gacggtttag accttgataa tcttcctgcg
    31441 ttgataattc tttcaactgt attatttttt caaaggtctc tggggcaagc atatttttag
    31501 taatatcttc cagtaattct gttagaatca agacttcttc ttgcacaaca cttttattac
    31561 tataattttc taatttttga agagacataa actatccttt ctttatccta cttcaacaga
    31621 aggttcattg gttgattttc caattctcgg tacaatttag cgcgtttttc actggcatca
    31681 atatttaaga caaaggctac tgccactgat aagactagaa gactatttcc accctgggat
    31741 aagaagggga aagtcactcc tgtagatgga atcaagcccg aaatccctcc gatattgaca
    31801 aatacctgaa ccaacatcat ccctccgaca ccgagtgcaa ccatggcatt gaaaggattc
    31861 tccgctcgga taccgaccaa gataatccgc aaaatcatga aaaacaagag agctaaaata
    31921 agactggcac caacaaagcc aaattcttca atcacgatag aaaagacaaa gtctgtatga
    31981 gcttctggca aataacctcg tttttcaatc gagtttccaa gacctagacc aaaccaaccg
    32041 ccattgacca tggcaaaata agaattagct aactggtgac ctgcatcagc acgatcggca
    32101 aaaggattaa aaaaggcact aaagcgcttg gctacatagc cgaatactgg aatttttgaa
    32161 aaggtctcaa caccgattag gctgatagtg gtcaagacaa agacagaagc ggcagatacg
    32221 agcgccagaa tggttgaaaa ccagcgataa gcgattccac taactgtata cataatcaag
    32281 gaaaccaaga ctaaaatagt cgcatttcct aaatcaggga aaattcccaa acttccaatc
    32341 agaactagga gaacgaatcg ccaatcatta aaagcacggg gaagccattg attttgagtc
    32401 aaaacttgaa aatcataagt agctatttct tcttgctgtt tggagaatcg gtgagctaaa
    32461 taccaaataa taatgatttt taagtactca gctggctgaa tagttactcc tgcaaccgaa
    32521 atccaaccgt atgccccgtt tacggaaaga ccaataaaac gagccaagaa caatagaagc
    32581 atttctatta atataactaa aatgattagt cgctcatttc tcaaaaaatc tagtctcaat
    32641 ttataaatta aggcaatcag tatcaaacta acaatccaaa agattccttg gtttcgaacc
    32701 aactgcaagg cactcttgcc ttcttcaatt aaaatagcac tggtggtcga atagaccaca
    32761 atcaagccca aaatagataa aagcaagtag ggaatcaaga tggaataatt taataagtgc
    32821 ctcttactaa tcttcatagc atcaccactc tactaggata cagacaaatc tgttccaaat
    32881 tccgttttat tttctagttt tgattgctat tataccattt tttcagaaag aaaaaaactc
    32941 ttaccttata atccttcgaa ttttactgtt tttcataatt agagcagaat ttgaaatcgt
    33001 aaaaccattt tgaacaagag ttacttcaac ccattgactc cgacggatta agttgctttc
    33061 gtgaatgcca aaatcagccg aaatttgttc ataagtgcgc tattctcgca tgtattgaat
    33121 agttaccata aggagatcgt ctaggcttaa tttggttttt cgtccacctt ttgcgcgttt
    33181 acgttgataa gctgttttta acacagctaa catctcttca aaagtcgtgc gctgaacacc
    33241 tacaaggatc ttgaaacggc tatcgctcaa ttgtttactt gcttcatcat ccatagtttt
    33301 attgtattgt atttttgttt cgcaggaagt ctattattcc tttcgttcca aggtttttac
    33361 gcttttagca acaagcttac acactgagcg tttcggactt accatatcat ttcgttggag
    33421 attttatcat caatttttag attaaaaaag atttcccaat cttcacaaac ttctgtagca
    33481 ggaattgtat gaatctttct aagtatcttt cctgcttcta caccatatgt gtattgttgg
    33541 ttttatgaat aagttaaaat gctatctatt gcatctcttc cgtctatcca ttcgtgtaaa
    33601 gaatgtactt cgtcatcgca gagttcaatg ctaattggtt tacacatcgg aactccaaga
    33661 gaagctactt tctccatcgt atcaaattca atttttttat aatctaactt cgacttatca
    33721 gaaacacgca agaaatatgt ttactgattt tgaactgtca cacaatattt tttatcatct
    33781 gaccagcctt tatttatggc tatcttacta ctaaaatcca tcaagcacac tccgattcac
    33841 tttacaacac tttttgcagt tttcactagt aacctatcca gttcgtctac acttttattt
    33901 cctagatcca tttttacatt atgaaagtta gtcaattttc tctatgatgt ttccaagttt
    33961 atccaataca agacaagaat gatcatttag tggaattatg ggaacattaa cgagttcttc
    34021 agctctatcc ttatttgctt tatcattcca ggaatcataa tggacactaa ttaaaaactg
    34081 actaaaaagt cctaatccat tttttatctt tatctgataa tctgaattaa cattaggtga
    34141 gacatagact ttttctccta atagtagggc tcctgcagaa aatcctataa tttttgcctc
    34201 tttattaagc atatgatcga tataactttt gaactcctga ttaacataag tagcaatata
    34261 tttttccgta tttccaccac cgatgataat tatgtcagca tctagatagc tatcaagatc
    34321 aatctgctca gtgtccagga gcaagtaatc aatgtttaga ttaggaaatt gactttgaaa
    34381 aacttccgtg tactttttca tgtacggttc ccaattttct cgaaaaactg taaaaatgac
    34441 aattctttcg atcttccttg atgacacaat tttattaaca atcgtatagt tctttatcgg
    34501 cggattccca cccatcaaaa aaatttgttc tttcaagtta tcacactttc taaagataca
    34561 taaagtttaa acaagtttat tcacgtttcg aaattataat ttttttaaaa catatcattt
    34621 tattgactgg ctaagatcga accagcaaca ctacacactc cacgtgtgtt gtctgttcct
    34681 tgagaataca attttttatc ctcgtcactg ttttgaggac acaatttatc tgtttctagt
    34741 ttagcatttt tacgtttact tttaaattgt ttaccatcct tgttttgaat ttcacctgtt
    34801 ttgaatatta tggttaacat tgcaggatca atttctccgt tgctattaac tccacctaca
    34861 ataattttct caacaatact ttcaaaaact gcacgatcaa actccgtaag cattttttgc
    34921 gaagatagca agtgcttaaa ctcagttagt cttttcttta catcgatttc tgattttaat
    34981 gttgtttcaa tatttacctt ctcttctgct agaaactctt tttctgagga aatttcattg
    35041 tacttttcat tgtatatgga atcgctaact tttccttcga gccttagatt tacaagattc
    35101 tcctcttttt ttagtaatat tcgaagtttg tttgtaatcc tttttagttc cttgttaagg
    35161 ctattgtcat tcaattcaga ttctatcgtt tcaagtaagt ctgtcattaa attttcattt
    35221 gaatgataga cttgtctgta agcttccagg aaagccccct caatggcgat ctcttctaat
    35281 cctttactat gcttacaaaa tttctttcct ttctttatcg atgtaacaca gtgccacaca
    35341 actttgcgat aatctgaacg gcagtgccaa cttcttctag ataatattga accacaaaaa
    35401 ccacattcca acatgctact aaaagcatac atttttgaat agcgttcacg cttcccattt
    35461 acattcgcag ctgtcttctt atttcctgct cgacgcaatc taatctcctg agctttttca
    35521 aaatcttctt tagatattat tggttcatga ttatccttga tatagtactt atcttcttct
    35581 ccaaaattac tcaaccgtct cttgcttatt gggtcaactg taaaagtttt tcccattaga
    35641 atatcacctt tatatttttc attctttatt attcctagaa ctgttgtatc attccagtgt
    35701 tctaaacctc ttggcgattt gtaaccaagt tcatcaagtt cccttgcaat tacttttcct
    35761 ccaatacctt ctagatacct ttcaaaaata taacgaacaa ttttggcttc ttttttatta
    35821 attgaaatct gcttggtttc tacatcataa tcatacccta agcacccttg aaaaccaacc
    35881 aattcaccac gttgcatctt catttttaat ccttttttca catgggcaga agtattctct
    35941 acttcttgct gtgcaacgga gcttagaata gttagaagca attctccatc cattgttagg
    36001 gtatctatgt tttcttcctc aaaatatact ccaatttgca tatcctttaa cattctgaca
    36061 tacttcaaag tatctagggt attccttgca aatctagcaa ttgcttttgt gacaatataa
    36121 tctatctctc catttgcaca atcattgatt aatcgttgaa aatcttgtct ctttcctact
    36181 tgtgttcctg aaataccttc atctgcataa atatctgcca gctcccaatc tgaacgctga
    36241 gaaatatatt ctttgtagtg tcttacttga gaatcataac tgtttttctg atcctcacta
    36301 tcggaactaa ctctgcaata agcagcaacc ctctttaagt gtctttctac attgtcgcct
    36361 cttcgacgaa ctaaagaatc agcttttatt atttcaacat tatttttttt catactgaaa
    36421 ttcctccttt tgattctata ttaccgcatt caaatcaaaa agtcagctat tttgtgtact
    36481 taatacgcag tttgtttcta atcttgtcat actcattttt agataacata tttcttgagt
    36541 ataaaaagtt aagcattgat agttgcatag tatactttat tactgattgt tccaaacttt
    36601 ttcctccttg taacatgtat aatttcctcc gtgggtatga ctggttaaat cattcatggg
    36661 catttcaccc gctgtccttt ttcgctggca gcctgaacgt tcagaagtat cattatcctt
    36721 atttgtagtc atggcagata gagaaccact ctattttata gctaataatt atcgctccta
    36781 tcacggcgta tcaagctaaa gtgctcgaca aataagaaag tcccacctcg gtttattcag
    36841 ttttcaaagg gcttaggatt tattaacaac taaacttatc catctctaaa atataatctg
    36901 tagttacctg atataattta gctaattgtt tcaaaaatga tgtaggaata tcttgcttgc
    36961 cactttctat tctagaataa gcagactgtg aacaatgaag atactgtgca atttgacact
    37021 gggacaaatc tttgtcttct cttaaattct ttaatctgat atacattaat aatcctctta
    37081 ctaatattgt aatttgaaga ttatcaaatt tggaatttta tgcaaaatat gcataaaata
    37141 atttataaga ttttagaaat agttggtata acagtaagta agctataagt tactaaaaaa
    37201 agattttgga ataaactttt tcatagcgat aaaagcaccg tacaagctag gaaaataata
    37261 agtaatcgcc caatctgacc ttctccagaa cttgattatt cgtcaatcac tacagttgac
    37321 aaacatacta agattagtag tgaggaaatc tccaacggga gagagtactc attacttttt
    37381 ctttgtgtta aaatagtggt gtcttgttaa gtcatagagc tctctatggt gctagacgtc
    37441 gcttgacaaa ctggcaagaa acctgtttta ggaagaattt tatcaaagta tgtgggatac
    37501 tagacgtcga gtattggaaa taaaatcact aaaacaagga gtcattcaag acaaaggggt
    37561 aaacatgatg cggacagttt tcagaatgga tgtgagtaag gcaagctcag aagtcgctat
    37621 tcttgtgaat ggtgaaaagg ttcatggcta taccatgccc aatgatgcca tcggatttag
    37681 tcgtcttcta gaggatttga aataggtaaa tacacctgag attatcttcg aggcacaggg
    37741 gtctattctc gtcttcaggc ctttctggag gacaatagct atgcttatat acggctaaat
    37801 cctttaaaac taagaagcaa ctagacagtt tgcgagtccg taaaaccaat cagattgacg
    37861 ctgaaaagct agcttcgtca caattcatcc ttaaccgcaa accaacttat gttcaagaag
    37921 aagtctatca aaatttgcgt gacctcagtc gattctatca gaatctgaca gaagacatcg
    37981 ttaggactaa gaatagcctg cacaaggtgc ttcaaattgc ctttccagaa ataaagaacc
    38041 ttctctctac tcctacaggg gaacaatatt ggaacctcgt gaccatcttt ccaaccaagc
    38101 attggaggct gaaattatca gtagttgagc taaaagaagc catcgtaatt caacttctaa
    38161 acggatttct gagaacagag ttggacgatt ggctgaaaag ttgagcgagc tggccgaaca
    38221 gtcctatctt gccatttcaa aaacctctcc catgacagaa gaggttaagt atcatgcaca
    38281 ggaactgttg agactgacaa accgcaagga tcaggactta gcacaaatga ttgaattggc
    38341 tgaaccatta cctgaatacg agattctgct ctctattcct ggtatcgcag aaacaacagc
    38401 tacaagcatt attggcgaat tggagacatt cgtcgctttc agtctgccaa ccaaatcaat
    38461 gcctttatca gtattgacct cagacactat gaatctggca atttcctagc tcaagaacat
    38521 atcaccaagc gtggaaatcc ttacgcgaga aaaattctct ataagtgcgt ccacaatatt
    38581 gcttcagcta gtcataccaa tccttgtcat atcgcggact tttatgagaa acgaaaaaga
    38641 caatcgcaga cgacttcaac caagccatat acgattgtct ctatacatcg cctcatccgg
    38701 acaatgtatt acctcataac gcataacaaa ctttacgact acactttaac ccaaagtcat
    38761 taaagtcatc tatgtcctat cattgtaaca ccttattttt taataccaga taagtgtctt
    38821 ttaagtgtgc ccaaatttca aaaaacagct cgcaattatc ttctaaacat tcctttgata
    38881 ctcattcaga aaaccttttg agctagaata tcgtatgtcc cttaacaaat ggtatgtata
    38941 aaagagctaa aaaaccactc atgatatgaa cgagtggtta tgactgaaat attacatacc
    39001 tttgtatcat ttttgcacaa tggtcaaatt tcttgtttga aaaactacag taagcctaat
    39061 caaagctctc aatgtatcat taaaacttcc ttccaaagaa taggaagttc tatcaaaatt
    39121 cttaattaga ttttacttct tctaagaccc tgcgctctca tatgcatcca aacctttgtt
    39181 ccataatttt aatgataagg taaaaaatat taatgagata aggatcaatc caccaatatt
    39241 gaacaatcca tccttgtctt tcaagaaata gctagctggg taataggctg taaaagcaaa
    39301 aggaatgata aaactaatca accaacgtaa aaacgaatgg taaatcgcaa tcgggtattt
    39361 tgcaaaatca ttaaacatgt aaaaaatata aattattgcc ccagattgtt tagtccaaaa
    39421 agcaatacta gctgttacaa tttttaaaga ggtataaatt aaggttgcaa agggaatact
    39481 gattaaaaag agaaaaacct ttgcccaagt ccaagtaaga ctagttattg tcattaacag
    39541 caataagacg cctactaaca attctccaag agcatcaatt tgaaacgttt ctactaaaat
    39601 atgaaacaaa gggctaatgg gtctagtcaa atacttatca aattctcctt tacgaattaa
    39661 atgttgtcct aaagctcaca gattatcaaa aaagagatgg tcaattccct taggaatgag
    39721 agaaaaacca taaataaaag caacctgatg aaaactccag ccatcaagta agggaatatg
    39781 ttgaaacaaa atatttagaa acagcatgtt taacccttgt gtcaaaaaga cacccacaac
    39841 accaactaaa aaatcagcct tatactccat aatctgttta agatattgtc ggataaaaat
    39901 caggtgcatg cgttgatatt tcttcattct aacctccttg aatagttata taattctgta
    39961 cgcacttcca aatcagttgg gataaggcaa tcataataaa cagccagaat aattgtagcg
    40021 agagcgcctg aatcatttga ctcatgctat acttttctat aataaccatc accggggtat
    40081 agattaaaga agaaaatggc aaaaaagata atagttcggc aataattttt ggaaaaaatg
    40141 tcagaggaac caaacttcca gataaaaagg caactaaaga atttttcaaa agatttgatc
    40201 cccataagtt tttaaacaca aaagctgaaa aaccaaagca aatattgaaa aaaaaaatta
    40261 atcaaaaaag ctaagattaa gctaagaagg taaactgtgg ttattaaaac aatttgtaag
    40321 aaggactcac ctgataagag ctttagacct gcaatcagaa ttacaaatgg tagaccaaca
    40381 ctaacaaaaa ctagccatct agacccaatt tctgtgaaaa gataagacat tgcaaaatga
    40441 actggacgaa gcagtcgcat aataatagag ccatccttta cttcccatcc aatcataaaa
    40501 gaactatctg attttgtcag tagattcgtc acaaaactca tgatgatata taaggtcata
    40561 tcagataaag taaaaccttg aatgagagac tggtgagatg aatcaaacac agctttccac
    40621 aagtaaaatg ctacaaaggc ccccatcaca tccccaatgc gataaagaaa aaaattgaca
    40681 cgatacgtga ttaattcttg gattccagcg ctaacaaaag gcttatagcg tttccataat
    40741 ttagtcatcc taaagctcct ttcgatagaa gcgacgaata atatcttcaa tattcgcatc
    40801 cgtcatcttt aaatcacgga tcgtaaaatc agacaaagtt tgttgaataa tgtcagccgt
    40861 ttgatactgc gagctgtcgt actgaatatc aagtgacaat tcctgtctcg tcacatagat
    40921 atcagaaagt ccttcaaaat gagagacaat ataatcctgc ccaggatgta gttcaaaaga
    40981 gagagtcttc atcttcccga aagtcttttt cagttgattc acagttccat caaagatttc
    41041 tcggccctta tcaatcataa aaatacgatc acataactgt tcaatatcac ctaaatcgtg
    41101 ggtcgttaaa agtatggtcg tctcttcttc ttgattaatc tgtgtaatgg cacgtcgaat
    41161 attatccttg accgaaacat ctaaaccaat agtaggctca tctaggaaaa gaactttcgg
    41221 attatgcaat aaggaggccg caatatccgc cctcatacgt tgacctagag atagagttct
    41281 gacaggatct tgaataaatt ccttcaaatc taaaacttca tttagaaaat ccatgcgttt
    41341 ttgaaagacc gcatcaggaa catcataaat ttcctttaaa accgagtaag tctcctgcaa
    41401 agccaaatcc caccaaagtt gagttcgctg cccaaaaact acaccaatat ctttaacata
    41461 gccttgacgg ttctcttgag gaatctttcc attgatacga caaaaacctg atgttggttt
    41521 caaaatcccc gtcaacatct tgatagttgt tgatttcccc gctccatttg cgccaataaa
    41581 gcctaaaatt tgtcctttgg gcacctcaaa tgataaatct ttaacagctt caaagacttg
    41641 tctcttggga tgaaaaaaag agcgaaaagc tccctttaag ccaggttcct ttattgtttt
    41701 cacaaaattt ttctgaagat gctctactgt tatcattttt ataaatcact cctttcgttt
    41761 cactcaagtt ataatatcaa caaaaattgt agcatactac agtaaagtta agaaaattta
    41821 ccatcattac aaaccatatg aaaaaagcta ctaaaactat gccatcttgt attttatctg
    41881 taagtaagct aaattactca agtacaaaga attatgacga agaacatata aatttataat
    41941 tggataaact atagatttca gcaaacgaag ttatcccaat ataaaaatac tttaataact
    42001 gaagatattg acaggaagat attaaattcc tcattactat cctttactat gcagtataat
    42061 tttaatatca tttacctact tccaagatgc tgaaaaatac taagtcacac tattatgatg
    42121 ttattatttc catttttatt ttaacagatg agtcaattct ttcaactacc ccctccctta
    42181 taactatatt catgaagtat tcttgataat aaacctcatt taacttctca aagtagtcag
    42241 cttctgcaac tgctattatc tcataacaga ttgatttggt ttcaataaat ggaagctaga
    42301 agccttgtca gctaccctgc acagttggtg ttttttcatt tttctcttca aaaaaattgg
    42361 tcggaagtta taataaaaag gtgatgtgtt tgtggtgagt tgaattaaga gacaaactca
    42421 ctttgtctta acttttaaat tgcctaacaa aaatacggag attattctct aagctttaac
    42481 tgcaacatta tgtctctaca accaacgata agtccagaaa tctacccaaa taaccaaaca
    42541 acctacattt gttgaacttt gatgacaagt aggaaatttt acatttgata aacactattt
    42601 tgtacgcatt ttgcacataa tttaacgtgc tttccatcaa tttagttaag gacttacata
    42661 gaaaacaatc cgtttttgct tatgttaaat tagtagaatt agacaaaaac aaaaccgccg
    42721 ttcgcactgt tatatattca tttttagtac ttactattct aaaaaagata tctatctttc
    42781 aattcctcaa tttcttgac
//
LOCUS       DAVLHC010000016        39822 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.016, whole genome shotgun sequence.
ACCESSION   DAVLHC010000016 DAVLHC010000000
VERSION     DAVLHC010000016.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 39822)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 39822)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..39822
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.016"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(56..964)
                     /locus_tag="VXE25_000917"
     CDS             complement(56..964)
                     /locus_tag="VXE25_000917"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HEV0771399.1"
                     /translation="MRIQQLHYIIKIVETGSMNEAAKQLFITQPSLSNAVRDLENEMG
                     IEIFIRNPKGITLTRDGMEFLSYARQVVEQTQLLEERYKNPVAHRELFSVSSQHYAFV
                     VNAFVSLLKKSDMEKYELFLRETRTWEIIDDVKNFRSEVGVLFLNSYNRDVLTKMLDD
                     NHLLAHHLFTAQPHIFVSKTNPLAKKDKVKLSDLENFPYLSYDQGTHNSFYFSEEILS
                     QEHHKKSIVVSDRATLFNLLIGLDGYTIATGILNSNLNGDNIVSIPLDIDDPIELVYI
                     QHEKTSLSKMGERFIDYLLEEVQFDS"
     gene            1028..1297
                     /locus_tag="VXE25_000918"
     CDS             1028..1297
                     /locus_tag="VXE25_000918"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000051789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YqgQ family protein"
                     /protein_id="HEV0771400.1"
                     /translation="MSLFLKKTQNFARMSLMKTFYDVQQFLKRFGIIVYMGKRLYDIE
                     LMKLELSRIYDAGLMDKLDYLEAEAVLRREHKVELDYIEKNGEKN"
     gene            1297..1677
                     /locus_tag="VXE25_000919"
     CDS             1297..1677
                     /locus_tag="VXE25_000919"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="HEV0771401.1"
                     /translation="MVTWILWALILAMLAWMGFNYLRIRRAAKIVDNEEFEALIRTGQ
                     LIDLRDPAEFHRKHILGARNIPSSQLKTSLAALRKDKPVLLYENQRAQRVTNAALYLK
                     KQGFSEIYILSYGLDSWKGKVKTS"
     gene            1766..1993
                     /locus_tag="VXE25_000920"
     CDS             1766..1993
                     /locus_tag="VXE25_000920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000660075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771402.1"
                     /translation="MKEKKKNPLFVGILSIILGLLFPIVGLILGIIGLVLAISYQKES
                     QLDYKIEKILNILGIVISVVNWIVAIALIFR"
     gene            complement(2033..2758)
                     /locus_tag="VXE25_000921"
     CDS             complement(2033..2758)
                     /locus_tag="VXE25_000921"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001235004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA pseudouridine(516) synthase"
                     /protein_id="HEV0771403.1"
                     /translation="MRLDNLLAQEKVSRKAMKQALLRGEILVDGCPARSLAQNIDTGL
                     QELLFQDRIIQGYEHTYLMLHKPAGVVTANKDKELPTVMDLLPSDIQSDKLYAVGRLD
                     RDTTGLLLLTDNGPLGFQLLHPQYHVDKTYQVEVNGLLTPDHIQAFQKGIVFLDGTVC
                     KPAKLEILSASPSLSQASITISEGKFHQIKKMFLSVGVKVTSLKRIQFGDFTLNPDLA
                     EGNYRPLNQKELQIIKNYLEMSR"
     gene            2920..4761
                     /gene="typA"
                     /locus_tag="VXE25_000922"
     CDS             2920..4761
                     /gene="typA"
                     /locus_tag="VXE25_000922"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003078415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translational GTPase TypA"
                     /protein_id="HEV0771404.1"
                     /translation="MTKLREDIRNIAIIAHVDHGKTTLVDELLKQSETLDARTELAER
                     AMDSNDIEKERGITILAKNTAVAYNGTRINIMDTPGHADFGGEVERIMKMVDGVVLVV
                     DAYEGTMPQTRFVLKKALEQDLVPIVVVNKIDKPSARPAEVVDEVLELFIELGADDDQ
                     LDFPVVYASAINGTSSLSDDPADQEATMAPIFDTIIDHIPAPVDNSDEPLQFQVSLLD
                     YNDFVGRIGIGRVFRGTVKVGDQVTLSKLDGTTKNFRVTKLFGFFGLERREIQEAKAG
                     DLIAVSGMEDIFVGETITPTDAVEALPILHIDEPTLQMTFLVNNSPFAGKEGKWVTSR
                     KVEERLQAELQTDVSLRVDPTDSPDKWTVSGRGELHLSILIETMRREGYELQVSRPEV
                     IVKEIDGVKCEPFERVQIDTPEEYQGSVIQSLSERKGEMLDMISTGNGQTRLVFLVPA
                     RGLIGYSTEFLSMTRGYGIMNHTFDQYLPLIPGEIGGRHRGALVSIDAGKATTYSIMS
                     IEERGTIFVNPGTEVYEGMIIGENSRENDLTVNITKAKQMTNVRSATKDQTAVIKTPR
                     ILTLEESLEFLNDDEYMEVTPESIRLRKQILNKAEREKANKKKKSAE"
     gene            4781..5035
                     /locus_tag="VXE25_000923"
     CDS             4781..5035
                     /locus_tag="VXE25_000923"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000262800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3165 family protein"
                     /protein_id="HEV0771405.1"
                     /translation="MVYLVLGILLLLLYVFATPESIKGTVNIVAMVCILVALLILLVL
                     SFLKIFQLPTEIFLAIAMLILAYFSVRDITLMPVKKSKRR"
     gene            5399..5698
                     /locus_tag="VXE25_000924"
     CDS             5399..5698
                     /locus_tag="VXE25_000924"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="HEV0771406.1"
                     /translation="MKTKKHRLLALALISSFTLLGAASAAVQYPDGGVWTYGEGSGGG
                     WAFSNYYHGKKYHYSSLVSRWNSHSDKGEASAGKTSYAWIWTKWGEQVAFYCDYD"
     gene            5769..7790
                     /locus_tag="VXE25_000925"
     CDS             5769..7790
                     /locus_tag="VXE25_000925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000732428.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="HEV0771407.1"
                     /translation="MKKLFILLSTFFLSFFLAWIIVLRAPQYLYASYDSVSLLRVKKD
                     TQEPTREVFEQELENFANSEQSLIARRIVEPSKDGTTHFTYATYGQGTLPKEFQEASQ
                     ESRERSDPLNSYLLLSGSLTKEKLADKLGDLGYKASADRKIPPYFLAFRILLNPLILI
                     SLAIFGLSFFALVIITRIKEMRAAGIKLFSGQTLLSIMGHSLSTDIKWLLLSALLSFL
                     GGGVVLFSQGLFYPILLATYGFGISFYLLFLLAISILLMLLYLMSLSYKALVPVIKGR
                     LPLKRLMILTLLCQLVAVFTVGYAVKTGLMSYQRLKELEISKQAWQDRADYYQISFGL
                     GDRGKDTENQSKWYAFAKEAIEEEQALYVKDNLLHFANPQGKNEQGETLDTYSPDANT
                     LYVSPSYLDKEKVVVDAETKQKLAHLQKGEFILLLPEHLRSREAELKKVFEERLSYYG
                     KSGEEASAPLDYEMKAHVSYLSMGEKRFVYNNGENPVSTQYLTDPILVVFTPTSTGDS
                     FISLSSWSINAGKQLFIKGYESGLELLKKAGIYEQVSYLKEGRSVYLTRYNEVQTETA
                     TLILGAIVGIASSLLLFYSVNLLYFEQFRRDILIKRISGLRFFETHAQYMVSQFASFV
                     FGASLFILSSRDLVIGLLTLLVFLASAVLTLYRQAQKESRVSMTIMKGK"
     gene            7792..8433
                     /locus_tag="VXE25_000926"
     CDS             7792..8433
                     /locus_tag="VXE25_000926"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000571297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0771408.1"
                     /translation="MIELKNISKKFGSRQLFSDTNLHFEGGKIYALIGTSGCGKTTLL
                     NMIGRLEPYDKGQIIYDGTSLKDIKPSVFFRDYLGYLFQDFGLIESQTVKENLNLSLV
                     GKKLKEKEKISLMKQALNCVNLSYLDLKQPIFELSGGEAQRVALAKIILKDPPLILAD
                     EPTASLDPKNSEELLSILESLKNPNRTIIIATHNPLIWEQVDQVIRVTDLSHR"
     gene            8537..9889
                     /locus_tag="VXE25_000927"
     CDS             8537..9889
                     /locus_tag="VXE25_000927"
                     /EC_number="6.3.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000862950.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-L-alanine--D-glutamate
                     ligase"
                     /protein_id="HEV0771409.1"
                     /translation="MKVIDQFKNKKVLVLGLAKSGESAARLLDKLGAIVTVNDGKPFE
                     DNPAAQCLLEEGIKVITGGHPLELLDEEFALMVKNPGIPYNNPMIEKALAKGIPVLTE
                     VELAYLISEAPIIGITGSNGKTTTTTMIGEVLTAAGQHGLLSGNIGYPASQVAQTASD
                     KDTLVMELSSFQLMGVQEFHPEIAVITNLMPTHIDYHGSFSEYVAAKWNIQNKMTAAD
                     FLVLNFNQDLAKDLTSKTEATVVAFSTLEKVDGAYLEDGQLYFRGEVVMAANEIGVPG
                     SHNVENALATIAVAKLRDVDNQTIKETLSAFGGVKHRLQFVDDIKGVKFYNDSKSTNI
                     LATQKALSGFDNSKVVLIAGGLDRGNEFDELVPDITGLKKMVILGQSAERVKRAADKA
                     GVAYVEATDIADATRKAYELATQGDVVLLSPANASWDMYANFEVRGDLFIDTVAELKE
                     "
     gene            9893..10951
                     /locus_tag="VXE25_000928"
     CDS             9893..10951
                     /locus_tag="VXE25_000928"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000724845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine--N-acetylmuramyl-
                     (pentapeptide) pyrophosphoryl-undecaprenol
                     N-acetylglucosamine transferase"
                     /protein_id="HEV0771410.1"
                     /translation="MKKIVFTGGGTVGHVTLNLLLMPKFIEDGWEVHYIGNKRGIEHQ
                     EILKSGLDVTFHSIATGKLRRYFSWQNMLDVFKVGWGIVQSLFIMLRLRPQTLFSKGG
                     FVSVPPVIAARVSGVPVFIHESDLSMGLANKIAYKFATKMYSTFEQASSLAKVEHVGA
                     VTKVSDKNTPEPDELVDIQTHFNPKLPTVLFVGGSAGARVFNQLVTDHKKELTERYNI
                     INLTGDSSLNELRQNLFRVDYVTDLYQPLMELADIVVTRGGANTIFELLAIAKLHVIV
                     PLGREASRGDQIENAAYFVKKGYAEDLQESDLTLDSLEEKLSHLLSHKEDYQAKMKAS
                     KELKSLADFYQLLKKDLS"
     gene            10961..12127
                     /gene="divIB"
                     /locus_tag="VXE25_000929"
     CDS             10961..12127
                     /gene="divIB"
                     /locus_tag="VXE25_000929"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000031166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein DivIB"
                     /protein_id="HEV0771411.1"
                     /translation="MSKDKKNEDKETLEELKELSEWQKRNQEYLKKKAEEEAALAEEK
                     EKERQARMGEESEKSEDKQDQESETDQEDSESAKEESEEKVASSEADKEKEEKEEPES
                     KEKEEQDKKLSKKATKEKPAKAKIPGIHILRAFTILFPSLLLLIVSAYLLSPYATMKD
                     IRVEGTVQTTADDIRQASGIQDSDYTINLLLDKAKYEKQIKSNYWVESAQLVYQFPTK
                     FTIKVKEYDIVAYYISGENHYPILSSGQLETSSVSLNSLPETYLSVLFNDSEQIKVFV
                     SELAQISPELKAAIQKVELAPSKVTSDLIRLTMNDSDEVLVPLSEMSKKLPYYSKIKP
                     QLSEPSVVDMEAGIYSYTVADKLIMEAEEKAKQEAKEAEKKQEEEQKKQEEESN"
     gene            12393..13094
                     /gene="pyrF"
                     /locus_tag="VXE25_000930"
     CDS             12393..13094
                     /gene="pyrF"
                     /locus_tag="VXE25_000930"
                     /EC_number="4.1.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001206708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="orotidine-5'-phosphate decarboxylase"
                     /protein_id="HEV0771412.1"
                     /translation="MREHRPIIALDFPSFEAVKEFLALFPAEESLYLKVGMELYYAAG
                     PEIVSYLKGLGHSVFLDLKLHDIPNTVKSAMKILSQLGVDMTNVHAAGGVEMMKAARE
                     GLGSQAKLIAVTQLTSTSEAQMQEFQNIQTSLQESVIHYAKKTAEAGLDGVVCSAQEV
                     QVIKQATNPDFICLTPGIRPAGVAVGDQKRVMTPADAYQIGSDYIVVGRPIIQAEDPV
                     AAYHTIKDEWTQDWN"
     gene            13128..13760
                     /locus_tag="VXE25_000931"
     CDS             13128..13760
                     /locus_tag="VXE25_000931"
                     /EC_number="2.4.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000170913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="orotate phosphoribosyltransferase"
                     /protein_id="HEV0771413.1"
                     /translation="MTLAKDIASHLLKIQAVYLKPEEPFTWASGIKSPIYTDNRVTLA
                     YPETRTLIENGFVDAIKEAFPEVEVIAGTATAGIPHGAIIADKMNLPFAYIRSKPKDH
                     GAGNQIEGRVAQGQKMVVVEDLISTGGSVLEAVAAAKREGADVLGVVAIFSYQLPKAD
                     KNFADAGVKLVTLSNYSELIHLAQEEGYITPEGLDLLKRFKEDQENWQEG"
     gene            14439..15203
                     /locus_tag="VXE25_000932"
     CDS             14439..15203
                     /locus_tag="VXE25_000932"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000394067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771414.1"
                     /translation="MEFFICNLVRVVQSPRFYMSLFLTLLCMSLGNFLAFNGIYKIEG
                     LSIFFAASSIRGFSPISLVAALICTLPYSSQIIEDAESHFLTAQLCRISKKRYLAIVG
                     STAIISSFLVFFLPYLLLLGINLLVTPYQEIYIGDYSGALKELFDSNQLLYSLVATLW
                     YGVWGAVFSIFGLASALLVKKKIGAIFIPVTYMMVGGIFWAILGLSYLEPVTTLALGY
                     QKDISLSLVSGHLAFILFVSCLVVYGTFFLHSEDYV"
     gene            15203..15955
                     /locus_tag="VXE25_000933"
     CDS             15203..15955
                     /locus_tag="VXE25_000933"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771415.1"
                     /translation="MKQFVQFYKKDFLAVLVYFILLLSCVLSSTVYLLRCRQYSIHPN
                     VLEWILVLLQDMTTGVYCFPFTYILFFFYLMNNYFNRLECRIRLKSIKHFTSFSFKLA
                     ALSTGIWTATLFLLIFLIAFSNGFSFSLEIKEVDFLGEFYGISIANNASFFIGFFFSY
                     IAYYFFLSLLTISSFSWFKKSNMSLVFLFTFLFVESLFWIYQLNNGIIGLLPIFQYMV
                     NSNPYALIYWLTLLSIIIPLTVFSVHRNWRRV"
     gene            15965..16663
                     /locus_tag="VXE25_000934"
     CDS             15965..16663
                     /locus_tag="VXE25_000934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000517353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771416.1"
                     /translation="MGKLSSHMWRLNQIIYTKYFWGYVLFWILICLGLWYWLEGNDRL
                     VIEILKGPNLSQNSFLVLSIWLLHWFIIHTFFLAVVYRRRASDFFMEVIRFSSIKLWI
                     RYQIWTCFLYGLILIMVKVLVIQFMLQLANWDIGVLFIVDSLNACVLSLLCFMLYALG
                     ANVQMNFACVSFFLLMIVFGGLFVGNRTNYLFYILNRGNGDIGRDLFLQLLFLVFLFK
                     SIFYFTRQKRRFIE"
     gene            16660..17307
                     /locus_tag="VXE25_000935"
     CDS             16660..17307
                     /locus_tag="VXE25_000935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001002414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0771417.1"
                     /translation="MNEIITLKNIELKLKKTCVFQNLNFSCKQGEIIGITGANGSGKS
                     VLFKLIAGLYSPSYGEVLINGENIVPERKIPANLGALIEEPGFINYYSGFKNLQYLAS
                     IRGVVGNQEINDTLKIVGLYEQKDQKVKTYSLGMRKKLGIAQAIMENPSILLLDEPMN
                     ALDKSSVENMRTLFRELSSEKGTTILIASHSEEDIRILCDKVYAIEDKVCTLCSD"
     gene            complement(17387..18252)
                     /locus_tag="VXE25_000936"
                     /pseudo
     CDS             complement(17387..18252)
                     /locus_tag="VXE25_000936"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000765255.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine ABC transporter substrate-binding
                     protein"
     gene            complement(18264..19021)
                     /locus_tag="VXE25_000937"
                     /pseudo
     CDS             complement(18264..19021)
                     /locus_tag="VXE25_000937"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000401.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
     gene            complement(19022..19309)
                     /locus_tag="VXE25_000938"
     CDS             complement(19022..19309)
                     /locus_tag="VXE25_000938"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEV0771418.1"
                     /translation="MTNVQLYYHIIIPQVLRRLLPQAINLVTRMIKTTSLVVLIGVVE
                     VTKVGQQIIDSNRLTIPTASFWIYGTILVLYFAVCYPISKLSTHLEKHWRN"
     gene            complement(19319..19699)
                     /locus_tag="VXE25_000939"
     CDS             complement(19319..19699)
                     /locus_tag="VXE25_000939"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001154138.1"
                     /note="The N-terminal region of this protein, as described
                     by TIGR01726, is a three transmembrane segment that
                     identifies a subfamily of ABC transporter permease
                     subunits, which specificities that include histidine,
                     arginine, glutamine, glutamate, L-cystine (sic), the
                     opines (in Agrobacterium) octopine and nopaline, etc;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit"
                     /protein_id="HEV0771419.1"
                     /translation="MQDSGIQVLFQGNNLLRILQGLGVTIGISILSVLLSMMFGTVMG
                     IIMTSHSRIIRFLTRLYLEFIRIMPQLVLLFIVYFGLARNFNINISGETSAIIIFTLW
                     GTAEMGDLVRGAITSLPKHQFESE"
     gene            complement(19659..20339)
                     /locus_tag="VXE25_000940"
     CDS             complement(19659..20339)
                     /locus_tag="VXE25_000940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000384089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEV0771420.1"
                     /translation="MDWSIVEQYLPLYQKAFFLTLHIAVWGILGSFLLGLIVSIIRHY
                     RIPVLAQVATAYIELSRNTPLLIQLFFLYFGLPRIGIVLSSEVCATLGLVFLGGSYMA
                     ESFRSGLEAISQTQQEIGLAIGLTPLQVFRYVVLPQATAVALPSFSANVIFLIKETSV
                     FSAVALADLMYVAKDLIGLYYETDIALAMLVVAYLIMLLPISLVFSWIERRTRHAGFG
                     NPSTLSRK"
     gene            20554..20700
                     /locus_tag="VXE25_000941"
     CDS             20554..20700
                     /locus_tag="VXE25_000941"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000120724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactate oxidase"
                     /protein_id="HEV0771421.1"
                     /translation="MSYKTSNAEGHVDFINTYDLEPMAQQVIPKAAFGYIASGAEDTF
                     TSFQ"
     gene            20828..22318
                     /gene="lysS"
                     /locus_tag="VXE25_000942"
     CDS             20828..22318
                     /gene="lysS"
                     /locus_tag="VXE25_000942"
                     /EC_number="6.1.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003055423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lysine--tRNA ligase"
                     /protein_id="HEV0771422.1"
                     /translation="MSTEHMEELNDQQIVRREKMAALREQGIDPFGKRFERTANSQEL
                     KDKYANLDKEQLHDKNETATIAGRLVTKRGKGKVGFAHLQDREGQIQIYVRKDAVGEE
                     NYEIFKKADLGDFLGVEGEVMRTDMGELSIKATHITHLSKALRPLPEKFHGLTDVETI
                     YRKRYLDLISNRESFERFVTRSKIISEIRRYLDQKGFLEVETPVLHNEAGGAAARPFI
                     THHNAQNIDMVLRIATELHLKRLIVGGMERVYEIGRIFRNEGMDATHNPEFTSIEVYQ
                     AYADFQDIMDLTEGIIQHAAKSVKGDGPVNYQSTEIKINEPFKRVHMVDAIREITGVD
                     FWQDMTLEEAKAIAAEKKVPVEKHYTEVGHIINAFFEEFVEETLIQPTFVYGHPVAVS
                     PLAKKNPEDQRFTDRFELFIMTKEYGNAFTELNDPIDQLSRFEAQAKAKELGDDEATG
                     IDYDYIEALEYGMPPTGGLGIGIDRLCMLLTDTTTIRDVLLFPTMK"
     gene            22943..24079
                     /gene="lctO"
                     /locus_tag="VXE25_000943"
     CDS             22943..24079
                     /gene="lctO"
                     /locus_tag="VXE25_000943"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000120720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-lactate oxidase"
                     /protein_id="HEV0771423.1"
                     /translation="MSYKTSNAEGHVDFINTYDLEPMAQQVIPKAAFGYIASGAEDTF
                     TLRENIRAFNHKLIVPHTLCNVENPNTEIEFAGEKLSSPIIMAPVAAHKLANEQGEVA
                     TARGVHEFGSLYTTSSYSTVDLPEISEALQGTPHWFQFYFSKDDGINRHIMDRVKAEG
                     YKAIVLTADATVGGNREVDKRNGFVFPVGMPIVEEYLPEGAGKSMDFVYKSAKQRLSP
                     RDVEFIAEYSGLPVYVKGPQCREDVERSLAAGASGIWVTNHGGRQIDGGPAAFDSLQE
                     VAEAVDRRVPIVFDSGVRRGQHVFKALASGADLVAIGRPVIYGLALGGSVGVRQVFEH
                     LNAELKTVMQLSGAQTIEDVKHFKLRHNPYNPTFPVDPRDLKLY"
     regulatory      24331..24419
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            24634..25302
                     /locus_tag="VXE25_000944"
     CDS             24634..25302
                     /locus_tag="VXE25_000944"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000449895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TenA family protein"
                     /protein_id="HEV0771424.1"
                     /translation="METQDYAFQPGLTVGELLKSSQKDWQAAINHRFVKELFAGTIEN
                     KVLKDYLIQDYHFFDAFLSMLGACVAHADKLESKLRFAKQLGFLEADEDGYFQKAFKE
                     LKVAENDYLEVTLHPVTKAFQDLMYSAVASSDYAHLLVMLVIAEGLYLDWGSKDLALP
                     EVYIHSEWINLHRGPFFAEWVQFLVDELNRVGKNREDLTELQQRWNQAVALELAFFDI
                     GYDV"
     gene            25545..26327
                     /gene="thiM"
                     /locus_tag="VXE25_000945"
     CDS             25545..26327
                     /gene="thiM"
                     /locus_tag="VXE25_000945"
                     /EC_number="2.7.1.50"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000202454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxyethylthiazole kinase"
                     /protein_id="HEV0771425.1"
                     /translation="MTSLKLLKEKAPLVICITNDVVKNFTANGLVALGASPAMSEFPA
                     DLEDLLKYAGGLLINIGTLTDENWKLYQAALKIAEKYNVPAVLDPVACGAGEYRKKVA
                     DDLINNYKLAAIRGNAGEIASLVGIDVASKGVDSAGVDNIDEIALAANEKFNIPIVVT
                     GEVDAIAVNGEVVTIHNGSAMMPKVIGTGCLLGAVIASFIGLEKGQELKSLETAMLVY
                     NIAGEMAEKRPNGHLPGTFKVEFINALYEITDEDVKEFKRVK"
     gene            26329..26958
                     /locus_tag="VXE25_000946"
     CDS             26329..26958
                     /locus_tag="VXE25_000946"
                     /EC_number="2.5.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000468574.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine phosphate synthase"
                     /protein_id="HEV0771426.1"
                     /translation="MFHKELLKLYFICGTTTCQGKNLYTVVKEALKGGITLFQFREKG
                     EGALEGLEKLELAIQIKELCKKYNVPFIVNDDIDLAMEIDADGVHVGQDDIGVDEIRK
                     LMPDKIIGLSIKNEEEFQQSKVEYVDYVGVGPVFDTQSKDDAGGAIGYEGLELMRKLL
                     PQMPLVAIGGIQTKHIKDIIKTNVDGVSIISAISYAKNIEKTVREMSEQ"
     regulatory      27167..27255
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            27516..28076
                     /locus_tag="VXE25_000947"
     CDS             27516..28076
                     /locus_tag="VXE25_000947"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000915269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HEV0771427.1"
                     /translation="MLKKWQLKDVILLAFLSIFFGGVFVGSGYVYNILSLLLTPLGLQ
                     AFANEILFGLWCMAAPIAAIFVPRVGSATIGEVLAALAEVLYGSQFGLGALLSGLVQG
                     LGSEFGFIVTKNRYESWLSLTANSIGITLVSFVYEYIKLGYYAFSLPFVLSLLVVRFI
                     SVYFFCTILVRAIVKLYHQFATGGKA"
     gene            28077..29462
                     /locus_tag="VXE25_000948"
     CDS             28077..29462
                     /locus_tag="VXE25_000948"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000522086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0771428.1"
                     /translation="MGLELRAIQSPIFSEPFDFTFHAQAFTLLVGSSGSGKSSLFQVI
                     AQVSSLPYSGQVLIDGSEVSQLSIIARVQKVGILFQNPNHQFTMESLFEELIFTLENI
                     GYHLQEIDSKIAEVVQQCRCEAILHRPIHHLSGGEKQKAALAVLFAMNPRVYLLDEPF
                     ASIDRKSRIEILEILKELALDGKTVILCDHDLSDYKAYIDHMVELRDGKLREINQIPS
                     YEMTQVASKEVASSPELFHMNRVTGELGNRPLFSIADFTFYQGISCILGDNGVGKSTL
                     FRSILQFQKYKGRIAWKGTVLKKKKSLYRDLTGVVQEAEKQFIRVSLREELQLDGPDS
                     ERNQRIFQALRYFDLEQAVDKSPYQLSGGQQKILQLLTILTSKASVILLDEPFAGLDD
                     RACHYFCKWIVEERNQGRSFLLISHRLDPLISVVDYWIEMTSQGLRHVKEVTITKPLT
                     SQSSNTQGEVR"
     gene            29464..30114
                     /locus_tag="VXE25_000949"
     CDS             29464..30114
                     /locus_tag="VXE25_000949"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000241367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt ABC transporter permease"
                     /protein_id="HEV0771429.1"
                     /translation="MVKVATQTPIISLFLLILSLETSFIPSIALNLSVVAFCILFMLY
                     YRRFKMLAWMIILAILPSFANYWAVQLHGDASQAVMLGTRAFVTVCIGLVFVSSISLK
                     ELLLYLAQKGLSRSWSYALIVVFNSFPLIQQEIKSLKEACLLRGQELHFWSPLIYSKV
                     LMTVFRWRHLYLRALSAHGYDEHAQLKNSYRTFYIPKKTKLIYLLFFLLLQTSLFL"
     gene            30125..30817
                     /gene="tenA"
                     /locus_tag="VXE25_000950"
     CDS             30125..30817
                     /gene="tenA"
                     /locus_tag="VXE25_000950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864194.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiaminase II"
                     /protein_id="HEV0771430.1"
                     /translation="MEFTDIAMELSKKAWQASFHHPFILQLQEGNLEPAIFRYYLIQD
                     AYYLKAFSEIYHLLADKTSNQEMKRLLKQNAQGLVEGELFIRQQFFKELEINDQEMEQ
                     HPIAPTCYHYISHIYRQFAEPNLAIAFASLLPCPWLYHDIGKSLNLKPSPNPLYQQWI
                     ETYITDELEQQIREEGALVNQLYRESDETDKQKMLDAFHISVHMEAKFWEMAYQHQTW
                     KSDLQSLEKGEE"
     gene            30822..31346
                     /gene="thiW"
                     /locus_tag="VXE25_000951"
     CDS             30822..31346
                     /gene="thiW"
                     /locus_tag="VXE25_000951"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001225563.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy coupling factor transporter S component
                     ThiW"
                     /protein_id="HEV0771431.1"
                     /translation="MRKHQLQVHKLTILSMMIALDVVLTPIFRIEGMAPMSSVVNILA
                     GIMMGPVYALAMATVTAFIRMTTQGIPPLALTGATFGALLAGLFYKYGRKFYFSALGE
                     IVGTGIIGSIVSYPVMVLFTGSAAKLSWFIYTPRFFGATLIGTAISFIAFRFLIKQEF
                     FKKVQGYFFSERID"
     gene            31346..32149
                     /locus_tag="VXE25_000952"
     CDS             31346..32149
                     /locus_tag="VXE25_000952"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001155192.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxyethylthiazole kinase"
                     /protein_id="HEV0771432.1"
                     /translation="MQEFTNPFPIGSSSLIHCMTNEISCEMLANGILALGCKPVMADD
                     PREVLDFTKQSQALFINLGHLSAEKEKAIRMAASYANQSSLPMVVDAVGVTTSSIRKS
                     LVKDLLDYRPTVLKGNMSEIRSLVGLKHHGVGVDASAKDQETEDLLQVLKDWCQTYPG
                     MSFLVTGPKDLIVSENQVAVLENGCTELDWITGTGDLVGALTAVFLSQGKTGFEASCL
                     AVSYLNIAAEKIVVQGMGLEEFRYQVLNQLSLLRRDENWLDTIKGEVYE"
     gene            32142..32774
                     /locus_tag="VXE25_000953"
     CDS             32142..32774
                     /locus_tag="VXE25_000953"
                     /EC_number="2.5.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001078228.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine phosphate synthase"
                     /protein_id="HEV0771433.1"
                     /translation="MNREALRLYLVTNRYQDSVESFLAKVETACRSGVTIVQLREKNL
                     TTNQYYQLAKQVKEITDAYQVPLIIDDRLDVCLAVDAAGLHIGDDELPVSVARQVLGP
                     EKILGVTAKTVKRALEAEKSGADYLGTGAIFPTTTKENAPITLISTLKTICQTVAIPI
                     VAIGGLTSENIDQLMGTGIAGVAVVRDLMQAEDIEAKTQAFLTKLHDILS"
     gene            complement(32983..33774)
                     /gene="thiD"
                     /locus_tag="VXE25_000954"
     CDS             complement(32983..33774)
                     /gene="thiD"
                     /locus_tag="VXE25_000954"
                     /EC_number="2.7.1.49"
                     /EC_number="2.7.4.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000221716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional hydroxymethylpyrimidine
                     kinase/phosphomethylpyrimidine kinase"
                     /protein_id="HEV0771434.1"
                     /translation="MTYLPVALTIAGTDPSGGAGIMADLKSFQARDVYGMAVVTSLVA
                     QNTRGVQLIEHVSPQMLKAQLESVFSDIPPQAVKTGMLATTEIMEIIQPYLKKLDCPY
                     VLDPVMVATSGDALIDSSARDYLKTNLLPLATIITPNLPEAEEIVGFSIHDPEDMQRA
                     GRLILKEFGPQSVVIKGGHLKGGAKDFLFTKNEQFVWESPRIQTCHTHGTGCTFAAVI
                     TAELAKGKSLYQAVDKAKAFITKAIQDAPQLGHGSGPVNHTTFKD"
     regulatory      complement(33858..33956)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            34140..34535
                     /locus_tag="VXE25_000955"
     CDS             34140..34535
                     /locus_tag="VXE25_000955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256226.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CopY/TcrY family copper transport repressor"
                     /protein_id="HEV0771435.1"
                     /translation="MQISDAEWQVMKIIWMQGEQTSTDLIRVLAERFDWSKSTVQTLL
                     ARLVEKECLTRKKEGKSFVYSALLTLDQSRDLLVQDIKDKVCSRRIRNLLADLIVECE
                     FTQTDLEDLEAVISEKKSSAVTEVRCNCM"
     gene            34546..34917
                     /locus_tag="VXE25_000956"
     CDS             34546..34917
                     /locus_tag="VXE25_000956"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000932058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupredoxin domain-containing protein"
                     /protein_id="HEV0771436.1"
                     /translation="MLNSIVTIICIALIAFILFWFFKKPEKSGQKAQQKNGYQEIRVE
                     VMGGYTPELIVLKKSVPARIVFDRKDPSPCLDQIVFPDFGVHTNLPMGEEYVVEITPE
                     QAGEFGFACGMNMMHGKMIVE"
     gene            34927..37170
                     /locus_tag="VXE25_000957"
     CDS             34927..37170
                     /locus_tag="VXE25_000957"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136280.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heavy metal translocating P-type ATPase"
                     /protein_id="HEV0771437.1"
                     /translation="MTEIVKASLENGIQKIRIRAEKGYHPAHIQLQKGIPAEITFHRA
                     TPSNCYKEILFEEEGILEPIGVDEEKVIRFTPQELGRHEFSCGMKMQKGSYIVVEKTR
                     KSLSLLQRFWITSIFTVPLVILMIGMLAGSISHQVMHWGTFLATTPIMLVAGKPYIQS
                     AWASFKKHNANMDTLVALGTLVAYFYSLVALFAGLPVYFESAGFILFFVLLGAVFEEK
                     MRKNTSQAVEKLLDLQAKTAEVLSDDSYVQVPLEQVKVGDLIRVRPGEKIAVDGVVVE
                     GVSSIDESMVTGESLPVDKTVGDTVIGSTINHSGTLVFRAEKVGSETVLAQIVDFVKK
                     AQTSRAPIQDLTDKISGIFVPVVVILGIMTFWVWFVLLRDSVVVLGASFVSSLLYGVA
                     VLIIACPCALGLATPTALMVGTGRSAKMGVLLKNGTVLQEIQKVQTLVFDKTGTLTEG
                     KPVVTDIIGDEVEVFGLAASLEDASQHPLAEAIVKRASEAGLEFQTVENFQALHGKGV
                     SGRVNGKQVLLGNAKMLDGMDISNTYQDKLEELEKEAKTVVFLAVDNEIKGLLALQDI
                     PKENAKLAISQLKKRGLRTVMLTGDNAGVARAIADQIGIEEVIAGVLPEEKAHEIHKL
                     QAAGKVAFVGDGINDAPALSVADVGIAMGAGTDIAIESADLVLTTNNLLGVVRAFDMS
                     KKTFHRILLNLFWAFIYNVVGIPIAAGVFSGVGLALNPELAGLAMAFSSVSVLTSSLL
                     LNFSKID"
     gene            37377..39152
                     /gene="spxB"
                     /locus_tag="VXE25_000958"
     CDS             37377..39152
                     /gene="spxB"
                     /locus_tag="VXE25_000958"
                     /EC_number="1.2.3.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000191798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate oxidase"
                     /protein_id="HEV0771438.1"
                     /translation="MTQGKITASAAMLNVLKTWGVDTIYGIPSGTLSSLMDALAEDKD
                     IRFLQVRHEETGALAAVMQAKFGGSIGVAVGSGGPGATHLINGVYDAAMDNTPFLAIL
                     GSRPVNELNMDAFQELNQNPMYNGIAVYNKRVAYAEQLPKVIDEACRAAVSKKGPAVV
                     EIPVNFGFQEIDENSYYGSGSYERSFIAPALNEVEIDKAVEILNNAERPVIYAGFGGV
                     KAGEVITELSRKIKAPIITTGKNFEAFEWNYEGLTGSAYRVGWKPANEVVFEADTVLF
                     LGSNFPFAEVYEAFKNTEKFIQVDIDPYKLGKRHALDASILGDAGQAAKAILDKVNPV
                     ESTPWWRANVKNNQNWRDYMNKLEGKTEGELQLYQVYNAINKHADQDAIYSIDVGNTT
                     QTSTRHLHMTPKNMWRTSPLFATMGIALPGGIAAKKDNPDRQVWNIMGDGAFNMCYPD
                     VITNVQYDLPVINLVFSNAEYGFIKNKYEDTNKHLFGVDFTNADYAKIAEAQGAVGFT
                     VDRIEDIDAVVAEAVKLNKEGKTVVIDARITQHRPLPVEVLELDPKLHSEEAIKAFKE
                     KYEAEELVPFRLFLEEEGLQSRAIK"
     gene            39263..39610
                     /locus_tag="VXE25_000959"
     CDS             39263..39610
                     /locus_tag="VXE25_000959"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003017645.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HEV0771439.1"
                     /translation="MNLNQLDIIVSNVPQVCADLEHILDKKADYADDGFAQFTIGSHC
                     LMLSQNHLVPLENFQSGIIIHIEVEDVDQNYKRLNELGIKVLHGPTVTDWGTESLLVQ
                     GPAGLVLDFYRMK"
BASE COUNT        11871 a         7179 c         8691 g        12081 t
ORIGIN      
        1 aaaaagaacc aatgtgcagg ttgttgctag cctacatatt ggttcttatc atttctcaac
       61 tatcaaactg aacttcttct agtagatagt caataaagcg ttcgcccatc ttagataggc
      121 tggttttctc atgctggata tagaccagct caatcgggtc atcaatatcc agtgggatag
      181 aaacgatatt gtctccgttt aggttgctgt tcaaaatccc tgtcgcaatg gtataaccat
      241 ccaaaccaat caagagatta aagagggtgg cacggtcact gaccacaatg gatttcttgt
      301 ggtgttcttg agaaagaatc tcttctgaaa agtagaagga gttgtgcgtc ccttggtcat
      361 agctgaggta agggaaattc tccaaatcag acagtttcac cttgtctttc tttgccagag
      421 ggttggtctt gctgacaaag atatgcggtt gcgctgtgaa gagatggtgg gctagcaggt
      481 gattgtcatc cagcatcttg gttaaaacat cacggttgta actgtttaag aagaggaccc
      541 cgacctcact gcggaagttc ttgacgtcgt cgataatctc ccaagtccga gtttcacgaa
      601 ggaagagttc gtatttctcc atatcgcttt tcttgagcaa agagacaaag gcattgacca
      661 caaaggcata gtgttgagac gaaacgctaa agagttcgcg gtgggcaaca ggatttttat
      721 agcgttcctc cagaagctgg gtctgctcga caacctgacg ggcataagag agaaactcca
      781 tcccatcacg ggtcaaggta atacccttgg gattgcggat aaagatttca atgcccattt
      841 cattttccaa atctcgcact gcattggaga gactgggctg agtgataaag agttgcttgg
      901 ctgcctcatt catagagcca gtttcgacga ttttgataat ataatgtaat tgttgaattc
      961 tcatgttttt attgtaccac acttgcctta gaatcgccaa agaagatagg aaaataagga
     1021 gcattgtgtg agtctcttct tgaaaaaaac acaaaatttt gctagaatga gtcttatgaa
     1081 aacattctat gatgtgcagc aattcctcaa acgatttggt attattgttt acatgggaaa
     1141 acgcttatat gatattgaac tgatgaagtt ggaactatct cggatttacg atgcagggtt
     1201 gatggataaa ttagactatc tagaggcaga agcagttctt cgcagagagc acaaggtaga
     1261 attggattat attgagaaaa atggagaaaa gaactaatgg ttacttggat tttgtgggca
     1321 cttatactag caatgttggc gtggatgggc tttaactatc ttcgtattcg tcgtgcggct
     1381 aaaattgtgg acaatgagga gtttgaagcc ttgattcgta cgggtcaatt gattgatttg
     1441 cgcgacccag cagaattcca cagaaaacat atccttggtg cacgcaatat tccttcaagt
     1501 cagttgaaaa ctagtcttgc agcccttcgt aaagataaac ctgtccttct ctacgagaac
     1561 caacgtgcgc aacgagttac aaatgcagct ctttacttga aaaaacaagg tttttctgag
     1621 atttatatcc tttcttatgg cttggattct tggaaaggga aagtgaagac tagctaacct
     1681 tatttccaaa ttagtcgaat gataggatga agctattgtt ttatagtata attaatttgt
     1741 ataaaattta aggagttctt agaacataaa agaaaagaag aaaaatccac tttttgtggg
     1801 tatcttgtcg attattcttg gtttgttatt tccaattgta ggcctgattt tgggtatcat
     1861 aggattggtc ttggctattt cataccaaaa agagtcacaa ttagactata aaatagaaaa
     1921 gattcttaat atcttaggaa ttgtgatttc tgtagttaac tggattgtag caatcgcctt
     1981 aatttttcgg taaataaaag aaaaaagctt tagttttaaa gcttttttta ttttatcgac
     2041 tcatctctaa atagttttta atgatttgta actctttttg gttcaaaggg cggtagttac
     2101 cttctgctaa atctgggttc aatgtgaagt ccccaaattg gattctcttg aggctagtta
     2161 ccttaacacc aaccgagagg aacattttct tgatttgatg aaattttcct tctgaaatgg
     2221 tgatagaggc ttgactgagg gaaggacttg cagatagaat ctctagtttt gcgggtttac
     2281 agacagtacc atctaaaaag acaattccct tttgaaaggc ttggatatgg tcaggtgtta
     2341 gaagtccatt aacctcaact tgataagtct tatcgacatg atattgggga tggaggagtt
     2401 ggaagcccaa gggaccgtta tcggtcaaga gaaggagtcc tgttgtatct cggtccagtc
     2461 ggccgacggc atagagcttg tcagactgga tgtcagatgg aagcaggtcc atgacggtcg
     2521 gaagttcctt gtctttgttg gctgtaacga caccagcagg tttatgaagc ataagatagg
     2581 tgtgttcata gccttgaatg attcgatcct gaaaaaggag ttcttgtagt cctgtatcga
     2641 tattttgagc tagggagcgg gctgggcaac catcgactag aatttcccct ctgaggagtg
     2701 cttgcttcat ggcctttcgg ctaacttttt cttgggctaa taaattatct aaacgcatac
     2761 tgtgcctatc ttatcataag tcgcttgctt tgaaaaggct tgacgtgaaa agaaaagcgg
     2821 agtgaaaaca tttacacttg cttgagttat gttatttatt tgaaattatg gtataatcgt
     2881 tcagttagaa aataaatttt gaatattata gaggaaatca tgacaaaatt aagagaagat
     2941 atccgtaaca ttgcgattat cgcccacgtt gaccacggta aaacaaccct ggttgacgaa
     3001 ttattgaaac aatcagaaac gcttgatgca cgtactgaat tggcagagcg tgctatggac
     3061 tcaaacgata tcgaaaaaga gcgtgggatt accatccttg ctaaaaatac tgccgttgct
     3121 tacaacggaa ctcgtatcaa cattatggac acaccaggac acgcggactt cggtggagaa
     3181 gttgagcgta tcatgaaaat ggttgacggt gttgtcttgg tcgtagatgc ctatgaagga
     3241 accatgccac aaactcgttt cgtattgaaa aaagccttgg aacaagacct tgtcccaatc
     3301 gtggttgtta acaaaatcga taagccatca gctcgtccag cagaagtagt ggatgaagtc
     3361 ttggaacttt tcatcgagct tggtgcagat gacgaccagc ttgatttccc agtggtttat
     3421 gcttcagcga tcaacggaac ttcttcattg tcagatgatc cagctgacca agaagcgact
     3481 atggcaccaa tctttgacac gattatcgac catatcccag ctccagtaga taactcagat
     3541 gagcctttgc agttccaagt gtcacttttg gactacaatg actttgttgg acgtatcggt
     3601 atcggtcgtg tcttccgtgg tacagttaag gttggggacc aggttaccct ttctaaactt
     3661 gacggtacaa ctaaaaactt ccgtgttaca aaactcttcg gtttctttgg tttggaacgt
     3721 cgtgaaatcc aagaagccaa agcgggtgac ttgattgccg tttcaggtat ggaagacatc
     3781 tttgtcggtg aaaccatcac tccgacagat gcagtagaag ctcttccaat cctacacatc
     3841 gatgagccaa ctcttcaaat gactttcttg gtcaacaact caccatttgc tggtaaagaa
     3901 ggtaaatggg taacttctcg taaggtggaa gaacgcttgc aggcagaatt gcaaacagac
     3961 gtttcccttc gtgttgaccc aactgattca ccagataaat ggactgtttc aggacgtgga
     4021 gaattgcact tgtcaatcct tatcgaaaca atgcgtcgtg agggctatga acttcaagta
     4081 tctcgtccag aagttatcgt aaaagaaatc gacggtgtta aatgtgaacc atttgaacgt
     4141 gtacaaatcg acactccaga agaataccaa gggtctgtta tccaaagcct ttctgaacgt
     4201 aaaggtgaaa tgttggatat gatttcaact ggtaatggtc aaactcgttt ggtcttcctt
     4261 gttccagcgc gtggtttgat tggatactca actgagttct tgtcaatgac tcgtggttac
     4321 ggtatcatga accatacctt cgaccaatac ttgccattga ttccagggga aattggtgga
     4381 cgtcaccgtg gtgcccttgt ttctatcgat gctggtaagg ctacaactta ctcaatcatg
     4441 tctatcgaag aacgtggtac gatctttgtc aacccaggta ctgaggttta tgaaggaatg
     4501 atcatcggtg aaaactctcg tgaaaatgac ttgacagtta acatcacgaa ggcaaaacaa
     4561 atgaccaacg ttcgttcagc tactaaggac caaacagctg ttatcaagac gcctcgtatc
     4621 ttgacacttg aagagtctct tgagttcttg aacgacgatg agtacatgga agtaacgcct
     4681 gagtctatcc gtttgcgtaa acaaatcctt aacaaagcag agcgtgagaa agctaacaag
     4741 aagaaaaaat cagctgaata agagctagaa agagagaaag atggtctatt tagtcctagg
     4801 aattttactg ctcctactct atgtatttgc gacaccagaa agcattaaag ggactgtcaa
     4861 tatcgtcgct atggtatgta ttttagtggc actcttgatt ttattggttc tatcttttct
     4921 gaaaattttt caattaccaa cagaaatatt cctagcaata gccatgttga tcctagctta
     4981 ctttagtgtt agagacatca cactcatgcc agtcaaaaaa agtaaaagaa gataaaaaga
     5041 gagttttggc tctctttttt gctaggaatt ttacaagatt gcaatttatt tttgagttat
     5101 caccatctct tttgtttgga taatatgaat gggaaaaact tgaataaaat tctttaatgg
     5161 catctatttt atatttggtt agtactggtt gcatattatt ttgaaataaa actactatat
     5221 aatattattc atagaggcaa tgtagtaaaa tatctaaaaa attcgatttt ttccttgaca
     5281 acaaataata aaaatgatat ttttatcaca taagaaagcg gtttcaacaa aagagagagg
     5341 agggtttatt ttgttgcatt gttgctcaag gtgtgctttt tttgaaagaa aaaataaaat
     5401 gaaaacgaaa aaacatagat tacttgctct agctcttatt tcaagtttta cattattggg
     5461 agctgcatca gctgctgtac aatatccaga tggaggagta tggacgtatg gagaaggttc
     5521 aggaggtggt tgggcttttt caaattacta tcatggtaaa aaatatcatt attcttctct
     5581 tgtaagtaga tggaatagtc attcagataa aggagaagct tctgctggaa aaacctccta
     5641 tgcatggatt tggactaaat ggggagaaca agtagcattt tactgtgatt atgactaatc
     5701 gttcattgat ttaaatcgtt ccccttgtaa gaaattacag ggggaatttt gtttacaagg
     5761 agtctactat gaagaaacta ttcatattat tatcaacttt ttttctcagc ttcttccttg
     5821 cttggattat tgtcttacgt gcgccacaat atttatatgc aagctatgat tccgtttctt
     5881 tacttcgtgt caaaaaagat actcaggaac cgacgcgtga ggtatttgaa caggaattgg
     5941 agaattttgc aaactcagaa cagagtttaa tagctagaag aattgtagag ccgagtaagg
     6001 atgggacgac tcactttact tatgcaactt atggtcaggg aactttacca aaagaattcc
     6061 aagaagctag ccaagaaagt cgtgaacgta gtgatccgct aaatagttat ctccttttgt
     6121 caggctcctt gacgaaagaa aagcttgccg ataaattagg agatttgggt tataaagcaa
     6181 gtgctgaccg aaagataccg ccctattttc ttgcttttcg aatattacta aatcccctta
     6241 ttttaattag tttagcaata tttggcttat ctttctttgc tttagtgatt atcactcgga
     6301 ttaaggaaat gagagcagca ggtataaaac tcttttctgg tcagactctc ttatccatca
     6361 tggggcattc tttatctact gatatcaaat ggctccttct atcagccctc ctttccttcc
     6421 taggtggggg agtcgttctt tttagtcaag gtttgtttta tcctatcttg ttagcaacct
     6481 atggttttgg gattagtttc tatctgttgt ttttattggc gatttcaatt ttactaatgc
     6541 ttctttatct aatgagtttg agttacaaag cattagttcc cgttattaag gggagattac
     6601 cccttaaacg cctgatgatt ttaaccctat tgtgtcagtt ggttgctgtc tttacagtag
     6661 gctacgctgt taagacaggt ttgatgtctt accaacgatt gaaagaactt gaaatttcaa
     6721 aacaagcatg gcaggataga gcagactatt atcaaatttc ttttggctta ggtgatagag
     6781 gaaaagatac agaaaatcag agcaagtggt atgcctttgc caaggaagca atcgaagaag
     6841 aacaagctct ttatgtaaag gataatctgc tccattttgc caatccacaa ggaaaaaatg
     6901 aacagggaga gacactggat acctatagtc cagatgctaa tacgctctat gttagtccca
     6961 gttatttgga caaggaaaag gtcgtggtag atgctgagac caaacagaag ttagcccatc
     7021 tccaaaaagg tgagtttatc ctcttgctcc cagaacattt gcgctctcga gaagcagaac
     7081 ttaagaaagt ttttgaagaa agattgagtt attatggaaa atctggtgag gaggcaagtg
     7141 ctcctttgga ttatgagatg aaagcgcacg ttagttatct ttcaatggga gaaaagcggt
     7201 ttgtttataa taacggtgag aatcccgtat ccactcagta tttgactgat ccgattttag
     7261 tggtattcac gccgacttct acaggtgata gttttatatc cttatctagt tggtctatca
     7321 atgctggaaa acaactcttt atcaaaggat atgagagtgg gctagaactc ttgaagaaag
     7381 ctggaattta tgagcaagta tcctatctta aagaaggaag aagtgtttat ctaactcgtt
     7441 ataatgaagt tcaaactgaa acagcaactt taatcttagg agctattgtg gggatagcta
     7501 gttccttgtt actattttat tctgtcaatc ttctatattt cgagcaattc cgccgagata
     7561 tcttgattaa acgaatttca ggtttacgat tttttgaaac acatgctcag tatatggtta
     7621 gccaatttgc cagttttgta tttggtgcta gtctctttat tttaagcagt cgagacttgg
     7681 tgattggctt gctcacttta ttggtctttc tagctagtgc agttttgacg ctttaccgtc
     7741 aagcgcagaa agaatctcgt gtttctatga caattatgaa aggaaaatag gatgattgaa
     7801 ctaaagaata tatctaaaaa atttggaagc cgtcagctat tttcagatac gaatcttcat
     7861 tttgaaggtg ggaaaattta tgccttaatc ggtacaagtg gctgtggtaa gacaacactc
     7921 ttgaatatga ttggacgatt ggagccatat gacaaagggc aaatcatcta tgatggcact
     7981 tctcttaagg acatcaagcc ttctgttttc tttagagatt acttaggata cttatttcaa
     8041 gattttggct taattgaaag ccaaaccgtc aaagagaatc tcaatctgag tttagttggt
     8101 aaaaagttga aggaaaaaga gaaaatctct ttgatgaaac aagctctaaa ctgtgtaaac
     8161 ctctcttatt tggatttgaa gcaacctata tttgagttat caggaggaga agcacaacgt
     8221 gttgcactag cgaagataat tttaaaggat ccgcctttga ttcttgcaga tgaaccaacc
     8281 gcttccttag accccaaaaa ttctgaggaa ttactttcca tcctagaatc tttaaaaaat
     8341 ccgaatcgga ccattattat tgcgacccac aatcctctga tttgggagca agtggatcag
     8401 gtcattcgag ttaccgattt atcacataga tgatatggta agattcagtt agaagaaaga
     8461 gtcacaaaca cactttgtgg cttttttatt tccataaaaa tggtaaaata gtaggagtag
     8521 aaatggagtt cgagacatga aagtaataga tcaatttaaa aataagaaag ttcttgtttt
     8581 aggtttggcc aagtctggtg aatctgcggc tcgtttgttg gacaagttag gtgccattgt
     8641 gacagtaaat gatgggaaac cattcgagga caatccagct gcccaatgtt tgctggaaga
     8701 agggatcaag gtcattacag gtggccatcc tttggaactc ttggatgaag agtttgccct
     8761 tatggtgaaa aatccaggta tcccctacaa caatcccatg attgaaaagg ctttggccaa
     8821 gggaattcca gtcttgactg aggtggaatt ggcttatttg atttcagaag caccgattat
     8881 tggtatcaca ggatcgaacg gtaagacaac cacaacgact atgattgggg aagttttgac
     8941 tgctgccggg caacatggtc ttttatcagg gaatatcggc tatccagcta gtcaagtggc
     9001 ccaaactgcg tcggacaagg acacgcttgt tatggaactt tcttctttcc aactcatggg
     9061 tgttcaagaa tttcatccag agattgcggt tattaccaac ctcatgccaa ctcatatcga
     9121 ctaccatggg tcattttcgg aatatgtagc agccaagtgg aatatccaga acaagatgac
     9181 agcagctgat ttccttgtct tgaactttaa tcaagacttg gcaaaagact tgacttccaa
     9241 gacagaagcc actgttgtag cattttcaac acttgaaaag gttgatggag cttatctgga
     9301 agatggtcaa ctctacttcc gtggtgaagt agtcatggca gcgaatgaaa tcggtgttcc
     9361 aggtagccac aatgtggaaa atgcccttgc gactattgct gtagccaagc ttcgtgatgt
     9421 ggacaatcaa accatcaagg aaactctttc agccttcggt ggtgtcaaac accgtctcca
     9481 gtttgtggat gacatcaagg gtgttaaatt ctataacgac agtaaatcaa ctaatatctt
     9541 ggctactcaa aaagccttgt caggatttga caacagcaag gtcgtcttga ttgcaggtgg
     9601 tttggaccgt ggcaatgagt ttgacgaatt ggtgccagac attactggac tcaagaagat
     9661 ggtcatcctg ggtcaatctg cagaacgtgt caaacgggca gcagacaagg ctggtgtcgc
     9721 ttatgtggag gcgacagata ttgcagatgc gacccgcaag gcctatgagc ttgcgactca
     9781 aggagatgtg gttcttctta gtcctgccaa tgccagctgg gatatgtatg ctaactttga
     9841 agtacgtggc gacctcttta tcgacacagt agcggagtta aaagaataaa atatgaaaaa
     9901 aattgtcttt acaggtgggg ggacggttgg acacgttacc ctcaatcttt tgttaatgcc
     9961 caagttcatc gaagatggtt gggaagtcca ctatatcggg aacaagcgtg gtatcgaaca
    10021 ccaagaaatc cttaagtcag gtttggatgt cactttccac tccattgcga ctgggaaatt
    10081 gcgtcgctat ttctcttggc aaaatatgct ggacgtcttc aaagttggct ggggaatcgt
    10141 ccaatcgctc tttatcatgt tgcgacttcg tccacagacc cttttttcaa agggaggctt
    10201 tgtctcagta ccgcctgtta tcgctgcgcg tgtgtcagga gtgcctgtct ttattcacga
    10261 atctgacctg tctatgggct tggccaataa aatcgcctat aaatttgcga ctaagatgta
    10321 ttcaaccttt gaacaagctt cgagtttggc taaggtcgag catgtgggag cggtgaccaa
    10381 ggtttcggac aaaaacactc cagaaccaga tgaattggtg gatattcaaa cccactttaa
    10441 tcccaaattg ccaactgtat tgtttgtcgg cggttctgca ggcgctcgtg tctttaacca
    10501 attggtgaca gaccataaga aagaactaac agagcgctac aatattatca atctaactgg
    10561 agattctagt ctgaatgagt tgaggcaaaa tctttttcgt gttgactatg tgaccgatct
    10621 ctatcaaccc ttgatggaat tggctgatat tgttgtgaca cgaggtggtg ccaatacgat
    10681 ttttgagctc ttggcgatag caaaattgca tgtcattgtt ccgcttggtc gtgaagctag
    10741 tcgtggtgac cagattgaaa atgcagctta ctttgtaaaa aaaggctatg cagaagacct
    10801 tcaagaaagc gatttgacct tggatagttt ggaagagaag ctttctcact tactaagtca
    10861 caaggaagat taccaagcta agatgaaagc ttctaaggaa ttgaaatctc tagcagattt
    10921 ttatcaattg ttgaaaaaag atttatcata aggaaagtaa atgtcaaaag ataagaaaaa
    10981 tgaggacaaa gaaaccctcg aagaattgaa agagttatca gaatggcaga aacgaaacca
    11041 agaatatcta aaaaagaagg ctgaagaaga ggcggctcta gctgaggaga aggaaaagga
    11101 aagacaagct cgaatgggag aagaatctga gaagtcagag gataaacagg accaggagag
    11161 tgaaacagac caggaagatt cagaatcagc taaggaagag tctgaagaaa aagtagcatc
    11221 ctcagaggct gacaaagaga aagaagagaa agaagaacca gagtctaaag agaaggagga
    11281 acaggataaa aagctttcta aaaaggctac aaaggaaaaa ccagccaaag caaagattcc
    11341 tggtatccat atcttgcgag ccttcacgat tttatttcca agtctgcttt tattgattgt
    11401 ctctgcctac ttgctcagtc cttatgcgac catgaaagat attcgtgttg agggaacagt
    11461 gcaaactaca gctgatgata ttcgacaggc ttcaggcatt caggattcgg attatacgat
    11521 taatcttctg ctagacaagg caaaatatga aaagcagatt aagtctaact attgggttga
    11581 atcagctcaa cttgtctatc aatttccaac taagttcact attaaggtca aggaatatga
    11641 tattgtggcc tactatattt ctggtgaaaa tcattatcct attctttcca gtggtcagct
    11701 tgagactagt tctgtgagtc tgaacagttt accagaaact tatttatcag ttctctttaa
    11761 tgatagtgaa caaatcaagg tttttgtctc agaacttgct caaattagcc cagaactcaa
    11821 ggcggctatc caaaaggtgg aattagcccc aagcaaggtg acatccgatt taattcgatt
    11881 gaccatgaat gattcggacg aagtcttggt tcctctatct gaaatgagta agaaactgcc
    11941 atattacagt aagattaagc cacaattgtc agaaccgagt gtggtcgaca tggaagctgg
    12001 aatttacagt tacactgtgg cggataaatt aattatggag gctgaggaaa aagccaaaca
    12061 agaggccaag gaagccgaga aaaaacagga agaagaacag aaaaaacaag aggaagagag
    12121 caattgaaat caaacgaccc agcgctcatc gcgtcgctag gtttaccttt tctcttatag
    12181 ttctttagtg accatgtttt tacttgacaa gtgctagtag aaataataga ataatagaaa
    12241 acctttaaag cagtccagag aggcagctaa ggttagacgg tgaaagggtg gagactaccc
    12301 atttttcgtg gaaccttgct gttggcaggt tccttttttc gtggcttctg ttggccagac
    12361 tctctcacta gtaaaggtaa aaggagaaac ctatgcgaga acatcgtcca atcattgctc
    12421 ttgattttcc tagttttgag gcggtcaagg aatttttagc tcttttccca gcagaagaaa
    12481 gcctttatct caaggtaggg atggagcttt attacgcagc ggggcctgag attgtgtcct
    12541 acttaaaagg tttgggtcat agtgtctttt tggatctcaa acttcatgac attcctaata
    12601 cagtcaagtc agcaatgaag atcctatctc agcttggtgt cgatatgacc aatgttcatg
    12661 cggctggtgg tgtagagatg atgaaggctg cgcgtgaagg tcttggaagt caagctaaat
    12721 tgatcgctgt aactcagctc acatcaacgt cagaagctca gatgcaggag tttcaaaata
    12781 tccaaaccag tctgcaagag tctgtgattc actatgccaa gaagacagct gaagctggct
    12841 tggatggtgt tgtttgctcg gctcaggaag tacaagtcat caagcaggct accaatccag
    12901 attttatctg tctgacacca gggattcgtc cagctggtgt tgcagttgga gatcaaaaac
    12961 gagtcatgac acctgctgat gcctatcaaa tcggcagtga ctatatcgta gtgggacgtc
    13021 ccattatcca agctgaggat cctgttgcag cttatcatac catcaaggat gaatggacac
    13081 aggactggaa ttaaagaact agattagaaa aataaaagga gaataccatg acacttgcta
    13141 aagatatcgc tagccacctc ttgaaaatcc aagccgttta cctcaaacca gaggaaccct
    13201 tcacttgggc atctggtatc aagtcaccga tttacactga taatcgtgtg acactagcct
    13261 atccagaaac tcgtacccta attgaaaatg gttttgtgga tgctatcaaa gaagcctttc
    13321 ctgaagtaga agtgattgca ggaactgcaa cagcagggat tccacacgga gccattattg
    13381 ctgataagat gaacttgcct tttgcctaca tccgtagcaa accaaaagac cacggagctg
    13441 gtaatcaaat cgaaggtcgc gtagctcaag gtcaaaaaat ggtagtggtt gaagacctta
    13501 tttcaacggg tggttcagtt cttgaagctg tagcagcagc caagcgagaa ggagcagatg
    13561 tacttggagt tgtagcgatt ttcagctacc aattgccaaa agcagataag aactttgcag
    13621 atgctggtgt taaacttgtg acgctttcaa actatagcga gcttatccat ctagcccaag
    13681 aagaaggtta catcacgcca gagggccttg atcttctaaa acgctttaaa gaagaccaag
    13741 aaaattggca agaaggttag gtcagtaaga taaagagaga cgaggctacc gagcctcttt
    13801 taccatttta tttaaaatat gacaatattt taaataaaat aattgacaac gctttctttt
    13861 attgatataa tgaaaatgta atatgtatca aattgatcaa tcaactatct tgtttatcac
    13921 ttcttaagag gacgatgtca tgaaaagaag aaaaatatat tccttttttg cgtagttaca
    13981 attgcatcta gtttgtttct ccctacagtt ttagctagac agattggaaa ttatgattta
    14041 acgttgccgc gttggggttc ggatacaact agtgagcttg agaaagaaaa cgcctctgct
    14101 ggaattaata atagtgacag cactggtggc ggtaaaaggt taagtacctc tattcgtagc
    14161 gcctatagtg ggtcagatat taccccggta tattcattgg ggtctggctc taggattgtc
    14221 atgtactata atggaggtgg tgacaattat attggttctg gtactagatt agctatggcg
    14281 ccacaatttg gaaatcatgt aagaattcat acttcaggtt cttggagtcc agattcttat
    14341 taacttactt gtcagagtaa gccttaaaga tggttgattg tgggtgtagc atgaaaaaag
    14401 aatgctacac cctattttta ttataaggag gagtaaggat ggaatttttc atttgtaatc
    14461 ttgtacgagt cgttcaatca cctcgatttt atatgtcttt atttttgacc cttctttgca
    14521 tgagtttagg aaatttcctt gctttcaatg gtatttataa aattgaaggt ttatcgattt
    14581 tttttgccgc ttcttctatt cgaggatttt caccgattag cctagtagct gcacttatct
    14641 gtacactgcc ctattctagt cagataatag aggatgctga gagtcatttt ctaacagcac
    14701 aattgtgccg aatttctaaa aagaggtatc tagctattgt aggtagtact gcaattattt
    14761 cttcttttct agtctttttt ctcccctatt tattattatt aggaattaat cttttagtga
    14821 ctccttatca ggaaatttat attggagatt atagtggtgc cttaaaagaa ttatttgatt
    14881 ctaatcagtt gctctatagt cttgtggcga ctctttggta tggagtttgg ggcgctgtgt
    14941 tctctatttt tggactagct agtgctttgc tagtgaagaa aaaaatagga gctattttca
    15001 tcccagttac ctatatgatg gttggtggta ttttttgggc tattttaggg ctatcttact
    15061 tagaacctgt gacaacatta gctttgggat atcagaaaga tatcagtctt tccttagtta
    15121 gtgggcatct tgcttttatt ttatttgtta gttgtttggt tgtttatggt acattttttc
    15181 tacattcaga ggactatgta taatgaaaca atttgttcaa ttttataaaa aagatttctt
    15241 agcagtattg gtttatttta tattactgct atcctgtgtt ttatctagta cagtatattt
    15301 attgcgctgt cgccaatatt caatccatcc aaatgtatta gaatggattt tagttttact
    15361 tcaagatatg acgactggag tatattgctt tccgttcaca tatatattgt tcttttttta
    15421 tttgatgaat aactatttta ataggttgga gtgtcgcatt cgtctgaaat caattaagca
    15481 ctttaccagt tttagtttca aattagcagc tcttagtacg gggatttgga cggcgacttt
    15541 atttttattg atttttctaa ttgcatttag taatggtttt agcttctctt tggagataaa
    15601 ggaggttgat tttttaggag aattttatgg tataagtatt gcaaacaatg ctagtttctt
    15661 tataggattt tttttctctt atatagcata ctatttcttt ttatccttac ttactattag
    15721 cagtttttct tggtttaaaa aatcaaacat gagcttagta tttctgttta cttttttatt
    15781 tgtagaatcc ttattctgga tttatcagtt gaacaatggg ataattggat tattgccaat
    15841 ttttcagtat atggtaaatt ccaatccgta tgcattgatt tattggctta cattactatc
    15901 tatcataatt ccattgactg tattttctgt tcatagaaac tggaggagag tgtaaaagtt
    15961 ggaaatggga aagttaagta gtcacatgtg gaggttgaat cagataatct ataccaagta
    16021 cttttggggt tatgttcttt tttggatatt gatttgttta ggattatggt attggttaga
    16081 aggaaatgat agacttgtta tagaaatttt aaaagggcct aatctgagtc aaaactcttt
    16141 tttagtctta tctatatggt tgcttcattg gtttattatt catacatttt ttctagcagt
    16201 tgtatatcgt agaagagcat ccgatttctt tatggaagtg attcgatttt cttctattaa
    16261 gctctggatt aggtatcaga tttggacctg ttttctttat ggactcattt taatcatggt
    16321 aaaagttcta gtgattcaat ttatgttaca gttagcaaac tgggatatag gagttttgtt
    16381 tatagttgat tctttgaatg cttgtgtgct atccttgctt tgctttatgt tatacgcact
    16441 aggagcgaat gtacaaatga actttgcttg cgttagtttc tttttactca tgattgtgtt
    16501 tggtggtcta tttgtaggaa atcgaactaa ttatctattt tatattttga atcgagggaa
    16561 tggagatata ggacgagatt tatttcttca gttgctattt ttagtctttc tttttaaaag
    16621 cattttctat ttcactcgtc aaaagaggag gtttatagaa tgaatgaaat aattacatta
    16681 aaaaatattg agttgaaatt aaaaaaaaca tgtgtttttc aaaaccttaa ttttagttgt
    16741 aaacaggggg aaattatagg aattactggt gcgaatggct caggtaaaag tgtattgttt
    16801 aaattaatag ctggtttata tagtccgtct tatggagaag tgttaatcaa tggggaaaat
    16861 attgttcctg agagaaaaat tccagctaat ttgggagctt tgattgaaga acctggtttt
    16921 ataaattatt atagtggctt taagaattta caatatttgg caagcatacg aggagtagtt
    16981 ggtaatcagg aaatcaatga tacactgaaa atagttggtc tatatgagca aaaagaccag
    17041 aaagttaaaa cttattcgct aggtatgagg aaaaagctag ggattgctca agcaattatg
    17101 gagaatccct ctattctttt actagatgaa cctatgaatg ccttggataa atcaagtgta
    17161 gaaaatatga gaacattgtt tagagagctc tctagtgaaa aagggacaac aattttgatt
    17221 gctagtcata gtgaagagga tattcgtatc ttatgtgata aagtatatgc aatagaagat
    17281 aaagtatgta cactgtgttc agattgaaca tcttagatag actcaggatg ttataggtaa
    17341 aatcttaaaa agggattgga gcttaaaatc cagtcccttt taagagttaa tggccacctt
    17401 caacaaccag gtcatctgct ttagcagcgt caccgtaggt tgggtgaagt gttttttcat
    17461 aggccttgtg gaagaagttt tccttgccta atttttcaat atctttattg atgaagtcta
    17521 gcaattcttg gttgtctttt tgaactgctg ccgcaatggt atcgggatca ccgagggaag
    17581 taattcctac ttcaaatcct ttattttcaa gcgcccaagc tagaacttcc gtattgtcag
    17641 ttgaaaaggc atctccacgt ccgtcaagaa gagcttggta agagtcactg tattggtcgt
    17701 atttttggag tttgatttct ggatgattct tttcaaaata agtctcagca gtcgttcctt
    17761 ttgtgacaat taaggtttta ccttcaagtt gtttgacgtc tgtaatgaga ccagtcttag
    17821 gtgatacgac acccagagaa actttcatat atggaagggc aaaatcaact tgtttcttac
    17881 gttcgtcagt tactgtaaag ttagcaagag taatatctac cttgtttgaa atcaagtatt
    17941 ccgcacggtt ggcggcatcg actgaaatgt atttaacctt gacaccaagg tcttgagcta
    18001 gttggttccc tagttcaata tcgtagcgta gccttggtaa gaaccatcat tgtcaacgta
    18061 gccaaacggt tttttatctc caaacacggc gattcgcagt tcaccgcttt ttttgatttc
    18121 atcgatagtg cgagctttgg cagttgtttt tccagaggat gaaccagcgt ttccacctga
    18181 gctacaagca gtgataaaga taagggcaaa ggcaagtgct aaaacagtta agagtggttt
    18241 gaatagtttc ataagaatct cctttataga tatgagccga attggctaaa gtcaaagacg
    18301 tttaaaaatt cctgggctcg tttggtttgc agattggtaa agaaggcttg agctgttcct
    18361 tcttcagcga ttttcccttg gtcgaggaag ataatccggt cagtaatggc ttgggcaaac
    18421 tgcatttcgt gggttactaa aatcatggta cggccttctt gggccaaatc attgataagt
    18481 tccagcacct cacgcaccat ttctggatcc agcgaagcag tcacctcgtc aaaaaggatg
    18541 atttctggat gcattaggag ggcacggaca attgcaacac gttgcttctg tccaccagat
    18601 aattgacggg caaagctatg ttgtttatcc agcaaaccga cacgctctag taattgcaaa
    18661 gcttcttccg ttacttcttt cttgtccctt ccttgagctt tgatagggcc taggatgagg
    18721 ttttgtaaga catccagatg gggaaagagt tcataacttt gaaagaccat gccaatcttt
    18781 tggcgaacta ggtgaaaatc ttttttattt tcaacgatag actgaccatc cagaagaata
    18841 tctccacctt gaatactttc taagccgttg aggcaacgaa ggagggtact tttcccacaa
    18901 ccagatggcc ctaggatgac aacaacttcc cttttttgat ttctagagaa agtccttgga
    18961 ggatgggatt gtctccgaag gattttttta gttccttgat ttctaagata gtttcagaca
    19021 tttagtttct ccaatgtttt tctaagtgag tggatagttt ggaaataggg tagcaaactg
    19081 cgaaatataa gactagaatg gttccataaa tccaaaatga agcagttggg atggtcaggc
    19141 gattgctatc gatgatttgt tgtccaactt tggtcacttc cacaacccca atcaaaacaa
    19201 ctaatgaagt ggttttaatc atccgagtga caagattgat agcctgcggt agcagtcttc
    19261 ttaagacttg tgggatgatg atgtggtagt aaagttgaac attagtcaag ccgagtgcct
    19321 attcactttc aaactgatgt ttagggagag aagtgatagc tccacgtacc aagtctccca
    19381 tttcagctgt tccccagagg gtaaaaatga taatagctga agtctcacct gagatattga
    19441 tattaaagtt tcgagccaag ccaaagtaaa cgatgaagag tagcaccagc tggggcatga
    19501 tacggataaa ttccagatac aatcgtgtta aaaatcgtat gattctagaa tgggaggtca
    19561 tgatgattcc catgactgtt ccgaacatca tggataagag gacagacagg atggatatcc
    19621 caatcgtaac gcccaacccc tgtaagattc tcaggagatt atttccttga aagagtactt
    19681 ggattcccga atcctgcatg gcgggtcctc ctttctatcc agctaaagac cagtgagatg
    19741 ggtagcagca tgatcagata agcaactacc aacatagcta gcgcaatgtc tgtctcatag
    19801 tagagaccaa tcaaatcctt ggcgacgtac atgaggtcgg ccaaagccac tgctgagaaa
    19861 acagaggttt ccttgataag gaaaatgaca ttggcactaa aggaggggag tgccaccgct
    19921 gttgcttgcg gaagaaccac atagcgaaag acctgtagag gtgtcagacc aatagcgagg
    19981 ccaatctcct gctgggtttg actgatggct tccagcccac ttcggaaaga ttctgccata
    20041 taggagcctc ctaaaaagac aagcccaagc gttgcacaga cttctgaaga taggacaatc
    20101 ccgattcggg gaagaccgaa gtagagaaag aagagttgaa tcaaaagggg cgtattacgt
    20161 gacaattcaa tgtaggctgt cgctacttgc gccaaaacag ggattcgata atgtcggatg
    20221 atactaacga ttaaaccgag cagaaaggat cccaaaattc cccaaactgc aatatgcaag
    20281 gtcagaaaga atgccttttg atatagtggt agatattgtt caacaatgga ccaatccaaa
    20341 aatagaacct cccatctaga aataatacag ttattgtagc acttaaaatc ttctttggat
    20401 aatatctatt ttttattgcc gttataagga tttttatcat agacataaaa tttctgaaat
    20461 ttccaaacaa aatattttaa aagttttgaa aaaagagtta agatattttt ataatataca
    20521 aagtaaacgc ttacttatta aggaggacat tttatgtcat acaaaacaag caatgcagaa
    20581 ggtcatgtag atttcatcaa tacctatgat ttggagccaa tggcgcaaca agttattcct
    20641 aaagcagcat ttggctatat cgctagtggg gcggaagata ctttcacttc tttccagtga
    20701 ttttagcgtc aggttctttt tagtttttaa agattatccg tgaatttctt gcttatttat
    20761 gataaaatgg gggtatcgca aaaaatgact catcgtattc aattttgagt aaaactagga
    20821 ggatcccatg tctacagaac atatggaaga actaaatgac cagcagatcg ttcgccgtga
    20881 aaaaatggct gcgctccgcg aacaaggaat cgatcctttc ggaaaacgtt ttgaacgtac
    20941 tgcaaattca caagaattaa aagataaata tgccaacctc gataaagaac aattacacga
    21001 taaaaacgaa acagctacta tcgcaggacg cttggtaacc aaacgtggta aaggtaaagt
    21061 gggttttgcc caccttcaag accgcgaagg ccagattcag atctacgttc gtaaggatgc
    21121 tgtcggtgaa gaaaactacg aaatcttcaa aaaagcagac cttggtgact tccttggtgt
    21181 cgaaggtgaa gtgatgcgta cggatatggg agaactctct atcaaggcaa cccacatcac
    21241 acacttgtct aaggctcttc gtcctcttcc tgagaaattc catggtttga cagacgttga
    21301 aacaatttac cgtaaacgtt accttgactt gatttctaat cgtgaaagct ttgaacgctt
    21361 tgtcactcgt tcaaaaatca tctctgaaat ccgtcgttac cttgaccaaa aaggattcct
    21421 tgaagtggaa acacctgttc ttcataatga agccggtggt gctgctgccc gtccatttat
    21481 cacccaccac aatgcccaaa acattgacat ggtgcttcgt atcgcgactg agcttcactt
    21541 gaaacgcctt attgtgggtg gtatggaacg tgtctatgaa attggccgta tcttccgtaa
    21601 cgaaggaatg gacgctactc ataaccctga gttcacttct atcgaagttt accaagctta
    21661 tgcagacttc caagacatca tggacttgac tgaaggcatt atccaacacg ctgctaaatc
    21721 agtcaaaggt gatggcccag tcaactacca aagtactgaa atcaagatta acgaaccatt
    21781 taagcgtgtt catatggtgg atgctatcag agaaattact ggtgtcgatt tctggcaaga
    21841 catgactttg gaagaagcta aagctatcgc tgctgagaag aaagttccag ttgagaaaca
    21901 ctacactgag gttggtcaca tcatcaatgc cttctttgaa gagtttgttg aagaaacttt
    21961 aatccaacca acctttgtct atggacatcc agtagctgta tctccactcg ctaagaaaaa
    22021 tcctgaagac caacgcttta ctgaccgttt cgagctcttt atcatgacta aggagtacgg
    22081 taatgccttt actgagttga acgacccaat cgaccaactt agccgttttg aagcccaagc
    22141 taaagccaaa gaacttggtg atgatgaagc gacaggaatc gactatgact acattgaagc
    22201 tcttgaatac ggtatgccac caacaggtgg tttgggaatc ggtatcgacc gtctctgcat
    22261 gctcctcact gatacaacaa ctatccgtga tgtattgctc ttcccaacaa tgaaataaat
    22321 tcttatcctc tggctcttac cagaggattt tttgattcaa aaagagactg aatttaagga
    22381 gaaaatgaag tgtagtatat tgaagttgaa atagtacact ttgatttcta agacattgtt
    22441 agaaattggt ttaaattccc taagcaattt gtgcatgttt tatttcattt tacgatagta
    22501 cgctgaaact tttcaaaaag tactagaaat tgacttggat tccccaattg atttgttcag
    22561 attcactata aataaaaaat taataagtgg gataggaagt tagcgtcaac taggatagta
    22621 tcttgcttaa acagtatata tgggactgat ataagtccat aggtcctatt agaggatgtt
    22681 ctggtgtctt attcacttgt ttttttatag tattagtaga tagaatcagc aaataaaaaa
    22741 gtagttcaaa tgcctggcag caaaaaatct caacgattca cttaatatag actaaggttt
    22801 agagtttaag gaaagtaggg ctagtatatt gtatgaaaaa ataagatggt ttttaagcaa
    22861 aactcttgaa aatgattgaa aaaagagtta ttatagttgt atagtaaaaa gcaaacgctt
    22921 acttaatcga ggaggacagt ttatgtcata caaaacaagc aatgcagaag gtcatgtaga
    22981 cttcatcaat acctatgatt tggagccaat ggcgcaacaa gttattccta aagcagcatt
    23041 tggctatatc gctagtgggg cggaagatac tttcacttta agagagaata tccgtgcctt
    23101 taaccacaag ctcatcgttc ctcatacact ttgcaatgta gaaaatccaa atacagagat
    23161 tgaatttgca ggtgaaaaac tatcttctcc aatcattatg gcacctgttg cggctcataa
    23221 attggcaaat gaacaggggg aagtggcgac tgcgcgtggt gtgcatgagt ttggttctct
    23281 ttatacaacc agttcttact ctactgttga ccttccagag atttctgaag cccttcaagg
    23341 gacacctcat tggtttcaat tttactttag taaggatgac ggtatcaacc gccacatcat
    23401 ggaccgtgtg aaggctgaag gttataaagc gattgtcttg acggcagatg ctactgtagg
    23461 ggggaatcgt gaagtggata agcgtaatgg ttttgtcttc ccagttggca tgccgattgt
    23521 tgaagaatac ctgccagaag gtgctggtaa atcaatggac tttgtttaca aatcagctaa
    23581 acaacgcttg tctccacgcg atgtagaatt tatcgctgaa tactctggtc ttcctgtgta
    23641 tgtcaaggga ccacaatgcc gtgaggacgt tgaacgttcg cttgctgcag gagcttctgg
    23701 tatctgggta accaaccacg gtggtcgtca aatcgacggt ggaccagctg cctttgactc
    23761 gcttcaagaa gtggcagaag cagttgatag acgtgtgccg attgtctttg actctggtgt
    23821 tcgtcgtggt caacacgtct ttaaagcctt ggcatcagga gcagacttgg ttgctattgg
    23881 acgccctgtc atctatggct tggctctcgg tggtagtgtc ggtgtgcgtc aagtctttga
    23941 acacttgaat gcggaattga agacagttat gcaattgtct ggagctcaga ccattgaaga
    24001 tgtcaaacac ttcaagctcc gtcacaatcc atacaaccca accttcccag ttgaccctcg
    24061 tgacttaaaa ttgtattgat aaaacagatt gcctccactg aatgtggagg tttttcttcg
    24121 tgtattggaa gaataaattg ctatcgaaaa ctatagtaaa atgaaataag aataggacaa
    24181 atcaatcagg acagtcaaat cgatttctaa caatgtttta gaagtagagg tgtactattc
    24241 tagtttcaat ctactatata aagatatttt tcggtcaaat atcttgctag ggctttcatt
    24301 ttttgctata ctggttcagt aattaaataa tagagacatt tggggtgctt taagctgaga
    24361 tgatacccat tgaacctgat acagttaaga ctggcgaagg gaaatgtgaa acgttttttc
    24421 gtatggcgaa atgaacgatc taatcttgta agtcaactct aattcttgat tgtaattgga
    24481 gttttttgtt tatataaact ggataggctt gtttagttag ctctctgcaa atgctctcga
    24541 tgtgctttaa aaggatcaag tggaattacg attttgcttg atatttcttg gtgttttatt
    24601 aattactaac aagtaaagag aggagaagta aatatggaaa cacaagacta tgcatttcag
    24661 ccaggtttga ctgttggaga attattaaaa agcagtcaga aggattggca ggctgcaatc
    24721 aatcatcgtt ttgttaagga actttttgcg gggacaattg agaataaggt cttaaaggac
    24781 tatctgattc aagattatca cttctttgat gccttcttat ccatgctggg tgcctgcgta
    24841 gctcacgcag ataaacttga atccaagctt cgttttgcca agcaactagg ctttcttgaa
    24901 gcagatgaag atggttattt ccaaaaggct tttaaagagt taaaagtagc agagaatgac
    24961 tatctagaag tgactttgca ccctgtaaca aaagcctttc aggatctaat gtattcggcg
    25021 gtggcttcat cagactatgc ccatcttttg gtcatgctgg tcattgcaga aggtctctat
    25081 ttagactggg gttctaaaga tttggcttta cctgaagtct atattcattc ggaatggatc
    25141 aatctccaca gaggtccttt ctttgcagag tgggttcaat ttctggttga cgaactcaat
    25201 cgtgtcggta aaaatcgaga agatttgaca gaacttcagc aacgctggaa tcaagcagtc
    25261 gctttagaat tagctttttt tgatattggt tacgatgtct agagaaggct catgatattt
    25321 acaaatttga tgaggtaaga ctcttcgaaa atctcttcaa accacgtcag ttctatccac
    25381 aacctcaaaa cagtgttttg agcaacctgc ggttagcctc ctagtttgct ctttgatttt
    25441 cattgagtat aaatcattca atgtaaatga aaaaaattct taacgaaaga tagaaataaa
    25501 tcgaaatcag tagatcgtat aaagtgaaaa ggaaggattt caatatgaca agtttaaaat
    25561 tattaaaaga aaaagcacca ttggtcattt gtataaccaa tgatgtagta aaaaatttca
    25621 cagcaaatgg attagtagca ctgggcgcct caccagccat gagtgagttt ccagcagatt
    25681 tagaggattt gttaaagtat gctggtggtt tattaataaa cataggaaca ttgacagatg
    25741 aaaattggaa attataccaa gctgctctga aaattgcaga gaaatataat gtcccagcag
    25801 ttttagatcc tgtagcctgt ggagcaggag aatatagaaa aaaagtagca gatgatctaa
    25861 tcaacaatta taaactagca gcgattagag gaaatgctgg cgagattgcc tctttagtag
    25921 gaatagatgt ggcatctaaa ggagtagata gtgcgggcgt agataatatt gacgaaattg
    25981 ctctagcagc aaatgagaag ttcaatattc caatagtagt aacaggtgaa gtggatgcca
    26041 ttgctgttaa tggagaagtg gtaacgattc ataatggtag tgctatgatg ccgaaagtca
    26101 ttgggacagg atgcttatta ggggcagtga tagcaagctt tatcggacta gaaaaaggtc
    26161 aagaattgaa atcattagaa acagcaatgt tggtttacaa tatcgctgga gaaatggcag
    26221 aaaaacgtcc aaatggacat cttcctggga catttaaagt tgaatttata aatgccttat
    26281 acgagattac agatgaagat gtaaaggaat tcaaaagagt gaagtaagat gtttcataaa
    26341 gaattactaa aactatattt tatttgtgga acgactactt gccaaggaaa aaatctatat
    26401 acagtcgtta aggaagcctt aaaaggtggt ataaccttat ttcaatttcg agaaaaaggt
    26461 gagggtgctt tagaaggctt agaaaaactt gaactagcta tccaaattaa agaactttgt
    26521 aaaaaataca atgtgccgtt tatcgttaat gatgatatcg atttggcaat ggaaattgac
    26581 gctgatggcg tacatgtagg tcaagatgat attggtgttg atgaaattag aaaattgatg
    26641 ccagataaaa taattggtct ttctataaaa aacgaggaag aatttcaaca atcaaaagtt
    26701 gaatatgtag attatgttgg tgttggtcct gtatttgata cccagtcaaa ggatgatgct
    26761 ggtggtgcta taggttatga aggtcttgaa ttgatgagaa aactattgcc acaaatgcct
    26821 ttagttgcaa ttggtgggat acagacgaaa catattaaag acattataaa gaccaatgtt
    26881 gacggcgttt caatcatttc ggcaatatcg tatgcaaaaa atatagaaaa aactgttcgg
    26941 gaaatgagtg aacaatagat atctatcctt ggattctaag taagtaggat tttccttttt
    27001 taaaaagcta tgtctagatt cagcttgaat agctaattca tcaaacaggt catttgtttt
    27061 ttgcaaaaga aagatctgct gtctttgtga gtgcaaggct gtatttccag ttcaatttct
    27121 tgaactagta taaaatgtgt gttataataa tcacataatt aaataataaa ggcatttggg
    27181 gtgctttagg ctgagatgat acccattgaa cctgatacag ttaagactgg cgaagggaaa
    27241 tgtgaaatgt ttttttcgta tgtcgaaaag aactgtctaa tcttgtaagc tgaactctaa
    27301 ttcgtatctg taattagagt tttttctttt acgaaactgg atgaagatga tatagtagat
    27361 tgaaataaga tgcgaacaaa tcaattagaa aattcaaatt aatttctaga aatattttag
    27421 cattcttgtg tactgttcta aattcagtct gctatacaaa gtatttaggt cggtcttctt
    27481 gagtgcccca cttttcttta aaaaaggagt tttttatgtt gaaaaaatgg cagttaaaag
    27541 atgttatctt gcttgctttc ttgtctatct tttttggtgg ggttttcgtt ggttcaggat
    27601 atgtgtataa tattctcagt ctactcttaa cacctcttgg tttgcaggcc tttgccaatg
    27661 aaatcctctt cggtctctgg tgtatggctg cgcccattgc tgccatcttt gttccgagag
    27721 tcggaagtgc aacgattgga gaagtgctag ctgcgcttgc tgaagtcctt tatggtagcc
    27781 aatttggtct aggagctctt ttgtctggct tggttcaagg tttgggaagt gaatttggtt
    27841 ttatcgtaac taagaatcgc tatgaaagtt ggctctctct aactgctaat agtattggga
    27901 ttacgcttgt tagctttgtc tatgaataca ttaagttagg ttactacgcc ttttcccttc
    27961 cgtttgtcct ttccttactt gtggtacgtt ttatttctgt ttatttcttc tgtaccatct
    28021 tggttcgcgc cattgtcaaa ctctatcatc agtttgcaac tggaggaaaa gcatagatgg
    28081 gtctggaact acgagcgatt cagtccccaa tcttctctga gccgtttgat tttacttttc
    28141 atgcgcaagc ctttaccttg ttagttggga gcagtggttc aggaaaatcc agcctttttc
    28201 aagtcattgc tcaagtcagt tctcttccct atagtggtca agtcctgata gatgggagcg
    28261 aggtcagtca actttctatc atcgcacgtg tccagaaggt tggcattctc tttcaaaatc
    28321 ccaatcatca atttaccatg gagagcttgt ttgaggagct gattttcacc ttggagaata
    28381 tcggctatca ccttcaggaa attgattcta aaatagcaga ggttgtccag caatgtcgtt
    28441 gcgaggcaat cttacaccgt cccattcatc acctatcagg tggggaaaag caaaaagcag
    28501 cgctggctgt cctctttgcc atgaatccta gggtctatct cttggatgaa ccttttgctt
    28561 ccattgaccg caagagcaga atcgagatat tggagattct aaaagagttg gctcttgatg
    28621 ggaagacagt tattttgtgc gaccatgatt tatctgacta taaagcctat atcgaccata
    28681 tggttgagct aagagacgga aaactaaggg aaataaatca aatcccttcc tatgagatga
    28741 cacaggttgc ttcaaaggaa gttgcttcta gcccggaact attccatatg aaccgtgtga
    28801 ctggtgagct tggtaatcgc cccctctttt caattgctga tttcacattc tatcaaggga
    28861 tttcctgtat cctgggtgac aatggtgtcg ggaaatcaac cctctttcgg tctattcttc
    28921 aatttcaaaa gtataagggg cgcattgcat ggaaggggac agtcctgaaa aagaaaaaga
    28981 gtttgtaccg tgatctgacg ggtgttgttc aggaagctga gaagcagttt atccgagtca
    29041 gtctgcgaga ggagcttcaa ttagatggac ctgattctga aagaaatcag cggatttttc
    29101 aagctttacg atattttgat ttggagcagg cagtcgataa gagtccctat caattaagtg
    29161 gtggtcagca aaaaattctt cagctcctga ccatcttgac cagtaaggct tccgtgatct
    29221 tgctagatga accttttgca ggtttggatg atagagcctg ccattatttt tgcaagtgga
    29281 ttgtggagga gaggaatcaa ggaagaagtt ttctgctcat tagtcatcgt ttagaccctt
    29341 tgatttctgt ggttgattat tggattgaga tgactagtca gggtcttcgg catgtgaaag
    29401 aagtgaccat taccaaacca cttacatctc agagtagcaa tacccaaggg gaggtgagat
    29461 agtatggtca aagtagcaac ccagacaccg attatcagtc tcttcttgct gattttatcc
    29521 ttggaaacat ctttcattcc ttcgattgct ctgaatcttt cggtagtcgc attttgtatt
    29581 ctctttatgc tctattaccg tcgatttaaa atgttagctt ggatgatcat acttgccatt
    29641 ttaccatctt ttgccaacta ctgggcagtt cagttacacg gagatgcttc acaggcagtc
    29701 atgcttggaa cgagggcctt tgtgacagtt tgtatcggcc ttgtctttgt ttcctctatt
    29761 tcactaaaag agcttctctt gtacttggct caaaaggggc tatcacgctc ttggtcctat
    29821 gccttgattg tggtattcaa ttcctttcct ctcattcagc aagaaatcaa gtccctcaaa
    29881 gaagcttgcc tattacgtgg tcaagaactg catttttggt cgcccttgat ttacagtaag
    29941 gttctgatga cagtctttag gtggcgccat ctttacctga gagctctgtc tgctcatgga
    30001 tatgacgaac atgcacagtt gaagaatagc tatcggactt tttatattcc taaaaaaaca
    30061 aaattaatct acctgctttt ctttttattg cttcaaacca gtctattttt ataaaggagt
    30121 tattatggaa tttacagata ttgcgatgga attatccaag aaagcttggc aggcttcctt
    30181 tcatcatccc tttattttac aattacaaga ggggaattta gaacctgcca ttttccgcta
    30241 ttacctgatt caggatgcct actatctgaa ggctttctca gaaatctatc atcttttggc
    30301 tgataagact tcaaaccaag agatgaaaag actcttgaaa caaaatgctc agggtttagt
    30361 ggagggtgag ttatttattc gccaacaatt tttcaaggaa ttggaaatca acgaccagga
    30421 aatggagcaa catccaatcg ctccaacctg ttatcattac atttctcata tttataggca
    30481 atttgcagaa ccgaacttag ccatagcttt tgcaagcttg cttccttgtc cttggttata
    30541 ccatgatata ggcaaatcac ttaatcttaa accatcacca aatcctctct atcaacaatg
    30601 gattgaaact tatattacgg atgagttaga gcaacagatc agagaggagg gagcactggt
    30661 caatcagctc tatcgagaaa gtgatgagac agataagcaa aaaatgctag atgccttcca
    30721 catcagtgtt catatggaag ccaagttttg ggaaatggcc taccaacacc agacatggaa
    30781 gagcgattta cagtctttag aaaaaggaga agaatagaag catgagaaag caccaattac
    30841 aagttcacaa attaaccatt ttatctatga tgattgccct tgatgtagtc ctgacaccta
    30901 tctttcggat tgagggaatg gcaccgatgt ccagtgtagt caatattcta gcgggaatca
    30961 tgatgggacc tgtttatgcc ttggccatgg ctacagtgac agcctttatc cgtatgacga
    31021 ctcaagggat tccgccttta gctctcacag gagcgacttt tggagccctt ctagcaggtc
    31081 tcttttataa gtacggtcga aaattttact tttctgcctt gggagaaatt gtgggaacag
    31141 gtattattgg ctctattgtt tcctatcctg ttatggtact ctttacagga tcagctgcta
    31201 agcttagctg gtttatctac acgcctcgat ttttcggagc aaccttgatt ggtacagcga
    31261 tttcctttat tgcctttcga tttttaatca agcaggaatt ctttaaaaaa gtgcagggat
    31321 atttctttag tgaaaggata gactgatgca ggaatttaca aatccctttc ctataggctc
    31381 tagttcccta attcactgta tgaccaatga gatttcttgt gagatgctgg caaatgggat
    31441 tttggctctg ggatgcaaac ctgtcatggc agatgatccc cgtgaagttc ttgattttac
    31501 taagcaaagt caggctctct tcatcaattt ggggcatttg tcagctgaga aggaaaaagc
    31561 aatccgcatg gcagcttcgt atgcaaacca atcttctctc ccgatggtag tagatgcggt
    31621 tggcgtaacg acttcatcca ttcgtaagag cttagttaaa gaccttttag actatagacc
    31681 tacggtcctt aaaggaaaca tgtcagaaat tcgaagtctt gttggcttaa agcaccacgg
    31741 cgttggggtc gatgcgagtg ctaaagatca agaaacggag gatttgcttc aagtcttgaa
    31801 agactggtgt cagacctatc ctggtatgtc tttcttagtt actggcccca aggaccttat
    31861 tgtttcggag aatcaagttg ctgtactgga gaatggctgt actgaattag actggataac
    31921 agggacagga gacttggttg gagccttaac agccgttttt ctcagccaag gaaagactgg
    31981 ttttgaagct tcttgcttag cagtctctta tctcaatatc gctgctgaga aaatagttgt
    32041 tcaaggaatg ggattggaag aatttcgtta ccaagtactc aatcagcttt cgctcctaag
    32101 aagagatgaa aattggctag ataccatcaa aggagaggtt tatgaataga gaagcactta
    32161 gactatatct ggtaaccaat cgctatcaag attccgtgga aagctttctt gcaaaagttg
    32221 agacggcctg ccgttcaggg gttaccatag tccaattgcg agaaaaaaat ctcacaacca
    32281 atcaatatta tcaactggca aaacaagtca aggaaataac agatgcctat caggtcccct
    32341 tgataatcga tgatcggttg gatgtttgtc ttgcggttga tgctgctggt ctgcatattg
    32401 gagatgacga actcccagtt tcggttgccc gacaagtctt gggtcctgaa aaaatcctcg
    32461 gtgtcaccgc taaaacggtt aaaagagctc tggaagcgga gaaatcaggt gcagattact
    32521 tggggacagg agccattttt ccgacaacca ccaaggaaaa tgcacccatc accctgattt
    32581 caaccttgaa aacaatttgc caaacggttg ccattccaat agttgctatt ggtggcttga
    32641 cttcggagaa tattgatcag cttatgggca ctggcatagc tggtgtagct gttgtacgtg
    32701 atttgatgca agcagaagat attgaggcaa aaacgcaagc ctttttaaca aagttgcatg
    32761 acattctttc ctaattaata ctcaatgaaa atcaaagagt aaactagaaa gctagtcgca
    32821 ggttgctcaa agtactgcct tgaggtttta gataagactg acgaagtcag ctcaaaacag
    32881 tgttttgaag ttgcagatgg aagctgacgt agtttgaaga gattttcgaa gagtataaaa
    32941 actctctaat tcccttaaag tgggaactag agagtttttt tcttaatctt taaaagttgt
    33001 atggttgact ggaccagaac catgaccgag ttgaggggca tcttgaatag cttttgtgat
    33061 aaaggccttg gccttatcaa ctgcctggta aagactcttg cccttggcta gttcagcagt
    33121 aatcactgca gcaaaggtac atccagtacc atgggtgtga caggtttgaa ttcgtgggct
    33181 ttcccagaca aattgttcat tcttggtaaa gaggaaatct ttagcaccac ctttgagatg
    33241 tccgcctttg ataaccacag actgaggacc aaattctttt aaaatcaggc gaccagcacg
    33301 ctgcatgtct tcggggtcat ggattgaaaa accaacaatc tcttctgctt caggaagatt
    33361 tggcgtaata atagttgcta gaggtagtaa gtttgttttg agatagtctc tagcacttga
    33421 gtcaatcaag gcatctccac ttgtagcaac cataacagga tcaaggacat agggacaatc
    33481 cagtttttta agatagggtt ggatgatttc catgatttca gtagtagcca acattccagt
    33541 ttttacagcc tgaggtggaa tatcagaaaa gacactctcc aattgggctt tcaacatttg
    33601 aggagaaacg tgctcgatta gctgaacacc tctggtattt tgagcgacaa gactggttac
    33661 aacagccatt ccatagacat ctctcgcttg gaatgacttt aaatctgcca taatgccagc
    33721 accaccacta gggtcagtcc ctgcaatggt caaagcaacg ggtaaataag tcatctaaaa
    33781 cctcccaacc aactgaagtt tgtattctta agaacaagct agtctgtttt agaaaggcaa
    33841 tagaagactg ctagtcccca ttatcatttc cacttccatc agctagcatt acctagattg
    33901 agtcagaggg atctaacagt cgttaatctc agctttacgc acccctagtg gttgttttct
    33961 tttttcttta gtatagcata tttttattgt ttatatagta atatttgact gcaaatcgtt
    34021 tttcaaatga ttaaaattct atttttcgaa gaaaatatta tttctataat tgacaaatgt
    34081 agattttaag agtatactga tgagtgtaat tgacaaatgt agattttgga ggtatggtaa
    34141 tgcagatttc agatgcagaa tggcaggtca tgaagattat ttggatgcag ggggagcaga
    34201 ccagtacgga tttgattagg gttttggcag agcgatttga ttggtccaag tccacggttc
    34261 agacactttt ggctcggctg gttgagaaag agtgtttgac tcggaaaaaa gaaggcaagt
    34321 cctttgttta ttcagccctt ttaactctag accaaagtcg ggatttactt gtccaagata
    34381 tcaaagacaa ggtttgttcc cgtaggatta ggaatttgtt ggctgacttg attgtagaat
    34441 gtgaatttac tcagactgac ttggaagact tggaagctgt gatttcagag aagaaatcaa
    34501 gtgctgtaac agaagtaaga tgtaattgta tgtaaaggag acgtcatgtt aaatagtatt
    34561 gtaaccatta tttgtattgc ccttatcgcg tttatcttgt tttggttttt caaaaagcct
    34621 gaaaaatctg gacaaaaagc ccagcaaaaa aacggatacc aagagattcg agtggaagtc
    34681 atgggaggct atactcctga gttgattgtc ctcaagaaat cagtgccagc acgcattgtc
    34741 tttgaccgca aggatccttc accatgtctg gatcaaattg tttttccaga ttttggtgta
    34801 catacgaacc tgccaatggg ggaagagtat gtagtggaaa tcacgcctga gcaggctgga
    34861 gagtttggct ttgcttgtgg tatgaacatg atgcacggca agatgattgt agagtaggtg
    34921 gagactatga cagaaattgt gaaagcaagc ttagaaaatg gcattcaaaa aatccgtatc
    34981 cgagctgaaa aaggctatca tccagcccat atccagcttc aaaagggaat tccagctgag
    35041 attacctttc atcgtgctac tccttcaaac tgttataagg aaattctgtt tgaagaagaa
    35101 ggtatcttgg aaccaatcgg cgtagatgag gagaaagtca ttcgttttac acctcaagaa
    35161 ttagggcgac atgaattttc ttgtggcatg aagatgcaaa agggaagcta tatagtcgtt
    35221 gagaagactc gaaaatctct atctctcctg caacgttttt ggattactag tatctttact
    35281 gtgcctcttg tgattctcat gattgggatg ttggcaggta gcattagtca tcaagtcatg
    35341 cattggggaa cctttttagc aacaacgcct attatgttag ttgcaggtaa gccatatatc
    35401 cagagtgctt gggccagttt taaaaagcac aatgccaaca tggatacctt ggttgcgctg
    35461 ggaactctag tggcttattt ctatagccta gttgctctct ttgctggtct ccctgtttac
    35521 ttcgaaagtg ctggatttat cctctttttc gttcttttgg gagcagtttt tgaggaaaaa
    35581 atgagaaaaa atacgtccca agctgtggag aaattactgg acttgcaagc taaaaccgca
    35641 gaagtcttga gtgatgatag ttatgtccaa gttcctttgg aacaagtcaa ggtaggcgac
    35701 ctgattcgag tgcgtcccgg tgaaaagatt gctgttgatg gtgtcgtagt agaaggtgtc
    35761 tctagtattg acgaatccat ggtgacaggt gagagtctgc ctgtggacaa gacagttgga
    35821 gatactgtca ttggctcaac catcaatcat agtggaacgc ttgtctttag agcagaaaaa
    35881 gttggctcag agactgtttt ggctcagatt gtggattttg tgaagaaagc tcagacaagt
    35941 cgtgcgccga ttcaggactt gacggataag atttcaggga tttttgtccc agtagttgtc
    36001 attttaggaa tcatgacctt ttgggtttgg ttcgtcttgc tcagggatag tgtggtcgtg
    36061 cttggagcta gctttgtgtc ctctcttctc tacggagtgg cggttttgat tatcgcctgt
    36121 ccttgtgcct tgggacttgc aacaccgaca gcccttatgg tggggacagg acgtagtgcc
    36181 aagatggggg ttctcctcaa aaatggaact gtcttacagg aaatccagaa agttcaaact
    36241 cttgtctttg ataagaccgg gactttgacg gaagggaaac ctgtggtaac agatatcatc
    36301 ggcgacgaag tagaagtgtt tggattggca gcctccttgg aagatgcttc tcaacaccca
    36361 ctggctgagg ctatcgttaa gcgagcgagt gaagctggac ttgagtttca aactgttgaa
    36421 aattttcagg ccttgcacgg gaaaggtgtt tcagggcgag tcaatggaaa acaagtttta
    36481 cttggaaatg ctaaaatgct ggatggcatg gatatttcta atacttatca agataaacta
    36541 gaagaactag aaaaagaagc taagacagtt gtgtttttag ctgttgacaa tgaaatcaaa
    36601 ggcttgcttg ctttgcaaga tattcctaag gaaaatgcta agctagccat cagtcagcta
    36661 aaaaaacgtg gtctccgaac agtcatgctg acaggagaca atgctggtgt ggcgcgtgct
    36721 attgcagatc aaatcggaat tgaagaggtc attgcaggcg tcttgccaga agaaaaagcc
    36781 catgaaatcc ataaactgca agcggctggc aaagtagcct ttgttgggga cggtatcaat
    36841 gacgctcctg cccttagtgt agcagatgtg ggaattgcta tgggtgctgg aacagatatc
    36901 gccatcgagt cagcagattt ggtgttgaca accaataatc ttttaggagt ggttcgtgcc
    36961 tttgatatga gtaagaaaac ctttcatcga attctactca atcttttctg ggcttttatc
    37021 tacaatgttg tcggaattcc gattgcagca ggagtctttt caggtgttgg actggctctc
    37081 aacccagaat tggcaggtct agccatggcc tttagttctg tatctgttct gaccagttcc
    37141 cttctgttaa attttagtaa aatagactaa aagtaatgac tagatttctt tgttataaaa
    37201 cagaaatgac aacactttca aaactgtatt agaatagaga atagagagtt ttgagcagat
    37261 ttttagaaaa gtcagcataa atatgataca gtggaatagt aaaaatttgg agaacgtttc
    37321 caattctatg taatcgtatt ctccaagttt aaaaaaattg aaggagagtt atcattatga
    37381 ctcaagggaa aattactgca tctgcagcaa tgcttaacgt attgaaaaca tggggcgtag
    37441 atacaatcta cggtatccca tcaggaacac tcagctcatt gatggatgct ttggctgaag
    37501 acaaagatat ccgtttctta caagttcgcc acgaagagac aggtgctctt gcagcggtta
    37561 tgcaagctaa attcggcggc tcaatcgggg ttgcagttgg ttcaggtggt ccaggtgcga
    37621 ctcacttgat taacggtgtt tacgatgcag ctatggataa cactccattc ctagcgatcc
    37681 ttggatcacg tccagttaac gaattgaaca tggatgcttt ccaagagctt aatcaaaacc
    37741 caatgtacaa cggtatcgct gtttacaaca aacgtgtagc ttacgctgag caattgccaa
    37801 aagtaattga cgaagcctgc cgtgctgcag tttctaaaaa aggtccagct gttgttgaaa
    37861 ttccagtaaa cttcggtttc caagaaatcg atgaaaactc atactacggt tcaggttcat
    37921 acgaacgctc attcatcgct cctgctttga acgaagttga aatcgacaaa gctgttgaaa
    37981 tcttgaacaa tgctgaacgc ccagttatct atgctggatt tggtggtgtt aaagctggtg
    38041 aagtgattac tgaattgtca cgtaaaatca aagcaccaat catcacaact ggtaaaaact
    38101 ttgaagcttt cgaatggaac tatgaaggtt tgacaggttc tgcttaccgt gttggttgga
    38161 aaccagccaa cgaagtggtc tttgaagcag acacagttct tttccttggt tcaaacttcc
    38221 cattcgctga agtttacgaa gcattcaaga acactgaaaa atttatccaa gtcgatatcg
    38281 acccttacaa acttggtaaa cgtcatgctc ttgacgcttc aatccttggt gatgctggtc
    38341 aagcagctaa agctatcctt gacaaagtaa acccagttga atcaactcca tggtggcgtg
    38401 caaacgttaa gaacaaccaa aactggcgtg attacatgaa caaactcgaa ggtaaaactg
    38461 agggtgaatt gcaattgtat caagtttaca atgcaatcaa caaacatgct gatcaagacg
    38521 ctatctactc aatcgacgta ggtaacacta ctcaaacatc tactcgtcac cttcacatga
    38581 cacctaagaa catgtggcgt acatctccac tctttgcgac aatgggtatt gcccttcctg
    38641 gtggtatcgc tgctaagaaa gacaatccag atcgccaagt atggaacatc atgggtgacg
    38701 gagcattcaa catgtgctac ccagacgtta tcacaaacgt tcaatacgac cttccagtta
    38761 tcaaccttgt cttctcaaat gctgagtacg gcttcatcaa gaacaaatac gaagatacaa
    38821 acaaacactt gtttggtgta gacttcacaa acgctgacta cgctaaaatt gcggaagctc
    38881 aaggagctgt tggattcaca gttgaccgta tcgaagacat cgatgcagtt gttgcagaag
    38941 ctgttaaatt gaacaaagaa ggtaaaactg ttgtcatcga tgctcgcatc actcaacacc
    39001 gtccacttcc agtagaagta cttgaattgg atccaaaact tcactcagaa gaagctatca
    39061 aagccttcaa ggaaaaatac gaggcagaag aactcgtacc attccgtctc ttcttggaag
    39121 aagaaggatt gcaatcacgc gcaattaaat aattcctctc gccgaaaatc aaatatgaaa
    39181 cttgtagact ttattctttg attttcatag agcagaactt taaaagatcg gagcaatccg
    39241 gtctttttat ggaggagagt aaatgaattt aaatcaatta gatattatcg tttcaaatgt
    39301 tccccaagtc tgtgctgact tggagcatat cttggataaa aaggcagatt atgctgatga
    39361 tggttttgct cagtttacga ttggtagtca ctgccttatg ttgtcacaaa atcatttggt
    39421 tcctttggaa aactttcagt caggaatcat tattcatatc gaggttgagg atgtagacca
    39481 gaactacaaa cggttgaacg agcttggtat aaaggtttta cacggaccaa ctgtaaccga
    39541 ttggggaaca gagtccttat tagttcaagg acctgctggt ctagtgcttg atttttatcg
    39601 tatgaaatag gtcgcgtagt catttgacgt taaccttagc tatttttaaa atagaaattg
    39661 agaatatgaa ctattgaaag atcggagcaa tccggtcttt ttatataaag aaattgcata
    39721 taatactcat ctgctttcaa aaagcattct agtccatctc cgattaacga tggactttat
    39781 cacctccttc tccagtcctt gtatgacatc ttgaagttga tt
//
LOCUS       DAVLHC010000017        34630 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.017, whole genome shotgun sequence.
ACCESSION   DAVLHC010000017 DAVLHC010000000
VERSION     DAVLHC010000017.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 34630)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 34630)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..34630
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.017"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            622..1074
                     /locus_tag="VXE25_000960"
     CDS             622..1074
                     /locus_tag="VXE25_000960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000587452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhcH/YjgK/YiaL family protein"
                     /protein_id="HEV0771440.1"
                     /translation="MIITKISRLGTYVGVNPHFATLIDFLEKTGLENLTEGSIAIDGN
                     RLFGNCFTYLADGQAGDFFETHQKYLDIHLVLENEEAMAVTSPENVSVTQEYDEEKDI
                     ELYTGKVEQLVHLRAGECLITFPEDLHQPKVRINDEPVKKVVFKVAIS"
     gene            1093..2430
                     /locus_tag="VXE25_000961"
     CDS             1093..2430
                     /locus_tag="VXE25_000961"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000738772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="HEV0771441.1"
                     /translation="MKKMRKFLCLAGIALAAVALVACSGKKEATTSTEPPTELSGEIT
                     MWHSFTQGPRLESIQKSADAFMQKHPKTKIKIETFSWNDFYTKWTTGLANGNVPDIST
                     ALPNQVMEMVNSDALVPLNDSIKRIGQDKFNETALNEAKIGDDYYSVPLYSHAQVMWV
                     RTDLLKEHNIEVPKTWDQLYEASKKLKEAGVYGLSVPFGTNDLMATRFLNFYVRSGGG
                     SLLTKDLKADLTSQLAQDGIKYWVKLYKEISPQDSLNFNVLQQATLFYQGKTAFDFNS
                     GFHIGGINANSPQLIDSIDAYPIPKIKESDKDQGIETSNIPMVVWKNSKHPEVAKAFL
                     EALYNEEDYVKFLDSTPVGMLPTIKGISDSAAYKENETRKKFKHAEEVITEAVKKGTA
                     IGYENGPSVQAGMLTNQHIIEQMFQDIITNGTDPMKAAKEAEKQLNDLFEAVQ"
     gene            2509..3393
                     /locus_tag="VXE25_000962"
     CDS             2509..3393
                     /locus_tag="VXE25_000962"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEV0771442.1"
                     /translation="MVKERNLTRWIFVLPAMIIVGLLFVYPFFSSIFYSFTNKHLIMP
                     NYKFVGLANYKAVLSDPNFFNAFFNSIKWTIFSLVGQVLVGFVLALALHRVRHFKKLY
                     RTLLIVPWAFPTIVIAFSWQWILNGVYGYLPNLIVKLGLMEHTPAFLTDSTWAFLCLV
                     FINIWFGAPMIMVNVLSALQTVPEEQFEAAKIDGASSWQVFKFIVFPHIKVVVGLLVV
                     LRTVWIFNNFDIIYLITGGGPANATTTLPIFAYNLGWGTKLLGRASAVTVLLFIFLVA
                     ICFIYFAIISKWEKEGRK"
     gene            3393..4226
                     /locus_tag="VXE25_000963"
     CDS             3393..4226
                     /locus_tag="VXE25_000963"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016250560.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HEV0771443.1"
                     /translation="MKKKSSIYLDILSHVLLVGATIVAIFPLVWIIISSVKGKGELTQ
                     YPTRFWPEQFTLDYFTHVINDLHFIDNIRNSLIIALATTLIAIIISAMAAYGIVRFFP
                     KLGAIMSRLLVITYIFPPILLAIPYSIAIAKVGLTNSLFGLMMVYLSFSVPYAVWLLV
                     GFFQTVPIGIEEAARIDGANKFVTFYKVVLPIVAPGIVATAIYTFINAWNEFLYALIL
                     INNTGKMTVAVALRSLNGSEILDWGDMMAASVIVVLPSIIFFSIIQNKIASGLSEGSV
                     K"
     gene            4244..6337
                     /gene="nanB"
                     /locus_tag="VXE25_000964"
     CDS             4244..6337
                     /gene="nanB"
                     /locus_tag="VXE25_000964"
                     /EC_number="3.2.1.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001042179.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="neuraminidase NanB"
                     /protein_id="HEV0771444.1"
                     /translation="MNKRGLYSKLGISVVGISLLMGVPTLIYANELNYGQLSISPIFQ
                     GGSYQLNNKSIDISPLLLDKLSGESQTVVMKFKADKPNSLQALFGLSNSKAGFKNNYF
                     SIFMRDSGEIGVEIRDAQKGINYLFSRPASLWGKHKGQAVENTLVFVSDSKDKTYTMY
                     VNGIEVFSETVDTFLPISNINGIDKATLGAVNREGKEHYLAKGSIDEISLFNKAISDQ
                     EVSNIPLSNPFQLIFQSGDSTQANYFRIPTLYTLSSGRVLSSIDARYGGTHDSKSKIN
                     IATSYSDDNGKTWSEPIFAMKFNDYEEQLVYWPRDNKLKNSQISGSASFIDSSIVEDK
                     KSGKTILLADVMPAGIGNNNANKADSGFKEINGHYYLKLKKNGDNDFRYTVRENGVVY
                     DETTNKPTNYTINDKYEVLEGGKSLTVEQYSVDFDSGSLRERHNGKQVPMNVFYKDSL
                     FKVTPTNYIAMTTSQNRGESWEQFKLLPPFLGEKHNGTYLCPGQGLALKSSNRLIFAT
                     YTSGELTYLISDDSGQTWKKSSASIPFENATAEAQMVELRDGVIRTFFRTTTGKIAYM
                     TSRDSGETWSEVSYIDGIQQTSYGTQVSAIKYSQLIDGKEAVILSTPNSRSGRKGGQL
                     VVGLVNKEDDSIDWKYHYDIDLPSYGYAYSAITELPNHHIGVLFEKYDSWSRNELHLS
                     NVVQYIDLEINDLTK"
     gene            6349..7452
                     /locus_tag="VXE25_000965"
     CDS             6349..7452
                     /locus_tag="VXE25_000965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000241731.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="HEV0771445.1"
                     /translation="MVKYGVVGAGYFGAELARYMQKNDGAEITLLYDPDNAEAIAEEL
                     GAKVASSLDELVSSDEVDCVIVATPNNLHKEPVIKAAQHGKNVFCEKPIALSYQDCRE
                     MVDACKENNVTFMAGHIMNFFNGVHHAKELINQGVIGDVLYCHTARNGWEEQQPSVSW
                     KKIREKSGGHLYHHIHELDCVQFLMGGMPETVTMTGGNVAHEGEHFGDEDDMIFVNME
                     FSNKRFALLEWGSAYRWGEHYVLIQGSKGAIRLDLFNCKGTLKLDGQESYFLIHESQE
                     EDDDRTRIYHSTEMDGAIAYGKPGKRTPLWLSSVIDKEMRYLHEIMEGAPVSEEFAKL
                     LTGEAALEAIATADACTQSMFEDRKVKLSEIVK"
     gene            7626..8324
                     /locus_tag="VXE25_000966"
     CDS             7626..8324
                     /locus_tag="VXE25_000966"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398897.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmannosamine-6-phosphate 2-epimerase"
                     /protein_id="HEV0771446.1"
                     /translation="MPQISKEALIEQIKDGIIVSCQALPHEPLYTEAGGVIPLLVKAA
                     EQGGAVGIRANSVRDIKEIKEVTKLPIIGIIKRDYPPQEPFITATMKEVDELAELDIE
                     VIALDCTKRERYDGLEIQEFIRQVKEKYPNQLLMADTSIFEEGLAAVEAGIDFVGTTL
                     SGYTSYSPKVDGPDFELIKKLCDAGVDVIAEGKIHTPEQAKQILEYGVRGIVVGGAIT
                     RPKEITERFVASLK"
     gene            8343..9860
                     /locus_tag="VXE25_000967"
     CDS             8343..9860
                     /locus_tag="VXE25_000967"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000477452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HEV0771447.1"
                     /translation="MFKVLQKVGKAFMLPIAILPAAGLLLGIGGALSNPTTIATYPIL
                     DNSIFQSIFQVMSSAGEVVFSNLSLLLCVGLCIGLAKRDKGTAALAGVTGYLVMTATI
                     KALVKLFMAEGSAIDTGVIGALVVGIVAVYLHNRYNNIQLPSALGFFGGSRFVPIVTS
                     FSSILIGFVFFVIWPPFQQLLVSTGGYISQAGPIGTFLYGFLMRLSGAVGLHHIIYPM
                     FWYTELGGVETVAGQTVVGAQKIFFAQLADPAHSGLFTEGTRFFAGRFSTMMFGLPAA
                     CLAMYHSVPKNRRKKYAGLFFGVALTSFITGITEPIEFMFLFVSPVLYVVHAFLDGVS
                     FFIADVLNISIGNTFSGGVIDFTLFGILQGNAKTNWVLQIPIGLIWSVLYYIIFRWFI
                     TQFNVLTPGRGEEVDSKEISESADSTSNTADYLKQDSLQIIRALGGSNNIEDVDACVT
                     RLRVAVKEVNQVDKALLKQIGAVDVLEVKGGIQAIYGAKAILYKNSINEILGVDD"
     gene            9985..11313
                     /locus_tag="VXE25_000968"
     CDS             9985..11313
                     /locus_tag="VXE25_000968"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000672126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter substrate-binding
                     protein"
                     /protein_id="HEV0771448.1"
                     /translation="MKFRKLACTVLAGAAVLGLAACGNSGGSKDAAKSGGDGAKTEIT
                     WWAFPVFTQEKTGDGVGTYEKSIIEAFEKANPDIKVKLETIDFKSGPEKITTAIEAGT
                     APDVLFDAPGRIIQYGKNGKLAELNDLFTDEFVKDVNNENIVQASKAGDKAYMYPISS
                     APFYMAMNKKMLEDAGVANLVKEGWTTDDFEKVLKALKDKGYTPGSLFSSGQGGDQGT
                     RAFISNLYSGSVTDEKVSKYTTDDPKFVKGLEKATSWIKDNLINNGSQFDGGADIQNF
                     ANGQTSYTILWAPAQNGIQAKLLEASKVEVVEVPFPSDEGKPALEYLVNGFAVFNNKD
                     DKKVAASKKFIQFIADDKEWGPKDVVRTGAFPVRTSFGKLYEDKRMETISGWTQYYSP
                     YYNTIDGFAEMRTLWFPMLQSVSNGDEKPADALKAFTEKANETIKKAMKQ"
     gene            11565..12431
                     /locus_tag="VXE25_000969"
     CDS             11565..12431
                     /locus_tag="VXE25_000969"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001209417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEV0771449.1"
                     /translation="MRETVISYAFLAPVLFFFVIFVLAPMVMGFITSFFNYSMTKFEF
                     VGLDNYIRMFKDPVFTKSLINTVILVIGSVPVVVLFSLFVASQTYHQNVIARSFYRFV
                     FFLPVVTGSVAVTVVWKWIYDPLSGILNFVLKSSHIISQNISWLGDKNWALMAIMIIL
                     LTTSVGQPIILYIAAMGNIDNSLVEAARVDGATEFQVFWKIKWPSLLPTTLYIAIITT
                     INSFQCFALIQLLTSGGPNYSTSTLMYYLYEKAFQLTEYGYANTIGVFLAVMIAIVSF
                     VQFKVLGNDVEY"
     gene            12447..13286
                     /locus_tag="VXE25_000970"
     CDS             12447..13286
                     /locus_tag="VXE25_000970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398901.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HEV0771450.1"
                     /translation="MQSTEKKPLTAFTVISTIILLLLTVLFIFPFYWILTGAFKSQPD
                     TIVIPPQWFPKMPTMENFQQLMVQNPALQWMWNSVFISLVTMFLVCATSSLAGYVLAK
                     KRFYGQRILFAIFIAAMALPKQVVLVPLVRIVNFMGIHDTLWAVILPLIGWPFGVFLM
                     KQFSENIPTELLESAKIDGCGEIRTFWSVAFPIVKPGFAALAIFTFINTWNDYFMQLV
                     MLTSRNNLTISLGVATMQAEMATNYGLIMAGAALAAVPIVTVFLVFQKSFTQGITMGA
                     VKG"
     gene            13559..14011
                     /locus_tag="VXE25_000971"
     CDS             13559..14011
                     /locus_tag="VXE25_000971"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000575445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhcH/YjgK/YiaL family protein"
                     /protein_id="HEV0771451.1"
                     /translation="MIFDDLKNITFYKGIHPNLDKAIDYLYQHRRDSFELGKYEIDGD
                     KVFLVVQENVLNQVENNQFEHHKNYADLHLLIEGHEYSSYGSRIKEEAVAFDEASDIG
                     FVHCYEHYPLLLGYHNFAIFFPGEPHQPNGYAGMEEKVRKYLFKILID"
     gene            14108..14452
                     /locus_tag="VXE25_000972"
     CDS             14108..14452
                     /locus_tag="VXE25_000972"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000254916.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771452.1"
                     /translation="MVSSKYAARASFLDGQGITVDEMSWIIRGIVNGLIGRYIKLGTY
                     AAKYGISMARSILSRAAATAAARVGLLTKIFGWILRIAVLAADVYGNFANNIAVAWDA
                     HDKIPNNGRINF"
     gene            14739..15383
                     /locus_tag="VXE25_000973"
     CDS             14739..15383
                     /locus_tag="VXE25_000973"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000057467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YesL family protein"
                     /protein_id="HEV0771453.1"
                     /translation="MAQKGVSLIKAAFDTDNFLMRFSEKVLDIVTANLLFVVSCLPIV
                     TIGVAKISLYETMFEVKKSRRVPVFKIYLRSFKQNLKLGLQLGLMELGIVFLTLSDLY
                     LFWGQTALPFQLLKAICLGILIFLTIVMLASYPIAARYDLSWKEILQKGLMLASFNFP
                     WFFLMLAILVLIVMVLYLSAFSLLLGGSVFLLFGFGLLVFIQTGLMEKIFAKYQ"
     gene            15552..16469
                     /locus_tag="VXE25_000974"
     CDS             15552..16469
                     /locus_tag="VXE25_000974"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002894436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="HEV0771454.1"
                     /translation="MSDLKKYEGVIPAFYACYDDQGEVSPERTRALVQYFIDKGVQGL
                     YVNGSSGECIYQSVEDRKLILEEVMAVAKGKLTIIAHVACNNTKDSMELARHAESLGV
                     DAIATIPPIYFRLPEYSVAKYWNDISSAAPNTDYVIYNIPQLAGVALTPSLYTEMLKN
                     PRVIGVKNSSMPVQDIQTFVSLGGEDHIVFNGPDEQFLGGRLMGARAGIGGTYGAMPE
                     LFLKLNQLIADKDLETARELQYAINAIIGKLTSAHGNMYGVIKEVLKINEGLNIGSVR
                     SPLTPVTEEDRPVVEAAAALIRETKERFL"
     gene            16487..17371
                     /locus_tag="VXE25_000975"
     CDS             16487..17371
                     /locus_tag="VXE25_000975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HEV0771455.1"
                     /translation="MTYYVAIDIGGTNIKYGLVDQEGQLLESHEMPTEAHKGGPHILQ
                     KTKDIVASYLEKGPVAGVAISSAGMVDPDKGEIFYAGPQIPNYAGTQFKKEIEESFTI
                     PCEIENDVNCAGLAEAVSGSGKGASVTLCLTIGTGIGGCLIMDRKVFHGFSNSACEVG
                     YMHMQDGAFQDLASTTALVKYVAEAHGEDVDQWNGRRIFKEATEGNKICMEGIDRMVD
                     YLGKGLANICYVANPEVVILGGGIMGQEAILKPKIRTALKEALVPSLAEKTRLEFAHH
                     QNTAGMLGAYYHFKTKQS"
     gene            complement(17387..18238)
                     /locus_tag="VXE25_000976"
     CDS             complement(17387..18238)
                     /locus_tag="VXE25_000976"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HEV0771456.1"
                     /translation="MDKPDIATIIDSHFEEMTDLEQEIARYFLQAETITDDLSSQQVT
                     QKLHISQAALTRFAKKCGFTGYREFIFQYQHQAENQANQVSKHSPLTKRVLRSYSNMR
                     EQTQDLIDEIQLERIAQLIEDAERIYFFGTGSSGLVAREMKLRFMRLGVVCEALTDQD
                     GFAWTTSIMDENCLVLGFSLSGSTPSILDSLLDAKEMGAKTVLFTSVPNKDSQTYTET
                     VLVATHSQPSYIQRISAQLPMLFFIDLIYAYFLEINRESKEKIFNSYWENKKLNGYRR
                     QKRVRKS"
     gene            18438..20495
                     /gene="pbp2b"
                     /locus_tag="VXE25_000977"
     CDS             18438..20495
                     /gene="pbp2b"
                     /locus_tag="VXE25_000977"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein 2B"
                     /protein_id="HEV0771457.1"
                     /translation="MRLICMRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNK
                     DFYEKKLASASQTKITSSSARGEIYDASGKPLVENTLKQVVSFTRSNKMTATDLKETA
                     KKLLTYVSISSPNLTERQLADYYLADPEIYKKIVEALPSEKRLDSDGNRLSESELYNN
                     AVDSVQTSQLNYTEDEKKEIYLFSQLNAVGNFATGTIATDPLNDSQVAVIASISKEMP
                     GISISTSWDRKVLETSLSSIVGSVSSEKAGLPAEEAEAYLKKGYSLNDRVGTSYLEKQ
                     YEETLQGKRSVKEIHLDKYGNMESVDTIEEGSKGNNIKLTIDLAFQDSVDALLKSYFN
                     SELENGGAKYSEGVYAVALNPKTGAVLSMSGIKHDLKTGELTPDSLGTVTNVFVPGSV
                     VKAATISSGWENGVLSGNQTLTDQSIVFQGSAPINSWYTQAYGSFPITAVQALEYSSN
                     TYMVQTALGLMGQTYQPNMFVGTSNLESAMEKLRSTFGEYGLGTATGIDLPDESTGFV
                     PKEYSFANYITNAFGQFDNYTPMQLAQYVATIANNGVRVAPRIVEGIYGNNDKGGLGD
                     LIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGTSGLTTGRAFSNGALVSISGKTGTA
                     ESYVADGQQATNTNAVAYAPSDNPQIAVAVVFPHNTNLTNGVGPSIARDIINLYQKYH
                     PMN"
     gene            20506..21102
                     /gene="recR"
                     /locus_tag="VXE25_000978"
     CDS             20506..21102
                     /gene="recR"
                     /locus_tag="VXE25_000978"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002896112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombination protein RecR"
                     /protein_id="HEV0771458.1"
                     /translation="MLYPTPIAKLIDSYSKLPGIGIKTATRLAFYTIGMSADDVNEFA
                     KNLLSAKRELTYCSICGRLTDDDPCSICTDPTRDQTTILVLEDSRDVAAMENIQEYHG
                     LYHVLHGLISPMNGISPDDINLKSLMTRLMDSEVSEVIVATNATADGEATSMYLSRLL
                     KPAGIKVTRLARGLAVGADIEYADEVTLLRAIENRTEL"
     gene            21278..22321
                     /locus_tag="VXE25_000979"
     CDS             21278..22321
                     /locus_tag="VXE25_000979"
                     /EC_number="6.3.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000814683.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--D-alanine ligase"
                     /protein_id="HEV0771459.1"
                     /translation="MKQTIILLYGGRSAEREVSVLSAESVMRAVDYDRFTVKTFFISQ
                     SGDFIKTQEFSHAPGQEDRLMTNETIDWDKKVAPSAIYEEGAVVFPVLHGPMGEDGSV
                     QGFLEVLKMPYVGCNILSSSLAMDKITTKRVLESAGIAQVPYVAIVEGDDVTAKIAEV
                     EEKLAYPVFTKPSNMGSSVGISKSENQEELRQALKLAFRYDSRVLVEQGVNAREIEVG
                     LLGNYDVKSTLPGEVVKDVAFYDYDAKYIDNKITMDIPAKISDDVVAVMRQNAETAFR
                     AIGGLGLSRCDFFYTDKGEIFLNELNTMPGFTQWSMYPLLWDNMGISYPELIERLVDL
                     AKESFDKREAHLI"
     gene            22405..23778
                     /locus_tag="VXE25_000980"
     CDS             22405..23778
                     /locus_tag="VXE25_000980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000778684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-
                     alanine ligase"
                     /protein_id="HEV0771460.1"
                     /translation="MKLTIHEIAQVVGAKNDISIFEDTQLEKAEFDSRLIGTGDLFVP
                     LKGARDGHDFIETAFENGAAVTLSEKEVSNHPYILVDDVLTAFQSLASYYLEKTTVDV
                     FAVTGSNGKTTTKDMLAHLLSTRYKTYKTQGNYNNEIGLPYTVLHMPEGTEKLVLEMG
                     QDHLGDIHLLSELARPKTVIVTLVGEAHLAFFKDRSEIAKGKMQIADGMASGSLFLAP
                     ADPIVEDYLPTDKKVVRFGQGAELEITDLVERKDSLTFKANFLEQVLDLPVTGKYNAT
                     NAMIASYVALQEGVSEEQIRLAFQHLELTRNRTEWKKAVNGADILSDVYNANPTAMKL
                     ILETFSAIPANEGGKKIAVLADMKELGDQSVQLHNQMILSLSPDVLDIVIFYGEDIAQ
                     LAQLASQMFPIGHVYYFKKTEDQDQFEDLVKQVKESLGAYDQILLKGSNSMNLAKLVE
                     SLENEAK"
     gene            23765..24376
                     /locus_tag="VXE25_000981"
     CDS             23765..24376
                     /locus_tag="VXE25_000981"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HEV0771461.1"
                     /translation="MKPSDFVKYLQRMIALTDTGLTFTKDPFDRERYEDLRSLLSEML
                     NQGSDLDVEEVAEVLKPTSAYATPLMDVRAWIVEDEKICLVRGQGEDSWALPGGFGEV
                     GYSPTENILKEIEEETGFKAKVERLLAVFDTNRFQLQSKQYAKFVFECKLLDGQFQEN
                     QEIADLQFFAIDQLPNLSEKRITKEQIEILWQVYQGQREQYLD"
     gene            24467..25171
                     /locus_tag="VXE25_000982"
     CDS             24467..25171
                     /locus_tag="VXE25_000982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001055242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR02206 family membrane protein"
                     /protein_id="HEV0771462.1"
                     /translation="MNLWDIFFTTQATEPPKFDLFWYVSLFTLLALTFYTAHRYREKK
                     VYQRFFQILQTVQLILLYGWYWVNHMPLSESLPFYHCRMAMFVVLLLPGQSKYKQYFA
                     LLGTFGTLAAFVYPVPDAYPFPHVTILSFIFGHLALLGNSLVYLLRQYNARLLDVKGI
                     FLMTFALNALIFVVNLVTGGDYGFLTKPPLVGDHGLVANYLLVSIVLVATISLTKKIL
                     EFFLAQEAEKMIAKEA"
     gene            25390..26763
                     /gene="ftsA"
                     /locus_tag="VXE25_000983"
     CDS             25390..26763
                     /gene="ftsA"
                     /locus_tag="VXE25_000983"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000090410.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsA"
                     /protein_id="HEV0771463.1"
                     /translation="MAREGFFTGLDIGTSSVKVLVAEQRNGELNVIGVSNAKSKGVKD
                     GIIVDIDAAATAIKSAISQAEEKAGISIKSVNVGLPGNLLQVEPTQGMIPVTSDTKEI
                     TDQDVENVVKSALTKSMTPDREVITFIPEEFIVDGFQGIRDPRGMMGVRLEMRGLLYT
                     GPRTILHNLRKTVERAGVQVENVIISPLAMVQSVLNEGEREFGATVIDMGAGQTTVAT
                     IRNQELQFTHILQEGGDYVTKDISKVLKTSRKLAEGLKLNYGEAYPPLASKETFQVEV
                     IGEVEAVEVTEAYLSEIISARIKHILEQIKQELDRRRLLDLPGGIVLIGGNAILPGMV
                     ELAQEVFGVRVKLYVPNQVGIRNPAFAHVISLSEFAGQLTEVNLLAQGAIKGENDLSH
                     QPISFGGMLQKTAQFVQSTPVQPAPAPEVEPVAPTEPMADFQQASQNKPKLADRFRGL
                     IGSMFDE"
     gene            26780..28039
                     /gene="ftsZ"
                     /locus_tag="VXE25_000984"
     CDS             26780..28039
                     /gene="ftsZ"
                     /locus_tag="VXE25_000984"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000144288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsZ"
                     /protein_id="HEV0771464.1"
                     /translation="MTFSFDTAAAQGAVIKVIGVGGGGGNAINRMVDEGVTGVEFIAA
                     NTDVQALSSTKAETVIQLGPKLTRGLGAGGQPEVGRKAAEESEETLTEAISGADMVFI
                     TAGMGGGSGTGAAPVIARIAKDLGALTVGVVTRPFGFEGSKRGQFAVEGINQLREHVD
                     TLLIISNNNLLEIVDKKTPLLEALSEADNVLRQGVQGITDLITNPGLINLDFADVKTV
                     MANKGNALMGIGIGSGEERVVEAARKAIYSPLLETTIDGAEDVIVNVTGGLDLTLIEA
                     EEASQIVNQAAGQGVNIWLGTSIDESMRDEIRVTVVATGVRQDRVEKVVAPQARSATN
                     YRETVKPAHSHGFDRHFDMAETVELPKQNPRRLEPTQASAFGDWDLRRESIVRTTDSV
                     VSPVERFEAPISQDEDELDTPPFFKNR"
     gene            28044..28715
                     /locus_tag="VXE25_000985"
     CDS             28044..28715
                     /locus_tag="VXE25_000985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YggS family pyridoxal phosphate-dependent
                     enzyme"
                     /protein_id="HEV0771465.1"
                     /translation="MNVKENTELVFREVAEASLSAHRESGSVSVIAVTKYVDVPTAEA
                     LLPLGVHHIGENRVDKFLEKYEALKDRDVTWHLIGTLQRRKVKDVIQYVDYFHALDSV
                     KLAGEIQKRSDRVIKCFLQVNISKEESKHGFSREELLEILPELARLDKIEYVGLMTMA
                     PFEASSEQLKEIFKAAQDLQREIQEKQIPNMPMTELSMGMSRDYKEAIQFGSTFVRIG
                     TSFFK"
     gene            28725..29264
                     /locus_tag="VXE25_000986"
     CDS             28725..29264
                     /locus_tag="VXE25_000986"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000053379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein SepF"
                     /protein_id="HEV0771466.1"
                     /translation="MSLKDRFDRFIDYFTEDEDSSLPYEKRDEPVFTSVNSSQEPALP
                     MNQPSQSAGTKENNITRLHARQQELANQSQRATDKVIIDVRYPRKYEDATEIVDLLAG
                     NESILIDFQYMTEVQARRCLDYLDGACHVLAGNLKKVASTMYLLTPVNVIVNVEDIRL
                     PDEDQQGEFGFDMKRNRVR"
     gene            29264..29527
                     /locus_tag="VXE25_000987"
     CDS             29264..29527
                     /locus_tag="VXE25_000987"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000576515.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YggT family protein"
                     /protein_id="HEV0771467.1"
                     /translation="MIFLIRMIYNAVDIYSLILVAFAVMSWFPGAYESSLGRWIVALV
                     KPVLAPLQRLPLQIAGLDLSVWVAIVLVRFLGENLVRFLAMIG"
     gene            29524..30309
                     /locus_tag="VXE25_000988"
     CDS             29524..30309
                     /locus_tag="VXE25_000988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding protein"
                     /protein_id="HEV0771468.1"
                     /translation="MNKGIYQHFSIEDRPFLDKGMEWIKKVEDSYAPFLTPFINPHQE
                     KLLKILAKTYGLACSSSGEFVSSEYVRVLLYPDYFQPEFSDFEISLQEIVYSNKFEHL
                     THAKILGTVINQLGIERKLFGDILVDEERAQIMINQQFLLLFQDGLKKIGRIPVSLEE
                     RPFTEKIDKLEQYRELDLSVSSFRLDVLLSNVLKLSRNQANQLIEKKLVQVNYHVVDK
                     SDYTVQVGDLISVRKFGRLRLLQDKGQTKKEKKKITVQLLLSK"
     gene            30318..31106
                     /gene="divIVA"
                     /locus_tag="VXE25_000989"
     CDS             30318..31106
                     /gene="divIVA"
                     /locus_tag="VXE25_000989"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein DivIVA"
                     /protein_id="HEV0771469.1"
                     /translation="MPITSLEIKDKTFGTRFRGFDPEEVDEFLDIVVRDYEDLVRANH
                     DKNLRIKSLEERLSYFDEIKDSLSQSVLIAQDTAERVKQAAHERSNNIIHQAEQDAQR
                     LLEEAKYKANEILRQATDNAKKVAVETEELKNKSRVFHQRLKSTIESQLAIVESSDWE
                     DILRPTATYLQTSDEAFKEVVSEVLGEPIPAPIEEEPIDMTRQFSQAEMEELQARIEV
                     ADKELSEFEAQIKQEVETPTPVVSPQVEEEPLLIQLAQCMKNQK"
     gene            31454..34246
                     /locus_tag="VXE25_000990"
     CDS             31454..34246
                     /locus_tag="VXE25_000990"
                     /EC_number="6.1.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000768038.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isoleucine--tRNA ligase"
                     /protein_id="HEV0771470.1"
                     /translation="MKLKDTLNLGKTAFPMRAGLPTKEPVWQKEWEDAKLYQRRQELN
                     EGKPHFVLHDGPPYANGNIHVGHAMNHISKDIIIRSKSMSGFNAPYIPGWDTHGLPIE
                     QVLAKQGVKRKEMDLVEYLKLCREYALSQVYKQRDDFKRLGMSGDWENLYVTLTPDYE
                     AAQIRVFGEMANKGYIYRGAKPVYWSWSSESALAEAEIEYHDLVSTSLYYANKVKDGK
                     GILDTDTYIVVWTTTPFTITASRGLTVGADIDYVLVQPAGETRKFVVAAELLTSLSEK
                     FGWADVQVLATYRGQELNHIVTEHPWDTAVDELVILGDHVTTDSGTGIVHTAPGFGED
                     DYNVGIANGLEVAVTVDERGIMMANAGPEFEGQFYDKVVPTVIEKLGNLLLAQEEISH
                     SYPFDWRTKKPIIWRAVPQWFASVSKFRQEILDAIDKVKFHTEWGKVRLYNMIRDRGD
                     WVISRQRAWGVPLPIFYAEDGTAIMTAETIEHVAQLFEVHGSSIWWERDAKDLLPEGF
                     THPGSPNGEFKKETDIMDVWFDSGSSWNGVLVNRPNLTYPADLYLEGSDQYRGWFNSS
                     LITSVANHGVAPYKQILSQGFTLDGKGEKMSKSLGNTIAPSDVEKQFGAEILRLWVTS
                     VDSSNDVRISMDILSQVSETYRKIRNTLRFLIANTSDFNPAQDVVAYDELRSVDKYMT
                     IRFNQLVKTIRDAYADFEFLTIYKALVNFINVDLSAFYLDFAKDVVYIEGAKSLERRQ
                     MQTVFYDILVKITKLLTPILPHTAEEIWSYLEFETEDFVQLSELPEAQTFANQEEILD
                     TWAAFMDFRGQAQKALEEARNAKVIGKSLEAHLTVYPNEVVKTLLEAVNSNVAQLLIV
                     SDLTIAEGPAPEAALSFEDVAFTVERAAGEVCDRCRRIDPTTAERSYQAVICDHCASI
                     VEENFADAVAEGFEEK"
BASE COUNT        10683 a         6098 c         7533 g        10316 t
ORIGIN      
        1 aattccaaat tagaaaaaga cttgaaatac taaaaaaaaa gtatactcta attgaaaacg
       61 gtaacaaaac taatttagag aatgaaatat agagtatttc tctcttaaaa gtttttggtg
      121 aaacgagatg tagaaaggag atttagccaa agagtctatt agtgctagaa taatagatta
      181 gaattatttt agaaaaacga agtgagcagc ttataaattc aagtccccaa atagattcat
      241 actagtatct tttgcaaaaa ataaagggcg acttccttca tgaatatcaa tttcatctat
      301 aaggaaggta gctaattgaa ctaacttatt tattctgttt gtcgctagaa aaatcagacc
      361 tccttgtgaa gattgaggag atacttaatg aaaatcaaag aagaaactag caagctagta
      421 gcagattgcc caaaacaccg ctttgaggtt gtagataaga ctgacgtata taatccaagg
      481 tgaagcgact gtggtttgaa gagattttca aagagtatag actagagagt agtgttttta
      541 tgtccttcta gtagaaaatg ctagacagaa gaatggggaa cttggatagg aaaaatagat
      601 tgagaaagga ggttagaaga gatgattatt acaaaaatta gccgtttagg aacttatgtg
      661 ggagtaaatc cacattttgc aacattaata gattttctag aaaaaacagg actagaaaat
      721 ttaacagaag gttcgattgc tatcgatggt aatcgattgt ttgggaattg ctttacttat
      781 ctagcagatg gtcaagcagg ggatttcttt gaaacacacc aaaaatattt ggatattcat
      841 ttagttttgg aaaacgaaga agccatggct gttacatcgc cggaaaatgt aagcgttacc
      901 caagaatatg atgaagagaa agatattgaa ttatacacag ggaaagtgga acagttggtt
      961 catttgagag ctggtgaatg cctcatcact tttccagaag atttacatca acccaaggtt
     1021 cgtataaatg atgaacctgt gaaaaaagtt gtctttaaag ttgcgatttc ttaatgtaga
     1081 aagagaagaa cgatgaaaaa aatgagaaag tttttatgtc tagctggaat tgcgctagcg
     1141 gctgttgcct tggtagcttg ttcaggaaaa aaagaagcta caactagtac tgaaccacca
     1201 acagaattat ctggtgagat tacaatgtgg cactccttta ctcaaggacc ccgtttagaa
     1261 agtattcaaa aatcagcaga tgctttcatg caaaagcatc caaaaacgaa aatcaagatt
     1321 gaaacatttt cttggaatga cttctatact aaatggacta caggtttagc aaatggaaat
     1381 gtgccagata tcagtacagc tcttcctaac caagtaatgg aaatggtcaa ctcagacgct
     1441 ttggttccgc taaatgattc tatcaagcgt attggacaag ataaatttaa cgaaactgcc
     1501 ttaaatgaag caaaaatcgg agatgattac tactctgttc ctctttattc acatgcacaa
     1561 gtcatgtggg ttagaacaga tttgttaaaa gaacataata ttgaggttcc taaaacttgg
     1621 gatcaactct atgaagcttc taaaaaattg aaagaagctg gagtttatgg cttgtctgtt
     1681 ccgtttggaa caaatgactt aatggcaaca cgtttcttga acttctacgt acgtagtggt
     1741 ggaggaagcc tcttaacaaa agatcttaaa gcagacttga caagccaact tgctcaagat
     1801 ggtattaaat actgggttaa attgtataaa gaaatctcac ctcaagattc tttgaacttt
     1861 aatgtccttc aacaagctac cttgttctat caaggaaaaa cagcatttga ctttaactct
     1921 ggcttccata tcggaggaat taatgccaac agtcctcaat tgattgattc gattgatgct
     1981 tatcctattc caaaaatcaa agagtctgat aaagatcaag gaattgaaac ctcaaacatt
     2041 ccaatggttg tttggaaaaa ttcaaaacat ccagaagttg ctaaagcatt cttagaagca
     2101 ctttataatg aagaagacta cgttaaattc cttgattcaa ctccagtagg tatgttgcca
     2161 actattaagg ggattagcga ttctgcagcc tataaagaaa atgaaactcg taagaaattt
     2221 aaacatgctg aagaagtaat tactgaagct gttaaaaaag gtactgctat tggttatgaa
     2281 aatggaccaa gtgtacaagc tggtatgtta actaaccaac acattattga acaaatgttc
     2341 caagatatca ttacaaatgg aacagatcct atgaaagcag caaaagaagc agaaaaacaa
     2401 ttaaatgatt tatttgaggc tgttcagtag atgtaaaaga ctagaaaata ggtgggctag
     2461 tgagctgaaa agctctagcc caatcttgta aaagaaggga gaaggagaat ggttaaagaa
     2521 cgtaatttaa ctcgctggat atttgttttg ccagctatga ttatcgtagg attactcttt
     2581 gtttatccgt ttttctcgag tattttttat agctttacca ataagcattt gattatgcct
     2641 aattataaat ttgttggttt ggctaactat aaagctgtgc tatcagatcc caacttcttt
     2701 aatgcgttct ttaattcaat taagtggacc attttctcat tagttggtca agttttagta
     2761 gggtttgtat tggctttagc tcttcacaga gtacgccact tcaagaaatt atataggacc
     2821 ttattgattg ttccttgggc atttcctacc atcgtcattg ccttttcttg gcagtggatt
     2881 ctaaacgggg tttatggcta cttacctaat ctaatcgtaa aattaggttt aatggaacat
     2941 acacctgcat ttttgacaga tagtacatgg gcattcctat gtttggtgtt tatcaacatt
     3001 tggtttggag caccaatgat tatggttaat gtgctttcag ctttgcaaac agtaccagaa
     3061 gaacaatttg aggctgctaa gatagatggt gcttcaagtt ggcaggtgtt caagtttatc
     3121 gtctttccac atattaaagt ggttgtagga cttctagttg ttttgagaac tgtatggatc
     3181 tttaataact ttgacattat ctacctcatt actggtggtg gaccagccaa tgctacaacg
     3241 acgcttccaa tttttgctta caacctgggc tggggaacta aattgttggg tcgtgcttca
     3301 gcagttacag tattgctctt tatcttcttg gtggcgattt gctttatcta ctttgctatc
     3361 atcagtaagt gggaaaagga gggtagaaaa taatgaagaa gaaatccagt atttatttag
     3421 atattctctc acatgtactt ttagttggtg cgaccatcgt tgcaattttc ccattggtat
     3481 ggattatcat atcttctgtc aaagggaaag gggaattaac tcagtatcca acacgatttt
     3541 ggcctgaaca gtttacatta gattatttca ctcatgttat caacgatttg cacttcattg
     3601 ataacattcg aaacagttta atcattgcct tggctacaac cctcattgcg attattattt
     3661 ctgctatggc agcctatggt attgttcgat tctttcctaa attgggagca atcatgtcga
     3721 gactactcgt cattacctac attttcccac caattttgtt agcaattccc tattcaattg
     3781 ccattgctaa agttgggtta acaaatagtt tatttggctt gatgatggtt tatctatctt
     3841 ttagtgttcc atatgcagtt tggctcttag ttggattttt ccaaacagtt ccaattggaa
     3901 ttgaagaagc ggctagaatt gatggtgcaa ataaatttgt tacgttttat aaagttgtgc
     3961 taccgattgt agcaccaggt attgtagcaa cagctattta tacatttatc aatgcttgga
     4021 atgaattcct gtatgccttg attttgatta acaatacagg aaagatgaca gtagcagtag
     4081 cccttcgttc acttaatggt tcagaaatac tagactgggg agatatgatg gcagcgtctg
     4141 ttattgtagt tcttccatca attattttct tctctatcat ccaaaataag attgcaagtg
     4201 gattatcaga aggatctgtg aagtagacga aagaaggaaa aaaatgaata aaagaggtct
     4261 ttattcaaaa ctaggaattt ccgttgtagg cattagtctt ttaatgggag tccccacttt
     4321 gatttatgcg aatgaattaa actatggtca actgtccata tctcctattt ttcaaggagg
     4381 ctcatatcaa ctgaacaata agagtataga tatcagccct ttgttattag ataaattgtc
     4441 tggagagagt cagacagtag taatgaaatt taaagcagat aaaccaaact ctcttcaagc
     4501 tttgtttggc ctatctaata gtaaagcagg ctttaaaaat aattactttt caattttcat
     4561 gagagattct ggtgagatag gtgtagaaat aagagacgcc caaaagggaa taaattattt
     4621 attttctaga ccagcttcat tatggggaaa gcataaagga caggcagttg aaaatacact
     4681 agtatttgta tctgattcta aagataaaac atacacaatg tatgttaatg gaatagaagt
     4741 gttctctgaa acagttgata catttttgcc aatttcaaat ataaatggta tagataaggc
     4801 aacactagga gctgttaatc gtgaaggcaa ggaacattac ctcgcaaaag gaagtattga
     4861 tgaaatcagt ctatttaaca aagcaattag tgatcaggaa gtttcaaata ttcccttgtc
     4921 aaatccattt cagttaattt tccaatcagg agattctact caagctaact attttagaat
     4981 accgacacta tatacattaa gtagtggaag agttctatca agtattgatg cacgttatgg
     5041 tgggactcat gattctaaaa gtaagattaa tattgccact tcttatagtg atgataatgg
     5101 gaaaacgtgg agtgagccaa tttttgctat gaagtttaat gactatgagg agcagttagt
     5161 ttactggcca cgagataata aattaaagaa tagtcaaatt agtggaagtg cttcattcat
     5221 agattcatcc attgttgaag ataaaaaatc tgggaaaacg atattactag ctgatgttat
     5281 gcctgcgggt attggaaata ataatgcaaa taaagccgac tcaggtttta aagaaataaa
     5341 tggccattat tatttaaaac taaagaagaa tggagataac gatttccgtt atacagttag
     5401 agaaaatggt gtcgtttatg atgaaacaac taataaacct acaaattata ctataaatga
     5461 taagtatgaa gttttggagg gaggaaagtc tttaacagtc gaacaatatt cggttgattt
     5521 tgatagtggc tctttaagag aaaggcataa tggaaaacag gttcctatga atgttttcta
     5581 caaagattcg ttatttaaag tgactcctac taattatata gcaatgacaa ctagtcagaa
     5641 tagaggagag agttgggaac aatttaagtt gttgcctccg ttcttaggag aaaaacataa
     5701 tggaacttac ttgtgtcccg gacaaggttt agcattaaaa tcaagtaaca gattgatttt
     5761 tgcaacatat actagtggag aactaaccta tctcatttct gatgatagtg gtcaaacatg
     5821 gaagaaatcc tcagcttcaa ttccgtttga aaatgcaaca gcagaagcac aaatggttga
     5881 actgagagat ggtgtgatta gaacattctt tagaaccact acaggtaaga tagcttatat
     5941 gactagtaga gattctggag aaacatggtc ggaagtttcg tatattgatg gaatccaaca
     6001 aacttcatat ggcacacaag tatctgcaat taaatactct caattaattg atggaaaaga
     6061 agcagtcatt ttgagtacac caaattctag aagtggccgt aagggaggtc aattagttgt
     6121 cggtttagtc aataaagaag atgatagtat tgattggaaa taccactatg atattgattt
     6181 gccttcgtat ggttatgcct attctgcgat tacagaattg ccaaatcatc acataggtgt
     6241 actgtttgaa aaatatgatt cgtggtcgag aaatgaattg catttaagca atgtagttca
     6301 gtatatagat ttggaaatta atgatttaac aaaataaagg agaaaaacat ggttaaatac
     6361 ggtgttgttg gagcagggta ttttggagct gaattggctc gctacatgca aaaaaatgat
     6421 ggagcagaga ttactcttct ctatgatcca gataatgcag aggcgattgc agaagaattg
     6481 ggagcaaaag tagcaagttc cttagatgag ttggtttcta gcgatgaagt agactgtgtt
     6541 atcgtcgcaa ctccaaataa tcttcataag gaaccggtta ttaaggctgc acagcatggt
     6601 aaaaatgttt tctgtgaaaa accaattgcg ctttcttatc aagattgtcg cgagatggta
     6661 gatgcgtgta aagaaaacaa tgtaaccttt atggcaggac atattatgaa tttctttaat
     6721 ggtgttcatc atgcaaaaga actcattaat caaggagtta tcggagacgt tctatattgt
     6781 catacagctc gtaatggttg ggaagaacaa caaccgtcag tatcatggaa aaaaattcgt
     6841 gaaaaatcag gtggtcactt gtatcaccac atccatgaat tggattgcgt tcaattcctt
     6901 atggggggca tgcctgaaac tgtaaccatg acaggtggaa atgtggccca tgaaggtgaa
     6961 catttcggtg atgaagatga tatgattttt gtcaatatgg aattttctaa taagcgtttt
     7021 gccttgttag aatggggttc agcttatcgt tggggtgaac attatgtctt aatccaagga
     7081 agcaaaggtg ccatccgctt agacttattc aactgtaaag gaactcttaa gctagatggg
     7141 caagaaagct atttcttgat tcacgaatcg caagaagaag atgatgatcg gactcgtatc
     7201 tatcatagta cagagatgga tggagcaatt gcttatggta aaccaggtaa acgtactcca
     7261 ttatggctat catctgtcat tgataaagaa atgcgctatc tgcatgagat tatggaagga
     7321 gccccagtat cagaagaatt tgcaaaactt ttgacaggtg aagctgccct agaagcaatt
     7381 gctactgcag atgcttgtac ccagtctatg tttgaagatc gcaaagtaaa attgtcagaa
     7441 attgtaaaat aaattttggt attctcctat ttataggtcg acttgctcct ctgaaagtac
     7501 ttttagagga gctgtttgac tttgctagtt tttgaaactg aaatctatta tactacaaac
     7561 tattgaaagc gttttaattt taaggtataa taatctcata gaaataaaga aaaggaggaa
     7621 agaggatgcc acagattagc aaagaagcct tgattgagca aatcaaagat ggaatcatcg
     7681 tttcttgtca ggctcttcct catgaaccgc tttatacaga agcgggaggg gtgattccct
     7741 tgctggtcaa agcggctgag caaggtggag cagtcggtat ccgagcaaac agtgttcgcg
     7801 atatcaagga aattaaggaa gtcactaaac ttccaatcat tgggattatc aaacgtgatt
     7861 atccacctca ggaacccttc atcacggcta ctatgaaaga agttgatgaa ttggcagaac
     7921 tggacatcga ggtgattgct ctggattgta ccaagcgtga acgctacgat ggtttggaaa
     7981 ttcaagagtt cattcgtcag gttaaggaga aatatcctaa tcagcttttg atggctgata
     8041 ctagtatctt cgaagaaggg ctagcagctg tagaagcagg aattgacttt gtcggaacaa
     8101 ccttatcagg ctacacatcc tacagtccaa aagtagacgg tccagatttt gaattgatta
     8161 agaaactctg tgatgccggt gtagatgtca ttgcagaagg aaaaattcat acaccagaac
     8221 aagccaaaca aatccttgaa tatggagtgc gaggcatcgt tgttggtggc gccattacta
     8281 gaccaaaaga gattacagaa cgcttcgttg ctagtcttaa ataagatgtg agagggagtt
     8341 ttatgtttaa agttttacaa aaagttggaa aagcttttat gttacctata gctatacttc
     8401 ctgcagcagg tctacttttg gggattggtg gtgcactttc aaacccaacc acgatagcaa
     8461 cttatccaat actagacaat agtatttttc aatcaatatt ccaagtaatg agctctgcag
     8521 gagaggttgt attcagtaat ttgtcactac ttctctgtgt gggattatgt attggcttag
     8581 cgaaacgaga taaaggaacc gctgcgttag caggagtaac tggttactta gttatgactg
     8641 caacgatcaa agctttggta aaacttttta tggcagaagg atctgcaatt gatactggag
     8701 ttattggagc attagttgtc ggaatagttg ccgtatattt gcacaaccga tataacaata
     8761 ttcaattacc ttccgcttta ggattctttg gaggttcacg cttcgttcct attgttacat
     8821 cgttctcttc tatcttgatt ggctttgtct tctttgttat ttggccacct ttccaacaac
     8881 ttcttgtttc tacaggtgga tatatttctc aggcgggtcc aattggaact tttctatatg
     8941 gatttttaat gagactttct ggagcagtag gcttacatca tataatttac cctatgtttt
     9001 ggtatactga acttggtggt gttgaaactg ttgcaggaca aacagtggtt ggagctcaaa
     9061 aaatattttt tgctcaatta gccgatccgg cccattctgg attatttaca gaaggaacaa
     9121 ggttttttgc aggtcgtttc tcaacaatga tgttcggttt accggctgcc tgtttagcga
     9181 tgtaccatag tgttcctaaa aatcgtcgta aaaaatacgc gggtttgttt tttggagttg
     9241 ctttaacatc ttttattacc ggtattacag aaccaattga atttatgttt ctattcgtca
     9301 gtccggttct atatgttgtt cacgcattcc ttgatggtgt tagcttcttt attgcagacg
     9361 tcttaaatat ttcaatagga aacacatttt caggaggtgt aatcgatttc actttatttg
     9421 gaattttgca ggggaacgct aagacgaatt gggttcttca gattccaatt ggacttattt
     9481 ggagtgtttt gtattatatt atttttagat ggttcattac tcaattcaac gttctaacgc
     9541 caggacgagg agaagaagta gattctaaag aaatttctga atccgcagat tcaacttcaa
     9601 atactgcaga ttatttaaaa caggatagcc tacaaattat cagagccttg ggtggatcaa
     9661 ataatataga agatgtagat gcttgtgtga cacgtttacg tgtagctgta aaagaagtta
     9721 atcaagttga taaagcactt ttaaaacaaa ttggtgcagt tgatgtctta gaagtgaagg
     9781 gtggcattca agcaatatat ggagcaaaag caatcttata taaaaatagt attaatgaaa
     9841 ttttaggtgt agatgattaa gtacttactg acttaataaa aaacagagga gagtgatgga
     9901 tgagtaggat gaaatgaaat cgcatacaag aaataaagaa ctcattatcc aagttggata
     9961 cgcttattac ataggagaat acaaatgaaa tttagaaaat tagcttgtac agtacttgcg
    10021 ggtgctgcgg ttcttggtct tgctgcttgt ggcaattctg gcggaagtaa agatgctgcc
    10081 aaatcaggtg gtgacggtgc caaaacagaa atcacttggt gggcattccc agtatttacc
    10141 caagaaaaaa ctggtgacgg tgttggaact tatgaaaaat caatcatcga agcgtttgaa
    10201 aaagcaaacc cagatataaa agtgaaattg gaaaccatcg acttcaagtc aggtcctgaa
    10261 aaaatcacaa cagccatcga agcaggaaca gctccagacg tactctttga tgcaccagga
    10321 cgtatcatcc aatacggtaa aaacggtaaa ttggctgagt tgaacgacct cttcacagat
    10381 gaatttgtta aagatgtcaa caatgaaaac atcgtacaag caagtaaagc tggagacaag
    10441 gcttatatgt atccgattag ttctgcccca ttctacatgg caatgaacaa gaaaatgtta
    10501 gaagatgctg gagtagcaaa ccttgtaaaa gaaggttgga caactgatga ttttgaaaaa
    10561 gtattgaaag cacttaaaga caagggttac acaccaggtt cattgttcag ttctggtcaa
    10621 gggggagacc aaggaacacg tgcctttatc tctaaccttt atagcggttc tgtaacagat
    10681 gaaaaagtta gcaaatatac aactgatgat cctaaattcg tcaaaggtct tgaaaaagca
    10741 actagctgga ttaaagacaa tttgatcaat aatggttcac aatttgacgg tggggcagat
    10801 atccaaaact ttgccaacgg tcaaacatct tacacaatcc tttgggcacc agctcaaaat
    10861 ggtatccaag ctaaactttt agaagcaagt aaggtagaag tggtagaagt accattccca
    10921 tcagacgaag gtaagccagc tcttgaatac cttgtaaacg gatttgcagt attcaacaat
    10981 aaagacgaca agaaagtcgc tgcatctaag aaattcatcc agtttatcgc agatgacaaa
    11041 gagtggggac ctaaagacgt agttcgtaca ggtgctttcc cagtccgtac ttcatttgga
    11101 aaactttatg aagacaaacg catggaaaca atcagcggct ggactcaata ctactcacca
    11161 tactacaaca ctattgatgg ttttgctgaa atgagaacac tttggttccc aatgttgcaa
    11221 tctgtatcaa atggtgacga aaaaccagcg gatgctttga aagccttcac tgaaaaagca
    11281 aacgaaacaa tcaaaaaagc tatgaaacaa tagtccttag ttattctata aaaagtagtt
    11341 ttttaaagaa cctaagagtg tataccccct tttccctcta cacagatagt gtaagaaaag
    11401 ggggcttttg tttaaaatgt aagaaactgt cacgaaatta aaatgaagtt cttacataag
    11461 cgaatcataa aaaatttcat tttgatttta aaacagttca agaaagtcaa aaaattattc
    11521 tatttgaaag agaggtgccg actgtgaaag tcaataaaat ccgtatgcgg gaaacagtga
    11581 tttcctacgc tttcctagca ccagtattat tcttctttgt catctttgtg ttggctccga
    11641 tggtgatggg cttcattaca agtttcttta actactcaat gactaaattt gagtttgtag
    11701 gcttggataa ctatatccgt atgtttaaag atcctgtctt tacaaaatct ctgattaaca
    11761 cagttatttt ggttattgga tctgtaccag ttgttgttct attctcactc tttgtagcat
    11821 ctcagaccta tcatcaaaat gtcattgcca gatccttcta ccgtttcgtc ttcttccttc
    11881 ctgttgtaac gggtagtgtt gccgtgacag ttgtttggaa atggatttat gacccgctat
    11941 cagggattct aaactttgtc cttaagtcaa gccacatcat cagccaaaac atttcttggt
    12001 tgggagataa aaactgggca ttgatggcga ttatgattat tctcttgacc acttcagttg
    12061 gtcagcccat catcctttat atcgctgcca tggggaatat tgacaattca ctggttgaag
    12121 cggcgcgtgt tgatggtgca actgagtttc aagttttttg gaagattaaa tggccaagcc
    12181 ttcttccaac aactctttat attgcaatca tcacaacaat taactcattc cagtgtttcg
    12241 ccttgattca gcttttgaca tctggtggtc caaactactc aacaagtacc ttgatgtact
    12301 acctttacga aaaagccttc caattgacag aatacggcta tgccaacaca attggtgtct
    12361 tcttggcagt catgattgct atcgtaagct ttgttcaatt taaagtactt ggaaacgacg
    12421 tagaatacta aagaaaggag acagctatgc aatctacaga aaaaaaacca ttaacagcct
    12481 ttactgttat ttcaacaatc attttgctct tgttgactgt gctgttcatc tttccattct
    12541 actggatttt gacaggggca ttcaaatcac aacctgatac aattgttatt cctcctcagt
    12601 ggttccctaa aatgccaacc atggaaaact tccaacaact catggtgcag aaccctgcct
    12661 tgcaatggat gtggaactca gtatttatct cattggtaac catgttctta gtttgtgcaa
    12721 cctcatctct agcaggttat gtattggcta aaaaacgttt ctatggtcaa cgcattctat
    12781 ttgctatctt tatcgctgct atggcgcttc caaaacaagt tgtccttgta ccattggtac
    12841 gtatcgtcaa cttcatggga atccacgata ctctctgggc agttatcttg cctttgattg
    12901 gatggccatt cggtgtcttc ctcatgaaac aatttagtga aaatattcct acagagttgc
    12961 ttgaatcagc taaaatcgac ggttgtggtg agattcgtac cttctggagt gtagccttcc
    13021 cgattgtgaa accagggttt gcagcccttg caatctttac cttcatcaat acttggaatg
    13081 actacttcat gcaattggta atgttgactt cacgtaacaa tttgaccatc tcacttgggg
    13141 ttgcgaccat gcaggctgaa atggcaacca actatggttt gattatggca ggagctgccc
    13201 ttgctgctgt tccaatcgtc acagtcttcc ttgtcttcca aaaatccttc acacagggta
    13261 ttactatggg agcggtcaaa ggataatact ctgcgaaaat cgaatgcaaa ctacgtcagc
    13321 ttcaccttgc catacttaag tattgcctgc ggttagcttc ctagtttgtt cttcaatttt
    13381 cattgagtat aggaaaatca atctatcaag atacagaagt atattttata gatttagaga
    13441 atatagaagt tataagtgtc tacaaaatgg agggtatgca gttactttat gaagttttgt
    13501 cagacactta tcaacttaag aatgatttta gttaattatc agaaacgaag gaaagagtat
    13561 gatttttgac gatttgaaaa acatcacctt ttacaaaggg attcatccca atttagacaa
    13621 ggctatcgac tatctctacc aacatcgtag agattcattc gaattaggaa agtatgagat
    13681 tgatggagat aaagtctttc tagttgttca ggaaaatgtc ctcaatcaag ttgagaataa
    13741 tcaatttgaa caccataaga actatgcaga tttgcatttg ctgatagaag ggcatgaata
    13801 ttcgagctac ggttcacgta tcaaagaaga ggcagtagca ttcgacgaag cgagtgacat
    13861 tggctttgtt cattgttatg aacactaccc actcttattg ggttatcaca attttgcgat
    13921 tttcttccca ggtgagccac atcagccaaa tggttatgca ggcatggaag aaaaggttcg
    13981 aaaatatctc tttaaaatct tgattgatta aaaataggat gaattgtttt tttgtaaagc
    14041 tttgataata ctctaccatg aaattgatct ttgtgaggta gagaaatgag aataaaatat
    14101 ttaaaaattg gtatcttcta agtatgctgc aagagctagt ttcttagatg gacaggggat
    14161 tacagttgat gagatgtcct ggataattag gggcattgtg aatggattga ttggtagata
    14221 cataaaatta ggtacttatg cagctaagta tggtattagt atggcgcgct cgatcttaag
    14281 tagggcagct gcaactgcgg cagcaagagt aggattattg actaagattt ttggatggat
    14341 tttacgaata gctgtgctcg cagctgatgt atatggtaat tttgccaaca atattgctgt
    14401 agcttgggat gcacatgata aaatccctaa caatggtcgt ataaactttt aaaatgcgag
    14461 aatgaaagca ctttgtattt ttttattgaa tatgttagct tggacagtgc ttgcaatgat
    14521 aattcgtgga gggctagatg gatttaatga gcatacttgg agtactattt taattgcttc
    14581 gctgtccggg atatatatag attatatgtc catagataaa agtagaaaaa agtccaaaag
    14641 aaaaaagaaa aaatagattt gttcatggta gggacttatg aaagttttac tgacaaaaaa
    14701 gaaaacagtt tacaaagaaa aatgatggag gagcaaacat ggcacaaaaa ggagtaagcc
    14761 ttatcaaggc agcatttgat acagataact ttctcatgcg ttttagtgag aaagtcttgg
    14821 acatcgtgac agccaatctt ctttttgtcg tctcttgttt gcccatcgtg acgattggag
    14881 tggctaaaat cagcctctac gagaccatgt tcgaagttaa gaagagcaga cgggtgcctg
    14941 tttttaaaat ctatctaaga tctttcaagc aaaatctgaa actaggtctt cagctgggtt
    15001 taatggagtt aggaattgtg tttcttaccc tttcagatct ctatcttttc tggggtcaaa
    15061 cagctctgcc cttccaattg ctgaaagcca tttgtttagg tattctgatt tttcttacta
    15121 tcgtgatgct ggctagttac cctatcgcgg cacgttatga cctatcttgg aaagaaattc
    15181 ttcaaaaagg attgatgttg gctagtttta actttccttg gttcttcctc atgttagcca
    15241 ttcttgtcct cattgtgatg gttctttatc tgtccgcctt cagtctactc ttaggtggct
    15301 cagtcttcct actttttggg tttggactat tggtctttat ccagactgga ttgatggaga
    15361 aaattttcgc aaaataccaa taggagcttt atttctgaaa ctactttcaa aggctccaaa
    15421 cgctattcta taagcgagaa actaaaatct aagtgtctat aagatattga aagccttttc
    15481 ggtaaagtgt atactaaaga agtaaagaaa aatctgcttt agcagaaaat aaaaataata
    15541 ggagaaaatc tatgtcagat ttgaaaaaat acgaaggtgt cattccagcc ttctacgcat
    15601 gttatgatga tcaaggagaa gtaagcccag aacgtacgcg tgccttggtt caatacttca
    15661 ttgataaagg tgttcaaggt ctttatgtca atggttcttc tggtgaatgt atctaccaaa
    15721 gcgttgaaga tcgcaagttg attttggaag aagtcatggc ggtagccaaa ggtaaattga
    15781 ccattattgc ccatgttgct tgcaataata ctaaagatag tatggaactt gctcgccatg
    15841 ctgaaagctt gggagtagat gctattgcaa cgattccacc aatttatttc cgcttgccag
    15901 aatactcagt tgccaaatac tggaacgata tcagttctgc agctccaaac acagactacg
    15961 tgatttacaa cattcctcaa ttggcagggg ttgctttgac tccaagcctt tacacagaaa
    16021 tgttgaaaaa tcctcgtgtt atcggtgtga agaactcttc tatgccagtt caagatatcc
    16081 aaacctttgt cagccttggt ggagaagacc atatcgtctt taatggtcct gatgagcagt
    16141 tcctaggagg acgcctcatg ggggctaggg ctggtatcgg tggtacttat ggtgctatgc
    16201 cagaactctt cttgaaactc aatcagttga ttgcggataa ggacctagaa acagcgcgtg
    16261 aattgcagta tgctatcaac gcaatcattg gtaaactcac ttctgctcat ggaaatatgt
    16321 acggtgtcat caaagaagtc ttgaaaatca atgaaggctt gaatattgga tctgttcgtt
    16381 caccattgac accagtgact gaagaagatc gtccagttgt agaagcggct gctgccttga
    16441 ttcgtgaaac caaggagcgc ttcctctaat ctaaaaggag gtatttatga catattacgt
    16501 tgcaattgat atcggtggaa ccaacatcaa gtatggtttg gttgatcaag aggggcaact
    16561 tcttgaatcg catgaaatgc caactgaggc gcataagggt ggacctcata tcttacaaaa
    16621 gaccaaagat atcgtagcta gttatttaga aaaaggccca gtagcaggtg ttgccatatc
    16681 ttctgctggg atggtggatc cggataaggg tgagattttc tatgctgggc cgcaaatccc
    16741 taactacgca ggcacccagt tcaaaaagga aatcgaagaa agctttacta ttccttgtga
    16801 gattgaaaat gatgtcaact gtgcaggtct tgctgaggca gtatctggtt caggcaaggg
    16861 agcaagtgtg acactttgct tgaccattgg aaccggtatc ggtggttgct tgattatgga
    16921 taggaaagtc ttccatggtt ttagcaattc agcctgtgaa gtcgggtata tgcatatgca
    16981 ggatggagct tttcaagact tggcttctac aacagcttta gtgaaatatg tagctgaagc
    17041 ccatggagaa gatgttgatc agtggaatgg ccgtagaatt ttcaaagaag ccactgaagg
    17101 aaacaaaatc tgcatggaag gtattgaccg tatggttgac tatctaggaa aaggtctggc
    17161 aaatatttgc tacgttgcca atccagaagt ggttattctt ggtggtggta tcatggggca
    17221 agaggctatc ctcaaaccta agatccgtac agccttgaaa gaggctttgg taccaagttt
    17281 agcagaaaaa acacgattag aatttgccca tcaccaaaat acagcaggga tgttgggtgc
    17341 atattatcat tttaagacaa aacaatccta gtttggctca gccaaactag gattttctta
    17401 cacgtttttg tctacgatag ccgttgagtt ttttattttc ccagtagcta ttaaagattt
    17461 tttccttgct ttcgcgattg atttccaaaa agtaggcata aatcaaatcg ataaagaaga
    17521 gcataggaag ttgagcggat attcgttgga tataggaggg ttggctgtgg gtggctacaa
    17581 gaacagtctc tgtataggtc tggctatctt tattgggaac acttgtaaag agtacagtct
    17641 ttgcccccat ctccttagca tctaatagac tatctaaaat agaaggagtt gagcctgaaa
    17701 gtgagaagcc cagtactaga caattttcat ccatgatgct ggttgtccag gcaaagccgt
    17761 cttggtctgt caaagcttcg cagaccacac ctagtcgcat aaaacgtaat ttcatttcac
    17821 gggcgacgag gccagaactc cctgttccaa agaagtagat acgctcagca tcttcgatta
    17881 gctgggcaat tcgttctagt tggatttcgt caatcaagtc ttgtgtttgt tccctcatat
    17941 tgctataact tctgaggact cgtttggtca gtggactgtg cttggagact tggttggctt
    18001 gattttctgc ctgatgttgg tattggaaaa taaattctcg gtagccagta aagccacact
    18061 ttttagcaaa gcgggtcaaa gcagcttgag aaatatgtaa tttttgggtg acttgttgag
    18121 aagataaatc atctgtaatc gtttcagctt gcaaaaaata gcgagcgatt tcttgttcta
    18181 ggtctgtcat ttcttcaaaa tgtgaatcaa tgatagttgc gatatctggt ttgtccatag
    18241 ggaaagctcc tttacatgag tcatactgga agactagatc agagaatagt cacacttcat
    18301 tataacacat aatataagga tagataaata aaaacgcatc tctgttttaa aaacgaaaaa
    18361 atcgaaaaag cttctctctt ttccataatt ttctactcaa attgtggtac aattaagagt
    18421 aagattttaa gttagaaatg agactgattt gtatgagaaa atttaacagc cattcgattc
    18481 cgattcggct taatttattg ttttcaatcg tcattttact ctttatgacc attattggtc
    18541 gtttgttgta tatgcaggtt ttgaacaagg atttttacga aaaaaagcta gcttcagcta
    18601 gtcagaccaa gattacaagc agttcagccc gtggggaaat ttatgatgct agtggaaaac
    18661 ctttggtaga aaatacgtta aagcaggttg tttcctttac gcgtagcaat aaaatgacgg
    18721 ctacagactt aaaagaaaca gctaaaaagt tactgactta tgtgagcatc agttctccaa
    18781 atttgacaga acgccagctg gcggattact atttggctga tcctgaaatc tataaaaaaa
    18841 tagtggaagc tctcccaagt gagaaacgct tggattcaga tggcaatcgt ctatccgaat
    18901 cagaactgta taacaatgcg gtcgatagtg tacaaacgag tcaactaaac tatacagagg
    18961 atgaaaagaa agaaatctat ctttttagtc agttaaatgc tgttggaaac tttgcgacag
    19021 gaaccattgc gacagatcct ctaaatgatt ctcaggtggc tgttattgcc tctatttcaa
    19081 aggagatgcc tggcattagt atttctactt cttgggatag aaaggttttg gaaacttccc
    19141 tttcttctat agttgggagt gtatccagtg aaaaagctgg tctcccagcg gaagaagcag
    19201 aagcctatct taaaaaaggc tattctctaa atgaccgtgt aggaacctcc tatttggaaa
    19261 agcaatatga agagacctta caaggaaaac gctcggtaaa agaaatccat ctggataaat
    19321 atggcaatat ggaaagcgtg gatacaattg aggaaggtag taagggaaac aatatcaaac
    19381 tgaccattga tttggccttc caagatagcg tggatgcttt actgaaaagt tatttcaatt
    19441 ctgagctaga aaatggtgga gccaagtatt ctgaaggtgt ctatgcagtc gcccttaacc
    19501 caaaaacagg tgcggttttg tctatgtcag ggattaaaca tgacttgaaa acgggagagt
    19561 tgacgcctga ttccttggga acggtaacca atgtctttgt tccaggttcg gttgtcaagg
    19621 cggcgaccat cagctcaggt tgggaaaatg gagtcttgtc aggaaaccag accttgacag
    19681 accagtccat tgtcttccaa ggttcagctc ccatcaattc ttggtatact caggcttacg
    19741 gttcattccc tatcacagcg gtccaagctc tggagtattc atcaaatacc tatatggtcc
    19801 aaacagcctt aggtcttatg gggcaaacct atcaacccaa tatgtttgtc ggcaccagca
    19861 atctagagtc tgctatggag aaactgcgtt caacctttgg cgaatatggc ttgggtactg
    19921 cgacaggaat tgacctacca gatgaatcta ctggatttgt tcccaaagag tatagctttg
    19981 ctaattacat tactaatgcc tttgggcagt ttgataacta tacgccgatg cagttggctc
    20041 agtatgtagc aactattgca aataatggtg ttcgtgtggc tcctcgtatt gttgaaggca
    20101 tttatggtaa taatgataag ggaggactgg gtgacttgat tcagcaactg caaccgacag
    20161 agatgaataa ggtcaatata tccgactccg atatgagcat cttgcaccaa ggtttttatc
    20221 aggttgccca tggtactagt ggattgacaa ctggacgtgc cttttcaaat ggtgccttgg
    20281 tatccattag cggaaaaaca ggtacagccg aaagctatgt ggcagatggt cagcaagcaa
    20341 ccaataccaa tgcggtggcc tatgccccat ctgataatcc ccaaatcgct gtcgcagtgg
    20401 tctttcctca taataccaat ctaacaaatg gtgtaggacc ttccattgcg cgtgacatta
    20461 tcaatctgta tcaaaaatac catccaatga actagaaagg aaattatgct ttatccaaca
    20521 cctattgcca agttgattga cagttattct aagttaccag gtatcgggat taagacggct
    20581 acgcgtctgg ccttttatac gattgggatg tctgctgatg atgtcaatga atttgcaaaa
    20641 aatctccttt ctgctaagag agaattgaca tattgttcta tttgtggacg tttgacagac
    20701 gacgatcctt gttctatctg tactgatccg actcgtgacc agacaacaat tttagttctt
    20761 gaggatagta gagatgtggc agccatggaa aatatccaag aataccatgg actctatcat
    20821 gtccttcatg gcctcatttc tcctatgaat ggtatcagtc cggacgatat caatctcaag
    20881 agccttatga ctcgtcttat ggatagtgag gtttcagaag tgattgtggc gactaatgct
    20941 acagcggatg gtgaagcgac ttccatgtat ctttcacgtt tgctcaagcc ggctggtatc
    21001 aaggttacgc gtctagcacg aggtctcgct gtgggagcgg acattgagta tgcggacgaa
    21061 gtgacactct tacgagccat tgaaaatcgg acagagttgt aagtgtaggc aaatttacga
    21121 actccattca tttataaaaa atcaaagagg ctgaaaatcg ttcctatcgg cctctttttg
    21181 tatagtgtga tgagtaggct caggttcaag ttttaaaaaa ccaagcaaat atgatatact
    21241 aaagagcgag tattctagta gaattaggac aaataatatg aaacaaacga ttattctttt
    21301 atatggtgga cggagtgcgg aacgcgaagt ctctgtcctt tcagctgaga gtgtcatgcg
    21361 tgcggtcgat tacgaccgtt tcacagtcaa gactttcttt atcagtcagt caggtgactt
    21421 tatcaaaaca caggaattta gtcatgctcc ggggcaagaa gaccgtctca tgaccaatga
    21481 aaccattgat tgggataaga aagttgcacc aagtgctatc tacgaagaag gtgcagtggt
    21541 ctttccagtc cttcacgggc caatgggaga agatggctct gttcaaggat tcttggaagt
    21601 tttgaaaatg ccttacgttg gttgcaacat tttgtcatca agtcttgcca tggataaaat
    21661 cacgactaag cgtgttctgg aatctgctgg tattgcccaa gttccttatg tggctatcgt
    21721 tgaaggcgat gatgtgactg ctaaaatcgc tgaagtggaa gaaaaattgg cttatccagt
    21781 cttcactaag ccgtcaaaca tggggtctag tgtcggtatt tctaagtctg aaaaccaaga
    21841 agaactccgt caagccttaa aacttgcctt ccgatatgac agccgtgtct tggttgagca
    21901 aggagtgaat gcccgtgaaa ttgaggttgg cctcttgggt aactacgatg tcaagagcac
    21961 gctacctgga gaagttgtca aggacgttgc cttttatgac tacgatgcca agtatattga
    22021 taacaagatt actatggata ttcctgccaa aatcagtgat gatgtggtgg ctgtcatgcg
    22081 tcaaaatgca gaaacagcct tccgtgccat tggtggcctt ggtctatctc gttgcgattt
    22141 cttctataca gataagggag agatttttct caacgagctc aataccatgc caggttttac
    22201 ccagtggtct atgtacccac tactttggga caatatgggg atcagctacc cagaactaat
    22261 cgaacgtttg gttgaccttg ccaaggaaag ctttgacaag cgcgaagcgc atttgatata
    22321 aaatgaaaga gagggtagaa gccagaacca tcactgcacg gtgactagag ttctcggact
    22381 tcagcccttt ttaaaggagt agaaatgaaa ttaacaatcc atgaaattgc ccaagttgtt
    22441 ggagccaaaa atgatatcag tatctttgag gacacccagt tagaaaaagc tgagtttgat
    22501 agtcgtttga ttggaactgg agatttattt gtgccactta aaggtgcgcg tgatggccat
    22561 gactttattg aaacagcctt tgaaaatggt gcagcagtaa ccttgtctga gaaagaggtc
    22621 tcaaatcatc cttacatttt agtagatgat gttttgacag cctttcaatc cctagcatcc
    22681 tactatcttg aaaaaacgac tgttgatgtc tttgctgtta caggttcaaa tggcaagaca
    22741 acgactaagg atatgttggc gcatttactg tcaacaagat acaagaccta caaaacacaa
    22801 ggcaattaca ataatgagat tggccttcct tacacagttc tccacatgcc tgaaggaaca
    22861 gaaaagttgg tcttggagat ggggcaggac cacttgggag atattcatct cttgtctgaa
    22921 ttggctcgtc caaaaacagt catcgtgacc ttggttggag aagctcattt ggcctttttc
    22981 aaagatcgtt ctgagattgc taaaggaaaa atgcaaattg cagacggaat ggcttcaggt
    23041 tccttgtttt tagcgccggc tgaccctatc gtagaggact atttgccaac tgataaaaag
    23101 gtggttcgtt ttggtcaagg agcagagctg gaaattactg acttggttga gcgcaaagat
    23161 agtctgacct tcaaggccaa tttcttagag caagtccttg atttgccagt aactggcaag
    23221 tacaatgcga caaatgctat gattgcatcc tatgttgcct tgcaagaagg agtttcagag
    23281 gagcaaattc gtttggcctt ccaacatctt gaattgacgc gtaaccgtac cgagtggaag
    23341 aaagcagtca atggagcaga tatcctgtca gatgtttaca atgccaatcc aactgctatg
    23401 aaactgattt tagagacttt ctctgccatt ccagccaatg aaggtggcaa gaaaattgca
    23461 gttttggcgg atatgaagga gcttggtgac cagtctgttc aacttcataa tcagatgatt
    23521 ttgagcctct ccccagatgt gcttgatatc gttattttct atggagaaga tattgctcag
    23581 ttggctcaat tggccagtca aatgtttcca atcggccacg tttactactt caagaaaaca
    23641 gaagaccagg atcaatttga agacctagtc aagcaggtta aggaaagcct tggagcctat
    23701 gaccaaatct tgctaaaagg ttctaactct atgaatctag ccaaattggt agaaagttta
    23761 gaaaatgaag ccaagtgatt ttgttaagta tctgcaaaga atgattgccc ttacagatac
    23821 tggcttaacc tttacaaaag atccttttga ccgtgagcgc tacgaggact tgcgaagtct
    23881 gttatctgaa atgttgaatc agggatcaga cctggatgta gaagaagtag cagaagtctt
    23941 gaaaccaact tcagcttatg cgactccctt aatggacgtc cgtgcttgga ttgttgagga
    24001 tgagaagatt tgtctggtta ggggacaagg agaggatagt tgggctttgc caggtggctt
    24061 tggtgaagtc ggctattctc caactgaaaa tattctcaag gaaattgaag aagaaaccgg
    24121 ttttaaagcc aaagttgaaa gactgctagc tgtttttgat accaatcgtt tccaactaca
    24181 gagcaaacaa tatgcaaagt ttgtttttga atgtaagctt ctcgatggac aattccaaga
    24241 aaatcaagaa atcgctgacc ttcaattttt tgcaattgac caactgccga atttatctga
    24301 aaaacgcatt accaaggagc aaatcgagat tctttggcag gtttatcaag gtcagaggga
    24361 gcaatatctt gactaagaag atgattatcg tatttctaaa tccatttttg acaactagca
    24421 tggtataata atatgcagga aaattttgaa ttatgaggaa gactagatga atttatggga
    24481 tattttcttt acgactcagg caaccgagcc gcccaaattt gacctttttt ggtatgttag
    24541 cctatttacg ctcttagcct taacctttta tacagcccat cgctatcgtg aaaagaaggt
    24601 ttaccaacga tttttccaaa tcttgcagac tgttcagtta atccttcttt atggttggta
    24661 ctgggttaat catatgccac tgtcagaaag cctacccttt taccattgcc gtatggctat
    24721 gtttgtggta ctcttgcttc ctggtcagtc caaatataaa caatactttg cattattggg
    24781 aacatttggg acattagcag cctttgttta tccagtgcca gatgcttacc cttttccaca
    24841 tgtcaccatt ctatccttta tctttggtca tttagcactc ttggggaact ctctagttta
    24901 tctattgaga cagtataatg cgcgattgct ggatgtgaag ggaatttttc tcatgacctt
    24961 tgccctaaat gccttgattt ttgtggtcaa tttggtgaca ggtggcgatt acggattttt
    25021 gacaaaaccg ccattggttg gggatcacgg tctagtagct aattatttac ttgtttcaat
    25081 tgtgctggta gctactatca gtttgactaa gaaaatctta gaattctttt tagctcaaga
    25141 agcagaaaaa atgattgcaa aggaagctta acacagagtt ttcttttttg ctcttagaga
    25201 gtttttacaa gcagcttata aaataagaat ttctgaatag acaaactcaa aaaatggctg
    25261 ggaaatttag gaaaaaagca agcacgatta aattttttgt gttataatat tttgtgaata
    25321 gctatgccta tgtttagcta tggaataata cgaagtgcga aacttggaag atagagagga
    25381 agcgatgtaa tggctagaga aggctttttt acaggtctag atattggaac aagctctgtc
    25441 aaggtgcttg tggccgagca gagaaatggt gaattaaatg taattggcgt gagtaatgcc
    25501 aaaagtaaag gtgtaaagga tggaattatt gttgatattg atgcagcagc aactgctatc
    25561 aagtcagcca tttcccaagc ggaagaaaag gcaggcattt cgattaaatc agtgaatgtc
    25621 ggcttgcctg gtaatctttt gcaggtagaa ccaactcagg ggatgattcc agtaacatct
    25681 gatactaagg aaattacgga tcaagatgtt gaaaatgttg tcaaatcagc tttgacaaag
    25741 agtatgacac ctgaccgtga agtcattacc tttattcctg aagaatttat tgtggatggt
    25801 ttccaaggga ttcgtgaccc acgtggtatg atgggggttc gccttgaaat gcgtggtttg
    25861 ctttatacag gacctcgtac tatcttgcac aatttgcgta agacggttga gcgtgcaggt
    25921 gttcaggttg aaaatgttat catttcacca ctagcaatgg ttcagtctgt tttgaacgaa
    25981 ggggaacgtg aatttggtgc tacagtgatt gatatggggg caggtcaaac gactgtcgct
    26041 acaatccgta atcaagaact ccagttcaca catattctcc aagaaggtgg agattatgta
    26101 actaaagata tctccaaggt tttgaaaacc tctcgcaaat tagcggaagg cttgaaactg
    26161 aattacgggg aagcctatcc gcctcttgca agcaaagaaa ccttccaagt agaggttatt
    26221 ggagaagtgg aagcagtcga agtgacggaa gcctacttgt cagaaattat ttctgcacga
    26281 atcaagcaca tccttgaaca aatcaagcaa gaattagata gaaggcgtct attggacctc
    26341 cctggtggta ttgtcttaat cggtgggaat gccattttac caggtatggt tgagcttgct
    26401 caggaagtct ttggcgtccg tgtcaagctt tatgttccaa atcaagttgg tatccgtaat
    26461 ccagcctttg cgcatgtgat tagtttatca gaatttgcgg gtcaattaac agaagttaat
    26521 cttttggctc agggagcgat aaaaggtgag aatgacttaa gtcatcagcc aattagtttt
    26581 ggtgggatgc tgcaaaaaac agctcagttt gtacaatcaa cgcctgttca accagcacct
    26641 gctccagaag tagagccggt ggcgcctaca gaaccaatgg cggatttcca acaagcttca
    26701 caaaataaac cgaaattagc agatcgtttc cgtggcttga tcggaagcat gtttgacgaa
    26761 taaagaggaa aaataaatta tgacattttc atttgataca gctgctgctc aaggggcagt
    26821 gattaaagta attggtgtcg gtggaggtgg tggcaatgcc atcaaccgta tggtcgacga
    26881 aggtgttaca ggcgtagaat ttatcgcagc aaacacagat gtacaagcat tgagtagtac
    26941 aaaagctgag actgttattc agttgggacc taaattgact cgtggtttgg gtgcaggagg
    27001 tcaacctgag gttggtcgta aagccgctga agaaagcgaa gaaacactga cggaagctat
    27061 tagtggtgcc gatatggtct tcatcactgc tggtatggga ggaggctctg gaactggagc
    27121 tgctcctgtt attgctcgta tcgccaaaga tttaggtgcg cttacagttg gtgttgtaac
    27181 acgtcccttt ggttttgaag gaagtaagcg tggacaattt gctgtagaag gaatcaatca
    27241 acttcgtgag catgtagaca ctctattgat tatctcaaac aacaatttgc ttgaaattgt
    27301 tgataagaaa acaccgcttt tggaggctct tagcgaagcg gataacgttc ttcgtcaagg
    27361 tgttcaaggg attaccgatt tgattaccaa tccaggattg attaaccttg actttgccga
    27421 tgtgaaaacg gtaatggcaa acaaagggaa tgctcttatg ggtattggta tcggtagtgg
    27481 agaagaacgt gtggtagaag cggcacgtaa ggcaatctat tcaccacttc ttgaaacaac
    27541 tattgacggt gctgaggatg ttatcgtcaa cgttactggt ggtcttgact taaccttgat
    27601 tgaggcagaa gaggcttcac aaattgtgaa ccaggcagca ggtcaaggag tgaacatctg
    27661 gctcggtact tcaattgatg aaagtatgcg tgatgaaatt cgtgtaacag ttgttgcaac
    27721 gggtgttcgt caagaccgcg tagaaaaggt tgtggctcca caagctagat ctgctactaa
    27781 ctaccgtgag acagtgaaac cagctcattc acatggcttt gatcgtcatt ttgatatggc
    27841 agaaacagtt gaattgccaa aacaaaatcc acgtcgtttg gaaccaactc aggcatctgc
    27901 ttttggtgat tgggatcttc gccgtgaatc gattgttcgt acaacagatt cagtcgtttc
    27961 tccagtcgag cgctttgaag ccccaatttc acaagatgaa gatgaattgg atacacctcc
    28021 atttttcaaa aatcgttaag taaatgaatg taaaagaaaa tacagaactt gtttttcgag
    28081 aagttgcaga ggctagtctg agtgctcatc gagagagtgg ttcggtctct gtcattgcag
    28141 ttaccaagta tgtagatgta ccgacagcgg aagccttgct tccgctaggt gtccatcata
    28201 tcggtgaaaa tcgtgtagat aagtttctgg aaaaatatga agctttaaaa gatcgagatg
    28261 tgacttggca tttgattggt accttgcaaa gacgtaaggt gaaagatgtc attcaatacg
    28321 ttgattattt ccatgcattg gactcagtaa agctagcagg ggaaattcaa aaaagaagtg
    28381 accgagtcat caagtgtttc cttcaagtaa atatttctaa agaagaaagc aaacacggtt
    28441 tttcgagaga ggaactgctg gaaatcttgc cagagttagc cagactagat aagattgaat
    28501 atgttggttt aatgacgatg gcaccttttg aggctagcag tgagcagttg aaagagattt
    28561 tcaaggcggc ccaagattta caaagagaaa ttcaagagaa acaaattcca aatatgccta
    28621 tgaccgagtt aagtatggga atgagtcgtg attataaaga agcgattcaa ttcggttcca
    28681 cttttgttcg tataggtaca tcatttttta agtaggagag aaccatgtct ttaaaagata
    28741 gattcgatag atttatagat tattttacgg aggatgagga ttcaagtctc ccttatgaaa
    28801 aaagagatga gcctgtgttt acttcagtaa attcttcaca ggaaccggct ctcccaatga
    28861 atcaaccttc acagtcggct gggacaaaag agaacaatat caccagactt catgcaagac
    28921 aacaggaatt ggcaaatcag agtcagcgtg caacggataa ggtcattata gatgttcgtt
    28981 atcctagaaa atatgaggat gcaacagaaa ttgttgattt attggcagga aacgaaagta
    29041 tcttgattga ttttcagtat atgacagagg tgcaggctcg tcgttgtttg gactatttgg
    29101 atggagcttg tcatgtttta gctggaaatt tgaaaaaggt agcttctacc atgtatttgt
    29161 tgacaccagt gaacgttatt gtaaatgttg aagatatccg tttaccagat gaagatcaac
    29221 agggtgagtt cggttttgat atgaagcgaa atagagtacg ataatgattt ttttaattcg
    29281 tatgatttat aatgcagtgg atatttactc cctaattttg gtagccttcg ctgtcatgtc
    29341 ttggtttcca ggtgcctacg aatccagttt aggtcgttgg attgtagcgt tggtaaaacc
    29401 agtgcttgct cccttgcaac gcctgccttt acagatagcg ggtcttgatt tatctgtttg
    29461 ggtcgcgatt gttttggttc gatttttagg agaaaaccta gtgcgttttc tggcgatgat
    29521 aggatgaata aagggattta tcagcatttc tccatagaag atcgtccatt tcttgacaag
    29581 ggaatggaat ggataaagaa ggtagaagat agctatgctc cttttttaac tccttttatc
    29641 aatcctcatc aggagaagct attaaagatt ttggccaaaa cctatggtct tgcttgtagc
    29701 agtagtgggg aattcgtctc gagtgagtat gttcgagttt tattataccc agattatttc
    29761 caaccagagt tttcagattt tgaaatatct ctccaggaaa ttgtgtattc caataaattt
    29821 gaacatttaa cgcatgctaa gattttaggg acagtcatca atcaattagg gattgaacgg
    29881 aaactttttg gagatatcct agtagatgaa gaacgggcgc agattatgat taatcagcag
    29941 tttcttcttc tctttcaaga tggactaaag aaaattggtc gtatacctgt ttcgctggag
    30001 gaacgtcctt tcaccgagaa aatagataag ctagaacagt atcgagaact ggatttatct
    30061 gtgtctagtt ttcgattaga tgttctttta tcaaatgttt tgaaactatc taggaatcaa
    30121 gcaaaccagt tgattgaaaa gaaacttgtc caagtaaatt atcatgtggt agacaaatca
    30181 gattacactg ttcaagttgg agacttgatt agtgtgagaa aatttggtcg cttgagatta
    30241 cttcaagata agggacaaac gaaaaaagag aagaaaaaaa taaccgtcca gttattatta
    30301 agtaagtgag gaatagaatg ccaattacat cattagaaat aaaggacaag acttttggaa
    30361 ctcgattcag aggttttgat ccagaagaag tcgatgaatt tttagatatt gtggttcgtg
    30421 attacgaaga tcttgtgcgt gcgaatcatg ataaaaattt gcgtattaag agtttagaag
    30481 agcgtttgtc ttactttgat gaaataaaag attcattgag ccagtctgta ttgattgctc
    30541 aggatacagc tgagagagtg aaacaggcgg cgcatgaacg ttcaaacaat atcattcatc
    30601 aagcagagca agatgcgcaa cgcttgttgg aagaagctaa atataaggca aacgagattc
    30661 ttcgtcaagc aactgataat gctaagaaag tcgctgttga aacagaagaa ttgaagaaca
    30721 agagccgtgt cttccaccaa cgtctcaaat ctacaattga gagtcagttg gctattgttg
    30781 aatcttcaga ttgggaagat attctccgtc caacagctac ttatcttcaa accagtgatg
    30841 aagcctttaa agaagtggtt agcgaagtac ttggagaacc gattccagct ccaattgaag
    30901 aagaaccaat tgatatgaca cgtcagttct ctcaagcaga aatggaagaa ttacaagctc
    30961 gtattgaggt agccgataaa gaattgtctg aatttgaagc tcagattaaa caggaagtgg
    31021 aaactccaac tcctgtagtg agtcctcaag ttgaagaaga gcctctgctc atccagttgg
    31081 cccaatgtat gaagaaccag aagtagctcc agtgcatccg acaggtccaa caccagctac
    31141 agaaactgtt gattcagcac caggatttga agcaccgcaa gaatccgtta caattttata
    31201 agaaacgatg tgagaacaat atcttatcct tatatttcca gcgagcagga gatggtgtga
    31261 gtcctgcatt ccctaacgat aagattatcc tctcaaaaac tcaagtctga atctagtaag
    31321 atttgacgtt tcccacgtta cgggataaga gggagaaaga ctaaatcttt ttccgaataa
    31381 aggtggtacc acgattttcg tcctttttgg aagtcgtggt ttttaatttg ttattattta
    31441 taaaggagat accatgaaac taaaagatac ccttaatctt gggaaaacag ctttcccaat
    31501 gcgtgcaggc cttccgacca aagagccagt ttggcaaaag gaatgggaag atgcaaaact
    31561 ttaccaacgt cgtcaagaac taaatgaagg gaaaccgcat tttgtcttgc atgatggccc
    31621 tccatacgca aacggaaata tccacgttgg acatgccatg aatcatatct caaaagatat
    31681 catcattcgt tctaagtcta tgtcaggttt taacgcacct tatatcccag gttgggatac
    31741 tcatggtctg ccaatcgagc aagttttggc aaagcaaggt gtgaagcgca aagaaatgga
    31801 cttggttgag tacttgaaac tctgtcgtga gtacgctctt tctcaagttt ataaacaacg
    31861 tgatgatttc aaacgcttgg ggatgtcagg tgactgggaa aatttatatg tgactttaac
    31921 tccagactat gaagcagccc aaatccgtgt ctttggtgag atggctaata agggttatat
    31981 ctaccgtggt gctaagccag tttactggtc atggtcatct gagtcagccc ttgccgaagc
    32041 ggaaattgaa taccatgatt tggtttcgac ttcactttat tatgccaata aggtaaaaga
    32101 tggcaaaggt atcctagata cagatactta tatcgtagtc tggacaacaa ctccatttac
    32161 catcacagct tctcgtggtt tgactgttgg tgcagatatt gattacgttt tggttcaacc
    32221 tgctggtgaa actcgtaagt ttgtcgttgc tgcagaattg ttgactagct tgtctgagaa
    32281 atttggctgg gctgatgttc aagtgttggc aacttaccgt ggtcaagaac tcaaccacat
    32341 cgtaacagaa cacccatggg atacagctgt agatgagttg gtaatccttg gtgatcacgt
    32401 taccactgac tctggtacag gtatcgtcca tacagcccct ggttttggtg aggacgacta
    32461 caatgttggt attgctaatg gtcttgaagt cgcagtgact gttgacgaac gcggtatcat
    32521 gatggcgaat gctggtcctg agtttgaagg tcagttctac gacaaggttg taccaactgt
    32581 tattgaaaaa cttggtaacc tccttctagc ccaagaagaa atctctcact catacccatt
    32641 tgactggcgt actaagaaac caatcatctg gcgtgcagtt ccacaatggt ttgcctcagt
    32701 ttcaaaattc cgccaagaaa tcttggatgc tattgataaa gttaaattcc atacagaatg
    32761 gggtaaagta cgtctatata atatgattcg tgaccgtggt gactgggtta tctctcgtca
    32821 acgtgcttgg ggtgttccac ttccaatctt ctatgcagaa gacggtacag ctatcatgac
    32881 agctgagact attgaacatg tggcgcaact ctttgaagta catggttcaa gcatttggtg
    32941 ggaacgtgat gccaaggacc tcttgccaga aggatttaca catccaggtt ctccaaatgg
    33001 ggagttcaag aaagaaacag atattatgga tgtatggttt gactcaggtt catcatggaa
    33061 tggtgttttg gtaaatcgtc caaatctgac ttatccagct gacctttacc ttgaaggttc
    33121 tgaccaatac cgtggttggt tcaactcatc actcattaca tctgttgcca accatggcgt
    33181 agcaccttac aaacaaatct tgtcacaagg ttttaccctt gatggtaaag gtgagaagat
    33241 gtctaaatca cttggcaata ccattgctcc aagtgatgtt gaaaaacaat ttggtgcaga
    33301 aatcttgcgt ctctgggtaa caagtgttga ctcaagcaat gacgtgcgta tctctatgga
    33361 tattttgagc caagtttctg aaacttaccg taagattcgt aacactcttc gtttcttgat
    33421 tgccaataca tctgacttta acccagctca agatgtagtc gcttacgatg agcttcgttc
    33481 agttgataag tacatgacga ttcgctttaa ccagcttgtc aagaccattc gtgatgccta
    33541 tgcagacttt gaattcttga cgatctacaa ggccttggtg aactttatca acgttgactt
    33601 gtcagccttc taccttgatt ttgccaaaga tgttgtttac attgaaggtg ccaaatcact
    33661 ggaacgccgt caaatgcaga ctgtcttcta tgacattctt gtcaaaatca ccaaactctt
    33721 gacaccaatc cttcctcaca ctgcggaaga aatttggtca tatcttgagt ttgaaacaga
    33781 agacttcgtc caattgtcag aattaccaga ggctcaaact tttgctaatc aagaagaaat
    33841 cttggataca tgggcagcct tcatggactt ccgtggacaa gctcaaaaag ccttggaaga
    33901 agctcgtaat gcaaaagtaa tcggtaaatc acttgaagca cacttgacag tttatccaaa
    33961 cgaagttgtg aaaactctac tcgaagcagt aaacagcaat gtggctcaac ttttgatcgt
    34021 gtcagacttg accatcgcag aaggaccagc tccagaagct gcccttagct tcgaagatgt
    34081 agccttcaca gttgaacgcg ctgcaggtga agtatgtgac cgttgccgtc gtattgaccc
    34141 aacaacagca gaacgtagct accaggcagt tatctgtgac cactgtgcaa gtatcgtaga
    34201 agaaaacttt gcagatgcag tcgcagaagg atttgaagag aaataagatt gaaaagtcta
    34261 ggcaaaattc aatttgagaa gaaaagacaa ctaattttat agtctattaa acgcattgta
    34321 tcacgttttt gaacacctga tatgatgcgt tttttatttt taaaatttgc aaggtgtgac
    34381 tttttatact catactcaat gaaaatcaaa aagcaaacta ggaagctagc cgcaggctgc
    34441 tcaaaacact gttttgaggt tgtagataag actgacgaag tcagtaacat atatatggta
    34501 aggcgacgct gacgtggttt gaagagattt tcgaagagta tcaacaagaa tcaaagagaa
    34561 acttagcaag ctaacagtag taagataaaa taggaatttg atattaggga taagattggt
    34621 aaatagtgta
//
LOCUS       DAVLHC010000018        33418 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.018, whole genome shotgun sequence.
ACCESSION   DAVLHC010000018 DAVLHC010000000
VERSION     DAVLHC010000018.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 33418)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 33418)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..33418
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.018"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(<1..3645)
                     /locus_tag="VXE25_000991"
     CDS             complement(<1..3645)
                     /locus_tag="VXE25_000991"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000639856.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HEV0771471.1"
                     /translation="MIYLTEGNTPLNEAYNDEIVHLGNNTYQLTFRFPTSDTKWELLK
                     EETFLTADDLHGEQDFYIFEVEKQQGYIQVYANQVISLLNNYIVSSIEVDRVSGTRVL
                     SAFAGSITRANPFSFFSDIDDRHTLNIKDKNAMEVLAKGKHSILGQWGGDMVRNGYNL
                     RLLKNGGSENESLFMYKKNLSSYQHKTSTKSLKTRITFKTTVKGEGENAVDHDYMVVI
                     DSPLLGNYSQIYEDVVEVNDQDVTDEASLIEYGKQYFRTSMCDMLEDNLEISVVGQSD
                     VAVQMFDVVSFYHEWYGLDVRKKITKYTYSPMAKLLKSIGFGTFQSSLANAIGGIVND
                     AVLNESRNLHQIFEERLKKEIANADRAFDAEFFKREKTITDAIELAKAKAEEVKQELS
                     DTINQRFNSFDNGPLKEAKRKAEEALRNAGASSSLAQESKRIGLDSVARLEAFKSQTT
                     SAQTALSGDLDALKRTIVNDIRPKQAQVEAEIAKQVEALVQTKKELAGASTLLAQEAK
                     RIELDSVARLEAFKSQTTSAQTALSGDLDALKRTIANDIRPKQAQAETEIAKQVEALS
                     RTKNELAGVKSAQATYEETTTRRLSELTNLANGKASKSELTQTAEELASRIASVQASG
                     RNLFLNSLFKQDIPKTGIWTTSTYTATIDSESKYLGHKALKIIGLNPSGRDGGNPKVT
                     YPALGQFGKVIPGSTTNQDVTISFYAKANKNGIMLRSRLGNIGYKTGNVTLSTEIKRY
                     VVHIPKGWTNESKQTTNEWLFNFNQEGTVWIWMPKFEISDVDTSYSEAPEDVESQIST
                     VESTFKQRADSLDAGVNRLTEGLRTKVDISALNVTAENIRQSVKSLETDTQNKLNQKL
                     SQAEFEVRAGSIRQEILNATKDKASKSELTQTAEELASKIASVQVGGRNYIRGTKRMM
                     LARGLWASGTFRPSGAGTAKTIDVSDSPATGFDKAIRLTSSNARDQIGIAQDGFHISQ
                     GTYTMSCWVKGRRGQKVKLQTYWQVNDNSGISPIFTLKDENWTKLSFTSARNRAGVAS
                     IGYVYLVNAEVGEYLDVLAPQLEDGSLATSSKEAPEDIEGQISTVESTFKQRANSLDA
                     GVRSLTEGLRTKVDISSLNVTAENIRQSVKRLETDTQNKLNQKLSQAEFEVRAGSIRQ
                     EILNATKDKASKSELTQTAEELASRIASVQASGRNLFLNSLFKQDISKTGIWTTSTYT
                     ATIDSESKYLG"
     gene            complement(3642..4340)
                     /locus_tag="VXE25_000992"
     CDS             complement(3642..4340)
                     /locus_tag="VXE25_000992"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000499602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HEV0771472.1"
                     /translation="MFYMIINGFNTSTIPHCVVTDFGQVEAAKPRVAEDANLYGANGS
                     YRVLDGGYESYERTFSFYIPKLLDVSTIVEKFQPKDNVLEFSYQLGSVFYADFIGATY
                     SPHGMHAWKLEIKLNMQPFRYQKNVAPLIFTASGNINNPGSVYSEPVIEIEGDGDISL
                     TIGRTTMHLTVRRKVTIDCRHKKQNIYNADGAVQNTLRKRGGFFELAVGNNSLVFTGS
                     VRKVTVRPNWRYIL"
     gene            complement(4340..6805)
                     /locus_tag="VXE25_000993"
     CDS             complement(4340..6805)
                     /locus_tag="VXE25_000993"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000179967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PblA"
                     /protein_id="HEV0771473.1"
                     /translation="MATELGKAYVQIIPSAKGISGMIQKEMGGEVASAGVSAGESLGS
                     KMMGAVSGVIAAAGIGKAIGASINEGAALQQSLGGVETLFKDSADKVKGFANEAYKTT
                     GLSANAYMENVTGFSASLLQSLGGDTDKAAETANMAMIDMSDNANKMGTSMESIQLAY
                     QGFAKQNYTMLDNLKLGYGGTKQEMQRLLADAEKLTGVKYDINNLSDVYSAIHTIQEN
                     LDITGTTAREAATTFTGSFESMKSAAQNVLGKLSLGEDIQPALQALMETTSTFLFGNL
                     IPMIGNILKQIPILILGGIKGVFSGIFGEGLGSIMGSIVTALGSAFLAFKAFSTVSGL
                     LSGIPAVLTTIKTAVTGLFTVMSANPIGIAIAAIAGLTAGLVYFFTQTETGRQIWSSF
                     VAWIKQAWQGIADFFVNLWSGISEGASTLWDGVVTAWNAVVTFFSDLWVRIQEAASVA
                     WTAITTAVMAIVQPFIDGFMNIWNNISDGLTQIWEGIKMIFQGVWEFIKSIFLGAILI
                     IINLVTGNFNQLGADLSLIWKGIKNSISMIWEGIKTYFSGVVDVIVGYGIAIFENFST
                     TLSTIWKGLSAAGKAIFDSFAQILSNIWNTIKFVASSAWEGLKSTVLGLIDGLVQGAK
                     NAWESMKQGVRDLVSNVTSIFDGIRNIDLWSAGKAILDGFLGGLKSAWGAVTDFVGGI
                     ASWIRDHKGPIEYDRKLLIPAGNAIMQGLDRGLQDRFKDVKKSVSGMAGEISNAFSND
                     DFGLSGTPTIAKNIEASLAMPSAQIEAKDSQTVSEIAILRASMEKILTAILEKPSDTY
                     LDADKISMSVYQRQGAIYAREGM"
     gene            complement(6805..7191)
                     /locus_tag="VXE25_000994"
     CDS             complement(6805..7191)
                     /locus_tag="VXE25_000994"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000560880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5361 domain-containing protein"
                     /protein_id="HEV0771474.1"
                     /translation="MIALDEDALICDLAETYQIYDYKQLPLNQVAVFAYGLRDDSRIK
                     QMMSDQIVPLETTLLASIVDRLSLSLWLKTKDGQKGVNRPASIAELLTKNNKEEGDER
                     DYLVFESGEDFENYRKALLAKTGGED"
     gene            complement(7203..7478)
                     /locus_tag="VXE25_000995"
     CDS             complement(7203..7478)
                     /locus_tag="VXE25_000995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000391234.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771475.1"
                     /translation="MEEILKGKTESGFEYKIPKKRLRNFYLMREASKMEKGDFEAAEK
                     LLNLLFGKKQAEEFLSHLDDGDDFIDTEVLFADIKSIFESNKDLKKS"
     gene            complement(7484..8041)
                     /locus_tag="VXE25_000996"
     CDS             complement(7484..8041)
                     /locus_tag="VXE25_000996"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010050515.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HEV0771476.1"
                     /translation="MTTASASNVTAAKPKIGGAVSTAPAGTTLPTNAKTDLDAAFETL
                     GYISDDGLTNANSPESKAIKAWGGQTVLSSQTEKKDTFKYKLIEGLNIKVLKEVYGPD
                     NVSGTLETGITVKANGKELPEHCLVIDTLLKNGYVKRVVIPRGKVSEIGEISYKDGEP
                     IGYELTITALPDNSENTHYEYIQGA"
     gene            complement(8108..8443)
                     /locus_tag="VXE25_000997"
     CDS             complement(8108..8443)
                     /locus_tag="VXE25_000997"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000573598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771477.1"
                     /translation="MIELVIKKFLDGQLDVPSFFEHKPNMPESYVILEKTGSGGSDYV
                     HSATFAFQSYAPSLQKAAELNEKVKKVVEDLITVNEVSGVHHNSDYNFTDTETKQYRY
                     QAVYDINYF"
     gene            complement(8440..8676)
                     /locus_tag="VXE25_000998"
     CDS             complement(8440..8676)
                     /locus_tag="VXE25_000998"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000069060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771478.1"
                     /translation="MSDMKFQLNSAGVSALLRSSEMQGILREKGQGIAERAGEGFELT
                     VSPGQKRANAKISTTDIKSMARNKKHNILLKAMR"
     gene            complement(8669..9007)
                     /locus_tag="VXE25_000999"
     CDS             complement(8669..9007)
                     /locus_tag="VXE25_000999"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000532631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771479.1"
                     /translation="MTYLKGIPVILIDKVETGNDDFGHPIHRDVEIEVQNVLVVPTSS
                     EDVINQMNLTGKKAEYTLGIPKGDTNKWENREVKFFGRKWRTIGIPQEGIESMIPLSW
                     NRKVMVEVYE"
     gene            complement(8952..9392)
                     /locus_tag="VXE25_001000"
     CDS             complement(8952..9392)
                     /locus_tag="VXE25_001000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000536419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage Gp19/Gp15/Gp42 family protein"
                     /protein_id="HEV0771480.1"
                     /translation="MGTFAKIEDLELLWRSLKFDERARAEALLEVVSNSLRVEAEKVG
                     KDLDDMVAESVSFASVAKSVTVDIVARTLMTSTDHEPMTQVSESALGYSFSGSYLVPG
                     GGLFIKDTELKRLGLKKKQRYGAIEIYDLPKRNPCHFNRQGGNW"
     gene            complement(9396..9608)
                     /locus_tag="VXE25_001001"
     CDS             complement(9396..9608)
                     /locus_tag="VXE25_001001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001240370.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771481.1"
                     /translation="MALYRDTKTGVIISAESVLGGDWVPVEDTAPSGADLTVAELKSS
                     LDELGVDYDKGSKKSDLVALYEENKS"
     gene            complement(9614..10510)
                     /locus_tag="VXE25_001002"
     CDS             complement(9614..10510)
                     /locus_tag="VXE25_001002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000774647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage major capsid protein"
                     /protein_id="HEV0771482.1"
                     /translation="MADNATKAGTLFKPELVKELISKVQGRSVLAKLSSQTPIPFNGV
                     EQFIFNLEGNAQIVGEGEQKQAGKAKITSKVIKPLKFVYQARITDEFKYASEEKQMNF
                     LSAYMDGFAKKIAEAFDLAALHGLEPKTMTDASFRTTNSFDGLITGNIVNYTEEHIDD
                     NIDAAVQTIVAKGGEVTGIALSPTAGQALAKVKVNGVVQYPEFRFGQNPDSFYGMKSD
                     INKNLTVTGGTAETDHAIVGDFQNRFKWGYAENIPMEIIEYGDPDGAGRDLKAYNEIC
                     LRAEAFIGWGILDEDAFARVKA"
     gene            complement(10517..10981)
                     /locus_tag="VXE25_001003"
     CDS             complement(10517..10981)
                     /locus_tag="VXE25_001003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4355 domain-containing protein"
                     /protein_id="HEV0771483.1"
                     /translation="MSEFKTIETQEELDNIVKERLRREREKFGDYDDLKKRVSELESE
                     NGALKATVEETKQTIAKSDAQITELQGQVSNYETASLRTRIALQNGLPYDLADRLQGA
                     DEEALRADAERLAGFMRPATPQAPLRDTEPAIGDDKTMQMKQMLRDLQPKGE"
     gene            complement(11064..12476)
                     /locus_tag="VXE25_001004"
     CDS             complement(11064..12476)
                     /locus_tag="VXE25_001004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000101482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="terminase"
                     /protein_id="HEV0771484.1"
                     /translation="MARKKLGNQNPTQSVILKYVKKNSKAKEAIEIYERTGLSCYAWQ
                     INLLTSIMAVDKDGLWVHQKFGYSIPRRNGKSELLYLFELWGLHNGLNILHTAHRIST
                     SHSSFEKVKRYLEKMGYVDGEHFSSIRAKGQERIELFDGGGIVQFRTRTSNGGLGEGF
                     DLLVIDEAQEYTTEQESALKYTVTDSSNPITIMCGTPPTPVSNGTVFTNYRKTCLFGK
                     GKYSGWAEWSVSEEKEIDDVEAWYNSNPSMGYHLNERKIEAELGDDKLDHNVQRLGYW
                     PEYNQKSAISETEWNELCVDSMPDLSGKLFVGVKYGQDGANVALSIAVRTVDERIFVE
                     TIDCQSVRNGNDWILDFVKRADVATIVVDGASGQKILDEELKKERMKSVILPTVKEII
                     VANSMWEQGIYQKTLCHAGQPSLKKITTNCEKRNIGSNGGFGYRSHFADMDISLMDSA
                     LLAHWACMTTKPKKKQKISY"
     gene            complement(12527..12757)
                     /locus_tag="VXE25_001005"
     CDS             complement(12527..12757)
                     /locus_tag="VXE25_001005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000528509.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771485.1"
                     /translation="MGNTIYFLEKKSSLERGASVKEILEENLEASHDYTSVLVVSLDK
                     DGEINLGYSWDSSLQALGMLDVAKNYILNVIN"
     gene            complement(12810..13049)
                     /locus_tag="VXE25_001006"
     CDS             complement(12810..13049)
                     /locus_tag="VXE25_001006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000834150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771486.1"
                     /translation="MKSDYEEVNWSEYCYKENDDDKTWWVDTSWYAKGLMLITFDKKK
                     FYNLFEDYPQNMTSEEIEIFDKENPFWEDFFSDRK"
     gene            complement(13039..14430)
                     /locus_tag="VXE25_001007"
     CDS             complement(13039..14430)
                     /locus_tag="VXE25_001007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000228949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771487.1"
                     /translation="MVEDIVPSLLKKIKSEFEGARLDSEVLKDLLSKLQHSKASYLDA
                     NQYAIEIGEILSKALGASLTNETLPDGKMYYNIAQRVLTDVLGRNYELVSDYTEQVQK
                     NLNSEAKIGLTAQVPELNQDRIDGLVNRLASEESFDDVRWLLEEPVVNFTQSIIDDSI
                     QKNAEFQHKSGLQPEIVRKSAYHCCEWCQEVQGTYKYPRVPKDIYRRHQRCRCTVDYD
                     PKSGKVQNVWSKAWSKSDKSDKIEARKNIGIQSEVSQVRKLALQIGITSNPITKSLKK
                     LTEEEIIQAISGGDKTKGSCSSLAFAYIGNKAGYTVLDFRGGKSCVFFGSIDKINMIG
                     SLPGVKMHVAKNTNDFKAVKELLEKAENGKEYYLATGRHAAIIRKNDNLVEYLELQSK
                     FVNGFKPFDDTVLKKRFKAKKSHAVRGHKYDVDSYLIDANSLKDNPEFHNILSFLNTA
                     ESKQMKGITGYEK"
     gene            complement(14423..15886)
                     /locus_tag="VXE25_001008"
     CDS             complement(14423..15886)
                     /locus_tag="VXE25_001008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000172768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771488.1"
                     /translation="MTLKGMGYLRKKLANYKMGVDTRYNQYAMQHNEIDVGITIPPQI
                     RQQYRAVLGWAAKGVDSLADRLVFREFANDEFGANEIFAQNNPDVFFDSAILSALIGS
                     CCFVYISQGDDDDAPRLQVIEASNATGVLDPITGLLTEGYAVLKRDDNGYAVLEAYFT
                     SDVTWFYPKDGKPFAIGNPTGVPLLVPVIHRPDAVRPFGRSRITRAGMYYQRYAKRTL
                     ERSDVTAEFYSFPQKYVLGLSQDAEAIDTWKATVSSLLTFTKDDEGDKPNVGQFTTSS
                     MSPFTEQLRTAAAGFAGEMGLTLDDLGFVSDNPSSVEAIKASHENLRLAGRKAQRSLG
                     SGLLNVAYVATCLRDKFPYLRKQFNKTVVKWEPLFEADANMLTLIGDGVIKLNQAVPG
                     YMDAETIRDLTGIKGDMNATPKIEEVEQKSTNSEDKQKNRIISTYEITSLLSNYQKGV
                     LSKENGILLLTSTGMSKQEAEAMINKTELIVKEAADG"
     gene            complement(16025..16369)
                     /locus_tag="VXE25_001009"
     CDS             complement(16025..16369)
                     /locus_tag="VXE25_001009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001095653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HNH endonuclease"
                     /protein_id="HEV0771489.1"
                     /translation="MNTNPLRADRSGPHRVAFEKNKKIILKTRNTCGICGQPVDKDLR
                     YPHPLSPVIDHIVPVNKNGHPSDIANLQLAHWQCNRQKSDKLYADEKTNGTKVIGNRN
                     LPQSTDWFKYKG"
     gene            complement(16603..17169)
                     /locus_tag="VXE25_001010"
     CDS             complement(16603..17169)
                     /locus_tag="VXE25_001010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000754954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HEV0771490.1"
                     /translation="MKKVEPIRDLDDIERIKDYLKNKSDRNYVLFMFGIYSGLRVSDI
                     VPLQVKQVIADRIELKEKKTGKIRYFPISPPLRKEINRYIKDNQLAEYDYLFPSKKKK
                     RTDGVRITHIGRVAVYQILQDAAKYVGLNHIGTHSMRKTFGYHHYKKNSNVAILQKIF
                     NHSTPDITLGYIGYSQDELDQSILSFDY"
     gene            complement(17459..17887)
                     /locus_tag="VXE25_001011"
     CDS             complement(17459..17887)
                     /locus_tag="VXE25_001011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001165370.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HEV0771491.1"
                     /translation="MQIELLDIIDEKKTRKEAIKVLKKYSRLRRIAGEEYAPKITISY
                     SLEPRSSSGQTSKQVESMVVRRVSAQQDLELIAKAINNLSDMGYTRILIERYCRKKRR
                     EDYSIYSELGYSSSEYYRILNKALLEFAESYQASNLLVYK"
     gene            complement(17960..18190)
                     /locus_tag="VXE25_001012"
     CDS             complement(17960..18190)
                     /locus_tag="VXE25_001012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000998323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEV0771492.1"
                     /translation="MNDKLNPRQASRFAFLLKQKRKERKLSQEKLAAKLGYSRYLIAQ
                     WEKEESVPDIYNVEDICTYFAFPADIILGSRA"
     gene            complement(18183..18359)
                     /locus_tag="VXE25_001013"
     CDS             complement(18183..18359)
                     /locus_tag="VXE25_001013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000005959.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771493.1"
                     /translation="MSEYALYQGDVFITLGTLAEISKETGIAERMLKYYTFASTQRRN
                     PNGRAVVKIEVDDE"
     gene            complement(18352..18750)
                     /locus_tag="VXE25_001014"
     CDS             complement(18352..18750)
                     /locus_tag="VXE25_001014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000612384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771494.1"
                     /translation="MIPKFRGLSIDEKSKGEWQYGHLIEDRGRAFIINEVVEANEQYI
                     TIGSWCPVNPATLGQSTGLRDKNGKEVFIGDIVKCTRGCLHEVYLEKEYGGTFIGGMP
                     SIYLKGLLSGYAWTEDEEIIDWLIEEMEHE"
     gene            complement(18762..19040)
                     /locus_tag="VXE25_001015"
     CDS             complement(18762..19040)
                     /locus_tag="VXE25_001015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813036.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771495.1"
                     /translation="MKRLGIIIGAVFVIVVSPFVVQYGWNEIITTIVPVGKITVWQAL
                     GMDALLSFIWPVLSSKKESEEDYSYAVKSSISKIITCAFLIWLASLFI"
     gene            complement(19142..20224)
                     /locus_tag="VXE25_001016"
     CDS             complement(19142..20224)
                     /locus_tag="VXE25_001016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000670043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA cytosine methyltransferase"
                     /protein_id="HEV0771496.1"
                     /translation="MKFLDLFAGIGGFRLGMESAGHKCIGFCEIDKFARESYKAIHNT
                     KGEIELHDITAVSDESIRGIGSVDIICGGFPCQAFSIAGNRRGFEDTRGTLFFEIARF
                     ASILRPKYLFLENVKGLLNHENGVTFETIISTLDELGYNVEWQVLNSKNFGVPQNRER
                     VFIIGHLRRERTRRFFPLSGKNQSTSNQSVMKIGNINPSGNGMNGEVYQADGLAPTLT
                     TNKGEGQKIAIKSNTIKQFGVLQPNFNQCGVVYETDGIAPTIRAYQGGGLEPKIIQRG
                     HGYNKGGEHDIAPTLTSNSYHENNHLSDGFRIRKLTPRECWRLQGFPDWAFDKAQEVN
                     SNSQLYKQAGNSVTVNVIAAIAKELS"
     gene            complement(20255..20542)
                     /locus_tag="VXE25_001017"
     CDS             complement(20255..20542)
                     /locus_tag="VXE25_001017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000194860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771497.1"
                     /translation="MTQTLEEGMKNQSKCIKVPREIRPFDIGYRIVNKYGQALALRNG
                     ASIFDLPFLAEKAIEKEFGKNDPDFDIGKHSVEEVAIVNLSKFHSYFEERV"
     gene            complement(20542..21129)
                     /locus_tag="VXE25_001018"
     CDS             complement(20542..21129)
                     /locus_tag="VXE25_001018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001030727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1642 domain-containing protein"
                     /protein_id="HEV0771498.1"
                     /translation="MNKDLIETPRFNFFIGDEVLLKGKIVGFDVDENKCVENVVRLEY
                     GQTLNVPNNNIYITDDIVDKSKIKVVVPQFVADWYEENKDSFEFNVWDWIAFRDEAKK
                     SENREFNNWINNSRENPIQTLVNMHQFGYEVEEEKRYTVVTKATKQPLYYNAMDKKLF
                     FSMGGLATKFTRKQLKEADFGWVFDCPGIEIEEVE"
     gene            complement(21122..21814)
                     /locus_tag="VXE25_001019"
     CDS             complement(21122..21814)
                     /locus_tag="VXE25_001019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001041154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1642 domain-containing protein"
                     /protein_id="HEV0771499.1"
                     /translation="MNVQRLIEKYKKLEGVWDAEGAELARQIFLEDLKQLDESEIGYA
                     DEAPRYVKNILARLRELPLHDREVWLKAIMSEFEQDFSRAKWREGYEQGKIEGMVERE
                     KVKVPRFVAEWIEEARKACKDVVELFEFDFTNDEVRKWFMQERPFDLVARAWLDGYEV
                     EEEKRYFVKIKGNIKENMLVYGELFKRYFFTKSFSLDDVIYSHTRKELEDANFGWVFD
                     CEGIEIEEVENE"
     gene            complement(21816..22133)
                     /locus_tag="VXE25_001020"
     CDS             complement(21816..22133)
                     /locus_tag="VXE25_001020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000969666.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771500.1"
                     /translation="MMEELKQKVNEVYNWTVEDGKPQPPKQDLPQAVKDRADYFWEMA
                     EDGMTFMGAMECIFADEKPTDYELGATKDWLPKSKEFDDWVGYSPSMAQVVIAVYLIY
                     RGN"
     gene            complement(22105..22314)
                     /locus_tag="VXE25_001021"
     CDS             complement(22105..22314)
                     /locus_tag="VXE25_001021"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771501.1"
                     /translation="MNYDKRTVIDGLKRTIEQNEEKIIEYSKPCDARKRRIRALERDL
                     LKKKNKELRRKVKKLEDDGRVKAKS"
     gene            complement(22304..22468)
                     /locus_tag="VXE25_001022"
     CDS             complement(22304..22468)
                     /locus_tag="VXE25_001022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000233204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771502.1"
                     /translation="MVGVTYQEIHLFVEFLKEQYGQGRPDYIEALNDLDGLVEVSYRE
                     AIERFLEDEL"
     gene            complement(22822..23016)
                     /locus_tag="VXE25_001023"
     CDS             complement(22822..23016)
                     /locus_tag="VXE25_001023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000470305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771503.1"
                     /translation="MFILRHGTREDKPFLRSVVIGVTGLDISCSEEKKAMRFVSRGAA
                     VQVGKALRGSFGNFYPVEVE"
     gene            complement(23031..23801)
                     /locus_tag="VXE25_001024"
     CDS             complement(23031..23801)
                     /locus_tag="VXE25_001024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000228202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HEV0771504.1"
                     /translation="MVDNVFDEIALSYHRNTEQQKELCDKHNIPLIKILRTESVVCRM
                     CESERIHEENQARVNELADAENERERKYYLEKFSLYDEVLKNATLDNFETPTEKETEK
                     LVFAKRICREWSEGARNNIVLQGEAGTGKSHLAFAMVKALSEYTKEIAIFINVTDLLM
                     KIKADFSQEEFLVNKIASAKFLVLDDLGMEKDSEWSFTILYNILNKRSNTIITTNLTS
                     ADIQKRYGRPFMSRLMKGVDKDHLMVFNDLTNKRKQYF"
     gene            complement(23795..23953)
                     /locus_tag="VXE25_001025"
     CDS             complement(23795..23953)
                     /locus_tag="VXE25_001025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000511765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771505.1"
                     /translation="MGILELIEQFEIDYYPLSYEKKTLLANQPIHQVVACLSEMASWH
                     ECGGRLSW"
     gene            complement(23941..24729)
                     /locus_tag="VXE25_001026"
     CDS             complement(23941..24729)
                     /locus_tag="VXE25_001026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863062.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage replisome organizer N-terminal
                     domain-containing protein"
                     /protein_id="HEV0771506.1"
                     /translation="MALKNKRYFWIQLAQDFFKSKEMKLLRKIAGGDTHTIIYLKMML
                     ISLEDGGHIYYDGLADNLAEEIALVIDENVEDIKITLIFLESKGLLTRNSDRDYFLEQ
                     VPEMVGSETASTRRSRKHRELQKLHCNTIATTCNGDIDIDKEIEKDKNNKVMISSSLS
                     ENLKHSGIRINDKQHQQLLEYVGIDGMNFDMLNRAIEITSEIHQPSFKYLRGILENWK
                     KKGFTSIEQVDENDQKYKEGKNYSRPGQQNDKTSEQEVRDEWGF"
     gene            complement(24720..25018)
                     /locus_tag="VXE25_001027"
                     /pseudo
     CDS             complement(24720..25018)
                     /locus_tag="VXE25_001027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863061.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(25034..25354)
                     /locus_tag="VXE25_001028"
     CDS             complement(25034..25354)
                     /locus_tag="VXE25_001028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000462832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771507.1"
                     /translation="MFEPPILDQLMGVGALLLGFAGACRHIKLQEQRKEEERREEQEF
                     ASMIIRGYNHAYERGREAERQEIRKNIRRPFKGFTYDNEPPVGLRPEPLALPEPKQSA
                     IRFL"
     gene            complement(25440..25697)
                     /locus_tag="VXE25_001029"
     CDS             complement(25440..25697)
                     /locus_tag="VXE25_001029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000370958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HEV0771508.1"
                     /translation="MDNVLLSLSEWIKSIIKDTITRLVEIEKDSDHYPELMDVNTTCE
                     FLGIKYATFSDNYRYLKGFPKELPGKKWSKRAIKEWLSNQI"
     gene            complement(25710..26420)
                     /locus_tag="VXE25_001030"
     CDS             complement(25710..26420)
                     /locus_tag="VXE25_001030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001002349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ORF6C domain-containing protein"
                     /protein_id="HEV0771509.1"
                     /translation="MNEIFNFHGQEVRTVMFDDEPWFVGKDIAEILGYVNSRDALAKH
                     VDEDDKLTSQIATAGQMRNQTVINESGLYSLILSSKLPQAKEFKRWVTSEVLPAIRKQ
                     GGFIREDLDEDAFIALFTGQKKLREQQTSMLEDIDYLKSEQPIHPSYAQSLLKKRKAR
                     VVACLGGIDSPAYADKIFAQSVFRQAEIDFKDHFNISRYDLLPKKHADAALAYWMTWE
                     PSTNTKMKIMKLNSFDEG"
     gene            complement(26448..26663)
                     /locus_tag="VXE25_001031"
     CDS             complement(26448..26663)
                     /locus_tag="VXE25_001031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000248658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HEV0771510.1"
                     /translation="MVNVSKLKGKIIERNTTQEALAKDIGIDKSTFYRKMKQNGSFSI
                     QEVNLIVSSLGLSKDEALSIFFSETVA"
     gene            26829..27563
                     /locus_tag="VXE25_001032"
     CDS             26829..27563
                     /locus_tag="VXE25_001032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001100508.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEV0771511.1"
                     /translation="MNVGERIKQRRKALKMSADELAESVGVSRSTIFRYEKGDIEKVG
                     PEVLKKIADKLNVSPGDLMGWEDNQQELKIPTSPLVHKITEKVVKLSTPRKQKVLNYA
                     NEQLKEQNNKVITIEEKLFEYRVFEKLSAGTGFSYFNDGNYDTVFYDKDLDHDFASWV
                     FGDSMEPKYMNGEVVLIKETGFDYDGAIYAVDWDGQTYIKKVYKEKDGLRLVSINNKY
                     KDKFAPFEEDPRIIGKIVGNFMPIEN"
     gene            27576..28490
                     /locus_tag="VXE25_001033"
     CDS             27576..28490
                     /locus_tag="VXE25_001033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690127.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HIRAN domain-containing protein"
                     /protein_id="HEV0771512.1"
                     /translation="MKIGMRKPSLTRSLKARTTSKWKRQAKKALIPGYGKKGMGWVKN
                     PKKAMYNKVYHKTTFGLSDLFKSSKKRKKKVVNNKQQSILASNGKKQHTPKEYKEAGL
                     VFMVLGAIFLFLFPPLGFFLFITGFITYIIGRLTAKREKKQKVENYSPQIDTIVFRDN
                     FLLMGTNYHQEEAEIAADFLSKGVHYFGKDNKSLKSYMLETYKPVYKYNKLKTVDVQL
                     LPEPSNPHDKNAVKVLVNNIFVGYLPAVIASQISSYISNPNYRYDAILTGRGGPYKTL
                     NIETERVVSRKSDLTYYLDLTVWRLAKK"
     gene            28662..29810
                     /locus_tag="VXE25_001034"
     CDS             28662..29810
                     /locus_tag="VXE25_001034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000876726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HEV0771513.1"
                     /translation="MKYNKTKYPNIYYYETAKGKRYYVRRSFFFRGKKREKSKSGLTT
                     LPQARAALVELEQQIQEQELGINTNLTLDQYWDIYSEKRLSTGRWNDTSYYLNDNLYK
                     NHIKAKFGSTLLKNLDRNEYELFIAEKLQNHTRYTVQTLNSSFMALLNDAVKNGNLLS
                     NRLKGVFIGQSDIPAANKKVTLKEFKTWIAKAEEIMPKQFYALTYLTIFGLRRGEVFG
                     LRPMDITQNDSGRAILHLRDSRSNQTLKGKGGLKTKDSERYVCLDDIGTDLIYYLIAE
                     ASKIKRKLGIIKEQHKDYITINEKGGLINPNQLNRNFNLVNEATGLHVTPHMMRHFFT
                     TQSIIAGVPLEQLSQALGHTKVYMTDRYNQVEDELAEATTDLFLSHIR"
     gene            complement(30052..31338)
                     /locus_tag="VXE25_001035"
     CDS             complement(30052..31338)
                     /locus_tag="VXE25_001035"
                     /EC_number="6.3.4.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017279.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylosuccinate synthase"
                     /protein_id="HEV0771514.1"
                     /translation="MTSVVVVGTQWGDEGKGKITDFLSANAEVIARYQGGDNAGHTIV
                     IDGKKFKLHLIPSGIFFPEKISVIGNGMVVNPKSLVKELSYLHEEGVTTDNLRISDRA
                     HVILPYHIELDRLQEEAKGDNKIGTTIKGIGPAYMDKAARVGIRIADLLDKDIFRERL
                     ERNLAEKNRLFEKLYDSKAIVFDDIFEEYYEYGQQIKKYVIDTSVILNDALDNGKRVL
                     FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPSKIDKVVGVCKAYTSRVGDGP
                     FPTELFDEVGERIREVGHEYGTTTGRPRRVGWFDSVVMRHSRRVSGITNLSLNSIDVL
                     SGLDTVKICVAYDLDGQRIDYYPASLEQLKRCKPIYEELPGWSEDITGVRNLEDLPEN
                     ARNYVRRVSELVGVRISTFSVGPGREQTNILESVWS"
     gene            complement(31569..31805)
                     /locus_tag="VXE25_001036"
     CDS             complement(31569..31805)
                     /locus_tag="VXE25_001036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase RecX"
                     /protein_id="HEV0771515.1"
                     /translation="MLQKIYEQMANFYDSIEEEYGPTFGDNFDWEHVHFKFLIYYLVR
                     YGIGCRKDFIVYHYRVAYRLYLEKLVMNRGFISC"
     gene            32071..32932
                     /locus_tag="VXE25_001037"
                     /pseudo
     CDS             32071..32932
                     /locus_tag="VXE25_001037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014632353.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(32967..33176)
                     /locus_tag="VXE25_001038"
                     /pseudo
     CDS             complement(32967..33176)
                     /locus_tag="VXE25_001038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(33342..33415)
                     /locus_tag="VXE25_001039"
     tRNA            complement(33342..33415)
                     /locus_tag="VXE25_001039"
                     /product="tRNA-Asn"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(33379..33381),aa:Asn,seq:gtt)
BASE COUNT         9559 a         7780 c         5610 g        10469 t
ORIGIN      
        1 tccaagatac ttactttcgc tatcgatagt agccgtatat gtactcgttg tccaaattcc
       61 tgtttttgaa atatcctgct tgaatagtga gttcaagaat agatttcgac cggatgcctg
      121 cacactcgca atccgactag ctagctcctc agctgtctgc gtgagttctg acttgctggc
      181 tttatccttg gttgcattca ggatttcctg acggatagag ccagctcgca cctcaaattc
      241 agcctgactc aacttctgat ttagcttgtt ctgcgtgtct gtctcaagcc tcttcacaga
      301 ttgccggata ttttcagcag tcacattgag tgagctgata tccactttgg ttctaagccc
      361 ttcagtcaag cttctcacac cagcgtcgag cgagttggct cgttgtttaa aggtcgattc
      421 tactgttgaa atctgacctt ctatatcttc aggagcttct tttgagcttg ttgccaaact
      481 tccgtcttcc agctggggcg caagaacatc taaatattct ccgacttcag catttacgag
      541 atacacatag ccaattgatg cgactccagc cctatttcta gcgctagtaa acgatagctt
      601 tgtccaattt tcatccttta atgtaaagat gggcgaaata cccgaattat cattgacttg
      661 ccaataagtt tgtagcttga ccttttgacc tcttctgcct ttgacccaac aagacatcgt
      721 gtatgtgcct tgcgagatat gaaatccatc ttgagcaata cctatttggt ctctagcatt
      781 gcttgaggtc aatcgtatcg ctttatcaaa gccagttgct ggactgtctg atacatcaat
      841 cgtctttgcc gtcccagcgc ctgacggtct aaaagtacct gatgcccaca atcctctggc
      901 tagcatcatg cgctttgtac cccggatata attcctaccc ccgacctgca cactcgctat
      961 cttactagcc agttcctcag ctgtttgcgt gagttctgac ttgctggctt tatccttggt
     1021 tgcgttcagg atttcctgac ggatagagcc ggctcgcacc tcaaattcag cctgactcaa
     1081 cttctgattt agcttgttct gcgtgtctgt ctcaagactc ttcacagatt gccggatatt
     1141 ctcagcagtc acgttgagtg cgctgatatc cactttggtt ctaaggcctt cagtcagacg
     1201 attcacacca gcgtcgagtg aatcagcacg ctgtttaaag gtcgattcga ctgttgagat
     1261 ttggctttcg acatcttcag gagcttctga ataagaagta tctacatcgc ttatttcgaa
     1321 cttcggcatc caaatccaaa cggttccttc ctggttgaaa ttgaacaacc attcatttgt
     1381 ggtctgcttg gattcgtttg tccaaccttt tggaatatgg acaacatatc gcttaatttc
     1441 tgtcgacaat gtcacatttc cagttttata tccgatattc cctaatcgag atctcagcat
     1501 tattccattt ttatttgcct tagcataaaa actaatggtt acatcttgat tagtcgtact
     1561 tccgggaatt actttcccga attgacccag agctggataa gtaaccttgg gattccctcc
     1621 atcacggcca gatggattca aacctataat tttaagagcc ttgtgtccaa gatacttact
     1681 ttcgctatcg atagtagccg tatatgtact cgttgtccaa attcctgttt ttggaatatc
     1741 ctgcttgaat agtgagttca agaatagatt tcgaccggat gcctgtacac tcgcaatccg
     1801 actagctagc tcctcagctg tctgcgtgag ttctgacttg ctggctttac cattggccaa
     1861 gttggtcagt tctgacagtc tacgagtcgt cgtctcctca tacgtcgctt gcgctgactt
     1921 cacgccagcc agttcatttt tagtccggct aagtgcttca acttgcttgg caatctcagt
     1981 ttcagcctgt gcttgcttcg gtcgaatatc attcgcgata gtccgtttca gagcgtccaa
     2041 gtcacccgac agagccgttt gtgcgctcgt agtctgcgac ttaaacgctt caagtctagc
     2101 aacagaatcc agctcaatcc gcttagcttc ctgtgcaagc agggtacttg cgccagccag
     2161 ttcttttttg gtctgaacaa gtgcttcaac ttgcttggca atctcagctt caacctgtgc
     2221 ttgcttcggt cgaatatcat tcacgatagt ccgtttcaga gcgtccaagt cacctgacag
     2281 agccgtttgt gcgctcgtag tctgcgactt aaacgcttca agtctagcaa cagaatccag
     2341 cccaatccgc ttggattcct gagcaagaga actacttgcg ccagcatttc gcaaagcttc
     2401 ctcagccttg cgcttagctt ctttcaatgg cccgttgtca aagctattaa agcgctgatt
     2461 gatagtgtca gacagttctt gcttgacttc ttccgctttg gccttggcaa gttcgatggc
     2521 atccgtgatg gttttctcac gcttgaaaaa ttcagcgtca aaggcacggt cagcgttggc
     2581 gatttccttt ttcaaacgtt cttcaaaaat ctgatgcaga tttcggcttt cattcaaaac
     2641 ggcatcattt acaatcccac cgatcgcatt tgcaagactg gactggaagg ttccaaaacc
     2701 tattgatttt aggagttttg ccattggcga ataggtatat ttggtgattt tcttacgaac
     2761 atcaagaccg taccactcat ggtagaaact gaccacatca aacatctgca ccgcaacatc
     2821 actctgaccg acaaccgaga tttcaaggtt atcttctagc atgtcgcaca tacttgtccg
     2881 aaaatactgc ttaccgtatt caatcaagct agcctcatct gtcacgtctt ggtcattgac
     2941 ttccaccaca tcttcgtaga tttggctgta gttcccaagt aaggggctgt caatcaccac
     3001 catataatca tggtcaaccg cattttctcc ctcgccctta acagtcgttt taaaggttat
     3061 ccgagttttt aaagacttcg ttgaggtctt atgctggtag ctggacaagt ttttcttgta
     3121 cataaaaagc gattcatttt cagaaccgcc attcttcaac aagcgtaaat tgtagccgtt
     3181 tcgcaccata tctccgcccc actgaccaag gatagaatgc ttgcctttgg ccaagacctc
     3241 catggcattc ttatccttga tattgagcgt atgcctatca tcaatatcag agaagaaaga
     3301 aaaaggattg gctctggtaa tactaccagc aaaagcactc aacacccttg tcccactgac
     3361 acggtcaacc tcgatagagc taacgatgta attatttaac aaactgataa cctgattggc
     3421 atagacttga atatatcctt gttgcttttc aacctcaaaa atataaaaat cctgctcacc
     3481 atgcaggtca tctgcagtca gaaaagtttc ctctttcagt aattcccact tggtatccga
     3541 tgtaggaaaa cgaaaggtca gttgataggt attgttcccc aaatggacaa tttcatcatt
     3601 gtaggcctca tttaaaggtg tattgccttc agtaagataa atcataagat atacctccaa
     3661 ttcggccgaa ccgtgacctt gcgaaccgaa ccagtaaaga ccagactgtt attaccaact
     3721 gccaactcaa agaagcctcc acgtttacgt aaagtatttt gaaccgcgcc atctgcatta
     3781 tagatattct gtttcttatg cctacaatca atggtcactt ttcgtctaac ggtcaagtgc
     3841 atagttgtcc ttccgatagt caaagaaata tcaccgtctc cctcaatctc aatcacaggc
     3901 tcgctataga cagagcctgg attgttgata tttccacttg cggtaaagat aagaggagca
     3961 acatttttct gataacggaa cggttgcatg ttcaacttga tttctagttt ccaggcatgc
     4021 atcccatgag ggctataggt tgcaccaata aaatccgcat aaaatacaga ccccaactgg
     4081 tagctaaact ctagcacatt gtccttaggc tgaaatttct ccacgatagt agaaacatcc
     4141 agtaacttag gaatatagaa cgaaaaagtc cgttcataac tctcatagcc accatccagc
     4201 actcgataac ttccgttggc tccgtagagg ttagcatctt cagccaccct aggtttagct
     4261 gcctccacct gaccaaaatc cgtcaccacg cagtgaggga tagttgatgt attaaaccca
     4321 ttgataatca tataaaacat tacattccct ccctagcata aatcgcacct tgacgttggt
     4381 agacgctcat tgaaatttta tcagcgtcta ggtaagtatc tgacggcttt tcaaggatag
     4441 cagtaaggat tttctccata cttgctctca gaatcgctat ctcagacacg gtttgactgt
     4501 ctttcgcctc gatttgagcg cttggcatgg ccaaacttgc ttcaatattt ttggcaatag
     4561 tcggtgttcc actcaagcca aaatcatcgt ttgaaaatgc gtttgaaatt tcgccagcca
     4621 ttccactgac agatttctta acatctttga aacggtcctg caaccctcta tccaaacctt
     4681 gcataatcgc attaccagca ggaatcaaga gcttgcggtc atactcaatc ggacctttgt
     4741 ggtcacgaat ccagctagca ataccaccaa cgaagtcagt tactgctccc caagcagact
     4801 tcaaaccgcc taggaatcca tcaaggatag ccttacctgc tgaccatagg tcaatgtttc
     4861 gaatgccatc aaagatactc gtaacattac ttacaaggtc acgaacacct tgtttcatgc
     4921 tttcccatgc atttttagct ccttggacaa gtccgtcaat cagacctaag acggttgatt
     4981 tcaacccttc ccaagcactg cttgctacaa atttgattgt attccagatg ttagataata
     5041 tctgagcaaa actatcaaag atagctttac ctgcagcaga caaccctttc caaattgtac
     5101 taagagtggt agaaaagttt tcaaaaatag caataccata acctacgata acatccacga
     5161 ctccagagaa gtatgtttta atcccttccc aaatcataga gatactattt ttaatccctt
     5221 tccagattag agaaagatca gcccccagct ggttaaaatt ccctgtcaca aggttgatga
     5281 tgatgagaat agcacccaag aaaatagact tgatgaattc ccaaacgcct tggaaaatca
     5341 tcttaatccc ttcccaaatt tgggtaagac catctgaaat attgttccaa atattcatga
     5401 atccatcaat gaacggttga acaatagcca tcactgctgt tgtgatagct gtccatgcca
     5461 cagatgcagc ttcttgaatc cttacccaca agtcagaaaa gaatgttaca acagcattcc
     5521 aggctgtaac aactccatcc cacaatgtgc tagcaccttc agagatgcca gaccaaaggt
     5581 ttacaaagaa atcagcaatc ccctgccaag cctgtttgat ccaagctaca aaagatgacc
     5641 agatttgtct acctgtttca gtttgagtga agaaataaac caaacctgca gttagtcctg
     5701 caatcgctgc gatggcaatt ccaataggat tggcactcat tacagtaaat agacccgtga
     5761 ctgctgtttt aattgtcgtt aagacagcag gtattccaga tagcaatccc gagactgtcg
     5821 aaaatgcttt aaacgctaaa aatgcagaac caagagcggt aacgatacta cccatgatac
     5881 ttcctagacc ttcaccaaag attccactga aaacaccctt tatccctccc aaaataagga
     5941 taggaatttg tttcagaata tttccaatca ttggaattag gtttccgaaa agaaatgttg
     6001 atgtcgtttc catcaaagct tgtagtgcag gttgaatatc ttcacctaaa gacaactttc
     6061 caagcacatt ctgagcagct gatttcatcg attcaaatga acctgtaaat gtagttgctg
     6121 cctctctagc tgtcgtacca gtgatgtcca aattctcttg tatagtgtga atggcgctat
     6181 aaacgtctga tagattattg atgtcatatt taacacctgt caatttttca gcatccgcca
     6241 aaagtcgttg catttcttgc ttcgtaccac cataacccaa tttaaggttg tctagcatcg
     6301 tataattttg cttggcaaaa ccttgataag ccagttgaat gctttccata gatgtcccca
     6361 tcttattggc attatccgac atatcaatca tggccatgtt agctgtttct gctgctttat
     6421 ctgtatctcc accaagagat tgtagcaagc ttgctgagaa acctgtaaca ttttccatat
     6481 aggcattggc tgagagacct gttgtcttgt aagcctcgtt cgcaaatcct ttgaccttat
     6541 cagctgagtc tttaaataag gtttcaaccc ctccaagaga ttgttgaagt gctgcccctt
     6601 cgtttatcga tgctccgatt gctttaccaa ttccagctgc agcaataact cctgaaacag
     6661 cccccatcat tttagaaccg agggattcgc ctgcgctaac gccagctgag gcaacttcac
     6721 cacccatttc cttttgaatc atgccactaa tgcctttagc agatggaatg atttgtacat
     6781 aggcttttcc taattcggtc gccactaatc ctcacctcct gtttttgcaa gcaaagcctt
     6841 gcgatagttt tcaaagtcct caccagattc aaagacgaga taatcccttt catctccctc
     6901 ttctttgtta ttctttgtaa gtaattcagc aattgatgca ggacgattaa cacccttttg
     6961 cccatctttt gttttcaacc acaaagaaag agacagtctg tctacgatac ttgcaagtaa
     7021 cgtcgtttca agagggacga tttggtcaga catcatctgc tttatccgcg aatcatcacg
     7081 caacccatac gcaaaaacag ccacctgatt taaaggtagc tgtttatagt cgtatatttg
     7141 gtaggtttcc gctaaatcac agataagagc atcctcgtct aaggcaatca tctgagcaag
     7201 gactaagatt tttttaggtc tttgttggac tcaaagatac tcttgatatc tgcgaacagt
     7261 acctcagtat cgatgaagtc gtctccatca tctaaatgag ataaaaactc ttccgcttgt
     7321 tttttaccaa agagaagatt cagcaatttt tcagcagctt caaaatcccc cttctccatt
     7381 ttggaagctt cgcgcatgag ataaaagttt ctcaatcgtt ttttagggat tttgtactca
     7441 aaccctgact ctgtttttcc ttttaagatt tcttccattt attttacgct ccttgaatgt
     7501 attcgtagtg agtgttttca ctgttgtctg gtaatgcagt gatcgtcaat tcatagccga
     7561 taggttcgcc gtctttatag ctgatttcgc caatttcgct aaccttacca cgaggaatga
     7621 caacgcgttt cacatagcca tttttcagca aagtatcaat aaccaagcaa tgttctggca
     7681 actctttacc gttggctttt acagtgatac ctgtttcaag cgttcctgag acgttatctg
     7741 gtccatagac ttctttcaag actttaatgt tcagaccttc aattaatttg tatttgaagg
     7801 tatctttctt ttcagtttga gaagacaaga ctgtttgtcc accccacgct ttgattgctt
     7861 tgctttctgg cgagttcgca ttggtcaatc catcatctga aatgtaccct agcgtttcaa
     7921 atgctgcatc caaatctgtt ttggcattcg ttggaagagt tgttccagct ggagcagtag
     7981 aaactgcccc tccaattttc ggcttagcag ccgttacatt tgatgctgat gcagtcgtca
     8041 tattctttcc tcctgttgat tctgtatttt gtcttcttgc ttctgtcgtc aaaactacac
     8101 ctccttttta aaaataatta atgtcatata ccgcttgata gcgatattgc ttcgtttccg
     8161 tgtctgtaaa gttgtagtca ctattgtgat gcacaccgct gacttcgttg accgtgatga
     8221 gatcctcaac tactttcttg actttctcat tcagctcagc agccttttga agtgatggtg
     8281 cataactttg aaaagcgaat gtagcggaat gaacgtagtc gcttccacca cttccagtct
     8341 tttctaaaat gacataactc tcaggcatat tcggtttatg ttcaaaaaaa gacggtacat
     8401 ctaactgtcc gtccaaaaat ttctttataa ctaattcgat catctcatag ccttcagtaa
     8461 aatattatgt tttttatttc tagccatgct cttgatatca gtcgtactaa tctttgcatt
     8521 ggcacgcttt tgccctggcg atacagtcaa ttcaaacccc tcaccagctc tttcagcaat
     8581 cccttgccct ttctccctca aaataccctg catttcggaa gaacgtagca aggcagacac
     8641 cccagccgag ttcaattgaa atttcatatc actcataaac ttcaaccata acctttctat
     8701 tccacgataa tggaatcatt gactcaatcc cctcttgagg gatgccaatc gtccgccatt
     8761 tacgaccaaa aaacttaacc tcacggttct cccacttgtt agtgtctcct ttaggaatac
     8821 caagtgtata ttccgccttt ttcccagtca aattcatttg attgatgacg tcctctgatg
     8881 aagttgggac aaccaataca ttttgaacct caatctcaac atcacgatgg attggatgac
     8941 cgaaatcgtc attaccagtt tccaccttgt ctattaaaat gacagggatt ccttttaggt
     9001 aggtcataaa tttcaatcgc tccatatcgt tgttttttct tcaaaccaag ccttttaagt
     9061 tcggtgtctt tgataaagag accgcctcca gggacaaggt acgaaccact aaacgaataa
     9121 cccaaggcac tttcagatac ctgagtcatt ggttcatggt ctgttgaggt catgagggtt
     9181 cgtgccacga tatcgaccgt gacagacttg gcaacactag cgaatgacac gctctcagct
     9241 accatatcgt caaggtcttt accgactttt tcagcttcca ctcgcaaaga attagataca
     9301 acttccaaca aagcctcagc ccttgcacgc tcatcaaatt tcaacgagcg ccataacaat
     9361 tccaagtctt caatctttgc aaaagttccc atagcttaac tcttattttc ctcgtacaag
     9421 gctaccaaat cggatttttt tgaaccctta tcgtaatcaa cgcccaattc atccaaacta
     9481 gacttcaatt ccgctacggt caaatccgct ccgcttggcg ccgtatcttc aacaggcacc
     9541 caatctccgc caagaacact ctcagcagag ataatcacgc ccgttttcgt atcacggtat
     9601 aaagccataa aacttacgct ttcacacgag cgaaggcatc ttcatcaagg ataccccagc
     9661 caataaaggc ttccgcacgc aaacagattt cattataggc tttaaggtca cgaccagcac
     9721 cgtctggatc accgtattca atgatttcca tcggaatatt ttcagcatag ccccatttaa
     9781 agcggttttg gaaatcccct acaatagcgt ggtctgtttc agcagtgcca ccagtcacag
     9841 taaggttctt gttgatatct gatttcatac cgtagaatga atcaggattt tgaccaaagc
     9901 ggaactcagg atattgaaca actccgttta ccttaacttt cgccaacgct tgaccagctg
     9961 ttggtgataa ggcaatacct gttacttcgc cacctttcgc tacaatcgtt tgaactgcag
    10021 catcaatatt atcatcgata tgttcttcag tatagttaac aatgttacca gtaatcaatc
    10081 catcgaatga gtttgtcgta cggaaagaag catccgtcat tgtttttggc tctaaaccat
    10141 gaagagcagc aaggtcaaag gcttctgcaa tcttcttagc gaatccgtcc atatatgctg
    10201 acaagaagtt catttgtttt tcttctgaag cgtatttgaa ctcatctgtg atacgagctt
    10261 gataaacaaa tttaagtggt ttgattactt tagaagtgat tttagcttta ccagcttgtt
    10321 tttgttcacc ttctccaacg atttgagcat ttccttcaag gttgaagata aattgctcca
    10381 ctccattaaa tggaatcggg gtctgagatg agagtttagc aagaacagaa cgtccttgta
    10441 ctttgctgat taattctttt actagttctg gtttaaaaag tgttccagct ttcgttgcat
    10501 tatctgccat aattttttat tctccttttg gttgtaaatc tcgaagcatt tgcttcattt
    10561 gcatagtttt gtcatcaccg atagcaggct cagtatctct tagtggtgct tgaggggttg
    10621 ctggtctcat aaaaccagct agacgctcag cgtcagccct taacgcctct tcgtcagcac
    10681 cttgaagacg gtcagccaag tcataaggca agccattttg taaagcgata cgagttcgta
    10741 agctagcagt ttcataattg ctcacttgcc cctgcaattc agtaatttga gcgtctgatt
    10801 tggcgattgt ctgttttgtt tcctcgacag tagctttcaa agcgccattt tcagactcta
    10861 gttctgaaac acgtttcttg agatcatcat aatcaccgaa tttttcacgc tcacgtctga
    10921 gacgttcctt cacgatgtta tctagctctt cttgtgtttc aatcgtttta aattcagaca
    10981 tcttcatgtc tcctttctcc tgctttcccg gcagttcggt aattttttag gcatcaaaaa
    11041 aagcagtctc tcaactgctc ctcttaataa ctgatttttt gctttttctt aggcttagtt
    11101 gtcatacaag cccaatgcgc aagcaaggcg ctatccatca aagaaatatc catatccgca
    11161 aaatgcgagc gatagccaaa cccaccgttt gaaccgatgt tccgcttctc acagttggtt
    11221 gtgattttct ttaaagacgg ttgaccagca tggcacaagg ttttttgata aatcccttgt
    11281 tcccacatag agttagccac gatgatttct ttaaccgtag gcaatatcac gctcttcatg
    11341 cgttcctttt tcaactcttc atcaaggatt ttctgaccac ttgccccatc gactacgata
    11401 gtagccacat cggcacgctt gacaaaatcc aagatccagt cattcccgtt acggactgac
    11461 tgacagtcaa tcgtctcaac aaaaatcctc tcatctaccg tacgaacagc aatacttaac
    11521 gccacgtttg cgccatcttg accatattta actccgacaa acaacttacc tgataaatca
    11581 ggcatagagt ccacacacaa ctcattccat tccgtttccg aaatagcaga tttctggttg
    11641 tattcaggcc aataacccaa acgttgaaca ttatggtcta gcttatcatc accaagttca
    11701 gcttctatct tccgctcatt caaatggtaa cccattgagg gattggagtt ataccaggct
    11761 tcgacatcat caatctcttt ttcctcagaa accgaccatt ctgcccaacc tgagtatttt
    11821 cctttcccaa ataggcaagt cttacggtag tttgtgaata ccgtcccatt tgaaacaggt
    11881 gtaggaggcg tcccacacat gattgtgatc ggattgctac tatccgttac cgtatatttc
    11941 aaagccgatt cctgctcagt cgtatattcc tgagcctcat cgattacaag aaggtcaaaa
    12001 ccttccccta aaccaccatt ggatgttctg gtacggaatt gtacaatccc accgccgtca
    12061 aacagttcaa tccgctcttg tcccttggct cgtatagagc taaagtgctc accgtccaca
    12121 tatcccattt tttcaaggta acgtttaacc ttttcaaaag aggaatgaga ggtagatatt
    12181 cggtgggccg tgtgtaggat atttagtcca ttatgcaggc cccaaagttc aaaaaggtac
    12241 aagagttcgg acttcccatt acgacgagga atagagtagc caaatttttg atgcacccac
    12301 aaaccgtcct tatcaacagc cataatggat gtcaacaagt tgatttgcca agcgtagcaa
    12361 gaaagaccag tccgctcgta gatttctatc gcttctttcg ccttagaatt tttcttgacg
    12421 tactttaaaa ttaccgattg agtaggattc tgattgccaa gtttctttct agccatccac
    12481 tgctcctttc aatcgtaccg catgataacc ctatcgctgg gatgatttaa ttgattacgt
    12541 ttaaaatata gtttttagca acatctagca ttcccaatgc ctgcaaacta ctatcccagc
    12601 tatagccaag atttatctca ccatctttat ccaaagaaac taccaacacc gaagtgtagt
    12661 catgactagc ctcaagattt tcctccaaaa tttctttcac ggaagcaccg cgctccagac
    12721 tagacttttt ctctaaaaaa taaatcgtgt ttcccattgt tactcctttc taagcataag
    12781 aaaagcaccc ttgcgagtgc tctaacatat tattttctat ctgaaaagaa atcttcccaa
    12841 aatggatttt ctttatcaaa gatttcaatc tcctcagaag tcatgttttg aggataatct
    12901 tcaaaaaggt tatagaactt ctttttatca aatgtgataa gcatcaatcc tttggcatac
    12961 catgaagtat caacccacca agttttatca tcatcgtttt ccttgtaaca atactctgac
    13021 caattcactt cttcgtaatc acttttcata tcctgtaata cctttcattt gtttagattc
    13081 agctgtgtta aggaaactca atatgttatg aaattcaggg ttgtctttta atgaatttgc
    13141 atcaataaga tagctatcta catcatattt atgtcccctt acagcatgag atttcttagc
    13201 cttaaatctt tttttcaaaa cagtgtcatc aaatggctta aacccattta caaattttga
    13261 ttgaagctcc aaatattcaa ctagattatc atttttccta atgattgcag catgtctacc
    13321 tgttgccaaa tagtattctt ttccattttc tgccttttcc aacaattctt tgaccgcttt
    13381 gaagtcattt gtgtttttgg ctacatgcat cttaacacct ggaaggcttc caatcatatt
    13441 gattttatca atactaccaa aaaaaacgca actctttcca cctctaaaat ctagaactgt
    13501 atatcccgct ttatttccta tgtaagcaaa tgctaaggat gaacaagacc ctttcgtctt
    13561 atctccacca ctaatcgctt gaataatttc ttcttcggtt aattttttaa ggcttttcgt
    13621 tatagggttt gaagttatac ctatttgaag agcaagcttt ctaacctgac tgacttcaga
    13681 ttgtattccg atgttctttc ttgcttctat tttatcactt ttatcacttt tactccacgc
    13741 cttactccaa acattttgga cctttccact tttaggatca taatcaacag tgcatctaca
    13801 acgttgatgt cttcgataaa tatcctttgg aactcttggg tatttgtaag taccttgaac
    13861 ctcctgacac cattcacaac agtgataagc tgattttctt acaatctcag gttgcaatcc
    13921 agatttatgt tgaaactccg catttttctg gatgctatca tcaattattg attgagtaaa
    13981 attcacaaca ggttcttcta atagccaacg aacatcatca aaactttcct cactggctaa
    14041 acgattaacc agaccatcaa ttcggtcttg attcaattca ggaacctgag cagttaaccc
    14101 aattttagcc tcagagttca aattcttctg aacttgctca gtataatcac tcacaagctc
    14161 gtaatttcgc cccagaacgt ccgtcagcac acgttgagcg atattgtaat acattttacc
    14221 gtctggtagc gtttcgttcg ttagagaggc tcccagagcc ttagaaagta tctccccaat
    14281 ttcaatagca tattgattag cgtccaaata acttgccttg ctgtgttgta gtttagacag
    14341 caagtctttc aagacctcgc tgtctagcct agcaccttca aactcagact tgattttctt
    14401 gagcaggctc ggaacgatat cctcaaccat ctgcagcctc cttcacaatt aattcagtct
    14461 tattaatcat agcttccgct tcttgcttac tcattccagt tgaggttagt aagagtattc
    14521 cgttttcttt tgaaagtacc cctttttgat agttactcag tagagaggta atctcatatg
    14581 tagaaatgat tctatttttt tgcttatcct ctgagttagt acttttttgt tctacttcct
    14641 caattttcgg agtagcgttc atatcgcctt tgattccagt caagtcacgg atggtttcag
    14701 catccatata gccagggacc gcttgattca gtttgataac accatcacca atcaaggtca
    14761 gcatgttagc gtccgcctcg aacaaaggct cccacttcac aaccgtttta ttgaactgtt
    14821 tcctcaaata tggaaactta tctcgtaaac aagtagccac ataagccaca ttcagcaaac
    14881 cagagcccag agagcgctga gccttccgac cagctaaacg caagttctca tgactagcct
    14941 tgatggcttc aacggatgac ggattgtcag aaacaaaacc aagatcatcc aaggtcaacc
    15001 ccatttcccc agcaaagcca gcagctgcag tccgtaactg ctcagtaaaa ggagacatgc
    15061 tggatgtggt gaattgcccc acattcggct tgtccccttc atcatctttc gtaaaggtca
    15121 gcaagctaga tacagtcgct ttccaagtat caatcgcctc agcatcttga ctcaatccca
    15181 acacatactt ctgagggaat gaataaaact cagcagtcac atctgaacgc tcaagcgttc
    15241 gtttagcata tctctgatag tacatcccag cccgagtaat tcgtgaccga ccaaacggac
    15301 gaaccgcatc aggtctatga atgactggta ccaacaaagg aacacccgtt ggatttccga
    15361 ttgcaaacgg ctttccatct ttaggataga accaagtcac atcactagta aaataagcct
    15421 caagcacggc ataaccattg tcatcccttt tcaaaacggc atagccctct gtcagcaagc
    15481 cagtgatagg atccagaaca ccagttgcat tacttgcctc gataacctgc aaccgaggag
    15541 cgtcatcatc gtccccttgc gagatgtaga caaaacaaca cgacccaatc aatgctgaaa
    15601 ggatcgcgct atcaaagaat acatctggat tgttctgagc aaagatttca ttcgctccaa
    15661 attcgtcatt ggcaaactca cgaaagacca aacgatctgc tagactgtca acacccttag
    15721 cagcccaacc taagaccgcc cgatattgtt gcctgatttg aggtggtatc gtaataccaa
    15781 catctatctc attgtgttgc atagcatact gattgtatct agtgtctaca cccattttgt
    15841 aattggctag cttcttcctg agatagccca tacctttcaa tgtcatttta tacaactacc
    15901 tttcatttcc cgcgagaaaa tatgtacagt gacggtgtga agccctgaag caccgagggg
    15961 gagggggtca tccccccacc ttggcaggaa cactcgtcct ttttttttaa tcacgtttat
    16021 ttttttaacc cttatactta aaccaatctg tactttgtgg taagttccta ttaccaatga
    16081 cctttgttcc gtttgtcttc tcatcagcat atagcttgtc agacttctgt ctattgcatt
    16141 gccaatgcgc caactgcaag ttagcaatgt cagatggatg tccgttctta tttactggaa
    16201 cgatgtggtc aatgactgga cttaatggat gaggatatct caggtctttg tctacaggct
    16261 ggccacatat cccacaagtg tttcttgtct ttaagataat cttcttattc ttctcaaagg
    16321 ctactctatg gggtccacta cggtccgctc ggagggggtt ggtattcatc tagggaggga
    16381 gtcctttctt tttaatggag ggggttggta ttctcaaatg tacccctcgg tatctttcaa
    16441 agtaggggtg tttttagtgc acccaccccc tcttgtattt aacatatctt atattctgtt
    16501 aaataaaatt aaacaacttc aaagtcaaga gtatcaaggc ttctaccata tttttctaaa
    16561 aactaattta cattttctca ttatgtaaaa tagataggct atttagtaat caaatgatag
    16621 tatactctgg tcaagttcgt cttgactata accgatatat cctagtgtga tgtctggtgt
    16681 ggaatgattg aatatctttt gtaggatagc tacattacta ttctttttgt aatgatgata
    16741 tccaaatgtc ttcctcatcg aatgagttcc tatatgattc aaacctacat atttagctgc
    16801 atcttgaagt atttgataga ctgctactct tccaatgtgt gtgatacgaa caccatctgt
    16861 tctctttttc tttttacttg gaaagagata gtcgtactct gctaactgat tatctttaat
    16921 gtatcgattg atttcttttc tgagaggggg gctgattgga aaatacctta tcttaccagt
    16981 cttcttctct tttagttcaa tcctatcagc aattacttgc ttgacttgaa gaggtactat
    17041 gtcgctcact cttaaaccag agtagattcc aaacatgaat aaaacatagt ttctatcact
    17101 tttgtttttc aagtaatctt tgattcgttc tatatcgtct aaatcacgaa ttggttctac
    17161 tttcttcatg tacctctcct ttcctacata aaaagccact ggtcgtggca ttgaatatga
    17221 cagtagctgg aattgaacca gctggtctag cagtaaaacg cacgtttggt aaaagtttca
    17281 cggagaccca aacaacctgc taacctgtcc ttactgtcta agaggctgaa gcctctatat
    17341 ttttaggagt cctcatgact gtacgttgcc caatcattgg ataatactat tttagcacct
    17401 ttttccgctc caattctccc aagattttcc cagatttttc ccaagatttt cccagaaatc
    17461 acttataaac taaaaggttg ctcgcttgat aagactccgc gaactctagt agagctttgt
    17521 tcaatatccg ataatactca ctagatgagt agcctagttc tgaataaatg ctgtagtctt
    17581 ccctcctttt cttcctgcaa tatcgttcga ttaggatacg tgtgtatccc atatcagaaa
    17641 gattgttgat tgctttagcg attagttcta aatcctgctg agctgacact ctacgcacga
    17701 ccatgctttc tacttgctta cttgtctgac cacttgatga ccttggttca agtgagtagg
    17761 atattgttat tttgggggcg tattcttctc cagctatccg tctcagacga ctgtattttt
    17821 ttagtacttt gatagcttcc tttctggttt tcttttcgtc gatgatatcc aataactcta
    17881 tttgcacacg aactcctcct catgatataa tagttatgcg aaaccatacc atgaaggtca
    17941 gccgtgtgct ggcttttttt catgccctac tcccgagaat aatatcagca ggaaaagcaa
    18001 agtaagtaca gatatcttct acattataaa tatccggtac actttcctcc ttctcccatt
    18061 gagcaattag gtagcgacta tagcctagtt tagctgctaa cttttcttgt gacagcttcc
    18121 tttccttacg tttttgcttt agcaagaaag caaacctact tgcttgtctt ggatttaatt
    18181 tatcattcat catccacctc gatctttacg acagctctac catttggatt tcttctttgc
    18241 gtggatgcaa aagtgtaata ctttaacatc ctttcagcaa tacctgtttc tttactgatt
    18301 tccgcaagag ttcccaatgt tatgaacacg tcgccttgat ataacgcgta ttcactcatg
    18361 ttccatctcc tcaatcagcc aatcgatgat ttcctcgtct tcagtccacg catacccact
    18421 tagcaatccc tttagatata tggaaggcat tccgcctatg aatgtgccac cgtattcttt
    18481 ttctaaatat acttcatgga gacatcctct tgtacattta acgatgtcac cgatgaatac
    18541 ctccttgccg ttcttgtctc tgagtcctgt tgattgtcct aatgttgctg gatttacagg
    18601 acaccaagaa cctatagtaa tgtattgttc attggcttct accacttcgt tgataataaa
    18661 tgctcttcct ctatcttcaa ttaaatgtcc gtattgccat tctcctttgc ttttttcgtc
    18721 aatggataac cctctaaatt ttggtatcat gctaacactc cttaaataaa caaactagct
    18781 aaccatatca aaaatgcaca tgtaatgatt tttgaaatac tgctctttac cgcatacgaa
    18841 taatcctctt cagattcttt tttgctagat aacacaggcc agatgaaaga tagtagtgca
    18901 tccatcccta atgcttgcca gactgtaatt ttaccaactg gaacaattgt tgtgataatc
    18961 tcattccatc catactgaac tacaaatggc gatacaacga ttacaaatac cgccccaata
    19021 atgattccta gtcttttcat tttataaatc ctcctctttg acgaaagcac catcaatcca
    19081 acgaccctac cgttttctaa atcacggtca ataaaccatt gtttgacttt ctctattgtg
    19141 ttcatgataa ctcctttgct attgctgcta tgacattaac tgtcacgcta tttcctgctt
    19201 gtttatataa ttgactgtta gagttgacct cctgcgcctt atcaaaagcc caatcaggaa
    19261 aaccttgtaa cctccagcat tctctaggtg ttagctttct gattcgaaag ccatctgata
    19321 aatgattgtt ttcgtgatag ctattgctag ttaaagtagg agcgatgtca tgttctccac
    19381 ctttattata accatgccca cgttgaataa ttttaggctc aagtcctcca ccttgatagg
    19441 ctctgatagt tggtgcgatg ccgtctgttt cgtaaaccac cccacattga ttaaaattgg
    19501 gttgcaatac cccaaattgt tttatagtat tgctttttat agctatcttt tgcccctctc
    19561 ccttgtttgt tgttagcgtg ggagctagac catcagcttg atagacttcc ccattcattc
    19621 cgttgccaga tgggtttata ttcccaattt tcatgactga ttggttacta gttgactgat
    19681 tttttccgct gagaggaaaa aatcttctgg tacgttctct tctaagatgt ccgataatga
    19741 acactcgttc ccgattttgg gggactccga aattcttgct gttaagcact tgccattcca
    19801 cgttgtaccc cagttcatcc aaggttgaga taatggtctc gaatgtaact ccattttcgt
    19861 gattgagcaa tcctttaaca ttctcaagga atagatattt aggtctgaga atagatgcga
    19921 acctagcaat ttcaaagaac aaagttcctc gtgtatcttc aaaacctcgt ctgtttcctg
    19981 caattgagaa agcttggcac ggaaatcctc cacagataat gtccacactt ccgattcctc
    20041 gaatagattc atctgatact gctgtgatgt catgtaattc tatttctcct ttcgtattgt
    20101 gtatcgcttt atagctttct ctagcaaact tgtcaatttc acaaaagcca atacatttat
    20161 ggccggcaga ctccattcct aaacgaaaac cgccaattcc tgcgaataaa tccaagaatt
    20221 tcacaacatc acctcatacc caactttcac tttctcatac acgttcttca aaataactat
    20281 gaaatttact taaattgaca atagcgacct cttcaacaga atgctttccg atgtcaaagt
    20341 ctggatcatt cttcccaaac tctttttcta tagctttttc agccagaaaa ggcaaatcga
    20401 atatacttgc cccatttctt aaagcgagcg cttgaccgta tttgttcact attcgatacc
    20461 ctatatcaaa cggtctgatt tcccttggga cttttatgca tttactttga ttcttcattc
    20521 cttcttcaag tgtttgtgtc atcactccac ctcctcaatc tcaatccctg gacaatcaaa
    20581 cacccagccg aagtccgctt ctttgagttg tttgcgagta aattttgtag ctagtccgcc
    20641 catagagaag aatagtttct tatccatagc attataatat agcggttgtt ttgttgcttt
    20701 cgtcactact gtataccgct tctcttcctc gacctcgtag ccgaactggt gcatgttgac
    20761 gagggtttga ataggatttt ctctgctatt attaatccaa ttattaaact ctctattttc
    20821 tgatttttta gcctcatccc tgaaagcaat ccaatcccaa acattaaatt caaaagaatc
    20881 cttattctct tcataccaat ccgccacaaa ctgcggtact acgactttaa ttttggattt
    20941 atcaacgatg tcgtctgtaa tataaatatt attgttgggt acattgagag tttgcccgta
    21001 ttccaatcta acaacatttt caacgcactt gttctcatcc acatcaaaac cgactatttt
    21061 ccctttcaag agaacttcat cccctataaa aaagttaaag cgtggtgttt caattagatc
    21121 tttattcatt ttccacctcc tcaatctcaa ttccttcaca atcaaacacc cagccgaagt
    21181 ttgcgtcttc tagttcttta cgggtgtggg aatatataac atcgtctaaa ctaaagcttt
    21241 ttgtaaagaa atacctttta aaaagttctc cataaaccaa catattttct ttaatattcc
    21301 ctttaatctt aacaaaatac cgcttctctt cctcgacctc gtagccgtca agccatgctc
    21361 tagctactaa atcaaatggt ctttcttgca taaaccattt tctaacttca tcgttcgtga
    21421 aatcaaattc gaataattct accacgtctt tacaagcttt tctagcttcc tcaatccatt
    21481 cagccacaaa ccgcggaact ttgacttttt cacgttcaac cataccctca attttacctt
    21541 gctcgtagcc ctctcgccat tttgcacggc taaaatcctg ttcaaattcg ctcatgatag
    21601 cctttaacca aacctctcta tcatgcaatg gcaattctcg caatcgtgct agtatgttct
    21661 ttacgtagcg tggagcttca tctgcgtaac ctatttcgga ttcgtctagt tgtttcaagt
    21721 cttctagaaa aatttgacga gctagctctg ctccttcagc atcccataca ccctcaagtt
    21781 ttttatactt ctcaattaat cgctgtacat tcatcttagt ttcctctata aatcaaataa
    21841 actgcaataa ctacctgagc catgcttggc gaatagccaa cccaatcatc aaactcctta
    21901 gattttggca accaatcctt agtagctccc aattcatagt ctgtaggctt ttcatcagcg
    21961 aagatgcatt ccatcgctcc cataaacgtc ataccatctt ctgccatttc ccaaaaatag
    22021 tccgcccggt ctttcaccgc ttgtggtaaa tcttgcttgg gaggttgcgg cttcccgtct
    22081 tctaccgtcc agttgtatac ttcattaact ttttgcttta actcttccat catcttccaa
    22141 cttcttcact ttccgtctta attctttatt ctttttcttc aacaaatcgc gctccagcgc
    22201 tctaatccgt ctcttgcgtg catcacacgg cttcgaatac tcgattatct tctcttcgtt
    22261 ttgctcgatt gtgcgtttca gtccatcaat gactgttcgt ttatcataat tcatcttcta
    22321 aaaatctttc aatagcttct ctgtaggaga cttccaccag accgtctaag tcgttcaggg
    22381 cttcaatata gtctggacgc ccttgtccat actgctcttt caaaaattca acaaagagat
    22441 gaatttcctg ataggttact ccaaccatat ttcttacctc ccactaaaaa tgtaacgtta
    22501 ttgatcatct ttcttttcct ttcttgctgc acgttccccg actaaatagc cgagaaataa
    22561 ccacagaata gccattccaa attctttaat aagttcaatc atttttttct cctcctgaaa
    22621 aagtcgctaa atagtaacaa tccttcgaac cgtagtcaaa ccgtgtcgtc cgctgaccaa
    22681 tgtgcttctg aaatcttgga tgagtgatag ccgagaaaac ccactgatga tcttccatct
    22741 gttcaatgag atcatcgaca ttgtcaaacg ttccaaggta aaacttgcag tgcccgttgt
    22801 agacgaagta aagctctaac atcactccac ctcaacggga taaaaattcc caaaggaacc
    22861 cctcaaagcc ttaccaacct gtacggctgc cccacgagaa acaaaccgca tggctttctt
    22921 ctcctctgaa catgaaatgt ccaagccagt cacaccaata actacggacc tcagaaacgg
    22981 cttatcctct cttgtcccat gtcttaaaat aaacatcagc cacctccatt ctaaaaatat
    23041 tgcttccgct tgtttgtcaa gtcgttgaaa accattaaat ggtctttatc cacacccttc
    23101 atcagtctgg acataaaggg tctgccatat cttttctgaa tatcagcaga agtcaaattg
    23161 gtggtaatga ttgtatttga acgcttattc aggatattgt agagaatagt aaacgaccat
    23221 tcgctatcct tttccattcc caaatcatcc aaaaccaaga acttagcact ggcaatttta
    23281 ttgaccagaa actcctcctg actaaaatca gctttaatct tcatcaacaa gtccgtcacg
    23341 ttgatgaaga tagcaatctc tttcgtgtac tcagatagag ccttaaccat cgcaaaggcc
    23401 aaatggctct tacctgttcc agcttctcct tgtaacacga tgttgttcct agcaccctca
    23461 gaccactcac gacaaatcct ctttgcaaaa actagctttt ctgtttcttt ttcagttggt
    23521 gtttcaaaat tgtccaaagt cgcatttttc aaaacctcat cataaagaga aaacttctca
    23581 agatagtatt tcctctctcg ctcattctca gcgtcggcca attcattcac tcttgcttga
    23641 ttttcctcat gaatccgctc agattcacac atgcggcata caacactctc agtccgcaat
    23701 atttttatca aaggaatatt atgcttgtcg caaagctctt tctgttgttc tgtattcctg
    23761 tgataagata aggcaatttc atcaaacaca ttgtctacca tgacagacga cctccgcatt
    23821 catgccagct agccatttca gacaagcaag caaccacttg atgaattggc tggttggcta
    23881 aaagagtttt cttctcgtag cttaacggat aatagtcaat ctcgaattgc tcaattagtt
    23941 ctaaaatccc cattcgtccc ttacctcctg ttccgatgtt ttatcgtttt gttgtcctgg
    24001 acgactgtaa ttctttccct ctttatattt ttggtcattc tcatctacct gttcaatcga
    24061 tgtaaaacct ttctttttcc aattctcaag aatgcctctt agatacttaa aactaggttg
    24121 atgaatctcc gaagttatct caattgcacg gtttaacata tcaaaattca ttccatcaat
    24181 tcctacatat tcaagcaact gttgatgttg tttatcgttg attcgaatac cactatgttt
    24241 caaattttca gagaggctgg aactaatcat caccttatta tttttatctt tctctatctc
    24301 tttatctata tctatatctc cgttgcaagt tgttgcgata gtgttgcaat gcaacttttg
    24361 taattctctg tgcttacgac ttctacgagt actcgctgtt tcactcccaa ccatctcagg
    24421 aacctgttct aagaaataat cacggtcaga gtttctagtc agcaatcctt tgctttctaa
    24481 aaaaatcaat gtaattttaa tatcttcaac attttcgtca atgacaagag cgatttcttc
    24541 ggctagattg tcagcaagtc catcatagta aatatgccct ccgtcttcca agctaattaa
    24601 catcattttg agataaatga tggtatgtgt atctccgcca gcaatcttac gaagtagttt
    24661 catctccttt gacttaaaga agtcctgagc aagctggatc cagaaatacc gcttgttttt
    24721 taacgccata atctcccccc cacttcctac ggttagcgcg gtacttcatc cgcatatcct
    24781 catagatgta cctgccttcc agctccattt tttcaatctt tagcagctta tttttaagct
    24841 ccacatcacg atagtcctta gctagttttt catagtctgt taggtattct ttgactagta
    24901 atagattttt ataatcgttt tcccatatcg taataaaatg tcttgaagtt gattcccttc
    24961 cttccagtcc tttaacaatc ataatcaggt tatccagcga ttcaatcaat tcttccattt
    25021 cctgacctcc tcattacaaa aatctgattg cagactgttt aggttctggc aaagctaacg
    25081 gctcaggacg caagcctaca ggcggttcat tgtcgtaggt aaagcccttg aacggacgac
    25141 gaatattctt gcggatttct tgacgttcag cctctctacc acgttcgtaa gcatggttat
    25201 agcctcgaat aatcatagac gcaaattctt gctcttctcg tctttcttct tccttgcgtt
    25261 gttcctgcaa tttgatatga cggcaagccc ctgcaaatcc aagcagtaag gctccaaccc
    25321 ccatcagctg gtctaaaatc ggtggttcaa acatttttat ctccttatcc tctttttgtg
    25381 ctataatata gtcaaataat tttgctaaga ccttgtccag aagcctttta gtaaagttat
    25441 tatatttgat tagagagcca ttctttgatg gctctttttg accatttctt accaggtaat
    25501 tcctttggaa atccctttaa gtaacgataa ttatctgaaa atgtggcata cttaattcct
    25561 agaaattcgc aggtagtgtt cacatccatc aactctggat agtgatcact atctttttct
    25621 atttcgacta gccttgtgat tgtgtccttg ataatagatt taatccattc agatagtgaa
    25681 agtagaacat tgtccatctt cttcccctcc tacccttcgt caaatgagtt caatttcatg
    25741 attttcatct tggtattagt gcttggctcc cacgtcatcc aataagcaag agcggcatcc
    25801 gcatgcttct tgggtagtaa gtcatagcga ctgatattaa aatgatcctt gaaatcaatc
    25861 tcagcttgtc taaataccga ctgagcgaaa atcttatcag cataagcagg actatcaata
    25921 ccacctaagc aagccacgac acgagctttg cgcttcttca ggagcgactg agcatagctt
    25981 ggatgaatcg gttgctcgct cttgaggtag tcgatatctt ccagcatgct agtctgttgc
    26041 tcccgcaatt tcttctggcc agtaaaaaga gcgataaagg catcctcgtc caagtcctca
    26101 cggataaaac caccctgctt gcgaatagct ggcaaaacct ctgatgtcac ccaacgcttg
    26161 aactccttag cttgaggcaa cttgcttgat aagataagag agtagagacc tgattcgttg
    26221 atgactgtct gatttctcat ctgacctgcc gtcgcgattt gcgacgttag cttatcatct
    26281 tcatcaacgt gttttgccag agcatctcta gaatttacat atccaagaat ctctgctata
    26341 tctttcccga caaaccacgg ttcgtcatca aacatcactg tacggacttc ctgcccatga
    26401 aagttaaaaa tttcgttcat agtattcctt tctttaattt gtcgcactta tgcgactgtt
    26461 tcgctaaaaa aaatagataa agcttcgtct tttgaaagac cgagggaaga aacaatcaag
    26521 tttacttctt gtatagagaa actaccattt tgtttcattt ttctatagaa cgtactctta
    26581 tcaatcccaa tatcttttgc taaagcctct tgagtagtat tgcgttcgat aatttttcct
    26641 tttaatttcg atacatttac catatctgct ccttttcatt tgtcgcattt acgcaactta
    26701 ttgttttaag tataactgat aaaaaatgaa atgtcaataa gaaaatcgca tttttgaaac
    26761 tttttatatt gcatttttgc gactaatgtt gtaaaattat tgtgtaatat ataataaggg
    26821 gtaaaaaaat gaatgtcgga gaaagaataa aacaacgtcg aaaagcgttg aaaatgtctg
    26881 cggacgagct tgcagaaagt gtaggtgtct ctcgttctac tatttttagg tacgaaaaag
    26941 gagatattga aaaagttgga cctgaagtat taaaaaaaat cgctgacaaa ttaaatgtat
    27001 cacctggaga cttgatggga tgggaagaca atcaacaaga attgaaaatc ccaacctccc
    27061 cgttggttca caaaattact gaaaaggttg tcaaactatc aactccgaga aaacaaaagg
    27121 ttcttaacta cgctaacgaa caattgaaag agcaaaataa taaagtaatc acaattgagg
    27181 aaaagctttt tgaatatcgt gtttttgaaa aactttcagc tggtactgga ttctcatact
    27241 tcaacgatgg gaactatgac actgtttttt acgacaaaga cctagaccac gattttgctt
    27301 cttgggtttt cggagattcc atggagccta agtacatgaa tggagaggtc gttctcatca
    27361 aagaaacagg ttttgactac gatggtgcca tttatgcagt tgactgggat ggtcaaactt
    27421 atattaaaaa agtctataaa gaaaaagacg gtcttagact cgtctctatc aataacaaat
    27481 ataaagataa attcgcacca tttgaagaag atccaaggat tattgggaaa atagtcggaa
    27541 acttcatgcc aattgaaaat taaaaggaga aagttatgaa aataggaatg agaaaaccaa
    27601 gtctgaccag aagtttaaaa gctagaacta ctagtaaatg gaagagacag gcaaaaaaag
    27661 cccttatccc tggctatggt aagaaaggga tgggatgggt taaaaatcca aagaaagcta
    27721 tgtataacaa ggtttatcat aagacaacct ttggactttc ggatttgttt aaatcatcta
    27781 aaaagcgaaa aaagaaagta gtcaacaaca aacagcaatc tattcttgcc tcgaacggca
    27841 aaaagcaaca cactccaaaa gaatataaag aagctggact tgtctttatg gttttaggtg
    27901 ctatattcct atttttattt ccacctctcg gcttcttctt gtttattact ggttttataa
    27961 cttacattat tggtcgttta actgcaaagc gagagaaaaa gcagaaagtt gaaaattaca
    28021 gtccacagat tgatacaatt gttttccgag ataatttttt attaatggga acaaattatc
    28081 atcaagaaga agctgagatt gcagctgatt ttctttccaa gggtgtccat tattttggga
    28141 aagataataa gagtttgaaa tcttatatgc ttgaaacata taaacctgtt tacaaataca
    28201 ataaattgaa aacagtagac gttcaactat taccagaacc ttcaaatccg catgataaaa
    28261 atgctgtcaa agttttagtg aataatatct ttgttggata cttaccagct gtgatcgcat
    28321 cacaaatttc atcctacatt tctaatccaa attacagata tgatgcaatc cttacaggta
    28381 gaggaggacc atataaaacc ctaaatatcg aaactgagag agtcgtttct cgtaaaagtg
    28441 acttaactta ctatttagat ttaacagtat ggcgtcttgc taaaaaataa aaaaaaacca
    28501 caatctccct cgccaaagtt tgattgtgaa gctcaccctt ataaaaaatc agccattaaa
    28561 aaggcctctt ttctataccc tattttacac catgaaaggg gtgatgtcaa tattctcaat
    28621 gtttagacct tgtccagaag ctgataaaca aggagaatac aatgaaatat aataaaacaa
    28681 aatacccaaa tatctattac tatgaaactg ccaaaggcaa gcgatactat gtcagacgtt
    28741 cttttttctt ccgaggtaaa aaaagagaaa aaagtaaaag tggtctcaca acccttccac
    28801 aagctcgtgc agccttagta gagcttgagc aacaaatcca agaacaagaa ttaggtatca
    28861 atacgaatct gacacttgat caatattggg atatttattc tgaaaagaga ttgtcaacag
    28921 ggcgctggaa tgacacttcc tactacctca atgataatct ctacaagaac catatcaagg
    28981 caaagtttgg ttctaccctg cttaaaaatt tggatagaaa tgagtatgaa ctctttatcg
    29041 ctgaaaagtt gcagaaccat accagataca ctgttcaaac cctcaattcc agcttcatgg
    29101 cattgctgaa tgatgccgtc aaaaatggaa atctgctctc aaatcgcttg aaaggtgttt
    29161 tcatcggcca gagtgatatc cctgctgcaa acaagaaagt gactctcaaa gagttcaaga
    29221 cttggatagc aaaggcagaa gagattatgc caaaacaatt ctacgctctg acctatctga
    29281 caatttttgg attgagaaga ggagaagtct ttggattgcg tccaatggac atcactcaga
    29341 acgacagcgg acgggctata ctgcatctta gagacagtcg aagcaaccag accttaaaag
    29401 ggaaaggagg gcttaaaacg aaggattcag agcgatatgt ctgccttgat gatatcggaa
    29461 cagacctgat ctattatctg atagctgaag cttctaagat taagcgaaag ttaggaatta
    29521 tcaaggaaca gcacaaggat tatataacta tcaacgagaa aggtggtctc atcaatccaa
    29581 accagctaaa tagaaacttc aatctagtga atgaagcaac aggattgcat gtaacacctc
    29641 acatgatgcg ccacttcttc acgactcaaa gcattattgc aggggttccg cttgaacaat
    29701 taagccaggc gctgggccat acaaaagtct atatgaccga tcgttacaat caagtagagg
    29761 acgaacttgc tgaagcgaca acagacctat ttcttagtca tattcgctaa aaaagtcccc
    29821 gccaattccc cgaccaaaat ccgaaaaata ccgaaaaata tcgaaaaatt atttttagaa
    29881 tagtccccaa aagcctgaaa taaagctaaa aaactccacc tgattgggtg gagttaaggg
    29941 agattattat gaaaaagaaa agtttaggat atttgttaca acaagttagg aggtcttctt
    30001 gtaaccgtct atagtatacc cgacctatct taaacaaatc ttaaaaatct cttaggacca
    30061 aacactttct aaaatatttg tttgttcacg accaggacct actgagaaag tagaaatacg
    30121 aacgccaacc aattcactca cacgacgaac atagttacgc gcattctcag gaagatcttc
    30181 caaattgcga actccggtaa tatcttctga ccaacctggt aactcttcat agataggctt
    30241 gcaacgtttc aattgctcaa gactagctgg atagtagtca atacgttgac cgtcaagatc
    30301 ataggccaca cagattttca cagtatccaa accgctcaaa acatcaatag agttcaaaga
    30361 aaggttagta ataccagaaa cacgacggct atgacgcatc acaactgagt caaaccaacc
    30421 tacacgacgt ggacgaccag ttgttgtacc atactcatga cccacttcac ggatacgttc
    30481 tcccacttca tcaaacaact cagttgggaa aggaccatct cctacacgac tcgtataagc
    30541 tttacataca cctacaacct tgtcaatctt gcttggaccg acaccagaac caattgtcac
    30601 accaccagct acagggtttg atgacgtaac aaatggataa gtaccttggt cgatatctag
    30661 cataacacct tgtgcacctt caaaaagcac acgtttgcca ttatcaagcg catcattcaa
    30721 gataacagat gtatctatca cgtatttctt gatttgttga ccatattcgt aatattcttc
    30781 aaaaatatca tcgaaaacaa tcgctttact gtcatacaat ttttcaaaaa gacgattctt
    30841 ttcagcaagg ttacgttcta aacgctcacg gaaaatatct ttatctaaaa gatctgcaat
    30901 acgaattcca acacgagcag ccttgtccat ataagctgga ccaattccct taattgtcgt
    30961 accaatctta ttgtcgccct tagcttcttc ttgcaagcga tccaactcga tatgataagg
    31021 caaaataaca tgcgcacgat cagaaatacg caagttatca gttgttacac cttcctcatg
    31081 aagatagctc aactctttta caagagattt aggatttaca accataccat tcccaatgac
    31141 agatattttt tcagggaaga aaatcccaga tggaatcaag tgcaacttaa atttcttacc
    31201 gtcaatcaca atcgtgtgac cagcattatc accaccttgg taacgtgcaa tcacttctgc
    31261 attcgctgaa aggaagtctg taatcttccc tttaccttca tcaccccatt gggtacctac
    31321 aacaacaact gaagtcataa ttttgtctga gccctcaggc tcttcctttc tcacatacat
    31381 ggcaggactc tcacctgcaa ttatatctta caatttatta taataaaaaa tcgccttttt
    31441 atcaagaaga aacaatagaa agatttgcta tttccaacta ttaaaaaatg atttagaaaa
    31501 attactagct atttactatt atctttccat aaaagagtaa attagttcgg aaatttacta
    31561 aaattacctc aacaagaaat aaaaccccga ttcattacca atttttcaag atacaaacga
    31621 taagcaacac gataatggta aacaataaaa tccttacgac aaccaatgcc atatctcact
    31681 aaataataaa ttaaaaattt aaaatgaaca tgttcccagt caaaattatc accaaatgta
    31741 ggaccatact cttcttcaat actatcatag aaattagcca tctgctcata aattttttgt
    31801 aacataatca aatactcctt ttctttttta taaacttatt ctaacaaaaa attttacaca
    31861 ttcactatca attcctgaat tgttaaaata ccagcctcaa caagataaaa ataggaaaag
    31921 ttgacaaaat agaaacaaat ttgctaccta aatttcaaac aattaaagtt ctaaaaagac
    31981 cgccttaaaa cttttgggta aatcctatta gaactataat atttttatat aggtattatg
    32041 gttctgattt tctagtataa aaaaattcaa actagaattc ttcttagaaa aggccgtttt
    32101 aagtgctatc attgctcaaa aatggagctc gctgagactt ctatcgtcaa gaagaatcat
    32161 caaattcctt gtatcatcaa ccaaaagatt gctcagaagc taattgaaaa gacttctatg
    32221 accgacattg atcatcagtt gtctatttca acttcaactg tcattcgcaa gatcaatgat
    32281 tttcactttg agcatgattt ttcgcgtctt cctgagatta tgtcctagta cgttgaaaca
    32341 gtccagggag tgactatttc aatcgggaga tggagatgag ctttattgct caggactttg
    32401 ataagctcaa tatcataact gttcttgaga gcagaacaca agccatcatc cgaaatccca
    32461 tggatacaag gctatcaagc gctactggaa actcattcaa caggatagtc gtaaactgag
    32521 tgataaacat ttttatcgtc ctacttttcg tatgcactta accaataaag agattttaaa
    32581 caagcttttg agttattcgg aagacttgaa acaccactat caactctatc agctcttgct
    32641 ttttcacttc cagaataagg aaccagagaa atttttcgga cttattgagg acaatcttaa
    32701 gcaggttcat cctatttttc agactgtctt taaaaccttc ctcaaagata aagaaaagat
    32761 tgtcaacgcc cttcaattac cttattccaa cgccaaactg gaagccacca ataatctcat
    32821 caaacttatc aagcacaatg cctttggttt taggaacttt gaaaacttca aaaaagaaag
    32881 gacgaaattt gtcctttcta aatcttcgct ttcttcaacc cactacagtt gacaaagaac
    32941 cgaaaaatgt ctcgcctcta atatagtcaa ttgaaacaag aacaagacaa aagagcctcg
    33001 taaaaggtat tgcaacttgg taataccttt ttgaggtgct ttttgatatg agcccatgtt
    33061 ttcttaatag gattgtactc aggtgagtag ggaggaagag gtaaaagttc atgcccaaac
    33121 tcctcgcata aaagttctag cttacccatt ctatggaatc ttgcattgtc cataatatag
    33181 tagattgaaa ctagaatagt acacctctac ttctaaaaca ttgttagaat tcgattttac
    33241 tgtcctgatc gatttgtcct attcttattt cattttacta taacacgaaa tagattatta
    33301 ttacataaca aaaaagaggt ctaaacctct taactaaatt actccgccag taggactcga
    33361 acctacgaca tcatgattaa cagtcatgcg ctactaccaa ctgagctatg gcggatta
//
LOCUS       DAVLHC010000019        33214 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.019, whole genome shotgun sequence.
ACCESSION   DAVLHC010000019 DAVLHC010000000
VERSION     DAVLHC010000019.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 33214)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 33214)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..33214
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.019"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            388..2541
                     /locus_tag="VXE25_001040"
     CDS             388..2541
                     /locus_tag="VXE25_001040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000668284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide cleavage/export ABC transporter"
                     /protein_id="HEV0771516.1"
                     /translation="MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKT
                     TMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVTG
                     QDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPYKEQKNGLLSFIPI
                     LVKQRGLIANIVLATLLVTGINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYIL
                     QQILSYAQEYLLLVLGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSII
                     DALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNR
                     DTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQK
                     ALKKVAHLLLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQT
                     AQVANNRLNEVYLVASEFEEKKTVEDLSLMKGDMTFKQVHYKYGYGRDVLSDINLTVP
                     QGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYINYLPQQ
                     PYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISG
                     GQRQRIALARALLTDAPVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAE
                     RTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS"
     gene            2554..3903
                     /locus_tag="VXE25_001041"
     CDS             2554..3903
                     /locus_tag="VXE25_001041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HlyD family secretion protein"
                     /protein_id="HEV0771517.1"
                     /translation="MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKE
                     MSLSTRATIEPSRILANIQSTSNNRILVNHLEENKLVKKGDLLVQYQEGAEGVQAESY
                     ASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
                     ETIASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAMETGASLASQNLAYSLYQSYK
                     SQGEENPQTKVQAVAQVEAQISQLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQ
                     HLAKVGQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLHLNPETSDSSMVAEG
                     ALLAQLYPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSID
                     ATATKTEKGNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE"
     gene            4073..4780
                     /locus_tag="VXE25_001042"
     CDS             4073..4780
                     /locus_tag="VXE25_001042"
                     /EC_number="6.3.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000043309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="HEV0771518.1"
                     /translation="MSKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAG
                     KGVLNNQISSFIFEKLNAAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSK
                     RFGVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIAGDQQIAYLKEETRRINEL
                     LKVWFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLG
                     ELTDVYEIVWEKLQELK"
     gene            4982..8707
                     /locus_tag="VXE25_001043"
     CDS             4982..8707
                     /locus_tag="VXE25_001043"
                     /EC_number="6.3.5.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000361233.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylformylglycinamidine synthase"
                     /protein_id="HEV0771519.1"
                     /translation="MDKRIFVEKKADFQVKSESLVREFQHNLGLSSLKSIRIVQVYDV
                     FDLAEDLFAPAEKHIFSEQGTDHVLDEVSVQADLANYAFFAIESLPGQFDQRAASSQE
                     ALLLLGSSSDVTVNTAQLYLVNKDIDATELEAVKNYLLNPVDSRFKDITTGIAKQEFS
                     ESDKTIPKLTFFESYTAEDFARYKAEQGMAMEVDDLLFIQDYFKSIGRVPTETELKVL
                     DTYWSDHCRHTTFETELKHIDFSASKFQKQLQSTYDKYIAMREELGRSEKPQTLMDMA
                     TIFGRYERANGRLDDMEVSDEINACSVEIEVDVDGVKEPWLLMFKNETHNHPTEIEPF
                     GGAATCIGGAIRDPLSGRSYVYQAMRISGAGDITAPISETRAGKLPQQVISKTAAHGY
                     SSYGNQIGLATTYVREYFHPGFVAKRMELGAVVGAAPKGNVVREKPEAGDVIILLGGK
                     TGRDGVGGATGSSKVQTVESVETAGAEVQKGNAIEERKIQRLFRNGNVTRLIKKSNDF
                     GAGGVCVAIGELADGLEIDLNKVPLKYQGLNGTEIAISESQERMAVVVRPEDVDTFVA
                     ECNKENIDAVVVATVTEKPNLVMHWNGETIVDLERRFLDTNGVRVVVDAKVVDKDVKL
                     PEERQTSAETLESDTLTVLSDLNHASQKGLQTIFDCSVGRSTVNHPLGGRYQLTPTEA
                     SVQKLPVQHGVTHTASVIAQGFNPYVAEWSPYHGAAYAVIEATARLVAAGANWSKARF
                     SYQEYFERMDKQAERFGQPVAALLGSIEAQIQLGLPSIGGKDSMSGTFEELTVPPTLV
                     AFGVTTADSRKVLSPEFKAVGENIYYIPGQALSAEIDFDLIKKNFAQFEASQADHKVT
                     SASAVKYGGVVESLALATFGNYIGAEVTLPELKTALTAQLGGFVFTSPEEIAGVEKIG
                     QTKADFTLTVNGVKLDGHKLDSAFQGTLEEVYPTEFTQAKELEEVPAVASDVVIKAKE
                     KVEKPVVYIPVFPGTNSEYDSAKAFEKEGAEVNLVPFVTLNEEAIVKSVETMVDNIDK
                     TNILFFAGGFSAADEPDGSAKFIVNILLNEKVRVAIDSFIARGGLIIGICNGFQALVK
                     SGLLPYGNFEDANSTSPTLFYNDANQHVAKMVETRIANTNSPWLAGVQVGDIHAIPVS
                     HGEGKFVVTAEEFAELRDNGQIFSQYVDFNGKPSMDSKYNPNGSVHAIEGITSKNGQI
                     IGKMGHSERYEDGLFQNIPGNKDQHLFASAVKHFTGK"
     gene            8800..10242
                     /locus_tag="VXE25_001044"
     CDS             8800..10242
                     /locus_tag="VXE25_001044"
                     /EC_number="2.4.2.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000220605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidophosphoribosyltransferase"
                     /protein_id="HEV0771520.1"
                     /translation="MTYEVKSLNEECGVFGIWGHPDAAKLTYFGLHSLQHRGQEGAGI
                     LSNDQGQLKRHRDMGLLSEVFRNPANLDKLTGAGAIGHVRYATAGEASVDNIQPFLFR
                     FHDMQFGLAHNGNLTNAASLKKELEQRGAIFSATSDSEILAHLIRRSHNPSLMGKIKE
                     ALSLVKGGFAYILLFEDKLIAALDPNGFRPLSIGKMANGAVVVSSETCAFEVIGAEWI
                     RDLKPGEIVIIDDEGIQYDSYTDDTQLAICSMEYIYFARPDSNIHGVNVHTARKRMGA
                     QLAREFKHEADIVVGVPNSSLSAAMGFAEESGLPNEMGLIKNQYTQRTFIQPTQELRE
                     QGVRMKLSAVSGVVKGKRVVMVDDSIVRGTTSRRIVQLLKEAGATEVHVAIGSPALAY
                     PCFYGIDIQTRQELIAANHTVEETRQIIGADSLTYLSIDGLIESIGIETDAPNGGLCV
                     AYFDGDYPTPLYDYEEDYRRSLEEKTSFYK"
     gene            10279..11301
                     /locus_tag="VXE25_001045"
     CDS             10279..11301
                     /locus_tag="VXE25_001045"
                     /EC_number="6.3.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009729529.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylformylglycinamidine cyclo-ligase"
                     /protein_id="HEV0771521.1"
                     /translation="MTNKNAYAQSGVDVEAGYEVVERIKKHVARTERAGVMGALGGFG
                     GMFDLSKTGVKEPVLISGTDGVGTKLMLAIKYDKHDTIGQDCVAMCVNDIIAAGAEPL
                     YFLDYVATGKNEPAKLEQVVAGVAEGCVQAGAALIGGETAEMPGMYGEDDYDLAGFAV
                     GVAEKSQIIDGSKVVEGDVLLGFASSGIHSNGYSLVRRVFADYTGEEVLPELEGKKLK
                     EVLLEPTRIYVKAVLPLIKEELVNGIAHITGGGFIENVPRMFADDLAAEIDESKVPVL
                     PIFKALEKYGQIKHEEMFEIFNMGVGLMLAVSPENVERVKELLDEAVYEIGRIVKKEN
                     ESVIIK"
     gene            11298..11843
                     /gene="purN"
                     /locus_tag="VXE25_001046"
     CDS             11298..11843
                     /gene="purN"
                     /locus_tag="VXE25_001046"
                     /EC_number="2.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844573.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylglycinamide formyltransferase"
                     /protein_id="HEV0771522.1"
                     /translation="MKKIAVFASGNGSNFQVIAEEFPVEFVFSDHRDAYVLERAKQLG
                     VLSYAFELKEFESKTDYEAALVELLEEHQIDLVCLAGYMKIVGPTLLSAYEGRIVNIH
                     PAYLPEFPGAHGIEDAWNAGVGQSGVTIHWVDSGVDTGQVIKQVRVPRLADDTIDRFE
                     ARIHEAEYRLYPEVVKALFTD"
     gene            11927..12436
                     /locus_tag="VXE25_001047"
     CDS             11927..12436
                     /locus_tag="VXE25_001047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000894002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanZ family protein"
                     /protein_id="HEV0771523.1"
                     /translation="MLESKKTTRYVFYVYLMLLTWGILFKFETNPEFIAFFLAPRYIN
                     WIPFSEPLIVDGKIVFAEMLFNLISFIPLGVCFPLIKTNLSSLRIVGTGFLISLLFEC
                     LQYILAIGITDITDLTLNTLGVCVGLLIYQIFIRVFKSQTRKWINILGMLSLGFAYLV
                     LLLLHLIGV"
     gene            12461..14008
                     /gene="purH"
                     /locus_tag="VXE25_001048"
     CDS             12461..14008
                     /gene="purH"
                     /locus_tag="VXE25_001048"
                     /EC_number="2.1.2.3"
                     /EC_number="3.5.4.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006146083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     phosphoribosylaminoimidazolecarboxamide
                     formyltransferase/IMP cyclohydrolase"
                     /protein_id="HEV0771524.1"
                     /translation="MTKRVLISVSDKAGIVEFAQELKKLGWEIISTGGTKVALDNAGV
                     DTIAIDDVTGFPEMMDGRVKTLHPNIHGGLLARRDLDSHLEAAKDNKIELIDLVVVNL
                     YPFKETILKPDVTYADAVENIDIGGPSMLRSAAKNHASVTVVVDPADYAVVLDELAAN
                     GETSYETRQRLAAKVFRHTAAYDALIAEYFTAQVGESKPEKLTLTYDLKQPMRYGENP
                     QQDADFYQKALPTDYSIASAKQLNGKELSFNNIRDADAAIRIIRDFKDSPTVVALKHM
                     NPCGIGQADDIETAWDYAYESDPVSIFGGIVVLNREVDAATAEKMHGVFLEIIIAPSY
                     TDEALAILINKKKNLRILALPFNAQEASEVEAEYTGVVGGLLVQNQDVVKESPADWQV
                     VTKRQPTETEATALEFAWKAIKYVKSNGIIVTNDHMTLGVGPGQTNRVASVRLAIDQA
                     KDRLNGAVLASDAFFPFSDNVEEIAKAGIKAIIQPGGSVRDQESIEAANKYGLTMVFT
                     GVRHFRH"
     gene            14130..15392
                     /gene="purD"
                     /locus_tag="VXE25_001049"
     CDS             14130..15392
                     /gene="purD"
                     /locus_tag="VXE25_001049"
                     /EC_number="6.3.4.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000772208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylamine--glycine ligase"
                     /protein_id="HEV0771525.1"
                     /translation="MKLLVVGSGGREHAIAKKLLESKDVEKVFVAPGNDGMTLDGLEL
                     VNISISEHSKLIDFAKTNDVAWTFIGPDDALAAGIVDDFNQAGLKAFGPTRAAAELEW
                     SKDFAKEIMVKYGVSTAAYGTFSDFEEAKAYIEKHGAPIVVKADGLALGKGVVVAETV
                     EQAVEAAHEMLLDNKFGDSGARVVIEEFLEGEEFSLFAFVNGDKFYIMPTAQDHKRAY
                     DGDKGPNTGGMGAYAPVPHLPQSVVDTAVDTIVKPVLEGMIKEGRPYLGVIYAGLILT
                     ADGPKVIEFNSRFGDPETQIILPRLTSDFAQNITDILDSKEPNIMWTDKGVTLGVVVA
                     SKGYPLDYERGVELPAKTEGDVITYYAGAKFAENSRALLSNGGRVYMLVTTVATVKEA
                     QASIYQELSQQKIEGLFYRTDIGSKAIK"
     gene            15795..16283
                     /gene="purE"
                     /locus_tag="VXE25_001050"
     CDS             15795..16283
                     /gene="purE"
                     /locus_tag="VXE25_001050"
                     /EC_number="4.1.1.21"
                     /EC_number="5.4.99.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000805607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-(carboxyamino)imidazole ribonucleotide mutase"
                     /protein_id="HEV0771526.1"
                     /translation="MKPVISIIMGSKSDWATMQKTAEVLDRFGVAYEKKVVSAHRTPD
                     LMFKHAEEARSRGIKIIIAGAGGAAHLPGMVAAKTTLPIIGVPVKSRALSGVDSLYSI
                     VQMPGGVPVATMAIGEAGATNAAIFALRLLSVEDKSIADALANFAEEQGKIAEESSNE
                     LI"
     gene            16270..17361
                     /gene="purK"
                     /locus_tag="VXE25_001051"
     CDS             16270..17361
                     /gene="purK"
                     /locus_tag="VXE25_001051"
                     /EC_number="6.3.4.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000099033.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-(carboxyamino)imidazole ribonucleotide
                     synthase"
                     /protein_id="HEV0771527.1"
                     /translation="MSSSKTIGIIGGGQLGQMMAISAIYMGHKVIALDPAADCPASRV
                     AEIIVAPYNDVDALRQLADRCDVLTYEFENVDADGLDAVIKDGQLPQGTDLLRISQNR
                     IFEKDFLSNKAQVTVAPYKVVTSSLDLADIDLSKNYVLKTATGGYDGHGQKVIRSEAD
                     LEAAYALADSADCVLEEFVNFDLEISVIVSGNGKEVTFFPVQENIHRNNILSKTIVPA
                     RISESLVDKAKAMAVRIAEQLNLSGTLCVEMFATDDDVIVNEIAPRPHNSGHYSIEAC
                     DFSQFDTHILGVLGAPLPVIKLHAPAVMLNVLGQHVEAAEKYVTENSSAHLHMYGKIE
                     AKHNRKMGHVTLISNEPDSVDELGEGIDF"
     gene            17371..17598
                     /locus_tag="VXE25_001052"
     CDS             17371..17598
                     /locus_tag="VXE25_001052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006270103.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazole carboxylase"
                     /protein_id="HEV0771528.1"
                     /translation="MIQIIVNTFIEKDKTGAVVEVLYASADQDKVQAKYEELAAQYPE
                     NYLAIYDVPLDTDLNTLDHYPSVFIGKEEFE"
     gene            17661..18959
                     /gene="purB"
                     /locus_tag="VXE25_001053"
     CDS             17661..18959
                     /gene="purB"
                     /locus_tag="VXE25_001053"
                     /EC_number="4.3.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000572899.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylosuccinate lyase"
                     /protein_id="HEV0771529.1"
                     /translation="MINRYSRPEMANIWSEENKYRAWLEVEILSDEAWAELGEIPKED
                     VALIRKKADFDIDRILEIEQETRHDVVAFTRAVSETLGEERKWVHYGLTSTDVVDTAY
                     GYLYKQANDIIRRDLENFTNIIADKAKEHKFTIMMGRTHGVHAEPTTFGLKLATWYSE
                     MKRNIERFEHAAAGVEAGKISGAVGNFANIPPFVEEYVCDKLGIRAQEISTQVLPRDL
                     HAEYFAVLASIATSIERMATEIRGLQKSEQREVEEFFAKGQKGSSAMPHKRNPIGSEN
                     MTGLARVIRGHMITAYENVALWHERDISHSSAERIITPDTTILIDYMLNRFGNIVKNL
                     TVFPENMIRNMNSTFGLIFSQRAMLTLIEKGMTREQAYDLVQPKTAYSWDNQVDFKPL
                     LEADSEVTSRLTQEEIDEIFNPVYYTKRVDDIFERLGLGD"
     gene            complement(19014..22952)
                     /gene="strH"
                     /locus_tag="VXE25_001054"
     CDS             complement(19014..22952)
                     /gene="strH"
                     /locus_tag="VXE25_001054"
                     /EC_number="3.2.1.52"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000679939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-N-acetylhexosaminidase"
                     /protein_id="HEV0771530.1"
                     /translation="MKHEKQQRFSIRKYAVGAASVLIGFAFQAQTVAADGVTPTTTEN
                     QPTIHTVSDSPQSSENRTEETPKAELQPEAPKTVETETPATDKVASLPKTEEKPQEEV
                     SSTPSDKAEVVTPTSAEKETANKKAEEASPKKEEAKEVDSKESNTDKTDKDKPAKKDE
                     AKAEADKPETEAGKERAATVNEKLAKKKIVSIDAGRKYFSPEQLKEIIDKAKHYGYTD
                     LHLLVGNDGLRFMLDDMSITANGKTYASDDVKRAIEKGTNDYYNDPNGNHLTESQMTD
                     LINYAKDKGIGLIPTVNSPGHMDAILNAMKELGIQNPNFSYFGKESARTVNLDNEQAV
                     AFTKALIDKYAAYFAKKTEIFNIGLDEYANDATDAKGWSVLQADKYYPNEGYPVKGYE
                     KFIAYANDLARIVKSHGLKPMAFNDGIYYNSDTSFGSFDKDIIVSMWTGGWGGYDVAS
                     SKLLAEKGHQILNTNDAWYYVLGRNADGQGWYNLDQGLNGIKNTPITSVPKTEGADIP
                     IIGGMVAAWTDTPSARYSPSRLFKLMRHFANANAEYFAADYESAEQALNEVPKDLNRY
                     TAESVTAVKEAEKAIRSLDSNLSRAQQDTIDQAIAKLQETVNNLTLTPEAQKEEEAKR
                     EVEKLAKNKVISIDAGRKYFTLDQLKRIVDKASDLGYSDVHLLLGNDGLRFLLDDMTI
                     TANGKTYASDDVKKAIIEGTKAYYDDPNGTALTQAEVTELIEYAKSKDIGLIPAINSP
                     GHMDAMLVAMEKLGIKNPQAHFDKVSKTTMDLKNEEAMNFVKALIGKYMDFFAGKTKI
                     FNFGTDEYANDATSAQGWYYLKWYQLYGKFAEYANTLAAMAKERGLQPMAFNDGFYYE
                     DKDDVQFDKDVLISYWSKGWWGYNLASPQYLASKGYKFLNTNGDWYYVLGQKPEDGGG
                     FLKKAIENTGKTPFNQLASTKYPEVDLPTVGSMLSIWADRPSAEYKEEEIFELMTAFA
                     DHNKDYFRANYNALREELAKIPTNLEGYSKESLEALDAAKTALNYNLNRNKQAELDTL
                     VANLKAALQGLKPAATHSGSLDENEVAANVETRPELITRTEEIPFEVIKKENPNLPAG
                     QENIITAGVKGERTHYISVLTENGKTTETVLDSQVTKEVINQVVEVGAPVTHKGDESG
                     LAPTTEVKPRLDIQKEEIPFTTVTRENPLLLKGKTQVITKGVNGHRSNFYSVSTSADG
                     KEVKTLVNSVVAQEAVTQIVEVGTMVTHVGDENGQAAIAEEKPKLEIPSQPAPSTAPA
                     EESKALPQDPAPVVTEKKLPETGTHDSAGLVVAGLMSTLAAYGLTKRKED"
     gene            complement(23267..23983)
                     /locus_tag="VXE25_001055"
     CDS             complement(23267..23983)
                     /locus_tag="VXE25_001055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001007200.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HEV0771531.1"
                     /translation="MAIPKYQYIKDELKNKIISGQFSSGDKFYTEAELISMYDVSSIT
                     VVRALNDLAKDGYIVRQQGKGTFVSRARKHKLVEFSDIELFNAKDDKVTVLSIERGNK
                     LVYLEKLGLRGDQFYYKIERIRESNGVVYIYHTSYIPEQYINANYPNLEYYSSIYNRF
                     KLDYHIHMNDEHFEEINEIVFPTPEHAASVLGVDEQFPTVLQTKITKLESTGQVLEYS
                     ETYKRSDYYKIKFISCDRDH"
     gene            24331..26118
                     /locus_tag="VXE25_001056"
     CDS             24331..26118
                     /locus_tag="VXE25_001056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262529.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-galactosidase"
                     /protein_id="HEV0771532.1"
                     /translation="MTRFEIRDDFYLDGKSFKILSGAIHYFRVPPEDWYHSLYNLKAL
                     GFNTVETYVAWNLHEPREGEFHFDGDLDLEKFLQIAQDLGLYAIVRPSPFICAEWEFG
                     GLPAWLLTKNMRIRSSDPAYIEAVGRYYDQLLPRLVPRLLDNGGNILMMQVENEYGSY
                     GEDKAYLRAIRQLMEECGVTCPLFTSDGPWRATLKAGTLIEEDLFVTGNFGSKAPYNF
                     SQMQEFFDEHGKKWPLMCMEFWDGWFNRWKEPIITRDPKELADAVREVLEQGSINLYM
                     FHGGTNFGFMNGCSARGTLDLPQVTSYDYDALLDEEGNPTAKYLAVKKMMATHFSEYP
                     QLEPLYKESMELDAIPLVEKVSLFETLDSLSSPVESLYPQKMEELGQSYGYLLYRTET
                     NWDAEEERLRIIDGRDRAQLYVDGQWVKTQYQTEIGEDIFYQGKKKGLSRLDILIENM
                     GRVNYGHKFLADTQRKGIRTGVCKDLHFLLNWKHYPLPLDNPEKIDFSKGWTQGQPAF
                     YAYDFTVEEPKDTYLDLSEFGKGVAFVNGQNLGRFWNVGPTLSLYIPHSYLKEGANRI
                     IIFETEGQYKEEIHLTRKPTLKHIKGENL"
     gene            26115..26591
                     /locus_tag="VXE25_001057"
     CDS             26115..26591
                     /locus_tag="VXE25_001057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006155184.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system
                     mannose/fructose/N-acetylgalactosamine-transporter subunit
                     IIB"
                     /protein_id="HEV0771533.1"
                     /translation="MTIVGCRIDGRLIHGQVANLWAGKLNVSRIMVVDDEVVNNDIEK
                     SGLKLATPPGVKLSILPVEKAAANILAGKYDSQRLFIVARKPDRFLGLVEAGVPLETL
                     NVGNMSQTPETRSITRSINVVDKDVEDFHKLAEKGVKLTAQMVPNDPISDFLSLLK"
     gene            26619..27524
                     /locus_tag="VXE25_001058"
     CDS             26619..27524
                     /locus_tag="VXE25_001058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006149155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS
                     mannose/fructose/sorbose/N-acetylgalactosamine transporter
                     subunit IIC"
                     /protein_id="HEV0771534.1"
                     /translation="MIQWWQILLLTLYSAYQICDELTIVSSAGSPVFAGFITGLIMGD
                     VTTGLLIGGNLQLFVLGVGTFGGASRIDATSGAVLATAFSVSQGIDAPLAITTIAVPV
                     AALLTYFDVLGRMTTTFFAHRVDAAIERFDYKGIERNYLLGAIPWALSRALPVFFALA
                     FGGAFVQSVVDFVEAYKWVADGLTLAGRMLPGLGFAILLRYLPVKRNLHYLAMGFGLT
                     AMLTVLYSYVTGLGGAVAGIVGTLPAEVAEKIGFVNNFKGLSMIGISIVGIFLAVLHF
                     KNSQKVAVAAPSTPSESGEIEDDEF"
     gene            27511..28326
                     /locus_tag="VXE25_001059"
     CDS             27511..28326
                     /locus_tag="VXE25_001059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000185291.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose/fructose/sorbose transporter family
                     subunit IID"
                     /protein_id="HEV0771535.1"
                     /translation="MTNSNYKLTKEDFNQINKRSLFTFQLGWNYERMQASGYLYMILP
                     QLRKMYGDGTPELKEMMKVHTQFFNTSPFFHTIIAGFDLAMEEKDGVGSKDAVNGIKT
                     GLMGPFAPLGDTIFGSLVPAIMGSVAATMAIAGQPWGIFLWIAVAVAYDIFRWKQLEF
                     AYKEGVNLINNMQSTLTALIDAASVLGVFMMGALVATVINFEISYKLPIGEKMIDFQD
                     ILNQIFPRLLPAIFTAFIFWLLGKKGMNSTKAIGIIIVLALALSALGHFALGM"
     gene            28333..28737
                     /locus_tag="VXE25_001060"
     CDS             28333..28737
                     /locus_tag="VXE25_001060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007284837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEV0771536.1"
                     /translation="MTKSLILVSHGRFCEELRGSTEMIMGPQDNIYTVALLPEDGPEE
                     FTAKFEAVIEGLDDFLVFADLLGGTPCNVVSRLIMEGRDIDLYAGMNLPMVIEFINAS
                     LTGADADYKSRAAESIVKVNDLLAGFDDDEDE"
     gene            28990..30156
                     /locus_tag="VXE25_001061"
     CDS             28990..30156
                     /locus_tag="VXE25_001061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004257942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HEV0771537.1"
                     /translation="MLHYTKEDLLELGAEITTREIYQQPDVWREAFEFYQAKREEIAA
                     FLQEIADKHDYIKVILTGAGTSAYVGDTLLPYFKEVYDERKWNFNAIATTDIVAKPAT
                     YLKKDVATVLVSFARSGNSPESVATVDLAKSLVDELYQVTITCAADGKLALQAHGDDR
                     NLLLLQPAVSNDAGFAMTSSFTSMMLTALLVFDPTEFAVKSERFEVVSSLARKVLDKV
                     EDVKELVDLDFNRVIYLGAGPFFGLAHEAQLKILELTAGQVATMYESPVGFRHGPKSL
                     INDNTVVLVFGTTTAYTRKYDLDLVREVAGDQIARRVVLLSDQAFGLENVKEVVLGCG
                     GVLNDIYRVFPYIVYAQLFALLTSLKVENKPDTPSPTGTVNRVVQGVIIHEYQK"
     gene            30272..31309
                     /locus_tag="VXE25_001062"
     CDS             30272..31309
                     /locus_tag="VXE25_001062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose mutarotase"
                     /protein_id="HEV0771538.1"
                     /translation="MKAYTERVFGNVEGEDVLAYRFETDGGYQLEVMTYGATILRYVA
                     PDKAGNFANVILGFDDFDSYVGNSPKHGASVGPVAGRIAGATFELNGKTYDLEVNNAS
                     NCNHSGSTGWDSSLFEVEEVSDHGLTLYTERTDGTGGFPGNLKIWISYHLEETGAYEI
                     IYKVTTDQDTLVNPTNHSYFNLSGDFTQTIDRHVFQLNTEGIYSIAPDGVPAKTPEAN
                     RDVVKHIYNGTLLKDIFAEEDEQIQLASGLDHPFALPAGHDNAGFLYDQNSGRFLLFK
                     TEAPCFVVYTANFVDESVIIGGQPMLQHNGIALEAQALPDAIHSDLKGQVILKAGQTF
                     TSKTRYELVVK"
     gene            31517..32371
                     /locus_tag="VXE25_001063"
     CDS             31517..32371
                     /locus_tag="VXE25_001063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000220702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HEV0771539.1"
                     /translation="MTYEYKSHIYLAETVLNVKDLASQTAFYQQVIGLEILSQTETES
                     ILGLGGKVLVQLIQAQESGEVREHYGLYHLAILLPTRKALADVLKHLTDLQIPLVGGA
                     DHGYSEAIYLEDLEGNGIELYRDKPVSTWNIREDGRIIGVTEALAAQDIYELGERVEP
                     FILAEGTRMGHIHLSVKDSRKSSQFYQKVLGLENKFSVPGASWIAAGDYHHHLAVNEW
                     GGKGLASRKQGLPGLAYYVIEVAHKKELLTIAQRAQEVDAPIKWMTSIQLEITDSDGI
                     VTRIRLAR"
     gene            32521..32778
                     /locus_tag="VXE25_001064"
     CDS             32521..32778
                     /locus_tag="VXE25_001064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001845567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-sensing transcriptional repressor"
                     /protein_id="HEV0771540.1"
                     /translation="MTNSKYITCLKRSEGQLCGIQKMIEGDCDCADIVTQLTAVRSSV
                     ERVIEMIITENLTECINQPLDDSEAQKERLEKAIRYLIKRK"
     gene            complement(32820..>33214)
                     /locus_tag="VXE25_001065"
     CDS             complement(32820..>33214)
                     /locus_tag="VXE25_001065"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=3
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771541.1"
                     /translation="VVDGTDEVSSKHCFEVVDRTDEVSSKHCFEVVDRTDEVSSKHCF
                     EVVDRTDEVSNHIYGKVKLTWFEEIFEEYKSLHNKTHITKVLMNCTPKVRQKKSNFLG
                     SIHSTPDTMRFFNFKDFLQLLLTHIKLF"
BASE COUNT         9161 a         6505 c         7778 g         9770 t
ORIGIN      
        1 gtttttagaa atactaaaat ttttttcttt acttaataat gatatgaaat catttcggtt
       61 ttgttaactt gtaattctta tattttctag gtagaacgtt tgttctgcct atttttttat
      121 ccaaaaagtg cagttgggag ggagataggc tcatttggga aggaagtcca gtttttgttt
      181 agtgattggg gtaagatagt tgttatcaga tgagtttata ctcttcgaaa atcaaattca
      241 aaccacgtca acgtcgcctt gccgtatata tgtgactgac ttcgtcagtc ctatctacaa
      301 cctcaaaaca gtgttttgag cagcctgcgg ctagtttcct agtttgctct ttgattttca
      361 ttgagtatta gggaaaagga gatgaatatg aaatttggga aacgtcacta tcgtccgcaa
      421 gtggatcaga tggactgcgg tgtagcttca ttagccatgg tttttggcta ctatggtagt
      481 tattattttt tggctcactt gcgagaattg gctaagacga ccatggatgg gacgacggct
      541 ttgggcttgg tcaaggtggc agaggagatt ggttttgaga cgcgagccat taaggcggat
      601 atgacgcttt ttgacttgcc ggatttgact tttccttttg ttgcccatgt gcttaaggaa
      661 gggaaattgc tccactacta tgtggtgact gggcaggata aggatagcat tcatattgcc
      721 gatccagatc ccggggtgaa gttgactaaa ctgccacgtg agcgttttga ggaagaatgg
      781 acaggagtga ctctttttat ggcacctagt ccagactata agccttataa ggaacaaaaa
      841 aatggtctgc tctcttttat ccctatatta gtgaagcagc gtggcttgat tgccaatatc
      901 gttttggcaa cactcttggt aaccgggatt aacattgtgg gttcttatta tctgcagtct
      961 atcattgata cctatgtgcc agatcagatg cgttcgacac tagggattat ttctattggg
     1021 ctagtcatcg tctacatcct ccagcaaatc ttgtcttacg ctcaggagta tctcttgctt
     1081 gttttggggc aacgcttgtc gattgacgtg attttgtcct atatcaagca tgtttttcac
     1141 ctccctatgt ccttctttgc gacacgcagg acaggggaga tcgtgtctcg ttttacagat
     1201 gctaacagta tcatcgatgc gctggcttcg accatccttt cgattttcct agatgtgtca
     1261 acggttgtca ttatttccct tgttctattt tcacaaaata ccaatctctt tttcatgact
     1321 ttattggcgc ttcctatcta cacagtgatt atctttgcct ttatgaagcc gtttgaaaag
     1381 atgaatcggg ataccatgga agccaatgcg gttctgtctt cttctatcat tgaggacatc
     1441 aacggtattg agactatcaa gtccttgacc agtgaaagtc agcgttacca aaaaattgac
     1501 aaggaatttg tggattatct gaagaaatcc tttacctata gtcgagcaga gagtcagcaa
     1561 aaggctctga aaaaggttgc ccatctcttg cttaatgtcg gcattctctg gatgggggct
     1621 gttctggtca tggatggcaa gatgagtttg gggcagttga ttacctataa taccttgctg
     1681 gtttacttta ccaatccttt ggaaaatatc atcaatctgc aaaccaagct tcagacagcg
     1741 caggttgcca ataaccgtct aaatgaagtg tatctagtag cttctgagtt tgaggagaag
     1801 aaaacagttg aggatttgag cttgatgaag ggagatatga ccttcaagca ggttcattac
     1861 aagtatggct atggtcgaga cgtcttgtcg gatatcaatt taaccgttcc ccaagggtct
     1921 aaggtggctt ttgtggggat ttcagggtca ggtaagacga ctttggccaa gatgatggtt
     1981 aatttttacg acccaagtca aggggagatt agtctgggtg gtgtcaatct caatcagatt
     2041 gataaaaaag ccctgcgcca gtacatcaac tatctgcctc aacagcccta tgtctttaac
     2101 ggaacgattt tggagaatct tcttttggga gccaaggagg ggacgacaca ggaagatatc
     2161 ttacgggcgg tcgaattggc agagattcga gaggatatcg agcgcatgcc actgaattat
     2221 cagacagaat tgacttcgga tggggcaggg atttcaggtg gtcaacgtca gagaatcgct
     2281 ttggcgcgtg ctctcttgac agatgcgccg gtcttgattt tggatgaggc gactagcagt
     2341 ttggatattt tgacagagaa gcggattgtc gataatctca tggctttgga caagaccttg
     2401 attttcattg ctcaccgctt gactattgct gagcggacag agaaggtggt tgtcttggat
     2461 cagggcaaga ttgtcgaaga aggaaagcat gctgatttgc ttgcacaggg aggcttttac
     2521 gcccatttgg tcaatagcta gaaagaggag aggatgaaac cagaattttt agaaagtgcg
     2581 gagttttata atcgtcgtta ccataatttt tccagtagtg tgattgtacc catggccctt
     2641 ctgctcgtgt ttttacttgg ctttgcaact gttgcagaga aggagatgag tttgtccact
     2701 agagctacta tcgaacccag tcgtatcctt gcaaatatcc agtcaactag caacaatcgt
     2761 attcttgtca atcatttgga agaaaataag ctggttaaga agggggatct tttggttcaa
     2821 taccaagaag gggcagaggg tgtccaagcg gagtcctatg ccagtcagtt ggacatgcta
     2881 aaggatcaaa aaaagcaatt agagtatctg caaaagagcc tgcaagaagg ggagaaccac
     2941 tttccagagg aggataagtt tggctaccaa gccacctttc gcgactacat cagtcaagca
     3001 ggcagtctta gggctagtac atcgcaacaa aatgagacca tcgcgtccca gaatgcagca
     3061 gctagccaaa cccaagccga aatcggcaac ctcatcagtc aaacagaggc taaaattcgc
     3121 gattaccaga cagctaagtc agctatggaa acaggtgctt ccttggccag tcagaatcta
     3181 gcctactctc tttaccagtc ctacaagtct cagggcgagg aaaatcccca aactaaggtt
     3241 caggcagttg cacaggttga agcacagatt tctcagttag aatctagtct tgctacttac
     3301 cgtgtccagt atgcaggttc aggtacccag caagcctatg cgtcagggtt aagcagtcaa
     3361 ttggaatccc ttaaatccca acatttggca aaggttggtc aggaattgac ccttctagcc
     3421 cagaaaatct tggaggcaga gtcaggtaag aaggtacagg gaaatctttt agacaagggg
     3481 aaaattacgg cgagtgagga tggggtgctt catcttaatc ctgagaccag tgattctagc
     3541 atggttgcag aaggtgccct actagcccaa ctttatccat ctttggaaag agaagggaaa
     3601 gccaaactca cagcctatct aagttcaaaa gatgtagcaa gaatcaaggt cggtgattct
     3661 gttcgctata ctacgactca tgatgccggg aatcaacttt tcctagattc aactattaca
     3721 agtattgatg cgacagctac taagactgag aaagggaatt tctttaaaat agaggcggag
     3781 actaatctaa cttcggagca ggctgaaaaa cttaggtacg gggtggaagg ccgcttgcag
     3841 atgattacgg gcaagaaaag ttatctacgt tattatttgg atcaattttt gaacaaagag
     3901 taatgttcgt gtttttagag ttaaataatt tttaaactgt gagaaagatt cttcttgcag
     3961 ttttttcttt acaatttttg aaaaacatct actatttatt cggttaaatt cttgtgtttt
     4021 ttggtttttt gtggtaaaat gtgctcaagt aatacgaaag gcgaacttta aaatgtcaaa
     4081 acaattgatc tattcgggaa aagctaaaga tatctataca actgaggatg aaaatcttat
     4141 tatttcaact tacaaggacc aggcgactgc tttcaacggt gtcaagaagg agcagattgc
     4201 aggtaaggga gtcttgaata atcagatctc atcttttatt tttgagaaat taaatgcggc
     4261 tggtgtggcg actcactttg tggagaaact ttcagacacg gaacaactca ataaaaaggt
     4321 taagattatt cctttggaag tcgtgctccg caactatact gctggttctt tttcaaaacg
     4381 ttttggtgtg gatgagggaa tcgccttgga gactccgatt gtcgaatttt actacaaaaa
     4441 tgatgatttg gatgatccat ttatcaatga tgagcatgtg aaattcctac agattgcggg
     4501 tgaccagcag attgcctact tgaaggaaga aacgcgtcgt atcaatgaac tattgaaagt
     4561 ctggtttgct gagattgggc ttaaattgat tgactttaag ctagagttcg gttttgacaa
     4621 ggatggcaag attatcttgg cagacgaatt ttcaccagat aactgccgct tgtgggacgc
     4681 tgatggcaac cacatggata aggatgtttt ccgtagagga ttgggagaac taaccgacgt
     4741 ttatgagatt gtttgggaaa agttgcagga attgaaataa tctgtttgca acggaaaacc
     4801 ttcgtctctc aactaaaagg actcaggctg aaaaggtccc ccagaccttt tcactctgta
     4861 gagaactagg tgaactaaca gatgtttacg aaattgtctg ggaaaagttg cagggtttaa
     4921 aataacaacc tcaaggctgt ttgggaatat tgcaagagct gaaataaagg aataagaatt
     4981 gatggataaa cgtatttttg ttgaaaaaaa ggctgatttt caggtcaagt cagagagttt
     5041 ggttagagag ttccagcaca acttgggact gtcaagcttg aaaagtattc gtattgtgca
     5101 agtatatgat gtatttgact tggctgagga cttgtttgca cctgcagaga agcacatttt
     5161 ctctgagcag ggaaccgacc atgttttaga tgaagtatct gtgcaggcgg atcttgctaa
     5221 ctatgctttc tttgccattg aaagtctgcc agggcagttt gaccagcgtg cagcttcgtc
     5281 acaggaagcc ttgcttttgt tgggaagttc gagtgacgtg acagtcaaca cagcccaact
     5341 ttacttggtg aataaagata ttgatgcgac tgagttggaa gctgtcaaaa actacctgct
     5401 caatccagtt gattctcgtt tcaaggatat cacgacaggg attgccaagc aggagttttc
     5461 agagtcagac aagaccattc caaaattgac tttctttgaa agctatacag cagaagactt
     5521 tgctcgctac aaggccgagc aagggatggc catggaagtg gatgatttgc tctttatcca
     5581 agactacttt aagtcaatcg ggcgcgtgcc aactgagact gaactcaagg ttttggacac
     5641 ttactggtct gaccactgcc gtcatacgac ttttgagaca gagttgaaac acatcgactt
     5701 ttcagcttct aaatttcaaa agcaattgca gtcaacctat gacaagtata ttgccatgcg
     5761 cgaggagtta ggtcggtctg aaaaaccaca aaccttgatg gatatggcga ctattttcgg
     5821 tcgttatgag cgtgctaacg gacgattgga tgatatggaa gtctctgacg aaatcaatgc
     5881 ctgctcagtt gaaattgaag tggatgttga tggtgtcaag gaaccttggc tcctcatgtt
     5941 taaaaatgaa acccacaacc atccaacaga aattgagcca tttggtggag cggctacctg
     6001 tatcggtgga gctattcgtg atccgttgtc aggccgttcc tatgtttacc aagccatgcg
     6061 tatttcaggt gctggtgata ttacagcacc gatttcggaa actcgtgctg ggaaattgcc
     6121 acaacaagtc atttctaaaa cagcagctca tggttattct tcatatggta accagattgg
     6181 gcttgccaca acctacgttc gtgaatactt ccacccaggc tttgtagcta aacgtatgga
     6241 acttggtgcc gttgttggtg cggctcccaa gggcaatgtt gtccgtgaaa aacctgaagc
     6301 aggtgatgtg atcatccttc tcggaggcaa aacaggtcgt gatggtgtcg gtggtgcgac
     6361 gggctcttct aaggttcaaa cagttgagtc tgtagagact gctggtgctg aggttcaaaa
     6421 aggaaatgcc atcgaagaac gcaagattca gcgcctcttc cgtaatggca atgtcactcg
     6481 tctgatcaag aagtccaatg actttggggc aggcggcgtc tgtgtggcta tcggtgaatt
     6541 ggcagacggt cttgaaatcg acctcaacaa ggtgcctctt aaataccagg gcttgaatgg
     6601 tacagaaatt gccatctctg aatcacaaga acggatggcg gtcgtggttc gtcctgaaga
     6661 tgtggatacc ttcgttgccg aatgtaacaa agaaaatatt gatgctgttg tggtggcgac
     6721 agtaactgaa aaaccaaatc ttgtcatgca ctggaatggt gagacaatcg ttgacttgga
     6781 gcgtcgtttc cttgacacca atggtgtgcg cgtggttgtc gatgccaaag ttgtggacaa
     6841 ggatgtcaaa ctcccagaag agcgtcaaac atctgctgaa acactggaat cagataccct
     6901 tacggttcta tctgacctca accatgcaag tcaaaaagga ttacagacta tctttgactg
     6961 ctctgttgga cgctcaacgg ttaatcaccc acttggtggt cgttaccaac tcacaccaac
     7021 tgaggcatct gtgcagaaat tgccagttca acacggtgtg actcatactg cgtcggtcat
     7081 tgctcaaggt ttcaacccat atgtagctga atggtctcca taccacggtg ctgcttatgc
     7141 ggttatcgaa gcaactgctc gtttggtggc tgctggtgcc aactggtcta aggctcgttt
     7201 ctcttaccaa gaatatttcg agcggatgga caagcaagca gagcgtttcg gtcagccagt
     7261 agctgctctt ctaggttcta ttgaagcaca aattcagctt ggcttgccat ctatcggtgg
     7321 taaggactcc atgtctggta cctttgaaga attgaccgtt ccgccaacct tggttgcctt
     7381 tggggtgacg acggcagata gccgtaaggt gctctctcca gaatttaaag ctgttgggga
     7441 aaatatctac tacatcccag gtcaagccct ctctgcagag attgattttg acttgattaa
     7501 gaaaaatttt gctcagtttg aagcaagcca agctgaccat aaagtgacgt ctgcatcagc
     7561 tgtcaaatac ggtggtgtag ttgaaagttt ggctcttgct acctttggaa actatattgg
     7621 tgcagaggtg accttgcctg aacttaaaac agctttgaca gctcaattag gcggctttgt
     7681 cttcacatct cctgaagaaa ttgctggagt agagaagatt ggacaaacga aagcagactt
     7741 tacactgact gtcaacggtg tgaagctaga tggacacaag cttgacagtg catttcaagg
     7801 gacattggaa gaagtttacc caacagaatt tacccaagcg aaagaactag aagaagtacc
     7861 agctgtggca tcagatgttg tgattaaagc caaagaaaag gttgaaaaac ctgtggttta
     7921 catcccagtc tttccaggaa ccaactcaga atatgattca gctaaggcct tcgaaaaaga
     7981 aggtgcagag gtcaatttgg tgccattcgt gaccttgaat gaagaagcta ttgtcaagtc
     8041 agttgaaact atggttgaca atatcgacaa gactaatatt ctcttctttg ccggtggatt
     8101 ctcggctgcg gatgaaccag atggttcagc taagtttatc gtcaatatcc tgcttaatga
     8161 aaaagtgcgt gtggctattg atagctttat cgcccgtggt ggcttgatta tcggtatttg
     8221 taatggattc caagccttag tcaaatcggg tctcctacca tacggaaact ttgaagatgc
     8281 taacagtact agtccaaccc tcttctacaa tgatgccaac caacacgtgg ccaagatggt
     8341 ggaaactcgc attgccaata ccaactcacc atggttggct ggtgtgcaag tgggcgatat
     8401 ccacgctatt cctgtttcgc acggtgaagg gaagtttgtc gtgacggctg aggaatttgc
     8461 agagctccgt gacaatggac aaattttcag ccaatacgtt gactttaacg gtaaaccaag
     8521 tatggattct aagtacaatc cgaatggttc tgtccatgcc atcgaaggaa ttaccagcaa
     8581 gaatggtcaa atcatcggta agatgggcca ctcagaacgt tatgaggatg gtcttttcca
     8641 aaatatccca ggcaataaag accaacacct gttcgcatca gcggttaaac atttcactgg
     8701 aaaataagac ttacagattt tctaatagat agtatcagta atgtaaaagt catgtaaatc
     8761 tagctcttga tgattacaaa tgaaaattag gtataaaaaa tgacatacga agtaaaatct
     8821 cttaatgaag aatgtggtgt tttcggtatt tggggacatc cagatgctgc taagttgacc
     8881 tattttggac tccacagtct tcaacaccgt ggtcaggagg gggcaggaat cctctccaat
     8941 gatcaaggac aactgaagcg ccatcgtgac atggggcttt tatcagaagt tttcagaaat
     9001 ccagccaatt tggataaatt gacaggagct ggtgcgattg ggcatgtgcg ttatgcgact
     9061 gctggcgaag cttctgttga taacatccag cccttcctct tccgttttca cgatatgcag
     9121 tttggcttgg ctcataatgg aaatctgacc aatgcagcct ctctcaagaa agaactggaa
     9181 caaagaggag caattttcag cgcgacttcg gactctgaaa tcttggctca cctcattcgt
     9241 cgtagtcata atcctagcct gatgggcaaa atcaaggaag cgctcagcct tgtcaaaggt
     9301 ggttttgcct atatcttgct gtttgaggac aagttgattg cggctcttga ccctaatggc
     9361 tttcgtccgc tttctatcgg gaaaatggcc aacggagcgg tggttgtttc ctctgaaacc
     9421 tgtgcttttg aggtcattgg tgccgagtgg attcgtgatt tgaagccagg tgagattgtg
     9481 atcattgatg acgagggcat tcagtatgac agctatacag atgatactca gttggcgatt
     9541 tgttctatgg agtatatcta ctttgctcgc cctgattcta atatccacgg tgtcaatgtc
     9601 catacggcac gtaagagaat gggagcgcaa ttggcgcgag aatttaagca tgaggcagat
     9661 attgtagttg gtgtgcccaa ttcttcccta agcgcggcta tgggatttgc ggaagaatca
     9721 ggcttaccaa atgaaatggg tctgatcaaa aaccaataca cccagcgaac ttttatccaa
     9781 ccgactcaag aattgcggga gcaaggagtg cggatgaaac tgtctgctgt ttcgggtgtt
     9841 gtcaaaggca aacgtgtggt catggtggat gattccattg tacgtggaac aacctctcgt
     9901 cgtatcgttc agctcttgaa agaagcgggt gcgactgagg ttcacgttgc cattggaagt
     9961 cctgcactag cgtatccatg tttctacggg attgatatcc agacccgtca ggagctgatt
    10021 gcagccaatc atacggtcga agaaactcgc caaatcattg gtgcggacag tctgacttat
    10081 ctttcaattg atggcttgat tgagtcgatt ggtatcgaaa cagatgcgcc gaacggtggt
    10141 ctctgtgtcg cttactttga cggtgactac ccaacgcctc tctatgacta cgaagaagac
    10201 tatcgtagaa gtttggaaga aaagaccagt ttttacaagt aggcgacaga ttctccatta
    10261 aagaaaagga aaaaacaaat gacaaataaa aatgcatatg cccagtcggg tgtggatgtt
    10321 gaagcgggtt atgaagttgt tgaacggatt aaaaagcacg tggcccgtac ggagcgtgca
    10381 ggtgtcatgg gagctcttgg tggctttggt ggtatgtttg acctttccaa gactggggtt
    10441 aaagaacccg tcttgatttc agggactgac ggtgtcggaa ccaagctcat gttggctatc
    10501 aagtacgaca agcacgatac catcgggcag gactgtgtgg ccatgtgtgt caacgacatc
    10561 attgctgcag gtgcggaacc cctctatttt ctcgactacg tagcgacagg gaagaatgaa
    10621 ccagctaagc tagaacaagt ggttgctggt gtggcagaag gttgtgtgca ggctggtgct
    10681 gccctcatcg gtggggaaac ggctgaaatg ccgggcatgt acggcgaaga cgactatgac
    10741 ttggctggtt ttgcggtcgg tgtggctgaa aaatctcaaa tcattgacgg ttcaaaggtg
    10801 gtagagggag atgttcttct cggatttgct tcaagtggga ttcactcaaa tggttactct
    10861 ttggttcgtc gtgtctttgc ggattacaca ggtgaggaag tcctaccaga attggaaggc
    10921 aagaaactta aggaagttct acttgagccg actcgtatct atgtcaaggc tgtcttgccg
    10981 ctcatcaaag aagagttggt caacggcatt gcccacatca caggtggtgg ctttatcgaa
    11041 aatgtccctc gtatgtttgc agatgaccta gctgctgaaa ttgatgaaag caaagttcca
    11101 gtgcttccaa ttttcaaagc ccttgaaaaa tatggtcaga ttaaacacga agaaatgttt
    11161 gaaatcttca atatgggtgt gggacttatg ttggcggtca gccctgaaaa tgtagagcgt
    11221 gtaaaagaat tgttggatga agcagtctat gaaattggtc gcatcgtcaa gaaagaaaac
    11281 gaaagtgtca ttatcaaatg aaaaaaatag cggtttttgc ctctggtaat ggctcaaatt
    11341 ttcaggtgat tgccgaagaa tttccagtgg agtttgtctt ttcagaccat cgtgatgcct
    11401 atgtgcttga gcgtgcaaag cagctcggcg ttctgtccta tgcttttgaa ctcaaggagt
    11461 ttgagagcaa gacagactac gaagcagccc ttgtcgaact cttggaagaa caccagattg
    11521 acttggtttg cctagcaggc tacatgaaaa tcgttggacc aaccttattg tcggcttatg
    11581 aaggtcggat tgtcaacatt catccagcct acttgccaga atttccagga gctcatggga
    11641 ttgaggatgc ttggaatgct ggcgtgggtc agtctggtgt gaccattcac tgggtggatt
    11701 cgggtgtgga tacaggccag gtcatcaaac aggttcgtgt gccacgacta gctgatgata
    11761 ccattgacag atttgaagct cgcatccatg aagcagagta caggttgtat ccggaagtag
    11821 tgaaggctct atttacagat tgactttttg atgattcata tgatatcttt gattttaaat
    11881 tggagtcagt gtttgttgaa gacggcttca aacggaggta tttgtaatgt tagaatctaa
    11941 aaaaacaact cgatatgtat tttatgtcta tctgatgtta ttaacttggg gaatcttatt
    12001 taagtttgaa acaaatcctg aatttatagc atttttctta gctccaaggt atatcaattg
    12061 gattccattt tcagaaccac taatagtcga tggaaaaatt gtttttgctg aaatgttatt
    12121 taatctgatt tcctttattc cattaggtgt ttgtttccct ttgataaaaa ctaatttatc
    12181 tagtttaaga atagtcggga caggtttctt gattagttta ttgtttgagt gcttacagta
    12241 tattttagca ataggtataa cagatataac ggatttgact ttaaatacgc taggtgtctg
    12301 tgtaggctta ctgatttatc aaatttttat aagagtgttc aaatcacaga ctagaaaatg
    12361 gatcaatatc ttaggtatgc ttagccttgg ttttgcttat cttgttttac tgttactgca
    12421 tttaattggt gtttaactaa tgattaaaaa ggagaatata atgactaaac gcgtcttaat
    12481 cagcgtctca gacaaagcgg gcattgttga atttgcccaa gaactcaaaa aacttggttg
    12541 ggagattatc tcaacaggtg gaactaaggt tgcccttgat aatgctgggg tggataccat
    12601 tgctatcgat gatgtgactg gtttcccaga aatgatggac ggtcgtgtga agaccctcca
    12661 cccaaatatc cacggagggc ttctcgctcg tcgtgacttg gatagccact tggaagcggc
    12721 taaggacaac aagattgagc tcattgacct tgtggtggtc aacctttacc catttaagga
    12781 aactatcctt aaaccagatg tgacttatgc tgatgcagtt gaaaatatcg atattggtgg
    12841 gccatctatg cttcgttcag cagcgaaaaa tcatgccagt gttacagttg tggtagatcc
    12901 tgctgactac gctgtggttt tggacgaatt ggcagcaaac ggcgaaacct cttatgaaac
    12961 tcgccaacgt ttagcagcca aagtatttcg tcacacagcg gcttatgacg ccttgattgc
    13021 agaatacttc acagctcaag tgggtgaaag caagcctgaa aaactcactt tgacttatga
    13081 cctcaagcaa ccaatgcgtt acggtgagaa tcctcaacaa gacgcggact tttaccagaa
    13141 agctttgcct acagattact ctattgcttc agccaaacag ctcaacggga aagaattgtc
    13201 atttaataat atccgtgatg cagatgctgc tatccgtatc atccgtgact tcaaagatag
    13261 tccaaccgtt gtggctctca aacacatgaa tccatgtgga attggtcaag ctgatgacat
    13321 cgagactgct tgggactacg cttatgagtc tgacccagta tctatctttg gtgggattgt
    13381 cgtcctcaac cgtgaggtgg atgctgcgac agctgagaag atgcacggcg ttttcctcga
    13441 aatcatcatt gccccaagct atacggatga agcgctagct attttgatca ataaaaagaa
    13501 aaacttgcgt atccttgcct tgccatttaa tgctcaagag gctagcgaag tggaagcaga
    13561 atacacaggt gtagtcggtg gacttctcgt gcaaaatcaa gacgtggtca aggaaagccc
    13621 agctgactgg caagtggtga ccaaacgtca gccaactgag acagaagcga ctgctcttga
    13681 gttcgcttgg aaggctatca agtacgtcaa atcaaatggt attatcgtga ccaacgacca
    13741 catgacactt ggtgttggtc caggtcaaac caaccgtgtg gcttctgttc gccttgccat
    13801 tgaccaagcc aaagatcgtc tgaacggggc ggtccttgct tcagatgcct tcttcccatt
    13861 ttcggataac gtggaagaaa tcgccaaagc aggaattaag gccatcatcc agcccggtgg
    13921 ctctgtccgt gaccaagaat ccatcgaagc agcgaataaa tacggcttga ctatggtctt
    13981 tacaggtgtg agacatttta gacattaaga agataaaagg gaagaaaaca gtttctttcc
    14041 ttttttggct taaaatgcta actgaaacaa gattaaaacg aacttttttg atataatgtt
    14101 ggtaaataat tcgcaaaaga ggttgaggaa tgaaactgct tgttgtcggt tctggtggtc
    14161 gtgagcatgc gattgctaaa aagttacttg aatcaaaaga cgtggaaaaa gtctttgtag
    14221 ctcctgggaa tgatgggatg actctggatg gtttggaatt ggtaaatatc tctatttccg
    14281 aacattctaa attgattgac ttcgcaaaga ccaatgatgt tgcttggacc tttatcggtc
    14341 cagatgatgc ccttgctgct ggtatcgtgg atgattttaa ccaagctggg cttaaggcct
    14401 ttggtccgac tagggctgca gcggagctgg agtggtccaa ggattttgcc aaggaaatca
    14461 tggtcaaata tggtgtttcg acagcagcct atggcacatt ttcagatttc gaggaagcca
    14521 aggcctatat cgaaaagcat ggtgcgccta tcgtagtcaa ggcggatggc ttggcgcttg
    14581 ggaagggtgt cgtcgttgct gagacggttg agcaagcggt cgaagccgct catgagatgc
    14641 ttttggacaa taaatttggt gactcaggtg cgcgcgtggt tattgaggaa ttccttgaag
    14701 gagaggaatt ttcactcttt gcctttgtca atggtgataa gttctacatc atgccaacgg
    14761 ctcaggacca caaacgtgcc tacgatggcg acaaagggcc taacacgggt ggtatgggtg
    14821 cctatgcgcc agttccacac ttaccacaga gtgtagttga tacagcggtt gacaccattg
    14881 tcaagccagt tctagaaggg atgattaaag aaggtcgccc ttatctaggt gtcatttacg
    14941 cagggcttat cttgacagca gacgggccga aggtcatcga gttcaactct cgatttggag
    15001 atcctgaaac tcagattata ttgcctcgtt tgacctctga ctttgctcaa aatatcacag
    15061 atatcctgga tagcaaggag ccaaatatca tgtggacgga caagggtgtg actctgggtg
    15121 tggttgtcgc atccaagggc tacccgctag actatgaaag gggcgttgag ttgccagcca
    15181 agacagaagg cgatgtcatc acctactatg caggggctaa gtttgcggaa aatagcagag
    15241 cactgctctc aaacggcgga cgagtttata tgctggttac cacagtagcc accgtcaaag
    15301 aagcccaagc cagcatctac caagaactat cccaacaaaa aatagaagga ctcttctacc
    15361 gaacagatat cggaagcaag gcaattaagt aaagatataa gaataacgcg acgcagtcgc
    15421 caaacacgat aatggtcgtc gtggtgaaaa gaccagaaca gtgaatgttc tggtcagggg
    15481 gaaactttga gaccttaggc tcaaagttta ggaatgaaac cgaaggtttg cttccgcctc
    15541 catcacctaa gaccattatc aaaaagaaaa ataaaaattc acaaaatacg ttaatggtcg
    15601 tatggtttgc gagcgttagc gagcaaatat agaataatca ccgccgttgt gaaagaacga
    15661 ttggatgata atccaatcgt tcagggaaat tggaagacct tgggtttcca atttaggcat
    15721 gagacacctt tggtggctgc tgccgtccct cacaagctaa ggtgattgtt gaaaaagagg
    15781 aaaaaggaga agaaatgaaa ccagtaattt ccatcatcat gggttcaaaa tccgactggg
    15841 caaccatgca aaaaacagca gaagtcctag accgcttcgg tgtagcctac gaaaagaaag
    15901 ttgtttccgc acaccgtaca ccagacctca tgttcaaaca tgcagaagaa gcccgtagtc
    15961 gtggcatcaa gatcatcatc gcaggtgctg gtggcgcagc gcatttgcca ggcatggtag
    16021 ctgccaaaac aacccttcca atcattggtg tgccagtcaa gtctcgtgct cttagtggag
    16081 tggattcact ctattctatc gttcagatgc cgggtggggt gcctgttgcg accatggcta
    16141 tcggtgaagc tggagcgact aacgcagcta tctttgccct ccgtctcctc tctgtagaag
    16201 ataagtccat tgcggatgca cttgccaact ttgctgaaga acaaggaaaa atcgcagagg
    16261 agtcgtcaaa tgagctcatc taaaacaatc ggaattatcg gtggcggtca actgggtcag
    16321 atgatggcca tttctgctat ctacatgggc cacaaggtta tcgcgctgga tcctgcggcg
    16381 gattgcccgg cctctcgcgt ggcggaaatc attgtggcac cttataacga tgtggacgcc
    16441 ctccgtcagt tggcagaccg ttgcgatgtc ctcacttatg agtttgaaaa tgtcgacgct
    16501 gacggtttgg atgccgttat caaggatgga caactccctc aaggaacaga tctgctccgc
    16561 atttcgcaaa atcgtatttt tgaaaaggac tttttgtcaa acaaggctca agtcactgtg
    16621 gcaccctaca aggtcgtgac ttctagccta gacttggcag atatcgactt gtcgaaaaac
    16681 tatgtcctca agactgcgac tggtggctac gatggtcatg gacaaaaggt tattcgttca
    16741 gaagcagact tggaagcagc ctatgcgcta gcagactcag cagactgcgt cttggaagaa
    16801 tttgtcaact ttgaccttga gatttctgtc atcgtgtcag gaaatggcaa ggaggtgacg
    16861 tttttcccag ttcaggaaaa tatccaccgc aacaatatcc tgtctaagac catcgtacca
    16921 gcccgcattt ctgaaagtct agtagacaag gctaaagcta tggcagtgcg aatcgcagaa
    16981 caactcaact tgtctggaac tctctgtgtg gaaatgtttg cgactgatga tgacgttatt
    17041 gtcaatgaaa tcgccccacg accacataac tctgggcact attctattga agcctgtgat
    17101 ttctctcagt ttgacaccca tattctcggt gttctcggag caccattacc agtcatcaaa
    17161 ctccatgcgc ctgccgtcat gcttaacgtt ctcggccagc atgttgaggc cgctgaaaaa
    17221 tatgtcacag aaaattcaag cgcccacctc cacatgtatg gtaaaataga agcgaagcac
    17281 aaccgcaaga tgggacatgt gactttgatt agtaatgaac cagatagtgt ggatgagctt
    17341 ggggaaggga ttgattttta ggacaagtct atgatacaaa ttatcgttaa tacatttatt
    17401 gaaaaggata agactggagc agttgttgaa gtgttgtatg ccagtgctga ccaagataag
    17461 gtacaagcta aatatgaaga actagctgca caataccccg aaaattattt agctatctat
    17521 gatgtaccgc tggatacgga tttgaataca ctagatcatt acccgtctgt gtttattgga
    17581 aaagaggagt ttgagtagaa atcttggttt acctagatag cttattccca acagcttaag
    17641 aagaaaggaa aaattaacac atgatcaacc gttactctcg ccctgagatg gcgaatattt
    17701 ggagtgaaga aaataaatac cgtgcttggc ttgaggtgga aatcctctct gacgaggcat
    17761 gggctgagtt gggggaaatc cctaaggaag atgtggcttt gattcgcaag aaggcggact
    17821 ttgacatcga ccgtattttg gaaattgagc aggagacgcg ccacgatgtg gtggctttca
    17881 cgcgtgcggt ttctgagact cttggtgaag agcgcaagtg ggttcactat gggttaactt
    17941 ctactgacgt ggtggatact gcttatggtt acctctacaa gcaggccaac gacatcatcc
    18001 gtcgtgacct tgaaaacttc actaatatca tcgctgacaa ggccaaggag cacaagttca
    18061 ccatcatgat ggggcgtact catggtgtgc acgctgagcc gacaaccttt ggtcttaaat
    18121 tagcaacttg gtacagcgaa atgaaacgca atatcgagcg cttcgagcat gcggctgctg
    18181 gtgtagaagc tggtaagatt tctggtgcgg ttgggaactt tgccaatatc ccaccatttg
    18241 tagaggagta tgtctgcgat aaacttggca tccgtgccca agaaatctct acacaagtcc
    18301 ttcctcgtga ccttcacgct gagtactttg cggttcttgc cagcattgcg acttcaatcg
    18361 aacgtatggc gactgagatt cgtggtctac aaaaatctga gcaacgcgaa gtagaagagt
    18421 tctttgctaa agggcaaaaa gggtcttcag caatgcctca caaacgcaac ccaatcggtt
    18481 ctgaaaatat gactggtctg gcgcgtgtca ttcgtggtca catgattacg gcttatgaaa
    18541 acgtcgctct ctggcacgaa cgcgatattt ctcactcatc agctgagcgt atcatcacac
    18601 cagatacgac cattttgatt gactacatgc tcaaccgttt tggaaatatc gtcaagaact
    18661 tgacagtctt cccagaaaat atgatccgaa acatgaactc gacttttggt cttatcttta
    18721 gccaacgggc tatgttgaca ttgattgaaa aaggcatgac ccgtgagcaa gcctatgact
    18781 tggtgcaacc aaaaacagcc tactcttggg acaaccaagt agactttaaa ccacttcttg
    18841 aggcagattc agaagtaaca tcacgtctca cacaagaaga aatcgatgaa atcttcaacc
    18901 cagtttatta caccaaacga gtggatgata tctttgaacg tcttggacta ggtgattaat
    18961 taaaaaataa acagcgagct tcaatctcgc tgtttatttt ttatcgaaaa gacttagtct
    19021 tcttttcttt tagtgagtcc ataggctgct agtgtggaca tgagtcctgc gactactagt
    19081 cctgcagaat cgtgagttcc tgtttcagga agttttttct ctgttaccac aggagctgga
    19141 tcttgaggaa gagctttgct ttcctcagca ggagcagttg atggagctgg ttggcttggg
    19201 atttctagtt ttggtttttc ttcagcaata gcggcttgtc cgttttcatc gcctacatgt
    19261 gttaccatag ttccgacttc gactatttga gtaacggctt cctgtgctac gacactattt
    19321 acaagtgttt tcacttcctt accatcggca gaagtgctca cagagtagaa gttgctacga
    19381 tgtccattga cgcccttagt aatgacttgt gtttttcctt tgagtaagag tggattttca
    19441 cgagtcactg tggtaaatgg aatttcttct ttttggatat ccagtctagg ttttacctca
    19501 gtagttggtg caagaccact ttcatcaccc ttgtgagtta caggagcgcc aacttcaacc
    19561 acttggttta taacttcttt ggttacctgg ctatcaagga ctgtttctgt tgtttttcca
    19621 ttttcagtga gtacagagat gtaatgagtt cgttcacctt tgactcctgc tgtgataata
    19681 ttttcctgac cagctgggag gttaggattt tctttcttga taacttcaaa tggaatttct
    19741 tcagttcttg tgatgagttc tggtctggtt tcaacattgg cagccacttc attttcatct
    19801 aggcttcctg aatgagttgc agctggtttg aggccttgaa gagcggcttt taggttggct
    19861 acaagtgtgt caagctcagc ttgtttatta cggttgaggt tgtaatttag agctgtttta
    19921 gctgcgtcaa gggcctcaag actttcttta ctatatcctt ctaagtttgt aggaatttta
    19981 gctaattctt cgcggagagc attataatta gcacggaagt agtctttgtt gtggtctgca
    20041 aaggcagtca tgagttcaaa gatttcctct tccttgtact cagcgcttgg tctatctgcc
    20101 cagattgaaa gcatacttcc aactgttgga agatctactt caggatattt ggtagaagct
    20161 agttgattga atggtgtttt tccagtattc tcaatagctt tcttgaggaa accaccacca
    20221 tcttctggtt tttgaccaag aacataatac cagtcaccgt tggtattcaa gaacttataa
    20281 cccttgcttg ctaggtattg aggtgatgcg aggttgtatc cccaccagcc tttagaccag
    20341 taagaaatca agacatcttt gtcaaactga acatcgtcct tgtcttcata gtagaagcca
    20401 tcgttgaagg ccattggttg aagccctctt tctttggcca tagctgcgag ggtgttggca
    20461 tattcggcaa atttgccata gagttgatac cacttgaggt agtaccagcc ttgggcacta
    20521 gtcgcatcgt tggcgtattc gtcagtacca aagttgaaaa tctttgtttt acctgcaaag
    20581 aagtccatgt atttaccgat gagggctttt acaaagttca tcgcttcttc gtttttcaag
    20641 tccatagttg tttttgaaac tttatcaaag tgggcttgag gatttttaat acctaatttt
    20701 tccatggcaa ccagcatagc atccatgtga cctggactgt taatagctgg gatgagaccg
    20761 atgtccttag atttagcgta ttcaattagc tctgttactt ctgcctgtgt tagtgcagta
    20821 ccgtttggat cgtcgtagta agctttagtt ccttcgataa tagctttttt aacgtcatca
    20881 ctagcatagg tttttccgtt ggcagtaatg gtcatatcat cgagtagaaa gcgaagtccg
    20941 tcatttccta gaaggagatg gacatcagaa tatccgagat cactggcctt gtctacgatg
    21001 cgtttgagtt ggtccagagt aaagtatttg cgtccagcat cgattgagat taccttgttt
    21061 ttggcaagtt tttcaacctc acgtttagct tcttcttctt tttgagcttc aggcgtgagg
    21121 gtcaagttgt tgacagtttc ttgaagttta gcaatggctt gatcaatcgt atcttgttgg
    21181 gcacggctaa ggttgctatc gagagagcga atagcttttt cagcttcttt tacggccgtg
    21241 acgctttctg cagtataacg gttcaggtct tttggtacct cgttaagtgc ttgctctgca
    21301 gattcataat cagctgcgaa gtattcagcg ttggcatttg caaaatgacg catgagtttg
    21361 aagaggcgtg atggtgaata acgtgcagat ggagtgtcag tccaagcagc taccatacca
    21421 ccgatgattg ggatatcagc tccttctgtt tttggtacag aagtgattgg tgtgttttta
    21481 ataccattga gcccctgatc gagattgtac cagccttggc catcagcgtt tcgtccaaga
    21541 acgtagtacc aagcatcatt ggtattaagg atttggtgac ctttttcagc tagtagttta
    21601 gaagaagcga catcgtagcc tccccaacca ccagtccaca tagaaacgat gatgtctttg
    21661 tcaaaactac caaagcttgt gtcgctattg tagtagatac cgtcgttaaa ggccattggt
    21721 ttgagaccgt gcgattttac aatacgagcg aggtcattgg cgtaggcaat aaatttttca
    21781 tagcctttta cagggtagcc ttcgtttgga tagtatttat cagcttgaag cacactccaa
    21841 cctttagcat ctgtcgcatc attggcatat tcatcaagtc cgatgttgaa gatttcagtc
    21901 tttttcgcga aataagcagc atacttgtcg ataagggctt ttgtaaaagc gacagcttgt
    21961 tcgttgtcaa gattgacagt acgggctgat tccttcccaa aatagctaaa gttagggttt
    22021 tggattccca attctttcat ggcattgaga atcgcatcca tgtgaccagg actatttact
    22081 gtcggaatga gaccgatacc tttatctttg gcatagttaa tcagatctgt catttgactt
    22141 tctgttaagt gattgccgtt tggatcgttg taataatcat ttgtaccttt ttcaatggcg
    22201 cgtttgacat cgtcactggc ataggtcttg ccgttagctg tgatgctcat atcgtccaac
    22261 atgaaacgga gtccatcatt tccgactaat aggtgtaaat cagtgtagcc ataatgtttc
    22321 gctttatcga tgatttcctt gagctgttct ggtgagaaat atttacgtcc agcatcaata
    22381 gaaacaattt tctttttcgc tagtttttca tttacagttg cagcacgttc ctttcctgcc
    22441 tctgtttccg gtttgtcagc ctctgctttc gcttcatctt ttttagctgg tttatccttg
    22501 tcagtcttgt ctgtatttga ctctttagaa tcaacctctt tcgcttcttc ctttttaggg
    22561 ctagcttctt ctgccttttt attagcagtt tctttttcag cagaagttgg agttaccacc
    22621 tctgctttat cactaggagt tgaactaact tcctcttgtg gtttttcttc tgtttttgga
    22681 agactagcta ccttatcagt agctggagtt tctgtttcta cagtttttgg agcttctggt
    22741 tgaagctctg ctttaggtgt ttcctcagtc cgattttcgg atgattgagg ggaatcagaa
    22801 accgtatgga tggtcggttg gttttctgta gtagtaggag taactccatc ggctgcaaca
    22861 gtctgtgctt ggaaggcaaa tccaattaga acagaagctg ctcctacagc gtatttacga
    22921 atagaaaaac gctgttgttt ttcatgtttc attgcaaaac ctcctgattg cattgttata
    22981 ttgatagcga ttatataaat caacgccttt attttatttc ttatattaac gagagtcaag
    23041 aggagatgac aaaaaactat aataagtata aaaaaatata aaatttaaac ttaagatttc
    23101 agattggtcg gaaaaaatga atatatatat ctagtataat ttttggttct atttctataa
    23161 aatattccac aaattataga atcttccaaa aataggtaag cgctaccttt ttggtgtggt
    23221 ataataagca tagaaaaagc ccaagcgatt agctcaggct ttcttcttag tgatcacggt
    23281 cacatgagat aaatttaatc ttgtagtaat cagatcgttt gtaagtttca ctgtattcta
    23341 aaacttggcc agttgattcg agtttggtga ttttagtttg taggacagta gggaattgtt
    23401 catcgactcc gaggactgaa gccgcatgtt ctggagttgg aaagactatt tcgttgattt
    23461 cttcaaagtg ttcatcattc atgtgaatgt ggtagtctaa cttgaaacga ttatagatag
    23521 aactatagta ttcaaggttt ggataatttg cgttgatata ttgttctggg atgtaggatg
    23581 tatggtagat ataaacgaca ccgtttgatt cgcggatacg ttcaatcttg tagtagaatt
    23641 gatcgccgcg tagacccaat ttttccaagt aaacaagctt gtttccgcgt tcaattgaaa
    23701 gaacagttac cttatcatct ttagcattga agagttcaat atctgaaaac tctacaagct
    23761 tgtgtttgcg cgcacgtgaa acgaaggttc cttttccttg ttggcggaca atatagccat
    23821 ctttggcaag gtcgtttaag gcgcgaacaa ctgtgataga gctgacatcg tacattgaaa
    23881 tgagttctgc ttcagtgtaa aatttatctc cactgctaaa ctgcccagag atgattttat
    23941 tttttaattc gtcttttatg tattgatatt tgggaattgc catattttta cctctatttt
    24001 ccttctccat agaaaatttt accataaaag cgaaaaaaat agtagtcttt tgaataaaaa
    24061 attagaataa tagtttgaaa aattaagcga tatagggatt gctcatattt tataaatgta
    24121 ttctatacaa aattatttta ggtcctatat tccgaattta aagagcgttt gaaatgggtc
    24181 taaaaatgtt tgaaactaat tgaatgtgtg tataatagta aaaatgcagt aaatatcccg
    24241 acaatttcta ttgacaattc aaacagattg gtttataatt aatataacaa caaatgaaag
    24301 cgcaaacttt cgcggtcgga aggtagtttt atgacacgat ttgagatacg agatgatttc
    24361 tatctcgatg gaaaatcatt taagatttta tctggtgcca ttcattattt tagggttcct
    24421 ccagaggatt ggtatcattc gctctataac ttgaaggctc ttggttttaa tacggtagag
    24481 acttatgttg cttggaattt acacgagcct cgtgaaggtg agtttcattt tgacggtgat
    24541 ctggatttag agaaatttct ccaaatagcg caggatttgg gtctctacgc aattgtgcgt
    24601 ccgtctccat ttatctgtgc ggaatgggaa ttcggtggct taccagcttg gctcttgacc
    24661 aagaacatgc gaattcgctc atccgaccca gcatatatcg aggcagttgg tcgctactat
    24721 gatcagttat tgccaagact ggttcctcgt ttgttggaca atggtggcaa tattctcatg
    24781 atgcaggttg aaaatgagta tggttcttac ggagaagata aggcttacct gagagcgatt
    24841 cgacagctaa tggaagagtg tggcgtaacc tgtcccctct ttacatcaga tggtccatgg
    24901 cgagctactc tgaaagctgg aaccttaatt gaagaggacc tctttgtaac aggaaacttt
    24961 ggttctaagg caccttacaa cttttcgcag atgcaggaat tctttgatga acatggtaag
    25021 aaatggccac tcatgtgtat ggagttctgg gatggttggt ttaatcgttg gaaagaaccg
    25081 attatcacac gggatcctaa ggaattggca gatgcagttc gagaagtttt ggaacaaggc
    25141 tccatcaatc tttacatgtt ccacggtggt acaaactttg gtttcatgaa tggttgctcg
    25201 gctcgaggaa ctttggacct gccacaagtt acgtcttatg attacgatgc ccttctggat
    25261 gaagaaggaa atccaactgc taaatatctt gcagtcaaga agatgatggc aacacatttt
    25321 tcagagtatc cgcagttgga accactctac aaagagagta tggagttgga tgctattcca
    25381 ctagttgaaa aagtttcttt gtttgaaacc ttagatagct tgtcaagtcc tgtagaaagt
    25441 ctctatcctc aaaagatgga ggagctggga caaagttatg gctacctact ttatcgaaca
    25501 gaaacaaact gggatgcaga agaagaaaga cttcgtatca ttgatggtcg agatagggcc
    25561 cagctgtatg tcgatggtca gtgggttaaa actcaatatc agacagagat tggggaagat
    25621 attttttatc aaggtaaaaa gaaagggcta tctaggttag atatcttgat agaaaatatg
    25681 gggcgtgtca actatgggca taagttctta gcggatacgc aacgtaaggg aattcggaca
    25741 ggggtctgta aggatctgca tttcttacta aactggaaac actatccact cccactagac
    25801 aatcctgaga aaattgattt ttcaaaagga tggactcaag gacaaccagc cttttacgct
    25861 tatgacttta cagtcgaaga gccaaaagat acttacctag acttgtctga gtttggtaag
    25921 ggggttgcct ttgtcaatgg gcagaatcta ggacgttttt ggaacgttgg cccaactctc
    25981 tcactttata tccctcatag ctatctcaag gaaggtgcca accgcatcat tatctttgaa
    26041 acagaaggtc aatataaaga agagattcat ttaactcgta aacctacact aaaacatata
    26101 aagggggaaa acttatgaca attgtaggat gccgtattga tggacgtttg atccacggac
    26161 aagtagccaa tctttgggct ggaaaactaa atgtttcacg cattatggtt gtagacgacg
    26221 aagttgtcaa caacgatatt gaaaagagtg gtttgaaact tgcgacacca ccaggtgtga
    26281 aattgagtat tttgccagtt gagaaagctg cagccaatat tcttgctggc aaatacgata
    26341 gccaacgtct ctttatcgtg gctcgtaaac cagaccgctt ccttggtttg gtagaagcag
    26401 gtgtaccact tgaaaccctt aatgttggga atatgtctca aacaccagaa actcgttcta
    26461 ttacacgttc tatcaacgta gtagacaagg atgtggaaga cttccacaaa ctggcagaaa
    26521 aaggtgttaa acttactgct cagatggttc caaatgatcc aatttcagac tttttgagct
    26581 tattaaaata ggaaaaaatt ttttaggagg tcattgttat gatacaatgg tggcaaattt
    26641 tacttctcac tttgtactca gcttatcaaa tctgtgatga gttgacgatc gtttcatctg
    26701 caggttcccc tgtatttgct ggtttcatta ctggtttaat catgggagat gtgactactg
    26761 gtttacttat cggtggtaac ttgcaactgt tcgttcttgg ggttggtacc ttcggtggtg
    26821 cttctcgtat cgacgcaact tctggtgcgg ttcttgcgac agccttctct gtttcacaag
    26881 gaattgatgc accgcttgca attactacaa tcgctgtacc agtagcagct ctcttgactt
    26941 acttcgacgt tcttggtcgt atgactacta ccttcttcgc tcaccgtgtg gatgctgcaa
    27001 tcgaacgctt tgactataaa ggtattgaac gcaactactt gcttggtgcg attccgtggg
    27061 ctctatctcg tgcccttcca gtcttctttg cccttgcttt tggtggtgcc tttgtacaat
    27121 cagtagtaga cttcgttgaa gcctacaaat gggttgcaga tggcttgaca ctcgcaggac
    27181 gtatgcttcc aggtcttgga tttgcaatct tgcttcgtta ccttccagtt aaacgtaacc
    27241 ttcactacct tgctatggga tttggtttga cagctatgtt gactgttctt tactcatatg
    27301 taacaggtct tggtggcgct gttgctggta tcgtaggtac tcttcctgct gaagttgctg
    27361 aaaaaattgg tttcgtgaac aacttcaaag gtttgtctat gattggtatt tctatcgtag
    27421 gtattttcct tgcagtgctt cacttcaaaa atagccaaaa agtagctgta gcagcacctt
    27481 ctacaccatc agaaagtggg gaaatcgaag atgacgaatt ctaattacaa acttacaaaa
    27541 gaagatttta atcaaatcaa caaacgtagc ttgtttactt tccaattagg ttggaactac
    27601 gaacgtatgc aagcttctgg ttacctttac atgatcttgc ctcagttgcg taaaatgtat
    27661 ggtgatggaa ctcctgaatt gaaagaaatg atgaaagttc atactcaatt cttcaatact
    27721 tcaccattct tccataccat tatcgctggt tttgaccttg ccatggaaga aaaagatggt
    27781 gtaggttcaa aagacgctgt taacggtatc aagacaggtt tgatgggacc attcgctcct
    27841 cttggggata caatctttgg ttcacttgta cctgctatca tggggtcagt cgcagcaact
    27901 atggctatcg ctggccaacc ttgggggatc ttcctttgga ttgcagttgc agtagcgtat
    27961 gacatcttcc gttggaaaca gttggaattt gcttacaaag aaggggttaa ccttatcaac
    28021 aacatgcaaa gtaccttgac agctttgatt gacgctgcat ctgtacttgg tgtcttcatg
    28081 atgggtgctc ttgtagcaac agtgattaac tttgaaattt cttacaagtt gccaatcggt
    28141 gaaaagatga ttgatttcca agacatcttg aaccaaatct tcccacgttt gcttccagca
    28201 atctttactg cctttatctt ctggttgctt ggtaaaaaag gtatgaactc tactaaagct
    28261 atcggtatta ttatcgtact tgctttggct ctttctgccc ttggtcactt tgcacttgga
    28321 atgtaattcc ttatgactaa atcattaatt ttggtgagcc atggtcgctt ctgtgaggag
    28381 cttagaggta gcacagaaat gattatgggc ccacaagaca acatttacac agtagctctt
    28441 cttccagaag atggcccaga agaatttact gctaaatttg aagctgttat tgaaggattg
    28501 gatgatttcc tagtctttgc ggatcttctc ggtgggacac cttgtaatgt ggtgagtcgc
    28561 ttgatcatgg aaggtcgtga tattgacctt tacgcaggga tgaatcttcc aatggtgatt
    28621 gaatttatca atgcgagcct tacaggcgca gatgcggact acaagagccg tgctgcagaa
    28681 agcattgtga aagttaatga cctgttagcg ggcttcgatg atgacgaaga tgaataatac
    28741 tcttcgaaaa tctcttcaaa ctacgtcaac gtcgccttgc cgtaggtata tgttactgac
    28801 ttcgtcagtc ttatccggca acctcaaagc ggtgctttga gcagcctgcg gctagtttcc
    28861 tacagatttt agttggaact cgattcaatt catgtgacaa cgtgaaaatc gttagagcat
    28921 tttatataga atatacatgg gaatggagct tactcccatt cccatattta atagaaaaag
    28981 aggaactcaa tgctacatta tacaaaagaa gacttgctcg aattgggtgc agaaatcact
    29041 acgcgtgaaa tctaccaaca gcctgatgta tggagagaag cttttgaatt ttatcaagca
    29101 aaacgtgaag aaattgcagc ctttctacaa gaaatcgctg ataaacatga ctatattaag
    29161 gttatcttga caggtgctgg gacttctgct tatgtgggag ataccttgct accttacttt
    29221 aaggaagtct atgacgaacg caaatggaat ttcaatgcta ttgcgacaac agatatcgtt
    29281 gccaaaccag caacctattt gaaaaaagat gtggcaactg tccttgtgtc ttttgctcgt
    29341 agtgggaact cgcctgaaag tgtggcgact gttgatttgg ccaaatcctt ggtggatgag
    29401 ctttatcaag tgacgattac ttgtgcagca gatggtaaat tggctcttca agctcacggt
    29461 gatgaccgta atctcttgct cttgcaacca gctgtctcta atgatgctgg atttgccatg
    29521 acttctagct ttacgtctat gatgttgaca gctctcttgg tctttgatcc tacagaattt
    29581 gctgttaagt ctgaacgttt tgaagttgta tctagtcttg cccgtaaagt tttagacaag
    29641 gtagaagatg tcaaagagct cgttgattta gactttaacc gtgtcatcta tctaggcgct
    29701 ggtcctttct ttggacttgc tcatgaagct cagctcaaga ttttggaatt aactgctggt
    29761 caagttgcga ccatgtatga aagcccagtt ggcttccgtc acggtccaaa atctcttatc
    29821 aacgacaata cagttgtttt ggtctttggt acaacgacag cctacactcg taagtacgac
    29881 ttggacttgg ttcgtgaagt tgctggtgac cagattgctc gtcgtgttgt gcttttgagt
    29941 gatcaagctt ttggtcttga aaatgtcaaa gaagtggtcc ttggttgtgg cggtgtcttg
    30001 aatgatattt accgtgtctt cccttacatc gtttatgccc aactctttgc tctattgact
    30061 tcactcaagg tagaaaataa accagataca ccgtctccta caggtacagt aaaccgtgta
    30121 gtacaaggtg tcataattca cgaatatcaa aagtaagaca gtgtttatga attcttgaca
    30181 agaggatttg taaattatca gataaaccat agattgtcag tacgctttct atggtttgtt
    30241 tgcttgagag aaatagtaaa aggagaacag aatgaaagca tacacagagc gtgtatttgg
    30301 aaatgttgag ggcgaggatg tcttggccta tcgatttgag acagacggtg gctaccaact
    30361 tgaggttatg acttatggcg cgaccatctt gcgctatgtc gcacctgaca aggctggaaa
    30421 ttttgccaat gttatcttgg gatttgatga ctttgatagt tatgtaggca atagtcccaa
    30481 gcatggagca agtgtaggtc ctgtagcggg tcgtattgca ggtgcgacct ttgagctcaa
    30541 tggtaagacc tatgaccttg aggttaataa tgctagcaac tgtaatcaca gtggttcaac
    30601 tggttgggat tccagcttgt ttgaagttga agaagtaagc gatcatggct tgactctcta
    30661 cacagagcgt acagatggga caggagggtt ccctggaaat ctcaagattt ggatcagtta
    30721 tcacttggaa gaaactggtg cctatgaaat catctacaag gtaacgaccg atcaggatac
    30781 gctggtcaat ccaaccaacc acagctattt caacttgtct ggtgatttca cgcagacgat
    30841 tgaccgtcat gtcttccaac taaacacaga gggcatttac tcaatcgctc ctgacggtgt
    30901 tcctgccaaa actccagaag ccaaccgtga tgtggtcaaa cacatctaca atggtacctt
    30961 gttgaaggat atctttgcag aagaagatga gcaaatccag ctggcatcag gtttggatca
    31021 cccatttgcc cttcctgcag gccatgacaa tgctggattc ctttatgacc aaaattcagg
    31081 tcgcttcctg cttttcaaga cagaagctcc ttgctttgtg gtctacacag caaactttgt
    31141 ggatgaaagt gtcatcatag gaggtcagcc aatgctacag cacaatggga ttgctcttga
    31201 agcgcaagct ttaccagatg ccattcacag tgaccttaaa ggccaagtca ttcttaaagc
    31261 tggtcaaacc ttcaccagta agacacgtta tgaacttgtt gtgaaataaa aaaagctggt
    31321 caaaaagtct ttaaaattaa aataacgcat attgtcaggt gatgaaaagt ttgataatat
    31381 gcgttttatt atgaaatgat ttactttatc ttatcctgaa atggtgttat ttttgagtta
    31441 tctggcttga ctttcttgat ggaaattata taatagttgt aataacaata attacaacga
    31501 gaaaagagga ccatttatga cctatgaata caagagtcac atttatttgg cagagacagt
    31561 tttaaatgta aaggatttgg ccagtcaaac agccttttat cagcaagtta ttggtttaga
    31621 aatcttatct caaactgaga cagagtccat tctaggcctt ggtggaaaag tcttggtaca
    31681 gctgattcaa gcacaagaga gcggagaagt gagggaacat tatggtcttt accatttggc
    31741 cattctcttg cccacacgca aggctttggc tgatgtcttg aaacacctga cagatttgca
    31801 aattcctctt gtcggcggtg cagaccatgg ttacagtgaa gctatttact tggaagattt
    31861 ggagggaaat ggcattgaac tctatcgaga taagccagtt tccacatgga atattcgaga
    31921 agatggacgc attatcggag tgacggaggc tcttgcggcg caggacattt atgagttggg
    31981 ggaaagagta gagcccttta tcctggcaga aggtacaaga atggggcata ttcatctttc
    32041 cgtcaaggat agtcgaaagt ccagccagtt ttatcaaaag gtgttagggc tagagaataa
    32101 attcagtgtg cctggcgcta gttggattgc ggctggagat taccatcatc atttagcagt
    32161 taacgaatgg ggaggaaaag gtctggcttc gcgtaagcaa ggcttaccag gtttagccta
    32221 ctatgtcatc gaagtcgcac ataaaaaaga actgttaacg attgcccaac gagcacaaga
    32281 agttgacgca ccaatcaaat ggatgacatc gatccaattg gaaatcacag actcagatgg
    32341 catcgtgacc cgtattcgtt tagcaaggta aaattaggaa tttttaataa gttataagta
    32401 ttgctagttt gctttttgaa cggtctttgg taacagaact gcgtgagctg gatgggtgag
    32461 aattttgaca aagaagctga ttagagatat aatgaagaaa aatcgagcaa ggaaaaagaa
    32521 atgacaaatt caaagtatat tacttgtttg aaacgttcag agggccagtt gtgtgggatt
    32581 caaaagatga ttgaaggaga ttgtgactgt gctgatattg tgacgcaact gacagcagtg
    32641 agatctagtg tagagcgcgt gattgagatg ataattaccg aaaatcttac tgaatgtatc
    32701 aatcagccac tagatgattc tgaagctcaa aaggaacgcc tagaaaaggc tatccgatac
    32761 ttgattaaac ggaaataaat gaatgttttg agacgatatg tgcaaaggtc tattaactat
    32821 tagaatagtt taatgtgagt caaaagaagt tgtaaaaaat ctttaaaatt aaaaaaacgc
    32881 atagtatcag gtgttgaatg tattgacccc aaaaagttag attttttctg tctaactttt
    32941 ggggtgcagt tcataagaac cttggtaata tgcgttttat tatgtagaga cttatactct
    33001 tcgaaaatct cttcaaacca cgtcagcttc accttgccgt agatatggtt actgacttcg
    33061 tcagttctat ccacaacctc aaaacagtgt tttgagctga cttcgtcagt tctatccaca
    33121 acctcaaaac agtgttttga gctgacttcg tcagttctat ccacaacctc aaaacagtgt
    33181 tttgagctga cttcgtcagt tccatccaca acct
//
LOCUS       DAVLHC010000020        33026 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.020, whole genome shotgun sequence.
ACCESSION   DAVLHC010000020 DAVLHC010000000
VERSION     DAVLHC010000020.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 33026)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 33026)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..33026
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.020"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            119..2011
                     /gene="pepO"
                     /locus_tag="VXE25_001066"
     CDS             119..2011
                     /gene="pepO"
                     /locus_tag="VXE25_001066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000199272.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endopeptidase PepO"
                     /protein_id="HEV0771542.1"
                     /translation="MTRYQDDFYDAINGEWQQTAEIPADKSQTGGFVDLDQEIEDLML
                     ATTDKWLAGEEVPEDAILENFVKYHRLVRDFDKREADGITPVLPLLKEFQELETFADF
                     TAKLAEFELAGKPNFLPFGVSPDFMDARINVLWASAPSTILPDTTYYAEEHPQREELL
                     TLWKESSANLLKAYDFSDEEIEDLLEKRLELDRRVAAVVLSNEERSEYAKLYHPYSYE
                     DFKKFAPALPLDDFFKAVIGQLPDKVIVDEERFWQAAEQFYSEEAWSLLKATLILSVV
                     NLSTSYLTEDIRVLSGAYSRALSGVPEAKDKVKAAYHLAQEPFKQALGLWYAREKFSP
                     EAKADVEKKVATMIDVYKERLLKNDWLTPETCKQAIVKLNVIKPYIGYPEELPARYKD
                     KVVNETASLFENALAFARVEIKHSWSKWNQPVDYKEWGMPAHMVNAYYNPQKNLIVFP
                     AAILQAPFYDLHQSSSANYGGIGAVIAHEISHAFDTNGASFDENGSLKDWWTESDYAA
                     FKEKTQKVIDQFDGQDSYGATINGKLTVSENVADLGGIAAALEAAKREADFSAEEFFY
                     NFGRIWRMKGRPEFMKLLASVDVHAPAKLRVNVQVPNFDDFFTTYDVKEGDGMWRSPE
                     ERVIIW"
     gene            complement(2134..2763)
                     /locus_tag="VXE25_001067"
     CDS             complement(2134..2763)
                     /locus_tag="VXE25_001067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HEV0771543.1"
                     /translation="MKIHKTVNPVAYENTYYLEGEKHLIVVDPGSHWEAIRQTIEKIN
                     KPICAILLTHAHYDHIMSLDLVRETFGNPPVYIAESEASWLYTPVDNLSGLPRHDDMA
                     DVVTKPAEHTFVFHEEYQLEEFRFKVLPTPGHSIGGVSLVFPDAYLVLTGDALFRETI
                     GRTDLPTGSMEQLLHSIQTQLFTLPNYDVYPGHGPATTIAHEKAFNPFF"
     gene            3720..5942
                     /locus_tag="VXE25_001068"
     CDS             3720..5942
                     /locus_tag="VXE25_001068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019316080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional (p)ppGpp
                     synthetase/guanosine-3',5'-bis(diphosphate)
                     3'-pyrophosphohydrolase"
                     /protein_id="HEV0771544.1"
                     /translation="MPKEVNLTGEEVVALTKEYLTEEDVHFVHKALVYAVECHSGQYR
                     KSGEPYIIHPIQVAGILAKLKLDAVTVACGFLHDVVEDTDATLDDLEREFGPDVRMIV
                     DGVTKLGKVEYKSIEEQLAENHRKMLMAMSEDIRVILVKLSDRLHNMRTLKHLRKDKQ
                     ERISKETMEIYAPLAHRLGISSVKWELEDLSFRYLNPTEFYKITHMMKEKRREREALV
                     DEVVTKLEEYTTERHLKGKIYGRPKHIYSIFRKMQDKRKRFEEIYDLIAIRCILDTQS
                     DVYAMLGYVHEFWKPMPGRFKDYIANRKANGYQSIHTTVYGPKGPIEFQIRTKEMHEV
                     AEYGVAAHWAYKKGIKGQVNSKESAIGMNWIKEMMELQDQADDAKEFVDSVKENYLAE
                     EIYVFTPDGAVRSLPKDSGPIDFAYEIHTKVGEKATGAKVNGRMVPLTTKLKTGDQVE
                     IIANPNSFGPSRDWLNMVKTSKARNKIRQFFKNQDKELSVNKGREMLMAQFQENGYVA
                     NKFMDKRHMDQVLQKTSYKTEDSLFAAIGFGEIGAITVFNRLTEKERREEERAKAKAE
                     AEELVKGGEVKVENKETLKVKHEGGVVIEGASGLLVRIAKCCNPVPGDDIVGYITKGR
                     GVAIHRVDCMNLRAQENYEQRLLDVEWEDQYSSSNKEYMAHIDIYGLNRTGLLNDVLQ
                     VLSNTTKNISTVNAQPTKDMKFANIHVSFGIANLSTLTTVVDKIKSVPEVYSVKRTNG
                     "
     gene            5972..6415
                     /locus_tag="VXE25_001069"
     CDS             5972..6415
                     /locus_tag="VXE25_001069"
                     /EC_number="3.1.1.96"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-tyrosyl-tRNA(Tyr) deacylase"
                     /protein_id="HEV0771545.1"
                     /translation="MKIIIQRVKKAQVSIEGQIQGKINQGLLLLVGVGPEDQEEDLDY
                     AVRKLVNMRIFSDAEGKMNLSVKDIEGEILSISQFTLFADTKKGNRPAFTGAAKPDMA
                     SDFYDAFNQKLAQEVPVQTGIFGADMQVELVNNGPVTIILDTKKR"
     gene            complement(6652..6868)
                     /locus_tag="VXE25_001070"
                     /pseudo
     CDS             complement(6652..6868)
                     /locus_tag="VXE25_001070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000720032.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(7032..7682)
                     /locus_tag="VXE25_001071"
     CDS             complement(7032..7682)
                     /locus_tag="VXE25_001071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000188500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-dependent transcriptional regulator"
                     /protein_id="HEV0771546.1"
                     /translation="MTPNKEDYLKCIYEIGIDLHKITNKEIAARMQVSPPAVTEMIKR
                     MKSENLILKDKECGYLLTDLGLKLVSELYRKHRLIEVFLVHHLDYTSDQIHEEAEVLE
                     HTVSDLFVERLDKLLGFPKTCPHGGTIPAKGELLVEINNLPLADIKEAGAYRLTRVHD
                     SFDILHYLDKHSLHIGDQLQVKQFDGFSNTFTILSNDEDLQVNMDIAKQLYVEKIN"
     gene            7794..8636
                     /locus_tag="VXE25_001072"
     CDS             7794..8636
                     /locus_tag="VXE25_001072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase family protein"
                     /protein_id="HEV0771547.1"
                     /translation="MTKIALLSDIHGNTTALEAVLADAQQLGVDEYWLLGDILMPGTG
                     RRRILDLLDQLPITARVLGNWEDSLWHGVRKELDSTRPSQRYLLRQCQYVLEEISLEE
                     IEVLHNQPLQIHRQFGDLTVGISHHLPDKNWGRELIHTGKQEEFDRLVTHPPCDIAVY
                     GHIHQQLLRYGTGGQLIVNPGSIGQPFFLDAQLRKDLRAQYMILEFDDKGLVDMDFRR
                     VDYDVAAELQLAKDLRLPYFEVYYESLVNGIHHTHHQEFLRELAQKEGCDRELDDWLK
                     SGND"
     gene            8712..9149
                     /locus_tag="VXE25_001073"
     CDS             8712..9149
                     /locus_tag="VXE25_001073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004263219.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rrf2 family transcriptional regulator"
                     /protein_id="HEV0771548.1"
                     /translation="MQIPSRFTIATHMLIIIALEGKESKVTSDFLAASVGVNPVIIRN
                     ILSQLKKAELISVARGTGGTEIVKDLKDISLLDVYQAVECLGKTGQLFSFHDNPNPNC
                     PVGAHIHDVLDQKLERIQLTMEAELGQTSLEKVVADAESQMKD"
     gene            9217..9468
                     /locus_tag="VXE25_001074"
     CDS             9217..9468
                     /locus_tag="VXE25_001074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000281600.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771549.1"
                     /translation="MYLVIGIVLAFIVSFWKDNRSLWNPVLFLLSLISSYFYLSYLFY
                     KNGYENVQLAFYVFTFVLLPFLLFLSGIFLIYNGVILLK"
     gene            complement(9610..10683)
                     /locus_tag="VXE25_001075"
     CDS             complement(9610..10683)
                     /locus_tag="VXE25_001075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001273827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2974 domain-containing protein"
                     /protein_id="HEV0771550.1"
                     /translation="MANIFDYLKDVAYDSYYDLPLNELDILTLIEITYLSFDNLVSTL
                     PQRLLELAPQVPREPTMLTSKNRLQLLDELAQHKRFKNCKLSHFINDIDPELQKQFAA
                     MTYRVSLDTYLIVFRGTDDSIIGWKEDFHLTYMKEIPAQKHALRYLKNFFAHHPKQKV
                     ILAGHSKGGNLAIYAASQIEQSLQNQITAVYTFDAPGLHQELTQTAGYQRIMDRSKIF
                     IPQGSIIGMMLEIPAHQIIVQSTALGGIAQHDTFSWQIEDKHFVQLDKTNSDSQQVDT
                     TFKEWVATVPDEELQLYFDLFFGTILDAGISSINDLASLKALEYIHHLFVQAQSLTPE
                     ERETLGRLTQLLIDTRYQAWKNR"
     gene            10839..11516
                     /locus_tag="VXE25_001076"
     CDS             10839..11516
                     /locus_tag="VXE25_001076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548969.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEV0771551.1"
                     /translation="MHKILLVEDDQVIRQQVGKMLSEWGFEVVLVEDFMEVLSLFVQS
                     EPHLVLMDIGLPLFNGYHWCQEIRKISKVPIMFLSSRDQAMDIVMAINMGADDFVTKP
                     FDQQVLLAKVQGLLRRSYEFGRDESLLEYAGVILNTKSMDLHYQGQVLNLTKNEFQIL
                     RVLFEHAGNIVARDDLMRELWNSDFFIDDNTLSVNVARLRKKLEEQGLVGFIETKKGI
                     GYGLKHA"
     gene            11509..12483
                     /locus_tag="VXE25_001077"
     CDS             11509..12483
                     /locus_tag="VXE25_001077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397620.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HEV0771552.1"
                     /translation="MLDWKQFFLAYLRSRSRLFVYLLSLAFLVLLFQFLFASLGIYFL
                     YFFLLCCFVTILFFTWDILVEMQVYRQELLYGEREAKSPLEIALAEKLEAREMELYQQ
                     RSKAERKLTDLLDYYTLWVHQIKTPIAASQLLVAEVVDRQLKQQLEQEIFKIDSYTNL
                     VLQYLRLESFHDDLLLKQVQIEDLVKEIIRKYALFFIQKGLNVNLHDLDKEIVTDKKW
                     LLVVIEQIISNSLKYTKEGGLEIYMDDQELCIKDTGIGIKNSDVLRVFERGFSGYNGR
                     LTQQSSGLGLYLSKKISEELGHQIRIESEVGKGTTVRIQFAQVNLVLE"
     gene            complement(12532..14475)
                     /gene="thrS"
                     /locus_tag="VXE25_001078"
     CDS             complement(12532..14475)
                     /gene="thrS"
                     /locus_tag="VXE25_001078"
                     /EC_number="6.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000608363.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine--tRNA ligase"
                     /protein_id="HEV0771553.1"
                     /translation="MINITFPDGAVREFESGVTTFEIAQSISNSLAKKALAGKFNGKL
                     IDTTRAITEDGSIEIVTPDHEDALPILRHSAAHLFAQAARRLFPDIHLGVGPAIEDGF
                     YYDTDNTAGQISNEDLPRIEEEMQKIVKENFPSIREEVTKDEAREIFKNDPYKLELIE
                     EHSEDEGGLTIYRQGEYVDLCRGPHVPSTGRIQIFHLLHVAGAYWRGNSDNAMMQRIY
                     GTAWFDKKDLKNYLQMREEAKERDHRKLGKELDLFMISQEVGQGLPFWLPNGATIRRE
                     LERYIVNKELASGYQHVYTPPLASVELYKTSGHWDHYQEDMFPTMDMGDGEEFVLRPM
                     NCPHHIQVFKHHVHSYRELPIRIAEIGMMHRYEKSGALTGLQRVREMSLNDGHLFVTP
                     EQIQEEFQRALQLIIDVYEDFNLTDYRFRLSLRDPQDTHKYFDNDEMWENAQTMLRAA
                     LDEMGVDYFEAEGEAAFYGPKLDIQIKTALGKEETLSTIQLDFLLPERFDLKYIGADG
                     EDHRPVMIHRGVISTMERFTAILIENYKGAFPTWLAPHQVTLIPVSNEKHVDYAWEVA
                     KKLRDRGVRADVDERNEKMQFKIRASQTSKIPYQLIVGDKEMEDETVNVRRYGQKETQ
                     TVSVDNFVQAILADIANKSRVEK"
     gene            complement(14533..14709)
                     /locus_tag="VXE25_001079"
     CDS             complement(14533..14709)
                     /locus_tag="VXE25_001079"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MazG-like protein"
                     /protein_id="HEV0771554.1"
                     /translation="MTKQGRYYDETPYTLEQKLSENIWWLLELSQRLDIDILTEMKNF
                     LSDKEKQLNVRTRK"
     gene            complement(14716..14856)
                     /locus_tag="VXE25_001080"
     CDS             complement(14716..14856)
                     /locus_tag="VXE25_001080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000422774.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MazG-like protein"
                     /protein_id="HEV0771555.1"
                     /translation="MELQELVERSWAIRQAYHELEVKHHDFKWTVEEDLLALSNDIGN
                     FQ"
     gene            15726..16355
                     /locus_tag="VXE25_001081"
     CDS             15726..16355
                     /locus_tag="VXE25_001081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398308.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="HEV0771556.1"
                     /translation="MKLAVIAANGQAGKAIVEEAVKRGHEVTAIVRSENKSQAESIIK
                     KDLFELTKDDLTGFDAVISAFGAYTPDTLPLHSKSIELFNQLLAGTQTRFLVVGGAGS
                     LYIDETKTTRLLDTSDFPEEFKSLAKAQADELDLLRTKNNLNWTFVSPAVDFIPDGEK
                     TGNYILAGEIFTTNGKGISQISYADYAIGLVDELEKGHHIKERISLLEK"
     gene            16496..16765
                     /gene="rpsO"
                     /locus_tag="VXE25_001082"
     CDS             16496..16765
                     /gene="rpsO"
                     /locus_tag="VXE25_001082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001018251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S15"
                     /protein_id="HEV0771557.1"
                     /translation="MAISKEKKNEIIAQYARHEGDTGSVEVQVAVLTWEINHLNEHIK
                     QHKKDHATYRGLMKKIGRRRNLLAYLRKNDVNRYRELINSLGLRR"
     gene            17579..18193
                     /locus_tag="VXE25_001083"
     CDS             17579..18193
                     /locus_tag="VXE25_001083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000531723.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CadD family cadmium resistance transporter"
                     /protein_id="HEV0771558.1"
                     /translation="MGQTIISAIGVYISTSIDYLIILIILFAQLSQNKQKWHIYAGQY
                     LGTGLLVGASLVAAYVVNFVPEEWMVGLLGLIPIYLGIRFAIVGEDAEEEEEEIIERL
                     EQSKANQLFWTVTLLTIASGGDNLGIYIPYFASLDWSQTLVALLVFVIGIIIFCEISR
                     VLSSIPLIFETIEKYERIIVPLVFILLGLYIMYENGTIETFLIV"
     gene            complement(18485..19234)
                     /locus_tag="VXE25_001084"
     CDS             complement(18485..19234)
                     /locus_tag="VXE25_001084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000500208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="HEV0771559.1"
                     /translation="MFYTYLRGLVVLLLWSINGNAHYHNTNKIPNQDENYILVAPHRT
                     WWDPVYMAFATKPKQFIFMAKKELFTNRIFGWWIRMCGAFPIDRENPSASAIKYPINV
                     LKKSDRSLIMFPSGSRHSNDVKGGAALIAKMAKVRIMPVTYTGPMTLKGLISRERVDM
                     NFGNPIDISDIKKMNDEGIETVANRIQTEFQRLDEETKQWHNDKKPNPLWWFIRIPAL
                     ILAIILAILTIIFSFIASFIWNPDKKREELA"
     gene            19367..21703
                     /locus_tag="VXE25_001085"
     CDS             19367..21703
                     /locus_tag="VXE25_001085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000360031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation-translocating P-type ATPase"
                     /protein_id="HEV0771560.1"
                     /translation="MDKNKIMGLTQREVKERQAEGLVNDFTASASTSTWQIVKRNVFT
                     LFNALNFAIALALAFVQAWSNLVFFAVICFNAFSGIVTELRAKHMVDKLNLMTKEKVK
                     TIRDGQEVALNPEELVLGDVIRLSAGEQIPSDALVLEGFAEVNEAMLTGESDLVQKEV
                     DGLLLSGSFLASGSVLSQVHHVGADNYAAKLMLEAKTVKPINSRIMKSLDKLAGFTGK
                     IIIPFGLALLLEALLLKGLPLKSSVVNSSTALLGMLPKGIALLTITSLLTAVIKLGLK
                     KVLVQEMYSVETLARVDMLCLDKTGTITQGKMQVEAVLPLTETYGEEAIASILTSYMA
                     HSEDKNPTAQAIRQRFVGDVAYPMISNLPFSSDRKWGAMELEGLGTVFLGAPEMLLDS
                     EVPEAREALERGSRVLVLALSQEKLDHHKPQKPSDIQALALLEILDPIREGAAETLDY
                     LRSQEVGLKIISGDNPVTVSSIAQKAGFADYHSYVDCSKITDEELMAMAEETAIFGRV
                     SPHQKKLIIQTLKKAGHTTAMTGDGVNDILALREADCSIVMAEGDPATRQIANLVLLN
                     SDFNDVPEILFEGRRVVNNIAHIAPIFLIKTIYSFLLAVICIASALLGRSEWILIFPF
                     IPIQITMIDQFVEGFPPFVLTFERNIKPVEPNFLRRSMLRALPSALMVVFGVLFVKIF
                     GTSQGWSELEISTLLYYLLGSIGFLSVFRACMPFTLWRVLLIVWSVGGFLATALFSRI
                     QKLLEIATLTGQTLPVYGVMMLVFTVIFILTSRYQAKK"
     gene            21805..22482
                     /locus_tag="VXE25_001086"
     CDS             21805..22482
                     /locus_tag="VXE25_001086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000624068.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (adenine-N(1))-methyltransferase"
                     /protein_id="HEV0771561.1"
                     /translation="MISKRLELVASFVSQGAILLDVGSDHAYLPIELVERGQIKSAIA
                     GEVVEGPYQSAVKNVEAHGLKEKIQVRLANGLAAFEETDQVSVITIAGMGGCLIARIL
                     EEGLGKLANVERLILQPNNREDDLRIWLQNHGFQIVAESILEEAGKFYEILVVEAGQM
                     KLSASDVRFGPFLSKEVSPVFVQKWQKEAEKLEFALGQIPEKNLEERQVLVDKIQAIK
                     EVLHVSK"
     gene            22469..23266
                     /locus_tag="VXE25_001087"
     CDS             22469..23266
                     /locus_tag="VXE25_001087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000881127.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Nif3-like dinuclear metal center hexameric
                     protein"
                     /protein_id="HEV0771562.1"
                     /translation="MLASEVIQAYEAFCPQEFSMEGDSRGLQIGTLDKGIQRVMVALD
                     IREETVAEAIEKGVDLIIVKHAPIFRPIKDLLASRPQNQIYIDLIKHDIAVYVSHTNI
                     DIVENGLNDWFCQMLGIEETTYLQETGPERGIGRIGNIQPQTFWELAQQVKQVFDLDS
                     LRMVHYQENDLQKPISRVAICGGSGQSFYKDALAKGADVYITGDIYYHTAQDMLSDGL
                     LALDPGHYIEVLFVEKIAALLTQWKEKKGWELEILPSQASTNPFRHI"
     gene            23283..24386
                     /locus_tag="VXE25_001088"
     CDS             23283..24386
                     /locus_tag="VXE25_001088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-binding oxidoreductase"
                     /protein_id="HEV0771563.1"
                     /translation="MKKVAIIGAGIVGATAAYYLSRESDLEVTVFDHEQGQATKAAAG
                     IISPWFSKRRNKAWYKMARLGADFYVDLLADLEKSGQKIDFYQRSGVFLLKKDESKLE
                     ELYQLALQRREESPLIGQLAILDQASANELFPGLQGFDRLLYASGGARVDGQLLVTRL
                     LEASHVKLVKEKVTLTLLSSGYQIGEEVFDQVILATGAWLGDMLEPLGYEVDVRPQKG
                     QLRDYQLAQDMEDYPVVMPEGEWDLIPFAGGKLSLGATHENDMGFDLTVDEPLLQQME
                     EAALPHYPVLARATSRAERVGIRAYTSDFSPFFGQVPELAGVYVASGLGSSGLTTGPI
                     IGYHLAQLIQDKELTLDPLNYPIENYVKRVKSE"
     gene            24393..24539
                     /locus_tag="VXE25_001089"
     CDS             24393..24539
                     /locus_tag="VXE25_001089"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771564.1"
                     /translation="MKIKEQTRKLAAGYSKHCFEVVYRTDEVSNHTHGKATLTWFELD
                     FRRV"
     gene            24642..25661
                     /gene="galE"
                     /locus_tag="VXE25_001090"
     CDS             24642..25661
                     /gene="galE"
                     /locus_tag="VXE25_001090"
                     /EC_number="5.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="HEV0771565.1"
                     /translation="MQEKILVTGGAGFIGTHTVIELIQAGHQVVVVDNLVNSNRKSLE
                     VVERITGVEIPFYEADIRDTVTLRDIFKQEEPTGVIHFAGLKAVGESTRIPLAYYDNN
                     IAGTVSLLKAMEENNCKNIIFSSSATVYGDPHTVPILEDFPLSVTNPYGRTKLMLEEI
                     LTDIYKADSEWNVVLLRYFNPIGAHESGDLGENPNGIPNNLLPYVTQVAVGKLEQVQV
                     FGDDYDTEDGTGVRDYIHVVDLAKGHVAALKKIQKGSGLNVYNLGTGKGYSVLEIIQN
                     MEKAVGRPIPYRIVERRPGDIAACYSDPAKAKAELGWEAELDITQMCEDAWRWQSKHP
                     NGFED"
     gene            25663..26616
                     /locus_tag="VXE25_001091"
     CDS             25663..26616
                     /locus_tag="VXE25_001091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931854.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HEV0771566.1"
                     /translation="MMISIIVPCLNEEEVLPLFYQALEALLPDLETEIEYVFVDDGSS
                     DGTLELLKAYREQNPAVHYISFSRNFGKEAALYAGLQYATGDLVVVMDADLQDPPSML
                     FEMKNVLDKNVDLDCVGTRRTSREGEPFFRSFCAVLFYRLMQKISPVALPSGVRDFRM
                     MRRSVVDAILSLTESNRFSKGLFAWVGFKTHYLDYPNVERQAGKTSWSFRQLFFYSIE
                     GIVNFSDFPLTIAFVAGLLSCFLSLLMTFFVVVRTLILGNPTSGWTSLMAVILFLGGI
                     QLLTIGILGKYISKIYLETKKRPLYLIKEKSDLPDFTEKIK"
     gene            complement(26678..26884)
                     /locus_tag="VXE25_001092"
     CDS             complement(26678..26884)
                     /locus_tag="VXE25_001092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001843159.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferredoxin"
                     /protein_id="HEV0771567.1"
                     /translation="MKITLIPERCIACGLCQTYSDLFDYHDNGIVRFYDDPDQLEKEI
                     SPSRDVLEAVKNCPTRALIGNQEA"
     gene            26936..27412
                     /locus_tag="VXE25_001093"
     CDS             26936..27412
                     /locus_tag="VXE25_001093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399345.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysM domain-containing protein"
                     /protein_id="HEV0771568.1"
                     /translation="MAKEPWQEDIYDQEESRAGRRHRNHGGADRMANRILTILASIFF
                     VIVVVMVIVLIYLSSGGSNRTAALKDFHDSDASVVQISSSSSSQPEQSSEPESTSSSS
                     EEAANPEGTIKVLAGEGEAAIAARAGISIAQLEALNPGHMATGSWFANPGDVIKIK"
     gene            27421..28092
                     /locus_tag="VXE25_001094"
     CDS             27421..28092
                     /locus_tag="VXE25_001094"
                     /EC_number="2.7.4.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000849376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="(d)CMP kinase"
                     /protein_id="HEV0771569.1"
                     /translation="MKTIQIAIDGPASSGKSTVAKIIAKDFGFTYLDTGAMYRAATYM
                     ALKNQLGVEEVEALLALLDQHPISFGRSETGDQLVFVGDVDITHPIRENEVTNHVSAI
                     AAIPEVREKLVSLQQEIAQQGGIVMDGRDIGTVVLPQAELKIFLVASVDERAERRYKE
                     NIAKGIETDLETLKKEIAARDYKDSHRETSPLKQAEDAVYLDTTGLNIQEVVEKIKAE
                     AEKRM"
     gene            28223..28561
                     /locus_tag="VXE25_001095"
     CDS             28223..28561
                     /locus_tag="VXE25_001095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002920966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alkylphosphonate utilization protein"
                     /protein_id="HEV0771570.1"
                     /translation="MNNLPNCPKCNSEYVYEDGALLVCPECAHEWNPAEVAEVEEGLV
                     AIDANGNKLADGDIVTLIKDLKVKGAPKDLKQGTRVKNIRIVEGDHNIDCKIDGFGAM
                     KLKSEFVRKI"
     gene            28564..29193
                     /locus_tag="VXE25_001096"
     CDS             28564..29193
                     /locus_tag="VXE25_001096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000033944.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Pr6Pr family membrane protein"
                     /protein_id="HEV0771571.1"
                     /translation="MSKHYKLVFYSRIFLFLAAFTGVYLEITRHGGFGMLLYYTVLSN
                     LLVTIFTLYLLKVMSRVGENWQRPSLLRLKGGVTMSIMITCVIYHFLLAPIATNFYTL
                     ENFLCHYIVPIWFLADTLFFDKQGQYKIWDPAVWTILPFLYMMFALFNGLVLKLNIPN
                     AKDNPFPYFFLNVNKGWNVVFKWCLIIFVAYMVAGFIFYFIKQIKRKSS"
     gene            29433..30584
                     /locus_tag="VXE25_001097"
     CDS             29433..30584
                     /locus_tag="VXE25_001097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000808687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEV0771572.1"
                     /translation="MKQFLERASILALSLVLITSFSISSALPAMFDYYQGYSKEQIEL
                     LVSLPSFGIMMMLLLNGFLEKIFPERLQISLGLLILSLSGTAPFWYQAYPFVFGTRLL
                     FGLGLGMINAKAISIISERYQGKRRIQMLGLRASAEVVGASLITLAVGQLLAFGWTAI
                     FLAYSAGFLVLPLYLLFVPYGKSKKEVKKRAKKASRLTREMKGLIFTLAIEAAVVVCT
                     NTAITIRIPSLMVERGLGDAQLSSFVLSIMQLIGIVAGVSFSFLISIFKEKLLLWSGI
                     TFGLGQIVIALSSSLWVVVAGSVLAGFAYSVVLTTVFQLVSERIPAKLLNQATSFAVL
                     GCSFGAFTTPFVLGAIGLLTHNGMLVFSILGGWLIVISIFVMYLLQKRA"
     gene            30897..31646
                     /gene="truA"
                     /locus_tag="VXE25_001098"
     CDS             30897..31646
                     /gene="truA"
                     /locus_tag="VXE25_001098"
                     /EC_number="5.4.99.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000199202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA pseudouridine(38-40) synthase TruA"
                     /protein_id="HEV0771573.1"
                     /translation="MTRYKATISYDGYAFAGFQRQPHARSVQEEIEKTLTRLNKGQTI
                     TVHGAGRTDSGVHALGQVIHFDLPYQMDEEKLRFALDTQSPEDIDVISIELVADDFHC
                     RYAKHSKTYEFIVDRGRPKNPMRRHYATHFPYPLDVERMQIAIKKLEGTHDFTGFTAS
                     GTSVEDKVRTITEASLIVDETGQFLTFTFSGNGFLYKQIRNMVGTLLKIGNNRMPVEQ
                     IALILEKKDRQLAGPTAAPNGLYLKEIRYEE"
     gene            31636..32409
                     /locus_tag="VXE25_001099"
     CDS             31636..32409
                     /locus_tag="VXE25_001099"
                     /EC_number="2.7.4.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional hydroxymethylpyrimidine
                     kinase/phosphomethylpyrimidine kinase"
                     /protein_id="HEV0771574.1"
                     /translation="MKNNRILALSGNDIFSGGGLSADLATYTLNGLHGFVAVTCLTAL
                     TEKGFEVFPTDDTIFQHELDSLRDVEFGGIKIGLLPTVSVAEKALDFIKQRPGVPVVL
                     DPVLVCKETHDVAVSELCQELIRFFPYVSVITPNLPEAELLSGQEIKTLEDMKTAAQK
                     LHDLGAPAVIIKGGNRLSQDKAVDVFYDGQTFTILENPVIQGQNAGAGCTFASSIASH
                     LVKGDKLLPAVESSKAFVYRAIAQADQYGVRQYEANKNN"
     gene            32387..32848
                     /locus_tag="VXE25_001100"
     CDS             32387..32848
                     /locus_tag="VXE25_001100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000814967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HEV0771575.1"
                     /translation="MKQTKTTKIALVSLLTALSVVLGYFLKFPTPTGILTLLDAGVFF
                     AAFYFGSREGAVVGGLASFLIDLLSGYPQWMFFSLVNHGLQGFFAGFKGKSQWLGLIL
                     ATIAMVGGYALGSTLMNGWAAALPEILPNFMQNMVGMIVGFILSQSIKKIK"
BASE COUNT         9409 a         6238 c         7625 g         9754 t
ORIGIN      
        1 ttttatcatg gaaaggtttt ttataatagc taaaaaataa tagttaaatg gttattaatt
       61 gcattcccta gtgatttttg ttaagataaa ggcaaataca aatgaaagcg agaacaagat
      121 gacacgttat caagatgatt tttatgatgc tatcaatgga gaatggcaac agacagctga
      181 aatcccagca gataagtctc aaacaggagg ttttgttgat ttagaccagg aaattgaaga
      241 cctgatgctg gcgacaacag acaagtggtt agcaggtgaa gaagtgcctg aggatgctat
      301 cttggaaaac tttgtcaaat accaccgcct agttcgtgat tttgacaaga gagaagctga
      361 cggtatcaca cctgtcttac cactccttaa agaattccaa gaattggaaa cttttgcgga
      421 ttttacagct aaactagcag agtttgagct tgcaggaaaa ccaaacttcc ttccttttgg
      481 tgtatcgcca gactttatgg atgctagaat caatgttcta tgggctagcg ctccaagcac
      541 aatcttgcca gatacgacct actatgcaga agaacatcct cagcgcgaag agctcttgac
      601 tctttggaaa gaaagtagcg caaatctcct caaggcttat gatttctctg atgaagaaat
      661 tgaagacttg ctagaaaaaa gacttgaatt ggaccgccga gttgcggcag tggtgctctc
      721 taatgaagaa cgttcagaat atgctaaact ctatcatcca tattcttacg aagatttcaa
      781 gaaattcgcg cctgccctac ctttggatga cttcttcaaa gcagttattg ggcaattacc
      841 agacaaggtt attgtagacg aggaacgttt ctggcaagca gcagagcaat tttacagtga
      901 ggaagcctgg tctctcctta aagcaacctt gattttgagt gttgtcaatc tttcaaccag
      961 ctatttaaca gaggatatcc gtgttttgtc tggtgcctac agccgtgccc tttctggagt
     1021 tccagaggca aaagataagg tcaaagcagc ttatcatcta gcacaggaac ctttcaagca
     1081 agccctgggg ctttggtacg cccgtgagaa gttctctcca gaagccaagg cggatgtgga
     1141 gaaaaaagtg gcaaccatga ttgatgtcta taaggagcgt ctgcttaaga atgactggct
     1201 cactccagaa acctgtaaac aggctatcgt gaagctcaat gtgatcaaac cttatattgg
     1261 ctatccagaa gaattgcctg cacgttacaa ggataaggta gtgaatgaaa ctgccagtct
     1321 ttttgagaat gctctagcct ttgcgcgtgt ggaaatcaag cacagttgga gtaagtggaa
     1381 ccagcctgta gactataagg aatggggcat gcctgctcat atggtcaatg cctactacaa
     1441 tcctcagaag aacctgattg tctttccagc ggccatttta caggcgcctt tctatgactt
     1501 gcatcagtca tcttctgcta actacggtgg tattggggca gtgattgccc atgaaatttc
     1561 ccacgccttt gatactaacg gggcttcctt tgacgaaaat ggtagcctca aggattggtg
     1621 gacagagagc gactatgctg ccttcaagga gaaaacacaa aaagtcattg accaatttga
     1681 tggacaggat tcttatggag caaccattaa cggtaaattg actgtatcag aaaacgtggc
     1741 tgacttggga ggaatcgcag cagctcttga agcagctaag agagaagcag acttctcagc
     1801 agaagagttc ttctacaact tcggtcgcat ctggcgcatg aaaggtcgac cagaatttat
     1861 gaaacttttg gctagcgtcg atgtgcacgc accagccaaa ctccgtgtca atgtgcaagt
     1921 accaaacttc gacgatttct ttacaaccta tgatgtcaaa gaaggagacg gaatgtggcg
     1981 ttcaccagag gagcgcgtga ttatttggta atgcaaaaaa tctagtcatc agaaaaaagg
     2041 catccaatca cgtgtgaaaa ccttgatagg atgcctttta taatagaaag atttgctgga
     2101 tagtttactt aaatttcgat tgtcatcatc ttgctaaaaa aagggattga aggctttttc
     2161 gtgagcgata gtagtagctg gaccatgtcc tggatagaca tcgtagtttg gtagggtgaa
     2221 gagttgggtc tggatactat gaaggagttg ctccatgcta ccagtcggaa ggtcggtccg
     2281 tccgatagtt tcgcggaata gagcatctcc cgtcaagact aggtaagcat caggaaagac
     2341 tagggaaaca ccaccgatag agtgccctgg ggtcggtaga accttaaaac gaaattcctc
     2401 tagttggtat tcttcgtgaa agacaaaggt gtgttctgca ggttttgtga ccacatctgc
     2461 catatcatcg tggcgaggga gaccggagag attatcgaca ggagtgtaga gccagctggc
     2521 ttcgctctct gcgatataga caggaggatt gccaaacgtc tcgcgaacca agtccagact
     2581 catgatatgg tcataatggg cgtgggtcaa gagaatagca cagatcggtt tgttgatctt
     2641 ctcgattgtc tgacgaatgg cttcccaatg actaccagga tcgacgacga tgaggtgctt
     2701 ttcgccttct agataatagg tattttcata ggcaacagga ttcacggttt tatggatttt
     2761 catactagct ccaatctcaa agaatgtact aatactcttc gaaaatctct tcaaaccgcg
     2821 tcaactttat ctgcaacctc aaagcagtgc tttgaacagc ctgcggctag ctttctagtt
     2881 tgctctttga ttttcattga gtataaatta agtatagcac agttagggag aataggtaag
     2941 gatttaaaat gaacttaaaa atcagcatga ctagatgaag acaggctggt tatcaattta
     3001 tcaatattgg aaaggtgtca attgcccttc ataggttgca taaactccgt cattagcttg
     3061 tttgatagac gtgatgttta gagtgctacc gtagttggct tctcatttgt cgctatattc
     3121 actataagtt atcctactgg gcaggttctg gtcgttagca tagtattgaa cgagtttttt
     3181 atagctttgc tggctgaata ggaacaggca gcaaactcct aacattagga gagcaaagat
     3241 agaaatagca gtttttttca taggtattct ccttataaac taaaggatag aagaaagtat
     3301 cttgaggatt tttatactct tcaaaaatct cttcaaaccg cgtcaacttt atctgcaact
     3361 tcaaagcggt gctttgagta acctgcggct agtttcctag tttgctcttt gattttcatt
     3421 tagtattaat tccaaaatcc agtcaaggta ccagtgtatg tgctacgagt tccaccgttt
     3481 atctttcgta ttttcaatgg aattggggaa gtcagaaagt ctttgggtta caatatggtt
     3541 tccgttcttc tatctctcct tctatcacct aagtttaaaa tctaacttcg tagtatatta
     3601 tgggctaata attcagaatt atcaagcaat tttgaattat ttttttctta ttctgttcca
     3661 atctagtttt catattctta aaaaagtgat aaaatggtag gaagaattgg agagtagaga
     3721 tgccgaaaga agtgaattta acaggcgaag aagttgtcgc tttaaccaaa gaatatttaa
     3781 cggaagagga tgttcatttt gtccataagg ccttggtcta tgctgttgaa tgccacagtg
     3841 gtcaatatcg caaatcaggc gagccttata tcattcaccc tatccaagtg gcaggtattt
     3901 tagctaagct aaagctggat gctgtaacag tagcttgtgg attcttgcat gatgtggtgg
     3961 aagatacaga tgcgactttg gacgatttgg aaagagagtt tggtcctgat gtgcggatga
     4021 ttgttgacgg agttaccaag cttggcaagg tcgagtacaa atcgatcgag gagcaattag
     4081 cggaaaatca tcgcaagatg ctcatggcca tgtctgagga catccgcgtt attttggtca
     4141 aactgtctga ccgcttgcac aatatgcgga ccctgaaaca tcttcgaaaa gacaagcagg
     4201 agcgtatttc caaagaaacc atggaaatct atgccccact tgcccatcgt ttggggattt
     4261 ccagtgtcaa atgggaatta gaagacttgt ctttccgtta tctcaatcca acggagtttt
     4321 acaagattac ccatatgatg aaggaaaagc gcagggagcg tgaggccttg gtggatgagg
     4381 tagtcacaaa attagaggag tatacgacag aacgtcactt gaaagggaag atttatggtc
     4441 gtcccaagca tatttactca attttccgca aaatgcagga caagagaaaa cggtttgagg
     4501 aaatctatga tctgattgct attcgttgta ttttagatac ccaaagtgat gtttatgcca
     4561 tgcttggtta cgtgcatgaa ttttggaaac cgatgccagg tcgcttcaaa gactatattg
     4621 ccaaccgcaa ggccaatggt tatcagtcta tccatacgac tgtttatgga ccaaaagggc
     4681 cgattgaatt ccagattcga accaaggaaa tgcacgaggt ggctgagtac ggggttgcgg
     4741 ctcactgggc ttataagaaa ggtataaagg ggcaagttaa cagcaaggaa tcagctattg
     4801 gaatgaactg gatcaaggag atgatggagc tccaagacca ggctgatgat gctaaggaat
     4861 ttgtggactc tgttaaggaa aactatttgg ctgaggagat ttacgttttt accccagatg
     4921 gagctgtccg ttcccttccc aaagattcag gaccgattga ttttgcctac gaaatccata
     4981 ccaaggtcgg tgaaaaagca actggtgcca aggtcaatgg ccgcatggtt ccactgacaa
     5041 ccaagttaaa gacaggggat caggttgaaa ttatcgccaa cccgaactcc tttggaccta
     5101 gccgtgactg gctcaatatg gtcaagacta gcaaggcgcg caataagatt cgccagttct
     5161 ttaaaaacca agataaggaa ttgtctgtca acaagggtcg tgagatgctg atggctcagt
     5221 tccaagaaaa tggctatgtg gcaaataaat ttatggacaa gcgccacatg gatcaagttc
     5281 tgcaaaagac cagttacaag acagaagact ccctctttgc ggccattggt tttggggaaa
     5341 tcggtgcgat taccgtcttt aaccgtctga ctgaaaagga acgccgtgag gaagagcgtg
     5401 ccaaggccaa ggctgaggca gaggagcttg tcaaaggtgg cgaggtcaag gttgaaaata
     5461 aagaaactct caaggtcaag catgaggggg gagtggttat tgaaggtgct tctggtctcc
     5521 tagtgcggat tgctaagtgt tgtaaccccg tgcctggtga cgatattgtt ggctacatta
     5581 ccaagggtcg tggtgtggct attcaccgtg tggactgtat gaacctgcgt gcccaagaaa
     5641 actacgagca acgtctcctt gatgtggaat gggaagacca gtactctagc tcaaataagg
     5701 agtatatggc ccatatcgat atctacggtc tcaaccgtac aggactgttg aacgatgtac
     5761 tgcaagttct ttcaaataca accaagaata tttcaacggt caatgcccaa ccaaccaagg
     5821 atatgaagtt tgctaatatc catgtgtcct tcggtattgc caacctctct acactgacca
     5881 cggttgtcga taaaattaag agtgtgccag aagtttactc tgtcaaacgg accaacggct
     5941 agttgtccta gctcttacta gaaaggctat tatgaaaatc attatccaac gggttaaaaa
     6001 agcccaagtg agtatagaag gccagattca gggaaaaatc aatcagggac ttttattgct
     6061 ggttggtgtt ggaccagagg accaagagga agatttggac tatgctgtga gaaaactggt
     6121 caatatgcgg attttttcag acgcagaagg caagatgaac ctgtctgtca aagatattga
     6181 aggagaaatc ctctctattt ctcagtttac cctctttgcg gatactaaga aaggcaatcg
     6241 tccagccttt acaggggcag ctaaacctga tatggcatca gacttctatg atgctttcaa
     6301 tcaaaaatta gcgcaagaag tgcccgttca gacaggtatc tttggagcag atatgcaggt
     6361 tgagctggtt aataacggac ctgttaccat tatcctagat actaaaaaga gataagaaag
     6421 accaagccca gtcggcttgg tctttctcat cgatcataaa atactccaaa aagaaatcgg
     6481 ttcttgatat gcttggggga agtctctttt caggctttgg cagatgcgat aggaagggat
     6541 gagatgtcct aggatgagga gagttccctg aaggaaaagt ggaatatcac ttaaagacac
     6601 caaggagaga atcatcaggc tatcccatag gagaatttgt aaagcaaaac gtcagaatct
     6661 cggtctaatc tgggaataga gttgactaaa gtggtcacaa agttggtttg aaagataggt
     6721 caatagcaca ggatgaaaga aaatgagcca accactataa atcaaaatcc agtcccaagt
     6781 aagcccccct tttaaatgtc aaaaatgcca gcatgattcc atcaatgaca aggagttgaa
     6841 tggttttgat gaagatgatt tttttcatgc taaaacctcc ttttttcatc tgttagtgac
     6901 gtaatgcttt atataattat tatacagtat tcagtcggga tatgaaaacg tttactatcg
     6961 tttttgatat aaaaaataga taagaaaacc ctgaaaataa aactttcagg gttggtaggg
     7021 gacttgagaa attagttgat tttctcgaca tagagttgtt ttgcaatgtc catattcact
     7081 tgtaaatcct cgtcgttact gaggatagtg aaggtattgc tgaagccatc aaactgcttg
     7141 acttggagct ggtcaccgat gtgaagtgag tgcttgtcca gataatggag aatgtcaaaa
     7201 ctatcgtgca cccgagtcag gcggtaggcg ccagcttcct tgatatcagc tagtgggagg
     7261 ttattgattt caacgaggag ttctcccttg gcaggaatag ttcctccgtg ggggcaggtt
     7321 ttagggaaac ctagcagttt atctagtctt tccacgaaca ggtcagagac agtgtgttcc
     7381 aagacctcag cttcctcgtg aatctggtca cttgtatagt ctaaatgatg aactagaaaa
     7441 acttcaatca agcggtgctt acgatagagc tcagagacca gtttgagacc gaggtcagtc
     7501 agtagatagc cacattcctt gtcctttagg atgagatttt cacttttcat tcgtttgatc
     7561 atttcagtta cggcaggggg agagacttgc atgcgagccg caatttcctt gttggtaatc
     7621 ttatgcaggt ctatgccaat ttcataaata cattttagat agtcttcttt gtttggggtc
     7681 attcgtttcc tcttgtctaa tatctttatc tagtatatca aaaaaagcta gatttctcta
     7741 gctgtgactt tttatgttat acttattgca agagaaaaaa cgaggagatg gatatgacga
     7801 aaatagctct tctttcagat attcatggaa ataccaccgc cttggaggct gttttggcag
     7861 atgctcagca gctaggagtg gatgaatact ggcttttggg agatattctc atgccaggga
     7921 caggacgtag aaggattttg gacttgttgg atcaactacc gattacggct agagttttgg
     7981 gaaactggga agacagtctt tggcatggtg tccgtaagga attggacagt actcgcccca
     8041 gtcaacgcta tctcttgcgc cagtgccagt atgttttaga ggaaatttcc ctagaagaaa
     8101 ttgaagtgct ccacaatcaa cctcttcaaa ttcatcgtca gtttggggat ttgacggtgg
     8161 gaattagcca tcatctgcct gataagaact gggggcgaga gttgattcat actggcaaac
     8221 aagaggagtt tgaccgcttg gtgactcatc ctccctgtga tattgctgtt tatggacata
     8281 ttcaccagca gttgcttcgt tacgggactg gtgggcaatt gattgtcaat ccgggttcga
     8341 ttggccaacc tttctttttg gacgctcagc tacggaagga cttgcgggcc cagtatatga
     8401 ttttggagtt tgatgacaag ggtctggtag atatggactt ccgacgggta gactacgatg
     8461 tggcagcgga attgcagctg gctaaagacc tgagacttcc ctattttgag gtttactatg
     8521 aaagtctggt caatgggatc caccatactc atcatcagga atttttgaga gaattggctc
     8581 agaaagaggg ctgcgatcgg gagttagacg actggttgaa aagtggtaac gattgacatt
     8641 acaactaaaa agggtataat aatagaaaaa gaagagtaga ggcagggtag cctcgtaaaa
     8701 aggagaagag gatgcaaatt ccaagtagat ttaccattgc gactcatatg ctgataatca
     8761 ttgccctcga ggggaaggaa agcaaggtga ccagtgattt tctggctgct agtgtcgggg
     8821 tcaatcctgt cattatcaga aatatcttgt cccagttgaa gaaggcagag ctgatttcag
     8881 tagcgcgtgg aacgggcgga acagagattg tcaaggacct taaggatatt agtcttttag
     8941 atgtttatca ggcggtcgaa tgtcttggta agacaggtca actcttcagt ttccatgaca
     9001 atccgaatcc aaattgccct gtaggagctc atattcatga tgttttggat caaaaattgg
     9061 agagaattca gttgactatg gaggcagaac ttggtcaaac cagtctagaa aaagtcgtgg
     9121 ccgatgcaga gagtcagatg aaggattaag agggataaat gccctctttt ttctttggat
     9181 aattatgata aaatgtagct attaaaggag taagaaatgt atctcgttat aggaattgta
     9241 ttagccttta tagtgtcatt ttggaaggat aatagaagtt tgtggaatcc agtattattt
     9301 ttattatccc tcatttcaag ttatttttat ctatcctacc ttttttataa aaatggatac
     9361 gagaatgttc agttagcttt ttatgtattt acctttgtct tacttccttt tttgcttttt
     9421 ctaagtggca tctttttaat ctataatggg gtcattttgt tgaagtgaga gggacgttcc
     9481 aagccccatt atctctcaat gctctttgat ttttattgac tattagattc tatttaaaaa
     9541 gacttagaat gcacatgaaa gtatgtattc taggtctttt gttttgtata catttaattt
     9601 tcaagagtat tatctatttt tccatgcctg gtaacgagta tcaatcaata actgggtaag
     9661 gcgacccaag gtttctcttt cttctggagt gagggattga gcttggacaa agagatgatg
     9721 aatgtattca agcgccttta aggaagccaa gtcgttgata gagctaatac cagcatcaag
     9781 aatagtgcca aagaagaggt cgaagtagag ctgaagttct tcgtcaggga ctgtggccac
     9841 ccattcttta aaggttgtgt ctacttgctg gctatcactg ttggtcttat ccagttggac
     9901 gaagtgcttg tcctcaatct gccaactaaa ggtatcgtgc tgggcgatgc cacccagggc
     9961 agtactctga acgatgattt ggtgagcagg aatttccagc atcataccga taatggaacc
    10021 ttgtggaatg aatatcttgc ttctatccat tatcctttga taacccgcag tctgtgtcaa
    10081 ttcttgatgg agaccaggtg catcaaatgt ataaactgct gtgatctgat tttgcaaact
    10141 ttgctcaatt tggctagcag catagatagc gagatttcct cccttggaat gcccagccag
    10201 aataaccttt tgcttaggat gatgggcaaa aaagttcttt aaatagcgaa gggcgtgctt
    10261 ttgagcagga atttccttca tataggtcag gtggaaatct tccttccagc caatgatact
    10321 gtcatctgtc ccacgaaaga caatcagata ggtatcgagg ctgacacgat aagtcatagc
    10381 cgcaaattgc ttttgcagtt cagggtcgat gtcgttgata aaatgggaga gtttgcaatt
    10441 tttgaagcgc ttgtgttgag ccaattcatc taataattga aggcgatttt tgctagtaag
    10501 catggtgggc tctcttggaa cctgaggtgc tagctctaaa agacgttgag gaagtgtgga
    10561 gaccagatta tcaaaggaga ggtaggtgat ttctattaag gttagaatgt ctaactcatt
    10621 caagggaagg tcgtaataag aatcatatgc gacatctttc agatagtcaa aaatattggc
    10681 cataagagct cctttctttt tatttatctt agcaaatttc cctcaaatta gctagtagca
    10741 ttgcctgttt gtactggcta aaaacaggct atttcaaatt cagtttcaga ccatctggca
    10801 tggaaaaatc tgttataata atggaaaagg agaagcgcat gcacaagatt ttattagtgg
    10861 aagatgatca ggtcattcgt caacaggttg ggaaaatgct ctctgaatgg ggatttgaag
    10921 tggtcctggt agaagacttt atggaagttt tgagtctatt tgttcagtcg gaacctcatc
    10981 tggtcctcat ggatattggt ttgcccttgt ttaatggtta tcactggtgt caggaaatcc
    11041 gcaagatttc caaggtacct atcatgtttc tttcttcgag agaccaggct atggatattg
    11101 tcatggcaat caatatgggg gcggatgact ttgtgaccaa gccttttgac cagcaggttc
    11161 ttttagctaa ggttcagggc ttgttgcgtc gttcctatga gtttgggcgt gatgagagtt
    11221 tgctggaata tgctggtgtt atcctcaata ccaaatccat ggatttacat tatcaagggc
    11281 aagtcttgaa tttgaccaag aacgaattcc agattttacg cgtgttattt gagcatgcag
    11341 gcaacatcgt agcacgtgac gacctgatgc gagaactttg gaacagtgac tttttcattg
    11401 atgataatac cctctctgtc aatgtggctc gtttgcgtaa aaagttggag gagcagggat
    11461 tggtaggatt tatcgagacc aagaaaggaa tagggtacgg attgaagcat gcttgattgg
    11521 aaacaatttt ttctagccta tctgcgctcc cgtagtcgtc tttttgtcta tctgctttct
    11581 ttggcatttc tggtcttact ctttcagttt ttatttgcca gtctaggaat ttacttcctc
    11641 tactttttcc tcttgtgttg ctttgtaacc atcttatttt tcacttggga catattggtg
    11701 gaaatgcagg tttatcgcca ggaacttctc tatggagaga gggaagccaa gtctcctttg
    11761 gaaatagctt tagcagaaaa attagaagcg cgtgagatgg aactctatca gcagaggtca
    11821 aaagcagaaa gaaaactgac ggatttgctg gattactata ccttgtgggt ccatcagata
    11881 aagaccccca ttgcagccag tcaactctta gttgcagaag tggtcgaccg ccaactgaag
    11941 cagcagctag aacaggaaat tttcaaaatc gactcctata ccaacctagt tttacagtac
    12001 ctgcgtttag aaagtttcca tgatgatttg ctcttaaagc aggttcaaat tgaggacttg
    12061 gtcaaggaaa taattcgtaa atatgctctt ttctttattc aaaaaggctt aaatgtcaat
    12121 ctacatgacc ttgataaaga aatcgtgacg gataaaaagt ggctgctagt ggttattgag
    12181 caaatcatct caaacagtct caagtacacc aaggaaggtg gtctggagat ttatatggat
    12241 gaccaagagc tttgtatcaa agatacggga atcgggataa aaaacagtga tgtcctccga
    12301 gtatttgaac gtggcttttc aggatacaat ggccgtttga cccagcagtc ctctggactt
    12361 ggcctttatc tatctaagaa aatttctgaa gaactggggc accagattcg tatcgagtct
    12421 gaggtcggaa aaggaacgac agtgcggatt cagtttgctc aagtgaactt agtccttgag
    12481 taaaaataga tgagaaaaag cctccagatt ggaggctttt atgctagact cttatttctc
    12541 aacgcgtgat ttgttggcga tatcagctag gatagcttga acaaaattat caactgagac
    12601 agtttgtgtt tctttttggc cgtagcgacg aacgttgact gtttcgtctt ccatttcttt
    12661 gtctccaaca attaattggt aaggaatctt gctggtttgt gaagcacgga tcttgaactg
    12721 cattttttca ttgcgctcat ctacatctgc acggacaccg cggtcacgga gtttcttggc
    12781 cacttcccaa gcgtagtcca cgtgtttttc gttagatact gggatgaggg ttacttggtg
    12841 tggtgccagc catgttggga aggccccctt gtagttctca atcaagatag ctgtgaagcg
    12901 ttccatagtt gagataactc cacggtggat catgactgga cggtgatctt cgccatcagc
    12961 tccgatgtat ttgaggtcga agcgttctgg caacaagaaa tcaagttgga tagtagaaag
    13021 ggtttcttct tttccaaggg cagttttaat ctggatatcc aattttggtc cgtagaaggc
    13081 tgcttcacct tcggcttcaa agtagtccac gcccatttca tcaagagctg cacgaagcat
    13141 ggtttgggca ttttcccaca tctcatcgtt atcaaagtac ttatgagtat cttgagggtc
    13201 acgaagagag aggcggaagc ggtagtcagt caagttgaag tcttcataaa catcgataat
    13261 caactgaagg gcacgttgga attcttcttg gatttgttct ggagtaacga ataggtgacc
    13321 gtcgttgagt gacatttcac gtacacgttg aaggccagtg agggcaccag atttttcgta
    13381 acggtgcatc ataccgattt cagcgatacg gattggcaat tcacggtaag agtgaacatg
    13441 gtgtttaaaa acttggatgt ggtgcggaca gttcattgga cgaaggacaa attcttcccc
    13501 gtcacccatg tccatggttg ggaacatgtc ttcttggtaa tgatcccagt gaccagaagt
    13561 cttgtaaagc tcaacagaag caagtggtgg agtgtagacg tgttggtagc cagaagccaa
    13621 ctctttgttt acgatgtagc gttccaattc acgacggata gtcgcaccat ttggcaacca
    13681 gaatggcaaa ccttgtccca cttcttgtga aatcataaag aggtcaagct ctttaccaag
    13741 tttacggtgg tcacgttcct tagcttcttc acgcatttga aggtagtttt tcaagtcttt
    13801 cttgtcaaac caagctgtac cgtagatacg ttgcatcata gcgttgtcgc tgtttccacg
    13861 ccagtacgca ccagctacat ggagaaggtg gaagatttgg atacgacctg ttgatggaac
    13921 gtgaggtcca cggcagaggt ctacatattc accctgacga tagatagtca aaccgccttc
    13981 gtcttctgag tgttcttcaa tcaattccaa cttgtaaggg tcatttttga agatttcacg
    14041 tgcctcgtct ttagtcactt cttcacgaat agatgggaag ttttctttga cgattttttg
    14101 catttcttct tcgatacgag gaaggtcttc gttagagatt tgaccagctg tgttgtcagt
    14161 atcgtagtag aaaccatctt cgatggctgg accaactccc aagtgaatgt ctgggaaaag
    14221 acgacgagct gcttgggcga acaagtgagc tgctgagtga cgcaagattg gaagggcatc
    14281 ttcgtgatca ggtgtcacaa tttcgatgct tccatcttca gtgatagcgc gagtagtgtc
    14341 gatgagtttg ccgttgaatt taccagccaa ggctttttta gctagggaat tgctgataga
    14401 ttgggcaatt tcaaaagttg ttacgccaga ttcgaattca cgaacagcgc catctgggaa
    14461 agtaatgtta atcatgatgt tctccttttt tattatttca tagtttctaa gcattgattt
    14521 tttatcagca gactacttcc gagtcctaac gttcaattgc ttttctttat cagagaggaa
    14581 gtttttcatt tccgtcagaa tgtctatatc caaacgttga gaaagttcta atagccacca
    14641 gatattttct gaaagttttt gttccagtgt gtagggtgtt tcatcatagt agcgtccttg
    14701 ctttgtcatc accagtcatt ggaaatttcc aatatcatta gataaagcca agaggtcttc
    14761 ttctaccgtc cacttgaaat catgatgctt aacttccagt tcgtgataag cttgtcggat
    14821 tgcccaactg cgctccacta attcttgcaa ctccataatt agtatcctaa taaaaaaatg
    14881 cgacatcctc gaaaggacgt cgcaacgtgg ttccaccttc atttatgtac ctcaaaagag
    14941 agggacacct ctgatcggct ctaacgtggc caccgtttta tgttttcata aaaaactcaa
    15001 gagtagtatc agtttagact tcctatgcgt ttccagcaac cacgcactct ctagtagaaa
    15061 gggactaagt gacttgtctc tatggattat tatagcatga ttgtgagatt tttcaaggat
    15121 tttgtgaaag ttttttgttt ttcatttttt gtagaatatg cttgatgcta ataccagaat
    15181 ccatgccgac cagagcaact gtttcataga ttagcaagta aattagtata aactcaccaa
    15241 aggttatgat agtaaagtaa aagagcagtc cgttaccaac taaccatcaa agtgagaaac
    15301 ggaaacggta gctatagagt aacgatataa tcaagattac cagaggtgta aagaagagaa
    15361 gattgtttat atagagttcc ttgagtgtaa gggggtcaga aacaactagt aagaacaact
    15421 cataaagtgg ccaataaaag aataatatga ccagatagta ggggagatgg gaatagaatc
    15481 tacgcatgat aatcacctcg ttttaaaaaa acagacaact tagatctctt gctatgatta
    15541 ttatagcatg tttaaaacaa gaaagtaaat ttgttgacaa agaagatttt tcttttcact
    15601 agaatcatag ttagttttct tggtagaaat attttgataa taattaagca agactattga
    15661 cattaattat taagagtgtc acaattgttg taactaaaat aattacaaca agagaggtat
    15721 aaaaaatgaa actagcagtt attgcagcaa atggacaagc ggggaaagca attgttgaag
    15781 aagcagtcaa acgaggacat gaagtaacgg ctattgttcg ttctgaaaac aaaagtcaag
    15841 ctgagtctat tattaaaaaa gatttatttg agttgacaaa agatgatctt actggatttg
    15901 atgctgttat ttcagcgttt ggtgcttata caccagatac gctaccgctc cacagcaaat
    15961 caatcgaact atttaatcag cttcttgctg gaacacagac acgttttcta gttgtagggg
    16021 gagcaggaag tctttatata gatgaaacaa aaacgacacg acttttagat acgtctgatt
    16081 ttcctgaaga atttaagtca ctagcaaaag ctcaagcgga tgaattggat cttcttcgta
    16141 caaaaaataa tctcaactgg acttttgtca gtcctgctgt agattttatt cccgatggtg
    16201 aaaaaacagg aaactacatt ctagcaggag aaatttttac tactaatgga aaaggaataa
    16261 gccagattag ttatgcagat tatgctattg gattggtaga tgaacttgaa aaaggtcatc
    16321 atataaaaga acgtatctct ttacttgaaa aataataact atgagagtat taatgtttga
    16381 cagaaaattt aaatcttggt aaaataagga ttgtcgtaaa gacaaataac ttcttcttgg
    16441 ttacaggcat gccaacctgt cactcggatg aagccaaata aaaaggagaa acatcatggc
    16501 aatctcaaaa gagaaaaaaa atgaaatcat tgcacaatat gcacgtcacg aaggtgatac
    16561 aggttcagta gaggttcaag ttgctgtcct tacttgggaa atcaatcacc ttaacgaaca
    16621 catcaaacaa cataaaaaag accacgctac ttaccgtgga ttgatgaaaa aaatcggtcg
    16681 ccgtcgtaac ttgcttgcat acttgcgtaa aaacgacgtt aaccgttacc gtgagttgat
    16741 caactctcta ggacttcgtc gctaattcaa gatacaaatg ctgtcaaaag cacaaagcaa
    16801 aaataggaaa attgacgaag aaacttcagt ttctaggaga ttttatcttt tttgccaagt
    16861 gcttaggccg tgttcaattg agcatatctt gataataaag ctactctaaa ttgggtagct
    16921 tttttgcgtt gtcaccttac ctcgatatac tcaagtataa tctttggtta cggttcctag
    16981 cactgtaagg taaaataaac cagcttttct cccttcgggg agattttttt gtttcactga
    17041 aagtttcgta cgatcttcgc ctcgtcgcct agtctataaa cgatttatct agcaagaatc
    17101 atgatgctaa gggcgtcaaa aatccgtatg aaaataggga aatgacacag tgttcgatga
    17161 gcacaaggag tttcatcttt ttcactagga ttttagcccg ggctcaaatc agctctctga
    17221 cttcagaggg cttttttatt gaggttttat cggtaacaat tttggagact acaaaaatct
    17281 caaacggtat cagctaatta caccataaag gtgcgcagtt actcggattt tcaagccgag
    17341 tagctgtatg caagccccct agaagagccc actctttaca aagtaaagta tagtatgtta
    17401 tactttacat ggaagtagtc actgaattcc agttagaaat tactttgtaa ctacgttttg
    17461 aggaggagta aaatgctttc ctacgttcga cattacccac tagcgatagc taaattaatg
    17521 tgtctgtgct ctcctaaaat ctgctgattt attactgact aatacaggag ttttttttat
    17581 gggacagaca atcatatctg ctattggtgt ttatatttcc accagtatcg attatttaat
    17641 tattttaatt attttatttg cacagctatc acagaataaa cagaaatggc atatttatgc
    17701 ggggcaatat ctaggcacag gcttacttgt aggggcgagt ttagttgctg cttatgtcgt
    17761 taatttcgtg cctgaagaat ggatggttgg attgcttggt ttaatcccta tctatttagg
    17821 gattcgcttt gcaattgttg gagaagatgc ggaagaagaa gaggaagaaa ttattgaaag
    17881 attagaacaa agcaaggcaa atcaactgtt ttggacagtt acattgctga caattgcgtc
    17941 tggcggagat aatttaggta tctatatacc ttattttgct tcgttagatt ggtcacagac
    18001 cctcgtggcc ttgcttgtgt ttgtaatcgg cataattatc ttttgcgaga ttagtcgggt
    18061 gttatcctct attccgttaa tattcgagac aattgaaaaa tacgagcgaa tcattgtgcc
    18121 cttagtattc attctacttg gactatacat catgtatgaa aatggcacga tagagacttt
    18181 tctgatcgtg tagatttttt tgtttcacta ggattttagt ccgagctcaa atcagctctc
    18241 tgattttcag agggcttttt cattgagtat aaatggacaa tcttaaagtt actctattgt
    18301 agagtggctt ttgatttgat taggagattc ttataaatat agtaaaatga aataagaata
    18361 ggacaaatcg atcaggacag tcaaatcgat ttctaaaaat gttttagaag tagaggtgta
    18421 ctattctagt tccaatctac tatataaatg aaaaccttag ctgtttcgcc aaggttcatt
    18481 tcttctatgc aagttcttct cttttcttat ctgggttcca gatgaagctt gcgataaagc
    18541 taaagatgat ggttaggata gcgaggataa tagcaaggat gagggcaggg atgcggataa
    18601 accaccagag tggatttggt tttttatcat tgtgccattg tttcgtttct tcgtccagac
    18661 gttggaattc tgtttgaata cgattggcga ctgtttcaat gccttcatca ttcattttct
    18721 tgatatctga gatatcgatt ggatttccaa agttcatatc gacacgttca cggctaatca
    18781 agcccttcaa agtcatggga ccggtgtagg taaccggcat gatacggacc ttggccattt
    18841 tggcaatcag tgctgcgccc cccttgacat cgtttgagtg gcggctacca cttggaaaca
    18901 tgatgagaga gcggtcactt tttttgagaa cgttgatagg atatttgatg gctgaggcgc
    18961 tgggattttc acggtcgatg ggaaaggcgc cacacatacg aatccaccaa ccaaagatac
    19021 ggttggtaaa gagttctttt tttgccataa agatgaactg ttttggcttg gtcgcaaagg
    19081 ccatataaac aggatcccac caggtacggt gaggcgcaac taaaatataa ttttcatctt
    19141 gattaggaat tttattagta ttatgatagt gagcattgcc attgatggac cataagagca
    19201 atacaactaa tccacgcaaa taagtataaa acatgcgatc tccttcgatt gttttcttgt
    19261 tattattata ccttatcaaa ggagggctgg caaacttttc ccttgactag atgcatattt
    19321 gggatgaaat tagaattctg ttaaaaaaaa tgatataata gaatttatgg ataaaaataa
    19381 gattatggga ttaacccaaa gagaagtcaa ggaaagacag gctgagggtt tggtcaatga
    19441 ctttaccgca tcagccagta ccagcacttg gcaaatcgtt aaacgaaatg tctttaccct
    19501 ttttaacgct ttgaactttg ccattgcttt ggctcttgcc tttgtgcagg cttggagcaa
    19561 tctggtcttc tttgctgtta tctgctttaa cgctttttct gggattgtga ccgagctacg
    19621 agccaaacac atggtggaca agctcaatct catgaccaag gaaaaggtca aaaccatccg
    19681 tgatggtcag gaagttgctc ttaatcctga agaattagtg ctaggagatg tcattcgttt
    19741 gtctgcagga gagcagattc ctagtgatgc cttggttttg gaaggctttg cggaagtcaa
    19801 tgaagccatg ttaacgggag aaagtgattt ggtgcaaaag gaagttgacg gcttactttt
    19861 gtcaggaagt ttcctagcca gtgggtcagt tttatctcaa gttcaccatg tcggtgcaga
    19921 caactatgct gccaaactca tgcttgaggc taagaccgtt aaacccatca actcccgtat
    19981 catgaaatcg ctggacaagt tggctggttt tactgggaag attatcattc cctttggtct
    20041 ggctctcttg ctggaagcct tgcttttaaa aggcctgcct ctcaagtcat ccgttgtaaa
    20101 ctcgtcgaca gctcttttgg gaatgttgcc taagggaatt gcccttttga ccattacttc
    20161 gctcttgact gcagtgatta agttgggctt gaaaaaggtc ttggtgcagg agatgtactc
    20221 tgttgagacc ttggcgcgcg tggatatgct ctgtctggac aagacgggca ccatcaccca
    20281 aggaaagatg caggtggagg ctgttcttcc actgacggaa acttacggtg aagaggctat
    20341 tgccagcatc ttgactagct acatggccca tagtgaggat aagaatccaa ctgcccaagc
    20401 cattcgccag cgttttgtgg gagatgttgc ttatcctatg atttccaatc ttcccttctc
    20461 gagcgaccgc aagtgggggg ctatggagtt agaaggcttg gggacagttt tcttaggggc
    20521 acctgagatg ttgctggatt ctgaagtccc agaagccagg gaggccttgg agagaggatc
    20581 acgtgtcttg gtcttagctc tcagtcagga gaaattagac catcacaaac cacagaaacc
    20641 atctgatatt caggctctag ccttgctgga aatcttggac cccattcgag agggagcagc
    20701 agagacgctg gactatctcc gttctcagga ggtgggactc aagattatct ctggtgacaa
    20761 tccagttacg gtgtccagca ttgcccagaa ggctggtttt gcggactatc acagctatgt
    20821 agattgctca aaaatcaccg atgaggaatt gatggccatg gcggaggaga cagctatttt
    20881 cggacgtgtt tcccctcatc aaaagaaact catcatccaa acgttgaaaa aagcgggtca
    20941 tacaacggct atgacagggg acggggttaa tgatatcttg gcccttcgtg aggcggattg
    21001 ttctatcgtg atggcggagg gggatccagc aacccgtcag attgccaatc tggttctctt
    21061 gaactcagac tttaatgatg ttcctgagat tctcttcgag ggtcgtcgcg tggtcaataa
    21121 cattgcccac atcgccccga ttttcttgat aaagaccatc tattccttcc tgttagcagt
    21181 catctgtatt gccagtgctt tactaggtcg gtcagagtgg attttgattt tccccttcat
    21241 tccgatccag attaccatga ttgaccagtt tgtggaaggt ttcccaccat tcgttctgac
    21301 ttttgagcga aatatcaaac ctgtcgagcc aaacttcctc agaagatcca tgcttcgtgc
    21361 cctaccaagt gccctcatgg tcgtgtttgg cgttcttttt gtgaaaatct ttggaacgag
    21421 tcaaggttgg tctgagttag aaatctcaac tctcctctat tatctcttgg ggtcaattgg
    21481 tttcttatcc gtatttagag cctgcatgcc attcactcta tggcgagtcc tattgattgt
    21541 ctggtcagta ggaggcttcc tagccacagc tctcttctca agaattcaaa aactgcttga
    21601 aattgcaacc ttaacaggac aaacattacc tgtttatggt gtcatgatgt tggtctttac
    21661 cgtgattttc atcctgacca gtcgttacca agcgaaaaaa taaagaaaga ctgcaatctg
    21721 tggattgcag tttttttagg tacaagattg ccagccgaaa tgtggtataa taagaggtaa
    21781 tagagttttg gaaagtgaga gaagatgatt tcaaagagat tagaattggt agcttccttt
    21841 gtgtcacagg gggctatttt actagatgtg ggaagtgacc atgcttatct gcctatcgag
    21901 ttggttgaga gaggccaaat caaaagcgct attgcaggtg aggtggtgga aggtccctat
    21961 cagtctgcgg ttaaaaatgt tgaggctcac ggcctaaagg agaaaatcca agtccgttta
    22021 gccaatggct tggcagcttt tgaagagact gaccaagtgt ctgtcattac cattgctggc
    22081 atgggtggtt gtttgattgc taggatttta gaagaaggtt tggggaagtt agctaatgta
    22141 gagcgtttga tcctccagcc caataatcgt gaagacgact tgcgtatctg gctacagaat
    22201 catggattcc agattgtagc agaaagcatc ttagaagaag ctggcaagtt ttacgagatt
    22261 ttggtggtgg aagcaggaca aatgaagcta tcagccagtg atgttcgctt tggtcccttc
    22321 ttgtccaaag aagtcagtcc agtatttgtc caaaaatggc aaaaagaagc tgagaagcta
    22381 gagtttgccc tcggacaaat cccagaaaaa aatctggagg aacgtcaagt tctagtagat
    22441 aagattcaag ctatcaagga ggtgctccat gttagcaagt gaagtgatcc aagcttatga
    22501 agccttttgc cctcaggaat tttctatgga gggagacagc cgtggtctgc aaattggcac
    22561 tttagacaag ggtatccaaa gggtcatggt tgccctcgat attcgtgaag agacggtggc
    22621 agaggccatt gaaaagggtg tggacttgat tatcgtcaag cacgcgccta tctttcgtcc
    22681 tatcaaggac ttgcttgcca gccgtccgca aaatcagatt tacatcgacc tgattaagca
    22741 tgacatcgca gtttatgtca gccataccaa tattgatatc gttgaaaatg ggctcaatga
    22801 ctggttttgt cagatgctag gaatcgagga gacgacttat ctgcaggaaa caggtccaga
    22861 acgtggaatt ggacgtattg ggaatattca gcctcagaca ttttgggaat tggcccaaca
    22921 ggtcaagcaa gtctttgacc tagatagcct tcgaatggtg cattatcaag agaatgattt
    22981 gcagaagcct atttcaagag tagcaatttg tggtggaagc gggcagtctt tctataagga
    23041 tgctttggca aagggggcag atgtctatat cactggtgat atctactacc atactgctca
    23101 ggatatgctg tctgatggct tgttagcatt ggatccaggt cactatatcg aagtgctttt
    23161 tgtggaaaaa atcgcagcac tccttactca atggaaagag aaaaaaggct gggaactaga
    23221 gattttacct agtcaagcat cgaccaatcc tttccgtcat atctagttag aaagtgaaga
    23281 caatgaaaaa agttgccatt attggagcag gaattgtggg agcaacagct gcctactacc
    23341 tctcgagaga aagtgaccta gaggtgaccg tttttgacca tgagcaaggt caagccacca
    23401 aggccgcagc aggaattatc agtccttggt tttccaaacg ccgtaataaa gcctggtaca
    23461 agatggcgcg cttgggggct gacttttatg tggatttatt agctgattta gagaaatcag
    23521 gacaaaaaat cgacttttac cagcgttcgg gagtctttct cttgaaaaag gatgaatcca
    23581 agttggaaga actttatcaa ctggccctcc agcgcagaga agaatctccc ttgatagggc
    23641 aattagccat tctggaccaa gcttcagcta atgaattatt ccctggtttg cagggatttg
    23701 accgcctgct ctatgcttct ggtggagcga gagtagatgg ccaactcttg gtaactcgtc
    23761 tgctagaagc cagtcatgtc aagctggtca aagaaaaagt gactctgaca ctcttatcat
    23821 caggctacca gattggcgaa gaggtgtttg atcaggttat tttggcaacg ggagcttggt
    23881 tgggggacat gttagagcct ttaggttatg aagtggatgt ccgtcctcaa aaaggacaac
    23941 tacgagatta tcagcttgcc caagacatgg aagattaccc tgttgtcatg ccagaagggg
    24001 agtgggattt gattcccttt gcaggtggga aattatcctt gggcgctacc catgaaaatg
    24061 acatgggatt tgatttgacg gtagatgaac ccttgctcca acaaatggag gaggcggcct
    24121 tgcctcatta cccagtttta gctagagcga cttcaagggc tgagcgtgtg ggaatccgtg
    24181 cctataccag tgatttctct cccttctttg ggcaggtgcc agaattggca ggtgtctatg
    24241 tagccagtgg actaggttca tcaggcctca caactggtcc tatcattggt taccatctag
    24301 cccaactgat ccaagacaag gagttgacct tggaccctct aaattatcca attgaaaact
    24361 atgtcaaacg agtaaaaagc gaataatact caatgaaaat caaagaacaa actaggaaac
    24421 tagccgcggg ttactcaaag cactgctttg aggttgtgta tagaactgac gaagtcagta
    24481 accataccca tggcaaggcg acgttgacgt ggtttgaatt ggattttcga agagtataag
    24541 cattttactg aaattttatc aggtagttta ggatggcaaa tgacattccc tgtcaaaaat
    24601 ggtaaaataa gaaaaaataa tctgagaatc gaggaaaaaa gatgcaagaa aagattttgg
    24661 taactggtgg tgccggtttt attggaaccc acactgttat tgaattgatc caagcaggcc
    24721 atcaagttgt tgtggtggat aatcttgtca atagcaatcg taagagttta gaagttgttg
    24781 aaagaatcac aggagttgag attcctttct atgaggcaga tattcgtgac acagttaccc
    24841 tcagagatat tttcaagcag gaagaaccga ctggtgtcat tcactttgct ggtttgaagg
    24901 ctgttggcga atcaacacgt atccctcttg cctactatga caacaatatc gctggaactg
    24961 tcagcctttt gaaagccatg gaagaaaaca actgtaaaaa catcatcttc agttcttctg
    25021 cgacagttta cggggatccg cacacagtgc ccatcttgga agatttccca ctttcagtga
    25081 ccaacccata cggtcgtacc aagctcatgc tagaggaaat tttgaccgat atttacaaag
    25141 cagactcaga atggaatgtt gtcttgcttc gttactttaa cccaatcgga gcccatgaga
    25201 gtggtgattt gggagaaaat ccaaacggta ttccaaacaa tctcttgcca tatgtgactc
    25261 aagtagccgt tggaaaatta gagcaagtgc aagtgtttgg agacgattac gatacggaag
    25321 atggaacagg tgttcgtgac tatatccacg ttgtcgattt ggctaagggt cacgttgcag
    25381 ctttgaaaaa aatccaaaaa ggttcaggac taaacgttta taaccttgga actggtaaag
    25441 gttactcagt tcttgaaatt atccaaaaca tggaaaaagc ggtgggacgt cctattcctt
    25501 accgcatcgt agaacgtcgc ccaggtgata tcgctgcctg ctactcagac ccagcaaaag
    25561 ctaaagcaga actcggttgg gaagcagaac tcgacatcac ccaaatgtgt gaagacgcat
    25621 ggcgttggca aagcaagcat ccaaatggat ttgaagacta agatgatgat ttcaatcatc
    25681 gtcccttgtt taaacgaaga ggaagtactt cctctttttt atcaggctct ggaagcttta
    25741 cttccagatt tggaaacaga aatcgagtat gtctttgtcg atgatggatc aagtgatggg
    25801 accttggaac tcttaaaggc ctatcgggag caaaatccgg cagtccatta tatttctttc
    25861 tctcgaaatt ttggcaaaga agcagccctt tatgcaggct tgcaatatgc gacaggagat
    25921 ttggtggtgg tgatggatgc agacctccaa gatcctccta gtatgttgtt tgagatgaaa
    25981 aatgtactag acaaaaatgt agacttggac tgcgttggga cacggagaac tagtcgggag
    26041 ggagaaccct tctttcgcag tttctgtgct gttctctttt atcgcctcat gcaaaaaatc
    26101 agcccagtag ctctgccgtc gggtgtccgt gactttcgta tgatgagaag gtctgtggtc
    26161 gatgccattt taagcttgac tgagtccaat cgtttttcta agggactctt tgcctgggtc
    26221 ggctttaaaa cccactatct ggactatcca aatgtcgaaa ggcaggctgg caagaccagt
    26281 tggagtttta ggcaactctt tttttactcc attgaaggga ttgttaattt ttcagatttc
    26341 cctttgacta tagcctttgt agctggtctc ctatcttgtt ttctttctct gctgatgacc
    26401 ttttttgttg tggttcggac cctcattttg ggcaatccga catctggttg gacctctctg
    26461 atggctgtta ttctctttct tggaggcatt caactcttga ccattgggat tctcggtaag
    26521 tatatcagta agatttattt agagactaaa aaaagaccac tttatcttat caaagaaaaa
    26581 agtgaccttc ctgattttac agaaaaaata aagtgaaaag actataattt tacatggaaa
    26641 tgtgctaaac tagagggagt ggattatcgc cattgattta ggcttcctgg tttccaatca
    26701 gggcgcgagt tgggcaattt ttaacagcct ctaagacatc ccgactagga gaaatttctt
    26761 tttccagttg gtcagggtca tcgtaaaaac gcacgattcc attatcgtgg taatcaaata
    26821 aatcagaata agtttggcaa agtccacagg cgatacatcg ttcaggtata agtgtgattt
    26881 tcatgttcat atttatattg taataagaaa agtaaaaaaa aacaaggagt aaggtatggc
    26941 aaaagaaccg tggcaagaag atatttatga tcaagaagaa tcaagagcag ggcgtcggca
    27001 tcgaaaccac ggaggggctg ataggatggc taatcgtatt ttgacgatcc tagctagtat
    27061 tttctttgta attgtggtgg tgatggtcat cgttctcatc tatctatcat cgggggggag
    27121 taatcgcaca gcagccttaa aagactttca tgattctgat gcaagtgtag tacaaatctc
    27181 atcttcaagc agttctcagc ctgagcagag ttcagagcca gaatctactt ctagtagttc
    27241 agaagaagct gctaatcctg aaggaacgat taaagttctc gcaggagaag gggaagcagc
    27301 tattgccgct cgtgcaggaa tctccattgc tcagttagag gccttgaatc ctgggcacat
    27361 ggctacagga tcttggtttg ctaatccagg tgatgttata aaaataaaat aggagccgat
    27421 atgaaaacaa ttcaaattgc tattgatggt cctgcttcca gcggtaagag tacggtcgca
    27481 aagattattg ctaaggattt tggattcacc taccttgata caggagctat gtatcgtgca
    27541 gcgacctata tggctcttaa gaaccaatta ggagttgaag aagtcgaagc ccttctagcc
    27601 ttgttggacc agcatccaat cagctttgga cgttcagaaa ctggagacca gcttgttttt
    27661 gtaggagatg tggatattac ccatcctatc cgtgaaaatg aagtgaccaa tcatgtttct
    27721 gctattgcag caattcctga agtgcgtgag aaactggttt ctctccaaca agaaattgcc
    27781 cagcaaggcg ggattgtcat ggatggtcgc gatattggaa ctgttgtatt gccacaagca
    27841 gaattgaaaa ttttcctagt agcttctgtt gatgagagag cagagcgtcg ttacaaggaa
    27901 aatattgcca agggaattga aacagacctt gaaaccctaa aaaaggaaat tgctgcgcgt
    27961 gactacaagg atagtcatcg tgagacttct cctctcaaac aagcagagga tgctgtctac
    28021 cttgatacaa ctggtttgaa cattcaagaa gtagttgaaa aaatcaaagc agaagctgaa
    28081 aaaagaatgt aaatgtagaa aagccgatag attgatatcg gtttttttct aaatttgtca
    28141 aaatgctgat tttagggtat aatagttgct gttcgagaaa ttttgatttt caaagaatag
    28201 tgaatgatga taaggagaaa ccatgaacaa tttaccaaat tgtccaaaat gtaactcaga
    28261 gtatgtctac gaagacggtg ccctactggt ttgcccagag tgtgctcatg agtggaatcc
    28321 tgctgaagtt gcagaagtag aagaaggtct tgtcgctatc gatgccaacg gaaataaatt
    28381 ggctgatggt gatatagtaa ctctcatcaa ggacttgaaa gtaaaaggtg cgccaaaaga
    28441 tttgaaacaa gggacgcgcg tgaaaaatat ccgcatcgta gaaggcgacc acaatatcga
    28501 ctgtaagatt gatggttttg gtgccatgaa acttaaatca gagtttgtga ggaagattta
    28561 agcatgtcaa aacactataa acttgtattt tatagccgta tcttcttgtt tctagcggct
    28621 tttacgggag tttatcttga aattactagg catggtggtt ttgggatgct tctctattac
    28681 acggttctgt ccaacctctt ggtaactatt tttacccttt atcttctaaa ggttatgagc
    28741 cgtgtaggtg aaaattggca aaggccaagt ctcttgcgct taaaaggtgg ggtcaccatg
    28801 agtatcatga ttacctgtgt gatttaccat ttcctcttgg cgcccattgc gactaatttc
    28861 tataccctag aaaatttcct ttgccactat atcgttccca tctggttttt agcggatacc
    28921 ctcttttttg acaaacaggg tcaatacaag atttgggatc cagcagtgtg gaccatttta
    28981 ccctttctgt atatgatgtt tgctcttttt aatggcttgg ttctaaaact caatattcca
    29041 aatgccaagg ataatccttt cccttacttc tttttgaatg tgaacaaggg ttggaatgtt
    29101 gtgtttaagt ggtgtctgat tatctttgtt gcctatatgg tagcaggatt tattttctac
    29161 tttatcaagc aaatcaagag aaagtcatcc taatactctt cgaaaatctc ttcaaaccac
    29221 gtcagtttcc atctgcaacc tcaaaacact gttttgaaca acctgcggct agcttcctag
    29281 tttgctcttt gattttcatt gagtataaga tacaagggat tcattttcga atttaagaag
    29341 gagtctacaa accaatgagg cttcttcttt tcttgcttat ttgataacta tcaaaaaagt
    29401 agaagattaa gagaaatata gaaagagatt tcatgaaaca atttttagaa cgggccagca
    29461 ttttggctct ctccctcgtt ttgattacct ccttttccat ttcgagtgcc ctaccagcca
    29521 tgtttgacta ttatcagggt tattctaagg aacaaattga gctcttggtg agcttgcctt
    29581 cctttggaat catgatgatg ttactgctaa atggtttctt agaaaaaata tttcctgagc
    29641 gcttacagat tagtttgggc ttgctgattt tatcattgag cggtacagct cccttctggt
    29701 accaagccta tccctttgtc tttggaacac ggcttctctt tggtttgggt cttgggatga
    29761 tcaatgccaa ggccatttct attatcagtg aacgctatca aggaaaaagg cgaattcaga
    29821 tgttagggct acgcgcttct gcagaggtcg ttggagcttc tctcattacc ttggccgtcg
    29881 gtcagttgtt ggcctttggt tggacagcta tctttctagc ctatagtgct ggatttttgg
    29941 tgctgcccct ttatctgctc tttgtccctt atggaaaatc aaagaaagaa gtcaagaaaa
    30001 gagcgaagaa agcaagtcgt ttaactcgag aaatgaaagg cttgattttt accttagcta
    30061 tcgaagcggc agttgtagtt tgtaccaata cagctattac catccgtatt ccaagtttga
    30121 tggtggaaag aggattgggg gatgcccagt tatctagttt tgttcttagt atcatgcagt
    30181 tgatcgggat tgtggctggg gtgagttttt ctttcttgat ttctatcttt aaagagaaac
    30241 tgctcctctg gtctggtatt acctttggct tggggcaaat cgtgattgcc ttgtcttcat
    30301 ccttgtgggt ggtagtagca ggaagtgttc tggctggatt tgcctatagt gtagtcttga
    30361 cgacggtctt tcaacttgtc tctgaacgaa ttccagctaa actcctcaat caagcaactt
    30421 catttgctgt attaggctgt agtttcggag cctttacgac cccatttgtt ctaggtgcaa
    30481 ttggcttact aactcacaat gggatgttgg tctttagtat cttaggaggt tggttgattg
    30541 taatctctat ctttgtcatg tacctacttc agaagagagc ttaggattga ttcctaagtt
    30601 tttcttttga tactcaatga aaatcaaaga gcgtagttga ttgagtttgg aatagtacgc
    30661 tgtagctgct aaaatatttc tagaaattaa tttgactttc ctaatagagt tgttcatatc
    30721 ttatttcaat ctactataga aagctagccg caggttgctc aaaatagtgt tttgaggttg
    30781 cagatggaaa ctgacgtagt ttgaagagat tttcgaagag tatgagattt ttatacccat
    30841 acaatatttg ttttaggtcc ttgtttacag actaatttct tgataaaata gaggttatga
    30901 cgagatataa agcaactatt tcctatgatg gttatgcctt tgctggcttt cagcgccagc
    30961 ctcatgcgcg tagcgttcag gaagaaattg aaaaaacctt gaccagatta aataaagggc
    31021 aaaccattac tgttcacggt gctggtagga cagatagtgg ggttcatgcc ctgggacagg
    31081 tcattcattt tgacctgcct tatcagatgg atgaggagaa actccgtttt gccttggata
    31141 cccagtctcc tgaagatatt gatgtgattt cgattgagct tgtggcagat gattttcatt
    31201 gccgttatgc caaacatagc aagacctatg agtttattgt ggatagagga cgtcccaaaa
    31261 atcctatgcg ccgtcactat gccacccact ttccctaccc actcgatgtg gaacgaatgc
    31321 agattgcaat caaaaagcta gagggaaccc atgattttac cggttttaca gcctctggga
    31381 ctagtgtaga ggataaggtt cgcaccatca cagaagctag tttaatagtc gatgagacag
    31441 gacaattttt gacctttacc ttttcaggaa atggtttctt gtataaacag attcgcaata
    31501 tggtggggac tcttctcaaa atcggtaaca accgcatgcc agtagagcag attgctctca
    31561 tcttggagaa gaaggacagg caacttgcag gtcccactgc agcaccaaat ggtttgtatt
    31621 taaaggagat tcgttatgaa gaataatcgt attttagcac tttctggaaa tgatattttt
    31681 agtggtggtg gactgtcagc tgatttggct acctatacct tgaacggctt gcatgggttt
    31741 gtagcagtga cttgtttgac agccttgaca gaaaaaggat ttgaagtctt tccaactgat
    31801 gataccattt ttcaacatga attagatagc ttgcgtgatg tggaatttgg gggaattaag
    31861 attggtcttc tccctactgt cagtgtggct gagaaggcct tggactttat caaacaacgc
    31921 ccaggagtac ctgtggtgtt ggatcctgtc ttggtctgca aggaaacgca tgatgtagct
    31981 gtcagtgagc tctgccaaga gttgattcgc ttcttccctt atgtcagtgt gattacgcct
    32041 aatctcccag aagcagaatt attatccggt caggaaatta aaaccttgga agacatgaaa
    32101 actgcagcgc agaaattgca tgatttagga gcgccagcag tcattatcaa gggaggcaat
    32161 cgtcttagtc aggacaaggc tgtggatgtc ttttatgatg gacagacctt tactatccta
    32221 gaaaatccag ttatccaagg ccaaaatgct ggtgcaggtt gtacctttgc ctctagcatt
    32281 gccagtcacc tggttaaagg tgataaactt ttgccagcag tagaaagctc taaggctttc
    32341 gtttatcgtg ctattgcaca agcagatcag tatggagtaa gacaatatga agcaaacaaa
    32401 aacaactaaa atcgcccttg tatccctatt aaccgccctt tctgtggttc taggttattt
    32461 cttaaaattc ccaacaccta caggaattct aactctttta gatgctggtg tcttctttgc
    32521 ggccttttac tttggtagtc gtgaaggagc ggtagtcgga ggactagcaa gtttcttgat
    32581 tgacctctta tcaggctacc ctcagtggat gttctttagc ttggtcaacc atggcttgca
    32641 gggatttttc gcaggattta aaggaaaaag tcagtggtta ggccttattt tagcaactat
    32701 tgccatggta ggaggctacg ccttgggttc tactttgatg aatggctggg cagcagccct
    32761 cccagaaatt ctaccgaatt ttatgcaaaa tatggtaggg atgattgtag gatttattct
    32821 tagtcaaagt atcaagaaga ttaagtaata ctcttcgaaa atctcttcaa accacgtcag
    32881 cttccatctg caacctcaaa acactgtttt gagcagcctg aggctagctt tctagtttgc
    32941 actttgattt tcattgagta taaagaggtt gagtaaaaag tctttcaaat aagaaaaacg
    33001 cattatatca agtcttgact gaactg
//
LOCUS       DAVLHC010000021        32910 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.021, whole genome shotgun sequence.
ACCESSION   DAVLHC010000021 DAVLHC010000000
VERSION     DAVLHC010000021.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 32910)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 32910)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..32910
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.021"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            290..859
                     /locus_tag="VXE25_001101"
     CDS             290..859
                     /locus_tag="VXE25_001101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000443767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0771576.1"
                     /translation="MESIFVKLAQYPSIETERLLLRPVTLDDAEAMFDYASDKGNTRY
                     TFPTNQSLEETKNNIAQFYLANPLGRWGIELKSNGKFIGTIDLHKIDPVLKKVAIGYI
                     INQTYWNQGLTTETNRAVIELAFEKIGMNKLVALYDKANPASGKVMEKSGMRFSHAEP
                     YACMYQHEKGRIVTRVHYVLTKEDYFANK"
     gene            927..1577
                     /locus_tag="VXE25_001102"
     CDS             927..1577
                     /locus_tag="VXE25_001102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000387331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComEA family DNA-binding protein"
                     /protein_id="HEV0771577.1"
                     /translation="MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQ
                     AEVAAVSKDLVSEKEVNKEEKEEPLEQDLITVDVKGAVKSPGIYDLPVGSRVNDAVHK
                     AGGLTEQADSKSLNLAQKVSDEALVYVPTKGEESVSQQTGLGTASSISKEKKVNLNKA
                     SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD"
     gene            1561..3243
                     /locus_tag="VXE25_001103"
     CDS             1561..3243
                     /locus_tag="VXE25_001103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000942381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComEC/Rec2 family competence protein"
                     /protein_id="HEV0771578.1"
                     /translation="MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCL
                     FIQFPWKSAGKVLIICGIFGFWFVFQNWQQSQVSQNLVDSVERVRILPDTIKVNGDSL
                     SFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
                     LKTQGIYQTLNIKKIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLL
                     GYLNTDFEEMNELYSSLGIIHLFALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPF
                     SLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIVMPNFFLTAGGVLSC
                     AYAFILTMTSKEGEGLKAVASESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDL
                     TFLPLLSILFVLSFLYPVIQLNFIFEWLEGIIRLVSQVARRPLVFGQPNAWLLILLLI
                     SLALVYDLRKNIKGLTVLSLLITGLFFLTKYPLENEITMLDVGQGESIFLRDVTGKTI
                     LIDVGGKAESYKKIEKWQEKMTTSNAQRSLIPYLKSRGVAKIDQLILTNTEV"
     gene            3348..4004
                     /locus_tag="VXE25_001104"
     CDS             3348..4004
                     /locus_tag="VXE25_001104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CpXC domain-containing protein"
                     /protein_id="HEV0771579.1"
                     /translation="MMKRKIRMTTIFLTRTSCSNCGKQSTFERFDRVYAAKTPEIISA
                     ILDWDFFKFTCHNCNHKVLIDYPTVVVDEEQKTIIQYCADGNVDVLSMQICSLISEGV
                     NLSEYRIRVVSDIESFVEKVQIVSVGYDDRAIELMKYMNSPLEDGDIQFNYEHMVFTK
                     VGHENYQFMFINNQIAVASLDFSQEQYEYYLADVEDLETNTYYIDSRWAESFFRTSLA
                     "
     gene            4133..5245
                     /locus_tag="VXE25_001105"
     CDS             4133..5245
                     /locus_tag="VXE25_001105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HEV0771580.1"
                     /translation="MVRRNSKITRQQKKIRDAFVSERTVEIIPAKREFTDVKTKKLRV
                     AAYCRVSTFDESQSGSFELQKQTYTERINSNPDWIMAGIYADQGASGTSIKRREQFQQ
                     MLHDCRCGKIDLIIVKSVSRFARNQLDFISIYRELKALSPPVGIYIEDINLNTLDTNS
                     EFILGIMAIVAQGESEQKSASITWSVIERFKRGIPMIPTHNLLGYTKDQYGRVVIDET
                     EAKIVRLIYDSYIEGMTASEIASTLMTNHIPTVTGLERWTSLAVYNILRNEKYKGEII
                     MQKTYTVDCFSHKTRKNNGEKPKYRLKNGIPSIIPESRWDLVQELLKQPRRKSKSTSE
                     IFVPKLYIKKLKSGKLRDFVVLDPSWKSEDIHEVFK"
     gene            5260..5676
                     /locus_tag="VXE25_001106"
     CDS             5260..5676
                     /locus_tag="VXE25_001106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001211122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771581.1"
                     /translation="MRFKDFNLEVVNVERYSSDYSMTVNKNFVTFSKGIVQALEYPAH
                     VLVAFNKDTKVMGIQVCRAKTRGAFSFSKPVGEQKGIVQVGHKTLKETLLTIMSEWKS
                     DKRYRVEGIHIPEDKAFVFELKDFDELSDFRKNDNR"
     gene            5786..5997
                     /locus_tag="VXE25_001107"
                     /pseudo
     CDS             5786..5997
                     /locus_tag="VXE25_001107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018368983.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1643 domain-containing protein"
     gene            6490..7707
                     /gene="mef(A)"
                     /locus_tag="VXE25_001108"
     CDS             6490..7707
                     /gene="mef(A)"
                     /locus_tag="VXE25_001108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012102963.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="macrolide efflux MFS transporter Mef(A)"
                     /protein_id="HEV0771582.1"
                     /translation="MEKYNNWKLKFYTIWAGQAVSLITSAILQMAIIFYLTEKTGSAM
                     VLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSVLTIVAFYMELPV
                     WMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAAL
                     LYSVWELNAIIAIDVLGAVIASITVAIVRIPKLGDRVQSLDPNFIREMQEGMAVLRQN
                     KGLFALLLVGTLYMFVYMPINALFPLISMDYFNGTPVHISITEISFASGMLIGGLLLG
                     LFGNYQKRILLITASIFMMGISLTISGLLPQSGFFIFVVCCAIMGLSVPFYSGVQTAL
                     FQEKIKPEYLGRVFSLTGSIMSLAMPIGLILSALFADRIGVNHWFLLSGTLIICIAIV
                     CPMINEIRKLDLK"
     gene            7827..9290
                     /gene="msr(D)"
                     /locus_tag="VXE25_001109"
     CDS             7827..9290
                     /gene="msr(D)"
                     /locus_tag="VXE25_001109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000420317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F type ribosomal protection protein Msr(D)"
                     /protein_id="HEV0771583.1"
                     /translation="MELILKAKDISVEFKGHDVLDINELEVYDYDRIGLVGANGAGKS
                     TLFKVLLGELIPPGCKMNHLGELAYIPQLDEVTLQEEKDFALVGKLGVEQLNIQTMSG
                     GEETRLKIAQALSAQVHGILADEPTSHLDREGIDFLIGQLKYFTGALLVISHDRYFLD
                     EIVDKIWELKDGKITEYWGNYSDYLRQKEEERKRQAAEYEQFIAERARLERAAEEKRK
                     QARKIEQKAKGSSKKKSTEGGGRLAHQKSIGSKEKKMHNAAKSLENRIAALGKVEAPE
                     GIRRIRFRQSKALELHNPYPIVGAEINKVFGDKALFENASFQIPLGAKVALTGGNGTG
                     KTTLIQMILNHEEGISISPKAKIGYFAQNGYKYNSNQNVMEFMQKDCDYNISEIRSVL
                     ASMGFKQNDIGKSLSVLSGGEIIKLLLAKMLMGRYNILIMDEPSNFLDIPSLEALEIL
                     MKEYTGTIVFITHDKRLLENVADVVYEIRDKKIKLKH"
     gene            complement(9408..9707)
                     /locus_tag="VXE25_001110"
     CDS             complement(9408..9707)
                     /locus_tag="VXE25_001110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018374804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771584.1"
                     /translation="MNQLEFQRNHLQMDYYSESYQDFERDFYRYSNMNIPLTFLTDDI
                     LKTMATSRKNYFVLNKEKSRDNRDHFFIFEVRTLEENPLIYHYTYKKTTTYLAEK"
     gene            complement(9694..10062)
                     /locus_tag="VXE25_001111"
     CDS             complement(9694..10062)
                     /locus_tag="VXE25_001111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254363.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771585.1"
                     /translation="MIDRSYLPFQSAREYQDTKMQKWMGFFLSEHTSALTDDANKVTY
                     MSDLSLEKKLLLLSQVYAGQLNTRIHVVKKNNQVSYTGTIPSLTKDFILIKTTTGHIN
                     LKLKDIVSIELVEEVLYESA"
     gene            complement(10059..10484)
                     /locus_tag="VXE25_001112"
                     /pseudo
     CDS             complement(10059..10484)
                     /locus_tag="VXE25_001112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003059255.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase"
     gene            10434..11273
                     /locus_tag="VXE25_001113"
     CDS             10434..11273
                     /locus_tag="VXE25_001113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014632453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771586.1"
                     /translation="MNRNDSSFFMCRAKTVSPDLKMGVDRERKIYQALYPLNIKAHTL
                     EFPTHGIDQIVWILEAIIPSLFVVAIIFMLTQLFAERYPNHLDTAQLYPFSKVAFALS
                     SLGVGVGYVSVLFIGICGFSFLVGSLISGFGQLDYPYPIYSLVNQEVTIGKIQDVLFP
                     GLFLAFLAFIVIVEVVYLIAYFFKQKMPVLFLSLIGIVGLLFGIQTIQPLQRIAHLIP
                     FTYLRSVEILSGSLPKQIDNVNLNWGMGLVLLPCLIILLLVGILFIESWGSSRKKEVF
                     NRS"
     misc_feature    11434..11565
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00558"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="ribosomal protein L20 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00558"
     gene            11581..12111
                     /gene="infC"
                     /locus_tag="VXE25_001114"
     CDS             11581..12111
                     /gene="infC"
                     /locus_tag="VXE25_001114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000848185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-3"
                     /protein_id="HEV0771587.1"
                     /translation="MKTIAKQDLFINDEIRVREVRLIGLEGEQLGIKPLSEAQALADN
                     ANVDLVLIQPQAKPPVAKIMDYGKFKFEYQKKQKEQRKKQSVVTVKEVRLSPTIDKGD
                     FDTKLRNARKFLEKGNKVKVSIRFKGRMITHKEIGAKVLAEFAEATQDIAIIEQRAKM
                     DGRQMFMQLAPATDKK"
     gene            12144..12344
                     /gene="rpmI"
                     /locus_tag="VXE25_001115"
     CDS             12144..12344
                     /gene="rpmI"
                     /locus_tag="VXE25_001115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001125942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L35"
                     /protein_id="HEV0771588.1"
                     /translation="MPKQKTHRASAKRFKRTGSGGLKRFRAYTSHRFHGKTKKQRRHL
                     RKASMVHSGDYKRIKAMLTRLK"
     gene            12396..12755
                     /gene="rplT"
                     /locus_tag="VXE25_001116"
     CDS             12396..12755
                     /gene="rplT"
                     /locus_tag="VXE25_001116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019786714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L20"
                     /protein_id="HEV0771589.1"
                     /translation="MARVKGGVVSRKRRKRILKLAKGYYGAKHILFRTAKEQVMNSYY
                     YAYRDRRQKKRDFRKLWITRINAAARMNGLSYSQLMHGLKLAEIEVNRKMLADLAVND
                     AVAFTALADAAKAKLGK"
     gene            12813..13193
                     /locus_tag="VXE25_001117"
     CDS             12813..13193
                     /locus_tag="VXE25_001117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HEV0771590.1"
                     /translation="MASKMLHTCLRVENLEKSIAFYQDAFGFKELRRRDFPDHAFTIV
                     YLGLEGDDYELELTYNYDHGPYVVGDGFAHIALSTPDLEALHQEHSAKGYEVTEPNGL
                     PGTTPNYYFVKDPDGYKVEVIREK"
     gene            13443..14243
                     /locus_tag="VXE25_001118"
     CDS             13443..14243
                     /locus_tag="VXE25_001118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate dehydrogenase electron transfer
                     subunit"
                     /protein_id="HEV0771591.1"
                     /translation="MNPTCKKRLGVIRLETMKVVAQEEIAPAIFELVLEGEMVEAMRA
                     GQFLHLRVPDDAHLLRRPISISSIDKANKQCHLIYRIEGAGTAIFSTLSQGDTLDVMG
                     PQGNGFDLSDLDEQNQVLLVGGGIGVPPLLEVAKELHERGVKVVTVLGFANKDAVILK
                     TELAQYGQVFVTTDDGSYGIKGNVSVVINDLDSQFDAVYSCGAPGMMKYINQTFDDHP
                     RAYLSLESRMACGMGACYACVLKVPESETVSQRVCEDGPVFRTGTVVL"
     gene            14206..15192
                     /locus_tag="VXE25_001119"
     CDS             14206..15192
                     /locus_tag="VXE25_001119"
                     /EC_number="1.3.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013193458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate dehydrogenase"
                     /protein_id="HEV0771592.1"
                     /translation="MVLFSAQEQLYYKEKIMTTNRLQVSLPGLDLKNPIIPASGCFGF
                     GQEYAKYYDLNLLGSIMIKATTLEPRFGNPTPRVAETPAGMLNAIGLQNPGLEVVLAE
                     KLPWLEREYPNLPIIANVAGFSKQEYAAVSHGISKATNVKAIELNISCPNVDHCNHGL
                     LIGQDPDLAYDVVKAAVEASEVPVYVKLTPSVTDIVTVAKAAEDAGASGLTMINTLVG
                     MRFDLKTRKPILANGTGGMSGPAVFPVALKLIRQVAQTTDLPIIGMGGVDSAEAALEM
                     YLAGASAIGVGTANFTNPYACPDIIENLPKVMDKYGISSLEELRQEVKESLR"
     gene            15234..17399
                     /gene="lytB"
                     /locus_tag="VXE25_001120"
     CDS             15234..17399
                     /gene="lytB"
                     /locus_tag="VXE25_001120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010976495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endo-beta-N-acetylglucosaminidase"
                     /protein_id="HEV0771593.1"
                     /translation="MNLGEFWYNKINKNRGRRLMKKVRFIFLALLFFLASPEGAMASD
                     GTWQGKQYLKEDGSQAANEWVFDTHYQSWFYIKADANYAENEWLKQGDDYFYLKSGGY
                     MAKSEWVEDKGAFYYLDQDGKMKRNAWVGTSYVGATGAKVIEDWVYDSQYDAWFYIKA
                     DGQHAEKEWLQIKGKDYYFKSGGYLLTSQWINQAYVNASGAKVQQGWLFDKQYQSWFY
                     IKENGNYADKEWIFENGHYYYLKSGGYMAANEWIWDKESWFYLKFDGKIAEKEWVYDS
                     HSQAWYYFKSGGYMAANEWIWDKESWFYLKFDGKMAEKEWVYDSHSQAWYYFKSGGYM
                     TANEWIWDKESWFYLKSDGKIAEKEWVYDSHSQAWYYFKSGGYMTANEWIWDKESWFY
                     LKSDGKMAEKEWVYDSHSQAWYYFKSGGYMAKNETVDGYQLGSDGKWLGGKATNENAA
                     YYQVVPVTANVYDSDGEKLSYISQGSVVWLDKDRKSDDKRLAITISGLSGYMKTEDLQ
                     ALDASKDFIPYYESDGHRFYHYVAQNASIPVASHLSDMEVGKKYYSADGLHFDGFKLE
                     NPFLFKDLTEATNYSAEELDKVFSLLNINNSLLENKGATFKEAEEHYHINALYLLAHS
                     ALESNWGRSKIAKDKNNFFGITAYDTTPYLSAKTFDDVDKGILGATKWIKENYIDRGR
                     TFLGNKASGMNVEYASDPYWGEKIASVMMKINEKLGGKD"
     gene            complement(17460..19115)
                     /gene="pavA"
                     /locus_tag="VXE25_001121"
     CDS             complement(17460..19115)
                     /gene="pavA"
                     /locus_tag="VXE25_001121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_094859469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rqc2 family fibronectin-binding protein PavA"
                     /protein_id="HEV0771594.1"
                     /translation="MSFDGFFLHHIVEELRSELVNGRIQKINQPFEQELVLQIRSNRQ
                     SHRLLLSAHPVFGRIQLTQTTFENPAQPSTFIMVLRKYLQGALIESIEQVENDRIVEI
                     TVSNKNEIGDHIQATLIIEIMGKHSNILLVDKSSHKILEVIKHVGFSQNSYRTLLPGS
                     TYIAPPSTESLNPFTIKDEKLFEILQTQELTAKNLQSLFQGLGRDTANELERILVSEK
                     LSAFRNFFNQETKPCLTETSFSPVPFANQVGEPFANLSDLLDTYYKDKAERDRVKQQA
                     SELIRRVENELQKNRHKLKKQEKELLATDNAEEFRQKGELLTTFLHQVPNDQDQVILD
                     NYYTNQPIMIALDKALTPNQNAQRYFKRYQKLKEAVKYLTDLIEETKATILYLESVET
                     VLNQAGLEEIAEIREELIQTGFIRRRQREKIQKRKKLEQYLASDGKTIIYVGRNNLQN
                     EELTFKMARKEELWFHAKDIPGSHVVISGNLDPSDAVKTDAAELAAYFSQGRLSNLVQ
                     VDMIEVKKLNKPTGGKPGFVTYTGQKTLRVTPDSKKIASMKKS"
     gene            19220..19717
                     /gene="ybeY"
                     /locus_tag="VXE25_001122"
     CDS             19220..19717
                     /gene="ybeY"
                     /locus_tag="VXE25_001122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018380869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA maturation RNase YbeY"
                     /protein_id="HEV0771595.1"
                     /translation="MYIEMVDETGQVSKEMLQQTQEILEFAAQKLGKEDKEMAVTFVT
                     NERSHELNLEYRNTDRPTDVISLEYKPELEIAFDEEDLLENSELAEMMSEFDAYIGEL
                     FISSDKAHEQAEEYGHSFEREMGFLAVHGFLHINGYDHYTPEEEAEMFGLQEEILTAY
                     GLTRQ"
     gene            19698..20093
                     /locus_tag="VXE25_001123"
     CDS             19698..20093
                     /locus_tag="VXE25_001123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000378166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol kinase"
                     /protein_id="HEV0771596.1"
                     /translation="MDSQDNKRKWKNRDLISSLEFAITGIFTAIKEERNMRKHAVTAL
                     VVILAGFVFQVSRIEWLFLLLSIFLVVAFEIINSAIENMVDLASHYHFSMLAKNAKDM
                     AAGAVLVVSLFAALTGALIFLPRIWDLLF"
     gene            20110..21009
                     /gene="era"
                     /locus_tag="VXE25_001124"
     CDS             20110..21009
                     /gene="era"
                     /locus_tag="VXE25_001124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002935752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase Era"
                     /protein_id="HEV0771597.1"
                     /translation="MTFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKI
                     MGIYTTDKEQIVFIDTPGIHKPKTALGDFMVESAYSTLREVDTVLFMVPADEARGKGD
                     DMIIERLKAAKVPVILVVNKIDKVHPDQLLSQIDDFRNQMDFKEIVPISALQGNNVSR
                     LVDILSENLDEGFQYFPSDQITDHPERFLVSEMVREKVLHLTREEIPHSVAVVVDSMK
                     RDEETDKVHIRATIMVERDSQKGIIIGKGGAMLKKIGSMARRDIELMLGDKVFLETWV
                     KVKKNWRDKKLDLADFGYNEREY"
     gene            21058..21882
                     /gene="mutM"
                     /locus_tag="VXE25_001125"
     CDS             21058..21882
                     /gene="mutM"
                     /locus_tag="VXE25_001125"
                     /EC_number="3.2.2.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001114577.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-formamidopyrimidine glycosylase"
                     /protein_id="HEV0771598.1"
                     /translation="MPELPEVETVCRGLEKLIIGKKISSIEIRYPKMIKTDLEEFQRE
                     LPSQIIESMGRRGKYLLFYLTDKVLISHLRMEGKYFYYPDQGPERKHAHVFFHFEDGG
                     TLVYEDVRKFGTMELLVPDLLDAYFISKKLGPEPSEQDFDLQVFQSALAKSKKPIKSH
                     LLDQTLVAGLGNIYVDEVLWRAQVHPARSSQTLTAEEATAIHDQTIAVLNQAVEKGGS
                     TIRTYTNAFGEDGSMQDFHQVYDKTGQECVRCGTIIEKIQLGGRGTHFCPNCQRRD"
     gene            21882..22487
                     /locus_tag="VXE25_001126"
     CDS             21882..22487
                     /locus_tag="VXE25_001126"
                     /EC_number="2.7.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004259526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dephospho-CoA kinase"
                     /protein_id="HEV0771599.1"
                     /translation="MRKIIGITGGIASGKSTVTNFLRQQGFQAVDADAVVHQLQKPGG
                     RLFEALVQHFGQEIILENGELNRPLLASLIFSNPEEQKWSKQIQGEIIREELATLREQ
                     LAQTEEIFFMDIPLLFEQDYSDWFAETWLVYVDRDTQVERLMKRDQLSKDEAESRLAA
                     QWPLEKKKDLASQVLDNNGNQNQLLNQVHILLEGGRQDDRD"
     gene            22474..23673
                     /locus_tag="VXE25_001127"
     CDS             22474..23673
                     /locus_tag="VXE25_001127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux MFS transporter"
                     /protein_id="HEV0771600.1"
                     /translation="MTEINWKDNLRIAWFGNFLTGASISLVVPFMPIFVENLGVGSEQ
                     VAFYAGLAISVSAISAALFSPIWGILADKYGRKPMMIRAGLAMTITMGGLAFVPNIYW
                     LIFLRLLNGVFAGFVPNATALIASQVPKEKSGSALGTLSTGVVAGTLTGPFIGGFIAE
                     LFGIRTVFLLVGSFLFLAAILTICFIKEDFQPVAKEKAIPTKELFTSVKYPYLLLNLF
                     LTSFVIQFSAQSIGPILALYVRDLGQTENLLFVSGLIVSSMGFSSMMSAGVMGKLGDK
                     VGNHRLLVVAQFYSVIIYLLCANASSPLQLGLYRFLFGLGTGALIPGVNALLSKMTPK
                     AGISRVFAFNQVFFYLGGVVGPMAGSAVAGQFGYHAVFYATSLCVAFSCLFNLIQFRT
                     LLKVKEI"
     gene            23673..23822
                     /gene="rpmG"
                     /locus_tag="VXE25_001128"
     CDS             23673..23822
                     /gene="rpmG"
                     /locus_tag="VXE25_001128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L33"
                     /protein_id="HEV0771601.1"
                     /translation="MRVKINLKCSSCDSINYLTSKNSKTHPDKIEVLKYCPKERKVTL
                     HLESK"
     gene            23862..24095
                     /gene="secG"
                     /locus_tag="VXE25_001129"
     CDS             23862..24095
                     /gene="secG"
                     /locus_tag="VXE25_001129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecG"
                     /protein_id="HEV0771602.1"
                     /translation="MYNLLLTILLVLSVVIVIAIFMQPTKNQSSNVFDASSGDLFERS
                     KARGFEAVMQRLTGILVFFWLAIALALTVLSSR"
     gene            24197..26551
                     /gene="rnr"
                     /locus_tag="VXE25_001130"
     CDS             24197..26551
                     /gene="rnr"
                     /locus_tag="VXE25_001130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000653285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease R"
                     /protein_id="HEV0771603.1"
                     /translation="MKDRIKEYLQDKGKMTVNDLAQALGKDSSKDFRELIKTLSLMER
                     KHQIRFEEDGSLTLEIKKKHEITLKGIFHAHKNGFGFVSLEGEEDDLFVGKNDVNYAI
                     DGDTVEVVIKKVADRNKGTAAEAKIIDILEHSLTTVVGQIVLDQEKPKYAGYIRSKNQ
                     KISQPIYVKKPALKLEGTEVLKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVL
                     ESMDIVSEFPEAVVKEAESVPDAPSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIK
                     ALKNGNLELGVHIADVSYYVTEGSALDKEALNRATSVYVTDRVVPMLPERLSNGICSL
                     NPQVDRLTQSAIMEIDKHGRVVNYTITQTVIKTSFRMTYSDVNDILAGDEEKRKEYHK
                     IVLSIELMAKLHETLENMRVKRGALNFDTNEAKILVDKQGKPVDIVLRQRGIAERMIE
                     SFMLMANETVAEHFSKLDLPFIYRIHEEPKAEKVQKFIDYASSFGLRIYGTASEISQE
                     ALQDIMRAVEGEPYADVLSMMLLRSMQQARYSEHNHGHYGLAADYYTHFTSPIRRYPD
                     LLVHRMIRDYGCSKEIAEHFEQVIPEIATQSSNRERRAIEAEREVEAMKKAEYMEEYV
                     GEEYDAVVSSIVKFGLFVELPNTVEGLIHITNLPEFYHFNERDLTLRGEKSGITFRVG
                     QQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQSSRSGRGRGSNRRSDKKEDKRKL
                     GRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKGRRTK"
     gene            26514..26981
                     /gene="smpB"
                     /locus_tag="VXE25_001131"
     CDS             26514..26981
                     /gene="smpB"
                     /locus_tag="VXE25_001131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002894882.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SsrA-binding protein SmpB"
                     /protein_id="HEV0771604.1"
                     /translation="MAKGEGKVVAQNKKARHDYTIVDTLEAGMVLTGTEIKSVRAARI
                     NLKDGFAQVKNGEVWLSNVHIAPYEEGNIWNQEPERRRKLLLHKKQIQKLEQETKGTG
                     MTLVPLKVYIKDGYAKLLLGLAKGKHDYDKRESIKRREQNRDIARVMKAVNQR"
     gene            26997..27857
                     /gene="tehB"
                     /locus_tag="VXE25_001132"
     CDS             26997..27857
                     /gene="tehB"
                     /locus_tag="VXE25_001132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000413836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent methyltransferase TehB"
                     /protein_id="HEV0771605.1"
                     /translation="MEKSVAYKRMPLWNKQTMPEAVQQKHNTKVGTWGKITVLKGALK
                     FIELTEEGEVLAEHLFEAGADNPMAQPQAWHRVEAATDDVEWYLEFYCKPEDYFAKKY
                     NTNPVHSEVLEAMQTVKQGKALDLGCGQGRNSLFLAQQDFDVTAVDQNGLALEILQSI
                     VEQEDLDMPVGLYDINSASIEQEYDFIVSTVVLMFLQADRIPAIIQNMQEKTSVGGYN
                     LIVCAMDTEDYPCSVNFPFTFKEGELADYYKDWELVKYNENPGHLHRRDENGNRIQLR
                     FATLLAKKIK"
     gene            27930..28883
                     /gene="coiA"
                     /locus_tag="VXE25_001133"
     CDS             27930..28883
                     /gene="coiA"
                     /locus_tag="VXE25_001133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000495911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein CoiA"
                     /protein_id="HEV0771606.1"
                     /translation="MFVARDARGELVNVLEDKLEKQAYTCPACGGQIHLRQGPSVRTH
                     FAHKSLKDCDFFFENESPEHIANKESLYHWLKKETKVQLEYPLSELKQIADVFVNGNL
                     ALEVQCSPLPQKVLKERSEGYRSQGYQVLWLLGQKLWLKERLTRLQQGFLYFSQNMGF
                     YVWELDKEKQVLRLKYLIYQDLRGKLHYQIKEFSYGQGSLLEILRLPYKRQKISHFTV
                     SEDKDICRYIRQQLYYQNLFWMKEQAEAYQKGENILTYGLKEWYPQIRPIVGKFFQIE
                     QDLTSYYQHFYTYYQKNPQNDWQKLYPPAFYQQYFLKNMVE"
     gene            28902..30704
                     /gene="pepF"
                     /locus_tag="VXE25_001134"
     CDS             28902..30704
                     /gene="pepF"
                     /locus_tag="VXE25_001134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004252660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oligoendopeptidase F"
                     /protein_id="HEV0771607.1"
                     /translation="MVLQRNEINEKDTWDLSTIYPTDQAWEEALKDLTEQLETVAQYE
                     GHLLDSADNLLEITEFSLEMERQIEKLYVYAHMKNDQDTREAKYQEYYAKAMTLYSQL
                     DQAFSFYEPEFMEISEKQYADFLEAQPKLQVYQHYFDKLLQGKDHVLSQREEELLAGA
                     GEIFGSASETFAILDNADIVFPYVLDDDGKEVQLSHGTYTRLMESKKREVRRGAYQAL
                     YATYEQFQHTYAKTLQTNVKVQNYRAKVRNYKSARHAALAANFVPESVYDNLVAAVRK
                     HLPLLHRYLELRSKILGISDLKMYDVYTPLSSVEYSFTYQEALKKAEDALAVLGEDYL
                     SRVKRAFSERWIDVYENRGKRSGAYSGGSYDTNAFMLLNWQDNLDNLFTLVHETGHSM
                     HSSYTRETQPYVYGDYSIFLAEIASTTNENILTEKLLEEVEDDATRFAILNNFLDGFR
                     GTIFRQTQFAEFEHAIHQADQNGEVLTSDFLNKLYADLNQEYYGLSKEDNPEIQYEWA
                     RIPHFYYNYYVYQYSTGFAAASALAEKIVHGSQEDRDRYIDYLKAGKSDYPLNVMRKA
                     GVDMEKEDYLNDAFAVFERRLNEFEALVEKLGLA"
     gene            30706..31419
                     /locus_tag="VXE25_001135"
     CDS             30706..31419
                     /locus_tag="VXE25_001135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812425.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-methyltransferase"
                     /protein_id="HEV0771608.1"
                     /translation="MVESYSKNANHNMRRPVVKEEIVDLMRQRQKQVTGFLKELEDFA
                     RKENIPIIPHETVAYFRFIMETMQPKNILEIGTAIGFSALLMAEHAPNAKITTIDRNP
                     EMIGFAKENFAQFDSRKQITLLEGDAVDVLSTLTESYDFVFMDSAKSKYIVFLPEILK
                     HLEVGGVVVLDDIFQGGDVAKDIMEVRRGQRTIYRGLQKLFDATLDNPELTATLVPLG
                     DGILMLRKNVADVQLSESE"
     gene            31486..32427
                     /gene="prsA"
                     /locus_tag="VXE25_001136"
     CDS             31486..32427
                     /gene="prsA"
                     /locus_tag="VXE25_001136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399245.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase PrsA"
                     /protein_id="HEV0771609.1"
                     /translation="MKKKLLAGAITLLSVATLAACSKGSEGADLISMKGDVITEHQFY
                     EQVKNNPSAQQVLLNMTIQKVFEKQYGSELDDKEVDDTIAEEKKQYGENYQRVLSQAG
                     MTLETRKAQIRTSKLVELAVKKVAEAELTDEAYKKAFDEYTPDVTAQIIRLNNEDKAK
                     EVLEKAKAEGADFAQLAKDNSTDEKTKENGGEITFDSASTEVPEQVKKAAFALDVDGV
                     SDVITATGTQAYSSQYYIVKLTKKTEKSSNIDDYKEKLKTVILTQKQNDSTFVQSIIG
                     KELQAANIKVKDQAFQNIFTQYIGGGDSSSSSSTSNE"
     gene            complement(32546..32887)
                     /locus_tag="VXE25_001137"
                     /pseudo
     CDS             complement(32546..32887)
                     /locus_tag="VXE25_001137"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
BASE COUNT        10108 a         5846 c         7204 g         9752 t
ORIGIN      
        1 tcatatggga ctttttttct acacaaaaat aagctccata atatctatag gggatttacc
       61 cactacaaat attatagagc ctttttaatt tcttttggga ttccgattaa cattgagata
      121 acctaccttt caattgacgg tcttgttttg gttgtcacat tccagttcat aaatcaaaaa
      181 tgtgacggtt tcattgtata tgaaaccgct tcaaaaatca agaaaaactt gtcatcccaa
      241 tttttttatg ctagactagt gaaaatcaag ttctaatgga gggaaaagta tggaatcaat
      301 ttttgtaaaa cttgcccagt atccgtctat agaaacggag cgtttattgc ttagacctgt
      361 aactttggat gatgcggaag caatgtttga ctatgcctcg gacaagggta atacacgtta
      421 cacttttcca accaatcaaa gcttggaaga aaccaagaat aacattgctc agttctactt
      481 ggctaatccc ttgggacgtt ggggaataga actaaaaagc aatggcaaat ttatcggaac
      541 aattgatttg cacaagattg atcctgttct taagaaggta gctattggtt atattatcaa
      601 ccaaacgtat tggaatcaag gattaacgac agaaaccaat cgtgctgtga ttgagctagc
      661 ttttgagaag ataggaatga ataagttagt tgctttatac gataaggcta atcccgcatc
      721 aggaaaggtc atggagaaat caggaatgcg tttttcccat gcagaaccat atgcttgtat
      781 gtaccagcat gaaaaaggcc gaatcgtgac aagagttcat tatgtcttga ccaaggaaga
      841 ctattttgca aataaataag cagttgaaaa gaaatttttc gactgttttt tcttcctctt
      901 acgaataatc taagagagga gaaaatatgg aagcaattat cgagaaaatc aaagagtata
      961 aaatcatcgt catctgtact ggtctgggct tgcttgtagg aggatttttc ctgctaaaac
     1021 cagctccaca aacacctgtc aaagagacga atttgcaggc tgaagtcgca gctgtttcca
     1081 aggatttggt atccgaaaag gaagtgaaca aggaagaaaa ggaagaaccc cttgaacaag
     1141 atctaatcac agtagatgtc aaaggtgctg tcaaatcgcc agggatttat gacttgcctg
     1201 taggtagtcg agtcaatgat gctgttcata aggctggtgg cttgacagag caagcagaca
     1261 gcaagtcgct caatctagct cagaaagtta gtgatgaggc tctggtttac gttcctacta
     1321 agggagaaga atcagttagc caacagactg gtttggggac agcttcttca ataagcaagg
     1381 aaaagaaggt caatctcaac aaggccagtc tggaagaact caagcaggtc aagggactgg
     1441 gaggaaaacg agctcaggac attatcgacc atcgtgaggc aaatggcaag ttcaagtcag
     1501 tagacgagct caagaaggtc tctggcattg gtggcaaaac aatagaaaag cttaaagact
     1561 atgttacagt ggattaagaa tttctctatt cccctaattt acctgagttt tctattactt
     1621 tggctttatt acgctatttt ctcagcatct tatcttgctt tgttgggctt tgtttttctg
     1681 ctagtctgtc tctttatcca atttccgtgg aaatctgctg gtaaagttct aataatttgc
     1741 ggaatctttg gattttggtt tgtttttcaa aattggcaac agagtcaagt gagtcaaaat
     1801 ttggtggatt ctgttgaaag ggtacggatt ttaccagaca ctattaaggt taacggtgat
     1861 agtctatcct ttcgtggcaa gtctaacggt cgtgctttcc aagtctatta taaactccag
     1921 tccgaggagg agaaagaagc ctttcaagct ttaaccgacc tgcatgagat aggactagaa
     1981 gggaagcttt cggagccaga agggcagaga aattttggtg gctttaatta ccaagcctat
     2041 ctgaagactc agggaattta ccagactctc aatatcaaaa aaatccagtc acttcaaaag
     2101 attggcagtt gggatatagg agaaaacttg tccagtttac gtcgaaaggc tgtggtttgg
     2161 attaagacgc actttccaga ccctatgcgc aattacatga caggactctt gctgggatat
     2221 ctgaacaccg actttgagga gatgaatgag ctttattcca gtctaggaat tatccacctc
     2281 tttgccctat ctggcatgca ggtaggtttt ttcatgaatg gatttaagaa acttctcttg
     2341 cgattgggct tgacccaaga aaagttgaaa tggctgactt atcccttttc ccttatctat
     2401 gcgggactaa ctggattttc agcatcggtt attcgcagtc tcttgcaaaa gctactggct
     2461 caacatgggg ttaagggctt ggataatttt gccttgacgg tgcttgtcct ctttattgtc
     2521 atgccaaact ttttcttgac agcaggagga gtcttgtcct gcgcttatgc ttttatcctg
     2581 accatgacca gcaaagaagg ggaggggctc aaggctgttg ctagtgaaag tctagtcatc
     2641 tccttgggca tattgcccat tctatccttc tattttgcgg aatttcaacc ttggtctatc
     2701 cttttgacct ttgtcttttc ctttctattt gacttgacct tcttaccgct cttgtctatt
     2761 ttatttgtcc tttcctttct ctatccagtc attcagctga actttatctt tgaatggtta
     2821 gagggcatta ttcgcttggt ctcgcaggtg gcaaggagac cgcttgtctt tggtcaaccc
     2881 aacgcatggc ttttaatctt attgttaatt tccttggctt tggtctatga tttgaggaaa
     2941 aacattaaag gattaacagt attgagttta ttgattacag gtctcttttt ccttaccaag
     3001 tatccactgg aaaatgaaat caccatgctg gatgtggggc aaggagaaag tattttccta
     3061 cgggatgtaa ctgggaaaac cattctcata gatgtaggtg gtaaggcaga atcttataag
     3121 aaaatcgaaa aatggcaaga aaagatgacg accagcaatg cacagagaag cttgataccc
     3181 tatcttaaaa gtcgaggagt agctaagatt gaccagctga ttttgacaaa tacggaagtg
     3241 tgagttctaa aattgataca atacaattta actttttttt gaaaaaaatt ccaaaattta
     3301 ttttgcattg cgaatataat aagtgagagc aagttgctta cttaataatg atgaagagga
     3361 aaattagaat gacaacaatt tttttaacaa gaacaagctg cagcaattgt ggaaaacaaa
     3421 gtacatttga aagatttgat agggtttatg cggcgaagac tcctgagatt atttctgcta
     3481 ttttagactg ggatttcttt aagtttactt gccataactg taaccacaag gtgctaattg
     3541 attacccaac agtcgtagta gatgaagaac aaaaaacaat tattcagtat tgtgcagatg
     3601 gtaatgttga tgtactttca atgcaaatat gctctttgat ttcagagggt gtcaatctca
     3661 gtgagtatag aattcgagta gtttcggata tagagtcttt cgttgagaag gtacagattg
     3721 tttcagtagg gtatgatgat agagcaattg agcttatgaa gtatatgaat agtcctcttg
     3781 aggatggtga tattcagttt aactatgaac atatggtttt caccaaggtt ggacatgaaa
     3841 actatcaatt tatgtttatt aataaccaga ttgcagtagc atctctcgac ttttctcaag
     3901 aacaatatga gtactacctt gctgatgttg aagacctaga aactaacaca tattacatag
     3961 actctagatg ggcggaatca ttctttcgta ccagtttggc ataaaattca aaatctattt
     4021 ataagtataa atggcctgat ttttggttag gtcatttttt atcttctaat ttagaaaaac
     4081 gtagttaata tatataatta ttatgtagat ttctagaaag gaggtaaaac caatggtaag
     4141 acggaattct aaaattaccc gtcaacagaa gaaaattcga gatgcatttg tatctgagag
     4201 aactgttgaa attattcctg caaagcgaga gttcactgat gttaaaacta agaagttacg
     4261 tgttgctgca tattgtcgag taagtacttt tgacgaatct cagtcaggta gttttgaact
     4321 tcaaaaacaa acctatactg aaagaatcaa tagtaatcct gattggataa tggctggaat
     4381 ctatgctgac caaggtgcat caggaacatc aatcaaacga cgtgaacaat tccaacagat
     4441 gcttcatgat tgtagatgtg ggaagattga cttgataatc gttaagagtg ttagcaggtt
     4501 tgctcgtaat cagctagatt tcattagtat ttaccgagag ttgaaggcac tatcccctcc
     4561 agttggaata tatatcgaag atataaattt gaatacactt gatacgaata gtgaattcat
     4621 tcttggtatt atggccatag tagctcaagg tgagagtgaa caaaaaagtg cgtcaattac
     4681 atggtctgtc attgaacgct ttaaaagagg gataccaatg attcctaccc ataaccttct
     4741 tgggtatacg aaagaccagt atggtcgagt agtgatagat gagacagaag caaaaattgt
     4801 tcgcctaata tatgattcgt acatcgaagg tatgactgca agtgagattg cctctacttt
     4861 aatgaccaat catataccaa cagttactgg tttggagcgt tggacaagtt tagctgttta
     4921 taatattctc agaaacgaga aatataaagg cgaaatcatc atgcagaaga catatactgt
     4981 tgattgtttt agtcataaaa cacggaaaaa taatggtgaa aagccaaaat atcgattaaa
     5041 aaatggaatt ccctctatca taccagaatc aagatgggat ttagtacaag aattactcaa
     5101 gcaacctaga agaaaatcga aatctacttc tgagatattt gtacctaaac tctacatcaa
     5161 gaaactcaaa tctggtaagt tgagggattt tgttgtactt gatcctagtt ggaaatcgga
     5221 agacattcac gaagttttta aataagaaag aggtaaatta tgcgttttaa agattttaat
     5281 cttgaagttg ttaatgttga acgttactca tcagattata gcatgacggt gaacaagaac
     5341 tttgttacat ttagtaaagg aattgtccaa gctttagaat acccagcaca tgtactggtt
     5401 gcctttaata aggatacaaa ggtaatgggt atacaagttt gtcgtgcaaa aactagggga
     5461 gcattttctt tttcaaaacc tgttggggag caaaaaggta ttgttcaggt aggtcataaa
     5521 actttaaaag aaacactctt aacaatcatg agtgaatgga aatctgataa gcgttataga
     5581 gtagagggga ttcacattcc tgaagataaa gcttttgttt ttgaattgaa ggactttgat
     5641 gaactatctg attttcgtaa aaacgacaat agatagtaag gaacgaagat aaaaattatt
     5701 ggtaggagta caactattgt attcctgcca ttttcatatc cttgcaaggg ggttcatgtt
     5761 aaaatatact gtaggaggta actctatgaa cgataaagtt acaaaagtca gactagccta
     5821 tcctttggga gaagacctaa tctatgtatt cctgaaaaat ataatgccta ccgtagattc
     5881 ctactgggat gcttaggaac gaatccactc gtggctatat gtatgaatcc ctcagcagct
     5941 aatgaggact atagcgatcg tacaatcaac cgaattctaa atgctagtaa aaaaattata
     6001 tgaagataag ctcaccgttg aattcaagtc agggattgag attgacgaag agatatagaa
     6061 tattaaccgc aatttaaggg ctaaccccct ttggcggttt ttaatggatt tttttaattt
     6121 ataagttgct taaaatgact tattgtgtta aaatatatga taatccaaat aagaatttag
     6181 gaggaaccga aactatgaca gcctcaatgc gtttaagata agctggcaat aagaaaagca
     6241 gaatctatac ccgatgatag gcttttttgt tgtgcttatt tatacgatat tgagcattca
     6301 ttagttacgg tgaggatatt ggttatttaa ctataccttt atttaactat gtctttaata
     6361 tgaatgtttc caaattgtat gtatgcagac caaaagccac attgtggatt taggcctgca
     6421 tttttttatt gcctataatg ctattcaaaa tagaaattta agcaaaataa tatgcaggag
     6481 ataatataaa tggaaaaata caacaattgg aaacttaagt tttatacaat atgggcaggg
     6541 caagcagtat cattaatcac tagtgccatc ttgcaaatgg cgattatttt ttaccttaca
     6601 gaaaaaactg gatccgcgat ggtcttgtct atggcttcac tattaggttt tttaccctat
     6661 gcggtctttg gacctgcaat tggtgtgcta gtggatcgtc atgataggaa gaagataatg
     6721 attggtgctg atttaattat cgcagcagct ggttcggtgc ttactattgt tgcattctat
     6781 atggagctac ctgtctggat ggttatgata gtattgttta tccgtagcat tggaacagct
     6841 tttcacaccc cggctctcaa tgcggttacg ccacttttag taccagaaga acagcttacg
     6901 aaatgtgcag gctatagtca gtctttgcag tctataagct atattgttag tccggcggtt
     6961 gcagcactct tatactccgt ttgggaacta aatgctatta ttgccatcga tgtattgggt
     7021 gctgtgattg catctattac ggtagcaatt gtacgtattc ctaagctggg tgatcgcgtg
     7081 caaagtttgg acccaaattt cataagagaa atgcaagaag gaatggctgt actacggcaa
     7141 aataaaggat tatttgcttt attactcgtt ggaacattat atatgtttgt ttatatgcca
     7201 attaatgcac tattcccttt aattagcatg gattacttta atggaacacc tgtgcatatt
     7261 tctattacgg aaatttcctt tgcatctgga atgttgatag ggggtctatt attagggtta
     7321 tttgggaatt accaaaagcg aatcttatta ataacggcat ccatttttat gatggggata
     7381 agcttaacca tttcaggatt acttccccaa agtggatttt tcatttttgt agtctgctgt
     7441 gcaataatgg ggctttctgt tccgttttac agcggtgtgc aaacagctct ttttcaggag
     7501 aaaattaagc ctgaatattt aggacgtgta ttttctttaa ctggaagtat catgtctctt
     7561 gctatgccaa ttggattaat tctttctgca ctctttgctg atagaatcgg tgtaaatcat
     7621 tggtttttac tatcaggtac tttaattatt tgcattgcaa tagtttgccc aatgataaat
     7681 gagattagaa aattagattt aaaataaaca atattggagg gatatttatg tatcttattt
     7741 tcatgtaatt cttcctgcta aaatcgcagg gtttttcctg cgtacaagca aatgaaagca
     7801 tgcgattata gacaggagga aatgttatgg aattaatatt aaaagcaaaa gacattagtg
     7861 tggaattcaa aggacacgat gttttagata taaatgaatt agaagtatat gattatgacc
     7921 gtattggttt agtaggagca aatggtgcag gaaaaagcac tttattcaag gtacttttag
     7981 gagaattaat tcccccagga tgtaaaatga atcatctggg tgaacttgcc tatattcccc
     8041 agttggacga agtaactctg caggaggaaa aagattttgc gcttgtaggc aagctaggtg
     8101 ttgagcaatt aaatatacag accatgagcg gtggtgaaga aacaaggctt aaaatagcac
     8161 aggccttatc ggcacaggtt catggtattt tagcggatga acctacgagc catttagacc
     8221 gtgaaggaat tgattttcta ataggacagc taaaatattt tacaggtgca ctgttagtta
     8281 ttagccatga ccgctatttt cttgatgaaa tagtagataa aatatgggaa ctgaaagatg
     8341 gcaaaatcac tgagtattgg ggaaactatt ctgattatct tcgtcagaaa gaggaagaac
     8401 gtaagagaca agctgcagaa tacgaacaat ttattgcgga acgtgctcga ttggaaaggg
     8461 ctgcggagga aaagcgaaaa caggctcgta aaatagaaca gaaggcaaaa ggttcttcaa
     8521 agaaaaaaag tactgaaggc ggagggcgtt tagctcatca aaaatcaata ggaagtaagg
     8581 aaaaaaagat gcataatgcc gctaaatccc tagagaacag gattgcggca ttaggaaaag
     8641 tagaagctcc ggaaggcatt cgcagaattc gtttcaggca aagtaaagca ttggagctcc
     8701 ataatccata ccctatagtc ggtgcggaaa ttaataaagt atttggggat aaggcactgt
     8761 ttgaaaatgc atcttttcaa attccgctag gagcaaaagt ggcattaacg ggtggtaatg
     8821 gaaccggaaa aacaacttta atccaaatga tcttaaacca tgaagaagga atttctattt
     8881 cacctaaggc aaaaataggt tactttgcac agaatggtta caagtacaac agtaatcaga
     8941 atgttatgga gtttatgcag aaggattgtg attacaatat atcagaaatt cgttctgtgc
     9001 tagcatctat ggggttcaaa cagaacgata ttggaaaaag cttatctgtt ttaagcggtg
     9061 gagaaattat aaaattgttg cttgctaaaa tgctcatggg tagatataac atcctaataa
     9121 tggatgaacc cagtaacttc cttgacatac caagtttaga ggctttggaa atactaatga
     9181 aggagtacac cggaactatc gtgtttatca cccacgataa acgattactc gaaaatgtag
     9241 ctgatgtagt ttatgaaatt agagataaga aaattaagct gaaacattaa attttaggta
     9301 gtcgctggtc agtatagtct gttctggctg gcgactccat tgttaaagag tataaagact
     9361 tgagatttta tgaagattaa aaataggaac agtaaatcga actgctccta tttttctgct
     9421 aaatatgttg tagttttctt atatgtataa tgatagatta gtggattctc ttctaaggtt
     9481 cttacttcaa atatgaagaa gtgatcgcgg ttatctctgg acttttcctt attgaggaca
     9541 aagtaattct tacgtgaagt cgccattgtt ttgaggatat catcggtcag gaaggtcaat
     9601 ggaatattca tgttggagta gcggtagaag tcacgttcaa aatcttggta gctctcgctg
     9661 taatagtcca tttgcaggtg attacgctga aattcaagct gattcataga gcacctcctc
     9721 tacaagttca atactaacaa tgtctttcaa tttcaaatta atgtgacctg ttgtagtttt
     9781 tatcaaaatg aaatctttgg tcagacttgg tattgttcca gtataggaaa cttgattgtt
     9841 ttttttaaca acatgaatgc gcgtgttcag ttgcccagca tacacctgac tgaggagtaa
     9901 taatttcttc tccagtgaca aatctgacat atacgttact ttgtttgcat cgtcagtgag
     9961 tgctgatgta tgctcagata ggaaaaagcc catccatttt tgcatcttag tatcctggta
    10021 ctctcttgct gactgaaatg gcaagtatga acgatcaatc attttaatcc ctccaatcca
    10081 ccagcggaat gaccgccgat aagtttacta cgttcaatat ttctggaacc ttcggttagg
    10141 acggttcctt tttgaatagc taaaaagcca aactgttctc tgacaacatc aattgctgtc
    10201 tgaagtctat tttctttttc aatttgttct acatcatcaa aaagtgacag tagagtaaag
    10261 ttttcatcta caaagccacc ataagacaca ccgatttgcc tcactgcacc agaggtgtat
    10321 ttctttcgga ataattcaag tacatgacca accattgttt ttggaagatt tgctgggtca
    10381 atttttttct gagcattaat tgattttttc atctcagttc tagaatagcc aatatgaata
    10441 gaaacgacag tagctttttt atgtgccgag cgaagacggt tagccctgac ttaaaaatgg
    10501 gggttgaccg cgaacggaag atttaccaag ccctgtatcc cttgaacata aaagcacata
    10561 ctttggagtt tccgacccac gggattgatc agattgtctg gattttagag gctatcatcc
    10621 caagcttgtt tgtggttgct attattttta tgctcacgca actgtttgca gaaagatatc
    10681 caaatcatct ggatacagct cagttatatc ctttttcaaa agtggcattt gctttatcct
    10741 ctcttggagt tggagtgggc tatgtaagtg tgctgtttat cggaatctgt ggattttctt
    10801 ttctagtggg aagtctgata agtggttttg gacagttaga ttatccctac ccaatttata
    10861 gcttagtgaa tcaagaggta actattggaa agatacaaga tgtgttattt cctggcttgt
    10921 tcttagcttt cttagccttt atcgtcattg tggaagtagt gtacttgatt gcttactttt
    10981 tcaagcaaaa aatgcctgtc ctttttcttt cactcattgg gattgttggc ttattgtttg
    11041 gtatccaaac aattcagcct cttcaaagga ttgcacatct gattcccttt acttacttgc
    11101 gttcagtgga gattttgtct ggaagcttac ctaagcaaat tgataatgtc aatctgaatt
    11161 ggggtatggg gctagtctta cttccttgct tgattatcct tttgttagtg gggattctat
    11221 ttattgaaag ctggggaagt tcacgtaaaa aggaagtttt taataggtct tagcattctt
    11281 ataaggaagt taaggaaaaa ctaacataga gagggaatca acttgattct ctctttttga
    11341 ttcgaaaacc aaaccaaaat acaaacacaa acttttcaaa aaaataactt tttatcttga
    11401 caagagctag aaaacttggt atcatttaaa agttgagaaa agcagaagtg agagcttctc
    11461 gccttgtgac attaagttgc ctggccctac ggatgaaaag tttcgaagaa acgctatcat
    11521 aacgtgcggg cttgtatatt tacgagtccg ctattgtttt tctctaataa aacaaaagag
    11581 gtgaaaacca tagcaaagca agacttattc atcaatgatg agattcgtgt acgtgaagtt
    11641 cgcttgattg gtcttgaggg agaacagcta ggcatcaagc cactcagtga agcgcaagct
    11701 ttggctgata acgctaatgt tgacctagta ttgattcaac cccaagccaa accgcctgtt
    11761 gcaaaaatta tggactacgg taagttcaaa tttgagtacc agaagaagca aaaagaacaa
    11821 cgtaaaaaac aaagcgttgt tactgtgaaa gaagttcgtc taagtccaac aattgacaag
    11881 ggtgactttg atacaaaact tcgtaatgca cgtaagttcc ttgaaaaagg aaataaagtt
    11941 aaggtatcta ttcgctttaa gggtcgtatg attacccata aagagattgg tgcaaaagtt
    12001 ttagccgagt ttgctgaagc aactcaagat attgccatca tcgaacaacg tgctaaaatg
    12061 gatggacgtc aaatgttcat gcaattggcg ccagcgactg acaaaaaata attgtcagaa
    12121 agttaaataa aggagaaaaa atcatgccaa aacaaaaaac acaccgcgca tcagctaaac
    12181 gtttcaaacg tacaggttct ggtggactta aacgtttccg tgcttacact tctcaccgtt
    12241 tccacggaaa aactaagaaa caacgtcgtc atcttcgtaa agcatctatg gtgcattcag
    12301 gagattacaa acgtatcaaa gcaatgctta ctcgcttgaa ataatagctt gactgtaagt
    12361 aaacaattct aggaaatatt tggaggaaat aaaacatggc acgtgttaaa ggtggcgttg
    12421 tatcacgcaa acgtcgtaaa cgtattctta aattagcaaa aggttactat ggagctaaac
    12481 acatcttgtt ccgtactgca aaagaacaag taatgaactc ttactactat gcataccgtg
    12541 accgtcgtca gaaaaaacgt gacttccgca aattgtggat tactcgtatc aatgcggcag
    12601 ctcgtatgaa cggactttca tactcacaat tgatgcatgg tttgaaattg gctgagatcg
    12661 aagttaaccg taaaatgctt gctgacttgg ctgttaacga tgcagtagct ttcacagctc
    12721 ttgcagatgc agctaaagca aaacttggta aataacaact gatgagactg gaacaggatt
    12781 gtccagtctt tttaaaaata aaggagaaag atatggcttc aaaaatgcta cacacttgct
    12841 tacgagtaga aaatcttgaa aaatcaatcg cattttatca agatgctttt ggttttaaag
    12901 aattgcgtcg cagagatttt ccagaccatg ccttcacgat tgtctatcta ggtcttgagg
    12961 gtgatgatta tgagttggag ttgacttata actacgatca cggtccgtat gtggttggtg
    13021 atgggtttgc ccatatcgcc ctcagtacac ctgatcttga ggcacttcat caagaacaca
    13081 gtgcaaaagg ctatgaagtg actgagccaa atggtctacc aggaactaca ccaaactatt
    13141 actttgtcaa agaccctgat ggatataagg tcgaagtcat tcgtgaaaaa taatttcgtg
    13201 caagttaagt agaatattcg ttttctactt gacttttttt agctgaaaga gtatactaat
    13261 aaaaattcaa cctttaaggg gagtccagag agactcacaa ggtgtcagat aaaagaatag
    13321 tgcaattttc tagaggagac tttttgagtg tgctctcttg tgttgtacga ttttaactga
    13381 ggccttgcac tagcaaggtc ttttctttat ctggtcccct taaaatttaa ggaggaaaag
    13441 ttatgaatcc cacatgtaag aagcgtttgg gtgtcattcg gttggaaacc atgaaggtgg
    13501 ttgcacaaga ggaaatcgcg ccagcaatct ttgaattagt cctagaagga gaaatggttg
    13561 aagccatgcg agcaggccaa tttcttcatc tgcgtgtacc agacgatgcc catcttttac
    13621 gtcgtcctat ttcaatttcg tctattgaca aggcaaacaa gcagtgtcac ctcatttatc
    13681 ggattgaggg agctgggact gcaatttttt caaccttaag tcagggagac actcttgatg
    13741 tgatggggcc tcagggaaat ggttttgact tgtctgacct tgatgagcag aatcaggttc
    13801 tccttgttgg tggtgggatt ggtgttccac ccttgcttga ggtggccaag gaattgcatg
    13861 aacgtggagt gaaagtagtg acagtcctcg gttttgctaa taaggatgct gttattttga
    13921 aaacggaatt ggctcagtat ggtcaggtct ttgtaacgac agatgatggt tcttatggca
    13981 tcaagggaaa tgtttccgtt gttatcaatg atttagatag tcagtttgat gctgtttact
    14041 cgtgtggggc tccaggaatg atgaagtata tcaatcaaac ctttgatgat cacccaagag
    14101 cctatttatc tctggaatct cgtatggctt gtgggatggg agcttgctat gcctgtgttc
    14161 taaaagtacc agaaagcgag acggtcagcc aacgcgtctg tgaagatggt cctgttttcc
    14221 gcacaggaac agttgtatta taaggagaaa attatgacta caaatcgatt acaagtgtct
    14281 ctacctggtt tggatttgaa aaatccgatt attccagcat caggttgttt tggttttgga
    14341 caagagtatg ccaagtacta tgatttaaac cttttaggtt ctattatgat caaggcgaca
    14401 acccttgaac cacgttttgg aaatccaact ccaagagtgg cagagacgcc tgctggtatg
    14461 ctcaatgcaa ttggcttgca aaatcctggt ttagaggttg ttttggctga aaagctacct
    14521 tggctggaaa gagaatatcc aaatcttcct attattgcca atgtagctgg tttttcaaaa
    14581 caagagtatg cagctgtttc tcatgggatt tccaaggcaa ctaatgtaaa agctatcgag
    14641 ctcaatattt cttgtcccaa tgttgaccac tgtaatcatg gacttttgat tggtcaagat
    14701 ccagatttgg cttatgatgt ggtgaaagca gctgtggaag cctcagaagt gccagtttat
    14761 gtcaaattaa ccccgagtgt gaccgatatc gttactgtcg caaaagctgc agaagatgcg
    14821 ggagcaagtg gcttgaccat gatcaatact ctggttggaa tgcgctttga cctcaaaacc
    14881 agaaaaccaa tcttggccaa tggaacaggt ggaatgtcag gtccagcagt ctttccagta
    14941 gccctcaaac tcatccgcca agtagcccaa acaacagacc tgcctatcat tggaatgggg
    15001 ggagtggatt cggctgaagc tgccctagaa atgtatctgg ctggggcatc tgctatcgga
    15061 gttggaacag ctaactttac caatccttat gcctgccctg acatcatcga aaatttacca
    15121 aaagtcatgg ataaatacgg tattagcagt ctggaagaac tccgtcagga agtaaaagag
    15181 tctctgaggt aaactacaat caatctgttc ttgatttttt attagtttgt aatatgaatt
    15241 taggagaatt ttggtacaat aaaataaata agaacagagg aagaaggtta atgaagaaag
    15301 taagatttat ttttttagct ctgctatttt tcttagctag tccagagggt gcaatggcta
    15361 gtgatggtac ttggcaagga aaacagtatc tgaaagaaga tggcagtcaa gcagcgaatg
    15421 agtgggtttt tgatactcat tatcaatctt ggttctatat aaaagcagat gctaactatg
    15481 ctgaaaatga atggctaaag caaggtgacg actattttta cctcaaatct ggtggctata
    15541 tggccaaatc agaatgggta gaagacaagg gagcctttta ttatcttgac caagatggaa
    15601 agatgaaaag aaatgcttgg gtaggaactt cctatgttgg tgcaacaggt gccaaagtaa
    15661 tagaagactg ggtctatgat tctcaatacg atgcttggtt ttatatcaaa gcagatggac
    15721 agcacgcaga gaaagaatgg ctccaaatta aagggaagga ctattatttc aaatccggtg
    15781 gttatctact gacaagtcag tggattaatc aagcttatgt gaatgctagt ggtgccaaag
    15841 tacagcaagg ttggcttttt gacaaacaat accaatcttg gttttacatc aaagaaaatg
    15901 gaaactatgc tgataaagaa tggattttcg agaatggtca ctattattat ctaaaatccg
    15961 gtggctacat ggcagccaat gaatggattt gggataagga atcttggttt tatctcaaat
    16021 ttgatgggaa aatagctgaa aaagaatggg tctacgattc tcatagtcaa gcttggtact
    16081 acttcaaatc cggtggctac atggcagcca atgaatggat ttgggataag gaatcttggt
    16141 tttacctcaa gtttgatggc aaaatggctg aaaaagaatg ggtctacgat tctcatagtc
    16201 aagcctggta ctacttcaaa tccggtggtt acatgacagc caatgaatgg atttgggata
    16261 aggaatcttg gttttatctc aaatctgatg ggaaaatagc tgaaaaagaa tgggtctacg
    16321 attctcatag tcaagcttgg tactacttca aatccggtgg ttacatgaca gccaatgaat
    16381 ggatttggga taaggaatct tggttttacc tcaagtctga tggcaaaatg gctgaaaaag
    16441 aatgggtcta cgattctcat agtcaagcct ggtactactt caaatctggt ggctacatgg
    16501 cgaaaaatga gacagtagat ggttatcagc ttggaagcga tggtaaatgg cttggaggaa
    16561 aagctacaaa tgaaaatgct gcttactatc aagtagtgcc tgttacagcc aatgtttatg
    16621 attcagatgg tgaaaagctt tcctatatat cgcaaggcag tgtcgtatgg ctagataagg
    16681 atagaaaaag tgatgacaag cgcttggcta ttactatttc tggtttgtca ggctatatga
    16741 aaacagaaga tttacaagcg ctagatgcta gtaaggactt tatcccttat tatgagagtg
    16801 atggccaccg tttttatcac tatgtggctc agaatgctag tatcccagta gcttctcatc
    16861 tttctgatat ggaagtaggc aagaaatatt attcggcaga tggcctgcat tttgatggtt
    16921 ttaagcttga gaatcccttc cttttcaaag atttaacaga ggctacaaac tacagtgctg
    16981 aagaattgga taaggtattt agtttgctaa acattaacaa tagccttttg gagaacaagg
    17041 gcgctacttt taaggaagcc gaagaacatt accatatcaa tgctctttat ctccttgccc
    17101 atagtgccct agaaagtaac tggggaagaa gtaaaattgc caaagataag aataatttct
    17161 ttggcattac agcctatgat acgacccctt acctttctgc taagacattt gatgatgtgg
    17221 ataagggaat tttaggtgca accaagtgga ttaaggaaaa ttatatcgat aggggaagaa
    17281 ctttccttgg aaacaaggct tctggtatga atgtggaata tgcttcagac ccttattggg
    17341 gcgaaaaaat tgctagtgtg atgatgaaaa tcaatgagaa gctaggtggc aaagattagt
    17401 actataagtg aatatgattt gagtgaatag taagttaaaa atcctgattt caagtaaaat
    17461 caggattttt tcatggatgc aatttttttg gagtctggtg tgacgcggag ggtcttttgt
    17521 cctgtgtaag tgacaaagcc gggttttcca ccagttggtt tattgagttt tttgacttca
    17581 atcatatcta cctgcaccag attcgacagg cgcccttgag agaagtaggc agctaactct
    17641 gctgcgtctg tcttgactgc atcagatggg tcaagatttc ctgagatgac aacatggctt
    17701 ccaggaatgt ccttagcatg gaaccaaagt tcctccttgc gggccatttt aaaggtcaat
    17761 tcctcatttt gaagattgtt tcgtccgaca tagatgatgg ttttgccatc gcttgctaga
    17821 tattgttcta gttttttgcg tttctggatt ttctcccgtt gtcttctgcg gataaaacct
    17881 gtttgaatca attcttcacg gatttcagcg atttcttcca gtccagcttg gttgaggacg
    17941 gtttctacac tttccagata gagaatagtg gctttggttt cttcaatcaa atcagtcaag
    18001 tatttgacag cttctttgag tttctgatac cgtttaaaat agcgttgggc attctggttg
    18061 ggagtcagag ccttatcaag cgcaatcatg ataggttggt tggtatagta gttgtctagg
    18121 ataacctggt cttggtcgtt aggcacttgg tgtaggaagg ttgtcagcaa ttctcctttt
    18181 tgacgaaatt cttcagcgtt gtctgtcgcc agtaactctt tttcctgttt tttgagtttg
    18241 tgtcggtttt tctgaagttc attttcaaca cgacgaatca gttcactggc ctgctgtttg
    18301 acgcggtcgc gctcagcctt atccttatag taggtgtcca acaaatcaga aagatttgca
    18361 aaaggctctc ccacctgatt tgcaaaagga actggactga aggaagtctc agtcaagcat
    18421 ggcttggttt cttgattgaa aaaatttcgg aaagcggaaa gtttttcact aaccagtatc
    18481 ctttccaatt catttgccgt atcgcgtccc agaccttgaa agaggctttg aagatttttt
    18541 gctgttagtt cttgggtttg caggatttca aagagctttt catccttgat agtaaaagga
    18601 ttgagagatt ctgtacttgg cggagcgata taggtcgatc ctggaagtaa ggtgcggtag
    18661 ctattttgtg aaaaaccgac gtgtttgata acttcgagga ttttatgact gcttttatcg
    18721 accagtagaa tattactgtg tttccccata atttcgataa tcaaggtagc ctggatatgg
    18781 tctccaatct cgtttttatt ggaaactgta atttccacaa tacggtcatt ttccacttgc
    18841 tcaatcgact caatcagggc cccctgcaaa tactttctca aaaccatgat aaaggtagaa
    18901 ggttgagctg gattttcaaa agtcgtttgg gtcagctgaa tgcgtccaaa aactggatgg
    18961 gcagaaagga gcaggcgatg gctttggcga ttgctgcgga tttgcaagac caactcttgt
    19021 tcaaaaggct gattgatttt ctggatgcga ccattcacta attcgcttcg caattcctca
    19081 actatgtggt gtaaaaaaaa tccgtcaaat gacatcgttc tctccttgtg attgtattcc
    19141 atagtattat atcaaaaagg tagaataaaa tcatggaaat gtggtataat aaagccaagt
    19201 aaagagaaac gagaagcaca tgtatattga aatggtagat gaaactggtc aagtttcaaa
    19261 agaaatgttg caacaaaccc aagaaatttt ggaatttgca gcccaaaaat taggaaaaga
    19321 agacaaggag atggcagtca cttttgtgac caatgagcgt agtcatgaac ttaatctgga
    19381 gtaccgtaac accgaccgtc cgacagatgt catcagcctt gagtataaac cagaattgga
    19441 aattgccttt gacgaagagg atttgcttga aaattcagaa ttggcagaga tgatgtctga
    19501 gtttgatgcc tatattgggg aattgttcat ctctagcgat aaggctcatg agcaggccga
    19561 agaatatggt cacagctttg agcgtgagat gggcttcttg gcagtacacg gctttttaca
    19621 tattaacggc tatgatcact acactccgga agaagaagcg gagatgttcg gtttacaaga
    19681 agaaattttg acagcctatg gactcacaag acaataaacg aaaatggaaa aatcgtgacc
    19741 tgatatccag tttagaattt gccatcacag ggatttttac tgctatcaag gaagaacgaa
    19801 atatgcgaaa acatgcagtg acggctctag tggtcatcct tgcaggtttt gtttttcagg
    19861 tgtcacgaat cgaatggctc tttctcctat tgagcatttt cttggtagta gcctttgaga
    19921 ttatcaactc tgctattgaa aatatggtgg atttggccag tcactatcac ttttccatgc
    19981 tggctaaaaa tgccaaggat atggcggctg gcgcggtatt agtggtttct cttttcgcag
    20041 ccttaacagg tgcattgatt tttctcccac gaatctggga tttattattt taaacagtaa
    20101 gaggaaatta tgacttttaa atcaggcttt gtagccattt taggacgtcc caatgttggg
    20161 aagtcaacct ttttaaatca cgttatgggg caaaagattg ccatcatgag tgacaaggcg
    20221 cagacaacgc gcaataaaat catgggaatt tacacgactg ataaggagca aattgtcttt
    20281 atcgacacac cagggattca caaacctaaa acagctctcg gagatttcat ggttgagtct
    20341 gcctacagta cccttcgcga agtggacacc gttcttttca tggtgcctgc tgatgaagcg
    20401 cgtggtaagg gggacgatat gattatcgag cgtctcaagg ctgccaaggt tcctgtgatt
    20461 ttggtggtga ataaaatcga taaggtccat ccagaccagc tcttgtctca gattgatgac
    20521 ttccgtaatc aaatggactt taaggaaatt gttccaatct cagcccttca gggaaataac
    20581 gtgtctcgtc tagtggatat tttgagtgaa aatctggatg aaggtttcca atatttcccg
    20641 tctgatcaaa tcacagatca tccagaacgt ttcttagttt cagaaatggt tcgcgagaaa
    20701 gtcttgcacc taactcgtga agagattccg cattctgtag cagtagttgt tgactctatg
    20761 aaacgagacg aagagacaga caaggttcac atccgtgcaa ccatcatggt cgagcgcgat
    20821 agccaaaaag ggattatcat cggtaaaggt ggcgctatgc ttaagaaaat cggtagtatg
    20881 gcccgtcgtg atatcgaact catgctagga gacaaggtct tcctagaaac ctgggtcaag
    20941 gtcaagaaaa actggcgcga taaaaagcta gatttggctg actttggcta taatgaaaga
    21001 gaatactaag tagaggtagg ctcatgcctg cttcttgttt ttacagaagg aggacttatg
    21061 cctgaattac ctgaggttga aaccgtttgt cgtggcttag aaaaattgat tataggaaag
    21121 aagatttcga gtatagaaat tcgctacccc aagatgatta agacggattt ggaagagttt
    21181 caaagggaat tgcctagtca gattatcgag tcaatgggac gtcgtggaaa atatttgctt
    21241 ttttatctga cagacaaggt cttgatttcc catttgcgga tggagggcaa gtatttttac
    21301 tatccagacc aaggacctga acgcaagcat gcccatgttt tctttcattt tgaagatggt
    21361 ggcacgcttg tttatgagga tgttcgcaag tttggaacca tggaactctt ggtgcctgac
    21421 cttttagacg cctactttat ttctaaaaaa ttaggtcctg aaccaagcga acaagacttt
    21481 gatttacagg tctttcaatc tgcccttgcc aagtccaaaa agcctatcaa atcccatctc
    21541 ctagaccaga ccttggtagc tggacttggc aatatctatg tggatgaggt tctctggcga
    21601 gctcaggttc atccagctag atcttcccag actttgacag cagaagaagc gacagctatt
    21661 catgaccaaa ccattgctgt tttgaaccag gctgttgaaa aaggcggttc caccattcgg
    21721 acctatacca atgcctttgg ggaagatgga agcatgcagg attttcatca ggtctatgat
    21781 aagactggtc aagaatgtgt acgctgtggt accatcattg agaaaattca actaggcgga
    21841 cgaggcaccc acttttgtcc aaactgtcaa aggagggact gatgagaaaa atcatcggaa
    21901 tcactggggg aattgcctct ggtaagtcaa ctgtgacaaa ttttctaaga cagcaaggct
    21961 ttcaagcagt ggatgccgac gcagtcgtcc accaactaca gaaacctggt ggtcgtctgt
    22021 ttgaggctct agtacagcac tttgggcaag aaatcattct tgaaaacgga gaactcaatc
    22081 gccctctcct agctagtctc atcttttcaa atcctgaaga gcaaaaatgg tctaagcaaa
    22141 ttcaagggga gattatccgt gaggaactgg ctactttgag agaacagttg gctcagacag
    22201 aagagatttt cttcatggat attcccctac tttttgagca ggactacagc gattggtttg
    22261 ctgagacttg gttggtctat gtggaccgag atacccaagt agaacgctta atgaaaaggg
    22321 accagttgtc caaggatgaa gctgagtctc gtctggcagc ccagtggcct ttagaaaaaa
    22381 agaaagattt ggccagccag gttcttgata ataatggcaa tcagaaccag cttcttaatc
    22441 aagtgcatat ccttcttgag ggaggtaggc aagatgacag agattaactg gaaggataat
    22501 ctgcgcattg cctggtttgg taattttctg acaggagcca gtatttcttt ggttgtacct
    22561 tttatgccca tcttcgtgga aaatctaggt gtagggagtg agcaagtcgc tttttatgca
    22621 ggcttagcaa tttctgtctc tgctatttcc gcggcgctct tttctcctat ttggggtatt
    22681 cttgctgaca aatacggccg aaaacccatg atgattcggg caggtcttgc tatgactatc
    22741 actatgggag gcttggcctt tgtcccaaat atctattggt taatctttct tcgtttacta
    22801 aacggtgtat ttgcaggttt tgttcctaat gcaacggcac tgatagccag tcaggttcca
    22861 aaggagaaat caggctctgc cttaggtact ttgtctacag gcgtagttgc aggtactcta
    22921 actggtccct ttattggtgg ctttatcgca gaattatttg gcattcgtac agttttctta
    22981 ctggttggta gttttctatt tttagctgct attttgacta tttgctttat caaggaagat
    23041 tttcaaccag tagccaagga aaaggctatt ccaacaaagg aattatttac ctcggttaaa
    23101 tatccctatc ttttgctcaa tctcttttta accagttttg tcatccaatt ttcagctcaa
    23161 tcgattggcc ctattttggc tctttatgta cgcgacttag ggcagacaga gaatcttctt
    23221 tttgtctctg gtttgattgt gtccagtatg ggcttttcca gcatgatgag tgcaggagtc
    23281 atgggcaagc taggtgacaa ggtgggcaat catcgtctct tggttgtcgc ccagttttat
    23341 tcagtcatca tctatctcct ctgtgccaat gcctctagcc cccttcaact aggactctat
    23401 cgtttcctct ttggattggg aaccggtgcc ttgattcccg gggttaatgc cctactcagc
    23461 aaaatgactc ccaaagccgg catttcgagg gtctttgcct tcaatcaggt attcttttat
    23521 ctgggaggtg ttgttggtcc catggcaggt tctgcagtag caggtcaatt tggctaccat
    23581 gctgtctttt atgcgacgag cctttgtgtt gcctttagtt gtctctttaa cctgattcaa
    23641 tttcgaacat tattaaaagt aaaggaaatc tagtgcgagt aaaaattaat ctcaaatgct
    23701 cctcttgtga cagtatcaat tacctaacca gtaaaaattc aaaaacccat ccagacaaga
    23761 ttgaggtttt aaagtattgt cccaaggaaa gaaaagtaac cctacatctt gaatctaagt
    23821 agattttatg gtaaaataat agggatttta aggagtttga tatgtataac ctattattaa
    23881 ccattttatt agtattatct gttgtgattg tgattgcaat tttcatgcaa ccaaccaaaa
    23941 accaatccag caatgtattt gatgccagtt caggtgattt gtttgaacgc agtaaagctc
    24001 gcggttttga agctgtaatg cagcgtttga cagggatttt agtctttttc tggctagcca
    24061 ttgccttagc attgacggta ttatcaagta gataagaaaa taatgggcag gactaggtct
    24121 ttgcctcttt ttatttttaa aggatgtttg agaaggtttt acagtaaaag aaaattaaaa
    24181 aatctagaaa gaaaatatga aagatagaat aaaagaatat ttacaagaca agggaaagat
    24241 gactgttaat gatttggctc aggctttggg aaaagacagt tccaaggatt ttcgtgagtt
    24301 gattaaaacc ttgtccttaa tggaaagaaa gcaccaaatt cgttttgaag aagatggtag
    24361 tctgacatta gaaattaaga aaaaacatga gattaccctc aaggggattt ttcatgccca
    24421 taaaaatggc tttggctttg ttagtctgga aggcgaggag gacgaccttt ttgtagggaa
    24481 aaatgatgtc aactatgcta ttgatggtga taccgtcgag gtagtgatta agaaagtcgc
    24541 tgaccgcaat aagggaacag cagcagaagc caaaattatt gatatcctag aacacagttt
    24601 gacaacagtt gtcgggcaaa tcgttctgga tcaggaaaag cctaagtatg ctggctatat
    24661 tcgttcaaaa aatcagaaaa tcagtcaacc gatttatgtt aagaaaccag ccctaaagtt
    24721 agaaggaaca gaagttctca aggtctttat cgataaatac ccaagcaaga aacatgattt
    24781 ctttgtcgcg agtgttctcg atgtagtggg acactcaacg gatgtcggaa ttgatgttct
    24841 tgaggtcttg gaatcaatgg acattgtatc cgagtttcca gaagctgttg ttaaggaagc
    24901 agaaagtgtg cctgatgctc cgtctcaaaa ggatatggaa ggtcgtctgg atctaagaga
    24961 tgaaattacc tttaccattg acggtgcgga tgccaaggac ttggacgatg cagtgcatat
    25021 caaggctctg aaaaatggca atctggagct tggggttcac atcgcagatg tttcttatta
    25081 tgtgaccgag gggtctgccc ttgacaagga agcccttaac cgtgcgactt ctgtttacgt
    25141 gacagaccga gtggtgccaa tgcttccaga acgactatca aatggcatct gctctctcaa
    25201 tccccaagtt gaccgcctga cccagtctgc tattatggag attgataaac atggtcgtgt
    25261 ggtcaactat accattacac aaacagttat caagaccagt tttcgtatga cctatagcga
    25321 tgtcaatgat atcctagctg gcgatgaaga aaagagaaaa gaatatcata aaattgtatt
    25381 aagtatcgaa ctcatggcca agcttcatga aactttagaa aacatgcgtg tgaaacgtgg
    25441 agctctcaat tttgatacca atgaagcgaa gattttagtg gataaacaag gtaagcctgt
    25501 tgatatcgtt cttcggcagc gtggtattgc cgagcggatg attgagtctt ttatgttgat
    25561 ggctaatgaa acagttgccg aacatttcag caagttggat ttgcctttta tctatcgaat
    25621 tcacgaggag cctaaggctg aaaaggttca gaagtttatt gattatgctt cgagttttgg
    25681 cttgcgcatt tatggaactg ccagtgagat tagtcaggag gcacttcaag acatcatgcg
    25741 tgctgttgag ggagaacctt atgcagatgt attgtccatg atgcttcttc gctctatgca
    25801 gcaggctcgt tattcggagc acaatcacgg ccactatgga ctagctgctg actattatac
    25861 tcactttacc agtccaattc gtcgttatcc agaccttctt gttcaccgta tgattcgaga
    25921 ttacggctgt tctaaggaaa tagcagagca ttttgaacaa gtgattccag agattgcgac
    25981 ccagtcttcc aaccgtgaac gtcgtgccat agaagctgag cgtgaagtcg aagccatgaa
    26041 aaaggctgag tatatggaag aatacgtggg tgaagagtat gatgcagttg tatcaagtat
    26101 tgtcaaattc ggtctctttg tcgaattgcc aaacacagtt gaaggcttga ttcacatcac
    26161 taatctacct gaattttatc atttcaatga gcgtgatttg actcttcgtg gagaaaaatc
    26221 aggtatcact ttccgagtgg gtcagcagat ccgtatccgt gttgaaagag cggataaaat
    26281 gactggagag attgattttt cattcgtacc tagtgagttt gatgtgattg aaaaaggctt
    26341 gaaacagtct agtcgtagtg gcagaggtcg tggttcaaat cgtcgttcgg ataagaagga
    26401 agacaagaga aaattaggac gctcaaatga taagcgtaag cattcacaaa aagacaagaa
    26461 gaaaaaagga aagaaacctt tttacaagga agtagctaag aaaggagcca agcatggcaa
    26521 agggcgaggg aaaggtcgtc gcacaaaata aaaaggcacg ccacgactat acaatcgtag
    26581 atacgctaga ggcagggatg gtcctgactg gaactgaaat caagagtgta cgagctgctc
    26641 gaattaatct caaggatggc tttgctcaag tgaaaaatgg agaagtttgg ctgagcaatg
    26701 ttcatatcgc gccttacgaa gagggcaata tctggaacca ggaaccagaa cgtcgtcgta
    26761 aactcctgct tcataaaaag caaattcaaa aattggaaca agagaccaaa gggacaggaa
    26821 tgaccttagt tccccttaag gtctatataa aagatggcta cgctaagctt cttttaggac
    26881 ttgccaaagg gaagcatgac tatgacaaac gggagtctat caaacgtcgt gagcaaaatc
    26941 gagatatcgc gcgtgtgatg aaagctgtta atcagcgata aaaagaggaa ttgaaaatgg
    27001 aaaaatcagt tgcctataaa cgcatgcctt tgtggaataa acaaacaatg cctgaagctg
    27061 ttcagcaaaa gcacaataca aaagttggga cttgggggaa aattactgtc ttgaagggag
    27121 ctctcaagtt tattgaattg acagaagaag gggaagttct agctgaacac ctctttgaag
    27181 caggggcaga caatccaatg gcccaacctc aagcctggca ccgagtggaa gctgccacag
    27241 atgatgtgga atggtacttg gaattttatt gtaaacctga ggattatttt gctaaaaaat
    27301 acaataccaa tcctgttcat tcagaggtcc tagaggccat gcagacagtg aaacaaggga
    27361 aagctttgga tttgggttgt ggtcaggggc gtaattctct ttttctagcc cagcaagatt
    27421 ttgatgtgac ggctgtagat caaaatggac tagctcttga aatcttgcaa agcattgtgg
    27481 agcaggaaga tttggacatg cctgttggcc tttacgatat caattcagct agcattgaac
    27541 aagaatatga ttttatcgtt tcaacagttg ttctcatgtt tctacaagcg gaccgcattc
    27601 cagctattat tcaaaatatg caggagaaaa ccagtgttgg tggttacaac cttatcgttt
    27661 gtgccatgga cacggaggat tatccttgct cggttaactt cccattcacc tttaaagaag
    27721 gagaactggc agactattac aaggattggg aattggttaa gtacaatgaa aatccaggcc
    27781 atttgcaccg tcgcgatgag aatggcaatc gtattcaact acgctttgcg accttactag
    27841 ctaagaaaat caagtaaaca cacatgaaga ttaggaattt tcctgatctt ttttcttttt
    27901 tacgaatgat atagaaaagg agggaattca tgtttgttgc gagagatgct aggggagaat
    27961 tggtaaatgt gttagaggat aaacttgaga agcaagcata cacctgccca gcttgtggag
    28021 gccagatcca tttgcgtcaa ggaccaagtg tacggacgca ttttgcccat aaatccttaa
    28081 aagactgtga ttttttcttt gaaaatgaaa gtccagaaca catagccaat aaggaatccc
    28141 tctatcactg gttgaaaaaa gagacaaagg ttcaattaga gtacccgctt tcagaactta
    28201 aacagattgc ggatgtattt gtaaatggca atctagctct agaagttcag tgtagtccct
    28261 tgcctcagaa agtccttaaa gagcgaagtg agggctatcg tagtcagggt taccaagtac
    28321 tgtggttgct gggtcaaaaa ctgtggctca aggagcgttt gactcgtcta cagcaaggtt
    28381 ttctttattt cagtcaaaac atgggctttt atgtttggga attagacaag gaaaaacaag
    28441 ttttaagact caaatacctg atttaccagg atctccgcgg taaactccat tatcaaatca
    28501 aggaattttc ctatggtcaa ggtagtttat tggaaatatt gcgtcttccc tataagagac
    28561 aaaaaatatc tcattttaca gtttctgagg acaaggacat ctgtcgctat atccggcaac
    28621 aactttatta tcaaaatctc ttttggatga aagaacaagc agaagcctat caaaagggag
    28681 aaaatatcct gacttatgga ctgaaagaat ggtatccaca aattcgacca atagtgggca
    28741 aatttttcca gattgaacaa gacttgacta gctattatca gcacttttat acctattacc
    28801 aaaaaaatcc tcaaaatgat tggcaaaagc tttatccacc agccttttat cagcaatatt
    28861 tcttgaaaaa tatggtagaa tagaaaggat ggaggaatct aatggtatta caaagaaatg
    28921 aaataaatga aaaagataca tgggatctat caacgatcta cccaactgac caggcttggg
    28981 aagaagcctt aaaagattta acagaacaat tggagacagt agcccagtat gaaggccatc
    29041 tcttggatag tgcggataac ctactagaaa tcactgaatt ttctcttgaa atggaacgcc
    29101 agatagagaa gctttacgtt tatgctcata tgaagaatga ccaggataca cgtgaagcta
    29161 agtatcaaga gtactatgcc aaggccatga cactctacag ccagttagac caagcctttt
    29221 cattctatga gcctgaattt atggagatta gcgaaaagca gtatgctgac tttttagaag
    29281 ctcaaccaaa gctgcaggtt tatcaacact attttgacaa gctcttgcaa ggcaaggatc
    29341 acgttctttc acaacgtgaa gaagaattat tggctggagc tggagaaatc tttggttcag
    29401 caagtgaaac cttcgctatc ttggacaatg cggatattgt gttcccttat gtcctagacg
    29461 atgatggtaa agaagttcag ctatctcatg ggacttacac acgtttgatg gagtctaaaa
    29521 aacgtgaggt tcgccgtggt gcctatcaag ctctttatgc gacttacgaa caattccaac
    29581 acacctatgc caaaaccttg caaaccaatg ttaaggtgca aaattaccgt gctaaagttc
    29641 gtaactacaa gagtgctcgt catgcagccc tcgcagcgaa ttttgttcca gaaagtgttt
    29701 atgacaattt ggtagcagca gttcgcaagc atttgccact cttacatcgc tatcttgagc
    29761 ttcgttcaaa aatcttgggg atttcagatc tcaagatgta cgatgtctac acaccgcttt
    29821 catctgttga atacagtttt acctaccaag aagccttgaa aaaagcagaa gatgctttgg
    29881 cagtcttggg tgaggattac ttgagccgtg ttaaacgtgc cttcagcgag cgttggattg
    29941 atgtttacga aaatcgaggc aagcgttcag gtgcctactc tggtggttct tacgatacca
    30001 atgcctttat gcttctcaac tggcaggaca atctggacaa tctctttact cttgttcatg
    30061 aaacaggtca cagtatgcat tcaagctata ctcgtgaaac tcagccttat gtttacggag
    30121 attactctat ctttttggct gagattgcct caactaccaa tgaaaatatc ttgacggaga
    30181 aattattgga agaagtggaa gacgacgcaa cacgctttgc tattctcaat aacttcctag
    30241 atggtttccg tggaacaatt ttccgccaaa ctcaatttgc tgagtttgaa cacgccattc
    30301 accaagcaga tcaaaatggg gaggtcttga caagcgattt cctaaataaa ctctacgcag
    30361 acttgaacca agagtattat ggtttgagta aggaagacaa tcctgaaatc caatacgagt
    30421 gggctcgcat tccacacttc tactataact actatgtata tcaatattca actggctttg
    30481 cggccgcctc agccttggct gaaaaaattg tccatggtag tcaagaagac cgtgaccgct
    30541 atatcgacta cctcaaggca ggtaagtcgg actatccact taatgtcatg agaaaagctg
    30601 gtgttgatat ggagaaggaa gactacctca acgatgcctt tgcagtcttt gaacgccgtt
    30661 taaatgagtt tgaagccctt gttgaaaaat taggattggc ataaaatggt tgaatcgtat
    30721 agtaagaatg ctaaccataa catgcgtcgt cctgtcgtca aagaagaaat tgtagacttg
    30781 atgcgtcagc gtcaaaagca ggtcacaggt ttcttgaaag aattggaaga ctttgcccgc
    30841 aaggaaaata ttcctattat tccccatgaa acggttgctt atttccgttt tattatggaa
    30901 accatgcagc ctaaaaatat tctggaaatt gggacggcta tcggtttttc agctctcttg
    30961 atggctgaac atgcgccaaa tgctaagatt acaactattg atcgtaatcc agaaatgatt
    31021 ggttttgcca aggaaaattt tgcccagttt gacagtcgca agcaaatcac tctcctagag
    31081 ggagatgcgg tggatgtctt atctacactg acagagtctt atgatttcgt atttatggat
    31141 tctgccaagt ctaaatacat cgtctttctg ccagaaatcc tcaaacattt ggaagttggt
    31201 ggtgtggttg tcttggatga tatttttcaa ggtggtgatg ttgccaagga tattatggaa
    31261 gtccgtcgtg gtcagcgaac catttatcga ggccttcaaa aattatttga tgcaacctta
    31321 gacaatccag aactcaccgc aacattagtg cctttaggag atggtattct catgcttcgt
    31381 aaaaatgtag cagatgttca actgtctgaa agcgaatgat tttcagaaaa atttaagaaa
    31441 aaatagtaaa atagatagag taacacttat ctcaaaggag tagacatgaa gaaaaaatta
    31501 ttggcaggtg ccatcacact attatcagta gcaactttag cagcttgttc gaaagggtca
    31561 gaaggagcag accttatcag catgaaaggg gatgtcatca cagaacatca attttatgag
    31621 caagtgaaaa acaacccttc agcccaacaa gtcttgttaa atatgaccat ccaaaaagtt
    31681 tttgaaaaac aatatggctc agagcttgat gataaagagg ttgatgatac tattgccgaa
    31741 gaaaaaaaac aatatggcga aaactaccaa cgtgtcttgt cacaagcagg tatgactctt
    31801 gaaacacgta aagctcaaat tcgtacaagt aaattagttg agttggcagt taagaaggta
    31861 gcagaagctg aattgacaga tgaagcctat aagaaagcct ttgatgagta cactccagat
    31921 gtaacggctc aaatcatccg tcttaataat gaagataagg ccaaagaagt tctcgaaaaa
    31981 gccaaggcag aaggtgctga ttttgctcaa ttagccaaag ataattcaac tgatgaaaaa
    32041 acaaaagaaa atggtggaga aattaccttt gattctgctt caacagaagt acctgagcaa
    32101 gtcaaaaaag ccgctttcgc tttagatgtg gatggtgttt ctgatgtgat tacagcaact
    32161 ggcacacaag cctacagtag ccaatattac attgtaaaac tcactaagaa aacagaaaaa
    32221 tcatctaata ttgatgacta caaagaaaaa ttaaaaactg ttatcttgac tcaaaaacaa
    32281 aatgattcaa catttgttca aagcattatc ggaaaagaat tgcaagcagc caatatcaag
    32341 gttaaggacc aagccttcca aaatatcttt acccaatata tcggtggtgg agattcaagc
    32401 tcaagcagta gtacatcaaa cgaatagtcc aaatcaatga gtcagggaaa aaactcgact
    32461 tcaggaaaaa atgaagcaaa cattcccaca ataaaacgca tagtacaagg tttgtactgc
    32521 cccccaaaaa agttagacaa ttaatttatc cgaaggattt agttctgtat tgcacagagc
    32581 taagtccttt tagttttatc ttaattctct tattgttgta ataatcaata tagtctataa
    32641 tggcttgttc caattgatta agtgatttaa atgtttgctc atagccataa aacatttcgg
    32701 attttaaaat gccaaagaaa gattccatcc taccgttgtc ttggctgttt cctttgcgtg
    32761 acatagatgc ttgaattccc ttactctcta ggaagcgatg ataagaatcg tgttggtatt
    32821 gccagccttg gtcactatgg agaatcgtat tctcgtagtg cttctctttg aatgcctgtt
    32881 ccaacattaa cgatcaatca atttaatcat
//
LOCUS       DAVLHC010000022        31584 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.022, whole genome shotgun sequence.
ACCESSION   DAVLHC010000022 DAVLHC010000000
VERSION     DAVLHC010000022.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 31584)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 31584)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..31584
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.022"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            314..574
                     /locus_tag="VXE25_001138"
     CDS             314..574
                     /locus_tag="VXE25_001138"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810173.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771610.1"
                     /translation="MTGVSNPTTDSARLVLAEAKKAFADDSLTEQGLRDILQTVKDAI
                     ASLESIKESQSATKDGGQTAGKETAGEDESANQTQEISQGIK"
     gene            528..749
                     /locus_tag="VXE25_001139"
     CDS             528..749
                     /locus_tag="VXE25_001139"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771611.1"
                     /translation="MSLQIKLKKLAKELSKLLKDSNLETVDKDVLENSQKELQKAVLF
                     LADEKGSEHTEAEVIDNLKEVIAKLKANA"
     gene            1068..1997
                     /locus_tag="VXE25_001140"
     CDS             1068..1997
                     /locus_tag="VXE25_001140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000714575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEV0771612.1"
                     /translation="MKKFSKTLRDNWIFLLMVLPGALWLILFFYIPVFGNVVAFKDYH
                     MTSNGFIDSIINSKWVGLDNFRFLFSSRDAFIITRNTVLYNLGFIFLGLVVSVGIAII
                     LSELRSKRMVKIFQTSMLFPYFLSWVIISFFTDAFLNIDKGVFNHLLESLGLKEVNFY
                     ADLGIWPYLLLFLGIWKGFGYSSVMYYATIMGIDPTYYEAATVDGASKWQRIRNVTIP
                     QLTPLVTVLTILAVGNIFRADFGLFYQIPHNAGQLYNVTNVLDVYVFNGLTQTADIGM
                     AAAAGLYQSVVGLILVILSNLLARRVDPNSALF"
     gene            2011..2934
                     /locus_tag="VXE25_001141"
     CDS             2011..2934
                     /locus_tag="VXE25_001141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001075101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HEV0771613.1"
                     /translation="MAKKKIKKEKIDNVGIHSFSKKADIFFSIISGLIALSCILPFVF
                     VIIISVTDEKSLLQYGYSFFPSQFGLDGFEFLAQFKDKILQALFISVFVTVVGTLTNV
                     FITTTYAYAISRTTFKYRRFFTIFVLLSMLFNAGLVPGYIMVTRVLQLGDTVWALIVP
                     MLLSPFNIILMRSFFKKTIPEAILESARIDGASEARIFFQICLPLSLPGIATITLLTA
                     LGFWNDWFNALLYIKSDNLYPLQYLLMQIQQNMDYIAKAVGLTGQLGVALPKETGRMA
                     MVVVATLPIAILYPFFQRYFVKGLTIGGVKE"
     gene            3192..4667
                     /locus_tag="VXE25_001142"
     CDS             3192..4667
                     /locus_tag="VXE25_001142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000800432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3502 domain-containing protein"
                     /protein_id="HEV0771614.1"
                     /translation="MKNWKKYAFTSASVVALAAGLAACGNLTGNSKKAADSGDKPVIK
                     MYQIGDKPDNLDELLANANKIIEEKVGAKLDIQYLGWGDYGKKMSVITSSGENYDIAF
                     ADNYIVNAQKGAYADLTELYKKEGKDLYKALDPAYIKGNTVNGKIYAVPVAANVASSQ
                     NFAFNGTLLAKYGIDISGVTSYETLEPVLKQIKEKAPDVVPFAIGKVFIPSDNFDYPV
                     ANGLPFVIDLEGDTTKVVNRYEVPRFKEHLKTLHKFYEAGYIPKDVATSDTSFDLQQD
                     TWFVREETVGPADYGNSLLSRVANKDIQIKPITNFIKKNQTTQVANFVISNNSKNKEK
                     SMEILNLLNTNPELLNGLVYGPEGKNWEKIEGKENRVRVLDGYKGNTHMGGWNTGNNW
                     ILYINENVTDQQIENSKKELAEAKESPALGFIFNTDNVKSEISAIANTMQQFDTAINT
                     GTVDPDKAIPELMEKLKSEGAYEKVLNEMQKQYDEFLKNKK"
     gene            4939..5925
                     /locus_tag="VXE25_001143"
     CDS             4939..5925
                     /locus_tag="VXE25_001143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001030014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-related sulfurtransferase"
                     /protein_id="HEV0771615.1"
                     /translation="MAKDIRVLLYYLYTPIENAEQFAADHLAFCKSIGLKGRILVADE
                     GINGTVSGDYETTQKYMDYVHSLPGMEELWFKIDEESEQAFKKMFVRYKKEIVHLGLE
                     DNDFDNDINPLETTGAYLSPKEFKEALLDKDTVVLDTRNDYEYDLGHFRGAIRPDIRN
                     FRELPQWVRDNKEKFMDKRVVVYCTGGVRCEKFSGWMVREGYKDVGQLHGGIATYGKD
                     PEVQGELWDGKMYVFDERIAVDVNHVNPTIVGKDWFDGTPCERYVNCGNPFCNRRILT
                     SEENEDKYLRGCSHECRVHPRNRYVSKNELTQAEVIERLAAIGESLDQAATV"
     gene            6047..6907
                     /locus_tag="VXE25_001144"
     CDS             6047..6907
                     /locus_tag="VXE25_001144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4299 domain-containing protein"
                     /protein_id="HEV0771616.1"
                     /translation="MAKTFFIPNKQSILGEQEILNAKSILALLDGLESHSYDVVYLRQ
                     PLNRLEYIECAIVGQSQFLFKVSYADGQKAYRVDLPDLLTKTDWQIIKSFLDALLAYT
                     GTDIEGLDGFDFEAYFQASIQAYLADPVARFTICQGIFNPIFFSRENLKSFLEADGLA
                     QFEARVRAVQETDAYFARVSFYQDGEGKVHGVYHLAQGVKTVLPREPFVPAAYIEQLV
                     DKEVQWEIDLVQITGDGSKPEDYEAIARLDYAKFLEVLPLSFYHQLDANQIEVQPILD
                     KDFKALAQEE"
     gene            complement(7085..8149)
                     /locus_tag="VXE25_001145"
     CDS             complement(7085..8149)
                     /locus_tag="VXE25_001145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000808437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771617.1"
                     /translation="MKQEWFESNDFVKTTSKNKPEEQAQEVADKAEETIADFDTPIGK
                     NTQVEEEVSQAEVELESQQEEKIETPEVGEARTEIEEKKASNSTEEESDLSKETEKVT
                     IAEESQEALPQQKATTKEPLLISKSLESPYIPDQAPKSRDKWKEQVLDFWSWLVEAIK
                     SPTSKLETSITHSYTAFLLLILFSASSFFFSIYHIKHAYYGHIASINSRFPEQLAPLT
                     LFSIVSILVATTLFFFSFLLGSFVVRRFIHQEKDWTLDKVLQQYSQLLAIPIFLTAIA
                     SFFAFFDSLRFTALLCVISIGIILLASLHIITRPSQASETDSFYQLFLSVLVNGVIIL
                     LFFVAEVALIGDYLRILAFL"
     gene            complement(8211..9122)
                     /locus_tag="VXE25_001146"
     CDS             complement(8211..9122)
                     /locus_tag="VXE25_001146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001233690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4097 domain-containing protein"
                     /protein_id="HEV0771618.1"
                     /translation="MRKWTKGFLIFGVVTTVIGFILLFVGIQSDGIKSLLSMSKEPVY
                     DSRTEKLTFGKEVENLEITLHQHTLTITDSFDDQIHISYHPSLSAHHDFITNQNDRTL
                     SLTDKKLSETPFLSSGIGGILHIASSYSSRFEEVILRLPKGRTLKGINISANRGQTTI
                     INASLENATLNTNSYILRIEGSRIKNSKLTTPNIVNIFDTVLTDSQLESTDNHFHAEN
                     IQVHGKVELTAKDYLRIILDQKESQRINWDISSNYGSIFQFTREKPESRGTELSNPYK
                     TEKTDVKDQLIARSDDNIDLISTPSRR"
     gene            complement(9115..9708)
                     /locus_tag="VXE25_001147"
     CDS             complement(9115..9708)
                     /locus_tag="VXE25_001147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000198695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1700 domain-containing protein"
                     /protein_id="HEV0771619.1"
                     /translation="MTRTEYLTQLELYLKKLPEADRIEAMDYFRELFDDAGVEGEEEL
                     IASLGTPKEAAHEVLSNLLDKKINEAPAQKNNRQILHIALLALLAAPIGIPLGIAILV
                     TLFAILVAALTVILAFFAVSILGIIGGFLFLVESFTILAQAKSAFILIFGSGLLAIGA
                     SSLVLLGISYVARFFGLLIVRLVQFVLKKGKRGNQHA"
     gene            complement(9695..10021)
                     /locus_tag="VXE25_001148"
     CDS             complement(9695..10021)
                     /locus_tag="VXE25_001148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000273865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="HEV0771620.1"
                     /translation="MYFPTSSALIEFLILAVLEQGDSYGYEISQTIKLIANIKESTLY
                     PILKKLEGNSFLTTYSREFQGRMRKYYSLTNGGIEQLLTLKDEWTLYTDTINGIIEGS
                     IRHDKN"
     gene            complement(10160..11326)
                     /locus_tag="VXE25_001149"
     CDS             complement(10160..11326)
                     /locus_tag="VXE25_001149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CynX/NimT family MFS transporter"
                     /protein_id="HEV0771621.1"
                     /translation="MKKQSLFFVPGIILIGVSLRTPFTVLPIILGNISQGLEVEVSSL
                     GVLTSLPLLMFTLFSPFSTRLAQKIGLEHLFTYSLFFLTIGSLIRLINLPLLYLGTLM
                     VGASVAVINVLLPSLIQANQPKKIGFLTTLYVTSMGIATALASYLAVPITQASSWKGL
                     ILLLTLLCLATFLVWLPNHRYNHRLAPQTKQKSQIKVMRNKQVWAIIIFSGFQSLIFY
                     TVMTWLPTMSIHAGLSSHEAGLLTSILSLISIPFSMTIPSLTTSLSTRNRQLMLTLVS
                     LAGVVGISMLFFPINNFIYWLTIHLLIGTATSALFPYLMVNFSLKTSAPEKTAQLSGL
                     SQTGGYILAAFGPTLFGYSFDLFHSWVPAVAALLLIYILMTVALFTVDRADKIL"
     gene            11384..12541
                     /locus_tag="VXE25_001150"
     CDS             11384..12541
                     /locus_tag="VXE25_001150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000096189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HEV0771622.1"
                     /translation="MSSKVSGFQDKNGKVLKIMIEWWKEKFRRVVVTQNVESLLVSIV
                     ISAYNEEKYLPGLIEDLKNQTYPKENIEILFINAMSTDGTTAIIQQFIKEDTEFNSIR
                     LYNNPKKNQASGFNLGVKHSVGDLILKIDAHSKVTESFVMNNVAIIQQGEFVCGGPRP
                     TIIEGKGKWAETLHLVEENMFGSSIANYRNSSEDRYVSSIFHGMYKREVFQKVGLVNE
                     QLGRTEDNDIHYRIREYGYKIRYSPSILSYQYIRPTFKKMLHQKYLNGLWIGLTSHVQ
                     FKCLSLFHYVPCLFVLSLVFSLALLPITFVFITLLLGAYFLLLSLLTLLTLLKHKNGF
                     LIVMPFLLFSIHFAYGFGTIVGLIRGFKWKKEYKRTIIYLDKISQINKNML"
     gene            12583..14433
                     /locus_tag="VXE25_001151"
     CDS             12583..14433
                     /locus_tag="VXE25_001151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001035735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis protein"
                     /protein_id="HEV0771623.1"
                     /translation="MNKKLTDYVIDLVEILNKQQKQVFWGIFDIFSMVVSIIVSYILF
                     YGLINPAPVDYIIYTSLAFLFYQLMIGFWGLNASISRYSKITDFMKIFFGVTASSVLS
                     YSICYAFLPLFSIRFIILFILLSTFLILLPRITWQLIYSRRKKGSGDGEHRRTFLIGA
                     GDGGALFMDSYQHPTSELELVGILDKDSKKKGQKLGGIPVLGSYDNLPELAKRHQIER
                     VIVAIPSLDPSEYERILQMCNKLGVKCYKMPKVETVVQGLHQAGTGFQKIDITDLLGR
                     QEIRLDESRLGAELTGKTILVTGAGGSIGSEICRQVSRFNPERIVLLGHGENSIYLVY
                     HELIRKFQEIDYVPVIADIQDYDRLLQVFEQYKPAIVYHAAAHKHVPMMERNPKEAFK
                     NNIRGTYNVAKAVDEAKVSKMVMISTDKAVNPPNVMGATKRVAELIVTGFNQRSQSTY
                     CAVRFGNVLGSRGSVIPVFERQIAEGGPVTVTDFRMTRYFMTIPEASRLVIHAGAYAK
                     DGEVFILDMGKPVKIYDLAKKMVLLSGHTESEIPIVEVGIRPGEKLYEELLVSTELVD
                     NQVMDKIFVGKVNVMPLESINQKIGEFRTLSGDELKQAIIAFANQTTHIE"
     gene            complement(14615..14713)
                     /locus_tag="VXE25_001152"
                     /pseudo
     CDS             complement(14615..14713)
                     /locus_tag="VXE25_001152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            complement(14739..15371)
                     /locus_tag="VXE25_001153"
     CDS             complement(14739..15371)
                     /locus_tag="VXE25_001153"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000200889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HEV0771624.1"
                     /translation="MTSITAIFFDLDGTLVDSSIGIHNAFTYTFKELGVPSPDAKTIR
                     GFMGPPLESSFATCLSKDQISEAMQIYRSYYKAKGIYEAQLFPQIIDLLEELSSSYPL
                     YITTTKNTSTAQDMAKNLEIHHFFDGIYGSSPEAPHKADVIHQALQTHQLAPEQAIII
                     GDTKFDMLGARETGIQKLAVTWGFGEQADLLNYQPDYIAHKPLEVLAYFQ"
     gene            complement(15393..16265)
                     /gene="sdaAA"
                     /locus_tag="VXE25_001154"
     CDS             complement(15393..16265)
                     /gene="sdaAA"
                     /locus_tag="VXE25_001154"
                     /EC_number="4.3.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000500050.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-serine ammonia-lyase, iron-sulfur-dependent,
                     subunit alpha"
                     /protein_id="HEV0771625.1"
                     /translation="MFYSIKELVEQADLDFQGNVAELMITTEFELTGREREEVFLLME
                     RNLEVMKASVQLGLNENKSRSGLTGGDAAKLDHYIKNEKTLSDYTILSAARNAIAVNE
                     HNAKMGLVCATPTAGSAGCLPSVLTAAIEKLDLSHEQQLDFLFAAGAFGLVIANNASI
                     SGAEGGCQAEVGSASAMSAAALTLAAGGTPYQASQAIAFVIKNMLGLICDPVAGLVEV
                     PCVKRNAMGASFAFIAADMALAGIESKIPVDEVIDAMYQVGASMPTAFRETAEGGLAT
                     TPTGRRLQKEIFGE"
     gene            complement(16274..16945)
                     /gene="sdaAB"
                     /locus_tag="VXE25_001155"
     CDS             complement(16274..16945)
                     /gene="sdaAB"
                     /locus_tag="VXE25_001155"
                     /EC_number="4.3.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606087.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-serine ammonia-lyase, iron-sulfur-dependent
                     subunit beta"
                     /protein_id="HEV0771626.1"
                     /translation="MKSLRFQSVFDIIGPVMIGPSSSHTAGAVRIGKIVSSIFDDTPT
                     EVEFQLFNSFAKTYRGHGTDLALVAGILGMDTDDPEIPNSLEIAHKRGIKIVWTIQKD
                     SNAPHPNTTKITVKNAHKTISVTGISIGGGNIQVTELNGFAVSLNMNTPTIIIVHQDI
                     PGMIALVTEALSRYGINIAQMNVTREKAGEKAIMIIEVDSRNCDEAIEEIRKIPHLHN
                     VNFFK"
     gene            17187..17759
                     /locus_tag="VXE25_001156"
     CDS             17187..17759
                     /locus_tag="VXE25_001156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="HEV0771627.1"
                     /translation="MKSITKKIKATLAGVAALFAVFAPSFVSAQESSTYTVKEGDTLS
                     EIAETHNTTVEKLAENNHIDNIHLIYVDQELVIDGPVAPVATPAPATYAAPAAQDETV
                     SAPVVSETVVSTVSGSEAEAKEWIAQKESGGSYTATNGRYIGRYQLTDSYLNGDYSAE
                     NQERVADAYVAGRYGSWTAAKNFWLNNGWY"
     gene            complement(17812..18132)
                     /locus_tag="VXE25_001157"
     CDS             complement(17812..18132)
                     /locus_tag="VXE25_001157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861316.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HEV0771628.1"
                     /translation="MQRLEVYKNYQHLYDLRIAILLNLSTLYLYNQDKNMCKQICYTL
                     LEDAKNKKSYDRLAICYVRIGICTDNAKLIQKGFSLLELTEETSMLSHLKKEVETHYQ
                     PKKL"
     gene            18557..18844
                     /locus_tag="VXE25_001158"
     CDS             18557..18844
                     /locus_tag="VXE25_001158"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001230165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="HEV0771629.1"
                     /translation="MRKLVKIGVASLMVCGILATTNALAVWVEGGQWNYGVGWTGTFG
                     YSDYLHSTRYHTATVRHGGRTSKDYAKPEAWARASLTKIPPTGMEYFYGFE"
     gene            18896..21004
                     /locus_tag="VXE25_001159"
     CDS             18896..21004
                     /locus_tag="VXE25_001159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000723955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="HEV0771630.1"
                     /translation="MKKISNFCMLLLLLCTTFFVFNVNYTREVVRIQEMGKTVDSLDL
                     YLKDINEPAASVLRFFEDVSKEYKVSIIKTDSGDEVVKSGVFDKDTFPYQEFGISSLD
                     FTTDGEGVYSNKEISNKLGTIPTFLKAKPIQLMTFQTYIKDTSRSLNGRYTITSTQEM
                     DKDRIVQKWSDFFKIDQATLLEPTYKSAVEVINRDLLLSAIVFVLAILLLVLVTVYQP
                     MMEMKRVGVQKLLGFQDRAVLADVVKGNLYLLLGGALVINLGVFFLLDYKPKDLFPML
                     WLSHFLLLQLYLFISWLTYLLIQKMTISSLLKGFSSFKFGLIFNYVMKIGTTILLTAL
                     LIGVGRSLEQENKELAYQQQWVSQGNYLTLETFKLNDNLWQEELAGSGKSTDYFYRFY
                     QDLVEKTQAGYVQSSSLPVKNFVQSEQIQQYQLTDTVDVYYANRNFLKSKGFKLPDTG
                     IKKVILMPASTKGEEDKNQLLGKLIAFHSMKYEEQQKRTIEEMDVEIAYYEGDWSFFP
                     YSDKRKENLSNPIISLVNDSDMMWDEKASLSTTGLNNPIKIENTVQHQKEITELVEKL
                     SDGNYLKFSSIQAIQQEKVDSYRDAVRNFNLLFALFGLLSMMISYFLLVTTFLLKRRD
                     IITKKFMGWKLVDRYRPLLVLLLLGYSFPLLVLIFFAHAFLPLLLFAGFTCLDILFVL
                     GLASRMEKRSLVELLKGGIL"
     gene            21001..21642
                     /locus_tag="VXE25_001160"
     CDS             21001..21642
                     /locus_tag="VXE25_001160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000571330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0771631.1"
                     /translation="MIELKNITKTIGGKVILDNLSLRIDQGDLVAIVGKSGSGKSTLL
                     NLLGLIDGDYSGRYEIFGQTNLAVNSAKSQTIIREHISYLFQNFALIDDETVEYNLML
                     ALKYVKLPKKDKLKKVEEILERVGLSATLHQRVSELSGGEQQRIAVARAILKPSQLIL
                     ADEPTGSLDPENRDLVLKFLLEMNREGKTVIIVTHDAYVAQQCHRIIELGEGK"
     gene            21849..22655
                     /locus_tag="VXE25_001161"
     CDS             21849..22655
                     /locus_tag="VXE25_001161"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001038484.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HEV0771632.1"
                     /translation="MNKMKKVLMTMFGLVMLPLLFACSNNQSAGIEAIKSKGKLVVAL
                     NPDFAPFEYQKVVDGKNQIVGSDIELAKAIATELGVELELSPMSFDNVLASVQSGKAD
                     LAISGVSKTDERSKVFDFSTPYYTAKNKLIVKKSDLATYQSVNDLAQKKVGAQKGSIQ
                     ETMAKDLLQNSSLVSLPKNGNLITDLKSGQVDAVIFEEPVAKGFVENNPDLAIADLNF
                     EKEQDDSYAVAMKKDSKELKEAVDKTIQKLKESGELDKLIEDAFKASIEK"
     gene            22672..23868
                     /locus_tag="VXE25_001162"
     CDS             22672..23868
                     /locus_tag="VXE25_001162"
                     /EC_number="6.3.4.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000031904.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="argininosuccinate synthase"
                     /protein_id="HEV0771633.1"
                     /translation="MSKEKVILAYSGGLDTSVAITWLKKDYDVVAVCMDVGEGKDLDF
                     IHDKALKVGAVESYVIDVKDEFATDYVLVALQSHAYYEQKYPLVSALSRPLISKKLVE
                     IAHQTGATTIAHGCTGKGNDQVRFEVSIAALDLNLKVIAPVREWKWSREEEIYYAKEN
                     GVPVPADLDNPYSVDQNLWGRANECGILENPWNQAPEEAFGITTSPEQAPDMPEYIEI
                     EFSEGVPVSLNGEVLKLADLIQKLNEIAGKHGVGRIDHVENRLVGIKSREIYECPGAV
                     TLLTAHKEIEDLTLVREVAHFKPIIENELSNLIYNALWFSSATQALIAYIKETQKVVN
                     GTAKVKLYKGSAQVVARKSPNSLYDENLATYTSADTVDQDAAVGFIKLWGLPTKVHSE
                     VQKSAK"
     gene            23928..24716
                     /gene="argH"
                     /locus_tag="VXE25_001163"
                     /pseudo
     CDS             23928..24716
                     /gene="argH"
                     /locus_tag="VXE25_001163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001107608.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="argininosuccinate lyase"
     gene            complement(25005..25868)
                     /locus_tag="VXE25_001164"
     CDS             complement(25005..25868)
                     /locus_tag="VXE25_001164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001268160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEV0771634.1"
                     /translation="MRYDFGKVYKEIRESKGLTQEEVCGGVLSRTSLSKIESGKTTPK
                     YENMEFLLRQINMSFEEFEYICQLYQPSQRTEIMQTYLNMRSIIGTSDLVNLFQKCQD
                     YLKTHHDLPIEEIRDMLEVVIYLRQHGAGELSKHAEQVVKKLWKKIEKQDTWYESDLK
                     ILNTILFSFPIEYLHLITGKILQRLEVYKNYQHLYDLRMTILLNLSTLYLYNQDKNMC
                     KQICYTLLEDAKNKKSYDRLAICYVRIGICRDDAKLIQKGFSLLELTEETSILSHLKK
                     EVEIYYQAKER"
     gene            26334..28553
                     /locus_tag="VXE25_001165"
     CDS             26334..28553
                     /locus_tag="VXE25_001165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001856353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="HEV0771635.1"
                     /translation="MLKKYPCTMQHDQSDCAAAVVSTVLLSYKKELSIMKIREIIGTD
                     MYGTTVSGIVSGLNKLNFTVKAVRVALEDLTPKLTFPAILQVKNDLGQNHFVVLHSIK
                     RNSKFYVADPASGIRKMSSDELGEIYQGITLFMVPNSDFERGKLKGKGLLDLFGRLIF
                     NQKGLISTVILASFVLSIIGILSSLFSKVIMDEVIPYALKNSLYMFLIVFGIVSFLQT
                     LLSAFRQHVLLFLSRKIDIPVLMGYYDHIIHLPYSFFGSRRVGDVLTRFQDAMTIKNV
                     FTSVSISLVMDIILSVISAVVLWTINQSLFLILVFMVIVNIILIYCFKKPYKKINHEQ
                     MEANGLLNSQLIESIRNIDTIKSQHDEEQRLNKIEEKFVHTLEIGYKEGVLQNIQSTI
                     SSMTSTMGGLLFMGVGALFIIDGKMTIGDLLVFQTLSQYFTEPIQNLVGLQLTFQEVQ
                     VAVSRLQELMEVDREDIALDYSIRDFTLCDDIEFKDVTFAYGSRPPVIKDFNLRIKQG
                     EKIAFVGESGAGKSTLVRLLLRFINPSEGKIRIGENDLSDLDYGKLRKKISYIPQTIE
                     LFTGTIIDNLKIGNPSVTYEDMVRVCRIVGIHDTIQRLQNRYGSFVEEGGQNFSGGEK
                     QRLAIARALLSKADLYIFDEATSNLDSFSEQIIQDLIFNKIIDKTTIVVAHRLSTILR
                     CDKICFLENGTIVEYGTHEELMAKNGKYARMVGLQSVQVNQQIQSQAVLDIEEVTYG"
     gene            28546..29013
                     /locus_tag="VXE25_001166"
     CDS             28546..29013
                     /locus_tag="VXE25_001166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001096140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HEV0771636.1"
                     /translation="MAKLEVKDNKKLVLKSVICKKLHDTKVEDVDQEINKFHQHLQLL
                     KAQIFGPLIVKSCGTTIHDDGLITTDFEFYIQAHNAQQYSNIYDVQDSISVPYCLYVR
                     FEDSPEYLQYAYSKLDLYVYENDIQTDGIVYTVYVNSSPEKMVVDIFRPIVSL"
     gene            29010..30362
                     /locus_tag="VXE25_001167"
     CDS             29010..30362
                     /locus_tag="VXE25_001167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="HEV0771637.1"
                     /translation="MKLYNKSELRYSRIFFDKRPPAFAFILIISTAIILSGALVGAAY
                     IPKNYIVKANGNSVITGTEFLSAIGSGKVVTLHKSEGDMVNAGDVIISLSSGQEGLQA
                     SSLNKQLEKLRAKEAIFQKFEQSLNEKYNHLSNSGEEQEYYGKVEYYLSQLNSENYNN
                     GTQYSKIQDEYTKLNKITAERNQLDADLQALQNELLQLQQQGDSPSLSDTTSADDKAK
                     LETKISEITTKIEALKTNITSKNSEIDSQQSNIKDMNRTYNNPTSQAYNIYAQLISEL
                     GTARSNNNKSITELEANLGVATGQDKAHSILAPNEGTLHYLVPLKQGMSIQQGQTIAE
                     VSGKEKGYYVEAFVLASDISRVSKGAKADVAITGVNSQKYGTLKGQVRQIDSGTISQE
                     TKEGNISLYKVMIELETLTLKHGSETVVLQKDMPVEVRIVYDKETYLDWILEMLSFKQ
                     "
     gene            30510..30815
                     /locus_tag="VXE25_001168"
     CDS             30510..30815
                     /locus_tag="VXE25_001168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000420335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPAR17_0115 family bacteriocin-like peptide"
                     /protein_id="HEV0771638.1"
                     /translation="MELILPNNYVDLEQEEMMYLDGGEPMSISAIVALAITIGGASYS
                     TGYVLGERVYYSGYKNSDYQKNKWGIRGAMLAAFGAIGAVVMLGFENRYYALVTGRG"
     gene            31149..31502
                     /locus_tag="VXE25_001169"
     CDS             31149..31502
                     /locus_tag="VXE25_001169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="argininosuccinate lyase"
                     /protein_id="HEV0771639.1"
                     /translation="MELVLPNNYVALEQEEMMYLDGGAYLSKRACQGICAALAMSPGT
                     FIALAGAAVLTKKLINYIKVGGLGGWLIGAAAGVLAGAAGRIAYCIGYGALNRGCDIS
                     GNPYPWDGFISATVR"
BASE COUNT         9764 a         5426 c         6768 g         9626 t
ORIGIN      
        1 tataatctct ttataagatt tgcccatcag acgaaatata atggattgaa actagaatag
       61 tacacctcta cttctaaaac attgttagaa atcgatttga ctttcctgat cgatttgtcc
      121 tgttcttgtt tcattttact atagaacgat ttgaaggcgt ttatgatatt tagctgtacg
      181 agagtctttt aaaagtgttt tgatggtttg gatttcttct ttagttgatt tcatatcact
      241 gttatataat gctttttgat tttagtctag tattagtaag cagactcaaa ccttagaaaa
      301 tcttttgaga tcattgacag gtgtatcgaa tcctaccaca gattcagcac gtctggtttt
      361 ggcagaggct aagaaagctt ttgcagatga tagtttgaca gagcaaggtt tacgtgatat
      421 cttgcaaaca gtcaaagatg ccattgcttc cctagagtcc attaaggaaa gccagtcagc
      481 aactaaggat ggaggacaaa cagcgggcaa agaaacagca ggagaagatg agtctgcaaa
      541 tcaaactcaa gaaattagcc aaggaattaa gtaaacttct taaagactca aaccttgaaa
      601 cagtagataa ggatgtcctt gaaaactctc aaaaagaact tcaaaaagca gttttgttct
      661 tggcagatga aaaaggctct gagcatactg aagcagaggt gattgataat cttaaagagg
      721 ttattgctaa gttgaaagca aacgcctaat aacatattaa aaatctccag attaggaact
      781 atcgctgagt tccctagtct ggagattttt cagtataccc cgttgttgga tgcttataac
      841 agagtgacgc catcactggg ctaatagaga taaaataaac aattgattta ggacatttgt
      901 ttgatagtgg tgataaagtt ttaaatctgc tacataattt gtggagtttt ttctataatt
      961 aggagtttaa cctaacctgc aaataggagt atactaataa tgtaatcgtt atcaaaagtc
     1021 taaaaaagaa tttttagatg gatatcaaaa taaaaaggga ggaaattatg aaaaagtttt
     1081 caaaaacatt gagagacaac tggatctttc tcttgatggt tttgccaggg gcactctggt
     1141 tgattctatt cttttacatt ccagtatttg ggaacgtggt tgccttcaaa gactaccaca
     1201 tgaccagtaa tggtttcata gatagtatca taaatagtaa atgggtcgga ctcgataatt
     1261 tcagattctt atttagttca agagacgcct ttattatcac acgaaatacc gtcctctaca
     1321 atcttggctt tatctttcta ggtttagttg tatctgtagg gattgccatt atcctcagcg
     1381 agctccgttc taagagaatg gtgaagattt tccaaacttc tatgttgttc ccttacttct
     1441 tgtcttgggt tatcatcagt ttctttacag atgccttcct aaatattgat aaaggggtgt
     1501 tcaatcatct attggaaagt cttggtctca aagaagtcaa tttctacgct gacctgggca
     1561 tctggcccta tctcctactt ttcctaggta tttggaaagg ttttggatat agcagtgtca
     1621 tgtactatgc gacgatcatg ggaattgatc caacctacta cgaagcagcg acagtggacg
     1681 gagctagcaa gtggcaacgt attcgcaacg taaccattcc tcagttgact ccgcttgtaa
     1741 ctgtattgac catccttgca gtcggaaata tcttccgcgc agacttcggt ctcttctatc
     1801 aaatcccaca caatgctggt cagctttaca atgtaaccaa cgttttggac gtatatgttt
     1861 ttaatggttt gactcagaca gcagatatcg gtatggctgc agcagccggt ctttaccaat
     1921 ccgttgttgg tttgattctg gttatcctat caaacttgct tgcaagacga gtcgatccaa
     1981 actcagcttt gttctagaaa ggaggagaat atggcaaaaa agaaaattaa aaaagaaaaa
     2041 attgataatg tcggcattca ctccttcagt aagaaagcag atatcttctt cagtatcatt
     2101 tcgggtttga ttgccctctc ttgtatccta ccttttgtat tcgttatcat tatttcagtg
     2161 acagacgaga aaagcctcct ccaatacggc tatagcttct tcccatccca atttggctta
     2221 gacggttttg agtttttggc acagtttaag gataaaatcc tacaagccct cttcatctct
     2281 gtctttgtaa ccgtagttgg gacattgaca aatgtcttta tcacaacaac ctatgcctac
     2341 gctatttcac ggacaacctt taagtatcgc agattcttta ccatcttcgt tctgctcagt
     2401 atgttgttca acgctggttt ggtaccaggt tatatcatgg tgactcgtgt gcttcagctt
     2461 ggggatactg tttgggcctt gattgttcca atgcttctct caccatttaa catcatcttg
     2521 atgcgttcct tcttcaagaa gaccattcca gaagccattc tagaatcggc tcgtatcgat
     2581 ggtgccagtg aagcccggat tttcttccaa atctgtttgc cattgtcact accaggtatc
     2641 gcaaccatca cgctcttaac agctcttggt ttctggaatg actggttcaa cgcccttctt
     2701 tacatcaaga gtgacaactt gtatccattg caatatttgc tcatgcaaat ccaacaaaat
     2761 atggactaca ttgccaaagc ggtcggcttg actggtcaac tgggagttgc tctaccgaaa
     2821 gaaacaggtc gtatggccat ggttgtggtt gcaacccttc caatcgcgat tttgtatcca
     2881 tttttccaac gctactttgt aaaaggtttg actatcggtg gtgtgaaaga atagtgctta
     2941 ttgagaaata acatttctca gttcccaact tcccttgtgt gaagttaata ctcttcgaaa
     3001 atcaaattca aaccgtgtca acgtcgcctt gccgtagata tatgtaactg acttcgtcag
     3061 tcttatctac aacctcaaag cagtgctttg agcagcctgc ggctagtttt ctagtttgct
     3121 ctttgatttt cattgagtat aagatcatta cattgtttat aagtttaaaa ataaaaaaag
     3181 gagtttttat catgaaaaac tggaaaaaat atgcttttac atctgctagt gtagtcgctc
     3241 tggctgcagg tcttgctgct tgtggaaatt tgacaggtaa cagcaaaaaa gctgctgatt
     3301 caggtgacaa acctgttatc aaaatgtacc aaatcggtga caaaccagac aacttggatg
     3361 aattgttagc aaatgccaac aaaatcattg aagaaaaagt tggtgccaaa ttggatatcc
     3421 aataccttgg ctggggtgac tatggtaaga aaatgtcagt tatcacatca tctggtgaaa
     3481 actatgatat tgcctttgca gataactata ttgtaaatgc tcaaaaaggt gcttacgctg
     3541 acttgacaga attgtacaaa aaagaaggta aagaccttta caaagcactt gacccagctt
     3601 acatcaaggg taatactgta aatggtaaga tttacgctgt tccagttgca gccaacgttg
     3661 catcatctca aaactttgcc ttcaacggaa ctctccttgc taaatatggt atcgatattt
     3721 caggtgttac ttcttacgaa actcttgagc cagtcttgaa acaaattaaa gaaaaagctc
     3781 cagacgtagt accatttgct attggtaaag ttttcatccc atctgataac tttgactacc
     3841 cagtagcaaa cggtcttcca ttcgttatcg accttgaagg cgatactact aaagttgtaa
     3901 accgttacga agtgcctcgt ttcaaagaac acttgaagac tcttcacaaa ttctatgaag
     3961 ctggctacat tccaaaagac gtcgcaacaa gcgatacttc ctttgacctt caacaagata
     4021 cttggttcgt tcgtgaagaa acagtaggac cagctgacta cggtaacagc ttgctttcac
     4081 gtgttgccaa caaagatatc caaatcaaac caattactaa cttcatcaag aaaaaccaaa
     4141 caacacaagt tgctaacttt gtcatctcaa acaactctaa gaacaaagaa aaatcaatgg
     4201 aaatcttgaa cctcttgaat acgaatccag aactcttgaa cggtcttgtt tacggtccag
     4261 aaggcaagaa ctgggaaaaa attgaaggta aagaaaaccg tgttcgcgtt cttgatggct
     4321 acaaaggaaa cactcacatg ggtggatgga acactggtaa caactggatc ctttacatca
     4381 acgaaaacgt tacagaccaa caaatcgaaa attctaagaa agaattggca gaagctaaag
     4441 aatctccagc gcttggattt atcttcaata ctgacaatgt gaaatctgaa atctcagcta
     4501 ttgctaacac aatgcaacaa tttgatacag ctatcaacac tggtactgta gacccagata
     4561 aagctattcc agaattgatg gaaaaattga aatctgaagg tgcctacgaa aaagtattga
     4621 acgaaatgca aaaacaatac gatgaattct tgaaaaacaa aaaataatca gctaaattga
     4681 tttcgtgtat tcattcctaa ctcctaaaat aagaatcact gctttcctca ggttggtctg
     4741 gggagggcag tggttttttt ggcacaagga tatagatatc catgttttct cttgtcctta
     4801 ttttaaccat tcaggaaatt tcgagaaccc tctacaattt ccagtcaaat aaattgcatt
     4861 cgttttctca agcaggtata ctagtatgga taaataaaaa atttagaaaa tttaagaata
     4921 gaaaagagaa caaatcttat ggcaaaagat attcgtgtct tactttacta cctttatact
     4981 ccaattgaaa atgcagagca atttgctgca gaccacttgg ctttctgtaa atcaatcggc
     5041 cttaaaggcc gtatcctagt cgctgacgag ggaattaacg gaacagtttc aggtgactat
     5101 gaaacaactc aaaaatacat ggactacgtt cacagccttc caggaatgga agaactctgg
     5161 ttcaagattg acgaagaaag tgaacaagcc ttcaagaaga tgtttgttcg ctacaagaaa
     5221 gaaattgtcc accttggttt ggaagacaac gactttgaca atgacatcaa cccacttgaa
     5281 acaacaggtg cttacttgtc tccaaaagag ttcaaagaag cgcttcttga taaagatacc
     5341 gttgtccttg acacacgtaa tgattatgag tatgacctag gacatttccg tggggctatt
     5401 cgcccagata ttcgcaactt ccgtgagtta ccacaatggg tccgtgataa caaggaaaaa
     5461 ttcatggaca agcgtgtcgt ggtttactgt acaggtggcg ttcgctgtga gaaattctca
     5521 ggctggatgg tccgtgaagg ctacaaagat gtcggccaat tgcacggagg aatcgcaact
     5581 tacggtaaag acccagaagt tcaaggtgag ctttgggatg gaaaaatgta cgtatttgac
     5641 gagcgtatcg ccgttgatgt caaccatgtc aacccaacca tcgtagggaa agactggttt
     5701 gatggaacac catgtgaacg ttatgtcaac tgtggaaatc ccttctgtaa ccgtcgtatc
     5761 ttgacatcag aagaaaatga agacaagtac cttcgtggat gctcacacga gtgccgtgtt
     5821 cacccacgta accgctatgt ttcaaaaaat gaattgacac aagctgaagt gattgagcgc
     5881 ctagccgcta tcggtgaaag cttggatcaa gcagctactg tataagatca aacagtcctc
     5941 aggggctgtt tttctatgct ttgtactcaa aaatctaaag tttgtttctg tatctttcag
     6001 aaaaataagg tatactgtat gtaaacgatt tcaaaggagt ccagttatgg caaaaacatt
     6061 ttttattcca aataaacaga gcattttagg agaacaagag attttgaatg ccaagtcgat
     6121 cttggccttg ctagacggtt tggagtcaca tagctatgat gtagtctatc tccgtcagcc
     6181 tcttaatcgt ctcgaatata tcgagtgtgc gatagtgggg caatcacaat ttctctttaa
     6241 ggtcagttat gctgatggtc aaaaggctta ccgtgtcgat cttcctgacc tactaacaaa
     6301 gacagactgg cagattatca agtcattttt agatgctttg cttgcttata cagggactga
     6361 tattgaaggg ctagatggtt ttgattttga agcttatttc caagcaagta ttcaagccta
     6421 tctagcagac cctgtagctc gttttacgat ttgccaagga atttttaatc ctattttctt
     6481 tagtcgtgag aacttgaaaa gctttttaga ggcagatggc ttggctcagt ttgaagcgcg
     6541 tgtgcgtgcg gttcaagaga cagatgccta ctttgcgaga gtttccttct atcaggatgg
     6601 agaaggaaaa gtgcatggcg tttaccatct agctcaagga gtcaagacag ttttaccgag
     6661 agaaccgttt gttcctgcag cctatattga gcaattggtg gataaggaag tgcagtggga
     6721 gattgacttg gttcaaatca caggagatgg ctctaaacca gaagactatg aagccattgc
     6781 ccgcttggac tatgcaaaat tcttagaggt attaccccta tctttttacc accaactaga
     6841 cgccaatcaa atagaagtgc aacccatatt agacaaagat tttaaagcat tagcacaaga
     6901 agagtaaagc agaagcaggt caatcgactt gcttttttga catagaaaaa atcctgccaa
     6961 ggatgacagg attgctactc aatgaaaatc aaagagcaaa ctaggaagct agccgcaggc
     7021 tgtacttgag tacggtaagg cgaagctgac gtggtttgaa tttgattttc gaagagtatg
     7081 aagtttaaag aaaggccaag atacgaagat aatctccaat cagtgccact tcagctacaa
     7141 agaagaggag gataataact ccgttcacaa ggacagacaa gaataattga tagaaggagt
     7201 cggtttcact tgcttgactt ggtcttgtaa tgatatggag actggcaagc agaatgattc
     7261 caatgctaat cacacacaag agagctgtaa atcgtaggct atcaaagaaa gcaaagaaac
     7321 tagcaatagc agtgaggaag attggaattg ccaagagttg actatattgt tggagaacct
     7381 tgtctagcgt ccagtccttt tcctggtgga taaatcgtct cacaacgaaa ctacccaaga
     7441 ggaatgaaaa gaagaagagt gttgtcgcta ctaggataga gacgatagaa aaaagagtta
     7501 aaggagctag ctgctcaggg aagcgactgt taatgcttgc tatatgtcca tagtaagcat
     7561 gtttgatgtg atagatacta aagaaaaagg aagatgcaga aaacagaatg agcaagagaa
     7621 aggctgtgta actgtgtgtg atacttgttt ccaacttact tgtaggagat ttgatcgctt
     7681 ccactagcca agaccaaaaa tcaagcactt gctctttcca tttatcccta gattttggag
     7741 cttggtcggg gatataagga ctttctaaag atttactgat aagaagtggc tctttcgtgg
     7801 ttgctttttg ctgaggaaga gcttcttggc tctcttcagc tatagtgact ttttctgttt
     7861 ctttagaaag gtctgactct tcttcagtag aattagatgc cttcttttct tctatttctg
     7921 ttctcgcttc accgacttca ggagtttcaa ttttctcttc ttgctggctt tccagttcga
     7981 cttcagcttg agagacttcc tcctctactt gagtattttt tccaattggt gtatcgaaat
     8041 cggctatcgt ttcttcagcc ttgtctgcaa cctcttgagc ttgctcttca ggcttgttct
     8101 tgcttgttgt ttttacaaaa tcattacttt caaaccattc ttgtttcatg gtagaacctc
     8161 cttttggtta gataaatatg cttccatagt agcagatgta agcgtttttg tcaacgtctg
     8221 cttggtgtgg atattagatc aatattatca tcagatctcg caatgagttg atccttgaca
     8281 tcggtttttt cagttttgta agggttgctt aattccgtac ctcttgattc aggcttttct
     8341 cttgtgaatt ggaagataga accgtagtta cttgagatgt cccagttaat tcgttggctt
     8401 tctttctggt ctaggatgat tctgagataa tctttggcag tcagttcaac cttaccatgg
     8461 acttggatat tttcagcgtg gaagtgatta tctgttgact ctagctgact atctgtaaga
     8521 actgtatcaa agatattaac gatattgggc gttgtgagtt tactgttttt gatacgactt
     8581 ccttcaattc ggaggatata gctgtttgta ttgagggtcg cattttcaag gctagcattt
     8641 atgatggtgg tttgtccgcg attggctgag atgttgatcc cttttagagt tctccctttt
     8701 ggtagtcgga gaataacttc ttcaaaacga ctagagtagc tacttgcgat atgaagaatc
     8761 ccaccaattc cagaagagag aaacggagtt tcagacagtt tcttatcagt gagactcaga
     8821 gttctatcgt tctgattggt gataaaatca tggtgagcag aaagagatgg atggtaagaa
     8881 atgtggattt gatcatcgaa agagtctgtg atggtgagcg tgtgttggtg gagagtaatt
     8941 tctaggtttt cgacttcctt gccaaaggtt agcttttccg tacggctatc atagacaggt
     9001 tctttggaca tggaaagtag gctcttaatc ccgtcagatt ggatacctac aaaaagcagg
     9061 ataaagccga taacggtagt caccacacca aagatgagaa atccttttgt ccatttacgc
     9121 atgctgatta cctctctttc cttttttaag aacaaattgt accagacgaa caatgagtag
     9181 accgaagaag cgagctacat aggaaatgcc aagtaaaact agcgaagaag caccgatagc
     9241 cagtaaacca gaaccaaaaa tcaagataaa ggctgatttg gcttgggcga ggatagtgaa
     9301 actttcaact aaaaatagga atccgccgat gatacccagt atggaaactg caaagaaagc
     9361 cagaatgaca gtcaaagcgg ctacaaggat tgcgaacagg gtcacgagga tggcgattcc
     9421 cagaggaatg ccgataggtg ctgcaaggag ggctaacaag gcgatatgta aaatttgtcg
     9481 gttatttttt tgagcgggtg cttcattgat ttttttatcg agaagattgg atagaacttc
     9541 gtgggccgct tctttgggag ttcccaaact agcgatgagt tcttcttctc cttcgactcc
     9601 agcatcgtca aagagctctc tgaaatagtc catggcttcg atacggtcag cttcaggtag
     9661 tttcttgaga tagagttcta gctgagtcag gtattcagtt cttgtcatgg cggatactcc
     9721 cttctatgat gccattgatg gtgtctgtat agagtgtcca ttcatctttt agggtcaaga
     9781 gctgctctat accaccgttt gtcaaggagt agtatttgcg catgcgacct tggaactctc
     9841 tagaataggt tgtcagaaag ctattgcctt ccaatttttt gagaatggga tagagtgtgg
     9901 attctttgat attagcgatc agcttaatgg tttggctaat ctcataacca taagaatcac
     9961 cctgctccag tacagccaag atgagaaatt caatcaaggc agaggatgtt ggaaagtaca
    10021 tgggaaacct ccttttctaa tgtgtaagat ttttatatat aatttttcta cacatacatt
    10081 gtacatctaa aagaaagccc tgtcaagaga aatgtgtaaa atttttatat ataaaaaact
    10141 tctagctaaa actagaagtt taaaggatct tatccgctct gtccactgta aagagggcca
    10201 cagtcatcag gatatagatg agcaagaggg cagctacagc tggtacccaa gagtggaaca
    10261 ggtcaaaact gtaaccaaag agggttggcc caaaggctgc taggatatag cctcctgttt
    10321 gagataggcc ggacaattgg gctgtctttt caggggcgct tgtcttgagt gaaaagttga
    10381 ccatgagata agggaagagg gcgctggttg cggttccgat gaggagatgg atggtaagcc
    10441 agtaaatgaa attattgatt gggaaaaaga gcatggaaat gccgaccaca ccagctagtg
    10501 aaaccagagt gagcatgagc tgacggttgc gagtagataa actggttgtc aggcttggga
    10561 tggtcattga aaaaggaatg ctaatcagag ataagataga agtcagcaag ccagcttcgt
    10621 gactggatag acctgcatgg atagacatgg taggtaacca ggtcatgacg gtgtaaaaga
    10681 tcaaggattg aaaacctgaa aagataataa ttgcccaaac ctgtttatta cgcatgacct
    10741 ttatttgact tttttgtttg gtttgtggag ctagtctatg attatagcgg tgatttggga
    10801 gccagaccaa aaaagttgct agacagagta acgtgaggag gaggataagt cctttccaag
    10861 aactggcttg tgtaatgggc acagctagat aggaagccag agccgttgca atccccatag
    10921 acgttacata taaggtggtc agaaaaccaa ttttctttgg ttgattggct tggataagac
    10981 taggaagcag gacattgatg actgcgacac ttgccccaac catcaaggtt cctagataga
    11041 gcaggggcag attgattagt cgaatgagtg agccgatggt caagaagaag aggctgtagg
    11101 tgaagagatg ctccaagccg attttctgag ccagtcgggt agaaaatggt gaaaagaggg
    11161 taaacataag gagaggcagg ctggtcaaga caccaagcga actaacttct acctccagac
    11221 cttgcgaaat atttcccaaa ataatgggta aaacagtaaa aggagttcgc aaggaaacac
    11281 caatcaggat aatacctgga acaaaaaaga gtgattgctt tttcatataa tacctcttct
    11341 agctgatttt aataacagct tattttaagg ctttttcact ataatgtcaa gtaaggtttc
    11401 tggctttcaa gataaaaatg ggaaagtctt gaaaattatg atagaatggt ggaaggaaaa
    11461 attcaggaga gtagtagtga ctcaaaatgt tgaaagtctt ctcgtatcca ttgtaatcag
    11521 tgcatacaat gaagaaaaat atctgcctgg tctaattgaa gacttaaaaa atcaaactta
    11581 tcctaaagag aatattgaaa ttctatttat aaatgctatg tccacagatg ggaccacagc
    11641 tatcattcag caatttataa aggaagatac agagtttaac tcaattagat tgtataacaa
    11701 tcctaagaaa aatcaagcta gtggttttaa cctgggagtt aaacattctg taggggacct
    11761 tattttaaaa attgatgctc attcaaaagt tactgagagt tttgtaatga acaatgtggc
    11821 tattattcaa caaggtgaat ttgtctgtgg ggggcctaga ccgacgatta tcgaaggaaa
    11881 aggaaaatgg gcagagacct tgcatcttgt tgaggaaaat atgtttggca gtagcattgc
    11941 caattatcga aatagttctg aggatagata tgtttcttct atttttcatg gaatgtataa
    12001 acgagaggtt ttccagaagg ttggtttagt aaatgagcaa cttggccgaa ctgaagataa
    12061 tgatattcat tatagaattc gagaatatgg ttataaaatc cgctatagcc caagtattct
    12121 atcttatcag tatattcgac caacattcaa gaaaatgctg catcaaaagt atttaaatgg
    12181 tttgtggatt ggcttgacaa gtcatgttca gtttaagtgt ttatcattat ttcactatgt
    12241 tccttgttta tttgttttga gtcttgtgtt tagtctagca ttgttaccga tcacattcgt
    12301 attcataact ttactattag gtgcctattt tctacttttg tcactactca ctttgctgac
    12361 tttattaaaa cataaaaatg gatttctaat tgtgatgccc tttcttttat tttccattca
    12421 ctttgcttat ggctttggga cgattgtagg tttaattaga ggatttaaat ggaagaagga
    12481 gtacaagaga acaataattt atttggataa aataagccaa ataaataaaa atatgctata
    12541 ataacaatat agtaaaactc ttttaaggag gagtagattt ctatgaataa aaaactaaca
    12601 gattatgtga ttgatctggt ggaaatttta aataaacaac aaaagcaggt tttctgggga
    12661 atatttgata ttttcagtat ggtggtttcc atcattgtat cttatatttt attttatggg
    12721 ctgattaatc cagcacctgt tgactacatt atctatacga gtttggcctt cctgttctat
    12781 caattgatga ttggtttttg ggggttgaac gcgagcatta gtcgttacag caagattacg
    12841 gatttcatga aaatcttttt tggtgtgact gctagcagtg tcttgtcata tagtatctgt
    12901 tatgccttct tgccactctt ctccatccgt ttcatcattc tctttatctt gttgagtacc
    12961 ttcttgattt tattgccacg gattacttgg cagttaatct actccagacg caaaaaaggt
    13021 agtggtgatg gagaacaccg tcggaccttc ttgattggtg ccggtgatgg tggggctctt
    13081 tttatggata gttaccaaca tccaaccagt gaattagaac tggtcggtat tttggataag
    13141 gattctaaga aaaagggtca aaaacttggt ggtattcctg ttttgggctc ttatgacaat
    13201 ctgcctgaat tagccaaacg ccatcaaatc gagcgtgtca tcgttgcgat tccgtcgctg
    13261 gatccgtcag aatatgagcg tatcttgcag atgtgtaata agctgggtgt caaatgttac
    13321 aagatgccta aggttgaaac tgttgttcag ggccttcacc aagcaggtac tggcttccaa
    13381 aaaattgata ttacggacct tttgggtcgt caggaaatcc gtcttgacga atcgcgtctg
    13441 ggtgcagaac tgacaggtaa gaccatctta gtcacaggag ctggaggttc aatcggttct
    13501 gaaatctgtc gtcaagttag tcgcttcaat cctgaacgca ttgtcttgct cggtcatggg
    13561 gaaaactcaa tctaccttgt ttatcatgaa ttgattcgta agttccaaga gattgattat
    13621 gtacctgtga ttgcggacat tcaagactat gatcgtttgt tgcaagtctt tgagcagtac
    13681 aaacctgcta ttgtttatca tgcggcagcc cacaagcatg ttcctatgat ggagcgcaat
    13741 ccaaaagaag ccttcaaaaa caatatccgt ggaacttaca atgttgctaa ggctgttgat
    13801 gaagctaaag tgtctaagat ggttatgatt tcgacagata aggcagtcaa tccaccaaat
    13861 gttatgggag caaccaagcg cgtggcggag ttgattgtta ctggctttaa ccaacgtagc
    13921 caatcaacct actgtgcagt tcgttttggg aatgttcttg gtagccgtgg tagtgtcatt
    13981 ccagtctttg aacgtcagat tgctgaaggt gggcctgtaa cggtgacaga cttccgcatg
    14041 acccgttact ttatgaccat tccagaagct agccgtctgg ttatccatgc tggtgcttat
    14101 gccaaagatg gggaagtctt tatccttgat atgggcaaac cagtcaagat ttatgacttg
    14161 gccaagaaga tggtgcttct aagtggccac actgaaagtg aaattccaat cgttgaagtt
    14221 ggaatccgcc caggtgaaaa actctacgaa gaactcttgg tatcaaccga actcgttgat
    14281 aatcaagtta tggataagat tttcgttggt aaggttaatg tcatgccttt agaatccatc
    14341 aatcaaaaga ttggagagtt ccgcactctc agtggagatg agttgaagca agctattatc
    14401 gcctttgcta atcaaacaac ccacattgaa taaaaaagaa aaacgcatag tatcaagtta
    14461 cacaaccttg gtaatatgcg ttttattatg tagagactta tactcttcga aaatctcttc
    14521 aaaccacgtc aacgtcgcct tgccgtatgt atatgttact gacttcgtca gttctatcca
    14581 caacctcaaa acagtgtttt gagctgactt cgtcagttcc atctacaact ttaaaacagt
    14641 gttttgagca gcccgcagct agtttcctag tttgctcttt gattttcatt gagtattact
    14701 tcattttctt ctgaaataga gttgtcgccc agtctatgct attgaaaata cgccaaaact
    14761 tctaagggtt tgtgagcgat ataatcaggt tgatagttta gtagatctgc ttgctctcca
    14821 aatccccaag tgacggccaa tttctgaata cctgtttctc gagctcccag catatcaaac
    14881 ttggtatctc cgatgatgat ggcttgttct ggtgctagtt gatgtgtctg taaggcttgg
    14941 tgaatgacat ctgccttatg gggtgcttca gggctagaac cataaatacc atcaaagaaa
    15001 tgatggattt ccaagttttt ggccatgtct tgagcagtag atgtattctt tgtcgtggtg
    15061 atgtagagtg gataactgct cgataactcc tcaagcaagt ctataatctg aggaaagagt
    15121 tgagcttcat agatgccttt tgccttatag taagaacgat atatctgcat ggcttcagaa
    15181 atttggtctt tggacaggca ggtcgcaaaa ctactttcga gaggtggtcc cataaaacca
    15241 cgaatagttt tggcatcagg gctaggcacc cccagctctt taaaggtata ggtaaaggca
    15301 ttgtgaatcc cgatagaact atcaacgagg gttccatcca aatcgaaaaa aatcgctgtg
    15361 atagaggtca tggtttctcc tatttgataa gcttattctc cgaaaatctc tttttggagg
    15421 cgacgaccag taggggtggt agcgagtcca ccttcagctg tttcacgaaa ggcagttggc
    15481 atgcttgctc ctacttggta catggcatcg atcacttcat ccacagggat tttagattcg
    15541 atacctgcca aggccatgtc tgctgcgatg aaagcaaagc tagctcccat ggcattacgt
    15601 ttgacacagg gaacttcgac caaacctgca acagggtcac agatgaggcc tagcatattt
    15661 ttaatgacaa aggcaatagc ttgactggcc tgataaggtg ttccacctgc agccagagtc
    15721 aaggcggcag cactcatagc agaggctgaa ccaacttcag cttgacatcc accctcagca
    15781 cctgagatgg aggcattgtt tgcgatgact agtccaaagg caccagcagc aaagaggaaa
    15841 tccaattgtt gctcgtggct gaggtctaat ttttcaatag cagcagtgag aacggaaggg
    15901 agacaaccgg cacttcctgc ggtaggagta gcgcagacca agcccatttt agcattgtgt
    15961 tcattgactg cgatagcatt tcgggcagca gagagaatcg tgtaatctga taaagttttt
    16021 tcgtttttga tgtagtgatc caatttggca gcatctccac ctgtcaggcc actacgagat
    16081 ttattttcat tgaggccaag ttggacagag gctttcataa cttccagatt gcgttccatg
    16141 agaaggaaga cttcttcacg ttcgcgaccg gtcaattcaa actctgttgt aatcatgagt
    16201 tctgcgacat ttccttgaaa gtccagatct gcttgctcga ccaattcttt gatagaataa
    16261 aacatgcttc ctcctattta aagaaattga cattgtggag atgagggatt tttcgaattt
    16321 cttcgatagc ctcatcacag ttgcgactgt caacttcgat aatcataatg gctttttcac
    16381 cagctttttc acgagtgaca ttcatctggg cgatattgat accatagcgg gaaagcgcct
    16441 ctgtaacaag ggcaatcata cctggaatat cttgatgaac gatgatgata gtcggtgtat
    16501 tcatattgag agagacggca aaaccattga gttcggttac ctgaatattt cctccaccga
    16561 tagaaatacc agtcacgctg atggtcttgt gggcattttt aacagtaatt ttagtggtgt
    16621 tagggtgagg ggcattgctg tctttctgaa tggtccagac aatcttgata ccacgcttgt
    16681 gggcaatttc cagactattt ggaatttcag gatcatctgt atccattcct aaaatacctg
    16741 caacaagggc taggtctgtt ccgtgaccac gataggtctt ggcaaatgag ttaaaaagtt
    16801 ggaattcaac ttctgtcgga gtatcatcaa aaatggaaga gacaatcttc ccaatacgaa
    16861 cagcaccagc ggtatggcta ctagatgggc caatcataac tggtccgatg atatcaaaga
    16921 cagattgaaa acgaagtgat ttcatcagtt tccccttata aaaattctta tctctattat
    16981 atcaaagaat gaggggcttg gctttaattg tggatgaaaa cctttctaat acctcaaata
    17041 gcataaaaat agtatctttt atgacaaaaa acaccttatt tagggaaata aaaaataatt
    17101 ttgtaatatt tctacataaa agtgtcaaga aacggtaata tttaaagggt atgatagaac
    17161 tatagaaaga aggagaattt tcgaatatga aatcaataac taaaaagatt aaagcaactc
    17221 ttgcaggagt agctgccttg tttgcagtat ttgctccatc atttgtatct gctcaagaat
    17281 catcaactta cactgttaaa gaaggtgata cactttcaga aatcgctgaa actcacaaca
    17341 caacagttga aaaattggca gaaaacaacc acattgataa cattcatttg atttatgttg
    17401 atcaagagtt ggttatcgat ggccctgtag cgcctgttgc aacaccagcg ccagctactt
    17461 atgcggcacc agccgctcaa gatgaaactg tttcagctcc agtagtaagt gaaacagttg
    17521 tttcaactgt aagcggatct gaagcagaag ccaaagaatg gatcgctcaa aaagaatcag
    17581 gtggtagcta tacagctaca aatggacgtt atatcggacg ttaccaatta acagattcat
    17641 acctgaacgg tgactactca gctgaaaacc aagaacgtgt agcagatgcc tacgttgcag
    17701 gacgttacgg ttcatggact gctgctaaaa acttctggct taacaatggc tggtattaag
    17761 aactaacgaa caaataatat gtaaaaggtc gaggagctcc ctcgactttt tttataattt
    17821 ctttggttga taatgggtct ctacttcttt tttgagatga gacagcatag aagtttcctc
    17881 ggtcagctcc agaagtgaga aacctttttg gataagttta gcattatctg tacaaatccc
    17941 aatacggaca tagcagatag caagcctatc gtagcttttc ttattcttgg cgtcctccag
    18001 taaagtgtag cagatttgct tacacatgtt tttatcttga ttgtatagat agagtgtgga
    18061 aaggtttagc aggattgcta ttcgcaagtc atataaatgt tgatagtttt tatagacttc
    18121 taagcgttgc aagattttct cggattattg acaaataaac ggacattctg atagacgatt
    18181 gccctagcgg cttagtgtaa actttacaaa tttggcttgt aattttttta taaaattcac
    18241 ttcagttact tgacagttat tatattttcg cttattatat agataaaagg atgggatagg
    18301 attttaaaaa tttgaaagcg ctatccatat tgtttattgg actgattctt gagtaatagt
    18361 tagagtgtgc ttaatactac tctggttgtt caaggacctg atacagaagc gcaccattct
    18421 cccggttaag agtaagttcg ttgttaaaaa atgaaatgag atagaaggaa ggtgagtcca
    18481 atggactacg atacttgttg ataaattact atagctgttt ttacggaaca gctctcgata
    18541 ataggagaaa taaatcatga gaaaattagt taaaattggt gttgcatctt taatggtatg
    18601 tggtatactt gctactacaa atgctttagc agtatgggtt gagggtggtc aatggaacta
    18661 tggagtaggt tggacaggaa cttttggata ttctgattac ttacattcta ctcgatatca
    18721 tacagcaact gttagacatg ggggtagaac ctctaaggat tatgcaaaac ctgaggcatg
    18781 ggctagagct tccctcacca agattccgcc aacaggaatg gaatatttct atggatttga
    18841 gtaaaattct tccctctcct atttggagag ggaaaactgt agtggaggca cttttatgaa
    18901 aaaaatcagt aatttctgta tgttactcct gcttctgtgt accacttttt ttgtttttaa
    18961 tgtaaactat acacgagaag tggttcggat tcaagaaatg ggaaagactg tagattcttt
    19021 ggatttgtat ttgaaagata ttaacgaacc tgcagcgtct gttcttcgat tttttgagga
    19081 tgtatcaaag gagtataaag tctccatcat caaaacagac agtggtgatg aggtggtcaa
    19141 gtctggtgtt tttgataaag ataccttccc ctaccaagag tttgggattt cttctcttga
    19201 ttttaccaca gatggtgaag gagtctatag taataaagaa atttccaata aacttggtac
    19261 gattccgacc tttctaaaag ccaaacctat tcagcttatg acttttcaaa cctatatcaa
    19321 ggatacatct cgtagtttaa atggtcgcta tacgataact tctacacaag agatggacaa
    19381 ggataggatt gtacagaaat ggagcgattt tttcaagata gaccaggcta ccttgctaga
    19441 gccgacctac aaaagtgcag tggaagtcat aaatcgagat ttgcttttat ctgccattgt
    19501 ttttgtcttg gctattttgc ttcttgtgtt agtgacagtg tatcaaccga tgatggagat
    19561 gaaaagagtt ggggtacaaa aattacttgg ttttcaagat agggctgttt tagctgatgt
    19621 tgtaaaaggc aacctttacc tcctcctagg tggggctctt gtgatcaatc taggcgtgtt
    19681 tttcttgctt gattataagc caaaagattt gtttcctatg ctgtggttgt ctcatttttt
    19741 gctgttgcag ctttatctct ttatcagttg gttgacttac ctcttaatcc aaaaaatgac
    19801 aatcagctct ctgctgaaag gtttttcatc tttcaaattt ggtcttatct tcaattatgt
    19861 gatgaaaata gggacaacta ttttactgac ggccttactg attggggtgg gcagaagttt
    19921 agaacaagaa aacaaagaac ttgcttatca gcaacagtgg gtaagtcaag gtaattacct
    19981 gaccttagaa accttcaaac tcaatgataa tctgtggcaa gaagagctag cagggtcagg
    20041 gaaatctaca gattatttct atcgatttta tcaggatttg gtagaaaaaa cgcaggcggg
    20101 ctatgtgcag agtagcagtc ttcctgtaaa aaattttgtc caatcagaac agattcagca
    20161 atatcagtta acagatacgg tggatgttta ctatgccaat cgcaattttc taaagagcaa
    20221 gggattcaag ctaccagata ccggtattaa aaaagttatt ttgatgccag caagtacgaa
    20281 aggtgaagaa gataaaaatc agctcttggg gaagttaatt gcctttcatt cgatgaagta
    20341 tgaagagcag caaaaacgaa cgatagagga gatggatgtc gagattgcct attatgaagg
    20401 agattggtca tttttcccat atagtgataa gcgaaaggaa aatctctcca atccaattat
    20461 tagcttggtc aatgattctg atatgatgtg ggatgagaaa gcctccctgt caacaactgg
    20521 cttaaataat ccgattaaaa ttgaaaatac ggttcaacat caaaaagaga ttacagagtt
    20581 agttgagaaa ttgtcagatg gaaattattt aaaattttca tctattcaag ccattcaaca
    20641 agagaaagtg gattcttatc gagatgctgt tcggaatttt aacctactct ttgctttgtt
    20701 tggtctcctt agcatgatga tttcctactt cttactagta acaactttct tattgaagcg
    20761 cagggatatc attaccaaga agtttatggg gtggaaactg gtcgatcgct accgtcctct
    20821 cctcgttctg ctcttgctgg gctatagttt ccctcttcta gtcttgattt tctttgccca
    20881 tgcgttctta ccacttctac tgtttgcagg ttttacatgt ctggatatac tatttgtgct
    20941 aggcttagct tctaggatgg agaaaagaag tctagtagag ttattgaaag ggggcatctt
    21001 atgattgagt tgaaaaatat taccaaaacc attgggggaa aagtgatttt ggataactta
    21061 tctctcagga ttgatcaggg ggatttggta gctattgttg gtaagagtgg tagtgggaag
    21121 tcgaccttgt taaatttatt gggtttgata gatggtgatt atagcggacg gtatgagatt
    21181 tttggtcaga caaatctagc ggttaattct gctaagtcgc aaacaataat ccgtgaacat
    21241 atctcttatc tgtttcaaaa ttttgccctg attgatgatg aaacggtcga gtacaatctc
    21301 atgctggcgc tgaaatatgt gaaattgcct aagaaagaca agctcaaaaa ggtggaagag
    21361 attttagaga gagtaggttt gtcagctact ttgcatcaaa gggtctccga gttgtctggg
    21421 ggcgaacaac aacgaattgc agttgctaga gccatcttaa aacccagcca gctgatttta
    21481 gccgatgaac ctacaggttc gctggatcct gaaaatagag atttggtctt gaagtttctc
    21541 ttagagatga atcgagaggg gaaaacagtc attatcgtga cccacgatgc ttatgtagcc
    21601 caacaatgtc atcgaatcat tgaattaggc gagggaaaat gagttcgttc agcttcattt
    21661 gaccgactga atactcatat ttttcagaga gaaatagcat aaataggcct aggaatgata
    21721 tttttatgtc attttcctgg gtttttctgt tttaaattga aaaaaaatac aatttaggct
    21781 tgacaaagga tgagtatagg agtattattt atacaataaa aaagaataaa cataaaggag
    21841 gctttgttat gaataagatg aagaaggtgt tgatgacgat gtttggttta gtgatgctcc
    21901 ccctactatt tgcttgtagt aacaatcaat cggctggaat tgaagccatc aagtccaaag
    21961 gaaaattggt tgtagccctc aatccagatt ttgctccatt tgaatatcaa aaagtggttg
    22021 atgggaaaaa tcagattgtg ggttcagata tcgaattagc caaggctatc gcaacagaac
    22081 taggtgtcga attggaacta tctcctatga gttttgacaa tgtactggct agcgttcaat
    22141 caggaaaagc tgaccttgcc atatcaggtg tttctaagac agatgaacgg agcaaggtgt
    22201 ttgatttttc aactccctac tatactgcaa aaaataaact cattgtcaaa aaatctgatt
    22261 tagccactta tcagtctgtc aacgatttgg cgcagaaaaa ggtcggagcg cagaaaggtt
    22321 cgattcaaga gacgatggcg aaagatttgc tacaaaattc ttccctcgta tctctgccta
    22381 aaaatgggaa tttaatcaca gatttaaaat cagggcaagt ggatgccgtt atttttgaag
    22441 aacccgttgc caagggattt gtggaaaata atcctgattt agcaatcgca gacctcaatt
    22501 ttgaaaaaga gcaagatgat tcctatgcgg tagccatgaa aaaagatagc aaggaattga
    22561 aagaggcagt cgataaaacc attcaaaagt tgaaggagtc tggggaatta gacaaactca
    22621 ttgaggatgc ctttaaagcg tccattgaaa aatagaaaga aggaaaagaa catgagtaaa
    22681 gaaaaagtaa ttttggccta ttctggcggt ttagacacat cagttgctat tacctggctg
    22741 aagaaagact atgatgttgt tgcagtttgt atggatgtgg gtgaagggaa agacttagat
    22801 ttcatccatg ataaggctct taaggttggg gcagtcgaat cttatgtcat tgatgttaag
    22861 gacgaatttg ctacagatta tgtgctagta gctctccagt cacatgccta ctatgaacaa
    22921 aagtacccct tggtatctgc cttgagccgc cctcttattt ctaaaaaatt ggttgaaata
    22981 gcgcatcaga caggagcgac tacaattgct catggttgta caggtaaggg gaatgaccaa
    23041 gtacgttttg aagtatcgat tgcagccttg gatctcaatt taaaagtgat tgctccagtt
    23101 cgtgaatgga aatggtctcg ggaggaagaa atttattatg ccaaggaaaa tggggtgcct
    23161 gttcctgctg accttgacaa tccctactct gtcgaccaaa atctttgggg acgtgccaat
    23221 gagtgtggta ttttggaaaa tccatggaat caggctccag aagaagcctt tggcatcaca
    23281 acttctccag agcaagctcc agatatgcca gaatacattg agattgagtt tagtgaaggt
    23341 gttccagttt ccctcaatgg agaagtgtta aaattggcag atttgattca aaaactcaat
    23401 gaaatagctg gaaaacatgg ggttggacgg attgaccacg tggaaaatcg cttggttggg
    23461 attaaatcaa gagaaatcta tgagtgtcca ggtgcagtga ccctgctgac agctcataag
    23521 gaaattgagg acttgacgct tgtgagagaa gtggctcatt ttaaaccaat catagaaaat
    23581 gaattatcaa atctcattta taatgctttg tggtttagtt cggctacaca agccttgatt
    23641 gcttatatta aagagactca aaaagttgtc aatgggactg caaaagtcaa actgtataag
    23701 gggagcgctc aggtcgtggc tcggaaatca ccaaattctc tttacgatga aaatttggcg
    23761 acgtatacta gtgcagatac cgttgaccaa gatgcggctg ttggctttat taagttatgg
    23821 ggacttccaa ccaaggttca ttctgaggtt caaaaaagcg ccaaatagga cgattggata
    23881 gagaggtgga tgtgatatgg ctaagaatac aaaattatgg ggtggtcgct ttggcaggaa
    23941 cgactttccc cattgatcgc caattgtcta gcgatttgct ggagtttaag caaccttata
    24001 caaattcttt ggatgctgtt agtgaccgcg attttatctt agaatttcta tcaaatgcca
    24061 gcatactcat gatgcatatg agtcgttttt gcgaagaaat gatcaattgg tgtagttttg
    24121 agtaccaatt cattaccttg tcagatacgt ttacaacagg ttcctctatt atgccccaaa
    24181 agaaaaatcc agatatggct gagttgattc gaggaaagac tggcagagtt tatgggcatt
    24241 tgtttggact gttgacagtc atgaagtcct tgcctttagc ttataataag gatttgcaag
    24301 aagataagga aggaatgttt gatacggtcg aaacgatttt aaattccctc gatgtgttgg
    24361 caggtatgtt atctagtttg caggtaaaca aggaaaaaat gcaagaatca acagagaagg
    24421 acttttcaaa tgcaactgag ttggcagatt atttggcagg gaaaggcttg ccatttagag
    24481 aagctcatga ggttgtggga agattagtgc tagactctat caagtctgct aaaaatcttc
    24541 aagattggac tttggaggaa ttacaaacct atcattctct cattaccgag gatatctatg
    24601 tctacttgca acctaaaact gctgttcaaa gacgaaattc cttgggaggc acagggtttg
    24661 accaagtcga ataccagatt gcagtcgcta agaaagcgaa tgaagctaaa aagtgatgga
    24721 gtgatgggtt cagaataaga ggttggtcga ttggcagcct ctttcttgtc gttgaaaaag
    24781 tgagatatat tgacttttga aaaaaatgtc ataattgagt tgggataaac gtaaaagtca
    24841 tactttctcg ttaaatcgtt cggcgattca tggtgacatg gacacatagt agtaaacaca
    24901 ctatgtggct tggcagagct aaaaacttct ggcttaacaa tggctggtat taagaactaa
    24961 cgaacaaata atatgtaaag agtcgaggaa atccctcggc ttttttatct ttccttcgct
    25021 tggtaataga tctctacttc ttttttgaga tgagacagta tagaagtttc ctcggttagc
    25081 tccagaaggg agaacccttt ttggataagt ttcgcatcat ccctacaaat cccaatacgg
    25141 acatagcaga tagccagcct atcgtagctt ttcttattct tggcgtcctc cagtaaagtg
    25201 tagcagattt gcttacacat gtttttatct tgattgtata gatagagtgt ggaaaggttt
    25261 aatagaattg tcattcgcaa gtcatataaa tgttgatagt ttttatagac ttctaggcgt
    25321 tgcaatattt ttccagtgat gagatggagg tattcaatgg gaaaactgaa aagaatggta
    25381 ttgaggattt ttagatcact ctcataccat gtatcttgtt tttcaatttt tttccaaagt
    25441 tttttgacaa cctgttctgc gtgttttgat agttcccctg ccccgtgttg acggagataa
    25501 ataacaactt caagcatatc tctgatttct tctataggga gatcgtggtg ggtcttgagg
    25561 tagtcttggc atttttgaaa taaattgaca agatcgctgg tcccgataat ggaacgcata
    25621 ttgagatagg tttgcataat ctctgtgcgt tgacttggtt gataaagttg acagatatat
    25681 tcaaactctt caaaactcat attgatttga cggagaagaa attccatatt ttcatatttt
    25741 ggggttgtct tgccactttc gatttttgat aagctggttc ttgagagaac acccccacag
    25801 acctcttctt gggtcagccc ctttgactca cgtatttctt tatagacctt tccgaaatca
    25861 taacgcatga ttttctcctt ttcgtgaaaa aagttaacaa acaataaaat tttgttaaaa
    25921 atattgtatc atagcaatgt aaaaagtaaa aaagaaagtc gaaataaatt tgtgaaaaaa
    25981 gttaacgtaa ttttaaaatg agcttaataa gaggtactat gtaggtagaa aataaagata
    26041 ggagaaaaag tatgaataaa aaaatatttt gtattctagt atgtattata tcattgatta
    26101 gtctggctat aatctttcca tggggctggc cgatataatg taagggagtt tgagttgtta
    26161 aaggaggctc agtccttggg caaaaatctg ctgtactaca atgcttggaa agatatcaag
    26221 aacaaagaat gatacggttg aaaataaatt aattcaagaa ctactgggca gtgattgagg
    26281 tttgggtgac atcaaagaaa agttagatga attctaaaga attgagtatt tctatgttaa
    26341 aaaaatatcc ttgtacgatg caacatgacc agtcagattg tgctgcggca gttgtttcaa
    26401 cagttctttt atcttacaaa aaggaactat caatcatgaa gattagggaa attattggta
    26461 cagacatgta tggaacgact gtcagtggta ttgtttcagg tctgaataag ttgaatttta
    26521 cagtaaaagc tgttcgagta gcactggaag atttgactcc aaaattaaca tttcctgcga
    26581 ttcttcaagt taagaatgat ttaggtcaaa atcattttgt ggtattacat agtatcaaaa
    26641 ggaatagtaa attttacgta gcagaccctg ctagtggcat acgcaagatg tcaagtgatg
    26701 aactgggaga aatttatcaa ggtattactc tttttatggt tccaaattcg gattttgaaa
    26761 gagggaaact aaagggaaaa ggacttcttg atttatttgg aaggttaatt tttaatcaaa
    26821 aaggattgat tagtacagtc atattagctt cctttgtttt aagtatcatt ggtattttat
    26881 cgagtctctt ttcaaaagtt atcatggacg aggtgattcc atatgcttta aaaaatagtc
    26941 tgtatatgtt tttgatagta tttggaatag tgtcgttctt acagactctt ctatctgcat
    27001 ttcgtcagca cgttcttttg tttctatctc gaaaaattga tataccggtt ttaatgggat
    27061 attatgacca tattattcat cttccttata gtttttttgg aagtcgtaga gttggtgatg
    27121 ttttaacaag atttcaagat gcgatgacga taaagaatgt gtttacgtca gtctctattt
    27181 cattagtcat ggatatcatc ttgtcagtta ttagtgcggt tgtcctttgg actattaatc
    27241 aatctttatt tctgatatta gtttttatgg ttattgttaa catcattctt atatactgtt
    27301 ttaaaaagcc ttataaaaaa attaatcatg aacaaatgga agcaaatgga cttcttaatt
    27361 cacagttaat tgaatctatt cgtaacattg ataccattaa gtctcagcat gatgaggaac
    27421 aacgtttaaa caaaattgaa gaaaaatttg ttcatacttt agaaattggt tataaagagg
    27481 gcgttttgca gaatattcaa tctacaatat cttcaatgac ctcaaccatg ggtgggttat
    27541 tatttatggg agtgggcgcc ttatttatca ttgatggaaa aatgactatt ggggacctct
    27601 tggtttttca gacattaagt caatatttta cagaacctat tcagaattta gttggcttgc
    27661 agttaacctt tcaagaggta caggttgcgg ttagtcggct tcaagaattg atggaagtag
    27721 atcgtgaaga cattgccttg gattatagta ttagagactt caccttatgt gatgacattg
    27781 aatttaaaga tgtaacattt gcctatggtt cacgccctcc tgttatcaag gactttaatt
    27841 tgcgaattaa acaaggagaa aaaatagctt ttgttggaga aagcggagca ggaaaaagta
    27901 cgctagttcg tttgttatta agatttataa atccgagtga ggggaaaatt cgtataggag
    27961 aaaatgactt atcagatctt gactatggta aactacgtaa gaaaatttcc tacattcctc
    28021 agaccataga actctttaca gggacaatta ttgataatct aaaaattggt aatccttctg
    28081 ttacatatga ggatatggtg agagtttgtc gtattgttgg tattcatgat acgattcaac
    28141 gtcttcaaaa tcgttatggc tcctttgtag aagaaggcgg tcaaaatttc tcgggtggag
    28201 agaaacaacg attggctatt gcaagagcac tactgagtaa agctgatttg tatatatttg
    28261 atgaggcaac ctctaactta gattcattta gtgaacagat tattcaggat ttaatcttta
    28321 ataaaataat agataagaca acaattgtag tagcccacag gctgtctaca attcttcgat
    28381 gtgataagat atgcttttta gaaaatggga ctattgtgga atatgggact catgaagaac
    28441 taatggcgaa aaatggaaag tatgctagaa tggttggttt gcagagcgtt caagtgaatc
    28501 aacaaattca gtcacaggct gtgttagata tagaggaggt tacttatggc taagttagag
    28561 gtaaaagata ataaaaaact ggtactaaag tcagttatct gtaaaaagtt acatgataca
    28621 aaagtagaag atgtagatca ggaaattaat aaatttcatc aacatttgca gttgttaaaa
    28681 gcacaaattt ttggtccatt aattgtaaaa agttgtggta ctactattca tgatgatgga
    28741 ttaataacga ctgattttga gttttatatt caagctcata atgctcaaca gtacagtaac
    28801 atttatgatg tacaggattc tatctctgtt ccatattgtt tatatgttcg ttttgaagac
    28861 agtccagagt atctacagta tgcgtattct aaattggatc tatatgtcta tgaaaatgat
    28921 attcaaacgg atgggattgt ctatacagtt tatgttaatt cttctcctga aaaaatggta
    28981 gtagatattt ttagaccaat tgtaagccta tgaaattata taataaatca gaattacgtt
    29041 attctcgtat tttctttgat aagagaccac cagcttttgc gtttattctc attatttcaa
    29101 ctgctattat cttaagcggt gcattggttg gcgcagctta tatacccaaa aactatattg
    29161 taaaagcgaa tggaaattca gttataacag gtacagagtt cctatcagca attggttcag
    29221 ggaaggtagt tactttacat aagtcagaag gagatatggt aaatgctgga gatgtcatta
    29281 tttcgttatc aagtggacaa gaaggtttac aagcgagctc tttaaataaa caattggaga
    29341 agttacgtgc aaaagaagct atctttcaaa aatttgaaca atcattaaat gagaaataca
    29401 atcatttatc taattctggt gaagaacagg aatattatgg gaaagttgaa tactatctgt
    29461 ctcagttaaa ctcggaaaat tataataatg gtacccagta ttcaaagatt caggatgaat
    29521 atacgaagtt gaataaaata acagctgaaa gaaatcagtt agatgccgac ttgcaagctc
    29581 tacaaaatga attgcttcaa cttcaacagc aaggagactc accttcttta tcagatacga
    29641 catcagctga tgataaagct aagttagaaa ctaagatatc agaaataaca acaaaaatcg
    29701 aagcattaaa aacaaatatt acttctaaga atagcgagat tgatagtcaa caaagcaata
    29761 ttaaggatat gaaccgtacc tataataatc caacttctca ggcttataat atttatgctc
    29821 aattaattag tgagttaggt actgctcgtt caaacaacaa taaaagtatt acagagcttg
    29881 aggctaatct tggagtggca acaggtcaag ataaagcaca tagtatatta gcgccaaatg
    29941 aaggtactct gcattatctg gtacctttga aacaaggaat gtctattcag caggggcaaa
    30001 cgatagcaga agtttcaggg aaagaaaaag gttactatgt agaagctttt gtacttgcga
    30061 gtgatatttc tcgtgtttcg aaaggagcaa aagctgatgt tgctattact ggtgtaaata
    30121 gtcaaaaata tggaacacta aagggacaag tcagacagat tgattcagga acaatttccc
    30181 aagaaacgaa agaggggaat attagcctct ataaagtcat gatagaatta gaaaccttaa
    30241 ctctaaaaca tggaagtgag acagtcgtcc tccaaaagga tatgccagtt gaagtgcgga
    30301 ttgtctatga taaagaaacc tatcttgatt ggattttaga aatgttaagt ttcaagcaat
    30361 aattggtttt aaacccctta ggtaacctat aaaaataaat aaggtagaga aaggatatct
    30421 tatctaggta gctaagtgat agaaacacag tcgacgatta cttgttagta aactatccta
    30481 accatgctta ataaaaaagg agaaaataaa tggaactcat attgccaaat aattatgttg
    30541 atcttgaaca agaagagatg atgtatcttg atggcggaga accaatgtca atttcggcca
    30601 ttgttgcctt ggctatcaca attggtggcg catcgtatag cacaggatat gtgttaggag
    30661 aaagagtcta ctattcagga tataaaaact ctgattatca aaaaaataag tggggtatta
    30721 ggggagcaat gctggctgca tttggagcaa taggtgcagt agttatgctc ggttttgaaa
    30781 atagatacta tgctttggtt actggtagag gataaaatgt taagagtaat agtagttatt
    30841 caatctttag taataatact gcttgctgtt gctttattat tatctcggaa aaactttgat
    30901 tcgttaaatg ttgttcttat aatgatgatc gtatcacaat tgttgttatt agtatatttg
    30961 ataaaattag ggaatcagtg attagctgtt atttgaatta agtaaactgt taagcttcaa
    31021 gcagtaactg gttttaaata tttaaaataa gataaaggaa ggaagtctaa tttaggtaac
    31081 taaacaaagc ctgcgatcac ttgttaggaa actatcctaa ccatgcttaa taaaaaagga
    31141 gaaaataaat ggaactcgta ttaccaaata attatgttgc tcttgagcaa gaagagatga
    31201 tgtatcttga tgggggagct tatttaagca agcgtgcttg tcaaggaatt tgcgcagctt
    31261 tagctatgag tccaggaact tttatagcat tagctggagc tgcagtttta accaaaaaac
    31321 taataaacta tattaaagtt ggaggccttg gaggttggct tattggtgca gcagcaggtg
    31381 tattggctgg ggcggcagga agaatagctt actgtattgg atatggtgct cttaatagag
    31441 gttgtgatat tagcgggaac ccttatcctt gggatggatt catatctgcg acagtaagat
    31501 gagtaatgta gataagattc gaaaaataca cattatcgta tgttggatgt atatattttt
    31561 atcattcagg gcgattataa atga
//
LOCUS       DAVLHC010000023        31007 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.023, whole genome shotgun sequence.
ACCESSION   DAVLHC010000023 DAVLHC010000000
VERSION     DAVLHC010000023.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 31007)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 31007)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..31007
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.023"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..401
                     /locus_tag="VXE25_001170"
     CDS             <1..401
                     /locus_tag="VXE25_001170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="alanine dehydrogenase"
                     /protein_id="HEV0771640.1"
                     /translation="KNNENRVALTPAGVHSLVSRGHRVLIETNAGLGSGFTDADYQKQ
                     GAEIVATAGEAWAAELVVKVKEPLSSEYGYLRDDLLLFTYLHMAAAPELADAMLAAKT
                     TGIAYETVRDNQGQLPLLVPMSEVAGRMAV"
     gene            402..815
                     /locus_tag="VXE25_001171"
     CDS             402..815
                     /locus_tag="VXE25_001171"
                     /inference="COORDINATES: protein motif:HMM:NF013430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-binding protein"
                     /protein_id="HEV0771641.1"
                     /translation="MGAHFLTKQAGGSGVLLGGVPGVPKGKVTIIGDGVVGTHAARIA
                     LGLGAQVTILDISAKRLSVLEEVFGSQIQTLMSNSFNIEASVRDADVVIGAILIPGAK
                     APELVTDEMVKQMRPGSVSLTLLLTKVALSKQLTV"
     gene            761..1087
                     /locus_tag="VXE25_001172"
     CDS             761..1087
                     /locus_tag="VXE25_001172"
                     /inference="COORDINATES: protein motif:HMM:NF013430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771642.1"
                     /translation="MVDIAVDQGGLIETADRVTTHDEPVYEKHGVLHYAVANIPGAVA
                     RTSTIALTNVTLPYIEALAGKGFAQAISEDEGLRQGVTTYQGYLTSLPVAQGLNRDYT
                     DINDLV"
     gene            complement(1454..1714)
                     /locus_tag="VXE25_001173"
                     /pseudo
     CDS             complement(1454..1714)
                     /locus_tag="VXE25_001173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003069408.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="TfoX/Sxy family protein"
     gene            complement(1717..2217)
                     /locus_tag="VXE25_001174"
     CDS             complement(1717..2217)
                     /locus_tag="VXE25_001174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000566985.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0771643.1"
                     /translation="MIDQLSKYYSCRILTEKDIPSILSLYESNPLYFQHCPPEPNFAT
                     VKEDMLCLPEGKAKADKFFVGFWNGSDLVAVMDFVYAYPDEETVFIGLFMVDQAYQRK
                     GIGSHIVTEALAYFAKNFRKARLAYVKGNPQSQHFWEKQGFKSIGCEVKQELYTVVIA
                     EQSLED"
     gene            2253..2432
                     /locus_tag="VXE25_001175"
     CDS             2253..2432
                     /locus_tag="VXE25_001175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771644.1"
                     /translation="MTQEDALIVISHIKVLSIVPNRCLRPLDKTFSLYNWIFLSQKYI
                     LLQANFLKISRVQLQ"
     gene            complement(2410..3378)
                     /locus_tag="VXE25_001176"
     CDS             complement(2410..3378)
                     /locus_tag="VXE25_001176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PhoH family protein"
                     /protein_id="HEV0771645.1"
                     /translation="MKEHSIDIQLSHPDDLFHLFGSNERHLRLMEEELDVVIHARTEI
                     VQVLGEESACEEARQVIQALMVLVNRGMTVGTPDVVTAISMVKNDEIDKFVALYEEEI
                     IKDNTGKPIRVKTLGQKLYVDSVKQHDVTFGIGPAGTGKTFLAVTLAVTALKRGQVKR
                     IILTRPAVEAGESLGFLPGDLKEKVDPYLRPVYDALYQILGKDQTTRLMEREIIEIAP
                     LAYMRGRTLDDAFVILDEAQNTTIMQMKMFLTRLGFHSKMIVNGDISQIDLPRNVKSG
                     LIDAQEKLKNIHQIDFVHFSAKDVVRHPVVAQIIRAYEYSTEVAHD"
     gene            complement(3464..3679)
                     /locus_tag="VXE25_001177"
     CDS             complement(3464..3679)
                     /locus_tag="VXE25_001177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002894860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YozE family protein"
                     /protein_id="HEV0771646.1"
                     /translation="MRKSFYTWLMTERNPKSNSPKAILADLAFEEAAFPKHTDDFDEV
                     SRFLEEHASFSFNLGDFDAIWQEYLEH"
     gene            complement(3688..4542)
                     /gene="cvfB"
                     /locus_tag="VXE25_001178"
     CDS             complement(3688..4542)
                     /gene="cvfB"
                     /locus_tag="VXE25_001178"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001095444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding virulence regulatory protein CvfB"
                     /protein_id="HEV0771647.1"
                     /translation="MNTNLASFIVGLIIDENDRFYFVQKDGQTYALAKEEGQHTVGDT
                     VKGFAYTDMKQKLRLTTLEVTATQDQFGWGRVTEVRKDLGVFVDTGLPDKEIVVSLDI
                     LPELKELWPKKGDQLYIRLEVDKKDRIWGLLAYQEDFQRLARPAYNNMQNQNWPAIVY
                     RLKLSGTFVYLPENNMLGFIHPSERYAEPRLGQVLDARVIGFREVDRTLNLSLKPRSF
                     EMLENDAQMILTYLESNGGFMTLNDKSSPDDIKATFGISKGQFKKALGGLMKAGKIKQ
                     DQFGTELI"
     gene            complement(4602..5159)
                     /gene="frr"
                     /locus_tag="VXE25_001179"
     CDS             complement(4602..5159)
                     /gene="frr"
                     /locus_tag="VXE25_001179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006148672.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome recycling factor"
                     /protein_id="HEV0771648.1"
                     /translation="MANAIIEKAKERMTQSHQSLAREFGGIRAGRANASLLDRVHVEY
                     YGVETPLNQIASITIPEARVLLVTPFDKSSLKDIERALNASDLGITPANDGSVIRLVI
                     PALTEETRRDLAKEVKKVGENAKVAVRNIRRDAMDEAKKREKAKEITEDELKTLEKDI
                     QKVTDDAVKHIDDMTANKEKELLEV"
     gene            complement(5168..5905)
                     /locus_tag="VXE25_001180"
     CDS             complement(5168..5905)
                     /locus_tag="VXE25_001180"
                     /EC_number="2.7.4.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000013002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UMP kinase"
                     /protein_id="HEV0771649.1"
                     /translation="MANPKYKRILIKLSGEALAGERGVGIDIQTVQTIAKEIQEVHSL
                     GIEIALVIGGGNLWRGEPAAEAGMDRVQADYTGMLGTVMNALVMADSLQQVGVDTRVQ
                     TAIAMQQVAEPYVRGRALRHLEKGRIVIFGAGIGSPYFSTDTTAALRAAEIEADAILM
                     AKNGVDGVYNADPKKDKTAVKFEELTHRDVINKGLRIMDSTASTLSMDNDIDLVVFNM
                     NQPGNIKRVVFGENIGTTVSNNIEEKE"
     gene            complement(5989..7323)
                     /gene="trmFO"
                     /locus_tag="VXE25_001181"
     CDS             complement(5989..7323)
                     /gene="trmFO"
                     /locus_tag="VXE25_001181"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000083696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylenetetrahydrofolate--tRNA-(uracil(54)-
                     C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO"
                     /protein_id="HEV0771650.1"
                     /translation="MSQSYINVIGAGLAGSEAAYQIAERGIPVKLYEMRGVKSTPQHK
                     TDNFAELVCSNSLRGDALTNAVGLLKEEMRRLGSVILESAEATRVPAGGALAVDRDGF
                     SQMVTEKVANHPLIEVVRDEITELPTDVITVIATGPLTSDALAEKIHALNDGAGFYFY
                     DAAAPIIDVNTIDMSKVYLKSRYDKGEAAYLNAPMTKQEFMDFHEALVNAEEAPLNSF
                     EKEKYFEGCMPIEVMAKRGIKTMLYGPMKPVGLEYPDDYTGPRDGEFKTPYAVVQLRQ
                     DNAAGSLYNIVGFQTHLKWGEQKRVFQMIPGLENAEFVRYGVMHRNSYMDSPNLLEQT
                     YRSKKQPNLFFAGQMTGVEGYVESAASGLVAGINAARLFKEESEVIFPETTAIGSLAH
                     YITHADSKHFQPMNVNFGIIKELEGERIRDKKARYEKIAERALADLEEFLTV"
     gene            complement(7568..7808)
                     /locus_tag="VXE25_001182"
                     /pseudo
     CDS             complement(7568..7808)
                     /locus_tag="VXE25_001182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001244258.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit delta"
     gene            7818..8622
                     /locus_tag="VXE25_001183"
     CDS             join(7818..8186,8188..8622)
                     /locus_tag="VXE25_001183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /ribosomal_slippage
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS5 family transposase"
                     /protein_id="HEV0771651.1"
                     /translation="MNDEASKQLTDARFKRLVGVQRTTFEEMLAVLKTAYQLKHAKGG
                     RKPKLSLEDLLMATLHYVREYRTYEEIAADFGIHESNLLRRSQWVEVTLVQSGFTISR
                     TPLSSEDTVMIDATKVKINRPKKELANDSGKKKCHAMKSQAIVTSQGRIVSLDITVNY
                     CHDMKLFKMSRRNIGQAGKILADSGYQGLMKIYPQAQTPRKSSKLKPLIAEDKAYNHA
                     LSKERSKVENIFAKVKTFKMFSTTYRNHRKRFGLRMNLSAGIINHELGF"
     gene            complement(8611..9258)
                     /locus_tag="VXE25_001184"
     CDS             complement(8611..9258)
                     /locus_tag="VXE25_001184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000345255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="HEV0771652.1"
                     /translation="MDFEYFYNREAERFNFLKVPEILVDREEFRGLSAEAIILYSILL
                     KQTGMSFKNNWIDKEGRVFIYFTVEEIMKRRNISKPTAIKTLDELDVKKGIGLIERVR
                     LGLGKPNIIYVKDFMSIFQVKENDLQKSKNLTSEVKDFNLRSKENELQEVKNLDSNYI
                     ENNKSKYSKREYSFGENGLGTFQNVFLAAEDISDLQIIMNSQLENYIRLPAKLES"
     gene            complement(9367..9885)
                     /locus_tag="VXE25_001185"
     CDS             complement(9367..9885)
                     /locus_tag="VXE25_001185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013852041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ClbS/DfsB family four-helix bundle protein"
                     /protein_id="HEV0771653.1"
                     /translation="MRTYENKEELKAEIEKTFEKYILEFDNIPENLKDKRADEVDRTP
                     AENLAYQVGWTNLVLKWEEDERKGLQVKTPSDKFKWNQLGELYQWFTDTYAHLSLQEL
                     KAKLNENINSISAMIDSLSEEELFEPHMRKWADEATKTATWEVYKFIHVNTVAPFGTF
                     RTKIRKWKKIVL"
     gene            complement(10112..10981)
                     /gene="rsmI"
                     /locus_tag="VXE25_001186"
     CDS             complement(10112..10981)
                     /gene="rsmI"
                     /locus_tag="VXE25_001186"
                     /EC_number="2.1.1.198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001166894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA
                     (cytidine(1402)-2'-O)-methyltransferase"
                     /protein_id="HEV0771654.1"
                     /translation="MQIQKSFKGQSPYGKLYLVATPIGNLDDMTFRAIQTLKEVDWIA
                     AEDTRNTGLLLKHFDISTKQISFHEHNAKEKIPDLIGFLKAGQSIAQVSDAGLPSISD
                     PGHDLVKAAIEEEIAVVTVPGASAGISALIASGLAPQPHIFYGFLPRKSGQQKQFFDS
                     KKDYPETQIFYESPHRVADTLENMLEVYGDRSVVLVRELTKIYEEYQRGTISELLESI
                     SETSLKGECLLIVEGASKGVEEKDEEDLFLEIQARIQQGMKKNQAIKEVAKIYQWNKS
                     QLYAAYHDWEEKQ"
     gene            complement(10984..11301)
                     /gene="yabA"
                     /locus_tag="VXE25_001187"
     CDS             complement(10984..11301)
                     /gene="yabA"
                     /locus_tag="VXE25_001187"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA replication initiation control protein YabA"
                     /protein_id="HEV0771655.1"
                     /translation="MDKKELFDALDDFSQQLLVTLADVEAIKKNLKSLVEENTALRLE
                     NSKLRERLGEVEADAPVKAKHVRESVRRIYRDGFHVCNDFYGQRREQDEECMFCDELL
                     YRE"
     gene            complement(11341..12231)
                     /locus_tag="VXE25_001188"
     CDS             complement(11341..12231)
                     /locus_tag="VXE25_001188"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000806705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit delta'"
                     /protein_id="HEV0771656.1"
                     /translation="MKQDQLKAWQPAQFDRFVRILEQDQLNHAYLFSGFFGSLEMAQF
                     LAKSLFCTDKVGVLPCEKCRSCKLIEQEEFPDVTLIKPVNQVIKTERIRELVGQFSQA
                     GIESQQQVFIIEQADKMHPNAANSLLKVIEEPQSEVYIFFLTSDEEKMLPTIRSRTQI
                     FHFKKQEEKLILLLEQMGLVKKKATLLTKFSQSRAEAEKLANQASFWTLVDESERLLT
                     WLVAKKKESYLQVAKLANLADDKEKQDQVLRILEVLCGQDLLQVRVRVILQDLLEARK
                     MWQANVSFQNAMEYLVLKEI"
     gene            complement(12228..12866)
                     /locus_tag="VXE25_001189"
     CDS             complement(12228..12866)
                     /locus_tag="VXE25_001189"
                     /EC_number="2.7.4.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dTMP kinase"
                     /protein_id="HEV0771657.1"
                     /translation="MSKGFLVSLEGPEGAGKTSVLEALLPILEEKGVKVLTTREPGGV
                     LIGEKIREVILDPSHTQMDAKTELLLYIASRRQHLVEKVLPALEAGKLVIMDRFIDSS
                     VAYQGFGRGLDIEAIDWLNQFATDGLKPDLTLYFDIEVEEGLARIAANSDREVNRLDL
                     EGLDLHKKVRQGYLSLLEKEGNRIVKIDASLPLEQVVETTKAVLFDGMGLAK"
     gene            complement(13088..13885)
                     /gene="proC"
                     /locus_tag="VXE25_001190"
     CDS             complement(13088..13885)
                     /gene="proC"
                     /locus_tag="VXE25_001190"
                     /EC_number="1.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254731.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrroline-5-carboxylate reductase"
                     /protein_id="HEV0771658.1"
                     /translation="MKIGFIGLGNMGASLAKSVLQARPSDEILLANRSQVKVDAFIAN
                     FGGQTSNNEEIFEEADVIFLGVKPAQFSELLSQYQTILEKRESLLLISMAAGLTLEKL
                     ASLIPSQHRIIRMMPNTPASIGQGVISYALSPNCRAEDSELFCQLLAKAGLLVELGES
                     LINAATGLAGCGPAFVYLFIEALADAGVQTGLPRETALKMAAQTVVGAGQLVLESQQH
                     PGVLKDQVCSPGGSTIAGVASLEAHAFRGTVMDAVHQAYKRTQELGK"
     gene            complement(13889..15151)
                     /locus_tag="VXE25_001191"
     CDS             complement(13889..15151)
                     /locus_tag="VXE25_001191"
                     /EC_number="1.2.1.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate-5-semialdehyde dehydrogenase"
                     /protein_id="HEV0771659.1"
                     /translation="MVSRQEQFEQVQAVKKSINTASEEVKNQALLAMADHLVAATEEI
                     LAANALDMAAAKGKISDVMLDRLYLDADRIEAMARGIREVVALPDPIGEVLETSQLEN
                     GLVITKKRVAMGVIGIIYESRPNVTSDAAALTLKSGNAVVLRSGKDAYQTTHAIVTAL
                     KKGLETTTIHPNVIQLVEDTSRESSYAMMKAKGYLDLLIPRGGAGLINAVVENAIVPV
                     IETGTGIVHVYVDKDADEDKALSIINNAKTSRPSVCNAMEVLLVHENKAASILPRLDQ
                     MLVAERKEAGLEPIQFRLDSKASQFVSGQAAETQDFDTEFLDYVLAVKVVSSLEEAVA
                     HIESHSTHHSDAIVTENAEAAAYFTDQVDSAAVYVNASTRFTDGGQFGLGCEMGISTQ
                     KLHARGPMGLKELTSYKYVVTGDGQIRE"
     gene            complement(15161..16291)
                     /locus_tag="VXE25_001192"
     CDS             complement(15161..16291)
                     /locus_tag="VXE25_001192"
                     /EC_number="2.7.2.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004240022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate 5-kinase"
                     /protein_id="HEV0771660.1"
                     /translation="MNNRSETMKYKRIVFKVGTSSLTNEDGSLSRSKVKDITQQLAML
                     HEAGHELILVSSGAIAAGFGALGFKKRPTKIADKQASAAVGQGLLLEEYTTNLLLRQI
                     VSAQILLTQDDFVDKRRYKNAHQALSVLLNRGAIPIINENDSVVIDELKVGDNDTLSA
                     QVAAMVQADLLVFLTDVDGLYTGNPNSDPRAKRLERIETINREIIDMAGGAGSSNGTG
                     GMLTKIKAATIATESGVPVYICSSLKSDSMIEAAEETEDGSYFVAQEKGLRTQKQWLA
                     FYAQSQGSIWVDKGAAEALSQHGKSLLLSGIVEAEGVFSYGDIVTVFDKESGKSLGKG
                     RVQFGASALEDMLRSQKAKGVLIYRDDWISITPEIQLLFTEF"
     gene            complement(16371..18254)
                     /gene="cbpE"
                     /locus_tag="VXE25_001193"
                     /gene_synonym="pce"
     CDS             complement(16371..18254)
                     /gene="cbpE"
                     /locus_tag="VXE25_001193"
                     /gene_synonym="pce"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphorylcholine esterase CbpE"
                     /protein_id="HEV0771661.1"
                     /translation="MKKKLTSLALVGAFLGLSWYGNVQAQESSGNKIHFINVQEGGSD
                     AIILESNGHFAMVDTGEDYDFPDGSDSRYPWRQGINTTYKHVLTDRVFRRLKELGVQK
                     LDFILVTHTHSDHIGNVDELLSTYPVDRVYLKKYSDSRITNSERLWDNLYGYDKVLQT
                     AAEKGVSVIQNITQGDAHFQFGDMDIQLYNYENETDSSGELKKIWDDNSNSLISVVKV
                     NGKKIYLGGDLDNVHGAEDKYGPLIGKVDLMKFNHHHDTNKSNTKDFIKNLSPSLIVQ
                     TSDSLPWKNGVDSEYVNWLKERGIERINAASKDYDATVFDIRQDGLVNISTSYKPIPS
                     FQAGWHKSSYGNWWYQAPDSTGEYAVGWNEIKGEWYYFNQTGILLQNQWKKWNNRWFY
                     LTDSGVAAKNWKKIAGIWYYFNKENQMEIGWIQDKEQWYYLDVDGSMKTGWLQYKGQW
                     YYFAPSGEMKTGWVKDKEAWYYMDSTGIMKTGEIEVAGHHYYLEESGAMKQGWLKKAN
                     DWYFYKTDGSRAIGWIKDKDKWYFLKENGQLLVNGKTPEGYTVDSSGAWLVDVPIEKS
                     ATIKTTSHSEIKESKEVVKKDLENKETSQHESVTNSSTSQDLTSSTSQSSETSVNKSE
                     SEQ"
     gene            complement(18257..19144)
                     /locus_tag="VXE25_001194"
     CDS             complement(18257..19144)
                     /locus_tag="VXE25_001194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HEV0771662.1"
                     /translation="MEIKIETGGLRLDKALSDLSELSRSLANEQIKSGQVLVNGQVKK
                     AKYTVQEGDVVTYHVPEPEVLEYVAEDLPLEIVYQDEDVAVVNKPQGMVVHPSAGHTS
                     GTLVNALMYHIKDLSGINGVLRPGIVHRIDKDTSGLLMIAKNDDAHLALAQELKDKKS
                     LRKYWAIVHGNLPNDRGVIEAPIGRSEKDRKKQAVTAKGKPAVTRFHVLERFGDYSLV
                     ELQLETGRTHQIRVHMAYIGHPVAGDEVYGPRKTLKGHGQFLHAKTLGFTHPRTGKTL
                     EFKADIPEIFKETLERLRK"
     gene            complement(19134..19595)
                     /locus_tag="VXE25_001195"
     CDS             complement(19134..19595)
                     /locus_tag="VXE25_001195"
                     /EC_number="3.4.23.36"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase II"
                     /protein_id="HEV0771663.1"
                     /translation="MKKRAIVAVIVLLLIGLDQLVKSYIVQQIPLGEVRSWIPNFVSL
                     TYLQNRGAAFSILQDQQLLFAVITLVVVIGAIWYLHKHMEDSFWMVLGLTLIIAGGLG
                     NFIDRVSQGFVVDMFHLDFINFAIFNVADSYLTVGVIILLIAMLKEEINGN"
     gene            complement(19592..20500)
                     /locus_tag="VXE25_001196"
     CDS             complement(19592..20500)
                     /locus_tag="VXE25_001196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001025716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HEV0771664.1"
                     /translation="MNIQQLRYVVAIANSGTFREAAEKMYVSQPSLSISVRDLEKELG
                     FKIFRRTSSGTFLTRRGMEFYEKAQELVKGFDIFQNQYANPEEEKDEFSVASQHYDFL
                     PPTITAFSERYPDYKNFRIFESTTVQILDEVAQGHSEIGIIYLNNQNKKGIMQRVEKL
                     GLEVIELIPFHTHIYLREGHPLAQKDELVMEDLADLPTVRFTQEKDEYLYYSENFVDT
                     SASSQMFNVTDRATLNGILERTDAYATGSGFLDSDSVNGITVIRLKDNLDNRMVYVKR
                     EEVELSQAGTLFVEVMQEYFDQKRKS"
     gene            20493..20690
                     /locus_tag="VXE25_001197"
                     /pseudo
     CDS             20493..20690
                     /locus_tag="VXE25_001197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842783.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
     gene            complement(20742..21413)
                     /locus_tag="VXE25_001198"
     CDS             complement(20742..21413)
                     /locus_tag="VXE25_001198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000746014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEV0771665.1"
                     /translation="MKKRAIQILLVLSLIFYKSTWFWRLFNYLAKPYLPASREFFQIL
                     LLMESGVLFLAVIYLLVFAGKKIFHFKWQLRYFIYLLLGYIISYMSDFLFSYFISPPS
                     NQISLNETIEMMGRQEFPYFLLIVCFIAPIAEELIYRGVIMTTFFKNSPWYGDVLLSA
                     IIFGYIHINFALTPLAFFIYASGGLILALLYRMTKNLYYPILVHILINITAFWDVWLL
                     LFSGS"
     gene            complement(21467..21688)
                     /locus_tag="VXE25_001199"
     CDS             complement(21467..21688)
                     /locus_tag="VXE25_001199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000602450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SP_0924 family bacteriocin-like peptide"
                     /protein_id="HEV0771666.1"
                     /translation="MILMTKNINLTNEELELIQGGADPYGKNPNGRYDWEIEPVLTLL
                     VHGFCPRGTDDLGYIGGGNHLCKGSAARF"
     gene            21960..22769
                     /locus_tag="VXE25_001200"
     CDS             21960..22769
                     /locus_tag="VXE25_001200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000593565.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEV0771667.1"
                     /translation="MIKLLALDMDGTLLNEAKEIPQAHITAIHKAIEKGVKLVLCTGR
                     PLFGVLPYYKKLELDLQNEYIIVNNGCSTHQTSDWGLVDWQELSPADIEYLYDLAEKS
                     DVQLTLFDESHYFVLGGKPNQVIENDAKLVFSDLTEISLEEATSGKFRMFQGMFLGTK
                     EQTDDFEQRFAEELCQRFSGVRSQPVIYEAMPLGTTKATALSRLAEILKIDSSEIMAM
                     GDANNDIEMLQFAGLGIAMGNASDYVKSLADAVTSSNEEDGVARAIEKYIL"
     gene            complement(22950..23825)
                     /gene="aguB"
                     /locus_tag="VXE25_001201"
     CDS             complement(22950..23825)
                     /gene="aguB"
                     /locus_tag="VXE25_001201"
                     /EC_number="3.5.1.53"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001246759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-carbamoylputrescine amidase"
                     /protein_id="HEV0771668.1"
                     /translation="MRNVRVATIQMQCAKDVATNIQTAERLVRQAAEQGAQIILLPEL
                     FEHPYFCQERQYDYYQYAQSVAENTAIQHFKVIAKELQVVLPISFYEKDGNVLYNSIA
                     VIDADGEVLGVYRKTHIPDDHYYQEKFYFTPGNTGFKVWNTRYAKIGIGICWDQWFPE
                     TARCLALNGAELLFYPTAIGSEPILDTDSCGHWQRTMQGHAAANIVPVIAANRYGLEE
                     VTPSEENGGQSSSLDFYGSSFMTDETGAILERAERQEEAVLLATYDLDKGASERLNWG
                     LFRDRRPEMYRQITD"
     gene            complement(23835..24920)
                     /gene="aguA"
                     /locus_tag="VXE25_001202"
     CDS             complement(23835..24920)
                     /gene="aguA"
                     /locus_tag="VXE25_001202"
                     /EC_number="3.5.3.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="agmatine deiminase"
                     /protein_id="HEV0771669.1"
                     /translation="MMDSPKKLGYHMPAEYEPHHGTLMIWPTRPGSWPFQGKAAKRAF
                     TQIIETIAEGERVYLLVEQAYLSEAQSYLGDKVVYLDIPTNDAWARDTGPTILVNDKG
                     KKLAVDWAFNAWGGTYDGLYQDYEEDDQVASRFAEALERPVYDAKPFVLEGGAIHSDG
                     QGTILVTESCLLSPGRNPNLTKEEIENTLLESLGAEKVIWLPYGIYQDETNEHVDNVA
                     AFVGPAELVLAWTDDENDPQYAMSKADLELLEQETDAKGCHFTIHKLPIPAVRQVVTE
                     EDLPGYIYEEGEEKRYAGERLAASYVNFYIANKAVLVPQFEDVNDQVALDILSKCFPD
                     RKVVGIPARDILLGGGNIHCITQQIPE"
     gene            complement(24917..26044)
                     /gene="nspC"
                     /locus_tag="VXE25_001203"
     CDS             complement(24917..26044)
                     /gene="nspC"
                     /locus_tag="VXE25_001203"
                     /EC_number="4.1.1.96"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carboxynorspermidine decarboxylase"
                     /protein_id="HEV0771670.1"
                     /translation="MKLEQVPTPAYVIDLAKLEANCRILQYVQEEAGCKVLLAQKAYS
                     LYKTYPLISQYLSGTTASGLYEAKLAREEFPGEVHVFAPAFKDEDMEELLGITDHIVF
                     NSERQLRKHGSRCREAGVSVGLRLNPQCSTQGDHALYDPCAPGSRFGVTIDKIPSDLL
                     DLVDGLHFHTLCEQGADDLQTTLKEVEEQFGPYLHEVKWLNMGGGHHITREGYDVDLL
                     ISEIKRIRKTYNLEIYIEPGEAIALNAGYLATEVLDIVENGMEILVLDASATCHMPDV
                     LEMPYRPPLRNGFEAQEKAHTYRLSSNTCLTGDVIGDYSFENPVQIGDRLYFQDMAIY
                     SFVKNNTFNGIGLPSLYLMDEQGDCSLLKAFGYQDFKGRLS"
     gene            complement(26044..27303)
                     /locus_tag="VXE25_001204"
     CDS             complement(26044..27303)
                     /locus_tag="VXE25_001204"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000088792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="saccharopine dehydrogenase family protein"
                     /protein_id="HEV0771671.1"
                     /translation="MSRLLVIGCGGVAQVAISKICQDSETFTEIMIASRTKSKCDDLK
                     AKLEGKTSTKIETAALDADKVEEVITLIESYKPEAVLNVALPYQDLTIMDACLATGVH
                     YIDTANYEAEDTEDPEWRAIYEKRCKELGFTAYFDYSWQWAYQEKFKEAGLTALLGSG
                     FDPGVTSVFSAYALKHYFDEIHYIDILDCNGGDHGYPFATNFNPEINLREVSAPGSYW
                     EDGKWVEVEAMSIKREYDFPQVGQKDMYLLHHEEIESLAKNIPGVKRIRFFMTFGQSY
                     LTHMKCLENVGLLRTDTINFNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGV
                     KDGVKKTIYIYNVCDHQECYAEVGSQAISYTTGVPAMIGTKLVMNGTWKQAGVYNLEE
                     LDPDPFMEALNEYGLPWVVVENPQMVD"
     gene            complement(27300..28160)
                     /gene="speE"
                     /locus_tag="VXE25_001205"
     CDS             complement(27300..28160)
                     /gene="speE"
                     /locus_tag="VXE25_001205"
                     /EC_number="2.5.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyamine aminopropyltransferase"
                     /protein_id="HEV0771672.1"
                     /translation="MDLWFSEVHTPDVKLSLRTAKQLYAGKSEWQDIEVLDTPAFGKI
                     LILNGHVLFSDADDFVYNEMTVHVPMAVHPNPKKVLVIGGGDGGVAQVLTLYPELEQI
                     DIVEPDEMLVEVCREYFPDFAAGLDDPRVTIYYQNGLRFLRNCEDDYDIIINDATDPF
                     GHTEGLFTKEFYGNSYRALKEDGIMIYQHGSPFFDEDESACRSMHRKVNQAFPISRVY
                     QAHIPTSPAGYWLFGFASKKYHPVKDFDKEGWKKRQLFTEYYTANLHVGAFMLPKYVE
                     DILEEEEGKK"
     gene            28541..29130
                     /locus_tag="VXE25_001206"
                     /pseudo
     CDS             28541..29130
                     /locus_tag="VXE25_001206"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809094.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(29096..30571)
                     /locus_tag="VXE25_001207"
     CDS             complement(29096..30571)
                     /locus_tag="VXE25_001207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000661022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HEV0771673.1"
                     /translation="MKELDQNQAPIYEALVKLRKKRIVPFDVPGHKRGRGNPELVELL
                     GEKCVGIDVNSMKPLDNLGHPISIIRDAEELAADAFGASHAFLMIGGTTSSVQTMILA
                     TCKAGDKIILPRNVHKSAINALVLCGAIPIYIEMSVDPKIGIALGLENDRVAQAIKDH
                     PDAKAILINNPTYYGICSDLKGLTEMAHEAGMMVLVDEAHGAHLHFTGKLPISAMDAG
                     ADMAAVSMHKSGGSLTQSSLLLIGEQMNPEYVRQIINLTQSTSASYLLMASLDISRRN
                     LALRGKESFEEVIELSEYARHEINAIGGYYAYSKELIDGVSVCDFDVTKLSVYTQGIG
                     LTGIEVYDLLRDEYDIQIEFGDIGNILAYISIGDRIQDIERLVGALADIKRLYSRDGK
                     DLIAGEYIQPELVLSPQEAFYSARKSLTLDDSVGQVCGEFVMCYPPGIPILAPGERIT
                     REIVDYIQFAKERGCSLQGTEDPEVNHINVIKRKTNYKKSQ"
BASE COUNT         8962 a         7083 c         5687 g         9275 t
ORIGIN      
        1 ttaaaaataa cgaaaaccgt gtcgccctca cacctgcagg tgttcatagc ttagttagtc
       61 gtggtcatcg tgtccttatc gaaacaaatg ctggtctcgg ttctggcttt actgatgctg
      121 actatcaaaa gcaaggagct gagattgtcg ctactgctgg tgaagcttgg gcagcagagt
      181 tggttgtgaa agtaaaagaa cctttaagtt ctgaatacgg ttacttgcgc gacgatcttc
      241 ttctcttcac ctacttgcac atggccgctg ctccagaatt agcagatgct atgttagcag
      301 caaaaacaac aggaattgcc tatgaaactg ttcgtgacaa tcaaggacaa ctaccgctcc
      361 tcgttcctat gagtgaggtt gcaggtcgta tggctgttta aatcggagct cacttcctta
      421 ctaagcaagc tggtggctct ggtgttctac ttggtggtgt accaggtgtt ccaaaaggaa
      481 aagtaactat catcggtgat ggtgtcgtcg gtacacatgc tgcccgcatc gcccttggtc
      541 ttggtgctca agtgactatt ttagatatta gtgccaagcg tctctcagtt ctagaagaag
      601 tctttggaag tcaaattcaa actcttatgt ctaattcatt caacattgaa gcaagtgtga
      661 gagatgctga tgtggtgatt ggagccattc tcatccctgg tgcaaaagca ccggaattgg
      721 tgacagatga gatggtcaaa caaatgcgtc caggctctgt atcgttgaca ttgctgttga
      781 ccaaggtggc cttatcgaaa cagctgaccg tgtgacaacg cacgatgaac ccgtctatga
      841 aaaacacggt gttctccact atgccgttgc caatatccct ggtgcggttg cccgcacttc
      901 aaccatcgcc ctaaccaatg tcactcttcc ttatatcgaa gctttggctg gcaaaggatt
      961 cgcacaagca atctctgaag atgaaggctt gcgtcaaggt gtgaccactt atcaaggtta
     1021 cttgactagc ctaccagttg ctcaaggact taatcgtgac tacactgata tcaatgattt
     1081 agtataaatt ttgaaaagaa aagggtgact tcgcaagtcc tacccactgt gctttgtgtc
     1141 atcagctatt acatcgttgg tttattgtac tgtatacttt gcaactggag actttcgttc
     1201 cagactcaat tgtgcataag aaactctaaa ttgaataaag tcaacagagt ttcgcccaac
     1261 cacttcgtct tgtaatgaca attatataaa ccaaaggaag ctgagctctt tagtcccagc
     1321 ttctttttat atataaaatt ttacccgtgc aaagacaggg ccttagcaga cttctttttt
     1381 acttcgttca cccttgcttt ttctttttag gtttgggcgt tggcagttgg ttatacatag
     1441 ctaaaatcag gtcttataga aacatcttat tatcaagttc ttccactcaa atcatttctt
     1501 tggcaccttt gtatggaaac tcaaaagaag attggtcaat cttatctaag actgcttgca
     1561 cgggtttaac taaaaagcga tcgtcataaa tgccgccaat aatcttgccg cggaagtaaa
     1621 gaatatactc ccccatcatg gaacggtaag tcacatcatc taatcctgat aattgttcca
     1681 aaacaaattc caaatagttc ttacttgatg ccatttctaa tcttctaggc tctgttcagc
     1741 gataacaacc gtatagagtt cttgcttaac ctcgcatcca attgatttaa agccctgctt
     1801 ttcccaaaaa tgctgagatt gcggatttcc cttaacataa gccaaacgtg cctttcgaaa
     1861 gttcttagca aaataagcta gtgcttctgt cacaatatga ctaccaatcc cttttctctg
     1921 ataggcttga tcaaccataa acaaaccaat aaaaacagtc tcctcatcag gatatgcata
     1981 gacaaaatcc ataacagcca caaggtcaga tccattccaa aatccaacaa aaaacttatc
     2041 agccttagct ttaccttcag gtagacaaag catgtcctct tttacagttg caaaatttgg
     2101 ctctggtgga caatgctgaa aatacagagg attactttca tataaagata aaatacttgg
     2161 aatatccttt tcagttagta tcctacaact gtaatactta gatagttggt caatcatctt
     2221 ttcaaattcc tactttcttg tgccctgtga ttatgacaca ggaagatgca ctgatcgtca
     2281 tcagccacat aaaagttctt tccatcgtgc ctaatcgttg tctcagacct ttggataaaa
     2341 cctttagcct atacaactgg attttcctct ctcaaaagta tattcttttg caggcgaact
     2401 tcctcaaaat cagtcgtgtg caacttcagt agaatattca taggctcgga taatctgagc
     2461 gacaactgga tggcgaacca catccttggc tgaaaaatga acaaagtcaa tctgatggat
     2521 gttcttgagt ttctcttgag catcaatcaa accggacttg acattacgtg gcaggtcaat
     2581 ctgactgata tctccattga caatcatctt agaatgaaag cctaaacgcg tcaagaacat
     2641 cttcatctgc atgatggtcg tgttttgcgc ctcatcgaga atgacaaagg catcatccaa
     2701 ggtccggcca cgcatatagg caaggggcgc aatttcgata atttcacgct ccatgagacg
     2761 agtcgtttgg tctttcccca gaatctgata caaggcatca taaacaggtc taaggtaagg
     2821 atctaccttc tccttaagat cacccggaag aaaacctaga ctctctcctg cttccaccgc
     2881 tggacgtgtc aagataatcc gcttgacttg cccacgttta agggcagtca ctgccaaagt
     2941 aactgcaaga aaggtcttcc ccgtccctgc aggcccaatt ccaaaggtca catcatgctg
     3001 tttgacactg tccacataaa gtttttgacc taacgtttta acgcggatcg gtttcccagt
     3061 attatccttg ataatttctt cttcgtaaag ggcgacaaac ttatcaattt catcgttttt
     3121 gaccatgcta attgcagtca ccacatctgg cgtaccaacg gtcatcccac gatttaccaa
     3181 gaccatcaaa gcctgaataa cttgacgggc ttcctcacag gcagactctt ctcccaaaac
     3241 ctggacaatc tccgtacgag catgaatcac aacatcaagc tcttcttcca tcaaacgaag
     3301 atggcgttca ttggaaccaa aaagatgaaa caggtcatct ggatgactca gttgaatgtc
     3361 tattgaatgt tccttcaaat aaagaacctc tctaatcctt ttatttcttt ttattatagc
     3421 agagggatgg agaaattact agcccaaacc tagtgaataa atgctagtgt tctaagtatt
     3481 cttgccagat agcgtcaaag tctcctaggt taaaagagaa actggcatgc tcctccaaaa
     3541 agcgactgac ctcatcaaaa tcatctgtgt gttttggaaa agctgcctct tcaaaagcga
     3601 ggtctgccaa aattgctttg ggactgttac ttttaggatt gcgctcggtc atgagccaag
     3661 tgtaaaatga ttttctcata agcctcccta aatcaactct gtcccaaact ggtcctgctt
     3721 gattttacca gccttcataa gaccacctaa agctttcttg aactgacctt tagaaatgcc
     3781 aaaggttgcc ttgatgtcgt ctggagatga cttatcattt aaggtcatga aaccgccatt
     3841 actttccaaa taagtcaaaa tcatctgagc atcgttttcc aacatttcaa aggagcgtgg
     3901 tttgagggag aggttcagag tgcggtccac ttcacggaaa ccaataacgc gcgcatctaa
     3961 tacttgcccc aaacgtggct ctgcgtaacg ctcgctagga tgaataaaac caagcatatt
     4021 attttctggt aggtaaacaa aagttcctga cagcttgaga cggtaaacaa tggctggcca
     4081 gttttggttc tgcatgttgt tgtaggcagg acgagcaaga cgttggaagt cttcttgata
     4141 agccaagagg ccccagatac ggtctttctt atccacttca agacggatgt agagttggtc
     4201 gcccttctta ggccagagtt ccttgagctc agggagaata tcgagtgaca caacgatttc
     4261 cttgtcagga aggcctgtat ccacaaagac acccaagtcc ttacgaacct ctgtgacacg
     4321 tccccaacca aattggtcct gagtggcagt cacttctaag gttgtcaggc ggagtttttg
     4381 cttcatatcc gtgtatgcaa aacctttgac cgtatcccct actgtatgtt ggccttcttc
     4441 cttagcaaga gcataggttt gaccatcctt ttgcacaaag taaaaacggt cgttttcatc
     4501 gatgatcagt ccaacgataa aacttgcaag atttgtattc atatttcctt ctttcgaata
     4561 aaactcagcc agcaatgcca actgagtttt tctgtttatt tttagacttc caaaagttct
     4621 ttctctttgt tagcagtcat gtcgtcgatg tgtttaacag catcgtctgt tactttttga
     4681 atgtcttttt caagagtctt caattcgtct tcagtgattt cttttgcttt ttctcgtttc
     4741 ttagcttcgt ccatagcatc gcgacggata ttgcggacag ccactttagc attttcgccg
     4801 accttcttca cttctttagc aaggtcacga cgagtttctt ctgtaagagc tgggataacc
     4861 aagcgaatca cagaaccgtc attagccggt gtgataccaa gatcagaagc gttcaaggca
     4921 cgttcgatgt ctttcaatga agacttgtca aatggtgtta ccaacaaaac acgcgcttct
     4981 ggaatcgtaa ttgaagcgat ttggttaaga ggagtttcga ctccatagta ttctacatgt
     5041 acacggtcaa gcaagcttgc attggcacga ccagcacgga taccaccaaa ttcacgagca
     5101 agtgattggt gagactgggt cattctctct ttagcttttt caataattgc gttagccata
     5161 ttctttctta ttccttttct tcgatattat ttgaaactgt tgttccgata ttttcaccaa
     5221 atacgacacg tttgatgttt cctggttggt tcatgttgaa gacaaccaag tcaatgtcgt
     5281 tgtccattga gagggttgag gctgttgagt ccatgatacg aagacctttg ttgataacat
     5341 cacggtgggt caattcttca aacttaacgg ctgtcttgtc cttcttagga tcggcattgt
     5401 acacaccatc gacgccattt ttagccatga ggatggcatc tgcttcgatt tcagctgcgc
     5461 gaagagccgc tgttgtatct gtcgagaagt atggtgaacc aattccagca ccaaagataa
     5521 cgatacggcc tttttcaagg tgacgaaggg cacgtccacg gacataaggc tctgccactt
     5581 gttgcatggc aatagctgtt tgtacacgcg tatcaacccc aacttgttgc aatgaatctg
     5641 ccatcacaag agcattcata acagtcccaa gcattccagt gtaatctgcc tgaacacggt
     5701 ccatacctgc ttctgctgca ggttctccac gccagagatt tcctccacca ataacaaggg
     5761 caatttcgat acctaagcta tgaacttctt gaatctcttt tgcgattgtt tgaactgttt
     5821 ggatatcaat ccctacgcca cgttcaccgg caagggcttc acctgataac ttgattaaaa
     5881 tacgtttata cttgggattc gccattttca ctctccttct ttcatcctac ctattttatc
     5941 acaatttcta agatttttat agtatcatga gcaattcttt caaaaaaatt agacagtcaa
     6001 aaattcctct aagtcggcaa gggcacgctc tgcaattttt tcataacgag ccttcttatc
     6061 acggatacgc tcgccttcca actccttgat gatcccaaaa ttgacattca ttggttggaa
     6121 atgtttgctg tcggcatggg taatgtaatg agctaagctt ccaatcgctg tcgtctcggg
     6181 gaaaataacc tcgctttctt ccttgaagag acgagctgcg ttaattcccg caactaagcc
     6241 cgaagccgcc gactcaacat agccttccac ccccgtcatc tgaccagcaa agaagagatt
     6301 tggttgtttc ttagaacggt aagtctgctc aagaagattt ggtgaatcca tgtaagaatt
     6361 gcgatgcatc acaccataac ggacaaactc cgcattttca agacccggaa tcatttggaa
     6421 gacacgcttt tgttctcccc atttgaggtg ggtctggaaa ccaacaatat tgtagaggct
     6481 accagctgca ttatcctgac gaagttgcac aaccgcataa ggtgttttaa attctccatc
     6541 acgaggtcct gtatagtcgt ctgggtactc aagaccgact ggcttcatag ggccataaag
     6601 catagtttta atgccacgtt tggccatgac ttcgataggc atacatcctt caaagtactt
     6661 ttctttttca aaagaattaa gcggtgcttc ttctgcattg accaaagctt catggaaatc
     6721 cataaattct tgcttggtca taggggcatt gaggtaggcc gcttctccct tatcataacg
     6781 tgatttgagg tagaccttgc tcatatcgat agtgttgaca tcgataatag gcgctgccgc
     6841 atcgtagaaa taaaaaccag caccgtcatt aagagcatga atcttttcag ctaaggcatc
     6901 acttgtcaaa ggaccagtag cgataaccgt aataacatct gtcggcaatt ctgtaatttc
     6961 atcacgaacc acttcaatca aggggtggtt ggcaactttt tcggtcacca tttgagagaa
     7021 accatcacgg tccactgcaa gggcaccacc tgcaggaaca cgtgtagcct cagcagattc
     7081 caagataaca gaacccaagc gacgcatttc ttccttgaga agaccaactg catttgtcaa
     7141 agcatcccca cgcaaagaat tggaacaaac caactcagca aaattgtctg ttttatgctg
     7201 gggtgtagac ttgacaccac gcatttcata tagtttaact ggaataccac gctctgcgat
     7261 ttggtaagct gcttcagaac ctgccaaacc agcaccgata acattgatat aagattgaga
     7321 cacgacacta atacctcttt gggagtgtga agttaagatt cacattgaaa aagccaatca
     7381 gacttacgag ctttcgagtt tcttggctca ggctgaaaaa gtccacagga ctttttcact
     7441 cccacaaatc tttctatttt ttcttctact agtataacaa aaaaagggaa gaaggcaaac
     7501 ttccctgttt agtcattttc ttgatgtaaa gagatagtga gtattccagt taagaatcaa
     7561 ttatatgcta ctctataaaa tcttttccac ataacggatc gatagggact gttattctat
     7621 ctcttgctat aaccgtatta tctaaaacag cataacattc aacatagtga tctcctttaa
     7681 actgtgaatc ttcgtgatat tttattttta cctgaaaaaa tagcaccacg ctcacaattt
     7741 cttctaatag cctcagcttc aatatttctt actttccaat agacttcctg cgaaacaaaa
     7801 tatggtatag tagttctatg aatgatgaag caagtaaaca actaactgat gcacgattta
     7861 agcgtcttgt tggtgttcag cgtaccactt ttgaagagat gttagctgta ttaaaaacag
     7921 cttatcaact taaacacgca aaaggtggac gaaaacctaa attaagccta gaagaccttc
     7981 ttatggccac tcttcactat gtgcgagaat atcgaactta tgaagaaatt gcggctgatt
     8041 ttggtatcca cgaaagcaac ttactccgtc ggagccaatg ggttgaagta actcttgttc
     8101 aaagtggttt tacgatttca agaactcctc tcagttctga ggacacggta atgattgatg
     8161 cgacgaaagt aaaaatcaat cgccctaaaa aaagaattag cgaatgattc tggtaaaaag
     8221 aaatgccacg ctatgaagtc tcaggcgatt gtcacaagtc aagggagaat tgtttctttg
     8281 gatatcactg tgaactattg tcatgatatg aagttgttca aaatgagtcg cagaaatatc
     8341 ggacaagctg gtaaaatctt ggctgacagt ggttatcaag ggctcatgaa gatatatcct
     8401 caagcacaaa ctccacgtaa atccagcaaa ctcaagccgc taatagctga agataaagcc
     8461 tataaccatg cgctatctaa ggagagaagc aaggttgaga acatctttgc caaagtaaaa
     8521 acgtttaaaa tgttttcaac aacctatcga aatcatcgta aacgcttcgg attacgaatg
     8581 aatttgagtg ctggtattat caatcatgaa ctaggattct agttttgcag gaagtctaat
     8641 gtaattctca agctgtgagt tcattatgat ttgtaaatcc gatatatctt cagcagctaa
     8701 aaacacattt tgaaatgttc caagtccgtt ttcaccaaaa ctatattctc tcttactata
     8761 cttactctta ttattctcta tatagttaga gtcaaggttc ttaacctctt gaagttcatt
     8821 ttctttactt ctgaggttaa aatcttttac ttctgaagtt aagttttttg acttctgtaa
     8881 gtcattttct tttacctgaa atatactcat aaagtcttta acataaatga tattcggctt
     8941 accaagtcca agccttactc tttcgatcag tcctattcct ttttttacat caagctcatc
     9001 taatgttttt atggcagttg gctttgagat atttcttctt ttcataattt cttcgacagt
     9061 aaaatagata aatactctgc cttccttgtc tatccagtta ttcttaaatg acattcctgt
     9121 ctgtttaaga agtatggaat aaaggataat tgcttctgct gataagcccc gaaattcttc
     9181 tctatcaact aatatctccg gtacttttaa gaagttaaat ctttccgctt ctctgttata
     9241 aaaatattca aagtccatgc aagatcacct cccttcttaa aaatttgcaa agaaaaagac
     9301 gatagttttt cttctatcgc ctttggtaac catttttatg aaatttttta aagttaaaaa
     9361 tataatttat aatactatct tcttccattt tctgatttta gttctgaaag ttccaaaagg
     9421 tgcaaccgta tttacatgaa taaacttata cacttcccaa gtcgctgttt tagtcgcttc
     9481 atcagcccac tttctcatat gcggttcaaa taattcttcc tcactcaacg aatcaatcat
     9541 tgcagagata gaattaatat tttcatttaa ttttgctttc aactcttgca gagataaatg
     9601 agcgtaggta tctgtgaacc actgatataa ctcaccaagt tgattccatt taaatttatc
     9661 cgatggtgtt tttacttgaa gcccctttct ttcatcttct tcccatttaa gaaccaagtt
     9721 ggtccaacca acctgataag caaggttttc tgctggagtt ctgtcaactt catcagctct
     9781 cttatctttt aaattttctg gaatattatc aaattctaaa atatatttct caaatgtttt
     9841 ctctatctca gcttttagtt cttctttatt ttcgtatgtt cgcaaaaaat caccttcttt
     9901 ctgatttatc aatcctttga tttaaaatga ccttattttt ctatttatac cttctaagaa
     9961 cgctataact gctgctccaa ccatcggtat tccgtatggg cttaataaaa aacttaatac
    10021 caaagcttct ataccaagtg atacatcttt atattatcat cactaattaa gttaaacaga
    10081 aacagacaga attattacat cctgtctccc tttattgttt ttcttcccag tcgtggtagg
    10141 cagcgtagag ttgactctta ttccactggt aaatcttagc tacttcctta atagcttgat
    10201 ttttcttcat accttgctgg atacgagctt ggatttctaa gaacaagtct tcctcgtctt
    10261 tttcttccac acctttgctg gcaccttcaa caatcagaag acattcaccc ttgagagacg
    10321 tttcagagat gctttccagc aattcagaaa ttgtacctct ttggtattct tcatagattt
    10381 tggtcaattc cctgaccaag acaacggagc ggtcaccgta gacttctaac atattttcca
    10441 acgtgtctgc tacacgatga ggtgattcat aaaaaatctg tgtttcagga taatcttttt
    10501 tcgagtcaaa aaattgcttc tgctggcctg attttctcgg taaaaagccg taaaagatat
    10561 gtggctgcgg cgctaaacca ctggcaatca aggcagaaat tcctgcagag gcacctggaa
    10621 ctgtaacaac tgcaatttct tcctcaatag ctgccttaac taaatcatga ccagggtctg
    10681 aaatgctagg caaaccggca tcagagacct gagcaatact ttgccctgct ttcaagaaac
    10741 caatcaaatc aggaattttt tccttggcat tgtgctcatg aaaactgatc tgcttggtgg
    10801 aaatgtcaaa atgcttgagc aaaagccctg tattgcgcgt atcctcagca gcaatccaat
    10861 ctacttcttt caaggtctgg atagcacgaa aagtcatatc atctagattg ccaatcggcg
    10921 ttgccactag atacagcttg ccatagggag actgcccctt aaaacttttt tgaatttgca
    10981 tgcctactcc ctgtataaca actcatcaca gaacatacat tcttcgtcct gctctcgacg
    11041 ttgtccataa aaatcattac atacgtgaaa tccatcacgg taaatacgac ggacactttc
    11101 gcgaacatgc ttggccttga cgggagcgtc tgcttccacc tcacccaagc gttctcgcaa
    11161 cttactattt tccaagcgaa gagctgtatt ttcttctacc aagctcttga gatttttctt
    11221 gatggcttcc acatcggcta aggttaccaa taattgttgg gaaaaatcat ccagcgcgtc
    11281 aaataattct tttttgtcca taaaacagcc ctttcctttc tttatcattc atttttgagt
    11341 ttatatttct ttcaagacca gatattccat ggcattttga aagctgacat tagcttgcca
    11401 catttttcta gcttctagta aatcttgtag aatcactctt actcttacct gcaagaggtc
    11461 ctgcccacag agaacttcaa gaatccgtaa aacctgatcc tgtttttcct tatcatctgc
    11521 caagttggct aatttggcaa cctgtagata actttctttt ttcttagcta ctaaccaagt
    11581 cagcaggcgt tcactttcat cgaccaaggt ccaaaaactt gcctgattag ccaacttttc
    11641 tgcttcagct cgcgattgac taaacttagt taaaagagtc gcttttttct taacaagtcc
    11701 catttgttct aagagtaaga tgagtttttc ttcttgcttt ttaaagtgga agatctgagt
    11761 ccgacttcgg attgtcggta acatcttttc ctcatcgcta gtcaagaaga aaatataaac
    11821 ttcactctgg ggttcttcga tgaccttgag cagagaattg gctgcgttgg gatgcatttt
    11881 atccgcttgc tcgatgataa agacctgttg ctggctttca atccctgctt gagaaaactg
    11941 tcccaccaat tcccgaatgc gttctgtctt gatgacctga ttgactggct taatcaaggt
    12001 gacatctgga aactcttcct gttcaatcag cttgcaactt cggcatttct cacatggtaa
    12061 gacgccaact ttatccgtac aaaagaggct cttagctaaa aattgcgcca tttccaagct
    12121 tccaaagaaa cctgaaaaga gataggcgtg attgagctgg tcttgttcta agatacggac
    12181 aaaacggtca aactgagctg gttgccaagc ctttagttga tcttgtttca tttggccaag
    12241 cccattccgt caaacaagac agccttggta gtttccacaa cttgctccaa agggagacta
    12301 gcatcaatct tgacaatgcg atttccttct ttttccagga gagaaaggta gccttgacga
    12361 acttttttat gcaagtccaa cccttccaaa tccaaacgat taacctcgcg gtcactatta
    12421 gcagcaatac gagccagccc ttcttccacc tcgatgtcaa aatagagtgt caaatcgggt
    12481 ttgaggccat ctgtcgcaaa ctgattgagc cagtcaatgg cttcaatatc taagccacga
    12541 ccaaatccct gataggcaac agaactatcg ataaaacgat ccatgatgac caacttgcca
    12601 gcttcaaggg ctggaagaac tttttccacc aaatgctgtc tgcgactggc aatatagaga
    12661 agtagctctg ttttagcatc catctgagta tgacttggat ccaaaatcac ttcccgaatc
    12721 ttctccccaa tcaagactcc gccaggttca cgggtcgtca gcacctttac tcctttttcc
    12781 tctaaaattg gtagcagagc ctctaaaaca ctggtcttgc ctgctccctc tggtccctca
    12841 agagagacta aaaatccttt tgacatgtct aactcatttc ttttttacta cttctattct
    12901 atcaaaaaaa taggggtttg tgacaatctt tttgtgtctt ctcatttcat actcaatgaa
    12961 aatcaaagag caaactagga agctagccgc aggctgtact tgagtacggc aaggtgaagc
    13021 tgacgcagtt tgaatttgat tttcgaagag tatcaaccac cataaaagag gcagataaaa
    13081 ctacctctta tttacctagt tcttgtgttc gtttgtaggc ttgatgaact gcatccatga
    13141 ctgttcctcg gaaagcatgc gcttctaggc ttgctacacc agcgatagtc gaaccgcctg
    13201 ggctacagac ttggtctttc aatactccag gatgttgctg gctttctagg accaattgcc
    13261 cagctcctac cacagtttgg gctgccattt tcaaggctgt ttctcgtggt aatcccgtct
    13321 gaacacctgc atctgccaag gcctcaataa agagatagac aaaggctggt ccacaacctg
    13381 caagacctgt cgctgcattg attaagcttt ctcctaattc aaccaagaga ccagccttgg
    13441 ctaaaagctg acaaaagagc tcactgtcct cagccctgca attaggagac aaggcataac
    13501 taatcactcc ttgcccgata gaagcagggg tattaggcat catacgaata attcggtgtt
    13561 ggcttgggat aagacttgct agtttttcta aggtcaatcc agctgccatc gaaatcaaaa
    13621 gaagactttc tcttttttca aggatggtct ggtattgaga aagcagttca gaaaactgag
    13681 caggcttaac acctagaaaa atcacatctg cttcttcgaa tatttcttca ttgttagaag
    13741 tctgaccacc gaagttagcg atgaaagcat ccaccttgac ttgactacga ttggcaagga
    13801 gaatctcatc tgacggtcta gcctgcaaga cagacttggc taaactagca cccatattcc
    13861 ccaaaccgat aaatccaatc ttcatccctt actcccttat ctgtccatca ccagtgacca
    13921 catacttgta gctagtcaat tccttcaagc ccatgggacc acgcgcgtgc aatttctgag
    13981 tagaaatccc catttcacaa ccaagaccaa attgtcctcc atctgtgaaa cgagttgagg
    14041 cattaacata caccgctgca gagtccactt gatctgtaaa gtatgctgca gcttcagcat
    14101 tttccgtcac aatagcatcc gaatgatggg tgctgtggga ttcaatgtgc gcaaccgctt
    14161 cttctaaact gctcacaacc ttaacagcaa ggacatagtc taaaaactcg gtgtcaaagt
    14221 cttgggtctc agctgcttga cctgaaacaa actggcttgc tttgctatcc aagcggaatt
    14281 gaattggttc cagtccagct tccttacgct ctgcaaccag catttgatcc aagcgaggaa
    14341 ggatgcttgc tgccttgttt tcatgaacca gcagaacctc catggcatta caaacagaag
    14401 gacgactggt tttagcattg ttgatgatag acagcgcctt gtcttcgtct gcatccttat
    14461 ccacatagac atggacaatc ccagtccctg tctcgataac aggtacaatc gcattctcaa
    14521 ccactgcatt gatcaagcca gctcctccac gaggaatgag aaggtctaga tagcccttgg
    14581 ccttcatcat agcataacta ctttcacggc tagtatcctc caccagttga atcacatttg
    14641 gatgaatagt agtcgtctcc aagcccttct tcaaggctgt gacaatggca tgggttgttt
    14701 gataggcatc cttaccacta cgaagaacaa ccgcatttcc actcttaaga gtcaaagcag
    14761 ccgcatcaga cgtcacattt ggacggcttt catagataat accgatgaca cccatagcta
    14821 cacgtttttt tgtgataacc aaaccatttt caagctgact tgtttctaaa acttcaccga
    14881 ttggatctgg taaggcaacc acttcacgaa ttcctcttgc catcgcttct atacgatctg
    14941 catccaaata aagacgatcc aacatcacat ctgagatttt ccccttagcc gctgccatat
    15001 cgagggcatt agccgctaaa atttcctcag tagcagccac taagtgatca gccatggcta
    15061 gcaaggcttg gtttttcact tcttcactag ctgtgttaat cgatttttta acagcctgta
    15121 cctgttcaaa ttgttcttgt ctactcacca tagtttacct ctaaaattct gtaaaaagta
    15181 gttggatttc aggagtaatg gaaatccagt cgtcacggta aatcaagaca cccttggctt
    15241 tttgagaacg caacatatcc tccaaagcag atgctccaaa ttgcacgcgt ccttttccaa
    15301 gtgattttcc actttcctta tcaaatactg tcacgatatc accgtaagaa aagactcctt
    15361 ctgcttcaac gataccagat aagagaagac tctttccatg ttgagagaga gcttccgcag
    15421 cccctttatc aacccaaata gaaccttgac tctgagcata gaaggcaagc cattgtttct
    15481 gggtacgaag ccccttctct tgagcaacaa agtaagaacc atcctcggtc tcctctgccg
    15541 cctcaatcat ggaatctgat ttcaaggatg agcagatata aacaggaact cctgattccg
    15601 tcgcgatagt tgcagccttg attttggtta acataccccc agttccgttt gacgaaccag
    15661 ctccaccagc catatcaata atctcacgat tgatggtctc gattctctcc aagcgtttgg
    15721 ctcttggatc tgaattagga tttccagtat agagaccgtc cacatctgtc aagaaaacta
    15781 aaaggtctgc ttggaccatc gccgctactt gagcacttag agtgtcattg tccccaacct
    15841 tgagctcatc aataacgaca ctatcattct cattgatgat aggaattgcc ccacggttga
    15901 gcaaaaccga caaagcctga tgggcatttt tataacgacg cttatccaca aagtcatctt
    15961 gggtcagcaa gatttgtgca gaaacgattt gacgcaagag aagattggtt gtatattctt
    16021 ccaacaaaag cccctgccct accgctgctg aagcctgttt atcagcaatt ttagtcggac
    16081 gctttttaaa tcctaaggct ccaaaaccag ccgcaatggc acctgaagac accaaaatca
    16141 actcatgacc agcctcgtgc agcatagcca actgctgggt aatatccttt accttactac
    16201 gtgataaact tccatcctca tttgtcagag aagaagtacc caccttaaag acaatccgtt
    16261 tgtatttcat agtctcactc cgattattca tatttatcca ttataacatg aataacagga
    16321 aatagaaaag agttgatagg aaaaagaagg ccctaaaacc ttcttttcta ctactgttct
    16381 gattccgatt tgtttacact cgtttcagag ctttgtgaag ttgaggatgt caaatcttga
    16441 ctagttgaag aatttgtaac actttcatgt tgactcgttt ctttattttc aagatccttt
    16501 ttcactactt ctttggattc ttttatttct gaatgacttg tagttttaat tgtagcagat
    16561 ttctcgatcg gaacatccac taaccaggca ccacttgaat ccacagtata gccttctggt
    16621 gtcttaccat tcacaagtaa ttgaccattt tctttcaaga agtaccattt atccttgtct
    16681 ttaatccaac ctatagctcg tgaaccatct gtcttgtaga aataccaatc atttgccttt
    16741 ttaagccagc cttgcttcat agctcctgat tcttctagat agtaatgatg tccagcaact
    16801 tctatctcac ctgtcttcat gataccagta gaatccatat agtaccaggc ttctttatct
    16861 tttacccagc ccgttttcat ttcccctgat ggagcaaagt aataccattg ccccttatat
    16921 tgaagccaac ctgtcttcat agagccatca acatccaaat aataccactg ctctttatct
    16981 tgaatccaac caatttccat ctggttttct ttgttaaaat aataccagat tccagcgatt
    17041 ttcttccaat ttttagcagc aacaccagag tctgtcaaat agaaccaacg attgttccat
    17101 tttttccatt gattctgtaa taagataccc gtttggttaa agtaatacca ttcaccctta
    17161 atttcattcc aaccaacagc atattctcct gtagaatcag gcgcttgata ccaccagttt
    17221 ccatatgaac tcttatgcca accagcttga aaacttggaa tcggcttgta ggaagttgaa
    17281 atgtttacta aaccgtcttg tcgaatatca aaaactgttg catcatagtc tttgctggct
    17341 gcgttgattc tctcaattcc tcgttctttg agccaattaa catactcact atcaacacca
    17401 tttttccaag gtagactatc cgaagtttga acaatcaaac tcggactcaa atttttaatg
    17461 aaatccttgg tatttgattt gttggtatca tggtgatgat taaacttcat caaatcaact
    17521 tttccaatga gaggaccata cttgtcttct gctccatgaa cattatctaa atcgccccca
    17581 aggtaaattt tcttgccatt gactttcacc acgctaatca aggaattgga attgtcatcc
    17641 caaattttct ttaattcacc cgatgaatca gtttcatttt cataattata gagctgaata
    17701 tccatgtccc caaactgaaa atgagcatcc ccttgtgtga tattttgaat aactgaaaca
    17761 cctttttctg cagcagtctg taaaacctta tcatagccat acagattatc ccatagacgt
    17821 tcagaattag taatacgact atcactatat ttcttaagat agactcggtc aactggatag
    17881 gtagacagta attcatcaac atttccaata tgatcactgt gggtatgggt caccaaaata
    17941 aaatcaagtt tttggacacc caattccttc aaacgacgaa agacacggtc tgtcagaaca
    18001 tgcttataag tggtattaat accctgtctc catggatagc gagaatcact tccatctggg
    18061 aaatcataat cttctcctgt atccaccatg gcaaaatgtc cattgctttc aagaataatc
    18121 gcatcactgc caccttcttg aacattgata aagtggattt tatttcctga actttcttga
    18181 gcctgaacat tcccatacca tgacaaacct aaaaaagcgc ctacaagtgc taaactagtt
    18241 aatttctttt tcattcttac tttctcaatc tctccaaggt ttccttaaaa atctctggga
    18301 tatctgcttt aaattccaag gtcttacctg ttctcggatg agtaaaacct aaagtcttgg
    18361 catgaagaaa ttgtccatgt cctttcaaag tcttgcgagg accatagacc tcatcaccag
    18421 cgactggatg gccgatataa gccatgtgga cacggatttg atgagtacgc cctgtctcca
    18481 gttgcaactc tactaagcta taatcgccaa agcgttccaa gacgtgaaaa cgcgtcactg
    18541 caggcttccc tttagcagtt acagcctgtt tcttacggtc tttttcactc cggccaatcg
    18601 gcgcttcaat tacaccacga tcattaggca gatttccatg aacaatcgcc caatatttgc
    18661 ggagagactt tttatccttg agttcttggg caagtgctag atgcgcatca tcgtttttag
    18721 caatcatgag aagacctgac gtatccttat caatacggtg aacaatccct ggacgcagaa
    18781 ccccattgat acccgacaag tccttaatat gatacatgag ggcatttact agggttccac
    18841 tggtatgacc agcactcggg tgcacaacca ttccctgagg tttgttaacg acagccacat
    18901 cctcatcttg gtagactatt tctagcggaa gatcctcagc cacatactct aatacctctg
    18961 gttctggcac atggtaagtg acgacatcac cctcttggac tgtgtattta gctttcttga
    19021 cttgaccatt gaccaagacc tggcctgatt taatttgttc attcgcgaga ctacgtgata
    19081 attctgacaa atctgacaaa gccttatcca aacgcagacc accagtttca attttaattt
    19141 ccatttattt cctcttttag cattgcaatc aataaaataa tcactccaac cgtcagatag
    19201 ctatctgcca cattgaaaat tgcaaagttg ataaagtcaa ggtggaacat atccacaaca
    19261 aagccctgac tgaccctgtc aataaagttt ccaagaccac ccgcgattat tagagtcaaa
    19321 cccaagacca tccagaatga gtcctccatg tgtttatgta aataccaaat ggcacctatc
    19381 acgacaacca gagtaatgac agcgaataac aactgctgat cttgtaagat agaaaaggct
    19441 gcacctcgat tttgcaggta ggtcaagcta acgaaattgg ggatccagga gcgcacttca
    19501 cccagtggaa tctgctggac gatataggat ttgaccaact gatccagccc aattaaaagc
    19561 agtacaatga ctgccactat tgctcttttt ttcatgattt cctcttttga tcaaaatatt
    19621 cttgcatgac ttctacgaag agagtcccag cttgactaag ctccacttct tcacgtttaa
    19681 catagaccat gcggttatct aggttatcct tgagacgaat aactgtaatg ccattaacac
    19741 tgtcactatc taaaaatcca gaacctgtcg cataggcgtc cgtccgctcc aaaataccat
    19801 tcaaggtggc acggtctgtc acattaaaca tctgtgagct agcgctggta tcgacaaagt
    19861 tctctgaata ataaaggtac tcgtctttct cttgagtgaa acgaaccgtt ggtaaatccg
    19921 ctaaatcctc catgactaat tcatctttct gggctaaagg atgaccctca cggagataaa
    19981 tatgggtatg gaaaggaatc aattcgatga cctccagacc taatttttca acccgttgca
    20041 taatcccctt tttattttga ttgttgaggt agataatccc aatctcacta tgcccttgcg
    20101 ccacttcatc taatatttga acagtagttg attcaaaaat acggaagttc ttatagtcag
    20161 gatagcgctc tgaaaaggcc gtaatagttg gtggtaagaa gtcatagtgc tggctagcaa
    20221 cggaaaattc atctttttct tcttcaggat tggcatactg attttgaaaa atatcaaatc
    20281 ctttaaccaa ttcttgcgct ttttcataaa attccatccc acgacgggtc aagaaagtcc
    20341 ctgagctggt ccgacggaaa atcttaaaac ccaactcttt ttccaaatcc cgaacagaaa
    20401 tagacagact cggctgacta acatacatct tttcagcagc ttcacgaaaa gtaccactat
    20461 tggcaatagc cacaacatag cgtaattgtt gaatgttcat cttctacccc taacttcttt
    20521 atcttttcat tataccatat tttagaagtt ttccaaaaag gaaaaaagaa catcctattc
    20581 ttcttaacta tcttcactat ctgcctttct caagccaacc ttattttcaa aatcaattca
    20641 aaaaaataac tggctacaca ccactacaat atcgaaaaga aaaacgttga ctatttgtga
    20701 aaaaagaaaa tgccggaaag ttccgacatt attttagtaa gctaacttcc tgaaaatagg
    20761 agcaaccaca catcccagaa ggcagtgata ttaatgagaa tatgaactag tattggatag
    20821 tagagatttt tagtcatgcg atacaataga gctaaaataa gacctccact agcataaatg
    20881 aaaaaagcaa gaggagttaa agcaaaattg atatgaatat aaccgaaaat aatagcagaa
    20941 agcaaaacat ctccgtacca aggcgagttt ttgaaaaagg ttgtcataat cacaccgcga
    21001 taaatcaatt cctcagcaat aggggcgatg aagcaaacga tgagcaagaa ataagggaac
    21061 tcctgtcgtc ccatcatttc tatcgtttca ttcaaagaaa tttgatttga aggcggggat
    21121 atgaaatacg aaaagaggaa gtcagacata tatgaaatga tgtagcccag taaaaggtag
    21181 atgaagtacc tcagctgcca cttgaaatga aaaattttct ttcctgcaaa aaccagtaga
    21241 tagatgaccg ctaagaaaag aactccactc tccatcaaaa gaagaatctg aaaaaattca
    21301 cgacttgctg gtagataggg ctttgcgaga taattgaaaa gcctccaaaa ccaagttgat
    21361 ttgtaaaaaa ttaaggacaa tactagtaaa atttgaatag ctcgtttttt catattaaat
    21421 cctctgtttt ctccccttgt ttcttcatat tcctaataaa ttttacttaa aatctcgcag
    21481 cacttccttt gcaaagatga ttacctcctc caatatatcc taaatcatcg gttcctctgg
    21541 gacaaaatcc atgaaccagc agagttaata ctggttctat ttcccaatcg tacctaccat
    21601 taggattttt accatatgga tctgctccac cttgtatcag ctctaattct tcatttgtta
    21661 gatttatatt ttttgtcatt aaaatcatga tatatttcct ccattattct tcagattagt
    21721 tgagtaatct gctactcata cctacttaca aaaaaactat tatattaagt tggtttttta
    21781 atttgtctag ttgcaacatt gacaaacata gtatagcata tctttgcgaa atatcctctt
    21841 caaatcatga attgtcatca aaacatctta aactataaaa tcaattagtc tcaagctttc
    21901 tatcaatttc ttctccaaaa tatgctataa taatagcaaa agataaagaa ggaagaccta
    21961 tgattaaact actagccttg gatatggacg gcaccctcct caatgaagcc aaggaaatcc
    22021 cacaagctca cattactgct attcacaaag ccattgaaaa aggtgtcaaa ctggttctct
    22081 gtacgggtcg cccccttttc ggtgtcctcc cctactacaa aaaactggag cttgacctcc
    22141 agaacgaata tattattgtt aacaacggtt gttcaactca ccagactagc gactggggct
    22201 tggttgactg gcaagaactg agtccagctg acatcgaata cctctatgac cttgctgaaa
    22261 agagtgatgt tcagttgaca ctttttgacg agtcacatta ttttgttctc ggtggcaaac
    22321 ccaatcaagt tattgaaaat gatgctaaac tagtattttc agacctgact gaaatttctc
    22381 ttgaagaagc gactagtgga aagttccgga tgttccaagg tatgttttta ggaacaaaag
    22441 aacaaacaga cgattttgag cagcgttttg ctgaagagct ttgccaacga ttcagtggag
    22501 ttcgttcgca gcctgtcatt tatgaagcaa tgccgcttgg aacgacaaag gctactgctc
    22561 tttcacgact agctgagatt ttgaagattg attcctcaga gattatggcc atgggcgatg
    22621 ctaataacga tatcgaaatg ctccagtttg cagggcttgg gattgcaatg ggaaatgcca
    22681 gcgattatgt caaatctctt gcggatgccg ttacatcaag caacgaagaa gacggcgttg
    22741 cgcgtgctat tgagaaatat attctataaa aaagaaaagc aaatagacag aagttactgc
    22801 tatttgcttt tttgctaata ttttaaaata cggactaatc aatagacaag aatagcgaat
    22861 cataaaaatc gatttactag atgccatagt atcttatagt tgctaataag aagttagtct
    22921 agcagaatga atctctcatt tctcccacac taatctgtaa tttgtctata catttctggt
    22981 cttctatctc gaaacaagcc ccagtttagg cgttcacttg ctcccttgtc taagtcataa
    23041 gtagctaaca gaacagcttc ttcttgtctt tcagctcgtt ctagaatagc tcctgtttca
    23101 tccgtcataa aggaggaacc gtagaagtca agactggaac tctgtccgcc attttcctca
    23161 ctaggagtaa cctcctctaa accataacga ttggctgcga tgactggaac aatattcgct
    23221 gctgcgtgcc cttgcatagt acgttgccag tgaccacaac tatctgtatc caaaattggc
    23281 tctgaaccga tagctgtagg ataaaagagc aattcagcac cattcaatgc aagacagcgc
    23341 gctgtttcag ggaaccattg atcccaacag ataccgatac caatcttagc atagcgagta
    23401 ttccagacct tgaaaccagt gttaccaggc gtgaaataga atttttcttg ataataatgg
    23461 tcatctggta tatgggtctt tcgataaacg cccagcactt ccccatctgc atcaatgacg
    23521 gcaatagagt tatacaagac attaccatct ttttcataga aactgattgg taaaacaact
    23581 tgtagttcct tagcaatcac cttaaaatgc tgaatggcag tattttccgc tacagattgg
    23641 gcatactggt agtagtcata ctgacgttcc tgacagaaat agggatgttc aaacaactcg
    23701 ggcaagagaa taatttgggc tccttgctca gcagcctgac gtactaaacg ctctgcggtt
    23761 tggatatttg ttgccacatc cttagcgcat tgcatctgaa tggttgcaac tcttacattt
    23821 ctcatctttt tctcctattc tggaatttgt tgggtgatac agtggatatt gccaccacct
    23881 aagagaatat ctctggctgg tattccgaca actttacggt ctgggaaaca cttgctgagg
    23941 atatctaagg ccacttggtc gtttacatcc tcaaactgtg gaaccaagac agccttgttg
    24001 gcgatataaa agtttacgta ggaagctgct agtcgttcac ctgcgtatcg cttttcttct
    24061 ccttcttcat agatgtagcc tggcaaatct tcttctgtca caacttgtcg aactgcaggg
    24121 ataggcaatt tatgaatggt gaagtgacaa ccttttgcat ctgtttcctg ttctaagagt
    24181 tcgagatctg cttttgacat ggcatactgg ggatcatttt cgtcatctgt ccaagccaaa
    24241 acaagctcag caggaccaac aaaggcagca acattatcga cgtgttcatt ggtttcatcc
    24301 tgataaatac cataaggaag ccaaataact ttttcagcac caagactttc taataatgtg
    24361 ttttcaatct cctctttagt caggttagga ttgcgaccag gactaagcaa gcaactttca
    24421 gttacgagaa tagttccttg accatcgcta tggattgcgc ctccttccag tacaaaaggt
    24481 ttagcatcat agacaggcct ttccaaggcc tcagcaaaac gactggctac ttggtcatcc
    24541 tcttcataat cttgataaag accatcatag gtgcctcccc aagcattgaa ggcccaatcc
    24601 acggctaatt tcttaccttt atcattgacg agaatggttg ggccagtatc acgcgcccag
    24661 gcatcattgg tgggaatgtc taaataaaca accttgtctc caagatagga ttgggcttca
    24721 gatagatagg cctgctccac caaaagatag actctttccc cttctgctat ggtctcgatg
    24781 atctgagtaa atgctctttt agcagccttt ccttgaaaag gccatgatcc tggtcgagtc
    24841 ggccatatca tgagggtacc atgatggggt tcgtactctg ctggcatgtg atagcctaat
    24901 ttttttggac tgtccatcat gataatctcc ctttaaagtc ttgatagcca aaagctttga
    24961 gtaagctaca gtctccctgt tcgtccatga gatagagact tggcaatcca ataccattaa
    25021 aggtattatt tttgacaaaa gaataaatgg ccatgtcttg aaaataaagt ctgtctccga
    25081 tttggactgg attttcaaaa ctataatcac caatcacatc gcccgtcaga caggtattag
    25141 aagaaagtct gtaggtatgg gctttttcct gtgcctcaaa gccatttctc aaaggtggac
    25201 gatagggcat ctcaagtaca tcaggcatat ggcaggtcgc agaggcgtct aaaaccaaga
    25261 tttccatacc gttttctaca atatctaata cctcagttgc taaataaccc gcattaagcg
    25321 caatggcttc accaggctcg atatagattt caagattgta agtttttcgg atacgcttga
    25381 tttctgaaat cagcaaatcc acatcgtaac cttctcttgt aatatgatga ccaccaccca
    25441 tattgagcca ttttacctca tgtaagtagg gaccaaactg ttcttctact tctttcaaag
    25501 ttgtttgtaa atcatctgct ccctgctcgc aaagggtatg aaaatgaagt ccgtcaacca
    25561 aatctagcaa atcactcgga atcttgtcta tagtaactcc aaagcgagaa cctggtgcac
    25621 aagggtcata gagcgcgtga tctccttgag ttgaacactg agggttgagg cgcaaaccaa
    25681 cactgacacc agcctctcga caacgcgaac catgcttacg caactgtctc tctgagttaa
    25741 agacgatatg gtctgttatc ccaagcaatt cctccatgtc ctcatccttg aaagctggtg
    25801 caaaaacatg gacttcacca ggaaattctt cccttgccaa tttggcctca tagagtccac
    25861 tagctgtcgt acctgataga tactggctaa tcaagggata agttttgtag agggaatatg
    25921 ccttctgggc aagcaagacc ttgcaaccgg cctcttcttg tacatattgt agaatgcggc
    25981 aattagcttc taacttggcc aagtcaataa cataggctgg tgttggtact tgttctaact
    26041 tcattagtcc accatttgtg gattttcaac cacaacccat ggcaaaccat actcattcaa
    26101 agcttccatg aatggatctg gatctaactc ctcaaggtta tacactccag cttgtttcca
    26161 agttccgttc atgactaatt ttgtcccaat catggctgga actcctgtcg tataagaaat
    26221 agcttgcgaa ccaacctctg catagcactc ttgatggtcg cagacattgt agatatagat
    26281 agtctttttg acaccgtctt tgacacctgt aaagatacat ccaatattgg ttttacctac
    26341 agtacgtggg ccaaggctag caggatctgg aagcaaggct ttcaaaaatt gaattggaac
    26401 aatttcttgg ccgttaaagt taatggtatc cgtacgaagg agtccaacat tttcaagaca
    26461 tttcatgtgc gtcaagtaag attgaccaaa agtcataaag aaacgaatgc gtttgacacc
    26521 tggaatgttc ttggccaatg attcgatttc ttcatggtga aggagataca tatctttttg
    26581 tccaacttga gggaaatcat actcacgctt gatagacata gcttcgactt cgacccattt
    26641 cccatcttcc cagtaagaac ctggcgcaga aacctcacgg agattaattt ctggattaaa
    26701 gttggttgca aatggataac cgtggtcacc gccattacag tctaaaatgt cgatataatg
    26761 gatttcatca aaatagtgtt tgagggcata agctgaaaag acactagtta cacctgggtc
    26821 aaaaccagaa ccaagaagag cagtcaagcc tgcttctttg aatttctctt gataagccca
    26881 ctgccatgag tagtcaaagt aggctgtaaa accaagttcc ttacaacgtt tttcgtagat
    26941 agcacgccac tcagggtctt ctgtgtcttc tgcttcgtag ttggctgtat cgatatagtg
    27001 aacacctgtt gccaaacaag catccataat ggttaaatct tgataaggca gagctacatt
    27061 caaaacagct tctggtttgt agctttcaat caaggtaatg acctcttcta ccttgtcagc
    27121 atcaagtgct gcagtttcaa ttttagtact tgttttgcct tctagcttcg ctttcaagtc
    27181 atcgcatttt gacttggtac ggctagcaat cataatctct gtaaatgttt cgctatcttg
    27241 acaaattttt gaaatagcaa cttgggcaac gcccccacaa ccaataacta gtaaacgact
    27301 catttttttc cttcctcttc ttctaaaatg tcctcaacat acttgggcaa cataaaggct
    27361 cccacgtgta agtttgcagt gtagtattct gtgaaaagct ggcgtttttt ccaaccttcc
    27421 ttgtcaaaat ctttgacagg gtggtatttt ttcgatgcaa atccaaacaa ccaatagcca
    27481 gctgggctag ttggaatatg ggcctgataa acccgactga ttggaaaggc ttgattgacc
    27541 ttgcggtgca tgcttcggca ggccgactca tcctcgtcaa agaagggact cccatgctgg
    27601 taaatcatga tgccgtcttc cttcagagct cgataactat tgccgtagaa ttccttggta
    27661 aagagtcctt ccgtatggcc aaatggatct gtcgcatcgt tgatgataat atcgtaatca
    27721 tcttcgcagt ttcgcaaaaa gcgtagccca ttttggtagt aaatggtaac acgaggatca
    27781 tctagccctg cagcaaagtc tgggaaatac tcacgacaga cctcgaccaa catctcatcc
    27841 ggttccacga tatcgatttg ttccagttca ggatagagtg ttaatacttg ggcaacaccg
    27901 ccgtcaccac ccccaataac caatactttc tttggatttg ggtggacagc catgggaacg
    27961 tgaacggtca tttcattgta gacgaaatca tccgcatctg agaacaagac atggccattt
    28021 aaaatcagta ttttcccaaa agctggcgta tccaagactt cgatatcctg ccattcactt
    28081 tttccagcgt aaagttgctt ggctgttctc agagacaatt tgacatctgg agtatgaact
    28141 tcagaaaacc ataaatccat ctatttctcc ttatattata tttagcgcag ttagctactg
    28201 ccaaagccca agtggtatac ttggaataag ccactgtgga ttagttcatt tcctccaatc
    28261 gcttgacgat ttccgaaagg gtctaaccac agctttttgt ttcaattggt aatgagtttg
    28321 ataacgcata gacgttttat ctcgtctaag gtaacaaggc aaaaagttcg tagataacta
    28381 agtagacttg aaatactata tctggaggta ctcccatgct ttatgtgggc attgatgtcg
    28441 ctaaaaataa acacgatgtt acagccttga atgtttcagg aaaactgttc ttaaaccact
    28501 cactttttca aataataaag ctggttttga actcttagat ctgtctcttc gacagctcaa
    28561 ccaagactgt ctcatcgctc ttgaagatac tggacattat gcctttaatc tactgaactt
    28621 cctgcatgaa caaggatata aagtttacac ctacaatcct ttgctcatca aggaatttgc
    28681 caaatcatta tcacttcgca agactaaaac ggataagaaa gacgctcatg gcatcgctct
    28741 taaacttctt tctgacccca atcgtgaaca atttcaacac gataatcggc aagtagacct
    28801 aaaaatactg gctagacata ttcatcgtct caagaaaaac agtctgattg gaaagtacaa
    28861 tacactcgtt gtcttgatat catctttcct gagttggata aaatcgttgg aaagcattca
    28921 gaatatacct accaactctt gacacgctac cctaatcctc agaaaaggat tgaggcagga
    28981 tttgataagc tgatagaaat taagcgattg accgcttcta attcaagggc tttttgccgt
    29041 gctctaaaat catcgccaaa tcatcaaatt gaaataagaa atagtttaga taaaactatt
    29101 gacttttctt atagtttgtc tttctcttaa tgacgttgat atgattgacc tctggatctt
    29161 ccgtcccttg gagggagcaa ccacgttcct tggcgaattg gatatagtct acaatttctc
    29221 gtgtaatacg ttcaccagga gccaagatag gaatccctgg aggatagcac atgacaaatt
    29281 ctccacagac ctgtccaaca gaatcatcca aagttaaact ttttcttgct gaatagaagg
    29341 cttcttgcgg agacagcact aactcgggct gaatatattc tcctgctatc aaatcttttc
    29401 catctcttga atagagtctc ttaatatcag ccagagcacc aaccaagcgc tcgatgtctt
    29461 ggatgcggtc gccgatagaa atataggcca agatattgcc gatatcacca aactcgatct
    29521 gaatgtcgta ttcgtctcgc aagaggtcat aaacctcgat acctgttaag ccaataccct
    29581 gagtgtaaac tgacaactta gttacgtcaa aatcgcaaac cgaaacaccg tctattaact
    29641 cttttgagta ggcatagtag ccaccgatag cattgatttc atgacgagcg tactcggata
    29701 gctcaatgac ttcctcaaac gactctttac cacgaagggc caagttgcga cgtgaaatat
    29761 ccaaactagc catcaataag taagaggcag atgtagactg ggtcaggttt ataatctgac
    29821 gaacgtactc gggattcatc tgctccccga ttaaaagaag cgaactttgt gtcaaactcc
    29881 caccagactt atgcatggaa actgctgcca tatcagctcc tgcatccata gcagaaattg
    29941 gaagtttacc agtgaaatgc aaatgcgctc catgggcttc atctactaaa accatcatgc
    30001 cagcttcatg agccatttct gtcaacccct ttaggtctga acagatgccg tagtaagtag
    30061 gattgttgat taggatagcc ttagcatctg gatggtcctt tatggcctgt gctactcggt
    30121 cattttcaag acctaaagcg ataccaatct taggatctac actcatctcg atatagatgg
    30181 gaatggcacc acatagaacc aacgcattga tagcagattt atggacattt cgtggcagaa
    30241 taatcttatc tcctgccttg caggttgcca gaatcatagt ctgcaccgat gaagttgttc
    30301 caccaatcat tagaaaggca tggctagctc caaaagcatc tgcagccagc tcctctgcat
    30361 cacgaataat cgaaatagga tggcctaaat tatccaaggg tttcatcgaa ttgacatcaa
    30421 tgcctacaca tttttctcct aagagttcga caagttctgg atttccccgt ccacgcttgt
    30481 gacctggaac atcaaaggga acaatccttt tcttgcgtaa cttcaccaag gcttcataaa
    30541 ttggggcttg gttttgatct aactctttca aaacatactc ctttcaatat ttttaggacc
    30601 ttatgaaaac taaggaacta aaggttgact catgaaaaaa gagcaggttt tcacctgctc
    30661 tgcaatcttc tgacgtgttt attttggttt ctgttgagta tgtctgttcc cgatgtttcc
    30721 taactctcta gtagcaaata ttacgtactt tattgatcgt ttcacaagat gacgtgtgct
    30781 ttcaccacac taaaaattta tgaattagga caagtgtcct aacatcaact tataaaagta
    30841 ggcttttaac cctatcaata atgtggcttt tcaaccacgc ttcggcattc aaccctgcct
    30901 gtccgtaggc attttttact cgggtttata tttgctagaa aacatcatct cattttctaa
    30961 gctttattac tatatcatgt ttttaagaac ttgtaaagta ttttttg
//
LOCUS       DAVLHC010000024        30532 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.024, whole genome shotgun sequence.
ACCESSION   DAVLHC010000024 DAVLHC010000000
VERSION     DAVLHC010000024.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 30532)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 30532)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..30532
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.024"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(<1..279)
                     /locus_tag="VXE25_001208"
     CDS             complement(<1..279)
                     /locus_tag="VXE25_001208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000588894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HEV0771674.1"
                     /translation="MIKELYEEVQGTVYKCRNEYYLHLWELSDWDQEGMLCLHELISR
                     EEGLVDDIPRLRKYFKTKFRNRILDYIRKQESQKRRYDKEPYEEVGELS"
     gene            complement(401..2359)
                     /gene="ftsH"
                     /locus_tag="VXE25_001209"
     CDS             complement(401..2359)
                     /gene="ftsH"
                     /locus_tag="VXE25_001209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000744538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent zinc metalloprotease FtsH"
                     /protein_id="HEV0771675.1"
                     /translation="MKKQNNGLIKNPFLWLLFIFFLVTGFQYFYSGNNSGGSQQINYT
                     ELVQEITDGNVKELTYQPNGSVIEVSGVYKNPKTSKEGTGIQFFTPSVTKVEKFTSTI
                     LPADTTVSELQKLATDHKAEVTVKHESSSGIWINLLVSIVPFGILFFFLFSMMGNMGG
                     GNGRNPMSFGRSKAKAANKEDIKVRFSDVAGAEEEKQELVEVVEFLKDPKRFTKLGAR
                     IPAGVLLEGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRSLFEDAK
                     KAAPAIIFIDEIDAVGRQRGVGLGGGNDEREQTLNQLLIEMDGFEGNEGIIVIAATNR
                     SDVLDPALLRPGRFDRKVLVGRPDVKGREAILKVHAKNKPLAEDVDLKLVAQQTPGFV
                     GADLENVLNEAALVAARRNKSIIDASDIDEAEDRVIAGPSKKDKTVSQKERELVAYHE
                     AGHTIVGLVLSNARVVHKVTIVPRGRAGGYMIALPKEDQMLLSKEDMKEQLAGLMGGR
                     VAEEIIFNVQTTGASNDFEQATQMARAMVTEYGMSEKLGPVQYEGNHAMSGAQSPQKS
                     ISEQTAYEIDEEVRSLLNEARNKAAEIIQSNRETHKLIAEALLKYETLDSTQIKALYE
                     TGKMPEAVEEESHALSYDEVKSKMNDEK"
     gene            complement(2375..2917)
                     /gene="hpt"
                     /locus_tag="VXE25_001210"
     CDS             complement(2375..2917)
                     /gene="hpt"
                     /locus_tag="VXE25_001210"
                     /EC_number="2.4.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypoxanthine phosphoribosyltransferase"
                     /protein_id="HEV0771676.1"
                     /translation="MLENDIKKVLVSHDEITEAAKKLGAQLTKDYAGKNPILVGILKG
                     SIPFMAELVKHIDTHIEMDFMMVSSYHGGTASSGVINIKQDVTQDIKGRHVLFVEDII
                     DTGQTLKNLRDMFKEREAASVKIATLLDKPEGRVVEIEADYTCFTIPNEFVVGYGLDY
                     KENYRNLPYIGVLKEEVYSN"
     gene            complement(2921..4198)
                     /gene="tilS"
                     /locus_tag="VXE25_001211"
     CDS             complement(2921..4198)
                     /gene="tilS"
                     /locus_tag="VXE25_001211"
                     /EC_number="6.3.4.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA lysidine(34) synthetase TilS"
                     /protein_id="HEV0771677.1"
                     /translation="MREPDFLNHFLKKGYFKKHAKAVLALSGGLDSMFLFKVLSTYQK
                     ELEIELILAHVNHKQRIESDWEEKELRKLAAEAELPIYISNFSGEFSEARARNFRYDF
                     FQEVMKKTGATALVTAHHADDQVETILMRLIRGTRLRYLSGIKEKQVVGEIEIIRPFL
                     HFQKKDFPSIFHFEDTSNQENHYFRNRIRNSYLPELEKENPRFRDAILGIGNEILDYD
                     LAIAELSNNINVEDLQQLFSYSESTQRVLLQTYLNRFPDLNLTKAQFAEVQQILKSKS
                     QYRHPIKNGYELIKEYQQFQICKISPQADEKEDELVLHYQNQVAYQGYLFSFGLPLEG
                     ESIQQIPVSRETSIHIRHRKTGDVLIQNGHRKKLRRLFIDLKIPMEKRNSALIIEQFG
                     EIVSILGIATNNLSKKTKNDIMNTVLYIEKIDR"
     gene            complement(4195..5463)
                     /locus_tag="VXE25_001212"
     CDS             complement(4195..5463)
                     /locus_tag="VXE25_001212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001224749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class A beta-lactamase-related serine hydrolase"
                     /protein_id="HEV0771678.1"
                     /translation="MRKFLIILLLPSFLTISKVVSTEKEVVYTSKEIYYLSQSDFGIY
                     FREKLSSPMVYGEVPVYANEDLVVESGKLTPKTSFQITEWRLNKQGIPVFKLSNHQFI
                     AADKRFLYDQSEVTPTIKKVWLESDFKLYNSPYDLKEVKSSLSAYSQVSIDKTMFVEG
                     REFLHIDQAGWVAKESTSEEDNRMSKVQEMLSEKYQKDSFSIYVKQLTTGKEAGINQD
                     EKMYAASVLKLSYLYYTQEKINEGLYQLDTTVKYVSAVNDFPGSYKPEGSGSLPKKED
                     NKEYSLKDLITKVSKESDNVAHNLLGYYISNQSDATFKSKMSAIMGDDWDPKEKLISS
                     KMAGKFMEAIYNQNGFVLESLTKTDFDSQRIAKGVSVKVAHKIGDADEFKHDTGVVYA
                     DSPFILSIFTKNSDYDTISKIAKDVYEVLK"
     gene            complement(5583..5951)
                     /locus_tag="VXE25_001213"
     CDS             complement(5583..5951)
                     /locus_tag="VXE25_001213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septum formation initiator family protein"
                     /protein_id="HEV0771679.1"
                     /translation="MSKNIVQLNNSFIQNEYQRRRYLMKERQKRNRFMGGVLILIMLL
                     FILPTFNLAQSYQQLLQRRQQLADLQTQYQTLSDEKDKETAFATKLKDEDYAAKYTRA
                     KYYYSKSREKVYTIPDLLQR"
     gene            complement(5944..6210)
                     /locus_tag="VXE25_001214"
     CDS             complement(5944..6210)
                     /locus_tag="VXE25_001214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001234972.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding S4 domain-containing protein"
                     /protein_id="HEV0771680.1"
                     /translation="MRLDKYLKVSRIIKRRTVAKEVADKGRIKVNGILAKSSTDLKVN
                     DQVEIRFGNKLLLVKVLEMKDSTKKEDAAGMYEIISETRVEENV"
     gene            complement(6278..9802)
                     /gene="mfd"
                     /locus_tag="VXE25_001215"
     CDS             complement(6278..9802)
                     /gene="mfd"
                     /locus_tag="VXE25_001215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000258090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription-repair coupling factor"
                     /protein_id="HEV0771681.1"
                     /translation="MVTLLDLLSENDQIKKWHQNLTDKKRQLILGLSTSTKALAIASS
                     LEKEDRIVLLTSTYGEAEGLVSDLISILGEELVYPFLVDDAPMVEFLMSSQEKIISRV
                     EALRFLTDSSKKGILVCNIAASRLILPSPNAFKDSIVKISVGEEYDQHAFIHQLKENG
                     YRKVTQVQTQGEFSLRGDILDIFEISQLEPCRIEFFGDEIDGIRSFEVETQLSKENKT
                     ELTIFPASDMLLREKDYQRGQSALEKQISKTLSPILKSYLEEILSSFHQKQSHADSRK
                     FLSLCYDKTWTVFDYIEKDTPIFFDDYQKLMNQYEVFERELAQYFTEELQNSKAFSDM
                     QYFSDIEQIYKKQSPVTFFSNLQKGLGNLKFDKIYQFNQYPMQEFFNQFSFLKEEIER
                     YKKMDYTIILQSSNSMGSKTLEDMLEEYQIKLDSRDKTSICKESVNLIEGNLRHGFHF
                     VDEKILLITEHEIFQKKLKRRFRRQHVSNAERLKDYNELEKGDYVVHHIHGIGQYLGI
                     ETIEIKGIHRDYVSVQYQNGDQISIPVEQIHLLSKYISSDGKAPKLNKLNDGHFKKAK
                     QKVKNQVEDIADDLIKLYSERSQLKGFAFSADDDDQDAFDDAFPYVETDDQLRSIEEI
                     KRDMQASQPMDRLLVGDVGFGKTEVAMRAAFKAVNDHKQVVILVPTTVLAQQHYTNFK
                     ERFQNFAVNIDVLSRFRSKKEQTATLEKLKNGQVDILIGTHRVLSKDVVFADLGLMII
                     DEEQRFGVKHKETLKELKKQVDVLTLTATPIPRTLHMSMLGIRDLSVIETPPTNRYPV
                     QTYVLEKNDSVIRDAVLREMERGGQVYYLYNKVDTIVQKVSELQELIPEASIGYVHGR
                     MSEVQLENTLLDFIEGQYDILVTTTIIETGVDIPNANTLFIENADHMGLSTLYQLRGR
                     VGRSNRIAYAYLMYRPEKSISEVSEKRLEAIKGFTELGSGFKIAMRDLSIRGAGNLLG
                     KSQSGFIDSVGFELYSQLLEEAIAKRNGNANANTRTKGNAELILQIDAYLPDTYISDQ
                     RHKIEIYKKIRQIDNRVNYEELQEELIDRFGEYPDVVAYLLEIGLVKSYLDKVFVQRV
                     ERKDNKRKDNKITIQFEKVTQRLFLAQDYFKALSVTNLKAGIAENKGLMELVFDVQNK
                     KDYEILEGLLIFGESLLEIKEFKEENSI"
     gene            complement(9803..10372)
                     /locus_tag="VXE25_001216"
     CDS             complement(9803..10372)
                     /locus_tag="VXE25_001216"
                     /EC_number="3.1.1.29"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="HEV0771682.1"
                     /translation="MTKLLVGLGNPGDKYFETKHNVGFMLIDQLAKKQNVTFTHDKIF
                     QADLASFFLNGEKIYLVKPTTFMNESGKAVHALLTYYGLDIDDLLIIYDDLDMEVGKI
                     RLRAKGSAGGHNGIKSIIQHIGTQVFNRVKIGIGRPKNGMSVVHHVLSKFDRDDYIGI
                     LQSVDKVDDSVNYYLQEKNFEKTMQRYNG"
     gene            complement(10443..11558)
                     /gene="ychF"
                     /locus_tag="VXE25_001217"
     CDS             complement(10443..11558)
                     /gene="ychF"
                     /locus_tag="VXE25_001217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002269933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redox-regulated ATPase YchF"
                     /protein_id="HEV0771683.1"
                     /translation="MALTAGIVGLPNVGKSTLFNAITKAGAEAANYPFATIDPNVGMV
                     EVPDERLQKLTEMITPKKTVPTTFEFTDIAGIVKGASKGEGLGNKFLANIREVDAIVH
                     VVRAFDDENVMREQGREDAFVDPLADIDTINLELILADLESVNKRYARVEKMARTQKD
                     KESVAEFNVLQKIKPVLEDGKSARTIEFTDEEQKVVKGLFLLTTKPVLYVANVDEDVV
                     SEPDSIDYVKQIREFAATENAEVVVISARAEEEISELDDEDKKEFLEAIGLTESGVDK
                     LTRAAYHLLGLGTYFTAGEKEVRAWTFKRGMKAPQAAGIIHSDFEKGFIRAVTMSYED
                     LVKYGSEKAVKEAGRLREEGKEYIVQDGDIMEFRFNV"
     gene            complement(11678..12844)
                     /locus_tag="VXE25_001218"
     CDS             complement(11678..12844)
                     /locus_tag="VXE25_001218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000704683.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HEV0771684.1"
                     /translation="MKITEYTKKDGSTVYRSSVYLGIDTVTGKKVKTTISGRTKRELK
                     AKALQAQIDFEKGGATVYKAVEIKTYAELVENWLETYCHTVKKSTLMGTKFKIDKYLL
                     PAFGNYRLDKLTPPIIQKQVNQWAKDYNQLGKGFQEYPLLHSLNKRILKYAVSLQAIP
                     FNPARDVIVPRRKEKEGQKLKYLDDDNLKKFLTYLEQLPNTYKNFYDTVLYKTLLATG
                     LRIRECLALKWSDIDLKNGTLDVNKTLNIIKEITGPKTKSSIRVIDLDNKTVLMLRLY
                     KARQSQIGKEMGLTYEKVFSNSFDKHIDARMLSFRLVKHLERAGCPRFTFHAFRHTHA
                     SILLNAGLPYKEIQIRLGHAKLSMTMDIYSHLSKDNQKNATSFYEKAIEKLKSS"
     gene            complement(12940..13392)
                     /locus_tag="VXE25_001219"
     CDS             complement(12940..13392)
                     /locus_tag="VXE25_001219"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000357940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system death-on-curing
                     family toxin"
                     /protein_id="HEV0771685.1"
                     /translation="MDKINYFSAEEAILLHDIEVIEKIGGLHGVKDKGRVFSVFEHLQ
                     NDDYYPDFETKLTVLVFNTVQFHMFNDGNKRSSIVFGIKFLTINHLDYLIPFFIETME
                     NIVLWVAMGLIDFNFLKEIISSILYYEELTEKVKEKLVQIALAEENNK"
     gene            complement(13392..14396)
                     /locus_tag="VXE25_001220"
     CDS             complement(13392..14396)
                     /locus_tag="VXE25_001220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003055091.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HEV0771686.1"
                     /translation="MTDLTTSQIERQNILNNSLALQKAEEILKVPGFYFEDTFYFTNS
                     QLATFFEVDIRTIERLVEAHKTELTENGYHTLRGEKLAKFKENAFATDTNVGSKVTQL
                     SISSFRTLLNFAMLLTNSDIAKQVRNTLLDIVINVLTEKTGGHVKFINQRDKNYLSTA
                     LEEDNARKIFTNAIDKYVSGSNFKYGQLTNEIYKAIFKERASEYKKILKLNKNDNARA
                     TMYSEVLIVIASFEKGVAYEIEQKSKSSNQKLTNTDVIEIIQRLANHPMQEPHLMHAR
                     EKMASRDLSFRNAKHEKLAEYIRPISEEDFERFIGEQSKSLSEQIDEHRQVFERLRDK
                     "
     gene            complement(14545..15501)
                     /locus_tag="VXE25_001221"
     CDS             complement(14545..15501)
                     /locus_tag="VXE25_001221"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001107586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEV0771687.1"
                     /translation="MAKNSPQDLENREYFSKRLNLLMEQKGVRQIDLHNALDIPKSTI
                     TGYVKGKSLPTAGNLQKIADFLNVKKSFLDLRFIDTVSTSTLKELLDNNQREKVFEMF
                     FNKIKEILSFKKDYMNMEYIRGKIAFDQGVLGRVLQSSIINPGIVEIFNGLDLSDISK
                     NNEALLLSKQREAREYAYNNVLTMITNEYITRLINVIEREQALNTSYVHSEISNLINS
                     LNNKIDSYGAVVFEVNEIIEKIGIQDRKILGYCLQRKISSVQNEINDLVHNNTNNSFC
                     VTKNKIFTEKSDIIDTIEFDYYKGIQNRLNDLAEEIREHFSD"
     gene            15658..15891
                     /locus_tag="VXE25_001222"
     CDS             15658..15891
                     /locus_tag="VXE25_001222"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000438800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEV0771688.1"
                     /translation="MEQWTLKACRVNAGYTLRQVAKKVNKNFQTVSKYEKDSTYIPFE
                     LLKELSAIYQVKLDNIFLGDSTKKIELNKRELQ"
     gene            15981..16607
                     /locus_tag="VXE25_001223"
     CDS             15981..16607
                     /locus_tag="VXE25_001223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rha family transcriptional regulator"
                     /protein_id="HEV0771689.1"
                     /translation="MELVYMDGKKEPYTLSSIVAECAEVKHRHLKILLNKHREDFESF
                     GKVQFKISPSESGQNVRDYILNEQQATLLITYLRNTEPVKEFKKNLVKAFFEMREELS
                     KFRMQRALEKPKRKTLHDSIKTWEAKPKHAHSTMNNLLLKAVTDMNAKQLVKSRGGYN
                     GIDSLTSDELEQYQAFEDMVIAMIGLNMSYQEIKAMAFRNKKTRQRSV"
     gene            17059..17511
                     /locus_tag="VXE25_001224"
     CDS             17059..17511
                     /locus_tag="VXE25_001224"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000141102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771690.1"
                     /translation="MTETTYENLTRRINRISAEMQEIGEKNGLSRLSLLASQTKFIKE
                     ELSRLLWIELPELNDSHKIEAVSKSTTGMFFHPGIFEMDAMRQAFFKRQAMHFFENEA
                     EQQAYIEHAEKEYLEATITLKDILFNSKNGTQRVNKSCLIEKFEEAMQ"
     gene            17508..17708
                     /locus_tag="VXE25_001225"
     CDS             17508..17708
                     /locus_tag="VXE25_001225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000171265.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771691.1"
                     /translation="MTLDLDNMTQAEFDKQMAEIKERNPNIFQLISDFLDRKVTPEEV
                     DEFLKMERAEQVEYIKNYQARV"
     gene            17710..17925
                     /locus_tag="VXE25_001226"
     CDS             17710..17925
                     /locus_tag="VXE25_001226"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001003747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771692.1"
                     /translation="MNELDISNTQAAVLIVILIGLLLYLNHRDRKKSAQIERENQQTI
                     KTPSEDLNPDYGRYIQLAGVNVWGGME"
     gene            17922..18215
                     /locus_tag="VXE25_001227"
     CDS             17922..18215
                     /locus_tag="VXE25_001227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000122652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771693.1"
                     /translation="MSYTMNLYPDIEKIPDETYFTKEIFLATCLNNTIRIAVARGVLT
                     SQLLDKETKEVVCKTLDTIIENQKAILQGVASGQITFVNKSKGEEGLDESIRE"
     gene            18196..18537
                     /locus_tag="VXE25_001228"
     CDS             18196..18537
                     /locus_tag="VXE25_001228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000058847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HEV0771694.1"
                     /translation="MSLSENDKRVLRLIKVGAENSITGSEISLTTKLTERTVRDIIKR
                     LVVKHNIPIVGVRCGVFSGYFIPANKGELLDGAKAFYNQVQEESKRLAVLMNSDLESY
                     KETLKEVGGYV"
     gene            18530..18805
                     /locus_tag="VXE25_001229"
     CDS             18530..18805
                     /locus_tag="VXE25_001229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000492137.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771695.1"
                     /translation="MFSLSRESEQDLAHGILEVVERYLEAREKVPPRLTKLINRVELK
                     EELKISDNTLNKWESQGLRRYQPPDDGARIIFYLVDDIRRFMGVENG"
     gene            18945..19805
                     /locus_tag="VXE25_001230"
     CDS             18945..19805
                     /locus_tag="VXE25_001230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000158206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primase alpha helix C-terminal domain-containing
                     protein"
                     /protein_id="HEV0771696.1"
                     /translation="MTIYEARGFQSNLVYPFDKMEPFQYIERFKPLVVPESADPEEYK
                     RTQAPYCLSGKVMPEKNGSYKRNNSSLIYRDLIFLDYDDIQGTTEDFIEAVSSALFGY
                     SYILYPTIKHSIEKPRFRLVVKSNNVMNEATYKQVVKEIADKIGLPFDMASLTWSQLQ
                     GLPVTTGDPATYQKIVEHGLDYPVPKVEPRAKQGTTERYKPRVSGQRSMTMRIIDTLF
                     NGFGDEGGRNVAVTRFVGLLFNKWVDCDLETAYELTKIANSVTVEPLPIEELDRTFSS
                     IARAEYRKRG"
     gene            19858..21327
                     /locus_tag="VXE25_001231"
     CDS             19858..21327
                     /locus_tag="VXE25_001231"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000434361.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA primase family protein"
                     /protein_id="HEV0771697.1"
                     /translation="MEQEHPPRTMKELENRIFKAGEEWRAEHTETKVNETTGDVTEKV
                     AMPQTFTVAKILSEIVTFTFISKSNIPDYSLLYIYDLDEGIYTASNDLFNLLCKTFDV
                     RIKPREWPQIKLMVRTLAKIRKPLESANLVPVKNGIIDLRTKELLPFSPKYVITSKIS
                     TAYHAPKRVPTDREGKTFDDWLNSIACNDSELVTLFWQIILEAINPNHTRNKFAIFYG
                     DGNNGKGTFQRFLINLIGESNISALKPAQFGEKHNLETLVGKVCNIGDEAPNEYLKNP
                     SDLMSITSGDTVLVNPKGRPAFEATFKLFNIFSGNYIPNGGNKTKGWYRRIMIVPFNA
                     DFNGEKEKPWIKNEFLANKEVLEYALYKAINQEPFTHFIEPKAVKGLLEEYQEDNDYL
                     LSWVKHEYMEKGWHELDVVPVFIVTRSLKHYAEDMGIPKPNVYGAGKETIKHLQQLTP
                     NRYSLRKKRVPSEDFEKLEAWDVDKIKMRTPQHSITKQE"
     gene            21668..21835
                     /locus_tag="VXE25_001232"
     CDS             21668..21835
                     /locus_tag="VXE25_001232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000865230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771698.1"
                     /translation="MKVKLFEYTRRWEKEDFEKEINDFMATVEVLDVKFSGTPSSESF
                     NSVAIVLVLYR"
     gene            21918..22448
                     /locus_tag="VXE25_001233"
                     /pseudo
     CDS             21918..22448
                     /locus_tag="VXE25_001233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000173118.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            22519..23018
                     /locus_tag="VXE25_001234"
                     /pseudo
     CDS             22519..23018
                     /locus_tag="VXE25_001234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255091.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            23705..24115
                     /locus_tag="VXE25_001235"
     CDS             23705..24115
                     /locus_tag="VXE25_001235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000187312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1492 domain-containing protein"
                     /protein_id="HEV0771699.1"
                     /translation="MTPEQVKEKLEGVKWINKEIEGLYLELAALESGIIKKQELSNTR
                     VQTSRVNTTENNPISVLKLKEDTLQRIERLNEERMEISRLIDKLANPLERSVLRLFYL
                     NVLDAWQVAEEIDKSKTAVYIIRQKAIEHLANVG"
     gene            24271..24663
                     /locus_tag="VXE25_001236"
     CDS             24271..24663
                     /locus_tag="VXE25_001236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000417885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HEV0771700.1"
                     /translation="MELDKFKTMMNVRERMTYFLRFQRMAGSENQVTIDEEAWKLVLP
                     YRWDLSGEHEKAIREGLEIFAQDINSIENKRARKYFIIHYCYMRKKTMSECVEMAATS
                     STSYHRYKQIAVLNFARIHQNGELEVYK"
     gene            24717..24875
                     /locus_tag="VXE25_001237"
     CDS             24717..24875
                     /locus_tag="VXE25_001237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000568693.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771701.1"
                     /translation="MIEDFLIDLENIQLEDMEIDFNMDIDIDLNIDFEIDVDLDDLDL
                     TLLQELEA"
     gene            complement(25304..25498)
                     /locus_tag="VXE25_001238"
     CDS             complement(25304..25498)
                     /locus_tag="VXE25_001238"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF951 family protein"
                     /protein_id="HEV0771702.1"
                     /translation="MYQVGNFVEMKKSHACTIKSTGKKANCWEITRVGADIKIKCSNC
                     EHVVMMGRYDFERKMNKIID"
     gene            complement(25563..26699)
                     /gene="dnaN"
                     /locus_tag="VXE25_001239"
     CDS             complement(25563..26699)
                     /gene="dnaN"
                     /locus_tag="VXE25_001239"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000581170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit beta"
                     /protein_id="HEV0771703.1"
                     /translation="MIHFSINKNLFLQALNTTKRAISSKNAIPILSTVKIDVTNEGIT
                     LIGSNGQISIENFISQKNEDAGLLITSLGSILLEASFFINVVSSLPDVTLDFKEIEQN
                     QIVLTSGKSEITLKGKDSEQYPRIQEISASTPLILETKLLKKIINETAFAASTQESRP
                     ILTGVHFVLSQHKELKTVATDSHRLSQKKLTLEKNSDDFDVVIPSRSLREFSAVFTDD
                     IETVEIFFANNQILFRSENISFYTRLLEGNYPDTDRLIPTDFNTTITFNVVNLRQSME
                     RARLLSSATQNGTVKLEIKDGVVSAHVHSPEVGKVNEEIDTDQVTGEDLTISFNPTYL
                     IDSLKALNSEKVTISFISAVRPFTLVPADTDEDFMQLITPVRTN"
     gene            complement(26858..28219)
                     /gene="dnaA"
                     /locus_tag="VXE25_001240"
     CDS             complement(26858..28219)
                     /gene="dnaA"
                     /locus_tag="VXE25_001240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosomal replication initiator protein DnaA"
                     /protein_id="HEV0771704.1"
                     /translation="MKEKQFWNRILEFAQERLTRSMYDFYAIQAELIKVEENVATIFL
                     PRSEMEMVWEKQLKDIIVVAGFEIYDAEITPHYIFTKPQDTTSSQVEEATNLTLYNYS
                     PKLVSIPYSDTGLKEKYTFDNFIQGDGNVWAVSAALAVSEDLALTYNPLFIYGGPGLG
                     KTHLLNAIGNEILKNIPNARVKYIPAESFINDFLDHLRLGEMEKFKKTYRSLDLLLID
                     DIQSLSGKKVATQEEFFNTFNALHDKQKQIVLTSDRSPKHLEGLEERLVTRFSWGLTQ
                     TITPPDFETRIAILQSKTEHLGYNFQSDTLEYLAGQFDSNVRDLEGAINDITLIARVK
                     KIKDITIDIAAEAIRARKQDVSQMLVIPIDKIQTEVGNFYGVSIKEMKGSRRLQNIVL
                     ARQVAMYLSRELTDNSLPKIGKEFGGKDHTTVIHAHAKIKSLIDQDDNLRLEIESIKK
                     KIK"
     gene            complement(28432..29190)
                     /locus_tag="VXE25_001241"
     CDS             complement(28432..29190)
                     /locus_tag="VXE25_001241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000410347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParB/RepB/Spo0J family partition protein"
                     /protein_id="HEV0771705.1"
                     /translation="MEKFEMISITDIQKNPYQPRKEFDREKLDELAQSIKENGVIQPI
                     IVRQSPVIGYEILAGERRYRASLLAGLRSIPAVVKQISDQEMMVQSIIENLQRENLNP
                     IEEARAYESLVEKGFTHAEIADKMGKSRPYISNSIRLLSLPEQILSEVENGKLSQAHA
                     RSLVGLNKEQQDYFFQRIIEEDISVRKLEALLTEKKQKKQQKTNHFIQNEEKQLRKLL
                     GLDVEIKLSKKDSGKIIISFSNQEEYSRIINSLK"
     gene            complement(29248..30429)
                     /locus_tag="VXE25_001242"
     CDS             complement(29248..30429)
                     /locus_tag="VXE25_001242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000681590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine protease"
                     /protein_id="HEV0771706.1"
                     /translation="MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNS
                     NNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSANRQNSVFGNDDTDTDSQRISSE
                     GSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
                     EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAI
                     STKAIQTDTAINPGNSGGPLINIQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINI
                     IEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVVVRSVQSNMPANGHL
                     EKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLE
                     S"
BASE COUNT         9598 a         5677 c         5440 g         9817 t
ORIGIN      
        1 actgagctca cccacttctt catagggttc tttatcgtat ctacgcttct gactttcctg
       61 cttacggata tagtctaaaa ttcgatttcg aaacttggtt ttgaaatatt tccttaaacg
      121 tggaatatcg tctaccagtc cttcttctct actaatcaat tcatgtaagc agagcatgcc
      181 ttcttggtcc caatccgaca attcccataa atgaaggtaa tattcatttc tacacttata
      241 cacagtccct tggacttctt catacaattc tttaatcata attttcccct ttctagatac
      301 agtctaacag attagaaaac acatttgttc cattttctcc attctgttcc ctttagctcc
      361 taaactgcac aaaaaagaga ggctccagcc tctctcaggg ttatttttcg tcattcattt
      421 ttgactttac ttcatcatag gatagtgcat gagattcctc ttctactgct tcaggcatct
      481 ttcctgtttc gtaaagagct ttaatttgtg tactatccaa tgtttcgtat ttcaataatg
      541 cttctgcaat taacttgtga gtttcacgat ttgactgaat aatttcagca gctttatttc
      601 gtgcctcatt taataatgaa cgaacctctt catcaatttc ataagctgtt tgttctgaaa
      661 ttgatttttg aggactctgt gcaccagaca tagcatggtt tccttcatat tgtactgggc
      721 caagtttttc actcataccg tactctgtaa ccattgcacg cgccatttgt gtcgcttgtt
      781 caaagtcgtt tgaagctcct gtagtttgga cattaaagat aatttcttca gctacacgtc
      841 cacccattaa gccagccaat tgctctttca tatcttcttt agatagaagc atttgatcct
      901 ctttaggaag tgcaatcatg tatccgcctg cacggccgcg tggtacaatt gtaaccttat
      961 ggacaacgcg agcattcgac aagactagac caacaatggt atgtcctgcc tcatggtaag
     1021 caaccaattc tcgttctttt tgtgaaactg tcttatcttt cttagaaggt ccagcaataa
     1081 ctctatcttc tgcttcatca atatctgaag catcaattat cgatttattg cgacgagcag
     1141 caactaaagc tgcttcattc aagacattct ctaaatcagc accaacaaag cctggagttt
     1201 gttgagccac taatttcaaa tcaacatctt ctgctaaagg cttgttctta gcgtgaactt
     1261 tcaagattgc ttcacgacct ttaacatcag gacggccaac caatactttt ctatcaaaac
     1321 gtcctggacg caaaagggca ggatcaagta catctgaacg gtttgtcgca gcgatgacga
     1381 taatcccttc atttccctca aaaccatcca tctcaatcaa aagttggttc aaggtttgtt
     1441 cacgttcgtc attacctccg ccgagaccga ctccacgttg acgtccaaca gcatcaattt
     1501 catcgataaa gatgatagct ggtgctgctt ttttggcatc ctcaaaaaga gagcgaacac
     1561 gactagctcc aactccgaca aacatttcta caaagtcaga acctgagata ctaaagaatg
     1621 gaacacctgc ttctccagcg actgccttag caagcaaagt cttacctgtc cccggaggtc
     1681 cctccaaaag aacacctgct ggaatacggg ctccaagttt tgtgaatcgt tttggatctt
     1741 ttaagaactc aacaacttca actagttctt gtttttcttc ctcagctcca gcaacatctg
     1801 aaaatcttac tttaatatct tctttatttg ctgctttagc cttactacgt ccaaaactca
     1861 ttggattacg gccattgcct cctcccatat ttcccatcat agagaatagg aagaagaata
     1921 gaattccaaa tggcacaatg gatacgagta gattaatcca tataccactt gaactttcat
     1981 gcttaacagt tacttctgct ttatggtcag tagcaagttt ttgcaattct gatacggtag
     2041 tatctgcagg aagaatagtg ctggtaaatt tctctacctt agtaacagat ggcgtgaaaa
     2101 actgaatgcc tgttccttct ttacttgttt taggattttt atagacacca gaaacttcga
     2161 taacactacc atttggttgg taagttaatt cttttacatt accatcggta atttcttgta
     2221 ccaactcagt atagttgatt tgctgacttc ctcctgagtt attcccagaa tagaaatact
     2281 ggaatcctgt cacaaggaaa aagataaata ataaccatag aaaaggattt ttaattaaac
     2341 cattattttg ttttttcatt aaagattatt ctttctaatt tgaatacact tcctctttca
     2401 atactccaat ataaggaaga ttacgataat tttctttgta gtctaaacca taacctacta
     2461 caaactcatt tgggatagta aagcaggtat agtctgcctc aatttctaca acacgtcctt
     2521 ctggtttatc caacaaggtt gcaattttaa cagaagctgc ttctctttct ttaaacatat
     2581 ctcgcaaatt cttcaaagtt tgacctgtat caatgatatc ttctacaaat agaacatgtc
     2641 ttcctttgat atcttgagtc acatcttgtt taatattgat aacaccacta cttgctgttc
     2701 caccatggta gctagaaacc atcatgaagt ccatttcaat atgtgtatca atatgtttga
     2761 ccaattcagc cataaaagga atagatcctt ttaaaatccc aactaagatt ggattttttc
     2821 ctgcatagtc tttagttaat tgagcaccta gttttttagc tgcttctgta atttcatcgt
     2881 gtgaaacgag gactttttta atatcgtttt ctaacatttt ttacctatct attttttcta
     2941 tataaagtac agtgttcatt atatcatttt tcgttttttt actcaaatta ttggtcgcaa
     3001 ttcccaaaat tgagacaatt tcaccaaatt gctcaataat aagagcagag tttctctttt
     3061 ccatagggat tttcaaatca ataaataaac gtctgagttt ttttctatgc ccattttgaa
     3121 tcaaaacatc tcctgttttt cgatgacgaa tgtgtatgga tgtttcacgt gaaacaggta
     3181 tttgttgaat tgattcacct tctaatggaa gtccaaagga aaataaatat ccttgataag
     3241 ctacctgatt ttgatagtgt aacacaagtt catcttcctt ttcatcagcc tgcggactga
     3301 ttttacaaat ctgaaactgt tggtactctt ttatcaattc atagccattt ttaatcggat
     3361 gacgatactg gcttttagat tttaaaatct gctgaacttc agcaaactga gcttttgtaa
     3421 gattcaaatc tggaaaacga ttcagataag tttgaagtaa aactctttgt gtagactcag
     3481 agtaagaaaa taactgctgt aaatcttcca cattaatatt gttagataat tcagctattg
     3541 ccaaatcata atctaaaatt tcattgccaa tgcctaagat tgcatcccta aatcgaggat
     3601 tttctttttc caattctggt aagtaagagt ttcgaatacg atttcgaaaa taatgattct
     3661 cctgatttga tgtatcttca aagtgaaaaa ttgatggaaa gtcttttttc tgaaaatgca
     3721 agaagggacg aatgatttct atctctccga ctacttgctt ctccttaatt cctgatagat
     3781 agcgcaagcg agttcctcga atcaagcgca tcaaaatcgt ttccacctga tcatcagcat
     3841 ggtgggcagt gactaaagct gtcgcacctg tctttttcat aacctcttga aaaaaatcat
     3901 aacgaaaatt tcgtgcacgc gcttctgaaa attctcctga aaaattgctg atataaatag
     3961 gaagctctgc ttcagcagcc aacttcctta attccttttc ttcccaatct gattcaattc
     4021 tctgcttatg attcacatga gccagaatca attcaatctc taactctttt tgataagtag
     4081 acaatacctt aaatagaaac atagaatcta atccaccaga aagagctaga accgccttag
     4141 catgcttttt gaaatatccc ttcttgagaa aatgatttaa aaaatctggt tccctcattt
     4201 tagaacctca taaacatcct tggctatctt agaaatcgta tcataatcag aattcttagt
     4261 gaaaatagaa agaataaatg gagaatctgc atagacaaca cccgtatcat gcttaaattc
     4321 atccgcatct ccaattttat gagctacttt aacagaaaca cctttggcaa ttcgctgact
     4381 atcaaaatct gttttagtca aagactctag cacaaatcca ttttgattat aaatagcttc
     4441 cataaacttc ccggccatct tagaagaaat caatttttct tttggatccc aatcatctcc
     4501 cataatggca gacatcttgg atttgaatgt ggcatcagat tggtttgaaa tgtaatatcc
     4561 caatagatta tgagctacat tatcagattc ttttgatact ttcgtaatta aatcctttaa
     4621 agaatattct ttattatctt cttttttagg aagactacca cttccctctg gtttataaga
     4681 acctggaaaa tcattgactg cagatacgta ttttacagtc gtatctaact gataaagacc
     4741 ctcatttatt ttttcttgcg tataatagag ataggagagt ttcaaaacgc tggctgcata
     4801 catcttttca tcttgattga taccagcttc ttttccagta gtcagttgct taacataaat
     4861 agagaaagaa tctttctgat atttttcaga taacatttct tgaactttac tcatccgatt
     4921 atcttcttca gaagttgatt ctttagctac ccatccagcc tgatcaatat gtagaaattc
     4981 tcttccttct acaaacatgg tcttgtcgat tgatacttgc gaataagctg ataaggatga
     5041 tttcacttct tttaaatcat aaggactatt gtacagttta aagtcagatt ctaaccatac
     5101 tttttttatt gttggagtta cctctgattg atcatataaa aatcgtttgt ccgcagctat
     5161 aaattgatga tttgatagct taaatactgg aattccttgt ttatttaagc gccactcggt
     5221 tatttgaaaa cttgttttgg gagtcaattt cccagattcc actactaaat cttcattcgc
     5281 ataaacagga acctctccat aaaccatggg agaacttaat ttttctctaa aataaatacc
     5341 aaagtcagat tgtgaaaggt aataaatttc tttcgaagta tagacgactt ctttttctgt
     5401 gctaacgact tttgaaatgg tcaaaaaact tggtaacaac aaaataatta agaatttacg
     5461 cattcttcct ttccttttct tcttgtaaac gcaataattg atttttatca gccaattctt
     5521 ccagcttttc atctgacaaa ctcaaaaatt gctctattac gtctaataaa ttttccattt
     5581 tatcaccttt gaagcaagtc aggaatcgta taaacttttt ccctcgactt agaataatag
     5641 tacttcgctc gtgtatattt agcagcataa tcttcatctt tcaacttggt agcaaatgct
     5701 gtctccttat ccttttcatc actcaaagtt tgatactgag tttgcaagtc tgctaattgc
     5761 tgacgtcttt ggagtaattg ctgataactc tgcgctaaat taaaagttgg caagataaat
     5821 aatagcataa tcaaaatcaa tacccctccc ataaaacgat tccgtttttg tcgttctttc
     5881 atcaggtagc gacgacgttg gtattcattt tgaataaaag aattattcaa ttgtacaata
     5941 tttttagaca ttttcttcta cccgtgtttc actgataatt tcatacattc ctgctgcatc
     6001 ttcttttttt gtactatctt tcatctctag tacttttaca agcagcaact tattgccaaa
     6061 gcgaatttca acttggtcat taactttcaa gtccgttgaa cttttggcca agattccatt
     6121 aaccttgatt ctacctttat ctgctacttc ctttgcgact gtacgacgct tgataattcg
     6181 cgatactttt aaatatttat ctaatctcat ccttattacc tcaatttatt attgtaccat
     6241 ttttatctat ttttatctat tttatagaag aaaaatatca aatggaattt tcttccttaa
     6301 actcttttat ctctaataaa ctttctccaa aaatcagcag accttctaaa atttcataat
     6361 ctttcttatt ttggacatca aatacaagct ccattaatcc cttattctca gcgatgcctg
     6421 cttttaagtt cgttacggat aaagctttaa aataatcttg agctaaaaac aatcgttgag
     6481 tgactttttc aaattgaatt gtaattttat tatcttttct tttattatct tttctttcca
     6541 cacgttgaac aaagaccttg tccaagtatg atttaaccaa accaatctct aaaagatagg
     6601 ctactacatc tgggtattct ccaaaacggt ctatcaactc ctcttgtaac tcttcataat
     6661 tgacacggtt gtcaatttga cgaattttct tgtaaatttc aatcttatgt cgttgatcag
     6721 aaatataagt atcaggaaga taggcatcaa tttgcaaaat caactcagca ttccctttgg
     6781 ttcttgtgtt agcgttagca ttaccgtttc gtttagcaat agcttcctct aataactgcg
     6841 aatacaattc aaaaccaaca gaatcaatga aaccagactg ggattttcct aaaagatttc
     6901 ctgctccacg aatcgaaaga tctcgcattg caatcttaaa gccagagccc aattctgtaa
     6961 atcctttaat cgcttctaat ctcttttcag agacttcact gattgatttt tctggacgat
     7021 acatgagata agcataagca atacgattac tacgaccgac tcttcctctt aactgatata
     7081 aggttgacaa gcccatatgg tccgcatttt caataaataa agtattagca tttggaatgt
     7141 ccacccctgt ctcaataata gtagtcgtca ccaagatatc gtattgtccc tcaataaagt
     7201 ctaatagagt attttccaac tggacttcac tcattcgacc atgaacatat ccaatcgaag
     7261 cctccggaat caactcctgt aattctgaaa ccttctgaac aattgtgtca actttgttgt
     7321 aaagataata aacttgacct ccacgctcca tttcacgcaa gacagcatca cgaatgacac
     7381 tatcattctt ttccaaaaca taggtctgaa caggatagcg attagtcggc ggagtttcaa
     7441 taacagataa atctctgatt cccagcatag acatatggag ggtacgaggg attggcgtag
     7501 cggtcaaggt taggacatcc acttgtttct tcagttcttt caaagtttcc ttatgcttga
     7561 caccaaatcg ctgttcctca tcaataatca tcaagcccaa atcagcaaac acaacatctt
     7621 ttgacaaaac acgatgtgtt ccaatcaaaa tatcgacttg accgtttttc aatttttcaa
     7681 gtgttgcagt ctgctctttt ttacttctaa agcgactcaa cacatcaata ttaactgcaa
     7741 aattttggaa tcgttcctta aaattcgtat agtgctgttg cgctaaaacc gtcgtcggaa
     7801 ctagaatgac aacctgtttg tgatcattga ctgctttaaa ggctgcacgc atagcaactt
     7861 cagtctttcc aaaaccaaca tccccaacta aaagtcgatc cattggctga gaagcctgca
     7921 tatccctctt gatttcctca atactacgaa gttgatcatc cgtttcaaca taagggaaag
     7981 catcatcaaa ggcatcttga tcatcatcat cagctgagaa agcaaaaccc ttcaactgac
     8041 tacgttcaga gtagagtttg attaaatcat cagctatatc ctctacctgg ttcttaacct
     8101 tttgcttggc ctttttaaaa tgaccgtcat ttaatttatt gagttttgga gctttaccat
     8161 cacttgaaat atatttggac agtagatgaa tctgttccac ggggatagaa atttgatcac
     8221 cattttggta ttggacactg acataatcgc gatgaattcc cttgatttca atggtttcaa
     8281 ttcctagata ttgaccaatc ccatggatat gatggacaac atagtcccct ttttcaagtt
     8341 cattgtaatc ttttaatctc tctgcatttg aaacatgttg tcttcgaaaa cgacgcttta
     8401 atttcttttg aaaaatctca tgttcagtta tcaataaaat cttttcatct acaaaatgaa
     8461 aaccatgtct gagattaccc tctattaagt ttacagattc tttacagata cttgtcttat
     8521 ctctagaatc caatttaatc tgatattcct ctaacatatc ctccaatgtt ttacttccca
     8581 ttgaattgct agactgcaga ataatggtgt aatccatttt tttatatcgt tcaatttctt
     8641 cttttagaaa agaaaactga ttgaaaaatt cctgcatagg atattgattg aattgataaa
     8701 ttttgtcaaa tttgagattt cctaaaccct tttgaagatt agagaaaaag gtcactggac
     8761 tttgtttttt atagatttgt tcaatatcag aaaaatactg catatcagaa aatgctttac
     8821 tattctgtaa ttcttctgta aagtactgcg ctaattctct ttcaaagact tcatactgat
     8881 tcatcaattt ttgataatca tcaaagaata ttggagtatc tttttcaata taatcaaaga
     8941 cagtccatgt cttatcatag cacaaagata aaaacttccg agagtctgca tgactttgtt
     9001 tttggtgaaa acttgaaaga atttcttcta ggtatgattt caaaataggt gataaagttt
     9061 ttgaaatttg tttttctaaa gctgactgtc ctcgttgata atccttttct ctcaaaagca
     9121 tatcactagc tggaaagata gtgagttctg tcttattttc tttcgataat tgtgtttcta
     9181 cttcaaatga cctgatacca tcaatttcat caccaaaaaa ctcaattcga caaggttcta
     9241 actgggatat ttcaaaaata tctaaaatat ctcctcgaag actaaattcg ccctgagttt
     9301 gtacttgagt aacttttcga tagccatttt cctttaactg atggataaac gcgtgttgat
     9361 catattcttc accaactgag atttttacaa tactatcttt gaatgcattg ggagacggta
     9421 aaatcaatcg acttgctgcg atattacaaa ctaaaatccc tttcttagat gaatcagtca
     9481 aaaaacgcaa ggcttcaacc cgtgaaataa ttttttcctg tgaagacatc aaaaactcca
     9541 ccataggagc atcatctacc aaaaatggat agacgagttc ctcacccaag atagatataa
     9601 gatcactaac aagtccttct gcttctccat aagttgacgt caataacaca atcctatctt
     9661 ctttttctaa actgcttgca attgcaagag ccttagtaga tgttgataaa ccaagtatta
     9721 gttgtctttt cttatctgtt aaattttgat gccatttttt aatctgatca ttttctgaga
     9781 gtaaatctaa taaggtcacc atttatccgt tatacctctg cattgttttc tcaaaatttt
     9841 tctcttgtaa atagtagttt acagaatcgt caactttgtc aacagactgt aaaataccga
     9901 tataatcatc cctgtcaaac ttactcaaaa catgatgaac aactgacata ccatttttag
     9961 gtcttccaat tccaatctta acacggttaa agacctgagt tcctatatgt tgaataatag
    10021 acttgatacc attatgacca cctgctgagc cttttgctct taaacgaatt ttcccaactt
    10081 ccatgtcaag atcatcgtaa atgataagta aatcgtcaat atccaaacca tagtaagtta
    10141 ataaagcatg aactgctttt ccactttcat tcataaaggt cgttggttta accagataaa
    10201 ttttttctcc atttaggaaa aaggatgcta ggtcagcttg aaatatctta tcgtgtgtaa
    10261 aagtgacatt ctgtttcttc gctagttgat caatcaacat aaaaccaaca ttgtgttttg
    10321 tttcaaaata tttatcccct ggatttccca aacctacaag taatttggtc atttattttt
    10381 cctttcaaaa gccaaaaggg ttggaatttt tttccaacct aattgacacc atttattaat
    10441 ttttagacat taaagcggaa ttccatgata tcgccatctt gaacgatata ttcttttcct
    10501 tcttcacgca agcgtccagc ttcttttacg gccttttcag atccgtattt cactagatct
    10561 tcatatgaca tggttactgc acgaataaag cctttttcaa agtctgagtg gataatacca
    10621 gctgcttgag gagccttcat accacgtttg aaagtccaag cgcgaacttc tttttcacca
    10681 gctgtgaagt aagttcccaa tccaagcaag tggtaagctg cacgcgtcaa cttatctaca
    10741 cctgattctg tcaaaccaat ggcttcaaga aactcttttt tatcttcatc atccaattca
    10801 gaaatttctt cctcagcacg cgcagaaata acgactactt cagcattttc tgtcgctgca
    10861 aattcacgaa tttgtttgac atagtcgata gagtcaggtt ctgaaaccac atcctcgtcc
    10921 acattagcta cataaagaac tggtttagtc gtcaaaagga aaagaccttt gacaaccttt
    10981 tgttcctcat ctgtaaattc aatggtacga gctgatttcc cgtcttctag gactggttta
    11041 atcttttgaa gaacattgaa ttctgctact gattctttat ctttttgcgt acgtgccatc
    11101 ttttctacac gcgcatatcg tttgttcact gattctaagt cagcaagaat taattccaga
    11161 ttaattgtat caatatctgc aagtggatct acaaaggcgt cttcacgtcc ttgctcgcgc
    11221 attacatttt catcatcaaa agcacgaact acgtgaacaa tcgcatctac ttcacgaata
    11281 ttggccaaga atttattccc tagcccttct ccttttgaag ctccttttac aatccctgca
    11341 atatctgtaa attcaaatgt tgtgggaact gtctttttag gagttatcat ttcagttagt
    11401 ttttgtaggc gttcatctgg aacttccacc attccaacat ttggatcaat agtcgcaaat
    11461 gggtagtttg ctgcctctgc tcctgctttt gtaattgcat taaatagtgt tgatttacca
    11521 acgtttggca aaccaacgat acctgctgtc aaagccatat ttctcattct ccgttttcat
    11581 ttcaatccct aatattataa cacaaaaagg gaaaacttgc taaaattcct tgatatagct
    11641 atttcccata actgaaataa taattttatg gactttttta ggaacttttt aatttttcaa
    11701 tagctttttc ataaaatgaa gtagcatttt tctgattgtc tttggatagg tggctataaa
    11761 tatccatggt catagaaagt tttgcatgac cgagccgtat ttgtatctct ttgtaaggta
    11821 gtccagcatt gagcaagata ctagcatgag tgtggcggaa ggcgtggaac gtaaaacgag
    11881 ggcatccagc acgttccaaa tgttttacta acctgaaact aagcattcta gcgtctatat
    11941 gcttatcaaa gctattagag aatactttct cataggtcaa ccccatttct ttccctattt
    12001 gggattgtct tgctttatag agccgtagca tgagcaccgt cttattatcc aagtcaatta
    12061 ccctaatact tgatttagtc ttagggccag tgatttcttt gataatattt aacgttttat
    12121 ttacgtctag tgtgccgttt tttaggtcaa tatcagacca tttgagggct aaacactcac
    12181 gaatacgcaa accagtcgct aaaagcgtct tatatagcac cgtatcgtag aaatttttgt
    12241 aagtgtttgg cagctgctcc aggtaagtca agaatttttt taagttatca tcatccagat
    12301 atttcagttt ttgcccttct ttttccttac gacgtggcac gataacatca cgggcagggt
    12361 taaaggggat agcttgcaaa gatacggcat atttaagtat gcgtttgttt agagagtgaa
    12421 ggagcggata ttcttggaat cctttgccta gttgattata gtcttttgcc cattgattga
    12481 cttgcttttg aatgattggg ggcgtcagtt tatccagcct ataatttccg aaagctggaa
    12541 gtagatattt atctattttg aatttggtac ccattaaggt cgatttttta accgtatggc
    12601 agtacgtttc tagccaattc tccaccagtt cggcgtaagt ctttatctcc accgctttat
    12661 atactgtagc ccctcctttt tcaaagtcga tttgagcctg tagcgctttg gctttgagtt
    12721 ctctcttggt tcgccctgat atagtcgtct tgactttctt acctgttacg gtatcgatac
    12781 caaggtagac gctagagcga tagactgtag acccgtcttt tttggtgtat tctgttattt
    12841 tcatgatgat aaacctttct aaaatacatc agcaggcaag ctattattaa aaaggtttta
    12901 gattatggtt tatatcatgt tgagcttacg ggaaagattt tatttgttat tttcttcagc
    12961 taaagctatc tgtacaagtt tttcttttac tttttcagtg agttcctcat agtagagaat
    13021 tgaagaaata atttctttta aaaaattgaa atcgattaac cccattgcta cccataagac
    13081 aatattttcc attgtttcga taaagaaggg aatgaggtaa tcaaggtgat tgattgttaa
    13141 aaatttaata ccgaagacaa tgctacttct cttatttcca tcattgaaca tatgaaattg
    13201 aactgtatta aatactagca ctgtaagttt tgtttcaaag tctggatagt aatcgtcatt
    13261 ctgtaagtgt tcaaatacac taaataccct tcccttatct ttaacaccgt gtaaaccacc
    13321 tattttctca attacttcaa tgtcgtgtag taaaattgct tcttcagcag aaaaataatt
    13381 gattttatcc attatttatc tctcaatctt tcaaaaactt ggcggtgttc atcaatttgt
    13441 tccgaaagtg atttactttg ttcgccaata aatctttcaa aatcttcttc agaaattgga
    13501 cggatatatt ctgctaattt ctcatgtttg gcattcctga aagatagatc cctactagcc
    13561 attttctctc tggcatgcat taaatggggt tcttgcattg ggtgatttgc taatctctga
    13621 attatctcga ttacatcagt attagttagt ttttgatttg aagacttact cttttgttca
    13681 atctcataag caaccccttt ctcaaaacta gcaataacta taagtacctc actatacatt
    13741 gttgcgcgag cattatcatt tttattcaat ttcagtattt ttttatattc tgatgctctt
    13801 tctttaaaga ttgctttgta aatttcattc gttaattgac catatttaaa attacttcca
    13861 gagacatact tatcaatggc atttgtaaat atttttctag cattatcttc ttctaatgca
    13921 gtcgatagat aatttttgtc acgctggttt ataaatttta catggccacc agtcttctca
    13981 gttaacacat taatgacaat atcaagtagg gtatttctta cttgcttagc tatatcacta
    14041 ttggttaaca acatagcaaa attaagcaat gttctgaacg atgagatact taattgtgta
    14101 actttgctac cgacatttgt gtcggtagca aaagcatttt ctttaaattt agctagtttt
    14161 tctccacgta aagtgtgata accattttca gtaagctccg ttttatgagc ttcaacaagt
    14221 ctttcaatag ttcgaatgtc gacttcgaaa aaggtagcta gctgagaatt tgtaaaataa
    14281 aaagtatcct caaagtagaa accaggtact tttaaaatct cttcagcttt ttgtaatgct
    14341 aaagaattat ttaaaatatt ttgtctttct atttgtgagg ttgtcagatc agtcataatt
    14401 tctccttttt gtcgagttaa tttgccaata actcccgata tttcaagagt tttattttat
    14461 tttcgtgtcg ttagagtata ttagaaaatc ttgaactccg cgaatacacg cgcttcagga
    14521 ttgttgaaca ttgtggcgcg tgggttagtc gctgaagtgt tccctgattt cttcagctaa
    14581 atcattcaag cggttctgaa tacctttata gtaatcaaat tcaatggtgt caatgatgtc
    14641 acttttttca gtaaatatct tgttttttgt aacacaaaag ctattatttg tattattgtg
    14701 aacaaggtca tttatctcat tttgaacaga agatattttc ctttgtaagc aatagcctaa
    14761 gatttttcga tcttgaatac ctattttttc aattatttca ttcacttcaa agacaactgc
    14821 cccatagcta tcaattttat tgttaaggct attgataaga ttagaaattt cagaatgcac
    14881 ataggaggta ttgagagctt gctcacgttc aataacgttt attaaacgtg taatatattc
    14941 gttagtaatc atggtgagta cattattata agcgtactcc ctagcttcgc gctgtttgga
    15001 aagtagtaga gcctcattat tttttgagat atctgataaa tcaagtccgt tgaaaatttc
    15061 aacaatacca gggtttatta ttgaagactg aagaacgcga cccaaaacac cctggtcaaa
    15121 tgctattttt cctcgaatgt actccatatt catataatct tttttaaagc taagtatttc
    15181 tttgatttta ttgaagaaca tctcaaaaac cttttctctt tgattattat ctagcaactc
    15241 ttttagtgtg ctggttgaaa ctgtatcaat aaaccgcaga tctaggaaag atttttttac
    15301 gttcaaaaaa tcagctattt tttgtaaatt cccagcggtt ggtaaagatt ttccttttac
    15361 atatcccgta attgtacttt taggaatatc taaagcgtta tgaaggtcaa tttgtctaac
    15421 ccctttttgt tccataagaa ggttgagccg tttagagaag tattctctat tttcaagatc
    15481 ttgaggacta tttttagcca tgactttaac cctttcagtt gtaagttata cattgattat
    15541 aacacaaaat aaaaacaaag tacgaaaata aataaacttt tttctaaaaa cacttgacta
    15601 agtacgaaaa taatagtact attaacttat cacttttgaa aggaattgtt agattatatg
    15661 gaacaatgga cgttgaaagc ctgtagagta aacgctggtt atactttgcg acaggttgct
    15721 aaaaaggtaa ataagaattt tcaaactgtc tccaagtacg aaaaagatag tacatatata
    15781 ccgtttgaac ttttaaaaga attgtctgca atttaccaag ttaaattgga caatattttt
    15841 ttaggagata gtacgaaaaa aatagaacta aataaaagag agttgcaata atgagagtat
    15901 tattttaagt caatggtggc agaaatcaaa ccagacataa caatagatga attattttat
    15961 agctagaaag gagcaaacca atggaactag tctatatgga cggtaaaaaa gagccgtata
    16021 cactgagcag tattgtggca gagtgtgcag aagtcaagca cagacatttg aagattttgc
    16081 taaataaaca ccgagaggac ttcgagagtt tcggaaaggt gcaatttaaa atttcacctt
    16141 cagaaagtgg gcaaaatgta cgggactata ttttaaatga acaacaagca acattgctga
    16201 tcacttactt acgaaataca gaacccgtaa aagagtttaa gaagaaccta gtcaaagcat
    16261 tctttgaaat gcgtgaggaa ctttctaagt ttcgtatgca gagggcgcta gaaaagccaa
    16321 aaagaaaaac cttgcatgac agtattaaaa catgggaggc aaaacccaag cacgcgcata
    16381 gcaccatgaa caacctgtta ctgaaggcag taactgacat gaacgctaag cagttagtaa
    16441 aaagccgtgg gggctataat ggcattgata gcttgaccag tgacgagctg gagcaatacc
    16501 aggcatttga ggatatggta atagccatga ttggcttgaa tatgagttat caggaaatca
    16561 aagctatggc attcagaaat aaaaaaacac gccaaagaag cgtgtgagag caacaaaaaa
    16621 ggcttagcaa taaccacacc gcagagcctt tcacactaac actaaaacga atttaacaaa
    16681 aagcaggcaa gctattatca aagaggtttt agtaaagatt tatacctaga ttatagcata
    16741 tttagggcaa tttgaccata cggagagcgc caactcttta aactggtact ttctcacgct
    16801 ttcaatttgg cgagtctgag cgtgaggcta gtacttacaa gaaaaaactg tataagaaac
    16861 aactcaaaaa gccccacgct cagaagtttg gcgaccgaga gcatgaggct gtaggcaaga
    16921 aaaactgtat aagaaacaac cattcaaaat ccccacactc gccatcgctc aactttgagt
    16981 gtgaggatca gcaggtatag taaaaggtat taaatggccc ttagggcaac tacacaacat
    17041 agaaacagag gtaaaaacat gacagaaaca acatacgaga atttaactag acgtataaac
    17101 agaattagcg cagaaatgca agaaattggc gaaaaaaatg ggcttagtag actttcgtta
    17161 ttggcaagtc agacaaaatt catcaaagaa gaattatccc gtttactttg gattgaactc
    17221 cctgaattga atgacagcca taaaatcgaa gcggtctcta aaagcactac gggaatgttt
    17281 ttccaccctg gtatttttga aatggacgct atgcgacaag cattctttaa acgccaagct
    17341 atgcactttt ttgagaacga agcagagcaa caggcgtata tagaacatgc tgaaaaggag
    17401 tatttagagg ctactataac cttaaaagat attcttttta actctaaaaa tggaactcag
    17461 agagtaaata aaagttgtct tatagagaag tttgaggagg caatgcaatg acactagacc
    17521 tagacaacat gacacaagca gaatttgata aacaaatggc tgaaatcaag gagagaaatc
    17581 caaacatttt tcaactgatt tctgattttt tagatagaaa ggtaacaccc gaagaggtgg
    17641 atgagttttt gaagatggag cgagctgaac aagtggaata tattaagaat tatcaagcga
    17701 gggtataaca tgaatgagct agatataagt aacacacagg ctgctgtctt aatcgtgatt
    17761 ttgattggct tactgcttta tttaaaccac cgagaccgca aaaaaagcgc ccaaattgag
    17821 cgagaaaacc aacagacgat aaaaacacct agcgaggatt taaaccctga ttatgggcga
    17881 tatatccagc ttgcaggagt caacgtatgg ggagggatgg aatgagttac acaatgaatt
    17941 tataccccga tattgaaaaa ataccagatg aaacctattt tactaaagag atttttctag
    18001 caacgtgctt gaataacaca atcagaatag cagtagccag aggagtgcta acatctcaac
    18061 ttttagacaa agaaactaaa gaagttgttt gtaaaacctt ggatacaatc atagaaaatc
    18121 aaaaagctat tttgcaaggg gtagcgagcg gacaaataac ctttgtaaat aaaagcaaag
    18181 gagaggaggg gttggatgag tctatcagag aatgacaagc gagttttaag actaatcaag
    18241 gtaggggctg agaactccat aacagggtca gaaattagcc tgacaaccaa gctaacagaa
    18301 agaactgtac gtgacattat caagcgtcta gtagttaagc acaacatccc tattgtaggg
    18361 gttagatgtg gcgtttttag tgggtacttt attccagcga ataaaggcga gttactagat
    18421 ggcgctaagg ctttttacaa ccaagtacag gaggagagca agcgcctagc ggtgttgatg
    18481 aatagcgacc tagaaagcta caaagaaacc ttgaaggagg tgggcggata tgtttagcct
    18541 aagccgagaa agcgagcaag acctagcgca tggcattctg gaggtagtgg aaagatacct
    18601 ggaagcgcgt gagaaagtac cgccaagatt gaccaagtta ataaatagag ttgaactcaa
    18661 agaggaattg aaaattagtg acaacacgct gaataagtgg gaaagtcagg gtttaagacg
    18721 ctatcaaccg ccggacgatg gtgctagaat aatattttat ttagtggatg acattcgtag
    18781 gtttatgggg gtggagaatg ggtagatata acacacaccc agcgcaaggc ggaggtcatt
    18841 atcatgacat taaattgtat aagcaccgtg gcagatcttt ggaacagttc caagaacaaa
    18901 agctactgaa gaagttaaaa aaaaacgcaa aaaggggcga tagtatgaca atttatgagg
    18961 ctagaggttt ccagagtaat cttgtctatc catttgataa gatggagccg ttccagtaca
    19021 ttgaacgctt taagcctttg gtagtccctg aaagtgctga tccggaggaa tacaaaagaa
    19081 ctcaggcgcc atattgttta agtggtaagg ttatgccgga gaaaaacggg agttacaaac
    19141 gaaacaactc cagtctaatc tatcgggatt tgattttcct tgattatgac gatatacagg
    19201 ggacgactga ggacttcata gaagccgttt ctagcgcttt atttggctac tcttatatct
    19261 tatacccgac tatcaaacat agcatagaaa agccccgttt tcgccttgtg gtgaaatcta
    19321 acaacgtgat gaacgaggca acctataagc aggtagtaaa agagattgct gacaagattg
    19381 ggctaccctt tgacatggcc agtttaacct ggtcacaact ccaagggcta ccagtaacaa
    19441 caggcgaccc agcaacttat caaaagattg tagagcatgg acttgattat ccagtcccca
    19501 aggttgaacc aagagcgaag caaggaacta ctgagcgtta taaacctaga gtaagtggcc
    19561 agaggtcaat gactatgagg atcattgaca cgcttttcaa cggatttgga gacgagggag
    19621 ggcgtaacgt ggcagtgaca cgctttgtgg gattactctt caataagtgg gttgattgtg
    19681 acctagagac cgcctatgaa ctgacaaaga tagccaatag tgtgacagtt gaaccattgc
    19741 ctattgaaga gctagaccgc acttttagca gtatagcacg ggctgagtat agaaagagag
    19801 gttagaacca tagaactaga agaattagca aacctaaaaa gtgaaatcat ggaggtaatg
    19861 gagcaagaac accctcctag aacgatgaag gagcttgaaa atcgtatctt taaagctgga
    19921 gaagaatggc gggcagaaca tactgaaact aaggtaaatg agaccacagg ggacgttacc
    19981 gaaaaggttg ccatgcctca gacattcaca gtagcaaaaa tactgagcga gattgtcaca
    20041 tttactttta tcagcaagag caatatacct gattatagcc tgctctatat ctatgattta
    20101 gacgagggta tctataccgc tagtaatgat ctattcaatc ttttgtgtaa gacctttgac
    20161 gttagaatta aacccagaga gtggccacag attaagttaa tggttagaac attggcaaag
    20221 atacgaaaac ctttagagag tgctaacctt gtacctgtaa agaatggcat tattgaccta
    20281 agaactaagg agctactccc ctttagtcct aagtatgtaa ttacaagtaa gataagcacg
    20341 gcctaccacg cgcctaaacg agtcccaaca gatagagagg gcaaaacttt tgatgattgg
    20401 ctaaactcaa tcgcttgtaa tgatagtgaa ctggtaacac tgttttggca gattatcctt
    20461 gaagctatta accctaacca tacccgaaat aagtttgcta tcttctacgg ggacggtaac
    20521 aatggtaaag ggacattcca gcgcttcctt atcaatctga taggggaaag taatatatca
    20581 gccttgaagc ctgcacagtt cggagaaaag cataacttgg agaccttggt aggtaaggtt
    20641 tgtaatattg gggatgaagc gcctaacgaa tatttaaaaa atccgtctga tttaatgagt
    20701 atcactagtg gcgacactgt tctagtcaat ccaaaaggac gcccagcctt tgaagctact
    20761 ttcaagctat tcaatatctt ttcagggaat tatattccca atggtggcaa caagacaaaa
    20821 ggctggtatc gtagaattat gatcgtccct tttaatgctg actttaacgg ggagaaggaa
    20881 aaaccttgga ttaaaaatga gtttttagca aacaaggaag tcctagagta tgccctctac
    20941 aaagctatca atcaagagcc atttactcac tttatcgaac ctaaagcagt taaaggactc
    21001 ctagaagaat accaggagga taatgactac ttactttcat gggttaagca tgaatacatg
    21061 gaaaaaggtt ggcatgagct ggacgtagta cctgttttta tcgttacaag atcactaaag
    21121 cactatgccg aagatatggg aatacccaaa cccaatgttt acggggctgg taaagaaact
    21181 atcaagcact tacaacagtt gacacctaat cggtattctc taagaaagaa aagagttcct
    21241 tcagaagatt ttgaaaaact agaggcatgg gacgttgaca agataaaaat gcggacacct
    21301 caacactcta tcactaaaca agaataagtg tgacgttctt tttttgctta aacccttgat
    21361 aatactgatt ttcttaaaaa aagtgtgacg ttctcaaaaa agaaggttac accccttgaa
    21421 gccttgatat atctagcttt aggggaatag gtgtgacgtt gtgacattct ttccaactct
    21481 tatatataga gaaaaatgca gtatttatat ataggaacga taaaacaaaa gaacgtcaca
    21541 gggtcacagg ggtggtgaaa cacctagagc ctcaagggtt tgaacgtgtg acgttctttg
    21601 tcacagaagg tcacagaaca cgaaaaatat tacataattt accttaaaat aaagaaatga
    21661 caacaacatg aaagttaaac tatttgaata tactagacga tgggaaaaag aagactttga
    21721 gaaagagatc aatgacttca tggcaactgt tgaagtgctg gacgttaaat tttctggtac
    21781 accatctagt gaatccttta attcggtggc tatcgtattg gtattataca gataacaaaa
    21841 tggggtagat agtaccgacc cccttgtaat ggtgtaacta ctagtgacac ctttaaaaca
    21901 gaaagaggaa aaacaacatg acattaaaaa cattttcgga taaagccaaa acatttactt
    21961 tcacttacga atttaaagac ctagatactg ctatggtagc aggtcacgcg ctactgggat
    22021 atatgactgg gacttatgaa gtaccatcta tttcaataac tcacaaggat aaagggacgc
    22081 ttgtcgctga gtatgtggaa gatcacaagc taaacaagac tttcaagcgt atttgtgaca
    22141 gtttcaaaga ctattacaac caaccagtgg acgatgaagc atttgaagaa cgttataaac
    22201 gggagcgcgt gctccaactc aaagagtaag aggactttga gaacttgctg gaaaaagtaa
    22261 cagactacga gctggaacta ttagactatg ctgatcgctt gctttctgat aagcctatcc
    22321 ctatggactc tatgaccgct tttggtacgt tggaaatgct gggcgatgaa agtattagcc
    22381 tactccaaaa gttggacgta gagggcgaat ataaaggcct tgctggttat acagagcatt
    22441 tgaagtagaa cacaggggag caatcccctt tttgttatca agtcaatagt tttgggtttt
    22501 tccatatagg gggaaataat gaagcggtta gcaatagaaa caatcactaa accaatgaag
    22561 ctgagaggaa tatctaaggg tatagctgag ttggacggtc aacgtttaga gattgatttg
    22621 gataatttaa tgattgattt tggtggagag tcatttgaat tagacagaat agcaggaact
    22681 aagggaggta atagatattt ctttgccctg attgtgggag acggtgcagg ttgctttata
    22741 aacggtattt atattttagt tgcggtactt gtctagatat ccacaagagc accctgaacc
    22801 gtagtaaaac ggattgccaa tactactggg agcttgcact aaaagaagcc agaaaggtag
    22861 aaccagggtg gagtcctaga cgtggtggat atatgtttga tagtttccct gaaagaccaa
    22921 agtatatgaa gcgtgacagg tatcataagc actataagaa gtttttgaag tatattgaaa
    22981 aaggagatag attttggctg aatggtttga gattgtagga caatatgaag tagtgtgcaa
    23041 tttacaaaac aaacaaatac tacatatttg acggtttgaa tgttaaaaaa gctagatata
    23101 tcaaggattt aagtaagtag agtgttccaa aagagggtga ggtaagggtg aggttacata
    23161 taaaaagtac aaggttagta caaggtcaca tacttcaaaa tagcaaggtt ttagcaaggt
    23221 acagggcttt tttctagtga tagaacccta atattaccct aaggtatagc tactttttta
    23281 gaaccataga acggtaaggt tacggtaagg tatcgaagtt ttccaatggt gaggtaaggg
    23341 tgaggtaaga gcaaaaaatg taaaggtttt gtcaaggttg cgtatttaaa agccccaagg
    23401 ttaccacaag gtagagaggt ttaccgaggg ttagaaaagg tgagattttg cttaggtagt
    23461 ggcagtaaat atgcctggaa aatggcaggg ttatgtgtgt tgaactccga gcgaacgccg
    23521 agaaagtggc tatatctccc tccccacgca cttctatgag cttcacaccg tcattgtaca
    23581 ttttttctca cggggaagca tttgaagcta gagcgaacat agagaaaacg aaaaaagcca
    23641 agacactctc tgtctcagct aatagttctc acaaagacta ttatatcata gaggaggccg
    23701 aggcatgaca ccagagcagg taaaagaaaa actagagggc gttaagtgga taaacaaaga
    23761 gatagaaggc ttatatttag agcttgcagc tttagaaagt ggtattatca aaaagcaaga
    23821 actaagcaat accagagtac aaacaagcag ggtaaatacg accgagaata accctataag
    23881 tgttctaaaa ctaaaagagg atacacttca gagaattgag cgacttaatg aagagagaat
    23941 ggaaatatct aggctaatcg ataagctagc caatccgctt gaacgttctg ttctcaggct
    24001 gttctacttg aatgttcttg acgcttggca agttgctgag gaaatagata aatcaaagac
    24061 tgcagtatac attataaggc aaaaagccat agaacactta gcaaatgtgg ggtaataggt
    24121 gagcacaaaa aaacgcctag aacaatctaa gcgctaaaga gtagtggacg gtgtgcctgt
    24181 cccgtcatct catactatga agttgcgtag cgacactatc atctctacct cacttctctt
    24241 tagactatta taccacaaag gagcgaacta atggagctgg ataagtttaa aacgatgatg
    24301 aacgtcagag agcggatgac ctactttcta cgtttccaga ggatggcagg aagtgaaaac
    24361 caagttacga tagatgaaga ggcttggaaa cttgtcttac cttatcggtg ggatttgagc
    24421 ggtgagcatg aaaaagcaat ccgtgagggg ttggaaatat tcgcccaaga catcaacagt
    24481 atagaaaaca aacgagctag aaaatacttt attatccatt actgttacat gagaaagaaa
    24541 acaatgagcg aatgcgtaga aatggcagct actagctcca ctagctacca ccgatataaa
    24601 caaatagccg tcttaaattt tgcgagaatc caccagaacg gagagctaga agtgtataag
    24661 taggcgtttg tggtgttttg ttgagaaatg ttgagattta agtgaggggg gatgacatga
    24721 ttgaagattt tttgattgat ttggagaata tccaattaga ggatatggag atagatttta
    24781 acatggatat agacatcgat ttaaacatag attttgaaat agatgttgac cttgatgatt
    24841 tagatttaac cttactacaa gaattagaag cgtaaatgtt ggcaaatgta ggctgaggct
    24901 tcatattcgt cccctatttt gctttggttt ggactggaca attaaaacac catggataaa
    24961 ctagaagccc tcagaaacga gtctaggggc ttttgtgagg tcataatctt ataaaccacg
    25021 cgcttcatgg tataatatac ctatcagcaa ccagcaataa aaaaagcacg tttaaccgtg
    25081 ctagtttctt gcctgctgaa ctcgtcattt attgcccttt tgtggggctt tttttgtgga
    25141 ctttttgaga atttttaaga acttttaatg atttctaatc aaatgagatt tttcaaaaag
    25201 tcagtaatat caagggttta ggcgctttaa acaagtttaa aagcgtatag attacaatct
    25261 aacacaaaaa gggataaagt gctaaccctc taactaaggg ttctcagtca ataattttat
    25321 tcatttttcg ctcaaaatca tatcgcccca tcatgacaac atgctcacaa ttactgcatt
    25381 ttattttgat atctgctcct acacgtgtaa tttcccaaca attagccttt ttaccagtcg
    25441 acttgattgt acaagcgtgt gattttttca tctcaacaaa atttccaact tgatacatac
    25501 tactctcctt ttctttttcg attatatcat aaaagaggcg agccaggctc aacctctttc
    25561 acttaatttg tacgaactgg tgtaatgagc tgcatgaagt cttcgtcagt atctgctggc
    25621 acaagagtaa atggacgaac agctgagata aagctaatgg tcaccttttc gctatttaaa
    25681 gctttaagag aatcaatcaa gtaagttggg ttgaaactaa tggtcaaatc ttcaccagta
    25741 acctgatcag tatcgatttc ttcgtttact ttaccaactt ctggagagtg aacatgggcg
    25801 ctaacaaccc catccttaat ttcaagtttc acagtaccat tttgagtcgc acttgataaa
    25861 agacgggcac gctccattga ctggcgtaag tttaccacat taaaagtaat agtagtgtta
    25921 aagtctgttg gaatcaagcg atctgtatca ggatagtttc cttctaggag acgagtatag
    25981 aagctaatat tttcgcttct aaagaggatt tggttattgg caaagaaaat ctctacagtt
    26041 tcgatatcat ctgtaaatac cgctgaaaat tcgcgtagag aacggctagg aattacgaca
    26101 tcaaaatcat cactattttt ttcaagagtc aattttttct ggcttaggcg atgagagtct
    26161 gttgcaactg tttttaactc tttgtgttga ctcaatacga agtggacacc tgttaaaatc
    26221 ggacgactct cttgtgtact tgcagcaaag gctgtttcat taataatttt cttgagtaat
    26281 tttgtttcaa gtattaaagg agtgcttgct gaaatttctt ggattcgtgg atattgttcg
    26341 ctatcttttc cttttagggt aatttctgat ttgccactgg ttaaaacaat ttgattttgt
    26401 tcaatttctt taaaatcaag agttacatca ggtaaactag atactacatt gataaagaaa
    26461 gaagcttcaa gaaggatcga acctaaagaa gtaattaaca aaccagcatc ttcatttttt
    26521 tgagaaataa aattttcaat tgaaatttga ccatttgaac caattaaagt aataccttca
    26581 ttggtcacgt caatttttac tgttgataaa ataggaatgg catttttaga actaatagct
    26641 ctcttagtag tatttaatgc ttgtagaaat aaatttttat taattgaaaa atgaatcatg
    26701 gattctcctt tatttatttt tagtattaga aagataatag taataataga gtctgtgaaa
    26761 tctgtggaaa acagccttta aacaagtcat atcaagtttt ttagcttgtt taaaaaatgt
    26821 ggataaaaaa gataaaaaac taaaagttat ccacaaatta tttgattttc tttttgattg
    26881 attcaatttc taaacgtaaa ttatcgtctt gatcaatcaa agattttatt ttggcatggg
    26941 catgaatgac tgtggtatga tcttttcccc caaattcctt cccaattttt ggaagactat
    27001 tatctgttag ttctctagat aaatacatgg ctacttgacg ggccaaaaca atattttgaa
    27061 ggcgtctact tcccttcatt tctttgatac taacaccata aaagttacca acttcagttt
    27121 ggattttatc aattgggatg acgagcattt ggctaacatc ttgtttgcgg gctctaatgg
    27181 cttctgcagc aatatcaata gtgatatcct tgattttttt tactctggca attaaagtga
    27241 tgtcgttgat ggctccctca agatctcgaa catttgaatc aaattgccca gctaggtatt
    27301 ctagagtatc actttggaaa ttgtagccta aatgttccgt tttactttgt aaaatggcaa
    27361 tacgtgtttc aaagtcaggg ggtgtgatag tttgtgtcaa tccccaacta aaacgcgtga
    27421 caagcctctc ctcgagccct tctagatgtt ttggactacg atcactcgtt aggacaatct
    27481 gtttttgctt gtcatgaagg gcgttaaagg tattgaaaaa ttcttcctga gttgcgactt
    27541 tttttccgct gagtgactgg atatcatcga ttaacaaaag atcaagacta cgataggtct
    27601 ttttaaactt ttccatttcc ccaagtctta ggtgatcaag aaagtcatta ataaagcttt
    27661 cggcagggat atatttaaca cgcgcattag gaatattttt tagaatttca tttccaatag
    27721 cgtttaataa gtgagtctta ccaaggcctg gtcctccata gataaaaaga gggttatagg
    27781 tcagagccaa atcttcagag acagctaaag cggctgacac agcccaaaca tttccatccc
    27841 cttgaataaa gttatcaaag gtatactttt cttttaatcc cgtatctgaa taaggaatag
    27901 atactaactt tggactatag ttataaagag ttaaatttgt agcttcttca acttgtgagc
    27961 tagtcgtatc ttgaggtttg gtgaaaatat agtggggagt tatttcagcg tcataaattt
    28021 caaaaccagc tactacaata atatctttta gttgtttttc ccagaccatt tccatttcag
    28081 agcgaggtag aaatatagtg gcaacatttt cctctacctt gatgagttca gcttgaatag
    28141 catagaaatc atacatggat cgagtcagtc tttcttgtgc aaattctaat atacgattcc
    28201 aaaattgttt ttctttcaat cctttctcct cctttactat ttaaaagttt aatactagag
    28261 atattttacc atagatagca agaattttcc acaagctgtg aaaaataatc cacaatgtta
    28321 ccaaacttta tccacaggtt ggggataaaa gaagaaatta ttgatttatt aagcttttta
    28381 tcgaaaaaca tagtggataa ccttgtgaga taaaaaaata aaagaacagc cttatttcag
    28441 gctgttgata attctactat attcttcttg atttgaaaaa gaaataatga tttttccact
    28501 gtctttttta gatagtttaa tttctacatc taatccgagt agttttctta actgtttttc
    28561 ttcattttgt atgaaatgat tagttttttg ctgtttcttt tgttttttct ctgtcagaag
    28621 agcttctaat ttccttacag aaatatcttc ttctataatc cgttgaaaga aatagtcttg
    28681 ttgttcctta tttaacccaa ctagggaacg cgcatgggct tgtgatagtt tgccattttc
    28741 tacttctgaa agaatctgtt ctggcaagga aagtaaacga atggagttgc tgatatatgg
    28801 acgagacttg cccatcttat ctgcaatttc agcatgggtg aatcctttct ctacgagaga
    28861 ttcataggcg cgtgcttctt ctattgggtt taaattttct ctctgtaaat tttcaataat
    28921 ggactggacc atcatctctt ggtctgaaat ctgtttaaca acagctggga tagaccgtag
    28981 accagctaaa agtgaagccc gatagcgtct ctctcctgca aggatttcat aaccaataac
    29041 aggagattga cgaacaataa tcggttgaat gaccccattt tctttgatag actgtgctag
    29101 ttcatctagt ttttctctat caaattcttt tcggggttga tagggatttt tttgtatatc
    29161 tgtgatagaa atcatttcaa atttttccat gattctacac taacacatct tttctcttat
    29221 gtaaagcttt ctttacatag atgtcaatta agattctaaa tcacctgaac tcttgttaag
    29281 tttgatagag gtagtttctt ctttcccgtt acgatagtag gttatcttaa tggtgtctcc
    29341 gatagaatgg ttgtaaagag cactttgtaa gtctgttgat gaagcaatct ctttgtcatc
    29401 tacttttgta attacatcgt atttttcaag gtgaccattg gcaggcatat tactttgtac
    29461 cgaacgaaca actacaccag atgtaacatt acttggaata ttgagtcttc tgatgtcgct
    29521 tgtactcaca ttagataaat taaccatctg gattcccaaa gctggacgcg tcacttttcc
    29581 gtttttttct aactgttcaa taatattgat agcatcattt gcaggaattg cgaaaccaag
    29641 accttctaca gatgttcctc catttgtagc aattttactt gaggtaattc cgataacctg
    29701 cccttgaata ttgatcagtg ggccgccaga gttacctggg ttaatagcag tatcagtttg
    29761 gatggctttt gtagaaatag cttgtccatc ttccgatttt aaggatacat ttctattgag
    29821 actggatacg ataccttgag tgacagtatt tgcatattca gaacctaacg ggctaccgat
    29881 ggcaatagca gtttctccta cagttaactt actagaatca ccaaactcag ctactgttgt
    29941 cactttttct gaagagattt ttacgacagc aatatcagag aaagtgtcag ctccgacaat
    30001 ttctccaggt actttagtcc catctgacaa tcgaatatct actttgctgg cgccatttat
    30061 aacgtgattg ttggtgacga tgtaagcttc tttatcattc tttttataaa taactccaga
    30121 tccttcacta gagattcgct gagaatctgt gtcagtatca tcattgccaa atacgctatt
    30181 ttgtctgttt gccgaataag taataacaga aacaacagca tcttttactt tgttaacagc
    30241 ctgtgttgtt gaattttcgt tcttataggc agtttgtgta atagtactat tgttgttaga
    30301 gttgtttaca ctactttttt gagttagttg agttattgaa aaactaccca aggctccact
    30361 aaaaaagcta atgacgataa cgactaataa ttgaaaccat tttttgtaaa atgtttttag
    30421 atgtttcata tttgcctcca tatgtttgaa ttactgaaag tataaactga ctagcttaat
    30481 tataacttaa acacaaaagt tttacacaaa ctgtggataa ctcttttgaa ac
//
LOCUS       DAVLHC010000025        30060 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.025, whole genome shotgun sequence.
ACCESSION   DAVLHC010000025 DAVLHC010000000
VERSION     DAVLHC010000025.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 30060)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 30060)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..30060
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.025"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            463..1506
                     /locus_tag="VXE25_001243"
     CDS             463..1506
                     /locus_tag="VXE25_001243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR00341 family protein"
                     /protein_id="HEV0771707.1"
                     /translation="MTNNKLYSLIEFRNKIYEELELSRSDLAILLCAMLIASIGLNMD
                     STPVIIGAMLISPLMTPILGVGLSLAIFDFKLLRKSFKILAIQILASLIASTLYFYLS
                     PISYASSEIVARTSPTIWDVLIAFVGGIAGIIGARKKETNNIVPGVAIATALMPPLCT
                     VGYAIASANLKFIIGSSYLFLINCSFIVIATYIGVRLMMVKKHYFKDNEEDSKMRRIL
                     LLVAVLLMIPSFISATTLVRETLKKESLKKFISEQFQGYNILKKTYSKKTHTLKLTIS
                     GNYLTEEELDMISSKRGDYGLSDVSVQVSQLSDSEQLSKEELVEYFFQYIKDKEAKEK
                     EKANKFDTESEEQ"
     gene            1674..3761
                     /gene="topA"
                     /locus_tag="VXE25_001244"
     CDS             1674..3761
                     /gene="topA"
                     /locus_tag="VXE25_001244"
                     /EC_number="5.6.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000179642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I DNA topoisomerase"
                     /protein_id="HEV0771708.1"
                     /translation="MATATKKKKSTVKKNLVIVESPAKAKTIEKYLGRNYKVLASVGH
                     IRDLKKSSMSVDIENNYEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAIS
                     WHLAHILNLDENDANRVVFNEITKDAVKNAFKEPRKIDMDLVDAQQARRILDRLVGYS
                     ISPILWKKVKKGLSAGRVQSIALKLIIDRENEINAFQPEEYWTVDAVFKKGTKQFHAS
                     FYGVDGKKMKLTSNNEVKEVLSRLTSKDFSVDQVDKKERKRNAPLPYTTSSMQMDAAN
                     KINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAASFITDRFGS
                     KYSKHGSKVKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQM
                     TAAVFDTMAVKLSQNGVQFAANGSQVKFDGYLAIYNDSDKNKMLPDMAVGDVVKQVNS
                     KPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVRLAAKRFEPTEL
                     GEIVNKLIVEYFPDIVNVTFTAEMEGKLDDVEVGKEQWRRVIDAFYKPFSKEVAKAEE
                     EMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFYACSNFPDCRHTQAIVKEIGVECPS
                     CHQGQIIERKTKRNRLFYGCNRYPECEFTSWDKPVGRDCPKCGNFLMEKKVRGGGKQV
                     VCSKGDYEEEKIK"
     gene            3867..4226
                     /locus_tag="VXE25_001245"
     CDS             3867..4226
                     /locus_tag="VXE25_001245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YbaN family protein"
                     /protein_id="HEV0771709.1"
                     /translation="MRLIYLIIGFLSLALAIVGVVLPLLPTTPFLLLSIACFSRSSKR
                     FEDWLYHTKLYQTYVADFRETKSITRERKKKIIVSIYVLMGISIYFAPLLPVKIGLGA
                     LTIFITYYLFKVIPDKE"
     gene            4319..4951
                     /locus_tag="VXE25_001246"
     CDS             4319..4951
                     /locus_tag="VXE25_001246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000638771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="copper homeostasis protein CutC"
                     /protein_id="HEV0771710.1"
                     /translation="MIYEFCAENVTLLEKAMQAGARRIELCDNLAVGGTTPSYGVTKA
                     AVELAANYDTTIMTMIRPRGGDFVYNDLEIAIMLEDIRLTAQAGSQGVVFGTLTADKK
                     LDKPNLEKLIAASKGMEIVFHMAFDELSDEDQPEAIDWLSQAGVTRILTRAGVSGDSL
                     EKRFVHYHRILEYAKGKIEILPGGGIDLENRQTFIDQVGVTQLHGTKVVF"
     gene            4995..5651
                     /locus_tag="VXE25_001247"
     CDS             4995..5651
                     /locus_tag="VXE25_001247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000461593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MmcQ/YjbR family DNA-binding protein"
                     /protein_id="HEV0771711.1"
                     /translation="MFEIFKSYQFNQEKAHDYGFIENSEVWTYSCQILQGDFVMTVSI
                     TADNVNFQVFDQETGDLYPHVHMESMRGSFVGNVREACLEILYQIRKACFDVQDFICH
                     QTKRIMTQVQEKCGNQLEYLWEKSPDTAVLRHEGNQKWYAVLMKISWNKLEKGREGQV
                     EAVNLKHDQVANLLSQKGIYPAFHMSKRYWISVSLDDTLSDEEVLELIEKSWNLTSKK
                     "
     gene            5670..6764
                     /locus_tag="VXE25_001248"
     CDS             5670..6764
                     /locus_tag="VXE25_001248"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001010962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-isopropylmalate synthase"
                     /protein_id="HEV0771712.1"
                     /translation="MNFQLAKYSLLKKFSENIGFTTPEEYGAIFKYLIENVKTDRQII
                     YSPHCHDDLGIAVANSLAAVKNGAGRVEETINGIRERAGNAALEEIAVALNIRQDYYQ
                     VETSIVLTETINTSEMVSRFPGIPVPKNKAVVGGNTFSHESGIHQDGVLKNPLTYENI
                     TPELVGVKIPLGKLSGRHAFVEKLRELALDFTEEDIKPLFAKFKALADKKQEITDADI
                     RALVAGTMVENPEGFHFDDLQLQTHADNDIEALVSLANMDGEKVEFNATGQGSVEAIF
                     NAIDKFFNQSVRLVSYTIDAITDGIDAQDRVLVTVENRDTETIFNATGLDFDVLKASA
                     IVYINANTFVQKENAGEMGRSVSYHDMPSV"
     gene            6776..7812
                     /gene="leuB"
                     /locus_tag="VXE25_001249"
                     /pseudo
     CDS             6776..7812
                     /gene="leuB"
                     /locus_tag="VXE25_001249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399454.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="3-isopropylmalate dehydrogenase"
     gene            7809..8078
                     /locus_tag="VXE25_001250"
     CDS             7809..8078
                     /locus_tag="VXE25_001250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000762418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1294 domain-containing protein"
                     /protein_id="HEV0771713.1"
                     /translation="MKLDEKITLVLLIWNVIIFLIYGIDKFKARRRAWRIQEKILLIL
                     ALTCGGFGAWLAGITFHHKTRKWYFKTVWFLGMVTTLVALYFIWR"
     gene            8082..8441
                     /gene="leuD"
                     /locus_tag="VXE25_001251"
     CDS             8082..8441
                     /gene="leuD"
                     /locus_tag="VXE25_001251"
                     /EC_number="4.2.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-isopropylmalate dehydratase small subunit"
                     /protein_id="HEV0771714.1"
                     /translation="MAGSSREHAAWVLADYGFKVVIAGSFGDIHYNNELNNGLLPIVQ
                     PREVREKLAQLKPTDQVTVDLEQQKIISPVEEFTFEIDSEWKHKLLNSLDDIGITLQY
                     EELIAAYEKQRPAYWQD"
     gene            8603..9171
                     /locus_tag="VXE25_001252"
                     /pseudo
     CDS             8603..9171
                     /locus_tag="VXE25_001252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019771122.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="translation factor (SUA5)"
     gene            9265..9330
                     /locus_tag="VXE25_001253"
                     /pseudo
     CDS             9265..9330
                     /locus_tag="VXE25_001253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001849983.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="translation factor (SUA5)"
     gene            9493..11424
                     /locus_tag="VXE25_001254"
     CDS             9493..11424
                     /locus_tag="VXE25_001254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001042398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="McrB family protein"
                     /protein_id="HEV0771715.1"
                     /translation="MNKRKVSLEDFYKWYSLNKEELLNKATVGEKFNDKLKEEFLQEW
                     PLDRILTMSIDEYVIGKGQQNKSLCYALEKGKYKNLFLGISGGSASKFGIYWNKKTNK
                     YKDQANNEISELDQRFSKLKSDLYEIIKEGIRFNFENPIFDMKRSTNEFIGRSAMVTK
                     LLCIYSEGDPFFGVNINSQKEFWNHFVSQTNQGGPYLQNHKIIELVSKTYPELEPSKV
                     GTMLFEYSKLFMENKEDNSTMDSSNNFRHQLTQSLLKSPNLILRGAPGTGKTYLAKEI
                     AKELTDGNEDQIGFVQFHPSYDYTDFVEGLRPVSNGDGAIEFRLQDGIFKDFCQKAKE
                     TQLIGGQDNFDEAWDSYLEYINVAEEKEYITKTSYLSVNSRQNLSVNYDSGVPGWSLP
                     SKYVYELYKDKNYNKQEYYKSGGKTVLETLRKRFGLKDYVSPTEIDTDKKFVFIIDEI
                     NRGEISKIFGELFFSIGPGYRGEKGSVSTQYANLHETDEKFYIPENVYIIGTMNDIDR
                     SVDTFDFAMRRRFRFVEVTAEGQVGMLDKELNIHAEEAKIRLRNLNAAIENVQELNSH
                     YHIGPSYFLKLKDVDFDYELLWSDYIKPLLEDYLRGSYDEVETLETLKKAFELTNNEQ
                     KDQAVADDNEGDENDDADY"
     gene            11411..12727
                     /locus_tag="VXE25_001255"
     CDS             11411..12727
                     /locus_tag="VXE25_001255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001223073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="McrC family protein"
                     /protein_id="HEV0771716.1"
                     /translation="MRITDNQHKIIKEKFVEEYPKLSNLLLDRTLESLSQDERIFIFP
                     NDLTHTPDLDKDQKIFETVNQKIKTGNVIGFLGYGQERLTISSRFSDESNDHFLHYLL
                     NKVLHINLTSLDVALSREERLYQLLVYLFPKYLQAAIRKGLYKEYHRFSHNDSNVKGV
                     IDVRSHLKKNLPFTGNIAYATREFTYDNPLMQLVRHTIEYIKNQKSIGQGVLDNLSTS
                     RENVSEIVRVTPSYKLADRAKIIRGNQSKPIRHAYFHEYRNLQELCLMILNQEKHGLG
                     YQDQKIYGILFDVAWLWEEYVYTLLPKGFVHPRNKDKTDGISVFSVGKRKVYPDFYDR
                     ERKIVLDAKYKKLELTEKGINREDLFQLISYSYILKAEKAGLIFPSMEQSVNSEIGKV
                     AGYGAQLKEWSIRIPQNASFYSTFCKMMENSEENFKAIIDEEVGRK"
     gene            12902..13888
                     /gene="guaC"
                     /locus_tag="VXE25_001256"
     CDS             12902..13888
                     /gene="guaC"
                     /locus_tag="VXE25_001256"
                     /EC_number="1.7.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007516839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GMP reductase"
                     /protein_id="HEV0771717.1"
                     /translation="MLNEFPIFDYEDIQLIPNKCVIKSRAEADTSVTLGNHTFKLPVV
                     PANMQTILDENVAEQLAKGGYFYIMHRFDEAGRIPFIKRMHNQGLIASISVGVKDYEY
                     DFVRQLKTDAPEYITIDIAHGHADSVISMIQHIKKELPDTFVIAGNVGTPEAVRELEN
                     AGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIA
                     KSIRFGASMIMIGSLFAGHIESPGKTIEVDGEQFKEYYGSASQYQKGAYKNVEGKRIL
                     LPTKGHLQDTLTEMEQDLQSAISYAGGRQVADLKHVDYVIVKNSIWNGDASH"
     gene            13952..14023
                     /locus_tag="VXE25_001257"
     tRNA            13952..14023
                     /locus_tag="VXE25_001257"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:13985..13987,aa:Arg,seq:ccg)
     gene            14206..14904
                     /locus_tag="VXE25_001258"
     CDS             14206..14904
                     /locus_tag="VXE25_001258"
                     /EC_number="3.1.26.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease III"
                     /protein_id="HEV0771718.1"
                     /translation="MKELQTVLKNHFAIEFTDKKLLETAFTHTSYANEHRLLKISHNE
                     RLEFLGDAVLQLLISEYLYKKYPKKPEGDLSKLRAMIVREESLAGFARDCQFDQFIKL
                     GKGEEKSGGRNRDTILGDAFEAFLGALLLDKDVAKVKEFIYQVMIPKVEAGEFEMITD
                     YKTHLQELLQVNGDVAIRYQVISETGPAHDKVFDVEVLVEGKSIGQGQGRSKKLAEQE
                     AAKNAVEKGLDSCI"
     gene            14895..18434
                     /gene="smc"
                     /locus_tag="VXE25_001259"
     CDS             14895..18434
                     /gene="smc"
                     /locus_tag="VXE25_001259"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000280891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosome segregation protein SMC"
                     /protein_id="HEV0771719.1"
                     /translation="MYLKEIEIQGFKSFADKTKVVFDQGVTAVVGPNGSGKSNITESL
                     RWALGESSVKSLRGGKMPDVIFAGTESRKPLNYASVVVTLDNHDGFIKDAGQEIRVER
                     HIYRSGDSEYKIDGKKVRLRDIHDLFLDTGLGRDSFSIISQGKVEEIFNSKSEERRAI
                     FEEAAGVLKYKTRRKETESKLQQTQDNLDRLEDIIYELDNQIKPLEKQAENARKFLDL
                     EGQRKAIYLDVLVAQIKENKAELESTEEELAQVQELLMSYYQKREKLEEENQTLKKQR
                     QDLQAEMAKDQGSLMDLTSLISDLERKLALSKLESEQVALNQQEAQARLAALEDKRNS
                     LSKEKSDKESSLALLEGNLVQNNQKLNRLEAELLAFSDDPDQMIELLRERFVALLQEE
                     ADVSNQLTRIENELENSRQLSQKQADQLEKLKEQLAIAKEKASQQKEELETAKEQVQK
                     LLADYQAIAKEQEEQKTSYQAQQSQLFDRLDNLKNKQARAQSLENILRNHSNFYAGVK
                     SVLQEKDRLGGIIGAVSEHLTFDMHYQTALEIALGASSQHIIVEDEESATKAIDFLKR
                     NRAGRATFLPLTTIKARTISSQNQDAITVSPGFLGMADELVTFDTRLEAIFKNLLATT
                     AIFDAVEHARAAARQVRYQVRMVTLDGTELRTGGSYAGGANRQNNSIFIKPELEQLQK
                     EIAADEASLRSEEAALKTLQDQMATLTERLEVIKSQGEQARIQEQGLSLAYQQTSQQV
                     EELETLWKLQEEEIDRLSEGDWQADKEKCQDRLAAIASDKQNLEAEIEEIKSNKNAIQ
                     ERYQNLQEELAQARLLKTELQGQKRYEVADIERLGKELDNLDFEQEEIQRLLQEKVDN
                     LEKVDTELLSQQAEEAKTQKTNLQQGLIRKQFELDDIEGQLDDIASHLDQARQQNEEW
                     IRKQTRAEAKKEKVSERLRYLQSQLTDQYQISYTEALEKAHELENLNLAEQEVQDLEK
                     AIRSLGPVNIEAIDQYEEVHNRLDFLNSQRDDILSAKNLLLETITEMNDEVKDRFKST
                     FEAIRESFKVTFKQMFGGGQADLILTEGDLLTAGVEISVQPPGKKIQSLNLMSGGEKA
                     LSALALLFSIIRVKTIPFVILDEVEAALDEANVKRFGDYLNRFDKDSQFIVVTHRKGT
                     MAAADSIYGVTMQESGVSKIVSVKLKDLESIEG"
     gene            18431..19225
                     /locus_tag="VXE25_001260"
     CDS             18431..19225
                     /locus_tag="VXE25_001260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000153012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEV0771720.1"
                     /translation="MTIKLVATDMDGTFLDGNGRFDMDRLKSLLASYKEKGIYFAVAS
                     GRGFLSLEKLFADVRDDIIFIAENGSLVEYRGQDLYEATMSREFYLTTFEKLKTSPYV
                     DINKLLLTGKKGAYVLDTVDETYLKVSQHYNENIQKVASLEDITDDIFKFTTNFTEET
                     LEAGEAWVNENVPGVKAMTTGFESIDIVLDYVDKGVAIVELAKKLGIIMDQVMAFGDN
                     LNDLHMMQVVGHPVAPENARPEILELAKTVIGHHKDQSVIAYMEGL"
     gene            19225..20043
                     /locus_tag="VXE25_001261"
     CDS             19225..20043
                     /locus_tag="VXE25_001261"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEV0771721.1"
                     /translation="MADIKLIALDLDGTLLTTDKRLTDRTKATLKAASDRGIKVVLTT
                     GRPLKAMDFFLHELGTDGHEDEYTITFNGGLVQKNTGEILDKTVFSYDDVARLYEETE
                     KLSLPLDAISEGTVYQIQSDQESLYAKFNPALTFVPVDFEDLSSQMTYNKCVTAFAQE
                     PLDAAIQKISPELFDQYEIFKSREMLLEWSPKNVHKATGLAKLISHLGIDQSQVMACG
                     DEANDLSMIEWAGLGVAMQNAVPEVKAAANVVTPMTNDEEAVAWAIEEYVLKEN"
     gene            20047..21267
                     /gene="ftsY"
                     /locus_tag="VXE25_001262"
     CDS             20047..21267
                     /gene="ftsY"
                     /locus_tag="VXE25_001262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000522312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal recognition particle-docking protein
                     FtsY"
                     /protein_id="HEV0771722.1"
                     /translation="MGLFDRLFGKKEEPKIEEVVKEALENLDLSEDVDPTFTEVEEVS
                     QEEAVLEESQDSEPAVGVSQEEIEELPEEEKLEHEGTIEENNSEVLEAERPQAEETVQ
                     EKYDRSLKKTRTGFGARLNAFFANFRSVDEEFFEELEELLIMSDVGVQVASNLTEELR
                     YEAKLENAKKPDALRRVIIEKLVELYEKDGSYDESIHFQDNLTVMLFVGVNGVGKTTS
                     IGKLAHRYKRTGKKVMLVAADTFRAGAVAQLAEWGRRVDVPVVTGPEKADPASVVFDG
                     MERAVAEGIDILMIDTAGRLQNKDNLMAELEKIGRIIKRVVPEAPHETFLALDASTGQ
                     NALVQAKEFSKITPLTGIVLTKIDGTARGGVVLAIREELNIPVKLIGFGEKIDDIGEF
                     NSENFMKGLLEGLI"
     gene            complement(21311..22798)
                     /locus_tag="VXE25_001263"
     CDS             complement(21311..22798)
                     /locus_tag="VXE25_001263"
                     /EC_number="1.1.1.49"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000096131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-6-phosphate dehydrogenase"
                     /protein_id="HEV0771723.1"
                     /translation="MSSKVIVTIFGASGDLAKRKLYPSLFRLYQSGNLSKHFAVIGTA
                     RRPWSKEYFESVVVESILDLADSTEQAQEFASHFYYQSHDVNDSEHYIALRQLQAELN
                     EKYQAEHNKLFFLSMAPQFFGTIAKHLKSENIVDGKGFERLIVEKPFGTDYATASKLN
                     DELLATFDEEQIFRIDHYLGKEMIQSIFAVRFANLIFENVWNKDFIDNVQITFAERLG
                     VEERGGYYDQSGALRDMVQNHTLQLLSLLAMDKPASFTKDEIRAEKIKVFKNLYHPTD
                     EELKEHFIRGQYRSGKIDGMKYISYRSEPNVNPESTTETFTSGAFFVDSDRFRGVPFF
                     FRTGKRLTEKGTHVNIVFKQMDSIFGEPLAPNILTIYIQPTEGFSLSLNGKQVGEEFN
                     LAPNSLDYRTDATATGASPEPYEKLIYDVLNNNSTNFSHWDEVGASWKLIDRIEELWA
                     ENGAPLHDYKAGSMGPQASFDLLEKFDAKWTWQPDIAYRQDGRFE"
     gene            complement(22947..23687)
                     /locus_tag="VXE25_001264"
     CDS             complement(22947..23687)
                     /locus_tag="VXE25_001264"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254183.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEV0771724.1"
                     /translation="MAKLKIDVNDLHKYYGKNEVLKGITTKFYEGDVVCIIGPSGSGK
                     STFLRSLNLLEEVTSGHITVNGYDLTEKTTNVDHVRENIGMVFQHFNLFPHMSVLDNI
                     TFAPIEHKLMTKEEAEELGMELLEKVGLADKANANPDSLSGGQKQRVAIARGLAMNPD
                     IMLFDEPTSALDPEMVGDVLNVMKELAEQGMTMIIVTHEMGFARQVANRVIFTADGEF
                     LEDGTPDQIFDNPQHPRLKEFLDKVLNV"
     gene            complement(23687..25852)
                     /locus_tag="VXE25_001265"
     CDS             complement(23687..25852)
                     /locus_tag="VXE25_001265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding
                     protein/permease"
                     /protein_id="HEV0771725.1"
                     /translation="MKKKFLAFLLILFPIFSLGIAKAETIKIVSDTAYAPFEFKDSDQ
                     TYKGIDVDIINKVAEIKGWNIQMSYPGFDAAVNAVQAGQADAIMAGMTKTKEREKVFT
                     MSDTYYDTKVVIATTKSHKISKYDQLTGKTVGVKNGTAAQRFLETIKDKYGFTIKTFD
                     TGDLMNNSLSAGAIDAMMDDKPVIEYAINQGQDLHIEMDGEAVGSFAFGVKKGSKYEH
                     LVTEFNQALAEMKKDGSLDKIIKKWTASSSSAVPTTTTLAGLKAIPVKAKYIIASDSS
                     FAPFVFQNSSNQYTGIDMELIKAIAKDQGFEIEITNPGFDAAISAVQAGQADGIIAGM
                     SVTDARKATFDFSESYYTANTILGVKESSNIASYEDLKGKTVGVKNGTASQTFLTENQ
                     SKYGYKIKTFADGSSMYDSLNTGAIDAVMDDEPVLKYSISQGQKLKTPISGTPIGETA
                     FAVKKGANPELIEMFNNGLANLKANGEFQKILDKYLASESSTASTSTVDETTLWGLLQ
                     NNYKQLLSGLGITLALALISFAIAIVIGIIFGMFSVSPYKSLRVISEIFVDVIRGIPL
                     MILAAFIFWGIPNFIESITGQQSPINDFVAGTIALSLNAAAYIAEIVRGGIQAVPVGQ
                     MEASRSLGISYGKTMRKIILPQSTKLMLPNFVNQFVIALKDTTIVSAIGLVELFQTGK
                     IIIARNYQSFKMYAILAIFYLVIITLLTRLAKRLEKRIR"
     gene            26025..26978
                     /locus_tag="VXE25_001266"
     CDS             26025..26978
                     /locus_tag="VXE25_001266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000792120.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEV0771726.1"
                     /translation="MKNKRIFKDFQASKMNLNIYTSPLLAFVFVFIGEFVAYTLYGIS
                     LLALIGLARNFGEAGQNLASYLQTLHQSLTDKTSDFRLILGLLAFGFILNTVFRWTRK
                     VEKRPIRTLGFYRENFLSNLLKGFSLGLALFLLTLLGLVVLGQYRLESIHLNPYSLAF
                     VVFTIPFWILQGTAEEVVARAWLLPQLASRTNLKLAILISSLFFTLLHMGNSGLTPLS
                     LVNLFLFGVAMALYLLKTDTVWGVAGIHGAWNFAQGNLFGILVSGQPSGTSLMTFLPQ
                     GNQDWLSGGSFGIEGSIMTSLVLLLLIVYLANKLKKENERM"
     gene            27055..29043
                     /gene="uvrB"
                     /locus_tag="VXE25_001267"
     CDS             27055..29043
                     /gene="uvrB"
                     /locus_tag="VXE25_001267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit B"
                     /protein_id="HEV0771727.1"
                     /translation="MINHITDNQFKLVSKYQPSGDQPQAIEQLVDNIEGGEKAQILMG
                     ATGTGKTYTMSQVISKVNKPTLVIAHNKTLAGQLYGEFKEFFPENAVEYFVSYYDYYQ
                     PEAYVPSSDTYIEKDSSVNDEIDKLRHSATSALLERNDVIVVASVSCIYGLGSPKEYA
                     DSVVSLRPGLEISRDKLLNDLVDIQFERNDIDFQRGRFRVRGDVVEIFPASRDEHAFR
                     VEFFGDEIDRIREVEALTGQVLGEVDHLAIFPATHFVTNDDHMEVAIAKIQAELEEQL
                     AVFEKEGKLLEAQRLKQRTEYDIEMLREMGYTNGVENYSRHMDGRSEGEPPYTLLDFF
                     PDDFLIMIDESHMTMGQIKGMYNGDRSRKEMLVNYGFRLPSALDNRPLRREEFESHVH
                     QIVYVSATPGDYENEQTETVIEQIIRPTGLLDPEVEVRPTMGQIDDLLGEINARVEKN
                     ERTFITTLTKKMAEDLTDYFKEMGIKVKYMHSDIKTLERTEIIRDLRLGVFDVLVGIN
                     LLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNSEGHVIMYADTVTQSMQ
                     RAIDETARRRKIQMTYNEEHDIVPQTIKKEIRDLIAVTKAVAKEEDKEVDINSLNKQE
                     RKELVKKLEKQMQEAVEVLDFELAAQIRDMMLEVKVLD"
     gene            29053..29616
                     /locus_tag="VXE25_001268"
     CDS             29053..29616
                     /locus_tag="VXE25_001268"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000639844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0771728.1"
                     /translation="MIYLRKLKREDLMSLWEMAYSQLNPVWKQYDAPYYDDYQYFSNF
                     KEFELQKSESILSNSNRLGIFVDDKLVGTVSRYWVCKQTRWMELGIGIYDKKFWNTGI
                     GKVAMLQWIDRTFQDYLELEHLGLTTWSGNLGMMKLAEKLRMKKEAHIPKVRYYQGKY
                     FDSIKYGILREDWEKINDGYYQINGNS"
     gene            29582..>30060
                     /locus_tag="VXE25_001269"
     CDS             29582..>30060
                     /locus_tag="VXE25_001269"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254187.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0771729.1"
                     /translation="MTVIIKSMETPEEIEGKSLVHWQTWREAYDDLLPAEFQETMTLE
                     RCRFFSQKYPENTLIAIDDLKVVGFISYGSFRDETIQAGEIIALYVLKDYYGKGIAQK
                     LVKVALTALNHFSEIFLWVLKDNKRAIAFYQKMGFTFDGQEKILELGKPIKEKRMVF"
BASE COUNT         9315 a         5296 c         6686 g         8763 t
ORIGIN      
        1 acactataat ttagtgtaat tgagaaagga gaaatgattg tgattgatgt tggctaggtt
       61 atgttcaatg attcctaccg tctcaaatct tgtcagtaag gaaaaataaa ttcttcaaaa
      121 gtagagatta caaggcttgt ttaagaaaga attcaaagac cttgacaaat aaaaataaaa
      181 tggttattat aagagatggt ctaaaataga tggtgatact tttcgaaaat ctttttacgt
      241 cagctcagct ttgccttgct gtgttttgag caagctacgg ttagcttccg agtttgattt
      301 tcatttacta gaaatgaaac tgatgagaga tatcagtaga catttgagtc aggatattat
      361 ggaaaatgat aaaaagagct cgtgagattg gcatatcaga ctactaaagt attgagtttg
      421 ttaggatttt agcgactagt tagctgggaa aggaagatat ttgtgacaaa taataaactg
      481 tattcgttga tagaatttag aaataaaata tatgaagaat tagaactttc cagaagtgat
      541 ttagcgattt tactatgtgc catgcttatc gcctctatcg gattaaatat ggattcgact
      601 cccgtgatta ttggagccat gttaatctct cctttgatga cacctattct gggagtgggg
      661 ctctctctag ctatatttga ttttaaattg ttaagaaaat cttttaaaat attagctatt
      721 caaattcttg ccagtctaat agcttcaaca ctttattttt atctttctcc catttcgtat
      781 gctagttcgg agattgttgc tagaacctct ccgactattt gggatgttct cattgctttt
      841 gtaggaggga tagcaggtat tattggtgct aggaaaaaag agaccaataa tattgttcct
      901 ggtgttgcta ttgcaaccgc cttgatgcct cctctttgta cagtaggtta tgctattgct
      961 tctgctaatc taaaatttat cataggctcc tcttacctat tcctcatcaa ttgtagcttt
     1021 attgtcattg cgacttatat aggtgttagg ttgatgatgg ttaagaaaca ttattttaaa
     1081 gataatgaag aagactctaa aatgcgtagg attttgcttc tagttgctgt tttgctgatg
     1141 attccgagtt tcatctctgc aacgacttta gtgagagaaa cgttgaaaaa agagtccctt
     1201 aagaaattta tatcagagca gtttcagggg tataatattt tgaaaaaaac ctattctaaa
     1261 aagactcata ccctaaagct aaccatttca ggaaattatt tgacagaaga agaactcgat
     1321 atgatttcaa gtaagagagg tgactatggt ttaagtgatg tttctgttca agtttcacaa
     1381 ttgtctgatt cagaacaact tagtaaggaa gagctggtgg agtatttctt ccagtatatc
     1441 aaggataagg aagcaaaaga aaaggagaaa gccaataaat ttgatacaga gtctgaggag
     1501 caataatttc ttgagaatag ctggtttctc tcgtgagtct tctatgtata tcaaaggaag
     1561 actgaggttt taagtataaa acttttcttc tgtttatagt agctaagtct tgacagggtt
     1621 caaaaaatgg tttacacttt ataaagttta ttactttgaa aaggtgtgat actgtggcta
     1681 cggcaacaaa aaagaaaaaa tcaacagtta aaaaaaatct agtcatcgtg gagtcgcctg
     1741 ctaaggccaa gacgattgaa aaatatctag gcagaaacta caaggtatta gccagtgtcg
     1801 ggcatatccg tgatttgaag aaatccagta tgtccgtcga tattgaaaat aattatgaac
     1861 cgcaatatat taatatccga ggaaaaggcc ctcttatcaa tgacttgaaa aaagaagcta
     1921 aaaaagctaa taaagttttt ctcgcgagtg acccggaccg tgaaggagaa gcgatttctt
     1981 ggcatttggc ccatattctc aacttggatg aaaatgatgc caaccgtgtg gtcttcaatg
     2041 aaatcaccaa ggatgcagtc aaaaatgctt ttaaagaacc tcgtaagatc gatatggact
     2101 tggtcgatgc ccaacaagct cgtcggatct tggatcgctt ggtagggtat tcgatttcgc
     2161 ctattttgtg gaagaaggtc aagaagggct tgtcagcagg tcgcgttcag tccattgccc
     2221 ttaaactcat cattgaccgt gaaaatgaaa tcaatgcctt ccagccagaa gaatactgga
     2281 cagttgatgc tgtctttaaa aagggaacca aacaatttca tgcttccttc tatggagtag
     2341 atggtaaaaa gatgaaactg accagcaata acgaagtcaa ggaagtcttg tctcgtctga
     2401 cgagtaaaga cttttcagta gatcaggtgg ataagaaaga gcgtaagcgc aatgctcctt
     2461 taccctatac cacttcatct atgcagatgg atgctgccaa taaaatcaat ttccgtactc
     2521 gaaaaaccat gatggttgcc caacagctct atgaaggaat taatatcggt tctggtgttc
     2581 aaggtttgat tacctatatg cgtaccgatt cgactcgtat cagtcctgta gcgcaaaatg
     2641 aggcggcaag cttcattacg gatcgttttg gtagcaagta ttctaagcac ggtagcaagg
     2701 tcaaaaacgc atcaggtgct caggatgccc atgaggctat tcgtccgtcg agtgtcttta
     2761 atacaccaga aagcatcgct aagtatctgg acaaggatca gctcaagcta tataccctta
     2821 tctggaatcg ttttgtggct agccagatga cagcggccgt ttttgatacc atggctgtta
     2881 aattgtctca aaatggagtt caatttgctg ccaatggtag tcaggttaag tttgatggtt
     2941 atcttgccat ttataatgat tctgacaaga ataaaatgct accagatatg gctgttggag
     3001 atgtggtcaa acaggttaat agcaaaccag agcaacattt cacccaaccg cctgcccgtt
     3061 attctgaagc aacactgatt aaaaccttag aggaaaatgg ggttggacgt ccatcaacct
     3121 atgcgccaac cattgaaacc attcagaaac gttattatgt tcgcctggca gccaaacgtt
     3181 ttgaaccgac agagttggga gaaattgtca ataagctcat cgttgaatat ttcccagata
     3241 tcgtaaacgt gaccttcaca gctgaaatgg aaggtaaact ggatgatgtc gaagttggaa
     3301 aagagcagtg gcgacgggtc attgatgcct tttacaaacc attctctaaa gaagttgcca
     3361 aggctgaaga agaaatggaa aaaatccaga ttaaggatga accagctgga tttgactgtg
     3421 aagtgtgtgg cagtccaatg gtcattaaac ttggtcgttt tggtaaattc tacgcttgta
     3481 gcaatttccc agattgccgt catacccaag caatcgtgaa agagattggt gttgagtgtc
     3541 caagctgtca tcagggacaa attattgagc gaaaaaccaa gcgtaatcgc ctcttctatg
     3601 gttgcaatcg ctatccagaa tgtgaattta cctcttggga caagcctgtt ggtcgtgact
     3661 gtccaaaatg tggcaacttc ctcatggaga aaaaagtccg tggtggtggc aagcaggttg
     3721 tttgtagcaa aggcgactac gaggaagaaa agattaaata agaggagggg cccgaaagta
     3781 aatttcaggc tccttttggt tagaacttga caaaatacat cattttatgc gaaactagaa
     3841 gaagattatt ttaactagga gaagttatgc gtcttatcta tctgataatt ggttttttat
     3901 cactggcctt ggctattgtt ggggttgttt tacccttgtt gccgacaacg cctttccttt
     3961 tgttgtctat tgcttgtttc tccagaagtt ccaagcgttt cgaagactgg ctttatcata
     4021 ctaagctcta tcaaacatat gtagctgatt ttcgcgagac taagtctatt acgcgtgaac
     4081 gaaagaaaaa aatcatcgtc tctatctacg tcttgatggg aatttctatt tattttgcac
     4141 ctcttttacc agtcaaaatc ggtctgggtg ctttgaccat ctttatcact tattatcttt
     4201 tcaaggtcat tccagacaaa gaatagttaa aacagtagtt atttgccttg ataaaattga
     4261 aagcatattc ataataatat gatataataa atttgaagta atattcaagg agaatcaaat
     4321 gatttacgaa ttttgtgctg aaaatgtgac tttacttgaa aaagcgatgc aggctggagc
     4381 tcgtcggatt gaactctgtg ataatctagc agttggtggg acaacaccca gctatggagt
     4441 gactaaggca gcggttgaac tggcagctaa ctacgataca accatcatga ccatgattcg
     4501 gccacgtggt ggtgactttg tctataatga cctagaaatt gctatcatgc tagaagacat
     4561 tcgtttgact gctcaggctg gaagtcaagg ggttgtattt ggaactttaa ctgctgataa
     4621 aaagttggat aagcctaatc tggaaaagtt aattgctgca tcaaaaggaa tggaaattgt
     4681 ctttcacatg gcctttgatg aactaagtga tgaagatcaa ccggaagcta ttgactggct
     4741 cagtcaagcc ggtgtcactc gtatcctaac tcgtgctggt gtgtctggcg actccttaga
     4801 aaaacgtttt gttcactatc acagaatttt ggagtacgct aaaggtaaaa ttgaaattct
     4861 accaggtggg gggattgacc ttgaaaaccg tcaaaccttt atcgaccagg tgggggtaac
     4921 acaattgcat ggtactaagg ttgtttttta aaaaatagaa aggaactgct agctttgggt
     4981 agcagttttc acttatgttt gaaattttta aatcctatca atttaatcaa gaaaaggctc
     5041 atgattatgg ttttatagaa aatagcgaag tctggacata tagttgccag attttgcaag
     5101 gtgactttgt catgactgtg tccatcactg ctgataatgt gaactttcaa gtctttgacc
     5161 aagagactgg tgacctctat cctcacgttc atatggaaag catgagggga agttttgtcg
     5221 gaaatgtccg tgaggcttgt ctggagattc tttaccagat tcggaaggct tgttttgatg
     5281 tgcaagattt tatctgtcat cagactaagc gtatcatgac tcaagttcag gaaaagtgtg
     5341 gaaaccagtt ggagtatctg tgggaaaaat cgcctgatac agctgtattg cgccatgaag
     5401 gcaatcaaaa gtggtatgcc gtcttgatga aaatctcttg gaataagctg gaaaagggca
     5461 gagaaggaca agtggaagca gtcaacctca agcatgacca agtagctaat ttgctttcac
     5521 aaaaggggat ttatccagcc ttccatatga gcaagcgcta ctggattagt gtgtcccttg
     5581 atgatacttt atcagatgaa gaagtactgg aattgataga aaaaagttgg aacttaacct
     5641 ctaaaaaatg aaatatttta ataattttca tgaactttca attggctaaa tattctttac
     5701 tgaagaaatt ttcagaaaat ataggattta ccacaccaga ggaatatggt gccatcttca
     5761 aatacctgat tgagaatgtc aagacggatc gtcagatcat ctattcgcct cactgtcatg
     5821 atgacctcgg aatagcagtg gcaaatagcc ttgctgctgt caagaatggt gcaggacgtg
     5881 ttgaagagac tatcaatggt attagggagc gagctggaaa tgctgctttg gaagaaattg
     5941 cagtggctct caatattcgc caagattact accaagtaga aaccagtatt gtcctaactg
     6001 agaccatcaa tacgtcagaa atggtttctc gcttccctgg tattccagtt cctaaaaaca
     6061 aagccgtcgt tggtggcaat accttctccc acgaatctgg tattcaccaa gatggagtcc
     6121 ttaaaaatcc tctcacttat gagaacatca cacctgaatt ggttggtgtt aagattccgc
     6181 ttggaaaatt atctggtcgc catgcttttg ttgagaaact gagagaattg gccctagatt
     6241 ttacagaaga ggatatcaaa ccactctttg ctaagttcaa ggcactggcc gataagaagc
     6301 aagaaatcac agatgcagat attcgagctt tggtagctgg aaccatggtt gaaaatccag
     6361 aaggcttcca ctttgatgat ttacaacttc aaactcatgc agataatgac attgaagcgc
     6421 tcgttagcct agccaatatg gatggtgaga aagtcgaatt taatgcgaca gggcaaggtt
     6481 ccgttgaagc aatctttaac gctatcgata agttctttaa tcaatctgtt cgtttggtgt
     6541 cctacactat cgatgcgata acagatggaa tcgatgccca ggatcgggtt ttggtcactg
     6601 ttgaaaacag agatacagaa accatcttta atgcaacagg gcttgatttt gatgtgttga
     6661 aggcttctgc tattgtctat ataaacgcta atacctttgt tcaaaaagag aatgcaggtg
     6721 agatgggacg cagtgtttct taccacgata tgcctagtgt gtaaaggaga aggctatggc
     6781 aaagaaaata gtagctctag taggagacgg aattggccca gaaatcatgg aggctggttt
     6841 agaagttctg gaggctctag ctgaaaaaca ggttttgact atgagattga cagacgaccg
     6901 ttcggaggtg cagatattga tgcagcagga cctcccttac ctgatgaaac ccttaaggca
     6961 agtagggaag cagatgctat cctactagca gctatcggta gtcctcagta tgatggagca
     7021 gcggttcgcc ctgaacaagg cctgatggct ctccgtaagg aactcaatct ttacgctaat
     7081 attcgtcctg taaaaatctt tgacagtctc aagtatttgt caccacttaa accggaacga
     7141 atttctggtg tagactttgt cgtggtgcgt gaattgacag gcgagattta ctttggagat
     7201 catattcttg aagagcgcaa agcgcgtgat atcaacgact atagctatga ggaagtggag
     7261 cggattattc gcaaagcctt tgaaattgca agaaatcgca gaaaaatcgt tactagtatc
     7321 gataagcaaa atgttctagc gacctcaaaa ctctggcgga aagtagctga ggaagtcgca
     7381 caggatttcc cagatgtaac cttggaacac cagctggtag actcagctgc tatgcttatg
     7441 attaccaatc ctgctaagtt tgatgttatt gtaacggaga atctttttgg agatatttta
     7501 tctgatgaat caagcgtctt atctggtaca cttggggtta tgccatcagc cagtcattct
     7561 gaaaatggac caagtctcta tgaacctatt cacggttcag cacctgatat tgcaggtcaa
     7621 ggaattgcca atcctatttc catgatttta tcagtttcca tgatgttgag agatagtttc
     7681 ggacgttatg aggatgcaga gcgtatcaaa cgtgctgttg agacaagtct ggcggcagga
     7741 attttaacga gagatatagg aggtcaggct tcaacaaagg aaatgacgga agctattatt
     7801 gcaaggttat gaagttagac gaaaaaatta ctctagtcct tttgatttgg aatgtcatca
     7861 ttttcttgat ttatggcatt gacaaattca aggcaagaag aagagcttgg cgcatccaag
     7921 agaaaatctt actcatttta gcccttactt gtggtggttt tggggcctgg ttagctggaa
     7981 tcacttttca ccacaagact cgaaaatggt actttaaaac agtttggttt cttgggatgg
     8041 tgaccacact agtagcctta tattttattt ggaggtaatg gatggcaggg tcttcgaggg
     8101 aacacgctgc ttgggttcta gcggactatg gctttaaggt cgtgattgca ggatctttcg
     8161 gtgacattca ttacaataat gaactcaata atggcctgtt gccaatcgtt cagcctaggg
     8221 aggttagaga aaagctagcc caactcaaac cgaccgacca agtaactgta gacttggaac
     8281 aacagaaaat tatctcacca gttgaagaat tcaccttcga gatagatagc gagtggaaac
     8341 ataaactcct aaatagtttg gatgatatcg gtattacctt gcagtatgaa gagttgattg
     8401 ctgcttatga aaaacaacga ccagcctact ggcaggatta gaaaaaatag aaaaggaaat
     8461 atagtaaact gaaataagat gtaaacaaat gaattagagc ttaacatcca tttccagcaa
     8521 ttttttagaa actacagtgg actattctgg attcaacaca ttataaaatt atgacaaaac
     8581 acattcacaa gaaggctacg acattttaaa aggtgagggc ggatgtatcg tttgccctac
     8641 taaagttggt tacattatca tgaccagtga caaggcagga cttgagcgta agttcgcagc
     8701 caaagagcgt aagcgtaaca aaccaggtgt tgttctctgc ggtagcatgg atgaactttg
     8761 cgctttagcg caactcaacc cagaaattga agcattctac taaaaacatt gggatgaaga
     8821 tattcttctt ggttgtatcc ttccttggaa accagaagcc tttgaaaaac tcaaagcata
     8881 cggggatggc cgtgaagaac ttatgactga tgtacgtggt actagctgtt ttgttatcaa
     8941 gtttggaaaa gcaggtgaac aattggctgc caagctttgg gaagaaggta aaatggtcta
     9001 cgcgtcatct gcttcaatga caaaacgatt gaaactcgct atgagcaagg tgtaatggtg
     9061 tctatggtcg ataaggacgg caaactcatc ccagaacaag gaggagcacg ttcaacttca
     9121 ccagctccag ttgtgatccg taaagggctt gacattgata tagtaaaatg aagtaagagc
     9181 aggacaaatt aatcaggaca gtcaaatcga tttctaacaa tgttttagaa gtagaggtgt
     9241 actattctag tttcaatcca ctataaaatc atgatgcacc tgtcagatac ttttaactca
     9301 tgggactacc gtcaggttga gtattattag gatagagaag aagtctagtg ttaaggacat
     9361 tacagctcat aatactaggc ttttttatag aaattctttt ctttttctat aggatatggt
     9421 attctatgta gaaaatatat gttaataagt aatgccaata tttaaacatc attagtaaaa
     9481 ggagttagat tgatgaataa aagaaaagtt agtttagaag atttttataa atggtatagt
     9541 ctaaataaag aagagttatt aaataaggca actgttggtg aaaagtttaa tgataaatta
     9601 aaagaagagt ttctccagga atggcctttg gataggattt taacaatgtc aatcgatgaa
     9661 tatgtaatag gaaagggaca gcaaaataag tctttatgct acgctcttga gaagggaaaa
     9721 tacaaaaatc tatttcttgg aatttctggt ggctcagctt caaaatttgg tatttattgg
     9781 aataaaaaaa caaacaaata taaagatcaa gctaataatg agatttcaga gttggatcag
     9841 cgattttcaa aattaaaatc agatttgtat gaaattatca aagaaggtat tcgttttaac
     9901 tttgaaaatc ctatttttga tatgaaaaga tcaacaaatg aatttattgg tcgttctgct
     9961 atggtgacaa aattactttg tatctattct gagggagatc ctttctttgg tgtaaatatt
    10021 aatagtcaga aagaattttg gaaccacttt gtttctcaga caaatcaagg tggaccttat
    10081 ctgcaaaatc ataaaataat tgaactggtg tccaaaactt atcctgagtt ggagccatcg
    10141 aaagtaggaa ctatgctttt tgagtattct aagcttttta tggaaaataa ggaagacaat
    10201 agtacaatgg attcatcaaa caattttcgt catcaattaa ctcaatctct attaaagtct
    10261 ccaaacctta tccttcgtgg tgctcctggc acaggaaaga cttatcttgc taaagaaatt
    10321 gccaaagaat taacggatgg caacgaagac caaatcggat ttgtacaatt tcacccatca
    10381 tatgattata cggattttgt agaaggttta agaccagtat caaatgggga tggagctatt
    10441 gagtttaggc tacaggacgg tatttttaaa gatttttgtc agaaagcaaa agaaacccaa
    10501 ttgattggag gacaagataa ttttgatgag gcttgggatt cttacttaga atatataaat
    10561 gttgctgaag aaaaagaata tataacaaaa acatcttact tatctgttaa tagtagacaa
    10621 aatttgtcag taaattatga tagtggtgtt ccaggatggt cactacctag caaatatgtt
    10681 tacgagttgt ataaagataa aaattataat aagcaagaat actacaaaag tggtggaaaa
    10741 actgtcctag aaacattgag aaagagattt ggtttgaaag actatgtttc cccaacagaa
    10801 attgatactg ataagaaatt cgtcttcatc atcgatgaaa tcaatcgtgg ggagatttct
    10861 aagatttttg gcgaactctt tttctctatc ggccctggct atcgtggtga aaaaggaagt
    10921 gtttctaccc aatatgcaaa tctacacgaa actgatgaaa agttctatat ccccgaaaat
    10981 gtttacatca tcggaactat gaatgatatt gatcgttcag tggatacctt tgattttgct
    11041 atgcgtcgtc gttttcgttt tgttgaagtt actgccgagg gtcaagttgg catgttggat
    11101 aaagagctga atatccatgc agaagaagca aaaattcgtc taagaaactt gaacgctgct
    11161 atcgaaaatg ttcaggaatt aaacagtcat tatcatattg gaccaagtta ttttcttaag
    11221 ttgaaggatg tagattttga ctatgaatta ctctggtctg attatattaa gcctctccta
    11281 gaagactact tgcgaggttc ttatgatgag gttgaaactt tggaaacttt gaaaaaagca
    11341 tttgaactga caaataatga gcaaaaagat caggcagtag ctgatgacaa tgaaggtgat
    11401 gaaaacgatg atgcggatta ctgataatca acacaagatt attaaagaaa aatttgttga
    11461 agaatatcct aaactaagca atcttctttt agacagaacc ttggaaagtt tatcccaaga
    11521 tgaacgtatt ttcatttttc caaatgattt gactcatact cctgatttgg ataaggacca
    11581 aaagattttt gaaacagtca atcagaaaat caagacaggg aacgtgattg gttttcttgg
    11641 atatggtcag gaaagattaa cgatttcctc acgattttct gatgagagta atgaccattt
    11701 tttgcattat ctcttaaaca aggttcttca tatcaatctc actagtttag atgttgcttt
    11761 gtctcgtgaa gagaggcttt atcaactttt ggtgtatctc tttcccaagt atctacaagc
    11821 tgctattcga aaaggtcttt ataaggaata tcatcgattt tctcataacg acagtaatgt
    11881 taagggagtg attgatgtaa gaagccatct caagaaaaat cttcctttca cgggaaatat
    11941 tgcctacgca acgagagagt tcacctatga taatcccctc atgcagttgg tccgtcacac
    12001 tattgaatac attaagaatc agaaaagcat tggtcaaggg gtactagata atctctcaac
    12061 tagtcgtgaa aacgtatctg aaatcgtgcg tgtaacgccc tcttataaac tagctgatcg
    12121 tgctaagatt attcggggaa atcaatctaa acctatacgt catgcatact ttcacgagta
    12181 cagaaactta caagaacttt gtctgatgat cctaaaccaa gaaaagcacg gtttagggta
    12241 tcaagatcaa aaaatctatg gtattctctt tgatgttgcc tggctttggg aagagtatgt
    12301 ttacaccttg ttgccaaaag gttttgtaca tcccagaaat aaggataaga cggatggaat
    12361 ttcagtattt tctgttggga aacgaaaagt atatccagat ttttatgaca gagaacgaaa
    12421 gattgttcta gatgcaaaat ataaaaaact ggaattgact gaaaaaggaa tcaaccgtga
    12481 ggacttattc cagctgattt cctattctta tattttaaaa gctgagaagg ctggactgat
    12541 ttttcctagt atggagcagt cagtaaatag tgaaatagga aaagtagctg gctatggagc
    12601 tcaattgaag gagtggtcta ttcgaatccc tcagaatgcc tcattctata gtacattttg
    12661 taaaatgatg gaaaattcag aagaaaattt taaagcgatt attgatgaag aagtggggag
    12721 aaaataattt cccctctttc ttttattttt aacacaagta aaacccgaac gatatatttt
    12781 aattcataaa ataatttgac aaaaactgta ctttggttta taataaatta aggaaacgtc
    12841 ggaaaaggcg tagtgatgca agagcatagg taggtcatta caaaagaaac gagacatcga
    12901 tatgttaaat gaatttccaa tttttgatta cgaagatatt caattgattc caaataaatg
    12961 tgtcattaaa agccgtgcag aagcggatac aagtgtcact ttaggaaatc acacctttaa
    13021 actacctgtt gtgccagcga atatgcagac gattttggat gaaaatgtag cagagcaact
    13081 ggctaaaggt ggttacttct acattatgca ccgttttgat gaggcaggac gcattccttt
    13141 tattaaacga atgcacaatc aagggctcat tgcttccata tctgtcggtg ttaaggacta
    13201 tgagtatgat ttcgttagac agctcaagac tgatgctcct gagtatatca ctattgatat
    13261 tgctcatggt catgcggata gcgtgatttc tatgattcaa cacatcaaga aagaattgcc
    13321 agataccttt gtcattgctg gaaatgtggg aacaccagaa gctgtgcgtg aattggaaaa
    13381 tgctggtgcg gatgctacta aggtcggaat cggtcctggt aaggtttgta tcaccaaggt
    13441 taagactggt tttggtacag gtggttggca gttggctgct ctacgctggt gtgccaaggc
    13501 tgcgcgtaaa ccgattatcg ctgatggagg aattcgtact cacggtgata ttgccaagtc
    13561 tatccgcttc ggtgctagca tgatcatgat tggttccctc tttgcaggac atattgaaag
    13621 tccagggaaa acgattgaag tcgatggtga acagttcaaa gaatattatg gttcagcctc
    13681 acaatatcaa aaaggtgctt acaaaaatgt ggaaggcaaa cgtatcttgc ttcctactaa
    13741 aggtcatctg caagacactt taactgagat ggaacaagac cttcaaagtg ctatttctta
    13801 tgcaggtgga cgtcaggttg ctgaccttaa acacgttgat tatgtgatcg tgaaaaactc
    13861 catctggaat ggggatgctt cccactaaga cggggtcttt gactaaaaaa cttgttatta
    13921 gagcaaattt ctgttataat aaaacaagtt tccaccctta gtgtaatgga tatcacgtaa
    13981 gattccggtt cttgagatgg gggttcgatt ccctcagggt ggatgtaaac attctaaaaa
    14041 gcctttaata gggctttttt ctttacacta ctctaaattt gccactaaaa ctgagaatct
    14101 ctgtctaaag aattcccaaa tgctttccag tcccgtttta gagtgactca gggggctttt
    14161 tttgatataa taaaaaggac tgttatcagt tagaaagagg ttggtatgaa agaattacaa
    14221 actgtactaa agaaccattt tgcaatcgaa tttacagaca aaaagttact ggaaactgcc
    14281 tttactcata cgagttatgc caatgagcac cgcctcttaa aaatttcaca taatgaacgc
    14341 ttggaatttt taggagacgc tgttctacag ttattgattt cagaatatct gtataaaaaa
    14401 tatcctaaaa agcctgaagg tgacctatca aaactccgtg ctatgattgt ccgtgaggag
    14461 agtttagctg gttttgcgcg tgattgccag tttgaccagt ttatcaagtt gggtaaaggg
    14521 gaagaaaaat ctggtggtcg caatcgtgac accattcttg gtgatgcctt tgaagccttt
    14581 cttggtgccc ttcttttgga taaggatgtg gccaaggtca aggaatttat ctatcaagtc
    14641 atgattccta aggttgaagc aggcgaattt gagatgatta cagactataa aacccatctc
    14701 caagagttac ttcaggtcaa tggtgatgtg gctattcgtt atcaggtgat ttctgaaaca
    14761 gggcctgctc acgataaggt ctttgatgta gaagttcttg ttgaaggtaa gagcatcggt
    14821 caaggccaag gtcgttctaa gaaattagca gagcaggaag ctgccaaaaa tgccgttgag
    14881 aaggggctgg attcatgtat ttaaaggaaa tcgaaattca ggggttcaag tcttttgctg
    14941 ataagaccaa ggtcgttttt gaccaaggtg tgacggcagt tgttggaccc aatggatctg
    15001 gaaagtccaa tattacagaa agtctgcgtt gggctttggg ggagtctagt gtcaagagtc
    15061 tccgtggggg caagatgccg gatgtcatct ttgctggaac agaaagtcgc aaaccgctca
    15121 attatgcttc tgtagttgtg actctggata atcatgacgg atttatcaag gatgcaggtc
    15181 aagaaatcag ggtggaacgc catatctatc gtagtggaga tagcgaatac aagattgacg
    15241 gcaagaaagt ccgtctgcgt gatattcatg accttttctt ggatacaggt ttgggacgag
    15301 attccttctc tattatttcc caagggaagg ttgaggagat ttttaattcc aagtctgagg
    15361 aacgacgagc tatttttgaa gaagctgctg gagttttaaa atacaagact cgcagaaaag
    15421 aaaccgagag taaactgcag caaactcagg ataatctgga ccgcttagag gacattatct
    15481 acgagttgga taatcaaatc aagcctcttg agaagcaagc tgagaatgcc cgtaaatttc
    15541 tagacttaga aggtcaacgc aaggctattt acttggatgt attggttgct caaatcaagg
    15601 aaaataaggc agaactagag tcgacagaag aagagttggc tcaggttcaa gaactcttga
    15661 tgagttatta ccaaaagcgt gaaaaattag aagaagaaaa tcaaactctt aaaaagcaac
    15721 gccaagattt acaggctgaa atggccaaag accaaggcag tttgatggac ttgactagtc
    15781 tgattagtga tttagaaaga aaattagccc tatcgaaact ggagtctgag caagtggcct
    15841 tgaatcaaca ggaggcacaa gctcgtttgg ctgctttgga ggataagaga aattcactca
    15901 gcaaagaaaa gtctgataaa gaaagctctt tagctctgtt agagggaaat ctagtccaaa
    15961 ataatcaaaa actcaatcgt ttagaagctg aattgctggc tttctcagac gatcctgatc
    16021 agatgattga gctcttacgt gaacgctttg tagctctttt acaagaagaa gcggatgtct
    16081 caaaccagtt gacccgtatt gagaatgagt tggaaaatag tcgtcagctt tctcaaaaac
    16141 aagcagatca actagaaaag ctgaaagagc aattagctat agctaaagag aaggctagtc
    16201 agcaaaagga agagcttgaa actgccaagg agcaggttca gaaattattg gctgactacc
    16261 aagctattgc caaggagcaa gaggagcaga aaacttccta tcaagctcaa caaagccaac
    16321 tctttgaccg tctggataat ctcaaaaaca agcaggccag agctcaaagt ttggaaaata
    16381 tcctgagaaa tcatagtaac ttttatgcag gtgttaagag tgttctccaa gaaaaagatc
    16441 gcctaggtgg gattattggt gcagtcagtg agcatctgac ctttgatatg cattatcaaa
    16501 ctgccctaga aattgcgctt ggagcgagta gccaacatat catcgtagaa gatgaagagt
    16561 cggcaaccaa ggctattgac ttccttaaac ggaacagagc cggtcgtgca acctttcttc
    16621 ctttgaccac tatcaaggcg cgtacgattt ctagtcagaa ccaagatgct atcactgtaa
    16681 gcccaggttt ccttgggatg gcagatgagt tggtgacttt tgatactaga ctggaagcca
    16741 ttttcaagaa cttgctagct acgacggcta tctttgatgc cgtagaacat gcgcgtgcag
    16801 cagctcgcca agttcgttat caggttcgta tggtgacatt ggatgggaca gaattacgca
    16861 cgggtggttc ctatgcgggt ggtgccaatc gccaaaataa cagtattttc atcaagccag
    16921 aactggagca attacaaaaa gaaattgctg cagatgaagc aagcttgcgt tcagaagaag
    16981 cggctttgaa gaccttacaa gaccagatgg ctacattgac agaaagatta gaagtcatca
    17041 aatctcaagg agaacaggca cgtattcagg agcaaggctt gtccctcgct tatcagcaaa
    17101 ctagtcagca agttgaagaa ctggaaactc tttggaaact ccaagaagag gaaatagatc
    17161 gtctttccga gggagattgg caagcggata aggaaaaatg ccaagatcgt cttgctgcaa
    17221 tcgccagtga caagcaaaat ctggaagctg agattgaaga gattaagtct aacaaaaatg
    17281 ccatccaaga acgctatcaa aacttgcagg aagagctagc gcaagctcgt ttgcttaaga
    17341 cagaactgca agggcaaaaa cgttatgaag ttgctgatat tgaacgctta ggcaaggaat
    17401 tggacaatct tgattttgaa caagaggaaa tccagcgcct tcttcaagaa aaggttgata
    17461 atcttgagaa ggttgataca gaattgctca gtcaacaggc ggaagaagcc aaaactcaga
    17521 aaacaaatct ccaacaaggt ttgattcgca agcagtttga gttggatgat attgaaggtc
    17581 aactggatga tattgctagt catttggatc aggctcgcca acagaatgaa gagtggattc
    17641 gcaagcaaac acgtgctgaa gccaagaaag aaaaggttag cgagcgcttg cgctatttac
    17701 aaagtcaatt aacagaccaa tatcagatta gctatactga agctctagaa aaggcgcatg
    17761 aattggaaaa cctcaatctg gcagagcaag aggtgcagga tttagagaaa gctattcgct
    17821 cactggggcc tgtcaatata gaagctattg accagtacga agaagttcac aatcgtctgg
    17881 atttcctaaa tagccaacga gatgatattt tgtcagcgaa aaatctgctc cttgagacca
    17941 ttacagagat gaatgatgag gtcaaagatc gctttaaatc aacctttgag gccattcgtg
    18001 aatcctttaa agtgaccttc aaacagatgt ttggaggagg tcaggcagac ttaatcttga
    18061 ctgagggaga cttgttgaca gctggggttg agatttctgt tcaacctcca ggtaagaaaa
    18121 tccagtcgct taacctcatg agtggtggtg aaaaagcctt atcagctctt gctttgcttt
    18181 tttctatcat tcgagttaag actatcccat ttgtcatctt ggatgaggta gaggccgcgc
    18241 tggacgaagc caatgttaaa cgttttgggg attacctcaa tcgatttgac aaggacagcc
    18301 agtttatcgt cgtaacccac cgtaagggaa ccatggcagc ggctgattct atctatggag
    18361 tgaccatgca agaatcgggg gtctcaaaaa ttgtttcggt taagttaaaa gatttagaaa
    18421 gtattgaagg atgacaatta aactagtagc aacggatatg gacggaacct tcctagatgg
    18481 gaatggacgc tttgatatgg accgcctcaa gtctctctta gcttcctaca aggaaaaagg
    18541 gatttacttt gcggtggctt cggggcgcgg atttctgtct ctagaaaaat tatttgctga
    18601 tgttcgtgat gacattattt ttatcgcaga aaatggcagt ttggtagagt atcgaggtca
    18661 agacttgtat gaagcgacca tgtctcgtga gttttatttg acgacttttg aaaagctgaa
    18721 aacttcacct tatgtagata tcaataaatt gctcttgacg gggaaaaagg gagcttatgt
    18781 tctagatacg gttgatgaga cctatttgaa agtgagtcag cactataatg aaaatatcca
    18841 aaaagtagcg agtctggaag atattacaga tgacattttc aaatttacga ccaacttcac
    18901 agaagaaacg cttgaagctg gggaggcttg ggtcaatgaa aatgtccctg gtgttaaggc
    18961 catgacaact ggctttgaat ccattgatat tgttctggac tatgtcgata agggtgtggc
    19021 cattgttgaa ttggctaaaa aacttggcat cataatggat caggttatgg cttttggaga
    19081 caatctaaat gatttgcata tgatgcaggt tgtgggacat cctgtagctc ctgaaaatgc
    19141 acgacctgaa attttagaat tagcaaagac tgtgattggt caccataagg accagtcggt
    19201 tatagcttat atggagggct tataatggca gatataaaat taatcgcatt ggacttggac
    19261 ggtaccttgc tgactactga taaaaggctg acggatcgca ccaaggcaac tttgaaagct
    19321 gcgagtgatc gtggtatcaa ggtcgtattg acaactggtc gtcccttaaa agccatggac
    19381 ttctttctcc atgagttagg gactgacggc catgaagatg agtataccat tacttttaat
    19441 ggtggattag ttcagaaaaa tacaggagaa atccttgata aaacagtctt ttcatatgat
    19501 gatgtggcac gtttgtatga ggaaacagag aaattatcac tgcctcttga tgccatctca
    19561 gaaggaacag tttatcaaat ccaatcggac caagaaagtc tttatgccaa attcaatcca
    19621 gctttgactt ttgttccagt tgactttgaa gacctgtcta gtcaaatgac ctacaacaaa
    19681 tgcgtgactg cctttgctca agaacccttg gatgcagcca ttcagaagat ttctccagaa
    19741 ttgtttgacc aatatgaaat ctttaaatca cgtgaaatgt tgctagaatg gtcaccaaag
    19801 aatgttcata aagcaacagg tttggcaaaa ctaattagcc atcttggaat tgatcaaagt
    19861 caagtgatgg cctgtggtga cgaggccaat gacctctcta tgattgaatg ggcagggctc
    19921 ggtgttgcca tgcaaaacgc tgttcctgaa gtaaaggcag ccgcaaatgt agtgacgccg
    19981 atgaccaacg atgaggaagc tgtcgcctgg gctatcgaag aatatgtgct aaaggagaac
    20041 taagatatgg gattatttga ccgtctattc ggaaaaaaag aagaacctaa aatcgaagaa
    20101 gttgtaaaag aagctctgga aaatcttgat ttgtctgaag atgttgatcc taccttcaca
    20161 gaagttgaag aagtttctca agaagaagct gtgcttgaag aaagtcagga ttcagagcca
    20221 gctgtagggg tttctcaaga agaaatagaa gaattaccag aggaagagaa gcttgagcac
    20281 gaaggaacta tagaagaaaa taattctgaa gttcttgaag cagaaaggcc tcaagcagaa
    20341 gaaaccgttc aggaaaaata tgaccgcagt cttaagaaaa ctcgtacagg tttcggtgcc
    20401 cgcttgaatg ccttctttgc taacttccgc tctgttgacg aagaattttt tgaggaactg
    20461 gaagaactgc tgattatgag tgatgttggt gtccaagtcg cttctaactt aacggaggaa
    20521 ctacgttacg aagccaagct tgaaaatgcc aagaaacctg atgcacttcg tcgtgtcatc
    20581 attgagaaat tggttgagct ttatgaaaag gatggtagct acgatgaaag catccacttc
    20641 caagataact tgacagttat gctctttgtt ggtgtgaatg gtgttgggaa aacaacttct
    20701 atcggaaaac tagcccaccg ctacaaacga actggtaaga aggtcatgct ggttgcagca
    20761 gataccttcc gtgcgggtgc agtagctcag ctagctgaat ggggccgacg agtagatgtt
    20821 ccagtagtaa ctggacctga aaaagctgat ccagccagcg tggtctttga tggtatggaa
    20881 cgtgccgtgg ctgaaggtat cgatattctc atgattgata ctgctggtcg tctgcaaaat
    20941 aaggataacc ttatggctga gttggaaaag attggtcgta ttatcaaacg tgttgtgcca
    21001 gaagcaccac atgaaacctt cttggcactt gatgcatcaa caggtcaaaa tgccctagta
    21061 caggccaaag aattttcgaa aatcacacct ttaacgggaa ttgttttgac taagattgat
    21121 ggaactgctc gaggaggtgt ggttctagcc attcgtgaag aactcaatat tcctgtaaaa
    21181 ttgattggtt ttggtgaaaa aatcgatgat attggagagt ttaactcaga aaactttatg
    21241 aaaggtctct tggaaggctt aatctaatca gaagcaaaaa tcctgcaagg tacaaacttg
    21301 caggattttt ttattcgaaa cgaccatctt gacgataggc gatatctggt tgccaagtcc
    21361 atttggcatc gaatttttca agtaggtcaa agctggcttg aggtcccatg cttccagctt
    21421 tatagtcatg aagtggggca ccattttcgg cccagagctc ttcaatacgg tcaatcaact
    21481 tccatgacgc accaacctca tcccagtggc taaagttagt tgagttgtta tttaggacat
    21541 cataaatcaa tttctcgtat ggttctggag aagcaccagt tgcagtcgcg tctgtacgat
    21601 aatcaagtga gttaggagcc aagttaaatt cttctcctac ttgcttccca tttaggctaa
    21661 gagagaagcc ttctgttggt tgaatataga tggtcaaaat atttggagca agtggttctc
    21721 caaagataga atccatttgt ttaaagacga tgttgacatg agttcctttt tcagtcagtc
    21781 gtttacctgt acggaaaaag aaaggaacac cacgaaatcg atcgctgtct acaaagaagg
    21841 caccagatgt aaaggtttca gttgttgatt ctggattcac atttggttcg ctacgataag
    21901 agatgtattt catgccatca atcttaccag agcggtattg tccacggata aagtgttctt
    21961 tgagttcttc atcagttgga tgatagaggt ttttaaagac cttaatcttt tcagcacgaa
    22021 tctcgtcttt tgtgaagctt gctggtttgt ccatggcgag gagcgaaaga agttgtagag
    22081 tgtggttttg gaccatgtca cggagggcac cggattggtc atagtagcca ccacgttctt
    22141 ctacacccaa gcgctccgca aaggtaattt gaacattgtc gataaaatcc ttgttccaaa
    22201 cgttttcaaa aatcaagttt gcaaagcgaa ctgcaaagat gctttggatc atttccttac
    22261 caagataatg gtcaatacgg aaaatttgtt cttcgtcaaa tgttgctagg agttcgtcat
    22321 tcaacttgct tgcagttgcg taatctgtac caaatggttt ttcaacgatc aagcgctcaa
    22381 aacctttgcc atcgacaatg ttttcagatt tgaggtgttt ggcaatggtt ccaaagaact
    22441 gaggtgccat agacaagaag aagagcttat tgtgttcagc ttggtatttt tcattaagct
    22501 cagcttgtaa ttgacgcaaa gcaatataat gttccgaatc attgacatca tggctttgat
    22561 agtagaagtg gctagcaaat tcttgggctt gctcggtact atctgccaaa tcaaggatgg
    22621 actcgacaac tacagattca aaatattcct tactccaagg tctacgggca gttccaataa
    22681 cggcaaagtg cttggaaaga ttgccggatt gatatagtct aaaaagggaa gggtagagct
    22741 tgcgtttagc caggtctcca ctcgcaccga aaattgtaac aataacctta gatgacatct
    22801 agctacctaa tttctatttt tattcctagt cttgctaggt atgaggaaac ctcatttcat
    22861 aaacttaatt ctaacataat tttccgaaaa atcaaaaatt ccaatacgag gtagaaaaac
    22921 tgcaaggaaa tccttacagt ttgagtttag acgtttaaga ccttatctaa gaactctttc
    22981 agacgagggt gttgtgggtt atcaaagatt tggtcaggtg ttccgtcttc aaggaactcg
    23041 ccatctgcag taaagataac gcggttggca acctgacgag caaatcccat ctcatgggtt
    23101 acgataatca tggtcatgcc ttgctcagcc aattccttca taacgttaag tacgtctcca
    23161 accatctcag ggtcaagggc agaagttggt tcatcgaaga gcatgatgtc tggattcatt
    23221 gctaggccac gagcgatggc cacacgttgt ttttgaccac ctgataggct atctggattg
    23281 gcattagctt tatctgctag tccaaccttt tcaagcaact ccattcccaa ttcctcagct
    23341 tcttccttag tcatcaactt gtgctcaata ggagcaaagg tgatgttgtc caatacagac
    23401 atatgaggga agaggttgaa gtgttggaat accatgccga tattttcacg gacgtggtca
    23461 acattggttg ttttttcagt taaatcatag ccgttcacag tgatgtgacc gctagtgact
    23521 tcttctaaaa gattgaggct acggaggaaa gttgacttac cagaacctga aggaccgatg
    23581 atacaaacaa catctccttc atagaactta gtcgtaattc cttttaggac ttcatttttt
    23641 ccatagtact tgtgtaaatc atttacatca atttttaatt ttgccattaa cgaatcctct
    23701 tttctaagcg tttcgctagt ctagtcaaaa gtgtgataat tacaagatag aagatagcaa
    23761 ggattgcata catcttgaaa ctttggtagt tacgagcaat gataatctta ccagtttgga
    23821 agagttcaac caaaccgata gcagatacga tagttgtatc tttaagagcg ataacgaatt
    23881 ggttgacaaa gtttggcaac atcaatttag ttgattgtgg caagataatc ttacgcatgg
    23941 tttttccata agagataccc aagcttcggc tggcttccat ttggccaact ggaacggcct
    24001 gaataccacc acgaacgatt tcagcgatat aagcagccgc attgagtgag agggcaattg
    24061 ttccagctac aaagtcgtta attgggcttt gttggcctgt gatagactcg atgaagtttg
    24121 gaattcccca gaagatgaag gctgcaagaa tcatcaatgg aataccacga ataacgtcaa
    24181 cgaaaatctc agagatgacg cgaagagatt tgtatgggct aacgctaaac ataccgaaga
    24241 taattccgat gacaatggca atagcaaatg agataagagc tagagcaaga gtgataccaa
    24301 gaccgctaag gagttgtttg tagttgtttt gaagcaagcc ccagagcgtt gtttcgtcaa
    24361 cagtacttgt tgaagcagtt gaagattcgc tagctaggta tttgtcaaga atcttttgga
    24421 attcaccgtt tgctttaagg tttgcaagtc cgttgttgaa catttcaatc agttctggat
    24481 ttgctccttt tttaacggca aaggctgttt caccgattgg agttccagag attggagttt
    24541 tcaatttttg accttggctg atagaatatt tgagaacagg ttcatcatcc ataacggcat
    24601 caatggcacc agtgtttaaa ctgtcataca ttgaagaacc atcagcaaag gttttgattt
    24661 tgtaaccgta tttgctttga ttttctgtta ggaaggtttg agaagcagtt ccgtttttaa
    24721 caccgactgt ctttcctttt agatcttcat aagaagcaat attgcttgat tctttgacac
    24781 caagaatggt attagcagtg tagtatgatt ctgagaagtc aaaagttgcc ttacgagcat
    24841 ctgtgacaga cataccagca atgataccat cggcttgacc agcttggaca gcactgatag
    24901 cagcatcaaa accagggttg gtgatttcaa tttcaaaacc ttggtcttta gcgattgcct
    24961 taatcaattc catatcaata ccagtgtatt ggttgcttga attttggaaa acaaaaggtg
    25021 caaaagaaga atcgctggca atgatatatt tagccttaac aggaatagct tttaatcctg
    25081 cgagagtagt tgtagttggc actgctgaag atgatgaagc agtccatttc ttgataattt
    25141 tatcaagact accatctttt ttcatttcag ccaaggcttg gttaaattca gtaaccaggt
    25201 gctcgtattt acttcctttt ttcacaccga aagcaaaact tcctacagct tcaccatcca
    25261 tttcaatatg gaggtcttga ccttggttaa tggcatattc gataacaggt ttgtcatcca
    25321 tcatggcatc gatggcacca gcactcaagc tgttgttcat taaatcacca gtgtcaaatg
    25381 ttttaatagt aaagccgtat ttatctttga ttgtttcaag gaaacgttga gcggcagttc
    25441 cgtttttaac accaacggtt ttgccagtta attggtcgta cttgctaatt ttgtgtgact
    25501 ttgtagtagc aatgacaact tttgtatcat agtaagtatc agacatggtg aagacttttt
    25561 cacgttcttt agtctttgtc atccctgcca tgatagcgtc ggcttgccca gcttgaaccg
    25621 cattgactgc tgcgtcaaat ccaggatagg acatctgaat gttccagcct ttaatctcag
    25681 cgactttgtt aataatgtca acatcaattc ctttataagt ttgatctgaa tctttaaact
    25741 caaaaggtgc ataggcggta tcagaaacaa tcttaatcgt ttctgctttg gcaataccta
    25801 atgagaaaat tgggaataaa attagcaaaa atgctagaaa ttttttcttc atttttagtc
    25861 tccttttccg aatattctct cattatatca gaaaaagtaa aaaaaggcaa atttttatat
    25921 ttttcgtgtc agaaaatata acattgattt ttccttttct ttcttgaatt gctattaaaa
    25981 agtgatataa taatagtata tatagaagaa aagaggacgg ggatatgaag aacaaaagaa
    26041 tatttaaaga cttccaagct tcaaaaatga atttaaacat ttacacaagc cccttgttag
    26101 cctttgtttt tgtcttcata ggagagtttg tggcttatac tttatatggt attagtttgt
    26161 tagctctcat cggacttgct agaaattttg gagaggctgg tcaaaatctt gcaagctact
    26221 tgcagacctt gcatcagagc ttgacggata aaacaagtga ctttcgttta attttaggat
    26281 tactggcctt tggttttatt cttaacactg tgttcagatg gacaagaaaa gttgagaaaa
    26341 gacctattcg aaccttggga ttttatagag agaatttcct cagcaatctt ctgaaaggat
    26401 ttagtctagg tctggcactt tttcttctga ccttgttagg tttggtggtc ttaggtcaat
    26461 atcgtttgga atccattcac ttgaatcctt attctcttgc ctttgtcgtc tttactatcc
    26521 cattttggat tttacagggg acagcagaag aagtggtggc ccgtgcttgg ctacttcctc
    26581 aattggcctc aagaaccaat ctaaaactag ctattcttat atctagcctg ttctttaccc
    26641 tgcttcatat gggcaattct ggtctcaccc ctctatctct agtaaatctc tttttattcg
    26701 gagttgccat ggctctttac cttctcaaaa ctgatacagt ttggggtgtt gcaggtattc
    26761 atggtgcttg gaattttgct cagggtaatc tctttgggat tttagttagt ggtcaaccgt
    26821 caggaacgtc tctgatgacc tttttaccac aaggcaatca agattggcta tcaggtggtt
    26881 cttttggcat agaaggttcc attatgacaa gtctggtatt actactgctg attgtctatc
    26941 ttgctaataa attaaagaaa gaaaatgaaa ggatgtgact tcggtccgtc cttttcttcg
    27001 tgaaaatact ataagtatgc taaaatagga atagcacatg gagagaggat tcttatgatc
    27061 aatcacatta cagataatca atttaaacta gtatcaaaat atcaaccatc aggagatcaa
    27121 ccccaagcta tcgagcagtt ggtggataac attgaggggg gagaaaaagc tcagattctg
    27181 atgggggcga ctggaacagg gaagacctat actatgagtc aggtcatttc taaagtcaat
    27241 aaaccaactc tggttattgc ccacaataaa actctggctg gtcagctcta tggggagttt
    27301 aaggaatttt tccctgaaaa tgcagttgag tatttcgtat cctactatga ttattaccag
    27361 ccagaggcct atgtcccttc tagcgatacc tatattgaga aggatagttc tgtcaatgac
    27421 gagattgaca agcttcgcca ctcagctacc tcagcccttt tggagcgtaa tgatgttatt
    27481 gtcgtggcct cagtctcttg tatctatggt ttgggttcgc ccaaggaata cgctgatagt
    27541 gtcgttagtc tccgtcctgg tctagagatt tctcgtgata aactcttgaa tgacttggtc
    27601 gatattcagt ttgaacgtaa tgatattgat ttccaacgcg gaagatttcg cgttcgtggg
    27661 gatgtggtag agattttccc agcttcccga gatgaacatg cctttcgagt agaatttttt
    27721 ggagacgaaa ttgaccgtat tcgtgaagtt gaggctctga caggtcaggt gttgggagaa
    27781 gtggatcatt tagcgatttt cccagcgaca cactttgtga ccaatgacga ccacatggaa
    27841 gttgccattg caaagattca ggccgagttg gaagaacaat tagctgtctt tgaaaaggaa
    27901 ggtaaactgc ttgaagccca gcgtttgaaa cagcggacag agtatgatat cgaaatgttg
    27961 cgtgagatgg gctataccaa tggggttgag aactattcac gacacatgga tggacggagc
    28021 gaaggagagc ctccttatac gctcttagat ttcttcccag atgatttctt aattatgatt
    28081 gacgagagtc acatgaccat ggggcaaatc aagggcatgt acaatggaga ccgttcgcgt
    28141 aaagaaatgc tggttaatta tggcttccga ttgccgtctg ctttggacaa tcgtcctctc
    28201 cgtcgggagg agtttgagag tcacgttcat cagattgttt acgtttcagc gacacctggt
    28261 gactatgaaa atgaacagac tgagacagtg attgagcaaa tcattcgtcc aacgggactc
    28321 ttggatcctg aagtggaagt ccgtccgact atgggacaga ttgatgacct cttgggtgaa
    28381 atcaatgccc gcgttgaaaa aaatgagcgt acctttatca caactttgac caagaaaatg
    28441 gcagaggact tgaccgacta cttcaaggaa atgggtatca aggtcaagta catgcactcg
    28501 gatatcaaga ccttggaacg gacggagatt atccgtgacc tgcgcttggg tgtctttgat
    28561 gtcttggtcg gaattaacct gctccgtgaa ggaattgacg ttcctgaagt gagcctcgta
    28621 gctattctcg atgctgataa ggaaggtttc cttcgcaacg aacgtggact catccagact
    28681 attggacgtg ctgctcgtaa cagtgaaggc catgtcatca tgtatgcaga cacggttacc
    28741 cagtctatgc aacgtgctat cgatgaaact gcccgccgtc ggaaaattca gatgacctat
    28801 aatgaagagc atgatatcgt accacagaca atcaagaaag aaatccgtga cctgattgcc
    28861 gtgaccaagg cagttgctaa ggaagaggac aaggaagtcg acatcaatag cctcaacaaa
    28921 caagagcgca aggaactcgt caagaaacta gaaaaacaaa tgcaagaagc cgtcgaagtg
    28981 cttgactttg aactggcggc tcagattcgt gatatgatgt tggaagtcaa ggtcttggat
    29041 taggggaata gtatgattta tttaagaaag ttaaagagag aagatttgat gtctttatgg
    29101 gaaatggctt attcacaact taatccagtt tggaaacagt atgatgctcc ctattatgat
    29161 gattatcagt atttttcaaa ttttaaagaa ttcgaactac aaaaatcaga atccatttta
    29221 agcaactcaa atcgccttgg tatttttgtt gatgataaac tagttgggac tgtttcgcgt
    29281 tattgggtat gtaaacaaac aagatggatg gaattgggaa ttggtattta tgataaaaaa
    29341 ttctggaaca ctggtattgg gaaagttgct atgttgcagt ggatagatag gacgtttcag
    29401 gattacttgg agttggagca tctgggtttg acaacttggt cagggaatct tggtatgatg
    29461 aaacttgctg aaaaattaag aatgaaaaaa gaagctcata ttccaaaagt tcgttattat
    29521 caaggtaaat attttgatag tattaaatat ggtattttga gagaagactg ggagaaaata
    29581 aatgacggtt attatcaaat caatggaaac tcctgaagag atagaaggta aatcccttgt
    29641 tcactggcaa acgtggagag aggcttatga tgaccttttg cctgcagaat ttcaggaaac
    29701 aatgacatta gaaagatgtc gattctttag tcaaaagtat ccagaaaata cattgattgc
    29761 gatagatgac ctgaaggtag ttggttttat cagttatggc agctttcgtg atgagactat
    29821 tcaagctggt gaaattattg ctttatatgt tttaaaagac tattatggaa aaggaatcgc
    29881 acaaaagtta gtgaaagtag ctttgactgc tcttaatcat ttttctgaaa ttttcttatg
    29941 ggtattgaaa gataataagc gcgccattgc tttctatcaa aaaatgggtt ttacttttga
    30001 tggacaagaa aagatacttg aacttggaaa gcctataaag gaaaaacgga tggtattcta
//
LOCUS       DAVLHC010000026        28109 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.026, whole genome shotgun sequence.
ACCESSION   DAVLHC010000026 DAVLHC010000000
VERSION     DAVLHC010000026.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 28109)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 28109)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..28109
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.026"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(418..1146)
                     /locus_tag="VXE25_001270"
     CDS             complement(418..1146)
                     /locus_tag="VXE25_001270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000105270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HEV0771730.1"
                     /translation="MSTKYLFIYNEIREKILCNKYTMNEQLPDEMTLAKQFACSRMTI
                     KKALDLLVSEGLIFRKRGQGTFVLSRGSSKRKLIVPERDIRGLTKISEDAHSTIDSRI
                     IHFKLEFANEFLAEKLQVALQSPVYNIYRLRIIDGKPYVLEQTYMSTDVIPGITEDIL
                     QKSIYNYIEGKLGLHIASATKILRASSSSENEQHYLQLLPTEPVFEVEQVAYLDNGTP
                     FEYSISRHRYDLFEFNSFALRHSS"
     gene            1304..2713
                     /locus_tag="VXE25_001271"
     CDS             1304..2713
                     /locus_tag="VXE25_001271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HEV0771731.1"
                     /translation="MKKKLVFPNLFWWGAASSGPQTEGQYGKVHENVMDYWFKTHPED
                     FFDNVGPLVASNFFHTYTEDFHLMKEIGVNSFRTSIQWSRLIKNLETGEPDPKGIAFY
                     NAIIEEAKKNQMDLVMNLHHFDLPVELLQKYGGWESKHVVELFVKFAKTAFTCFGDKV
                     HYWTTFNEPMVIPEAGYLYAFHYPNLKGKGKEAVQVIYNLNLASAKVIQLYRSLGLDG
                     KIGIILNLTPAYPRSNSPEDLEASRFTDDFFNKVFLNPAVKGTFPERLVKQLERDGVL
                     WSHTEKELQLMKSNTVDFLGVNYYHPKRVQAQANPEEYQTPWMPDQYFKEYEWPERRM
                     NPYRGWEIFPKAIYDIAMIVKKEYGNIPWFISENGMGVENEARFIGENGVIDDVYRIE
                     FYEEHLRWLHKAIEEGSHCFGYHAWTAFDCWSWNNAYKNRYGFISVDLETQKRTIKRS
                     GRWYRKVSDNNGFEVEIEE"
     gene            2731..4026
                     /locus_tag="VXE25_001272"
     CDS             2731..4026
                     /locus_tag="VXE25_001272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000798148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HEV0771732.1"
                     /translation="MKNSKFIDQFATFAGKLGNQIHLKTLRDAFVTVMPLYILAGLIV
                     LLNNTVFKWIFQGDTLTRFQYWGITIANGTLSISGMIIAVMVGYFLAKNRDFENPLAA
                     SMLSLVSLIVMMPNTVSVVPDGAKDAVNISGVLSFNNTGTGAMFAGVIVAIIATELFI
                     ELSNVKALQMNLGENIPPAVSRSFSVLLPVMTVISLFGVVSALLFNITGMNLISIITI
                     FIQEPIRHIGTSLIGVIIIYSLGNMLWLFGIHQAVIYSAILEPLLLINITENITAANN
                     GQAIPHIINLSQIQTFALMGGSGSTLCLLIATFLVSRNAVSKNVAKLSFGPGIFNINE
                     PVLFGYPIVYNISLAIPFITVPVLGILISYLATVTGFMSPAFIQVPWTTPVFLNAWLA
                     TAGDVRAVLVQFIIFALGVLLYIPFIKVNDKVVEQEMEG"
     gene            4031..4339
                     /locus_tag="VXE25_001273"
     CDS             4031..4339
                     /locus_tag="VXE25_001273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEV0771733.1"
                     /translation="MKQILLVCNAGMSTSMLVKKMQQSATERGIEISIQAKSMTEAKK
                     NIHEADVILIGPQIRYELLAVKEIAGNIPVDTIDMRDYGMMNGAKVLEQALEWIGEIR
                     "
     gene            4336..4644
                     /locus_tag="VXE25_001274"
     CDS             4336..4644
                     /locus_tag="VXE25_001274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000134125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HEV0771734.1"
                     /translation="MTEEMEYICFQLIANSGAAKSSFIEAIQLAKAGNLKEAKIKVEE
                     AEDSLVEAHKIHSNLIQKEATGEKIGFSLLFMHAEDQMASTEIIQLLSKEFIDLYQNK
                     "
     gene            complement(5511..8162)
                     /gene="adhE"
                     /locus_tag="VXE25_001275"
                     /gene_synonym="adhC"
     CDS             complement(5511..8162)
                     /gene="adhE"
                     /locus_tag="VXE25_001275"
                     /gene_synonym="adhC"
                     /EC_number="1.1.1.1"
                     /EC_number="1.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000763984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional acetaldehyde-CoA/alcohol
                     dehydrogenase"
                     /protein_id="HEV0771735.1"
                     /translation="MADKKTVTPEEKKLVAEKHVDELVQKALVALEEMRKLDQEQVDY
                     IVAKASVAALDAHGELALHAFEETGRGVFEDKATKNLFACEHVVNNMRHTKTVGVIEE
                     DDVTGLTLIAEPVGVVCGITPTTNPTSTAIFKSLISLKTRNPIVFAFHPSAQESSAHA
                     ARIVRDAAIAAGAPENCVQWITQPSMEATSALMNHEGVATILATGGNAMVKAAYSCGK
                     PALGVGAGNVPAYVEKSANIRQAAHDIVMSKSFDNGMVCASEQAVIIDKEIYDEFVAE
                     FKSYHTYFVNKKEKALLEEFCFGVKANSKNCAGAKLNADIVGKPATWIAEQAGFTVPE
                     GTNILAAECKEVGENEPLTREKLSPVIAVLKSESREDGITKARQMVEFNGLGHSAAIH
                     TADEELTKEFGKAVKAIRVICNSPSTFGGIGDVYNAFLPSLTLGCGSYGRNSVGDNVS
                     AINLLNIKKVGRRRNNMQWMKLPSKTYFERDSIQYLQKCRDVERVMIVTDHAMVELGF
                     LDRIIEQLDLRRNKVVYQIFADVEPDPDITTVNRGTEIMRAFKPDTIIALGGGSPMDA
                     AKVMWLFYEQPEVDFRDLVQKFMDIRKRAFKFPLLGKKTKFIAIPTTSGTGSEVTPFA
                     VISDKANNRKYPIADYSLTPTVAIVDPALVLTVPGFVAADTGMDVLTHATEAYVSQMA
                     SDYTDGLALQAIKLVFENLESSVKNADFHSREKMHNASTIAGMAFANAFLGISHSMAH
                     KIGAQFHTIHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRADEKYQDIARMLGLPA
                     STPEEGVESYAKAVYELGERIGIQMNFRDQGIDEKEWKEHSRELAFLAYEDQCSPANP
                     RLPMVDHMQEIIEDAYYGYKERPGRRK"
     gene            complement(8462..8872)
                     /locus_tag="VXE25_001276"
     CDS             complement(8462..8872)
                     /locus_tag="VXE25_001276"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000427064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771736.1"
                     /translation="MENLTNFYEKYRVYLTRPRLEILAVVTIVFCAVLVFFLNIPGKG
                     VLKLDNGTIVYDGSLVRGKMNGQGTITFQNGDQYTGGFNNGAFNGKGTFQSKEGWTYE
                     GDFVNGQAEGKGKLTTEQEVVYEGTFKQGVFQQK"
     gene            complement(8874..9302)
                     /locus_tag="VXE25_001277"
     CDS             complement(8874..9302)
                     /locus_tag="VXE25_001277"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000737444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="low molecular weight phosphotyrosine protein
                     phosphatase"
                     /protein_id="HEV0771737.1"
                     /translation="MKKLVFVCLGNICRSPMAEFVMKSMTDNYEIQSRATSSWEHGNP
                     IHKGTQGIFQQYEIPYDKNKTSLQISKEDFEAFDYIIGMDASNISDLRQMCPVDCQDK
                     IYSFSSESVPDPWYTGDFEETYRRVQEGCQAWLERLEKES"
     gene            complement(9349..9648)
                     /gene="yajC"
                     /locus_tag="VXE25_001278"
     CDS             complement(9349..9648)
                     /gene="yajC"
                     /locus_tag="VXE25_001278"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001069053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit YajC"
                     /protein_id="HEV0771738.1"
                     /translation="MNPNITFLIMLVGMMALMFFMQRSQKKQAQKRMESLNKLQKGYE
                     VITIGGLYGTVDEVDTEKGTIVLDVDGVYLTFELAAIKTVLPLKETASLEGAIEK"
     gene            complement(9765..11741)
                     /gene="tkt"
                     /locus_tag="VXE25_001279"
     CDS             complement(9765..11741)
                     /gene="tkt"
                     /locus_tag="VXE25_001279"
                     /EC_number="2.2.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004185329.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase"
                     /protein_id="HEV0771739.1"
                     /translation="MSNLSVNAIRFLGIDAINKANSGHPGVVMGAAPMAYSLFTKQLH
                     INPAQPNWINRDRFILSAGHGSMLLYALLHLSGFEDVSMDEIKSFRQWGSKTPGHPEF
                     GHTAGIDATTGPLGQGISTATGFAQAERFLAAKYNREGYNIFDHYTYVICGDGDLMEG
                     VSSEAASYAGLQKLDKLVVLYDSNDINLDGETKDSFTESVRDRYNAYGWHTALVENGT
                     DLEAIHAAIETAKASGKPSLIEVKTVIGYGSPNKQGTNAVHGAPLGADETASTRQALG
                     WDYEPFEIPEQVYADFKEHVADRGASAYQAWTKLVADYKEAHPELAAEVEAIIDGRDP
                     VEVTPADFPALENGFSQATRNSSQDALNVVAAKLPTFLGGSADLAHSNMTYIKTDGLQ
                     DDTNRLNRNIQFGVREFAMGTILNGMALHGGLRVYGGTFFVFSDYVKAAVRLSALQGL
                     PVTYVFTHDSIAVGEDGPTHEPVEHLAGLRAMPNLNVFRPADARETQAAWYLAVTSEK
                     TPTALVLTRQNLTVEDGTDFDKVAKGAYVVYENAADFDTILIATGSEVNLAVSAAKEL
                     ASQGEKIRVVSMPSTDVFDKQDAAYKEEILPNAVRRRVAVEMGASQNWYKYVGLDGAV
                     LGIDTFGASAPAPKVLAEYGFTVENLVKIVRNLK"
     gene            complement(11855..12946)
                     /gene="ulaG"
                     /locus_tag="VXE25_001280"
     CDS             complement(11855..12946)
                     /gene="ulaG"
                     /locus_tag="VXE25_001280"
                     /EC_number="3.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-ascorbate 6-phosphate lactonase"
                     /protein_id="HEV0771740.1"
                     /translation="MPNVKEITRESWILATFPEWGTWLNEEIEEEVVPEGNFAMWWLG
                     NCGTWIKTPAGANVVMDLWSNRGKSTKKVKDMVRGHQMANMAGVRKLQPNLRVQPMVI
                     DPFAINELDYYLVSHFHSDHIDPYTAAAILNNPKLEHVKFIGPYHCGRIWEGWGVPKE
                     RIIVVKPGDTIELKDMKIHAVESFDRTCLVTLPVNGADETGGELAGLAVTDEEMAQKA
                     VNYIFETPGGTIYHGADSHFSNYFAKHGKDFKIDVALNNYGENPVGIQDKMTSIDLLR
                     MAENLRTKVIIPVHYDIWSNFMASTNEILELWKMRKDRLQYDFHPFIWEVGGKYTYPQ
                     DQHLVEYHHPRGFDDCFEQDSNIQFKALL"
     gene            complement(13121..14731)
                     /locus_tag="VXE25_001281"
     CDS             complement(13121..14731)
                     /locus_tag="VXE25_001281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242099.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HEV0771741.1"
                     /translation="MVLDKASCDLLQYLMDQETSKTIMAISKDLKESRRKIYYHIDKI
                     NAALGDEALHIISIPRIGIHLTEEQRDACCKLLSEVDSYDYIMSAHERMMIMLLWIGI
                     SKERITIEKLIELTEVSRNTVLNDLNSIRYQLTLEQYQVILQVSKSQGYHLHAHPLNK
                     IQYLQSLLYHIFMEENATFVSILEDKMKERLDDECLLSVEMNQFFKEQVPLVEQDLGK
                     KINHHEITFMLQVLPYLLLSCHNVEQYQERHQDIEKEFSLIRKRIEYQVSKKLGERLF
                     QKFEISLSGLEVSLVAVLLLSYRKDLDIHAESDDFRQLKLALEEFIWYFESQIRMEIE
                     NKDDLLRNLMIHCKSLLFRKTYGIFSKNPLTKQIRSKYGELFLVTRKSAEILEGAWFI
                     RLTDDDIAYLTIHIGGFLKYTPSSQKNMKKVYLVCDEGVAVSRLLLKQCKLYFPNEQI
                     DTVFTTEQFKSVEDIAQVDVVITTNDDLDSRFPILRVNPILEAEDILKMLDYLKHNIF
                     RNKSKSFSENLSSLISSYIVDSKLASKF"
     gene            complement(14910..15614)
                     /locus_tag="VXE25_001282"
     CDS             complement(14910..15614)
                     /locus_tag="VXE25_001282"
                     /EC_number="5.1.3.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001077552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-ribulose-5-phosphate 4-epimerase"
                     /protein_id="HEV0771742.1"
                     /translation="MNQVINAMRKRVCDANQSLPKHGLVKFTWGNVSEVNRELGVIVI
                     KPSGVDYDELTPENMVVTDLDGKILEGDLRPSSDLPTHVQLYKAWSEIGSVVHTHSTE
                     AVAWAQAGRDIPFYGTTHADYFYGSIPCARSLTKDEVEVAYEKDTGLVIVEEFEHRGL
                     NPVEVPGIVVRNHGPFTWGKNPENAVYHSVVLEEVSKMNRFTEQINPRVGPAPQYILE
                     KHYQRKHGPNAYYGQK"
     gene            complement(15616..16479)
                     /locus_tag="VXE25_001283"
     CDS             complement(15616..16479)
                     /locus_tag="VXE25_001283"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000252119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-ribulose-5-phosphate 3-epimerase"
                     /protein_id="HEV0771743.1"
                     /translation="MVRPIGIYEKATPTHFTWLERLNFAKELGFDFVEMSIDERDERL
                     ARLDWSKEERLEVVKAIYETGVRIPSICFSGHRRYPLGSKDPVLEEKSLELMKKCIEL
                     AQDLGVRTIQLAGYDVYYEEKSPQTRQRFIKNLRKACDWAEEAQVVLAIEIMDDPFIN
                     SIEKYLAIEKEIDSPFLFVYPDIGNVSAWHNDIYSEFYLGHHAIAALHLKDTYAVTES
                     SKGQFRDVPFGQGCVKWEEAFDILKETNYNGPFLIEMWSENCETVEETRAAVQEAQAF
                     LYPLIKKAGLM"
     gene            complement(16483..17148)
                     /locus_tag="VXE25_001284"
     CDS             complement(16483..17148)
                     /locus_tag="VXE25_001284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-keto-L-gulonate-6-phosphate decarboxylase
                     UlaD"
                     /protein_id="HEV0771744.1"
                     /translation="MTKRIPNLQVALDHSDLQGAIKAAVSVGQEVDIIEAGTVCLLQV
                     GSELAEVLRSLFPDKIIVVDTKCADAGGTVAKNNAVRGADWMTCICCATIPTMEAALK
                     AIKTERGERGEIQIELYGDWTFEQAQLWLDAGISQAIYHQSRDALLAGETWGEKDLNK
                     VKKLIDMGFRVSVTGGLDVDTLKLFEGVDVFTFIAGRRITEAADPAGAARAFKDEIKR
                     IWG"
     gene            complement(17165..17650)
                     /locus_tag="VXE25_001285"
     CDS             complement(17165..17650)
                     /locus_tag="VXE25_001285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEV0771745.1"
                     /translation="MNLKQALIDNDSIRLGLEANDWKEAVKVAVDPLIESGAILPEYY
                     DAIIESTEEYGPYYILMPGMAMPHARPEAGVQSDAFSLITLQNPVVFSDGKEVSVLLA
                     LAATSSKIHTSVAIPQIIALFELEDSIARLQACQTKEDVLAMIEESKDSPYLEGLDLE
                     S"
     gene            complement(17730..18008)
                     /locus_tag="VXE25_001286"
     CDS             complement(17730..18008)
                     /locus_tag="VXE25_001286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000241469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEV0771746.1"
                     /translation="MVKVLAACGNGMGSSMVIKMKVENALRKLNQTDFTVNSCSVGEA
                     KGLAVGYDIVIASLHLIQELEGRTNGKLIGLDNLMDDKEITEKLSQAL"
     gene            complement(18031..19488)
                     /locus_tag="VXE25_001287"
     CDS             complement(18031..19488)
                     /locus_tag="VXE25_001287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS ascorbate transporter subunit IIC"
                     /protein_id="HEV0771747.1"
                     /translation="MEVVSSVLNWFSSNILQNPAFFVGLLVLIGYALLKKPAHDVFSG
                     FVKATVGYMLLNVGAGGLVTTFRPILAALNYKFQIGAAVIDPYFGLAAANNKIAAEFP
                     DFVGTATTALLIGFGINILLVALRKITKVRTLFITGHIMVQQAATVSLMVLFLVPQLR
                     NAYGTAAIGIICGLYWAVSSNMTVEATQRLTGGGGFAIGHQQQFAIWFVDKVAGRFGK
                     KEESLDNLKLPKFLSIFHDTVVASATLMLVFFGAILLILGPDIMSNKEVITSGTLFNP
                     AKQDFFMYIIQTAFTFSVYLFVLMQGVRMFVSELTNAFQGISNKLLPGSFPAVDVAAS
                     YGFGSPNAVLSGFTFGLIGQLITIVLLIVFKNPILIITGFVPVFFDNAAIAVYADKRG
                     GWKAAVILSFISGVLQVALGALCVALLDLASYGGYHGNIDFEFPWLGFGYIFKYLGIV
                     GYVLVCLFLLVIPQLQFAKAKDKEKYYNGEVQEEA"
     gene            complement(19619..20242)
                     /locus_tag="VXE25_001288"
     CDS             complement(19619..20242)
                     /locus_tag="VXE25_001288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000932659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease P"
                     /protein_id="HEV0771748.1"
                     /translation="MLNKIRDYLDFSGLQYRSPDKAGAEREKMLAFRHKGQEARKAFT
                     ELAKAFQASHPEWQLQQTSQWMNQAQRLRPHFWVYLQRDGQVTEPMMALRLYGTSTDF
                     GISLEVSFIERKKDEQTLGKQAKILDIPTVKGIYYLTYSNGQSQRWEANEEKRRTLRE
                     KVRSQEVRKVLVKVDVPMTENSSEEEIVEGLLKSYSKILPYYLATRK"
     gene            complement(20293..21279)
                     /locus_tag="VXE25_001289"
     CDS             complement(20293..21279)
                     /locus_tag="VXE25_001289"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein jag"
                     /protein_id="HEV0771749.1"
                     /translation="MVVFTGSTVEEAIQKGLKELDIPRMKAHIKVISREKKGFLGLFG
                     KKPAQVDIEAISETTVVKANQQVVKGVPKKINDLNEPVKTVSEETVDLGHVVDAIKKI
                     EEEGQGISDEVKAEILKHERHASTILEETGHIEILNELQIEEAMREEAGADDLETEQD
                     QTENQDLKEMGLKVEQSYDIAQVATDVTAYVQTIIDDMDVEATLSNDYNRRSINLQID
                     TNEPGRIIGYHGKVLKALQLLAQNYLYNCYSRTFYITINVNDYVEHRAEVLQTYAQKL
                     AIRVLEEGRSHQTDPMSNSERKIIHRIISRMDGVTSYSEGDEPNRYVVVDTE"
     gene            complement(21298..22122)
                     /locus_tag="VXE25_001290"
     CDS             complement(21298..22122)
                     /locus_tag="VXE25_001290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000727905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertase YidC"
                     /protein_id="HEV0771750.1"
                     /translation="MKKKLKLTSLLGLSLLIMTACATNGVTSDITAESADFWSKLVYF
                     FAEIIRFLSFDISIGVGIILFTVLIRTVLLPVFQVQMVASRKMQEAQPRIKALREQYP
                     GRDMESRTKLEQEMRKVFKEMGVRQSDSLWPILIQMPVILALFQALSRVDFLKTGHFL
                     WINLGSVDTTLVLPILAAVFTFLSTWLSNKALSERNGATTAMMYGIPVLIFIFAVYAP
                     GGVALYWTVSNAYQVLQTYFLNNPFKIIAEREAVVQAQKDLENRKRKAKKKAQKTK"
     gene            complement(22097..22468)
                     /gene="rnpA"
                     /locus_tag="VXE25_001291"
     CDS             complement(22097..22468)
                     /gene="rnpA"
                     /locus_tag="VXE25_001291"
                     /EC_number="3.1.26.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000739244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease P protein component"
                     /protein_id="HEV0771751.1"
                     /translation="MKKNFRVKREKDFKAIFKEGTSFANRKFVVYQLENQKNHFRVGL
                     SVSKKLGNAVTRNQIKRRIRHIIQNAKGSLVEDVDFVVIARKGVETLGYAEMEKNLLH
                     VLKLSKIYREGNGSEKETKVD"
     gene            complement(22617..23807)
                     /locus_tag="VXE25_001292"
     CDS             complement(22617..23807)
                     /locus_tag="VXE25_001292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000167779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetate kinase"
                     /protein_id="HEV0771752.1"
                     /translation="MTKTIAINAGSSSLKWQLYLMPEEKVLAKGLIERIGLKDSISTV
                     KFDGRSEQQILDIENHTQAVKILLDDLIRFDIIKAYDEITGVGHRVVAGGEYFKESTV
                     VEGDVLEKVEELSLLAPLHNPANAAGVRAFKELLPDITSVVVFDTSFHTSMPEKAYRY
                     PLPTKYYTENKVRKYGAHGTSHQFVAGEAAKLLGRPLEDLKLITCHIGNGGSITAVKA
                     GKSVDTSMGFTPLGGIMMGTRTGDIDPAIIPYLMQYTEDFNTPEDISRVLNRESGLLG
                     VSANSSDMRDIEAAVAEGNHEASLAYEMYVDRIQKHIGQYLAVLNGADAIVFTAGVGE
                     NAENFRRDVISGISWFGCDVDDEKNVFGVTGDISTEAAKIRVLVIPTDEELVIARDVE
                     RLKK"
     gene            complement(23858..24811)
                     /locus_tag="VXE25_001293"
     CDS             complement(23858..24811)
                     /locus_tag="VXE25_001293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000345081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HEV0771753.1"
                     /translation="MDFEKIEQAYTYLLENVQVIQSDLATNFYDALVEQNSIYLDGET
                     ELNQVKDNNQALKRLALRKEEWLKTYQFLLMKAGQTEPLQANHQFTPDAIALLLVFIV
                     EELFKEEEITILEMGSGMGILGATFLTSLDKKVDYLGMEVDDLLIDLAASMADVIGLQ
                     AGFVQGDAVRPQMLKESDVVISDLPVGYYPDDAVASRHQVASSQEHTYAHHLLMEQGL
                     KYLKSDGYAIFLAPSDLLTSPQSDLLKEWLKEEASLVAMISLPENLFANAKQSKTIFI
                     LQKKNEIAVEPFVYPLASLQDASVLMKFKENFQKWTQGTEI"
     gene            complement(24872..25464)
                     /locus_tag="VXE25_001294"
                     /pseudo
     CDS             complement(24872..25464)
                     /locus_tag="VXE25_001294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000679792.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
     gene            complement(25567..26013)
                     /locus_tag="VXE25_001295"
     CDS             complement(25567..26013)
                     /locus_tag="VXE25_001295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001851880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein ComGF"
                     /protein_id="HEV0771754.1"
                     /translation="MWKKKKVKAGVLLYAVTMAAIFSLLLQFYLNRQVAHYQDYALNK
                     EKLVAFAMAKRTKDKVEQESGEQVFNLGQVSYQNKKTGLVTRVRTDKSQYEFLFSSVK
                     IKEEKTDKKEEVVTDSSEKAEKKNQKRSLKRKRIHSQFNYNALNPE"
     gene            complement(25991..26452)
                     /locus_tag="VXE25_001296"
     CDS             complement(25991..26452)
                     /locus_tag="VXE25_001296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000250539.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein ComGF"
                     /protein_id="HEV0771755.1"
                     /translation="MVQNSCWQSKSHKVKAFTLLESLLALIVISGGLLLFQAMSQLLI
                     SEVRYQQQSEQKEWLLFVDQLEVELDRSQFEKVEGNRLYMKQDGKDIAIGKSKSDDFR
                     KTDASGRGYQPMVYGLKSAQITEDNQLVHFRFQFQKGLEREFIYRVEKEES"
     gene            complement(26415..26675)
                     /locus_tag="VXE25_001297"
     CDS             complement(26415..26675)
                     /locus_tag="VXE25_001297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000601743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771756.1"
                     /translation="MILLEAVVALAIFASIATLLLGQIQKNRQEEAKILQKEEVLRVA
                     KMALQTGQNQVSINGVEIQVFSSEKGLEVYHGSEQLLAIKEP"
     gene            complement(26680..27159)
                     /locus_tag="VXE25_001298"
     CDS             complement(26680..27159)
                     /locus_tag="VXE25_001298"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931802.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II secretion system protein"
                     /protein_id="HEV0771757.1"
                     /translation="MDASRKNRLKPIKNTMINKILVKSLKIKAFTMLESLLVLGLVSI
                     LALGLSGSVQSTFAAVEEQIFFMEFEELYRETQKRSVASQQKTSLNLDGQMISNGSQK
                     LPVPKGIQAPSGQSITFDRAGGNSSLAKVEFQTSKGAIRYQLYLGNGKIKRIKETKN"
     gene            complement(27077..27340)
                     /locus_tag="VXE25_001299"
     CDS             complement(27077..27340)
                     /locus_tag="VXE25_001299"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000738628.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein ComGC"
                     /protein_id="HEV0771758.1"
                     /translation="MLVVLLIISVLFLLFVPNLTKQKEAVNDKGKAAVVKVVESQAEL
                     YSLEKNEDASLRKLQDDGRITEEQAKAYKEYHDKQNTSQIVKD"
     gene            complement(27342..27599)
                     /locus_tag="VXE25_001300"
     CDS             complement(27342..27599)
                     /locus_tag="VXE25_001300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771759.1"
                     /translation="MKILNIELANVEQTDLGFEHWVDVTYQVPILKNEYTVKLLLLME
                     CRIEDQEVIEYLVSTWKYRDLVLHSVKMYEIEKSESFTILD"
     gene            complement(27831..>28109)
                     /locus_tag="VXE25_001301"
     CDS             complement(27831..>28109)
                     /locus_tag="VXE25_001301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="autolysin"
                     /protein_id="HEV0771760.1"
                     /translation="NWYWFDNSGEMATGWKKIAEKWYYFDVEGAMKTGWVKYKDTWYY
                     LDAKEGAMVSNAFVQSADGTGWYYLKPDGTLVDKPDFTVEPDGLIAVK"
BASE COUNT         8353 a         5883 c         5038 g         8835 t
ORIGIN      
        1 aaatgattat gatttagaat ttatttaata tattaaaaga agatatgaac aaataaattg
       61 ggagattgaa attcatttct agcaatttgt tagaagtcac agtctactat tctaaccaca
      121 gtatactata tgtgttacaa gaaaagactc aaaaacttct cgtcagtgta agaatgtttg
      181 aaacactatt taaaactaaa taactataag aagtagatca ggtgaacaat ttcagtacct
      241 actctataag ctatacgaag atatttttca acatgatgga tacaacgatc actcttttaa
      301 agccatctta tttagaaaag agaaaccatt taagcataga tgggaccttc ttgccctgtt
      361 ttaaattttt cttaaactag agtctgtaaa agattggctt cattttcaca ttttctccta
      421 ggaggaatgt cgtaatgcaa aagaattaaa ttcaaataaa tcatagcgat gacgactaat
      481 cgagtactca aacggagttc cgttatccaa ataagccact tgttctactt caaataccgg
      541 ttccgttgga aggagctgca agtaatgttg ctcattttct gaactagaag aagctcgtaa
      601 gatttttgta gcactggcaa tatgcaatcc taactttcct tcaatgtaat tgtaaatcga
      661 tttttgtaaa atatcttcag taatacctgg aataacatcg gtactcatat aagtttgttc
      721 cagaacataa ggtttaccgt caataatacg caggcggtaa atattataaa ctggactctg
      781 caaagcgacc tgtagttttt ctgctaaaaa ttcatttgca aattctaatt tgaagtgaat
      841 aatcctcgag tcaattgtag aatgagcatc ttcagatatt tttgtcagtc cccggatatc
      901 tctttctgga acgattaatt ttctttttga gctgccacga gagagaacaa aggttccctg
      961 cccacgtttt ctaaaaatta agccctcaga aactaacaag tctaaagctt ttttgatcgt
     1021 cattcgacta caggcaaact gtttagctaa tgtcatttca tcaggcaatt gttcgttcat
     1081 ggtatattta ttacaaagaa tcttttcacg aatctcattg taaataaata aatattttgt
     1141 actcatttaa tctggttctc tctataatat tctaatagta gtataacaaa gttcaagaaa
     1201 tgaggcaaac acaagatatg tatcaacaat ttttaaaaat gtctagacaa attttaaaat
     1261 tatgctatac tttatgtata gaataataga aaggaggttg agcatgaaaa aaaagttagt
     1321 atttcctaat ctgttttggt ggggagctgc ttctagcgga cctcagacag aaggtcaata
     1381 tggaaaagta catgaaaatg tgatggacta ctggttcaaa acgcatccag aagatttttt
     1441 cgataatgtc ggacctcttg tagccagtaa cttttttcat acttacaccg aagatttcca
     1501 cttgatgaag gaaattggag ttaattcttt ccgcacttcc atccaatgga gtcgactcat
     1561 caagaattta gagacaggtg agcctgatcc aaaaggtatt gctttctaca atgccatcat
     1621 tgaagaagct aaaaagaacc agatggatct tgtgatgaat ttacatcatt ttgatttacc
     1681 agtggaactt cttcaaaaat acggtggttg ggaaagcaaa catgtagtgg agttattcgt
     1741 gaagtttgcc aagactgctt tcacatgctt tggagataag gttcattact ggacaacttt
     1801 caatgagcca atggtcattc cagaagcagg atacttatat gctttccatt atccaaatct
     1861 aaaaggaaag ggaaaagagg ccgtacaagt catctataat ctaaaccttg ctagtgcaaa
     1921 agtgattcaa ctatatcgct cattaggact tgatggaaag attgggatta ttttaaactt
     1981 gacacctgct tatccaagaa gtaattctcc agaagactta gaagcaagtc gatttacaga
     2041 tgacttcttt aacaaagtct tcttgaatcc agctgttaaa ggaactttcc cagaaagatt
     2101 ggtaaaacag ctagagagag atggcgtgtt atggagtcat accgaaaaag agcttcaact
     2161 gatgaaatca aatacggttg attttcttgg agtaaactac taccatccaa aacgtgttca
     2221 agcacaagca aatcctgagg aatatcagac gccctggatg ccagaccaat acttcaaaga
     2281 gtatgaatgg ccggagcgtc gcatgaatcc atatcgtggt tgggaaattt ttccgaaagc
     2341 catttatgat attgctatga ttgtgaagaa agaatatggt aatattccat ggtttatcag
     2401 tgaaaacgga atgggtgttg aaaacgaagc acggtttatc ggtgaaaatg gagttatcga
     2461 tgacgtgtat cgtattgaat tttatgaaga acatttaaga tggctacata aagccattga
     2521 agagggaagt cactgttttg gataccacgc ttggaccgca tttgattgct ggtcttggaa
     2581 taatgcatat aagaatcgtt acggatttat ctccgttgat ttagaaacgc aaaagagaac
     2641 catcaagaga tcaggaagat ggtatcgcaa agtaagtgac aataacggtt ttgaagtaga
     2701 aattgaggag taaagagagg agatattcag atgaaaaact caaaatttat agatcaattt
     2761 gccacctttg ctggtaaact agggaaccaa attcatttaa aaaccctaag agatgcattc
     2821 gtaacagtaa tgccattata tattttggca ggtttaatcg ttcttttgaa caacacggta
     2881 tttaagtgga ttttccaagg ggatacatta acaagattcc aatattgggg aataacaatt
     2941 gcaaacggta ctttaagtat ttcaggtatg attattgctg taatggttgg ttatttctta
     3001 gctaaaaaca gagatttcga aaacccgtta gcagcatcaa tgctatcatt agtttcttta
     3061 attgtgatga tgccaaatac agtttctgta gttcctgacg gagcaaaaga tgcggtaaac
     3121 atttcaggtg ttctttcatt caacaacaca ggtacaggcg caatgttcgc cggggttatc
     3181 gtagcgatta ttgcaacaga attattcatt gaattatcaa acgttaaagc tttacaaatg
     3241 aaccttggtg aaaatattcc accagctgtt agtagatcat ttagcgtatt acttccagtc
     3301 atgaccgtca tctccttatt tggggttgtt tcagcattat tattcaatat aactggaatg
     3361 aacttaatct caatcattac aatctttatt caagaaccaa ttcgtcatat tggtacaagc
     3421 ttaatcgggg tcattattat ttactcttta ggaaatatgt tatggctatt tggtattcac
     3481 caagcagtta tttacagtgc catcctagaa ccattactat taattaacat tactgaaaac
     3541 atcactgcag caaataatgg acaagccatt ccacacatca tcaacttatc acaaatacaa
     3601 acattcgctt taatgggtgg tagtggatct acattatgtt tattaatagc aacattctta
     3661 gtaagtcgca atgctgtttc taaaaacgtg gctaaattat cttttggacc tggtatcttc
     3721 aatatcaatg aaccagtatt attcggttac ccaatcgttt ataacatttc attagctatt
     3781 ccatttatca cagttccagt acttggtatt ttaatcagct acttagcaac agttacagga
     3841 ttcatgagtc ctgcatttat acaagttcct tggactacac cagtattctt aaatgcatgg
     3901 ttagcaacag caggggacgt gagagcagtt ctagttcaat tcatcatctt tgcacttgga
     3961 gttcttctat acattccatt tatcaaagtt aatgacaaag ttgttgaaca agaaatggaa
     4021 ggttaatatt atgaaacaaa ttttattagt atgtaatgcg ggaatgtcga caagtatgct
     4081 tgttaaaaaa atgcaacaaa gtgcgactga acgtgggatt gaaatttcta tccaagcaaa
     4141 atcaatgaca gaagctaaaa aaaatatcca tgaagcagat gtcattctaa ttgggccaca
     4201 aattcgttat gagttacttg ctgtgaaaga aattgcagga aatatccctg tagataccat
     4261 tgatatgcgg gattacggaa tgatgaatgg agcaaaagtt ctggaacaag cacttgaatg
     4321 gataggagaa ataagatgac agaagaaatg gaatatatct gttttcagct cattgccaat
     4381 agtggagcag ccaaatcatc ctttattgaa gccatccaac tagctaaggc aggaaattta
     4441 aaagaagcga aaattaaagt tgaagaagcg gaagactcct tagtagaagc gcacaagatt
     4501 cactccaatc tcatacaaaa agaagctact ggagaaaaaa taggattctc cttgctattt
     4561 atgcatgcag aagaccaaat ggcttcaaca gagattattc agttgctatc taaagaattc
     4621 atcgatctct atcaaaataa ataggaacac tgtcgttccc atctgtcttt attaatgacg
     4681 actacattgt aggaacctcc aaaagttgga caaaatgatt gaaaggattg gatcctgcat
     4741 tacacaagat ccaatccttt tcttttactc tagtttttat aatatgttga atctagaata
     4801 gtccactgca gtttctaaaa aattgctgga aatagatgtt aagctccaat ttatttgttt
     4861 atatcttatt tcagtttact atactagctt attattctag tgaaaaattg aatgagccac
     4921 tatttattta atatgtatga tgagggaatg actcaaaaac ttcttgtcga tataagaata
     4981 tctgagatag tattttaaaa cgaaaggact ataaaagctc atttccttcg cacttatttt
     5041 atagagatct atcattatac tctttagaaa tcaaaaagca acacaccttg tcatcgtttt
     5101 atcgtaaatc tgttaatgag ggggctagtc ttatctgcaa tctcaaatca gtgttttgag
     5161 ctgaatggca ctcgttttct agtttgctct ttgattttaa ttgggcctta gtaaatacta
     5221 ctcttaaatt aaactatagt gaattgaaat aagatgtaaa caactctatc aggaaagtaa
     5281 aattaatttc tataaatgtt ttagaagcag atgtgtacta ttctagtttc aatctgctat
     5341 atattttgtt tctattctag tttttcaaaa agggcaaaaa ggcctcaaca tcataaaaag
     5401 gcatcctatc aggtattcaa aaaccttgat aggatgcctt ttatcataga aaaattactg
     5461 gatctttccc tcaaattgag tttttgtctt gcttctagac tgataaacaa ttatttacgg
     5521 cgtcctggtc tttctttgta gccatagtat gcatcttcga tgatttcttg catatggtct
     5581 accattggaa gacgtgggtt agctggtgaa cattggtctt cataagccag gaaggctaat
     5641 tcacgagaat gttctttcca ttctttttcg tcaattcctt ggtctctaaa attcatttgg
     5701 atcccaatac gttcaccgag ttcgtagaca gcttttgcgt aagattcaac cccttcttct
     5761 ggagtagaag ctggaagtcc aagcatgcgt gcgatatctt ggtatttttc atctgcacgg
     5821 tagtagttgt acttaggcca tgttgctgtc ttagctggac gtgtaccgtt gtaacggata
     5881 acgtacggaa gcaagatagc atttgtacga ccgtggattg tgtggaattg cgcaccaatc
     5941 ttatgggcca ttgagtgaga aatacctaag aaggcattgg caaaggccat accagcgatt
     6001 gttgaagcgt tatgcatttt ctcacgtgag tggaagtctg cattcttaac tgagctttcg
     6061 agattttcaa agaccaattt aatggcttga agtgctaaac catcagtgta gtcactagcc
     6121 atttgtgata catatgcttc tgttgcgtga gtcaatacgt ccataccagt atcagcagca
     6181 acaaatcctg gaactgtcaa taccaaagca ggatctacga ttgccacagt tggtgtcaat
     6241 gagtagtcag cgattgggta tttacggttg tttgctttat cagagataac ggcaaatggt
     6301 gttacttcag atcctgtacc agatgtagtt ggaatcgcga tgaatttagt cttcttacca
     6361 agcaatggga acttgaaggc acgtttacgg atatccatga atttttggac aaggtcacgg
     6421 aagtccactt ctggttgctc gtagaagagc cacattactt tggcagcatc cattggagac
     6481 ccaccaccga gtgcgatgat ggtatctggt ttgaaggcac gcataatctc agtaccacgg
     6541 tttacagttg tgatatctgg atccggttct acatccgcaa agatttggta aacaacctta
     6601 ttgcgacgaa ggtccagttg ttcgatgata cgatcaagga aaccaagctc taccatggca
     6661 tggtcagtaa cgatcatgac acgttcaacg tcacgacatt tttgaaggta ttgaattgaa
     6721 tcacgttcaa agtatgtttt tgaaggaagt ttcatccatt gcatgttatt tctccgtctt
     6781 ccgacttttt tgatattcaa gaggttaatg gcactaacgt tatccccaac tgagttgcgt
     6841 ccgtaagaac cacatccaag tgtcaatgat ggcaagaagg cattgtaaac gtccccgata
     6901 ccaccaaaag tagaaggtga gttacagata acacgaatag ctttaacagc tttaccaaat
     6961 tctttagtca attcttcgtc agctgtgtgg atagctgctg agtgtccaag accgttaaat
     7021 tcaaccattt gacgagcctt agtaatacca tcttcacggc tttcagattt caaaactgca
     7081 ataactggtg acaatttttc acgagtcaat ggctcatttt cgccaacttc tttacattct
     7141 gcagcaagaa tgtttgttcc ttctggaact gtaaatcctg cttgttctgc aatccaagtt
     7201 gctggtttac caacgatgtc agcgttcaat tttgcaccag cacagttttt gctgtttgct
     7261 ttgacgccga agcagaactc ttcaagaaga gctttttctt ttttgtttac aaagtaagtg
     7321 tggtaagatt tgaactctgc tacaaattca tcgtaaattt ctttatcaat gataactgct
     7381 tgttcagatg cacagaccat accgttatca aatgatttag acatgacgat atcgtgtgct
     7441 gcttgacgaa tgtttgctga tttttcaaca taagctggaa cgtttccggc acctacccca
     7501 agagctggtt taccacatga ataagccgcc ttaaccatgg cattaccacc tgttgcaagg
     7561 attgtcgcaa caccttcgtg gttcataagg gcacttgttg cttccataga tggttgagta
     7621 atccattgca cacagttttc aggagcacca gctgcgatag ctgcatcgcg gacgatacga
     7681 gctgcatgag cagatgattc ttgtgctgat ggatggaagg caaagacgat tgggttacgt
     7741 gtcttcaatg aaatcaatga tttgaagatt gctgttgatg ttgggtttgt tgttggagta
     7801 ataccacaaa caacaccaac tggttcagca ataagagtca atcctgttac atcgtcttct
     7861 tcgataacgc caactgtctt agtgtgacgc atgttgttta ctacgtgttc acaggcaaac
     7921 aagttcttag ttgctttatc ttcaaataca ccacgtcctg tttcttcaaa ggcatgtaaa
     7981 gccaattctc cgtgggcatc caaagctgct actgatgctt tggcaacgat gtagtcaact
     8041 tgctcttgat ccaatttacg catttcttca agggcaacta gagctttttg aaccaactca
     8101 tctacgtgtt tttcagcaac gagtttcttt tcctctggtg tcacagtttt tttatcagcc
     8161 atattttcct ccatagcttt caaggatcga tatcctttgt taattttttc acaagtttat
     8221 tataacgcat tatttcaact ttgtaaacag tttcataaac atttcacaaa gaatttttaa
     8281 actcttgtga aacttttctc attttctttt cttatcaggt tttatctttg aagtttgtga
     8341 aatttatttc aaatattttt tatttcacaa acttgcttgg aagagggatt tggaaagaaa
     8401 gggatttaca ggtaagcgct taccttgtaa ttctaataat acctcctttg ataaggaggc
     8461 tttatttttg ttgaaaaacg ccttgtttaa aagttccttc ataaacgact tcttgttctg
     8521 ttgttagttt cccttttcct tcagcctgac catttacaaa atcaccttcg taggtccagc
     8581 cttctttaga ttgaaaggta ccttttccgt tgaaggctcc attgttgaag ccacctgtat
     8641 attggtctcc attttggaag gtaatggtac cttggccatt cattttaccg cggacaagac
     8701 tgccatcata aacaatcgtt ccattatcga gttttaagac accttttcct ggaatattta
     8761 gaaaaaagac gagtacagca cagaaaacaa tggtaactac tgccaaaatc tctaaacgtg
     8821 gacgagtcag ataaacacga tacttttcgt aaaaattcgt aagattttcc accttaactc
     8881 tccttttcta aacgttctaa ccaagcttga cagccctctt gaacacgtcg ataggtttct
     8941 tcaaaatctc ctgtatacca agggtctgga acactttcag atgaaaatga gtaaatctta
     9001 tcttgacagt ctactggaca catctgacgt aagtcagaaa tatttgaagc gtccattccg
     9061 ataatataat caaaggcttc aaaatcttcc ttactaatct gaagcgatgt cttgttcttg
     9121 tcataaggaa tctcatactg ttgaaaaatt ccctgagtcc ccttatgaat cggattgcca
     9181 tgttcccaag aggaagttgc tcgactttgg atttcgtagt tatctgtcat tgatttcata
     9241 acaaactcgg ccatagggct acggcaaata tttcccagac agacaaagac taattttttc
     9301 atcccatttc ctttctttta tagaaaaacg ggagttcgtg atcccgtctt atttttcaat
     9361 tgcgccttct agtgaagctg tttctttcag cggtaatact gtcttgatag cagctagttc
     9421 aaaagttaag taaactccat ctacgtcaag aactattgtt cccttctccg tatctacttc
     9481 atcgactgtt ccataaagtc caccgattgt aatcacttca tagccttttt gtagtttatt
     9541 taagctttcc atacgctttt gagcttgttt cttttgagaa cgttgcataa agaacatcaa
     9601 ggccatcata cctacaagca tgattaaaaa agtaatattt ggattcattg ttttctcctt
     9661 tgtcttttac ataggactac tatatcaaat tttagctact tttacaagat tgtaccttac
     9721 ttttctggta agaaaaacca gagcttacgc cctgattttt aggattattt caagtttcga
     9781 acaattttta caagattttc tacagtaaag ccatattctg ccaatacttt tggtgctggg
     9841 gcagaggctc cgaaggtatc aatacctaga acggcaccat cgagaccaac atatttgtac
     9901 cagttttgac ttgcacccat ttcgactgca acacgacggc ggactgcatt tggaagaatc
     9961 tcttccttgt aagctgcatc ttgtttatca aagacatctg tagatggcat gctgactacg
    10021 cggatttttt cgccttgact agccaattct ttagcagctg agacagcaag attaacctct
    10081 gaacctgtcg caatcaagat ggtatcaaag tcggctgcat tttcatatac aacataagca
    10141 cctttagcaa ccttgtcgaa gtctgttcca tcttcaacag tcaagttttg acgtgtcaag
    10201 acaagggcag ttggtgtttt ctcacttgtc actgcaaggt accaagctgc ttgcgtttca
    10261 cgcgcatctg ctggacggaa aacatttaga tttggcatag cacgaagacc tgctaaatgc
    10321 tcaaccggtt cgtgagtcgg accatcttcc ccaactgcga ttgaatcatg ggtaaagaca
    10381 taagtcacag gaagtccttg taaggctgac aagcggacag ctgccttcac atagtcagag
    10441 aagacgaaga aagttccacc gtatacacga agtccaccat gaagggccat cccgttcaag
    10501 attgttccca ttgcaaattc acgaacacca aactgaatgt tacgattcaa gcgattggta
    10561 tcgtcttgaa gtccatccgt cttgatataa gtcatgtttg agtgagcaag gtcagctgat
    10621 ccacctagga aggttggtaa tttagctgcc acaacattca aggcatcttg acttgaatta
    10681 cgagttgctt gagaaaaacc attttctaaa gctgggaagt ctgctggagt cacttcgact
    10741 ggatcacgtc cgtcgatgat ggcttctact tctgcagcca gttctggatg agcttcttta
    10801 taatctgcaa ctaatttagt ccaagcttga taagctgatg cgccacggtc tgcaacatgt
    10861 tctttgaaat cagcatatac ttgttctgga atttcaaatg gttcgtagtc ccaaccgagg
    10921 gcttgacgag ttgatgcagt ttcatctgct ccaagagggg cgccgtgtac agcattagtt
    10981 ccttgtttgt ttggagaacc gtatccaata accgtcttca cttcaatcaa agatggcttg
    11041 cctgaagctt ttgctgtttc gatagcagca tggatggctt ccaagtctgt tccattttca
    11101 accaaggcag tatgccaacc gtaggcattg taacggtcac gaacactttc tgtaaaggaa
    11161 tcctttgtct caccatccaa gttgatatca tttgaatcat aaagaacaac caacttatca
    11221 agtttttgca aacctgcgta tgaagctgcc tcgcttgaga caccttccat caagtctccg
    11281 tctccacaga taacgtaagt atagtggtca aagatattgt agccttcacg gttatatttg
    11341 gctgccaaga aacgttctgc ttgggcaaaa ccagtagcag ttgaaatccc ttgccctaga
    11401 ggacctgtcg tagcatcaat ccctgccgta tgaccaaatt ctgggtgacc tggtgttttt
    11461 gaaccccatt gacggaaact cttaatctca tccatgctga catcttcaaa accagaaagg
    11521 tgaagaagag cataaaggag cattgaacca tgacctgctg aaagaataaa gcggtcgcgg
    11581 ttaatccagt ttggttgagc tggattgata tgaagttgtt ttgtaaagag gctgtaagcc
    11641 atcggagccg ctcccataac cacacctgga tgacctgagt tggctttatt aatggcgtca
    11701 atacctagaa aacgaattgc attaacagat agatttgaca tagaatttcc tttctatttg
    11761 aggtgattat tgaatcacac attctatttt actattatat gaaaattatc cgtatcatgc
    11821 aacatacgga taacctccaa agaatatttt tatattatag caaagcttta aattgaatgt
    11881 tagagtcttg ttcaaaacaa tcatcaaaac cacgtggatg atggtattct actaagtgtt
    11941 gatcttgagg ataagtgtac ttaccgccaa cttcccagat aaatggatgg aaatcgtatt
    12001 gcaagcgatc ttttcgcatt ttccaaagtt ctagaatctc attagtagaa gccatgaagt
    12061 tagaccagat atcatagtga actgggataa tgactttggt acgcagattt tctgccatac
    12121 gaagaaggtc gatagatgtc attttgtctt ggatacctac cggattttca ccatagttat
    12181 tcaaagcaac atcaatttta aagtctttac catgttttgc aaaatagttt gagaagtgag
    12241 aatctgcacc atgatagatg gttccacctg gtgtttcaaa gatatagtta acagcctttt
    12301 gagccatttc ttcatctgta acagccaagc cagcaagttc accgcctgtc tcatcagcac
    12361 cgttcactgg gagagttacc aagcaagtac ggtcaaatga ttctactgca tgaatcttca
    12421 tatcttttaa ttcgatagtg tcacctggtt taacaacgat gatacgttct tttggaaccc
    12481 cccatccttc ccagattcgt ccacagtggt aaggaccgat aaacttaaca tgctctaact
    12541 taggattgtt gagaattgct gcagctgtgt atgggtcgat atgatcactg tggaagtgtg
    12601 aaactaagta atagtctagt tcgttgatag caaatggatc gataaccatt ggctgaacac
    12661 gcaagtttgg ttgcaattta cgaacacctg ccatatttgc catttggtgc ccacgaacca
    12721 tatctttcac ttttttggtt gattttccac ggtttgacca aaggtccatg acaacgttag
    12781 caccagctgg tgtcttaatc caagtaccac agttgcctag ccaccacatg gcaaagttgc
    12841 cttcaggtac gacttcttct tcgatttctt cgttcaacca tgttccccac tctgggaaag
    12901 tggctaaaat ccatgactct cttgtaattt ctttgacgtt tggcatatgt tgcctccttt
    12961 ggatataatt gttatctttg agattagtat accacccttc aaaacactaa aaaagaccaa
    13021 gaaaaacaca ggtttgtgtt catcattgga ctgtccttca aatatcttcc aaaaaagctt
    13081 gaactactat ttcttgattt ataagtgttt gaacctcttc ttagaactta ctagccaact
    13141 tgctgtctac aatataagac gaaataagac tagaaagatt ttcactgaaa cttttgctct
    13201 tattacgaaa tatattgtgt ttaagatagt ctagcatttt caaaatatct tctgcttcaa
    13261 ggataggatt aacccttaaa atcggaaatc tgctatccaa atcatcatta gtagtaatca
    13321 ctacatcaac ttgtgcaata tcttccacac tcttaaattg ttctgttgta aatacagtgt
    13381 caatttgctc atttggaaaa taaagtttgc attgtttcag caaaagtctc gaaaccgcaa
    13441 caccttcatc acaaacgaga taaacttttt tcatattttt ttgagacgat ggtgtatact
    13501 ttaaaaatcc tccaatatga atcgtcaaat aggcaatatc atcgtctgtt agccgaataa
    13561 accatgctcc ttctaaaatt tccgcagatt ttctagtgac taaaaataat tctccatact
    13621 tggatcgaat ttgttttgtt agaggatttt tagaaaaaat accgtaagtc tttctaaata
    13681 acaaggattt acagtggatc atcaaatttc gtaacaaatc atccttgttc tcaatctcca
    13741 ttcggatttg tgattcaaaa taccagataa attcttctaa agcaagtttt aattgccgaa
    13801 aatcatcact ttctgcatga atatccaaat ctttacgata ggagaggagg agaacagcta
    13861 caagagaaac ttcaagtcct gacaaagaaa tttcaaactt ttgaaacaac cgttctccta
    13921 atttcttaga cacctgatac tctattcttt ttcttatcaa agaaaattct ttctctatat
    13981 cctgatgtct ttcttgatac tgttcaacat tatgacagct taacagcaaa taaggtagaa
    14041 cctgcaacat aaaagttatt tcatgatggt ttattttctt ccctaaatct tgttcaacta
    14101 aaggaacctg ttccttaaaa aattggttca tttcaacaga aagcaaacac tcatcatcta
    14161 acctctcttt catcttatct tctaaaatag atacaaaagt ggcattttct tccataaaaa
    14221 tatgatatag aagcgattga agatactgaa ttttattaag agggtgggca tgaaggtggt
    14281 atccctgtga cttgctcact tgcaagatca cctgatattg ttccaaagtt agttgataac
    14341 gaatactatt caaatcattg agaacagtat tcctagatac ctctgttaac tctatcaatt
    14401 tttcaatcgt aatacgttct ttagaaatac ctatccatag taacattatc atcatacgtt
    14461 catgcgcact catgatataa tcgtacgaat ctacttccga taatagttta caacaagcat
    14521 ctctctgctc ttccgttaag tgaataccaa ttcgtggaat actaatgatg tgaagcgcct
    14581 cgtcacccag agcagcattg attttgtcaa tgtgataata aattttcctt cttgactctt
    14641 tcaaatcttt cgaaatcgcc ataatcgttt tggacgtttc ttgatccatc aaatattgaa
    14701 gcaaatcaca acttgcctta tccagtacca tattaaaaaa tcccccaaat ctattgatat
    14761 cacagcaatt ctttttattt taccatatat atatcaagcg ctatttctaa aaaatctttt
    14821 aaaattactt caattccaac tttactctca ataaaaatca aatgtaaaaa gaggagctaa
    14881 atttatcttt ttctcctcct tcatcgttct tacttttgac cataataagc atttggtcca
    14941 tgtttacgtt ggtagtgttt ttctagtatg tactggggag caggtccaac tcttggattg
    15001 atttgttctg taaagcgatt catctttgat acttcctcta gtacgacaga gtgataaaca
    15061 gcattctctg gatttttgcc ccaggtgaat ggaccgtgat tgcgtacaac aattcctggt
    15121 acttcaaccg ggttaagtcc gcgatgttca aactcttcta cgataaccag gccagtatct
    15181 ttttcatagg ccacttctac ttcgtccttg gtcaaactac gggcgcaagg gattgaaccg
    15241 tagaaataat ctgcatgggt tgttccgtag aaaggaatat cacgacctgc ctgagcccaa
    15301 gcaacagctt ctgtcgaatg ggtgtgaacc acactaccaa tttctgacca agccttatat
    15361 aattgcacat gagttgggag gtcggaagat ggtcttaaat ccccttctag gatcttacca
    15421 tctagatcag tcactaccat gttttcaggt gtcaattcgt cataatccac gcctgatggt
    15481 ttgataacaa tgacaccgag ttcgcgatta acttcagata cattccccca ggtaaatttg
    15541 acaagtccat gttttggcaa tgattgattg gcatcacaga ctcgtttacg catagcattg
    15601 attacttgat tcatcttaca tcaaacctgc tttcttaatg agtggataga gaaaagcttg
    15661 cgcctcttga acggctgcgc gtgtttcttc tactgtttca caattttcag accacatttc
    15721 gattaggaaa ggtccattat aattggtttc ctttaaaata tcgaaagctt cttcccattt
    15781 gacacaacct tgcccgaaag gtacatctcg gaactggccc tttgaacttt ctgtcactgc
    15841 ataagtatcc ttgagatgga gagctgcgat ggcatgatga ccaagataaa actcactata
    15901 gatatcatta tgccatgcag acacattacc aatatctgga tatacaaaga ggaagggaga
    15961 gtcaatctct ttttctatag ccaaatattt ttcgatgcta ttgatgaaag gatcatccat
    16021 aatttcaata gcaagtacca cctgagcttc ttcagcccag tcacaggctt ttctcaaatt
    16081 tttgataaaa cgttggcgtg tctggggtga cttttcctca tagtaaacat cgtaaccagc
    16141 taattgaatc gtacgaactc ccaagtcttg agctaattcg atacattttt tcatgagttc
    16201 tagagatttt tcctctagaa ctggatcttt tgaacccaat gggtagcgac gatggcctga
    16261 aaaacagata gaaggaatac gaacaccagt ttcatagatt gctttgacaa cttccaagcg
    16321 ttcttcctta ctccagtcaa gtcttgctaa acgctcgtca cgttcgtcaa tagacatctc
    16381 gacaaaatca aagcctaact ccttggcaaa atttaaacgt tctagccaag taaagtgtgt
    16441 tggggttgcc ttttcataaa ttccaattgg acgtaccatg atttaccccc aaattcgttt
    16501 gatttcatcc ttgaaggcac gcgctgctcc tgctggatcc gcagcctctg taattctacg
    16561 acctgcgata aaggtaaaga catcaacacc ttcaaagagt ttgagagtat ctacatctag
    16621 accacctgtt acagatacac ggaagcccat gtcaatgagt tttttaacct tattaaggtc
    16681 tttttcaccc caagtttcac cagcaagaag agcatcacga gattggtgat aaatagcttg
    16741 tgagatacct gcatctagcc aaagctgagc ttgttcaaaa gtccaatcgc cataaagctc
    16801 gatctggatt tcgcctcgtt ctcctcgttc agtcttgata gcctttagag ctgcttccat
    16861 agtagggatg gttgcacaac agatacaagt catccagtct gctccacgaa ccgcattatt
    16921 tttagcaact gttccaccag catcagcaca ttttgtgtct accacaataa tcttatctgg
    16981 gaaaaggcta cgcaagactt cagccagttc acttccaact tgaagcaagc aaacagttcc
    17041 agcttcgata atatctactt cctgaccaac agaaacagct gctttaatcg ctccttgcaa
    17101 gtctgaatgg tctaatgcaa cttgtaaatt aggtattctt tttgtcattt ctttattcct
    17161 ctttctaact ttccaaatcc aatccttcga gataagggct atccttagat tcttcaatca
    17221 tagccaagac atcttcttta gtctggcaag cctgtaaacg tgcaatagaa tcttctaatt
    17281 caaacagggc aataatttgt ggaatggcca cacttgtgtg aatttttgaa cttgttgctg
    17341 ctagtgccaa caaaacagat acctctttcc catctgaaaa tacaacagga ttttgtaagg
    17401 taatcaatga aaaggcatca ctttgcacac cagcttcagg tctagcgtgg ggcatagcca
    17461 tacctggcat caagatatag taaggcccat actcttcagt cgattcaatg atagcatcgt
    17521 aatactctgg caaaattgcc ccactttcaa tcaagggatc tactgctacc ttgactgctt
    17581 ctttccaatc gttagcctct aaacctagtc ggatcgagtc gttgtcaatt aaagcttgtt
    17641 ttaaattcat atctgcctcc tttatttaaa gagggagaag gacagaaacg ataactctca
    17701 gtttctgtcc agtcccctcc aaccttttac tatagtgctt gactgagttt ttcggtgatt
    17761 tctttatcat ccatcaagtt atcaagacca attaacttcc cattagttcg cccttccaat
    17821 tcttgaatca aatgaagaga agcgattacg atgtcatatc ctactgctaa acctttagct
    17881 tcaccgacac tgcatgaatt gactgtaaaa tctgtttgat taagcttacg gagagcattt
    17941 tcaaccttca tcttgataac cattgatgaa cccattccat ttccgcacgc tgctaatact
    18001 ttaaccattt tatttctcct tttctagata ctaagcttct tcttgaactt caccgttgta
    18061 atatttctct ttatcttttg ctttggcaaa ttgaagttga ggaataacaa gcaagaagag
    18121 acacacaagt acataaccaa caataccaag gtatttgaag atatatccaa atccaagcca
    18181 tgggaattca aagtcgatat ttccatggta gccaccataa gatgccaaat cgagaagggc
    18241 cacacaaaga gctcctagag caacttgaag gacacctgat ataaaggaaa ggataacagc
    18301 cgctttccat ccgccgcgtt tatcagcgta gaccgcaatg gctgcattgt caaagaacac
    18361 tggtacaaat cctgtaataa taagaatcgg atttttaaag acgatgagca agacaattgt
    18421 aatcaattga ccaatcaaac caaaggtaaa tcctgacaag acagcatttg gagaaccaaa
    18481 tccataagaa gctgcaacgt caaccgctgg gaatgaacct ggcaacaatt tgtttgaaat
    18541 accttggaaa gcgtttgtta actcagatac gaacattcgg acaccttgca tcaaaacgaa
    18601 caagtaaact gagaaggtaa aggctgtttg gataatgtac ataaagaaat cttgtttagc
    18661 aggattgaat agagttcctg aagtgatgac ttctttatta gacataatgt ctggacccaa
    18721 gattaaaaga atggccccga agaatacgag catcaaggta gcagatgcaa caactgtatc
    18781 gtggaagatt gagaggaact taggtaattt aagattgtct aaactttctt ctttcttacc
    18841 aaagcgtcct gctactttat ctacaaacca gattgcaaat tgctgttggt gaccaatcgc
    18901 aaatccgcca ccaccagtca agcgttgagt tgcctcaaca gtcatatttg aactaactgc
    18961 ccagtaaagt ccacagatga taccaatcgc tgctgtaccg taagcattgc gcaattgtgg
    19021 tactaagaat agaaccataa gagatactgt tgcagcttgt tgtaccatga tgtgaccagt
    19081 aataaagagg gttcttacct tcgtaatctt tcgaagagct acgagcaaga tatttattcc
    19141 gaaaccaatc aatagagctg tagttgcagt tccaacaaaa tctggaaact ctgctgcaat
    19201 tttgttgttt gctgcagcaa gtccaaagta agggtcgata accgctgcac caatttggaa
    19261 tttgtagtta agagctgcta agattggacg aaaggttgta accaaaccac cagcacccac
    19321 gttaagcaac atatacccta ctgttgcttt aacaaaccct gaaaaaacgt catgggcagg
    19381 ttttttcaaa agtgcatatc ctatcaacac caataaacct acgaaaaatg cgggattctg
    19441 caaaatattg ctagaaaacc aatttagaac acttgaaacg acttccataa ttgttctcct
    19501 tttgaattgt ttttgtaagt ttattatata atgcgaaagc gcaaacaaaa agaccaagaa
    19561 ttacacagcg gactgttcac tcttggactg tatgatttat gatgttttac aaattatctt
    19621 attttctcgt agctagataa tagggaagaa ttttagaata agacttcaat aagccttcta
    19681 cgatttcttc ttcagacgaa ttttctgtca taggaacatc taccttcact aaaacttttc
    19741 gaacttcttg acttctcacc ttctcgcgta aagtacgacg cttttcttca ttcgcctccc
    19801 accgttgact ttgaccatta gagtaggtta gataataaat ccctttaacg gttggaatgt
    19861 ctaaaatctt ggcctgcttg cccagtgttt gctcatcctt cttacgttcg atgaaactga
    19921 cttccaaaga aattccaaag tcagtagatg tcccatacaa acgtaaggcc atcataggtt
    19981 ctgtcacttg tccgtctctc tgtagataaa cccaaaaatg tggtctcaaa cgctgggcct
    20041 gattcatcca ctgactagtc tgttggagtt gccattctgg atggcttgct tgaaaggctt
    20101 tggccagttc tgtaaaagcc tttcgggcct cttgtccttt gtggcggaac gccagcatct
    20161 tctctcgctc tgctcccgct ttatcaggac tacggtactg caaaccagaa aagtctagat
    20221 agtctcttat cttattcaac atcagtttaa cctcctctag ctagcaaaaa atcaggtcaa
    20281 ccctgatttt acttattctg tatctacaac gacatagcga tttggctcat caccttcaga
    20341 gtaactggtc acgccatcca tacgtgaaat aatacggtgg ataatcttgc gttcactatt
    20401 cgacattgga tctgtttgat gactacgtcc ttcttctaaa acacgaatcg ccaatttttg
    20461 cgcataggtc tgcaagactt ctgcacggtg ttcaacataa tcattgacat taatagtgat
    20521 atagaaggtt cttgaatagc agttgtaaag ataattttga gccaacagtt gcaaggcctt
    20581 caagacttta ccatggtagc cgataatacg acctggttcg ttagtatcaa tttgcaaatt
    20641 gatgctacga cggttataat catttgaaag tgtagcctca acatccatgt catcaataat
    20701 cgtttgaaca taagcagtca catccgtagc cacctgggca atatcataac tttgctcgac
    20761 cttcaagccc atctctttca agtcttgatt ttcagtttga tcttgctcag tttcaaggtc
    20821 atcagcgcct gcttcttccc tcatcgcttc ctcgatttga agttcattta aaatctcaat
    20881 gtgaccagtt tcttctaaga tagtgctggc atgtctttca tgttttaaga tttcagcctt
    20941 gacttcatca gaaatacctt gaccttcttc ctctattttt ttaatagcat caaccacatg
    21001 accaaggtca acggtttctt cactaacagt cttcacaggc tcgttcaaat cattgatttt
    21061 tttcggaacg ccttttacta cctgttgatt tgctttgaca acagtcgttt cactaatcgc
    21121 ttcaatatcc acttgggctg gttttttacc aaatagacca agaaagcctt ttttctccct
    21181 agaaatgact ttgatatgag ccttcattct tggaatatct aattctttca atcctttctg
    21241 gattgcttct tcaacagttg aacctgtaaa tactaccatt accagattcc tccttattta
    21301 tttcgttttc tgagcctttt tcttggcttt tctttttcta ttttccaaat ctttttgtgc
    21361 ctgtactacg gcctcgcgct ctgcgataat cttgaatgga ttattcaaga aataggtttg
    21421 caagacttga taagcattag acactgtcca gtatagggcg actccacctg gcgcataaac
    21481 tgcaaagata aaaatcaaga ctggaatccc atacatcatc gcagtcgtag cgccatttcg
    21541 ctcagacaaa gctttgttgg acaaccaagt acttaaaaag gtgaatactg ctgctaaaat
    21601 cggaagaaca agggttgtat ccacactacc aaggttaatc cataagaaat gacctgtctt
    21661 taaaaagtca actcttgata gggcttggaa cagggccaaa ataaccggca tctgaatcaa
    21721 aatcggccaa agagagtctg actgtctgac acccatttct ttaaatactt tacgcatttc
    21781 ctgctctagt ttggttctgc tttccatatc tcgacctgga tattgttctc gaagcgcctt
    21841 aatgcgtggc tgagcttcct gcattttcct agaagccacc atttgcacct gaaagactgg
    21901 caagaggact gtacgaatca agaccgtaaa gagaataatc cccactccga tactaatatc
    21961 aaacgataaa aagcgaatga tttccgcaaa gaagtaaacc aatttactcc aaaaatcagc
    22021 cgattcggct gtaatatcgc tagttacccc attagtcgca caggctgtca tgattaacag
    22081 agacagtcct agcaaactag tcaactttag tttctttttc actcccattt ccttcccggt
    22141 aaatctttga taattttaat acatggagta gatttttctc catctctgcg tatcccaagg
    22201 tttcgactcc ttttcgagca atgacaacaa agtcgacatc ttctaccaga ctcccttttg
    22261 cattctggat aatatgccga atccgtcgct taatttgatt tctagtgacg gcattcccca
    22321 gttttttgct aactgataga cctactcgaa aatggttttt ctggttttct aattggtaga
    22381 ccacaaattt gcgattagca aaacttgtcc cctccttgaa aatcgcctta aaatctttct
    22441 ctctttttac acgaaagttt ttcttcaaaa ctcaactcca tctattaaat tactactatt
    22501 ataccatatt tttcaaaaaa gccaatcata gcaaggtttt ggacaatttc atcagaaaaa
    22561 gaagctggaa aaataacttt cccaactcct tgtattgaat atttttttag tttcacttat
    22621 tttttcaagc gttcaacgtc acgggcaatg actaattctt catctgttgg aataaccaag
    22681 acacggattt tagctgcctc tgttgagatg tctcctgtaa cgccaaagac attcttttca
    22741 tcatcaacat cacaaccaaa ccacgaaatc cctgagatta catcacgacg gaaattctct
    22801 gcattttcac cgacacctgc tgtgaaaaca atggcatctg ctccatttag cactgcaagg
    22861 tactgaccga tatgtttttg gatacggtca acatacattt cataagccaa gctagcctcg
    22921 tgattccctt ctgctacagc tgcttctata tcgcgcatat cgctagaatt agcagaaact
    22981 cccaaaagac ctgattcacg gttaagaaca cgactgatat cttctggtgt gttaaaatcc
    23041 tctgtatatt gcattaaata aggaatgata gctggatcaa tatcccctgt acgcgttccc
    23101 atcataatac caccaagagg agtgaacccc atagaagtgt ctacagattt gccggctttc
    23161 acagctgtaa ttgagcctcc gttaccaata tgacaggtaa ttaacttcaa gtcttctaat
    23221 ggacgtccca agagttttgc agcttctcct gctacaaact ggtgacttgt accatgagca
    23281 ccgtatttac gaaccttgtt ttctgtgtaa tattttgttg gtagagggta gcgataagct
    23341 ttctctggca tacttgtgtg gaaggaagta tcaaaaacaa ctacactggt aatgtctggc
    23401 aacaattcct tgaaggcacg aacacctgct gcattggccg ggttgtgtag aggagccaac
    23461 aaactcaact cttcaacttt ttctaaaaca tctccctcaa caactgttga ttctttgaaa
    23521 tattctccac cagcaacaac acgatgtcca acacctgtaa tctcgtcata agccttgata
    23581 atatcgaaac gaatcaagtc atccaataaa attttaacgg cttgtgtatg attttcaata
    23641 tccaaaattt gttgttcaga acggccgtca aattttacag ttgaaattga atctttcaaa
    23701 ccgatacgtt caatcaaacc tttcgccaat actttttctt ctggcattaa gtataattgc
    23761 catttcaaac ttgaacttcc tgcattgatt gcaattgttt ttgtcataac atgatacccc
    23821 tttttaagcg ttttcaacta ttataacaaa atctatttta tatttcagta ccttgagtcc
    23881 atttttgaaa attttcttta aatttcatta aaacacttgc atcttgcaag ctagcaagtg
    23941 gataaacaaa aggctctact gctatttcat ttttcttctg taggataaaa atagtcttag
    24001 attgtttagc attagcaaag agattttcag gcagactaat catagcaacc agactcgcct
    24061 cttctttcag ccattctttt aacaaatcac tttgaggact ggtcaacaaa tcactcggag
    24121 ctagaaaaat agcgtatccg tctgacttga ggtacttaag cccttgttcc atgagcaagt
    24181 gatgggcgta agtatgttct tggctagaag caacttgatg gcgcgacgca acggcatcat
    24241 caggataata gccaacaggc aagtcactga tgaccacatc gctttctttg agcatttgtg
    24301 gacgaacggc atctccttgg acaaagccag cctgcaaacc aattacatct gccatgctag
    24361 ctgccagatc aatcagtaaa tcatccactt ccattcccaa gtaatccacc tttttatcaa
    24421 gcgaggtcaa gaaagtagcg cctagaattc ccatcccaga acccatttcg aggatagtaa
    24481 tttcctcctc tttaaacaac tcttccacaa taaacaccaa aagcaaagca atagcatccg
    24541 gtgtaaactg gtgattggcc tgcaagggtt ctgtttgccc agccttcatc aagagaaact
    24601 ggtaggtctt gagccattct tctttgcgta gtgctaaacg cttaagggcc tgattgttgt
    24661 ctttgacctg gtttagctca gtttcaccat ccagatagat gctgttttgc tccaccaagg
    24721 cgtcataaaa gttggtcgcc aaatcacttt ggatgacttg gacattctct agtaaatagg
    24781 tataagcttg ttcaattttt tcaaaatcca tattcctatc ttatcaaatt tcccttcttt
    24841 tttccatcct tatagaaaaa tcactccctg actaggcgag tgatttttgg gctactatta
    24901 aaaagaattc tgagtgattt ccttgaaaca ggtcttcagc gctatagaga atctgactat
    24961 gcacagatga aaaaccatgc tcaattagct tgttttccag ttcagctaaa tcaaatccat
    25021 gatgattagc ttctgtcttg gtaaaatcag caatgatgag tttcccatct tccttcaaat
    25081 gttgatgaaa cagtgagaga gccgcatcca aatcaggcat atgatgaaga acccgactaa
    25141 cagcaaggca atcaaactct ttctccaagg gatttttcgg taaatcttgc tccaaaaact
    25201 ggatattctt gattgcttgc tgctccactt tcaaacgagc ttgctccaac attttctcag
    25261 aaatgtctac aagagtgact gacttagcct gcttggctag gggttagggg caaggctaat
    25321 agacccgcca ccaccgaaat ctaaaatttc tttgtctgat agaagatcaa tctgtttctc
    25381 ggctgcttga cataccaagt ttgcgaggaa gatattttta ggggaatcga aagtttctgc
    25441 tttgtggtta aaatcatgtt tcatatcttt agtttagcac aaagtatagt aaactgaaat
    25501 aagatataaa caaatgaatt ggagattaac atccatttcc agcaattttc tagaaactac
    25561 agtggactat tctggattca acgcattata gttgaattga ctatgaattc tctttctttt
    25621 caggcttctc ttctgatttt ttttctccgc tttttcgctt gaatcagtca ctacctcttc
    25681 ctttttatcc gttttctctt ctttgatttt gactgaagaa aacagaaact catattgact
    25741 cttatccgta cgaaccctcg tcactaagcc agttttcttg ttttgatagc ttacctgacc
    25801 tagattaaaa acctgttccc cactttcttg ctcaacctta tctttggttc gtttagccat
    25861 agcaaaagca accaattttt ctttattcaa agcatagtct tgatagtggg cgacttgtcg
    25921 gttcaagtaa aattgcaaca aaagactaaa gatagctgcc atggtgactg catagaggag
    25981 aacacctgcc ttaactttct tctttttcca cacgatagat gaactccctt tctaagcctt
    26041 tttgaaactg gaaacgaaaa tgaaccagtt gattgtcctc tgtaatctga gctgatttga
    26101 ggccataaac cataggctga tacccccgtc cactagcatc ggttttacga aaatcgtctg
    26161 actttgactt accgatggcg atgtccttgc catcttgctt catgtatagg cgattgcctt
    26221 ctactttttc gaactgcgaa cggtctaatt ctacctcaag ttggtccaca aacaagagcc
    26281 actccttttg ctcgctttgt tgctggtagc gaacttctga aatgaggagc tgactcatag
    26341 cttgaaaaag gagtaatccc ccactgatga caatgagggc aagcagggat tctaacaagg
    26401 taaaagcctt gaccttatgg ctctttgatt gccaacaact gttctgaacc atggtagacc
    26461 tccaatcctt tttcactaga aaatacctga atctcaactc cgttgatgct tacctgattt
    26521 tgccccgtct gcaaggccat cttagctacc ctcaagactt cttccttttg caagattttt
    26581 gcttcctctt gcctattttt ttgaatttgt cccaaaagga gggtcgcaat gctggcaaag
    26641 atagctagag cgactactgc ttccagtaaa atcactgccc taattttttg tttccttaat
    26701 gcgtttaatt tttccatttc ctagatataa ttgatagcga atcgctcctt tactggtctg
    26761 aaattcaacc ttagccaggg acgaattgcc cccagcacgg tcaaatgtaa tactttggcc
    26821 tgatggggcc tgaattcctt tagggactgg caacttttga ctgccattgc taatcatctg
    26881 cccatccaag ttcagactag tcttttgttg actagctaca ctgcgttttt gggtttcccg
    26941 atagagttct tcaaactcca taaagaaaat ctgttcctct accgctgcaa aagtggactg
    27001 gacagagccg gacaagccca aggcaaggat actcacaagt cccaaaacca agagactttc
    27061 cagcatggta aaggccttaa tctttaacga tttgactagt attttgttta tcatggtatt
    27121 ctttataggc tttagcctgt tcttccgtga tgcgtccatc gtcttgtaac tttcttaggc
    27181 tagcatcttc attcttttcc aagctataaa gttctgcctg gctttccacc accttaacaa
    27241 cagctgcttt tcctttgtca ttgactgctt ctttttgctt ggtcagatta ggtacaaaga
    27301 gcaagaaaag cacgctgata atcagcaaga ccaccaacat ttcaatcaag gatagtaaaa
    27361 ctctcactct tttctatctc atacatcttt accgaatgca acacgagatc acgatacttc
    27421 caagtgctga ccagatactc aataacctct tggtcctcta tcctgcattc cataagtaat
    27481 aatagtttga ccgtgtattc attcttcaaa atcggaacct gataagtcac atctacccaa
    27541 tgctcaaaac ctaagtctgt ctgctctaca tttgctagtt caatatttaa aatcttcatt
    27601 tttattcctc ctacttatct attcgtaaaa gaagataaaa agttatgaaa aaatcattac
    27661 ttttttaatt cagacagtac tttcagagca attttgttaa tgtcaacaaa attggcaacc
    27721 aagcgattta atactatttg ttgacgccaa caagtcaatt ttcagacaaa caaaaaaacc
    27781 gcaagcctga gcctgcggtg aaagaacaat ttagaaagtt tcctttctat ttatttaact
    27841 gcaatcaagc catctggctc tactgtgaag tctggcttat ctaccagtgt tccgtctggt
    27901 ttgaggtagt accagcctgt tccgtctgcg gactggacga aggcgtttga taccatggcg
    27961 ccttctttag cgtctaagta gtaccaggtg tccttgtact tgacccagcc tgtcttcatg
    28021 gcaccttcta catcaaaata gtaccacttc tcagcgattt tcttccagcc tgtagccatt
    28081 tcgcctgagt tgtcgaacca gtaccaatt
//
LOCUS       DAVLHC010000027        26076 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.027, whole genome shotgun sequence.
ACCESSION   DAVLHC010000027 DAVLHC010000000
VERSION     DAVLHC010000027.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 26076)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 26076)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..26076
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.027"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..1229
                     /locus_tag="VXE25_001302"
     CDS             <1..1229
                     /locus_tag="VXE25_001302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000688702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="glycoside hydrolase family 31 protein"
                     /protein_id="HEV0771761.1"
                     /translation="FFCLTFGVSTLWLLNHYHYQDSCKNAEGGLILSRYAGPGSHRYP
                     VGFSGDTIISWNSLRFQPYFTATASNIGYSWWSHDIGGHMLGDYDEELQTRWLQFGVF
                     SPITRLHSSRSPFNSKEPWFFSETTSKIMKKYLRLRHQMIPYLYTMNVKTHEEGAPLI
                     SPIYYFYPENNESYNVPNQYFFGTELMVAPIVEKMDLTFQSAKVDVWFPEGEWYDFFS
                     EKKYTGGVKLSVYRDISTTPVFAKSGAIIPLVGSEIGMGVDLPEVVDWYVFPGKQHSF
                     EMLEDQNGQRYKTRLSIDWEMGMVELALQGDSSIVPSNRKHRIHFKGTNVSIIELPNK
                     NDTAKFEWKDNKRTSLNDEVFRLLKTASLPYELKDRLLNQFINAKNSHDLMNILHHQD
                     KELRGSLLEMIFTSQN"
     gene            complement(1451..1927)
                     /locus_tag="VXE25_001303"
     CDS             complement(1451..1927)
                     /locus_tag="VXE25_001303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutathione peroxidase"
                     /protein_id="HEV0771762.1"
                     /translation="MTSLYDFSVLNQNNQATPLDSYRGKVLLIVNTATGCGLTPQYQG
                     LQELYERYQDQGFEILDFPCNQFMGQAPGSAEEINAFCSLHFQTTFPRFAKIKVNGKE
                     ADPLYVWLKDQKSGPLGKRIEWNFSKFLIGRDGQVFERFSSKTDPKQIEEAIQTLL"
     gene            2150..5353
                     /locus_tag="VXE25_001304"
                     /pseudo
     CDS             2150..5353
                     /locus_tag="VXE25_001304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001193686.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG-anchored hyaluronate lyase"
     gene            5701..6077
                     /gene="tnpA"
                     /locus_tag="VXE25_001305"
                     /pseudo
     CDS             5701..6077
                     /gene="tnpA"
                     /locus_tag="VXE25_001305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011148688.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS200/IS605 family transposase"
     gene            complement(6465..7094)
                     /locus_tag="VXE25_001306"
     CDS             complement(6465..7094)
                     /locus_tag="VXE25_001306"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000167291.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional 4-hydroxy-2-oxoglutarate
                     aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase"
                     /protein_id="HEV0771763.1"
                     /translation="MTKSDTIIELKKQKIVAVIRGNTKEEGLQASIACIKGGIKAIEI
                     AYTNQYAGQIIKELVDLYQDDQSVCIGAGTVLDAVTARDAILAGANYVVSPSFHAETA
                     KMCNLYSTPYIPGCITLTEITTALEAGSEIIKLFPGSTLSPAYISAVKAPIPQVSVMV
                     TGGVGLNNIPQWFAAGADAVGIGGELNKLASQGNFDRISEIAQQYITLR"
     gene            complement(7104..8105)
                     /locus_tag="VXE25_001307"
     CDS             complement(7104..8105)
                     /locus_tag="VXE25_001307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar kinase"
                     /protein_id="HEV0771764.1"
                     /translation="MTKILLFGEPLIRISPLDATSIGDHVASSTYFGGSEINIACNLQ
                     ALGISTKVFTALPANEIGDRFLTFLKQHQIDTSSICRLGDRIGLYYLENGFGCRQSEV
                     FYDRKHTSISQIRPNMLDMDSLFQGISHFHFSGITVAIGQEVRAILLLLLEEAKRRGI
                     VVSMDLNLRTKMISVLEAKYEFSKFARFTDYCFGIDPLMIDDQNLEMFPRDSASLEEV
                     ENRMRLLKEAYGFKAIFHTLRSSDEQDKNVYQAYALEERFEESVQLKTAVYQRIGSGD
                     AFISGALYQLLHHSSLKTTIDFAVASATLKCTLPGDHLSTSATSIENLLANAQDIIR"
     gene            complement(8136..8777)
                     /locus_tag="VXE25_001308"
     CDS             complement(8136..8777)
                     /locus_tag="VXE25_001308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RpiB/LacA/LacB family sugar-phosphate isomerase"
                     /protein_id="HEV0771765.1"
                     /translation="MKIALINENSQASKNHIIYDSLKEATDKKDYQLFNYGMRGEEGE
                     SQLTYVQNGLMAAILLNTKAVDFVVTGCGTGVGAMLALNSFPGVVCGLAVDPTDAYLY
                     SQINGGNALSIPYAKGFGWGAELTLKLMFDRLFAEEMGGGYPRERVIPEQRNARILNE
                     VKQITHNDLMTILKTIDQDFLKDTISGKYFQEYFFENCQDDEVAAYLKEVLAK"
     gene            complement(8796..9611)
                     /locus_tag="VXE25_001309"
     CDS             complement(8796..9611)
                     /locus_tag="VXE25_001309"
                     /EC_number="1.1.1.69"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000185867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gluconate 5-dehydrogenase"
                     /protein_id="HEV0771766.1"
                     /translation="MTNTSFSIEQFSLKGKIALITGASYGIGFAIAKSYAEAGATIVF
                     NDINQDLVNKGIEAYREVGIEAHGYVCDVTDEDGIQAMVKQIEQEVGVIDILVNNAGI
                     IRRVPMCEMSAADFRKVIDIDLNAPFIVSKAVIPSMIKKGHGKIINICSMMSELGRET
                     VSAYAAAKGGLKMLTRNIASEYGGANIQCNGIGPGYIATPQTAPLRELQEDGSRHPFD
                     QFIIAKTPAARWGNPEDLMGPAVFLASDASNFVNGHILYVDGGILAYIGKQPE"
     gene            9883..10311
                     /locus_tag="VXE25_001310"
     CDS             9883..10311
                     /locus_tag="VXE25_001310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000706826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEV0771767.1"
                     /translation="MKIVLVGHGHFATGIYSSLQLIAGNQENVEAIDFVEGMSADELK
                     QKILLAISNEEEVLILSDLLGGSPFKVSSTIMGENPVKTMNVLSGLNLAMLMEAVFAR
                     MAHSFDEVVNKSVVAAQGGVVNGKELFSTDAEEEDFELGI"
     gene            10323..11513
                     /locus_tag="VXE25_001311"
     CDS             10323..11513
                     /locus_tag="VXE25_001311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003074342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="unsaturated chondroitin disaccharide hydrolase"
                     /protein_id="HEV0771768.1"
                     /translation="MIKKVTIEKIKSPERFLEVPLLTKEEVGQAIDKVIRQLELNLDY
                     FKEDFPTPATFDNVYPIMDNTEWTNGFWTGELWLAYEYSQQDAFKNIAHKNVLSFLDR
                     VNKRVELDHHDLGFLYTPSCMAEYKINGDGEAREATLKAADKLIERYQEKGGFIQAWG
                     DLGKKEHYRLIIDCLLNIQLLFFAYQETGDQKYYDIAESHFYASANNVIRDDASSFHT
                     FYFDPETGQPFKGVTRQGYSDDSCWARGQSWGVYGIPLTYRHLKDESCFDLFKGVTNY
                     FLNRLPKDHVSYWDLIFNDGSDQSRDSSATAIAVCGIHEMLKHLPEVDADKDIYKHAM
                     HAMLRSLIEHYANDQFTPGGTSLLHGVYSWHSGKGVDEGNIWGDYYYLEALIRFYKDW
                     NLYW"
     gene            11524..12015
                     /locus_tag="VXE25_001312"
     CDS             11524..12015
                     /locus_tag="VXE25_001312"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000178618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system
                     mannose/fructose/N-acetylgalactosamine-transporter subunit
                     IIB"
                     /protein_id="HEV0771769.1"
                     /translation="MTMPNIIMTRIDERLIHGQGQLWVKYLGCNTVIVANDEVSTDKM
                     QQTLMKTVVPDSVAMRFFPLQKVIDIIHKANPAQTIFIVVKNVKDALTLVEGGVPIKE
                     INIGNIHNATGKEQVTRSIFLGEEDKVALKELSQTHQVTFNTKTTPTGNDGAVQVNIM
                     DYI"
     gene            12030..12809
                     /locus_tag="VXE25_001313"
     CDS             12030..12809
                     /locus_tag="VXE25_001313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000026606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS
                     mannose/fructose/sorbose/N-acetylgalactosamine transporter
                     subunit IIC"
                     /protein_id="HEV0771770.1"
                     /translation="MSINVFQAILIGLWTAFCFSGMLLGIYTNRCIVLSFGVGIILGD
                     LPTALAMGAIGELAYMGFGVGAGGTVPPNPIGPGIFGTLMAITSAGKVSPEAALALST
                     PIAVAIQFLQTFAYTVRAGAPETAMKHLKNHNLKKFKFTLNATIWLFAFIGFTLGCLG
                     ALSMDTLLKLVDYIPPVLLTGLTVAGKMLPAIGFAMILSVMAKKELIPFVLLGYVCAA
                     YLNIPTIGIAIVGTIFALIEFYNKPKTADHVVEEEAHDDWI"
     gene            12796..13614
                     /locus_tag="VXE25_001314"
     CDS             12796..13614
                     /locus_tag="VXE25_001314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000148012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose/fructose/sorbose transporter family
                     subunit IID"
                     /protein_id="HEV0771771.1"
                     /translation="MTGSNKLTKRDYLKTSLRAFFCQNGFNYSNYQGLGYANVMYPAL
                     KKHYGEDQEVFYQALEENCEFYNTNPHFLPFITSLHLVMLENGRPAKETRSIKMALMG
                     PLAGIGDSLSQFCLAPLFSTIAASFAQEGLVAGPILFFLAMNTILTAIKLSTGLYGYK
                     LGTTVIDKLSEQMATISRIANIIGVTVIAGLAATSVKIMVPITFAAGEVKADAKQSIV
                     SIQGMLDKVAPALLPALFTLLVYYLIKEKKWTTYKLVILTVIIGIIGSWLKIIA"
     gene            13614..13907
                     /locus_tag="VXE25_001315"
     CDS             13614..13907
                     /locus_tag="VXE25_001315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000381741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit YajC"
                     /protein_id="HEV0771772.1"
                     /translation="MDTTLFYGIVIVLAVSPLLLSSFHSIRQQKLLRKQMEQRQEYLA
                     SLTSGDEVLLLSGIHGKIISIKDDLVSLQIAKGVVIYVEKESVMGKTKELLFK"
     gene            13929..15830
                     /locus_tag="VXE25_001316"
     CDS             13929..15830
                     /locus_tag="VXE25_001316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000657070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alginate lyase family protein"
                     /protein_id="HEV0771773.1"
                     /translation="MKEERRQFFERVDGNQCRDYILSHCSKDYEKVKSSLERLMDNRF
                     MFDSPWDMEPCSKIHQIQPMVWDQVFEDDPEWSYMLNRQEYLLQFMIGYLVEGDKDYI
                     QKCKFFLFDWIEQVREFSPQSLMTRTLDTGIRSFTWLKLLLLLLKFDLLEEKELEKIL
                     VSLEKQIDFMKSYYRAKYTLSNWGILQTIPMLAIYHFFSDKMDLEEAYHFASEELKQQ
                     IETQILGDGSQFEQSILYHVEVYKALLDLCLLLPDLQDSYQELLEKMATYIQMMTGLD
                     GRTLAFGDSDSTETTEILSLSAVVLNKEDLLNGLDVKVDLLSLLFLGREKVKRLQEFE
                     RRAWQPKSMIFEDSGHVCIKDEHRYLFFKNGPLGSAHSHSDENSFCLQYQGQPIFIDA
                     GRYSYREIYERYLLKSAWSHSTCIVDGKAPERITGSWEYEYYPHSLFCHHKEREGMHY
                     IEGAYWSAEPDLPYLHRRKILMLVEDVWLLVDDIRCQGQHEALTQFILDKDVTYQDGK
                     INQLRLWSEVDFDLEDTIISPKYNELERSSKLTKRQFFENQMLDYTIIAHESFEIIRH
                     SVYQTDDREVENALAFEVKNDETDKLILLLSEDIGVGEKLCLVDGTKMRGKCLVYDKI
                     NERMIRLQC"
     gene            15890..16891
                     /locus_tag="VXE25_001317"
     CDS             15890..16891
                     /locus_tag="VXE25_001317"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000412458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEV0771774.1"
                     /translation="MEKKLTIKDIAEMAQTSKTTVSFYLNGKYEKMSQETREKIEKVI
                     HETNYKPSIVARSLNSKRTKLIGVLIGDITNSFSNQIVKGIEDIASQNGYQVMIGNSN
                     YSQESEDRYIESMLLLGVDGFIIQPTSNFRKYSRIIDEKKKKMVFFDSQLYEHRTSWV
                     KTNNYDAVYDMTQSCIEKGYEHFLLITADTSRLSTRIERASGFVDALTDANMRHASLT
                     IEDKHTNLEQIKEFLQKEIDPDEKTLVFIPNCWALPLVFTVIKELNYNLPQVGLIGFD
                     NTEWTCFSSPSVSTLVQPSFEEGQQATKILIDQIEGRNQEERQQVLDCSVNWKESTF"
     gene            complement(17001..17336)
                     /locus_tag="VXE25_001318"
     CDS             complement(17001..17336)
                     /locus_tag="VXE25_001318"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000838135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771775.1"
                     /translation="MKSLARLLIIHVFISIFLFFALISGAVSHTVLLLLLLFLPALNK
                     GLEKIQSKRIPVLNAALFFLLISFPQLLTNPVQWKFSIFLVVTIISSLAYFYNFYQVV
                     KEVDQKQLI"
     gene            complement(17347..17589)
                     /locus_tag="VXE25_001319"
     CDS             complement(17347..17589)
                     /locus_tag="VXE25_001319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000711734.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771776.1"
                     /translation="MKKEKRQLRYPGLKAGSIYGTVIFFIIPLIDTLTSENPNFISSL
                     LNTKHIFKTILGAFFFGVMIHIVDSLRIARAKKDQD"
     gene            complement(17600..18142)
                     /locus_tag="VXE25_001320"
     CDS             complement(17600..18142)
                     /locus_tag="VXE25_001320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000712356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3278 domain-containing protein"
                     /protein_id="HEV0771777.1"
                     /translation="MKKETFTEKLIKRTYGISGPLDEYKRREADRIGNQVFIILFYLM
                     IFGNLIPLLLAYKYPQEVALIYPPLILVIALIAAGYVTYQMKKTGITAIDPDMLSEKE
                     SKQLHYPGLKAGLFFGLWMFFITPLLRILIGEGQDYFHSLLTIRNGVSSILGSIFFGA
                     SIQFLISRRIAKTKKNQDED"
     gene            complement(18158..18352)
                     /locus_tag="VXE25_001321"
     CDS             complement(18158..18352)
                     /locus_tag="VXE25_001321"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001082472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEV0771778.1"
                     /translation="MNRVKEFRKELGISQLELAKDIGVSRQTINMIENDKYNPTLELC
                     LNLARSLQTDLNSLFWEDDF"
     gene            18518..19468
                     /gene="rsmH"
                     /locus_tag="VXE25_001322"
     CDS             18518..19468
                     /gene="rsmH"
                     /locus_tag="VXE25_001322"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466808.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (cytosine(1402)-N(4))-methyltransferase
                     RsmH"
                     /protein_id="HEV0771779.1"
                     /translation="MTKEFHHVTVLLHETIDMLDVKPDGIYVDATLGGAGHSEYLLSK
                     LSEKGHLYAFDQDQNAIDNAQKRLAPYIEKGMVTFIKDNFRHLQARLREAGVQEIDGI
                     CYDLGVSSPQLDQRERGFSYKKDAPLDMRMNQDASLTAYEVVNNYDYHDLVRIFFKYG
                     EDKFSKQIARKIEQAREVKPIETTTELAEIIKLVKPAKELKKKGHPAKQIFQAIRIEV
                     NDELGAADESIQQAMDMLALDGRISVITFHSLEDRLTKQLFKEASTVEVPKGLPFIPD
                     DLKPKMELVSRKPILPSAEELEANNRSHSAKLRVARKIHK"
     gene            19480..19797
                     /gene="ftsL"
                     /locus_tag="VXE25_001323"
     CDS             19480..19797
                     /gene="ftsL"
                     /locus_tag="VXE25_001323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000840841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsL"
                     /protein_id="HEV0771780.1"
                     /translation="MAEKMEKTGQILQMQLKRFSRVEKAFYFSIAVTTLIVAISIIFM
                     QTKLLQVQNDLTKINAQIEEKKTELDDAKQEVNELLRAERLKEIANSHDLQLNNENIR
                     IAE"
     gene            19801..22053
                     /gene="pbpX"
                     /locus_tag="VXE25_001324"
     CDS             19801..22053
                     /gene="pbpX"
                     /locus_tag="VXE25_001324"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000872287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein 2X"
                     /protein_id="HEV0771781.1"
                     /translation="MKWTKRVIRYATKNRKSPAENRRRVGKSLSLLSVFVFAIFLVNF
                     AVIIGTGTRFGTDLAKEAKKVHQTTRTVPAKRGTIYDRNGVPIAEDATSYNVYAVIDE
                     NYKSATGKILYVEKTQFNKVAEVFHKYLDMEESYVREQLSQPNLKQVSFGAKGNGITY
                     ANMMSIKKELEAAEVKGIDFTTSPNRSYPNGQFASSFIGLAQLHENEDGSKSLLGTSG
                     MESSLNSILAGTDGIITYEKDRLGNIVPGTEQVSQRTMDGKDVYTTISSPLQSFMETQ
                     MDAFQEKVKGKYMTATLVSAKTGEILATTQRPTFDADTKEGITEDFVWRDILYQSNYE
                     PGSTMKVMMLAAAIDNNTFPGGEVFNSSELKIADATIRDWDVNEGLTGGRMMTFSQGF
                     AHSSNVGMTLLEQKMGDATWLDYLNRFKFGVPTRFGLTDEYAGQLPADNIVNIAQSSF
                     GQGISVTQTQMIRAFTAIANDGVMLEPKFISAIYDPNDQTARKSQKEIVGNPVSKDAA
                     SLTRTNMVLVGTDPVYGTMYNHSTGKPTVTVPGQNVALKSGTAQIADEKNGGYLVGVT
                     DYIFSAVSMSPAENPDFILYVTVQQPEHYSGIQLGEFANPILERASAMKDSLNLQTTA
                     KALEQVSQQSPYPMPSVKDISPGDLAEELRRNLVQPIVVGTGTKIKNSSAEEGKNLAP
                     NQQVLILSDKAEEVPDMYGWTKETAETLAKWLNIELEFQGSGSTVQKQDVRANTAIKD
                     IKKITLTLGD"
     gene            22055..23035
                     /locus_tag="VXE25_001325"
     CDS             22055..23035
                     /locus_tag="VXE25_001325"
                     /EC_number="2.7.8.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000470804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-N-acetylmuramoyl-pentapeptide-
                     transferase"
                     /protein_id="HEV0771782.1"
                     /translation="MFISISAGIVTFLLTLVGIPAFIQFYRKAQITGQQMHEDVKQHQ
                     AKAGTPTMGGLVFLITSVLVAFFFALFSSQFSNNMGMILFILVLYGLVGFLDDFLKVF
                     RKINEGLNPKQKLALQLLGGVIFYLFYERGGDMLSVFGYQVHLGIFYIVFALFWLVGF
                     SNAVNLTDGVDGLASISVVISLSAYGVIAYVQGQMDILLVILAMIGGLLSFFIFNHKP
                     AKVFMGDVGSLALGGMLAAISMALHQEWTLLIIGIVYVFETTSVMMQVSYFKLTGGKR
                     IFRMTPVHHHFELGGLSGKGNPWSEWKVDFFFWGVGLLASLLTLAILYLM"
     gene            23644..23829
                     /locus_tag="VXE25_001326"
     CDS             23644..23829
                     /locus_tag="VXE25_001326"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="Clp protease"
                     /protein_id="HEV0771783.1"
                     /translation="MNNNFNNFNNMDDLFNQLMGGMRGYSSENRRYLINGREVTPEEF
                     AHYRATGQLPGNAETDV"
     gene            23830..25749
                     /locus_tag="VXE25_001327"
     CDS             23830..25749
                     /locus_tag="VXE25_001327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001136177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit"
                     /protein_id="HEV0771784.1"
                     /translation="MPQQASGMKQDGVLAKLGRNLTAEAREGKLDPVIGRNKEIQETS
                     EILSRRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGLEAGT
                     QYRGSFEENVQNLVNEVKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADILKPALSR
                     GELTVIGATTQDEYRNTILKNAALARRFNEVKVNAPSAENTFKILQGIRDLYQQHHNV
                     ILPDEVLKAAVDYSVQYIPQRSLPDKAIDLVDVTAAHLAAQHPVTDVHAVEREIETEK
                     DKQEKAVEAEDFEAALNYKTRIAELEKKIENHTEDMKVTASVNDVAESVERMTGIPVS
                     QMGASDIERLKDMAHRLQDKVIGQDKAVEAVARAIRRNRAGFDEGNRPIGSFLFVGST
                     GIGKTELAKQLALDMFGTQDAIIRLDMSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTE
                     RVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFKNTVVIATSNAGF
                     GYEANLTEDADKPELMDRLKPFFRPEFLNRFNAVIEFSHLTKEDLSKIVDLMLTEVNQ
                     TLAKKDIDLVVSQAAKDYITEEGYDEVMGVRPLRRVVEQEIRDKVTDFHLDHLDAKHL
                     EADMEDGVLVIREKA"
BASE COUNT         8025 a         4632 c         5802 g         7617 t
ORIGIN      
        1 attttttctg tctaactttt ggggtcagta cactttggct tttaaaccat tatcactatc
       61 aagatagttg taaaaatgca gaaggtggtt tgattttatc aagatatgca ggtcctggta
      121 gtcaccgcta ccctgttggt ttttcagggg atactattat tagttggaat tccttaagat
      181 ttcaacccta ttttacagcg acagcatcta atatcggtta tagttggtgg agtcatgata
      241 tcggtggaca tatgttgggg gattatgacg aagagctaca aactagatgg ctacagtttg
      301 gtgtttttag tccgattact cgattacata gttctagaag tccttttaat agtaaagaac
      361 cttggttctt ttcagaaaca acatctaaga ttatgaagaa ataccttcgt ttgagacatc
      421 agatgattcc ctatctatat accatgaatg taaagacaca tgaggaaggt gccccattaa
      481 tcagtccaat ctattatttc tatccagaga ataatgagag ctataatgtt ccaaaccaat
      541 acttttttgg aacagaactg atggtggctc ccattgtaga aaagatggat ttgacattcc
      601 aatctgcaaa agtagatgta tggttccctg aaggtgaatg gtatgacttc ttttcagaga
      661 aaaaatacac aggtggtgtg aagttaagtg tttataggga catctcgact acgcctgtgt
      721 ttgcaaaaag tggtgcaatc attcccttgg ttggttctga gataggtatg ggtgttgatt
      781 tacctgaagt tgtagattgg tatgtattcc cagggaaaca acattctttt gaaatgcttg
      841 aagatcaaaa tggtcaaaga tataaaacaa gattatcaat cgattgggaa atgggaatgg
      901 tagagttagc attacaagga gattctagta tcgttccaag caatagaaaa catagaattc
      961 attttaaagg aacgaatgtg tctataattg aattgccaaa taagaatgat acagctaaat
     1021 ttgaatggaa agataataaa aggacatctt taaatgacga agtttttaga ctactaaaga
     1081 cagcttctct tccatatgaa ttaaaagata gattgttaaa tcaattcatc aatgcgaaaa
     1141 actctcatga cttaatgaat atcttgcatc atcaggataa ggaattgaga gggagtttgt
     1201 tggaaatgat atttactagc caaaactaat tgaaataatt agaaagtcat ttgtttagtg
     1261 tatatgaaga ttctgtatgg tattcgttat cactggtcac attgaaaatg tgaaataagc
     1321 acctacaaca tagactttac aacacttcat gtttcatatc atggggtgtt tttctattta
     1381 agtcaaagcc catcaaaaaa tctcactatt catcaggtta aaggaaacct aatcatagtg
     1441 agattgtgaa ttatagtaga gtttgtatcg cctcttcaat ttgttttggg tctgtttttg
     1501 aagaaaagcg ttcaaagact tgcccatctc gaccgatgag aaacttagag aaattccatt
     1561 cgattcgttt tcctagtggg ccagatttct ggtcttttaa ccagacatag agagggtctg
     1621 cttccttacc gttgacctta atcttggcaa aacgtgggaa ggtggtttga aaatgtaggc
     1681 tacagaaggc gttgatttcc tctgcgctgc cgggtgcttg tcccataaac tgattgcaag
     1741 ggaaatccaa tatttcgaag ccctgatctt gatagcgttc atagagttct tgaagtccct
     1801 ggtactgggg cgttaaacca catccagtag cagtgttgac aatcaagaga actttgccac
     1861 gatagctatc caagggagtt gcttggttat tttggttcaa aacggaaaaa tcataaagtg
     1921 aagtcatgag ggcctctttt ctttttctac attgtaacag tttttacttt tttcgtcgag
     1981 tcggatggaa gatattgttg aagaataagc cctcaatatg atagaaaccg tttacaaata
     2041 actttaaaaa tggtatgatt taattaaacc ggtttactta gttgctataa atctctaatt
     2101 tgagatttag ttcctattga ttttacaata tgtttattgg agtgtataca tgcaaacaaa
     2161 aacaaagaag ctcattgtga gtttgtcttc acttgtttta tcaggatttt tattaaacca
     2221 ttatatgaca gttggagcgg aagaaacgac tacgaatacc attcagcaaa gccagaagga
     2281 agttcagtat cagcaaaggg atacaaaaaa tttagttgaa aatggtgatt ttagtcagac
     2341 ggaggacgga agcagtccgt ggacagggag caaagctcag gggtggtcag cttgggtaga
     2401 ccagaagaat agttctgcag atgcctcaac tcgagtcatt gaggctaagg atggggctat
     2461 cactatctca agccatgaga aattaagggc agtggttcac cgtatggttc ctattgaagc
     2521 taagaaaaag tataaactgc gtttcaagat taaaacagat aataaagtcg ggattgccaa
     2581 agttcgtatc attgaggaaa gtggtaagga caagcgattg tggaattctg caacgacgtc
     2641 aggaacaaag gactggcaga ccattgaagc agactatagc ccgactttag atgttgataa
     2701 aatcaagctg gagttattct atgaaacagg aactgggact gtttccttta aggatattga
     2761 gctggtagag gtagcagacc agctttctga ggattctcaa acagataaac agcttgagga
     2821 aaagattgat ttaccaattg gaaaaaaaca tgttttttct cttgcggact atacttataa
     2881 ggtagaaaat cctgacgttg cttcagtcaa aaatggaatt ttagaacctc ttaaggaagg
     2941 gacaaccaat gtcattgtca gtaaagatgg caaggaagtg aaaaagattc ctttgaagat
     3001 tctagcctct gttaaggatg catacacaga ccgtttggat gactggaatg gcatcatcgc
     3061 tgggaatcaa tactatgatt ctaaaaatga acagatggcc aaattaaacc aggaattgga
     3121 aggaaaggta gctgatagcc tatctagtat ttcaagttag gcggaccgca cctatttgtg
     3181 ggaaaaattt tcaaattata aaatgtctgc aaatctgact gccacttatc ggaaattgga
     3241 ggagatggcc aagcaagtga ccaatccttc ttctcgttat tatcaagatg aaactgtcgt
     3301 tcgaacagtc agggattcca tggaatggat gcataaacat gtctacaata gtgaaaagag
     3361 cattgttggg aactggtggg attatgaaat cggtacacct cgtgccatca acaatacctt
     3421 gtctctgatg aaagaatact tctctgatga ggaaattaaa aaatatacag atgtgattga
     3481 aaaatttgta ccagatcccg aacatttccg aaagacgact gataacccat ttaaggctct
     3541 aggtggaaac ttagttgata tgggaagagt aaaagtaata gctggtttac tgcgtaagga
     3601 tgatcaagaa atttcttcta ccattcgctc gattgagcaa gtgttcaagt tggtagacca
     3661 aggtgaaggt ttttatcaag atggatccta tatcgaccat accaatgttg cctatacggg
     3721 tgcttatggg aatgttttga ttgatggcct gtctcaactg ttgccagtca ttcaaaagac
     3781 caagaatcca atcgataaag ataaaatgca aaccatgtac cactggattg ataaatcgtt
     3841 tgctcctttg ctggtgaatg gagagctgat ggatatgagt cgtggacgct cgatcagtcg
     3901 tgcaaatagc gaggggcacg tggccgcagt agaagtacta agagggattc accgaatagc
     3961 ggatatgtct gaaggagaaa ccaaacaacg tttgcagagt cttgtgaaga ccattgttca
     4021 atcggatagt tattatgatg tctttaagaa tttgaagact tataaggata tcagtttgat
     4081 gcaatccttg ttaagtgatg caggagtcgc aagtgttcca agaacaagtt acctatctgc
     4141 ctttaacaag atggataaaa cagccatgta caatgcagag aaagggtttg gatttggctt
     4201 gtcactcttt tccagtcgta ccttgaatta cgaacacatg aacaaggaaa ataaacatgg
     4261 ttggtatacg agtgatggga tgttctatct ttacaatggc gatttgagtc actatagcga
     4321 tggctactgg ccaacagtta atccatataa gatgcctggt acaacagaga cggatgctaa
     4381 gagagcggat agcgatacag gtaaagttct accgtctgct ttcgttggaa cgagcaaact
     4441 agatgatgcc aatgcgacag caaccatgga tttcaccaac tggaatcaaa cattgactgc
     4501 tcataagagc tggtttatgc tgaaggataa gatcgccttt ttaggaagca atatccaaaa
     4561 cacttcaaca gatactgctg caactacaat tgaccagaga aaactggaat caagtaatcc
     4621 atataaagtc tatgtcaatg ataaagaagc ctcccttaca gaacaagaaa aggattatcc
     4681 tgaaacccaa agtgtctttt tagaatcgtc cgattcgaaa aagaatattg gttacttttt
     4741 ctttaagaag agttcaatca gtatgagtaa ggctttgcaa aagggagcct ggaaggatat
     4801 caatgaagga cagtcagaca aggaagttga aaatgaattt cttacgatta gtcaggctca
     4861 taagcaaaat ggagattctt atggctatat gctcatccct aacgtgggtc gtgccacctt
     4921 caatcaaatg ataaaagagt tagaaagtag cctcatcgaa aataacgaaa cccttcagtc
     4981 tgtttatgat gccaaacaag gagtttgggg cattgtgaaa tatgatgatt ctgtctctac
     5041 tatttccaac caattccaag ttttgaaacg tggagtctat accattcgaa aagaagggga
     5101 tgaatataag attgcctact ataatcctga aacccaggaa tcagctccag atcaggaagt
     5161 ctttaaaaag ctagagcaag cagctcagcc acaagtacag aattcaaaag aaaaggaaaa
     5221 atctgaagag gaaaagaacc attcggatca aaagaatctc cctcagacag gagaaggtca
     5281 gtcaatcttg gcaagtctag ggttcttgct acttggggcg ttttatttat tccgtagagg
     5341 aaagaacaac taatttgttc atcatctaga tgaattacat gaaactgtgg aaaatagaaa
     5401 aaatccgaag aaggccaaat atcttcggat ttttctttta aaaaagataa gttgatactt
     5461 atctttttta cttcattatg tgactatagc gttttgaaac tagaatagga cgtcataact
     5521 gctaaaagat ttctataaat tcatttgatt ttcctaatca atttgttcgt atcctatttc
     5581 actccactat attagtccgt ctcgctccgt gaggtgcgcg tcgaaggtta taccaaaaaa
     5641 actccaaacg cgatacaata aaggtgttca atccaattgt aaagcgaaag gagaaaaaat
     5701 atggcacaaa aggctcatag tttatctcac acaaagtgga ggtgttctat cacattgtgt
     5761 tcacccctaa gtatagacga aaagtcatct ataatcaata tagaagtagt ttaggcgaaa
     5821 tatttcatcg cttgtgtagt tataaaggtg ttgaaatgat cgagggtcac ttaatgccag
     5881 accatgtaca catgttagtc agtattccgt cgaggctaag tgtttcaagt tttatggggt
     5941 atttaaaagg caaaagtgca ctcatgatgt ttgacaaaca cgccaatctc aagtacaagt
     6001 ttgggaatcg gcatttctgg gcggaaggtt attatgtaag tccagtaggg cttaatgaag
     6061 ccacaattaa gaaatatagt caagattaaa gaaattatcg agtggatgat ttcttcacga
     6121 gtatgaaaat ttgagaacga gtaaagcatg atatatagta aaatgaaata agaacaggac
     6181 aaaatcgatc aggacagtca aatcgatttc taacaatgtt ttagaagcag aggtgtacta
     6241 ttccagtttc aatctactat aacactagat aaattgagtg taaaagaata tgaggatccc
     6301 tttagggata gtggtaagta ataccaaagt ctcttaaaga ggcaagtgac gagtcaagag
     6361 caataaggct tgaacaacgt gaaagccagc gtctttaggc gctggctgat gatttgggct
     6421 tatagctctg agataaacca cccgttagac gggtagttat gattttatct gagtgtaata
     6481 tactgttggg caatctcgct gatgcggtca aagttgcctt gggaagcgag tttattgagt
     6541 tcgccaccaa ttccaacggc atctgcacca gcagcgaacc attgagggat gttgtttagg
     6601 ccgactcctc cggttaccat tacggaaact tgtgggatcg gtgccttgac tgcagagata
     6661 tatgctggac tgagagtact acctgggaag agtttgatga tttcactacc ggcttcaagt
     6721 gcagtcgtga tctctgtgag ggtaatacag cctggaatgt acggtgtgct gtagagattg
     6781 cacattttcg cagtttcagc atggaaagat ggagaaacaa cgtaatttgc tccagctaga
     6841 atggcatctc tagcagttac ggcatcaagc acagtacctg caccgataca aacactctga
     6901 tcgtcctgat acaagtctac aagttccttg atgatttgtc ctgcatactg attggtatag
     6961 gcgatttcaa tagctttgat accgcccttg atacaagcaa tcgaggcttg tagtccttct
     7021 tcctttgtat ttcctcgaat gacagcgaca attttctgtt tttttagttc aataatcgta
     7081 tctgatttgg tcatgtaatt ctcctaacga atgatatctt gtgcatttgc cagtaaattt
     7141 tcaatactag ttgcggaagt ggagagatgg tctcctggaa gagtgcattt gagagttgcg
     7201 ctcgcaactg caaagtcaat ggtagttttt agggaggaat gatggagtag ttggtaaagg
     7261 gcaccagata taaaggcatc cccgctacca attcgttgat agactgcagt ttttagttgg
     7321 acagactctt caaatcgttc ttccagagca taggcttgat agacattttt gtcttgctca
     7381 tcactagagc ggagggtatg gaaaatggcc ttgaaaccat aggcttcttt taaaagtcgc
     7441 atgcgatttt ccacctcttc taggctagca ctgtctcttg gaaacatctc tagattttgg
     7501 tcatcaatca tgagaggatc aataccgaag caatagtcag taaaacgtgc aaacttagaa
     7561 aattcatact tggcttctag gactgaaatc atctttgttc tcagattgag atccattgaa
     7621 acgacaattc ctcggcgctt ggcttcttcc aagagtagga gaaggatcgc acggacctct
     7681 tgaccgatag ctacggtgat tccactaaaa tgaaaatggc taatcccctg aaagagagaa
     7741 tccatatcta gcatgtttgg ccgaatctgg ctgatactcg tatgcttacg atcgtagaaa
     7801 acttcacttt gacgacaacc aaagccgttc tccaaatagt agaggccgat tcgatcgcca
     7861 agccgacaga ttgaactggt atcgatttgg tgctgtttca agaatgtgag aaaacgatct
     7921 ccaatctcgt tggcagggag tgcggtaaag actttcgttg agatacccag ggcttgcaaa
     7981 ttacaagcga tgttaatttc tgatccgcca aaataagtcg aactggcaac atgatcgccg
     8041 atactggtgg catctaatgg tgagattcga attaatggtt cgccaaacag taatattttc
     8101 gtcatccatt agttcctttc tggtttagaa tagctttact tggctaatac ttctttcaaa
     8161 taagcagcga cttcatcatc ttggcagttt tcaaagaagt attcttggaa atatttgcca
     8221 gagatggtgt ctttgaggaa gtcttggtcg attgttttaa ggatggtcat caaatcattg
     8281 tgggtgattt gtttcacctc gtttaagata cgagcgttgc gttgttcagg gattacacgt
     8341 tctcttgggt agccaccgcc catttcttca gcaaataagc gatcaaacat caatttgagg
     8401 gtcagttctg ccccccagcc aaatcctttg gcataaggga tagacaaggc gttaccacca
     8461 ttgatttgag aataaaggta agcgtcagtt gggtccactg ctagaccaca gacaacacca
     8521 gggaagctgt ttaaagcaag catagcccct acacccgtac cacagccggt aacaacaaag
     8581 tcaactgcct ttgtatttaa aaggatggca gccattagtc cgttctgcac ataagttaat
     8641 tgactttctc cttcttctcc acgcatacca tagttaaata attggtagtc ttttttatct
     8701 gtcgcttctt ttagactatc gtaaataatg tgattcttgc tagcttgact attttcattg
     8761 attaatgcga ttttcataag atcttctttc tatttttact caggttgttt tccgatgtag
     8821 gctaagatac cgccatctac atataggatg tggccgttga caaaattgct ggcatcacta
     8881 gcgagaaaga cagcagggcc catcaaatct tcaggatttc cccaacgtgc agcaggtgtt
     8941 tttgcaatga tgaactggtc aaatgggtgg cgagaaccat cttcttgcaa ctcacgaaga
     9001 ggtgctgttt gaggagtggc aatataaccc ggtccaattc cgttacattg gatattggct
     9061 ccaccgtatt cagacgcaat gttgcgggtc aacattttca agcccccttt agcagcagca
     9121 taagcgctaa ctgtttcacg tcccagttcg ctcatcatcg aacaaatatt gataattttt
     9181 ccatgccctt tctttatcat agaaggaata actgcctttg aaacgataaa tggtgcgttt
     9241 aagtcaatat cgatgacctt acggaaatca gcggcgctca tttcgcacat tggaactcgg
     9301 cggataatac cagcgttatt aacgaggatg tcaatgacac caacctcttg ttcgatttgc
     9361 ttgaccatgg cttggatacc gtcctcgtct gtcacgtcac agacatatcc atgggcttcg
     9421 atgccaactt cacgataagc ttcaatccct ttattgacca gatcttgatt gatatcgtta
     9481 aagacaatag tagcgccggc ttcagcgtag gatttggcaa tagcaaatcc aattccataa
     9541 gaagcgccgg tgatgagagc aatttttcct tttaaagaaa actgctcaat tgagaatgat
     9601 gtatttgtca tttgatactt cctttcaaat ttgttaagac ttctctataa tcaaattata
     9661 ttctagtaaa ccggttttgt caataaataa atatttttat ttataaaaag gtttgttttc
     9721 ctaaaaaaac ggaagatttt gaaatttctg cctattaaaa tggttaaaaa gataatgaaa
     9781 gcgctaatat ttttttaaaa aaactattga caagataaaa ataaaggatt acaatgggga
     9841 atataaagta aaccggtaaa cctaaacaag aaaggagaaa agatgaaaat tgtacttgta
     9901 gggcatggac attttgctac agggatttat agttctttac aattgattgc aggtaatcaa
     9961 gaaaatgtgg aggcgattga ctttgtggaa ggaatgtcag cagatgaact caagcaaaaa
    10021 atcttacttg caatttcaaa tgaagaagaa gttttaatcc taagtgatct cttgggagga
    10081 tcgccattca aggtttcttc taccataatg ggagaaaatc cagtcaaaac aatgaatgtt
    10141 ctctcgggtt tgaacttagc catgttaatg gaagcagtct ttgctagaat ggctcatagc
    10201 tttgatgagg ttgttaataa atcagtagtg gcggcccagg gcggagtcgt aaatggtaaa
    10261 gaattgtttt caacggatgc agaggaagaa gatttcgaat tgggtattta aagggtaaaa
    10321 gaatgataaa aaaggttacg attgaaaaaa taaaatcgcc tgagcgcttc ttagaagtac
    10381 cacttctgac gaaagaagaa gtcggccagg caatcgataa ggttattcgg cagttagaac
    10441 tcaaccttga ctatttcaag gaagatttcc cgactccagc tacctttgat aatgtctatc
    10501 caatcatgga taacacggaa tggaccaatg gtttctggac aggagaactg tggttggctt
    10561 atgaatacag tcaacaggat gcatttaaaa acatcgctca taaaaatgtt ctttctttcc
    10621 tggatcgtgt caataagaga gtagaattgg atcaccatga tctcggcttc ttgtacacac
    10681 cgtcttgtat ggctgaatat aagataaatg gagatggaga ggctagagaa gcaaccttga
    10741 aagctgcaga taagttgatt gaacgctatc aagaaaaagg tggttttatt caagcttggg
    10801 gagacttggg caagaaagag cattaccgtt tgattatcga ctgcttgctc aatatccaac
    10861 tcttattctt tgcttatcaa gaaacaggcg atcaaaaata ctacgatatt gcagaaagcc
    10921 atttctatgc ttcagctaat aatgtaatcc gtgatgacgc ttcgtccttc cacaccttct
    10981 attttgatcc tgagacaggt caacccttta aaggtgtaac gagacaaggg tatagtgatg
    11041 attcatgctg ggcacgtggt caatcatggg gagtctatgg tattcctttg acttatcgtc
    11101 acttaaaaga cgagtcctgc tttgacttgt ttaagggtgt gaccaattat ttcttgaatc
    11161 gtctgccaaa agatcatgtg tcctattggg atttgatttt taatgatggt agtgatcaat
    11221 cacgagattc ttcagcaaca gctatcgccg tctgtgggat tcatgaaatg ctaaaacatc
    11281 tcccagaggt ggatgctgac aaagatattt ataaacatgc tatgcatgcc atgcttcgtt
    11341 ccttgatcga acattatgca aatgatcaat ttacccctgg tgggacaagt ctcctccacg
    11401 gtgtgtactc atggcattca ggtaaaggag tggatgaagg caatatctgg ggtgactact
    11461 attatctaga agcccttatc cgtttctaca aagactggaa cctatattgg taggaggaga
    11521 aatatgacaa tgccaaatat tattatgacc cgtatcgatg aacggttgat tcatggacaa
    11581 ggacaacttt gggtaaaata cctaggttgt aatacggtca ttgttgccaa tgacgaagta
    11641 agcacggaca agatgcaaca aactctgatg aaaacagttg tgccagactc agttgccatg
    11701 cgtttcttcc ctttgcaaaa ggtgattgat atcattcaca aggctaatcc tgctcaaacg
    11761 atctttatcg ttgtaaagaa tgtgaaggat gctttaacct tggtagaagg tggtgtccct
    11821 atcaaagaaa tcaatattgg gaacattcac aatgctactg gtaaagagca agtgacacgc
    11881 tccatcttcc tgggtgaaga ggacaaggtg gccctcaagg aattgagcca aactcatcaa
    11941 gtaacattta atacgaaaac aactccaaca ggaaatgatg gagctgttca agtcaacatt
    12001 atggactata tttaaaagag gagatcgtta tgtcgattaa tgtatttcaa gcgattttaa
    12061 ttggattatg gacagctttc tgttttagtg gaatgctgtt aggaatttac accaatagat
    12121 gtattgttct gtcatttggt gtcggaatta ttctaggtga tctgcctact gctcttgcaa
    12181 tgggagctat tggtgaattg gcttatatgg gattcggtgt tggtgctgga ggtactgttc
    12241 caccaaaccc aatcggacct ggtatctttg gtaccttgat ggctatcact agtgctggta
    12301 aagtcagtcc agaagcggct cttgccctct ctactccgat tgctgtggcg attcaattct
    12361 tacaaacttt cgcctacact gtacgtgctg gtgcgcctga aacggcgatg aagcacttga
    12421 aaaaccataa tttgaagaaa ttcaagttca ctctaaatgc aacaatttgg ttgtttgcct
    12481 ttattggatt taccttgggt tgcttgggtg ccctttcaat ggataccttg ttgaaactcg
    12541 tagactacat tccaccggta ttacttacag gtttgacagt tgctggtaaa atgctcccag
    12601 ctatcggttt tgcgatgatc ttgtcagtga tggctaagaa agagttgatt ccctttgtct
    12661 tgttgggata tgtttgtgca gcttatctaa acatcccaac aattggtatt gcaattgtag
    12721 gtactatctt tgctttgatt gaattttata acaagccaaa aacagcggat catgtggtag
    12781 aggaggaagc acacgatgac tggatctaac aaattaacaa aacgtgatta tcttaaaacg
    12841 tctttgcggg cattcttttg tcaaaatgga tttaactata gtaactatca agggttggga
    12901 tatgccaatg tgatgtatcc tgctttgaaa aaacactatg gagaggatca ggaagttttc
    12961 taccaagcct tggaagaaaa ctgtgaattc tataatacca acccacactt cctgcctttt
    13021 attaccagct tgcatcttgt aatgttggaa aatggccgtc cggcaaaaga aacacgtagc
    13081 atcaagatgg ccttgatggg accattggca ggtattgggg attctctttc tcaattctgt
    13141 ttagctccat tgttctcaac catcgcagct tcgtttgctc aagaaggctt ggttgccggt
    13201 ccaatcttgt tcttccttgc gatgaatacg attttaacag cgattaaatt gtcaactggt
    13261 ctgtatggat acaaactagg aacaactgtg attgataaac taagcgaaca gatggcaacg
    13321 atttctcgta ttgccaatat tatcggtgta accgtaattg ctggtttggc agcgacatct
    13381 gttaagatta tggtgccgat tacctttgct gcaggggaag ttaaagcaga cgctaaacaa
    13441 agtatcgtaa gtattcaggg aatgcttgat aaggttgctc cagctcttct accagcccta
    13501 tttacacttt tagtttacta cttgatcaaa gaaaagaaat ggacaacata taaactcgtt
    13561 attttaacag ttatcatcgg aattatcgga agctggctta agattatagc ttaatggata
    13621 caacattgtt ttatggaata gtgattgtct tggcagtgag tcccctttta ctgtcaagct
    13681 ttcattctat tcgtcagcaa aagttgcttc gcaaacagat ggagcaacga caagagtatt
    13741 tagcttcttt aacatctggt gatgaagtgt tgttattgtc tggaattcat ggaaaaatca
    13801 tttctatcaa agatgacttg gtctccttgc agattgcaaa aggtgtggtc atctatgtag
    13861 aaaaggaaag tgtaatggga aagacaaaag aactgctttt taagtagttc tttttctggt
    13921 aatagataat gaaagaagaa agaagacaat tttttgaaag agtcgatgga aaccaatgtc
    13981 gtgattatat cttgtcccac tgttcaaaag actatgagaa agtcaagagt tcccttgaac
    14041 gcttgatgga caatcgtttt atgtttgata gtccttggga tatggagcct tgttcaaaaa
    14101 tccatcaaat ccagccgatg gtatgggatc aagtatttga agatgatcca gaatggtctt
    14161 atatgctcaa tcgacaagaa tatctcttgc agtttatgat agggtatctg gtagaaggag
    14221 ataaggacta tattcaaaag tgcaagttct ttctatttga ttggattgag caggtgagag
    14281 aattttctcc tcaatccttg atgactagaa cattggatac gggtattcgt tcctttactt
    14341 ggttgaaact actcttgctt ctcttgaaat ttgacttgct agaggagaaa gaactagaga
    14401 aaattttggt cagtctagaa aagcagattg actttatgaa aagctactat cgcgccaagt
    14461 acacccttag taactggggg attttacaaa caattccgat gcttgctatc tatcatttct
    14521 tttcagataa gatggaccta gaagaagctt accattttgc ttcagaggag ttgaaacagc
    14581 aaattgagac acagatttta ggagatggaa gccagtttga acagtcgatt ctctatcatg
    14641 tagaggttta taaagccttg ctggatttgt gtctcttgct tccagacttg caagatagtt
    14701 accaagagtt gctggaaaag atggcgacct atattcaaat gatgacaggc ttagatggac
    14761 gaactttggc ttttggtgat agcgattcta cagaaacgac agaaattttg agcctgtctg
    14821 ctgtggtttt gaacaaggaa gaccttctta acggtctgga tgttaaagtt gatttgctta
    14881 gcctcttgtt cctggggcga gaaaaggtca agcgactgca ggaatttgaa aggagagctt
    14941 ggcagcctaa gtccatgatc tttgaagact ctggacatgt ctgtattaag gatgaacatc
    15001 gttatctatt tttcaaaaat ggtccgctag gaagtgccca tagccatagt gacgagaata
    15061 gtttttgctt acagtatcaa ggccaaccta ttttcataga tgctgggcgt tattcttatc
    15121 gggagatata tgaacgttat ctcttaaaga gtgcttggag tcattcgacc tgcattgtag
    15181 atgggaaagc tccggaaaga atcacgggat cctgggaata tgaatactat cctcactccc
    15241 tgttttgtca ccataaagaa agggagggaa tgcattatat tgaaggggct tattggtcag
    15301 cagaacctga tttgccttat cttcacagaa gaaaaatcct catgttggta gaggatgtct
    15361 ggctcttggt ggatgacatc aggtgtcaag gtcagcatga ggcgttgact cagtttatcc
    15421 ttgacaagga tgtgacctat caagatggga aaatcaatca gttgagacta tggagtgaag
    15481 ttgattttga tttggaagat accatcattt ctcctaaata caatgagctt gaaagaagta
    15541 gcaaactcac caagcgccaa ttctttgaga atcagatgct ggattatacc atcattgcgc
    15601 atgagagttt tgaaatcatc cgtcattctg tctaccagac agatgatcgt gaagtggaaa
    15661 atgctctggc ttttgaagtg aaaaatgacg aaacagacaa gctgattctg ttattaagcg
    15721 aggatattgg tgtaggtgaa aaattgtgcc tcgttgacgg aacaaaaatg cgtggaaaat
    15781 gtctagtata tgataaaata aatgagagaa tgattcgctt gcagtgctag aaataggcat
    15841 tttgaatagt gaacatgtta taataagtat tagtaggagg tgttttagat tggagaagaa
    15901 actgaccata aaagacattg cggaaatggc tcagacctcg aaaacaaccg tgtcatttta
    15961 cctaaacggg aaatatgaaa aaatgtccca agagacacgt gaaaagattg aaaaagttat
    16021 tcatgaaaca aattacaaac cgagcattgt tgcgcgtagc ttaaactcca aacgaacaaa
    16081 attaatcggt gttttgatcg gtgatattac caacagtttc tcaaaccaaa ttgttaaggg
    16141 aattgaggat atcgccagcc agaatggcta ccaggtaatg ataggaaata gtaattacag
    16201 ccaagagagt gaggaccggt atattgaaag catgcttctc ttgggagtag acggctttat
    16261 tattcagccg acctctaatt tccgaaaata ttctcgtatc atcgatgaga aaaagaagaa
    16321 aatggtcttt tttgatagtc agctctatga acaccggact agctgggtta aaaccaataa
    16381 ctatgatgcc gtttatgaca tgacccagtc ctgtatcgaa aaaggttatg aacattttct
    16441 cttgattaca gcggatacga gtcgtttgag tactcggatt gagcgggcaa gtggttttgt
    16501 ggatgcttta acagatgcta atatgcgtca cgccagtcta accattgaag ataagcatac
    16561 gaatttggaa caaattaagg aatttttaca aaaagaaatc gatcccgatg aaaaaactct
    16621 ggtatttatc cctaactgtt gggccctacc tctagtcttt accgttatca aagagttgaa
    16681 ttataacttg ccacaagttg ggttgattgg ttttgacaat acggagtgga cttgcttttc
    16741 ttctccaagt gtttcgacgc tggttcagcc ctcctttgag gaaggacaac aggctacaaa
    16801 gattttgatt gaccagattg aaggccgcaa tcaagaagaa aggcaacaag tcttggattg
    16861 tagtgtgaat tggaaagagt cgactttcta aaatgaagga aaatgacttg caatctctgt
    16921 taagaaataa aataatccca cctagcttgt tctaggtggg attatttgcc tatgaaatga
    16981 gaaattatgg gagcaagctc ctaaatcaac tgtttttgat ctacttcttt aactacttga
    17041 taaaagttat agaagtaggc caaacttgaa atgatggtta cgactaggaa tattgaaaat
    17101 ttccattgga cagggttggt taaaagttgt ggaaaggata tgaggagaaa gaagagggct
    17161 gcgttgagga caggtatccg ttttgattgt attttctcaa gtcctttatt gagcgcagga
    17221 agaaagagga gtaggagtag taaaactgta tgagaaacag ctcctgaaat aagggcaaag
    17281 aaaaggaaaa tactgataaa aacatgaatg atcagtagtc tagctagtga tttcataagg
    17341 tacctcctaa tcctggtctt ttttagctct tgcaatacga agtgagtcga caatatgtat
    17401 catcactccg aaaaagaaag ctcccagtat agttttaaaa atatgttttg tatttagaag
    17461 agaactgata aaatttggat tttcacttgt tagggtatca atgagtggaa ttataaaaaa
    17521 tatcactgtt ccataaatcg aacctgcttt cagaccagga taacgtaact gtctcttttc
    17581 ttttttcata gggcacctcc taatcctcat cttgattttt cttagttttt gcaatgcgac
    17641 gggagatgag gaactgtatg ctcgctccga agaaaataga accgagaatg cttgatacac
    17701 catttcttat agtgagaaga gaatgaaaat agtcctgacc ttcacctatg agtatcctga
    17761 gaagaggagt tataaaaaac atccatagac caaagaacaa acctgctttc agacctgggt
    17821 aatgtagttg cttactttct ttctcgctca gcatgtctgg atcaatagct gtaatccctg
    17881 tttttttcat ttggtaggtg acatagccag cagcgatgag ggcaatcact aaaatcagag
    17941 gaggatagat tagagccact tcttgagggt atttataggc cagaaggagt ggaataagat
    18001 ttccgaaaat catcagataa aagaggatga taaagacttg gttcccaata cgatcggcct
    18061 cacgccgttt gtattcgtca aggggaccag aaataccgta tgtgcgtttg atcagttttt
    18121 cagtgaaggt ttcttttttc atgagtttgc tcctttttta aaaatcatcc tcccaaaaga
    18181 gactgttgag gtcagtttgg aggctgcggg cgagattgag acagagttcc aaggttggat
    18241 tgtacttgtc gttttcaatc atattgatag tctgtctcga gacaccgata tccttggcga
    18301 gctcgagctg ggaaatgccc agttccttgc gaaattcttt cacacgattc atctggtctc
    18361 ctttctgatt tgtgtcgtat atatttgact ttattatagt cttttaaaca taaagtgtca
    18421 agtatttttg acatattttt tgaagaaata gtagtctcct tgtcctattt gtctgacaag
    18481 tgcaagctgg tcggatttgt ggtaaaatag ataagatatg acaaaagaat ttcatcatgt
    18541 aacggtctta ctccacgaaa cgattgatat gcttgacgta aaacctgacg gtatctacgt
    18601 tgatgcgact ttgggtggag caggccatag cgagtattta ttaagtaaat taagtgaaaa
    18661 aggccatctc tatgcctttg accaggatca gaatgccatt gacaatgcgc aaaaacgctt
    18721 ggcaccttac attgagaagg gaatggtgac ctttatcaag gacaacttcc gtcatttaca
    18781 ggcacgtttg cgcgaagctg gtgttcagga aattgatgga atttgttatg acttgggagt
    18841 gtctagtcct caattagacc agcgtgagcg tggtttttct tataaaaagg atgcgccact
    18901 ggacatgcgg atgaatcagg atgctagcct gacagcctat gaagtggtga acaattatga
    18961 ctatcatgac ttggttcgta ttttcttcaa gtatggagag gacaaattct ctaaacagat
    19021 tgcgcgtaag attgagcaag cgcgtgaagt gaagccgatt gagacaacga ctgagttagc
    19081 agagattatc aagttggtca aacctgccaa ggaactcaag aagaaggggc atcctgctaa
    19141 gcagattttc caggctattc gaattgaagt caatgatgaa ctgggggcgg cagatgagtc
    19201 catccagcag gctatggata tgttggctct ggatggtaga atttcagtga ttacctttca
    19261 ttccttagaa gaccgcttga ctaagcaatt gttcaaggaa gcttcaacag ttgaagttcc
    19321 aaaaggcttg cctttcatcc cagatgatct caagcccaag atggaattgg tgtcccgtaa
    19381 gccaatcttg ccaagtgcgg aagagttaga agccaataac cgctcgcact cagccaagtt
    19441 gcgcgtggcc agaaaaattc acaagtaaga gggaaaaaga tggcagaaaa aatggaaaaa
    19501 acaggtcaaa tactacagat gcaacttaaa cggttttcgc gtgtggaaaa agctttttac
    19561 ttttccattg ctgtaaccac tcttattgta gccattagta ttatttttat gcagaccaag
    19621 ctcttgcaag tgcagaatga tttgacaaaa atcaatgcgc agatagagga aaagaagacc
    19681 gaattggacg atgccaagca agaggtcaat gaactattac gtgcagaacg tttgaaagaa
    19741 attgccaatt cacacgattt gcaattaaac aatgaaaata ttagaatagc ggagtaagat
    19801 atgaagtgga caaaaagagt aatccgttat gcgaccaaaa atcggaaatc gccggctgaa
    19861 aacagacgca gagttggaaa aagtctgagt ttattatctg tctttgtttt tgccattttt
    19921 ttagtcaatt ttgcggtcat tattgggaca ggcactcgct ttggaacaga tttagcgaag
    19981 gaagctaaga aggttcatca aaccacccgt acagttcctg ccaaacgtgg gactatttat
    20041 gaccgaaatg gagtcccgat tgctgaggat gcaacctcct ataatgtcta tgcggtcatt
    20101 gatgagaact ataagtcagc aacgggtaag attctttacg tagaaaaaac acaatttaac
    20161 aaggttgcag aggtctttca taagtatctg gacatggaag aatcctatgt aagagagcaa
    20221 ctctcgcaac ctaatctcaa gcaagtttcc tttggagcaa agggaaatgg gattacctat
    20281 gccaatatga tgtctatcaa aaaagaattg gaagctgcag aggtcaaggg gattgatttt
    20341 acaaccagtc ccaatcgtag ttacccaaac ggacaatttg cttctagttt tatcggtcta
    20401 gctcagctcc atgaaaatga agatggaagc aagagcttgc tgggaacctc tggaatggag
    20461 agttccttga acagtattct tgcagggaca gacggcatta ttacctatga aaaggatcgt
    20521 ctgggtaata ttgtacccgg aacagaacaa gtttcccaac gaacgatgga cggtaaggat
    20581 gtttatacaa ccatttccag ccccctccag tcctttatgg aaacccagat ggatgctttt
    20641 caagagaagg taaaaggaaa gtacatgaca gcgactttgg tcagtgctaa aacaggggaa
    20701 attctggcaa caacgcaacg accgaccttt gatgcagata caaaagaagg cattacagag
    20761 gactttgttt ggcgtgatat cctttaccaa agtaactatg agccaggttc cactatgaaa
    20821 gtgatgatgt tggctgctgc tattgataat aatacctttc caggaggaga agtctttaat
    20881 agtagtgagt taaaaattgc agatgccacg attcgagatt gggacgttaa tgaaggattg
    20941 actggtggca gaatgatgac tttttctcaa ggttttgcac actcaagtaa cgttgggatg
    21001 actctccttg agcaaaagat gggagatgct acctggcttg attatcttaa tcgttttaaa
    21061 tttggagttc cgacccgttt cggtttgacg gatgagtatg ctggtcagct tcctgcggat
    21121 aatattgtca acattgcgca aagctcattt ggacaaggga tttcagtgac ccagacacaa
    21181 atgattcgtg cctttacagc tattgctaat gacggtgtca tgctggagcc taaatttatt
    21241 agtgccattt atgatccaaa tgatcaaact gctcggaaat ctcaaaaaga aattgtggga
    21301 aatcctgttt ctaaagatgc agctagtcta actcggacta acatggtttt ggtagggacg
    21361 gatccggttt atggaaccat gtataaccac agcacaggca agccaactgt aactgttcct
    21421 gggcaaaatg tagccctcaa gtctggtacg gctcagattg ctgacgagaa aaatggtggt
    21481 tatttagtcg gggtaaccga ctatattttc tcggctgtat cgatgagtcc ggctgaaaat
    21541 cctgatttta tcttgtatgt gacggtccaa caacctgaac attattcagg tattcagttg
    21601 ggagaatttg ccaatcctat cttggagcgg gcttcagcta tgaaagactc tctcaatctt
    21661 caaacaacag ctaaagcttt ggagcaagta agtcaacaaa gtccttatcc tatgcctagt
    21721 gtcaaggata tttcacctgg tgatttagca gaagaattgc gtcgcaatct tgtacaaccc
    21781 atcgttgtgg gaacaggaac gaagattaaa aacagttctg ctgaagaagg gaagaatctt
    21841 gccccgaatc agcaagtcct tatcttatct gataaagcag aggaggttcc agatatgtat
    21901 ggttggacaa aggagactgc tgagaccctt gctaagtggc tcaatataga acttgaattt
    21961 caaggctcgg gctctactgt gcagaagcaa gatgttcgtg ctaacacagc tatcaaggac
    22021 attaaaaaaa ttacattaac tttaggagac taatatgttt atttccatca gtgctggaat
    22081 tgtgacattt ttactaactt tagtaggaat tccggccttt atccaatttt atagaaaggc
    22141 gcaaattaca ggccagcaga tgcatgagga tgtcaaacag catcaggcaa aagctgggac
    22201 tcctacaatg ggaggtttgg ttttcttgat tacttctgtt ttggttgctt tctttttcgc
    22261 cctatttagt agccaattca gcaataatat gggaatgatt ttgttcatct tggtcttgta
    22321 tggcttggtc ggatttttag atgactttct caaggtcttt cgtaaaatca atgaggggct
    22381 taatcctaag caaaaattag ctcttcagct tctaggtgga gttatcttct atcttttcta
    22441 tgagcgcggt ggcgatatgc tttctgtctt tggttatcaa gtgcatctag ggattttcta
    22501 tattgtcttc gctcttttct ggctagtcgg tttttcaaac gcagtaaact tgacagacgg
    22561 tgttgacggt ttagctagta tttccgttgt gattagtttg tctgcctatg gagttattgc
    22621 ctatgtgcaa ggtcagatgg atattcttct agtgattctt gccatgattg gtggtttgct
    22681 cagttttttc atctttaacc ataagcctgc taaggtcttt atgggtgatg tgggaagttt
    22741 ggccctaggt gggatgctgg cagctatctc tatggctctc caccaagaat ggactctctt
    22801 gattatcgga attgtatatg tttttgaaac aacttctgtt atgatgcaag tcagttattt
    22861 caaactgaca ggtggtaaac gtattttccg tatgacgcct gtacatcacc attttgagct
    22921 tgggggattg tctggtaaag gaaatccttg gagcgagtgg aaggttgact tcttcttttg
    22981 gggagttggg cttctagcaa gtctcctgac ccttgcaatt ttgtatttga tgtaagaatg
    23041 gcaccctgat gtttcagggt gtttttgtgt ttaaatacac aatgaaaatc aaagaacaaa
    23101 ctagaaagct aactttaggc tgctcaaaat ataatagatt gaaactagaa tagtacacct
    23161 ctacttctaa aacattttta gaaatcgatt tgactgtcct gattgatttg tcctgttctt
    23221 atttcatttt actatacagt tttgagatgg ttgatagaac tgacgaagtc agctcaaaac
    23281 actgttttga ggttgtagac aaggcgaagc tgatgtggtt tgaagaggtt ttcgaagagt
    23341 gtaaaaaaat attggtcagt taaagtcaaa attcttgacc ttttctgacc aatgtagtat
    23401 attatgaacg taaggtaaat gaaagcctta ctagaacact tatttaaagt aaaatagaaa
    23461 gaggtgagtc tatgtttcat ctagcaatct tcagaggtaa agatagtcta ctcctgcttg
    23521 aaaaagaaaa accagaaata gtacgtaggg tagcggttta gctagtctaa attttttaaa
    23581 acaatggtca aagatagtca atatcagtaa tcataactaa gtaaacaaaa agaggtaaag
    23641 aatatgaata acaactttaa taattttaat aacatggatg atttatttaa ccaattgatg
    23701 ggtggtatgc gaggatatag ttctgaaaat cgccgttact taattaatgg acgcgaagtc
    23761 acacctgagg aatttgctca ctatcgtgcg actggtcaat taccaggaaa tgcagaaact
    23821 gatgtgtaaa tgccacaaca ggcatcaggt atgaaacaag acggtgtcct tgcaaaacta
    23881 ggtcgaaact tgacagcaga agcgcgtgag ggcaagttgg atcctgttat cggacgaaac
    23941 aaggaaattc aagaaacatc tgaaatcctc tcacgccgca ccaagaacaa tcctgttttg
    24001 gtcggagatg caggtgttgg taagacagca gttgtcgaag gtctagcgca agccattgtg
    24061 aacggagatg ttcctgctgc tatcaagaat aaggaaatta tttctattga tatctcaggt
    24121 cttgaggctg gtactcaata ccgtggtagc tttgaagaaa atgtccaaaa cttagtcaat
    24181 gaagtgaaag aagcagggaa tattatcctc ttctttgatg aaattcacca aattcttggt
    24241 gctggtagca ctggtggaga cagtggttct aaagggcttg cggatattct caagccagct
    24301 ctctctcgtg gagaattgac agtgattggg gcaacaactc aagacgaata ccgtaacacc
    24361 atcttgaaga atgctgctct tgctcgtcgt ttcaacgaag tgaaggtcaa tgctccttcg
    24421 gcagagaata cttttaaaat tcttcaagga attcgtgacc tctatcaaca acaccacaat
    24481 gtcatcttgc cagacgaagt cttgaaagca gcggtggatt attctgttca atacattcct
    24541 caacgtagct tgccagataa ggctattgac cttgtcgatg taacggctgc tcacttggcg
    24601 gctcaacatc cagtaacaga tgtgcatgct gttgaacgag aaatcgaaac ggaaaaagac
    24661 aagcaagaaa aagcagttga agcagaagat tttgaagcag ctctaaacta taaaacacgc
    24721 attgcagaat tggaaaagaa aatcgaaaac cacacagaag atatgaaagt gactgcaagt
    24781 gtcaacgatg tggctgaatc tgtggaacga atgacaggta tcccagtatc gcaaatggga
    24841 gcttcagata tcgaacgttt gaaagatatg gctcatcgct tgcaagacaa ggtgattggt
    24901 caagataagg ccgtagaagc tgtagctcgt gctatccgtc gtaaccgtgc tggttttgat
    24961 gaaggaaatc gcccaatcgg cagcttcctc tttgtagggt ctactgggat tggtaagacg
    25021 gagcttgcta agcaattggc actcgatatg tttggaaccc aggatgcgat tatccgtttg
    25081 gatatgtctg aatacagtga ccgcacagct gtttctaagc taattggtac aacagcaggc
    25141 tatgtgggtt atgatgacaa tagcaatacc ttaacagaac gtgttcgtcg caatccatac
    25201 tctatcattc tcttggatga aattgaaaag gctgatcctc aagttattac ccttctcctc
    25261 caagttctag atgatggtcg tttgacagat ggtcaaggaa atacagtaaa cttcaagaat
    25321 actgtcgtta ttgcgacctc aaatgctgga tttggctatg aagccaattt gacagaagat
    25381 gcggataaac cagaattgat ggaccgtttg aaacccttct tccgtccaga attcctcaac
    25441 cgctttaatg cagtcatcga gttctcacac ttgactaagg aagacctttc taagattgta
    25501 gatttgatgt tgactgaagt taaccaaacc ttggctaaga aagacattga cttggtagtc
    25561 agtcaagcgg ctaaagatta tatcacagaa gaaggttacg acgaagtcat gggggttcgt
    25621 cctctccgtc gagtggttga acaagaaatt cgtgataagg tgacagactt ccacttagat
    25681 catttagatg ctaaacatct ggaagcagat atggaagatg gcgttttggt tattcgtgag
    25741 aaagcctaag acagaatttt taggataaaa aagaaggagc cagctgaaaa aaactggttc
    25801 cttttgaggt acgacgggca tgtcgtgtag taggttgaaa ctagaatagt acacatctac
    25861 ttctaaaaca ttgttagaaa tcgatttgac tgtcctgaac gatttgtcct gttcttattt
    25921 cattttacta tatatctgaa tatctgaggt gtaagtcctc ggtgggcacc cactaccggt
    25981 gaacccaata gcgattccca agcctgacta tcgtgaggta gtggattaaa acggtctggg
    26041 gatagaccgt tttaagtctg acgctggaaa taagaa
//
LOCUS       DAVLHC010000028        25618 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.028, whole genome shotgun sequence.
ACCESSION   DAVLHC010000028 DAVLHC010000000
VERSION     DAVLHC010000028.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 25618)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 25618)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..25618
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.028"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            1..474
                     /gene="rlmH"
                     /locus_tag="VXE25_001328"
     CDS             1..474
                     /gene="rlmH"
                     /locus_tag="VXE25_001328"
                     /EC_number="2.1.1.177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018377683.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA
                     (pseudouridine(1915)-N(3))-methyltransferase RlmH"
                     /protein_id="HEV0771785.1"
                     /translation="MKVVTVGKLKEKYLKDGIAEYSKRISRFAKFEMIELSDEKTPDK
                     ASESENQKILEIEGQRILSKIADRDFVIVLAIEGKTFFSEEFSKQLEETSIKGFSTLT
                     FIIGGSLGLSSSVKNRANLSVSFGRLTLPHQLMRLVLVEQIYRAFTIQQGFPYHK"
     gene            518..591
                     /locus_tag="VXE25_001329"
     tRNA            518..591
                     /locus_tag="VXE25_001329"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:552..554,aa:Arg,seq:tct)
     gene            756..881
                     /gene="comC"
                     /locus_tag="VXE25_001330"
     CDS             756..881
                     /gene="comC"
                     /locus_tag="VXE25_001330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000799689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence-stimulating peptide ComC"
                     /protein_id="HEV0771786.1"
                     /translation="MKNTVKLEQFVALKEKDLQKIKGGEMRLSKFFRDFILQRKK"
     gene            902..2227
                     /locus_tag="VXE25_001331"
     CDS             902..2227
                     /locus_tag="VXE25_001331"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000362880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEV0771787.1"
                     /translation="MDLFGFGTVIVHFLIISHSYHFICKGQINRKELFVFGAYTLLTE
                     IVFDFPLYILYLDGLGIERFLFPLGLYSYFRWMKQYERDRGLFLSLLLSLLYESTHNF
                     LSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDEDYLYPFLKK
                     VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIA
                     LKQKKFEQKHLQNYTDEIVGLYNEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEV
                     LVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEFTLEVKDTITKLPIE
                     LLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFA
                     LGFSTKGRNRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE"
     gene            2224..2976
                     /locus_tag="VXE25_001332"
     CDS             2224..2976
                     /locus_tag="VXE25_001332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000866085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEV0771788.1"
                     /translation="MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEE
                     YIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNPYAIIVFITSRSEFATLTYKYQV
                     SALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
                     IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRK
                     NLEIVFYEDHRCPISRLKIRKLKDILEKKSQK"
     gene            3028..3099
                     /locus_tag="VXE25_001333"
     tRNA            3028..3099
                     /locus_tag="VXE25_001333"
                     /product="tRNA-Glu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:3061..3063,aa:Glu,seq:ttc)
     gene            3105..3178
                     /locus_tag="VXE25_001334"
     tRNA            3105..3178
                     /locus_tag="VXE25_001334"
                     /product="tRNA-Asn"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:3139..3141,aa:Asn,seq:gtt)
     gene            complement(3219..3761)
                     /locus_tag="VXE25_001335"
     CDS             complement(3219..3761)
                     /locus_tag="VXE25_001335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator
                     C-terminal domain-containing protein"
                     /protein_id="HEV0771789.1"
                     /translation="MQESNKRLKTKRTIENAMVQLLMEQPFDKISTVKLVEKAGISRS
                     SFYTHYKDKYDMIEHYQSKLFHTFEYIFQKHAHHKRDAILEVFEYLESEPLLAALLSE
                     NGTKEIQNFLRNKLHIMLSTDLQKRFMQLNLNTTELEYSSIYLTHALFGVCQTWIAHG
                     KKESSQEITDFLMKMLGDTN"
     gene            3940..4635
                     /locus_tag="VXE25_001336"
     CDS             3940..4635
                     /locus_tag="VXE25_001336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhgE/Pip family protein"
                     /protein_id="HEV0771790.1"
                     /translation="MIGISLIPDLYNIIFLSSMWDPYGQLSDLPVAVVNNDKEASYNG
                     NTMAIGKDMVSNLKENKTLDFHFVDEEEGKKGLEDGDYYMVVTLPSDLSEKTTTLSNI
                     QSTAAYQSLTSEQQTEISDSVSQNSTDSIQSAQSIVALVQDLQGSLENLQNQSSNLST
                     LKNQSNQVSPITSTSLIGLSSGLTEIQGDVTSKLVPASQSIASGVNAYTTGVDKVSQG
                     ASQLSEKKCHLDR"
     gene            4607..4708
                     /locus_tag="VXE25_001337"
     CDS             4607..4708
                     /locus_tag="VXE25_001337"
                     /inference="COORDINATES: protein motif:HMM:TIGR03057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771791.1"
                     /translation="MKKNATLTGSLNKLVSGSNTLTQKSSRLTAGVG"
     gene            4793..5473
                     /locus_tag="VXE25_001338"
     CDS             4793..5473
                     /locus_tag="VXE25_001338"
                     /inference="COORDINATES: protein motif:HMM:TIGR03057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhgE/Pip family protein"
                     /protein_id="HEV0771792.1"
                     /translation="MADGSGKLAEGGTKLTSGLEDLQTGLASLGQGLGNASDQLKSVS
                     TESKNAEILSNPLNLSKTDNDQVLVNGIAIAPYMISVALFVAAISTNMIFAKLPSGRH
                     PESRWAWLKSRAEINGIIAVLAGILVYGGVQLIGLTANHEMRIFILIILTSLVFMSMV
                     TTLTTWNSRIGAFFSLILLLLQLASSAGTYPLALTNDFFRSINPWLPMSYSVSGLRQT
                     ISINKSFS"
     gene            complement(5574..8126)
                     /locus_tag="VXE25_001339"
     CDS             complement(5574..8126)
                     /locus_tag="VXE25_001339"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YfhO family protein"
                     /protein_id="HEV0771793.1"
                     /translation="MKSFLKTYRTYFISFIIPVVIMSGVYLSQGIYWNSDNSPLLGDG
                     FHQYVIFDVALRNILHGNSSLFYTFTSGLGLNFYALSSYYLGSFLAPLVYFFDLTNMP
                     DAVYLTTLLKFGLIGLSTFFSLNKLFQSIPQTLKLALSTSYALMGFTVSQLEIKTWLD
                     VFILIPLIITGLHLLITEKKLLLYFTSLSILFIQNYYFGYMTVLFLIFWYLCQISWDF
                     KTRKSSVLDFIVISFLAGMASLIMTLPTLFDLQTHGEKLTEVTKFQTESSWYLDLFAK
                     QFIGSFDTTKYGAIPMIFVGLLPFILTILFFTLKSIRFHVKLIYIIFFAFLIASFYIE
                     ALDLFWQGMHTPNMFLHRYAWIFSTLLIYTAAEVLKRLKELKVWNFLVSLFLVVTGFL
                     ATIYLKSHYSFLTDLNILLTLEFLVVYSLLLLAVIKKFISVNLFAILISLFILVEMSL
                     NASSQMDGIAKEWGFASRSAYSRDIPAMESFSTYIGNQFTRTEKLQTQTGNDSMKFNY
                     NGISQFSSVRNRSSSSTLDKLGFKSSGTNLNLRYANNSILADSLFGIQYNISDSPIDK
                     YGFKDIYQKDNLTLYENQYSLPIAVASQSVYNDVKFNEHTLDNQASFLNQLANVNFDY
                     FSPIPYEKTEKIENTNDLISVTSSSNEDAAIQYQIEVPENSQVYLSFINLHFSNDKQK
                     KVDILVNGEKKTFTTDNVFSFFNLGYTKEKKTFNINVSFPGNSQVSFESPTFYRLDTK
                     TFTEAIQKIKEQPVTVSTSKNKVFATYDVQQDTSIFFTIPYDKGWSAYQDGKKIEIKQ
                     AQTGFMKVDIPKGKGTITLSFIPNGFITGAICSFTSLLLFGIYNHRRKSSKA"
     gene            complement(8188..9810)
                     /locus_tag="VXE25_001340"
     CDS             complement(8188..9810)
                     /locus_tag="VXE25_001340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEV0771794.1"
                     /translation="MLTVSDVSLRFSDRKLFDDVNIKFTEGNTYGLIGANGAGKSTFL
                     KILAGDIEPTTGHISLGPDERLSVLRQNHFDYEDERAIDVVIMGNEKLYSIMKEKDAI
                     YMKEDFSDEDGVRAAELEGEFAELGGWEAESEASQLLQNLNIPEELHYQNMSELANGE
                     KVKVLLAKALFGKPDVLLLDEPTNGLDIQSITWLEDFLIDFDNTVIVVSHDRHFLNKV
                     CTHMADLDFGKIKLYVGNYDFWKESSELAAKLLADRNAKAEEKIKQLQEFVARFSANA
                     SKSRQATSRKKMLDKIELEEIVPSSRKYPFINFKAEREIGNDLLTVENLTVKIDGETI
                     LDNISFILRPDDKTALIGQNDIQTTALIRAIMGDIDYEGTVKWGVTTSQSYLPKDNSA
                     DFAGGESILDWLRQFASKEEDDNTFLRGFLGRMLFSGDEVNKPVNVLSGGEKVRVMLS
                     KLMLLKSNVLVLDDPTNHLDLESISSLNDGLKNFKESIIFASHDHEFIQTLANHIIVL
                     SKNGVIDRIDETYDEFLENAEVQAKVKELWKD"
     gene            10016..11041
                     /gene="trpS"
                     /locus_tag="VXE25_001341"
     CDS             10016..11041
                     /gene="trpS"
                     /locus_tag="VXE25_001341"
                     /EC_number="6.1.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan--tRNA ligase"
                     /protein_id="HEV0771795.1"
                     /translation="MTKPIILTGDRPTGKLHIGHYVGSLKNRVLLQEEDKYDMFVFLA
                     DQQALTDHAKDPQTIVESIGNVALDYLAVGLDPNKSTIFIQSQIPELAELSMYYMNLV
                     SLARLERNPTVKTEISQKGFGESIPTGFLVYPIAQAADITAFKANYVPVGTDQKPMIE
                     QTREIVRSFNNAYNCDVLVEPEGIYPENERAGRLPGLDGNAKMSKSLNNGIYLADDAD
                     TLRKKVMSMYTDPDHIRVEDPGKIEGNMVFHYLDVFGRPEDAQEIADMKERYQRGGLG
                     DVKTKRYLLEILERELGPIRERRIEFTKDMGEVYNMIQKGSERAREVAGQTLSEVKGA
                     MGLHYFN"
     gene            11193..12671
                     /gene="guaB"
                     /locus_tag="VXE25_001342"
     CDS             11193..12671
                     /gene="guaB"
                     /locus_tag="VXE25_001342"
                     /EC_number="1.1.1.205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000073411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IMP dehydrogenase"
                     /protein_id="HEV0771796.1"
                     /translation="MSNWDTKFLKKGFTFDDVLLIPAESHVLPNDADLTTKLADNLTL
                     NIPIITAAMDTVTESQMAIAIARAGGLGVIHKNMSIAQQADEVRKVKRSENGVIIDPF
                     FLTPEHTIAEADELMGRYRISGVPVVETLENRKLVGILTNRDLRFISDYNQPISNHMT
                     SENLVTAPVGTDLATAESILQEHRIEKLPLVDEEGSLSGLITIKDIEKVIEFPNAAKD
                     EFGRLLVAGAVGVTSDTFERAEALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPDR
                     TLIAGNIATAEGARALYEAGVDVVKVGIGPGSICTTRVIAGVGVPQVTAIYDAAAVAR
                     EYGKTIIADGGIKYSGDIVKALAAGGNAVMLGSMFAGTDEAPGETEIFQGRKFKTYRG
                     MGSIAAMKKGSSDRYFQGSVNEANKLVPEGIEGRVAYKGAAADIVFQMIGGIRSGMGY
                     CGAANLKELHDNAQFIEMSGAGLKESHPHDVQITNEAPNYSM"
     gene            complement(12722..13819)
                     /gene="recF"
                     /locus_tag="VXE25_001343"
     CDS             complement(12722..13819)
                     /gene="recF"
                     /locus_tag="VXE25_001343"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000266665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA replication/repair protein RecF"
                     /protein_id="HEV0771797.1"
                     /translation="MWLQHLSLKTFRNYKETKIDFNPKLNVFLGRNAQGKTNMLEAIY
                     FLALTRSHRTRTDKNLIHFDEEQLHLSGLVQKKTGSIPLEIELTQKGRVTKVNHLKQA
                     RLSDYVGHMNVVLFAPEDLQLIKGAPSIRRKFIDMELGQIKPIYLSDLTNYNHILKQR
                     NTYLKSAQKIDETFLSVLDDQLVDYGCRVMNHRLDFIKKLESFGRKKHFELSNQIEEL
                     SISYQSSVNITDKQNLSESFKIALEKSRSRDLFKKNTGVGPHRDDISFYINGMDASFG
                     SQGQHRSLVLSIKLAEIELMESITTESPILLLDDVMSELDNTRQLKLLETISQSIQTF
                     ITTTSLDHLQNLPENLSIFTIQDGKAAVNRN"
     gene            complement(13822..14190)
                     /locus_tag="VXE25_001344"
     CDS             complement(13822..14190)
                     /locus_tag="VXE25_001344"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding S4 domain-containing protein"
                     /protein_id="HEV0771798.1"
                     /translation="MEYKLFEEFITLQALLKELGITHSGGAIKSFLSEHSVYFNRELE
                     SCRGKKLRIGDKVDIPDMNIDILLTQPTSEEQDEYQADKVEKERIAKLVKKMNKGVKK
                     DKSKPASSPKSQQAPRFPGR"
     gene            14349..15599
                     /locus_tag="VXE25_001345"
     CDS             14349..15599
                     /locus_tag="VXE25_001345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="insulinase family protein"
                     /protein_id="HEV0771799.1"
                     /translation="MELVHGISTHFIQSKKFKTNKITVRFTAPLSLDTIAGHMLSASM
                     LETANQMYPTSQDLRRHLASLYGTDMSTNCFRRGQSHIIELTFTYVRDEFLSRKNVLT
                     SQILELVKETLFSPVVVDNGFDPALFEIEKKQLLASLAADMDDSFYFAHKELDKLFFH
                     DERLQLEYSDLRNRILAETPQSSYSCFQEFLANDRIDFFFLGDFNEVEIQNVLESFGF
                     KGRKGDVKVQYCQPYSNILQEGMVRKNVGQSILELGYHYRSKYGDEQHLPMIVMNGLL
                     GGFAHSKLFTNVRENAGLAYTISSELDLFSEFLRMYAGINRENRNQARKMMNNQLLDL
                     KKGYFTEFELNQTKEMIRWSLLLSQDNQSSLIERAYQNALFGISSADFKGWIAKLEQV
                     DKDAICRAANNVKLQAIYFMEGIE"
     gene            15596..16879
                     /locus_tag="VXE25_001346"
     CDS             15596..16879
                     /locus_tag="VXE25_001346"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="insulinase family protein"
                     /protein_id="HEV0771800.1"
                     /translation="MTKVVFEEKYYPAVKEKVYRTRLANGLTVALLPKKEFKEVYGSV
                     TVQFGSVDTFVTEVDGDVKQYPGGIAHFLEHKLFEREDSSDLMSAFTSLGADSNAFTS
                     FTKTNYLFSATDYFLENLDLLDELVTSAHFTEASILTEQDIIQQEREMYQDDPDSCLF
                     FSTLANLYPGTPLATDIVGSEESISQINLTNLQENFTKFYKPVNMSLFLVGNFDVERV
                     QDYFESKELKDSDFQEVAREKLFLQPVKPTDSMRMEVSSPKLAIGVRGKREVSEADCY
                     RHHILLKLLFAMMFGWTSDRFQKCYESGKIDASLSLEVEVTSRFHFVMLTMDTKEPVA
                     LSHQFRKAIRNFTKDLDITEEHLDIIKREMFGEFFSSMNSLEFIATQYDAFENGETIF
                     DLPKILQEITLEDVLDAGHHLIDDGDIVDFTIFPS"
     gene            16921..17742
                     /locus_tag="VXE25_001347"
     CDS             16921..17742
                     /locus_tag="VXE25_001347"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEV0771801.1"
                     /translation="MRKKTIGEVLRLARINQGLSLDELQKKTEIQLDMLEAMEADDFD
                     QLPSPFYTRSFLKKYAWAVELDDQIVLDAYDSGSMITYEEVDVDEDELTGRRRSSKKK
                     KKKTSFLPLFYFILFALSILIFVTYYVWNYIQTQPEEPSLSNYSVVQSTSSTSSVPHS
                     SSSSSSSIESAISVSGEGNHVEIAYKTSKETVKLQLAVSDVTSWVSVSESELEGGVTL
                     SPKKKSAEATVATKSPVTITLGVVKGVDLTVDNQTVDLSKLTAQTGQITVTFTKN"
     gene            17753..18298
                     /gene="pgsA"
                     /locus_tag="VXE25_001348"
     CDS             17753..18298
                     /gene="pgsA"
                     /locus_tag="VXE25_001348"
                     /EC_number="2.7.8.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000712151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDP-diacylglycerol--glycerol-3-phosphate
                     3-phosphatidyltransferase"
                     /protein_id="HEV0771802.1"
                     /translation="MKKEQIPNLLTIGRILFIPIFIFILTIGNSIESHIVAAIIFAVA
                     SITDYLDGYLARKWNVVSNFGKFADPMADKLLVMSAFIMLIELGMAPAWIVAVIICRE
                     LAVTGLRLLLVETGGTILAAAMPGKIKTFSQMFAIIFLLLHWTLLGQVLLYVALFFTI
                     YSGYDYFKGSAYVFKGTFGSK"
     gene            18295..19122
                     /locus_tag="VXE25_001349"
     CDS             18295..19122
                     /locus_tag="VXE25_001349"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter ATPase"
                     /protein_id="HEV0771803.1"
                     /translation="MKSIIDVKNLSFRYKENQNYYDVKDITFHVKRGEWLSIVGHNGS
                     GKSTTVRLIDGLLEAESGEIVIDGQRLTEENVWNIRRQIGMVFQNPDNQFVGATVEDD
                     VAFGLENQGLSRQEMKKRVEEALALVGMLDFKKREPARLSGGQKQRVAIAGVVALRPA
                     ILILDEATSMLDPEGRRELIGTVKGIRKDYDMTVISITHDLEEVAMSDRVLVMKKGEI
                     ESTSSPGELFSRNDLDQIGLDDPFANQLKKSLSQNGYDLPENYLTESELEDKLWELL"
     gene            19107..19946
                     /locus_tag="VXE25_001350"
     CDS             19107..19946
                     /locus_tag="VXE25_001350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000510406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter ATPase"
                     /protein_id="HEV0771804.1"
                     /translation="MGIALENVNFTYQEGTPLASAALSDVSLTIEDGSYTALIGHTGS
                     GKSTILQLLNGLLVPSQGSVRVFDTLITSTSKNKDIRQIRKQVGLVFQFAENQIFEET
                     VLKDVAFGPQNFGVSEEDAVKTAREKLALVGIDESLFDRSPFELSGGQMRRVAIAGIL
                     AMEPAILVLDEPTAGLDPLGRKELMTLFKKLHQSGMTIVLVTHLMDDVAEYANQVYVM
                     EKGRLVKGGKPSDVFQDVVFMEEVQLGVPKITAFCKRLADRGVSFKRLPIKIEEFKES
                     LNG"
     gene            19939..20733
                     /locus_tag="VXE25_001351"
     CDS             19939..20733
                     /locus_tag="VXE25_001351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000377903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     protein EcfT"
                     /protein_id="HEV0771805.1"
                     /translation="MDSMILGRYIPGDSIVHRLDPRSKLLAMMLLILIVFWANNPLTN
                     LILFIATGIFIALSGVSLSFFIQGLKSMFFLIAFTTIFQLFFISNGNVLFEFSFVRIT
                     DYALQQAGIIFCRFVLIIFFSTLLTLTTMPLSLASAVEALLAPLKRVKVPVHEIGLML
                     SMSLRFVPTLMDDTTRIMNAQKARGVDFGEGSIVQKVKAMIPILIPLFATSLKRADSL
                     AIAMEARGYQGGKGRSQYRQLKWTLKDTLTILVILVLGCCLFFLKS"
     gene            20792..21610
                     /gene="mreC"
                     /locus_tag="VXE25_001352"
     CDS             20792..21610
                     /gene="mreC"
                     /locus_tag="VXE25_001352"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001078980.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein MreC"
                     /protein_id="HEV0771806.1"
                     /translation="MNRFKKSKYVIIVFVTVLLVSALLATTYSSTIVTKLGDGISLVD
                     RVVQKPFQWFDSVKSDLAHLTRTYNENESLKKQLYQLEVKSNEVESLKTENEQLRQLL
                     DMKSKLQATKTLAADVIMRSPVSWKQELTLDAGRSKGASENMLAIANGGLIGSVSKVE
                     ENSTIVNLLTNTENADKISVKIQHGSTTIYGIIIGYDKENDVLKISQLNSNSDISAGD
                     KVTTGGLGNFNVADIPVGEVVATTHSTDYLTREVTVKLSADTHNVDVIELVGNS"
     gene            21610..22104
                     /gene="mreD"
                     /locus_tag="VXE25_001353"
     CDS             21610..22104
                     /gene="mreD"
                     /locus_tag="VXE25_001353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001249461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein MreD"
                     /protein_id="HEV0771807.1"
                     /translation="MRQLKRVGVFLLLPFFVLIDAHISQLLGSFFPHVHLASHFLFLF
                     LLFETIEVSEYLYLVYCFVIGLVYDVYFFHLIGITTLLFILLGAFLHKLNSVILLNRW
                     TRMLAMIVLTFLFEMGSYLLAFMVGLTVDSMSIFIVYSLVPTMILNFLWITVFQFIFE
                     KYYL"
     gene            22198..23376
                     /locus_tag="VXE25_001354"
     CDS             22198..23376
                     /locus_tag="VXE25_001354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000727004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CHAP domain-containing protein"
                     /protein_id="HEV0771808.1"
                     /translation="MKKKILASLLLSTVMVSQVAVLTTAHAETTDDKIAAQDNKISNL
                     TAQQQEAQKQVDQIQEQVSAIQAEQSNLQAENDRLQAESKKLEGEITELSKNIVSRNQ
                     SLEKQARSAQTNGAVTSYINTIVNSKSITEAISRVAAMSEIVSANNKMLEQQKADKKA
                     ISEKQVANNDAINTVIANQQKLADDAQALTTKQAELKAAELSLAAEKATAEGEKASLL
                     EQKAAAEAEARAAAVAEAAYKEKRASQQQSVLASANTNLTAQVQAVSESAAAPVRAKV
                     RPTYSTNASSYPIGECTWGVKTLAPWAGDYWGNGAQWATSAAAAGFRTGSTPQVGAIA
                     CWNDGGYGHVAVVTAVESTTRIQVSESNYAGNRTIGNHRGWFNPTTTSEGFVTYIYAD
                     "
     gene            23600..24379
                     /gene="rpsB"
                     /locus_tag="VXE25_001355"
     CDS             23600..24379
                     /gene="rpsB"
                     /locus_tag="VXE25_001355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000268478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S2"
                     /protein_id="HEV0771809.1"
                     /translation="MAVISMKQLLEAGVHFGHQTRRWNPKMAKYIFTERNGIHVIDLQ
                     QTVKYADQAYDFMRDAAANDAVVLFVGTKKQAADAVAEEAVRSGQYFINHRWLGGTLT
                     NWGTIQKRIARLKEIKRMEEDGTFEVLPKKEVALLNKQRARLEKFLGGIEDMPRIPDV
                     MYVVDPHKEQIAVKEAKKLGIPVVAMVDTNTDPDDIDVIIPANDDAIRAVKLITAKLA
                     DAIIEGRQGEDAVAVEAEFAASETQADSIEEIVEVVEGDNA"
     gene            24458..25498
                     /locus_tag="VXE25_001356"
     CDS             24458..25498
                     /locus_tag="VXE25_001356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003053075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Ts"
                     /protein_id="HEV0771810.1"
                     /translation="MAEITAKLVKELREKSGAGVMDAKKALVETDGDIEKAIELLREK
                     GMAKAAKKADRVAAEGLTGVYVNGNVAAVIEVNAETDFVAKNAQFVELVNTTAKVIAE
                     GKPANNEEALALIMPSGETLEAAYVSATATIGEKISFRRFALIEKTDAQHFGAYQHNG
                     GRIGVISVVEDGDEALAKQLSMHIAAMKPTVLSYKELDEQFVKDELAQLNHVIDQDNE
                     SRAMVNKPALPHLKYGSKAQLTDDVIAQAEADIKAELAAEGKPEKIWDKIIPGKMDRF
                     MLDNTKVDQAYTLLAQVYIMDDSKTVEAYLESVNASVVEFARFEVGEGIEKAANDFEA
                     EVAATMAAALNN"
BASE COUNT         8242 a         4009 c         5196 g         8171 t
ORIGIN      
        1 attaaagttg taacagttgg gaaactgaaa gaaaagtatt taaaagatgg tatcgcagag
       61 tattcaaaac gaatttctag atttgctaag tttgaaatga ttgagttatc agatgaaaaa
      121 acaccagata aggccagtga atcagaaaat caaaagattt tagaaataga aggtcagaga
      181 attttatcaa aaattgctga ccgtgatttc gttattgtgt tagccattga agggaaaact
      241 ttcttctcag aagaatttag taagcagtta gaagaaactt ctataaaagg attttctact
      301 cttactttta ttattggggg aagtttagga ttgtcatcat ctgtaaaaaa tagagccaat
      361 ctttctgtca gttttggtcg cctaacctta ccccatcagt taatgagact agttcttgtt
      421 gaacaaatct atcgcgcttt tacgattcag cagggattcc cctaccataa atagaaaatt
      481 gacttttaat tgaatttttg gtagaataat tgtattaggt ctcatagctc agctggatag
      541 agcattcgcc ttctaagcga acggtcgcag gttcgaatcc tgctgggatc aatataatag
      601 caaagctggg aattttcccg gcttttttct taaaaaagta cactttggga gaaaaaaatg
      661 acagttgaga gaattttatc taaaacgaaa ttccattttg tataatggtt tttgtaagtt
      721 agcttacaag aaaaaacatt ttaggagatt ttattatgaa aaacacagtt aaattggaac
      781 agtttgtagc tttgaaggaa aaagacttac aaaagattaa aggtggggag atgaggttgt
      841 caaaattctt ccgtgatttt attttacaaa gaaaaaagta atgaaataag gggaaagagt
      901 aatggattta tttggatttg ggacggttat tgttcatttt ttaattatta gtcacagtta
      961 ccattttatt tgtaaaggtc aaataaatag aaaagaatta ttcgtttttg gtgcttatac
     1021 attactaaca gaaatagtat ttgattttcc cttatatatt ctatatttag atgggttagg
     1081 gattgaaaga tttttatttc ctttgggatt atattcctat tttcgatgga tgaaacagta
     1141 tgagagggat agaggactat tcctaagttt actactatct cttttatatg agagcactca
     1201 taactttctg tccgtaactt tctcctctat aacaggagat aattttgttt tacaatatca
     1261 tttcccattc tttttcgttg tgacggtgtt aacctatttt gttacattaa aaatcattta
     1321 ctatttccat ttggaactag cctattttga cgaggactac ctttatcctt tcttgaaaaa
     1381 agtatttttt gctttactat tgctacatat tgtatctttc gtttcagata tggtaagtac
     1441 gattaaacat ttgaatagtt ttggaagtat tttgtcatct attgtcttta tctctctcct
     1501 tttgaccttc tttgcaatga attctcataa agttcaaatg gagaaagaga ttgctttgaa
     1561 gcagaagaaa tttgaacaga aacatttaca gaattacaca gatgaaattg ttggtctgta
     1621 taatgaaatc cgtggttttc gacatgatta tgctggaatg cttgtcagca tgcagatggc
     1681 aattgacagt ggtaatttac aggaaattga cagaatttac aatgaagttt tagtcaaagc
     1741 aaatcataaa ttgcgttcag ataagtacac ttactttgat ttgaacaaca tagaagactc
     1801 agctttacga agtttggttg ctcagtcaat tgtctatgct cgaaataatg gtgtagagtt
     1861 tacactggaa gtaaaagata cgattaccaa gcttccaatt gaactattgg atttggttcg
     1921 tatcatgagc gttttattga ataatgctgt cgaaggatcg gctgatagct ataaaaagca
     1981 gatggaagta gcagttatta agatggaaac tgaaacagtt attgtgattc agaattcatg
     2041 taaaatgacg atgactcctt caggagatct atttgcctta ggattctcca ctaagggaag
     2101 aaatcgcgga gtcggattaa ataatgtgaa agaactacta gataagtaca acaatattat
     2161 tttagaaaca gagatggaag gcagtacatt tagacaaatc attagattta agagggaatt
     2221 tgaatgaaag ttttaatttt agaagatgtt attgaacatc aagtgagact agagagaata
     2281 ttggatgaaa tttcgaaaga atcgaatatt ccaatatcat acaagacaac gggaaaagtc
     2341 cgtgaatttg aagaatacat tgaaaatgat gaagtaaatc agctttattt cctagatatc
     2401 gatattcatg gaattgagaa aaagggattt gaagtggctc agctcattcg tcattacaat
     2461 ccttacgcta ttatcgtctt tatcactagt cgatcagagt ttgcgactct aacctataaa
     2521 taccaggtat cagccctaga ttttgttgat aaggatatca atgatgagat gtttaagaag
     2581 agaattgagc aaaatatctt ctacacgaag agtatgttac ttgaaaatga agatgttgta
     2641 gattatttcg actacaatta caaaggaaat gatttaaaaa ttccttacca tgatattttg
     2701 tatattgaaa caacaggggt ctctcataaa ttgcgcatta ttggtaagaa ttttgcaaaa
     2761 gagttttatg gtaccatgac agatattcag gaaaaggaca aacatactca gcgattttat
     2821 tctcctcaca agtcattttt ggtaaatata ggcaatatca gagaaattga tcgaaaaaac
     2881 ttagaaattg ttttctatga agaccatcgt tgtcctattt caagattaaa aattagaaaa
     2941 ttaaaagata ttttagagaa aaaatctcaa aagtgattga caattagcaa gaaattgata
     3001 taatggttat atctgctaca gatagaaggt ccgttggtca aggggttaag acaccgcctt
     3061 ttcacggcgg taacacgggt tcgaatcccg tacggactat tttatccgcc atagctcagt
     3121 tggtagtagc gcatgactgt taatcatgat gtcgtaggtt cgagtcctac tggcggagta
     3181 tagataaaag ggaacacagc tgtgttcctc tttttgtatc aatttgtatc accaagcatt
     3241 ttcataagga agtctgttat ttcttgagaa ctttcttttt ttccatgtgc aatccaagtt
     3301 tggcagacac caaaaagtgc atgagttaga tagatgctac tatattctaa ttcggtggta
     3361 tttagattca gttgcataaa tcgcttttgt aaatctgtac taagcatgat atgaagttta
     3421 tttcgtaaga aattttggat ttctttagtc ccattttcag aaagaagggc agccagaagt
     3481 ggttctgact ctagatattc aaaaacttct aaaatagcgt ctcttttgtg atgagcatgt
     3541 ttttgaaaaa tatattcaaa tgtatggaat agcttgcttt gatagtgctc aatcatatca
     3601 tacttatcct tatagtgagt atagaagctg gaacgactaa ttccggcttt ttctactaat
     3661 ttgacagtag aaattttatc aaatggctgt tccatcagta attgtaccat agcattttca
     3721 atagttcgct ttgtttttaa gcgtttgtta ctttcttgca tatttcctcc ttgtaaacaa
     3781 attagactat atgtctaaaa atagattttt tatcttgtaa tttagatttt ttaatgtata
     3841 atctattata tcaaaatttt agacaatatg tttaaaaaag gagaaactaa gtttaaagaa
     3901 tggaaagcaa tttaaaaaaa accaaccttt attattgtca tgatcgggat ttctcttatt
     3961 ccagatctgt acaatatcat atttttgtca tcaatgtggg atccatatgg gcaattgtct
     4021 gacttacctg tggcagttgt aaataatgat aaagaggctt cctataatgg taatactatg
     4081 gcaataggaa aagacatggt gtccaattta aaagaaaata aaaccttgga ttttcatttt
     4141 gtagatgaag aggaaggaaa gaagggattg gaagatggcg attactatat ggtagtgact
     4201 ttaccaagtg atttatctga aaaaacaact acattatcca atattcaatc gacagcagct
     4261 tatcaatcat tgacaagtga gcaacaaact gagataagtg attctgtatc tcaaaattca
     4321 actgatagta ttcaatcggc tcagtcaatt gtagctttag tacaagattt acagggaagt
     4381 ttagaaaact tacaaaatca atcttctaat ctttcgactt taaaaaatca atctaatcaa
     4441 gtatcaccta ttacttctac ttctttgata ggattgtcaa gtggattaac agagatacaa
     4501 ggagatgtta ctagcaaatt agttcctgcc agtcagtcga ttgcatcagg tgtaaacgca
     4561 tatactacag gtgttgataa agtttctcag ggcgcaagtc aactaagtga aaaaaaatgc
     4621 caccttgaca ggtagtttga ataaactagt ttcaggctca aacaccttga cacaaaaatc
     4681 ttctagattg acagcaggag ttggttaatt acaatcagga tctgggtaat tagcagacaa
     4741 atccagtcag ttactttcag gtgcttctcc attagagaat agagctaata aattggcaga
     4801 tggatctggg aaactagcag aaggtggaac aaagttaact tctggattgg aagatttaca
     4861 gacaggactt gcttctttag gacaaggact aggtaatgct agtgatcaac tcaaatcagt
     4921 atcaacagaa tctaaaaatg cagagatttt gtcaaatcca ctcaatcttt caaaaacaga
     4981 caatgatcaa gttcttgtaa atggaatcgc aatagctcct tatatgatat cagttgctct
     5041 ttttgttgca gcaatatcaa caaatatgat atttgcgaaa ttgccttcag gacgtcatcc
     5101 agagagccgt tgggcttggt tgaaatctcg agctgaaata aatggtatta tagctgtttt
     5161 ggcaggaatt ttggtatatg gaggagttca gcttattggt ttaactgcta atcatgagat
     5221 gagaatattt attctcatca tcctaacaag tttagtattc atgtctatgg tgaccacttt
     5281 aacaacgtgg aatagccgta taggagcttt tttctcactt attttgcttt tactacagtt
     5341 agcatcaagt gcaggtactt atccacttgc tttgacaaat gatttcttta gatctattaa
     5401 tccctggtta ccaatgagct attcagtttc gggattacga caaacaatct ccatcaacaa
     5461 gtcattttcc tagctgtcat actagctcta tttactggtt taggtatgct agcctatcaa
     5521 cataagaaaa tagaagaaga ttaaaaaaat cgaccgatta actggtcgat tttttatgcc
     5581 ttagatgact ttcgtctgtg attatagatt ccaaatagta agagagaagt aaaggaacag
     5641 attgctccag taataaaacc attgggaatg aaggaaagtg taatagttcc tttccccttg
     5701 ggaatgtcaa ctttcataaa tccagtttga gcttgtttaa tttctatttt cttaccatct
     5761 tggtaggcag accaaccttt gtcataagga atggtgaaga aaatagatgt atcttgttgg
     5821 acatcatatg tagcaaaaac cttgttttta gaagttgata ctgtgacagg ttgttcttta
     5881 attttttgaa ttgcctcggt gaaagttttg gtatctaaac gatagaaggt aggagattca
     5941 aatgatactt gtgaatttcc agggaaacta acattgatat tgaaagtttt tttctcttta
     6001 gtatatccta gattaaagaa ggagaagaca ttatcagttg taaaagtctt tttttcacca
     6061 tttacaagga tgtcaacctt cttttgttta tcgttagaaa agtgaaggtt tatgaaagag
     6121 agataaactt ggctgttttc tggaacttca atttgatact ggattgctgc atcttcattt
     6181 gaagaacttg tgacactaat caaatcatta gtattttcta ttttttctgt tttttcataa
     6241 ggtattggag aaaaataatc aaaattgacg ttagcaagtt gatttaaaaa tgaggcctga
     6301 ttatccaagg tatgttcatt gaacttgaca tcattgtaaa cagattgact agcaactgca
     6361 atcggaagag agtattgatt ttcatatagg gtaagattat ctttttgata gatatcttta
     6421 aagccatact tatcaatagg actgtctgag atattgtact ggataccaaa taaactatca
     6481 gccaaaatac tattatttgc atatcggaga ttgagattag tcccagagga tttaaaacca
     6541 agtttatcta aagtagagct tgatgaacga tttcgaacag atgaaaattg agagattcca
     6601 ttgtagttga atttcatact gtcatttcct gtctgagttt gtagtttttc agtacgagta
     6661 aattgatttc caatatatgt tgagaaagat tccatagctg ggatatctcg actataagca
     6721 cttcgagaag caaatcccca ttccttagca attccgtcca tttgagatga agcatttaaa
     6781 ctcatttcaa ccagtataaa taaagagatt agaatggcaa atagattcac agatataaac
     6841 tttttgataa ctgcaaggag taaaagagaa tagacaacca aaaattcaag agtaagcaga
     6901 atattcaaat ctgttaaaaa agaataatgc gattttagat agatggtagc taaaaatcct
     6961 gttactacaa gaaaaagcga aactaaaaaa ttccagactt taagttcttt cagacgcttt
     7021 aagacttctg ctgctgtgta aattaacaag gtagagaaaa tccaagcata gcgatgtaaa
     7081 aacatgtttg gagtatgcat gccttgccaa aataagtcaa gagcttctat gtaaaagctt
     7141 gcaattagaa atgcaaagaa tattatatat atgagtttca cgtgaaacct aatagatttc
     7201 agcgtaaaaa ataaaatggt caaaataaag ggaagtagtc caacaaaaat cattgggatg
     7261 gccccatact ttgttgtgtc aaaggaacca atgaattgct tagcaaagag atcaagatac
     7321 cagctacttt cagtttgaaa ctttgtaact tcagtcaatt tttccccatg tgtctgtaaa
     7381 tcaaacagag tgggaagagt cataatcaaa ctagccatac cagctaaaaa ggagataact
     7441 atgaaatcaa gaacagatga ttttcgagtc ttaaagtccc acgaaatttg acagagatac
     7501 cagaaaataa gaaacaatac tgtcatatat ccaaaataat aattttgaat aaataagatt
     7561 gacagacttg taaagtacaa taggagtttc ttttcagtta tcagtagatg taaaccagtt
     7621 ataattaaag gaatcaagat aaaaacatct agccaggttt ttatctctaa ttgactgaca
     7681 gtgaaaccca tcagagcata ggaagtagat aaggctagtt ttaaagtctg agggatagat
     7741 tgaaacaatt tattcaaact aaaaaaggtt gacagaccaa tcaatccaaa ttttaagaga
     7801 gtggtcagat agacagcatc tggcatattc gttagatcaa aaaagtaaac tagaggcgcg
     7861 agaaaactac ccaagtaata actagatagg gcatagaagt ttagccctag accacttgta
     7921 aaggtgtaaa acagactact atttccatgt aggatatttc gtaaggctac atcaaaaata
     7981 acgtattgat gaaagccatc tcctaataga ggagagttgt cgctattcca gtagatacct
     8041 tgagatagat atactccaga cataatcact acaggaatga tgaaagaaat aaaataggtt
     8101 cgatatgttt ttaaaaatga tttcatgtta cctcgtagaa tgatagaaaa ctcagttggt
     8161 taacccaact gagttttgaa gttttattta gtctttccaa agttctttaa cttttgcttg
     8221 tacttctgca ttttctagga attcatcgta ggtttcatcg atacggtcaa tgacgccatt
     8281 tttagataag acaatgatat ggttagccaa agtttgaata aattcgtggt catgactagc
     8341 aaagatgatt gattctttaa agtttttcaa tccatcattc aagcttgaga tagattccaa
     8401 gtccaagtga tttgttggat catcaagtac aaggacattt gattttaaga gcatgagttt
     8461 tgaaagcatg acacgaactt tttctccccc tgacaagaca tttacaggtt tgttaacttc
     8521 atctccagag aagagcatac ggccgaggaa accacgtagg aaagtattgt catcttcttc
     8581 tttacttgcg aattgacgca accagtcaag aattgattct cctcctgcaa aatcagctga
     8641 gttatctttt ggtaggtaag attgactagt tgtaactccc cacttgacag ttccttcata
     8701 gtcaatatct cccatgattg cacgaattaa tgcagtcgtt tgaatatcat tttgtccaat
     8761 aagtgctgtc ttatcatctg gacgcaagat gaaactaata ttatccaaga tagtttcacc
     8821 atcaatcttt acagttagat tttctactgt caagagatca ttaccaatct cacgttccgc
     8881 tttaaagttg ataaatggat atttacgact agatggtaca atctcttcta gctcaatctt
     8941 atcaagcatt ttcttacgtg atgttgcctg ccttgactta gaagcattgg cagagaaacg
     9001 agcaacgaat tcttgcaatt gtttaatttt ttcttctgct ttagcattac ggtctgctag
     9061 caatttagca gcaagctcag aagattcctt ccagaagtcg tagtttccga catagagttt
     9121 gatttttcca aagtcaaggt cggccatgtg agtacaaact ttgtttaaga agtgacggtc
     9181 gtgggatact acgataactg tgttatcaaa gtcaattaag aagtcttcta accaagtaat
     9241 cgattggata tccaaaccgt tagtaggctc gtccaagaga agaacatctg gtttaccaaa
     9301 aagtgctttg gcgaggagaa cctttacttt ttcaccgttg gccaattcgc tcatgttttg
     9361 gtagtgtaat tcttctggaa tgtttaggtt ttgaagtagt tgagaggctt cactctctgc
     9421 ttcccaacct ccaagttcgg caaactctcc ttcgagttcg gcagcacgaa ccccgtcctc
     9481 gtctgagaaa tcttccttca tgtagatagc atctttctct ttcatgatgc tataaagttt
     9541 ttcatttccc atgataacga catcaatggc acgttcatct tcgtagtcaa agtgattttg
     9601 acgaagaaca gagagacgtt catctggacc aagagagatg tgaccagtag taggttcgat
     9661 atctccagct aaaattttta aaaaggttga ttttccggca ccattagcac cgattaatcc
     9721 gtaagtattt ccttctgtaa atttgatatt gacatcatca aaaagtttgc gatcactaaa
     9781 acgtagtgaa acatcagata ctgtaagcaa tatttttctc ctatatgtgt aatatattta
     9841 ttctactaga aaatacagaa atattcaaat ttttatttat caattttgtg taaattatat
     9901 ttacagtatc ctttacacaa atctgtaaaa agcaaggctg atttattttg ataaattacg
     9961 gttatttcat taaaaaaatg ctataattga aaggactata tcgaaggaga acaaaatgac
    10021 taaacccatt attttaacag gagaccgtcc aacaggaaaa ttgcatattg gacattatgt
    10081 tggaagtctc aaaaatcgag tattattaca ggaagaggat aagtatgata tgtttgtgtt
    10141 cttggctgac caacaagcct tgacagatca tgccaaagat cctcaaacca ttgtagagtc
    10201 tatcggaaat gtggctttgg attatcttgc agttggattg gatccaaata agtcaactat
    10261 ttttattcaa agccagattc cagagttggc tgagttgtct atgtattata tgaatctagt
    10321 ttcgttagca cgtttggagc gaaatccaac agtcaagaca gagatttctc agaaaggatt
    10381 tggagaaagc attccgacag gattcttggt ctatccaatc gctcaagcag ctgatatcac
    10441 agctttcaag gctaattatg ttcctgttgg gacagatcag aaaccaatga ttgagcaaac
    10501 tcgtgaaatt gttcgttctt ttaacaatgc atataactgt gatgtcttgg tagagccgga
    10561 aggtatttat ccagaaaatg agagagcagg gcgtttgcct ggtttagatg gaaatgctaa
    10621 aatgtctaaa tcactaaata atggtattta tttagctgat gatgcggata ctttgcgtaa
    10681 aaaagtaatg agtatgtata cagatccaga tcatatccgc gttgaggatc caggtaagat
    10741 tgagggaaat atggttttcc attatctaga tgtttttggt cgtccagaag atgctcaaga
    10801 aattgctgat atgaaagaac gttatcaacg aggtggtctt ggtgatgtga agaccaagcg
    10861 ttatctactt gaaatattag aacgtgaact gggtcctatt cgtgagcgcc gtattgaatt
    10921 tactaaggat atgggagaag tttataatat gattcaaaaa ggtagtgaaa gagcgcgtga
    10981 agttgcgggt caaaccctat ctgaggtaaa aggggcaatg ggacttcatt actttaacta
    11041 agtttatttt acaagaaact atcttttcta tctcgaagaa aagatagttt tttatttacc
    11101 cctgtaacat ttgacaaatt tttatagaat ggtatgatag atacaatata aaaagagtca
    11161 agctcaaaaa gaaagaaaag aggaaacttc gaatgtctaa ttgggacact aaatttttga
    11221 aaaaaggttt tacctttgat gatgtattgc ttattccagc tgaaagtcat gtgttgccta
    11281 acgatgcaga tttaacaact aaattggcag ataatttgac tttaaatatc ccaattatta
    11341 ccgctgccat ggacacagtt acagagagtc aaatggccat tgctattgct cgtgcaggcg
    11401 gtctcggagt tatccataaa aacatgtcaa ttgctcaaca agcagacgag gttcgtaagg
    11461 taaaacgttc tgaaaatgga gttattattg atccgttctt cttgacgcct gaacatacaa
    11521 ttgctgaagc agatgagctt atgggtcgtt accgcatcag tggtgttcca gttgttgaaa
    11581 cacttgaaaa tcgtaaattg gttggtattt tgacaaaccg agatcttcgt tttatttcag
    11641 attataatca accaatttca aaccatatga ctagtgaaaa tcttgttact gctcctgtgg
    11701 gtacggatct tgcaacggct gagagtattc ttcaagagca tcgtattgaa aaacttccgt
    11761 tggtcgatga agaaggcagt ctttctggtt tgatcactat caaagatatt gaaaaagtta
    11821 ttgagtttcc aaatgcggct aaagatgagt ttggtcgtct tctagttgca ggtgcagtag
    11881 gtgttacttc agatacattt gaacgtgcag aggctctttt tgaggcagga gcggatgcga
    11941 ttgttattga tactgcacat ggtcattctg caggtgtctt gcgtaaaatt gccgagattc
    12001 gtgctcattt cccagatcgg actttgattg ctggaaatat tgctactgct gaaggtgcac
    12061 gtgcccttta tgaagcgggt gtagacgttg ttaaggttgg tattggacca ggttctatct
    12121 gtactactcg tgtgattgct ggtgttggtg ttccgcaagt aacagctatc tacgatgctg
    12181 cagctgttgc gcgcgaatat ggtaaaacga ttattgctga cggtgggatc aagtattctg
    12241 gagatattgt aaaagcactt gctgcaggtg gaaatgctgt tatgcttgga tctatgtttg
    12301 ctggaactga tgaagctcca ggcgaaactg aaatcttcca aggacgtaaa ttcaagactt
    12361 accgtggtat gggatcaatt gctgctatga agaaaggttc aagcgaccgt tatttccaag
    12421 gttctgtcaa tgaagcaaac aagcttgttc cagaaggaat tgaaggtcgt gttgcttata
    12481 aaggagcggc agctgatatt gttttccaaa tgattggtgg tattcgctct ggtatgggtt
    12541 actgtggtgc agctaacctt aaagaactac acgataatgc tcaatttatt gaaatgtctg
    12601 gtgctggttt gaaagaaagc catcctcatg atgtgcaaat tactaatgag gcaccaaatt
    12661 attctatgta aaaaacaatg aaaagaactc cagtgaaaac aggagttctt ttacaatgtt
    12721 gtcaatttct atttacagca gctttaccat cctgaatagt gaagatactt agattttctg
    12781 gcagattttg aagatggtct aagcttgttg ttgtgataaa ggtttggatt gattgagaaa
    12841 tcgtttctaa taattttaac tgtctagtgt tgtcaagttc actcatcaca tcgtcaagca
    12901 gtaatatcgg agattctgtg gtaatgcttt ccattaattc gatttctgct aattttatcg
    12961 agaggacgag actacgatgt tgaccttggc ttccgaaact agcatccatc ccatttatat
    13021 aaaaagaaat gtcatctcga tgaggaccga caccagtatt ctttttaaat aaatctctgg
    13081 atctactttt ttctaaagca attttgaaag attcggataa gttttgtttg tcagttatat
    13141 tgacagaaga ttgataggat attgacaact cttcgatctg attagagagt tcaaaatgtt
    13201 tcttacgccc aaatgattct agttttttta tgaaatctaa gcggtgattc attacacgac
    13261 atccataatc aactagctga tcatctaaca cagaaaggaa tgtttcatct attttttgag
    13321 ctgattttag gtaagtgttt ctttgcttta ggatgtggtt ataattggtt aagtcagata
    13381 aatagattgg cttaatttgc ccaagttcca tatcaatgaa ttttcgtcga atcgaaggtg
    13441 ctcctttaat tagttgtaaa tcttcaggag caaataagac aacattcatg tgtcctacat
    13501 aatctgaaag gcgtgcctgt tttaagtgat taacttttgt tacacggcct ttttgtgtta
    13561 gttcgatttc taggggaatg gatccagttt ttttctgaac gagacctgaa agatgaagtt
    13621 gttcctcatc aaaatgaatg agatttttat ctgttcgagt tcgatgacta cgcgttaagg
    13681 ctaaaaaata gatagcctct aacatgtttg tttttccttg tgcattacgt cccaaaaaga
    13741 cattcaattt aggattaaag tctattttcg tttctttgta attacgaaaa gtcttgagag
    13801 atagatgttg tagccacatg attatctacc agggaatcgt ggagcttgtt ggcttttagg
    13861 tgatgaagca ggtttcgatt tgtctttttt aactccctta ttcatctttt tgacaagttt
    13921 agcgatccgt tctttttcaa ctttatcagc ttggtattca tcttgttctt cagaagtagg
    13981 ttgtgtcaac aagatgtcaa tgttcatgtc agggatgtca actttatcgc caatacgaag
    14041 tttttttcca cgacaactct ctaattccct attaaagtaa acagaatgtt cagagagaaa
    14101 tgatttaata gctcctccgc tatgtgtaat tccaagttct ttgagtagtg cttggagggt
    14161 aataaattct tcaaataatt tgtattccat aattcacctc aatctttggt attataccat
    14221 attttcctaa aaatagtgag agagacagcg agaaatgtaa gcgattttta tttcaaaagt
    14281 gttacaggga acaagaaaat ttcaggtttt cgtgatataa tagaagtctg tatataagga
    14341 ggtaaatcat ggagttagtg catggaattt caacacattt tatccaatca aaaaagttta
    14401 aaacaaacaa aattaccgtg cgttttaccg ctccattatc ccttgatacg attgcaggtc
    14461 acatgttgag tgcaagtatg ctagagactg ctaatcagat gtaccccact tctcaagatt
    14521 tgaggagaca cttggccagt ctatacggta cagatatgtc aaccaattgt ttcagaagag
    14581 ggcaaagcca cattatagaa ttgacattta cctatgttcg tgatgagttt ttaagtagga
    14641 aaaacgtgct aacctctcag attttggaac ttgtaaaaga aactcttttt tcacccgtag
    14701 tagttgataa tgggtttgat ccggccttat ttgaaattga gaaaaaacaa ttgctagcaa
    14761 gtttagcagc tgatatggat gattcttttt attttgcaca taaagaattg gataaattgt
    14821 tttttcatga tgaacgtctt caattggaat atagtgattt acgaaatcgt attttagctg
    14881 aaactccaca aagttcttat tcttgtttcc aagaattttt agccaatgat cgaatagatt
    14941 tctttttcct aggtgatttt aatgaggttg aaattcaaaa tgtattagaa tcatttggct
    15001 ttaaaggtcg aaaaggagat gtgaaggttc agtattgtca accttattct aatatccttc
    15061 aggaaggtat ggttcggaaa aatgtgggac aatccatttt ggaattaggt tatcattacc
    15121 gttctaaata tggtgatgag caacatttac ccatgattgt aatgaatggt ttacttggtg
    15181 gatttgctca ctctaagctc tttacaaatg tccgtgaaaa tgctggatta gcttatacca
    15241 tttcaagtga gcttgattta tttagtgaat tcttgaggat gtatgctggt atcaatcgag
    15301 aaaatcgtaa ccaggctcgt aaaatgatga ataatcaact gcttgattta aaaaaaggtt
    15361 attttacaga gtttgagtta aatcagacca aggaaatgat tcgttggtcg ttgttacttt
    15421 ctcaagataa tcaatcttca ttgattgaac gtgcttatca aaatgcctta tttggaatat
    15481 cttcagcaga ctttaaaggt tggattgcaa aactcgagca agttgacaaa gatgctattt
    15541 gtagagcagc taataatgtg aaactacaag cgatttactt tatggaagga atagaatgac
    15601 aaaggttgtt tttgaagaaa aatactatcc agctgtaaaa gaaaaggttt atcgaactcg
    15661 tttggccaat ggattgacag ttgctctttt gcctaaaaag gaatttaaag aggtttacgg
    15721 gagtgtcact gtacagtttg gttcggtaga tacgtttgtc acagaagttg acggagatgt
    15781 aaaacaatat cctggaggaa ttgctcattt tcttgaacat aaattatttg agagagaaga
    15841 ttctagtgat ttgatgtcgg cttttacgag tctaggtgca gatagtaatg cctttacaag
    15901 ctttacaaaa acaaactatc ttttttcagc aacggattat tttttagaaa atttagattt
    15961 acttgatgaa ttggtaacat cagcacactt tactgaagct tccattctga cagagcagga
    16021 tattattcag caagaacgag aaatgtacca agatgatcca gattcgtgtt tattcttttc
    16081 aactttagcg aatttgtatc ctggtacacc tttagcaact gatatagttg gaagtgagga
    16141 gtccatttcc caaatcaatc taactaattt gcaagaaaat tttacaaagt tttacaaacc
    16201 tgtaaacatg tctctgtttt tagttggtaa ttttgatgtg gagcgagtac aggactattt
    16261 tgaaagcaaa gaactgaaag attcagattt tcaggaagta gcaagagaaa agttgttttt
    16321 acagcctgta aagccaacag atagtatgag aatggaagta tcttctccca aactagcgat
    16381 tggagttaga ggtaagcgag aagtttctga agcggattgc tatcgacatc atattttatt
    16441 aaaattattg tttgcaatga tgtttggttg gacttcggat cgttttcaaa aatgttatga
    16501 atcaggtaaa attgatgcat ccttatctct ggaagttgaa gtaacaagtc gctttcattt
    16561 tgtcatgttg acaatggata cgaaagagcc agttgctttg tctcatcaat ttaggaaggc
    16621 tattcgtaat tttacaaagg atttagatat tacagaggaa catttagata ttatcaaaag
    16681 agagatgttt ggcgaatttt tcagtagcat gaactctctt gaatttattg caacgcaata
    16741 tgatgctttt gaaaatggtg agacaatttt tgatttgccg aaaattttac aggaaattac
    16801 tttagaggat gtccttgatg ctggacatca tttaatagat gatggtgaca tagttgattt
    16861 tacaatattc ccatcgtagt aacctattat aatagacact agaaagaagg gatgacaagt
    16921 atgagaaaaa aaacaattgg agaggtttta cgattagcta gaatcaatca gggattgagt
    16981 ttagatgaat tgcagaaaaa gacagaaatc cagttagata tgttggaagc aatggaagca
    17041 gacgatttcg atcaacttcc aagtcctttt tacacgcgtt ctttcttgaa aaaatatgca
    17101 tgggctgttg agttagatga ccaaattgtt ttggatgctt atgattctgg gagtatgatt
    17161 acttatgagg aagtagatgt tgatgaagat gagttgacag gtcgtagacg ttcaagtaag
    17221 aaaaagaaga aaaaaacatc atttttacct ttattttatt ttatcctttt tgctttatcg
    17281 attttaattt ttgtgactta ttatgtttgg aactatattc aaactcaacc agaggagcct
    17341 tctctttcta attacagtgt ggttcaatca acaagttcaa ctagctctgt tccccactcc
    17401 tcaagtagta gttcttctag tatagaatca gctataagtg tatcaggcga aggaaatcat
    17461 gtagaaatcg cttataagac aagtaaggaa acagttaaat tgcaattggc agtttcagat
    17521 gttacaagtt gggtcagtgt ttcagaaagc gaacttgagg gcggtgtaac cttatcgcca
    17581 aagaagaaaa gtgcagaagc aacagttgca actaaaagtc ctgtaacaat tacgttaggt
    17641 gttgtaaaag gtgttgattt gacagtagat aatcagactg ttgatttatc gaaattaaca
    17701 gctcagactg gacaaatcac tgtaaccttt actaaaaatt aaggaaaaac gaatgaaaaa
    17761 agaacaaatt cccaatctct taacaatagg tcgaattctc tttataccta tttttatctt
    17821 tattttaacg ataggaaatt cgatagagag tcatatagtt gcagctatta tctttgctgt
    17881 tgccagtatt accgactatt tagatggata tttagctcgt aaatggaatg tggtcagtaa
    17941 ttttggtaaa tttgcagatc ctatggcgga taagttacta gttatgtcgg cttttattat
    18001 gttgattgag ttaggtatgg ctccggcttg gattgttgca gtgattatct gtcgtgagtt
    18061 agctgtgaca ggtttaaggc ttttattggt tgaaactggt ggaacaattt tagcagcagc
    18121 aatgcctgga aaaattaaaa cttttagtca gatgtttgct attattttct tgctattaca
    18181 ttggactttg cttggtcaag ttctacttta tgtagcctta tttttcacta tctactctgg
    18241 ctatgactat ttcaagggta gtgcctatgt atttaaaggg acatttggtt cgaaatgaaa
    18301 tcaataattg atgtaaaaaa tctttctttt cgctataaag aaaatcagaa ctactacgat
    18361 gtgaaggata ttacgtttca cgtgaaacgt ggagaatggc tttcgattgt agggcataat
    18421 ggtagtggta aatcaacgac ggttcgatta attgatggct tactggaagc agaatccgga
    18481 gagattgtaa ttgatggcca acgtttgact gaggaaaatg tttggaatat acgtcgtcaa
    18541 atcggtatgg tttttcaaaa tccagacaat caatttgttg gagcgactgt tgaagatgat
    18601 gttgcttttg gtttggaaaa tcagggactt tctcgtcaag aaatgaaaaa gagagtggaa
    18661 gaagctctgg ctttagttgg catgttggac tttaaaaaga gagagccagc gcgtctatca
    18721 ggtggccaaa agcaacgtgt ggccattgca ggtgttgtag ccctaagacc agctatttta
    18781 atcttagatg aagcaacgag tatgttggat cctgaggggc gtagagaact tattgggaca
    18841 gtaaaaggaa ttcgaaaaga ctatgatatg acggtcattt ctattaccca tgatttggaa
    18901 gaagtcgcca tgagtgatcg cgtattggtc atgaaaaaag gggaaattga atcaactagt
    18961 agtccagggg agcttttctc tcgaaatgat ttagatcaaa ttggattaga cgatcctttt
    19021 gctaatcaat taaaaaaatc tttgagccag aatggctatg atttacctga aaattatttg
    19081 acagaaagtg agctagagga taagctatgg gaattgctct agaaaatgtg aattttacat
    19141 atcaagaagg tactccctta gcttcagcag ctttgtcgga tgtttctttg acgattgaag
    19201 atggctctta tacagcttta attgggcaca caggtagtgg taaatcaact attttacaac
    19261 tcttaaatgg tttattggtg ccaagtcaag ggagtgtgag ggtttttgat accttaatca
    19321 cctcgacttc taaaaataaa gatattcgtc aaattagaaa acaggttggc ttggtatttc
    19381 agtttgctga aaatcagatt tttgaagaaa cggttttgaa ggacgttgct tttggaccgc
    19441 aaaattttgg agtttctgaa gaagatgctg tgaagactgc gcgtgagaaa ctggctctgg
    19501 ttggaattga tgaatcactt tttgatcgta gtccgtttga gctgtcaggg ggacaaatga
    19561 gacgtgttgc cattgcaggc atacttgcca tggagccagc tatattagtc ttagatgagc
    19621 caacagctgg tctagatcct ctagggagaa aagagttgat gaccctgttc aaaaaactcc
    19681 accagtcagg gatgaccatc gtcttggtaa cgcatttgat ggatgatgtt gctgaatatg
    19741 caaatcaagt ctatgtaatg gaaaagggac gtttagtaaa ggggggcaaa ccaagtgatg
    19801 tctttcaaga cgttgttttt atggaagaag ttcagttggg agtacctaaa attacggcct
    19861 tttgtaaacg attggctgat agaggcgtgt catttaaacg attaccgatt aagatagagg
    19921 agtttaagga gtcgctaaat ggatagtatg attttggggc gttatatccc aggggattcg
    19981 attgttcacc gattggatcc acgtagcaaa ttgcttgcta tgatgctact gattttgatt
    20041 gtgttttggg ctaataaccc cttgacgaat ctgattcttt ttatagcgac agggatattt
    20101 attgccttgt caggagtatc tctttcattt tttattcagg gcttgaagtc tatgtttttc
    20161 ttgattgcct tcacaactat ttttcaacta tttttcattt ctaatgggaa tgttttattt
    20221 gagttttcgt ttgtgagaat cacggattat gctttgcaac aagctgggat tattttttgt
    20281 cgctttgtat tgattatttt cttttcaact ttgttaacct taacaaccat gcctttaagt
    20341 ttggcatcag ctgtcgaagc tttattagca cctttaaagc gtgtgaaagt tccagttcat
    20401 gaaattggat tgatgctgtc tatgagtttg cgttttgtcc caaccttgat ggatgatacg
    20461 acgcggatta tgaatgcaca gaaagctcgt ggagtggatt ttggagaagg aagtatcgtt
    20521 caaaaagtaa aggcgatgat tcccattttg attcctcttt ttgcgacaag tttaaaacgt
    20581 gcagattcct tggctatcgc tatggaagcg cgtggctatc agggtggaaa aggcagaagt
    20641 caataccgac aattgaaatg gactctaaag gatacgctga ccattcttgt tattctcgta
    20701 cttggttgtt gtttattttt cttaaaatct tagtagcttt caggaattga taaaaagtta
    20761 ctgtaacagt ttttgatata aaggtaggga tatgaaccgt tttaaaaaat caaaatatgt
    20821 cattattgtt tttgtcactg ttctgcttgt gtcagctctc ttagcgacga cttattcaag
    20881 tacaattgtg acaaaattag gagatggaat ctcattggtt gatagagttg tacaaaaacc
    20941 ttttcagtgg tttgattctg tcaaatcaga tttggctcat ttgacacgaa catataatga
    21001 aaatgaaagt ttgaagaaac agctttacca attagaagtt aaatcaaatg aggtggaaag
    21061 tttaaagaca gaaaatgaac aactgcgcca attgcttgat atgaagtcta aattgcaagc
    21121 cacaaagact ttagcagcag atgttattat gcgttctccg gtatcttgga agcaggagtt
    21181 gaccttagat gcaggtagat caaaaggtgc ttctgagaac atgttagcta ttgcaaatgg
    21241 tggcttgatt gggagtgttt caaaagtaga ggagaactct actatagtca accttctgac
    21301 aaatacggaa aatgctgata agatttctgt taaaattcaa catggctcta ctacaattta
    21361 tggaattatt attggctatg acaaggaaaa tgacgttctt aaaattagcc aattaaatag
    21421 taatagcgat attagtgcgg gagataaggt gactactggt ggattaggaa actttaacgt
    21481 tgctgatatt cctgttggtg aagtggttgc cacaacgcat agtacagact atttgacacg
    21541 agaagtaact gttaaattga gtgcagatac tcataatgta gatgtgatag aattagtggg
    21601 gaattcataa tgagacagtt gaagcgagtt ggagtatttt tattgcttcc tttctttgtt
    21661 ctaattgacg cccatattag ccagcttctg ggctcatttt tcccccatgt acatttggct
    21721 agtcattttc tttttctatt tctcttattt gagacgatag aagtatcaga gtatctctac
    21781 ctagtctatt gttttgttat aggcttggtt tatgatgttt actttttcca tctaataggg
    21841 attacaactc tcttatttat cttattggga gccttccttc ataaattgaa tagtgttatt
    21901 ttgttgaatc gttggacaag aatgctagct atgattgtgc tgacattcct gtttgaaatg
    21961 ggtagttatc ttttggcttt tatggtaggg ttgacagtag atagcatgtc gatttttata
    22021 gtctatagct tggtaccgac gatgatttta aattttttat ggattactgt ttttcaattt
    22081 atttttgaaa aatattatct ataagaacga catataaatg taacaaaggc gtaatattta
    22141 ttaggccttt ttttggtata ctagtattgt ctttaaaaga aggagtatct acgtaatatg
    22201 aagaaaaaaa tcttagcgtc acttttatta agtacagtaa tggtttctca agtagctgtt
    22261 ttaacaactg cgcatgcaga aacgactgat gacaaaattg ctgctcaaga taataaaatt
    22321 agtaacttaa cagcacaaca acaagaagcc caaaaacaag ttgaccaaat tcaggagcaa
    22381 gtatcagcta ttcaagctga gcagtctaac ttgcaagctg aaaatgatag attacaagca
    22441 gaatctaaga aactcgaggg tgagattaca gaactttcta aaaacattgt ttctcgtaac
    22501 caatcgttgg aaaaacaagc tcgtagtgct caaacaaatg gagccgtaac tagctatatc
    22561 aataccattg taaactcaaa atcaattaca gaagctattt cacgtgttgc tgcaatgagt
    22621 gaaatcgtat ctgcaaacaa caaaatgtta gaacaacaaa aggcagataa aaaagctatt
    22681 tctgaaaaac aagtagcaaa taatgatgct atcaatactg taattgctaa tcaacaaaaa
    22741 ttggctgatg atgctcaagc attgactacg aaacaggcag aactaaaagc tgctgaatta
    22801 agtcttgctg ctgagaaagc gacagctgaa ggggaaaaag caagtctatt agagcaaaaa
    22861 gcagcagctg aggcagaggc tcgtgcagct gcggtagcag aagcagctta taaagaaaaa
    22921 cgagctagcc aacaacaatc agtacttgct tcagcaaaca ctaacttaac agctcaagtg
    22981 caagcagtat ctgaatctgc agcagcacct gtccgtgcaa aagttcgtcc aacatacagt
    23041 acaaatgctt caagttatcc aattggagaa tgtacatggg gagtaaaaac attggcacct
    23101 tgggctggag actactgggg taatggagca cagtgggcta caagtgcagc agcagcaggt
    23161 ttccgtacag gttcaacacc tcaagttgga gcaattgcat gttggaatga tggtggatat
    23221 ggtcacgtag cggttgttac agctgttgaa tcaacaacac gtatccaagt atcagaatca
    23281 aattatgcag gtaatcgtac aattggaaat caccgtggat ggttcaatcc aacaacaact
    23341 tctgaaggtt ttgttacata tatttatgca gattaattta cagagggact cgaatagagc
    23401 cctcttttca ggttttaccg tgacaatctc tattaaaaat tatatcaaaa tagcttgaaa
    23461 atattggaaa agtatggtag aatgaaaatt gtcgtgtgaa cgataatact cattcttgat
    23521 gaattgtgaa gcagttgccc ttgggtcgtt ttgcgagttg aagtcaagaa gaggaaaaaa
    23581 acaaaaagga gaaatactca tggcagtaat ttcaatgaaa caacttcttg aggctggtgt
    23641 acactttggt caccaaactc gtcgctggaa tcctaagatg gctaagtaca tctttactga
    23701 acgtaacgga atccacgtta tcgacttgca acaaactgta aaatacgctg accaagcata
    23761 cgacttcatg cgtgatgcag cagctaacga tgcagttgta ttgttcgttg gtactaagaa
    23821 acaagcagct gatgcagttg ctgaagaagc agtacgttca ggtcaatact tcatcaacca
    23881 ccgttggttg ggtggaactc ttacaaactg gggaacaatc caaaaacgta tcgctcgttt
    23941 gaaagaaatt aaacgtatgg aagaagatgg aactttcgaa gttcttccta agaaagaagt
    24001 tgcacttctt aataaacaac gtgcgcgtct tgaaaaattc ttgggcggta tcgaagatat
    24061 gcctcgtatc ccagatgtga tgtacgtagt tgacccacat aaagagcaaa tcgctgttaa
    24121 agaagctaaa aaattgggaa tcccagttgt agcgatggtt gacaccaata ctgatccaga
    24181 tgatatcgat gtaatcatcc cagctaacga tgacgctatc cgtgctgtta aattgatcac
    24241 agctaaattg gctgacgcta ttatcgaagg acgtcaaggt gaggatgcag tagcagttga
    24301 ggcagaattt gcagcttcag aaactcaagc agattcaatt gaagaaatcg ttgaagttgt
    24361 agaaggtgac aacgcttaat ttatacaaat agtaattacc taggagggcg gggcttagcc
    24421 cggctctcct attttcaaaa aatataggag aattaaaatg gcagaaatta cagctaaact
    24481 tgtaaaagag ttgcgtgaaa aatctggtgc cggtgttatg gacgctaaaa aagcgcttgt
    24541 agaaacagac ggtgacatcg aaaaagcgat tgaattgctt cgtgaaaaag gtatggctaa
    24601 ggcagctaag aaagctgacc gtgttgctgc agaaggtttg actggtgttt atgttaacgg
    24661 taatgttgca gcagttattg aagtaaacgc tgaaactgac ttcgttgcaa aaaacgctca
    24721 attcgttgaa ttggtaaata ctacagctaa agtcattgct gaaggaaaac ctgctaacaa
    24781 cgaagaagct cttgctttga taatgccttc aggtgaaact cttgaagctg catacgtatc
    24841 tgcaacagca actataggag agaaaatctc attccgtcgc tttgcattga ttgaaaaaac
    24901 agacgcacaa cactttggag cataccaaca taacggtgga cgtatcggtg ttatttcagt
    24961 tgttgaagat ggagacgaag cacttgctaa acaattgtca atgcacatcg cagcgatgaa
    25021 accaacagtt ctttcttaca aagaattgga tgagcaattc gttaaagatg agttggcaca
    25081 attgaatcac gttatcgacc aagacaacga aagccgtgca atggttaata aaccagctct
    25141 tccacacttg aagtatggat caaaagctca attaactgat gatgttattg ctcaagctga
    25201 agctgacatc aaagctgaat tggctgcaga aggcaaacca gaaaaaatct gggacaaaat
    25261 tattccaggt aaaatggatc gcttcatgct tgataacact aaagttgacc aagcttacac
    25321 acttcttgca caagtttaca tcatggatga cagcaagaca gttgaagcat accttgaatc
    25381 agttaacgct tcggtagttg agtttgctcg ctttgaagtt ggtgaaggta tcgagaaagc
    25441 tgcaaacgac ttcgaagctg aagttgcagc tacaatggca gcagccttga ataactaata
    25501 atagaaagga agcaaattgc ttcctttttt gtatagggct tagatttttc ctgaaattgt
    25561 tttttcccca gtctcactcg attagaataa ttaaaacaaa aagccctata ataagggc
//
LOCUS       DAVLHC010000029        23953 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.029, whole genome shotgun sequence.
ACCESSION   DAVLHC010000029 DAVLHC010000000
VERSION     DAVLHC010000029.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 23953)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 23953)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..23953
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.029"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(105..2363)
                     /locus_tag="VXE25_001357"
     CDS             complement(105..2363)
                     /locus_tag="VXE25_001357"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit"
                     /protein_id="HEV0771811.1"
                     /translation="MLCQNCKINDSTIHLYTNLNGKQKQIDLCQNCYKIIKTDPNNSL
                     FKGMTDLNNRDFDPFGDFFNDLNNFRPSSNTPPIPPTQSGGGYGGNGGYGSQNRGSAQ
                     TPPPSQEKGLLEEFGINVTEIARRGDIDPVIGRDDEIIRVIEILNRRTKNNPVLIGEP
                     GVGKTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEI
                     RKREDIILFIDEIHEIVGAGSASDGNMDAGNILKPALARGELQLVGATTLNEYRIIEK
                     DAALERRMQPVKVDEPTVDETITILKGIQKKYEDYHHVQYTDAAIEAAATLSNRYIQD
                     RFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKSQATREEDFEKAAYFRD
                     QIAKYKEMQKKKITDQDTPIISEKTIEHIIEQKTNIPVGDLKEKEQSQLIHLAEDLKS
                     HVIGQDDAVDKIAKAIRRNRVGLGTPNRPIGSFLFVGPTGVGKTELSKQLAIELFGSA
                     DSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRHNPYSLILLDEVEKAHP
                     DVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKTEASVGFGAAREGRTNSV
                     LGELGNFFSPEFMNRFDGIIEFKALSKDNLLQIVELMLADVNKCLSSNNIRLDVTDKV
                     KEKLVDLGYDPKMGARPLRRTIQDYIEDTITDYYLENPSEKDLKAVMTSKGNIQIKSA
                     KKAEVKSSEKEK"
     gene            complement(2592..2822)
                     /locus_tag="VXE25_001358"
     CDS             complement(2592..2822)
                     /locus_tag="VXE25_001358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005592360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YkuJ family protein"
                     /protein_id="HEV0771812.1"
                     /translation="MESHLVRIINRLEAMANDGGNLKRNFEREGVVVAEVAYSHDEEN
                     GPIFTLRDVEDRETYTFDSIDLIAMEIYELLY"
     gene            3012..3695
                     /locus_tag="VXE25_001359"
     CDS             3012..3695
                     /locus_tag="VXE25_001359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001011621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEV0771813.1"
                     /translation="MNFSFLPKYLPYFNYGAVVTILISICVIFLGTILGVVLAFGQRS
                     KFKPLVWLANLYVWIFRGTPMMVQIMIAFALMHINAPTIQIGILGVDFSRLIPGILII
                     SMNSGAYVSETVRAGINAVPKGQLEAAYSLGIRPKNAMRYVILPQAVKNILPALGNEF
                     ITIIKDSSLLSAIGVMELWNGATTVSTTTYLPLTPLLFAAFYYLIMTSILTVALKAFE
                     KHMGQGDKK"
     gene            3695..4429
                     /locus_tag="VXE25_001360"
     CDS             3695..4429
                     /locus_tag="VXE25_001360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000140960.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEV0771814.1"
                     /translation="MTETLIKIENLHKSFGKNEVLKGINLEIKRGEVVVIIGPSGSGK
                     STLLRSMNLLEEATKGKLIFEGVDITDKKNDLFAMREKMGMVFQQFNLFPNMTVMENI
                     TLSPIKTKGESREVAEKRAQELLEKVGLPDKADAYPQSLSGGQQQRIAIARGLAMEPD
                     VLLFDEPTSALDPEMVGEVLAVMQDLAKSGMTMVIVTHEMGFAREVADRVIFMADGVV
                     VEDGTPEQIFEQTQEQRTKDFLSKVL"
     gene            4583..5440
                     /locus_tag="VXE25_001361"
     CDS             4583..5440
                     /locus_tag="VXE25_001361"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000192112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional methylenetetrahydrofolate
                     dehydrogenase/methenyltetrahydrofolate cyclohydrolase"
                     /protein_id="HEV0771815.1"
                     /translation="MTQIIDGKALAAKLQGQLAEKTAKLKEETGLVPGLVVILVGDNP
                     ASQVYVRNKERSALAAGSRSEVVRVPETITQEELLDLIAKYNQDPAWHGILVQLPLPK
                     HIDEEAVLLAIDPEKDVDGFHPLNMGRLWSGHPVMIPSTPAGIMEMFHEYGIDLEGKN
                     AVVIGRSNIVGKPMAQLLLAKNATVTLTHSRTHNLAKVAAKADILVVAIGRAKFVTAD
                     FVKPGAVVIDVGMNRDENGKLCGDVDYEAVAPLASYITPVPGGVGPMTITMLMEQTYQ
                     AALRTLDRK"
     gene            5582..6454
                     /locus_tag="VXE25_001362"
     CDS             5582..6454
                     /locus_tag="VXE25_001362"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000864675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-hydrate dehydratase"
                     /protein_id="HEV0771816.1"
                     /translation="MKVINQTLLEKVIIERSRSSHKGDYGRLLLLGGTYPYGGAIIMA
                     ALAAVKSGAGLVTVGTDRENIPALHSHLPEPMAFSLQDQQLLKEQLEKAEVVLLGPGL
                     RDDASGENLVKQVFVNLSQNQILIVDGGALTILARTSLSFPSSQLILTPHQKEWEKLS
                     GITIEKQKEDATASVLTSFPQGTILVEKGPATRIWEVGQSDYYQLQVGGPYQATGGMG
                     DTLAGMIAGFVGQFRQASLYERVAVATHLHSAIAQELSQENYVVLPTEISRYLPKIMK
                     IICQQERVSKDKLV"
     gene            6736..7419
                     /gene="rpiA"
                     /locus_tag="VXE25_001363"
     CDS             6736..7419
                     /gene="rpiA"
                     /locus_tag="VXE25_001363"
                     /EC_number="5.3.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000429260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-5-phosphate isomerase RpiA"
                     /protein_id="HEV0771817.1"
                     /translation="MENLKKMAGIKAAEFVSDGMVVGLGTGSTAYYFVEEIGRRIKEE
                     GLQITAVTTSSVTTKQAEGLNIPLKSIDQVDFVDVTVDGADEVDSQFNGIKGGGGALL
                     MEKVVATPSKEYIWVVDESKLVEKLGAFKLPVEVVQYGAEQVFRHFERAGYKPSFREK
                     DGQRFVTDMQNFIIDLALDVIENPIAFGQELDHVVGVVEHGLFNQMVDKVIVAGRDGV
                     QISTSKKGK"
     gene            7433..8644
                     /locus_tag="VXE25_001364"
     CDS             7433..8644
                     /locus_tag="VXE25_001364"
                     /EC_number="5.4.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004259464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopentomutase"
                     /protein_id="HEV0771818.1"
                     /translation="MSKFNRIHLVVLDSVGIGAAPDANNFVNAGVPDGASDTLGHISK
                     TVGLNVPNMAKIGLGNIPRETPLKTVAAEINPTGYATKLEEVSLGKDTMTGHWEIMGL
                     NITEPFDTFWNGFPEEILTKIEEFSGRKVIREANKPYSGTAVIDDFGPRQMETGELII
                     YTSADPVLQIAAHEDIIPLDELYRICEYARSITLERPALLGRIIARPYVGEPGNFTRT
                     ANRRDLAVSPFSPTVLDKLNEAGIDTYAVGKINDIFNGAGINHDMGHNKSNSHGIDTL
                     LKTMGLAEFEKGFSFTNLVDFDALYGHRRNAHGYRDCLHEFDERLPEIIAAMRENDLL
                     LITADHGNDPTYAGTDHTREYIPLLAYSPAFKGNGLIPVGHFADISATVADNFGVETA
                     MIGESFLDKLV"
     gene            8646..9203
                     /locus_tag="VXE25_001365"
                     /pseudo
     CDS             8646..9203
                     /locus_tag="VXE25_001365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000199123.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1697 domain-containing protein"
     gene            9203..10012
                     /locus_tag="VXE25_001366"
     CDS             9203..10012
                     /locus_tag="VXE25_001366"
                     /EC_number="2.4.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine-nucleoside phosphorylase"
                     /protein_id="HEV0771819.1"
                     /translation="MTFLNKIHETATFLKEKGIAAPEFGLILGSGLGELAEEIENPVV
                     VDYAEIPNWGRSTVVGHAGKLVYGELAGRKVLALQGRFHFYEGNPLEVVTFPVRVMKV
                     LGCEGVIVTNAAGGIGFGPGTLMAISDHINMTGQNPLMGENLDDFGPRFPDMSRAYTP
                     EYRATAHEVAKKLNIKLDEGVYIGVTGPTYETPAEIRSYKTLGADAVGMSTVPEVIVA
                     AHSGLKVLGISCITNFAAGFQEELNHEEVVEVTERVKGDFKGLLKAILAEL"
     gene            10723..11472
                     /locus_tag="VXE25_001367"
     CDS             10723..11472
                     /locus_tag="VXE25_001367"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000145697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="discoidin domain-containing protein"
                     /protein_id="HEV0771820.1"
                     /translation="MTGHFLGCYLAQIAAVEAYQKYPDFYNHVLRRVTTFSAPKVITS
                     RTVWNAKNGFWDVGLESRKLAVSGKIKHYVVDNDNVVTPLIHNDRDIVTFTGNSRFKH
                     RSRGYFESPMNDIPNFNIGKQATFDKHGYRDPKLDKVRFFKKQALPQSSSQPSAEPME
                     NIALGKQVTQSSTAFGGDARRAVDGKVDGNYGHNSVTHTNFQSKPWWQVDLAKEETIR
                     QINIYNRTDTAQDRLANFDVILLDSSGKEIE"
     gene            11495..12010
                     /locus_tag="VXE25_001368"
     CDS             11495..12010
                     /locus_tag="VXE25_001368"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hemolysin"
                     /protein_id="HEV0771821.1"
                     /translation="MCQHKLRLTIKKARYVRIELEGYNALSLAEVEVFRFIATNGETA
                     IQVSKSVQPISQTPVKDKTLTIQHSGAYIARYSITWEEVTVDKDGNQVVRSHSWEGNG
                     RNQTAGFVLNLPIKENMRNLRVKIEKKTGLLWNRWQTIYENRPILAQPHRKITHWGTT
                     LNSKVSDDDVL"
     gene            12664..13374
                     /gene="deoD"
                     /locus_tag="VXE25_001369"
     CDS             12664..13374
                     /gene="deoD"
                     /locus_tag="VXE25_001369"
                     /EC_number="2.4.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine-nucleoside phosphorylase"
                     /protein_id="HEV0771822.1"
                     /translation="MSIHIAAQQGEIADKILLPGDPLRAKFIAENFLDDAVCFNEVRN
                     MFGYTGTYKGHCVSVMGTGMGMPSISIYARELIVDYGVKKLIRVGTAGSLNEEVHVRE
                     LVLAQAAATNSNIVRNDWPQYDFPQIASFDLLDKAYHIAKKFGMTTHVGNVLSSDVFY
                     SNYFEKNIELGKWGVKAVEMEAAALYYLAAQYHVDALAIMTISDSLVNPDEDTTAEER
                     QNTFTDMMKVGLETLIAE"
     gene            complement(13397..13921)
                     /locus_tag="VXE25_001370"
     CDS             complement(13397..13921)
                     /locus_tag="VXE25_001370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000684222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topology modulation protein"
                     /protein_id="HEV0771823.1"
                     /translation="MKITIIGYSGSGKSTLAEKLSNYYSIPKLHMDTLQFQPGWQDSD
                     CEWMLTEIKNFLTKHKAWVIDGNYSWCYYQERMQEADQIIFLNFLPLTCLFRAFKRYL
                     KYRGKVRESMAADCPERFEWEFIRWILWDGRSKTQKENYQKLCQEYSHKVTILRNQRE
                     LDQFLDKKRKSYNS"
     gene            complement(13974..14210)
                     /locus_tag="VXE25_001371"
     CDS             complement(13974..14210)
                     /locus_tag="VXE25_001371"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001274003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S20"
                     /protein_id="HEV0771824.1"
                     /translation="MANIKSAIKRAELNVKQNEKNSAQKSAMRTAIKAFEANPSEELF
                     RAASSAIDKAETKGLIHKNKASRDKARLSAKLAK"
     gene            complement(14278..15198)
                     /locus_tag="VXE25_001372"
     CDS             complement(14278..15198)
                     /locus_tag="VXE25_001372"
                     /EC_number="2.7.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I pantothenate kinase"
                     /protein_id="HEV0771825.1"
                     /translation="MTNEFLHFEKISRQTWQSLHRKTTPPLTEEELESIKSFNDQISL
                     QDVTDIYLPLAHLIQIYKRTKEDLAFSKGIFLQRESKSQPFIIGVSGSVAVGKSTTSR
                     LLQILLSRTFTDATVELVTTDGFLYPNQTLIEQGILNRKGFPESYDMEALLNFLDRIK
                     NGQDVDIPVYSHEVYDIVPEEKQSVKAADFVIVEGINVFQNPQNDRLYITDFFDFSIY
                     VDAGVDDIESWYLDRFLKMLSLAQNDPDSYYYRFTQMPIGEVEAFAHQVWTSINLTNL
                     QNYIEPTRNRAEVILHKSKNHEIDEIYLKK"
     gene            15396..15800
                     /locus_tag="VXE25_001373"
     CDS             15396..15800
                     /locus_tag="VXE25_001373"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771826.1"
                     /translation="MKILKRYILELCFILSFALPFIKGANADNGICFVETYYGFTFLM
                     EHAIVTAVFIYSFSIAFLLKKRWAKWIAAGSYCFLVLWIATEGYFFRMSLEDLIRLWT
                     SLEILTQTYQLGFYLNILLGILLIIKYFKVKQ"
     gene            16016..16597
                     /locus_tag="VXE25_001374"
     CDS             16016..16597
                     /locus_tag="VXE25_001374"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000289981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HEV0771827.1"
                     /translation="MYYAENPDAAHDIHELRVELLGQKMTFLTDAGVFSKKIVDFGSQ
                     LLLKCLEVNQGETVLDVGCGYGPLGLSLAKAYGVQATMVDINTRALDLARRNAEKNNA
                     KATIFQSNIYEQVEGHFDHVISNPPIRAGKQVVHEIIEKSKDFLETGGDLTIVIQKKQ
                     GAPSAKSKMEDVFGNCEILKKDKGYYILRSVKE"
     gene            16594..17871
                     /locus_tag="VXE25_001375"
     CDS             16594..17871
                     /locus_tag="VXE25_001375"
                     /EC_number="2.4.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001202959.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrimidine-nucleoside phosphorylase"
                     /protein_id="HEV0771828.1"
                     /translation="MRAVDLIQKKRDGQELTSSEIEWLVEGYVSGTVPDYQMSAFAMA
                     VYFKGMTTREISDLTMNMVKTGQEFDLSAIDGVKVDKHSTGGVGDKVTLILAPLVASF
                     GVPVAKMSGRGLGHTGGTIDKLESIRGYQVERSQEDFIRQVQDIGVSVIGQSDQLVKA
                     DKLLYALRDVTATVDTIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVDEARELA
                     QTMVDLGKVVGRKTVAVITDMSQPLGRAIGNRLEILEALEILQGQGRQDITHFICELA
                     QIMLGLANVNKTVEEVRQHLEDGQALAKFEEMVQAQGGDLEDLYRPVNVAHVVEIPAQ
                     ETGVISALPAMDFGLYAMRLGAGRAVKSDALDYETGIVFEKKIGDSVQKGEIVAKVYT
                     NEKIPPQLVTDFQKCVKISDEVKKIREIVEIIS"
     gene            17889..18551
                     /gene="deoC"
                     /locus_tag="VXE25_001376"
     CDS             17889..18551
                     /gene="deoC"
                     /locus_tag="VXE25_001376"
                     /EC_number="4.1.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000773666.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="deoxyribose-phosphate aldolase"
                     /protein_id="HEV0771829.1"
                     /translation="MKLNKYIDHTLLKQDAKKKQIDSLLSEAREYGFASVCVNPTWVE
                     HAKKGLEGTDVKVCTVVGFPLGATTSAVKAFETKEAIQNGADEIDMVINVGALKSGNL
                     ALVESDIRAVVEASGDKLVKVIIEACLLTDQEKVVVCQLAQKAGADFVKTSTGFSTGG
                     ATIADVTLMRETVGSDMGVKAAGGARSYADALAFVEAGATRIGTSAGVAILKGELADG
                     DY"
     gene            18538..18927
                     /locus_tag="VXE25_001377"
     CDS             18538..18927
                     /locus_tag="VXE25_001377"
                     /EC_number="3.5.4.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine deaminase"
                     /protein_id="HEV0771830.1"
                     /translation="MATTELIELAIETSKHAYVPYSHFPIGAVLVAKDGNVYTGVNIE
                     NASYPLTNCGERTAIFKAISEGQREFSELIVYGQTEKPISPCGACRQVMVEFFEQDLK
                     VTLVAKDKSTVEMTVGELLPYSFTDLN"
     gene            19018..20070
                     /locus_tag="VXE25_001378"
     CDS             19018..20070
                     /locus_tag="VXE25_001378"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMP family protein"
                     /protein_id="HEV0771831.1"
                     /translation="MNKKQWLGLGLVAVAAVGLAACGNRSSRNAASSSDVKTKAAIVT
                     DTGGVDDKSFNQSAWEGLQAWGKEHNLSKDNGFTYFQSTSEADYANNLQQAAGSYNLI
                     FGVGFALHNAVEEAAKEHTDLNYVLIDDVIKDQKNVASVTFADNESGYLAGVAAAKTT
                     KTKQVGFVGGIESEVISRFEAGFKAGVASVDPSIKVQVDYAGSFGDAAKGKTIAAAQY
                     AAGADIVYQVAGGTGAGVFAEAKSLNESRPENEKVWVIGVDRDQEAEGKYTSKDGKES
                     NFVLVSTLKQVGTTVKDISNKAEKGEFPGGQVIVYSLKDKGVDLAVTNLSEEGKKAVE
                     DAKAKILDGSVKVPEK"
     gene            20214..21749
                     /locus_tag="VXE25_001379"
     CDS             20214..21749
                     /locus_tag="VXE25_001379"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000929819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0771832.1"
                     /translation="MAHENVIEMRDITKVFGGFIANDKINLHLRKGEIHALLGENGAG
                     KSTLMNMLAGLLEPTSGEIAVNGQVVNLDSPSKAASLGIGMVHQHFMLVEAFTVAENI
                     ILGSELTKNGVLDIAGASKEIKALSERYGLAVDPSAKVADISVGAQQRVEILKTLYRG
                     ADILIFDEPTAVLTPSEIDELMAIMKNLVKEGKSIILITHKLDEIRAVSDRVTVIHRG
                     KSIETVEIAGATNADLAEMMVGRSVSFKTEKQASKPKEVVLSIKDLVVNENRGVPAVK
                     NLSLDVRAGEIVGIAGIDGNGQSELIQAITGLRKVESGSIELKGDSIVGLHPRQITEL
                     SVGHVPEDRHRDGLILEMMISENIALQTYYKEPHSKNGILNYSNITSYAKKLMEEFDV
                     RAASELVPAAALSGGNQQKAIIAREIDRDPDLLIVSQPTRGLDVGAIEYIHKRLIEER
                     DNGKAVLVVSFELDEILNVSDRIAVIHDGKIQGIVSPETTNKQELGVLMAGGNLGKEK
                     SDV"
     gene            21742..22800
                     /locus_tag="VXE25_001380"
     CDS             21742..22800
                     /locus_tag="VXE25_001380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000038644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEV0771833.1"
                     /translation="MSKKLQQISVPLISVFLGILLGAIVMWIFGYDAIWGYEELFYTA
                     FGSLRGIGEIFRAMGPLVLIGLGFAVASRAGFFNVGLPGQALAGWILSGWFALSHPDM
                     PRPLMILATIVIALIAGGIVGAIPGILRAYLGTSEVIVTIMMNYIVLYVGNAFIHAFP
                     KDFMQSTDSTIRVGANATYQTPWLAELTGNSRMNIGIFFAIIAVAVIWFMLKKTTLGF
                     EIRAVGLNPHASEYAGISAKRTIILSMIISGALAGLGGAVEGLGTFQNVYVQGSSLAI
                     GFNGMAVSLLAANSPIGILFAAFLFGVLQVGAPGMNAAQVPSELVSIVTASIIFFVSV
                     HYLIERFVKPKKQVKGGK"
     gene            22803..23759
                     /locus_tag="VXE25_001381"
     CDS             22803..23759
                     /locus_tag="VXE25_001381"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEV0771834.1"
                     /translation="MSIITLLPLLVSSMLIYSAPLIFTSIGGVFSERGGVVNVGLEGI
                     MVMGAFSGVVFNLEFAEQFGAATPWLSLLVAGLVGSVFSIIHAAATVHFRADHVVSGT
                     VLNLMAPALAVFLVKVLYNKGQTDNLSQTFGRFDFPVLANIPVIGDIFFKSTSLLGYL
                     AIAFSFLAWFILFKTQFGLRLRSVGEHPQAADTLGINVYKMRYLGIIISGFLGGIGGA
                     IYAQSISVNFSVTTIVGPGFIALAAMIFGKWNPIGAMLSSLFFGLSQSLAVIGSQLPF
                     LQGVPAVYLQIAPYVLTILVLAAFFGKAVAPKADGINYIKSK"
     gene            23844..>23953
                     /locus_tag="VXE25_001382"
     CDS             23844..>23953
                     /locus_tag="VXE25_001382"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEV0771835.1"
                     /translation="MKLSYDDKVQIYELRKQGYSLEKLSNKFGINNSNLR"
BASE COUNT         6979 a         4306 c         5440 g         7228 t
ORIGIN      
        1 actatatatc ataatggaca aagggcaagc tgtcaagaaa ttacagttat tttagtaaaa
       61 aaagaagcag aaaaatttca ttttctactc cttttctata ggatttattt ttctttttca
      121 gaacttttaa cttcagcttt tttggcagat ttaatctgaa tgtttccctt gctagtcata
      181 actgctttga gatctttttc gcttggattt tcaaggtagt agtcagtgat tgtgtcctca
      241 atatagtctt gaatagtccg acgaagtggg cgtgctccca tttttggatc ataacctagg
      301 tcaaccaact tttccttgac cttgtcagtt acatccaaac gaatgttgtt gctagagagg
      361 cacttgttaa catctgctag catgagctcg acaatctgaa ggaggttatc cttgctgaga
      421 gccttaaatt cgataatgcc atcaaaacgg ttcataaact ctgggctaaa gaagttaccg
      481 agttcaccga ggacagaatt ggtacgtcct tctctagcag caccaaatcc aacgctagct
      541 tcggtctttc ctgtacctgc atttgaggtc atgataatga tggcatcctt gaagctaacg
      601 gtgcgtcctt gcccgtctgt caaacgacca tcgtccaaga cttgaagaaa catgtgcata
      661 acatctgggt gagctttttc cacttcatcg agaaggatga gagaatatgg attgtggcga
      721 actttttcag ttaattgacc agcctcatca tagccaacat aacctggagg agcgccgacc
      781 aacttagcca cactatgttt ttccatgtat tcactcatat caaagcgaat catactatca
      841 gcagaaccaa aaagttcgat agccagttgt ttggaaagtt ctgtcttgcc gacaccagtt
      901 ggcccaacga agaggaagct tccgattggg cggttagggg taccaagtcc gacacgatta
      961 cggcgaatag ccttggcaat cttatcgact gcatcatctt ggccaataac atgagacttg
     1021 agatcttcgg ctagatggat gagttgagat tgttctttct ctttcaaatc accaacaggg
     1081 atattggttt tctgctcgat aatgtgctca atagttttct cgctgatgat aggagtatcc
     1141 tggtctgtga tctttttctt ttgcatttcc ttatacttgg caatctggtc gcggaagtag
     1201 gccgccttct caaaatcttc ttctcgtgta gcttgagact tgagattttc agcctcaatc
     1261 aagcgctgat caattacttt aggatccaca aaattcaagg tcaagttcat cttagaacca
     1321 gcttcatcta ggaggtcaat ggccttgtca ggcaagaagc gatcttggat gtagcgattg
     1381 gaaagagttg cagctgcttc aatcgcagca tcggtatatt gaacgtggtg gtaatcttcg
     1441 tatttctttt gaatcccttt gagaatagtg attgtttcat ccaccgttgg ttcatcgact
     1501 ttaacaggct gcatacgacg ctcgagggca gcatcctttt caatgatacg gtattcattg
     1561 agggtagtag caccgactag ttgcagttct ccacgagcaa gggctggctt gaggatattt
     1621 cctgcgtcca tattaccatc actcgcagaa ccagcaccaa caatttcatg gatttcatcg
     1681 ataaagagga tgatgtcttc acgtttgcga atttcttcca tgagtttttg catgcgttct
     1741 tcaaattgtc ctcgaatccc cgttccttga actaagctaa ccacatccag acggatgact
     1801 tgtttacctt ggagtttatg tggcacatcg ccatcgacaa ttttctgagc tagaccttcg
     1861 acaacggccg tttttccgac accaggttca ccgataagga caggattatt cttggttcta
     1921 cgattgagaa tctcgatgac acggataatc tcatcgtcgc gcccaataac ggggtcaatg
     1981 tctccacgac gggcaatttc agttacatta ataccaaatt cttccagcag gcctttttct
     2041 tggctaggtg gcggagtttg agcagatcca cgattttggg aaccataacc gccgtttcca
     2101 ccgtaacctc cacctgattg ggttggggga ataggaggag tattgctaga aggtctgaaa
     2161 ttgtttagat cattgaagaa atcaccaaag ggatcgaagt cacgattgtt cagatccgtc
     2221 atacctttga agaggctatt gttaggatct gttttgataa tcttatagca gttttgacag
     2281 aggtcaattt gtttttgttt tccattgaga ttggtgtaaa gatgaattgt tgagtcgtta
     2341 attttacagt tttgacaaag catacatcta cctcatttct ttctttagcc tgacttgttt
     2401 aaaggtcaaa aatagtcaaa ttctatactc tcattataac aggattgggg tgtaaagcaa
     2461 gtaaaaagat tgaagctttg agaagttgtt acaatgaaaa tttttgtgaa tttggactat
     2521 aaaaaaatcc tatttgtgag acaaaaagga ttttacttag acatgcaggg acaatcccag
     2581 cttgttttag attagtagag aagttcgtaa atttccattg cgattaagtc aatgctatca
     2641 aacgtatacg tttcgcgatc ttctacgtca cgaagggtaa agattgggcc gttttcttcg
     2701 tcgtggctgt acgcaacttc tgcaacaaca actccttcgc gttcaaaatt acgttttaaa
     2761 tttccgccat cgtttgccat tgcttcaagg cggttgatga ttctaaccaa atgtgattcc
     2821 attttgattc tccttcattt cttatcgtta ctattttacc ataaaggagg ccaacttgac
     2881 tagaaaaaac taagatttct cgttaattct gctagtttaa agatttttaa ataaattgga
     2941 taaaaaattt aaattttaat tcaaaacatg ttataatcat acagtattct attttagaaa
     3001 gcagtgtgac tatgaatttt tcttttttac ctaagtattt accttatttt aactatgggg
     3061 ctgttgtgac gattcttatt tctatctgtg ttatcttttt gggaactatt ttgggtgttg
     3121 tcttggcttt tgggcaacgt tcaaagttta aaccgcttgt ttggttggcc aacttgtacg
     3181 tttggatttt ccgtgggaca ccgatgatgg ttcaaattat gattgccttt gctcttatgc
     3241 atatcaatgc tccgactatt cagattggaa ttttaggtgt tgatttttcg cgtctgattc
     3301 cagggatttt gattatctct atgaatagtg gtgcttatgt ttcggagact gttcgtgccg
     3361 gaatcaatgc ggttccaaaa ggtcagctag aggcggctta ttcgctaggg attcgtccta
     3421 aaaatgcgat gcgttatgtg attttgccac aagcagtcaa aaatatcttg ccagcattgg
     3481 ggaacgaatt tatcaccatt atcaaggaca gctccctctt atcagctatt ggggtcatgg
     3541 agttgtggaa tggggctaca acagtttcta caacaaccta tctaccttta acaccacttt
     3601 tatttgcagc attttactac ttgattatga cctctattct gacagtagcc ttgaaagctt
     3661 ttgaaaaaca tatgggacaa ggagataaga aataatgaca gaaaccttga taaaaattga
     3721 aaatttacat aaatcttttg gaaagaatga agtattgaag ggcatcaacc tcgagattaa
     3781 aagaggagaa gttgtcgtta tcatcggtcc ttcagggagt gggaaatcta ccttgcttcg
     3841 ctctatgaat ttgttggagg aagcaaccaa ggggaagctt atctttgagg gagtcgatat
     3901 tacggacaag aagaatgacc tgtttgccat gcgtgagaag atgggcatgg ttttccaaca
     3961 atttaacctc tttcctaata tgactgtgat ggaaaatatt accttgtcac ctatcaagac
     4021 taaaggtgaa agcagggaag ttgctgagaa gagagcccaa gagcttttgg aaaaagttgg
     4081 tttgccagat aaggcagacg cttatccaca gagtctgtcg ggtgggcaac aacaacggat
     4141 tgccatcgcg cgtgggttgg ctatggaacc agatgttttg ctctttgacg aaccaacttc
     4201 agccttggat cctgaaatgg taggtgaggt attggctgtt atgcaagacc ttgccaagtc
     4261 agggatgact atggttatcg taacacatga gatgggattt gcccgtgagg tggcagatcg
     4321 tgttatcttt atggcagacg gtgtggttgt tgaagatggg acacctgagc agatttttga
     4381 acaaacccaa gaacaacgga ctaaagattt cttgagtaag gttttataat ctattttaaa
     4441 atttcaagac aagattagtg aaaagttcaa ccagagcttt ttcttatagt ttgaaactat
     4501 aggataacct aggaaagaag tgttagaggg cactagcagt ttttggtata atggaagata
     4561 tttgaaagaa aagagaagtg atatgacaca gattattgat gggaaagctt tagcggccaa
     4621 attgcagggg cagttggctg aaaagactgc aaaattaaag gaagaaacag gtctagtgcc
     4681 tggtttggta gtgattttgg ttggggataa tccagccagc caagtctacg ttcgcaacaa
     4741 ggagaggtca gctcttgcgg ctggttcccg tagcgaagta gtgcgagttc cagagaccat
     4801 tactcaagag gaattgttag acctgattgc taaatataat caggatccag cttggcatgg
     4861 gattttggtc cagttgccat taccaaaaca tatcgatgaa gaggcggttt tattagccat
     4921 tgatccagaa aaggatgtgg atggtttcca tcccctaaac atgggacgtc tttggtctgg
     4981 acatccagtc atgattccct cgacacctgc aggaattatg gaaatgtttc atgaatatgg
     5041 gattgacttg gaaggtaaaa atgcggtcgt catcggtcgt tcaaatatcg ttggaaaacc
     5101 tatggctcag cttcttttgg ctaaaaatgc gacagtaacc ttgacccact cacgaactca
     5161 taatcttgcc aaggtggctg ctaaagcaga tattcttgta gtcgcaatcg gccgcgccaa
     5221 gtttgtgact gctgactttg tcaaaccagg tgcggttgtc attgacgttg ggatgaaccg
     5281 agatgaaaat gggaagctct gtggagatgt tgattatgag gcagttgcac cacttgctag
     5341 ctatatcacg ccagtccctg gaggtgtcgg tcctatgacc attaccatgc tgatggagca
     5401 aacttatcaa gcagcacttc ggacattgga tagaaaataa gagaaacatt cgattaatag
     5461 agtgtatttt ctatagctat atctaaaatg gcagaaatga atattaaatt ttagatataa
     5521 gattacaaaa ggaggtctgc gtctcctttt tattgtataa taaaagtgag aggaaaaaag
     5581 gatgaaagtg attaatcaaa ccttattaga aaaagttatt attgaacgtt ctcgttcaag
     5641 tcataaagga gattatggtc gtctgctgct gcttggtggt acttatcctt atggaggtgc
     5701 catcatcatg gctgctttag cagctgtaaa aagcggtgca ggattggtga ccgttggaac
     5761 ggacagggaa aatatcccgg ctctgcacag ccatttacct gagcctatgg ccttttctct
     5821 tcaagaccag caattgttaa aagagcaatt ggagaaggca gaagttgtct tgttggggcc
     5881 tggtttacga gacgatgctt ctggagaaaa tctagtaaaa caggtctttg ttaatttaag
     5941 ccaaaatcag attttgattg tagacggagg tgccttgacc attcttgcta ggacaagttt
     6001 gtcatttccc tcaagccagc ttatcctaac tcctcaccaa aaagaatggg aaaaattatc
     6061 tggaattacg attgaaaagc aaaaggaaga tgcaacggct agtgttctga cttccttccc
     6121 tcaaggaaca attttggtgg agaaaggccc agctactcgt atttgggaag ttggccaatc
     6181 tgattattac cagttacagg ttggtggtcc ttatcaggcg actgggggaa tgggagatac
     6241 tctggctggg atgatcgcag gatttgtagg ccaattccga caggccagtc tctacgagcg
     6301 tgtggcagta gcgacccatc ttcattcagc catagcccaa gaactatctc aagaaaatta
     6361 tgtggtctta ccgacggaaa tcagcaggta tcttcccaaa ataatgaaaa ttatttgtca
     6421 acaagagagg gtaagcaaag ataaacttgt ttaaaataga cagataaatc tacttccttc
     6481 tcttaattta tgattcttga aatgcgcctg ctttaaggct aaactagacg tatcaaagtt
     6541 aagagtttgt ttttgtaact ggaaagagat gaacaaatca aatacataaa agataaactc
     6601 atttttattc gtttggtaaa aataaaatgc atatttttaa agaaagattg atgaaaaatg
     6661 tagatttgat gtttttactt gaataaaaag cggtttcata gtaaaataag aactgagaat
     6721 gatggaggta aatcggtgga aaatctgaag aaaatggcag gtatcaaggc tgctgagttc
     6781 gtgagcgatg gaatggtcgt tggacttgga acaggctcga ctgcctatta ttttgtcgaa
     6841 gaaatcggtc gtcgtatcaa ggaagaagga ttgcagatta cagctgtaac aacttctagt
     6901 gtgaccacta aacaggcaga aggccttaat atcccgctca agtctattga ccaagtagac
     6961 tttgtcgatg tgacggttga tggcgcggat gaagtggata gtcagtttaa tggaatcaaa
     7021 ggcggtggtg gtgcccttct catggaaaag gtggtcgcaa caccatcaaa agaatacatt
     7081 tgggtggtgg atgaaagcaa gctggtcgaa aaactaggtg cttttaaatt gccagtagaa
     7141 gtggttcagt atggtgcaga gcaggtcttt cgtcattttg aacgagctgg ctacaaacca
     7201 agtttccgtg aaaaagacgg ccaacgtttt gtgacggata tgcagaattt tatcattgac
     7261 ctcgccttgg atgtcattga aaatccaatt gcttttggac aagaattgga ccatgtcgtt
     7321 ggtgttgtgg agcatggttt attcaaccaa atggtggata aggtaatcgt tgctggacga
     7381 gatggagttc agatttcaac ttcaaaaaaa ggaaaataga agggggcata agatgtctaa
     7441 atttaatcgt attcatttgg tggtactgga ttctgtagga atcggtgcag caccagatgc
     7501 taataacttt gtcaatgcag gggttccaga tggagcttct gacacactgg gacacatttc
     7561 aaaaacagtt ggtttgaatg tcccaaacat ggctaaaata ggtcttggaa atattcctcg
     7621 tgaaactcct cttaagactg tagcagctga aatcaatcca actggatatg caacaaaatt
     7681 agaggaagta tctcttggta aggatactat gactggacac tgggaaatca tgggactcaa
     7741 cattactgag cctttcgata ctttctggaa cggattccca gaagaaatcc tgacaaaaat
     7801 cgaagaattc tcaggacgca aggttattcg tgaagccaac aaaccttatt caggaacggc
     7861 tgttatcgat gattttggac cacgtcagat ggaaactgga gagttgatta tctatacttc
     7921 agctgaccct gttttgcaga ttgctgccca cgaagacatt attcctttgg atgaattgta
     7981 ccgtatctgt gaatacgctc gttcgattac ccttgagcgt cctgcccttc ttggtcgcat
     8041 cattgctcgc ccttatgtag gtgaaccagg taacttcact cgtacggcaa accgtcgtga
     8101 cttggctgta tctccatttt ccccaactgt tttggataaa ttgaatgagg ctggtatcga
     8161 tacttatgct gtgggtaaaa tcaacgatat ctttaacggt gctggtatca accatgacat
     8221 gggtcacaac aagtcaaata gtcatggaat tgatacacta ttgaagacta tgggacttgc
     8281 tgagtttgaa aaaggattct cattcacaaa cctagttgac tttgatgccc tttacggcca
     8341 tcgtcgtaat gctcacggtt accgtgattg tttgcatgag tttgatgaac gcttacctga
     8401 aattatcgca gctatgagag agaatgacct tctcttgatt actgcggacc atggaaatga
     8461 cccaacgtat gcagggacgg atcacactcg ggaatatatt ccattgttgg catatagccc
     8521 tgcctttaaa ggaaatggtc tcattccagt aggacatttt gcagatattt cagcgactgt
     8581 tgccgataac tttggtgtgg aaactgctat gattggggaa agtttcttag ataaattggt
     8641 ataagatgac gcgctatgct ttgctggtga gaggtatcaa tgttggtagt aagaataagg
     8701 tcgttatggc ggagcttcgt caagaattga caaacttggg actggaaaag gttgagagct
     8761 acatcaacag tggcaatatt ttctttactt cgatagattc caaagcccaa ttggtttaaa
     8821 agctagagac tttctttgca gtccattatc catttattca gagcttttct ttactgagtc
     8881 tagaggactt tgaggcggaa cttgaaaatc taccagcttg gtggagcaga gacttggcac
     8941 gaaaagattt tctcttttac actgagggtt tggatgtgga ccaagtcatc gcgacagttg
     9001 aaagtttaga gctgaaagat gaagtgcttt attttagaaa acttgggatt ttctggggga
     9061 aattttctga agaatcctat tctaagactg cctatcataa gtacttgctg aaggtgcctt
     9121 tctaccgcca cattactatt cgtaatgcta aaacctttga caaaattggt caaatgctaa
     9181 aaaataataa aggagacaca taatgacatt tttaaacaaa atccatgaaa ctgctacttt
     9241 cctgaaagaa aagggaattg cagcccctga gttcggtcta atccttgggt caggacttgg
     9301 agaattggca gaagaaatcg aaaatccagt tgtagtagac tatgctgaga ttccaaactg
     9361 gggccgttca acagtagtcg gtcatgctgg taaattggta tatggtgaac tggcaggtcg
     9421 caaggtcttg gctcttcaag gtcgtttcca tttctatgaa gggaatcctc tggaagtggt
     9481 gactttccca gttcgtgtga tgaaagttct tggatgtgaa ggtgttattg taaccaatgc
     9541 agctggcggt atcggatttg gtcctggtac cttgatggct atctcagacc atatcaacat
     9601 gacggggcaa aatccattga tgggtgaaaa cttggatgac tttggcccac gtttcccaga
     9661 tatgtctagg gcctacacac cagaataccg tgccactgcc catgaagtgg ctaaaaaact
     9721 taatatcaag cttgatgaag gtgtctatat cggagttact ggtccgactt atgaaacacc
     9781 agcagaaatt cgttcctata agacactggg agcagatgca gttggtatgt ctacggttcc
     9841 tgaagttatc gtggcagccc actctggctt gaaagttcta ggaatttcat gtatcactaa
     9901 ctttgcggct ggtttccaag aagaactcaa tcacgaagaa gttgtagaag tgactgaacg
     9961 tgttaaaggt gatttcaaag gcttgcttaa agcgattctt gctgaattgt aagaaaaaag
    10021 atttaaaagg ggaagtacct ctgttttttc aggattgact gcctatccgg attaaagaag
    10081 aaacagagga atactatgag cttcttcctg ctcttataac tgaaagaagc ggaagaatag
    10141 gtatgtctga tctgatagcc agcattgtga aagacaagat tctaggatac tagcattagc
    10201 ttcctagcca agcagactag tatgataagg agagatgaga atgaattgac tttctgaatt
    10261 tctcagtctt atcatatata gcacaatgag atttcgcttg agtctgcttg taaataaacg
    10321 aaaagaaaga taagaaataa tgaaaattgg tcaacgaatt atgcgctttg gcataaaaaa
    10381 ttaagtatcg gagttgtatc tgttgtagtc ggctttgatt tctagctcca gctggaattt
    10441 cagccaatga agtaaagtaa gatgtaacat ctgaagtggt aataggtgtg ttagattcta
    10501 aggaggaatt gaaagagtca gaaaatgatg ctctaaaact agaaactcct cttagagagg
    10561 agccaagact agctcctcaa acgcttccgg aagcaagtga agttagttct tgaaaacaaa
    10621 agggaagagt caaaagtaga gataacagaa ccagctcaag cggatgatat ccgcaaggtt
    10681 gttggggaat tagccaagga tataagtatt actaagttgt atatgacagg tcattttctt
    10741 ggatgttacc tagctcagat tgcagcggtt gaagcttacc aaaaatatcc tgatttttat
    10801 aaccatgtat tgaggagagt gacaactttc agtgctccta aagtgattac ttccagaact
    10861 gtttggaatg ctaagaatgg tttctgggat gttggtttgg aaagtcgtaa attagctgtt
    10921 agtggaaaaa ttaagcatta tgtggttgat aatgacaatg ttgtgactcc cttgattcat
    10981 aatgatcgtg atattgttac atttacaggt aattcacgct ttaaacaccg ttctcgtggc
    11041 tattttgaaa gtccaatgaa tgatattcct aactttaata ttggtaaaca agctaccttt
    11101 gataaacatg gttatcgtga tccgaaattg gataaagtgc gattctttaa gaaacaggct
    11161 ctacctcaat cttctagtca accaagcgct gaaccaatgg aaaatattgc cttaggaaaa
    11221 caggttactc aaagttcgac agctttcgga ggagatgcta gaagagctgt ggatggcaaa
    11281 gtcgatggta actatggtca caattctgtc actcatacaa acttccaatc taagccttgg
    11341 tggcaagtag atttggctaa agaagaaacc attcgccaaa tcaatattta caaccgaaca
    11401 gacactgccc aggatagatt ggcaaacttt gatgtcattc ttttagacag ttctggtaaa
    11461 gaaattgagt gaaaacgtat aacatctcct aaagatgtgt cagcacaaat tacgattaac
    11521 cataaaaaaa gcgcgctatg ttcggattga gctagaaggc tataatgccc tcagtcttgc
    11581 agaagttgaa gttttccgct ttatagctac gaatggtgaa acggcgatac aagtttctaa
    11641 gtcagttcaa ccaatcagtc agactcctgt gaaagataaa acattgacaa ttcaacacag
    11701 tggagcttac attgcccgct actccataac ttgggaagaa gttacagtag ataaagatgg
    11761 aaaccaagtt gttcgtagtc attcttggga aggaaacggt cgcaaccaga ctgcaggttt
    11821 tgtcctcaac ctcccaatca aagaaaatat gagaaatctg cgagttaaga ttgagaaaaa
    11881 gacgggccta ctatggaata gatggcaaac aatctatgaa aacagaccaa ttttagctca
    11941 accccaccgt aaaattaccc attggggtac gacattgaat tccaaggtga gtgacgatga
    12001 tgtcttgtaa tctgatggta gaatgacagt tagtttgtct agtttataag aaagtactac
    12061 ctgagcttga atagaactca ggtagctctc tatgaaagaa caaaattaat actcaatgaa
    12121 aatcaaagag caaactagga aactagccgc aggttgctca aagcactact ttgaggttgt
    12181 agataagact gacgaagtca gtcacatata taatccaagg cgacgttgac gtggtttgaa
    12241 gagattttag aagagtataa acagaaaggt agagcgcgtg ttctaatttg aacacgagta
    12301 gaaaactttt ctaaaaacaa aaacgaaagg atgggtaaac tgtattcgct gaactgaata
    12361 cgggcgactc tcctctaaat caaaattaag aaaggaattg accccaccct aaaagtagtg
    12421 ggaaaaagat agttggtcta gcgagcatcg ctcactgcgc ccaactccta ttttcccttc
    12481 gctttttgat gggtttggta tctttctcaa tataaaatat aaaataaaga aaggtagagc
    12541 gcgtgttcta atttgaacac gagcggaaaa ctcggaaaat agataatctg actgaaaaat
    12601 caggatttct cgtcaggttc ctaattttca gtcgttttct tctcgctctt tgtatcataa
    12661 attatgtcta tccatattgc tgctcagcag ggtgaaattg ctgataaaat tcttcttcct
    12721 ggggatcctc ttcgtgctaa gtttattgcg gagaatttcc ttgatgatgc tgtttgtttt
    12781 aacgaagtgc gtaacatgtt tggttacact ggtacttaca agggtcactg tgtatctgtc
    12841 atgggaactg ggatgggaat gccatctatt tcgatttatg cgcgtgagtt aatcgtagac
    12901 tacggtgtga agaaattgat tcgtgtggga actgcaggtt ctttgaatga agaggttcat
    12961 gttcgtgaat tagttttggc gcaggcggct gcaaccaact caaacatcgt tcgtaatgac
    13021 tggccacagt acgattttcc acaaattgct agctttgatt tgcttgataa agcctaccat
    13081 atcgccaaaa aatttggtat gactactcac gttgggaacg ttttgtcatc tgatgtcttt
    13141 tactcaaatt actttgaaaa gaatatcgag cttggtaaat ggggagtcaa ggctgtggaa
    13201 atggaagcag cagctcttta ctatcttgct gcccaatacc atgttgatgc gctagctatc
    13261 atgaccatct ctgatagctt ggtcaatcca gacgaagaca caactgcaga agaacgtcaa
    13321 aataccttca ctgatatgat gaaggttggt ttggaaacct tgattgcaga ataattatag
    13381 ccaaaaagga agccctttat gaattgtagg acttcctttt cttatccaga aattgatcta
    13441 gttctctctg atttcgaaga atagtgactt tatgtgaata ttcttggcaa agtttttggt
    13501 aattttcttt ttgagttttg ctacgcccat cccaaagaat ccatctgata aactcccact
    13561 caaagcgttc agggcaatct gccgccatac tttctctgac ttttccacgg tatttaagat
    13621 aacgcttaaa ggctctaaag agacaggtca atggcaaaaa attgagaaag atgatttggt
    13681 cagcttcttg cattcgttct tggtagtagc accaagaata attaccatcg atgacccaag
    13741 ctttatgctt ggtgagaaag ttttttatct cggttaacat ccattcgcag tcactgtctt
    13801 gccaaccagg ttgaaattgg agtgtgtcca tgtgcagttt tggaatggag tagtagttag
    13861 ataacttttc tgctagagtt gacttaccag aaccagaata tccgataatt gtgattttca
    13921 ttttctacct tttcctattt ggagacaaaa aaacagcctc tatggactgt ttcttattta
    13981 gcaagtttag ctgaaagacg agctttatcg cggcttgctt tgtttttgtg aatcaaacct
    14041 ttagtttctg ctttatcgat agctgagcta gcagcacgga aaagttcttc agatgggttt
    14101 gcttcaaaag cttttatagc agtacgcata gctgattttt gagctgagtt cttttcgttt
    14161 tgtttaacgt tcaattcagc gcgtttgata gctgatttaa tgtttgccaa tgttcttacc
    14221 tccatattta ctaactatac cattatatat gaaaacttac gttttgacaa gggaaaatta
    14281 tttttttaag taaatttcat cgatttcatg gttcttgctt ttatgaagaa tcacttctgc
    14341 acgatttctg gttggttcaa tataattttg tagatttgtg agattgatac tggtccagac
    14401 ctgatgggca aaggcttcca cttccccaat cggcatctga gtaaaacgat aatagtagct
    14461 atcagggtcg ttttgggcta gactcagcat tttcaagaaa cggtccagat accaactttc
    14521 aatatcatcc actccagcat ctacatagat ggaaaagtca aagaagtcag tgatatagag
    14581 acgatcgttt tgtggatttt gaaagacatt gattccctca acaattacaa aatcagcagc
    14641 tttgacactt tgtttctctt cgggtacgat gtcgtaaact tcatgagaat agacaggaat
    14701 atctacatct tgtccatttt tgatgcggtc caagaagttg agaagagctt ccatatcata
    14761 gctttcagga aatcctttac gatttaaaat cccctgctca atcaaggttt gattgggata
    14821 gagaaaacca tcagttgtaa ccaactcaac cgtagcatct gtaaacgtac gggacagtag
    14881 gatttgaagt aggcgactgg ttgtggattt tccaacggca acactcccag aaaccccaat
    14941 aataaaaggt tgagatttac tttcacgttg gaggaaaatt ccttttgaaa aggctaaatc
    15001 ttccttagtt cgcttgtaaa tctgaatcag atgagccaag gggagataga tatctgtaac
    15061 gtcttggaga ctgatttggt cattaaaact cttgatagat tccaattctt cttctgtcaa
    15121 aggaggtgtt gtctttcgat gtaaagattg ccaagtctgg cggctgattt tttcaaaatg
    15181 taaaaattcg ttggtcattt gttttcccct agatattttg tctatcatac cataaaaatc
    15241 taaaaaaata aagcggtttc ttgaatgtgg taagtcaatg gtatatagta taagtgatca
    15301 atttattgat gaaataggag atagattcta ctgatttata agtttataag cttataaagg
    15361 gggcttttta gttcacaact tataggaggt gtactatgaa aatcttaaaa cgttacatat
    15421 tggaactctg ttttatttta agttttgctt taccttttat aaaaggagcc aatgcagata
    15481 atggtatatg ctttgtggaa acctattacg gttttacttt tttgatggaa catgctattg
    15541 taacagctgt ctttatctat tcgttttcaa ttgctttctt actaaaaaaa cgatgggcga
    15601 aatggattgc tgctggtagt tattgctttt tagtcctatg gattgcgaca gagggttatt
    15661 tcttccgcat gtcactagaa gatttgatac gactttggac aagtttggaa atcctgacac
    15721 aaacgtatca gttgggcttt tatctaaaca ttttgttggg aattttgttg ataataaagt
    15781 attttaaggt taagcaatag aaataataat ctgcctgatt atagatgata aactttttgt
    15841 ttttatctgg actgtgatat ttatagttct aaatggttta ttatttataa gtgttgaaag
    15901 agattgaaga aaatggcttc gtgactcgct ttcttcggtc tttttcgttt tattatcaat
    15961 ttgtaaacga tttacaattt gagtcaaatt atggtaaaat agtgtcatga gtaaaatgta
    16021 ttatgcagaa aatcctgacg ctgctcacga cattcatgag ttgagagtag agttgttggg
    16081 acaaaaaatg acctttttaa cggatgcggg tgtttttagc aagaaaatag ttgactttgg
    16141 aagtcaacta ttgctcaagt gtcttgaggt caaccaagga gaaactgtcc ttgatgtagg
    16201 ctgtggttac ggacctttgg gtttgtcctt agctaaggct tatggagttc aggctactat
    16261 ggttgatatc aacactcgtg ccttagattt agctcggaga aatgctgaaa aaaataatgc
    16321 aaaagcgacg attttccagt ccaacatcta tgaacaagtt gaaggacatt ttgatcatgt
    16381 catttccaat cctcctatcc gtgcgggcaa gcaagtcgtt catgaaatca ttgagaaaag
    16441 taaagatttc ttggaaactg gtggggattt gacaatcgtc atccagaaaa aacaaggggc
    16501 tccaagtgct aagtccaaga tggaggatgt gtttggtaat tgtgaaatcc ttaaaaaaga
    16561 caaaggatac tatatcctta gaagtgtgaa agaatgagag cagttgattt aatacaaaaa
    16621 aaacgagacg gtcaagaact gacttcaagt gaaattgaat ggctggtaga aggctatgtg
    16681 tcaggaactg ttcctgatta tcagatgtct gcctttgcta tggctgttta ttttaaagga
    16741 atgacgactc gtgaaatttc tgatttaacg atgaatatgg ttaagactgg gcaagagttt
    16801 gacctgtcag ccattgatgg tgtgaaagtt gacaagcatt ctactggtgg tgtcggcgat
    16861 aaggtaacct tgattttagc tcctcttgtt gctagcttcg gtgtgcctgt agcaaaaatg
    16921 agtggtcgtg gtcttggcca tacaggcgga acaattgata aattggagtc cattaggggc
    16981 tatcaagtag aacgtagtca agaggatttt attcgtcagg ttcaggatat tggagtatct
    17041 gtcattgggc aatcagacca gctggtcaaa gcagataagc ttctctatgc ccttcgtgat
    17101 gtgaccgcaa ctgtcgacac gattcctttg attgcgagtt cggtgatgag caagaaaatc
    17161 gcggcagggg cggatgctat tttgctagac gtgactgtcg gtgagggtgc cttcatgaag
    17221 acggttgatg aggcgcgtga gttggctcaa actatggtag atcttggtaa ggttgttgga
    17281 cggaagacag tagcagtgat tacggatatg agccagcctt tgggacgagc gattggaaat
    17341 cgtctggaaa tccttgaagc attggagatt ttgcaaggtc aaggacgtca ggatattacc
    17401 cactttattt gtgaattggc tcaaattatg cttggcttgg caaatgttaa caagactgtt
    17461 gaagaagttc gccaacatct tgaggatggt caagcactgg ctaagtttga ggaaatggtg
    17521 caagcccaag gtggagactt ggaagacctc tatcgtcctg taaatgtagc tcatgtggtg
    17581 gaaatccctg ctcaggaaac aggtgtcatt tcagctcttc cagctatgga ctttggtctt
    17641 tatgccatga ggctgggtgc tggtcgtgca gttaagtctg atgccttgga ctatgaaaca
    17701 ggaattgttt ttgaaaagaa gattggagac tccgttcaaa agggtgaaat tgttgcaaaa
    17761 gtatacacaa atgaaaaaat tccacctcaa ctagttacag atttccaaaa atgtgttaaa
    17821 ataagtgatg aagtgaaaaa aatccgtgaa attgtagaaa tcatctccta aatggaggga
    17881 aaaccgaaat gaaattaaat aaatatatag atcatacgct tttaaaacaa gatgcaaaga
    17941 aaaaacaaat tgatagtttg ttgtctgagg ctagagagta tggctttgcc agtgtttgcg
    18001 ttaatccaac ctgggttgaa catgctaaaa aagggcttga aggcacagat gttaaggttt
    18061 gcacggtagt aggtttccct ttgggagcaa caacttcagc cgtgaaagca tttgagacaa
    18121 aagaagctat ccaaaatggt gcagatgaga ttgatatggt gatcaatgtt ggagctctca
    18181 aatcaggtaa tttagccttg gttgagtcag atattcgcgc agtagtggaa gcaagtggtg
    18241 ataagttagt gaaagtcatt attgaagctt gccttctgac agaccaagaa aaagttgttg
    18301 tttgccaatt ggcccaaaaa gctggggctg actttgtcaa aacatctact ggcttttcaa
    18361 ctggtggtgc tacgatagca gatgttacat taatgcgtga aacagttgga tctgatatgg
    18421 gagtcaaggc tgctggtgga gctcgttctt atgcagatgc tcttgccttt gtcgaagcag
    18481 gtgcgacccg tatcggaacg tcagctgggg tagctatttt aaaaggagaa ttggcagatg
    18541 gcgactactg agttgattga actggcaatt gaaaccagca aacatgccta tgtcccctat
    18601 tctcactttc ctatcggagc agttttagta gccaaagacg gaaatgttta cacgggagtg
    18661 aatatcgaaa atgctagcta tcctttgacc aattgcggtg agagaacagc tatttttaag
    18721 gctatatctg aaggccaaag agaattttca gaattgattg tctatggtca aactgaaaaa
    18781 ccgatttcac catgtggtgc ttgtcgccaa gtaatggtcg aattttttga acaagattta
    18841 aaagtgacct tagtcgcaaa agataaatcg acggtcgaga tgacggtcgg ggagttactt
    18901 ccatattctt ttacagactt aaattagtct gagtcgctct ttgagtggca agggtctttg
    18961 tgaccaatca atccatactt gcaacatcgt tgcacatctt atttaggagg ttcagtaatg
    19021 aacaagaaac aatggctagg tcttggccta gttgcagtgg cagcagttgg acttgctgca
    19081 tgtggtaacc gctcttctcg taacgcagct tcatcttctg atgtgaagac aaaagcagca
    19141 atcgtcactg atactggtgg tgttgatgac aaatcattca accaatcagc ttgggaaggt
    19201 ttgcaggctt ggggtaaaga acacaatctt tcaaaagata acggtttcac ttacttccaa
    19261 tcaacaagtg aagctgacta cgctaacaac ttgcaacaag cggctggaag ttacaaccta
    19321 atctttggtg ttggttttgc ccttcacaat gcagttgaag aagcagctaa agaacacact
    19381 gacttgaact atgtcttgat tgatgatgtg attaaagacc aaaagaatgt tgcgagcgta
    19441 actttcgctg ataatgagtc aggttacctt gcaggtgtgg ctgcagcaaa aacaactaag
    19501 acaaaacaag ttggttttgt aggtggtatc gaatctgaag ttatctctcg ttttgaagca
    19561 ggattcaagg ctggtgttgc gtcagtagac ccatctatca aagtccaagt tgactacgct
    19621 ggttcatttg gtgatgcggc taaaggtaaa acaattgcag ccgcacaata cgcagccggt
    19681 gcagatattg tttaccaagt agctggtggt acaggtgcag gtgtctttgc agaggcaaaa
    19741 tctctcaacg aaagccgtcc tgaaaatgaa aaagtttggg ttatcggtgt tgaccgtgac
    19801 caagaagcag aaggtaaata cacttctaaa gatggcaaag aatcaaactt tgttcttgta
    19861 tctactttga aacaagttgg tacaactgta aaagatattt ctaacaaggc agaaaaagga
    19921 gaattccctg gcggtcaagt gatcgtttac tcattgaagg ataaaggggt tgacttggca
    19981 gtaacaaacc tttcagaaga aggtaaaaaa gctgtcgaag atgcaaaagc taaaatcctt
    20041 gatggaagcg taaaagttcc tgaaaaataa tggatggaag tcatttctta ggaagcggcc
    20101 aagggccgct tttttaagag ttgagacaaa gtcattttgt ctcagtaaag cttgctacta
    20161 gacaaactag caagttttat tgaaataaaa taagactctg aaaggaagag cacatggcac
    20221 acgaaaatgt cattgagatg cgtgatatta ccaaggtgtt tggtggattt attgccaacg
    20281 acaaaatcaa cttgcaccta cgaaaaggtg aaattcatgc acttttagga gaaaatgggg
    20341 ctggtaagtc cacgctaatg aacatgttag caggccttct tgaaccaact agtggtgaaa
    20401 tcgcggtcaa cggtcaagtt gtcaatctcg actccccatc taaagcagct agcttgggaa
    20461 tcgggatggt tcaccagcac tttatgttgg ttgaagcctt cacagtggct gaaaacatca
    20521 ttttaggtag tgaattgact aaaaatggtg tgctagatat cgctggagct agcaaagaaa
    20581 tcaaggctct ttctgaacgt tatggcttag ctgttgaccc ttctgccaag gtagcagata
    20641 tctcagttgg agcccaacaa cgtgtagaaa ttttaaaaac actttatagg ggggctgata
    20701 tccttatctt tgacgaacca acggctgttt tgactccatc agaaattgat gagttgatgg
    20761 ctattatgaa aaatcttgtc aaagaaggaa aatcaattat cttgattacc cacaaattgg
    20821 atgaaattcg cgcagtttct gaccgtgtta cagttatcca tcgtgggaaa tcaattgaaa
    20881 ccgttgaaat tgcaggggct accaatgctg atttggcgga aatgatggta ggacgttctg
    20941 tttcctttaa aacagagaag caagcctcta aaccaaaaga agtggttttg tctatcaaag
    21001 atttggtggt caatgaaaac cgtggtgttc cagctgttaa aaatctgtcc ttggatgttc
    21061 gtgctggaga gattgttggt attgcgggga ttgatggaaa tggtcagtct gaactgattc
    21121 aagccattac aggtcttcgt aaggttgaat ctggtagcat tgagctaaaa ggagattcaa
    21181 ttgtaggctt gcacccacgt cagattacag aactaagtgt tgggcacgtt ccagaagacc
    21241 gtcaccgtga tggcttgatt ttggaaatga tgatatctga aaatattgcc cttcaaacct
    21301 actataaaga accacatagt aaaaatggaa ttttgaacta ttcaaatatt acttcttatg
    21361 ctaaaaagct gatggaagag tttgatgttc gcgctgccag tgaattagtt cctgcagctg
    21421 cactctcagg aggaaatcaa caaaaagcaa ttattgctcg tgaaattgat cgagatcctg
    21481 atctccttat cgttagccag ccaactcgtg ggttggatgt cggtgccatt gagtatatcc
    21541 acaaacgctt gattgaagag cgtgataatg gcaaggctgt ccttgttgtc agctttgaat
    21601 tggatgagat tttaaacgtc tcagaccgta ttgccgttat ccacgatggt aagattcaag
    21661 gtattgtatc accagaaaca accaataaac aagaacttgg tgtcttgatg gctggtggaa
    21721 acttgggaaa ggagaagagt gatgtctaaa aaattacaac aaatttcggt tcccttgatt
    21781 tctgtatttc taggaatttt actcggagcc attgtcatgt ggatcttcgg ttatgatgct
    21841 atttggggct acgaagaatt attctataca gcctttggca gtctgcgtgg gattggagaa
    21901 atcttccgtg ctatgggtcc tctggtcttg attggtcttg gttttgcggt tgccagtcga
    21961 gctggtttct ttaacgtcgg acttcctggt caggctttgg caggttggat tctcagtggt
    22021 tggtttgcgc tgtcgcatcc agatatgccc cgtcccttga tgattctagc aaccatcgtg
    22081 attgccttga ttgctggtgg gattgtcgga gcgattccag gtattcttag ggcctatcta
    22141 gggacgtcag aggttattgt aaccatcatg atgaactaca ttgtcttgta tgtagggaat
    22201 gcctttatcc atgctttccc taaagacttc atgcaaagta cagattcgac cattcgtgtt
    22261 ggggctaatg caacctatca gacaccttgg ttggctgagt tgactggtaa ctcacggatg
    22321 aatattggta ttttctttgc catcattgcc gttgcagtta tttggttcat gctcaagaaa
    22381 acaactcttg gttttgaaat ccgtgcagtt ggtcttaatc cacatgcttc agaatatgct
    22441 ggtatttctg ccaagcggac tattatccta tctatgatta tttcaggtgc cttggcaggt
    22501 cttggtggag ctgttgaagg tttgggaacc ttccagaacg tctatgttca aggttcgtca
    22561 ttagctatcg gatttaacgg aatggcggtt agtttgcttg cggccaactc accaattggt
    22621 atactctttg cagccttcct atttggcgtt ctccaagttg gggctcctgg tatgaatgcg
    22681 gcgcaggtac catctgagct tgtcagcatt gtaacagcgt ctattatctt ctttgtcagt
    22741 gttcattacc ttatcgaacg ctttgtcaaa ccgaaaaaac aagttaaagg aggtaagtaa
    22801 agatgtctat tataaccttg ctccccctct tggtgtcttc tatgctgatt tactcagcac
    22861 ctctcatctt tacaagtatc ggtggtgttt tctctgaacg tggtggtgtg gtaaacgttg
    22921 gccttgaagg aattatggtt atgggtgcct tttctggagt tgtctttaac cttgaatttg
    22981 cagaacaatt tggagcagca actccatggc tatccttgct tgtagcagga ttggttggta
    23041 gtgttttctc tatcatccac gcagcagcga cggttcattt ccgtgcagac catgttgtca
    23101 gcggtacggt attgaacttg atggcgcctg ccttggctgt tttcttagtt aaagttcttt
    23161 ataacaaagg acaaaccgac aacctaagtc aaacttttgg acgctttgat ttcccagtct
    23221 tggcaaatat cccagtgatt ggtgatatct ttttcaagtc aactagtcta cttggttatc
    23281 tggcgattgc cttctcattc cttgcttggt ttattctctt taagactcaa tttggtcttc
    23341 gtctccgctc tgtcggtgaa catcctcaag cagcggatac cttgggaatc aacgtctaca
    23401 agatgagata tttagggatt attatttcag gttttctagg tggaattggc ggagcgattt
    23461 atgcgcaatc aatctcagtt aacttctcag tgacaactat tgttggacct ggatttatcg
    23521 cccttgctgc gatgatcttt gggaaatgga atccaatcgg tgctatgctt tctagtctct
    23581 tctttggact ttcacaaagt ttggctgtta tcggttctca attgccgttc ctacaaggag
    23641 tgccagcggt ttatcttcaa attgcacctt atgttttgac aattcttgtc ttagcagcct
    23701 tctttggaaa agcagtcgca ccaaaagcag atggtatcaa ctacatcaaa tcaaaataag
    23761 catacaaaaa aacgtcagtc caatgactga actgcccccc aaaagttaga cagaaaaaat
    23821 ctaacttttg gggtgttttt attatgaaat taagttatga tgataaagtt cagatctatg
    23881 aactaagaaa gcaaggatat agcttagaga agctttcaaa taaatttggg ataaataatt
    23941 ctaatcttag gta
//
LOCUS       DAVLHC010000030        23935 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.030, whole genome shotgun sequence.
ACCESSION   DAVLHC010000030 DAVLHC010000000
VERSION     DAVLHC010000030.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 23935)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 23935)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..23935
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.030"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(158..376)
                     /locus_tag="VXE25_001383"
     CDS             complement(158..376)
                     /locus_tag="VXE25_001383"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001207345.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEV0771836.1"
                     /translation="MALNYKPLWIQLAKKGLKKTDVIAMAGLTTNVMAQMGKDKPITF
                     KNLERICKALSCTPNDIISFEDNFSDEE"
     gene            complement(622..900)
                     /locus_tag="VXE25_001384"
     CDS             complement(622..900)
                     /locus_tag="VXE25_001384"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000710796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771837.1"
                     /translation="MKKDKEVYDKVCEYLSPHLNKDMEVLELACWFRVIIVIEANSYV
                     NIRSSRLLPKFKTQKINSWCAVYSIHFNNGYCKQHTNEFKDSLKSLIL"
     gene            complement(1114..2745)
                     /gene="rlmD"
                     /locus_tag="VXE25_001385"
     CDS             complement(1114..2745)
                     /gene="rlmD"
                     /locus_tag="VXE25_001385"
                     /EC_number="2.1.1.190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000914584.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="HEV0771838.1"
                     /translation="MLKKNDIVEVEIVDLTHEGAGVAKVDGLVFFVENALPSEKILMR
                     VLKVNKKIGFGKVEKYLVQSPHRNQDLDLAYLRSGIADLGHLSYPEQLKFKTKQVKDS
                     LYKIAGIADVEVAETLGMEHPVKYRNKAQVPVRRVNGVLETGFFRKNSHNLMPLEDFF
                     IQDPVIDQVVVALRDLLRRFDLKPYDEKEQSGLIRNLVVRRGHYSGQIMVVLVTTRPK
                     VFRVDQLIEQVIKQFPEIVSVMQNINDQNTNAIFGKEWRTLYGQDYITDQMLGNDFQI
                     AGPAFYQVNTEMAEKLYQTAIDFAELKKDDVVIDAYSGIGTIGLSVAKHVKEVYGVEL
                     IPEAVENSKKNAQLNNISNAHYVCDTAENAMKNWLKDGIQPTVILVDPPRKGLTESFI
                     KASAQTGADRIAYISCNVATMARDIKLYQELGYELKKVQPVDLFPQTHHVETVALLSK
                     LDVDKHISVEIELDEMNLTSAESKATYAQIKEYVWNKFELKVSTLYIAQIKKKCGIEL
                     REHYNKSKKDKQIIPQCTPEKEEAIMDALRHFKMI"
     gene            complement(2819..3793)
                     /locus_tag="VXE25_001386"
     CDS             complement(2819..3793)
                     /locus_tag="VXE25_001386"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1002 domain-containing protein"
                     /protein_id="HEV0771839.1"
                     /translation="MRKKLFLTSAAILWAVTAMNSVHAATDVQKVIDETYVQPEYVLG
                     SSLSEDQKNQTLKKLGYNASTDTKELKTMTPDVYSKIMNVANDSSLQLYSSAKIQKLG
                     DKSPLEVKIETPENITKVTQDMYRNAAVTLGVEHAKITVAAPIPVTGESALAGIYYSL
                     EANGAKVPQANKDLAQEELKALSDINAENKDKSGYDANKLNVALADIKSGLAKAKESK
                     GNLTEEDIRKIVEDTLKNYKLDQVITGNQINIIINFALNLSKSDILSNADFTKTLNDL
                     KQSIVSQAGDSFKNINLNFDADKALEDGGNFLSSLWQALVNFFKSFGS"
     gene            complement(3867..4481)
                     /gene="pmp23"
                     /locus_tag="VXE25_001387"
     CDS             complement(3867..4481)
                     /gene="pmp23"
                     /locus_tag="VXE25_001387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000476388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall hydrolase Pmp23"
                     /protein_id="HEV0771840.1"
                     /translation="MFKRIRRVLVLAVFLFAGYKAYRVHQDVKQVMTYQPMVREILSE
                     QDTPANEELVLAMIYTETKGKEGDVMQSSESASGSTNTINDNASSIRQGIQTLTGNLY
                     LAQKKGVDIWTAVQAYNFGPAYIDFIAQNGKENTLALAKQYSRETVAPLLGNTTGKTY
                     SYIHPISIFHGAELYVNGGNYYYSRQVRLNLYIIKCFTLFSTSG"
     gene            complement(4481..5455)
                     /locus_tag="VXE25_001388"
     CDS             complement(4481..5455)
                     /locus_tag="VXE25_001388"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoid-associated protein"
                     /protein_id="HEV0771841.1"
                     /translation="MDIYIKKAIIHQFSPDDTELFLADKFLNITPKIEEYLRKKIEHV
                     YSDEAKTGIFEEENPFFNHITDDLLETSVTLANLWKEEFSISENLKTNDLIFVQFSKE
                     GVEHFAFLRIALRETLTHLGGEVDNPIKLTQNNLPGFGTGADEALVVNLQSRKYHLIE
                     KRIKYNGTFLNYFSDNLLAVAPKISPKKSIKELEKTAQRIAESFNTDDFQFQSKVKSA
                     IFNNLEESNELSPEKLANDLFDNNLTARLSFIDQVKEAVPEPVQFDEIDASRQLKKFE
                     NQKLSLSNGIELIVPNNVYQDAESVEFIQNENGTYSILIKNIEDIQSK"
     gene            complement(5463..6719)
                     /locus_tag="VXE25_001389"
     CDS             complement(5463..6719)
                     /locus_tag="VXE25_001389"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863152.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydroxymethyltransferase"
                     /protein_id="HEV0771842.1"
                     /translation="MIFDKDDFKAYDADLWNAIAKEEERQQNNIELIASENVVSKAVM
                     AAQGSILTNKYAEGYPGRRYYGGTDVVDVVETLAIERAKEIFGAKFANVQPHSGSQAN
                     CAAYMSLIEPGDTVMGMDLASGGHLTHGAPVSFSGQTYNFVSYSVDPETELLDFDAIL
                     KQAQEVKPKLIVAGASAYSQIIDFSKFREIADAVGAKLMVDMAHIAGLVAAGLHPSPV
                     PYAHITTTTTHKTLRGPRGGLILTNDEELAKKINSAIFPGIQGGPLEHVVAAKAVSFK
                     EVLDPAFKEYAANVIKNSKAMADVFLQDPDFRIISGGTENHLFLVDVTKVVENGKVAQ
                     NLLDEVNITLNKNSIPYETLSPFKTSGIRIGAAAITARGFGEEESRKVAELIIKTLKN
                     SENEAVLEEVRSAVKELTDAFPLYEE"
     gene            complement(6781..7212)
                     /locus_tag="VXE25_001390"
     CDS             complement(6781..7212)
                     /locus_tag="VXE25_001390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000942930.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0771843.1"
                     /translation="MLRDLQETDVKAICDINQEALGYTFSPEETASQLARLSQDSHHF
                     LLGYEDAANHVLLGYVHAEVYESLYSKAGFNILALAVSPQAQGQGIGKSLLQGLEQEA
                     KRCGYGFIRLNSANHRLGAHAFYEKVGYTCDKMQKRFIRIF"
     gene            complement(7214..7816)
                     /locus_tag="VXE25_001391"
     CDS             complement(7214..7816)
                     /locus_tag="VXE25_001391"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000969297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonylcarbamoyl-AMP synthase"
                     /protein_id="HEV0771844.1"
                     /translation="MMDRIRQELENGGAVVLPTETVYGLFAKALDEKAVDHVYQLKRR
                     PRDKALNLNIASFEDILHFSKNQPTYLQKLVETFLPGPLTIILEANDRVPYWVNSDLA
                     TIGFRMPSHPITLDLIRETGPLIGPSANISGQASGVTFEQILKDFDQEVLGLEDDAFL
                     TGQDSTIVDLSGDKVKILRQGAIKREDILARLPEISFEEA"
     gene            complement(7800..8639)
                     /gene="prmC"
                     /locus_tag="VXE25_001392"
     CDS             complement(7800..8639)
                     /gene="prmC"
                     /locus_tag="VXE25_001392"
                     /EC_number="2.1.1.297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000761890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor N(5)-glutamine
                     methyltransferase"
                     /protein_id="HEV0771845.1"
                     /translation="MKLAQLFSNFEEELIRQGEEAESLSFVYRSLKNLSFTDFIFALQ
                     QEVTTEEEKQFVEDIYQQLAAHKPAQYIIGQADFYGMHLKVDERVLIPRPETEELVEL
                     ILTENLETNLSVLDIGTGSGAIALALAKNRPDWSVTAADVSQEALELASENASDQNLN
                     IFFKKSDCFAEISEKYDIIVSNPPYISREDESEVGLNVLHSEPHLALFADEDGLAIYC
                     RIAEDAKDYLKDGGKIYLEIGYKQGQSVPELFRKHLPEKKVRTLKDQFGQNRMVVVDD
                     GQD"
     gene            complement(8639..9718)
                     /gene="prfA"
                     /locus_tag="VXE25_001393"
     CDS             complement(8639..9718)
                     /gene="prfA"
                     /locus_tag="VXE25_001393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 1"
                     /protein_id="HEV0771846.1"
                     /translation="MNIYDQLQAVEDRYEELGELLSDPDVVSDTKRFMELSKEEASNR
                     DTVIAYREYKQVLQNIVDAEEMIKESGGDADLEEMAKQELKDAKAEKEEYEEKLKILL
                     LPKDPNDDKNIILEIRGAAGGDEAALFAGDLLTMYQKYAEAQGWRFEVMEASMNGVGG
                     FKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYDI
                     DPKDLRVDIYHASGAGGQNVNKVATAVRIVHLPTNIKVEMQEERTQQKNREKAMKIIR
                     ARVADHFAQIAQDEQDAERKSTIGTGDRSERIRTYNFPQNRVTDHRIGLTLQKLDTIL
                     SGKLDEVVDALVLYDQTQKLEELNK"
     gene            complement(9715..10305)
                     /locus_tag="VXE25_001394"
     CDS             complement(9715..10305)
                     /locus_tag="VXE25_001394"
                     /EC_number="2.7.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000068157.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thymidine kinase"
                     /protein_id="HEV0771847.1"
                     /translation="MAQLYYRYGTMNSGKTIEILKVAYNYEEQGKGVVIMTSALDTRD
                     GVGYVSSRIGMKRPALAIEETTDIFGYIRGLPEKPYCVLVDEAQFLKRHHVYDLARVV
                     DELDIPVMAFGLKNDFRNELFEGSKYLLLLADKIDEIKTICQYCKKKATMVLRTQDGL
                     PVYDGEQIQIGGNETYISVCRKHYFAPEINKENEEK"
     gene            10428..10610
                     /locus_tag="VXE25_001395"
     CDS             10428..10610
                     /locus_tag="VXE25_001395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005589823.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-oxalocrotonate tautomerase"
                     /protein_id="HEV0771848.1"
                     /translation="MPFVRIDLFEGRTLEQKKALAKEVTEAVVRNTGAPQSAVHVIIN
                     DMPEGTYFPQGEMRTK"
     gene            10747..12120
                     /gene="mnmE"
                     /locus_tag="VXE25_001396"
     CDS             10747..12120
                     /gene="mnmE"
                     /locus_tag="VXE25_001396"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002906470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis GTPase MnmE"
                     /protein_id="HEV0771849.1"
                     /translation="MITREFDTIAAISTPLGEGAIGIVRLSGTDSFAIAQKIFKGKDL
                     NKVASHTLNYGHIIDPLTGKVMDEVMVGAMKSPKTFTREDIIEINTHGGIAVTNEILQ
                     LAIREGARLAEPGEFTKRAFLNGRVDLTQAEAVMDIIRAKTDKAMNIAVKQLDGSLSD
                     LINNIRQEILNTLAQIEVNIDYPEYDDVEEATTAVVREKTMEFEQLLTKLLRTARRGK
                     ILREGISTAIIGRPNVGKSSLLNNLLREDKAIVTDIAGTTRDVIEEYVNINGVPLKLI
                     DTAGIRETDDIVEQIGVERSKKALKEANLVLLVLNASEPLTAQDRQLLEISQDTNRII
                     LLNKTDLPETIETSKLPEDVIRISVLKNQNIDKIEERINNLFFENAGLIEQDATYLSN
                     ARHISLIEKAVESLQAVNQGLELGMPVDLLQVDLTRTWEILGEITGDAAPDELITQLF
                     SQFCLGK"
     gene            complement(12167..13102)
                     /gene="dapA"
                     /locus_tag="VXE25_001397"
     CDS             complement(12167..13102)
                     /gene="dapA"
                     /locus_tag="VXE25_001397"
                     /EC_number="4.3.3.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002935444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate synthase"
                     /protein_id="HEV0771850.1"
                     /translation="MSYQDLKECKIITAFITPFHEDGSINFDAIPALIEHLLAHHTDG
                     ILLAGTTAESPTLTHDEELELFAAVQKVVNGRVPLIAGVGTNDTRDSIEFVKEVAEFG
                     GFAAGLAIVPYYNKPSQEGMYQHFKTIADASDLPIIIYNIPGRVVVELTPETMLRLAD
                     HPNIIGVKECTSLANMAYLIEHKPEEFLIYTGEDGDAFHAMNLGADGVISVASHTNGD
                     EMHEMFTAIAESDMKKAAAIQRKFIPKVNALFSYPSPAPVKAILNYMGFEAGPTRLPL
                     VPAPEEDAKRIIKVVVDGDYEATKATVTGVLRPDY"
     gene            complement(13158..14234)
                     /locus_tag="VXE25_001398"
     CDS             complement(13158..14234)
                     /locus_tag="VXE25_001398"
                     /EC_number="1.2.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000542485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate-semialdehyde dehydrogenase"
                     /protein_id="HEV0771851.1"
                     /translation="MGYTVAVVGATGAVGAQMIKMLEKSTLPIDKIRYLASARSAGKS
                     LKFKDQDITIEETTETAFEGVDIALFSAGGSTSAKYAPYAVKAGVVVVDNTSYFRQNP
                     DVPLVVPEVNAHALDAHNGIIACPNCSTIQMMVALEPVRQKWGLDRIIVSTYQAVSGA
                     GMGAILETQRELREVLNDGVKPRDLHAEILPSGGDKKHYPIAFNALPQIDVFTDNDYT
                     YEEMKMTKETKKIMEDDSIAVSATCVRIPVLSAHSESVYIETKEVAPIEEVKAAIAAF
                     PGAVLEDDVAHQIYPQAINAVGSRDTFVGRIRKDLDAEKGIHMWVVSDNLLKGAAWNS
                     VQIAETLHERGLVRPTAELKFELK"
     gene            complement(14577..14649)
                     /locus_tag="VXE25_001399"
     tRNA            complement(14577..14649)
                     /locus_tag="VXE25_001399"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(14614..14616),aa:Thr,seq:ggt)
     gene            complement(14749..15258)
                     /locus_tag="VXE25_001400"
     CDS             complement(14749..15258)
                     /locus_tag="VXE25_001400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="QueT transporter family protein"
                     /protein_id="HEV0771852.1"
                     /translation="MKKLTIRDVADIAIVAAIYVVLTVTPPLNAISYGAYQFRISEMM
                     NFMAFYNPKYIIGVTIGCMIANFFSFGLLDVFVGGGSTLVFLSLGVWLFAKYSKDYLF
                     NGLIRKDHFFFSILFSISMFTIAAELNIVAELPFFLTWFTTGIGEFASLIIGAIIIGK
                     IGRRIDLSK"
     regulatory      complement(15256..15352)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01054"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="PreQ1 riboswitch class II; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="preQ1"
                     /db_xref="RFAM:RF01054"
     gene            15381..15812
                     /locus_tag="VXE25_001401"
     CDS             15381..15812
                     /locus_tag="VXE25_001401"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GtrA family protein"
                     /protein_id="HEV0771853.1"
                     /translation="MKIPIQKFFNNEILAYLFFGIVTTLVAILLRLVIYQLSHQELLA
                     TALANIIGILFAFITNDTIVFKQKKKNRLIRLVKFSLARLSTFLLDLFLTFLFVTQFP
                     HIIGQFVTENIDKINAIETIIAQIFIIIINYILSKVYIFRK"
     gene            15894..16271
                     /gene="mscL"
                     /locus_tag="VXE25_001402"
     CDS             15894..16271
                     /gene="mscL"
                     /locus_tag="VXE25_001402"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001855364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="large conductance mechanosensitive channel
                     protein MscL"
                     /protein_id="HEV0771854.1"
                     /translation="MLKNLKSFLLRGNVIDLAVGVVIASAFGAIVTSLVNDIITPLIL
                     NPALKAAKVERIAQLSWHGVGYGNFLSAIINFIFVGTALFFIIKGIEKAQKLTGIKEE
                     KTAEKKPTELEVLQEIKALLEKK"
     gene            complement(16313..17407)
                     /gene="hemH"
                     /locus_tag="VXE25_001403"
     CDS             complement(16313..17407)
                     /gene="hemH"
                     /locus_tag="VXE25_001403"
                     /EC_number="4.98.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrochelatase"
                     /protein_id="HEV0771855.1"
                     /translation="MKKAILMMTFGSPEEITFEGVADFFTNIRRGVRPQDHEIQTLYD
                     NYVRIGGTPLQKITRQEVALVEARLGNEYSVYFANKFSSPFIPDVIGQMEADGIEQCI
                     CLILEPHYSFYSVMGYEKFLESKQIQFLVIKDWYQEEALLNYWADEIAKILKEEVKQD
                     SFKVIFSAHSVPIFALDFGDPYIDQIFENSKLVAEKLGLSSKQYTNTWQSESDIGIPW
                     IKPDVLEYLREQTEHPDHYIFVPISFISEHIEVLFDNDVECYDLCQEFGVNYHRPPMP
                     NTDSRLIDALVNTVRVNENQEFKEFLPEEETFDELVPSDETKNILAESEDLQMPEFVK
                     KLIEKKGRENVKMPYLIKKMLEKAGKLPKE"
     gene            17562..18785
                     /gene="pepT"
                     /locus_tag="VXE25_001404"
     CDS             17562..18785
                     /gene="pepT"
                     /locus_tag="VXE25_001404"
                     /EC_number="3.4.11.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000222045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase T"
                     /protein_id="HEV0771856.1"
                     /translation="MTYPNLLDRFLTYVKVNTRSDEHSTTTPSTQSQVDFATNVLIPE
                     MKRVGLQNVYYLPNGFAIGTLPANDPSLTRKIGFISHMDTADFNAEGVNPQVIENYDG
                     GVIELGNSGFKLDPADFKSLEKYPGQTLITTDGTTLLGADDKSGIAEIMTAIEYLTAH
                     PEIKHCEIRVGFGPDEEIGVGANKFDAEDFDVDFAYTVDGGPLGELQYETFSAAGAEL
                     HFQGRNVHPGTAKGQMVNALQLAIDFHNQLPENDRPELTEGYQGFYHLMDVTGSVEEA
                     RASYIIRDFEKDAFEARKASMQSIADKMNEELGSDRVTLNLTDQYYNMKEVIEKDMTP
                     ITIAKAVMEDLGITPIIESIRGGTDGSKISFMGIPTPNIFAGGENMHGRFEYVSLQTM
                     ERAVDTIIGIVAYKG"
     gene            complement(18821..19450)
                     /locus_tag="VXE25_001405"
     CDS             complement(18821..19450)
                     /locus_tag="VXE25_001405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000030436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771857.1"
                     /translation="MSKANQLLEQIHEEGIRQSLAEEVENLKAATNKADADLDEVNSQ
                     VKDVLTRIASALQQEKENAEQDPQTLVLYQKLYDILMSLHSYLESNNGSDADFDKVDA
                     LLDQLSAKSKDKTALLEPTKAILVLNHQIQSKASASEETSPARNAEANGDNTSAENQP
                     NATAESNIETASDENKPSNTRDSKPAESTSENETTESSTTTGNQEKPVE"
     gene            19415..19636
                     /locus_tag="VXE25_001406"
     CDS             19415..19636
                     /locus_tag="VXE25_001406"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844654.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771858.1"
                     /translation="MDLFQELICLAQKTFYFFLAICRRLLVAIYHVLLKQESYNPRLQ
                     GLTEIRNPDKTMFVQDAIRFAQQHGFNML"
     gene            complement(19773..19982)
                     /locus_tag="VXE25_001407"
                     /pseudo
     CDS             complement(19773..19982)
                     /locus_tag="VXE25_001407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809565.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="histidine triad protein"
     gene            complement(20069..20332)
                     /locus_tag="VXE25_001408"
     CDS             complement(20069..20332)
                     /locus_tag="VXE25_001408"
                     /inference="COORDINATES: protein motif:HMM:NF016182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal-type histidine triad protein"
                     /protein_id="HEV0771859.1"
                     /translation="MLEITLKSPYQFAHILFQPTIVPHGGHYHFIPESDLSAGELAAT
                     YVFNPNDIVRDTGDAYIVRHGVTITIFLSHLLTIPHHTLTRKR"
     gene            complement(20376..20936)
                     /locus_tag="VXE25_001409"
                     /pseudo
     CDS             complement(20376..20936)
                     /locus_tag="VXE25_001409"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000672589.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal-type histidine triad protein"
     gene            complement(21162..23750)
                     /locus_tag="VXE25_001410"
     CDS             complement(21162..23750)
                     /locus_tag="VXE25_001410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000672589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal-type histidine triad protein"
                     /protein_id="HEV0771860.1"
                     /translation="MKFSKKYIAAGSAVIVSLSLCAYALNQHRSQENKDNNRVSYVDG
                     SQSSQKSENLTPDQVSQKEGIQAEQIVIKITDQGYVTSHGDHYHYYNGKVPYDALFSE
                     ELLMKDPNYQLKDADIVNEVKGGYIIKVDGKYYVYLKDAAHADNVRTKDEINRQKQEH
                     VKDNEKVNSNVAVARSQGRYTTNDGYVFNPADIIEDTGNAYIVPHGGHYHYIPKSDLS
                     ASELAAAKAHLAGKNMQPSQLSYSSTPSPSLPINPGTSHEKHEEDGYGFDANRIIAED
                     ESGFVMSHGDHNHYFFKKDLTEEQIKAAQKHLEEVKTSHNGLDSLSSHEQDYPSNAKE
                     MKDLDKKIEEKIAGIMKQYGVKRESIVVNKEKNAIIYPHGDHHHADPIDEHKPVGIGH
                     SHSNYELFKPEEGVAKKEGNKVYTGEELTNVVNLLKNSTFNNQNFTLANGQKRVSFSF
                     PPELEKKLGINMLVKLITPDGKVLEKVSGKVFGEGVGNIANFELDQPYLPGQTFKYTI
                     ASKDYPEVSYDGTFTVPTSLAYKMASQTIFYPFHAGDTYLRVNPQFAVPKGTDALVRV
                     FDEFHGNAYLENNYKVGEIKLPIPKLNQGTTRTAGNKIPVTFMANAYLDNQSTYIVEV
                     PILEKENQTDKPSILPQFKRNKAQENSKLDEKVEEPKTSEKVEKEKLSETGNSTSNST
                     LEEVPTVDPVQEKVAKFAESYGMKLENVLFNMDGTIELYLPSGEVIKKNMADFTGEAP
                     QGNGENKPSENGKVSTGTVENQPTENKPADSLPEAPNEKPVKPENSTDNGMLNPEGNV
                     GSDPMLDSALEEAPAVDPVQEKLEKFTASYGLGLDSVIFNMDGTIELRLPSGEVIKKN
                     LSDLIA"
BASE COUNT         6860 a         4939 c         4357 g         7779 t
ORIGIN      
        1 taccaaccat ctggcttatc tgaatatccc ttgaagccta attgattaaa agtagttatt
       61 tgaccagtac cttgattgat gttttcttca acttcattaa agcctatact tctcttgcat
      121 aatccctaac ttgatcttct gtccttaaag tcattttcta ttcctcgtca ctaaaattat
      181 cttcaaaact aataatatca ttaggagtgc aagataaagc cttacatatt ctttctaaat
      241 tcttaaatgt aattggttta tcctttccca tttgtgccat aacatttgtt gtaagtcctg
      301 ccatagctat tacatctgtt ttctttagtc ctttttttgc taactgtatc cataatggtt
      361 tatagttaag tgccataata tccctctttt tttcttcatt agatttattt aattatagca
      421 taaatattga tttcattcaa tcttacattg atttagtgat ttgttttaga gaatttgttg
      481 tgttattccg tccttatttt gccataaatt gttttaagtg ggacctctta tccttaccat
      541 ttttacctcc taattttgag tataaaaaag acgatagagt ttttaatttc tatcgtctga
      601 gatttacata ttaaattttc atcacaaaat aagactcttt aaagaatctt taaattcatt
      661 ggtatgctgc ttacaatatc cattattaaa atggatacta taaacagcac accaactatt
      721 tattttttga gttttaaact ttggtagaag tcttgaactc cttatattta cataactatt
      781 tgcctctata actattatga cacgaaacca acaagcaagt tcaagcacct ccatatcttt
      841 attcaaatga ggactaagat attcacaaac tttatcataa acctctttat cttttttcat
      901 aaaaggggca tacaacttag caaatttatc ctaaaatttt ttgttgcctt tatcaatcat
      961 ttcaacactc ctttaaatat aaaaatgatc ctatcaatct ttatattgag cctattttct
     1021 aattgatacc ttgcaagaaa ggaataatag ccgttcctat accaagtagg aatgtaataa
     1081 atgcagaaag tcatatactg tcattctttt ctattaaatc attttgaagt gtctcaaagc
     1141 atccatgatg gcttcttctt tttcaggtgt acactgtgga ataatttgtt tatccttttt
     1201 agacttgttg taatgttctc gtaattctat tccacatttc ttttttatct gtgcaatata
     1261 taatgtcgaa acttttaatt caaatttatt ccaaacatat tctttgattt gagcatatgt
     1321 tgctttgctc tccgcacttg tcaaattcat ctcatccagc tcaatttcaa cacttatgtg
     1381 cttatcgaca tcgagtttgg acaaaagtgc taccgtctcg acgtgatgcg tttgaggaaa
     1441 tagatccacc ggctggactt tcttcaattc atatcccaat tcttggtaga gtttgatatc
     1501 acgcgccatg gttgcgacat tgcaggagat ataggcgatg cgatcggctc ctgtttgggc
     1561 gcttgctttg ataaagcttt ctgtcaagcc cttgcgtgga ggatcaacca agataacggt
     1621 tggttgaatc ccatctttaa gccaattctt catagcattt tcagctgtgt cacagacata
     1681 gtgggcgttt gaaatattgt tcaactgagc atttttttta ctattctcaa ccgcttctgg
     1741 aatcagttca acaccgtaga cttctttgac atgcttggcg actgataaac caatggttcc
     1801 aataccagaa taagcatcaa taaccacgtc atcttttttt aactctgcaa agtcaatggc
     1861 tgtttgatag agtttctccg ccatttcagt attgacttgg taaaaggctg ggccagcgat
     1921 ttggaagtca tttcccaaca tctggtccgt aatatagtct tgaccataaa gagtgcgcca
     1981 ctccttacca aaaatcgcat tggtattctg gtcgttgata ttttgcatga cagacacaat
     2041 ctctgggaac tgcttgataa cttgttcaat caattggtca acacgaaaaa cttttggacg
     2101 agttgtcacc aaaacgacca tgatttgtcc tgaatagtga ccacgacgca ccacaagatt
     2161 ccgaatcaat ccagactgtt ccttttcgtc ataaggtttt aaatcaaaac gacggagcag
     2221 gtctcgaaga gctactacga cttggtcaat gacaggatcc tggataaaga aatcttcaag
     2281 gggcatgagg ttgtgcgaat tcttacggaa aaatcctgtt tccaagacac cattcactcg
     2341 acgaacgggc acctgcgcct tattgcgata cttgactgga tgttccatac caagcgtttc
     2401 agcaacttct acatctgcaa ttccagcaat cttgtagaga ctgtccttga cttgcttggt
     2461 tttaaacttg agctgttctg gataagaaag gtgtcctaaa tccgcgattc ctgaacgcag
     2521 gtaagccaaa tctagatctt gattacggtg tggtgactgg acaaggtatt tttcaacttt
     2581 tccaaagcca atctttttat tgaccttgag gacacgcatg agaatttttt cactcggtaa
     2641 agcattctct acaaaaaaga ccaaaccatc taccttggca actcctgccc cttcatgggt
     2701 caaatcaaca atttcaactt ctacaatatc atttttcttt aacattcttt tctctttcta
     2761 ttggccgaca aaaaagacgg caacgttacg gttaccatcc attataccat gaaatttctt
     2821 aagaaccaaa actcttgaag aagttgacaa gggcttgcca gagggagctt aagaagttac
     2881 caccgtcctc tagcgcctta tccgcatcaa agttaaggtt gatattttta aaactgtcgc
     2941 cagcttgtga tacgatgctt tgtttaaggt catttagggt tttagtgaaa tctgcattgc
     3001 tgaggatatc actctttgag agattcaagg caaaattgat gatgatattg atctggtttc
     3061 ctgttatgac ctgatcaagt ttgtaatttt ttaaggtatc ttcaacaatc ttgcggatat
     3121 cttcttctgt cagatttccc ttgctttctt tagctttggc gagtcctgac ttgatatcag
     3181 ctagggcaac gtttaattta ttagcatcat agcctgattt gtccttgttt tcagcattga
     3241 tatctgacaa agcctttagc tcttcttgag ccaaatcttt attggcttgc ggcaccttgg
     3301 ctccattagc ttctagcgaa tagtagatcc cagccaaagc actctcacct gtaactggaa
     3361 tgggtgctgc tacagtgatt ttggcgtgtt ccacacccaa agttacggct gcatttcggt
     3421 acatatcctg agttacctta gtgatgtttt caggtgtttc aatcttgacc tcaagtggcg
     3481 atttgtcacc tagcttttga atcttggctg atgaatacaa ctgtaagcta gagtcattgg
     3541 ccacattcat gattttagaa taaacatcag gtgtcatggt cttgagttct ttggtatctg
     3601 ttgaggcatt gtagcccagt tttttaagag tttgattttt ttggtcttca gatagggaag
     3661 aacctaggac atattcaggt tggacatagg tttcatcgat aactttttga acatctgttg
     3721 ctgcatggac gctattcata gctgttactg cccacaagat cgcagcgcta gtcagaaaga
     3781 gtttctttct catagggaat ttcctccttt acttctttag agtaatatat ctatcttaaa
     3841 gaaaacttat aacaaaaaca cctggtctag ccagatgttg aaaagagagt gaaacatttg
     3901 ataatgtaaa ggttaagtcg tacctgtcta gaataataat agtttcctcc atttacatag
     3961 agttcagcac cgtgaaaaat ggaaatgggg tgaatataac tataagtctt tccagtcgta
     4021 ttaccaagca agggggcaac agtctcacga gagtactgtt tggctagagc caaggtattt
     4081 tccttgccat tttgggcgat aaaatcgata taggcaggtc caaaattata ggcttgaaca
     4141 gctgtccaga tatctacacc cttcttctgc gccagataga gattgcctgt cagagtttga
     4201 atgccttgcc gaatgctaga ggcattatca ttgatggtgt tggtggaacc acttgcagac
     4261 tcactagact gcataacatc gccttctttt ccttttgttt cagtataaat catagcaagc
     4321 acaagctctt cgtttgctgg ggtgtcttgt tcactcaata tttctcgcac catgggttga
     4381 taggtcatga cttgtttgac atcttgatga acgcggtaag ctttatagcc agcaaaaagg
     4441 aagactgcta gtacaagcac tcttcgaatt cgtttaaaca ttatttactt tggatatcct
     4501 cgatattttt gattaagata gagtaggttc cattttcgtt ttggataaac tcaacagact
     4561 cggcgtcttg atagacgtta ttgggaacga tgagctcaat tccatttgat aaggagagtt
     4621 tttggttttc aaatttcttt aattggcgac tggcatcaat ttcatcaaat tgaacaggtt
     4681 ctggtacggc ttctttgact tggtcaataa agctcaaacg agccgtcaga ttgttgtcaa
     4741 aaaggtcatt agccaatttc tcaggtgaca attcattgct ttcttctagg ttgttgaaaa
     4801 tagctgattt gaccttggat tgaaattgaa aatcatctgt gttaaaagat tcagcaattc
     4861 tctgggctgt tttttccagt tccttgatag attttttagg agaaatctta ggagcgacag
     4921 caagaagatt atctgaaaaa tagttcaaaa aagtcccgtt gtacttgatt cgtttttcaa
     4981 tcaggtgata cttgcgactc tgaagattga ccaccaaggc ctcgtcagca cccgttccaa
     5041 atccaggcag gttattctga gtcagcttga ttggattatc aacttctcct ccgaggtggg
     5101 tcaaggtctc ccgcagggca attcgcaaga aagcgaaatg ttctacacct tctttagaaa
     5161 attgaacaaa aatcaagtca ttggtcttga gattttcaga aatgctaaac tcctctttcc
     5221 agagattagc cagcgttact gatgtctcca acaaatcgtc tgtaatatga ttgaagaagg
     5281 gattttcttc ttcgaaaatc ccagtcttgg cttcatctga atacacatgt tcaatttttt
     5341 tacgtaggta ttcttcgatt tttggagtaa tattgagaaa cttatctgct aagaacagct
     5401 cggtatcatc cggactgaac tggtgaataa tggctttctt aatataaatg tccataaaag
     5461 ttttattcct cgtataatgg gaaggcatct gtcaattctt tgactgcact tctcacttct
     5521 tctaatacag cctcattttc tgaattctta agggttttaa tgatgagttc agccactttg
     5581 cgactttctt cttcaccaaa tccacgtgca gtaatagctg ctgctccgat acgaatccca
     5641 cttgtcttga atggtgacaa ggtttcgtaa gggattgaat ttttatttag ggtaatattg
     5701 acttcatcca gcaagttttg agcaactttt ccgttttcta caaccttagt cacatcaaca
     5761 aggaagagat ggttttcagt tccacctgaa ataatacgga aatcagggtc ttgcaagaag
     5821 acatctgcca tagccttgct gttcttaatt acattggcag catattcctt gaaggctgga
     5881 tccaaaactt ctttgaagga aactgcctta gccgccacaa catgctctaa aggaccgccc
     5941 tgaatacctg ggaaaatagc tgaattgatt tttttagcaa gttcttcgtc attggtcaaa
     6001 atcaaaccac cacgaggtcc acgaagggtt ttgtgggtcg ttgttgtagt gatatgagcg
     6061 tatggcactg ggcttgggtg aagaccagct gcaaccaagc cagcgatgtg ggccatatca
     6121 accataagct tcgcaccgac agcatctgcg atttcacgga attttgaaaa gtcaataatt
     6181 tgagaatagg ctgaagcacc agctacaatc agttttggtt ttacttcttg ggcttgtttc
     6241 aagatagcat caaagtctaa gagttccgtt tcaggatcaa cactataaga aacaaagttg
     6301 taggtttgac cagagaagct aacaggagcc ccatgagtca aatgaccacc tgatgccaaa
     6361 tccattccca taaccgtatc acctggctca atcaaggaca tgtaagccgc acagttagct
     6421 tggcttcctg aatgtggttg gacattggca aatttagcac cgaaaatttc ttttgcgcgt
     6481 tcaatagcaa gagtctctac aacgtctact acatcagttc caccataata acggcgtcct
     6541 gggtaaccct cggcatattt atttgtcaag atagaccctt gagctgccat aacagccttg
     6601 gaaactacgt tttccgaagc aattaactcg atattatttt gttggcgttc ttcttctttg
     6661 gcaatagcat tccagagatc agcatcatat gctttaaaat catctttgtc aaaaatcata
     6721 ggtcttctcc tttattgtgt gactagtcca ttagtttgat tttacaataa gaaaatcaaa
     6781 ctaaaagatg cgaataaacc gtttctgcat tttatcacaa gtatagccaa ctttttcata
     6841 aaatgcatga gcacccagac gatgattggc agaatttaag cggataaacc cataaccaca
     6901 tcttttggct tcttgttcca acccttgtag taaactttta ccgatacctt gaccttgcgc
     6961 ttgaggtgaa actgctaaag ctaagatatt aaatcctgct ttggaataga gtgattcgta
     7021 aacttcagcg tggacatatc caagtaagac atgattagct gcatcctcat agccaagtag
     7081 gaaatgatgg gaatcctgag acagtctagc tagttggcta gccgtttcct ctggactaaa
     7141 agtataaccc aaagcctctt ggttgatgtc acatatcgct ttcacatctg tttcttgcaa
     7201 atctcttagc atttcaagcc tcctcaaaag aaatctctgg caaccgagca agaatatctt
     7261 ctcgtttaat tgcgccttgg cgtaagattt tcaccttgtc tccagacaaa tccacaatag
     7321 ttgaatcctg tccagttaga aaagcatcgt cttccagacc cagaacctct tggtcaaaat
     7381 ccttcagaat ttgttcaaag gttacaccac ttgcctgacc tgagatattg gcagacggcc
     7441 caatcaaggg acctgtctct cgaattaaat ccagtgtgat agggtgactg ggcatccgaa
     7501 atccaatagt tgcaaggtca gaatttaccc aatagggaac tcggtcattg gcttcgagaa
     7561 taatggtcaa gggacctggc aaaaaggtct ctacaagttt ttgtagataa gttggctgat
     7621 tcttagaaaa gtgcaagata tcctcgaaag aggcgatatt gagattgagt gccttatctc
     7681 taggacgacg tttgagttgg taaacatggt caactgcttt ttcatctaag gccttggcaa
     7741 aaagaccata aacagtctct gtaggtagaa cgacagctcc accattttcc aactcttgtc
     7801 taatcctgtc catcatcaac cacaaccatc ctattttgac caaattggtc tttgagtgtt
     7861 cgaacttttt tttcaggaag atgttttcta aaaagttcgg gaacactttg accttgcttg
     7921 tatccaattt caaggtaaat cttaccacca tccttgagat agtcttttgc atcttccgca
     7981 attctacagt aaatagctag gccatcctcg tctgcaaaga gagctagatg aggctccgaa
     8041 tgcaaaacat tcaagcctac ctctgactca tcttcacgag agatataggg tggattggat
     8101 acaattatat catatttttc agaaatttct gcaaaacaat cagatttttt aaaaaatata
     8161 ttaagatttt gatcgctagc attctctgat gcaagctcta aggcctcttg agaaacatct
     8221 gctgctgtca ctgaccaatc tggtctattt tttgctagag cgagagcaat agctccacta
     8281 cctgttccaa tatccagaac tgagagattc gtctcaagat tttcagttag aataagctcc
     8341 actaactcct ctgtttctgg acgaggaatc aaaacccgtt catccacctt taaatgcatt
     8401 ccataaaaat ctgcctgtcc aatgatgtac tgagctggct tgtgagctgc tagttgctgg
     8461 taaatatctt ctacaaattg tttttcttcc tctgttgtca cctcctgctg gagggcaaaa
     8521 ataaagtctg taaaagatag atttttcaga ctacgataga caaaagagag gctttccgct
     8581 tcctctcctt gtcttatcaa ctcttcttca aaatttgaaa ataattgagc taatttcatt
     8641 atttgtttaa ttcttctagt ttttgtgttt ggtcataaag caccaaggca tccacaactt
     8701 cgtccaattt accagacaaa atcgtatcta gtttttggag ggtcaagccg atacggtggt
     8761 ctgtgacacg gttttgaggg aagttataag ttcggatccg ttctgaacgg tcaccagtac
     8821 cgattgtcga cttacgctca gcgtcttgtt catcctgagc aatctgagca aagtggtcag
     8881 cgacgcgtgc acggataatc ttcatagcct tctcacggtt cttctgctgg gtacgttctt
     8941 cctgcatctc aaccttgata ttggttggca agtgaacgat acgaacggca gtcgcaacct
     9001 tattgacgtt ctgtccacca gcacctgatg cgtggtaaat atcaacacga agatcttttg
     9061 gatcgatatc gtattctact tcttcgactt caggcatgac aagaactgtg gcagttgagg
     9121 tatgaacacg accttggctt tctgtcacgg ggacacgctg cacacggtgg gcacctgatt
     9181 cgtacttaag cttagagtat acagactgac ctgaaaccat agcaaccact tctttaaacc
     9241 caccgacacc attcatagag gcttccatga cttcaaagcg ccagccttgg gcttccgcat
     9301 acttttggta catagttagc aaatctccag cgaaaagtgc cgcttcgtct ccaccagctg
     9361 ctccacggat ttcaaggatg atattcttgt catcgtttgg atcctttgga aggagcaaaa
     9421 ttttcagttt ttcttcatat tcttcttttt cagccttggc atctttgagt tcttgcttgg
     9481 ccatttcttc caagtccgca tctccgcctg attccttaat catctcttcg gcatcgacga
     9541 tattttgaag gacttgttta tactcacggt aggctattac ggtatcacga ttggaagctt
     9601 cttcttttga aagctccata aaacgcttgg tgtctgaaac gacatcaggg tcactcagca
     9661 attctcctag ttcttcataa cggtcttcta cagcttgtag ttgatcatag atgttcattt
     9721 ttcttcattc tccttattga tttcaggggc aaaataatgt ttacggcaaa ccgagatata
     9781 ggtttcatta ccaccaattt ggatctgttc tccatcgtaa acgggcagtc catcctgtgt
     9841 tcgcaacacc atggtcgcct ttttcttgca atactgacag atggtcttga tttcgtcaat
     9901 cttgtctgct aaaagcaaga gatatttgga accttcgaac aattcattgc gaaagtcatt
     9961 tttcaagcca aaagccatga cgggtatgtc taactcgtcc acaacacgag ctaggtcata
    10021 aacatggtgg cgtttgagaa actgggcttc atcgaccaac acacagtaag gtttttctgg
    10081 taggcctcgg atatagccaa agatatccgt tgtttcctca atcgcaaggg cagggcgttt
    10141 catgccaatt cgactcgaca catagccaac accgtcacgc gtatccagag ctgaagtcat
    10201 aatcacaaca ccttttcctt gctcctcata gttataggcc accttgagaa tctcgattgt
    10261 ctttccagag ttcatggtcc cataacgata atacaactgt gccatgtttc ttgcttcacg
    10321 tccatttcta aatttttgct acattctagt atatcataat tttcttaagc tttaaacggc
    10381 aaaatgtggt aaaatggaag aaatcaaaac tagtggagga agctattatg ccatttgtac
    10441 gcatcgattt atttgaagga cgcacgctcg agcaaaagaa agctcttgct aaggaagtaa
    10501 cggaagcagt tgtccgcaac actggagccc ctcaatctgc tgtccatgtc atcatcaacg
    10561 acatgccaga aggaacttac ttcccacaag gggaaatgcg tactaaataa gctagcttaa
    10621 gcagaattgc ttaggctttt tcaatctcca agtagcattc attgaagaaa tatcctaaat
    10681 ttgttacaat ttgaaaagaa acttggagaa tttccaagaa aatagctatt aattaaagga
    10741 aacattatga ttacacgtga atttgatacc atcgctgcta tctctactcc actaggtgaa
    10801 ggggctattg gtattgtccg cctgagcgga acagacagtt ttgctattgc gcaaaagatt
    10861 tttaaaggaa aagacttgaa caaggttgcc agccacactc tcaactacgg tcacattatt
    10921 gatcctctga ctggtaaagt catggacgag gttatggttg gggctatgaa gtctccaaag
    10981 accttcactc gtgaggatat tatcgagatt aacacccacg gtggtattgc ggtgaccaat
    11041 gagattctcc agctagctat ccgtgaagga gctcggttgg cagaacctgg tgaatttacc
    11101 aaacgtgcct ttttaaacgg tcgcgtagat ttgacacagg ccgaggcggt gatggatatc
    11161 atccgcgcca agacagacaa ggccatgaac atcgcggtca aacaacttga tggttccctt
    11221 tctgatctta tcaataatat ccgtcaagaa atccttaaca cacttgccca aattgaggtc
    11281 aatatcgact atcctgagta tgacgatgtt gaggaagcca ctactgctgt tgtccgagag
    11341 aagacaatgg agtttgagca attactaacc aagctcctta ggacagcacg tcgtggtaaa
    11401 atccttcgtg aaggaatttc aacggctatc attggacgtc ccaacgttgg gaaatcaagc
    11461 cttctcaaca acctcttgcg tgaggacaag gctatcgtaa ccgatatcgc tgggacaaca
    11521 cgagatgtca tcgaagagta cgtcaacatc aatggtgtac ctctcaaatt gattgataca
    11581 gctggtattc gtgaaacgga tgatatagtg gaacaaatcg gtgttgagcg ttcgaaaaaa
    11641 gccctcaagg aagccaactt ggttctacta gtgctaaatg ccagtgaacc actgactgcg
    11701 caagacagac aacttcttga aattagccaa gataccaatc gcattattct acttaataaa
    11761 accgacctgc cagaaacgat tgaaacttcg aaactacctg aagacgttat ccgtatttca
    11821 gtccttaaaa accaaaacat cgacaagatt gaagagcgaa tcaacaacct cttctttgaa
    11881 aatgctggct tgattgagca agatgctact tacttgtcaa acgcccgtca catttccctg
    11941 attgaaaaag cagttgaaag cctacaagcc gttaatcaag gtcttgagct ggggatgcca
    12001 gttgatttgc ttcaagttga cttgactcgt acttgggaaa tcctcggaga aatcactggg
    12061 gatgctgctc cagatgaact catcacccaa ctctttagcc aattctgttt aggaaaataa
    12121 gaaaaatcca tgatccttca ttcggtcatg gattttattg tctttattag taatctggtc
    12181 ttaagacccc tgttacagtt gccttagttg cttcgtagtc gccatctacg acaaccttga
    12241 taatgcgttt ggcatcttct tctggtgctg gaacaagagg tagacgagtg ggtccagctt
    12301 caaatcccat atagttaaga attgccttaa ctggagcagg acttggataa gagaagagag
    12361 cattaacctt aggaatgaat ttacgctgaa ttgctgcggc tttcttcata tcgctttctg
    12421 caatggcagt aaacatctcg tgcatttcat ccccatttgt atgagaggca acagaaataa
    12481 ccccatccgc cccaaggttc atggcatgga aagcatctcc atcctcacct gtataaatca
    12541 agaactcttc aggcttgtgc tcaatcaagt aagccatatt agccaagcta gtacattctt
    12601 tgacaccgat aatatttgga tggtcagcca agcgaagcat ggtttctgga gtcaattcga
    12661 caactacacg ccctggaatg ttatagataa taattggtag gtcagaagca tctgcaatag
    12721 tcttaaagtg ctgatacatc ccttcttgag aaggtttgtt gtagtaagga acaatagcaa
    12781 gcccagctgc gaaaccacca aattccgcta cttctttgac aaactcaata gagtcacgcg
    12841 tatcattagt acctacaccc gcaatcaaag gaacgcgtcc attgacaacc ttttgtacag
    12901 ccgcaaacaa ctccaactcc tcatcgtggg tcaaagttgg actctcagca gtcgttcctg
    12961 cgagaagaat tccatccgta tgatgggcca ataaatgctc aatcaaggct ggaatagcat
    13021 caaagttaat agaaccatcc tcatgaaagg gggtaataaa ggctgtaatg attttacatt
    13081 cttttaaatc ttgataagac atgaaaacac ctctctattt caaagaagga gttcatctga
    13141 actcctaaac gatatgacta ttttaattca aatttcaatt cggctgttgg acgaaccaat
    13201 ccacgttcat gaagagtttc agcaatctga actgagttcc aagcagcacc tttgagaagg
    13261 ttatctgaaa caacccacat gtgaattcct ttttctgcat ccaagtcttt acggatacga
    13321 ccaacaaagg tatcacgcga accaactgca ttgatagctt gaggatagat ttgatgagct
    13381 acatcatctt caagaacagc acctgggaag gctgcgatag ctgcttttac ttcttcgatt
    13441 ggagccactt cttttgtttc gatataaaca gactcagagt gagctgacaa gactggaata
    13501 cgcacacatg ttgcagatac tgcaatgcta tcatcttcca taattttctt agtttccttg
    13561 gtcatcttca tctcttcgta agtgtaatca ttgtcagtga agacatcgat ttgtggaaga
    13621 gcattgaagg cgataggata atgtttcttg tcaccgcctg aaggtaagat ttccgcatgc
    13681 aaatcacgtg gtttcactcc atcattcaag acctcacgaa gttcacgttg tgtctcaaga
    13741 attgctccca taccagcacc tgaaacggct tgataagttg aaacaatgat acggtccaag
    13801 ccccattttt ggcgaaccgg ctcaagagcc accatcattt ggattgttga acagttaggg
    13861 caggcaatga ttccgttgtg ggcatcaagt gcatgagcat tgacctctgg aacaaccaaa
    13921 ggaacatctg gattttgacg gaaataagat gtattatcca ctactaccac gccagctttt
    13981 actgcgtatg gtgcatactt agctgatgtc gaaccacctg ctgaaaagag agcaatatca
    14041 actccttcaa aagctgtttc agtcgtttct tcaatcgtaa tatcttgatc tttaaatttc
    14101 aatgacttac ctgctgaacg tgcagaagca aggtaacgga ttttatcgat tggaagtgtt
    14161 gatttttcca acatttttat catctgagca ccgacagcac ctgtcgcgcc gactacagca
    14221 actgtatatc ccataaataa cctctttcgg aattttctaa aaatttctat aatagaagta
    14281 ttatactact ttttccatga attgcaaagc tttttcatca ttttttggaa aataaaaatc
    14341 cccaatcgct agactaggga ttaagaggca tcttcatgtg atgagcaggt tcacacaact
    14401 catcaaggtc cgctcctgcg ttatgacctc cttatgctca atagtagccc gaagactacc
    14461 tatcgactca tcgcatattc tatattacta gagatagttg attttgtcaa taagaaattt
    14521 tttcgatcga gtataacaaa aaactctcgt attcaagagt ttccctatac atatcatgct
    14581 aattgccggg attgaaccgg cgacctcatc cttaccatgg atgcgctctg ccaactgagc
    14641 taaatcagct tacttaagaa gtatactata ttcagaaaaa cttgtcaagt ttccttagaa
    14701 attttccata ggaaaaagcc aggtaagaac tacctagctt atcttcttct atttacttaa
    14761 atcaattcga cgaccaattt taccaataat aatcgcccca ataatcaatg aagcaaattc
    14821 accgattcct gttgtaaacc aagtaaggaa gaatggtaat tctgctacaa tatttaactc
    14881 tgcagcgata gtaaacatgg aaattgaaaa gaggattgaa aagaagaaat gatcttttcg
    14941 aatcaatccg ttaaagaggt aatccttgct atattttgca aaaagccaaa cacctaaact
    15001 gaggaatact aaggttgaac caccaccaac aaagacatct agcagtccga agctaaagaa
    15061 attagcaatc atacaaccga tggtaactcc gatgatgtac ttaggattgt aaaaagccat
    15121 aaagttcatc atttctgaaa tacgaaactg ataagcacca tagctgatgg catttagggg
    15181 cggtgtgaca gtcaaaacga cgtagatagc agcgacgatt gcaatatctg caacatcacg
    15241 aatagttaat tttttcatct tttctccttt ggcggttgcc cgcgtgtaat atgcttggtg
    15301 aaagaagcta agcaccaagg gttgctttat tcaaccctac tagtatagca caatagcctg
    15361 ctttatgcta tacttaacac atgaaaattc ctattcaaaa attttttaac aatgaaatct
    15421 tagcctatct cttttttggt atagtgacta ctcttgttgc tatactatta cgattagtca
    15481 tttatcagct aagtcatcaa gaactccttg ctacggcctt ggcaaatatt atcggtattt
    15541 tatttgcctt tatcacaaat gatacaattg tatttaagca aaaaaagaaa aatagactta
    15601 tccgtttagt gaaattttct cttgctcgcc tttctacttt tctgttagac ttgtttttaa
    15661 cttttctctt tgtaacccaa tttcctcaca tcatagggca attcgtaact gaaaacattg
    15721 ataagataaa tgctattgaa acaataattg cacaaatatt cattattatc atcaattata
    15781 tcttgagcaa ggtctatatt tttagaaaat aatgctccat ttatgagcct tttaattgcc
    15841 ttctataatg atttaggata caatgaaaca cgaaacattg aaaggaaaac agtatgttaa
    15901 aaaatctaaa atcgttcttg cttcgaggaa atgttattga ccttgctgtc ggtgttgtaa
    15961 ttgcctctgc ttttggtgct atcgttactt cacttgtaaa cgacattatc actcctctta
    16021 ttttaaatcc cgctttgaaa gctgctaaag ttgaacgtat cgctcaactt tcttggcatg
    16081 gagtcggcta tggtaacttc ttaagtgcta ttatcaattt tatctttgtg ggtaccgccc
    16141 tcttctttat tatcaagggc attgaaaaag cacagaaact gactggcata aaggaagaaa
    16201 aaactgccga aaaaaaacca accgaattgg aagtccttca agaaataaaa gctctccttg
    16261 agaaaaaata atcgattaaa aggatctagc gcaaagctaa atcctttttt ctttactctt
    16321 tgggtaactt gcctgctttt tcaagcattt ttttgataag ataaggcatc ttaacattct
    16381 cccgcccttt tttctcaatc agttttttca caaattctgg catttgtaaa tcttcagatt
    16441 cagccaaaat gttttttgtc tcgtctgaag gaactaactc atcaaaggtc tcttcttctg
    16501 ggagaaattc cttaaactct tgattttcat tgactctaac tgtattgacc aaagcatcaa
    16561 tcaaacgaga atctgtattt ggcattggtg gacgatggta gtttacccca aattcctgac
    16621 ataaatcata acattccaca tcattgtcaa acaagacctc aatatgctca ctgatgaaac
    16681 taataggtac aaaaatataa tggtctggat gttctgtctg ttctctgaga tactccaaaa
    16741 catctggttt aatccatgga ataccaatat cactctcact ctgccaagtg ttagtatatt
    16801 gttttgaact caagcccagt ttttcagcga ctagcttgct attttcgaaa atttggtcta
    16861 tataaggatc accaaagtcc aaggcaaaaa taggcacact atgggctgaa aagatgactt
    16921 taaagctgtc ttgctttact tcttctttta aaatcttagc aatttcatct gcccaatagt
    16981 ttaagagcgc ttcttcctga taccagtcct taatgaccaa aaattgaatt tgtttgcttt
    17041 ctaaaaattt ttcatagccc atgacagagt agaaagaata atggggctcc aaaatcaagc
    17101 aaatacactg ttcaattccg tctgcttcca tttgaccgat cacatctgga ataaagggac
    17161 tggaaaactt attagcaaag tagacactgt attcattccc cagcctagct tctaccaagg
    17221 caacctcttg acgggtaatt ttttgcagag gcgtgcctcc aattcgtaca taattatcat
    17281 agagagtctg aatctcgtgg tcttggggtc tcaccccacg acgaatattt gtgaaaaaat
    17341 cagctacacc ttcaaaggta atctcttctg gtgaaccgaa ggtcatcatt aaaattgctt
    17401 ttttcatgac tgcttccttg tgatgttttt atcaagttta ttttatcatt aattcatcga
    17461 taagtaaacg ctagcatagg gacattctca atcttctgtc ttttgttttt ctcttctttc
    17521 tatgatacaa tggaaaaaat aaattcaaaa ggagtttttt tatgacttat ccaaatctct
    17581 tggaccgctt cttaacctac gttaaggtca acacgcgctc tgatgaacac tctactacta
    17641 ctccaagtac acagagtcag gttgacttcg caacaaatgt cctaattcct gaaatgaaac
    17701 gtgttggact gcaaaatgtt tactatctac cgaatggttt tgctattgga accttgccag
    17761 ccaacgatcc gtctttaaca cgtaagattg gttttatatc gcacatggat actgctgatt
    17821 ttaatgctga aggagtcaat ccacaggtaa ttgaaaacta cgatggtggt gtgattgaac
    17881 tagggaattc tggtttcaaa ctcgatccag ctgacttcaa gagtcttgaa aaatatccag
    17941 gacaaacgct catcacaaca gatggaacaa ccttgctagg tgctgatgac aagtcaggaa
    18001 ttgctgaaat tatgacagcc attgaatatc taactgctca tcctgaaatt aagcactgtg
    18061 agattcgtgt tggttttggt ccagatgaag aaatcggtgt tggtgccaat aaatttgatg
    18121 cagaagattt tgatgtggat tttgcctaca ctgttgatgg tggtccacta ggtgaacttc
    18181 agtacgagac tttctcagcc gctggtgctg aattgcattt ccaaggccgt aatgtccacc
    18241 ctggtactgc caaagggcag atggtcaatg cccttcagct agcaattgat tttcataatc
    18301 aacttccaga aaatgaccga cctgagttaa ctgaaggtta ccaaggtttt taccatctaa
    18361 tggatgtgac aggtagtgtt gaggaggcgc gtgcaagcta catcattcgt gattttgaaa
    18421 aagatgcctt tgaagcgcgt aaagcatcca tgcaatctat cgctgataag atgaatgaag
    18481 aacttgggag cgaccgtgtc actctcaact tgacagacca gtactacaat atgaaagaag
    18541 tcattgaaaa agatatgact ccaattacca ttgctaaagc cgttatggaa gatctaggta
    18601 tcacgcctat tatcgaatca atccggggtg gaacagacgg ctctaagatt tcctttatgg
    18661 gaatcccaac tccgaatatc tttgcaggtg gcgaaaatat gcacggacgt tttgaatacg
    18721 ttagccttca gactatggaa cgtgcagttg ataccatcat tggcatcgta gcttataaag
    18781 gctaaaaaga cgaggtggct cagctacttc gcctttcttt ttattctact ggtttttctt
    18841 gatttccagt agttgtagaa gattctgttg tttcattttc tgaagttgat tcagcaggtt
    18901 tagaatctct tgtattgctt ggtttgtttt cgtcgctagc agtttcaatg ttagattctg
    18961 cagttgcgtt tggttggttc tcagcactgg tgttatcacc atttgcttca gcatttcttg
    19021 ctggacttgt ttcttcactt gcgctagctt ttgactggat ttgatgattc aaaactagaa
    19081 tagcttttgt cggttcaagt aaagctgttt tgtctttact cttagcagaa agttgatcta
    19141 ataatgcatc caccttatca aagtccgcat cagatccatt attactttct aaataagagt
    19201 gaagcgacat gagaatatcg tagagttttt gatagagtac aagtgtctga ggatcttgct
    19261 cagcattttc cttttcttgt tgaagggcgc tagcgatacg agtcaaaaca tcttttacct
    19321 gactgtttac ttcatccaag tctgcatcag ccttgtttgt ggcagctttt agattttcta
    19381 cttcttctgc caaggattgt ctgattcctt cttcatggat ttgttccaag agttgatttg
    19441 ccttgctcaa aagactttct acttcttcct tgctatctgt cgcagattat tggttgccat
    19501 ctaccatgta ctcctaaaac aggagagtta taatccaaga ttacaaggcc ttacagaaat
    19561 aagaaatcca gataagacaa tgttcgtcca agacgctatt cgcttcgcac agcagcacgg
    19621 attcaatatg ctttaatttt aaagtttagg tgtcaagacc tctttttagt gtgcccaaaa
    19681 tttagagaag taatcaatca actaactttt atttttttca aactttcagt aaactgacct
    19741 aaagctaact caatctgtct ttgttcgata ggcttgtctt tgtagatgct tctgctatca
    19801 gctagaagtt gatctacttt tgccaagact gccttctcat aaaaagttcc aggttgatag
    19861 ttggattgca gggatggaat cttgtttttc aaagccgctt catatccctt agtttgaacc
    19921 ttgatgtagt gattgtggtc gccacgagga atcacaaaac cttctgaatc ttcacttata
    19981 attcgattgg catcaaaacc atgaccatct tcttcctcat ggtggacatg tagtgacgga
    20041 ttacttaata cagaactaga agaacttcct accttttccg tgttagagtg tgatggggga
    20101 ttgttaagag atgacttagg aatatagtga tagtgacccc atgtcttact atataagcat
    20161 cacctgtatc tctgacaata tcattagggt taaagacata tgtggctgct aattcacctg
    20221 ccgacaagtc actctcagga atgaaatgat agtgaccacc atgtggtact atagtaggtt
    20281 gaaatagaat atgagcaaat tgataagggg attttaaagt aatttctaac aatgatttag
    20341 aaactatgat gtgctattct aaattcaact cactatatat aaccatcatc ggtagtataa
    20401 cgtccctgta attttgctac agatacttct gcactagctc ctttatcgtc tttaccatgt
    20461 tcttgttttt ggcgattgat ttcatctttt gttcgtacat tttctgcatg agcttgatct
    20521 ttaaggtaaa cataatactt tccatctacc ttaataatat atcctccctt aacctaactg
    20581 acaatatctt gatctttcgg ctgatagttg ggggctttca ttaatggctc ttcactaaag
    20641 agcgcatcaa aaggaacttt accattatag cagtgataat gatcgccatg agaagttaca
    20701 taaccttgac ctgtaatctt aataacaatt tgttttgctt gaattccttc tttttgacta
    20761 acctagtctg gagtcaaatt ttcagtcttc ttagtgtctt tattactgtt tacatatgaa
    20821 acacgatttt tatctgtatt ggcctgttag ctatgttggt tcagagcata aacacacaga
    20881 cttaaggaaa ggataacaac agatccagct gctatatatt tctttttaaa tttcataatt
    20941 acctcatttc tataattatt tatatgatgt cttcattatt aaatgattat agaaattaat
    21001 taaccaatta attaactagt aaatattcca cctcttttta agttgtatgt caagaaattt
    21061 tatatattaa taataaaatg aaattctccc aaagtcagag ttttatttct aacttttgag
    21121 agaacttcat ttttgattca gactttttct actgctattc cttacgctat gagatcagat
    21181 aaattctttt ttatcacttc tccacttggc aatcttaatt caatcgttcc atccatattg
    21241 aatataacac tatctaagcc taatccgtaa ctagctgtaa atttttctaa tttttcttgt
    21301 acaggatcta ctgctggagc ttcctctaat gctgaatcta acatagggtc actccccaca
    21361 ttcccttctg gattcaacat tccattatcc gttgagtttt ctggttttac aggtttttcg
    21421 tttggtgcct ctggtaaaga atctgctggt ttattttctg ttggttggtt ctcaactgtt
    21481 ccagtagata cttttccatt ttcagatggt ttattttcac catttccttg aggtgcttct
    21541 cctgtaaaat ctgccatatt ctttttaatg acttctcccg atggtaaata taattcaatt
    21601 gttccgtcca tattaaacaa gacattttct agcttcatcc cataactttc agcaaatttt
    21661 gctacttttt cttgtacagg atccactgta ggaacttctt ctaacgttga attactagta
    21721 ctattcccag tttcagaaag tttttctttt tctaccttct cactagtctt tggttcttct
    21781 accttttcat caagttttga gttttcttgt gctttattcc ttttaaattg tggtagaata
    21841 cttggtttat cagtttgatt ttctttttcc aagataggta cttccacaat ataagtcgat
    21901 tgattgtcca aataagcatt tgccatgaag gttacaggaa ttttatttcc ggccgttctg
    21961 gttgttcctt ggtttaattt cggaatcggt aatttgattt caccaacttt atagttattt
    22021 tctaaataag catttccatg aaattcatca aacactctga ctaaagcatc agttccttta
    22081 ggcactgcaa attgagggtt cactcttaaa taagtatccc ctgcatggaa aggatagaaa
    22141 atcgtttgac tggccatttt gtaagctaaa gaggttggaa ctgtaaatgt accatcataa
    22201 cttacttctg gataatcttt tgaagcgata gtatacttaa atgtttgtcc tggtaaataa
    22261 ggttgatcta attcaaagtt tgcaatattc cctactcctt ctccaaatac tttaccagat
    22321 actttctcca atacttttcc atctggtgtt attaatttta ctagcatatt gatacctaat
    22381 tttttctcca attcaggcgg aaaactaaaa gaaacgcgtt tttgaccatt ggctagagta
    22441 aagttttgat tattaaacgt actatttttt aacaaattaa caacattcgt taattcttct
    22501 ccagtataaa ctttattccc ttctttttta gcaactcctt cttcgggttt aaacagttca
    22561 tagttactgt gagaatgacc aattccaacc ggtttatgtt catcaatcgg atctgcatga
    22621 tggtgatctc catgcggata aataatcgca tttttttctt tattcacgac aatactttca
    22681 cgtttgacac catattgttt cataatgcca gcaatttttt cttcgatttt tttatctaaa
    22741 tctttcattt ctttggcatt acttggataa tcctgttcat gagatgacaa agaatctaat
    22801 ccattatgac tagttttaac ttcctctaaa tgtttttgcg cagccttaat ttgctcttct
    22861 gtcaagtcct tcttgaagaa ataatgattg tggtctccgt gactcatgac aaaacctgat
    22921 tcatcttcag cgataatacg attagcatca aatccgtatc catcttcttc atgtttctca
    22981 tgtgaagttc ctggattgat tggaagagat ggagaaggtg ttgaagaata gcttaactga
    23041 ctcggttgca tattttttcc agccagatgt gctttagctg ctgctaattc actagcagat
    23101 aaatcgcttt tgggaatgta gtgatagtga cctccatgag gaacgatata agcattaccc
    23161 gtatcttcga taatatcagc tggattaaag acataaccat catttgtcgt atatcgtccc
    23221 tgagaccttg ctacagcaac attagagtta accttctcat tatctttgac atgttcttgt
    23281 ttttgacgat tgatttcatc tttagttcga acattatcag catgagctgc atctttcagg
    23341 tagacataat attttccatc gaccttgatg atataaccac ccttgacttc attgacaata
    23401 tcagcgtctt taagttgata gtttggatcc ttcatcaaga gttcttcact aaagagggca
    23461 tcataaggaa ctttcccatt atagtaatga tagtgatcac cgtgtgacgt tacatagccc
    23521 tgatctgtaa ttttgattac aatttgctca gcctgaattc cttctttctg gctaacctgg
    23581 tctggtgtca agttttcact tttctgactt gactggctgc catccacata agagacacga
    23641 ttattgtcct tattttcctg cgaacgatgc tggtttagtg cataggcaca tagactcaag
    23701 gatacgataa cagctgatcc agctgctata tattttttac taaatttcat aaatccctca
    23761 tttcaataaa tgatgaagtt ttttctcaac ttcttttact ttattaaata gttttctaaa
    23821 ccggttattt aaccatttaa ttaaccagta aatagtttac tatttaaaat tacttttgtc
    23881 aagtttctgt tacgtttttc taaaaaagag aagtaacacg aaaggttact tctcc
//
LOCUS       DAVLHC010000031        21534 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.031, whole genome shotgun sequence.
ACCESSION   DAVLHC010000031 DAVLHC010000000
VERSION     DAVLHC010000031.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 21534)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 21534)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..21534
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.031"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..221
                     /locus_tag="VXE25_001411"
     CDS             <1..221
                     /locus_tag="VXE25_001411"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000523997.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEV0771861.1"
                     /translation="SQYYLEPLYNLLRERLLTQPLLHADETSYRVLESDSQLTYYWTF
                     LSGKAEKQGITLYHHVLIDLFISYFNPL"
     gene            complement(418..1338)
                     /gene="cysK"
                     /locus_tag="VXE25_001412"
     CDS             complement(418..1338)
                     /gene="cysK"
                     /locus_tag="VXE25_001412"
                     /EC_number="2.5.1.47"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000029859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine synthase A"
                     /protein_id="HEV0771862.1"
                     /translation="MSIYNNITELIGQTPIVKLNNIVPEGAADVYIKLEAFNPGSSVK
                     DRIALSMIEKAEQDGILKPGSTIVEATSGNTGIGLSWVGAAKGYKVVIVMPETMSVER
                     RKIIQAYGAELVLTPGSEGMKGAIAKAQEIAAERDGFLPLQFDNPANPEVHERTTGAE
                     ILAAFGKDGLDAFVAGVGTGGTISGVSHALKSENSNIQVFAVEADESAILSGEKPGPH
                     KIQGISAGFIPDTLDTKAYDGIVRVTSDDALALGREIGGKEGFLVGISSAAAIYGAIE
                     VAKKLGTGKKVLALAPDNGERYLSTALYEL"
     gene            complement(1623..2258)
                     /locus_tag="VXE25_001413"
     CDS             complement(1623..2258)
                     /locus_tag="VXE25_001413"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000395753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YigZ family protein"
                     /protein_id="HEV0771863.1"
                     /translation="MEFRTIKEDGQVQEEIKKSRFICHAKRVYSEEEARDFITAIKKE
                     HYKATHNCSAFIIGERSEIKRTSDDGEPSGTAGVPMLGVLENHNLTNVCVVVTRYFGG
                     IKLGAGGLIRAYAGSVALAVKEIGIIEIKEQAGIAIQMSYAQYQEYSNFLKEHDLMEL
                     DTNFTDQIDTMIYVDKEEKETIKAALVEFFNGKVTLTDQGLREVEVPVNLV"
     gene            2314..3612
                     /locus_tag="VXE25_001414"
     CDS             2314..3612
                     /locus_tag="VXE25_001414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000867598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HEV0771864.1"
                     /translation="MKVNLDYLGRLFTENELTEEERQLAEKLPAMRKEKGKLFCQRCN
                     SIILEEWYLPIGAYYCRECLLMKRVRSDQTLYYFPQEDFPKQDVLKWRGQLTPFQEKV
                     SEGLLQAVDKQKPTLVHAVTGAGKTEMIYQVVAKVINAGGAVCLASPRIDVCLELYKR
                     LQQDFSCGIALLHGESEPYFRTPLVVATTHQLLKFYQAFDLLIVDEVDAFPYVDNPML
                     YHAVKNSVKENGLRIFLTATSTNELDKKVRLGELKRLNLPRRFHGNPLIIPKPIWLSD
                     FNRYLDKNRLSPKLKSYIEKQRKTAYPLLIFASEIKKGEQLAEILQEQFPNEKIGFVS
                     SVTEDRLEQVQAFRDGELTILISTTILERGVTFPCVDVFVVEANHRLFTKSSLIQIGG
                     RVGRSMDRPTGDLLFFHDGLNASIKKATKEIQMMNKEAGL"
     gene            3609..4271
                     /locus_tag="VXE25_001415"
     CDS             3609..4271
                     /locus_tag="VXE25_001415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComF family protein"
                     /protein_id="HEV0771865.1"
                     /translation="MKCLLCGQTMKTVLTFSSLLLLRNDDSCLCSDCDSTFERIGEEN
                     CPNCMKTELSTKCQDCQLWCKEGVEVSHRAIFTYNQAMKDFFSRYKFDGDFLLRKVFA
                     SFLSEELKKYKEYQFVVIPLSPDRYANRGFNQVEGLVEAAGFEYLDLLEKREERASSS
                     KNRSERLGTELPFFIKSGVTIPKKILLIDDIYTTGATINRVKKLLEEAGAKDVKTFSL
                     VR"
     gene            4351..4899
                     /gene="raiA"
                     /locus_tag="VXE25_001416"
     CDS             4351..4899
                     /gene="raiA"
                     /locus_tag="VXE25_001416"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000599099.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome-associated translation inhibitor RaiA"
                     /protein_id="HEV0771866.1"
                     /translation="MIKYSIRGENLEVTEAIRDYVVSKLEKIEKYFQPEQELDARINL
                     KVYREKTAKVEVTIPLGSITLRAEDVSQDMYGSIDLVTDKIERQIRKNKTKIERKNKN
                     KVATGQLFTDALVEDSNVVQSKVVRSKQIDLKPMDLEEAILQMDLLGHDFFIYVDVED
                     QTTNVIYRREDGEIGLLEVKES"
     gene            5035..7008
                     /locus_tag="VXE25_001417"
     CDS             5035..7008
                     /locus_tag="VXE25_001417"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DHH family phosphoesterase"
                     /protein_id="HEV0771867.1"
                     /translation="MKKFYVSPIFPILVGLIAFGVLSTFIIFVNNNLLTVLILFLFVG
                     GYVFLFKKLRVHYTRSDVEQIQYVNHQAEESLTALLEQMPVGVMKLNLSSGEVEWFNP
                     YAELILTKEDGDFDLEAVQTIIKASVGNPSTYAKLGEKRYAVHMDASSGVLYFVDVSR
                     EQAITDELVTSRPVIGIVSVDNYDDLEDETSESDISQINSFVANFISEFSEKHMMFSR
                     RVSMDRFYLFTDYTVLEGLMNDKFSVIDAFREESKQRQLPLTLSMGFSYGDGNHDEIG
                     KVALLNLNLAEVRGGDQVVVKENDETKNPVYFGGGSAASIKRTRTRTRAMMTAISDKI
                     RSVDQVFVVGHKNLDMDALGSAVGMQLFASNVIENSYALYDEEQMSPDIERAVSFIEK
                     EGVTKLLSVKDAMGMVTNRSLLILVDHSKTALTLSKEFYDLFTQTIVIDHHRRDQDFP
                     DNAVITYIESGASSASELVTELIQFQNSKKNRLSRMQASVLMAGMMLDTKNFTSRVTS
                     RTFDVASYLRTRGSDSIAIQEIAATDFEEYREVNELILQGRKLGSDVLIAEAKDTKCY
                     DTVVISKAADAMLAMSGIEASFVLAKNTQGFISISARSRSKLNVQRIMEELGGGGHFN
                     LAAAQIKDVTLSEAGEKLTEIVLNEIKEKEKEE"
     gene            7005..7457
                     /gene="rplI"
                     /locus_tag="VXE25_001418"
     CDS             7005..7457
                     /gene="rplI"
                     /locus_tag="VXE25_001418"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L9"
                     /protein_id="HEV0771868.1"
                     /translation="MKVIFLADVKGKGKKGEIKEVPTGYAQNFLIKKNLAKEATAQAV
                     GELRGKQKSEEKAHAEMIAEGKAIKAQLEAEETVVEFVEKVGPDGRTFGSITNKKIAE
                     ELQKQFGIKIDKRHIQVQAPIRAVGLIDVPVKIYQDITSVINLRVKEG"
     gene            7501..8853
                     /gene="dnaB"
                     /locus_tag="VXE25_001419"
     CDS             7501..8853
                     /gene="dnaB"
                     /locus_tag="VXE25_001419"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000852490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replicative DNA helicase"
                     /protein_id="HEV0771869.1"
                     /translation="MAEVEELRVQPQDILAEQSVLGAIFIDESKLVFVREYIESRDFF
                     KYAHRLIFQAMVDLSDRGDAIDATTVRTILDNQGDLQNIGGLSYLVEIVNSVPTSANA
                     EYYAKIVAEKAMLRRLIAKLTESVNQAYEASQPADEIIAQAEKGLIDVSENANRSGFK
                     NIRDVLNLNFGNLEARSQQTTDITGIATGYRDLDHMTTGLHEEELIILAARPAVGKTA
                     FALNIAQNIGTKLDKTVAIFSLEMGAESLVDRMLAAEGLVESHSIRTGQLTDEEWQKY
                     TIAQGNLANASIYIDDTPGIRITEIRSRSRKLAQETGNLGLILIDYLQLITGTGRENR
                     QQEVSEISRQLKILAKELKVPVIALSQLSRGVEQRQDKRPVLSDIRESGSIEQDADIV
                     AFLYRDDYYERGGEEEEGIPNNKVEVIIEKNRSGARGTVELIFQKEYNKFSSISKREA
                     "
     gene            8855..9121
                     /locus_tag="VXE25_001420"
     CDS             8855..9121
                     /locus_tag="VXE25_001420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001278167.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771870.1"
                     /translation="MSDAFTDVAKMKKIKEEIKAHEGQVVEMTLENGRKRQKNRLGKL
                     IEVYPSLFIVEFGDVEGDKQVNVYVESFTYSDILTEKNLIHYLD"
     gene            9210..10556
                     /gene="cbpD"
                     /locus_tag="VXE25_001421"
     CDS             9210..10556
                     /gene="cbpD"
                     /locus_tag="VXE25_001421"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline binding-anchored murein hydrolase CbpD"
                     /protein_id="HEV0771871.1"
                     /translation="MKILPFIARGTSYYLKMSVKKLVPFLVVGLMLAAGDSVYAYSRG
                     NGSIARGDDYPAYYKNGSQEIDQWRMYSRQCTSFVAFRLSNVNGFEIPAAYGNANEWG
                     HRARREGYRVDNTPTIGSITWSTAGTYGHVAWVSNVMGDQIEIEEYNYGYTESYNKRV
                     IKANTMTGFIHFKDLDGGSVGNSQSSASTGGTHYFKTKSAIKTEPLASGTVIDYYYPG
                     EKVHYDQILEKDGYKWLSYTAYNGSYRYVQLEAVNKNPLGNSVLSSTGGTHYFKTKSA
                     IKTEPLVSGTVIDYYYPGEKVHYDQILEKDGYKWLSYTAYNGSRRYIQLEGVTSSQNY
                     QNQSGNISSYGSNNSSTVGWKKINGSWYHFKSNGSKSTGWLKDGSSWYYLKLSGEMQT
                     GWLKENGSWYYLGSSGAMKTGWYQVSGKWYYSYSSGALAVNTTVDGYRVNSDGERV"
     regulatory      10639..10741
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            10812..11102
                     /locus_tag="VXE25_001422"
     CDS             10812..11102
                     /locus_tag="VXE25_001422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000647657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine-binding protein"
                     /protein_id="HEV0771872.1"
                     /translation="MKASIALQVLPLVQGIDRIAVIDQVIAYLQTQEVTMVVTPFETV
                     LEGEFDELMRILKEALEVAGQEADNVFANVKINVGEILSIDEKLEKYTETTH"
     gene            11065..11823
                     /locus_tag="VXE25_001423"
     CDS             11065..11823
                     /locus_tag="VXE25_001423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009013602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEV0771873.1"
                     /translation="MRNLRSILRRHISLLGFLGVLSIWQLAGFLKLLPKFILPTPLEI
                     LQPFVRDREFLWHHSWATLRVALLGLILGVLIACLMAVLMDSLTWLNDLIYPMMVVIQ
                     TIPTIAIAPILVLWLGYGILPKIVLIILTTTFPIIVSILDGFRHCDKDMLTLFSLMRA
                     KPWQILWHFKIPVSLPYFYAGLRVSVSYAFITTVVSEWLGGFEGLGVYMIQSKKLFQY
                     DTMFAIIILVSIISLLGMKLVDISEKYVIKWKRT"
     gene            11861..12868
                     /locus_tag="VXE25_001424"
     CDS             11861..12868
                     /locus_tag="VXE25_001424"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HEV0771874.1"
                     /translation="MKKTWKVFLTLVTALVAVVLVACGQGTASKDNKEAELKKVDFIL
                     DWTPNTNHTGLYVAKEKGYFKEAGVDVDLKLPPEESSSDLVINGKAPFAVYFQDYMAK
                     KLEKGAGITAVAAIVEHNTSGIISRKSDNVSSPKDLVGKKYGTWNDPTELAMLKTLVE
                     SQGGDFEKVEKVPNNDSNSITPIANGVFDTAWIYYGWDGILAKSQGVDANFMYLKDYV
                     KEFDYYSPVIIANNDYLKDNKEEARKVIQAIKKGYQYAMEHPEEAADILIKNAPELKE
                     KRDFVIESQKYLSKEYASDKEKWGQFDAARWNAFYKWDKENGILKEDLTDKGFTNEFV
                     K"
     gene            12868..13596
                     /locus_tag="VXE25_001425"
     CDS             12868..13596
                     /locus_tag="VXE25_001425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0771875.1"
                     /translation="MTEIRLEHVSYAYGQERILEDINLQVTSGEVVSILGPSGVGKTT
                     LFNLIAGILEVQSGRIVLDGEENPKGRVSYMLQKDLLLEHKTVLGNIILPLLIQKVDK
                     AEAISRADKILATFQLTAVRDKYPHELSGGMRQRVALLRTYLFGHKLFLLDEAFSALD
                     EMTKMELHAWYLEIHKQLQLTTLIITHSIEEALNLSDRIYILKNRPGQIVSEIKLDWS
                     EDEDKEVQKIAYKRQILAELGLDK"
     gene            13715..14173
                     /locus_tag="VXE25_001426"
     CDS             13715..14173
                     /locus_tag="VXE25_001426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001211265.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CtsR family transcriptional regulator"
                     /protein_id="HEV0771876.1"
                     /translation="MRFKNTSDHIEAYIKAILDQSGIVELQRSQLADTFQVVPSQINY
                     VIKTRFTESRGYLVESKRGGGGYIRIGRIEFSSHHEMLRELLYSIGERVSQEIYEDIL
                     QLLVEQELMTKQEMNLLESVALDRVLGEEAPVVRANMLRQIIQEVDRKGK"
     gene            14175..16607
                     /locus_tag="VXE25_001427"
     CDS             14175..16607
                     /locus_tag="VXE25_001427"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001109706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit"
                     /protein_id="HEV0771877.1"
                     /translation="MNYSKALNECIESAYMVAGHFGARYLESWHLLIAMSNHSYSVAG
                     ATLNDYPYEMDRLEEVALELTETDYSQDETFTELPFSRRLQVLFDEAEYVASVVHAKV
                     LGTEHVFYAILHDGNALATRILERAGFSYEDKKDQVKIAALRRNLEERAGWTREDLKA
                     LRQRHRTVADKQNSMANMMGMPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRM
                     IQILSRKTKNNPVLVGDAGVGKTALALGLAQRIASGDVPAEMAKMRVLELDLMNVVAG
                     TRFRGDFEERMNNIIKDIEEDGQVILFIDELHTIMGSGSGIDSTLDAANILKPALARG
                     TLRTVGATTQEEYQKHIEKDAALSRRFAKVTIEEPSVADSMTILQGLKATYEKHHRVQ
                     ITDEAVETAVKMAHRYLTSRHLPDSAIDLLDEAAATVQNKAKHVKADDSDLSPADKAL
                     MDGKWKQAAQLIAKEEEVPVYKDLVTESDILTTLSRLSGIPVQKLTQTDAKKYLNLEA
                     ELHKRVIGQDQAVSSISRAIRRNQSGIRSHKRPIGSFMFLGPTGVGKTELAKALAEVL
                     FDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVE
                     KAHPDIFNVLLQVLDDGVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDI
                     RFDQENMEKRMFEELKKAYRPEFINRIDEKVVFHSLSSDHMQEVVKIMVKPLVASLAE
                     KGIDLKLQASALKLLANQGYDPEMGARPLRRTLQTEVEDKLAELLLKGDLVAGNTLKI
                     GVKAGQLKFDIA"
     gene            17249..17902
                     /gene="rr06"
                     /locus_tag="VXE25_001428"
     CDS             17249..17902
                     /gene="rr06"
                     /locus_tag="VXE25_001428"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001024075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system response regulator RR06"
                     /protein_id="HEV0771878.1"
                     /translation="MNILVADDEEMIREGIAAFLTEEGYHVIMAKDGQEVLEKFQDLP
                     IHLMVLDLMMPRKSGFEVLKEINQKHDIPVIVLSALGDETTQSQVFDLYADDHVTKPF
                     SLVLLVKRIKALIRRYYVIEDLWRYQDVTVDFTSYKAHYKNEEIDLKPKELLVLKCLI
                     QHKNQVLSREQILEEISKDVADLPCDRVVDVYIRTLRKKLALDCIVTVKNVGYKISL"
     gene            17899..19239
                     /gene="hk06"
                     /locus_tag="VXE25_001429"
     CDS             17899..19239
                     /gene="hk06"
                     /locus_tag="VXE25_001429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000594665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system sensor histidine kinase
                     HK06"
                     /protein_id="HEV0771879.1"
                     /translation="MIKNPKLLTKSFLRSFAILGGVGLVIHIAIYLTFPFYYIQLEGE
                     KFNESARVFTEYLKTKTSDEIPSLLQSYSKSLTISAHLKRDIVDKRLPLVHDLDIKDG
                     KLSNYIVMLDMSVSTADGKQVTVQFVHGVDVYKEAKNILLLYLPYTFLVTIAFSFVFS
                     YFYTKRLLNPLFYISEVTSKMQDLDDNIRFDESRKDEVGEVGEVGKQINGMYEHLLKV
                     IHELESRNEQIVKLQNQKVSFVRGASHELKTPLASLRIILENMQHNIGDYKDHPKYIA
                     KSINKIDQMSHLLEEVLESSKFQEWTECRETLTVKPVLVDILSRYQELAHSIGVTIEN
                     QLTDATRVVMSLRALDKVLTNLISNAIKYSDKNGRVIISEQDGYLSIKNTCAPLSDQE
                     LEHLFDIFYHSQIVTDKDESSGLGLYIVNNILESYQMDYSFLPYEHGMEFKISL"
     gene            19322..19849
                     /locus_tag="VXE25_001430"
     CDS             19322..19849
                     /locus_tag="VXE25_001430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000241939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isoprenylcysteine carboxyl methyltransferase
                     family protein"
                     /protein_id="HEV0771880.1"
                     /translation="MVLAIILVTFLIRLIFLKRSIENEKRILSNGGKEFGVENTKRLT
                     MAHIVFYLSCLVEAMVHKTIFDSMGMVGLVLLIFSMLMLMLVIHLLGDIWTVKLMLVN
                     NHKYVDHILFRTVKHPNYFLNILPELIGLTLLSHAYMTFVLVFPVYAVILYRRIAEEE
                     KLLHEVIIPNGSIKR"
     gene            19928..>21534
                     /gene="pspC"
                     /locus_tag="VXE25_001431"
     CDS             19928..>21534
                     /gene="pspC"
                     /locus_tag="VXE25_001431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000458116.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal surface protein PspC,
                     choline-binding form"
                     /protein_id="HEV0771881.1"
                     /translation="MFASKSERKVHYSIRKFSIGVASVVVASLFLGGVVHAEEVGGRN
                     TPTVTSSGQDISKKYADEVESHLKKILSEIQTQLDRKRHTETVALINELQGIKKTYLY
                     NLNVLKEKSKVELPSKIKAKLDVAFDQFKKDTLKPGEKVAEAQKKVAEAKKKAEDQKE
                     EDRRNYPTNTYKTLELDIAESDVKVKEAELELVNEEAKPRNEEKIKKAKAKVESEKAE
                     AIRLEEIKTDREEAKRKADAKLKEAVEKNAANSEQGEPKRRVKRGVLGEPATPDKKEN
                     DAKSSDSSVGEETLPSPSLKPEKKVAEAEKKVEEAKKKAEDQKEEDRRNYPTNTYKTL
                     ELEIAESDVKVKEAELELVNEEAKPRNEEKIKKAKAKVESEKAEATRLEKIKTDRKKA
                     EEEAKRKAAEEDKVKEKPAEQPQPAPAPQPEKPAEEPNPAPAPKPEKPADQPKAEKPA
                     DQQAEEDYARRSEEEYNRLTQQQPPKPEQPAPAPKTGWKQENGMWYFYNTDGSMATGW
                     LQNNGSWYYLNSNGAMATGWLQYNGSW"
BASE COUNT         6786 a         3562 c         4897 g         6289 t
ORIGIN      
        1 cgagtcaata ctatttggag cccctttata acctcttgcg agagagacta ttgactcagc
       61 ccttacttca tgcggatgaa acttcttata gggtgctaga gagtgatagt cagctgactt
      121 actattggac ttttttgtct gggaaagctg agaaacaagg gattacgctt taccatcatg
      181 tcctaatcga tttgttcata tcttatttca atccattata aatagtgaga aatatctatc
      241 ctatcttcta gaatgtcttc caaacgtgga aactctcgta aacaaagagg ttttagaggc
      301 ctatttacca tggattaaag ttgtacaaga aaagtgcaaa taagaaatct ccagattagg
      361 aactatccgt gagttctcta gtctggagat ttttcaatat acttcgttat tggacggtta
      421 caattcataa agtgctgtag agagataacg ttcaccgtta tctggtgcta gggcaaggac
      481 ttttttacct gtacctaatt ttttggcaac ctcgatggct ccgtagatag ctgcagctga
      541 ggaaatccct acaaggaagc cttcttttcc accaatttca cgtccgagtg caagagcgtc
      601 atctgatgtt acacgaacga taccatcata ggctttagta tcaagtgtat caggaataaa
      661 tccagctgag ataccttgaa ttttgtgagg accgggtttt tcaccagata gaatagcaga
      721 ttcatctgct tctactgcaa aaacttgaat gttagaattt tctgatttga gtgcatgaga
      781 aacaccagaa atcgttccac cggtacctac tccagcaaca aaggcatcta atccatcttt
      841 accgaaagca gctagtatct cagctcctgt tgttctttcg tgtacttctg gattagctgg
      901 attgtcaaat tgaagaggaa ggaaaccatc acgttcagca gcgatttctt gagccttagc
      961 aatagcacct ttcattccct cgctaccagg agttaggacg agttcagcac cataagcttg
     1021 gataatttta cgtcgttcta cactcatagt ttcaggcata acgatgacga ctttataccc
     1081 tttagcagca cctacccatg aaagtccaat accagtgttt ccacttgttg cttcaacaat
     1141 agtagaacca ggtttcagaa taccatcttg ttcagctttt tcaatcatgc taagggcaat
     1201 acggtctttt acagatgaac caggattaaa tgcttcaagc tttatataga cgtctgcagc
     1261 accttctggc acgatgttgt taagtttaac aattggtgtt tgaccgatta attcagtaat
     1321 gttgttataa atagacatat gaatacctct ttgtataaga tatctttagt ataacgctat
     1381 ctataccatt tgtaaaatat agaaatccta tcgaagcgat aggatttcta tatatcatag
     1441 atcaaagtca ttaattttca agtgattgcg ttcagctaat tctagtaaat aggtgtgaag
     1501 gaaaacgata tcaggtttcg tttgaattgc ttcattttct agtatatttt ggtacgcatc
     1561 tttttatttt gctcgctaaa gtagttgtga gaatgtcaac gaaacgttgt attattcatt
     1621 gtttacacta agtttacagg aacttcaacc tctcgtaaac cttggtcagt taaagtgact
     1681 tttccattaa aaaactccac aagtgcagct ttaatagttt ctttttcttc tttatcaaca
     1741 taaatcatcg tatcgatttg atctgtaaag tttgtatcca gctccatgag atcatgttct
     1801 ttaaggaagt tactgtactc ttggtactga gcataagaca tttgaatagc aatgccagcc
     1861 tgttctttta tttcaataat accaatttct ttgacagcta aggcgacact gccggcgtaa
     1921 gcacgaatta gtcctccagc gcctagttta ataccaccaa agtagcgtgt cacgaccaca
     1981 cagacattgg tgagattgtg attttctagt accccaagca tgggaacacc agcagtacca
     2041 ctaggttcac catcatcact tgtacgttta atttcactac gttctccaat aataaaggca
     2101 gagcagttat gtgtcgcttt gtagtgttct tttttgatgg cagtaatgaa gtcacgagcc
     2161 tcttcttcgc tataaacacg cttggcatgg cagataaagc gagatttttt gatttcttct
     2221 tggacttgac cgtcctcttt aattgttcta aattccatga tttaattgta ctaaaaaatc
     2281 atctaaagtg ctagttttta cgaataaaga agtatgaaag taaatttaga ttatctcggt
     2341 cgtttattta ctgagaatga attaacagaa gaagaacgtc agttggcgga gaaacttcca
     2401 gcaatgagaa aggagaaggg gaaacttttc tgtcaacgct gtaatagtat tattctagaa
     2461 gaatggtatt tgcccatcgg tgcttactat tgtcgagagt gcttgctgat gaagcgagtc
     2521 agaagtgatc aaactttata ctattttccg caggaggatt ttccgaagca agatgttctc
     2581 aaatggcgcg gccaattaac tccttttcaa gagaaggtgt cagagggact gcttcaagca
     2641 gtagacaagc aaaagccaac cttagttcat gcggtaacag gagctggaaa gacagaaatg
     2701 atttatcaag tagtggctaa agtgatcaat gcgggtggtg cagtgtgttt ggctagtcct
     2761 cgcatagatg tttgtttgga gctgtacaag cgcctgcaac aggatttttc ttgcggaata
     2821 gctttgctac atggagaatc ggaaccttat tttcgaacac cactagttgt tgcaacaacc
     2881 catcagttat tgaagtttta tcaagctttt gatttgctga tagtggatga agtagatgct
     2941 tttccttatg ttgataatcc catgctttac cacgctgtca agaatagtgt aaaggagaat
     3001 ggattgagaa tctttttaac agcgacttcg accaatgagt tagataaaaa ggtccgttta
     3061 ggagaactaa aaagactgaa tttaccgaga cggtttcatg gaaatccgtt gattattcca
     3121 aaaccaattt ggttatcgga ttttaatcgc tacttagaca agaatcgttt gtcaccaaag
     3181 ttaaagtcct atattgagaa gcagagaaag acagcttatc cgttactcat ttttgcttca
     3241 gaaattaaga aaggggagca gttagcagaa atcttacagg agcaatttcc aaatgagaaa
     3301 attggctttg tatcttctgt aacagaggat cgattagagc aagtacaagc ttttcgagat
     3361 ggagaactga caatacttat cagtacgaca atcttggagc gtggagttac cttcccttgt
     3421 gtggatgttt tcgtagtaga ggccaatcat cgtttgttta ccaagtctag tttgattcag
     3481 attggtggac gagttggacg aagcatggat agaccgacag gagatttgct tttcttccat
     3541 gatgggttaa atgcttcaat caagaaggcg actaaggaaa ttcagatgat gaataaggag
     3601 gctggtctat gaagtgcttg ttatgtgggc agactatgaa gactgtttta acttttagta
     3661 gtctcttact tctgaggaat gatgactctt gtctttgttc agactgtgat tctacttttg
     3721 aaagaattgg ggaagagaac tgtccaaatt gtatgaaaac agagttgtca acaaagtgtc
     3781 aagattgtca actttggtgt aaagagggag ttgaagtcag tcatagagcg atttttactt
     3841 acaatcaagc tatgaaggat tttttcagtc ggtataagtt tgatggagac ttcctgttaa
     3901 gaaaagtttt cgcttcattt ttaagtgagg agttgaaaaa gtacaaagag tatcaatttg
     3961 ttgtaattcc cctaagtcct gatagatatg ctaatagagg atttaatcag gttgagggct
     4021 tggtagaggc agcaggcttt gagtatctgg atttattaga gaaaagagaa gagagagcca
     4081 gttcttctaa aaatcgttca gagcgcttgg ggacagaact tcctttcttt attaaaagtg
     4141 gagtcactat tcctaaaaaa atcctactta tagatgatat ctatactaca ggagcaacta
     4201 taaatcgtgt taagaaactg ttggaagaag ctggtgctaa ggatgtaaaa acattttccc
     4261 ttgtaagatg aggaaaaaat ttgcaaaaat agaatgaaag cgttataata aaatcataaa
     4321 aacaaaaatg tttagaaaga aggtactcat atgattaaat atagtatccg tggtgaaaac
     4381 ctagaagtaa cagaagcaat tcgtgattat gtagtttcta aactcgaaaa gatcgaaaag
     4441 tacttccaac cagaacaaga gttggatgcc cgaattaact taaaagttta tcgtgaaaaa
     4501 acggctaaag tggaagtaac gattccgctt ggatctatta ctctccgcgc agaagatgta
     4561 tctcaagata tgtatggttc aattgacctt gtaactgata aaattgaacg tcagattcgt
     4621 aaaaataaaa caaaaatcga gcgtaaaaat aaaaataagg tagcaactgg tcaattattt
     4681 acagatgctt tggtggaaga ttcaaatgtt gtccagtcta aagttgttcg ttcaaaacaa
     4741 attgatttaa aaccaatgga tttggaagaa gcaattctac aaatggattt attggggcat
     4801 gatttcttta tctatgtgga tgttgaagat cagacaacca atgtgattta tcgtcgtgag
     4861 gatggcgaaa ttggtttgtt agaggttaaa gaatcttaat ttcaatatgt gtaaaggtag
     4921 gtttactgaa ttgtaaacta cctttttctt ataattgata gaattactga ttacactttt
     4981 aaaaagtcgc tttttgaggg gtattatggt ataatgggtg ccaagaggtt ttgaatgaaa
     5041 aaattttatg taagtccaat ttttcctatt ctagtaggat tgattgcgtt tggagtctta
     5101 tccactttca ttatttttgt taataataat ctgttgacgg ttttaatttt gtttcttttt
     5161 gtaggaggct atgttttttt atttaagaaa ctgagagtgc attatacaag gagtgatgta
     5221 gaacagatac agtatgtaaa ccaccaagcg gaagaaagtt tgacagctct attggaacag
     5281 atgcctgtag gtgttatgaa attgaattta tcttctggag aggttgagtg gtttaatccc
     5341 tatgctgaat tgattttgac caaggaagat ggtgattttg atttagaagc tgttcaaacg
     5401 attatcaagg cttcagtagg aaatccgtct acttatgcca agcttggtga gaagcgttat
     5461 gctgttcata tggatgcttc ttccggtgtt ttgtattttg tagatgtatc cagggaacaa
     5521 gccataacag atgaattggt aacaagtaga ccagtgattg ggattgtctc tgtggataat
     5581 tatgatgatt tggaggatga aacttctgag tcagatatta gtcaaatcaa tagttttgta
     5641 gctaatttta tatcagagtt ttcagaaaaa cacatgatgt tttctcgtcg ggtaagtatg
     5701 gatcgatttt atctatttac tgactacacg gtgcttgagg gcttgatgaa tgataaattt
     5761 tctgttattg atgctttcag agaagagtcg aaacagagac agttgccctt gaccttaagt
     5821 atgggatttt cttatggcga tggaaatcat gatgagatag ggaaagttgc tttgctcaat
     5881 ttgaacttgg ctgaagtacg tggtggcgac caggtggttg ttaaggaaaa cgacgaaacg
     5941 aaaaatccag tttattttgg tggtgggtct gctgcttcaa tcaagcgtac acggactcgt
     6001 acgcgcgcta tgatgacagc tatttcagat aagattcgga gtgtagatca ggtttttgta
     6061 gtcggtcaca aaaatttaga catggatgct ttgggctctg ctgtaggtat gcagttgttc
     6121 gccagcaatg tgattgaaaa tagctatgct ctttatgatg aagaacaaat gtctccagat
     6181 attgaacgag ctgtttcatt catagaaaaa gaaggagtta cgaagttgtt gtctgttaag
     6241 gatgcaatgg ggatggtgac caatcgttct ttgttgattc ttgtagacca ttcaaagaca
     6301 gccttaacat tatcaaaaga attttatgat ttatttaccc aaaccattgt tattgaccac
     6361 catagaaggg atcaggattt tccagataat gcggttatta cttatatcga aagtggtgca
     6421 agtagtgcca gtgagttggt aacggaattg attcagttcc agaattctaa gaaaaatcgt
     6481 ttgagtcgta tgcaagcaag tgttttgatg gctggtatga tgttggatac taaaaatttc
     6541 acctcgcgag taactagtcg gacatttgat gttgctagct atctcagaac gcgcggaagt
     6601 gatagtattg ctatccagga aatcgctgcg acagattttg aagaatatcg tgaggtcaat
     6661 gaacttattt tacaggggcg taaattaggt tcagatgtac taatagcaga ggctaaggac
     6721 acgaaatgct atgatacagt tgttattagt aaggcagcag atgccatgtt agccatgtca
     6781 ggtattgaag cgagttttgt tcttgcgaag aatacacaag gatttatctc tatctcagct
     6841 cgaagtcgta gtaaactgaa tgtacaacgg attatggaag agttaggcgg tggaggccac
     6901 tttaatttgg cagcagctca aattaaagat gtaaccttgt cagaagcagg tgaaaaactg
     6961 acagaaattg tattaaatga aataaaggaa aaggagaaag aagaatgaaa gtaatctttt
     7021 tagcagatgt taaaggaaaa ggtaaaaaag gcgaaattaa ggaagtacca acagggtatg
     7081 cgcaaaactt tcttatcaaa aagaatctag ccaaagaagc gactgctcaa gctgtaggtg
     7141 aacttcgagg taaacaaaaa tcggaagaaa aagctcacgc tgagatgatt gcagaaggaa
     7201 aagcaattaa agcacaactt gaagcagaag aaactgttgt agaatttgtt gaaaaagttg
     7261 gtccagatgg tcgtaccttt ggttctatta ccaataagaa gattgcagaa gaattgcaaa
     7321 agcaatttgg aattaagatt gataaacgtc atattcaagt acaagctccg attcgagcgg
     7381 ttggtttgat tgatgtgcca gtgaaaatct atcaagatat cacaagtgta atcaatcttc
     7441 gtgtgaaaga aggataagtt tacactttct tgacaagatt gtaaaaggaa gggaagtctg
     7501 atggcagaag tagaagagtt acgagtacaa cctcaagata tcttagctga gcaatccgtt
     7561 ttaggggcta tctttattga tgagagtaaa cttgtttttg tgcgagaata cattgagtct
     7621 cgggactttt ttaagtatgc ccatcgtttg attttccaag ccatggtcga tttatccgat
     7681 cgtggtgatg ccatagatgc aacaacggtt cgtactatcc ttgataatca aggtgattta
     7741 cagaatattg gtggcttgtc ttacttggtt gagattgtta attctgtgcc aacttctgct
     7801 aatgcggagt attatgctaa gattgttgca gaaaaagcaa tgctacgtcg tttaattgcc
     7861 aagttgacag agtctgtcaa ccaagcttac gaagcgtcac aaccagctga tgaaattatt
     7921 gctcaggcag aaaaagggct gattgatgtc agtgaaaatg caaatcgaag cgggtttaag
     7981 aacattcgag atgtgttgaa tctcaacttt ggaaatctgg aagctcgctc gcaacaaacg
     8041 accgatatta caggtattgc gacaggttat cgtgatttgg atcatatgac aacaggactt
     8101 catgaggagg agttgattat cttagcagct cgtccagcag ttggtaagac agcatttgcc
     8161 ttgaatatcg ctcagaacat tgggactaag ttggacaaaa cggttgctat tttttcactc
     8221 gaaatgggtg cggaaagctt ggtagatcgt atgttagctg cagaaggctt agtggagtca
     8281 cattctatcc gtacagggca attgacagat gaggagtggc aaaaatatac tattgctcag
     8341 ggtaatctag ctaacgccag tatctatatc gatgatacgc caggtattcg gattacagag
     8401 attcgttctc gttctcgtaa attggctcaa gaaactggaa atcttggttt gattttgata
     8461 gactatttgc aacttatcac gggaactggt cgagaaaatc gtcaacaaga agtttctgaa
     8521 atttctcgtc agttgaaaat actagccaag gaattgaagg ttccagtaat cgctctgagt
     8581 cagctttctc gtggtgtaga acaacgtcag gacaagagac cggtcttgtc tgatattcgt
     8641 gaatctgggt ctattgagca ggacgctgat atcgtagctt ttctctatcg cgatgactac
     8701 tatgaacgtg gtggtgaaga agaggagggt atcccaaata ataaggtgga agttattatc
     8761 gagaaaaacc gtagtggagc tcgtggaaca gtggaattga ttttccaaaa agaatacaat
     8821 aaattttcaa gtatctcaaa gagggaggca taagatgtca gatgcattta cagatgtagc
     8881 caagatgaaa aaaatcaaag aagaaatcaa ggcacatgag ggacaagtcg tagaaatgac
     8941 tttggagaat ggtcgtaagc gccaaaaaaa tagattgggt aagctaattg aagtttatcc
     9001 atctctattt attgtggagt ttggggatgt ggaaggagat aaacaagtta atgtttacgt
     9061 tgaatccttt acttactcag atattcttac agaaaagaat ttgattcatt atcttgacta
     9121 aagtgagaaa ttttctcact ttttcttttt tctccgaata atttaggtga aggcaatcat
     9181 cgctttatat tatttttcaa ggaggaagaa tgaaaatttt accgtttata gcaagaggaa
     9241 caagttatta cttgaagatg tcagttaaaa agcttgttcc ttttttagta gtaggattga
     9301 tgctagcagc tggtgatagt gtctatgcct attccagagg aaatggatcg attgcgcgtg
     9361 gggatgatta tcctgcttat tataaaaatg ggagccagga gattgatcag tggcgcatgt
     9421 attctcgtca gtgtacttct tttgtagcct ttcgtttgag taatgtcaat ggttttgaaa
     9481 ttccggcagc ttatggaaat gcgaatgaat ggggacatcg tgctcgtcgg gaaggttatc
     9541 gtgtagataa tacaccgacg attggttcca ttacttggtc tactgcagga acttatggtc
     9601 atgttgcctg ggtgtcaaat gtaatgggag atcagattga gattgaggaa tataactatg
     9661 gttatacaga atcctataat aaacgagtta taaaagcaaa cacgatgaca ggatttattc
     9721 attttaaaga tttggatggc ggcagtgttg ggaatagtca atcctcagct tcaacaggcg
     9781 gaactcatta ttttaagacc aagtctgcta ttaaaactga acccctagct agcggaactg
     9841 tgattgatta ctattatcct ggggagaagg ttcattatga tcagatactt gaaaaagacg
     9901 gctataagtg gttgagttat actgcctata atggaagcta tcgttatgtt caattggagg
     9961 ctgtgaataa aaatcctcta ggtaattctg ttctttcttc aacaggtgga actcattatt
    10021 ttaagaccaa gtctgctatc aaaactgaac ccctagttag cggaactgtg attgattact
    10081 attatcctgg ggagaaggtt cattatgatc agatacttga aaaagacggc tacaagtggt
    10141 tgagttatac tgcctataat ggaagtcgtc gctatataca gctagaggga gtgacttctt
    10201 cacaaaatta tcagaatcaa tcaggaaata tctctagcta tggatccaat aatagttcaa
    10261 ctgtcggttg gaagaaaata aatggtagtt ggtatcattt caaatcaaat ggttctaaat
    10321 caacaggatg gctgaaagac ggttctagct ggtattattt gaaattatct ggtgaaatgc
    10381 agacaggatg gttaaaggaa aatggctcgt ggtattatct gggtagttca ggggcaatga
    10441 aaacaggctg gtaccaggtc tctggtaagt ggtattattc ttactcttca ggcgccttag
    10501 ctgttaatac gacggtggat ggctacagag taaacagtga tggagaacga gtatagaaaa
    10561 ttggagtagg agaaatttcc tgctcttttc tgtaagcagt ttccttgaca tttttcttat
    10621 tttgcgctat catatataca tataatatat gggagtctgt gtacagtctg agaggaagtg
    10681 ttaaacttcg accgcacctg atctgggtaa tgccagcgga gggaacgata cttagtctaa
    10741 ttttgcacct tttccatgta tggtaaaggt ttttcttttt ttaaaaagga aaacgagaag
    10801 aggaggttct tatgaaagca agcattgcct tgcaagtttt acccctagta caggggattg
    10861 atcggatagc tgttattgat caggtcattg cttatctgca aactcaagaa gtgacgatgg
    10921 tagtgacacc atttgaaacg gtcttggaag gggagtttga tgagcttatg cgcattctaa
    10981 aagaagcgct ggaagtggca gggcaggagg cagacaatgt ctttgccaat gtcaaaataa
    11041 atgtaggaga gattttaagt attgatgaga aacttgagaa gtatactgag acgacacatt
    11101 agtctattgg gctttctcgg agtattgtca atctggcagt tagcaggttt tcttaaactt
    11161 ctccccaagt ttatcctgcc gacacctctt gaaattctcc agccctttgt tcgtgacaga
    11221 gaatttctct ggcaccatag ctgggcgacc ttgagagtgg ctttactggg gctgattttg
    11281 ggagttttga ttgcctgtct tatggctgta ctcatggata gtttgacttg gctcaatgac
    11341 ctgatttacc ctatgatggt ggtcattcag accattccga ccattgccat agctcctatc
    11401 ctggtcttgt ggctaggtta tgggattttg cccaagattg tcttgattat cttaacgaca
    11461 acctttccca tcatcgtcag cattttggac ggttttaggc attgcgacaa ggatatgctg
    11521 actttgttta gtctgatgcg ggccaagcct tggcaaatcc tgtggcattt taaaatcccg
    11581 gttagcctgc cttactttta tgcaggtctg agggtcagtg tctcctacgc ctttatcaca
    11641 actgtggtat ctgagtggtt gggaggtttt gaaggtcttg gtgtttatat gattcagtct
    11701 aaaaaactgt ttcagtatga taccatgttt gccattatta ttctggtgtc gattatcagt
    11761 cttttgggta tgaagctggt cgatattagt gaaaaatatg ttattaaatg gaaacgtact
    11821 taaaatagag cgtttttgaa aaagaaaaga ggaaatcaaa atgaagaaaa catggaaagt
    11881 gtttttaacg cttgtaacag ctcttgtagc tgttgtgctt gtggcctgtg gtcaaggaac
    11941 tgcttctaaa gacaacaaag aggcagaact taagaaggtt gactttatcc tagactggac
    12001 accaaatacc aaccacacag ggctttatgt tgccaaggaa aaaggttatt tcaaagaagc
    12061 tggagtggat gttgatttga aattgccacc agaagaaagt tcttctgact tggttatcaa
    12121 cggaaaggca ccatttgcag tgtatttcca agactacatg gctaagaaat tggaaaaagg
    12181 agcaggaatc actgccgttg cagctattgt tgaacacaat acatcaggaa tcatctctcg
    12241 taaatctgat aatgtaagca gtccaaaaga cttggttggt aagaaatatg ggacatggaa
    12301 tgacccaact gaacttgcta tgttgaaaac cttggtagaa tctcaaggtg gagactttga
    12361 gaaggttgaa aaagtaccaa ataacgactc aaactcaatc acaccgattg ccaatggcgt
    12421 ctttgatact gcttggattt actacggttg ggatggtatc cttgctaaat ctcaaggtgt
    12481 agatgctaac ttcatgtact tgaaagacta tgtcaaggag tttgactact attcaccagt
    12541 tatcatcgca aacaacgact atctgaaaga taacaaagaa gaagctcgca aagtcatcca
    12601 agccatcaaa aaaggctacc aatatgccat ggaacatcca gaagaagctg cagatattct
    12661 catcaagaat gcacctgaac tcaaggaaaa acgtgacttt gtcatcgaat ctcaaaaata
    12721 cttgtcaaaa gaatacgcaa gcgacaagga aaaatggggt caatttgacg cagctcgctg
    12781 gaatgctttc tacaaatggg ataaagaaaa tggtatcctt aaagaagact tgacagacaa
    12841 aggcttcacc aacgaatttg tgaaataatg acagaaatta gactagagca cgtcagttat
    12901 gcctatggtc aggagaggat tttagaggat atcaacctac aggtgacttc aggcgaagtg
    12961 gtttccatcc taggcccaag tggtgttgga aagaccaccc tctttaatct aatcgctggg
    13021 attttagaag ttcagtcagg gagaattgtc cttgatggtg aagaaaatcc caaggggcgc
    13081 gtgagttata tgttgcaaaa ggatctgctc ttggagcaca agacggtgct tggaaatatc
    13141 attctgcccc tcttgattca aaaggtggat aaggcagaag ctatttcccg agcggataaa
    13201 attcttgcga ccttccagct gacagctgta agagacaagt atcctcatga acttagcggt
    13261 gggatgcgcc agcgtgtagc cttactccgg acctaccttt ttgggcacaa gctctttctc
    13321 ttagatgagg cctttagcgc cttggatgag atgacaaaga tggaactcca cgcttggtat
    13381 cttgagattc acaagcagtt gcagctaaca accctgatca tcacgcatag tattgaggag
    13441 gccctcaatc tcagcgaccg catctatatc ttgaaaaatc gccctgggca gattgtttca
    13501 gaaattaaac tagattggtc tgaagatgag gacaaggaag tccaaaagat tgcctacaaa
    13561 cgtcaaatct tggcagaatt aggcttagat aagtagaaaa atagggagtt ggtgaagatt
    13621 atcctttacc agcgcccttt ttcttttaaa aatgagaaaa tttcggtata atagtcaaac
    13681 aaggtcaagg tttaaagaga gaggtgggtt tgttatgaga tttaaaaata catcggatca
    13741 tattgaggcc tacatcaagg cgattttaga tcaatctggt atcgtggagt tgcaacggag
    13801 tcagttggca gatacctttc aggttgttcc tagtcagatt aactacgtga tcaagacacg
    13861 ctttacggaa agtagaggct acttggttga aagtaagcgt ggtggcggag gctacattcg
    13921 tataggacgg attgagtttt ctagtcatca tgaaatgctc cgggagctgc tttactcgat
    13981 tggtgagcga gtcagtcaag aaatttatga ggatattctc cagcttttgg ttgagcagga
    14041 attgatgacc aagcaggaga tgaatttgct agaatcagta gctttggatc gcgttttagg
    14101 agaagaagct ccagttgttc gagcaaacat gctacgtcag atcatacaag aggtagatag
    14161 aaaagggaag taagatgaac tattcaaaag cattgaatga atgtatcgaa agtgcctaca
    14221 tggttgctgg acattttgga gctcgttatc tagagtcttg gcacttgttg attgccatgt
    14281 ctaatcacag ttatagtgta gcaggggcaa ctttaaatga ttatccgtat gagatggacc
    14341 gtttagaaga ggtggctttg gaactgactg aaacggacta tagccaggat gaaaccttta
    14401 cggaattgcc gttctcccgt cgtttgcagg ttctttttga cgaagcagag tatgtagcgt
    14461 cagtggtcca tgctaaggtg ctagggacag agcacgtctt ctatgcgatt ttgcatgatg
    14521 gcaatgcctt ggcaactcgt atcttggaga gggctggttt ttcttatgaa gacaagaaag
    14581 atcaggtcaa gattgctgcc cttcgtcgaa atttagaaga acgggcaggc tggactcgtg
    14641 aagacctcaa ggctttacgc caacgccatc gtacagtagc tgacaagcaa aattctatgg
    14701 ccaatatgat gggcatgccg cagactccta gtggtggtct tgaggactat acgcatgatt
    14761 tgacagagca agcgcgttct ggcaagttag aaccagtcat cggtcgggac aaggaaatct
    14821 cacgtatgat tcaaattttg agccgtaaga ctaagaacaa ccctgtcttg gttggggatg
    14881 ctggtgtcgg gaaaacagct ctggcccttg gtcttgccca gcgtattgct agtggtgacg
    14941 tgcctgcgga aatggctaag atgcgcgtgt tagaacttga tttgatgaat gtcgttgcag
    15001 ggacacgctt ccgtggtgac tttgaagaac gcatgaataa tatcatcaag gatattgaag
    15061 aagatggcca agtcatcctc tttatcgatg aactccacac catcatgggt tctggtagcg
    15121 ggattgattc gactctggat gcggccaata tcttgaaacc agccttggcg cgtggaactt
    15181 tgagaacggt tggtgccacc actcaggaag aatatcaaaa acatatcgaa aaagatgcgg
    15241 ctctttctcg tcgtttcgct aaagtgacga ttgaagaacc aagtgtggca gatagtatga
    15301 ctattttaca aggtttgaag gcgacttatg agaaacatca ccgtgtacaa atcacagatg
    15361 aagcggttga aacagcggtt aagatggctc atcgttattt aaccagtcgt cacttgccag
    15421 actctgctat cgacctcttg gacgaagcag cagcaacagt gcaaaataag gcaaagcatg
    15481 taaaagcaga cgattcagat ttgagtccag ctgacaaggc cctgatggat ggcaagtgga
    15541 aacaggcagc ccagctaatc gcaaaagaag aggaagtacc tgtctacaaa gacttggtga
    15601 cagagtctga tattttgacc accttgagtc gcttgtcagg aatcccagtt caaaaactga
    15661 ctcaaacgga tgctaagaag tatttaaatc ttgaagcaga actccataaa cgtgtcatcg
    15721 gtcaagatca agctgtttca agtattagtc gtgccattcg ccgtaatcag tcaggaattc
    15781 gcagtcacaa gcgtccgatc ggttccttta tgttcctagg acccacaggt gtcggtaaga
    15841 ccgagttggc caaggctttg gcagaagttc tctttgatga cgaatcagcc cttatccgct
    15901 ttgatatgag tgagtatatg gagaaattcg cagccagccg tctaaatgga gctcctccag
    15961 gctatgtggg ttacgaagaa ggtggggagc tgacagagaa ggttcgcaat aaaccctatt
    16021 ccgttctcct ctttgatgag gtagagaagg cccacccaga tatctttaat gttctcttgc
    16081 aggttctgga tgacggtgtc ttgacagata gcaagggacg caaggtcgat ttttcaaata
    16141 ccattatcat tatgacatcg aatctaggtg cgactgccct tcgtgatgat aagactgttg
    16201 gttttggggc taaggatatt cgttttgacc aggaaaatat ggaaaaacgc atgtttgaag
    16261 aactgaaaaa agcttataga ccggaattca tcaaccgcat tgatgagaag gtggtcttcc
    16321 atagcctatc tagtgaccat atgcaggaag tggtgaagat tatggtcaag cctttagtgg
    16381 caagtttggc tgaaaaaggc attgacttga aattacaagc ttcagctctg aaattgttag
    16441 caaatcaagg atatgaccca gagatgggag ctcgcccact tcgcagaacc ctgcaaacag
    16501 aagtggagga caagttggca gaacttcttc ttaagggaga tttagtggca ggcaacacac
    16561 ttaagattgg tgtcaaagca ggccagttaa aatttgatat tgcataaaag aataaaagta
    16621 tcagcatctg accataagtc acagtggagt gaaactcaat gaaaatcaaa gagcaaacta
    16681 ggcagctagc tgcaggttgc tcaaaacact gttttgaggt tgcagataga gctgacgtgg
    16741 tttgaagaga ttttcgaaga gtatgaaact aaaacctata gcttctaaac gatccgtggt
    16801 tttcaccatt caacacaaaa ttcatatgtt tattaccctc cgtcgtattt gtcttagagc
    16861 gtgtgtagta gaaaaagagc agtcttatct gaaattttta ttctttcaaa agagacctgt
    16921 ttcttttttg catgtcaaat ccgttctagc tggtatttga aaaatcaaac taatattcaa
    16981 tgaaaatcaa agaacaaact aggaagctag ccgcaggttg ctcaaaacac tgttttgagg
    17041 ttgtagatag agctgacgtg gtttgaagag attttcgaag agtataagct gcaagatgaa
    17101 tgattttctt gtattgacgt tgttgttgac aaaaagtagc ggataaatga aatccattcc
    17161 attatcatag atgataggct ggtaggaaat tttcaaatag catacaggaa atagatgtat
    17221 ggagttctgg tagtagaaag ggagagagat gaacatttta gttgcagatg acgaggaaat
    17281 gattagagaa ggaattgcag catttctgac agaagagggt tatcatgtca ttatggctaa
    17341 ggatggacaa gaggtcttgg aaaaatttca agatctccct atccatctca tggtactgga
    17401 tttaatgatg cctaggaaga gtggttttga agtgttaaaa gaaatcaatc aaaagcacga
    17461 tattcctgtc atcgtcttga gtgctctggg agatgaaact actcagtcac aggtatttga
    17521 tctctatgct gatgatcatg tgacaaaacc tttttctttg gtactgcttg tcaagcgtat
    17581 taaggcgctt atcagacgtt actacgtcat agaggatctt tggcgatatc aggatgtaac
    17641 agtggatttt acctcttaca aagcacatta taaaaatgaa gaaattgatc tcaaaccaaa
    17701 ggaattactg gtactaaagt gtttgattca gcataaaaat caagttttaa gtagagagca
    17761 gatattggaa gaaatttcaa aagatgtagc tgatttacct tgtgataggg tcgttgatgt
    17821 ctatattcgt actcttcgca aaaaattagc tttagattgt atcgtgactg tgaaaaatgt
    17881 tgggtataag attagcttat gataaaaaat cctaaattat taaccaagtc ttttttaaga
    17941 agttttgcaa ttctaggtgg tgttggtcta gtcattcata tagctattta tttgaccttt
    18001 cctttttatt atattcaact ggagggggaa aagtttaatg agagcgcaag agtgtttacg
    18061 gagtatttaa agactaagac atctgatgaa attccaagct tactccagtc ttattcaaag
    18121 tccttgacca tatctgctca ccttaaaaga gatattgtag ataagcggct ccctcttgtg
    18181 catgacttgg atattaaaga tggaaagcta tcaaattata tcgtgatgtt agatatgtct
    18241 gttagtacag cagatggtaa acaggtaacc gtgcaatttg ttcacggggt agatgtctac
    18301 aaagaagcaa agaatatttt gcttttgtat ctcccatata catttttggt tacaattgct
    18361 ttttcctttg ttttttctta tttttatact aaacgcttgc tcaatcctct tttttacatt
    18421 tcagaagtga ctagtaaaat gcaagatttg gatgacaata ttcgttttga tgaaagtagg
    18481 aaagatgaag ttggtgaagt tggtgaagtt ggaaaacaga ttaatggtat gtatgagcac
    18541 ttgttgaagg ttattcatga gttggaaagt cgtaatgagc aaattgtaaa attgcaaaat
    18601 caaaaggttt cctttgtccg cggagcatca catgagttga aaaccccttt agccagtctt
    18661 agaattatcc tagagaatat gcagcataat attggagatt acaaagatca tccaaaatat
    18721 attgcaaaga gtataaataa gattgaccag atgagccact tattggaaga agtactggag
    18781 tcttctaaat tccaagagtg gacagagtgt cgtgagacct tgactgttaa gccagtttta
    18841 gtagatattt tatcacgtta tcaagaatta gctcattcaa taggtgttac aattgaaaat
    18901 caattgacag atgctaccag ggtcgtcatg agtcttaggg cattggataa ggttttgaca
    18961 aacctgatta gtaatgcaat taaatattca gataaaaatg ggcgcgtaat catatccgag
    19021 caagatggct atctctctat caaaaataca tgtgcgcctc taagtgacca agaactagaa
    19081 catttatttg atatattcta tcattctcaa atcgtgacag ataaggatga aagttccggt
    19141 ttgggtcttt acattgtgaa taatatttta gaaagctatc aaatggatta tagttttctc
    19201 ccttatgaac acggtatgga atttaagatt agcttgtaga cagattagtt ttttattaaa
    19261 gttcatatag ggttaacata agtgtgttat tctttgtgta gataaaagaa aggatactaa
    19321 tatggtatta gcgattattt tagtaacatt ccttattcga ttgatttttt taaagcgttc
    19381 gatagagaat gagaaacgaa tccttagcaa tggcgggaaa gaatttggag ttgagaatac
    19441 aaaacgatta actatggctc atattgtttt ttatctctct tgcttggttg aggcaatggt
    19501 gcacaagaca atttttgata gcatgggcat ggttggttta gtcttgctta ttttttctat
    19561 gctgatgtta atgttggtga ttcacttgtt gggagatatt tggacagtga agcttatgct
    19621 tgtcaataat cacaaatatg tagatcatat cttgtttagg acagtaaaac atcctaatta
    19681 ctttttaaat attcttcctg agttgattgg cttgaccttg ttgagtcatg cctatatgac
    19741 ttttgtttta gtttttccag tttatgcagt tattttgtat cgacgaatag ctgaagagga
    19801 aaagctatta catgaagtta taatcccaaa tggaagcata aagagataaa tacaaaattc
    19861 gatttatata cagttcatat tgaagtgata tagtaaggtt aaagaaaaaa tatagaagga
    19921 aataaacatg tttgcatcaa aaagcgaaag aaaagtacat tattcaattc gtaaatttag
    19981 tattggagta gctagtgtag tagttgctag cttgttctta ggaggagtag ttcatgcaga
    20041 agaggttggt ggtaggaata cccccacggt tacatctagt gggcaagata tatcgaagaa
    20101 gtatgctgat gaagtcgagt cgcatctaaa aaaaatattg agtgagatcc aaacacaatt
    20161 agatagaaaa cgacataccg aaactgtagc gctaattaac gagttgcaag gcattaagaa
    20221 aacgtatttg tataatttaa atgttttaaa agagaagtcg aaagttgagt tgccgtcaaa
    20281 aataaaagca aagttagacg tagcttttga tcagtttaaa aaagatacat tgaaaccagg
    20341 agaaaaggta gcagaagctc agaagaaagt tgcagaagct aagaaaaaag ccgaggatca
    20401 aaaagaagaa gatcgccgta actacccaac caatacttac aaaacgcttg aacttgacat
    20461 tgctgagtcc gatgtgaaag ttaaagaagc ggagcttgaa ctagtaaacg aggaagctaa
    20521 acctcgaaac gaggaaaaaa ttaagaaagc aaaagcgaaa gttgagagtg aaaaagctga
    20581 ggctataagg ttagaagaaa tcaagacaga tcgtgaagaa gctaaacgaa aagcagatgc
    20641 taagttgaag gaagctgttg aaaagaatgc agcgaattca gagcaaggtg aaccaaagag
    20701 gcgggtaaaa cgaggagttc ttggagagcc agcaacacct gataaaaaag aaaatgatgc
    20761 gaagtcttca gattctagcg taggtgaaga aactcttcca agcccatccc tgaaaccaga
    20821 aaaaaaggtt gcagaagctg agaagaaggt tgaagaagct aagaaaaaag ccgaggatca
    20881 aaaagaagaa gatcgccgta actacccaac caatacttac aaaacgcttg aacttgaaat
    20941 tgctgagtcc gatgtgaaag ttaaagaagc ggagcttgaa ctagtaaacg aggaagctaa
    21001 acctcgaaac gaggaaaaaa ttaagaaagc aaaagcgaaa gttgagagtg aaaaagctga
    21061 ggctacaagg ttagaaaaaa tcaagacaga tcgtaaaaaa gcagaagaag aagctaaacg
    21121 aaaagcagca gaagaagata aagttaaaga aaaaccagct gaacaaccac aaccagcgcc
    21181 ggctcctcaa ccagaaaaac cagctgaaga gcctaatcca gctccagctc caaaaccaga
    21241 gaagccagct gatcaaccaa aagcagaaaa accagctgat caacaagctg aagaagacta
    21301 tgctcgtaga tcagaagaag aatataatcg cttgactcaa cagcaaccgc caaaaccaga
    21361 gcaaccagct cctgcaccaa aaacaggctg gaaacaagaa aacggtatgt ggtacttcta
    21421 caatactgat ggttcaatgg cgacaggatg gctccaaaac aatggctcat ggtactacct
    21481 caacagcaat ggcgctatgg cgacaggatg gctccaatac aatggttcat ggta
//
LOCUS       DAVLHC010000032        20531 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.032, whole genome shotgun sequence.
ACCESSION   DAVLHC010000032 DAVLHC010000000
VERSION     DAVLHC010000032.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 20531)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20531)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20531
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.032"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..201
                     /locus_tag="VXE25_001432"
     CDS             <1..201
                     /locus_tag="VXE25_001432"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771882.1"
                     /translation="RLFDTSTLMKRRIFFLFALDVIAYLFLGYLLVIQKAGYLFSVLL
                     LFSNFSVPFIKAKEYELFKNSK"
     gene            1334..1573
                     /locus_tag="VXE25_001433"
     CDS             1334..1573
                     /locus_tag="VXE25_001433"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000770310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771883.1"
                     /translation="MKLLDCILDYQERFNGKTCQVSTNYKYLEIFKVNFCLTDLHHLF
                     DLYKITRDYASQTKPAIQAGVFILEDFRNILCTMM"
     gene            1558..1836
                     /locus_tag="VXE25_001434"
     CDS             1558..1836
                     /locus_tag="VXE25_001434"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002206150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771884.1"
                     /translation="MYNDVIERISLYEFIGDIFYSKIISCCIVARDLSKNTMKLDVIF
                     FEDKNKRSAVLGLRRDKSGVFKSVTLHFTSAKKYAKVRKTDVKEMKWL"
     gene            2122..3999
                     /gene="pspA"
                     /locus_tag="VXE25_001435"
     CDS             2122..3999
                     /gene="pspA"
                     /locus_tag="VXE25_001435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001035354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal surface protein A"
                     /protein_id="HEV0771885.1"
                     /translation="MNKKKMILTSLASVAILGAGFVTSQPTFVRAEEAPVSSQSKAEK
                     DYDAAVKKSEAAKKHYEEVKKKAEDAQKKYDEGQKKTVEKAKREKEASEKIAEATKEV
                     QQAYLAYQQASNESQRKEADKKIKEATQRKDEAEAAFATIRTTIVVPEPSELAETKKK
                     AEEAKAEEKVAKRKYDYATLKVALAKKEVEAKELEIEKLQYEISTLEQEVATAQHQVD
                     NLKKLLAGADPDDGTEVIEAKLNKGEAELNAKQAELAKKQTELEKLLDSLDPEGKTQD
                     ELDKEAEEAELDKKADELQNKVADLEKEISNLEILLGGADSEDDTAALQNKLATKKAE
                     LEKTQKELDAALNELGPDGDEEETPAPAPQPEQPAPAPKPEQPTPAPKPEQPTPAPKP
                     EQPAPAPKPEQPAPAPKPEQPAPAPKPEQPTPAPKTGWKQENGMWYFYNTDGSMATGW
                     LQYNGSWYYLNANGAMATGWAKVNGSWYYLNANGAMATGWLQYNDSWYYLNASGAMAT
                     GWLQYNGSWYYLNANGSMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYLNANGSM
                     ATGWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGLGALAVNTTVDGYKVNANGEW
                     V"
     gene            4400..5521
                     /gene="mnmA"
                     /locus_tag="VXE25_001436"
     CDS             4400..5521
                     /gene="mnmA"
                     /locus_tag="VXE25_001436"
                     /EC_number="2.8.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 2-thiouridine(34) synthase MnmA"
                     /protein_id="HEV0771886.1"
                     /translation="MSDNSKTRVVVGMSGGVDSSVTALLLKEQGYDVIGIFMKNWDDT
                     DENGVCTATEDYKDVVAVADQIGIPYYSVNFEKEYWDRVFEYFLAEYRAGRTPNPDVM
                     CNKEIKFKAFLDYAMTLGADYVATGHYARVARDEDGTVHMLRGVDNGKDQTYFLSQLS
                     QEQLQKTMFPLGHLEKPEVRRLAEEAGLSTAKKKDSTGICFIGEKNFKNFLSNYLPAQ
                     PGRMMTVDGRDMGEHAGLMYYTIGQRGGLGIGGQHGGDNAPWFVVGKDLSKNILYVGQ
                     GFYHDSLMSTSLEASQVHFTREMPEEFTLECTAKFRYRQPDSKVTVHVKGDKAEVIFA
                     EPQRAITPGQAVVFYDGEECLGGGLIDNAYRDGQVCQYI"
     gene            5662..6117
                     /locus_tag="VXE25_001437"
     CDS             5662..6117
                     /locus_tag="VXE25_001437"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HEV0771887.1"
                     /translation="MTQQDFRTKVDNTVFGVRATALIVQNHKLLVTKDKGKYYTIGGA
                     IQVNESTEDAVVREVKEELGVKAQAGQLAFVVENRFEQDGVSYHNIEFHYLVDLLEDA
                     PLTMQEDEKRQPCEWIDLDKLEDIQLVPAFLKTALPDWKGQLRHIHLEK"
     gene            6127..8040
                     /gene="mnmG"
                     /locus_tag="VXE25_001438"
     CDS             6127..8040
                     /gene="mnmG"
                     /locus_tag="VXE25_001438"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000221902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis enzyme MnmG"
                     /protein_id="HEV0771888.1"
                     /translation="MTYHFTEEYDIIVIGAGHAGVEASLAASRMGCKVLLATINIEML
                     AFMPCNPSIGGSAKGIVVREVDALGGEMAKTIDKTYIQMKMLNTGKGPAVRALRAQAD
                     KELYSKEMRKTVENQENLTLRQTMIDEILVEDGKVVGVRTATHQEYAAKAVIVTTGTA
                     LRGEIIIGDLKYSSGPNHSLASINLADNLKELGLEIGRFKTGTPPRVKASSINYDVTE
                     IQPGDEAPNHFSYTSRDEDYVKDQVPCWLTYTNGTSHEIIQNNLHRAPMFTGVVKGVG
                     PRYCPSIEDKIVRFADKERHQLFLEPEGRNTEEVYVQGLSTSLPEDVQRDLVHSIKGL
                     ENAEMMRTGYAIEYDMVLPHQLRATLETKKISGLFTAGQTNGTSGYEEAAGQGIIAGI
                     NAALKIQGKPELILKRSDGYIGVMIDDLVTKGTIEPYRLLTSRAEYRLILRHDNADMR
                     LTEMGREIGLVDDERWARFEIKKNQFDNEMKRLDSIKLKPVKETNAKVEEMGFKPLTD
                     AVTAKEFLRRPEVSYQDVVAFIGPAAEDLDDKIIELIETEIKYEGYISKAMDQVAKMK
                     RMEEKRIPANIDWDDIDSIATEARQKFKLINPETIGQASRISGVNPADISILMVYLEG
                     KNRSISKTLQKSK"
     gene            8244..8321
                     /locus_tag="VXE25_001439"
                     /pseudo
     CDS             8244..8321
                     /locus_tag="VXE25_001439"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002674100.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            complement(8419..10098)
                     /locus_tag="VXE25_001440"
     CDS             complement(8419..10098)
                     /locus_tag="VXE25_001440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009729634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease J"
                     /protein_id="HEV0771889.1"
                     /translation="MAYTLKPEEVGVFAIGGLGEIGKNTYGIEYQGEIIIVDAGIKFP
                     EDDLLGIDYVIPDYSYIVDNIDRVKAVLITHGHEDHIGGIPFLLKQANVPIYAGPLAL
                     ALIRGKLEEHGLLRNAKLYEINHNTELTFKNLKATFFRTTHSIPEPLGIVIHTPQGKI
                     VCTGDFKFDFTPVGEPADLHRMAALGEEGVLCLLSDSTNAEVPTFTNSEKVVGQSIMK
                     IIQGIEGRIIFASFASNIFRLQQATEAAVKTGRKIAVFGRSMEKAIVNGIDLGYIKAP
                     KGTFIEPNEIKDYPAGEVLILCTGSQGEPMAALSRIANGTHRQVQLQPGDTVIFSSSP
                     IPGNTTSVNKLINIISEAGVEVIHGKVNNIHTSGHGGQQEQKLMLCLIKPKYFMPVHG
                     EYRMQKVHAGLAVDTGVEKDNIFIMSNGDVLALTADSARIAGHFNAQDIYVDGNRIGE
                     IGAAVLKDRRDLSEDGVVLAVATVDFKSQMILSGPDILSRGFVYMRESGDLIRQSQRI
                     LFNAIRIALKNKDASVQSVNGAIVNAIRPFLYENTEREPIIIPMILTPDEE"
     gene            complement(10100..10333)
                     /locus_tag="VXE25_001441"
     CDS             complement(10100..10333)
                     /locus_tag="VXE25_001441"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000639444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-dependent RNA polymerase auxiliary subunit
                     epsilon family protein"
                     /protein_id="HEV0771890.1"
                     /translation="MIYKVFYQETKERSPRRETTRALYLDIDASSELEGRITARQLVE
                     ENRPEYNIEYIELLSDKLLDYEKETGAFEITEF"
     gene            10715..10936
                     /locus_tag="VXE25_001442"
     CDS             10715..10936
                     /locus_tag="VXE25_001442"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000184674.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771891.1"
                     /translation="MTNQVLEENYLCDSLLAFSPPRDLCRLVCILLWIKCLDALLMLG
                     FFVWGCRDSRFTTRKFHPIYQDEVVFAFF"
     gene            complement(11149..11301)
                     /gene="cibB"
                     /locus_tag="VXE25_001443"
     CDS             complement(11149..11301)
                     /gene="cibB"
                     /locus_tag="VXE25_001443"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000977347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fratricide two-peptide bacteriocin subunit CibB"
                     /protein_id="HEV0771892.1"
                     /translation="MMKDLNNCREISNKELQEIKGGFGVGVGIALFMAGYTIGKDLRK
                     KFGKSC"
     gene            complement(11303..11488)
                     /gene="cibA"
                     /locus_tag="VXE25_001444"
     CDS             complement(11303..11488)
                     /gene="cibA"
                     /locus_tag="VXE25_001444"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000180803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fratricide two-peptide bacteriocin subunit CibA"
                     /protein_id="HEV0771893.1"
                     /translation="MTNFDILDNQFLSLSENELSDIDGGLAPLVIFGVAVSWKAIAGG
                     TALIGSGLAAGYFLGGD"
     gene            11666..12349
                     /gene="tsaB"
                     /locus_tag="VXE25_001445"
     CDS             11666..12349
                     /gene="tsaB"
                     /locus_tag="VXE25_001445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000865689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     dimerization subunit type 1 TsaB"
                     /protein_id="HEV0771894.1"
                     /translation="MKVLAFDTSSKALSLAILEDKQVLAETTINIKKNHSITLMPAID
                     FLMASLDWTPKNLDRIVVAEGPGSYTGLRIAVATAKTLAHTLNIELVGMSSLLALVPY
                     QQEGLFVSLMDARRNNVYVGFYENAKPVMPEAHLPFERVIELIKGASQVTFVGEVGPF
                     VEQIQEYLPRTNFKETLPNAANLALWAWDKEADSLHDFVPNYLKRVEAEENWLKNHTE
                     SGESYIKRL"
     gene            12346..12783
                     /gene="rimI"
                     /locus_tag="VXE25_001446"
     CDS             12346..12783
                     /gene="rimI"
                     /locus_tag="VXE25_001446"
                     /EC_number="2.3.1.266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000569806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal protein S18-alanine
                     N-acetyltransferase"
                     /protein_id="HEV0771895.1"
                     /translation="MIEIKRIQQQPDLAQAIYAVIAAVYLVSPWTLEQIQADLSQDQT
                     WYALAYDGAEVIGFLAVQENLFEAEVLQIAVKGAYQGQGIASALFAQLPTDKEIFLEV
                     RKSNQRAQAFYKKEKMAVIAERKAYYHDPVEDAIIMKREIDEG"
     gene            12773..13783
                     /gene="tsaD"
                     /locus_tag="VXE25_001447"
     CDS             12773..13783
                     /gene="tsaD"
                     /locus_tag="VXE25_001447"
                     /EC_number="2.3.1.234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002896630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     transferase subunit TsaD"
                     /protein_id="HEV0771896.1"
                     /translation="MKDRYILAFETSCDETSVAVLKNDDELLSNVIASQIESHKRFGG
                     VVPEVASRHHVEVITACIEEALAEAGITEEDVTAVAVTYGPGLVGALLVGLSAAKAFA
                     WAHGLPLIPVNHMAGHLMAAQSVEPLEFPLLALLVSGGHTELVYVSEAGDYKIVGETR
                     DDAVGEAYDKVGRVMGLTYPAGREIDELAHQGQDIYDFPRAMIKEDNLEFSFSGLKSA
                     FINLYHNAEQKGESLSTEDLCASFQAAVMDILMAKTKKALEKYPVKTLVVAGGVAANK
                     GLRERLAAEITDVKVIIPPLRLCGDNAGMIAYASVSEWNKENFAGWDLNAKPSLAFDT
                     ME"
     gene            complement(13823..15129)
                     /locus_tag="VXE25_001448"
                     /pseudo
     CDS             complement(13823..15129)
                     /locus_tag="VXE25_001448"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011680908.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
     gene            complement(15405..15756)
                     /locus_tag="VXE25_001449"
                     /pseudo
     CDS             complement(15405..15756)
                     /locus_tag="VXE25_001449"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(15863..16156)
                     /locus_tag="VXE25_001450"
                     /pseudo
     CDS             complement(15863..16156)
                     /locus_tag="VXE25_001450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
     gene            16399..17605
                     /locus_tag="VXE25_001451"
                     /pseudo
     CDS             16399..17605
                     /locus_tag="VXE25_001451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001200043.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
     gene            17598..18551
                     /locus_tag="VXE25_001452"
     CDS             17598..18551
                     /locus_tag="VXE25_001452"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HEV0771897.1"
                     /translation="MDRNIDQELVSIIIPTHNRYESLIRAVKSCLHQSYKNIEVIIID
                     DNYSNVNLRNKIIHQFGYTNHRIKLILSNEDLGATNARNIGIKNSRGKYISFLDDDDE
                     YMPDRILKLMACFKKSRMKNLALVYSYGIIIYPNGTREEEKTDFVGNPLFVQMVHNIA
                     GTSFWLCKKEVLELINGFEKIDSHQDGVVLLKLLAQGYQIDIVREFLVNYYAHSKENG
                     ITGVTQKTINADEEYYNYCRKYFNLLSFNERILVTKKYYSLNIKRLLLIGDKCKALKV
                     IKKAREEKIFNEFPFLEYMLLYHFGFFYCIYDNYVQLKFRK"
     gene            18561..20177
                     /locus_tag="VXE25_001453"
     CDS             18561..20177
                     /locus_tag="VXE25_001453"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288036.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0771898.1"
                     /translation="MYTIIKSNIKKFSLLTIFIVAGQLLLIYAATINALVLNELIAMN
                     LERFLKLSIYQMIVWCGIIFLDWVVKNYQVEVIQEFNLEIRNRVATDISNSTYQEFHS
                     KSSGTYLSWLNNDVQTLNDQAFKQLFLVIKGISGTIFAVVTLNHYHWSLTVATLFSLM
                     IMLLVPKIFASKMREVSLNLTNQNEAFLKSSETILNGFDVLASLNLLYVLPKKIKEAG
                     ILLKMVIQRKTTVETLAGAISFFLNIFFQISLVFLTGYLAIKGIVKIGTIEAIGALTG
                     VIFTALGELGGQLSSIIGTKPIFLKLYSINPIESNKMNDIEPNEVNRDFPLYEAKNIC
                     YKYGDKEILKNLNFCFQRNEKYLILGESGSGKSTLLKLLNGFLRDYSGELRFCGDDIK
                     KTSYLNMVSNVLYVDQKAYLFEGTIRDNILLEENYTDEEILQSLEQVGLSVKDFPNNI
                     LDYYVGDDGRLLSGGQKQKITLARGLIRNKRIVLIDEGTSAIDRRTSLAIERKILDRE
                     DLTVIIVTHAPHPELKQYFTKIYQFPKDFI"
BASE COUNT         6449 a         3541 c         4478 g         6063 t
ORIGIN      
        1 agattatttg acacaagtac tttaatgaag aggagaatat tttttctttt cgcattggat
       61 gttatagctt acttattttt aggatatctt ttagtgattc aaaaagcagg ctatttgttt
      121 tcggttttac ttcttttttc taatttttca gttccattta tcaaagcaaa ggaatacgaa
      181 ttatttaaaa atagcaagta atagaaacat aggttaaatc ttagaacggc ttaaaatcag
      241 atatgataaa gggaaatagt cttatctagg taactaagtg ctacaaacac agtcgaggat
      301 cacttgttag gattacattt taatcatgct taataagaat ggagaattcc tatggggatt
      361 gtattactct gaagtttcga ataccttagt tctcgtgatt ttgagctgtt ctagctttag
      421 aatccttcag aatgtaaaat tttaagcagt caaagactta gaatagcctg gaaacattta
      481 ttttatagca attctaggct tagaattgct catatatatg tatttgagct gctcgatagt
      541 taggacagct ctattctgag aaatctgagc tatcaatgct tcagaatagt atttcgcaaa
      601 tggtttttat tgaagaggtg attgttttat gatagtctaa aataaaactg atttaatgga
      661 gtaaatggag aatcgtcaca tgaaacattt ttttgcagga attggtgaga taaaacttgt
      721 tggctactta ttgtatatat gtgtaggact agcccctctt tttcatatat atgtcatagg
      781 ttcggaactg agttttgtga aaatagtgtt atctattttg ggagttatat ttgtaagtat
      841 gttaactatt gctcgaattt atcggacttt tctataaaga atagtttgga cttgaactgt
      901 atctaaaaac agaggttggt cgattatcag cctctttctt gtcgttgaaa agagtgagat
      961 atattgactt ttgaaaaaaa tgtcataatt gagttgggat aaacctaaaa gtaatatagt
     1021 agattgaatc tggaatagtc cgttatgact gttaaaatat ttctagaaat taatttgact
     1081 ttcctaatcg atttgttcac atcttgtttc aatctactat actttctcgt taaaccgttc
     1141 ggcaattcat ggtgacatgg acacatagta gtaagcacac tatgtggctt ggcagagcta
     1201 aaaactgttc ccttgcgata agcctaataa gcacaacata gggagttaga gaagccgact
     1261 ctaatcaacc actttgggca gtagtgagaa ctgccccgtg cttttttatt ttgagaaaat
     1321 atggagtttg tcgttgaaat tacttgattg tattttggac tatcaagaaa gattcaatgg
     1381 aaaaacatgt caagtatcaa cgaattataa gtatttagag attttcaaag tgaatttttg
     1441 cttgactgat ttacatcatt tatttgactt atacaaaatc acacgagatt atgctagtca
     1501 aacaaaacct gctattcaag ctggtgtttt tattttagaa gattttagaa atatcctatg
     1561 tacaatgatg taatcgaaag gatatcttta tatgagttta tcggtgatat tttctattct
     1621 aaaataataa gttgttgcat cgtagctagg gatttatcta aaaatactat gaaattggac
     1681 gtcatatttt ttgaggataa aaataaaaga tccgcagttt taggtttacg aagagacaaa
     1741 agcggagtat ttaaatcagt tactctacat tttacaagcg ctaagaaata tgctaaagtt
     1801 cgtaaaacag atgtgaaaga aatgaaatgg ctataaagat tgtccgcagg cttaagcttg
     1861 cgttttttgt tgtttaacga aattaaaaaa taagctctct cattggaaat gtttttatag
     1921 gaatgaagga agatgatgct atgtttaaaa agagaatcga aaagggcaaa agtagtgtct
     1981 ttatcttttt ggagtagaag cttatgatat agaaatttgt aataaaaatg taatataaaa
     2041 catttgacaa atatttacgg ggggagtata cttaatataa gtatagtcta aaaatgacta
     2101 tcagaaaaga ggtaaattta gatgaataag aaaaaaatga ttttaacaag tctagccagc
     2161 gtcgctatct taggggctgg ttttgttacg tctcagccta cttttgtaag agcagaagaa
     2221 gctcccgtat ctagtcagtc taaagctgag aaagactatg atgcagcagt gaaaaaatct
     2281 gaagctgcta agaaacatta tgaagaagtt aaaaagaaag cagaagacgc tcagaagaaa
     2341 tatgacgagg gtcagaagaa aacggtagaa aaagcaaagc gagaaaaaga agcttctgaa
     2401 aagatagctg aggcaacaaa agaagttcaa caagcgtacc tagcttatca acaagctagc
     2461 aacgaaagtc agagaaaaga ggcagataag aagataaaag aagctacgca acgcaaagat
     2521 gaggcggaag ctgcatttgc tactattcga acaacaattg tagttcctga accaagtgag
     2581 ttagctgaga ctaagaaaaa agcagaagaa gctaaagcag aagaaaaagt agctaagaga
     2641 aaatatgatt atgcaactct aaaggtagca ctagcgaaga aagaagtaga ggctaaggaa
     2701 cttgaaattg aaaaacttca atatgaaatt tctactttgg aacaagaagt tgctactgct
     2761 caacatcaag tagataattt gaaaaaactt cttgctggtg cggatcctga tgatggcaca
     2821 gaagttatag aagctaaatt aaacaaagga gaagctgagc taaacgctaa acaagctgag
     2881 ttagcaaaaa aacaaacaga acttgaaaaa cttcttgaca gccttgatcc tgaaggtaag
     2941 actcaggatg aattagataa agaagcagaa gaagctgagt tggataaaaa agctgatgaa
     3001 cttcaaaata aagttgctga tttagaaaaa gaaattagta accttgaaat attacttgga
     3061 ggggctgatt ctgaagatga tactgctgct cttcaaaata aattagctac taaaaaagct
     3121 gaattggaaa aaactcaaaa agaattagat gcagctctta atgagttagg ccctgatgga
     3181 gatgaagaag aaactccagc gccggctcct caaccagagc aaccagctcc tgcaccaaaa
     3241 ccagagcaac caactcctgc accaaaacca gagcaaccaa ctcctgcacc aaaaccagag
     3301 caaccagctc ctgcaccaaa accagagcaa ccagctcctg caccaaaacc agagcaacca
     3361 gctcctgcac caaaaccaga gcaaccaact cctgcaccaa aaacaggctg gaaacaagaa
     3421 aacggtatgt ggtacttcta caatactgat ggttcaatgg ctacaggttg gctccaatac
     3481 aatggttcat ggtattacct aaacgctaac ggcgctatgg caacaggttg ggctaaagtc
     3541 aacggttcat ggtactacct aaacgctaat ggtgctatgg ctacaggatg gctccaatac
     3601 aacgattcat ggtattacct aaacgctagc ggcgctatgg caacaggttg gctccaatac
     3661 aacggttcat ggtactacct caacgctaac ggttcaatgg caacaggttg gctccaatac
     3721 aacggttcat ggtactacct caacgctaac ggcgctatgg caacaggttg ggctaaagtc
     3781 aacggttcat ggtactacct caacgctaac ggttcaatgg caacaggttg ggtgaaagat
     3841 ggagatacct ggtactatct tgaagcatca ggtgctatga aagcaagcca atggttcaaa
     3901 gtatcagata aatggtacta tgtcaatggt ttaggtgccc ttgcagtcaa cacaactgta
     3961 gatggctata aagtcaatgc caatggtgaa tgggtttaag ccgattaaat taaatcatgt
     4021 taagaacatt tgacatttta attttgaaac aaagataagg ttcgattgaa taaatttatg
     4081 ttcgtattct ttaggtacct atcttatgat ttcaggaaat gtcattaaaa aaacgactcc
     4141 ttttctctaa cttgaaaaat agattagaga aaatgggttg ttttatttat tatagttatt
     4201 tgaatgaaga taagaagaag gtatactcac atcattcaca taatctgtat attgactata
     4261 agttttaaaa aacaattttt aagctcttcc ttgtcttctc taaccaagcg tgttataatg
     4321 aatactgctc aagcgacctt caatcgtgaa gcacacacga ccttcaatcg tgaataaacg
     4381 aatagatggg agacttacca tgagtgataa ctctaaaaca cgtgttgtcg tggggatgag
     4441 tggtggtgtt gattcgtcgg tgacggctct tttgcttaag gagcagggct acgatgtgat
     4501 cggtatcttc atgaagaact gggatgacac agatgaaaac ggcgtttgta cggcgaccga
     4561 agattacaag gatgtggttg cggtggcaga ccagattggc attccctact actctgtcaa
     4621 ttttgaaaaa gagtactggg accgcgtttt tgagtatttc ctagcggaat accgtgcagg
     4681 gcgcacgcca aatccggacg ttatgtgcaa caaggaaatc aagttcaagg cctttttgga
     4741 ctatgccatg accttggggg cagactatgt agcgactggg cattatgctc gagtggcgcg
     4801 tgatgaggac ggcactgttc acatgcttcg tggcgtggac aatggcaagg accagaccta
     4861 tttcctcagc caactttcgc aagaacaact ccaaaaaacc atgttccctc tgggacattt
     4921 ggaaaagcct gaagtacgca gactagcaga agaagcaggc ctttcgactg ctaagaagaa
     4981 agactcgaca gggatttgct ttatcggaga aaagaacttt aaaaactttc tcagcaacta
     5041 cctgccagct cagcctggtc gtatgatgac tgtggatggt cgcgatatgg gcgagcatgc
     5101 tggtctgatg tactatacaa tcggtcagcg tggcggactc ggtatcggtg ggcaacacgg
     5161 cggtgacaat gccccttggt tcgttgttgg aaaagatcta agcaagaata ttctctatgt
     5221 aggacaagga ttctaccatg attcgctcat gtcaactagc ctagaagcca gtcaagtcca
     5281 ctttactcgt gaaatgccag aagagtttac gctagaatgt acggctaaat tccgttaccg
     5341 tcagcctgac tctaaggtga ccgtccatgt caaaggagac aaggcagaag ttatctttgc
     5401 ggaaccacaa cgcgcgatta caccaggaca ggcagttgtc ttttacgatg gcgaagagtg
     5461 tctaggtggc ggtttgattg acaatgctta ccgcgatgga caagtttgtc agtacattta
     5521 gattgacaaa ttttctcaat ttgctacaat aataacagca atagaaatga tggtcaaagc
     5581 tcatggatgt tgcaggcttt tttgtcctgc acttctttgt agttttgact gtttttgtgt
     5641 cgtttaaggg aaaggacaag aatgactcaa caagactttc ggacaaaagt agacaatacg
     5701 gtttttggtg ttcgggctac agccttgatt gtccaaaatc acaagcttct agttaccaaa
     5761 gacaagggca agtattacac tattggaggt gcgattcaag tcaatgaaag cacggaagac
     5821 gcggtagtcc gtgaagtgaa ggaagaactg ggtgtcaaag ctcaagctgg gcagctagct
     5881 tttgtggttg aaaatcgttt tgaacaggac ggtgtttcct atcacaatat cgaatttcat
     5941 tatctggtag acttactgga ggatgcccca ttgaccatgc aggaagatga gaaaaggcag
     6001 ccctgtgagt ggattgactt ggataagctt gaggatatcc agctagttcc agccttttta
     6061 aaaacggccc taccagattg gaaaggccaa ctaagacaca tccatcttga gaaataggag
     6121 agaaatatga catatcattt tactgaagaa tacgatatta ttgtaattgg tgcgggacac
     6181 gctggggttg aggcttcctt ggccgctagc cgtatgggct gtaaggtcct gcttgcgacc
     6241 atcaatattg aaatgctggc tttcatgcct tgtaatccct ctatcggtgg ttctgctaag
     6301 gggattgtcg tacgtgaagt cgatgccctc ggtggcgaga tggccaagac cattgacaag
     6361 acttacatcc agatgaagat gctcaacaca gggaaggggc cagccgttcg tgcccttcgt
     6421 gcgcaggctg acaaggaact ttactctaag gaaatgcgca agacagttga aaaccaagaa
     6481 aatctgaccc ttcgtcaaac catgattgat gagattttgg tggaagatgg caaggttgtc
     6541 ggtgtgcgta cagccaccca tcaagaatat gctgctaagg ctgttattgt gacgacaggg
     6601 actgctctcc gtggggaaat tatcatcgga gacctcaagt actcatcagg tcctaaccac
     6661 agcttggctt ctattaacct agctgataat ctcaaggaac tgggcctcga aatcggtcgt
     6721 ttcaagacag gaacccctcc acgtgtcaag gcttcttcta tcaactacga cgtgacagaa
     6781 atccaaccag gagatgaagc gcctaatcac ttctcataca cttcacgtga tgaggattat
     6841 gtcaaggacc aagtgccatg ctggttgacc tacaccaatg gtaccagtca tgagattatc
     6901 caaaacaacc tccaccgtgc gcctatgttt acaggtgtgg tcaagggagt ggggcctcgt
     6961 tactgtccgt cgattgaaga caagattgtg cgctttgcgg acaaggaacg tcaccaactc
     7021 ttccttgaac cagaagggcg caatactgag gaagtctatg tgcaaggact ttcaaccagt
     7081 ctgcctgagg atgtccagcg tgacttggtt cattccatca aaggtttgga aaatgcagag
     7141 atgatgcgga caggttatgc tattgagtat gatatggtct tgcctcatca gttgcgtgcg
     7201 actctggaaa ccaagaaaat ctcaggtctc ttcactgctg gtcagacaaa tggaacgtca
     7261 ggttacgaag aggcagcagg ccaagggatt atcgcgggta tcaatgcggc tctgaaaatc
     7321 caaggtaagc ctgagttgat tttgaagcga agtgacggtt atatcggggt gatgatcgac
     7381 gacttggtga ccaagggaac cattgaacct taccgtctct tgaccagtcg tgctgaatat
     7441 cgtctcattc ttcgccatga caatgctgat atgcgcttga ctgagatggg acgcgagatt
     7501 ggccttgtgg atgatgaacg ctgggctcgt tttgaaatca agaaaaatca atttgataat
     7561 gagatgaaac gcctagacag tatcaaactc aagccagtca aggaaaccaa tgctaaggtt
     7621 gaggaaatgg gcttcaagcc cttgacagat gcggtgacag ccaaggaatt ccttcgccgt
     7681 ccagaagttt cttaccaaga tgtggtggcc ttcatcggac cagctgcaga agacttggat
     7741 gacaagatta tcgaattgat tgaaacagaa atcaagtacg aaggctatat ttcaaaagcc
     7801 atggatcagg ttgccaagat gaaacgtatg gaagaaaaac gcattccagc caatattgac
     7861 tgggatgaca ttgactctat cgcaacagaa gctcgtcaga agttcaaact catcaatcca
     7921 gaaaccatcg gccaagccag ccgtatttcg ggagtaaacc cagcagatat ttctattttg
     7981 atggtgtatc tggaaggtaa aaatcgtagt atttctaaaa ctcttcaaaa atcaaaatga
     8041 tacgtcgttg gcttcttacg aatgagttca aagcttggct ttgattcatc tccagcctcc
     8101 catagtttcc cgaactatgg gagctaactc aagttatgca ttttcctagc cttctggtct
     8161 gattttcatt gagttttaat ctcaaaagaa agcatagaga aaaacagctc cgaagacggg
     8221 gctgttttgt tgacttgtac tcaatgaaaa tcaaagagca aactaggaag ctagccgtag
     8281 gttgctcaaa gcactgcttt gaggttgtag atagaactga cgaagtcagc tcaaaacaca
     8341 gttttgaggt tgtggataga attgacgaag tcagtaacat atatacggca aggcgaagct
     8401 gacgtggttt gaagagtatt attcttcatc tggtgtgagg atcatcggga tgatgatcgg
     8461 ttcacgttcg gtattttcat agaggaaggg gcgaatagcg ttgacaatgg caccattgac
     8521 agattgcacg ctagcatcct tatttttcag tgcgatacga atggcattga agaggatacg
     8581 ctggctttgg cgaatcaagt cgccagactc tctcatgtag acaaagcctc ggctgaggat
     8641 gtctggacca gatagaatca tctgcgattt gaagtcaaca gttgcgactg ccagaacgac
     8701 accgtcttca gatagatcgc gacgatcttt gaggacagct gcgccaattt caccgatacg
     8761 atttccatcg acatagatat cttgggcgtt gaaatgacct gcgatacgag ctgagtcagc
     8821 agtaagggca agcacatcgc cattgctcat gataaagata ttgtccttct caacaccagt
     8881 atccactgct agtccagcgt ggactttttg catgcggtat tcaccgtgga caggcatgaa
     8941 gtattttggc ttaatcaagc agagcatgag tttttgctct tgctgaccac cgtgtccaga
     9001 tgtatggata ttgttcactt taccgtggat aacttcgaca ccagcttcag aaatgatgtt
     9061 aatcagcttg ttgacgctag tagtgtttcc agggatggga ctagaagaga agataacggt
     9121 atcacctggt tgtaattgta cttgacggtg ggttccgttg gcgatacgag agagggctgc
     9181 cataggctca ccctgactac ctgtacagag gataagaact tctcctgcag gataatcttt
     9241 gatttcattt ggctcgataa aggttccctt aggagctttg atgtagccaa gatcgattcc
     9301 gttgacaatg gccttttcca tagaacgacc aaagaccgca atcttgcgtc cagtcttaac
     9361 agcagcttct gttgcctgct ggagacggaa gatatttgag gcaaaggatg caaagatgat
     9421 acgtccttca ataccttgga taatcttcat aatggactga ccaacgactt tttcagagtt
     9481 ggtaaaggtt ggtacttccg catttgtcga gtcagacagg agacagagca cgccttcttc
     9541 accaagcgca gccatacgat gcaagtccgc aggttctcca actggagtaa agtcgaactt
     9601 aaagtcaccc gtacagacga ttttcccttg aggagtatga atgacaatcc ccaaaggctc
     9661 tggaatagag tgagtcgttc taaagaaagt tgccttgaga tttttaaagg tcaactcggt
     9721 gttgtggttg atttcgtaaa gtttggcgtt gcgcaagagg ccgtgttctt cgagtttccc
     9781 acggatcaaa gccaaggcaa gcggtccagc gtagataggg acatttgctt gcttgagtag
     9841 gaacggaatc ccaccaatgt ggtcctcgtg tccgtgtgtg attaaaacag ccttgacgcg
     9901 gtcgatattg tccacgatgt aagagtagtc aggaatgaca tagtcgatac caagcaagtc
     9961 atcttctggg aatttaatcc cagcatcgac gatgataatc tcgccttggt attcaattcc
    10021 gtaagtgttt ttcccgattt ctcctagacc accgatggca aaaacgccga cttcttcagg
    10081 tttaagagtg taggccatat tagaactccg taatttcgaa ggcgccagtt tctttttcgt
    10141 aatcgagcaa tttgtcagac aagagttcga tatattcgat attgtactct gggcgatttt
    10201 cttcgacaag ttggcgagca gtgatacggc cctcaagttc tgagctggca tcgatgtcta
    10261 ggtaaagcgc gcgtgttgtt tcacggcgtg ggctacgttc ttttgtttct tgataaaaaa
    10321 ctttgtaaat catatagttc ctttctattt acaggtcagc ttattccaaa cttttagcag
    10381 atatttgctt gatttcattc cattttgtgt ctagattgac cttgattcgt tacaattatt
    10441 tcaattatac cacaaaatga aaaattagta aaagacggaa acgagaaagt taggggacga
    10501 tttcttcggt aagcgtttgc gaaaataaag aaaatgtatt atgttgataa cggaagtgaa
    10561 atttattgct tgtcataatt ccatatagat tttaagtcaa ggaggttgcc ctatgtataa
    10621 cttatttgct tttgctatcg gagttcgttt gctagctttt atcgtttttg ttttgcgttt
    10681 atggaggaaa tcttctattt gccaaactgg aacgatgaca aaccaagttc ttgaggaaaa
    10741 ttacctttgt gactctctac tcgctttttc tcctcctcgt gacctatgtc gtttggtttg
    10801 tattttactt tggattaaat gcttagatgc cctgcttatg ctggggtttt ttgtttgggg
    10861 atgtagagat agtagattta cgacacgaaa attccacccc atctatcaag atgaggtggt
    10921 ctttgcattt ttctaaaatg atatgacaat ggaattttca aagcttatta tttttatggg
    10981 agtcattgtt ctgctcaaaa atagagttga agcataaaaa taaaacaata caaacagata
    11041 aatcgaatgg taaagggatg gtagtaatgt tcaaatcatt gagaatgctg agcaaactgt
    11101 aagagatgaa gacaataaaa tttatccttc taaaaatgtg tttcttatct agcatgactt
    11161 accaaacttt ttacgaaggt cttttccaat ggtataacct gccataaata aagcgatacc
    11221 aacacctaca ccaaagccac ccttgatttc ttgcaattcc ttattagaaa tttcacgaca
    11281 gttgttcaaa tctttcatca tattaatctc ctcctaaaaa ataaccagct gccaaaccag
    11341 aacctataag tgctgttcca cctgcaatag ctttccaaga tactgctact ccaaagataa
    11401 ccaagggagc gagaccgcca tcaatatctg ataattcatt ttcagataag gataaaaatt
    11461 gattgtcaag aatgtcaaaa tttgtcattg aactttcctc cttttttctt gttcactttt
    11521 atattcggaa aagaaaagga aaagtgagca tttttttaaa ttatttttag ttaagtgagg
    11581 gcactcttgt ctgggggcaa agaaaattcc catgtgccag cttttgtagt ataatagtaa
    11641 gcagacaaaa agataggaat gtgttatgaa agtattagct tttgatacgt ccagcaaggc
    11701 tctttctctc gctattttag aggacaagca ggttcttgcc gagacgacga ttaatattaa
    11761 gaaaaatcac agtattactc ttatgcctgc catagatttt ttgatggcaa gtttggattg
    11821 gacacccaag aatttggacc gaatcgtggt agctgaaggg ccgggtagct acacaggctt
    11881 gcgaattgcg gtagccactg ccaagacttt ggctcatact ctgaacatcg agttagttgg
    11941 tatgtctagc ctcttggctc tggtacccta ccaacaagaa ggcttgttcg tctctttgat
    12001 ggatgcgcgt cgcaacaatg tttatgtagg attttatgaa aatgctaaac ccgtcatgcc
    12061 agaagctcac ttaccctttg agcgagtgat tgagttaatc aagggtgcta gtcaggttac
    12121 ctttgtcgga gaagttggcc cctttgttga gcagattcaa gaatacttgc caaggactaa
    12181 tttcaaagaa accttgccaa atgcagctaa tctagctcta tgggcctggg acaaggaagc
    12241 agactccttg catgattttg tgccgaatta cctcaaacga gtcgaggctg aggaaaactg
    12301 gctcaagaac cataccgagt ctggtgagtc ctacattaaa cgcctatgat agaaatcaag
    12361 cgaattcaac aacagcctga cctagctcaa gccatctacg ctgttatagc agctgtttac
    12421 ctagtcagtc cttggactct ggagcaaatc caagcagatc tgtcccaaga ccagacttgg
    12481 tatgcattgg cttatgatgg ggcagaagtg attggatttc tagctgtgca ggagaatctt
    12541 tttgaagcag aagtcctgca aatcgctgtc aaaggagcct atcagggtca gggaattgcg
    12601 tcagccttgt ttgctcaatt gccgacagat aaggagattt tcctcgaagt cagaaagtca
    12661 aatcaacgag cgcaagcatt ttacaagaaa gaaaaaatgg cggtcatcgc tgagcgaaag
    12721 gcctactacc atgacccagt cgaggacgcc attatcatga agagagaaat agatgaagga
    12781 tagatatatt ttagcatttg agacatcctg tgatgagacc agtgtcgccg tcttgaaaaa
    12841 cgacgatgag ctcttgtcca atgtcattgc tagtcaaatt gagagtcaca aacgttttgg
    12901 tggcgtagtg cccgaagtag ccagtcgtca ccatgtcgag gtcattacag cctgtatcga
    12961 ggaggcattg gcagaagcag ggattaccga agaggacgtg acagctgttg cggttaccta
    13021 cggaccaggc ttggtcggag ccttgctagt tggtttgtca gctgccaagg cctttgcttg
    13081 ggctcacgga cttccactga ttcctgttaa tcacatggct gggcacctca tggcagctca
    13141 gagtgtggag cctttggagt ttcccttgct agccctcttg gtcagcggcg gacacacaga
    13201 gttggtttat gtttcggagg caggagatta taagattgtt ggggaaaccc gtgatgatgc
    13261 ggttggtgag gcttatgata aggtcggccg tgtcatgggc ttgacctatc ctgcaggtcg
    13321 tgagattgac gagctggctc atcaggggca ggatatttat gatttccccc gtgccatgat
    13381 taaggaagat aatctggagt tctccttctc aggtttgaaa tctgccttta tcaatcttta
    13441 tcacaatgcc gagcaaaagg gagaaagcct gtctacagaa gatttgtgtg cttccttcca
    13501 agcagcagtt atggacattc tcatggcaaa aaccaagaag gctttggaga aatatcctgt
    13561 taaaaccctg gttgtggcag gtggtgtggc agccaataaa ggtctcagag aacgcctagc
    13621 agccgaaatc acagatgtca aggttatcat cccccctctg cgactctgcg gagacaatgc
    13681 aggtatgatt gcctatgcca gcgtcagcga gtggaacaaa gaaaacttcg caggctggga
    13741 cctcaatgcc aaaccaagtc ttgcctttga taccatggaa taaagagtgg ctctttgtca
    13801 agtgtagtgg gtaggcgaaa agctacaatc tggagagtac gaaattcgta ctctcttttt
    13861 tgatgttcaa agtcatcaaa atccgttttt taaaattgtt aaagttccgg aaaccaaagg
    13921 ctttgcgctt gataatctta atcaaattat tggtcgcttc aagtttagcg ttggaataag
    13981 gcagcttaag tgcgttgata atcttatctc tatcccttaa aaaagtccaa aagaccgttt
    14041 gaaaaagcgg atgaaccgtt ggcagttctt gctcaatcaa tccaaagaaa tggtcggcat
    14101 tcttctcttg aaaatgaaag agcaggagtt gatagagttc gtagtgaacc tgtaatccct
    14161 cagagtaaga cagcagctta tctcgtactt cccgatgggt taagtgcatt cgaaacgtgg
    14221 gctgatagaa tcgtttctga cagagcttga agctatactg gtgtagtaaa tcagtccagt
    14281 ggactgattt agcccgagcc tagaaacgaa aaagcgaggg ttccaaaagc gcttgagcgc
    14341 ccgatactcc aaggattttc ggtcaaattg gttcatgatt tggattcgta ctcggttcat
    14401 agctcggctc agatgttgga caatgtggaa gcggtcaaga acaatcttcg cctttggaaa
    14461 gagttgctta gcgagccgat aataagggct gtacatgtcc atggtgatga cctcgaccag
    14521 ctcccgaacc tctctctgat agcgttggaa atggtttcga atcaccgcat gagttcgccc
    14581 gtctaaaatt gcgaggatgg atttggactc aaaatcttgg gcaatgaagc tcattttgct
    14641 ctttttgaag ctatactcat cccaactcat aacttttggc aacttggtcc aatcggtttc
    14701 aaacttaaat tccctcagtt ttcggatgac ggtggaagtt gagaccgcca atctgtgggc
    14761 aatctcagtc atagactgct tttcaaggag gagctgagcg attttttgtc tcaccatgtt
    14821 ggaaatctgg caatttttct tgacaatgga tgtttgagaa acgaccacct taaggcaatt
    14881 cttgcactga aagcggcgct ttttgagatg cagtaccgtg ggtaaaccct gacagtcgag
    14941 aagcggaatt ttagaggctt tctggaagtc gtatttgatc atcttccctt gacaatgagg
    15001 acaaggagga gcgggggaat ccaactttgc ctgaacgact agatgggttt ggtatttcag
    15061 aacagacaag attttgatat ttttgtcttc caatccgagc aaatctgtgg tattcttaag
    15121 ttgttccata tgaccccttt ctaatgagtt ggttagacgc ttttcattat aggtcatatg
    15181 gggctttttt tctacaagaa acgaccctat aattcctggg gtgggattac ccactacaga
    15241 aattatagag ccaaaacatt ccaaagtatt gtctgactct ggaatgtttt ctgttcacag
    15301 ttgttttgta actgcctaat aagtaaccgc gctataacga ggtatctacc gagattgtca
    15361 attctccagt atactgttat aaaaaacaaa actggaggat ttttttatgt ccccccatcg
    15421 tcccatcgac tgttccgtag ctgcccaata acggagtata gtcggctgaa acaagaatag
    15481 gacaaaagta cctcaagaaa agcatcgtaa tttgacaata ttattctgag atgtttttga
    15541 tgtaagccca tattttctca atgggattat actcgggtga ataggtagga agtggtagca
    15601 gtctatgccc tgctccttac acatgttcat tctgtgaaac cttgcattgt ccataatgat
    15661 aagggatggt gtatctaaag taggtagtaa gaatttttgg aagcaagctt cgaaaaagtc
    15721 actcgtcatc gtatctttat aggtcatcgg agccatagta tattgaaaca aaaaagggca
    15781 ttagtacttc tataacagta tcgcaatctc tggtgtgcgt tgtctcgatc ttaattcaaa
    15841 taattatatc ttcttccaga gagactaact gcctgctcaa ggctcgatca tattcgagat
    15901 aaaaataggt ctcaacccct gtctcataaa tataaatagg agtcaggtag cttaagtgat
    15961 tcaattcttt aaggaaccga tttacttttt ctgggtcttg ttcgcagtag gtacggctct
    16021 tttttagact atatcccata gcctttagag cgtaatgaat agttgttgga ggacagttga
    16081 attcagcagc tatttcagtc aaataagcat cgggatgagt ttcaatatag atctttaatt
    16141 tatctctatc aactttttca attaatagtg gaagttttct taaagttagt gtgttgaaac
    16201 gtttttatac agtgctaaaa tttgaagtgt agtgcagatg tatttgtaat agtattatag
    16261 caattctttg gagaaggtcg agacaagaga aaataggtat ctttgagata taagcatgat
    16321 ttactataaa attattgagt tattcataaa aatttctcta tcaaatatca taatgcgtcg
    16381 tttaaggaga tggttacaat gcaatatagt tgtggaaaaa taaatattaa tatccctgat
    16441 ggatatggag acattaagga tatagtgttt tcggctcata ttatagttag gtataataat
    16501 ggacattgtg gaggtataga tccgcatata attggacttt gtaaaaagca gatcagaagg
    16561 atgtttctat atcctatttt gataatcgta tctagagatt caaaggttat tgatgattat
    16621 aaaaatttag atattgccta tgttgattgt actcaatgtt caaataattt tgaaactgcc
    16681 ttacacgtta aaaatatttt aaaattatta aaaatctaac ttatacactg tcatggctac
    16741 tcaactaatt attttttata tatgttaaaa aaacttgaca agaatggatt tggaaaggtt
    16801 aagacagtga taacatgcca tggatgggtt gaatataact taaaaaagaa attcttgact
    16861 tattttgatt tttggacata ttctatggga gatgctttta tttgtgtatc tgaaactatg
    16921 aaaaaaagat tggagagtat aataaaaaaa taagaagata gttgcaataa ataacggaat
    16981 taatgtatca aatagcgatt taaatgtagt aggtgttcaa gactttaaaa aagaattttg
    17041 tattccaaat aacaaaaaaa tcatttgtta tgttggaagg ttggatccag aaaaaaggcc
    17101 ggatagattc cttgaatttg cagaaaaatt atttttagtc agagaagatg tgatttttat
    17161 tatggctgga aatggtagta tgtgggctgc tttgaaagaa aaaatttgcc atttgaaatg
    17221 tagagataat ttcaggttac ttggtgaaat ctatccagct actatagttt accaaatatc
    17281 ggatttattg tatattcctt ctgatacaga aggaatacct atgtgtgttt tagagtcaat
    17341 gtcacaagga actccggttt tagctagtaa tattggcggg ttaagtgaaa ttattgaaca
    17401 tagggttgat ggatttttat ttgagaagga agatgttgag ggagtgtgtg cttgtgctaa
    17461 ttttttactc aatgattctg agtatttgaa atatataggt gagaatagta aatcaaaaat
    17521 aagaaaacat ttttctgtgc aaaaaatgtt tgtagaaacc atgagagtat atgatgaatt
    17581 attagagaag agtagtcatg gataggaata tagatcaaga attagtaagt attataatac
    17641 caacacataa taggtatgaa tctctgatta gagctgtgaa aagttgttta catcaaagtt
    17701 ataaaaatat cgaagttata attattgatg ataattatag taatgtaaat ttaagaaata
    17761 aaattatcca tcaatttggc tataccaatc atagaattaa gttaatttta agtaatgaag
    17821 atttaggtgc aactaatgcc agaaacatag gtatcaaaaa ttctagaggt aagtatatat
    17881 catttttaga cgatgatgat gaatatatgc cagatcgaat tttaaagttg atggcttgtt
    17941 ttaaaaagag tagaatgaag aatttagctt tagtttatag ttatggaata ataatttatc
    18001 caaatggtac acgagaagag gagaagaccg attttgttgg aaatcccttg tttgttcaaa
    18061 tggttcacaa tatagcaggt acgtcatttt ggttgtgtaa aaaagaggtg ctagaattaa
    18121 ttaatggttt tgagaaaata gattcacatc aggacggtgt tgttttatta aaactacttg
    18181 ctcaaggata ccaaattgat atagtgcgag aattcttggt gaattactac gctcacagta
    18241 aagaaaacgg tatcactgga gtgacacaaa aaacaattaa tgcagatgaa gaatattata
    18301 attactgtag gaaatatttt aatttattga gtttcaacga gagaatattg gttacaaaga
    18361 aatattattc tttaaacata aagcggttac tattaatagg agacaaatgc aaggctttaa
    18421 aagtaatcaa gaaggcaaga gaagaaaaaa tttttaacga atttcctttt ttggaatata
    18481 tgttattata tcattttggt tttttctatt gtatatatga caactatgtt caattaaaat
    18541 ttagaaagtg agaaactatt gtgtatacta ttataaaatc aaatataaaa aaatttagtt
    18601 tattaacgat atttattgtt gctggtcaat tattgctaat ttatgcagca actattaatg
    18661 ctctggtgtt gaatgaatta attgcgatga atttagagcg gtttttgaaa ttgtcaatct
    18721 accaaatgat tgtctggtgt gggataatat tccttgactg ggtagtgaaa aattatcagg
    18781 ttgaagtgat ccaagagttt aatctagaga ttcgaaatag agttgccaca gacatctcta
    18841 actctaccta tcaagaattt catagtaaat catcaggaac atatctttcg tggctaaata
    18901 atgatgttca gactttaaat gatcaggctt ttaaacaact ttttttagta ataaaaggaa
    18961 tttctggtac tatatttgca gttgtgactc ttaatcacta tcattggtca ttgactgtag
    19021 ccaccttgtt ttcattaatg attatgctac ttgtaccaaa aatctttgca tcgaaaatgc
    19081 gagaagttag tctaaattta actaaccaaa atgaagcttt tttaaaatct agtgagacta
    19141 tattgaatgg atttgatgtg ttagcgtcct tgaatctttt atatgtattg cctaagaaaa
    19201 ttaaagaagc aggaatttta ttaaagatgg ttatacaaag aaagacaact gtagaaacgt
    19261 tagcaggcgc tattagcttc tttctcaata ttttttttca gatatctctc gtttttttaa
    19321 caggctatct tgcaataaaa ggaatagtga aaattggtac tattgaagca ataggagcac
    19381 taacaggtgt tatttttaca gcgctaggtg aattaggagg tcaattatcc tctattattg
    19441 gtacgaagcc tattttttta aaattgtatt caattaatcc aattgagtca aataaaatga
    19501 atgatatcga accaaatgag gtgaatagag attttccgtt atatgaagca aaaaatattt
    19561 gctataagta tggagataaa gaaatattaa aaaacttaaa tttttgtttt caacgtaatg
    19621 aaaagtattt aattttaggt gaaagtggaa gcgggaaatc tacattatta aaattattga
    19681 atggcttttt gagagattat agtggagaat tgcgattctg cggggatgat ataaaaaaaa
    19741 cctcctattt aaatatggtt tcgaatgttc tatatgtaga tcaaaaagct tatttgtttg
    19801 aaggtacgat tagagataat attttattgg aagaaaatta tactgatgaa gaaatactac
    19861 agtctttaga gcaagttggt ttgagtgtaa aagattttcc taataacatt ttagattatt
    19921 atgttggtga tgatgggaga ttactatcag gagggcagaa acaaaaaatt actttagcta
    19981 gagggctaat tagaaataag agaatagtat taattgacga gggaacttct gctatcgata
    20041 ggagaacttc gttagcgatt gaacgtaaga tattagatag agaggatttg actgtcatta
    20101 ttgttaccca tgctccgcat ccggaactta aacaatattt tactaagata tatcaatttc
    20161 caaaggattt tatttaagaa tataggggag ggaaacatga gattctattg tgaagcttat
    20221 gaggtaatta ctgaagagaa aaaagtatca ttttttatgt agatgaaaaa cccttaaggt
    20281 atctgttatt tgactatata tttctactag ttctagctaa aaaaaaatat cccaatctta
    20341 tgaactgcac cccaaaagtt agatttattc tgtctaactt ttggggtgca gttcattttg
    20401 catagttttg gcattcatcc tagatatcca tataaaatgt ctgagattgt tgaaatgtct
    20461 aaaaaaatat cagatctaaa cgataaaaaa gaatttcaca aaaagaactg tgagttgagg
    20521 tttcaagata g
//
LOCUS       DAVLHC010000033        20056 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.033, whole genome shotgun sequence.
ACCESSION   DAVLHC010000033 DAVLHC010000000
VERSION     DAVLHC010000033.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 20056)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20056)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20056
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.033"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            137..1618
                     /locus_tag="VXE25_001454"
     CDS             137..1618
                     /locus_tag="VXE25_001454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001205273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEV0771899.1"
                     /translation="MRDLLSKKSHRQLELLELLFEHKRWFHRSELAELLNCTERAVKD
                     DLSHVKSAFPDLIFHSSTNGIRIINTDDSDIEMVYHHFFKHSTHFSILEFIFFNEGCQ
                     AESICKEFYISSSSLYRIISQINKVIKRQFQFEVSLTPVQIIGNERDIRYFFAQYFSE
                     KYYFLEWPFENFSSEPLSQLLELVYKETSFPMNLSTHRMLKLLLVTNLYRIKFGHFME
                     VDKDSFNDQSLDFLMQAEGIEGVAQSFESEYNISLDEEVVCQLFVSYFQKMFFIDESL
                     FMKCVKKDSYVEKSYHLLSDFIDQISVKYQIEMENKDNLIWHLHNTAHLYRQELFTEF
                     ILFDQKGNTIRNFQNIFPKFVSDIKKELSHYLETLEVCSSSMMVNHLSYTFITHTKHL
                     VINLLQNQPKLKVLVMSNFDQYHAKFVAETLSYYCSNNFELEVWTELELSKESLEDSP
                     YDIIISNFIIPPIENKRLIYSNNINTVSLIYLLNAMMFIRLDE"
     gene            1980..2981
                     /locus_tag="VXE25_001455"
     CDS             1980..2981
                     /locus_tag="VXE25_001455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000230206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEV0771900.1"
                     /translation="MVEQRKSITMKDVALEAGVSVGTVSRVINKEKGIKEVTLKKVEQ
                     AIKTLNYIPDYYARGMKKNRTETIAIIVPSIWHPFFSEFAMHVENEVYKRNNKLLLCS
                     INGTNREQDYLEMLRHNKVDGVVAITYSPIEHYLTSGIPFVSIDRTYSDIAIPCVSSD
                     NDAGGREAAKQLISKGCQHLAFVGGHNTTINETKRRRISFEKYVQEHKIPLSIFDLDE
                     TVTDYYGKLESFLEENSSIDGIFTINDFTALDVIEILKKNGKRIPHDVQIIGYDGIKM
                     AGDRDYLLSTIEQPLEEMAKEAVRILFDIIDGKTVNLQTILPVKFVEGKTTKNENKS"
     gene            3131..4048
                     /locus_tag="VXE25_001456"
     CDS             3131..4048
                     /locus_tag="VXE25_001456"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001084977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEV0771901.1"
                     /translation="MNSKAKQVSLWERIKKQKLLLLMTVPGLVLTFIFKYIPMYGVLI
                     AFKDYNPLKGILGSDWIGFSEFTKFISSPNFGILLANTLKLSIYGLLLGFLPPIILAI
                     MLNQLLSEKVKKRIQLILYAPNFISVVVIVGMIFLFFSVGGPINNFLSMFGMKADFLT
                     NPDFFRPLYIFSGIWQGMGWASTLYTATLVNVDPALVEAARLDGANIFQRIWHIDIPA
                     LKPIMVIQFVLAAGGIMNVGYEKAFLMQTSLNLPTSEIISTYVYKVGLVSGDYSYSTA
                     VGLFNAVINVVLLVAVNQIVKRMNNGEGI"
     gene            4059..4949
                     /locus_tag="VXE25_001457"
     CDS             4059..4949
                     /locus_tag="VXE25_001457"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000797960.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HEV0771902.1"
                     /translation="MKNSIMDTKFDRRILLLNKIIIVFIVLMTLLPLLYIVVASFMDP
                     KVLVSRGISFNPADWTVEGYQRVFSDQSILRGFINSLLYSFGFAALTVLLSVFTAYPL
                     SKKDLVGRRWINYFLIVTMFFGGGLVPTYLLVKELGMLNTPWAIIVPGAVNVWNIILA
                     RAYFQGLPEELVEAAVIDGANDLQIFFKIMLPLAKPIMFVLFLYAFVGQWNSYFDAMI
                     YIKDPNLEPLQLVLRKILIQSQPGQDMIGAQAAMNEMKRLAELIKYATIVISSLPLIV
                     MYPFFQKYFDKGIMAGSLKG"
     gene            4978..6594
                     /locus_tag="VXE25_001458"
     CDS             4978..6594
                     /locus_tag="VXE25_001458"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000669747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HEV0771903.1"
                     /translation="MKFKTFSKSAVLLTASLAVLAACGSKNTASSPDYKLEGVTFPLQ
                     EKKTLKFMTASSPLSPKDPNEKLILQRLEKETGVHIDWTNYQSDFAEKRNLDISSGDL
                     PDAIHNDGASDVDLMNWAKKGVIIPVEDLIDKYMPNLKKILDEKPEYKALMTAPDGHI
                     YSFPWIEELGDGKESIHSVNDMAWINKDWLKKLGLEMPKTTDDLIKVLEAFKNGDPNG
                     NGEADEIPFSFISGNGNEDFKFLFAAFGIGDNDDHLVVGNDGKVDFTADNDNYKEGVK
                     FIRQLQEKGLIDKEAFEHDWNSYIAKGHDQKFGVYFTWDKNNVTGSNESYDVLPVLAG
                     PSGQKHVARTNGMGFARDKMVITSVNKNLELTAKWIDAQYAPLQSVQNNWGTYGDDKQ
                     QNIFELDQASNSLKHLPLNGTAPAELRQKTEVGGPLAILDSYYGKVTTMPDDAKWRLD
                     LIKEYYVPYMSNDNNYPRVFMTQEDLDKIAHIEADMNDYIYRKRAEWIVNGNIDTEWD
                     DYKKELEKYGLSDYLAIKQKYYDQYQANKN"
     gene            6604..7923
                     /locus_tag="VXE25_001459"
     CDS             6604..7923
                     /locus_tag="VXE25_001459"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 32 protein"
                     /protein_id="HEV0771904.1"
                     /translation="MGDKKYTVEKANRFIAENKHLVNTQYKPEEHFSAEIGWINDPNG
                     FVYFRGEYHLFYQFYPYDSVWGPMHWGHAKSKDLVTWEHLPVALAPDQDYDRNGCFSG
                     SAIVKDDRLWLMYTGHIEEKTGVRQVQNMAFSDDGIHFEKIEQNPVATGADLPDELIA
                     ADFRDPKLFEKDGRYYSVVAAKHKNNVGCIVLLGSDNLVEWQFESIFLKGVEHQGFMW
                     ECPDYFELDGKDCLIMSPMRYQREGDSYHNINSSLLFTGKVDWGEKCFIPESVQEIDH
                     GQDFYAPQTLLDNQNRRILIAWMQTWGRTLPTHDQEHKWACAMTLPRILRLEDGKLRQ
                     FPVKKGQYQIQIDKDCHYHLGNDIDYLEFGYDSNAQQVYIDRSHLIQKILGEEEQDTS
                     RRYVDIEAKELEVVLDKNSIEIFVNQGEASLTATYYLTVPAELSRID"
     gene            complement(8132..8204)
                     /locus_tag="VXE25_001460"
     tRNA            complement(8132..8204)
                     /locus_tag="VXE25_001460"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(8169..8171),aa:Lys,seq:ctt)
     gene            complement(8469..9740)
                     /locus_tag="VXE25_001461"
     CDS             complement(8469..9740)
                     /locus_tag="VXE25_001461"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001113185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication-associated recombination protein A"
                     /protein_id="HEV0771905.1"
                     /translation="MPDNLALRMRPKTIDQVIGQEHLVGPGKIIRRMVEANRLSSMIL
                     YGPPGIGKTSIASAIAGTTKYAFRTFNATVDSKKRLQEISEEAKFSGGLVLLLDEIHR
                     LDKTKQDFLLPLLESGLVIMIGATTENPFFSVTPAIRSRVQIFELEPLSNQDVKEALQ
                     IALSNPERGFDFPIELDEDALDFIATSTNGDLRSAFNSLDLAVLSTPENDEGIRHITL
                     DIMENSLQRSYITMDKDGDGHYDVLSALQKSIRGSDVDASLHYTARLIEAGDLPSLAR
                     RLTVIAYEDIGLANPEAQIHTVTALDAAQKIGFPEARILIANVVIDLALSPKSNSAYV
                     AMDKALADLKTSGHLPIPRHLRDGHYSGSKELGNAQDYLYPHNYPGNWIKQDYLPEKI
                     RNHHYFQAEDTGKYERALAQRKEAIDRLRKI"
     gene            10010..10249
                     /locus_tag="VXE25_001462"
     CDS             10010..10249
                     /locus_tag="VXE25_001462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000818079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771906.1"
                     /translation="MKREVISNGNDGPSQEILIFTKQIRHWILSDQVISGKRKLFFRE
                     DTPKEILDLYENIKSKLDFAYQEVHSNNGLKKYEK"
     gene            10413..10592
                     /locus_tag="VXE25_001463"
     CDS             10413..10592
                     /locus_tag="VXE25_001463"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771907.1"
                     /translation="MNLIFEEYQFVKIGDKKYRVRSVPMIHSTPPQSVLDRDTFTIDY
                     TDDELLDKEAVFTTH"
     gene            10729..10908
                     /locus_tag="VXE25_001464"
     CDS             10729..10908
                     /locus_tag="VXE25_001464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397531.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system HicA family
                     toxin"
                     /protein_id="HEV0771908.1"
                     /translation="MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGE
                     LNKYTERGIRKQAGL"
     gene            10945..11397
                     /locus_tag="VXE25_001465"
     CDS             10945..11397
                     /locus_tag="VXE25_001465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000961815.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system HicB family
                     antitoxin"
                     /protein_id="HEV0771909.1"
                     /translation="MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAM
                     GSEWLGITVADLIESDGELPQPSDINSLSLIDNDPFKDDEDFVSTYDLDKSFISMVSV
                     DVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA"
     gene            11688..12158
                     /locus_tag="VXE25_001466"
     CDS             11688..12158
                     /locus_tag="VXE25_001466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000257105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3013 family protein"
                     /protein_id="HEV0771910.1"
                     /translation="MATYGFLDILEEELDKNFPFDFEISWDKRNHAVEVSFLLEAQNA
                     AGVEMVDEDGEVSSDDILFEEAVLFYNPAKSTVNEEDYLTVIPYLPKKGFSREFLAYF
                     ALFLKDTAEVGLDVLMDFLEDPEAEEFVMEWNQEVFEEGKVGLEEGEFYPYPRY"
     gene            12177..13265
                     /locus_tag="VXE25_001467"
     CDS             12177..13265
                     /locus_tag="VXE25_001467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000719715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-2 protease family protein"
                     /protein_id="HEV0771911.1"
                     /translation="MKKIGTYLVYVLAVVFIMLAFACGTIAFAELGYSAVLAFTFGYA
                     FALLSMYLIFILHELGHAFCGYLTGYRLVAFGLGHFILTKKSGRFHLSRTAILKNVGA
                     QYIGLKEDESDQRIILMLSGGLMVHLGLILLAIVFGFLTRSWYFAGTWIFLNLSFFLN
                     NILPVDITDGAKIWELLQHPENTKYAYLVLRHSAQTLLVPQEYDLKDFVQAVPEDARG
                     SFADGVLGMQGEVSILEGKEEVAKQQFQALLERTTTPMMQTVAQLSLLHIALLEGDFE
                     QAEQYASIRQVKSFLSLKLSNLQVIQAWYQLKVKKDVDRTRKALKIARQKMDSSRMLR
                     DEKRYYENLLAELEKEMLEGTEDGTRNF"
     gene            13246..13674
                     /locus_tag="VXE25_001468"
     CDS             13246..13674
                     /locus_tag="VXE25_001468"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HEV0771912.1"
                     /translation="MELEISDFLGCKIALFCGDKLLTILRDDKASIPWANMWELPGGG
                     REGDESPFECVAREVYEELGIHLTEDCLLWSKIYPSMLFADKQSVFLVGQLTQNQFDS
                     IVFGDEGQGYQLMNVEEFLSSSQVVPQLQERLKDYLKVSD"
     gene            13812..14762
                     /locus_tag="VXE25_001469"
     CDS             13812..14762
                     /locus_tag="VXE25_001469"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000451122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L11 methyltransferase"
                     /protein_id="HEV0771913.1"
                     /translation="METWQELKVTVKREGEELVSNLLIELGAQGVAIEDSMDYMGNVD
                     RFGEIFPEVEQQEEIVVTAYYPDTVDVTVVEADLQARLAELTDFMDLGEVKMGTTALA
                     EEDWADNWKKYYEPARITHDLTIVPSWTDYEATAGEKIIKLDPGMAFGTGTHPTTKMS
                     LFALEQVLRGGETVLDVGTGSGVLSIASSLLGAKEIFAYDLDDVAVRVAQENIELNPG
                     MENIHVAAGDLLKGVEIEADVIVANILADILIHLTDDAYRLVKDEGYLIMSGIIKDKW
                     DMVRESAESAGFFLETHMVQGEWNACVFKKTKDISGVIGG"
     gene            14764..15507
                     /locus_tag="VXE25_001470"
     CDS             14764..15507
                     /locus_tag="VXE25_001470"
                     /EC_number="2.1.1.193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001188214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (uracil(1498)-N(3))-methyltransferase"
                     /protein_id="HEV0771914.1"
                     /translation="MQQYFVKGSAISPVTIEDKETSKHMFQVMRLKEEDEVTLVFDDG
                     IKRLARVLDMENRQFELVQELNDNVELPVQVTIASGFPKGDKLEFIAQKVTELGASQI
                     WAFPADWSVAKWDGKKLGKKVEKLEKIALGAAEQSKRNIVPSIKLFEKKADFLTQLDQ
                     FDSIIVAYEESAKEGEAAALLQAVTGLETGAKLLFIFGPEGGLSPAEIESFEAKGAVL
                     VGLGPRILRAETAPLYALSALSVLVELEK"
     gene            15518..17314
                     /gene="pepF"
                     /locus_tag="VXE25_001471"
     CDS             15518..17314
                     /gene="pepF"
                     /locus_tag="VXE25_001471"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000435555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oligoendopeptidase F"
                     /protein_id="HEV0771915.1"
                     /translation="MEQKHRSEFPEKELWDLTALYQDREDFLRAIEKAREDINQFSRD
                     YKGNLHTFEDFEKAFAELEQIYIQMSHIGNYAFMPQTTDYSNDEFANIAQAGMEFETD
                     ASVALTFFDDALVVADEEVLDRLGELPHLTAAIRQAKIKKAHYLGADVEKALTNLGEV
                     FYSPQDIYTKMRAGDFEMADFEAHGKTYKNSFVTYENFYQNHEDAEVREKSFRSFSEG
                     LRKHQNTAAAAYLAQVKSEKLLADMKGYDSVFDYLLAEQEVDRVMFDRQINLIMKDFA
                     PVAQRYLKHVAKVNGLEKMTFADWKLDLDSALNPEVTIDDAYDLVMKSVEPLGQEYCQ
                     EVARYQEERWVDFAANSGKDSGGYAADPYRVHPYVLMSWTGRLSDVYTLIHEIGHSGQ
                     FIFSDNHQSYFNAHMSTYYVEAPSTFNELLLSDYLENQSNDPRQKRFALAHRLTDTYF
                     HNFITHLLEAAFQRKVYTLIEEGETFGASKLNSIMKEVLTDFWGDAIEIDDDAALTWM
                     RQAHYYMGLYSYTYSAGLVISTAGYLHLKNSETGAEDWLNLLKSGGSKTPLESAMIIG
                     ADISTDKPLRDTIQFLSDTVDQIIAYSAELGE"
     gene            complement(17374..18051)
                     /locus_tag="VXE25_001472"
     CDS             complement(17374..18051)
                     /locus_tag="VXE25_001472"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000433071.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEV0771916.1"
                     /translation="MEPDIFIITKLLSDPSRMHILDILMDGKAHTVNEIASFTKIKQH
                     TVSYHLKLLTEAQVTTLQTYGRFHYYSLKSAAIAEMLEFLSFYSPQRDVKSYKQHIHK
                     KELKVARTCYDHIAGELGISITNYLLQENLLSESEKDFQLTEAGKSYFQRKLHIDTDE
                     LKKKKRKFCPKCLDWSERKNHVGGALGNALLEFFSEKQLVIPAQTPRSLTITEKGKEF
                     LEKEWGI"
     gene            18298..19068
                     /locus_tag="VXE25_001473"
     CDS             18298..19068
                     /locus_tag="VXE25_001473"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000966490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0771917.1"
                     /translation="MLYLWGKERVKKLSVKNLKKQYGSYEAVKGISFELGDGECLGIL
                     GINGAGKTSTLKMIYSLTSISSGEIDILGQNIETNRRKSKSCLGIVGQEDMLDMTLNV
                     YDNLFAHGLCYGISSVELRKRIDSLLDFVQLSKHAQKMVNQLSGGMRRRLVLARALIN
                     RPDIIILDEPTVGLDIQSRNIIWDKLLELKELGVSIIITSHYMNEIEYLTDRVLMLHQ
                     GTIKEEGTVEDLLIKYDADNLETLFWGLTGTEKEDLHV"
     gene            19061..19825
                     /locus_tag="VXE25_001474"
     CDS             19061..19825
                     /locus_tag="VXE25_001474"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEV0771918.1"
                     /translation="MFKLSFHSIGHVVVRNYMSFRNLFKISIVPNLIDPLFYLLAMGF
                     GVGAYLTHVNGMLYRDFVITGLIAATAMSAATAETTVNAFIQYKIEKTYDAMLMTPIN
                     TNDIVVGQAIWAGIRAVIFGGIFWLISMLITAHFHVLMLLIPLILFIVGYLFGVLGLI
                     FTYLAPSREFLNYYNVLVIRPLYMFSDTFFPITSLPPILGDLTWFSPLYHATRMIRII
                     WGGEVTGLYLHLIWLIALALLITVLPMYMLHRRYYR"
BASE COUNT         6147 a         3426 c         4346 g         6137 t
ORIGIN      
        1 ttatatattg tctccgtagt gttattatac gaaataaaag attttaggaa aagtcgttat
       61 atcatgctat acctattctt tgtggtataa ttgcaagagg tttaatccga taatttataa
      121 agagagaaag atattcatga gagatttatt atctaaaaaa agtcataggc aattagaatt
      181 attagaatta ttatttgaac ataaacgttg gtttcatcgt tctgaactag cagagttatt
      241 aaattgtaca gaacgtgcag tcaaagatga tctatcccat gttaaatctg cttttcctga
      301 cttgattttt cattcttcta ctaatggtat acgcattatt aataccgatg atagtgatat
      361 tgaaatggtt taccatcatt tctttaaaca ttcaactcat ttttcgattt tagaattcat
      421 cttctttaat gaaggttgtc aagctgagag tatttgtaaa gaattttata tcagttcatc
      481 ttcgctctat cgtattatta gccaaatcaa taaagtgatt aaaaggcaat ttcaatttga
      541 agtcagtctg acccctgttc aaatcattgg aaatgagaga gacattcgtt acttttttgc
      601 acaatatttt tcagaaaaat attatttcct agaatggcca tttgaaaatt tttcatcaga
      661 gccactatct caattgttag aattggttta taaggaaaca agctttccaa tgaatttgtc
      721 aacgcataga atgctaaagt tgctcctagt tacgaaccta tatagaataa agtttggtca
      781 ttttatggaa gtagataaag attcttttaa cgaccaaagt ttggattttt taatgcaggc
      841 agaaggaata gaaggtgttg ctcagagttt tgaatcagaa tacaatatct ctttagatga
      901 agaagttgtt tgccaattat ttgtgtctta ctttcaaaaa atgtttttca tagatgaaag
      961 tctctttatg aaatgcgtaa aaaaggatag ttatgttgaa aaatcttacc atctattgag
     1021 tgattttatt gatcagattt cagtcaagta tcagattgaa atggagaata aggataatct
     1081 gatttggcat ctgcataata ccgcacatct gtatcgtcaa gagttgttta ctgagtttat
     1141 tttatttgat caaaaaggga atacaatcag gaactttcaa aatatttttc caaaatttgt
     1201 ttcagatata aaaaaagagc tttctcacta tttagagact cttgaggttt gttctagttc
     1261 aatgatggta aatcatctat cttatacctt catcactcat accaaacatt tggtgattaa
     1321 tttgctacaa aatcagccta aactaaaggt tttagttatg agtaattttg atcagtatca
     1381 tgcaaaattc gttgcagaga cactttctta ttactgtagc aataattttg aactggaagt
     1441 ttggactgaa ttagaattat caaaggaatc tttagaagat tcaccttatg atatcattat
     1501 ttctaatttt attattcctc ctattgaaaa taagagactc atctattcaa ataatataaa
     1561 cacggtctca ctcatatact tgttaaatgc catgatgttt attcgattag atgagtaagc
     1621 aaaaataaca aaaaaacgct atttcgcgtt tgaactgtac ctcaaaagtt agacagaaaa
     1681 aatctaattt ttggggtgtt tttgttaaga aaagaccttc aatcatttaa gcaaaatgta
     1741 catctagatt tatagccctc taaaactctt gctttttttg tagaagatac gaaaaaagcc
     1801 ataaaaccaa ggcttttcct gttttatgta gatgtttaca catgaaaatt gaagtatttt
     1861 caaaagctaa ttggagtgat tttattcatg atgggataaa tgatctggcc aaaaatgatt
     1921 gagaaatagt tgcttaaaaa gcatttgcat gatactatat attgaaagga ggtgataata
     1981 tggtagaaca aagaaaatca attaccatga aagatgttgc tttagaagca ggagttagtg
     2041 ttggaactgt ttcacgtgta attaataaag aaaaaggcat taaagaagta actttgaaaa
     2101 aagtggaaca agcgattaaa actttgaatt acattccaga ttactacgct agaggaatga
     2161 aaaaaaatcg aacagaaacg attgcaatca ttgtaccaag tatctggcat cccttctttt
     2221 cagaatttgc tatgcatgtg gaaaatgaag tctataagag aaataacaaa ttactcttat
     2281 gttctatcaa tggtacaaat agagagcaag actatctgga gatgttgcgt cataataaag
     2341 ttgatggagt ggttgccatt acctatagtc caattgaaca ttacttgacg tcaggaattc
     2401 cctttgttag tattgaccgc acatactcag atattgccat tccttgtgtt tcatcagata
     2461 atgatgcagg tggaagagaa gcagctaaac aattaattag taaaggatgt cagcatttag
     2521 cctttgtggg cggacataat acaaccatta atgaaaccaa acgtcgtaga atttcatttg
     2581 aaaagtatgt ccaagagcat aaaatacctc ttagtatttt tgatttggat gagacagtta
     2641 ctgactatta tggaaagcta gagagtttct tggaagaaaa ttcttctata gatggaattt
     2701 ttacaatcaa cgattttaca gctttggatg tgattgaaat actaaaaaaa aatggcaaac
     2761 gtattcctca tgatgtccaa attattggat acgatggaat taaaatggct ggagatagag
     2821 attatctact ttcaactatt gaacaaccat tggaagaaat ggcaaaagaa gcggttcgta
     2881 ttttgtttga tataattgat ggaaagactg ttaatttgca gacaatccta ccagtaaaat
     2941 ttgttgaagg aaaaacaaca aaaaatgaaa ataagtcttg acagaaagcg ctatcaatga
     3001 tagaatgaat tcagataaaa agatttattt ttaaaacaaa aatgaaacgt ttcaaaaaag
     3061 aaataaaaag acagcgccaa gcgctatctt ttctagaaaa aaatgaaacg tttcaaaaaa
     3121 ggaggttgct atgaatagca aagcgaagca agtttctctt tgggaaagaa tcaagaaaca
     3181 aaaactcttg ttattgatga ctgtccccgg tttagtttta acctttatct ttaaatacat
     3241 ccctatgtat ggggttttaa tcgcatttaa agattacaat cctttaaaag gaattttagg
     3301 gagtgattgg attggttttt ctgagtttac aaaattcata tcctctccca actttggtat
     3361 cttgttagcc aacacattaa aattaagtat ctatggttta ttgcttggct ttttaccacc
     3421 aatcattctt gcgattatgc tcaatcaact cttgagtgaa aaagtcaaaa aacgaattca
     3481 gctcatttta tacgcaccaa actttatctc agtcgttgtt attgtcggta tgattttcct
     3541 cttcttttca gtgggaggac caatcaacaa ttttctttct atgtttggaa tgaaggctga
     3601 cttcttgaca aatccagact tctttagacc cttatacatc tttagtggta tctggcaagg
     3661 aatgggctgg gcttcaacgc tctacacggc aacattggta aatgtagatc cagccttagt
     3721 agaagcagct cgactggatg gagccaatat cttccaacga atctggcaca ttgatattcc
     3781 agctcttaag cctattatgg ttatccaatt tgttttagct gcaggtggaa ttatgaatgt
     3841 cggatatgaa aaagcattct tgatgcagac atcgttaaat ttgccaactt ctgaaattat
     3901 ctcgacatat gtctataaag ttggtcttgt atcaggagac tattcttact caacagcggt
     3961 tggtttgttt aatgcagtga ttaacgtagt attgcttgtt gcagttaacc aaatcgttaa
     4021 acgcatgaat aatggtgaag gaatttaagg aggaaagtat gaaaaattcg attatggata
     4081 caaaatttga tagacgtatc ttactcttaa ataaaatcat tattgtcttt atcgttttga
     4141 tgactttgct tcctttactt tatatcgtcg tagcatcctt tatggatcct aaggttctgg
     4201 ttagtagagg gattagcttt aatccagccg attggactgt agaaggttac cagcgtgtat
     4261 tcagtgacca atctattcta agaggtttta tcaattctct actatactct tttggatttg
     4321 cagctttaac agtcttgcta tctgtgttta cagcttatcc tctttccaaa aaagatttgg
     4381 tagggcgccg ttggattaac tacttcttga ttgtgactat gttctttggt ggtggtttag
     4441 tcccaactta cttgctcgta aaagaattgg gaatgctcaa tactccatgg gctatcattg
     4501 ttccaggtgc tgtcaacgtt tggaatatta ttcttgctag ggcctatttc caaggattgc
     4561 ctgaagaatt agttgaagct gctgtcattg atggtgcaaa tgatttacag attttcttca
     4621 aaatcatgct tcctcttgca aaaccaatta tgtttgttct cttcctttat gcttttgtag
     4681 gacagtggaa ctcatacttt gatgcaatga tttatatcaa ggatccaaac ttggaaccat
     4741 tgcaacttgt acttcgtaaa attctcattc agagccaacc aggtcaagac atgattggag
     4801 cacaagcggc tatgaatgaa atgaaacgtt tagctgaatt gattaaatac gcaactattg
     4861 tcatttccag cttgccattg attgttatgt atccattctt ccaaaaatac tttgataaag
     4921 gaattatggc tggttcactt aaaggataaa aaaagaaaaa ataaaaggag ttttctcatg
     4981 aaattcaaaa cattctcaaa atcagcagtt ttgttgacag ctagtttagc agtacttgca
     5041 gcctgtggct caaaaaatac agcttcaagt ccagattata agttggaagg tgtaacattc
     5101 ccgcttcaag aaaagaaaac attgaagttt atgacagcca gttcaccgtt atctcctaaa
     5161 gacccaaatg aaaagttaat tttgcaacgt ttggagaagg aaactggcgt tcatattgac
     5221 tggaccaact accaatccga ctttgcagaa aaacgtaact tggatatttc tagtggtgat
     5281 ttaccagatg ctatccacaa cgacggagct tcagatgtgg acttgatgaa ctgggctaaa
     5341 aaaggtgtta ttattccagt tgaagatttg attgataaat acatgccaaa tcttaagaaa
     5401 attttggatg agaaaccaga gtacaaggcc ttgatgacag cacctgatgg gcacatttac
     5461 tcattcccat ggattgaaga gcttggagat ggtaaagagt ctattcacag cgtcaacgat
     5521 atggcttgga ttaacaaaga ttggcttaag aaacttggtc ttgaaatgcc aaaaactact
     5581 gatgatttga ttaaagtcct agaagctttc aaaaacgggg atccaaatgg aaatggagag
     5641 gctgatgaaa ttccattttc atttattagt ggtaacggaa acgaagattt taaattccta
     5701 tttgctgcat ttggtatagg ggataacgat gatcatttag tagtaggaaa tgatggcaaa
     5761 gttgacttca cagcagataa cgataactat aaagaaggtg tcaaatttat ccgtcaattg
     5821 caagaaaaag gcttgattga taaagaagct ttcgaacatg attggaatag ttacattgct
     5881 aaaggtcatg atcagaaatt tggtgtttac tttacatggg ataagaataa tgttactgga
     5941 agtaacgaaa gttatgatgt tttaccagta cttgctggac caagtggtca aaaacacgta
     6001 gctcgtacaa acggtatggg atttgcacgt gacaagatgg ttattaccag tgtaaacaaa
     6061 aacctagaat tgacagctaa atggattgat gcacaatacg ctccactcca atctgtgcaa
     6121 aataactggg gaacttacgg agatgacaaa caacaaaaca tctttgaatt ggatcaagcg
     6181 tcaaatagtc taaaacactt accactaaac ggaactgcac cagcagaact tcgtcaaaag
     6241 actgaagtag gaggaccact agctatccta gattcatact atggtaaagt aacaaccatg
     6301 cctgatgatg ccaaatggcg tttggatctt atcaaagaat attatgttcc ttacatgagc
     6361 aatgacaata actatccaag agtctttatg acacaggaag atttggacaa aattgcccat
     6421 atcgaagcag atatgaatga ctatatctac cgtaaacgtg ctgaatggat tgtaaatggc
     6481 aatattgata ctgagtggga tgattacaag aaagaacttg aaaaatacgg actttctgat
     6541 tacctcgcta ttaaacaaaa atactacgac caataccaag caaacaaaaa ctagaggttg
     6601 attatgggag ataagaaata cacagtagaa aaagccaatc gttttatagc agaaaataaa
     6661 catctcgtta atactcaata taagcctgaa gaacattttt cagctgagat tggttggatc
     6721 aatgatccaa atggatttgt ctattttcgt ggagaatacc atctctttta tcaattctat
     6781 ccatatgata gtgtttgggg acctatgcac tggggacatg ctaaaagtaa ggacttggtg
     6841 acttgggagc acttgccagt ggcacttgct cctgaccaag attatgaccg aaatggttgt
     6901 ttctcaggct ctgccattgt caaggatgat cgcctctggc tcatgtacac tgggcatatc
     6961 gaagaaaaaa ccggtgtccg ccaagtgcaa aatatggcat tttcagacga cgggattcac
     7021 tttgaaaaga ttgaacaaaa tccagttgca actggagcag acttgccaga tgagttgatt
     7081 gctgctgatt tccgtgatcc aaaactcttt gaaaaagatg gacgctatta ctccgtagta
     7141 gctgccaaac acaagaataa tgtgggctgt atcgttctac tagggtccga taacctagta
     7201 gaatggcagt tcgaatccat ctttttaaaa ggggtagaac accaaggctt tatgtgggaa
     7261 tgcccagatt acttcgagtt agatgggaaa gattgcctta ttatgtcacc catgcgttat
     7321 cagcgtgagg gagactcata tcataacatc aactcatcgc ttttgttcac gggtaaggta
     7381 gattggggag aaaaatgttt tatcccagaa tcagttcaag aaattgatca tggccaagac
     7441 ttctatgcgc ctcaaacatt gttggacaat caaaatcgtc gtatcctgat tgcttggatg
     7501 cagacatggg ggcgtaccct tccaacccat gaccaagaac acaaatgggc atgtgccatg
     7561 actttaccta gaattctaag attggaagat ggcaaactaa gacaattccc tgttaaaaaa
     7621 ggccaatatc aaatccaaat agataaagat tgtcattacc acttaggaaa tgatatagat
     7681 tatcttgaat ttggttatga cagtaatgcg cagcaagttt acattgatcg tagccatctt
     7741 attcaaaaaa ttctaggtga agaagaacag gacactagtc gacggtatgt agatattgaa
     7801 gctaaagaat tggaagttgt tctagataaa aattccatcg agatttttgt caatcaaggt
     7861 gaagcaagct tgactgcaac ttattactta acggtgccag ctgagctatc acgaattgat
     7921 taaaaattaa gttatttctc ctaaagaaaa agttctcttt ctaaaatagt ggaaagagga
     7981 ctttttgtgt tttgggtata taagcttagt ttatggtatt tgtaaaattg gtgttggatt
     8041 atgatttaaa ctagttttct aaagaatttg aaaaaaattt tatttaagca aaaaaaacct
     8101 tggttccaag acttttcctg ttgtatttag atgcccccta cagggatcga acctgtgacc
     8161 cacggattaa gagtccgctg ctctgccagc tgagctaagg aggcaaagaa aaaagctgta
     8221 ttggtgccga aacttcacgg tttgtattga acccgcgcaa ttaagcaggt gggcaactcg
     8281 ctctaactga agctgtttcc gtgtgagacg gcctacatgc tgttagaaga cttttgtttc
     8341 cctaataata caaaaaatag tcggtcaaca cttaagtgtg aagtcgtaca ccacagcgtt
     8401 tctatactta tatgatacca ctttttcaaa aaaaatcaag aggaaagtgc aattttttga
     8461 aaaggatttc agatttttcg caaacgatcg atagcttcct ttctttgagc caaagcccgt
     8521 tcatatttac cagtatcttc tgcttggaaa tagtgatgat tacgaatttt ttctggcaga
     8581 tagtcttgct tgatccaatt tccaggatag ttgtgtggat agagatagtc ttgggcattc
     8641 cccagttcct tgcttccact gtagtgccca tcacgcaggt gtcgcggaat aggcaagtgc
     8701 cctgatgttt tgaggtcagc aagtgcctta tccatagcta cataggctga gttggatttt
     8761 ggagaaaggg ccaaatcaat cacgacattg gcaatgagaa tgcgggcttc tgggaaccca
     8821 atcttctggg cagcatccag agcagtcacg gtatgaatct gggcctcagg attggctaag
     8881 ccgatatctt cataggcgat aacagtcaag cgacgagcga gactaggcag atccccagcc
     8941 tcaatcaagc gggcagtata gtggagactg gcatccacat ctgagccacg aatagacttt
     9001 tgcagggcag atagaacatc atagtgaccg tctccatcct tgtccatagt gatgtagctt
     9061 ctctgaagac tattttccat gatgtctaag gtgatgtggc gaatgccctc gtcattctca
     9121 ggggtagaga gaacagccaa gtccagtgag ttaaaggcag agcgaaggtc tccgtttgta
     9181 gaggttgcga tgaaatccag cgcatcctca tctagttcta ttggaaaatc aaaaccacgt
     9241 tcagggttac ttagagctat ctgcagggcc tctttgacgt cttggttaga cagaggttcc
     9301 aactcgaaaa tttgaacacg gctacgaatg gcaggagtga cagagaagaa aggattttca
     9361 gtcgttgctc caatcatgat gaccagtcca ctttccaaga gaggcaagag gaagtcttgc
     9421 ttggtcttat ctagtcgatg aatttcgtct agcaatagga cgagaccacc agaaaattta
     9481 gcttcttccg agatttcttg cagtcgcttt ttactatcaa ctgtcgcatt gaaagttcga
     9541 aaggcatact tggtcgttcc agcgatggca gaggcaatac tggttttgcc gattcccgga
     9601 gggccatata gaatcatgga ggacaggcgg ttggcttcca ccatgcggcg gatgattttt
     9661 ccaggtccga ccagatgctc ctgaccgatg acctggtcga tggttttagg gcgcatgcga
     9721 agcgcgagat tgtctggcat agcagtcctt tctaacgtgg atttgagtag aatgactcat
     9781 ctactatatc ttactatgtc cattctagcc tattagttgt gatatttcaa tggttttgta
     9841 ataatcaggg agtgagatag aatctttttt actatttaat ttaatgagga gaggtatcag
     9901 catgagagat ttgattttcc ttaaagctca aaataggata gttgagccta aagaagtgga
     9961 agtgctgact tgagaaataa tattgctgaa tgtcattgta tgaactataa tgaaaagaga
    10021 ggtgataagc aatggaaatg atggaccaag tcaggaaatt ttgattttta caaaacaaat
    10081 tcgtcattgg attcttagtg atcaagttat ttcagggaaa agaaaacttt tcttccggga
    10141 agatactcca aaagagattt tagatttgta cgaaaacatt aaatctaaac ttgattttgc
    10201 ttaccaagaa gttcattcta ataatgggtt gaaaaaatat gaaaaataga ataattgatg
    10261 ttttgaagta gtaaatcgcc tccttgtact aactgttgaa aatcctgatt tcgaagactt
    10321 gagagttaat catactcaat gaaaatcaaa gagcaaacta ggaaactagc cgcaggctgt
    10381 acttgagtac ggtaaggcga cgttgacgtg gtttgaattt gattttcgaa gagtatcagt
    10441 ttgtaaaaat tggagataaa aaatatagag tacgcagtgt tcctatgatt cattcaactc
    10501 cgcctcaatc tgtcttagat cgagatactt ttacaattga ctatacagat gatgaattgc
    10561 tcgataaaga agcagttttt actactcatt agaaaaatag gtctgaataa attggcttcc
    10621 cttagaacca catctagggg cttttatgta taatagaata ataagtatca ctcctttaca
    10681 atacgtgtaa cacgtgttat aatggtgttg tcaggaggta aaagcgctat gcctatgaca
    10741 caaaaagaga tggttaaact ccttacggcc catggttgga taaagactag aggcggtaaa
    10801 ggctcccata ttaaaatgga gaagcaaggg gaaagactta tcacaatccc tcatggtgag
    10861 ctgaataagt acactgaaag agggataaga aagcaagctg ggttgtaaaa ttcagcccct
    10921 gttttttgat atggaggtag tgaaatgtta gttacgtatc cagctttatt ttattatgac
    10981 gacacagacg gaacagaagc gacttatttt gtccatttcc cagattttga atactcagct
    11041 acacaaggag aggggatttc tgaggctttg gctatggggt cggagtggct agggataact
    11101 gttgcagatt tgatagagag tgatggagag ttacctcagc catcagatat caatagcttg
    11161 tctttaattg ataatgatcc ttttaaagat gatgaagatt tcgtgtcaac ctatgacctt
    11221 gataaatctt ttatttctat ggtatctgtt gatgtatcag aatacctagg aagtcaggaa
    11281 cccattaaaa agactttgac cataccaaaa tgggcagata agttgggacg agaaatggga
    11341 cttaactttt ctcagacttt gacagacgct attgcagata agaaagttca agcctaagat
    11401 taagcgtggt atcgtggtaa tagtcaataa aaaagcacgt ccacttgtgc tagttactcg
    11461 cctattgatt ttatagattt attagccctt tcgagggctt tttatattga tttttatgag
    11521 aaatgaagaa atcagacttt taagaaaatc actgatacca agggtttaaa tgaggtaata
    11581 tggtataatt aggacataaa ataattttgt ggtaagatgg tagtatctat tttagcatat
    11641 ttccgagcaa tcggggcgat taaagagtcg catagaaaga ggacaaaatg gcaacatacg
    11701 gatttttaga tattttagag gaagagttgg acaagaactt tccctttgac tttgagatta
    11761 gttgggacaa acgcaaccat gcggtagaag tgagttttct attggaagcg caaaatgctg
    11821 caggtgtgga gatggtggat gaagacggag aggtttcatc agatgacatt ctttttgagg
    11881 aagcggtcct tttctacaat cctgccaagt caacagtcaa tgaggaagac tatttgactg
    11941 ttattcctta cctgcctaaa aaaggatttt cccgtgaatt tttagcttat tttgcgcttt
    12001 tccttaaaga tactgctgag gttgggctag atgtcctcat ggactttttg gaagacccag
    12061 aagcagagga atttgtcatg gaatggaacc aagaagtctt tgaagaagga aaagttggct
    12121 tggaagaggg agaattttac ccttatccaa gatactagga gttggttgga ggtgttatga
    12181 agaaaattgg gacttatttg gtttatgtgc tagctgttgt ctttattatg ctagcttttg
    12241 cttgtggaac aatcgcattt gcagagttgg ggtattccgc agttttagcc tttacttttg
    12301 gttatgcctt cgctcttcta agcatgtatt taatctttat tcttcatgag ctgggtcatg
    12361 ctttttgtgg ctacttgaca ggctatcggc tggtggcttt tggattagga cattttattt
    12421 tgaccaaaaa gtcaggcagg tttcatctta gtagaacagc cattctgaaa aatgttggtg
    12481 ctcaatacat tggtttaaaa gaggatgaaa gcgatcaaag aatcatcctg atgctttcag
    12541 gaggcttgat ggttcatctc ggcttgatat tattggcgat agtgtttgga tttttgacaa
    12601 gaagctggta ttttgcaggg acttggattt ttcttaattt atctttcttc ctaaataaca
    12661 ttttgccagt cgacatcacc gatggagcaa aaatttggga attactacaa caccctgaaa
    12721 ataccaaata cgcctacctg gtattgagac attctgctca aactttgctg gttcctcaag
    12781 aatatgattt gaaagacttt gttcaagcag ttcctgagga tgcacgaggg agttttgcgg
    12841 atggtgtatt aggtatgcaa ggtgaagttt ccattttgga agggaaggaa gaagtagcta
    12901 aacagcagtt tcaagcatta cttgagagga caactactcc gatgatgcag acagttgccc
    12961 aactatccct gcttcatatc gccttgttgg aaggagattt tgagcaagcg gagcaatatg
    13021 ctagtattcg acaggtcaaa tcgtttctgt ctctcaaact gtccaatctt caagtgatac
    13081 aagcctggta tcaattaaag gtgaagaaag atgtagatcg aactcgtaag gctctcaaga
    13141 ttgctagaca gaaaatggat agtagtcgaa tgttgaggga cgagaaacgc tattatgaaa
    13201 acttgttagc agagctggaa aaggaaatgt tagaaggaac tgaagatgga actagaaatt
    13261 tctgatttcc taggctgtaa gattgctttg ttttgtgggg ataagctttt gactatctta
    13321 cgcgatgata aggcaagcat tccctgggcc aatatgtggg aactgccagg tggtggacgt
    13381 gaaggtgatg aaagtccttt tgagtgtgta gcgcgtgaag tttatgaaga actgggcatt
    13441 catctgactg aagattgtct gctttggagt aagatttacc caagtatgct ttttgcagac
    13501 aaacagtccg tttttctagt tggtcagttg acacagaacc agtttgacag tatcgtattt
    13561 ggagatgaag gacagggcta tcagctgatg aatgttgagg aatttcttag ttccagtcaa
    13621 gttgtgcctc agttgcaaga gagattaaaa gattatttaa aagtaagtga ttagaaagga
    13681 tggttcggtt aaatttctaa actgaacccg ccctaaacac ggtgccaaaa agataaactt
    13741 ctcttagaca caaacgtctt cagagaattt cctattttgg ttttgtgttt tacgggcttg
    13801 gtatcttaat aatggaaaca tggcaagagt taaaagttac agtgaagcgt gagggagagg
    13861 agttggtttc caatctcttg attgagctag gagcgcaagg agtcgcaatc gaagacagta
    13921 tggactatat gggaaatgtg gatcgttttg gcgagatttt cccagaggtg gagcagcaag
    13981 aagaaatcgt agtgacagcc tactaccctg acacggtgga tgtgacagtg gttgaggcgg
    14041 acttgcaggc tcgcttagca gaattgacgg attttatgga tttgggtgaa gtcaagatgg
    14101 ggacgactgc cttggctgag gaagactggg cagacaactg gaagaaatac tatgagccag
    14161 ctcgtatcac tcatgatttg accatcgttc cctcttggac agactatgag gcgactgcgg
    14221 gagaaaaaat tatcaagcta gatcctggga tggcttttgg tactgggacc catccaacta
    14281 ccaagatgag cctctttgcc ttggaacagg ttcttcgtgg tggcgagaca gtgctagatg
    14341 tggggactgg ttcaggggtt ctctccattg ctagctcgct acttggtgcc aaggaaatct
    14401 tcgcctatga cctagatgat gtagcagttc gtgttgctca ggaaaatatt gaacttaacc
    14461 ctggaatgga aaatatccac gttgctgctg gagacttgct taagggtgtt gagattgagg
    14521 cagatgtgat tgtagctaat atcttggcgg atattctcat tcatctgaca gacgatgcct
    14581 atcgtttggt caaggatgaa ggctacctga tcatgagtgg cattatcaag gacaagtggg
    14641 acatggtgcg cgagtcggct gagtcagctg gatttttcct tgaaacccac atggttcaag
    14701 gggaatggaa tgcctgtgtc tttaagaaaa ccaaggatat ttctggtgtg attggaggct
    14761 agcatgcagc agtattttgt aaaaggcagt gctatctctc ctgtcactat cgaggacaag
    14821 gaaaccagta agcatatgtt tcaggttatg cgcttgaaag aagaggatga ggttacctta
    14881 gtctttgatg atggcatcaa gcgcttggcg cgcgtgctgg atatggaaaa tcgtcagttt
    14941 gagttggtcc aagaattaaa tgacaatgtg gaactaccag ttcaagtgac catcgcatct
    15001 ggatttccca agggagacaa gctggagttc atcgctcaaa aagtaaccga actgggtgct
    15061 agccaaatct gggcctttcc tgcagactgg tcagttgcca agtgggatgg caagaaattg
    15121 ggtaaaaaag ttgaaaaact agaaaaaatt gcccttggag cagccgagca aagcaagcgt
    15181 aatattgtac caagtattaa acttttcgag aaaaaagcag attttctaac tcagctggac
    15241 cagtttgact ctatcatagt agcctatgaa gaatcagcta aagaaggaga agccgctgcg
    15301 cttctgcaag cagtcactgg tcttgaaaca ggagccaaac tgctctttat ctttggtcca
    15361 gaaggcggtc tctcacctgc agaaatcgaa agttttgaag ctaagggagc cgttttggta
    15421 ggcctaggtc ctcgtatttt gcgagcagaa acagcaccgc tttacgcctt atcagccctt
    15481 agtgttttag tagaattaga gaaataagag gaagaaaatg gaacaaaaac accgttcaga
    15541 atttccagag aaggaacttt gggatttaac agctctatac caagaccgtg aggatttctt
    15601 gcgtgcaatc gagaaagctc gcgaagacat caaccagttt agccgtgatt acaagggcaa
    15661 tcttcacact tttgaggatt tcgagaaggc ctttgcggaa ttggaacaga tctacattca
    15721 gatgagccat attggcaact atgcttttat gcctcagacg acggactata gcaatgacga
    15781 atttgcaaat attgctcaag ctgggatgga atttgaaaca gatgccagcg tagccttgac
    15841 cttctttgac gatgccttgg tggtagcaga cgaggaagtc ttggaccgtt tgggtgaatt
    15901 gcctcacttg acggcagcta ttcgtcaggc caaaatcaaa aaagcccact atctaggggc
    15961 tgatgtggag aaggccttga ccaatctcgg tgaagttttc tatagtccgc aggacattta
    16021 tactaagatg cgagctgggg attttgaaat ggctgacttt gaagcccatg gcaagaccta
    16081 taaaaacagc tttgtcacct atgagaattt ctaccaaaat cacgaggatg ctgaggttcg
    16141 tgagaaatcc ttccgttcct tctcagaggg acttcgtaag caccaaaata cggctgcagc
    16201 agcctatctg gctcaggtca agtctgaaaa actcttggct gatatgaagg gatacgactc
    16261 tgtctttgat tatcttctag ctgaacaaga agtggaccgt gtcatgtttg accgccagat
    16321 taacctcatc atgaaggact ttgcaccagt cgctcagaga tacctcaagc atgttgccaa
    16381 ggtaaatggt cttgaaaaga tgacctttgc agactggaaa ttggacttgg acagcgccct
    16441 caatcctgaa gtgactattg acgatgccta tgatttggtc atgaagtcgg tagaaccttt
    16501 ggggcaagaa tattgtcagg aagttgctcg ttaccaagaa gagcgctggg tggactttgc
    16561 tgctaacagt ggcaaggatt ccggtggtta tgcggcggac ccatatcgcg tacaccctta
    16621 tgtactcatg agctggacag gccgtttgag cgatgtctat accttgattc atgaaatcgg
    16681 gcattctggt caattcatct tttcagacaa tcaccaaagc tatttcaacg cccacatgtc
    16741 gacctattat gttgaagcac cgtcgacctt caatgaattg ctactcagtg attacttaga
    16801 gaaccagtct aatgacccac gtcaaaaacg cttcgctctg gctcatcgct tgacagacac
    16861 ctacttccat aatttcatca cccacctctt ggaagccgcc ttccagcgta aggtgtatac
    16921 attgattgaa gaaggagaaa ccttcggagc aagcaaactc aacagcatta tgaaggaagt
    16981 tttgacagat ttttggggcg atgccattga aatcgacgac gatgcagctt tgacttggat
    17041 gcgccaagct cactactata tgggcttgta tagttacact tactctgctg gtcttgtcat
    17101 ctcgacagct ggttaccttc atcttaaaaa ctcagaaact ggagctgaag actggctcaa
    17161 tctcctcaaa tcaggtggta gcaagacacc acttgagtca gccatgatta tcggtgctga
    17221 tatttcaaca gacaaaccac tccgtgatac catccaattc ttgtctgaca cagttgacca
    17281 gattatcgcc tacagtgctg agttggggga gtaaggggat agagaggttg ttatagaatg
    17341 ggtatggaca gttatttgct taaaagtcca tgtttaaatc ccccattcct tttcgaggaa
    17401 ttctttgccc ttctctgtaa tggtaagtga acgtggcgtt tgtgcaggga tgaccaattg
    17461 tttttcactg aaaaattcta aaagagcatt gccgagagct ccgccgacat gatttttacg
    17521 ttcgctccaa tccaaacatt tagggcaaaa tttccgtttt ttctttttca attcatccgt
    17581 atcaatgtgt aattttcttt ggaaataaga cttcccagct tcagtgagtt ggaagtcttt
    17641 ttctgattcg ctgaggagat tttcttgcaa gagataattg gtaatggaaa tgccaagctc
    17701 accagcaata tggtcatagc aggtgcgagc gacctttaat tcctttttgt gaatgtgttg
    17761 tttataactt ttgacatcac gctgaggaga gtagaagctg agaaattcca gcatttctgc
    17821 aatggcagca ctttttaaag aataataatg aaaacgtcca taggtttgta gagtggttac
    17881 ctgcgcttcg gtaagtaatt tgaggtgata gctgacagta tgttgcttga ttttggtaaa
    17941 gctggcaatt tcgttaaccg tgtgagcttt tccatccatt agaatatcta aaatgtgcat
    18001 ccgagaaggg tctgataaga gttttgtgat gatgaaaata tctggttcca taaaaatttt
    18061 ctccaaattt catatatcga tgattttcta tcttttatta tactataatt aaagcacaag
    18121 aaaaatagat tttaaaaatg ttttactaga gaatatttta aattttattg tctgagttta
    18181 aatggaggta aaattacaaa agtaattgca gcagtatcca cagttgaagg acgttaatct
    18241 taagattaca ttctcaacat tttttcaaaa gtgagatgaa ttaacaaagt atccaacatg
    18301 ctctatttgt gggggaaaga aagagtgaag aagttaagtg ttaaaaatct aaaaaagcaa
    18361 tatggttctt atgaagctgt caagggaatt agctttgaat tgggagacgg agagtgtttg
    18421 ggtatcttgg gaatcaacgg tgctggcaaa acatccactt taaagatgat ttactcactg
    18481 acctcaattt cctcaggaga gattgatatc ttggggcaaa atattgaaac caatcgtcgt
    18541 aagagtaaat cttgtctggg tattgtaggg caggaggata tgctggacat gaccttgaat
    18601 gtttatgata atctttttgc tcacggtcta tgttatggta tctcatctgt cgaacttagg
    18661 aagagaatcg attctctctt ggattttgtt caactgagca aacatgcgca aaagatggtg
    18721 aatcagctgt cgggtgggat gcgacgacgt cttgtcttgg caagagctct catcaatcgg
    18781 cctgatatta tcattttaga tgaaccgaca gttggtttag acattcaatc ccgcaatatt
    18841 atttgggata aacttttgga attgaaggaa ttaggtgttt ctatcattat tacttcccac
    18901 tatatgaatg agattgaata tttgacagat agggtgctga tgctccacca agggactatc
    18961 aaagaagaag gaactgtaga agacttgctc atcaagtatg atgctgacaa ccttgagacg
    19021 cttttttggg ggttgactgg gacagagaag gaggacttgc atgtttaagt tatcatttca
    19081 ctccatcgga cacgttgtgg tacgcaacta catgagtttt agaaatttat ttaaaatttc
    19141 aattgtcccc aaccttatcg accccctctt ttatctttta gcaatgggat ttggagttgg
    19201 tgcttatttg acgcatgtta acggtatgct ctaccgtgat tttgtcatta caggtttaat
    19261 tgctgcgact gccatgtctg cggccaccgc agaaacaacg gtcaatgcct ttatccagta
    19321 taagattgaa aagacttatg atgctatgtt gatgacgcca atcaatacga atgatattgt
    19381 ggtaggtcag gctatctggg caggtattcg tgcagtgatt ttcggtggga ttttttggct
    19441 gatttccatg cttatcacag cgcattttca tgtcttgatg ttattgattc ctctgatttt
    19501 atttatagtg ggttatttgt ttggtgtttt gggactaatc tttacctact tggcgccgtc
    19561 tagggaattt ctgaattact acaatgtttt ggtaatccgt cctctttata tgttttcaga
    19621 taccttcttt cccattactt ccttgccccc aatacttggt gatttgactt ggttttctcc
    19681 cttgtatcac gctacccgca tgattcgtat tatatgggga ggtgaggtga caggtttgta
    19741 tcttcatctt atctggttga tagccttggc gctcttgata acggtgcttc ctatgtatat
    19801 gttacatcgt agatattata gatagtctaa ttatttgtga tgttgtagtc atattctaat
    19861 ttatactaaa cgttattcga atttggacag gtatgggaac tgtgcctatc aatattgtaa
    19921 tttatggaag ttgaaatagt acggttcagt ttttaaatat tgttagaaat tgttttaaat
    19981 tccctaatca atttgtatag tttttatttc actttattat aactagtttt tcgcaatttt
    20041 tgagacagga atgtga
//
LOCUS       DAVLHC010000034        19424 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.034, whole genome shotgun sequence.
ACCESSION   DAVLHC010000034 DAVLHC010000000
VERSION     DAVLHC010000034.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 19424)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19424)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19424
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.034"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            86..439
                     /locus_tag="VXE25_001475"
     CDS             86..439
                     /locus_tag="VXE25_001475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000493111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEV0771919.1"
                     /translation="MFSTLEKIKELAKKRGIPLTKLEESLGYSTNYFYTLKTKTPNSE
                     RLQQIADYFNVSTDYLLGRTDNPAIAGDDTISGYTSDDLRKMAENAKTFDGKPLTEED
                     IDAIQNIIEIYLRGR"
     gene            441..1535
                     /locus_tag="VXE25_001476"
     CDS             441..1535
                     /locus_tag="VXE25_001476"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000156313.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771920.1"
                     /translation="MTITEQDALLFNTLFENIYHQLPSVDSSKDYWFVRAQKGQFYKS
                     FQTGGYIAIGWNYITLDDLKNLDEDAIKGKIKEFDSRIEKPGSAYNQMMKFAYSLKIG
                     DIVIVPSESPNDFLVGEITSRPYTESESNIESASNVCPFNKRMNVHWFGVIPNRDIDP
                     KLYKLVYSGHTITDANAYKKFINRGLYDAYIDHDHMSITFKVQEENNIDAFEYSTFLH
                     TVLQMVNVVKESDELKDEKVVLRTNVQSKGPIELLGHPEILIPVLVFIIILTGGIAFR
                     NLIKRNGANFEVDSKLGKFKAQLNSDGDEAIKKAQANKINAEAIALLIDKGMSPQFKG
                     ATSQLDIKAPEVATRILQDELLESPEKVEE"
     gene            1758..2138
                     /locus_tag="VXE25_001477"
     CDS             1758..2138
                     /locus_tag="VXE25_001477"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000151193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ImmA/IrrE family metallo-endopeptidase"
                     /protein_id="HEV0771921.1"
                     /translation="MTIEELVDSHGVTLAYFDNELWQRPGVYIKEISIIFINRELSED
                     AKKRVIYHELGHLEHSTALYQNNHTRCENEANRHMIHKLLEEELALSDDHQSFNYIQF
                     MQKHKLRTVTDELMVIDEYYELIG"
     gene            2280..3407
                     /locus_tag="VXE25_001478"
     CDS             2280..3407
                     /locus_tag="VXE25_001478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000266845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HEV0771922.1"
                     /translation="MWMEELPNGKYKFFERYKDPYTEKLKKVSVTMEKKTPQARNQAA
                     ILLQEKINKKLSTKQVESITFEEIYNLFYKSWAQTVKESTKHNCKSVDKKMKEVIPSD
                     TILANLDRRFLQEAIEKIIESNGYITAKKVRHRLRGIFNYAVQYSYIENNEVDYTTIP
                     QKPKTLEELEKKRNNFLTMQEIKALVDVLNRREYHQKYADMVLVLTLTGMRYGELTAL
                     QLKNIDFENNKIEITGNFDSVNKIKTLPKTTNSIRTIKVSESVIEAIQRQIVRLSERF
                     QPLSSDDYIFCFEKWNQPTTIACFIQILKKYGKQAKIEKNLSSHIFRHSHISFLAESG
                     LPIKSIMDRVGHSNAKMTLEIYSHTTEDMEDKLVNKLDTIF"
     gene            complement(3495..4406)
                     /gene="whiA"
                     /locus_tag="VXE25_001479"
     CDS             complement(3495..4406)
                     /gene="whiA"
                     /locus_tag="VXE25_001479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004257845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein WhiA"
                     /protein_id="HEV0771923.1"
                     /translation="MSFTVAVKEEILGQHHLSWHELSAIIKMSGSIGLSTSGLTLSVV
                     TENAKLARHLYESFLHFYEIKSEIRHHQRSNLRKNRVYTVFTDEKVQDLLSDLHLADS
                     FFGLETGIDEAILSDEEAGRAYLCGAFLANGSIRDPESGKYQLEISSVYLDHAQGIAS
                     LLQQFLLDAKVLERKKGAVTYLQRAEDIMDFLIVIGAMQARDDFERVKILRETRNDLN
                     RANNAETANIARTVSASMKTINNISKIKDIMGLENLPVDLQEVAQLRIQHPDYSIQQL
                     ADSLSTPLTKSGVNHRLRKINKIADEL"
     gene            complement(4403..5380)
                     /locus_tag="VXE25_001480"
     CDS             complement(4403..5380)
                     /locus_tag="VXE25_001480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YvcK family protein"
                     /protein_id="HEV0771924.1"
                     /translation="MRKPKITVIGGGTGIPVILKSLREKDVEIAAIVTVADDGGSSGE
                     LRKNMQQLTPPGDLRNVLVAMSDMPKFYEKVFQYRFSEDAGAFAGHPLGNLIIAGLSE
                     MQGSTYNAMQLLSKFFHTTGKIYPSSDHPLTLHAVFQDGTEVAGESHIVDHRGIIDNV
                     YVTNALNDDTPLASRRVVQTILESDMIVLGPGSLFTSILPNIVIKEIGRALLETKAEI
                     AYVCNIMTQRGETEHFTDSDHVEVLHRHLGRPFIDTVLVNIEKVPQEYMNSNRFDEYL
                     VQVEHDFVGLCKQVSRVISSNFLRLENGGAFHDGDLIVDELMRIIQVKK"
     gene            complement(5377..6267)
                     /gene="rapZ"
                     /locus_tag="VXE25_001481"
     CDS             complement(5377..6267)
                     /gene="rapZ"
                     /locus_tag="VXE25_001481"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNase adapter RapZ"
                     /protein_id="HEV0771925.1"
                     /translation="MTKKQLHLVIVTGMSGAGKTVAIQSFEDLGYFTIDNMPPALLPK
                     FLQLVEIKEDNPKLALVVDMRSRSFFSEIQAVLDELENQDGLDFKILFLDAADKELVA
                     RYKETRRSHPLAADGRILDGIKLERELLAPLKNMSQNVVDTTELTPRELRKTLAEQFS
                     DQEQAQSFRIEVMSFGFKYGIPIDADLVFDVRFLPNPYYLPELRNQTGVDEPVYDYVM
                     NHPESEDFYQHLLALIEPILPSYQKEGKSVLTIAMGCTGGQHRSVAFAKRLVQDLSKN
                     WSVNEGHRDKDRRKETVNRS"
     gene            complement(6319..6699)
                     /locus_tag="VXE25_001482"
     CDS             complement(6319..6699)
                     /locus_tag="VXE25_001482"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RidA family protein"
                     /protein_id="HEV0771926.1"
                     /translation="MAKTIHTDKAPKAIGPYVQGKIVGNLLFASGQVPLSPETGEIVG
                     ENIQEQTEQVLKNIGAILAEAGTDFDHVVKTTCFLSDMNDFVPFNEVYQTAFKEEFPA
                     RSAVEVARLPRDVKVEIEVIAEIG"
     gene            complement(6710..7297)
                     /locus_tag="VXE25_001483"
     CDS             complement(6710..7297)
                     /locus_tag="VXE25_001483"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002915299.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YihA family ribosome biogenesis GTP-binding
                     protein"
                     /protein_id="HEV0771927.1"
                     /translation="MELNTHNAEILLSAANKSHYPQDELPEIALAGRSNVGKSSFINT
                     MLNRKNLARTSGKPGKTQLLNFFNIDDKMRFVDVPGYGYARVSKKEREKWGCMIEEYL
                     TTRENLRAVVSLVDLRHDPSADDVQMYEFLKYYEIPVIIVATKADKIPRGKWNKHESA
                     IKKKLNFDPSDDFILFSSVSKAGMDEAWDAILEKL"
     gene            complement(7306..8538)
                     /gene="clpX"
                     /locus_tag="VXE25_001484"
     CDS             complement(7306..8538)
                     /gene="clpX"
                     /locus_tag="VXE25_001484"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002874765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit
                     ClpX"
                     /protein_id="HEV0771928.1"
                     /translation="MSTNRKNDMMVYCSFCGKNQEEVQKIIAGNNAFICNECVELAQE
                     IIREELVEEVLADLSEVPKPIELLHILNHYVIGQDRAKRALAVAVYNHYKRINFHDTR
                     EESEDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATALTEAGYVGEDVEN
                     ILLKLLQVADFNIERAERGIIYVDEIDKIAKKSENVSITRDVSGEGVQQALLKIIEGT
                     VASVPPQGGRKHPQQEMIQVDTKNILFIVGGAFDGIEEIVKQRLGEKVIGFGQNNKAI
                     DENSSYMQEIIAEDIQKFGIIPELIGRLPVFAALEQLTVDDLVRILKEPRNALVKQYQ
                     TLLSYDDVELEFDDEALQEIANKAIERKTGARGLRSIIEETMLDVMFEVPSQENVKLV
                     RITKETVDGTDKPILETA"
     gene            complement(8570..8740)
                     /locus_tag="VXE25_001485"
     CDS             complement(8570..8740)
                     /locus_tag="VXE25_001485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000442275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771929.1"
                     /translation="MERSLFGLFTAFLCFICFLAGAQAFRKKRYGLSILLWLNAFTNL
                     VNSIHAFYMTLF"
     gene            complement(8740..9246)
                     /locus_tag="VXE25_001486"
     CDS             complement(8740..9246)
                     /locus_tag="VXE25_001486"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000162460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrofolate reductase"
                     /protein_id="HEV0771930.1"
                     /translation="MTKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAIL
                     MGRVTFDGMGRRLLPKRETLILTRNPEEKIDGVATFQDVQSVLDWYQAQEKNLYIIGG
                     KQIFQAFGPYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTI
                     QYRKRKEV"
     gene            complement(9376..9894)
                     /locus_tag="VXE25_001487"
     CDS             complement(9376..9894)
                     /locus_tag="VXE25_001487"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000229877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA starvation/stationary phase protection
                     protein"
                     /protein_id="HEV0771931.1"
                     /translation="MVELKKEAVKDVTSLTKAAPVALAKTKEVLNQAVADLYVAHVAL
                     HQVHWYMHGRGFLVWHPKMDEYMEALDGQLDEISERLITLGGSPFSTLTEFLQNSEIE
                     EEAGEYRNVEESLERVLVIYRYLSELFQKGLDVTDEEGDDVTNGIFAGAKTETDKTIW
                     MLAAELGQAPGL"
     gene            complement(10391..11896)
                     /gene="lytC"
                     /locus_tag="VXE25_001488"
     CDS             complement(10391..11896)
                     /gene="lytC"
                     /locus_tag="VXE25_001488"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_078138769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline binding-anchored murein hydrolase LytC"
                     /protein_id="HEV0771932.1"
                     /translation="MSVTFFIGEERLKIKIGLASICLLGLATSHVAANETEVAKTSQD
                     TTTASSSSEQNQSSNKTQTSTEVQTNAAAHWDGDYYVKDDGSKAQSEWIFDNYYKAWF
                     YINSDGRYSQNEWHGNYYLKSGGYMAQNEWIYDSNYKSWFYLKSDGAYAHQEWQLIGN
                     KWYYFKKWGYMAKSQWQGSYFLNGQGAMMQNEWLYDPAYSAYFYLKSDGTYANQEWQK
                     VGGKWYYFKKWGYMARNEWQGNYYLTGSGAMATDEVIMDGTRYIFAASGELKEKKDLN
                     VGWVHRDGKRYFFNNREEQVGTEHAKKIIDISEHNGRINDWKKVIDENEVDGVIVRLG
                     YSGKEDKELAHNIKELNRLGIPYGVYLYTYAENETDAENDAKQTIELIKKYNMNLSYP
                     IYYDVENWEYVNKSKRAPSDTDTWVKIINKYMDTMKQAGYQNVYVYSYRSLLQTRLKH
                     PDILKHVNWVAAYTNALEWENPYYSGEKGWQYTSSEYMKGIQGRVDVSVWY"
     gene            complement(11934..12692)
                     /locus_tag="VXE25_001489"
     CDS             complement(11934..12692)
                     /locus_tag="VXE25_001489"
                     /EC_number="5.3.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000087908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="triose-phosphate isomerase"
                     /protein_id="HEV0771933.1"
                     /translation="MSRKPFIAGNWKMNKNPEEAKAFVEAVASKLPSSDLVEAGIAAP
                     ALDLTTVLAVAKGSNLKVAAQNCYFENAGAFTGETSPQVLKEIGTDYVVIGHSERRDY
                     FHETDEDINKKAKAIFANGMLPIICCGESLETYEAGKAAEFVGAQVSAALAGLTAEQV
                     AASVIAYEPIWAIGTGKSASQDDAQKMCKVVRDVVAADFGQEVADKVRVQYGGSVKPE
                     NVASYMACPDVDGALVGGASLEAESFLALLDFVK"
     gene            complement(12790..13467)
                     /locus_tag="VXE25_001490"
     CDS             complement(12790..13467)
                     /locus_tag="VXE25_001490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DnaD domain-containing protein"
                     /protein_id="HEV0771934.1"
                     /translation="MTYLDAFKSGTLVLPSALLLHFKELFPSSDDFLVWQFFYLQNTT
                     GLEEMSPSQIAERIGKEISDVNQSISNLTERGLLQYRTIELNGEIELFFDASLALERL
                     DDLFGAVRSSSDQLTPQNQLKDLVETFQQELGRLLTPFEIEDLTKTLKEDGTSADLIK
                     EALREAVLNGKPNWKYIQAILRNWRHEGIKSVAQIEAKRAEREASNPQLTQVSADFRN
                     AMDLWKD"
     gene            complement(13476..14420)
                     /locus_tag="VXE25_001491"
     CDS             complement(13476..14420)
                     /locus_tag="VXE25_001491"
                     /EC_number="2.3.1.46"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001122710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine O-succinyltransferase"
                     /protein_id="HEV0771935.1"
                     /translation="MPIRIDKKLPAVEILRTENIFVMDDQRAAHQDIRPLKILILNLM
                     PQKMVTETQLLRHLANTPLQLDIDFLYMESHRSKTTRSEHMETFYKTFPEVKDEYFDG
                     MIITGAPVEHLPFEEVDYWEEFRQMLEWSKTHVYSTLHICWGAQAGLYLRYGVEKYQM
                     DSKLSGIYPQDTLKEGHLLFRGFDDSYVSPHSRHTEISKEEVLNKTNLEILSEGPQVG
                     VSILASRDLREIYSFGHLEYDRDTLAKEYFRDRDAGFDPHIPENYFKDDDVNQVPCLC
                     WSSSAALFFSNWVNHAVYQETPFDWRKIEDDASAYGYL"
     gene            complement(14602..15114)
                     /locus_tag="VXE25_001492"
     CDS             complement(14602..15114)
                     /locus_tag="VXE25_001492"
                     /EC_number="2.4.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001049318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenine phosphoribosyltransferase"
                     /protein_id="HEV0771936.1"
                     /translation="MNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYA
                     TDKKVDMIVGPEARGFIVGCPVAFELGIGFAPVRKPGKLPREVISADYEKEYGVDTLT
                     MHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGVMAGCAFLVELDELNGREKIG
                     DYDYKVLMHY"
     gene            complement(15201..15959)
                     /locus_tag="VXE25_001493"
     CDS             complement(15201..15959)
                     /locus_tag="VXE25_001493"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001848902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HEV0771937.1"
                     /translation="MSEAGHKFLAKLGKKRLRPGGKRATDWLIAEGGFSKEKRILEVA
                     CNRGTTAIELAQRFGCKITAVDMDAQALEVAKKFAGTAGVAHLISFERANAMKLPYQD
                     ASFDIVINEAMLTMQADQAKKKCVMEYLRVLKPGGLLLTHDVLLKEAKESIRQELSQA
                     IHVNVGPLTQDGWEQVMIESGYCDVKALTGEMTLMKLSGMIYDEGLLGTLKICVNACK
                     KENRKQFLTMYKMFAKNKQKLGFIAMASYKSSKR"
     gene            16167..16313
                     /locus_tag="VXE25_001494"
     CDS             16167..16313
                     /locus_tag="VXE25_001494"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771938.1"
                     /translation="MEIKEQTRKLAVSCSKYIFEVADKTDEISNHTYGKATLTWFEEI
                     FEEY"
     gene            complement(16460..17590)
                     /gene="ugpC"
                     /locus_tag="VXE25_001495"
     CDS             complement(16460..17590)
                     /gene="ugpC"
                     /locus_tag="VXE25_001495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003010064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sn-glycerol-3-phosphate ABC transporter
                     ATP-binding protein UgpC"
                     /protein_id="HEV0771939.1"
                     /translation="MVELNLKNIYKKYPNSEHYSVEDFNLNIKDKEFIVFVGPSGCGK
                     STTLRMIAGLEDITEGTASIDGVVVNDVAPKDRDIAMVFQNYALYPHMTVYDNMAFGL
                     KLRKYSKEDINKRVQEAAEILGLKEFLERKPADLSGGQRQRVAMGRAIVRDAKVFLMD
                     EPLSNLDAKLRVSMRAEIAKIHRRIGATTIYVTHDQTEAMTLADRIVIMSATKNPAGT
                     GTIGRVEQIGTPQEVYKNPVNKFVAGFIGSPAMNFITVKLVGSEIVSDGFRLKVPEGA
                     LKVLREKGYEGKELIFGIRPEDVNAEPAFLETFPDCVVKATISVSELLGSESHLYCQV
                     GKDEFVAKVDARDYLQTGATVELGFDLNKAHFFDVETEKTIY"
     gene            complement(17874..17959)
                     /locus_tag="VXE25_001496"
     tRNA            complement(17874..17959)
                     /locus_tag="VXE25_001496"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(17923..17925),aa:Leu,seq:aag)
     gene            complement(18041..18616)
                     /locus_tag="VXE25_001497"
     CDS             complement(18041..18616)
                     /locus_tag="VXE25_001497"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine hydrolase"
                     /protein_id="HEV0771940.1"
                     /translation="MTKALISIDYTEDFVADSGKLTAGAPAQAISDAISKVTRLAFER
                     GDYIFFTIDAHEENDCFHPESKLFPPHNLIGTSGRNLYGDLGIFYQEHGSDSRVFWMD
                     KRHYSAFSGTDLDIRLRERRVSTVILTGVLTDICVLHTAIDAYNLGYDIEIVKPAVAS
                     IWPENHQFALGHFKNTLGAKLVDENLNELSE"
     gene            complement(18616..19404)
                     /gene="codY"
                     /locus_tag="VXE25_001498"
     CDS             complement(18616..19404)
                     /gene="codY"
                     /locus_tag="VXE25_001498"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP-sensing pleiotropic transcriptional
                     regulator CodY"
                     /protein_id="HEV0771941.1"
                     /translation="MAHLLEKTRKITSILKRSEEQLQDELPYNAITRQLADIIHCNAC
                     IINSKGRLLGYFMRYKTNTDRVEQFFQTKIFPDDYVQGANMIYETEANLPVEHDMSIF
                     PVESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLLN
                     FQREEDEKNIRRRTAVTMAVNTLSYSELRAVSAILGELNGNEGKLTASVIADRIGITR
                     SVIVNALRKLESAGIIESRSLGMKGTYLKVLISDIFEEVKKRDY"
BASE COUNT         5908 a         4260 c         3462 g         5794 t
ORIGIN      
        1 atactttttt ctagattgtg tcaatacttt tttctagaat tttagaaata ttttttgtga
       61 tacccttaga aaggttgatt taacaatgtt ttcaacgcta gaaaaaatta aagaattagc
      121 taaaaaaaga gggattcctc taacaaaact agaagaaagt ctaggatata gtaccaatta
      181 tttctatact ttaaaaacga aaaccccaaa ctctgaaaga ttgcaacaga tcgctgacta
      241 cttcaacgta tctacagact acttacttgg tcgtactgat aatcctgcta ttgctggtga
      301 tgatacaatc tcaggataca cgtctgacga cctccgaaag atggcagaga atgccaaaac
      361 cttcgatggt aagccactta cagaagagga tatcgatgcg attcaaaaca tcatagaaat
      421 atacttgaga ggtagatagt atgacgatta ccgaacaaga tgccttgctt ttcaataccc
      481 tttttgaaaa catatatcat caactcccgt ctgttgatag ttctaaagat tattggtttg
      541 taagggctca aaaagggcaa ttctataaaa gttttcaaac tggtggctat atcgccattg
      601 gatggaacta tataacatta gatgacctta aaaatcttga cgaagatgca atcaaaggaa
      661 aaatcaagga gtttgacagt aggatagaaa agcctggttc tgcctacaat caaatgatga
      721 agtttgcgta tagtcttaaa atcggagaca ttgtcattgt tccgtcagaa tctcctaacg
      781 attttcttgt aggtgaaata acgagcagac cctatacaga gagtgaaagc aacatagagt
      841 ccgcatctaa cgtttgccca tttaataagc gaatgaatgt gcactggttt ggagtcatac
      901 caaacagaga tattgacccg aaactttaca aattagtcta ttcaggccat accatcactg
      961 atgcaaatgc ctacaaaaaa ttcatcaacc gaggtctata tgatgcctac atcgatcatg
     1021 accacatgag tatcactttc aaagtacaag aggaaaacaa tattgatgct tttgaatact
     1081 caacatttct gcacactgtc ttgcaaatgg tcaatgttgt aaaagaatct gatgaattaa
     1141 aagatgagaa agtcgttcta agaaccaacg tccaatcgaa agggccgatt gaactacttg
     1201 gacatcctga aatactaatc ccggttctag tatttatcat tattctaact ggaggaattg
     1261 cttttcgcaa tttaattaaa cgcaatggtg caaactttga agttgattct aagcttggga
     1321 aatttaaagc tcagttaaat agcgatgggg atgaagcaat caaaaaagcc caggcaaata
     1381 aaataaatgc cgaggctatt gcattgttaa tagataaagg gatgagtccg cagtttaaag
     1441 gcgctacatc tcaactagat attaaagctc cagaagtagc aactaggatt cttcaagatg
     1501 aactactcga atctccagaa aaagtcgaag aataatttca gaaataacga aactgagtaa
     1561 aacgatgatt ggaagtgtta ggatttgtct tagaaaaaag taacaaatca aaaaaacaaa
     1621 tgctgaaact tgaaacagta cagctaaatg tgcatagagt ttcaacttca ttttaatcac
     1681 ttcctttcaa ttctatttta ctctagttca agagataaaa caactaattt taaaaaatat
     1741 ttgaaggatg atagcctatg actattgaag agctagttga ctcacacggt gtcactctcg
     1801 cttactttga taacgaactt tggcaaagac ctggagttta tatcaaagaa atcagtatta
     1861 tctttataaa ccgtgaactg tccgaagatg caaaaaaacg ggtcatatac cacgaattag
     1921 gacatctgga acattctact gcactatatc aaaacaacca cactaggtgc gagaatgagg
     1981 ctaataggca catgattcat aagttgctag aagaagaact tgcactatca gacgaccatc
     2041 aatctttcaa ctatatccag ttcatgcaaa aacataagct tagaacagtc acagacgaat
     2101 tgatggtaat tgacgaatat tatgaattga taggatagtt catcagaata actataaaaa
     2161 caaaaaatcc tcacactcgc catcgccaaa ctttgagtgt gaggatatcc agtatagtaa
     2221 aaggcattaa aaagcccttt ttactatacc cattttaaca aaaaagtgag gtaaacgcaa
     2281 tgtggatgga agaattgcca aacggcaaat ataaattttt tgagcgatat aaagatccat
     2341 atactgagaa attaaaaaaa gtttcagtaa ccatggagaa gaaaactccc caggcaagaa
     2401 atcaagctgc tatcttgtta caagagaaga taaataaaaa actcagcaca aaacaagtag
     2461 aaagcattac atttgaagaa atctataacc ttttctataa atcatgggcg caaacagtaa
     2521 aggaatcaac aaaacataat tgtaaatcag ttgataagaa gatgaaagaa gtcataccat
     2581 ccgataccat acttgctaat cttgacaggc gttttcttca agaggctatt gaaaaaatta
     2641 ttgaaagcaa cggatatatt acagctaaaa aagtacggca taggctcaga ggtatcttta
     2701 attacgctgt tcaatactct tacattgaaa acaacgaggt cgattatact acgattcctc
     2761 aaaaaccaaa gactttagaa gaactggaaa aaaagcgtaa caactttctc accatgcaag
     2821 aaataaaagc acttgtcgat gtccttaatc gtcgagaata tcaccaaaag tacgctgata
     2881 tggttcttgt gctgacatta acgggtatga gatatggtga gttaactgcc ttacaactga
     2941 agaatataga cttcgaaaac aacaaaattg agatcacagg taattttgat tcagtaaaca
     3001 aaatcaagac gctaccaaag actacaaatt caatacggac aatcaaagta tcagagagtg
     3061 tcatagaagc tattcaaaga caaatagtac gacttagcga acgtttccag ccattgtcaa
     3121 gcgatgatta tattttctgt tttgaaaaat ggaatcaacc tacaacaata gcttgcttca
     3181 tacagatatt aaaaaaatat ggaaaacagg ccaaaataga aaaaaattta tctagccata
     3241 tttttaggca ttctcatatt tcgtttttag cagagtctgg cctcccaata aaatcaataa
     3301 tggatcgagt tgggcactca aatgcaaaaa tgactttgga aatctattct catactactg
     3361 aagatatgga ggataaactg gtcaataaat tagatactat tttttaattc tgccccttgg
     3421 ttgccccttt ttgatttcat aacacaacaa aaccccttga agatattgat aattcaaggg
     3481 gttgctttat atcgttataa ttcatccgct atcttattga tttttctgag tctgtgattg
     3541 acaccacttt tggtcagagg ggtgctgagg ctatctgcca actgttggat agagtagtct
     3601 gggtgctgaa tcctcagttg cgccacttcc tgcaaatcta ctggcaaatt ttctaagccc
     3661 atgatatctt ttattttact gatattgtta atggtcttca tgctggcaga aactgtccga
     3721 gcgatattag ctgtctcggc attattagcc cgattgaggt cgttacgggt ttctcgcaaa
     3781 atcttaaccc gctcaaaatc atcacgtgcc tgcatggctc cgattactat caagaagtcc
     3841 ataatgtctt ctgctcgctg gagataggtc acagccccct tcttgcgctc aagcaccttg
     3901 gcatccagta aaaactgttg gagaagggag gcaattcctt gcgcgtggtc cagataaaca
     3961 gaactgattt ccaactggta cttgcctgac tcagggtcac gaatgctccc atttgccaag
     4021 aaagcgccac agagataggc acgacctgct tcctcatccg ataaaatcgc ctcatcaata
     4081 cctgtttcta ggccaaagaa agagtctgcc aagtgcaaat cacttaacaa atcctgcacc
     4141 ttttcatctg taaaaacggt atagacgcga ttcttgcgaa gattgctccg ttggtggtga
     4201 cgaatttcag atttgatttc atagaaatgg agaaaggact catagaggtg acgggccagt
     4261 ttggcatttt ctgtcacaac tgacaaagtc aagcccgaag tcgagagacc gatgctacca
     4321 gacattttga taatggcaga taattcatgc cagctcagat ggtgttggcc caggatttct
     4381 tcttttactg ctactgtgaa actcattttt tcacctgtat aatgcgcatc aactcgtcca
     4441 caatcaaatc tccatcgtgg aaggcaccgc cattttccag acgaaggaag ttagatgaaa
     4501 tcacgcgcga aacttgctta caaagaccta caaaatcgtg ttccacttgc accaagtatt
     4561 catcaaaacg gttggaattc atgtattcct gaggcacttt ttcaatattc accaagacag
     4621 tgtcgataaa agggcgacca aggtgacgat gcaagacttc cacgtggtcg ctatctgtaa
     4681 agtgttccgt ctccccacgt tgggtcatga tattgcagac ataggcaatt tctgccttgg
     4741 tttccaaaag agcccgccca atttccttaa tcacgatatt gggcaaaata gaggtaaaga
     4801 gagaacctgg ccctaggaca atcatgtcac tttcaaggat ggtctgcact actcgacggc
     4861 tggccagagg cgtatcatcg tttagggcat tggtcacata gacattgtca attatgcctc
     4921 gatggtctac aatatgactc tctccagcca cttctgtccc atcctgaaag actgcatgaa
     4981 gggtcaaagg atggtcactg gaaggataaa ttttccctgt tgtatggaaa aatttgctca
     5041 ataactgcat ggcattatag gttgaaccct gcatttctga caagccagca atgatgagat
     5101 ttcccaatgg atggccagca aaggctccgg catcctcaga gaaccgatac tgaaagacct
     5161 tctcataaaa cttaggcata tccgacatgg ccacaaggac attacgaaga tcacctggcg
     5221 gtgtcaactg ttgcatattt tttcggagtt cacctgaaga accaccatca tctgccaccg
     5281 tcacgatagc tgcgatttcc acatcttttt cccgcagact ttttagaatg acgggaattc
     5341 cagtccctcc accaatcacc gttatctttg gttttctcat gaacggttta ccgtttcctt
     5401 tctgcggtct ttgtcgcgat gcccttcatt aacagaccaa ttcttggata agtcctgcac
     5461 caagcgttta gcaaatgcca cactacggtg ttgtccaccc gtacatccca tggcaatggt
     5521 caaaacggac ttaccttcct tttggtaact tggcagaatc ggctcaatca aggccaataa
     5581 atgttgataa aagtcttctg actcaggatg gttcatgaca taatcataaa caggttcatc
     5641 cacacccgtt tggtttctca gttctggtag ataataggga tttggcaaga aacggacatc
     5701 aaagaccaag tccgcatcaa tcgggattcc atacttaaat ccgaaagaca tgacttcgat
     5761 acggaaagac tgggcttgtt cttggtctga aaactgctct gcaagggttt tgcgcagctc
     5821 acgtggagtg agttcagtcg tatccaccac attttggctc atatttttca aaggtgccaa
     5881 gagttcacgt tccaacttga ttccatctaa aatacgaccg tctgctgcta gtgggtgact
     5941 ccgtctggtc tccttgtaac gagcgaccaa ttccttatca gccgcatcca aaaagaggat
     6001 tttgaaatcc aaaccatctt gattttccaa ctcatccaaa acagcttgaa tctctgaaaa
     6061 gaaagaacgg ctacgcatat ccactaccaa ggccaactta ggattgtctt ccttaatttc
     6121 aaccagctgc aaaaacttag gcaagagagc tggcggcata ttatcaatgg tgaaataacc
     6181 tagatcctcg aaggactgaa tggctacagt tttccctgcg ccactcatcc ctgtcacaat
     6241 caccaagtga agttgtttct ttgtcatctt tttctcctta tatcaaaaga agtttggcaa
     6301 caccaaactt caactagctt atccaatctc tgcgatgact tcaatttcga cttttacatc
     6361 acgaggaaga cgagctacct ccacagctga acgagctggg aattcctctt tgaaggccgt
     6421 ttggtaaacc tcattaaaag gaacaaagtc gttcatatcg ctcaagaagc aagttgtttt
     6481 gacaacatgg tcaaagtctg ttcctgcttc tgccaaaata gcaccgatgt ttttcaagac
     6541 ttgctctgtc tgttcttgga tattctctcc tacaatttcc ccagtttcag gggatagggg
     6601 aacttgaccg ctagcaaaca aaaggttgcc aacgattttt ccttgaacat agggtccgat
     6661 agcctttggg gccttatctg tatgaattgt ttttgccatt ttcttttcct cacaattttt
     6721 ctaagattgc atcccaagcc tcatccatcc ctgccttgct gacagatgaa aagaggatga
     6781 aatcgtcact tgggtcaaag tttaatttct ttttgattgc tgattcatgc ttgttccatt
     6841 taccacgagg aatcttgtcc gccttggtcg ccacaatgat gactggaatc tcataatact
     6901 tgagaaattc gtacatctgc acatcatctg ctgacgggtc atgacgaagg tcaactagac
     6961 tgacaaccgc acggagattt tcccgagtcg ttaagtactc ctcaatcatg cacccccact
     7021 tttcacgttc ctttttagaa acacgagcat agccataacc aggcacatcc acaaagcgca
     7081 tcttgtcatc aatgttaaaa aagttcagga gctgggtttt accaggtttt cctgatgtac
     7141 gggcgagatt cttacggttc aacatagtgt tgataaagct ggatttacca acatttgaac
     7201 gccctgctag ggcaatctct ggcagttcat cctgcggata gtgggactta ttagctgcac
     7261 tgagcaagat ttcagcattg tgtgtattaa gttccatagt cacctctagg ctgtttctag
     7321 gatcggttta tccgttccat ctacagtttc tttagtgatg cgaaccaatt tcacattttc
     7381 ctgactcggc acctcaaaca tgacatctag catggtttct tcgatgatgg agcgaagtcc
     7441 acgcgcccct gtcttccgtt cgattgcttt attagcaatc tcttgaaggg cttcgtcgtc
     7501 aaattccaac tcaacatcat cataagaaag caaggtttgg tattgtttca ccaaggcatt
     7561 tcttggctct ttcaagatgc gaaccaagtc atcaacggtc aattgctcaa gagccgcaaa
     7621 aacaggcaag cgtccaatca actcagggat aataccaaat ttttgaatgt cttcagcgat
     7681 gatttcttgc atgtatgagc tgttttcgtc aatcgcctta ttgttttgac caaatccgat
     7741 aactttttca cccagacgtt gtttgacaat ttcttcaata ccatcaaaag caccacccac
     7801 gatgaagagg atattttttg tatccacttg aatcatctct tgttgtggat gtttgcgtcc
     7861 accttgaggc ggcacgctag caacagttcc ctcaataatc ttgagaaggg cttgttgcac
     7921 cccttcacca gaaacatcac gtgtgataga cacattctca ctcttcttgg caatcttgtc
     7981 aatttcatcc acatagataa tgccacgctc tgcacgttcg atgttaaagt cagcaacctg
     8041 caagagtttg aggaggatat tttccacgtc ctcacccaca taaccagcct ccgtcagagc
     8101 tgtcgcatcc gcaatagcaa aaggtacatt caagctctta gccaaggtct gggcaaggaa
     8161 agttttccct gaaccagttg ggccaatcat caaaatgttt gacttctgca aatctacatc
     8221 ttctgactct tcgcgtgtat cgtggaaatt gatgcgtttg tagtggttat aaaccgccac
     8281 tgccaaggca cgcttggcac gatcttgacc aattacatag tggttcaaga tatggaggag
     8341 ttcaattggt tttggcacct cagacaagtc tgccaagact tcctcaacca attcttctcg
     8401 aatgatttcc tgagctaact ccacgcattc attacaaata aaagcattgt tgccagcaat
     8461 tattttttgt acttcttctt ggtttttgcc acaaaatgag caataaacca tcatatcatt
     8521 ttttctattt gtagacatga tttccttcca ttctatactg tcattctatc taaaataagg
     8581 tcatgtaaaa agcatgaata ctattgacca gattggtaaa ggcatttaac caaaggagga
     8641 tagaaagccc gtaacgcttt ttacgaaaag cctgtgctcc tgccagaaag cagatgaaac
     8701 acagaaaagc cgtgaataga ccaaataaac tccgttccat tagacttcct ttctcttgcg
     8761 gtattggatg gtaaaatcat aaggattctt ctcatctttg gcgtaaaatt tgcttgaaac
     8821 tgtctcaaaa agagacaagt caagctcttc agggaaatag gtatctcctt ccacccgagc
     8881 atgaatgtga gtgacaatca cttcatcaag gtaaggtcca aaagcctgaa aaatttgctt
     8941 cccaccgata atgtagagat tcttttcttg agcctgatac cagtcaagaa cagactggac
     9001 gtcctgaaaa gtagcaaccc catctatctt ttcttccgga ttacgcgtca aaatcaaggt
     9061 ttcccgtttt ggaagcaagc gacgtcccat cccatcaaag gtcacacgcc ccatcaagat
     9121 agcatgattc agagttgttt ctttaaagtg ctgcaattct gctggcaaat gccaaggcag
     9181 acgattttcc ttaccaatca caccctcttc atcctgggcc caaatagcta cgattttctt
     9241 agtcatgctt ccatcctttt cactgatagt actattttat caaaaaactc aaaaaaagac
     9301 tggtttggaa tagcttacaa aatagaaaaa atctgtaaga aatttcctac agatttatct
     9361 atgtttcctt atttcttaca aaccaggtgc ttgtccaagt tcggctgcaa gcatccaaat
     9421 tgttttatct gtttcagttt tagcgcctgc aaagataccg tttgtcacat cgtcaccttc
     9481 ttcatcagtg acatccaaac ctttttggaa aagttctgac aagtaacggt agataacaag
     9541 aacacgttcc aagctttctt caacattacg gtattcacca gcttcttctt cgatttcact
     9601 attttgaagg aactctgtca atgtagagaa tgggcttcca ccgagtgtaa tcaagcgttc
     9661 gctgatttca tccaattgac cgtcaagagc ttccatgtac tcatccattt ttggatgcca
     9721 tacaaggaaa ccacgaccat gcatatacca gtgcacttgg tgcaaagcaa cgtgagctac
     9781 atacaaatca gcaacagctt ggttcaagac ttcctttgtt tttgccaatg ctactggcgc
     9841 tgcttttgtc aatgatgtta cgtcttttac tgcttctttt ttcaattcta ccattttctt
     9901 tacctcattc attatttttt gtaaccactt cttaatgatt actaccttag tatactacta
     9961 aggaaaacca atagcaagac aaagaactta tatgagaaaa gttgcaatag actgataatt
    10021 taagaattct ttagaagaca aaaaagaggg ttggatgctt atagtcaatg gaaatccatc
    10081 agcaaactag gaaactaaac ccagcttgac caaagcacaa gttttgaggt cgcaggtagg
    10141 actgaccaag ctgatgtggt ttgaagaaat tccccaatac tataatagat tgaaataaga
    10201 tgaaaccaag tcgattagga aaggtaaatg aatttctaaa atgttttacc aatcacaagg
    10261 tctttatcta tattcaatct actatataag cttcatttcc gagcaagatc ttgaatttac
    10321 tcgaggatga actatcataa aacaaagaaa aagagggtgc tactatcaca tccctctttc
    10381 aaatcatcgc ttaataccaa acgctgacat ctacgcgccc ttggattcct ttcatgtatt
    10441 cagaagaggt atattgccaa cctttttctc ctgaataata agggttttcc cattctaaag
    10501 cattcgtata ggccgctacc cagtttacat gttttaaaat atctgggtgt tttaaacgcg
    10561 tctgtaataa actacgatag ctatagacat acacattttg ataacccgcc tgcttcatcg
    10621 tgtccatgta cttgttgatg attttaaccc aagtgtctgt atcacttgga gctctcttgc
    10681 tcttatttac atattcccag ttctcaacat cataatagat agggtaagac aggttcatat
    10741 tgtatttctt tataagttca atggtctgtt tagcgtcatt ctcagcatcg gtctcatttt
    10801 cagcataggt atagagatag acaccataag gaattcccag acggtttaac tccttaatgt
    10861 tatgcgccaa ttccttgtct tctttaccgc tataacctag acgaacaatg acaccatcca
    10921 cctcgttctc atcaataacc tttttccaat cattgatacg accattgtgc tcactaatat
    10981 caatgatttt cttagcatgt tcggttccca cttgttcttc tctattatta aagaaatagc
    11041 gtttaccatc tctgtgaacc cagccgacat tcaaatcttt cttttctttg agctcaccag
    11101 aggccgcaaa gatatagcga gtaccatcca taatcacttc gtcagtcgcc atggcaccac
    11161 ttccagtcaa atagtagttg ccttgccact cattccgagc catatagccc cacttcttga
    11221 aatagtacca tttgccgccc actttttgcc actcttggtt agcataagtt ccatcggatt
    11281 ttagataaaa ataagcagaa taggctggat catagagcca ttcattttgc atcatagctc
    11341 cttgaccatt caagaaataa cttccttgcc attggctttt agccatgtaa ccccacttct
    11401 tgaagtagta ccacttattt ccaatcaatt gccattcttg atgagcataa gccccatctg
    11461 acttgagata aaaccaactc ttgtaattac tgtcatagat ccactcgttt tgggccatat
    11521 atccacctga tttcaggtag taatttccat gccattcatt ctgcgagtaa cgaccatctg
    11581 aattaatata aaaccaggcc ttatagtagt tgtcaaaaat ccattcactt tgagctttag
    11641 agccatcatc ctttacataa taatccccat cccagtgggc agcagcatta gtctgtactt
    11701 ctgtgctcgt ttgcgtttta ttagaagact gattttgctc tgaactactt gaagctgtcg
    11761 ttgtatcctg cgaagttttt gctacttcag tttcatttgc agcgacatga ctagttgcca
    11821 agcctagtaa acagatactt gctaatccaa tttttatttt caatctttcc tctcctataa
    11881 aaaatgtaac agacatctga atgctgttcc acctagcttt tgctacttac tgattatttt
    11941 acaaagtcaa gcaaagccaa gaagctttca gcttcaagtg acgcaccacc tacaagggca
    12001 ccgtcaacgt ctgggcaagc catgtatgaa gcaacatttt caggtttaac agaaccaccg
    12061 tattgaacac gaactttgtc tgcgacttct tgaccaaagt cagcagctac aacgtcacga
    12121 acaactttac acattttttg tgcatcgtct tgtgaagctg atttaccagt accgatagcc
    12181 cagattggct cataagcgat aactgaggca gcaacttgtt cagcagtcaa tccagccaat
    12241 gcagcagata cttgagcacc tacgaattca gcagctttac cagcttcgta agtttcaagt
    12301 gattcaccac aacagatgat tggaagcata ccgttcgcaa agattgcttt tgcttttttg
    12361 ttgatatctt cgtcagtttc atggaagtag tcacggcgtt ctgagtgacc gataacaacg
    12421 taatcagtac cgatttcttt caaaacttgt gggctagttt caccagtgaa agcacctgca
    12481 ttttcaaagt agcagttttg agcagcaact ttaaggttcg agccttttgc aacagcaaga
    12541 acagttgtca aatcaagagc tggagcagcg atacctgctt caacaagatc tgatgaagga
    12601 agttttgatg caactgcttc aacgaatgct ttagcttctt ctggattttt gttcattttc
    12661 cagttaccag cgataaatgg tttacgtgac atttcacata cctctttttt caatttattt
    12721 tctatttatt ctatcacaat tatacacagc ttgcaaatct tactcggatt tcaagcctac
    12781 ttgcatggat taatccttcc agagatccat ggcatttctg aaatctgcag atacctgtgt
    12841 caactgagga ttgcttgctt ctctttctgc tctcttggcc tcaatttgag ccacactctt
    12901 gattccttca tggcgccagt ttctcaaaat tgcctgaatg tacttccagt ttggttttcc
    12961 attcaaaaca gcttcacgaa gagcctcctt aatcaagtca gcactggttc catcttcctt
    13021 tagtgtcttg gtcaaatcct caatctcaaa aggcgtcaac aatcgtccca actcctgctg
    13081 gaaggtttcc accaaatcct tgagctggtt ttgaggtgtt agctggtctg aacttgaacg
    13141 aactgctcca aacaggtcat ccaaacgttc caaggccaaa ctagcatcaa agaacaattc
    13201 aatttcgcca tttaattcga tagtacgata ctggagcagt cccctttccg tcagattaga
    13261 aatggactgg ttgacatccg aaatttcctt gccaatcctt tcagcaatct ggcttggcga
    13321 catttcttct aagcctgtcg tattttgcaa atagaaaaat tgccaaacca gaaaatcgtc
    13381 gctagaagga aagagttcct taaaatgcaa gagcagggca ctcggtaaaa ccaaggtacc
    13441 tgatttaaaa gcgtctaaat atgtcataat tcctcttata aatacccata tgcagatgca
    13501 tcatcttcta tctttctcca atcaaaaggc gtctcctgat agaccgcatg gtttacccaa
    13561 ttactgaaaa agagggctgc agatgaagac caacaaagac aaggtacctg attaacatca
    13621 tcatctttaa agtaattttc tggaatatgt gggtcgaaac ctgcatcacg atctcgaaaa
    13681 tactcttttg ccaaggtatc acggtcatac tccaaatgac caaaactata aatttctcgt
    13741 aaatcacgac tggccaaaat agaaacccca acctgaggtc cttctgataa aatctcgaga
    13801 ttggtcttgt ttaagacctc ttccttagaa atctccgtgt gccgtgaatg aggggataca
    13861 tagctatcat caaagcctct aaatagaagg tgaccctctt ttagggtgtc ctgaggataa
    13921 atacctgata gcttactgtc catctggtat ttttctacac catagcgcag ataaagccca
    13981 gcctgagccc cccaacagat atgaagggtc gaatagacat gagtcttaga ccactcaagc
    14041 atctgtctaa attcctccca atagtccact tcctcaaatg gtaaatgctc aactggagca
    14101 cccgtgatga tcatcccatc aaaatactca tccttgactt caggaaaagt tttatagaag
    14161 gtctccatgt gctctgaacg agttgtttta gaacggtggc tctccatata gagaaaatca
    14221 atatccagtt gtaggggtgt attagccaag tggcgcaaca actgggtctc tgtgaccatt
    14281 ttctgtggca tgagatttaa aattaaaatc ttcaaaggac ggatatcttg gtgggcagca
    14341 cgttgatcat ccatgacaaa gatattctct gtccgtaaaa tctcaacagc tggcaatttt
    14401 ttatcaattc gaatcggcat aaccctctcc taactgtact ctttcaggaa taattgcata
    14461 tgtttgaaga caaatctcaa acacttagtc cttttattat actgcaagaa gatatagttt
    14521 tcaattatag tttttctcta actagttata gtctattttt atatcctagt gtagagaaaa
    14581 cagccctagg gactgttttc attaataatg cataagaact ttgtagtcgt agtcaccaat
    14641 tttttcacgg ccgttcaatt catccaattc aacaaggaag gcacaacctg ccataacacc
    14701 accaagtttt tcaatcatct cgatagttgc cttaacagtt ccacctgtcg ccaaaaggtc
    14761 atctacaata agaacacgtt gacctggctt aatggcatcc gcgtgcatag tcaaggtatc
    14821 gacaccgtac tctttttcat agtcagcaga aataacttcg cgtggcaatt tacctggctt
    14881 acgaacaggc gcaaaaccaa ttcccaactc aaaggcaact ggacaaccca cgataaatcc
    14941 acgagcttca ggtcccacga tcatgtcgac tttcttgtca gtagcatact gaacgatttc
    15001 acgaacagcg tagctataag catttccatc agccatcaaa ggactaatat cacggaaggt
    15061 aatgccttcc tttggataat tttcaattgt tgcaatgtaa tcttttaaat tcatcttttt
    15121 ctttctttca aagtttttta ctctctatta tagcatattt tttaagaaag aaaaaaggaa
    15181 aagttaactt caataattat ctaacgtttt gacgatttat aactagccat cgcaataaag
    15241 cccaatttct gtttattctt agcaaacatt ttatacatag ttaaaaactg ctttctattc
    15301 tcctttttac aagcatttac acaaattttc aaagttccta gcaaaccttc gtcataaatc
    15361 atacccgata atttcattaa tgtcatttca ccagtcaatg ctttcacatc acaataacct
    15421 gattctatca tcacctgttc ccaaccatct tgagttaaag gacctacatt tacatgaatt
    15481 gcttgtgata attcctgtct gatagactct ttagcttcct taagaagcac atcatgtgtc
    15541 aagagaagac ctccaggttt taataccctt agatattcca ttacacattt tttcttagct
    15601 tgatcggctt gcatagtcag catagcttca tttataacaa tatcaaaact agcatcttga
    15661 taaggaagtt tcattgcatt tgctctttca aaactgatta aatgagcaac acctgccgtt
    15721 ccagcaaatt ttttagccac ttctaaagct tgagcatcca tatcaacagc agttatcttg
    15781 caaccaaaac gctgtgccaa ctcaattgct gtagttcccc tattacacgc aacctctagt
    15841 attctctttt cttttgaaaa tcctccttct gcaattaacc aatctgtggc acgctttcca
    15901 cctggacgta agcgtttttt ccccaatttt gctaaaaact tatgacctgc ttctgacatt
    15961 tgaacacctc tgttttttct tcattataac acaaaatgat attatctgac aattctaatc
    16021 tattatttga taaactagaa tcaaaagcat acaagtcacc ataactatag cataaattta
    16081 ttattacctc tctagttcga attcaattgc tcacgtagtt tacgcatata gcttcacttg
    16141 tagatggtac ccacaaataa tactcaatgg aaatcaaaga gcaaactagg aaactagccg
    16201 taagctgctc aaagtacatc tttgaggttg cagataaaac tgacgaaatc agtaatcata
    16261 cgtacggcaa ggcgacgttg acgtggtttg aagagatttt cgaagagtat taaagagcat
    16321 cacaatatag atgcataata tgacttctct agcaaaaagg agagaagcat tttgtttctc
    16381 tccctagatt aactgatatc tctccactac aattgataaa gagatatctt ttcttgtagt
    16441 gctttgaatt ttatttattt tagtagattg ttttttcagt ttctacatcg aagaagtgtg
    16501 ctttgttcaa gtcaaatcca agctcaactg ttgcacctgt ttgcaagtag tcacgagcat
    16561 caacttttgc aacaaactcg tctttaccaa cttggcagta aaggtgagat tctgaaccaa
    16621 gcagttctga tacagagata gtcgctttta caacacagtc tgggaatgtt tcaaggaaag
    16681 caggttctgc attcacgtct tctggacgga taccaaagat caattctttt ccttcgtagc
    16741 ctttttcacg aagaactttc aatgctcctt ctggcacttt caaacggaaa ccgtcagaaa
    16801 caatttcgct accaaccaat ttcacggtga tgaagttcat agctgggctt ccgatgaatc
    16861 ctgcaacgaa tttgttaact ggatttttgt aaacttcttg aggagtaccg atttgttcta
    16921 cacgtccgat agtacctgta ccagcagggt tcttagtagc tgacataata acgatacggt
    16981 ctgcaagtgt catcgcttct gtttggtcgt gagttacata gatagttgta gctccgatac
    17041 gacggtgaat tttagcgatt tcagcacgca ttgatacacg aagtttggca tccaagtttg
    17101 acaaaggttc gtccatcaag aatactttcg catcacggac aatcgcacgc cccatggcaa
    17161 cacgttgacg ttgaccacct gaaaggtcag ctggtttacg ttccaagaat tctttcaatc
    17221 caagtatttc agctgcttct tgaacacgtt tgttaatgtc ttctttgctg tatttacgca
    17281 atttcaaacc gaaagccatg ttgtcataaa cagtcatgtg tgggtaaaga gcgtagtttt
    17341 ggaataccat ggcgatatca cggtcttttg gagctacgtc gttgacaact acgccatcga
    17401 tagatgcagt accttctgta atgtcttcaa gaccagcaat catacggagt gtagttgatt
    17461 taccacatcc tgaaggtcct acgaaaacga taaattcttt atctttgatg ttcaagttga
    17521 aatcttcaac tgaatagtgt tcgctgtttg gatatttttt gtaaatattt ttaagattca
    17581 attctaccat gaggtgaact ccttttgtct tttgataatt atattatata tgaaaacgct
    17641 ttatatttct atggcaagat gaccaaaaaa ataaacaagt tctgtgcaac ttgcacaaaa
    17701 ctttagagaa tatcggagaa tttgaagaag ataatcttta ttattcttct atagacaaaa
    17761 gcagaaacaa ggatcagttt tcccatattt tcgctgattc tccactacat ttgactggat
    17821 tctaattttt tagagaaata caaaagagct agctttagct agctcttttc ctatgcggag
    17881 agagggactt gaaccctcac gacctaaagc ggtcacagga tccttagtcc tgcgcgtctg
    17941 ccaattccgc catccccgcg tcgattactt tactagtata tcaacttttg ggatgcttgt
    18001 caacactttt tttcaaattt tttcattttc accaaccagg ttactcagaa agttcattta
    18061 gattttcatc tactaactta gctccgagtg tatttttgaa atgacctagg gcaaattgat
    18121 gattttcagg ccagatggaa gcaacagctg gtttaacaat ctcgatgtca tatcctagat
    18181 tataggcatc tatagctgta tgtaggacac agatatccgt caagacacct gttaagataa
    18241 cggtagacac tctacgctct ctcaaacgaa tatctaggtc agtccctgaa aaagctgagt
    18301 aatggcgttt atccatccaa aagacacgac tgtctgaacc atgctcttga taaaagatcc
    18361 ccaaatctcc atataaattc cgtccactcg tcccaatcag attatgagga ggaaataact
    18421 tactttccgg atggaaacaa tcgttttctt catgagcatc aatagtaaag aagatataat
    18481 ctcctcgttc aaaagctaat cgagttacct tgctgatggc atccgaaatc gcctgagctg
    18541 gagcacctgc tgttagtttc ccactatcag caacaaaatc ttctgtataa tcaatcgaaa
    18601 ttaaagcctt tgtcattagt aatctctttt cttcacttct tcaaaaatat ctgaaatcaa
    18661 gaccttaaga taggttccct tcattccaag tgagcgactt tcaataatcc ccgcagactc
    18721 aagtttacga agagcattga caatcacaga gcgagtgatt ccgatacgat ctgcaatcac
    18781 tgacgcagtc aacttccctt catttccatt taattcccct aaaattgctg aaacagcacg
    18841 gagttcggag taagaaaggg tattgaccgc catggtgaca gcagtacgac gacgaatatt
    18901 tttctcatct tcttcacgtt ggaagttaag aagctgaatc ccaacaacgg tactggcaat
    18961 ctcaacaaga accaagtcct catcttcgaa ttttttatca ttacgccaaa taatcaaaga
    19021 accaaggcga atccccgata catgaatcgg tgcaatagtc gtcaagccat ctggaaaatc
    19081 atctctactc tcaacaggga aaatactcat atcatgctca acaggtaagt ttgcttctgt
    19141 ttcgtaaatc atattagccc cttgaacgta gtcatctggg aaaatcttag tttggaagaa
    19201 ttgctctacg cgatctgtat ttgttttata acgcataaaa tagccaagca gacgtccctt
    19261 actattgata atgcaggcat tgcaatgaat aatatccgct aactgacgcg taatagcgtt
    19321 gtaaggaagc tcatcctgca actgctcctc tgagcgtttc aaaattgatg taatttttct
    19381 agttttttct aataaatgtg ccatttttca cctcgaattt aatc
//
LOCUS       DAVLHC010000035        18985 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.035, whole genome shotgun sequence.
ACCESSION   DAVLHC010000035 DAVLHC010000000
VERSION     DAVLHC010000035.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 18985)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18985)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18985
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.035"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(21..2180)
                     /locus_tag="VXE25_001499"
     CDS             complement(21..2180)
                     /locus_tag="VXE25_001499"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001040003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PBP1A family penicillin-binding protein"
                     /protein_id="HEV0771942.1"
                     /translation="MNKPTILRLIKYLSISFLSLVIAAIVLGGGVFFYYVSKAPSLSE
                     SKLVATTSSKIYDNKNQLIADLGSERRVNAQANDIPTDLVKAIVSIEDHRFFDHRGID
                     TIRILGAFLRNLQSNSLQGGSTLTQQLIKLTYFSTSTSDQTISRKAQEAWLAIQLEQK
                     ATKQEILTYYINKVYMSNGNYGMQTAAQNYYGKDLNNLSLPQLALLAGMPQAPNQYDP
                     YSHPEAAQDRRNLVLSEMKNQGYISAEQYEKAVNTPITDGLQSLKSASNYPAYMDNYL
                     KEVINQVEEETGYNLLTTGMDVYTNVDQEAQKHLWDIYNTDEYVAYPDDELQVASTIV
                     DVSNGKVIAQLGARHQSSNVSFGINQAVETNRDWGSTMKPITDYAPALEYGIYDSTAT
                     IVHDEPYNYPGTNTPVYNWDRGYFGNITLQYALQQSRNVPAVETLNKVGLNRAKTFLN
                     GLGIDYPSIHYSNAISSNTTESDKKYGASSEKMAAAYAAFANGGTYYKPMYIHKVVFS
                     DGSEKEFSNVGTRAMKETTAYMMTDMMKTVLSYGTGRNAYLAWLPQAGKTGTSNYTDE
                     EIENHIKTSQFVAPDELFAGYTRKYSMAVWTGYSNRLTPLVGNGLTVAAKVYRSMMTY
                     LSEGSNPEDWNIPEGLYRNGEFVFKNGARSTWSSPAPQQPPSTESSSSSSDSSTSQSS
                     STTPSTNNSTTTNPNNNTQQSNTTPDQQNQNPQPAQP"
     gene            complement(2177..2773)
                     /gene="recU"
                     /locus_tag="VXE25_001500"
     CDS             complement(2177..2773)
                     /gene="recU"
                     /locus_tag="VXE25_001500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000248773.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction resolvase RecU"
                     /protein_id="HEV0771943.1"
                     /translation="MVNYPHKVSSQKRQTSLSQPKNFANRGMSFEKMINATNDYYLSQ
                     GLAVIHKKPTPIQIVQVDYPQRSRAKIVEAYFRQASTTDYSGVYNGYYIDFEVKETKQ
                     KRAIPMKNFHPHQIQHMEQVLAQQGICFVLLHFSSQQETYLLPAFDLIRFYHQDKGQK
                     SMPLEYIREYGYEIKAGAFPQIPYLNVIKEHLLGGKTR"
     gene            2839..3366
                     /locus_tag="VXE25_001501"
     CDS             2839..3366
                     /locus_tag="VXE25_001501"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000179549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1273 domain-containing protein"
                     /protein_id="HEV0771944.1"
                     /translation="MATALVLGYSAFDLGLFSDKDPRLKLIKKAIRKDLEAMAADGVS
                     WLVFTGTLGFEYWVLEVAQEMKTEYGFQLATIFAFETHGENWNEGNQMKLSRFKQVDF
                     VKYAYPRYEHKGQLRDYQQFLLENTTSSYLFYDEENETKLAYFYQKMKNQEDYFIKRL
                     TFDQLNELAENFSEN"
     gene            3436..3765
                     /gene="gpsB"
                     /locus_tag="VXE25_001502"
     CDS             3436..3765
                     /gene="gpsB"
                     /locus_tag="VXE25_001502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000146522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division regulator GpsB"
                     /protein_id="HEV0771945.1"
                     /translation="MASIIFSAKDIFEQEFGREVRGYNKVEVDEFLDDVIKDYETYAA
                     LVKSLRQEIADLKEELTRKPKPSPVQAEPLEAAITSSMTNFDILKRLNRLEKEVFGKQ
                     ILDNSDF"
     gene            3786..4166
                     /gene="rnpB"
                     /locus_tag="VXE25_001503"
     ncRNA           3786..4166
                     /ncRNA_class="RNase_P_RNA"
                     /gene="rnpB"
                     /locus_tag="VXE25_001503"
                     /product="RNase P RNA component class B"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00011"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00011"
     gene            4251..5408
                     /locus_tag="VXE25_001504"
     CDS             4251..5408
                     /locus_tag="VXE25_001504"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000711388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent RNA methyltransferase"
                     /protein_id="HEV0771946.1"
                     /translation="MKKEFNLIATAAAGLEAVVGREVRELGYDCQIENGRVRFQGDVR
                     AIIETNLWLRAADRIKIIVGTFPAKTFEELFQGVFALDWENYLPLGARFPISKAKCVK
                     SKLHNEPSVQAISKKAVVKKLQKHYARPEGVPLMENGPEFKIEVSILKDVATVMIDTT
                     GSSLFKRGYRTEKGGAPIKENMAAAILQLSNWYPDKPLIDPTCGSGTFCIEAVMIARK
                     MAPGLRRSFAFEEWNWISDRLIQEVRTEAAKKVDRELELDIMGCDIDARMVEIAKANA
                     QAAGVAGDITFKQMRVQDLRSDKINGVIISNPPYGERLSDDAGVTKLYAEMGQVFAPL
                     KTWSKFILTSDEAFESKYGSQADKKRKLYNGTLKVDLYQYFGQRVKRQEVK"
     gene            5421..6791
                     /gene="mapZ"
                     /locus_tag="VXE25_001505"
     CDS             5421..6791
                     /gene="mapZ"
                     /locus_tag="VXE25_001505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000039255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mid-cell-anchored protein MapZ"
                     /protein_id="HEV0771947.1"
                     /translation="MSKKRRNRQKKEGQEPQFDFDEAKELTVGQAIRKNEEVEAGVLP
                     EDSILDKYVKQHRDEIEADKFATRQYKKEEFVETQSLDDLIQEMREAVEKSEASSEEV
                     PSSEDILLPLPLDDEEQGLDPLLLDDENPTEMTEEVEEEQNLSRLDQEDSEKKSKKGF
                     ILTVLALVSVIICVSAYYVYRQVARSTKEIETSQSTTANQSDVDDFNTLYDAFYTDSN
                     KTALKNSQFDKLNQLKTLLDKLEGSREHTLAKSKYDSLATQIKAIQDVNAQFEKPAIV
                     DGVLDANAKAKSDAKFTDIKTGNTELDKVLDKAISLGKSQQTSTSSSSSSQASSNTTS
                     EPKPSSSNETRSSRSEVNMGLSSAGVAVQRSASRVAYNQSAIDDSNNSAWDFADGVLE
                     QILATSRSRGYITGDQYILERVNIVNGNGYYNLYKPDGTYLFTLNCKTGYFVGNGAGH
                     ADDLDY"
     gene            6867..8291
                     /gene="gndA"
                     /locus_tag="VXE25_001506"
     CDS             6867..8291
                     /gene="gndA"
                     /locus_tag="VXE25_001506"
                     /EC_number="1.1.1.44"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004185725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-dependent phosphogluconate dehydrogenase"
                     /protein_id="HEV0771948.1"
                     /translation="MTKANFGVVGMAVMGRNLALNIESRGYTVAIYNRSKEKTEDVIA
                     CHPEKNFVPSYDVESFVNSIEKPRRIMLMVQAGPGTDATIQALLPHLNKGDILIDGGN
                     TFYKDTIRRNEELANSGINFIGTGVSGGEKGALEGPSIMPGGQKEAYELVSDVLEEIS
                     AKAPEDGKPCVTYIGPDGAGHYVKMVHNGIEYGDMQLIAESYDLMQHLLGLSAEDMAE
                     IFTEWNKGELDSYLIEITADILSRKDDEGQDGPIVDYILDAAGNKGTGKWTSQSSLDL
                     GVPLSLITESVFARYISTYKEERVYASKVLPKPAAFNFEGDKAELIEKIRQALYFSKI
                     ISYAQGFAQLRVASKENNWNLPFADIASIWRDGCIIRSRFLQKITDAYNRDADLANLL
                     LDEYFLDVTAKYQQAVRDIVALAVQAGVPVPTFSAAITYFDSYRSADLPANLIQAQRD
                     YFGAHTYQRKDKEGTFHYSWYDEK"
     gene            8303..8992
                     /locus_tag="VXE25_001507"
     CDS             8303..8992
                     /locus_tag="VXE25_001507"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000518023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEV0771949.1"
                     /translation="MGKRILLLEKERNLAHFLSLELQKEQYRVDLVEEGQKALSMALQ
                     TDYDLILLNVNLGDMMAQDFAEKLSRTKPASVIMILDHWEDLQEELEVVQRFAVSYIY
                     KPVLIENLVARISAIFRGRDFIDQHCSLMKVPRTYRNLRIDVEHHTVYRGEEMIALTR
                     REYDLLATLMGSKKVLTREQLLESVWKYESATETNIVDVYIRYLRSKLDVKGQKSYIK
                     TVRGVGYTIQE"
     gene            9090..10109
                     /gene="cbpC"
                     /locus_tag="VXE25_001508"
     CDS             9090..10109
                     /gene="cbpC"
                     /locus_tag="VXE25_001508"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000771060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline-binding protein CbpC"
                     /protein_id="HEV0771950.1"
                     /translation="MKLLKKMMQVLLAVFFFGLLATNTVFANTTGGRFVDKDNRKYYV
                     KDDHKAIYWHKIDGKTYYFGDIGEMVVGWQYLEIPGTGYRDNLFDNQPVNEIGLQEKW
                     YYFGQDGALLEQTDKQVLEAKTSENTGKVYGEQYPLSAEKRTYYFDNNYAVKTGWIYE
                     EGHWYYLNKLGNFGDDSYNPLPIGEVAKGWTQDFHVTIDIDRSKPAPWYYLDPTTGIM
                     QTGWQYLGNKWYYLRSSGAMATGWYQEGTTWYYLDHPNGDMKTGWQNLGNKWYYLRSS
                     GAMATGWYQDGSTWYYLNAGNGDMKTGWFQVNGNWYYAYSSGALAVNTTVDGYSVNYN
                     GEWVR"
     gene            10231..11109
                     /gene="mvk"
                     /locus_tag="VXE25_001509"
     CDS             10231..11109
                     /gene="mvk"
                     /locus_tag="VXE25_001509"
                     /EC_number="2.7.1.36"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mevalonate kinase"
                     /protein_id="HEV0771951.1"
                     /translation="MTKKVGVGQAHSKIILIGEHAVVYGYPAISLPLLEVEVTCKVVP
                     AESPWRLYEEDTLSMAVYASLEYLDITEACIRCEIDSAIPEKRGMGSSAAISIAAIRA
                     VFDYYQADLPHDVLEILVNRAEMIAHMNPSGLDAKTCLSDQPIRFIKNVGFTELEMDL
                     SAYLVIADTGVYGHTREAIQVVQNKGKDALPFLHALGELTQQAEVAISQKDAEGLGQI
                     LSQAHLHLKEIGVSSPEADFLVETTLSHGALGAKMSGGGLGGCIIALVTNLTHAQELA
                     ERLEEKGAVQTWIESL"
     gene            11091..12044
                     /gene="mvaD"
                     /locus_tag="VXE25_001510"
     CDS             11091..12044
                     /gene="mvaD"
                     /locus_tag="VXE25_001510"
                     /EC_number="4.1.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000373478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diphosphomevalonate decarboxylase"
                     /protein_id="HEV0771952.1"
                     /translation="MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYT
                     ETTLSPLPANVTADEFYINGQLQNEVEHAKMSKIIDRYRPAGEGFVRIDTQNNMPTAA
                     GLSSSSSGLSALVKACNAYFKLGLDRSQLAQEAKFASGSSSRSFYGPLGAWDKDSGEI
                     YPVETDLKLAMIMLVLEDKKKPISSRDGMKLCVETSTTFDDWVRQSEKDYQDMLIYLK
                     ENDFAKIGELTEKNALAMHATTKTASPAFSYLTDASYEAMDFVRQLREKGEACYFTMD
                     AGPNVKVFCQEKDLEHLSEIFGQRYRLIVSKTKDLSQDDCC"
     gene            12031..13038
                     /locus_tag="VXE25_001511"
     CDS             12031..13038
                     /locus_tag="VXE25_001511"
                     /EC_number="2.7.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000562378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomevalonate kinase"
                     /protein_id="HEV0771953.1"
                     /translation="MIAVKTCGKLYWAGEYAILEPGQLALIKDIPIYMRAEIAFSDSY
                     RIYSDMFDFAVDLRPNPDYSLIQETIALMGDFLAVRGQNLRPFSLKICGKMEREGKKF
                     GLGSSGSVVVLVVKALLALYNLSVDQNLLFKLTSAVLLKRGDNGSMGDLACIVAEDLV
                     LYQSFDRQKVAAWLEEENLATVLERDWGFFISQVKPTLECDFLVGWTKEVAVSSHMVQ
                     QIKQNINQNFLSSSKETVVSLVEALEQGKAEKVIEQVEVASKLLEGLSTDIYTPLLRQ
                     LKEASQDLQAVAKSSGAGGGDCGIALSFDAQSTETLKNRWADLGIELLYQERIGHDDK
                     S"
     gene            13022..14032
                     /locus_tag="VXE25_001512"
     CDS             13022..14032
                     /locus_tag="VXE25_001512"
                     /EC_number="5.3.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000210649.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type 2 isopentenyl-diphosphate Delta-isomerase"
                     /protein_id="HEV0771954.1"
                     /translation="MTTNRKDEHILYALEQKSSYNSFDEVELIHSSLPLYNLDEIDLS
                     TEFAGRKWDFPFYINAMTGGSNKGREINQKLAQVAESCGILFVTGSYSAALKNPTDDS
                     FSVKSSHPNLLLGTNIGLDKPVELGLQTVEEMNPVLLQVHVNVMQELLMPEGERKFRS
                     WQSHLADYSEQIPVPIVLKEVGFGMDAKTIERAYEFGVRTVDLSGRGGTSFAYIENRR
                     SGQRDYLNQWGQSTMQALLNAQEWKDKVELLVSGGVRNPLDMIKCLVFGAKSVGLSRT
                     VLELVETYTVEEVIGIVQGWKADLRLIMCSLNCATIADLQKVDYLLYGKLKEAKDQMK
                     KA"
     gene            14109..14807
                     /locus_tag="VXE25_001513"
     CDS             14109..14807
                     /locus_tag="VXE25_001513"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001224647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-active antibiotics response protein"
                     /protein_id="HEV0771955.1"
                     /translation="MRKFKIFLFIEACLLTGALILMVSEHFSRFLLILFLFLLLIRYY
                     TGKEGNNLLLVAATILFFFIVMLNPFVILAIFVAVIYSLFLLYPMMNQEKEQTNLVFE
                     EVVTVKKEKNRWFGNLHHFSSYQTCQFDDINLFRFMGKDTIHLERVILTNHDNVIILR
                     KMVGTTKIIVPVDVEVSLSVNCLYGDLTFFNQPKRALRNEHYHQETKDYLKSNKSVKI
                     FLTTMIGDVEVVRG"
     gene            14804..15799
                     /locus_tag="VXE25_001514"
     CDS             14804..15799
                     /locus_tag="VXE25_001514"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEV0771956.1"
                     /translation="MKKQAYVIIALTSFLFVFFFSHNLLEILDFDWSIFLHDVEKTEK
                     FVFLLLVFSMSITCLLALFWRGIEELSLRKMQANLKRLLAGQEVVQVADPDLDASFKS
                     LSGKLNLLTEALQKAENHSLAQEEEIIEKERKRIARDLHDTVSQELFAAHMILSGISQ
                     QALKLDREKMQTQLQSVTAILETAQKDLRVLLLHLRPVELEQKSLIEGIQILLKELED
                     KSDLRVSLKQNMTKLPKKIEEHIFRILQELISNTLRHAQASCLDVYLYQTDVELQLKV
                     VDNGIGFQLGSLDDLSYGLRNIKERVEDMAGTVQLLTAPKQGLAVDIRIPLLDKE"
     gene            15813..16445
                     /locus_tag="VXE25_001515"
     CDS             15813..16445
                     /locus_tag="VXE25_001515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEV0771957.1"
                     /translation="MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALE
                     LRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIVTSYLDNEKIMPVLDAGAKGYML
                     KTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
                     ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQDEF"
     gene            16446..16688
                     /locus_tag="VXE25_001516"
                     /pseudo
     CDS             16446..16688
                     /locus_tag="VXE25_001516"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812384.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DNA alkylation repair protein"
     gene            16613..16924
                     /locus_tag="VXE25_001517"
     CDS             16613..16924
                     /locus_tag="VXE25_001517"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004250000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA alkylation repair protein"
                     /protein_id="HEV0771958.1"
                     /translation="MDWDFADTCWEKEPRKYQYVAANYLKAMQSYLKETDLPKLEQLV
                     VTKSWWDTVDILDRVVGSLVYEHPELEEIILILFENLFKPRQLYLQPQNSVLSNLRLA
                     S"
     gene            16949..17215
                     /locus_tag="VXE25_001518"
                     /pseudo
     CDS             16949..17215
                     /locus_tag="VXE25_001518"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000060522.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DNA alkylation repair protein"
     gene            17365..17604
                     /locus_tag="VXE25_001519"
     CDS             17365..17604
                     /locus_tag="VXE25_001519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000754500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0771959.1"
                     /translation="MKKTVYKKLGISIIASTLLASQLSTVSALSVISSTGEEYEVSET
                     LEKGPESNDSSLSEISPTYGSYYQKQSEVLSVMMI"
     gene            17649..18278
                     /locus_tag="VXE25_001520"
     CDS             17649..18278
                     /locus_tag="VXE25_001520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine protease"
                     /protein_id="HEV0771960.1"
                     /translation="MVLSKYYGVADGMNVEGRGSANFIKDNVLITAAHNYYRHDYGKE
                     ADDIYVLPAVSPSQELFGKIKVKEVRYLKEFRNLNSKDAREYDLALLILEEPIGAKLG
                     TLGLPTSQKNLTGITVTITGYLSYNFKIHQMYTDKKQVLSDDGMFLDYQVDTLEGSSG
                     STVYDASHRVVGVHTLGDGANQINSAVKLNERNLPFIYSVLKGYSLEGW"
     gene            18577..18969
                     /locus_tag="VXE25_001521"
     CDS             18577..18969
                     /locus_tag="VXE25_001521"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HEV0771961.1"
                     /translation="MDSPKSLASYRVIGISDRVLEILKEYLLLEEGDYIFTNNGSPLM
                     ITCFNYFLKNSFRKSEIKKDDFVLTAHVFRYSHISLLAELEVPITAIMDRVDYTNETK
                     ILSVYTHVTEKMKSNITEKLDKLVLEND"
BASE COUNT         5628 a         3341 c         4430 g         5586 t
ORIGIN      
        1 aaaaatctgg atgataaatg ttatggttgt gctggttgag gattctgatt ttgttgatca
       61 ggggttgtat ttgattgttg cgtattattg ttaggattgg tagtcgtact attatttgtg
      121 cttggagtgg ttgagctaga ctgtgaagtt gaactatctg atgatgagct tgaactttca
      181 gttgatgggg gttgttgtgg agcaggtgag ctccacgtag aacgagcacc atttttaaat
      241 acgaattctc catttctgta gagcccctct ggtatattcc aatcctctgg attgcttcct
      301 tcagacaggt aggtcatcat agagcggtaa actttggcag cgaccgtaag gccattgcct
      361 acaagtggtg tcagacggtt agaatagcct gtccatacag ccattgaata tttacgcgta
      421 tagccagcaa atagttcatc aggtgctaca aattgagagg tcttgatgtg gttttcaatt
      481 tcctcgtctg tatagttaga ggttcctgtt ttaccagcct gagggagcca agcaagatag
      541 gcatttcgtc cagttccata actcaagact gttttcatca tgtcggtcat catataggct
      601 gtcgtttcct tcatggcacg agttccgaca ttagagaact ctttttcact cccatcacta
      661 aagacgactt tatggatata cattggttta tagtaagttc caccatttgc aaaggcagcg
      721 taagcagcag ccatcttttc actacttgct ccatattttt tgtctgattc ggttgtgtta
      781 cttgaaatgg catttgagta gtgaatactt gggtagtcga ttccgagacc atttaggaaa
      841 gtcttggcgc ggttgagtcc gaccttgttt agagtttcca cggctgggac gtttcgcgat
      901 tgttgcaggg cgtattgcaa ggtgatgttg ccaaagtagc ccctatccca gttataaaca
      961 ggggtatttg tcccagggta gttatagggc tcatcgtgaa cgatagtagc agttgaatcg
     1021 tagataccgt actccaaggc aggagcatag tctgtgatcg gtttcatagt tgatccccag
     1081 tcgcggtttg tttctactgc ttggttaatt ccgaaggaaa cattacttga ctgatggcgt
     1141 gctcctagct gggcaatgac tttaccgtta gaaacatcaa caatggtaga agcgacttgc
     1201 aattcatcgt ctggataggc aacgtattcg tctgtattgt aaatatccca cagatgtttt
     1261 tgagcttctt ggtctacatt tgtgtagaca tccatcccag ttgtgagcag gttatagcct
     1321 gtttcttctt caacttgatt gatgacttcc ttgaggtaat tatccatgta agcagggtaa
     1381 ttacttgctg atttgagact ttgtagtcca tcagtaattg gtgtattgac tgctttctca
     1441 tactgttcag cagagatgta gccttgattt ttcatttcag ataagaccaa gtttcggcgg
     1501 tcttgggctg cttctggatg tgaatagggg tcatattggt ttggtgcctg aggcattcca
     1561 gccagcaagg ctaactgagg taaacttaaa ttattgaggt ctttaccata gtagttttga
     1621 gctgctgtct gcattccata gttcccatta gacatgtaga ccttatttat atagtaggtc
     1681 aagatttctt gcttggttgc tttttgttct aactgaatcg ctaaccaagc ttcctgagcc
     1741 ttacgagaaa tagtctggtc ggaagtcgaa gttgaaaagt aagtcaactt aatcaactgt
     1801 tgggtgagag ttgatccacc ttggagggaa ttgctttgca gattgcgcaa gaaagctccc
     1861 aggatacgga tggtatcaat ccccctgtgg tcgaagaagc gatggtcttc gatagaaacg
     1921 attgccttaa ccaaatctgt gggaatatca ttagcttggg cattgacgcg gcgttcagaa
     1981 cccaagtcag caatgagttg atttttattg tcgtagattt tactagaagt tgttgcaact
     2041 agtttactct cggataggct aggagccttg ctaacgtagt agaaaaaaac tcctccgcct
     2101 aagacaatgg ctgcgataac caagcttaag aagctaatgc tcagatactt gattaggcgc
     2161 agaatcgttg gtttgttcat cttgttttac cacctaataa atgttctttg ataacattga
     2221 gataaggaat ttgagggaag gcaccagcct tgatttcata tccatattct cgaatatatt
     2281 caagtggcat tgatttttgt cccttatctt gatgatagaa gcgaatcaaa tcgaatgccg
     2341 gcaataagta ggtttcttgc tgagaagaaa agtgaagaag gacaaagcag attccttgtt
     2401 gggcaaggac ttgttccata tgctgaatct gatgtggatg aaaatttttc atcggaatcg
     2461 cacgtttttg ttttgtttcc ttgacttcaa agtcgatgta atatccatta taaacgccag
     2521 aatagtccgt cgttgaagct tgtcgaaaat aggcttcaac aatcttggca cgacttcgtt
     2581 gtggatagtc cacttgtacg atttgaatag gagttggttt cttatgtata acagccaagc
     2641 cctgagacaa atagtagtcg ttggtagcat tgatcatctt ttcaaaagac attcctcgat
     2701 ttgcgaaatt tttgggttga gaaagagatg tttgtctttt ttgtgatgaa actttatgtg
     2761 gatagttgac cataattctc cttattggta caataacatc actttattat accataattt
     2821 gcacagaaag ggttaaaaat ggctacagct ttggttttag gctattctgc ttttgatttg
     2881 ggtttatttt ctgataagga tcctcgtctt aaattgatta aaaaagcgat acgtaaagat
     2941 ttagaggcta tggcagcaga tggggtgtct tggcttgtgt ttacagggac tttgggcttt
     3001 gaatattggg ttttagaggt tgctcaggag atgaaaaccg aatacggttt ccagttggcc
     3061 accatttttg cttttgaaac ccatggggaa aattggaatg aaggcaatca gatgaaactg
     3121 agtcgcttta agcaggtaga ctttgtcaaa tatgcctatc ctcgctatga acacaagggg
     3181 cagttaagag attaccagca gtttttgctg gaaaacacga ctagttccta tcttttttat
     3241 gatgaagaaa atgaaacaaa actagcttat ttttaccaaa agatgaaaaa tcaagaggac
     3301 tattttataa agagattaac atttgatcaa ttaaatgaac ttgctgaaaa tttttccgaa
     3361 aattgaagct ttgaccttga tttttgtttg ccttttttta tataataata ctagcaagcg
     3421 agaatggaga gagacatggc aagtattatt ttttcagcga aagatatttt tgaacaggag
     3481 tttggacgtg aagtccgtgg ctataataaa gtagaagttg acgagttttt agacgatgtc
     3541 atcaaggact atgaaaccta tgctgccttg gtcaagtcac ttcgtcagga aattgcggat
     3601 ttgaaggaag aattaactcg taaaccgaaa ccttcaccag ttcaagcaga accccttgaa
     3661 gcggcaatta caagttctat gacgaatttt gatattttga aacgcctgaa tagattggaa
     3721 aaagaagttt ttggtaaaca aattttagat aactcagatt tttaagtagt tatttgagat
     3781 gtgcaatttt tggataatcg cgtgaggaga attgcttctc atgaggaaag tccatgctag
     3841 cacaggctgt gatgcctgta gtgtttgtgc taggcgaaac cataagccta gggacgagaa
     3901 atcgttacgg cagttgaaat ggctaagtcc ttggataggc cagagtaggc ttgaaagtgc
     3961 cacagtgacg aagtctttct ggaaacagag agagtggaac gcggtaaacc cctcaagcta
     4021 gcaacccaaa ttttggtcgg ggcatggagt acgcggaaac gaacgtagta ttctgactgc
     4081 tatcagctag agctgttagt ggtagacaga tgattatcga aggaagtggt cctagtcact
     4141 tctggaacaa aacatggctt atagaaaatt gcatataggt tggggctgag aaattttctc
     4201 aacctcattt tttaaagtgg acatatagaa aggtcttgca agactgtaac atgaaaaaag
     4261 aatttaattt aattgcaact gcggcagcag ggcttgaggc tgtcgttggt cgtgaagtgc
     4321 gagagttggg ctacgattgt cagattgaaa atggacgtgt tcgttttcaa ggagacgtga
     4381 gagctattat cgaaaccaac ctttggctgc gggcagcaga tcgtatcaaa attatcgtag
     4441 gaacgttccc tgctaagact tttgaagagc tatttcaggg agttttcgct ttagattggg
     4501 aaaattattt accacttgga gctcggttcc cgatttcaaa agctaaatgt gttaagtcca
     4561 aacttcacaa tgagcccagt gttcaggcta tttctaagaa agctgttgtc aagaaattgc
     4621 agaaacacta tgctcgccca gaaggggttc ctctgatgga gaatggccca gagtttaaga
     4681 ttgaggtctc tattctcaaa gatgtggcaa ctgtcatgat tgatacgacc gggtctagcc
     4741 tctttaaacg tggttatcgt accgaaaaag gtggcgctcc tatcaaggaa aatatggcag
     4801 cagccatttt acaactttct aactggtatc cagacaagcc tttgattgat ccgacctgtg
     4861 gttcggggac tttctgtatt gaggcagtta tgattgctag aaagatggcg ccaggtcttc
     4921 gtcgctcttt tgcatttgag gaatggaact ggatcagcga tcgcttgatt caagaagtgc
     4981 gcacagaagc ggctaaaaaa gtagaccgtg agcttgagct ggatatcatg ggctgtgata
     5041 ttgatgctcg catggtggaa attgctaagg ccaatgctca ggcagctggt gttgcaggag
     5101 acattacttt taagcagatg cgcgtgcagg atttacgttc cgataaaatc aatggagtaa
     5161 tcatttccaa tccgccttat ggtgaacgtt tgtcagatga tgcaggggtg accaagctct
     5221 atgctgagat ggggcaagta tttgcaccgc tgaaaacttg gagcaaattt atcctgacta
     5281 gtgatgaagc ttttgaaagc aagtatggta gccaagcaga taagaagcgt aagttataca
     5341 acggaacctt gaaagtggat ctgtatcaat attttggtca gcgtgtcaaa cggcaagagg
     5401 taaaatagaa agggatactc atgagtaaaa aaagacgaaa tcgtcaaaaa aaagaaggtc
     5461 aagaaccgca atttgatttt gatgaagcaa aagagctaac agttggtcaa gctattcgta
     5521 aaaatgaaga agtggaagca ggagtcttgc ctgaggattc cattttggac aagtatgtta
     5581 agcaacacag agatgaaatt gaggcggata agtttgcgac tcgtcaatac aaaaaagagg
     5641 agttcgttga aactcagagt ctggatgatt taattcaaga gatgcgtgag gctgtagaga
     5701 agtcagaagc ttcttcggag gaagttccat cttctgaaga catcttacta cccttgcctc
     5761 tggacgatga ggagcaaggc ttggatcctc tattgctaga tgatgaaaat ccaacagaaa
     5821 tgactgaaga agtggaagag gagcaaaacc tttctcgtct ggatcaagag gactcagaaa
     5881 agaaaagtaa aaaaggcttt attttgaccg ttttggcgct tgtatcagta attatttgtg
     5941 tcagtgctta ttatgtctac cgtcaagtgg ctcgttcgac caaggaaatt gaaacttctc
     6001 aatcaactac agccaatcaa tcggatgtgg atgattttaa tacactttat gacgcctttt
     6061 acacagatag caataaaacg gctttgaaaa atagccagtt tgataaactg aatcaactca
     6121 agactttact tgataagctg gaaggtagtc gtgaacatac gcttgccaaa tctaaatatg
     6181 atagtctagc aacgcaaatc aaggctattc aagatgtcaa tgctcaattt gagaaaccag
     6241 ctattgtgga tggtgtgttg gatgccaatg ccaaagccaa atcggatgct aaatttacgg
     6301 atattaaaac tggaaatacg gagcttgata aagtgctaga taaggctatc agtcttggta
     6361 agagccagca aacaagtact tctagctcaa gttcaagtca agcaagctca aatacgacaa
     6421 gtgagccaaa accaagtagt tcaaatgaga ctagaagtag tcgcagtgaa gtcaatatgg
     6481 gtctctcgag tgcaggggtt gctgttcaaa gaagtgccag tcgtgttgcc tataatcagt
     6541 ctgctattga tgatagtaat aactctgcct gggattttgc ggatggtgtc ttagaacaaa
     6601 ttctagcgac ttcacgttca cgtggctata tcactggaga ccaatatatc cttgaacgtg
     6661 tcaatatcgt taacggcaat ggttattaca acctctacaa gccagatgga acctatctct
     6721 ttacccttaa ctgtaagaca ggctactttg tcggaaatgg cgctggtcat gcggatgact
     6781 tggactacta agcagtcgtt acaaaattct ttcttttcaa aagtaaaaat gataaaataa
     6841 aacaaatgaa acaagaggag tgtcaaatga caaaagctaa ctttggtgtc gtaggtatgg
     6901 ccgtaatggg tcgtaacctt gcccttaata ttgaatctcg tggttacaca gttgctatct
     6961 acaaccgtag taaagaaaaa acggaagatg tgattgcttg ccatcctgaa aaaaactttg
     7021 taccaagcta tgacgttgaa agttttgtaa actcaatcga aaaacctcgt cgtatcatgc
     7081 tgatggttca agctggacct ggtacagatg ctactatcca agcccttctt ccacacctta
     7141 acaaggggga tatcttgatt gacggaggaa atactttcta caaagatacc atccgtcgta
     7201 atgaagaatt ggcaaactca ggtatcaact ttatcggtac tggggtttct ggtggtgaaa
     7261 aaggtgccct tgaaggtcct tctatcatgc ctggtggaca aaaagaggcc tacgaattgg
     7321 tttcggatgt tcttgaagaa atctcagcta aagcaccaga agatggcaaa ccatgtgtga
     7381 cttatatcgg tcctgatgga gctggtcact atgtgaaaat ggttcacaac ggtatcgagt
     7441 acggtgatat gcaattgatc gcagaaagtt atgacttgat gcaacacttg ctaggtcttt
     7501 ctgcagagga tatggctgaa atctttactg agtggaacaa gggtgaattg gatagctact
     7561 tgatcgaaat cacagctgat atcttgagcc gtaaagacga tgaaggccaa gatggaccaa
     7621 tcgtagacta catccttgat gctgcaggta acaagggaac tggtaaatgg actagccaat
     7681 catctcttga ccttggtgta ccattgtcac tgattactga gtcagtgttt gcacgctaca
     7741 tttcaactta caaagaagaa cgtgtatatg ctagcaaggt gcttccaaaa ccagctgcct
     7801 tcaactttga aggagacaag gctgaattga ttgaaaagat ccgtcaagcc ctttacttct
     7861 caaaaatcat ttcatacgca caaggatttg ctcaattgcg tgtagcctct aaagaaaaca
     7921 actggaactt gccatttgca gatatcgcat ctatctggcg tgatggctgt atcatccgtt
     7981 ctcgtttttt gcaaaagatt acagatgctt acaaccgcga tgcagatctt gccaaccttc
     8041 ttttggatga atacttcttg gatgttactg ctaagtatca acaagcagtg cgtgatatcg
     8101 tagctcttgc ggttcaagct ggtgtgccag tgccaacttt ctcagcagct attacttact
     8161 ttgatagcta ccgttcagct gaccttccag ctaacttgat ccaagcacaa cgtgactact
     8221 ttggtgccca cacttaccaa cgtaaagaca aagaaggaac cttccactac tcttggtatg
     8281 acgaaaaata agtaggtcag ccatggggaa acggatttta ttacttgaga aagaacgaaa
     8341 tctagctcat tttttaagtt tggaactcca gaaagagcag tatcgggttg atctggtaga
     8401 ggaggggcaa aaagccctct ccatggctct tcagacagac tatgatttga ttttattgaa
     8461 cgttaatctg ggagatatga tggctcagga ttttgcagaa aaattgagcc gaactaaacc
     8521 tgcctcagtc atcatgattt tagatcattg ggaagacttg caagaagagc tggaagttgt
     8581 tcagcgtttt gcagtttcat acatctataa gccagtcctt atcgaaaatc tggtagcgcg
     8641 tatttcggcg atcttccgag gtcgggactt cattgatcaa cactgcagtc tgatgaaagt
     8701 tccaaggacc taccgcaatc ttaggataga tgttgaacat cacacggttt atcgtggtga
     8761 agagatgatt gctctgaccc gccgtgagta tgaccttttg gcgacactta tgggaagcaa
     8821 gaaagtattg actcgtgagc aattgttgga aagtgtttgg aagtatgaaa gtgcgaccga
     8881 gacaaatatc gtagatgtct atatccgcta tctacggagc aagcttgatg ttaaaggcca
     8941 aaaaagctac attaaaaccg tgcgtggtgt tggatatacc attcaagaat agataagcag
     9001 ttgcagttgt gtaactgctt ttttgaggag tttttatata ttgacatgca gtcgggtctt
     9061 tgctacaatc gttttaggag gatatataga tgaaactttt gaaaaaaatg atgcaagttc
     9121 tactagcagt ctttttcttt ggtttgctag ctacaaatac ggtatttgcg aataccacag
     9181 gtggccgatt tgttgataag gataatagaa aatattatgt aaaagatgat cataaagcaa
     9241 tctattggca taaaatagac ggtaaaactt actattttgg tgatattgga gagatggttg
     9301 tcggttggca atacttagaa attcctggaa caggttatcg tgataattta ttcgataacc
     9361 aaccagttaa tgaaattggc cttcaggaga agtggtacta ttttggacaa gatggtgctt
     9421 tgctagaaca aacagataaa caagtactag aggcaaaaac gtctgaaaat acaggaaaag
     9481 tatacggtga acaatatcct ctatctgctg aaaagagaac ttattatttt gataataatt
     9541 atgctgtaaa gacaggctgg atttatgaag agggtcattg gtattattta aataagctag
     9601 gaaattttgg cgatgattct tacaatccac taccaattgg tgaagttgct aagggttgga
     9661 ctcaagattt tcatgttact attgacattg atagaagcaa acctgctcca tggtactacc
     9721 tagatccaac aactggtatt atgcaaacag gttggcaata tctaggtaat aagtggtact
     9781 acctccgttc ctcaggagca atggccactg gctggtatca ggaaggtacc acttggtatt
     9841 atttagacca cccaaatggc gatatgaaaa caggttggca aaaccttggg aacaaatggt
     9901 actatctccg ttcatcagga gctatggcaa ctggttggta tcaagatggt tcaacttggt
     9961 actacctaaa tgcaggtaat ggagacatga agacaggttg gttccaggtc aatggcaact
    10021 ggtactatgc ttatagctca ggtgccttgg cagtgaatac gactgtagat ggctattctg
    10081 tcaattataa tggtgaatgg gttcggtaat gaaagaagtg attgtgaatg gaaacaatcg
    10141 ctttttttgt gaaaatataa taaaatagat aggaaagaat taatacttgt atgaaaaata
    10201 agacgttttt tcgtctagta aaaggaaaaa atgacaaaaa aagttggtgt cggtcaggca
    10261 catagtaaga taattttaat aggggaacat gcggtcgttt acggttatcc tgccatttcc
    10321 ctgcctcttt tggaggtgga ggtgacctgt aaggtagttc ctgcagagag tccttggcgc
    10381 ctttatgagg aggatacctt gtccatggcg gtttatgcct cactggagta tttggatatc
    10441 acagaagcct gcattcgttg tgagattgac tcggctatcc ctgagaaacg ggggatgggt
    10501 tcgtcagcgg ctatcagcat agcggccatt cgtgcggtat ttgactacta tcaggctgat
    10561 ctgcctcatg atgtactaga aatcttggtc aatcgagctg aaatgattgc ccatatgaat
    10621 cctagtggtt tggatgctaa gacctgtctc agtgaccaac ctattcgctt tatcaagaac
    10681 gtaggattta cagaacttga gatggattta tccgcctatt tggtgattgc cgatacgggt
    10741 gtttatggtc atactcgtga agccatccaa gtggttcaaa ataagggcaa ggatgcccta
    10801 ccgtttttgc atgccttggg agaattaacc cagcaagcag aagttgcgat ttcacaaaaa
    10861 gatgctgaag gactgggaca aatcctcagt caagcgcatt tacatttaaa agaaattgga
    10921 gtcagtagcc ctgaggcaga ctttttggtt gaaacgactc ttagccatgg tgctctgggt
    10981 gccaagatga gcggtggtgg gctaggaggt tgtatcatag ccttggtaac caatttgaca
    11041 cacgcacaag aactagcaga aagattagaa gagaaaggag ctgttcagac atggatagag
    11101 agcctgtaac agtacgttcc tacgcaaata ttgctattat caaatattgg ggaaagaaaa
    11161 aagaaaaaga gatggtgcct gctactagca gtatttctct aactttggaa aatatgtata
    11221 cagagacgac cttgtcgcct ttaccagcca atgtaacagc tgacgaattt tacatcaatg
    11281 gtcagctaca aaatgaggtc gagcatgcca agatgagtaa gattattgac cgttatcgtc
    11341 cagctggtga gggctttgtc cgtatcgata ctcaaaacaa tatgcctacg gcagcgggcc
    11401 tgtcctcaag ttctagtggt ttgtccgccc tggtcaaggc ttgtaatgct tatttcaagc
    11461 ttggattgga tagaagtcag ttagcgcagg aagccaagtt tgcctcaggc tcttcttctc
    11521 ggagttttta tggaccacta ggagcctggg ataaggatag tggagaaatt taccctgtag
    11581 agacagactt gaaactagct atgattatgt tggtgctaga ggacaagaaa aaaccaatct
    11641 ctagccgtga cgggatgaaa ctttgtgtgg aaacctcgac gactttcgac gactgggttc
    11701 gtcagtctga gaaggactat caggatatgc tgatttatct caaggaaaat gattttgcca
    11761 agattggaga attaacggag aaaaatgccc tggctatgca tgctacgaca aagactgcta
    11821 gtccagcctt ttcttatctg acggatgcct cttatgaggc tatggacttt gttcgccagc
    11881 ttcgtgagaa aggagaggcc tgctacttta ccatggatgc tggtcccaat gttaaggtct
    11941 tctgtcagga gaaagacttg gagcatttat cagaaatttt cggtcagcgt tatcgcttga
    12001 ttgtgtcaaa aacaaaggat ttgagtcaag atgattgctg ttaaaacttg cggaaaactc
    12061 tattgggcag gtgaatatgc tattttagag ccagggcagt tagcgttgat aaaggatatt
    12121 cccatctata tgagggctga aattgctttt tctgacagct accgtatcta ttcagatatg
    12181 tttgatttcg cagtggactt aaggcctaat cctgactaca gcttgattca agaaacgatt
    12241 gctttgatgg gagacttcct cgctgttcgc ggtcagaatt taagaccttt ttccctaaaa
    12301 atctgtggca aaatggaacg agaagggaaa aagtttggtc taggttctag tggcagcgtc
    12361 gttgtcttgg ttgtcaaggc tttactggct ctctataatc tttcggttga tcagaatctc
    12421 ttgttcaagc tgactagcgc tgtcttgctc aagcgaggag acaatggttc catgggcgac
    12481 cttgcctgta ttgtggcaga ggatttggtt ctctaccagt catttgatcg ccagaaggtg
    12541 gctgcttggt tagaagaaga aaacttggcg acagttctgg agcgtgattg gggatttttt
    12601 atctcacaag tgaaaccaac tttagaatgt gatttcttag tgggatggac caaggaagtg
    12661 gctgtatcga gtcacatggt ccagcaaatc aagcaaaata tcaatcaaaa ttttttaagt
    12721 tcctcaaaag aaacggtggt ttctttggtc gaagccttgg agcaggggaa agccgaaaaa
    12781 gttatcgagc aagtagaagt agccagcaag cttttagaag gcttgagtac agatatttac
    12841 acgcctttgc ttagacagtt gaaagaagcc agtcaagatt tgcaggccgt tgccaagagt
    12901 agtggtgctg gtggtggtga ctgtggcatc gccttgagtt ttgatgcgca atcaaccgaa
    12961 accttaaaaa atcgttgggc cgatctgggg attgagctct tatatcaaga aaggatagga
    13021 catgacgaca aatcgtaagg atgagcatat cctctatgcc cttgagcaga aaagttccta
    13081 taatagcttt gatgaggtgg agctgattca ttcttccttg cctctttaca atctggatga
    13141 aatcgatctt tcgacagagt ttgctggtcg aaagtgggac tttccttttt atatcaatgc
    13201 catgactggt ggaagtaata agggaagaga aatcaatcaa aagctggctc aggtggcgga
    13261 atcctgtggt attttatttg taacgggttc ttatagcgca gccctcaaaa atccaacgga
    13321 tgattctttt tctgtcaagt ctagtcatcc caatctcctc cttggaacca atattggatt
    13381 ggacaagcct gtcgagttag gacttcagac tgtagaagag atgaatcctg ttctattgca
    13441 agtgcatgtc aatgtcatgc aggaattact catgcccgag ggagaaagga agtttagaag
    13501 ctggcaatcg catctagcag attatagcga gcaaattccc gttcctattg tcctcaagga
    13561 agtgggcttt ggaatggatg ccaagacaat cgaaagagcc tatgaattcg gtgttcgtac
    13621 agtggaccta tcgggtcgtg gtggcaccag ctttgcctat atcgaaaacc gtcgtagtgg
    13681 ccagcgtgat tacctcaatc aatggggtca gtctaccatg caggcccttc tcaatgccca
    13741 agaatggaaa gataaggtcg aactcttggt tagtggaggg gttcggaatc cgctggatat
    13801 gattaagtgc ttggtttttg gtgctaagtc tgtgggattg tcacgaaccg ttctggaatt
    13861 ggttgaaacc tacacagttg aagaagtgat tggcattgtc caaggctgga aagcagacct
    13921 acgcttgatt atgtgttccc ttaactgtgc caccatagca gatctacaaa aagtagacta
    13981 tcttctttat ggaaaattaa aagaagcaaa ggatcagatg aaaaaggcgt aaccagcgcc
    14041 ttttttccat cctcagactg aggtgacttt tttgaattgt gataaaatag aagggagagg
    14101 atgaacctat gagaaaattt aaaatctttt tatttatcga agcctgtctt ctgacaggag
    14161 ctctgatttt gatggtatca gagcattttt cgcgttttct gctgatacta ttcctctttt
    14221 tgcttttgat tcgctactac actggtaaag agggaaataa tcttctttta gtagcggcaa
    14281 ccattctctt ctttttcatc gttatgctca atccttttgt gattctagct atttttgttg
    14341 cggttatcta tagcctcttt cttctttacc cgatgatgaa ccaggaaaaa gagcagacca
    14401 atttggtttt tgaagaggtc gtgacggtta agaaggagaa aaatcgttgg tttggaaatc
    14461 ttcatcattt ttcaagctac cagacttgcc aattcgatga tatcaatctc tttcgcttca
    14521 tgggcaagga cactattcat ctggagaggg tcatcttaac caatcatgac aatgtcatta
    14581 tcctcagaaa gatggtagga acgaccaaaa tcatcgtacc tgtagatgtg gaagtcagtc
    14641 tcagcgttaa ctgtctctat ggggatttga cttttttcaa ccagcccaag cgagccctcc
    14701 gcaatgaaca ctatcatcaa gaaacaaaag actatctcaa gagtaacaag agtgtcaaga
    14761 ttttcttgac cactatgatt ggtgatgtgg aggtggttag aggatgaaaa aacaagccta
    14821 tgtcattatt gctctcacct ccttcctgtt tgtctttttt ttctcccaca acttgctgga
    14881 aatacttgat tttgactggt ctatcttttt gcacgatgtc gaaaaaacag aaaaatttgt
    14941 ctttttattg ttggttttca gcatgtccat aacctgtctc ttagccctgt tttggcgagg
    15001 gatcgaagag ctttctctaa gaaaaatgca ggctaatctc aagcgtttat tggcagggca
    15061 agaagtggtt caggttgcag atccagattt ggatgccagt ttcaagtcct tatcaggtaa
    15121 acttaacctt ttgacagaag ctcttcaaaa agctgaaaat catagccttg ctcaggaaga
    15181 ggaaatcatc gagaaggaac ggaagcgaat tgctcgggat ttgcacgata cagtcagtca
    15241 ggagttgttt gcggcccaca tgattttatc gggtatcagt cagcaggctt tgaaattgga
    15301 tagagaaaag atgcagaccc agttgcagag tgtcacagct attttagaaa cagcccagaa
    15361 ggatttgcgg gttttgctct tgcatttgcg accagttgaa ctggagcaga agagcttgat
    15421 agaagggatt caaattctct taaaagagct tgaggacaag agtgatctta gggttagtct
    15481 caagcagaat atgacgaaat tgcctaagaa aatcgaggag catatcttcc gtatcctgca
    15541 agagttgatt agcaatacgc tccgccatgc ccaggcatct tgcctagatg tctacctcta
    15601 tcagacagat gttgaattgc aactgaaggt ggtggacaat gggattggtt tccagttagg
    15661 gagcttagac gacttgagtt atggactgcg aaatatcaag gagcgggttg aagatatggc
    15721 agggacggtt cagttattaa cagctcccaa gcaagggctg gcagttgata tccgtattcc
    15781 cctgttagat aaggaatgat aaaggagtaa agatgaaaat tttactagta gatgaccatg
    15841 aaatggtccg tttgggcttg aaaagctact ttgacctcca agacgatgta gaagttgtgg
    15901 gtgaggcgtc caacgggtct caagggattg acttggcctt ggaactgcgt ccagatgtca
    15961 ttgtcatgga tattgtcatg cctgagatga atggaattga cgcgacctta gcaatcctta
    16021 aagaatggcc tgaagccaag attttgattg tgacctctta tttggacaat gaaaaaatca
    16081 tgccagtctt agatgctggt gccaaaggct atatgctcaa gacttctagt gcagatgaat
    16141 tgcttcatgc cgtcagtaag gtagctgctg gcgagctggc cattgagcaa gaggttagca
    16201 agaaggttga ataccaccgc aatcatatgg aacttcatga agaattgact gcgcgtgagc
    16261 gagatgttct ccaactcatc gccaagggct acgaaaatca gcgcatcgca gatgacctct
    16321 ttatctctct caagacggtc aagacccacg tgtccaacat tcttgccaaa cttgaagtca
    16381 gcgatcgtac ccaggcggct gtctatgcct ttcagcacca tttggtgggg caagatgagt
    16441 tttagatgag tttagcagat ttacttgagg agctagaagc agcaaaagac tctaaaaaag
    16501 caaggtccat ggaagcctat atgcgccatc aattttcttt tctaggtatt gcggtgcctg
    16561 aaagaaataa actctataaa aatatttact agaagcgaaa aaaacaaaga ttatcgattg
    16621 ggattttgca gacacttgct gggaaaagga gcctagaaaa taccaatatg tggctgctaa
    16681 ctatttgaaa gcaatgcagt cttatctaaa ggaaaccgat ttgcctaagc tagagcagtt
    16741 agtcgtgaca aaatcctggt gggacacggt agatatccta gatcgagtag tagggagttt
    16801 ggtgtatgaa caccctgaac tagaagaaat aatcttaata ctcttcgaaa atctcttcaa
    16861 accacgtcag ctctatctgc aacctcaaaa cagtgttttg agcaatctgc ggctagcttc
    16921 ctagtttgct ctttgatttt cattgagtat aaaatggagc ctatcagata atatctggct
    16981 gagacgtgtc gctattgacc accagttgtt aagaaaagag aagaccaata ctcaattaat
    17041 ggaaaagatt ctccttcata acttgaacca aacagaattt tttatcaata aagccattgg
    17101 ctggactctg cgagactact ccaaaacgaa tcccacttgg gtaacatgct ttattgagaa
    17161 aaacagggaa agaatggctg aacttagtat caaagaagca agtaagtacc tctagcgtga
    17221 ttgaaaagcg cagtcattaa ttgaaaagtt tacctgttta tgtgataatg gagggtattt
    17281 aaagaaggtg gtagatttct tgattctata gtagattaag aaatttagaa tagtacgcta
    17341 taattacatt aggaggacac aataatgaag aaaactgttt ataaaaaatt gggtatttca
    17401 attattgcga gtactttatt ggctagccag ttatcgacag tatctgcttt gagtgttatt
    17461 tctagtacag gtgaagaata tgaggtaagt gagacactag aaaaaggtcc agagtctaat
    17521 gattcttcat tatctgagat ttcaccaacg tatggttcat actaccaaaa gcaatcagaa
    17581 gtattatcgg taatgatgat ttgattaaaa ttgataatac tttacagtat ccgtattcga
    17641 cttcagctat ggttttatct aagtattatg gagtagccga tggaatgaat gtagaaggga
    17701 ggggaagtgc gaattttatt aaagataatg tgttaattac agcggctcac aactactaca
    17761 gacatgacta tgggaaagaa gcggatgata tttatgttct tccggctgtt agtccaagtc
    17821 aagaactatt tggaaagatc aaagtaaagg aagttcgtta tttgaaggaa tttagaaatt
    17881 taaattctaa ggatgcaagg gaatatgact tggctttatt aattctagaa gagcccattg
    17941 gtgcaaaatt agggactttg ggtcttccta ctagtcaaaa aaatttgaca ggaataactg
    18001 tgactatcac aggctatcta tcatataatt ttaaaattca tcaaatgtat acagataaaa
    18061 aacaagtttt aagtgatgat ggtatgttct tggattacca agttgatact ttagaggggt
    18121 ctagtggatc tacagtttat gatgctagtc accgtgtagt aggagtgcat actttaggag
    18181 atggagctaa tcaaattaac agtgcagtta aattaaatga acgaaatttg ccatttattt
    18241 attcggttct taaaggttac tctcttgaag gatggtgaat gggttaggta atgaaggcta
    18301 attgtaaact gtgatggata cttaactttg tataataggt ggataaaagt ctttaaaata
    18361 ggaaaaaacg catattatta ggtgtttaaa aaccttgata atatgcgttt tataatggaa
    18421 agatttcttc aattttgtct tgtatagtag attgaaacta taatagtaca cctctacttc
    18481 taaaacattg ttagaaattg atttgactgt cctgatcgat ttgtcctgtt cttatttcgt
    18541 tttactataa tgtaatcgtc caataacgaa gtatttttgg atagtccgaa aagtttagct
    18601 tcatatagag taattggtat tagtgataga gtgttagaaa ttttaaaaga atatcttctt
    18661 ttagaagaag gtgattatat atttacaaat aatggttctc ccttaatgat aacttgtttc
    18721 aattactttt tgaaaaacag ttttaggaaa agtgaaatta agaaagatga ttttgtattg
    18781 actgctcatg tttttagata ttcgcatata agtttgcttg ctgaattgga agtacctata
    18841 acagcgataa tggatcgtgt agattatact aatgaaacaa agattttaag tgtttatact
    18901 catgttactg agaagatgaa gtcaaatata actgaaaaat tagataaatt agttttggaa
    18961 aatgactaac caaaagatat ccaaa
//
LOCUS       DAVLHC010000036        18815 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.036, whole genome shotgun sequence.
ACCESSION   DAVLHC010000036 DAVLHC010000000
VERSION     DAVLHC010000036.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 18815)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18815)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18815
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.036"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            176..913
                     /locus_tag="VXE25_001522"
     CDS             176..913
                     /locus_tag="VXE25_001522"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEV0771962.1"
                     /translation="MTYTILIVEDEYLVRQGLTKLVNVAAYDMEIIGQAENGRQAWEL
                     IQKQVPDIILTDINMPHLNGIQLASLVRETYPQVHLVFLTGYDDFDYALSAVKLGVDD
                     YLLKPFSRQDIEEMLGKIKQKLDKEEKEEQLQDLLTNRFEGNMAQKIQSHLADSQFSL
                     KSLASDLGFSPTYLSSLIKKELGLPFQDYLVRERVKQAKLLLLTTDLKIYEIAEKVGF
                     EDMNYFTQRFKQIAGVTPRQFKKGEDR"
     gene            910..2601
                     /locus_tag="VXE25_001523"
     CDS             910..2601
                     /locus_tag="VXE25_001523"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEV0771963.1"
                     /translation="MKRSSLLVRMVISIFLVFLILLALVGTFYYQSSSSAIEATIEGN
                     SQTTISQTSHFIQSYIKKLETTSTGLTQQTDVLAYAENPSQDKVEGIRDLFLTILKSD
                     KDLKTVVLVTKSGQVISTDDSVQMKTSSDMMAEDWYQKAIHQGAMPVLTPARKSDSQW
                     VISVTQELVDARGANLGVLRLDISYETLEAYLNQLQLGQQGFAFIINENHEFVYHPQH
                     TVYSSSSKMEAMKPYIETGQGYTPGHKSYVSQEKIAGTDWTVLGVSSLEKLDQVRSQL
                     LWTLLGASVTSLLVCLCLVWFSLKRWIAPLKDLRETMLEIASGAQNLRAKEVGAYELR
                     EVTRQFNAMLDQIDQLMVAIRSQEETTRQYQLQALSSQINPHFLYNTLDTIIWMAEFH
                     DSQRVVQVTKSLATYFRLALNQGKDLICLSDEINHVRQYLFIQKQRYGDKLEYEINEN
                     VAFDNLVLPKLVLQPLVENALYHGIKEKEGQGHIKLSVQKQDSGLVIRIEDDGVGFQD
                     AGDSSQSQLKRGGVGLQNVDQRLKLHFGANYHMKIDSRPPKGTKVEIYINRIETS"
     gene            2717..3280
                     /locus_tag="VXE25_001524"
     CDS             2717..3280
                     /locus_tag="VXE25_001524"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01440 family protein"
                     /protein_id="HEV0771964.1"
                     /translation="MNETQIQRETRQVVEDVLEKTNLKQGALFVLGLSSSEVLGGQIG
                     KESSQEIGELIVETILDILGSRGIHLAVQGCEHVNRALVVERQVAEQFGLEIVSVHPT
                     LHAGGSGQLAAFKFMQDPVEVEFIKAHAGLDIGDTAIGMHVKHVQVPIRPILREIGHA
                     HVTALASRPKLIGGARAHYPQDAIRKT"
     gene            3302..8791
                     /locus_tag="VXE25_001525"
     CDS             3302..8791
                     /locus_tag="VXE25_001525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000473013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FIVAR domain-containing protein"
                     /protein_id="HEV0771965.1"
                     /translation="MFKKDRFSIRKIKGVVGSVFLGSLLMAPSVVDAATYHYVNKEII
                     SQEAKDLIQTGKPDRNEVVYGLVYQKDQLPQTGTEASVLTAFGYLSGDILKTLGLDTV
                     LEETSAKPGEVTVVEVETPQSTTNQEQARTENQVVETEEAPKEEAPKTEESPKEEPKS
                     EIKPTDDTLPKVEEGKEDSAEPAPVEEVGGEVESKPEEKVAVKPESQPSDKPTEEPKV
                     EQVGEPVEPSEDEQAPTAPVEPEKQPEAPEEEKAVEETPKPEDKIKGIGTKEPVDKSE
                     LNNQIDKASSVSPTDYSTASYNDLGPVLETAKGVYASEPVKQPEVNSETNKLKTAIDA
                     LNVDKSELQEQLRVAEQKQQADYSAKTWREFKIAELQAKEINNPTTPLPKQSEIDAAT
                     KALQDALQALAVDKTVLQNAINTANSKREEEYTAQTWKALKDALTAVNPVNEDETATQ
                     SKVDEATRNLEEAINNLVLLTEKPVLTFIETDKKALEREVVAKYSLENQNKTKIKSIT
                     ATLKKGETVVSTVELIGDDVTNETITSAFKNLEYYKEYTLSTTMVYDRGDGDVTEILD
                     NQPIQLDLKKVELKNIKRTDLIKYENGKETNESLITTVPDDKRNYYLKITSKNQKTTL
                     LAVKNIEETTVNGTPVYKVTAIADNLVSRTADNKFEEEYVHYIEKPKVHEDNVYYNFK
                     ELVEAIQNDPSKEYRLGQSMSARNVVPNGKSYITKEFTGKLLSSEGKQFAITELEHPL
                     FNVITNATINNVNFENVEIERSGQDNIASLANTMKGSSVITNVKITGTLSGRNNVAGF
                     VNNMNDGTRIENVAFFGKLHSTSGNGSHTGGIAGTNYRGIVRKAYVDATITGNKTRAS
                     LLVPKVDYGLTLDHLIGTKALLTESVVKGKIDVSNPVEVGAIASKTWPVGTVSNSVSY
                     AKIIRGEELFGSNDVDDSDYASAHIKDLYAVEGYSSGNRSFRKSKTFTKLTKEQADAK
                     VTTFNITADKLESDLSPLAKLNEEKAYSSIQDYNAEYNQAYKNLEKLIPFYNKDYIVY
                     QGNKLNKEHHLNTKEVLSVTAMNNNEFITNLDEANKIIVHYADGTKDYFNLSSSSEGL
                     SNVKEYTITDLGIKYTPNIVQKDNTTLVNDIKSILESVELQSQTMYQHLNRLGDYRVN
                     AIKDLYLEESFTDVKENLTNLITKLVQNEEHQLNDSPAARQMIRDKVEKNKAALLLGL
                     TYLNRYYGVKFGDVNIKELMLFKPDFYGEKVSVLDRLIEIGSKENNIKGSRTFDAFGQ
                     VLAKYTKSGNLDAFLNYNRQLFTNIDNMNDWFIDATEDHVYIAERASEVEEIKNSKHR
                     AFDNLKRSHLRNTILPLLNIDKAHLYLISNYNAIAFGSAERLGKKSLEDIKDIVNKAA
                     DGYRNYYDFWYRLASDNVKQRLLRDAVIPIWEGYNAPGGWVEKYGRYNTDKVYTPLRE
                     FFGPMDKYYNYNGTGAYAAIYPNSDDIRTDVKYVHLEMVGEYGISVYTHETTHVNDRA
                     IYLGGFGHREGTDAEAYAQGMLQTPVTGSGFDEFGSLGINMVFKRKNDGNQWYITDPK
                     TLKTREDINRYMKGYNDTLTLLDEIEAESVISQQNKDLNSAWFKKIDREYRDNNKLNQ
                     WDKIRNLSQEEKNELNIQSVNDLVDQQLMTNRNPGNGIYKPEAISYNDQSPYVGVRMM
                     TGIYGGNTSKGAPGAVSFKHNAFRLWGYYGYENGFLGYASNKYKQQSKTDGESVLSDE
                     YIIKKISNNTFNTIEEFKKAYFKEVKDKATKGLTTFEVNGSSVSSYDDLLTLFKEAVK
                     KDAETLKQEANGNKTVSMNNTVKLKEAVYKKLLQQTDSFKTSIFK"
     gene            8852..10573
                     /gene="pabB"
                     /locus_tag="VXE25_001526"
     CDS             8852..10573
                     /gene="pabB"
                     /locus_tag="VXE25_001526"
                     /EC_number="2.6.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001818774.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminodeoxychorismate synthase component I"
                     /protein_id="HEV0771966.1"
                     /translation="MHRKTVIDFRTLGERYTFTQPIKELKTRNVEEVADFLAQVESYQ
                     EQGYYVVGYVSYEAAPAFEEKLAVHKDPLLGEYLLYFTVHDSVETSPIPLTYEDIDLP
                     SNWQEVTSAADYEKAIAQIHHHLRQGDTYQVNYTVQLKQKLSANPFAIYNRMVVEQEA
                     GYNAYVEHDEMAVISMSPELFFEQNDRELTTRPMKGTTQRGVTDQEDLEQASWLEQDP
                     KNRSENMMIVDLLRNDMNRISEVGSEHVERLCQVEQYSTVWQMTSTIKSQLREDVDLV
                     EIFRSLFPCGSITGAPKIATMEIIKDLEPQPRGVYCGTIGLLLPNGRRIFNVAIRTIQ
                     LHKGQAIYGVGGGITWDSTWESEYREVHQKAAVLYRKQARFQLITTGEISQKNLLFED
                     QHLERLRKASRYFAFPFDAEDLGHKIEEECQDCEANRDYRLRISLSKSGEIEVNRQVL
                     TPLSTSFCQAQVCLQEAALNQSFTYFKTTHRPHLSLGEQEKIYHNKSGELLETSIGNL
                     VLKIAGKLYTPPIRLGILPGIYRQYLLETGQVEEKVLTLADLAQAEAIYGCNAVRGLY
                     ELILEEN"
     gene            10574..11191
                     /locus_tag="VXE25_001527"
     CDS             10574..11191
                     /locus_tag="VXE25_001527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000766583.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HEV0771967.1"
                     /translation="MKLIFLHGLGQSAESWKEVRNLLTDYPSEAIELFPSGVSNYQQA
                     KERVYQHLAQETEPFVLIGLSLGAALALELSSYDLPNLRALILSGCPLKLAGNILFYL
                     QLLIFKLLPKRVFEKQGADKALMVGVSEELKTLDLTDIAGTCPYPTLLICGIKDKPNL
                     SSMRSLHKLISESQFQIIPDGPHVLNKAKPKEFVEKTRSFLELLK"
     gene            11241..11999
                     /locus_tag="VXE25_001528"
     CDS             11241..11999
                     /locus_tag="VXE25_001528"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001042500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase family
                     protein"
                     /protein_id="HEV0771968.1"
                     /translation="MNKRLFLKMSLVTLPILALFSQPVLAEENIHFSSCKEAWANGYS
                     DLHEGEPGYSAKLDRDHDGVACELKNAPKGAFKAKQAATTQTDTTSSTASGWVKQDGS
                     WYYFDGNGNLVKNAWQGNYYLKADGKMAQSEWIYDSSYQAWYYLTSDGSYAYSTWQGN
                     YYLKSDGKMAVNEWVDGGRYYVGADGVWKEGQASTASSSNDSNSEYSAALGKAKSYNS
                     LFHMSKKRMYRQLTSDFDKFSNDAAQYAIDHLDD"
     gene            12126..13085
                     /locus_tag="VXE25_001529"
     CDS             12126..13085
                     /locus_tag="VXE25_001529"
                     /EC_number="2.7.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002919069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family glucokinase"
                     /protein_id="HEV0771969.1"
                     /translation="MSQKIIGIDLGGTSIKFAILTTAGEIQGKWSIKTNILDEGSHIV
                     DDMIESIQHRLDLLGLAAADFQGIGMGSPGVVDRDKGTVIGAYNLNWKTLQPIKQKIE
                     KALGIPFFIDNDANVAALGERWMGAGNNQPDVVFMTLGTGVGGGIVAEGKLLHGVAGA
                     AGELGHITVDFDQPIACTCGKKGCLETVASATGIVNLTRRYADEYEGDAALKRLIDNG
                     EEVTAKTVFDLAKEGDDLALIVYRNFSRYLGIACANIGSILNPSTIVIGGGVSAAGEF
                     LLQGVQKVYDENSFPQVRTSTKLALATLGNDAGVIGAASLVLQ"
     gene            13182..14021
                     /locus_tag="VXE25_001530"
     CDS             13182..14021
                     /locus_tag="VXE25_001530"
                     /EC_number="2.1.1.45"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003011065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thymidylate synthase"
                     /protein_id="HEV0771970.1"
                     /translation="MTKADTIFKENIERILKEGVFSEQARPKYKDGTVANSKYVTGAF
                     SEYDLSKGEFPITTLRPIAIKSAIKEVLWIYQDQSNSLEVLNDKYNVHYWNDWEVGDT
                     GTIGERYGAVVKKHDIINKLLKQLETNPWNRRNIISLWDYQAFEETDGLLPCAFQTMF
                     DVRRVDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNL
                     HIYDNQFEQAQELLRREPSNCQPRLVLNVPDGTNFFDIKAEDFELVDYDPVKPQLKFD
                     LAI"
     gene            complement(14069..14239)
                     /locus_tag="VXE25_001531"
     CDS             complement(14069..14239)
                     /locus_tag="VXE25_001531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001051775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3042 family protein"
                     /protein_id="HEV0771971.1"
                     /translation="MAKGFAKGLVTGVAGTVAAVAGAVYAFKKKVIEPEEQKAAFIEE
                     NRKKAARRRVSR"
     gene            14360..15244
                     /gene="miaA"
                     /locus_tag="VXE25_001532"
     CDS             14360..15244
                     /gene="miaA"
                     /locus_tag="VXE25_001532"
                     /EC_number="2.5.1.75"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000850191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (adenosine(37)-N6)-dimethylallyltransferase
                     MiaA"
                     /protein_id="HEV0771972.1"
                     /translation="MKTKIIVIVGPTAVGKTALAIEVAKRFNGEVVSGDSQQVYRGLD
                     IGTAKASPEEQAAVPHHLIDVREITESYSAFDFVSEAKMTIEDIHSRGKLAIIAGGTG
                     LYIQSLLEGYHLGGETPHEEILAYRASLEPYSDEELAHLVEQAGLEIPQFNRRRAMRA
                     LEIAHFGQDLENQETLYEPLIICLDDERSQLYERINHRVDLMFEAGLLDEAKWLFDHS
                     PNVQAAKGIGYKELFPYFRGEQTLEEASESLKQATRRFAKRQLTWFRNRMQVTFYQIG
                     ESGVQDRILSQIEEFLDD"
     gene            15237..16475
                     /gene="hflX"
                     /locus_tag="VXE25_001533"
     CDS             15237..16475
                     /gene="hflX"
                     /locus_tag="VXE25_001533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000573186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase HflX"
                     /protein_id="HEV0771973.1"
                     /translation="MIETEKKEERVLLIGVELQGMDSFDLSMEELASLAKTAGAVVVD
                     NYRQKREKYDSKTFVGSGKLEEIALMVDAEEITTVIVNNRLTPRQNVNLEEVLGVKVI
                     DRMQLILDIFAMRARSHEGKLQVHLAQLKYLLPRLVGQGIMLSRQAGGIGSRGPGESQ
                     LELNRRSVRNQITDIERQLKVVEKNRATVREKRLESSTFKIGLIGYTNAGKSTIMNIL
                     TSKTQYEADELFATLDATTKSIHLGGNLQVTLTDTVGFIQDLPTELVSSFKSTLEESK
                     HVDLLVHVIDASNPYHEEHEKTVLSIMKDLDMEDIPHLTLYNKADLVEDFTPTQTPYT
                     LISAKSEDSRENLQALLLDKIKEIFEAFTLRVPFSKSYKIHDLESVAILEERDYQEDS
                     EVITGYISEKNKWRLEEFYD"
     gene            16468..17091
                     /locus_tag="VXE25_001534"
     CDS             16468..17091
                     /locus_tag="VXE25_001534"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cystathionine beta-lyase"
                     /protein_id="HEV0771974.1"
                     /translation="MTDIKALALKYGGYTSLDKVYLDQLLAGKTEQEQLTLITPPPSV
                     VNAYFAELYQKKSPQAATDYFAELSQELNLYNTEPSFTLENKPFIRLNLSGKSFGFCY
                     DSDGLGRIFSENEEKISDDLLFEIAQIFPHQLVFEESGKIYMKPVEDEEVVSLESLTA
                     LTDLERLADGRKRLKGYSQEDLLQEAAAFSGKRYFRSENRTAMLYID"
     gene            17106..18035
                     /locus_tag="VXE25_001535"
     CDS             17106..18035
                     /locus_tag="VXE25_001535"
                     /EC_number="3.1.26.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000354350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease Z"
                     /protein_id="HEV0771975.1"
                     /translation="MDIQFLGTGAGQPSKARNVSSLALKLLDEINEVWLFDCGEGTQN
                     RILETTIRPRKISKIFITHLHGDHIFGLPGFLSSRAFQANEEQTDLEIYGPQGIKSFV
                     LTSLRVSGSRLPYRIHFHEFDQDSLGKILETDKFTVYAEELDHTIFCVGYRVMQKDLE
                     GTLDAEKLKAAGVPFGPLFGKIKNGQDLVLEDGTEIKAADYISAPRPGKIITILGDTR
                     KTDASVRLAVNADVLVHESTYGKGDEKIARNHGHSTNMQAAQVAVEAGAKRLLLNHIS
                     ARFLSKDISKLKKDAATIFENVHVVKDLEEVEI"
     gene            18056..18811
                     /locus_tag="VXE25_001536"
     CDS             18056..18811
                     /locus_tag="VXE25_001536"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001142149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family oxidoreductase"
                     /protein_id="HEV0771976.1"
                     /translation="MPTILITGASGGLAQEMVKLLPNDQLILLGRNKEKLAQLYGNYS
                     HAELIEIDITDDSALEALVTDLYLRYGKIDVLINNAGYGIFEGFDQIADKDIHQMFEV
                     NTFALMNLSRHLAARMKESSKGHIINIVSMAGLIATGKSSLYSATKFAAIGFSNALRL
                     ELMPYGVYVTTVNPGPIRTGFFDQADPDGTYLKSVDRFLLEADAVAKKIVKIIGKNKR
                     ELNLPILLNLAHKFYTLFPKLADKLVGETFNYK"
BASE COUNT         5999 a         3436 c         4105 g         5275 t
ORIGIN      
        1 gtactttgag ctgacttcgt cagttttatc tacaacctca aagcggtact ttgagaaacc
       61 tgtggctatc ttcctagttt actttttgat ttttattgag tataagaggt ctttcctaag
      121 cagttagagg agaattttgc tatactgata ctagtaagtg gtaaaggagc agagcatgac
      181 ctacacaatc ttaatcgtag aagatgaata tctggtaaga caaggtttga ctaaactggt
      241 caatgtagca gcctacgata tggaaatcat cggtcaggct gaaaatggaa ggcaggcttg
      301 ggaattgatc caaaagcagg tgccagatat cattttaacc gatatcaaca tgcctcatct
      361 aaatggcatc cagttggcca gtctggtacg agaaacctat cctcaggttc atttggtctt
      421 tttaacaggt tacgatgatt ttgattatgc cttgtctgct gtcaaactag gtgtggacga
      481 ctacctgctc aaaccctttt ctcgtcagga tattgaggaa atgttgggga aaatcaaaca
      541 aaaactagac aaggaagaga aagaagagca gttacaagat ttattgacta ataggtttga
      601 aggaaacatg gcccagaaaa tccagtctca tctggctgat agccaattta gtttaaagtc
      661 tttagccagt gacttaggtt ttagtccgac ctatctgagt tccttgatta agaaagagtt
      721 gggcttgcct tttcaggatt atctggtgag agaacgtgtt aaacaagcca agctcttgct
      781 tttaactaca gatctgaaga tttatgagat cgcagagaag gttggttttg aagatatgaa
      841 ctattttacc caacgtttta agcagattgc aggtgtgaca cctcgtcagt ttaagaaggg
      901 agaagaccga tgaagcgttc ttctctttta gttagaatgg ttatttccat ctttctggtc
      961 tttctcattc tcctagctct ggttggaact ttctactatc aatcaagttc ttcagccatt
     1021 gaggccacca ttgagggcaa cagccaaacg accatcagcc agactagcca ctttattcag
     1081 tcttatatca aaaaactaga aaccacctcg actggtttga cccagcagac ggatgttctg
     1141 gcctatgctg agaatcccag tcaagacaag gtcgagggaa tccgagattt gtttttgacc
     1201 atcttgaagt cagataagga cttgaaaact gttgtgctgg tgaccaaatc tggtcaggtc
     1261 atttctacag atgacagtgt gcagatgaaa acttcctctg atatgatggc tgaggattgg
     1321 taccaaaagg ctattcatca gggagctatg cctgttttga ctccagctcg taaatcagat
     1381 agtcagtggg tcatttctgt cactcaagaa cttgttgatg caaggggagc caatcttggt
     1441 gtgcttcgtt tggatatttc ttatgaaact ctggaagcct atctcaatca actccagttg
     1501 gggcagcagg gctttgcctt cattatcaat gaaaaccatg aatttgtcta ccatcctcaa
     1561 cacacagttt atagttcgtc tagcaaaatg gaggctatga aaccctacat cgagacaggt
     1621 cagggttata ctcctggtca caaatcctac gtcagtcaag agaagattgc aggaactgat
     1681 tggacggtac ttggcgtgtc atcattggaa aagttagacc aggttcggag tcagctcttg
     1741 tggaccttgc ttggggccag tgtcacatct cttcttgttt gtctctgctt agtgtggttc
     1801 agtcttaaac gctggattgc tcctttgaag gatttgagag aaaccatgtt ggaaattgct
     1861 tctggtgctc aaaatcttcg tgccaaggaa gttggtgcct atgaactgag agaagtaact
     1921 cgccaattta atgccatgtt ggatcagatt gatcagttga tggtagctat tcgtagccag
     1981 gaagaaacga cccgtcagta ccaacttcaa gccctttcga gccagattaa tccacatttc
     2041 ctctataaca ctttggacac catcatctgg atggctgaat ttcatgatag tcagcgagtg
     2101 gtgcaggtga ccaagtcctt ggcaacctat ttccgcttgg cgctcaatca aggcaaggac
     2161 ttgatttgtc tctctgacga aatcaatcat gtccgccagt atctctttat ccagaaacaa
     2221 cgctatggag ataagctgga atacgaaatt aatgaaaatg ttgcctttga taatttagtc
     2281 ttacccaagc tggtcctaca accccttgta gaaaatgctc tttaccatgg cattaaggaa
     2341 aaggaaggtc agggccatat taaactttct gtccagaaac aggattcggg attggtcatc
     2401 cgtattgagg atgatggcgt tggcttccaa gatgctggtg atagtagtca aagtcaactc
     2461 aaacgtgggg gagttggtct tcaaaatgtc gatcaacggc tcaaacttca ttttggagcc
     2521 aattaccata tgaagattga ttctagaccc ccaaaaggga cgaaagttga aatatatata
     2581 aatagaatag aaactagcta actcccagtc aattctggga gttttatgcg taattgggca
     2641 aactttctag gttgtctatc ttgctaaaaa caagaaaaaa cggtatgata gaagagtgac
     2701 aacagaggta acagagatga acgagacaca gattcaaaga gaaacacgtc aggtagtgga
     2761 agatgtttta gaaaagacca atttgaagca gggggccctt tttgttttag gtctatcttc
     2821 tagtgaggtg ctaggtggtc agattgggaa agaatccagt caagagattg gtgagctgat
     2881 agtggagact atcttggata ttctaggtag tagaggtatc catttagcag ttcaaggttg
     2941 tgagcatgtc aatcgggctc tcgttgttga acgtcaggtg gcagagcagt ttggtctgga
     3001 aattgtcagt gtccatccta ctcttcatgc aggaggttcg gggcagttgg cagcctttaa
     3061 gtttatgcag gatccagttg aggttgaatt tatcaaggct catgctggat tggatatcgg
     3121 agacactgca attggcatgc atgtcaagca tgttcaggtt ccgattcgcc ctattttgag
     3181 agagattggt catgcccatg taacggcact ggctagtcgt ccaaaattaa tcggaggtgc
     3241 gcgtgcgcac tatccgcaag atgctattag aaagacctga gaatgaataa aggagataaa
     3301 agtgtttaaa aaagaccgtt tttcaattcg taagattaag ggagttgtag gctctgtatt
     3361 tcttggaagc cttttgatgg ctccttctgt agtggacgca gccacctatc actatgtaaa
     3421 taaagagatt atttcacaag aagctaaaga tttaattcag acaggaaagc ctgacaggaa
     3481 tgaagttgta tatggtttgg tgtatcaaaa agatcagttg cctcaaacag ggacagaagc
     3541 atctgttttg acagcttttg gttatctatc aggtgacatc ctcaaaacgc ttggcttgga
     3601 cactgtttta gaagaaacct cagcaaaacc tggagaggtg actgtagtcg aagttgagac
     3661 tcctcaatca acaacaaatc aggagcaagc taggacagaa aaccaagtag tagagacaga
     3721 ggaagctcca aaagaagaag cacctaaaac agaagaaagt ccaaaggaag aaccaaaatc
     3781 ggagataaaa cctactgacg acacccttcc taaagtagaa gaggggaaag aagattcagc
     3841 agaaccagct ccagttgaag aagtaggtgg agaagttgag tcaaaaccag aggaaaaagt
     3901 agcagttaag ccagaaagtc aaccatcaga caaaccaaca gaggaaccaa aagttgaaca
     3961 agtaggtgaa ccagtcgagc caagtgaaga cgaacaggca ccaacggcac cagttgagcc
     4021 agaaaagcaa ccagaagctc ctgaagaaga gaaggctgta gaggaaacac cgaaaccaga
     4081 agataaaata aagggtattg gtactaaaga accagttgat aaaagtgagt taaataatca
     4141 aattgataaa gctagttcag tttctcctac tgattattct acagcaagtt acaatgatct
     4201 tggacctgtt ttagaaactg caaaaggtgt ctatgcttca gagcctgtaa aacagcctga
     4261 ggtaaatagt gagacaaata aacttaaaac ggctattgac gctctaaacg ttgataaaag
     4321 tgaattacag gaacaattaa gagttgctga acaaaaacaa caagctgact atagcgctaa
     4381 aacttggagg gaattcaaaa ttgctgaact tcaagctaaa gaaatcaaca acccaactac
     4441 accacttcct aaacaaagtg aaatagatgc agctactaag gctcttcaag acgctcttca
     4501 agctcttgct gtagataaaa ctgtattaca aaacgctatt aacacagcta atagcaaacg
     4561 tgaagaagag tatactgctc agacatggaa agcgttaaaa gatgctctta cagcagtgaa
     4621 tcctgttaat gaagatgaaa ctgcaactca aagcaaagta gacgaagcta ctagaaactt
     4681 agaagaagct atcaataacc tagttctatt aactgaaaaa ccggtattaa catttattga
     4741 gactgataag aaagcattag aacgtgaagt agttgctaag tattctctag aaaaccaaaa
     4801 taaaacaaaa attaaatcaa tcacagctac tctgaaaaaa ggagaaacag ttgttagcac
     4861 tgtagagctt ataggcgatg atgtaactaa tgaaactata acctctgcat ttaagaatct
     4921 agagtactac aaagaataca ccctatctac aactatggtt tacgatagag gtgacggtga
     4981 tgtaacagaa atcttagata atcaaccaat ccaactagat cttaaaaaag ttgagcttaa
     5041 aaatattaaa cgtacagatt taatcaaata cgaaaatgga aaagaaacta atgaatcact
     5101 aataacaact gttcctgatg ataagcggaa ttattattta aaaataactt caaagaatca
     5161 aaaaactaca ttactagctg ttaaaaatat agaagaaact acggttaacg gaacacctgt
     5221 atataaagtt acagcaatcg cagacaattt agtctctaga actgctgata ataaatttga
     5281 agaagaatac gttcactata ttgaaaaacc taaagtccac gaagataatg tatattataa
     5341 cttcaaagaa ttagtggagg ctattcaaaa cgatccttca aaagaatatc gtctgggaca
     5401 atcaatgagc gctagaaatg ttgttcctaa tggaaaatca tatatcacta aagaatttac
     5461 aggaaaactt ttaagttctg aaggaaaaca atttgctatc actgagttgg aacatccatt
     5521 atttaatgtg ataacaaacg caacgataaa taatgtgaat tttgaaaatg tagagataga
     5581 acgttctggt caagataata ttgcatcatt agccaatact atgaaaggtt cttcagttat
     5641 tacaaatgtc aaaattacag gcacactttc aggtcgtaat aatgttgctg gatttgtaaa
     5701 taatatgaat gatggaactc gtattgaaaa tgttgctttc tttggcaaac tacactctac
     5761 aagtggaaat ggctctcata cagggggaat tgcaggtaca aactatagag gaattgttag
     5821 aaaagcatat gttgatgcta ctattacagg aaacaaaaca cgcgccagct tgttagttcc
     5881 taaagtagat tatggattaa ctctagacca tcttattggt acaaaagctc tcctaactga
     5941 gtcggttgta aaaggtaaaa tagatgtttc aaatccagta gaagttggag caatagcaag
     6001 taagacttgg cctgtaggta cggtaagtaa ttctgtcagc tatgctaaga ttatccgtgg
     6061 agaggagtta ttcggctcta acgacgttga tgattctgat tatgctagtg ctcatataaa
     6121 agatttatat gcggtagagg gatattcgtc aggtaataga tcatttagga aatctaaaac
     6181 atttactaaa ttaactaaag aacaagctga tgctaaagtt actactttca atattactgc
     6241 tgataaatta gaaagtgatc tatctcctct tgcaaaactt aatgaagaaa aagcctattc
     6301 tagtattcaa gattataacg ctgaatataa ccaagcctat aaaaatcttg aaaaattaat
     6361 accattctac aataaagatt atattgtata tcaaggtaat aaattaaata aagaacacca
     6421 tctaaatact aaagaagttc tttctgttac cgcgatgaac aacaatgagt ttatcacaaa
     6481 cctagatgaa gctaataaaa ttattgttca ctatgcggac ggtacaaaag attactttaa
     6541 cttgtcttct agcagtgaag gtttaagtaa tgtaaaagaa tatactataa ctgacttagg
     6601 aattaaatat acacctaata tcgttcaaaa agataacact actcttgtta atgatataaa
     6661 atctatttta gaatcagtag agcttcagtc tcaaacgatg tatcagcatc taaatcgatt
     6721 aggtgactat agagttaatg caatcaaaga tttatattta gaagaaagct tcacagatgt
     6781 taaagaaaac ttaacaaacc taatcacaaa attagttcaa aacgaagaac atcaactaaa
     6841 tgattctcca gctgctcgtc aaatgattcg tgataaagtc gagaaaaaca aagcagcttt
     6901 attactaggt ttaacttacc taaatcgtta ctatggagtt aaatttggtg atgttaatat
     6961 taaagaatta atgctattca aaccagattt ctatggtgaa aaagttagcg tattagacag
     7021 attaattgaa atcggttcta aagagaacaa cattaaaggt tcacgtacat tcgacgcatt
     7081 cggtcaagta ttggctaaat atactaaatc aggtaattta gatgcatttt taaattataa
     7141 tagacaattg ttcacaaata tagacaatat gaacgattgg tttattgatg ctacagaaga
     7201 ccatgtctac atcgcagaac gcgcttctga ggtcgaagaa attaaaaatt ctaaacatcg
     7261 tgcattcgat aatttaaaac gaagtcacct tagaaatact atactcccac tactgaatat
     7321 tgataaagca catctttatt taatttcaaa ttataatgca attgcctttg gtagtgcaga
     7381 gcgattaggt aaaaaatcat tagaagatat taaagatatc gttaacaaag ctgcagatgg
     7441 ttatagaaac tattatgatt tctggtatcg tctagcgtct gataacgtta aacaacgact
     7501 actaagagat gctgttattc ctatttggga aggttataac gctcctggtg gatgggttga
     7561 aaaatatggc cgctataata ccgacaaagt atatactcct cttagagaat tctttggtcc
     7621 tatggataag tattataatt ataatggaac aggagcttat gctgctatat atcctaactc
     7681 tgatgatatt agaactgatg taaaatatgt tcatttagaa atggttggtg aatacggtat
     7741 ttcagtttac acacatgaaa caacacacgt caacgaccgt gcgatttact taggtggctt
     7801 tggacaccgt gaaggtactg atgctgaagc atatgctcag ggtatgctac aaactcctgt
     7861 tactggtagt ggatttgatg agtttggttc tttaggtatt aatatggtat ttaaacgcaa
     7921 aaatgatggg aatcagtggt atattacaga tccaaaaact ctaaaaacac gagaagatat
     7981 taatagatat atgaagggtt ataatgacac tttaactctt cttgatgaaa ttgaggctga
     8041 atctgtgatt tctcaacaaa ataaagattt aaatagtgca tggttcaaaa aaatagatag
     8101 agaataccgt gataacaata aattaaatca atgggataaa attcgaaatc taagtcaaga
     8161 agagaaaaat gaattaaata ttcaatctgt taatgattta gttgatcaac aattaatgac
     8221 taatcgcaat ccaggtaatg gtatctataa acccgaagca attagctata acgatcaatc
     8281 accttatgta ggtgttagaa tgatgaccgg tatctacgga ggtaatacta gtaaaggtgc
     8341 tcctggagct gtttcattca aacataatgc ttttagatta tggggttact acggatacga
     8401 aaatgggttc ttaggttatg cttcaaataa atataaacaa caatctaaaa cagatggtga
     8461 gtctgttcta agtgatgaat atattatcaa gaaaatatct aacaatacat ttaatactat
     8521 tgaagaattt aaaaaagctt acttcaaaga agttaaagat aaagcaacga aaggattaac
     8581 aacattcgaa gtaaatggtt cttccgtttc atcatacgat gatttactga cattgtttaa
     8641 agaagctgtt aaaaaagatg ccgaaactct taaacaagaa gcaaacggta ataaaacagt
     8701 atctatgaat aatacagtta aattaaaaga agctgtttat aagaaacttc ttcaacaaac
     8761 agatagcttt aaaacttcaa tctttaaata attgaaatct ctcatctgct ttgcggatga
     8821 gggttttctt attttatgct atacttaaag tatgcataga aaaacagtga ttgattttag
     8881 gactttgggg gagagatata cctttaccca gcctattaaa gagttgaaaa cgagaaatgt
     8941 agaagaagtg gcagattttc tggcacaagt ggaaagctac caagagcaag gttattatgt
     9001 ggtggggtat gtcagctacg aggctgcacc tgcttttgag gaaaaattag cagttcacaa
     9061 ggatccccta ctgggagagt acctgcttta ctttactgtt catgatagcg tagaaacttc
     9121 ccctattcct ctgacttatg aggatattga tttgccctca aattggcagg aagtgacgtc
     9181 tgcagcagac tatgaaaagg ccattgccca gatacaccat cacttgaggc agggagacac
     9241 ctatcaggtc aactacaccg tccaactcaa gcaaaagtta agtgccaatc cttttgccat
     9301 ctacaatcgt atggtggtag agcaggaggc gggctacaat gcctatgtgg aacatgacga
     9361 gatggcagtg atttccatga gcccagagct cttttttgag caaaatgatc gcgagttgac
     9421 aacacgacca atgaagggga cgactcagcg tggggtaact gaccaagaag atcttgaaca
     9481 ggccagttgg ttggaacagg atcccaaaaa tcgctctgaa aatatgatga ttgtggacct
     9541 cttgcgcaat gatatgaacc gtatttctga agttgggagc gagcacgtgg agcgtctgtg
     9601 ccaggtagag cagtattcaa ctgtttggca gatgacttcg accatcaaga gtcagttgcg
     9661 agaggatgtg gaccttgttg aaatcttccg ctcactcttt ccttgtggtt ccataacggg
     9721 tgcaccgaaa attgcgacaa tggagattat caaggacttg gagcctcaac cgcgtggagt
     9781 ctactgtgga acgattggtc tcttgcttcc aaatggacga cggattttta atgtggccat
     9841 tcgtaccatt caacttcaca aaggtcaagc catttatgga gttggcggag ggattacttg
     9901 ggatagcaca tgggaatctg aataccgaga ggttcatcaa aaggcagcag ttctttatcg
     9961 taaacaagct cgcttccaac tgattacgac aggggaaatc agccagaaga acctgctgtt
    10021 tgaagatcaa catctggaaa gactgagaaa agctagtcgt tattttgctt ttccttttga
    10081 tgcagaagac ttgggacaca agattgagga agagtgtcag gattgtgaag ctaatcgaga
    10141 ttaccgcttg cgaatcagcc ttagcaaatc tggagagata gaagtcaatc gtcaagtatt
    10201 aacccctctc agtacaagct tttgtcaggc ccaagtctgc cttcaggaag ctgctttgaa
    10261 tcaatccttt acctacttta aaaccactca ccgaccgcat ttgagcctag gagaacaaga
    10321 gaagatttac cacaataagt caggagaact gcttgaaacc tctataggaa atttggttct
    10381 gaaaatcgct ggaaaactct acacaccgcc tatccgactt ggaatcttgc caggaattta
    10441 ccgtcagtat ttgctagaaa caggacaggt agaagagaaa gtcttgacct tggcagattt
    10501 agcccaagca gaagctattt acggctgtaa tgcagtgaga ggcttgtatg aactaatcct
    10561 tgaggagaac tagatgaaac tgatattttt gcatgggtta gggcagtcag cagagtcttg
    10621 gaaagaagtt cggaatctac tgacagatta tccttctgag gctatcgagt tatttccttc
    10681 tggagttagt aactatcaac aagctaagga gcgagtttat cagcacctag ctcaagagac
    10741 agaacctttt gttttgattg gattgtcctt aggtgctgcc ctggcactag aactttccag
    10801 ttacgattta ccaaatcttc gagctttgat tctgtcagga tgcccgctta aattagcagg
    10861 gaatatccta ttttatcttc agttgctgat ttttaaacta cttcccaaaa gagtatttga
    10921 aaaacaggga gcagacaagg ctcttatggt cggagtttct gaggagttga agacacttga
    10981 tttaacggat atagcaggaa cttgccctta tccaacctta ctaatttgtg gtatcaaaga
    11041 taaaccgaat cttagttcta tgagaagtct tcataaacta atatcagaat cccaatttca
    11101 gattatccca gatggccctc atgtcttgaa taaggcaaaa ccaaaggagt ttgtagaaaa
    11161 gaccagaagt tttcttgaat tgctgaaata agtttgataa aataatattg aaatcgatat
    11221 cataattatg ggagaaagaa atgaataaac gtctattttt aaaaatgagt ctggtgacgt
    11281 tgccaatttt agccttgttt tcacaacctg tgttagcaga ggaaaacatt catttttcga
    11341 gttgtaagga agcttgggct aatggatatt cggatcttca tgagggagaa cctggttatt
    11401 ctgccaagtt agaccgcgat catgatggtg tggcttgcga attgaaaaat gctcctaagg
    11461 gtgcttttaa agcaaaacaa gcggctacaa ctcaaactga tacaacttca tccacagcaa
    11521 gtggttgggt taagcaggac ggttcttggt actattttga tggaaatgga aatctagtga
    11581 aaaatgcatg gcagggaaat tattacctga aagctgatgg taaaatggca cagagtgaat
    11641 ggatttatga ctcttcttat caagcttggt attatttgac atcagatggt tcttatgctt
    11701 acagtacatg gcaaggaaat tactatctaa aatcggatgg taaaatggct gtcaatgaat
    11761 gggttgatgg tggacgttat tatgttggcg ctgacggagt ttggaaggaa ggtcaagcaa
    11821 gtacagcttc ttctagtaat gatagcaata gtgaatattc tgctgcttta ggaaaggcaa
    11881 aaagttataa ttcgttattc cacatgtcaa aaaaacgtat gtatagacaa ttaacttctg
    11941 attttgataa attttcaaat gatgcagctc aatatgccat tgatcattta gatgattaac
    12001 agatactggt aggcgaaaaa attccttata attcatttac gcaaaccttt gcataagtga
    12061 atgtattttg atatactagt actgtaagca ttttcaatta ctacacaatg aaaaaggaga
    12121 atatgatgag tcaaaagatt attgggattg accttggtgg aacttctatc aaatttgcaa
    12181 tcttaacaac agcaggagaa atccaaggaa aatggtcaat caagaccaac attttggatg
    12241 agggaagtca tatcgttgat gatatgattg agtctattca acatcgtttg gacttgcttg
    12301 gattggcagc agcggacttc caaggcattg gaatgggatc accaggtgtg gttgaccgtg
    12361 acaaagggac tgttatcggt gcctacaact tgaactggaa aacccttcaa ccaatcaaac
    12421 aaaagattga aaaagctttg ggcattccat ttttcatcga taatgatgcc aacgtagcag
    12481 ctcttggtga gcgctggatg ggtgctggaa ataaccaacc agacgttgtc tttatgacac
    12541 tcggtactgg tgttggtggt ggtattgtcg cagaaggcaa attgcttcac ggtgttgctg
    12601 gtgcagcagg tgagcttggt catatcactg ttgattttga ccaaccaatt gcatgtactt
    12661 gtggtaaaaa aggctgcctt gagacagttg cttcagcaac agggattgtc aacttgactc
    12721 gtcgctatgc cgatgaatac gaaggcgatg cagccttgaa acgcttgatt gataatggag
    12781 aagaagtaac tgctaagact gtctttgatc tcgcaaaaga aggagacgac cttgctttga
    12841 ttgtttaccg taacttctca cgttacttgg gaatcgcttg tgctaacatt ggttcaatcc
    12901 taaacccatc aacaatcgtc atcggtggtg gtgtgtcagc tgcgggagaa ttccttctac
    12961 aaggtgttca aaaagtttac gatgaaaata gtttcccaca agtacgcaca tctactaaat
    13021 tagctcttgc aactctagga aatgacgctg gagttatcgg agcagcatca cttgtattgc
    13081 aataagataa tgagagagga aaatgctaac ctagagttag taatgttcct cttttatttt
    13141 ttatgctata ctagttagga caatgaatga ggtgagagta aatgacaaaa gcagatacga
    13201 tttttaaaga gaatattgaa cgcattctaa aggaaggtgt tttctcagag caggctcgtc
    13261 ctaagtacaa ggatgggact gttgctaatt ccaagtatgt aactggtgcc ttttccgagt
    13321 acgacttatc taaaggagaa tttcctatca caaccttgcg tcccattgca atcaaatccg
    13381 ccatcaaaga agttctctgg atttaccaag accagtcaaa tagcttagaa gtgcttaatg
    13441 acaagtacaa tgttcactac tggaatgact gggaagttgg agacacggga accattggtg
    13501 agcgctatgg tgccgttgtt aagaaacacg acattatcaa taagcttctc aaacagttgg
    13561 aaaccaatcc ttggaaccgc cgcaatatta tttcgctctg ggattaccaa gctttcgaag
    13621 aaacagatgg gctgctcccg tgcgcctttc agaccatgtt tgatgtccgg cgtgttgatg
    13681 gggaaatcta tctggatgcg accttgaccc agcgctccaa tgatatgctg gtggcccacc
    13741 acatcaacgc tatgcagtat gtggctttgc agatgatgat tgccaaacat tttggctgga
    13801 aggttgggaa gttcttctac ttcatcaaca acctccatat ctatgataat caatttgaac
    13861 aagctcagga attgctccgt cgggagccgt caaactgcca accacgcttg gttttaaatg
    13921 ttcctgatgg gactaatttc tttgatatca aagcagaaga ttttgagttg gtggattatg
    13981 accctgttaa gccacagttg aagtttgacc tagctattta aaagaataga aaaaagaagt
    14041 tgagaataat cccaacttct tttgtttctt aacgtgatac gcggcgacga gctgcttttt
    14101 tacggttttc ttcgatgaaa gctgcttttt gctcttctgg ttcgattact ttctttttaa
    14161 atgcgtatac tgcacctgca acggcagcga cagttcctgc gacacctgtt acaagacctt
    14221 tagcgaatcc tttagccatg agtcttcctc ctttatattc tcaatcagcc agcctcctca
    14281 agaggtcaca tttttctgac tgaccttttt gtgttataat aatagtaacg aaaaaatggg
    14341 aatttttcaa ggaaaaaaga tgaaaacaaa aataattgtg attgttggac cgactgctgt
    14401 tggaaagacg gctctagcta ttgaagttgc aaagcgtttt aatggcgaag tggttagtgg
    14461 agatagccag caagtctatc gaggacttga tattgggacg gccaaggcta gtccagaaga
    14521 gcaggcagct gttcctcatc atttaatcga tgttagagag ataaccgagt cttactcggc
    14581 ttttgatttt gtttcagaag ctaagatgac tattgaggat attcacagcc gtggcaagct
    14641 agccattatc gccggtggga ctggacttta tatccagagc ttgctagaag gttaccacct
    14701 aggtggggag actcctcatg aggagatttt agcttatcga gctagtttgg agccatattc
    14761 agatgaggaa ttagcccatt tggtggagca agcaggcctt gagattcccc agtttaatcg
    14821 tcgtcgtgct atgcgtgcct tagaaattgc ccattttggt caggatttgg aaaatcaaga
    14881 gaccttgtat gaaccgctga ttatctgctt ggatgatgaa cgtagtcaac tttatgagcg
    14941 tatcaaccac cgagtggatt tgatgtttga ggctgggctt ttggatgagg ccaagtggct
    15001 gtttgaccat tcccctaatg tacaggctgc taaaggaatt ggctataagg aactctttcc
    15061 ttatttccgt ggagagcaga ccttggagga agctagtgag agtctcaaac aggctactcg
    15121 tcgttttgcc aagcgtcagc tgacctggtt ccgtaatcgc atgcaggtca ccttttatca
    15181 gattggagaa tctggtgtac aagaccgcat tttaagccag atagaggagt ttttagatga
    15241 ttgaaacgga gaaaaaagag gagcgagtcc tgctgattgg tgtggaattg cagggtatgg
    15301 acagttttga cctctccatg gaagaattgg ctagtttagc gaaaacggca ggggcagtcg
    15361 ttgtagataa ctacagacaa aaacgtgaaa aatatgattc caagaccttc gtcggctctg
    15421 gtaagttgga agagattgcg cttatggtgg atgcagaaga aatcactact gtcatcgtca
    15481 acaaccgtct gacaccaagg cagaatgtca atctagagga agttctcggt gttaaggtca
    15541 ttgaccgtat gcagttgatt ttggatatct ttgccatgcg ggctcgaagc catgaaggga
    15601 agctccaagt ccacctagcc caactcaaat acctcttgcc tcgcttggtt ggtcagggga
    15661 ttatgctcag ccgtcaggca gggggaattg gttcccgtgg tcctggtgaa agccaactgg
    15721 agctgaaccg tcgtagcgtt cgcaatcaaa tcacggatat cgagcgccag ctcaaggtgg
    15781 ttgagaaaaa tcgggcgact gtcagagaaa aacgtttgga gtctagcacc tttaagattg
    15841 gtttgattgg ttataccaat gctgggaaat caactatcat gaacatcttg accagtaaga
    15901 cccagtatga agcagatgag ctctttgcga ctctggatgc gacaaccaag agtattcatc
    15961 tgggaggcaa tctccaagta actttgacag ataccgttgg ctttatccaa gatttgccga
    16021 cagagttggt gtccagtttc aagtcaacct tggaagaaag caagcatgtg gaccttctgg
    16081 ttcatgttat cgatgctagc aatccttatc acgaggagca tgaaaaaacg gttctctcca
    16141 tcatgaaaga cctggacatg gaagatattc ctcacttgac gctttataat aaagcggatt
    16201 tggtggagga tttcacgcct acccaaacgc catataccct catttctgcc aagtctgagg
    16261 acagtcgtga aaacttgcaa gcattattgc tagataagat taaggaaatt tttgaagcat
    16321 ttaccctgcg agtgcctttt tcaaagtcct acaagattca tgatttagag agtgttgcaa
    16381 ttctggaaga acgtgattat caggaagaca gcgaagtgat tacaggctac atttccgaaa
    16441 aaaataaatg gaggttagaa gaattttatg actgatatta aagctttggc tctaaagtat
    16501 ggaggttata caagtctgga caaggtctat ctggatcagc ttctagctgg taaaacagag
    16561 caggagcagt taacacttat tacacctccg ccaagtgttg ttaatgccta ctttgcagaa
    16621 ctctatcaga aaaagagtcc tcaggctgcg acggattatt ttgcagaact cagtcaggaa
    16681 ctgaatcttt acaatactga gccaagtttc accctagaaa ataagccttt tattcggctt
    16741 aatctgtctg gtaaatcctt tggtttttgt tatgatagtg acggccttgg tcggattttc
    16801 tctgaaaatg aggagaaaat ctcggatgac ttgctctttg aaattgcgca aattttcccc
    16861 catcaattag tctttgaaga gtctggtaag atttacatga agcctgtcga ggacgaggaa
    16921 gttgtcagcc tagaaagtct cacagctttg actgatttgg aaagattggc tgatggtcga
    16981 aaacgtctca aaggctacag ccaagaggat ttattgcaag aagctgctgc tttttctggc
    17041 aaacgctatt tccgatcgga aaaccgcaca gccatgttat atattgatta attagaaagt
    17101 atcgaatgga tattcaattt ttaggaacgg gggctggtca gccctctaaa gctcgcaacg
    17161 tttcaagtct cgccctgaaa cttttggatg agattaacga agtttggctc tttgactgtg
    17221 gagaaggtac gcaaaatcgc attctggaaa ccacaattcg accacgtaag atcagcaaaa
    17281 tctttattac ccatctgcat ggagaccaca tttttggttt gccaggtttc ctttctagcc
    17341 gtgcctttca ggccaatgaa gagcagacag atttggaaat ctacggacct caaggaatca
    17401 agtcatttgt cttaaccagc cttcgtgtgt caggttctcg tctgccctac cgcattcatt
    17461 tccatgagtt tgaccaagat tctctgggta aaattcttga aaccgataaa ttcactgtgt
    17521 atgcagagga gctggatcac actattttct gtgttggcta tcgtgtcatg caaaaagatc
    17581 tagaagggac gctggatgct gaaaaactca aggctgctgg tgttccgttc ggcccgcttt
    17641 ttggtaaaat caaaaacggc caggatcttg ttttggaaga cggaactgaa atcaaggcag
    17701 cagactatat ctcagcgcca cgtccaggta agattatcac tattttagga gacactcgaa
    17761 aaacggatgc cagtgtgcgt ctggctgtca atgcagatgt cctagttcat gagtccactt
    17821 atggcaaggg tgatgaaaaa attgctcgta accatggtca ctcaactaat atgcaagctg
    17881 cacaagtagc ggtagaagca ggtgccaaac gcctcctact caaccatatc agtgcccgtt
    17941 tcctctcaaa agatattagc aaactcaaga aagacgctgc cacaattttt gaaaatgtcc
    18001 atgtggtcaa agacttggaa gaagtggaaa tctagcagtc acagaaagga taagtatgcc
    18061 tactattctc attaccggag ctagcggtgg tctagctcaa gaaatggtca aactcctgcc
    18121 caatgaccaa ctcatcttgc ttggtagaaa taaggaaaaa ttagcccaac tctacggaaa
    18181 ttattcccat gcagaattga ttgaaattga tattaccgac gattcagccc tagaagctct
    18241 ggtaactgat ctttatctcc gctatggcaa gattgatgtc ttgattaaca acgctggtta
    18301 cgggattttt gagggatttg accagattgc tgataaagat attcaccaga tgtttgaggt
    18361 caataccttt gccctgatga atctgtctcg tcaccttgcg gctcgtatga aggaaagcag
    18421 caaagggcat atcatcaaca tcgtcagcat ggcaggtcta atagctactg gcaagtctag
    18481 tctttactca gcgaccaagt ttgcggctat tggtttttca aatgctctgc gactcgaact
    18541 tatgccctat ggagtctatg tgacaacagt caatccaggt ccaatccgaa caggattttt
    18601 tgaccaagct gacccagatg gaacttatct taaatcggtt gaccgcttcc tcttagaggc
    18661 agatgcagtg gctaaaaaga ttgtcaagat tataggcaaa aataaacgag aactcaatct
    18721 cccgattttg ttgaacctag cccataagtt ttatactctc tttcccaagc tagctgataa
    18781 gttggtaggg gaaactttta attataagta aaaag
//
LOCUS       DAVLHC010000037        18665 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.037, whole genome shotgun sequence.
ACCESSION   DAVLHC010000037 DAVLHC010000000
VERSION     DAVLHC010000037.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 18665)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18665)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18665
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.037"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(282..1088)
                     /gene="yidA"
                     /locus_tag="VXE25_001537"
     CDS             complement(282..1088)
                     /gene="yidA"
                     /locus_tag="VXE25_001537"
                     /EC_number="3.1.3.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000023490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar-phosphatase"
                     /protein_id="HEV0771977.1"
                     /translation="MSIKLIAVDIDGTLVNSQKEITPEVFSAIQDAKEAGVKVVIATG
                     RPIAGVAKLLDDLQLRDQGDYVVTFNGALVQETATGHEIISESLTYEDYLDMEFLSRK
                     LGVHMHAITKDGIYTANRNIGKYTVHESTLVSMPIFYRTPEEMAGKEIVKCMFIDEPE
                     ILDAAIEKIPAEFYERYSINKSAPFYLELLTKNVDKGSAITHLAEKLGLTKDETMAIG
                     DEENDRAMLEVVGNPVVMENGNPEIKKIAKYITKTNDESGVAHAIRTWVL"
     gene            complement(1101..2405)
                     /locus_tag="VXE25_001538"
     CDS             complement(1101..2405)
                     /locus_tag="VXE25_001538"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001003495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HD domain-containing protein"
                     /protein_id="HEV0771978.1"
                     /translation="MNEKVFRDPVHNYIHVNNQIIYDLINTKEFQRLRRIKQLGTSSY
                     TFHGGEHSRFSHCLGVYEIARRITEIFEEKYPEEWNPAESLLTMTAALLHDLGHGAYS
                     HTFENLFDTDHEAITQEIIQNPETEIHQVLLQVAPDFPEKVASVIDHTYPNKQVVQLI
                     SSQIDADRMDYLLRDSYFTGASYGEFDLTRILRVIRPIENGIAFQRNGMHAIEDYVLS
                     RYQMYMQVYFHPATRAMEVLLQNLLKRAKELYPEDKDFFARTSPHLLPFFEKNVTLTD
                     YLALDDGVMNTYFQLWMTSPDKILADLSQRFVNRKVFKSITFSQEDQDQLASMRKLAE
                     DIGFDPDYYTAIHKNFDLPYDIYRPESENPRTQIEILQKNGELAELSSLSLIVQSLAG
                     SRHGDNRFYFPKEMLDQNSIFASITQQFLHLIENDHFTPNKN"
     gene            2477..2854
                     /locus_tag="VXE25_001539"
     CDS             2477..2854
                     /locus_tag="VXE25_001539"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701643.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1934 domain-containing protein"
                     /protein_id="HEV0771979.1"
                     /translation="MKIRMRNTIQFDEQLEVIDRLYDVEVHEKGDYSYLLFYNEEKEK
                     VVIKFHGQELVMSRFSNPKTIMRFLKDSDSLAYIPTPMGMQEFIIQTSHYQVDRQKIE
                     LDYQLQNQEGHPFASYQLEITWG"
     gene            2945..3277
                     /locus_tag="VXE25_001540"
     CDS             2945..3277
                     /locus_tag="VXE25_001540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009660419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative DNA-binding protein"
                     /protein_id="HEV0771980.1"
                     /translation="MEIEKTNRMNALFEFYAALLTDKQMNYIELYYADDYSLAEIAEE
                     FGVSRQAVYDNIKRTEKILEDYEMKLHMYSDYIVRSQIFDQILERYPKDDFLQEQIEI
                     LTSIDNRE"
     gene            3289..4860
                     /gene="ffh"
                     /locus_tag="VXE25_001541"
     CDS             3289..4860
                     /gene="ffh"
                     /locus_tag="VXE25_001541"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000863601.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal recognition particle protein"
                     /protein_id="HEV0771981.1"
                     /translation="MAFESLTERLQNVFKNLRKKGKISESDVQEATKEIRLALLEADV
                     ALPVVKDFIKKVRERAVGHEVIDTLNPAQQIIKIVDEELTAVLGSDTAEIIKSPKIPT
                     IIMMVGLQGAGKTTFAGKLANKLKKEENARPLMIAADIYRPAAIDQLKTLGQQIDVPV
                     FALGTEVPAVEIVRQGLEQAQTNHNDYVLIDTAGRLQIDELLMNELRDVKALAQPNEI
                     LLVVDAMIGQEAANVAREFNAQLEVTGVILTKIDGDTRGGAALSVCHITGKPIKFTGT
                     GEKITDIETFHPDRMSSRILGMGDMLTLIEKASQEYDEQKALEMAEKMRENTFDFNDF
                     IDQLDQVQNMGPMEDLLKMIPGMANNPALQNMKVDERQIARKRAIVSSMTPEERENPD
                     LLNPSRRRRIAAGSGNTFVEVNKFIKDFNQAKQLMQGVMSGDMNKMMKQMGINPNNLP
                     KNMPNMGGMDMSALEGMMGQGGMPDLSALGGAGMPDMSQMFGGGLKGKIGEFAMKQSM
                     KRMANKMKKAKKKRK"
     gene            complement(5055..6338)
                     /locus_tag="VXE25_001542"
     CDS             complement(5055..6338)
                     /locus_tag="VXE25_001542"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007554578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil permease"
                     /protein_id="HEV0771982.1"
                     /translation="MKQESTVDLLLDVDQRPSDGKGILLSFQHVFAMFGATILVPLIL
                     GMPVSVALFASGVGTLIYMIATGFKVPVYLGSSFAFITAMSLAMKEMGGDVSAAQTGV
                     ILTGLVYVLVATSIRFVGTKWIDKLLPPIIIGPMIIVIGLGLAGSAVTNAGLVADGNW
                     KNALVAVVTFLIAAFINTKGKGFLRIIPFLFAIIGGYLFALTLGLVDFTPVLEANWFE
                     IPGFYLPFSTGGAFKEYNLYFGPEAIAILPIAIVTISEHIGDHTVLGQICGRQFLKEP
                     GLHRTLLGDGIATSVSAFLGGPANTTYGENTGVIGMTRIASVSVIRNAAFIAIALSFL
                     GKFTALISTIPNAVLGGMSILLYGVIASNGLKVLIKERVDFAQMRNLIIASAMLVLGL
                     GGAILKLGPVTLSGTALSAMTGIILNLILPYENKD"
     gene            complement(6592..7305)
                     /gene="rsmG"
                     /locus_tag="VXE25_001543"
     CDS             complement(6592..7305)
                     /gene="rsmG"
                     /locus_tag="VXE25_001543"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (guanine(527)-N(7))-methyltransferase
                     RsmG"
                     /protein_id="HEV0771983.1"
                     /translation="MKPETFYNLLAEQNLPLSDQQKEQFERYFELLVEWNEKINLTAI
                     TDKEEVYLKHFYDSIAPILQGLIPNETIKLLDIGAGAGFPSLPMKILYPELDVTIIDS
                     LNKRINFLQLLAQELDLNGVHFYHGRAEDFAQDKNFRAQYDFVTARAVARMQVLSELT
                     IPYLKVGGKLLALKASNAPEELLEAKNALNLLFSKVEDNLSYALPNRDPRYITVVEKK
                     KETPNKYPRKAGMPNKRPL"
     gene            7399..7959
                     /locus_tag="VXE25_001544"
     CDS             7399..7959
                     /locus_tag="VXE25_001544"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000219838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LemA family protein"
                     /protein_id="HEV0771984.1"
                     /translation="MTWIILGVIALIVIFVIVSYNGLVKNRMQTKEAWSQIDVQLKRR
                     NDLLPNLIETVKGYAKYEGSTLEKVAELRNQVAAATSPAEAMKASDALTRQVSGIFAV
                     AESYPDLKASANFVKLQEELTNTENKISYSRQLYNSVVSNYNVKLETFPSNIIAGMFG
                     FKAADFLQTPEEEKSVPKVDFSGLGD"
     gene            7961..8860
                     /gene="htpX"
                     /locus_tag="VXE25_001545"
     CDS             7961..8860
                     /gene="htpX"
                     /locus_tag="VXE25_001545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc metalloprotease HtpX"
                     /protein_id="HEV0771985.1"
                     /translation="MLFDQIASNKRKTWILLLVFFLLLALVGYAVGYLFIRSGLGGLV
                     IALIIGFIYALSMIFQSTEIVMSMNGAREVDEQTAPDLYHVVEDMALVAQIPMPRVFI
                     IDDPALNAFATGSNPQNAAVAATSGLLAIMNREELEAVMGHEVSHIRNYDIRISTIAV
                     ALASAITMLSSMAGRMMWWGGAGRRRSDDDRDGNGLEIIMLVVSLLAIVLAPLAATLV
                     QLAISRQREFLADASSVELTRNPQGMINALDKLDNSKPMSRHVDDASSALYINDPKKG
                     GGFQKLFYTHPPISERIERLKQM"
     gene            complement(8904..10463)
                     /locus_tag="VXE25_001546"
     CDS             complement(8904..10463)
                     /locus_tag="VXE25_001546"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011681787.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HEV0771986.1"
                     /translation="MHYEHSRKGNHMIKINHLTITQNKDLRDLVSDLTMTIQDGEKVA
                     IIGEEGNGKSTLLKILMGEALSDFTIKGNIQSDYQSLAYIPQKVPEDLKKKTLHDYFF
                     LDSIDLDYSILYRLAEELHFDSNRFASDQEIGNLSGGEALKIQLIHELAKPFEILFLD
                     EPSNDLDLETVDWLKGQIQKTRQTVIFISHDEDFLSETADTIVHLRLVKHRKEAETLV
                     EHLDYDSYSEQRKANFAKQSQQAANNQRAYDKTMEKHRRVKQNVETALRATKDSTAGR
                     LLAKKMKTVLSQEKRYEKAAQSMTQKPLEEEQIQLFFSDIQPLPASKVLVQLEKENLS
                     IDDRVLVQKLQLTVRGQEKIGIIGPNGVGKSTLLAKLQRLLNDKREISLGFMPQDYHK
                     KLQLDLSPIAYLSKTGEKEELQKIQSHLASLNFSYPEMQHQIRSLSGGQQGKLLLLDL
                     VLRKPNFLLLDEPTRNFSPTSQPQIRKLFATYPGGLITVSHDRRLLKEVCSIIYRMTE
                     HGLKLVNLEDL"
     gene            complement(10702..11019)
                     /locus_tag="VXE25_001547"
     CDS             complement(10702..11019)
                     /locus_tag="VXE25_001547"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000389556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase BlpT"
                     /protein_id="HEV0771987.1"
                     /translation="MEDKKLIQLLSKLNKSYQNCKQGTADDIRLQELLNTTMQELKKT
                     EQLNNSILIDLEKFYQPTSLLIGLGSLKLNDQARTAWRNYDKFHYDHVKHVLSLYGPV
                     FEF"
     gene            11189..11731
                     /locus_tag="VXE25_001548"
     CDS             11189..11731
                     /locus_tag="VXE25_001548"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF177 domain-containing protein"
                     /protein_id="HEV0771988.1"
                     /translation="MKLNIQEIRKQSEGLNFEQTLDLVDDLRARNQEILDVKDILAVG
                     KVQYEDRMYFLDYQLSYTIVLASSRSMEPVELVESYPVTEVFMEGATNQLDQEVLDDD
                     LVLPIENGELDLAESVSDNILLNIPIKVLTAEEEAGQGFISGNDWQIMTEEEYQAQKA
                     VKKEENSPFAGLQGLFDGDE"
     gene            11731..12360
                     /gene="nth"
                     /locus_tag="VXE25_001549"
     CDS             11731..12360
                     /gene="nth"
                     /locus_tag="VXE25_001549"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000244461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease III"
                     /protein_id="HEV0771989.1"
                     /translation="MVLSKKRARKVLEEIIALFPDAKPSLDFTNHFELLVAVMLSAQT
                     TDAAVNKATPGLFVAFPTPQAMSVATESEIASHISRLGLYRNKAKFLKKCAQQLLDDF
                     DGQVPQTREELESLAGVGRKTANVVMSVGFGIPAFAVDTHVERICKHHDIVKKSATPL
                     EVEKRVMDILPPEQWLAAHQAMIYFGRAICHPKNPECDQYPQLYDFSNL"
     gene            12571..13092
                     /gene="pyrR"
                     /locus_tag="VXE25_001550"
     CDS             12571..13092
                     /gene="pyrR"
                     /locus_tag="VXE25_001550"
                     /EC_number="2.4.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000850024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional pyr operon transcriptional
                     regulator/uracil phosphoribosyltransferase PyrR"
                     /protein_id="HEV0771990.1"
                     /translation="MKTKEVVDELTVKRAITRITYEIIERNKDLNKIVLAGIKTRGVF
                     IAHRIQERLKQLENLSVPVVELDTKPFRDDVKSGEDTSLVSVDVTDREVILVDDVLYT
                     GRTIRAAIDNIVGHGRPARVSLAVLVDRGHRELPIRPDYVGKNIPTSRSEEIIVEMTE
                     LDDQDRVLITEEA"
     gene            13111..14034
                     /locus_tag="VXE25_001551"
     CDS             13111..14034
                     /locus_tag="VXE25_001551"
                     /EC_number="2.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001293822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate carbamoyltransferase catalytic
                     subunit"
                     /protein_id="HEV0771991.1"
                     /translation="MSENQQALNHVVSMEDLTVDQVMKLIKRGIEFKNGAQLPYEDHP
                     IVSNLFFEDSTRTHKSFEVAEIKLGLERLDFDVKTSSVNKGETLYDTILTLSALGVDV
                     CVIRHPEVDYYRELIASPTITTSIINGGDGSGQHPSQSLLDLMTIYEEFGHFEGLKVA
                     IAGDLDHSRVAKSNMQILKRLGAELFFAGPEEWRSQEFADYGQFVTIDEIIDQVDVMM
                     FLRVQHERHDSGAVFSKEDYHAQHGLTQERYDRLKETAILMHPAPINRDVEIADHLVE
                     APKSRIVQQMTNGVFVRMAILESVLASRNAN"
     gene            14084..15163
                     /gene="carA"
                     /locus_tag="VXE25_001552"
     CDS             14084..15163
                     /gene="carA"
                     /locus_tag="VXE25_001552"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166701.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine-hydrolyzing carbamoyl-phosphate
                     synthase small subunit"
                     /protein_id="HEV0771992.1"
                     /translation="MTKRILVLEDGTVFEGKAFGADIDVTGEIVFNTGMTGYQESITD
                     QSYNGQILTFTYPLVGNYGINRDDYESIIPTCKGVVVFEEARRASNWRNQMTLDEFLK
                     AKKIPGISGIDTRALTKIIRKHGTMRATLTHVGDSMDHVTDQLQATVLPTDNIKQVST
                     KTSYPAPGVGLSVVLVDFGLKHSILRELSKRNCNVTVVPYSTTAEEILHLNPDGVMLS
                     NGPGNPEDVPQALDMIRGVQGKIPIFGICMGHQLFAMANGAKTYKMKFGHRGFNHAVR
                     EIATGRVDFTSQNHGYAVSREDLPEHLIITHEEINDKSVEGVRHRYQPAFSVQYHPDA
                     APGPHDASYLFDEFIEMMEVFKQSN"
     gene            15476..18652
                     /gene="carB"
                     /locus_tag="VXE25_001553"
     CDS             15476..18652
                     /gene="carB"
                     /locus_tag="VXE25_001553"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbamoyl-phosphate synthase large subunit"
                     /protein_id="HEV0771993.1"
                     /translation="MPKRTDIQKIMVIGSGPIIIGQAAEFDYAGTQACLSLKEEGYEV
                     VLVNSNPATIMTDKEIADKVYIEPITLEFVTRILRKEGPDALLPTLGGQTGLNMAMEL
                     SKNGILDELGVELLGTKLSAIDQAEDRDLFKQLMEELEQPIPESEIVNTVEEAVAFAA
                     TIGYPVIVRPAFTLGGTGGGMCANEKELREITENGLKLSPVTQCLIERSIAGFKEIEY
                     EVMRDSADNALVVCNMENFDPVGIHTGDSIVFAPAQTMSDYENQMLRDASLSIIRALK
                     IEGGCNVQLALDPNSFKYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEV
                     INPVTGSTYAMFEPALDYVVAKIPRFPFDKFEKGERRLGTQMKATGEVMAIGRNIEES
                     LLKACRSLEIGVHHNEIPELAAVSDDALIEKVVKAQDDRLFYVSEAIRRGYTPEEIAE
                     LTKIDIFYLDKLLHIFEIEQELGAHPQDLEVLKTAKLNGFSDRKIAELWGTTDDKVRQ
                     LRLENKIVPVYKMVDTCAAEFDSETPYFYSTYGWENESIRSDKESVLVLGSGPIRIGQ
                     GVEFDYATVHSVKAIQAAGYEAIIMNSNPETVSTDFSVSDKLYFEPLTFEDVMNVIDL
                     EQPKGVIVQFGGQTAINLAEPLAKAGVTILGTQVADLDRAEDRDLFEQALKELDIPQP
                     PGQTATNEEEAALAARKIGFPVLVRPSYVLGGRAMEIVENEEDLRSYMRTAVKASPDH
                     PVLVDSYIVGQECEVDAISDGKNVLIPGIMEHIERAGVHSGDSMAVYPPQTLSQKVQE
                     TIADYTKRLAIGLHCLGMMNIQFVIKDEKVYVIEVNPRASRTVPFLSKVTNIPMAQVA
                     TKLILGQSLSELGYQNGLYPESTRVHIKAPVFSFTKLAKVDSLLGPEMKSTGEVMGSD
                     ATLEKALYKAFEASYLHLPTFGNVVFTIADDAKEEALNLARRFQNIGYGILATEGTAA
                     FFASHGLQAQPVGKIGDDDKDIPSFVRKGRIQAIINTVGTKRTADEDGEQIRRSAIEH
                     GVPLFTALDTANAMLKVLESRSFVTEAI"
BASE COUNT         5421 a         3598 c         4203 g         5443 t
ORIGIN      
        1 aagtatccta atttgtataa ttgattgtgt gtagattcag ggtcaatttg aagagagtat
       61 ttaaaatatc ttgggaaatt ataatttctc cctgtttttt gagtccaatc tatgagtatg
      121 agttgcccag gagtaaggcc acattctaat tcgtttaggt aaaaattgtt acaatcagaa
      181 tttgtgtctc tattatgatt attttgtttt aaattaaata gtttgctaaa aaaattcatt
      241 ggattttatt gctaatcaat tcttattgaa aaatgatact tttacagtac ccatgttcgg
      301 atggcgtggg caacgccgga ttcgtcattt gttttagtga tgtatttggc gatttttttg
      361 atttctggat ttccattttc catgacaacg gggtttccaa cgacttccag catggcacgg
      421 tcattttctt cgtcaccgat tgccatggtt tcatctttgg tcaatccgag tttttcagcc
      481 aagtgagtaa tggctgaacc cttgtctaca ttctttgtaa ggagttcgag gtagaaagga
      541 gcagatttgt tgatggagta gcgctcgtaa aattctgctg gaattttttc aatcgcagca
      601 tcgagaattt ctggttcatc gataaacata catttaacaa tttctttgcc agccatttct
      661 tcaggggtac ggtagaagat aggcatgctg acgagggttg attcgtgtac agtgtatttt
      721 ccgatattgc gatttgcagt atagataccg tccttggtaa tggcatgcat gtggacaccg
      781 agcttgcgac tgaggaattc catatccaga taatcctcat aggtcaagga ttcgctgata
      841 atctcatggc cagtagcagt ttcttggaca agggcaccat tgaaggtcac cacatagtca
      901 ccttggtctc tcaactgcaa gtcgtccaga agtttggcaa cacctgcgat ggggcggcca
      961 gttgcaatca cgactttgac accagcttct ttggcatctt ggatggcaga aaagacttca
     1021 ggagtgattt ccttttggct gttgactagg gttccgtcaa tatcgacggc aattagttta
     1081 atactcataa atttcctctt ctagttttta tttggggtaa aatgatcgtt ctcaatcaag
     1141 tgtaaaaatt gctgggtaat gcttgcgaag atgctgtttt ggtctaacat ttctttaggg
     1201 aaatagaaac gattatctcc gtggcgactg ccagcaaggg attggacgat aagagacagg
     1261 ctagagagtt cggccagttc tccatttttt tgtaaaatct caatctgtgt ccgtgggttt
     1321 tcagattcgg gacgatagat atcataaggg aggtcaaagt tcttatgaat ggcagtgtag
     1381 tagtcgggat caaagccgat atcctcagct aattttctca tgctggcgag ttggtcttgg
     1441 tcctcttgtg aaaaggtaat ggatttaaag accttgcggt tgacaaagcg ttgtgacaag
     1501 tctgcgagaa tcttgtcagg actggtcatc cagagttgaa agtaggtatt catcacacca
     1561 tcatctagag ccagatagtc agtcaaggtc acattttttt caaagaaagg caggaggtgt
     1621 ggagaagttc gtgcaaagaa gtccttgtct tcaggataga gttccttggc gcgtttgaga
     1681 agattctgta ggagaacttc catggcgcgt gttgcggggt ggaaataaac ctgcatgtac
     1741 atctggtagc gactgaggac gtagtcttcg atggcgtgca tgccattgcg ctgaaaggcg
     1801 ataccatttt cgataggacg aatgactcgg aggattcgag tcaggtcaaa ttccccatag
     1861 gatgctcctg taaaatagga gtcacgcaag agatagtcca tgcggtccgc atcaatctgg
     1921 ctagaaatga gctgcacgac ctgcttatta ggataggtat ggtcaatgac actggccacc
     1981 ttttctggga aatcaggtgc cacttgtagc aggacttggt gaatctctgt ctcaggattt
     2041 tgaataatct cctgagtaat ggcttcatgg tctgtatcaa agagattttc aaaagtatgg
     2101 gagtaggcac catgcccaag gtcgtgtagg agagcagcgg tcatggtcaa gagagactcg
     2161 gcaggattcc attcctcagg atatttttct tcgaaaatct ctgtgatgcg tcgtgcaatt
     2221 tcatagactc ctagacagtg agagaagcgg ctgtgctctc caccgtggaa ggtataactg
     2281 gaggttccca gttgcttgat acggcgcaaa cgctgaaatt cttttgtatt aatcaagtca
     2341 tagataattt gattattgac atggatgtag ttgtgaactg ggtcacggaa tactttttcg
     2401 ttcatatgac cattatagca aaatcctgct ctttttggta aaatagtagg acaagagaca
     2461 agaaagaggg cctgatgtga agattcggat gcgaaataca attcagtttg atgagcagtt
     2521 ggaagtgatt gaccggcttt atgatgtgga agtgcatgaa aaaggagatt atagctacct
     2581 gcttttctat aatgaggaaa aggaaaaagt agtgattaaa tttcatggtc aagaacttgt
     2641 gatgagccga ttttctaatc ccaagaccat tatgcgcttt ctaaaggata gcgatagttt
     2701 agcctatatt cctacaccta tgggcatgca ggagtttatc atccaaacga gccattatca
     2761 agttgatagg caaaagattg aactagatta tcaactacaa aatcaagagg gacatccttt
     2821 tgccagctat caattggaaa ttacttgggg ctaggctcat gtctttttca aatttagcta
     2881 tctatcttct tggatcggct tcctagtgtg gtagattagg ctaatttttg gtataataaa
     2941 agttatggaa atcgaaaaaa ccaatcgtat gaatgcgctc tttgaatttt atgcggcgct
     3001 tttgacagat aagcaaatga attatatcga gctctactac gctgatgatt acagccttgc
     3061 tgaaattgcc gaggagtttg gtgtcagtcg tcaggctgtc tatgacaata tcaagcgaac
     3121 agaaaagatt ctggaagatt atgagatgaa attgcacatg tactcggact atattgtccg
     3181 cagtcagatt tttgatcaga ttttggagcg ctatcccaag gatgactttc tgcaggagca
     3241 gatagaaatt ttaacaagca ttgataatag agaataagag gaagaaaaat ggcatttgaa
     3301 agtttaacag aacgtttgca gaacgtcttt aaaaatctac gtaaaaaagg aaaaatctct
     3361 gaatctgatg tccaagaggc aaccaaagaa attcgcttgg ccttgctcga ggccgacgtt
     3421 gccttgcctg ttgtaaagga ctttatcaag aaagttcgcg agcgtgcagt cgggcatgag
     3481 gtcattgata cacttaatcc tgcgcaacag attattaaaa tcgttgatga ggaactgaca
     3541 gccgttttag gttctgatac ggcagaaatt atcaagtcac ctaagattcc aaccatcatc
     3601 atgatggttg gtttgcaggg agctggtaaa acaacttttg caggtaagct ggctaacaaa
     3661 ctcaagaagg aagaaaatgc ccgtcctttg atgattgcgg cggatattta ccgtcctgct
     3721 gccattgatc agctgaagac actgggacaa cagattgatg tgccggtttt cgctcttggg
     3781 acagaggttc cagctgttga gattgtacgt caaggtttgg agcaagctca aactaatcat
     3841 aacgactatg tcttgattga tactgcgggt cgtttgcaga ttgatgagct cctcatgaat
     3901 gagcttcgtg atgtgaaagc attggctcaa ccaaatgaaa tcttgcttgt cgttgatgct
     3961 atgattggtc aggaagcagc caatgttgcg cgtgagttta atgctcagtt ggaagtgact
     4021 ggggtcatcc ttaccaagat tgatggcgat actcgtggtg gtgctgctct gtctgtttgt
     4081 cacattactg gaaaaccaat caagttcact ggtacaggtg aaaagattac ggacattgaa
     4141 accttccacc cagaccgcat gtctagccgt atccttggca tgggggatat gctcactttg
     4201 attgagaaag cttctcagga atacgatgaa caaaaagccc ttgaaatggc tgagaagatg
     4261 cgcgaaaaca cctttgattt taatgatttc atcgatcaat tagatcaggt gcaaaatatg
     4321 gggccgatgg aagacttgct caagatgatt ccaggtatgg ccaacaatcc agcacttcaa
     4381 aacatgaagg tggatgaacg ccagattgct cgtaaacgtg cgattgtgtc ttcgatgaca
     4441 cctgaagaac gtgaaaaccc agatttgtta aatccaagcc gtcgccgtcg tattgctgct
     4501 ggttctggaa atacattcgt cgaagtcaat aaattcatca aggactttaa ccaggctaaa
     4561 cagctcatgc agggtgttat gtctggggat atgaataaaa tgatgaagca aatggggatt
     4621 aatccaaata accttcctaa aaatatgcca aatatgggag gaatggatat gtctgccctt
     4681 gaaggaatga tgggacaagg cggtatgcct gacttatcag ctctcggagg agcaggaatg
     4741 ccagatatga gccagatgtt tggtggcggt ttgaaaggta aaattggtga atttgccatg
     4801 aaacagtcca tgaaacgtat ggctaacaaa atgaagaaag cgaagaagaa acgcaagtaa
     4861 gacaagagat tgatgcaaat ctcatttgat gagaaaataa agtaaaaatt tctatgataa
     4921 aacgtacagt atcaaggttt tagaatatct gatattatac gttttttgat tttaataatt
     4981 ttgttaagac acttttatta tggtatacga aaaatccact cagctgtctg agtggattag
     5041 gtgtatttag actcttagtc tttattttcg tatggcaaga tcaagttcaa gatgattcct
     5101 gtcatggctg aaagggcagt acctgaaagt gtaactggac caagtttaag gatagctcct
     5161 ccaagtccaa gaaccaacat agcacttgcg atgatgaggt ttcgcatttg agcgaaatca
     5221 acacgttctt taatcaagac tttcaaacca ttgctggcga taaccccata gagaaggatt
     5281 gacataccac caagtacagc gtttggaata gttgaaatca aggcagtgaa tttaccaagg
     5341 aagctgaggg caatcgcgat gaaggcagcg ttacggataa ctgagacaga agcgatacga
     5401 gtcataccga taacccctgt attttctccg taagttgtat tggctggtcc accaaggaag
     5461 gcagaaacag aagttgcgat accgtcacca agaagagtac ggtgaagacc tggttctttt
     5521 aagaattgac gaccacagat ttgacccaaa acagtatggt ctccgatatg ttcagaaatt
     5581 gttacgatag cgattggcaa gatagcgatg gcttctggac caaagtaaag attgtactct
     5641 ttaaaggcac cacctgtgct aaatggcaag tagaaaccag gaatttcaaa ccagttagct
     5701 tctaggacag gtgtaaagtc aaccaagcca agagttagtg cgaaaaggta accaccgata
     5761 atggcaaaga ggaatggaat gattcgtagg aagccttttc cttttgtatt gataaaggca
     5821 gcaattagga aagtaacaac ggctaccaga gcatttttcc aatttccgtc tgctacaaga
     5881 cctgcattgg taacagctga acctgcaagt ccaagaccga taacgatgat cataggaccg
     5941 ataatgattg gtggcaagag tttatcaatc cattttgttc ctacaaatcg gatgctggta
     6001 gcaacaagga catagaccaa accagtcaag ataacccctg tttgggcagc agatacatcc
     6061 ccccccattt ctttcatagc cagtgacata gctgtgataa aggcaaatga agaacctaga
     6121 taaactggaa ctttaaaacc agtagcaatc atgtagatga gtgttccaac acctgaagca
     6181 aaaagggcaa cagatacagg cattcccaaa atcaatggta ccaagatggt cgcaccaaac
     6241 atggcgaaaa cgtgttggaa actaaggaga attccttttc catccgaagg acgttggtca
     6301 acgtctagta acaaatcaac agttgattct tgtttcatat aaacctcact tttgggcatc
     6361 agaaaagagc ccattatttt acagcaatag gccctcagag taagacttct ctaaaatcta
     6421 gactttaaag agtttcaaat atttctgcgt cttcgtcacc tcacgggatg acattaaaaa
     6481 cctttgctta ggatagtata gcagaaaaaa atgattttgt aaatcatttt ttcccgagcc
     6541 taaaaataag agagcgaggt tgattttgta aatatttttt tacttaaaaa tttaaagcgg
     6601 gcgtttattt ggcataccag ccttacgtgg atatttattt ggtgtttctt ttttcttttc
     6661 taccactgtg atgtaacgcg gatctctatt tggtagggcg tagctgagat tgtcttcgac
     6721 tttactaaaa aggagattga gggcattctt agcttctaac aactcctcag gcgcattgct
     6781 ggccttgagt gccaatagtt ttccaccaac cttaaggtag ggaatagtca attcagatag
     6841 gacctgcata cgggcaaccg cacgagctgt tacaaaatca tattgagcac ggaagttctt
     6901 gtcttgggca aaatcttcgg cacgtccgtg gtagaaatga actccgttca aatccagttc
     6961 ttgagccaag agttgtagga agttgatgcg cttattgagt gaatcaataa tggtcacatc
     7021 taactccgga tagagaattt tcattggtag actaggaaat cctgccccag ccccgatatc
     7081 aagaagtttg atagtttcat tgggaatcaa accttgaaga atgggtgcaa tcgaatcgta
     7141 aaaatgtttg agataaactt cttccttgtc cgtaatcgcc gtcaaattaa tcttctcatt
     7201 ccactcgacc aagagctcaa aataacgttc aaattgttct ttttgctggt ccgaaagtgg
     7261 aagattctgc tcggcaagca agttgtaaaa tgtttctggt ttcatagtta tttccttctt
     7321 tagtatcatc ttattttacc acaatcatta aaaatttgat atactggtac taatctaaaa
     7381 gtagaaagga cttatatcat gacttggatt attcttggag ttatcgctct tattgttatt
     7441 tttgtgattg ttagctataa cggtttggtt aaaaatcgta tgcaaaccaa ggaggcttgg
     7501 agtcagattg atgttcagtt gaaacgtcga aatgacctct tgccaaactt gattgagact
     7561 gtaaaaggtt atgccaaata tgaaggttct acccttgaaa aggtggcaga actacgtaac
     7621 caagtggcgg cagcgacttc accagcagaa gctatgaaag ccagtgatgc cctcactcgt
     7681 caagtttcag gtatttttgc agttgcagaa agctatccag atttgaaagc tagtgctaac
     7741 tttgttaaat tgcaagagga gttgacaaac acagaaaata aaatttctta ctctcgtcaa
     7801 ctctataaca gtgttgtcag caactacaat gtaaaattag aaactttccc gagcaatatt
     7861 atcgctggaa tgtttggatt taaagcggca gatttccttc aaacacctga agaggaaaag
     7921 tcggttccta aagttgattt tagcggttta ggtgactaag atgttgtttg atcaaattgc
     7981 aagcaataaa cgaaaaacct ggattttgtt gctggtattt ttcctactct tagctcttgt
     8041 tggttatgcg gttggttatc tctttataag atctggactt ggtggtttgg ttattgcact
     8101 gattatcggc tttatctacg ctttgtctat gatttttcaa tcgacagaga ttgtcatgtc
     8161 catgaatgga gcgcgtgagg tggatgagca aacggcacca gacctctacc atgtagtgga
     8221 agatatggct ctggtcgctc agattcctat gccccgtgtt ttcatcattg atgatccagc
     8281 cttaaatgcc tttgcgacag gttctaatcc tcaaaatgcg gctgttgctg cgacttcagg
     8341 tctactagct atcatgaatc gtgaagaact agaagctgtt atgggacatg aagtcagtca
     8401 tattcgtaat tatgatatcc gtatttcgac tattgcagtt gcccttgcta gtgctatcac
     8461 catgctttct agtatggcag gtcgtatgat gtggtggggt ggagcaggtc gcagacgaag
     8521 tgatgatgac cgagatggaa atggtcttga aatcattatg ctagtggttt ccctactagc
     8581 tattgtactg gcacctctcg ctgcaacctt ggttcagctc gctatttctc gtcagaggga
     8641 atttctggca gatgcatcta gtgtcgagct gactcgcaat ccccagggaa tgattaatgc
     8701 cctagataag ttggacaata gcaaacctat gagtcgccac gtcgatgatg ctagcagtgc
     8761 cctttatatc aatgatccta agaaaggtgg ggggttccaa aaactctttt atacccaccc
     8821 acctatctca gaacggattg aacgtttaaa acagatgtaa aagaatccag aggtcgtctc
     8881 tggatttttg ctatgttgca aatttataaa tcttctaaat taactagctt caaaccgtgt
     8941 tctgtcatgc gatagatgat cgagcagact tcttttaata aacgacggtc atgcgaaaca
     9001 gtgatgagac cgcctggata ggtagcaaag agttttctga tttggggttg agaagtggga
     9061 gaaaagtttc gtgtgggttc atccagcagg agaaagtttg gtttgcgcag gactaaatcc
     9121 aaaagcagga gttttccctg ttgtccgcca gataaggagc gaatttgatg ctgcatttct
     9181 ggataactga aattgagact agctaggtga gattggattt tctgtagttc ctctttttcc
     9241 ccagttttac tgagataggc tattggggat aaatccaatt gcagtttttt gtggtaatct
     9301 tgtggcataa aaccaagtga aatctctctt ttatcattca gaagtctctg taacttggct
     9361 aacagagttg atttcccaac accatttggc ccgataatac cgattttttc ttggccacgg
     9421 acagttagtt gtagtttttg aaccaaaact cggtcgtcaa tggacaaatt ttctttttcc
     9481 agttggacta agactttaga agctggtaat ggttggatgt ctgaaaagaa aagttggatt
     9541 tgttcctctt caagtggctt ttgagtcatg gactgagctg ccttttcgta gcgtttttct
     9601 tgtgagagga cagttttcat ctttttagcc aataggcgac cggcagtact atctttggta
     9661 gctcgaagcg cagtttctac attttgctta actctccgat gtttttccat ggttttatcg
     9721 taggctcttt ggttgttagc agcttgctga ctttgtttgg caaaattagc ctttctctgc
     9781 tcactatagc tatcatagtc taaatgctct actagcgttt ccgcttcttt acggtgtttg
     9841 accagtcgca agtgaacaat agtgtctgcc gtttcagaaa gaaagtcttc atcatgggaa
     9901 atgaaaataa cggtttgcct ggtcttttga atctggcctt ttagccaatc aactgtctca
     9961 aggtctaggt catttgaagg ttcatctaaa aatagaatct caaagggttt ggctaactca
    10021 tggataagct gaattttcaa agcttcgccc cctgatagat tgccaatctc ttggtcactt
    10081 gcgaaacgat tgctatcaaa atgcaattcc tccgccaaac gatagaggat actgtagtct
    10141 aaatcaatag aatctaaaaa gaagtagtcg tgtaaagttt tcttttttag gtcctcaggg
    10201 actttttgag gaatgtaggc cagtgactga tagtcagatt ggatgtttcc cttgatagtg
    10261 aaatcagaca aagcttcccc cattaaaatt ttaagtaagg ttgatttgcc atttccttct
    10321 tcaccaataa tagcaacctt ttccccgtct tggatggtca tggttaggtc agatacaaga
    10381 tctcgtaaat ctttgttttg tgtgatggtt agatgattga tttttatcat atgatttccc
    10441 tttctagaat gttcatagtg cataacaaaa agctctactt tacctagtag agcccaaagt
    10501 ctatgtcaaa aaaactctat taacatgcca gaaaaagagc ataaaagagc acacaaaaag
    10561 agacaaaaac aagatctact aaataaaggt tctttatttg atagacttag ttgttcatgt
    10621 ctcccttacc tccgagtatt agtatcttta tattatacct ttaaggaaat tttgtcaaca
    10681 gaaaactgga aattctatgc tctaaaattc aaaaacaggt ccatagagac ttagtacgtg
    10741 tttgacatga tcgtaatgga atttatcata gtttcgccaa gcagtgcgtg cttgatcgtt
    10801 tagttttagg ctacccagtc caatcagaag actggtaggt tggtaaaatt tctcaagatc
    10861 aattaagata ctgttgttca actgttccgt ttttttgagc tcttgcatag tagtgtttag
    10921 cagctcttgt agtcgaatat catctgccgt accctgttta cagttttggt agcttttatt
    10981 taacttggat aggagttgaa tgagtttctt gtcttccatg tgagcatcct ccttgatctg
    11041 atgtactctt tccctatagt atagcactaa aaaataaaac tatcatagta aatatgttaa
    11101 aattttgaat tttaattaca aagtttggtg tgctgatttg tagccttttc atggtataat
    11161 caagagagta aatctttatg gaggaagtat gaaattaaat attcaagaaa ttcgtaagca
    11221 gtctgaaggt ttgaactttg aacaaacgtt agatttagtt gatgacctgc gtgcacgtaa
    11281 tcaagaaatt ttagatgtaa aagatatcct tgcagttggg aaagtacaat atgaagaccg
    11341 tatgtatttc ttagattatc aactatctta taccattgtt cttgcttcga gtcgcagtat
    11401 ggagccagtt gagttagttg aatcttatcc agtcacggaa gttttcatgg aaggcgcaac
    11461 taaccagcta gatcaagaag ttttagatga tgacttggtc ttgcccatcg aaaatgggga
    11521 gcttgacctt gctgagagtg tatcagacaa tatcctgcta aacattccta tcaaggtctt
    11581 gacggctgaa gaagaagctg gtcaaggatt tatctcagga aatgactggc aaatcatgac
    11641 agaggaagaa taccaagctc aaaaagcagt aaagaaagaa gaaaacagtc cttttgctgg
    11701 cttacaagga ctatttgacg gagatgaata atggtcttgt caaaaaaacg agcacgaaag
    11761 gtgctagaag aaatcattgc cctcttccca gatgccaagc ctagtcttga ttttaccaat
    11821 cattttgaac tcctggttgc ggtcatgtta tcagcccaga cgacagatgc agcggtaaat
    11881 aaggccacac caggtctctt tgttgccttt ccaacacccc aagctatgtc tgtagcgaca
    11941 gagagtgaga ttgcttcaca tatttctcgc ttgggattgt atcggaataa agctaaattc
    12001 cttaaaaaat gtgcccaaca gttactagac gattttgatg gtcaagtccc tcagacacgt
    12061 gaagaattgg agagtttggc aggtgttggt cgcaagacag ccaatgttgt catgagtgta
    12121 ggatttggaa ttccagcctt tgcagtggat actcatgtgg agcgtatttg caaacaccac
    12181 gatattgtca aaaaatcagc gacgccactt gaggtggaaa agcgggtcat ggatatcttg
    12241 ccgcctgagc agtggttagc tgcccatcag gccatgattt attttggaag agccatttgc
    12301 catccaaaaa atccagagtg tgaccagtac ccacaattat atgattttag caatttgtaa
    12361 gatgctacat tgaaactttt tgcttgattt taagcatgct ttgtgctata gtaaatgata
    12421 actaaatatt cctttaaacc tgtcccgtga ggcaggcaag gagcgcgata aagtagaagg
    12481 gtgaagtcta tactgtgtgc agtagggctc gcttggctat aaatttcaag tctccttgtt
    12541 taaggagact tttctttttg gaggtttgtc atgaaaacaa aagaagttgt agacgaattg
    12601 accgtcaaac gagcgattac gcgtattact tatgagatta tcgaacgcaa caaagatttg
    12661 aataagatcg tcttggctgg tattaaaact cgtggtgtct ttattgccca ccgaatccaa
    12721 gaacgtttga agcagttaga aaatctttca gttcctgttg tggaattgga tactaaacct
    12781 ttccgtgatg atgttaaaag tggagaagat acttctttgg tttctgtcga tgtgacagac
    12841 cgcgaagtta tcttggtgga tgatgtgctc tatacaggtc gtaccatccg tgctgctatt
    12901 gataatattg tcggtcatgg tcgtcctgcg cgtgtgagtt tagcagttct agtcgatcgt
    12961 ggacatagag aattgccaat ccgtccagat tacgttggaa aaaatatccc aaccagtcgt
    13021 tctgaagaaa tcatcgtaga gatgacagaa cttgatgacc aagacagagt tctgattact
    13081 gaagaagctt agaaagttaa aggagtagcc atgtcagaaa atcaacaagc attgaaccat
    13141 gtggtgtcca tggaagacct cactgtcgat caagtaatga aattgatcaa gcgaggaatt
    13201 gagtttaaaa atggagccca gcttccctat gaagaccatc cgattgtttc caatctcttc
    13261 tttgaggatt ctacacggac acataagtcc tttgaagtcg cagagattaa acttggattg
    13321 gaacgacttg actttgatgt gaagactagc tcggttaata agggtgagac actttatgac
    13381 accattttga ctctgtctgc tttaggagtg gatgtctgtg tgattcgcca tccagaggtc
    13441 gactactata gagaattgat tgctagtcca acgattacga cttccatcat caatggtgga
    13501 gatggttcgg gccaacaccc tagccagagc ttgcttgatt tgatgaccat ttatgaggaa
    13561 tttggccact ttgagggtct taaagttgct attgcaggtg acttggacca ctcacgcgtt
    13621 gccaaatcca atatgcagat tttgaaacgc ttgggagctg aactcttttt cgctggacct
    13681 gaggaatgga gaagtcaaga gtttgcagac tatggacagt ttgtaaccat tgatgaaatc
    13741 attgatcagg ttgatgtcat gatgtttctc cgtgtgcaac acgaacgcca tgatagtgga
    13801 gctgtatttt caaaagaaga ctaccatgcc caacatggct tgactcaaga acgttacgat
    13861 cgtttgaaag aaacagcaat cctcatgcac ccagctccaa tcaatcgtga tgtagaaata
    13921 gcagaccact tggttgaagc accaaaatca cggattgtcc aacaaatgac caatggtgtc
    13981 tttgttcgaa tggcaatctt agaatccgta ctagcgagta gaaacgccaa ctaaaacaca
    14041 agacgttaaa agacgccagt gagcgtccac gagaggtgaa aatatgacaa aaagaattct
    14101 agtattagaa gatggcacag tttttgaagg caaggccttc ggagcagata ttgatgtaac
    14161 aggcgaaatc gtctttaata cagggatgac cggctaccaa gaatccatta cagaccagtc
    14221 ttataatgga caaatcttga cctttactta tcctttggta ggaaattatg gtattaatcg
    14281 tgatgattat gaatccatta ttccaacttg taagggagtc gttgtttttg aagaagcgcg
    14341 tagagctagc aactggcgca accaaatgac cttggatgaa tttttgaaag ccaagaaaat
    14401 tccagggatt tcaggaattg atacgcgtgc tcttaccaag attatccgta agcatggtac
    14461 tatgcgtgca accttgaccc atgttgggga cagtatggac catgtgacgg accagctcca
    14521 agcaacagtt ttaccgacag acaatatcaa acaggtttct actaaaacgt cttatccagc
    14581 tccaggagtt ggtttgagcg tggtgctagt ggactttggt ctcaagcact caatcctacg
    14641 tgaactttct aaacgcaact gtaacgtgac agttgttcct tattcgacaa cggctgaaga
    14701 aattctccat ctcaatcctg acggagttat gttgtcaaat ggtccaggta acccagaaga
    14761 cgttccacaa gcactcgaca tgattcgcgg tgtacaagga aaaattccaa tctttggtat
    14821 ttgtatggga caccaactct ttgcaatggc aaacggggct aagacctata agatgaagtt
    14881 tggccaccgt ggattcaacc atgcggtacg tgaaatcgca acaggacgag tagacttcac
    14941 cagccagaac catggttatg cagtcagccg cgaggatttg ccagagcact tgattattac
    15001 ccacgaagaa atcaatgaca agtcagtgga aggtgtgcgc cacagatacc aacctgcttt
    15061 ctctgttcaa taccacccag atgcagctcc tgggccacac gacgctagct acctatttga
    15121 cgagtttatc gagatgatgg aagtttttaa acaatcaaac taagaacgag taaaagctcg
    15181 tcggagaatt tatgtaactg aacacggacg gaaagctcag aatgtagaga aaccaacttg
    15241 gattgtcaat ccttccttga tttcctaaaa ttcaatcgct ttctattcgt cctttgtatc
    15301 ttatttaatg tcgccctgag aggcgacgaa tagaaaggag aagggtgctc cgtatttgct
    15361 gaactgaata cgggctacgg acggtgctaa aaagatagtt attcctagaa ctgacagttc
    15421 ttcgtcataa ctcctatttt agctttgtcc gcttgacacc cttaatatct tatatatgcc
    15481 taaacgtact gatattcaaa aaattatggt gattggttct ggtccgatta ttattggtca
    15541 ggctgctgag tttgactacg ctgggactca ggcttgcttg tcgttgaaag aggaaggtta
    15601 tgaggttgtt ttggttaact caaatcctgc aaccatcatg acggacaagg aaattgctga
    15661 caaggtttac attgaaccga ttacacttga gtttgtgaca cgtattcttc gtaaggaagg
    15721 tccagatgcc ttgctaccaa cactcggtgg tcagacaggt ctcaacatgg ccatggaatt
    15781 atctaaaaat ggtatcctag acgagcttgg cgttgaactt ctgggtacca aattatctgc
    15841 cattgaccaa gcggaggacc gtgacctctt taaacaattg atggaagagc ttgaacaacc
    15901 cattccagaa tctgaaattg ttaacacagt agaagaagca gttgcctttg cagcgacaat
    15961 tggctaccca gtcatcgttc gtccagcctt tacccttggt ggtactggtg gtggtatgtg
    16021 tgccaacgag aaagaattgc gtgaaatcac tgaaaatggt ttgaaattgt cacctgttac
    16081 ccaatgtttg attgagcgtt cgattgccgg tttcaaggaa attgaatacg aagtgatgcg
    16141 tgactcagct gacaatgcct tggttgtttg taacatggaa aactttgacc cagttgggat
    16201 tcacacaggg gattccattg tatttgcccc tgcgcaaacc atgtcagact atgaaaacca
    16261 aatgcttcgt gatgcgagct tgagcattat tcgtgccctc aagattgaag gtggatgtaa
    16321 tgttcagcta gctcttgatc ctaacagctt caagtattat gttatcgaag taaaccctcg
    16381 tgtatcacgt tcgtcagccc ttgcttctaa agcgacagga tatccgattg ctaagttggc
    16441 tgccaagatt gcagtaggtt tgaccttgga tgaggttata aacccagtta caggttcaac
    16501 ctatgccatg tttgaaccag cccttgacta cgtagttgct aagattccac gtttcccatt
    16561 tgacaagttt gaaaagggtg aacgccgtct cggtacacaa atgaaggcga ctggagaagt
    16621 catggcaatc ggtcgtaaca tcgaggaatc tcttctcaag gcctgccgct cccttgaaat
    16681 tggggtgcac cacaatgaaa tacctgaact tgcagcagtt tctgatgatg ccttgattga
    16741 aaaggttgtc aaagcccaag atgaccgtct cttctacgta tcagaagcca ttcgtcgtgg
    16801 ctacacacct gaagaaattg cagagcttac aaaaattgat atcttctatc ttgataaact
    16861 cttgcatatc tttgaaattg agcaagaatt gggtgctcat ccacaagatt tagaagtttt
    16921 gaaaacagcc aaacttaatg gtttttcaga ccgtaagatt gctgaactct ggggaacgac
    16981 tgatgataaa gttcgccaac ttcgcttgga aaacaagatt gttccagttt ataagatggt
    17041 agacacttgt gcggcagagt tcgactccga aacgccatat ttctattcaa cctatggttg
    17101 ggaaaatgaa tctatcagat ctgataaaga atctgtactt gtcctaggtt caggtccaat
    17161 ccgtatcggt caaggggttg agtttgacta cgcaaccgtt cactctgtta aggctatcca
    17221 ggcagctggt tatgaagcta tcatcatgaa ctcaaaccca gagaccgttt caacagactt
    17281 ctctgtatca gataagcttt actttgagcc attgacattc gaagatgtta tgaacgtcat
    17341 tgacttggaa caaccaaagg gagttatcgt tcagttcggt ggtcaaacag ccatcaacct
    17401 tgcggagcca ttggcaaaag caggtgtgac catccttggt acacaggttg ctgacctaga
    17461 tcgtgccgaa gaccgtgacc tcttcgagca agctctcaaa gaattggata ttccacagcc
    17521 accaggacaa acggctacca atgaagaaga agcagctctt gcagctcgca agattggctt
    17581 cccagttctt gtccgcccat cttatgtact tggtggacgt gccatggaaa tcgttgaaaa
    17641 cgaagaagac cttcgttctt acatgcgaac tgctgttaag gctagtccag accacccagt
    17701 tcttgtcgac tcttatatcg ttgggcaaga gtgcgaagtt gatgccattt cagatggtaa
    17761 aaatgtactc attcctggta tcatggagca tatcgaacgt gctggtgtcc actcaggtga
    17821 ctcaatggct gtttacccac cacaaacctt gtcgcaaaag gttcaggaga ccatcgcaga
    17881 ctacaccaaa cgcttagcaa tcggtcttca ctgccttgga atgatgaaca tccagtttgt
    17941 tatcaaggat gaaaaagtct acgttattga ggtcaatcca cgtgccagcc gtactgttcc
    18001 attcctatct aaggtaacca atattcctat ggctcaagta gcgaccaaac tcattcttgg
    18061 tcaaagttta tcagaacttg gctaccaaaa tggactttac cctgaaagca cccgtgttca
    18121 tatcaaggca cctgtcttct cctttaccaa actagctaag gtagacagct tgctcggtcc
    18181 tgaaatgaag tcaacaggtg aagttatggg ttctgatgct actttggaaa aagctctcta
    18241 taaagccttt gaagcttctt atctacactt gccaactttt ggtaatgtcg tctttaccat
    18301 cgctgatgat gccaaagaag aagccttgaa cttggctcgt cgtttccaaa acattggtta
    18361 tggaatcctt gcgacagaag ggacagcagc cttctttgct agtcatggct tgcaagccca
    18421 acctgttggt aagattggtg atgacgataa ggatatccca agttttgtac gcaaaggaag
    18481 aattcaagct atcattaaca cagtaggaac aaaacgaact gctgacgaag atggtgagca
    18541 aattcgtcgt tcagccattg aacacggggt gcccctcttc acagcgctag atacagctaa
    18601 tgccatgctt aaggtacttg aaagtcgtag ctttgttaca gaagcgattt aaatagaaaa
    18661 ataag
//
LOCUS       DAVLHC010000038        18648 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.038, whole genome shotgun sequence.
ACCESSION   DAVLHC010000038 DAVLHC010000000
VERSION     DAVLHC010000038.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 18648)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18648)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18648
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.038"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..430
                     /locus_tag="VXE25_001554"
     CDS             <1..430
                     /locus_tag="VXE25_001554"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEV0771994.1"
                     /translation="ADNQEQLFDQVATLLEEREIVTPTYREALITREKSFPTGLDMEF
                     LGKDLPNVAIPHTDIVHNLAEKVVVVRLEKPVTFHNMIAPDKEVEVSLLFFIINNSSS
                     SQTNILAQLMDFFTGNGHLEDLSKISEPEKLYAYIAEATA"
     gene            468..773
                     /locus_tag="VXE25_001555"
     CDS             468..773
                     /locus_tag="VXE25_001555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000590575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEV0771995.1"
                     /translation="MIKILAACGAGVNSSHQIKSALEEELSNRGYDVHCDAVMVKDVN
                     EDLMKGYDIFTPIAATDLGFEPGIPVIEAGPILFRIPAMSAPVFDNIEAAIKEHGLS"
     gene            821..2296
                     /locus_tag="VXE25_001556"
     CDS             821..2296
                     /locus_tag="VXE25_001556"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000338710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS galactitol transporter subunit IIC"
                     /protein_id="HEV0771996.1"
                     /translation="MDAIFDLIGKVFNPILEMGGPVIMLIILTVLALLFGVKFSKALE
                     GGIKLAIALTGIGAIIGMLNGAFSASLAKFVENTGIQLSITDVGWAPLATITWGSAWT
                     LYFLLIMLIVNVVMLAMKKTDTLDVDIFDIWHLSITGLLIKWYADNNGVSQGVSLLIA
                     TAAIVLVGVLKIINSDLMKPTFDDLLNAPSSSPMTSTHMNYMMNPVIMVLDKIFEKFF
                     PGLDKYDFDAAKLNKKIGFWGSKFFIGFILGIVIGIMGTPHPIAGVADADKWRLVIKG
                     WLSLGLTAGVSLELFSLIGSWFIAAVEPLSQGITNVATKRLQGRKFNIGLDWPFIAGR
                     AEIWACANVLAPIMLIEAVLLSKVGNGILPLAGIIAMGVTPALLVVTRGKLLRMIIFG
                     TLLLPLFLLSGTLIAPFATELAKGVGAFPEGVSQTQLITHSTLEGPIEKLLGWTIGNT
                     TTGDIKAILGAVAFLVFYIGIFAWYRKQMIKRNEEYAAKAK"
     gene            2319..2396
                     /locus_tag="VXE25_001557"
                     /pseudo
     CDS             2319..2396
                     /locus_tag="VXE25_001557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            2646..9347
                     /locus_tag="VXE25_001558"
     CDS             2646..9347
                     /locus_tag="VXE25_001558"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Ig-like domain-containing protein"
                     /protein_id="HEV0771997.1"
                     /translation="MGKGHWNRKRVYSIRKFAVGACSVMIGTCAVLLGGNIAGESVVY
                     ADETLITHTAEKPKEEKMIVEEKADKALETKNVVERTEQSEPSSTEAIASEKKEDEAV
                     TPKEEKVSAKPEEKAPRIESQASSQEKPLKEDTKAVTNEEVNQMIEDRKVDFNQNWYF
                     KLNANSKEAIKPDADVSTWKKLDLPYDWSIFNDFDHESPAQNEGGQLNGGEAWYRKTF
                     KLDEKDLKKNVRLTFDGVYMDSQVYVNGQLVGHYPNGYNQFSYDITKYLHKDGRENVI
                     AVHAVNKQPSSRWYSGSGIYRDVTLQVTDKVHVEKNGTTILTPKLEEQQHGKVETHVT
                     SKIVNTDDKDHELVAEYQIVERGGHAVTGLVRTASRTLKAHESTSLDAILEVERPKLW
                     TVLNDKPALYELITRVYRDGQLVDAKKDLFGYRYYHWTPNEGFSLNGERIKFHGVSLH
                     HDHGALGAEENYKAEYRRLKQMKEMGVNSIRTTHNPASEQTLQIAAELGLLVQEEAFD
                     TWYGGKKPYDYGRFFEKDATHPEARKGEKWSDFDLRTMVERGKNNPAIFMWSIGNEIG
                     EANGDAHSLATVKRLVKVIKDVDKTRYVTMGADKFRFGNGSGGHEKIADELDAVGFNY
                     SEDNYKTLRAKHPKWLIYGSETSSATRTRGSYYRPERELKHSNGPERNYEQSDYGNDR
                     VGWGKTATASWTFDRDNAGYAGQFIWTGTDYIGEPTPWHNQNQTPVKSSYFGIVDTAG
                     IPKHDFYLYQSQWVSVKKKPMVHLLPHWNWENKELASKVADSEGKIPVRAYSNASSVE
                     LFLNGKSLGLKTFNKKQTSDGQTYQEGANANELYLEWKVAYQPGTLEAIARDESGKEI
                     ARDKITTAGKPAAVRLIKEDHAIAADGKDLTYIYYEIVDSQGNVVPTANNLVRFQLHG
                     QGQLVGVDNGEQASRERYKAQADGSWIRKAFNGKGVAIVKSTEQAGKFTLTAHSDLLK
                     SNQVTVFTGKKEGQEKTVLGTEVARVRTLIGKEPKMPKTVGFVYSDGSREKLPVTWSQ
                     VDVSQAGVVTVKGTANGREVEAHVEVLAIAKELPTVKRIAPNTDLNSVDKSVSYVLTD
                     GSVQEYEVDSWEITEVDKAKLSVAGSRIQMTGQLAGETIHATLVVEEGNAAAPVVPTV
                     TVGGEAVTGLTSRQPMQYRTLSYGAQLPEVTASAENADVTVLQASAANGMRASIFIQP
                     KDGGPLQTYAIQFLEEAPKIAHLSLQVEKADSLKEDQTVKLSVRAHYQDGTQAVLPAD
                     KVTFSTSGEGEVAIRKGMLELHKPGAVTLKAEYEGAKGQVELTIQANTEKKIAQSIRP
                     VNVVTDLHQKPTLPTTVTVEYDKGFPKAHKVTWQAIPKEKLDSYQTFEVLGKVEGIDL
                     EARAKVSVEGIVSVEEVSVTTPIAEAPQLPESVRTYDSNGHVSSAKVAWDAIRPEQYA
                     KEGVFTVNGRLEGTQLTTKLHVRVSAQTEQGANISDQWTGSELPLAFASDSNPSDPVS
                     NVNDKLISYNNQPANRWTNWNRTNPEASVGVLFGDSGILSKRSVDNLSVGFHEDHGVG
                     APKSYVIEYYVGKTVPTAPKNPSFVGNEDHVFNDSANWKPVTNLKAPAQLKAGEMNHF
                     SFDKVETYAVRIRMVRADNKLGTSITEVQIFAKQVAAAKQGQTRIQVDGKDLANFNPD
                     LTDYYLESVDGKVTAVTASVSNNGLATVVPSVREGEPVRVIAKAENGDILGEYRLHFT
                     KDKNLLSHKPVAAVKQARLLQVGQALELPTKVPVYFTGKDGYETKNLTVEWEEVPAEN
                     LIKAGQFTVRGHVLGSDLVAEVTVRVTDKLGEALSDNPNYDENSNQAFASATNDIDKN
                     SHDRVDYLNDGDHSENRRWTNWSPTPSSNPEVSAGVIFRENGKIVERTVAQAKLHFFA
                     DSGTDAPTKLVLERYVGPEFEVPTYYSNYQAYDADHPFNNPENWEAVPYRADKDIAAG
                     DEINVTFKAVKAKAMRWRMERKADKSGVAMIEMTFLAPSELPQESTQSKILVDGKELA
                     DFAENRQDYQITYKGQRPKVSVEENNQVASTVVDSGEDSLPVLVRLVSESGKQVKEYR
                     IQLTKEKPVSEKTVAAVQEDLPKLEFVEKDLAYKTVEKKDSTLYLGETRVEQEGKTGK
                     ERIFTAINPDGSKEEKLREVVEAPTDRIVLVGTKPVAQEAKKPQVSEKADTKPIDSSE
                     ASQTNKAQLPNTGSAASQAAVAAGLALLGLSAGLVVTKGKKED"
     gene            complement(9595..10451)
                     /locus_tag="VXE25_001559"
                     /pseudo
     CDS             complement(9595..10451)
                     /locus_tag="VXE25_001559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006270419.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(10662..11021)
                     /locus_tag="VXE25_001560"
     CDS             complement(10662..11021)
                     /locus_tag="VXE25_001560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004249826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3397 domain-containing protein"
                     /protein_id="HEV0771998.1"
                     /translation="MGMILMKLASILLLILTLVVCIILTKLFRLKKLGRNFADLAFPV
                     LVFEYYLITAKTFTHNFLPRLGLALSFLAIILVFFFLLKKRSFYYPKFIKFFWRTGFL
                     LTLIMYIEMIVELFLMK"
     gene            11113..12069
                     /locus_tag="VXE25_001561"
                     /pseudo
     CDS             11113..12069
                     /locus_tag="VXE25_001561"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002881980.1"
                     /note="This family includes YhcC from E. coli K-12, an
                     uncharacterized radical SAM protein.; internal stop;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01212 family radical SAM protein"
     gene            12053..12610
                     /locus_tag="VXE25_001562"
     CDS             12053..12610
                     /locus_tag="VXE25_001562"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000828405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HEV0771999.1"
                     /translation="MKRPLEMAHDFLAEVVTKEDVVVDATMGNGHDTLFLAKLAKQVY
                     AFDIQKQALEKTQERLHQAGLTNAQLILQGHETLDQFVTKAKAGIFNLGYLPSADKSV
                     ITRPQTTIEALEKLCGLLVKGGRIAIMIYYGHEGGDLERDAVLDFVIQLNQQEYTAAI
                     YRTLNQVNNPPFLVMIEKLERYRHG"
     gene            12603..12857
                     /locus_tag="VXE25_001563"
     CDS             12603..12857
                     /locus_tag="VXE25_001563"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000361102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772000.1"
                     /translation="MDKQYLHEKLDAMRQNFVESTYHERAVGVLDQAHMSKKMLKIKK
                     KLVALEMERCQRKIEHKDCSKIDQKIKEQKEIFESCCKKD"
     gene            12869..14923
                     /locus_tag="VXE25_001564"
     CDS             12869..14923
                     /locus_tag="VXE25_001564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000421632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation:proton antiporter"
                     /protein_id="HEV0772001.1"
                     /translation="MELLIYLILFLLVLIVSSTTNKLLPFLPLPLVQILLGIVIGLFL
                     PNTDFHLNTELFLALVIGPLLFREAEEADVTAILKHWRIIVYLIFPVIFISTLSLGGL
                     AHLLWFSLPLAACLAVGAALGPTDLVAFASLSERFSFPKRVSNILKGEGLLNDASGLV
                     AFQVALTAWTTGAFSLGQASSSLIFSILGGFLIGFLTAMTNRFLHTFLLSVRATDIAS
                     ELLLELSLPLVTFFLAEEVHVSGIIAVVVAGILKASRFKKITLLEAQVDTVTETVWHT
                     VTFMLNGSVFVILGMELEMIAEPILTNPIYNPLLLLLSLIALTFVLFVIRFIMIYGYY
                     AYRTRRLKKKLNKYMKDMFLLTFSGVKGTVSIATILLIPSNLEQEYPLLLFLVAGVTL
                     VSFLTGLLVLPHLSDEEEESKDYLMHIAILNEVTLELEKELEDTRNKLSLYAAIDNYH
                     GRIENLILSQENQDDQEDWAALKFLILSIESDGLEQAYEEGNISNRAYRVYQRYLKNI
                     EQGINRKLASRLTYYFLVSLRILRFLLHEVFTLGKTFRSWKDKEQSRLRALDYDQIAE
                     LYLANTEMIIESLENLKGVYRRSLISFMQESRLRETAIISSGAFVERVINRVKPNNID
                     EMLRGYYLERKLIFEYEEKRLITTKYAKKLRQNVNNLENYSLKEAANTLPYDMVELVR
                     RN"
     gene            15102..15962
                     /locus_tag="VXE25_001565"
     CDS             15102..15962
                     /locus_tag="VXE25_001565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YihY/virulence factor BrkB family protein"
                     /protein_id="HEV0772002.1"
                     /translation="MKKWWKELIDKPLLKAFLHYYQASDSELTSVAVAYYWLISIFPL
                     LLVVVNILPYFQIPVGEFLCFMKDVLPPSLYEGVEKIAREVLTQPSTGLLSFSVLSAL
                     WSFSKSMNFLQKAFNKAYGVEKSRGLISHQMLSLLVSFGLQLLFAFALFLILFGQMIL
                     ALLAHYWTKDGIIYQALQGLAGPLIYALLFAILVMLYYFLPNISNRKISYTLPGSAFV
                     LLVILGLLTLFSSYLNYYVHHLVDVRILGSVLLVVMMFWFILIAKIVILGAVINASMQ
                     SLRDPVFKKD"
     gene            16173..16883
                     /gene="ccdA2"
                     /locus_tag="VXE25_001566"
     CDS             16173..16883
                     /gene="ccdA2"
                     /locus_tag="VXE25_001566"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000509848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol-disulfide oxidoreductase-associated
                     membrane protein CcdA2"
                     /protein_id="HEV0772003.1"
                     /translation="MGHIFFFLSVFLAGILSFFSPCILPLLPVYTGVLLDDKDGAQAS
                     SGKFSISVTSLLRTLAFIAGISFIFILLGYGAGFLGDLLYASWFQYLTGAIIILLGLH
                     QMEILHFKGLYKEKRLQLQGQGQNGKGYSQAFLLGLTFSFAWTPCVGPVLGSVLALAA
                     SGGSGAWQGAGLMLVYTLGLALPFLLLALTSSYVLKHFRKLHPYLGILKKVGGFLIIV
                     MGLLVLFGNASILSQLFE"
     gene            16903..17469
                     /locus_tag="VXE25_001567"
     CDS             16903..17469
                     /locus_tag="VXE25_001567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000759281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redoxin family protein"
                     /protein_id="HEV0772004.1"
                     /translation="MKKWQTCVLGAGSLLCLTACSGKSVTSEHQTKDEMKTEQTASKT
                     SAAKGKEVADFELMGVDGKTYRLSDYKGKKVYLKFWASWCSICLASLPDTDEIAKEAG
                     DDYVVLTVVSPGHKGEQSEADFKNWYKGLDYKNLPVLVDPSGKLLETYGVRSYPTQAF
                     IDKEGKLVKTHPGFMEKDAILQTLKELA"
     gene            17480..18592
                     /gene="msrB"
                     /locus_tag="VXE25_001568"
     CDS             17480..18592
                     /gene="msrB"
                     /locus_tag="VXE25_001568"
                     /EC_number="1.8.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730371.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="HEV0772005.1"
                     /translation="MNDKLKIFLLLGVFFLAITGFYVLLIRNAGQTDASQIEKAAVSQ
                     GGKAVKKTEISKDADLHEIYLAGGCFWGVEEYFSRVPGVTDAVSGYANGRGETTKYEL
                     INQTGHAETVHVTYDAKQISLKEILLHYFRIINPTSKNKQGNDVGTQYRTGVYYTDDK
                     DLEVINQVFDEVAKKYDQPLAVEKENLKNFVVAEDYHQDYLKKNPNGYCHINVNQAAY
                     PVIDASKYPKPSDEELKKTLSPEEYAVTQENQTERAFSNRYWDKFESGIYVDIATGEP
                     LFSSKDKFESGCGWPSFTQPISPDVVTYKEDKSYNMTRMEVRSRVGDSHLGHVFTDGP
                     QDKGGLRYCINSLSIRFIPKDQMEEKGYAYLLDYVD"
BASE COUNT         5649 a         3534 c         4076 g         5389 t
ORIGIN      
        1 agcggataat caagaacaac tctttgatca ggttgcaact ttattggaag aacgagaaat
       61 tgtcactcca acttatcgtg aagccttgat cacgcgtgaa aagtcatttc caactggttt
      121 agatatggaa tttctaggaa aggacttgcc aaatgtagcg attcctcata cagatattgt
      181 tcataatcta gctgagaaag tggtggttgt tcgattagaa aaaccagtaa cttttcacaa
      241 tatgatagct cctgataagg aagtagaagt atccttgctc ttctttatca tcaataactc
      301 aagttcaagt caaacaaata ttctggctca gttgatggac tttttcacag gaaatggaca
      361 tcttgaagac ctatcaaaaa tttccgaacc agaaaaactt tatgcttaca ttgctgaagc
      421 aaccgcttaa tcttgtctat taaaaaataa aatcggagga aatctaaatg attaaaattc
      481 ttgctgcctg cggtgcaggt gttaactcaa gtcaccaaat taaaagtgct ctagaagaag
      541 aactttcaaa ccgtggttat gatgttcact gtgatgcagt catggtgaaa gatgtaaacg
      601 aagaccttat gaaaggttac gatatcttta caccaatcgc tgcaacagac cttggttttg
      661 aaccaggtat cccagttatc gaagctggac caatcttatt ccgtatccca gcaatgagcg
      721 ctccagtatt tgacaatatt gaagcagcta ttaaagaaca cggattaagc taattctaat
      781 ttgttaacat tcatataaca taaaaaaggg aggaactgtt atggatgcaa tctttgacct
      841 aatcggaaag gttttcaatc ccatcttaga aatgggtgga cctgtcatca tgttaatcat
      901 tttgacagta ttggctttac tttttggagt gaaattctcc aaagcgcttg aaggtggtat
      961 caaacttgcc atcgctctta caggtatcgg tgctatcatc ggtatgctaa atggtgcttt
     1021 ctcagcatca cttgcaaaat tcgttgaaaa cactggtata caattgagta ttaccgacgt
     1081 tggttgggca ccacttgcaa caatcacttg gggttctgct tggacacttt acttcttgct
     1141 catcatgttg attgtcaacg tagtgatgct tgctatgaag aaaaccgata cacttgatgt
     1201 cgatatcttt gatatctggc acttgtctat cacaggtctt ttgattaaat ggtatgctga
     1261 taacaatggt gtgagtcaag gggtttcact cttgattgct acagcagcta tcgttcttgt
     1321 cggtgtgttg aaaattatca actctgactt gatgaaacct acatttgatg accttcttaa
     1381 cgccccaagt tcatcaccaa tgacatcaac tcacatgaac tacatgatga acccagttat
     1441 catggttttg gataagattt ttgaaaaatt cttcccaggc cttgataaat atgactttga
     1501 tgctgctaaa ttgaacaaga aaatcggttt ctggggatct aaattcttca tcggtttcat
     1561 ccttggtatc gttatcggta ttatgggaac tccacatcca attgcaggtg ttgcagatgc
     1621 agataaatgg cgtcttgtta tcaaaggatg gttgtctctt ggtttgactg ccggtgtatc
     1681 tttggaactc ttctcactta tcggttcatg gttcatcgca gccgtagaac cactatcaca
     1741 aggtattaca aacgttgcta ctaaacgtct tcaaggacgt aaattcaata tcggtcttga
     1801 ctggccattc atcgctggtc gtgctgaaat ctgggcttgt gccaacgtac ttgcaccaat
     1861 catgttgatt gaagcagtgc ttctttcaaa agttggaaat ggtatcttgc cacttgcagg
     1921 tatcatcgct atgggtgtta ctccagctct cttggttgta actcgtggta aattgctccg
     1981 tatgattatc ttcggaacac tcttgttgcc actcttcctt ctttcaggta cacttattgc
     2041 accatttgca acagaacttg ctaaaggtgt aggtgccttc ccagaaggtg tgagccaaac
     2101 tcaattgatt actcactcta ctcttgaagg accaatcgaa aaacttcttg gttggacaat
     2161 tggtaacact acaactggtg atatcaaagc aatccttggt gcagtagcct tccttgtatt
     2221 ctatatcggt atctttgctt ggtacagaaa acaaatgatc aaacgtaacg aagagtacgc
     2281 agcaaaagca aaataatgcg ctcctataaa atataaactc aatgaaaatc aaagagcaaa
     2341 ctaggaagct agccgcaggt tgctcaaaac acagttttga ggttgtagat aagactgacg
     2401 aagtcagctc aaaacatggt tttgaggttg tagatgaaac tgacgaagtc agctcaaaac
     2461 atggttttga ggttgtagat gaaactgacg aagtcagtaa tcatatctac ggcaaggcga
     2521 cactgacgaa gtttgaattg gattttcgca gagtgtaaat tgttgaaact aggttgtcat
     2581 accatgtata ccacttgggc tttggtagta gctaactgca ctaaatataa tataaggagg
     2641 gttttatggg gaaaggccat tggaatcgga aaagagttta tagcattcgt aagtttgctg
     2701 tgggagcttg ctcagtaatg attgggactt gtgcagttct attaggagga aatatagctg
     2761 gagaatctgt agtttatgcg gatgaaacac ttattactca tactgctgag aaacctaaag
     2821 aggaaaaaat gatagtagaa gaaaaggctg ataaagcttt ggaaactaaa aatgtagttg
     2881 aaaggacaga acaaagtgaa cctagttcaa ctgaggctat tgcatctgag aagaaagaag
     2941 atgaagccgt aactccaaaa gaggaaaaag tgtctgctaa accggaagaa aaagctccaa
     3001 ggatagaatc acaagcttca agtcaagaaa aaccgctcaa ggaagatact aaagctgtaa
     3061 caaatgaaga agtgaatcaa atgattgaag acaggaaagt ggattttaat caaaattggt
     3121 actttaaact caatgcaaat tctaaggaag ccattaaacc tgatgcagac gtatctacgt
     3181 ggaaaaaatt agatttaccg tatgactgga gtatctttaa cgatttcgat catgaatctc
     3241 ctgcacaaaa tgaaggtgga cagctcaacg gtggggaagc ttggtatcgc aagactttca
     3301 aactagatga aaaagacctc aagaaaaatg ttcgccttac ttttgatggc gtctacatgg
     3361 attctcaagt ttatgtcaat ggtcagttag tggggcatta tccaaatggt tataaccagt
     3421 tctcatacga tatcaccaaa taccttcaca aagatggtcg tgagaatgtg attgctgtcc
     3481 atgcagtcaa caaacagcca agtagccgtt ggtattcagg aagtggtatc tatcgtgatg
     3541 tgactttaca agtgacagat aaggtgcatg ttgagaaaaa tgggacaact attttaacac
     3601 caaaacttga agaacaacaa catggcaagg ttgaaactca tgtgaccagc aaaatcgtca
     3661 atacggacga caaagaccat gaacttgtag ccgaatatca aatcgttgaa cgaggtggtc
     3721 atgctgtaac aggcttagtt cgtacagcga gtcgtacctt aaaagcacat gaatcaacaa
     3781 gcctagatgc gattttagaa gttgaaagac caaaactctg gaccgtttta aatgacaaac
     3841 ctgccttgta cgaattgatt acgcgtgttt accgtgacgg tcaattggtt gatgctaaga
     3901 aggatttgtt tggttaccgt tactatcact ggactccaaa tgaaggtttc tctttgaatg
     3961 gtgaacgtat taaattccat ggagtatcct tgcaccacga ccatggggcg cttggagcag
     4021 aagaaaacta taaagcagaa tatcgccgtc tcaaacaaat gaaggagatg ggagttaact
     4081 ccatccgtac aacccacaac cctgctagtg agcaaacctt gcaaatcgca gcagaactag
     4141 gtttactcgt tcaggaagag gcttttgata cttggtatgg tggcaagaaa ccttatgact
     4201 atggacgttt ttttgaaaaa gatgccactc acccagaagc tcgaaaaggt gaaaaatggt
     4261 ctgattttga cctacgtacc atggtcgaaa gaggcaaaaa caaccctgct atcttcatgt
     4321 ggtcaattgg taatgaaata ggtgaagcta atggtgatgc ccactcttta gcaactgtta
     4381 aacgtttggt caaggttatc aaggatgttg ataagactcg ctatgttacc atgggagcag
     4441 ataaattccg tttcggtaat ggtagcggag ggcatgagaa aattgctgat gaactcgatg
     4501 ctgttggatt taactattct gaagataatt acaaaaccct tagagctaag catcccaaat
     4561 ggttgattta tggatcagaa acatcttcag ctacccgtac acgtggaagt tactatcgcc
     4621 ctgaacgtga attgaaacat agcaatggac ctgagcgtaa ttatgaacag tcagattatg
     4681 gaaatgatcg tgttggttgg gggaaaacag caaccgcttc atggactttt gaccgtgaca
     4741 acgctggcta tgctggacag tttatctgga caggtacgga ctatattggt gaacctacac
     4801 catggcacaa ccaaaatcaa actcctgtta agagctctta ctttggtatc gtagatacag
     4861 ccggcattcc aaaacatgac ttctatctct accaaagtca atgggtttct gttaagaaga
     4921 aaccgatggt acaccttctt cctcactgga actgggaaaa caaagaatta gcatccaaag
     4981 tagctgactc agaaggtaag attccagttc gtgcttattc gaatgcttct agtgtagaat
     5041 tgttcttgaa tggaaaatct cttggtctta agactttcaa taaaaaacaa accagcgatg
     5101 ggcagactta ccaagaaggt gcaaatgcta atgaacttta tcttgaatgg aaagttgcct
     5161 atcaaccggg taccttggaa gcaattgctc gtgatgaatc tggcaaggaa attgctcgag
     5221 ataagattac gactgctggt aagccagcgg cagttcgtct tattaaggaa gaccatgcga
     5281 ttgcagcaga tggaaaagac ttgacttaca tctactatga aattgttgac agccagggga
     5341 atgtggttcc aactgctaat aatctggttc gcttccaatt gcatggccaa ggtcaactgg
     5401 tcggtgtaga taacggagaa caagccagcc gtgaacgcta taaggcgcaa gcagatggtt
     5461 cttggattcg taaagcattt aatggtaaag gtgttgccat tgtcaaatca actgaacaag
     5521 cagggaaatt caccctgact gcccactctg atctcttgaa atcgaaccaa gtcactgtct
     5581 ttactggtaa aaaagaagga caagagaaga ctgttttggg gacagaagta gcaagagttc
     5641 gtacattaat tggtaaagaa ccaaaaatgc cgaaaacagt aggttttgta tacagcgatg
     5701 gtagtcgtga aaaacttcca gtaacttggt ctcaagtcga tgttagtcaa gcaggagttg
     5761 tgactgttaa aggtacagca aatggacgtg aggtagaggc tcatgtcgag gttctagcaa
     5821 ttgcgaaaga attaccaaca gttaaacgta ttgctccaaa tactgacttg aattctgtag
     5881 acaaatctgt ttcttatgtt ttgactgatg gaagtgtaca agagtacgaa gtagatagct
     5941 gggagattac ggaagtagat aaagccaaac tttcagtagc tggatcacgt attcaaatga
     6001 ctggtcagtt agctggagaa actattcatg caacccttgt ggtagaagaa ggaaatgctg
     6061 cagcacctgt agtgccaact gttactgttg gaggtgaggc agtaacaggt cttactagtc
     6121 gacaaccaat gcaatatcgt actctatctt atggtgccca actgccagaa gtcacagcaa
     6181 gtgctgaaaa tgctgatgtg acagttcttc aagcaagcgc agcaaacggc atgcgtgcga
     6241 gcatctttat tcagcctaaa gatggtggtc ctcttcaaac ctatgcaatt caattccttg
     6301 aagaagcgcc aaaaattgct cacttgagtt tgcaagtgga aaaagctgac agtctcaaag
     6361 aagaccaaac tgtcaaattg tcggttcgag ctcactatca agatggaacg caagctgtat
     6421 taccagctga taaagtaacc ttctctacaa gtggtgaagg ggaagtcgca attcgtaaag
     6481 gaatgcttga gttgcataag ccaggagcag tcactctcaa agcggaatat gagggagcta
     6541 aaggccaagt tgaactcact atccaagcca atactgagaa gaagattgcg caatctatcc
     6601 gtcctgtaaa tgtagtcaca gatttgcatc aaaaacctac tcttccaaca acagtaacgg
     6661 ttgagtatga caaaggtttc cctaaagctc acaaagtcac ttggcaagct attccgaaag
     6721 aaaaactaga ctcctatcaa acatttgaag tactaggtaa agttgaagga attgaccttg
     6781 aagcgcgtgc aaaagtctct gtagaaggta tcgtttcagt tgaagaagtc agtgtgacaa
     6841 ctccaatcgc agaagcacca caattaccag aaagtgttcg gacatatgat tcaaatggtc
     6901 acgtttcatc agctaaggtt gcatgggatg cgattcgtcc agagcaatac gctaaggaag
     6961 gtgtctttac agttaatggt cgcttagaag gtactcaatt aacaactaaa cttcatgttc
     7021 gcgtatctgc tcaaactgag caaggtgcaa acatttctga ccaatggacc ggttcagaat
     7081 tgccacttgc ctttgcttca gactcaaatc caagcgaccc agtttcaaat gttaatgaca
     7141 agctcatttc ctacaataac caaccagcca atcgttggac aaactggaat cgtactaatc
     7201 cagaagcttc agtcggtgtc ctattcggag attcaggtat tttgagcaaa cgttcagttg
     7261 ataacttaag cgttggcttc catgaagacc atggagttgg tgcaccgaag tcttatgtga
     7321 ttgagtatta tgttggtaag actgtcccaa cagctcctaa aaaccctagt tttgttggta
     7381 atgaggacca tgtctttaat gattctgcca actggaaacc agttactaat ctaaaagccc
     7441 ctgctcaact caaggctgga gaaatgaacc actttagctt tgataaagtt gaaacctatg
     7501 ctgttcgtat tcgcatggtg agagcagaca acaaactagg aacgtctatc acagaggtac
     7561 aaatctttgc gaaacaagtt gcggcagcca agcaaggaca aacaagaatc caagttgacg
     7621 gtaaagactt agcaaacttc aaccctgatt tgacagacta ctaccttgag tctgtagatg
     7681 gaaaagttac ggcagtcaca gcaagtgtta gcaacaatgg cctcgctacc gtcgttccaa
     7741 gcgttcgtga aggtgagccg gttcgtgtca tcgcgaaagc tgaaaatggc gacatcttag
     7801 gagaataccg tctgcacttc actaaggata agaacttact ttctcataaa ccagttgctg
     7861 cggttaaaca agctcgcttg ctacaagtag gtcaagcact tgaattgccg actaaggttc
     7921 cagtttactt cacaggtaaa gacggctacg aaacaaaaaa cctgacagtt gaatgggaag
     7981 aagttccagc ggaaaatctg ataaaagcag gtcaatttac cgttcgaggc catgtccttg
     8041 gtagtgatct tgttgctgag gtcactgtac gagtgacaga caaactaggc gaagctcttt
     8101 cagataaccc taactatgat gaaaacagta accaggcctt tgcttcagca accaatgata
     8161 ttgacaaaaa ctctcatgac cgcgttgact atctcaatga cggagatcat tcagaaaatc
     8221 gtcgttggac aaactggtct ccaacaccat cttctaatcc agaagtatca gcgggtgtga
     8281 tcttccgtga aaatggtaag attgtagaac ggactgttgc tcaagccaaa cttcacttct
     8341 ttgcagatag tggtacggat gcaccaacta aactcgtttt agaacgctat gtcggtccag
     8401 agtttgaagt gccaacctac tattcaaact accaagccta cgacgcagac catccattca
     8461 acaatccaga aaattgggaa gctgtgcctt atcgtgcgga taaagacatc gcagctggtg
     8521 atgaaatcaa cgtaaccttt aaagctgtca aagccaaagc tatgagatgg cgtatggagc
     8581 gtaaagcaga taagagcggt gttgcgatga ttgagatgac cttcctggca ccgagtgaat
     8641 tgcctcaaga aagcacgcaa tcgaagattc ttgtagatgg aaaagaactt gctgatttcg
     8701 ctgaaaatcg tcaagactat caaattacct ataaaggtca acggccaaaa gtctcagttg
     8761 aagaaaacaa tcaagtagct tcaactgtgg tagatagtgg agaagatagc cttccagtac
     8821 ttgttcgcct cgtttcagaa agtggaaaac aagtcaagga ataccgtatc cagttgacta
     8881 aggaaaaacc agtttctgag aagacagttg ctgctgtaca agaagatctt ccaaaactcg
     8941 aatttgttga aaaagatttg gcctacaaga cagttgagaa aaaagattca acactgtatc
     9001 taggtgaaac tcgtgtagaa caagaaggaa aaactggtaa agaacgtatc tttacagcga
     9061 ttaatcctga tggaagtaag gaagaaaaac tccgtgaagt ggtagaagct ccgacagacc
     9121 gcatcgtctt ggttggaacc aaaccagtag ctcaagaagc taaaaaacca caagtgtcag
     9181 aaaaagcaga tacaaaacca attgattcaa gtgaagctag tcaaactaat aaagcccagt
     9241 taccaaatac aggtagtgcg gcaagccaag cagcagtagc agcaggttta gctcttctag
     9301 gtttgagtgc aggattagta gttactaaag gtaaaaaaga agactagaaa ttttgatacc
     9361 ttctttatca ttaaagacca aagaaaaact cttgtcctaa atagaagata aagagtctgg
     9421 aacaaaatag ttctcaacca caaaaaagct agatatttcc aattgcggaa ctctagcttt
     9481 ttaattttga gtcgttctct tattgtatag tagattgaaa ctagagtagt acacttctac
     9541 ttctaaaaca ttgttagaaa tcgatttgac tgtccttatc gatttgtcct gttcttattt
     9601 catttcacta tgttttagga ggttattggc cataagtacc aatcccatgt caattctcac
     9661 ttgacgcttg cctctcagat tacatctctt gtaacccaaa caagccttta tctgcccaaa
     9721 gacaggttct acatcaatct tgcgttgagc gaaaatctgt ctatcttggg gagataaaag
     9781 cgcctgacat tctttagctt tcaagttttg atagcgttcg ttcatataca atcccttttg
     9841 aggggctgat tcaggttcat cagcgtagta aaccttgatt tcctgttgaa agtctgtctg
     9901 tgttttctgg tacttgatat ggtgaaaacg atagcaccag ccatcaggat gtatgtagct
     9961 atcctccttg tcattatagt gccaattcgc taagttttta gctgactgtt tataccctct
    10021 cttttgttcc ttatcaaaca tggcatattt aatcagaagg ggagtgattt cttcttgaaa
    10081 atagacttgt atctgttctt gaagtttggc ggagaatttc tctgtcgttt tcttccacac
    10141 aaaactatac ttgttggcat tggattcaat cttagttccg tcaataaaca aacaatctaa
    10201 ggtcactaac tcttccattt ttcaattttt cgaccagaga aaatcccttg tgaataggca
    10261 aatagaagag tagatacaag cattttaggg tgataagacg ggcgaccaaa ggcatgatag
    10321 gaggtgtaga agtgacgttc ctccaaggta ttcaccactt tttcaatagt aaagacgaga
    10381 tggtcttgtg gtaagaagga actgatttct agtggtaaag ttgtttgatt tgtgttatag
    10441 tgaatatgca tgggatagcc tttctaaatg gtttattaag caattctatt ttaccaagac
    10501 tatcgtaacc atgcaaaaaa gcaacggcaa atccgttgcc ttttttggat ataagagact
    10561 attgtcccag actcttttct ttgtataaaa ttgtatagtg ttattgtcta tactattttg
    10621 tagagaaagc aaaaatccct agaaaatgct tagggattcg actatttcat taagaacaat
    10681 tcaacaatca tctctatata catgataagg gttaataaaa atcctgtacg ccagaagaat
    10741 ttgatgaatt taggatagta aaagctgcgt ttttttaaaa ggaagaaaaa gacgagaata
    10801 atggctagga acgagagggc tagccccagt ctagggagga aattatgggt aaaggtttta
    10861 gctgtaatca agtaatactc aaataccaag actggaaaag ccaaatccgc aaagtttcgt
    10921 cctagttttt ttaatctaaa aagtttggtt aggataatgc agacgactaa ggtcagtatc
    10981 aataataaaa tagatgctaa tttcattaaa atcataccca tattgtatca taaaaaaagg
    11041 ctaatggaaa cgagaaacag aggaatttat aggaaagtca ggcttttgag attgtgggtg
    11101 atttttgtta taatgaaagt tataaaatct tatgatacct tgaatgatta ttatcgaaaa
    11161 ctctttggag aaaagacttt taaagtccct attgatgcgg gatttgactg tcccaatcgt
    11221 gatggaactg tggctcatgg aggctgtact ttttgtacgg tttccggttc tggagatgcc
    11281 attgtagccc cagatccgcc tatccgtgag caattttata aggaaattga ctttattcat
    11341 cgtaagtggc cagatgttca gaagtatctg gtttattttc aaaattttac caacacccat
    11401 gaaaaggtgg aagttattcg agagcgttat gaacaggcta tcaatgagcc aggtgtggta
    11461 ggaatcaata ttggaacgcg cccagactgt ttaccagacg aaaccatcga atatttggct
    11521 gagttatcgg agtgcatgca tgtgacggtt gaattgggct tgcagactac ttatgaagca
    11581 acctctgacc tgattaaccg tgcgcattct tatgaattgt aggtggaaac ggtcaagcgt
    11641 ttgagaaagt atccaaaaat tgagattgtt tcccatttga tcaatggttt gcctggtgaa
    11701 acccatgaga tgatggttga aaatgtccgc cgttgtgtca cggataacga tattcaaggg
    11761 attaaactgc atttgctcca tcttatgaca aatactcgta tgcaacgaga ttaccatgag
    11821 ggacgtttac aattgatgag tcaggacgaa tatgtcaggg tcatctgtga ccaactggaa
    11881 attattccca aacatatcgt catccatcga attacaggag atgcgcctag ggatatgctg
    11941 attggtccta tgtggagcct caataaatgg gaagtcctca acagcattga gatggagatg
    12001 agacgtcgtg gaagtgttca aggatgcaag gctgtaaaac aggagtttga aaatgaaaag
    12061 accacttgag atggcacatg attttttggc tgaggtcgtg acaaaagagg atgtcgtagt
    12121 ggatgcgact atgggaaatg gtcatgacac gcttttttta gccaagctag ccaagcaagt
    12181 ctatgccttt gatattcaga agcaagcctt ggaaaagacc caagagcgtt tgcatcaggc
    12241 tggcttgaca aatgcccagt taatcttgca aggccatgag acactggacc agtttgtgac
    12301 aaaagctaag gcagggattt ttaatttggg ctatttgccg tcagctgata agtctgtcat
    12361 cacccgaccg cagacaacga ttgaggcatt agaaaagcta tgtggcttac ttgtcaaagg
    12421 tggacgaatt gctattatga tttactatgg tcatgaagga ggcgacctcg agagagatgc
    12481 tgtcttggat tttgtgatcc agttgaacca acaagagtac acagctgcca tttaccgaac
    12541 tttaaaccaa gtcaacaacc cgccgttttt agtgatgatt gaaaaattag agagatacag
    12601 acatggataa acaataccta cacgaaaagc tggatgccat gcgccagaat tttgttgaat
    12661 caacctacca cgaacgagcg gtgggcgtgc tagaccaagc gcatatgagc aaaaaaatgc
    12721 ttaaaatcaa gaaaaaatta gttgctcttg aaatggaacg gtgccagaga aaaattgagc
    12781 acaaagactg ttccaagatt gaccaaaaaa tcaaagagca gaaggagata tttgaatcct
    12841 gttgtaaaaa agattaagga ggacgtgcgt ggaattactg atttacctca tcctattttt
    12901 actggtcttg attgtctcaa gtacaaccaa taagctccta ccctttttgc ctctcccttt
    12961 ggtgcagatt cttttgggaa ttgtgattgg tctcttttta cccaatactg actttcacct
    13021 taatacggag ttgtttttgg cactggttat cggccccttg cttttccgag aggctgaaga
    13081 agcagatgtt acggctattt taaaacactg gcgaatcatt gtttatctca tatttccagt
    13141 gatttttatc tcgaccctga gtttgggtgg cttggcccat cttctttggt tcagccttcc
    13201 cttggcagct tgcttggctg ttggggcagc ccttggtcct acggacttgg tggcctttgc
    13261 ctctctttcg gagcgtttta gctttcctaa gcgcgtgtcc aatattctta agggcgaagg
    13321 actcttgaat gatgcttctg gtttggtggc ttttcaggta gctttgacag cttggacaac
    13381 tggagctttt tctctggggc aagctagcag ttcactcatc ttttcaatcc taggcggttt
    13441 tttaattgga tttttaacag ccatgaccaa ccgcttcctc cataccttct tgctaagtgt
    13501 gcgtgcaacg gatattgcca gtgaactttt attagaattg agtttgcctc ttgtgacctt
    13561 ctttctggca gaagaagttc atgtttcagg tattattgcc gtcgtagttg ctggaatttt
    13621 aaaggcaagt cgtttcaaga aaatcacgct cctcgaagcc caagtggata cggtgaccga
    13681 gacggtctgg catacagtga cctttatgct caacggttct gtctttgtga ttttagggat
    13741 ggagctggaa atgatagcag aacctatctt gaccaatcca atctataatc ctctactttt
    13801 attgctatct cttatcgccc ttacctttgt cctctttgtc attcgtttta ttatgatcta
    13861 tggctattat gcctatagaa cccgacgcct caagaaaaag ctaaataagt atatgaagga
    13921 catgtttctc ttgacctttt caggtgttaa gggaacggtg tcgattgcta cgattctctt
    13981 gataccaagt aatctagaac aggagtatcc tctcttgctt ttccttgttg caggtgtgac
    14041 gcttgttagc tttttaacag gtctcttggt cttgcctcat ctttctgatg aagaggaaga
    14101 aagcaaggat tatctcatgc atatcgccat tttgaatgaa gtaacgctag agttggaaaa
    14161 agagttggaa gacaccagaa ataaactttc cctctatgcg gctattgaca attatcatgg
    14221 acgtattgaa aatctcattt taagccaaga aaaccaggat gatcaagaag actgggctgc
    14281 tttgaaattc ttgattctta gtattgaaag tgatggtttg gaacaggcct atgaagaggg
    14341 gaatattagc aatcgtgctt accgagttta ccaacgttat ctgaaaaata tagaacaagg
    14401 aatcaatcgt aaacttgcct caagactgac ctattatttt cttgtttcct tgaggatttt
    14461 acgttttctc cttcatgaag tttttactct tggaaagacc ttccgtagct ggaaggacaa
    14521 ggagcaaagc cgtctccgtg ctcttgatta tgaccaaatt gcagagctct atcttgccaa
    14581 tacagagatg attattgaaa gtttggaaaa cctgaaggga gtctacagac gctctttgat
    14641 tagttttatg caggagtctc gtcttcgaga aacagctatt atcagcagtg gtgcctttgt
    14701 cgaacgggtt atcaatcgtg tcaaacccaa caatatcgat gaaatgctga gaggctatta
    14761 tctggagcgc aagttgattt tcgaatacga agaaaaacga ttaattacaa ctaagtatgc
    14821 caagaaatta cgacaaaatg taaataactt agagaactat tccttgaagg aagctgccaa
    14881 taccctgccg tatgatatgg tggaattggt aagaagaaat tagttaatac tcttcgaaaa
    14941 tctcttcaaa ccacgtcagc gtcgccttgg attatatatg tgactgactt cgtcagtttc
    15001 atctacaacc tcaaagcagg gctttgagca acctgcggct agcttcctag tttgctcttt
    15061 gattttcatt gagtataaga ttataaatga aggagtatga catgaaaaag tggtggaaag
    15121 agctgataga caagccttta ttaaaagctt ttttgcatta ttatcaagca tcagatagtg
    15181 agttgaccag tgtcgcagta gcctactatt ggttgatttc gattttcccc ctgcttttgg
    15241 tggtggtcaa tatcctcccc tattttcaga ttcctgtggg agaatttctg tgctttatga
    15301 aagacgtcct gcccccaagc ctctatgaag gtgtggaaaa aatagccaga gaagttttga
    15361 cgcaaccttc aacaggttta ttgagttttt ctgttttatc ggcgttatgg agtttttcaa
    15421 aatctatgaa tttcttgcaa aaagctttta acaaggctta tggcgtcgaa aagagtcgtg
    15481 gacttatttc ccatcagatg ctaagtctcc tagtcagttt tggcttgcag ctcctctttg
    15541 cgtttgcctt gtttttgatc ttatttggtc agatgatttt ggctttactt gctcattatt
    15601 ggacaaaaga tggcattatc tatcaggctt tacaagggtt ggcaggtcct ctgatttacg
    15661 ccctcctctt tgctatcttg gtcatgcttt attattttct tcccaatata tctaacagga
    15721 aaattagcta taccctacca ggcagtgcct ttgttctctt agtgatttta ggtttactaa
    15781 ctctgttctc tagttatctc aattactatg tccatcattt ggtggatgtc cgaattttag
    15841 gttccgttct tcttgttgtt atgatgtttt ggtttatctt gattgctaaa attgttatcc
    15901 taggcgcggt tatcaatgcc agtatgcaga gtttgagaga tccggtcttt aaaaaagact
    15961 aactatttat ccattacaaa agcgcatagt atcaaaactt tatagaacct tgatactatg
    16021 cgcttttgtg ctttgacagt tttttgtata gtttttgtcc aagatttcta aatcatctga
    16081 ttaaattcct attttcccct atcattgtcc ctgttttttc gaaaatggaa ggagtataat
    16141 aaatctatca ataaaatgat aggaggaact ttatgggtca tattttcttt tttctaagtg
    16201 tctttttggc agggattcta tccttctttt ctccttgtat cttacctttg ttaccggtct
    16261 atacaggagt gttactagat gataaggatg gtgctcaggc ttctagcggc aaattttcaa
    16321 tctcagttac tagtttatta cgaactctgg cctttatagc aggaatttcc tttatattta
    16381 ttttgttggg ctatggagct ggttttttag gcgatttgct ttatgcttct tggttccaat
    16441 atcttactgg ggcaattatt atccttcttg gtttgcacca aatggagatt ctacacttta
    16501 aggggcttta taaggaaaag aggctacaac tgcaaggaca ggggcaaaat ggtaagggct
    16561 atagtcaggc atttttattg ggcttgacct ttagttttgc ttggacgcct tgcgtggggc
    16621 cggttctggg gtctgttttg gccttggcgg cttcaggtgg ttcaggagct tggcagggag
    16681 ctggtctcat gttggtgtat acgctgggct tggcgctacc attcttgctt ctagctctga
    16741 cctctagtta tgttttgaaa catttccgaa aacttcatcc ctatctcgga atcctcaaaa
    16801 aagtgggtgg ttttctcatt attgtgatgg gactcttggt tctgtttgga aatgcttcaa
    16861 ttttaagtca attatttgaa taaaatggaa aggaatatca atatgaaaaa atggcaaaca
    16921 tgtgttcttg gagcaggttc gctcctttgt ttgacggctt gttcaggcaa gtccgtgact
    16981 agtgaacacc aaacgaaaga tgaaatgaag acggagcaga cagctagtaa aacaagcgca
    17041 gctaaaggga aagaggtggc tgattttgaa ttgatgggag tagatggcaa gacctaccgt
    17101 ttatctgatt acaagggcaa gaaagtctat ctcaaattct gggcttcttg gtgttccatc
    17161 tgtctggcta gtcttccaga tacggatgag attgctaaag aagctggtga tgactatgtg
    17221 gtcttgacag tagtgtcacc aggacataag ggagagcaat ctgaagcgga ctttaagaat
    17281 tggtataagg gattggatta taaaaatctc ccagtcctag ttgacccatc aggcaaactt
    17341 ttggaaactt atggtgtccg ttcttaccca acccaagcct ttatagacaa agaaggcaag
    17401 ctggtcaaaa cacatccagg attcatggaa aaagatgcaa ttttgcaaac tttgaaggaa
    17461 ttagcctagg aggtgtctta tgaatgataa gttaaaaatc ttcttgttgc taggagtatt
    17521 ttttctagcc ataaccggtt tctatgttct attgatacga aatgcagggc agacagatgc
    17581 ctcgcaaatt gaaaaggcgg cagttagcca aggaggaaaa gcagtgaaaa aaacagaaat
    17641 tagtaaagac gcagacttgc acgaaattta tctagctgga ggttgtttct ggggagtgga
    17701 ggaatatttc tcacgcgttc ccggggtgac ggatgccgtt tcaggctatg caaatggtag
    17761 aggagaaaca accaagtacg aattaattaa ccaaacaggt catgcagaaa ccgtccatgt
    17821 cacctatgat gccaagcaaa tttctctcaa ggaaatcctg cttcactatt tccgcattat
    17881 caatccaacc agcaaaaata aacaaggaaa tgatgtgggg acccagtacc gtactggtgt
    17941 ttattacaca gatgacaagg atttggaagt gattaaccaa gtctttgatg aggtggctaa
    18001 gaaatacgat caacctctag cagttgaaaa ggaaaacttg aagaattttg tggtggctga
    18061 ggattaccat caagactatc tcaagaaaaa tccaaatggc tactgccata tcaatgttaa
    18121 tcaggcggcc tatcctgtca ttgatgccag caaatatcca aaaccaagtg atgaggaatt
    18181 gaaaaagacc ctgtcacctg aggagtatgc agttacccag gaaaatcaaa cagaacgagc
    18241 tttctcaaac cgttactggg ataaatttga atccggtatc tatgtggata tagcaactgg
    18301 ggaacctctc ttttcatcaa aagacaaatt tgagtctggt tgtggctggc ctagttttac
    18361 ccaacccatc agtccagatg ttgtcaccta caaggaagat aagtcctaca atatgacgcg
    18421 tatggaagtg cggagccgag taggagattc tcaccttggg catgtcttta cggatggtcc
    18481 acaggacaag ggcggcttac gttactgtat caatagcctc tctatccgct ttattcccaa
    18541 agaccaaatg gaagaaaaag gctacgctta tttactagat tatgttgatt aatactcttc
    18601 gaaaatctct tcaaaccacg tcagcgtcgc cttaccgtat gtagggtt
//
LOCUS       DAVLHC010000039        15782 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.040, whole genome shotgun sequence.
ACCESSION   DAVLHC010000039 DAVLHC010000000
VERSION     DAVLHC010000039.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 15782)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15782)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15782
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.040"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            116..769
                     /locus_tag="VXE25_001569"
     CDS             116..769
                     /locus_tag="VXE25_001569"
                     /EC_number="3.2.2.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001841111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil-DNA glycosylase"
                     /protein_id="HEV0772006.1"
                     /translation="MEHSSWHALIKAQLPEGYFGKINQFMEQVYSQGIIYPPKEKVFQ
                     ALLTTLLEEVKVVILGQDPYHGPGQAQGLSFSVPDSIPAPPSLQNILKELSDDIGVKK
                     SHDLTAWAEQGVLLLNACLTVPAGQANGHAGQIWEPFTDAVIQVVNHLDRPVVFVLWG
                     AYARKKKALVTNPHHLIIESAHPSPLSVYRGFWGSKPFSKANAFLKETGQEPIDWLR"
     gene            779..1243
                     /locus_tag="VXE25_001570"
     CDS             779..1243
                     /locus_tag="VXE25_001570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003012002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="8-oxo-dGTP diphosphatase"
                     /protein_id="HEV0772007.1"
                     /translation="MPQLATICYIDNGKELLMLHRNKKPNDVHEGKWIGVGGKLERGE
                     TPQECATREILEETGLKAKPVLKGVITFPEFTPDLDWYTYVFKVTEFEGDLIDCNEGT
                     LEWVPYDEVLSKPTWEGDHTFVEWLLEDKPFFSAKFVYDGDKLLDTQVDFYE"
     gene            1256..2524
                     /locus_tag="VXE25_001571"
     CDS             1256..2524
                     /locus_tag="VXE25_001571"
                     /EC_number="3.5.2.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000924471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotase"
                     /protein_id="HEV0772008.1"
                     /translation="MLLIKNGRVMDPKSGLDQVCDVLVQDGKIIKIAPEITEEGAETI
                     DATGLVVAPGLVDIHVHFREPGQTHKEDIHTGALAAAAGGFTTVVMMANTSSTISDVE
                     TLQAVLQSAAKEKINVKTVATITKNFNGKNLTDFKALLEAGAVGFSDDGIPLESSKIV
                     KEAMEEAKKLNTFISLHEEDPGLNGVLGFNENIAREHFHICGATGVAEYAMMARDVMI
                     AYATKAHVHIQHLSKEESVKVVEFAQGLGAEVTAEVAPQHFSKTEALLLTQGSNAKMN
                     PPLRLESDRRAVIEGLKSGVITVIATDHAPHHVDEKNVEDITKAPSGMTGLETSLSLS
                     LTYLVEAGELSLMELLEKMTYNPAKLYNFEAGYLAENGPADITIFDAKADRFVDSHFA
                     SKAANSPFIGETLKGQVKYTICKGQIVYQA"
     gene            2538..2798
                     /locus_tag="VXE25_001572"
     CDS             2538..2798
                     /locus_tag="VXE25_001572"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772009.1"
                     /translation="MNYFRKRRERQAKSNSGIYCPAANRSKIQYETKEKADHAVQYDN
                     GGLVRSYYCRTCACWHTTSKSNKPPLSLKNYGLKLFGLDKSE"
     gene            2809..4170
                     /gene="pdrM"
                     /locus_tag="VXE25_001573"
     CDS             2809..4170
                     /gene="pdrM"
                     /locus_tag="VXE25_001573"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000278543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium-coupled multidrug efflux MATE transporter
                     PdrM"
                     /protein_id="HEV0772010.1"
                     /translation="MYKTKCLREKLVLFLKIFFPILIYQFANYSASFVDTAMTGQYNT
                     MDLAGVSMATSIWNPFFTFLTGIVSALVPIIGHHLGRGKKEEVASDFYQFIYLALGLS
                     VVLLGMVLFLAPIILNHIGLEAAVAAVAVRYLWFLSIGIIPLLLFSVIRSLLDSLGLT
                     KLSMYLMLLLLPLNSGFNYLLIYGAFGVPELGGAGAGLGTSLAYWVLLGISVLVLFKQ
                     EKLKALHLEKRIPLNMDKIKEGVRLGLPIGGTVFAEVAIFSVVGLIMAKFSPLIIASH
                     QSAMNFSSLMYAFPMSISSAMAIVVSYEVGAKRFDDAKTYIGLGRWTALIFAAFTLTF
                     LYIFRGNVASLYGNDPKFIDLTVRFLTYSLFFQLADTFAAPLQGILRGYKDTVIPFYL
                     GLLGYWGVAIPVATLFDSLTDFGAYSYWIGLIISLIVSGALYRWRLTVIMKRFESLAK
                     SKC"
     gene            4324..5292
                     /locus_tag="VXE25_001574"
     CDS             4324..5292
                     /locus_tag="VXE25_001574"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844850.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine pyrophosphate-dependent dehydrogenase
                     E1 component subunit alpha"
                     /protein_id="HEV0772011.1"
                     /translation="MSTLDKNLLLEMFRKMEEIRRMDLKIAQLVKKGKVPGMTHFSVG
                     EEAANVGAMLALNPDDLITSNHRGHGQAIAKGIDLNGMMAEILGKYTGTCKGKGGSMH
                     IADLDAGNLGANGIVGGGMGIAVGAALSQQMQNTGKIVVCFFGDGATNEGVFHEAVNM
                     ASIWNLPVIFYCINNGYGISADIKKMTNIEHIHQRSAAYGIPGMFIEDGNNVIDVYEG
                     FQKAVDHVRSGNGPVLIESVTYRWLGHSSSDPGKYRTREEVELWKQKDPIENLRNYLI
                     ENNIASAEELEEIQAQVKEAVEASVKFAEESPFPPLESAFEDIYAD"
     gene            5308..6300
                     /locus_tag="VXE25_001575"
     CDS             5308..6300
                     /locus_tag="VXE25_001575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000448722.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-ketoacid dehydrogenase subunit beta"
                     /protein_id="HEV0772012.1"
                     /translation="METKTMSFRDTIILAMSEEMRRDENVFLMGEDVGVFGGDFGTSV
                     GMLEEFGPERVRDCPISEAAISGAAAGAAMTGLRPIVDMTFMDFSVIAMDNIVNQAAK
                     TRYMFGGKGQVPMTVRCAAGNGVGSAAQHSQSLESWFTHIPGLKVVAPGTPADMKGLL
                     KSSIRDNNPVIILEYKSEFNQKGEVPVDPDYTIPLGVGEIKRQGTDVTVVTYGKMLRR
                     VVQAAEELAEEGISVEIVDPRTLVPLDKDIIINSVKKTGKVVLVNDAHKTSGYIGEIS
                     AIISESEAFDYLDAPIRRCAGEDVPMPYAQNLENAMIPTVESIKDAIRKTYNKD"
     gene            6518..7561
                     /locus_tag="VXE25_001576"
     CDS             6518..7561
                     /locus_tag="VXE25_001576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrolipoamide acetyltransferase"
                     /protein_id="HEV0772013.1"
                     /translation="MADDKLRATPAARKLADDLGINLYDVSGSGANGRVHKEDVETYK
                     DTNVVRISPLAKRIALEHNIAWQEIQGTGHRGKIMKKDVLALLPENIENDSIKSPAQI
                     EKVEEVPDNVTPYGEIERIPMTPMRKVIAQRMVESYLTAPTFTLNYEVDMTEMLALRK
                     KVLEPIMEATGKKTTVTDLLSLAVVKTLMKHPYINASLTEDGKTIITHNYVNLAMAVG
                     MDNGLMTPVVYNAEKMSLSELVVAFKDVIGRTLDGKLAPSELQNSTFTISNLGMFGVQ
                     SFGPIINQPNSAILGVSSTIEKPVVVNGEIVIRPIMSLGLTIDHRVVDGMAGAKFMKD
                     LKELIETPISMLI"
     gene            7625..9310
                     /gene="lpdA"
                     /locus_tag="VXE25_001577"
     CDS             7625..9310
                     /gene="lpdA"
                     /locus_tag="VXE25_001577"
                     /EC_number="1.8.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrolipoyl dehydrogenase"
                     /protein_id="HEV0772014.1"
                     /translation="MPKAGVDMTEGQIVQWNKKVGEFVKEGEILLEIMTDKVSMELEA
                     EEDGYLIAILKGDGETVPVTEVIGYLGEERENIPTAGAASPEASPVPVASTSNDDGKS
                     DDAFDIVVIGGGPAGYVAAIKAAQLGGKVALVEKSELGGTCLNRGCIPTKTYLHNAEI
                     IENIGHAANRGIVIENPNFTVDMEKLLETKSKVVNTLVGGVAGLLRSYGVTVHKGIGT
                     ITKDKNVLVNGSELLETKKIILAGGSKVSKINVPGMESPLVMTSDDILEMNEVPESLV
                     IIGGGVVGIELGQAFMTFGSKVTVIEMMDRIVPAMDAEVSKNLRLILERKGMTILTGT
                     KLQEIIEENGQLRIKVEGKDDIIASKALLSIGRMPDLEGIGEVEFELDRGCIKVNEYM
                     ETSVPGIYAPGDINGTKMLAHAAFRMGEVSAENALKGNHAVAKLNLTPAAIYTLPEVA
                     AVGLTEEQAREKYDVAIGKFNFAANGRAIASDAAQGFVKVIADKKYGEILGVHIIGPA
                     AAELINEASSIIEMEITVEEMLKTIHGHPTYSEVMYEAFADVLGMAIHSPKKK"
     gene            9374..10363
                     /locus_tag="VXE25_001578"
     CDS             9374..10363
                     /locus_tag="VXE25_001578"
                     /EC_number="6.3.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000873976.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoate--protein ligase"
                     /protein_id="HEV0772015.1"
                     /translation="MKYIINHSNDTAFNIALEEYAFKHLLDEDQIFLLWINKPSIIVG
                     RHQNTIEEINRDYVRENGIEVVRRISGGGAVYHDLNNLNYTIISKEDENKAFDFKSFS
                     TPVINTLAQLGVKAEFTGRNDLEIDGKKFCGNAQAYINGRIMHHGCLLFDVDLSVLAN
                     ALKVSKDKFESKGVKSVRARVTNIINELPKKITVEKFRDLLLEYMKKEYPEMTEYVFS
                     EEELAEINHIKDTKFGTWDWNYGKSPEFNVRRGTKFTSGKVEVFANVTESKIQDIKIY
                     GDFFGIEDVAAVEDVLRGVKYEREDVLKALKTIDITRYFAGISREEIAEAVVG"
     gene            complement(10434..11504)
                     /gene="xerS"
                     /locus_tag="VXE25_001579"
     CDS             complement(10434..11504)
                     /gene="xerS"
                     /locus_tag="VXE25_001579"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000817875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine recombinase XerS"
                     /protein_id="HEV0772016.1"
                     /translation="MKREILLERIDKLKQLMPWYVLEYYQSKLAVPYSFTTLYEYLKE
                     YDRFFSWVLESGISNADKISDIPLSALENMSKKDMESFILYLRERPLLNANTTKQGVS
                     QTTINRTLSALSSLYKYLTEEVENDQGEPYFYRNVMKKVSTKKKKETLAARAENIKQK
                     LFLGDETEGFLTYIDQEHPQQLSNRALSSFNKNKERDLAIIALLLASGVRLSEAVNLD
                     LRDLNLKMMVIDVTRKGGKRDSVNVAAFAKPYLENYLAIRNQRYKTEKTDTALFLTLY
                     RGVPNRIDASSVEKMVAKYSEDFKVRVTPHKLRHTLATRLYDATKSQVLVSHQLGHAS
                     TQVTDLYTHIVNDEQKNALDSL"
     gene            complement(12079..13629)
                     /locus_tag="VXE25_001580"
     CDS             complement(12079..13629)
                     /locus_tag="VXE25_001580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000392528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chloride channel protein"
                     /protein_id="HEV0772017.1"
                     /translation="MEEQSEIVRSKKEFAFASSTILSQVGRGIIVGLIVGIIVGSFRF
                     LIEKGFHLIQGVYQDQGYLVRNLFVLVLFYILICWLSAKLTRSEKDIKGSGIPQVEAE
                     LKGLMSLNWWGILWKKYVLGILAIASGLMLGREGPSIQLGAVGGKGIAKWLKSSPVEE
                     RSLIASGAAAGLAAAFNAPIAALLFVVEEVYHHFSRFFWVSTLAASIVANFVSLLMFG
                     LTPVLDMSDNIPPMTLDQYWIYLVMGIFLGFSGFLYEKAVLNVGRVYDLIGQKIHLDR
                     AYYPILAFILIIPVGIFLPQILGGGNQLVLSLTEQNFSFQVLLAYFLIRFIWSMISYG
                     SGLPGGIFLPILALGSLLGALVGVICVNLGLVSQEQFPIFVILGMSGYFGAISKAPLT
                     AMILVTEMVGDIRNLMPLGLVTLVSYIIMDLLKGTPVYEAMLEKMLPEEVSSEGEVTL
                     IEIPVSDKIAGKQVHELNLPHNVLITTQVHNGKSQTVNGSTRMYLGDMIHLVIPKSEI
                     GKVKDLLL"
     gene            complement(13645..14424)
                     /locus_tag="VXE25_001581"
     CDS             complement(13645..14424)
                     /locus_tag="VXE25_001581"
                     /EC_number="3.1.26.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000201102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease HII"
                     /protein_id="HEV0772018.1"
                     /translation="MATIKEIKELLVTVKELESPIFLDLEKDNRSGVQKEISKRKRAI
                     QAELDENLRLESMLSYEKELYKQGLTLIAGIDEVGRGPLAGPVVAAAVILPKNCKIKG
                     LNDSKKIPKKKHLEIFQAVQDQALSIGIGIIDNQVIDQVNIYEATKLAMQEAISQLSP
                     QPEHLLIDAMKLDLPISQTSIIKGDANSLSIAAASIVAKVTRDELMKEYDQQFSGYDF
                     ATNAGYGTAKHLEGLTKLGVTPIHRTSFEPVKSLVLGKKES"
     gene            complement(14411..15262)
                     /gene="ylqF"
                     /locus_tag="VXE25_001582"
     CDS             complement(14411..15262)
                     /gene="ylqF"
                     /locus_tag="VXE25_001582"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000201313.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase YlqF"
                     /protein_id="HEV0772019.1"
                     /translation="MATIQWFPGHMSKARRQVQENLKFVDFVTILVDARLPLSSQNPM
                     LTKIVGDKPKLLILNKADLADPAMTKEWRQYFESQGIQTLAINSKEQVTVKVVTDAAK
                     KLMADKIARQKERGIQIETLRTMIIGIPNAGKSTLMNRLAGKKIAVVGNKPGVTKGQQ
                     WLKTNKDLEILDTPGILWPKFEDETVALKLALTGAIKDQLLPMDEVTIFGINYFKEHY
                     PEKLAERFKQMKIEEEAPVIIMDMTRALGFRDDYDRFYSLFVKEVRDGKLGNYTLDTL
                     EDLDGND"
BASE COUNT         4653 a         3050 c         3394 g         4685 t
ORIGIN      
        1 tcacgtattc aaatcgtata tagtcgattt attaaatctt tagataaatt gtaaaaagtg
       61 gtttccatag ccactttttg ctataataga ggcagtaaaa atgaaggagt cagctatgga
      121 acactcgtct tggcatgctt tgattaaggc gcaattacct gagggttatt tcgggaaaat
      181 caatcagttt atggagcagg tctattctca ggggattatt tatccaccca aggaaaaggt
      241 ttttcaggct ctcttgacaa cactgcttga agaagttaag gtggtaattc tagggcaaga
      301 cccctatcac ggaccaggtc aagcgcaggg cttgagtttt tctgtacctg actctatccc
      361 agctccacca tccttgcaaa atatcttgaa agaattgtca gatgatatcg gagttaagaa
      421 atctcatgat ttgacagctt gggctgagca aggagtcttg cttcttaatg cttgtttgac
      481 tgttcctgct ggacaggcca atggtcatgc tggtcaaatc tgggagcctt ttactgatgc
      541 tgtgattcag gtggtcaatc atctagatag accagtcgtt tttgtactct ggggagctta
      601 tgcacgtaag aagaaggcct tagttaccaa tcctcatcac ttgattatcg aatcagccca
      661 tccaagtcct ttgtcggttt atagaggatt ttggggttcc aagccctttt ccaaggccaa
      721 tgcattctta aaagagacag gacaagagcc aatcgattgg cttagataag gagaaaatat
      781 gcctcagtta gcgacgattt gctacattga taatgggaaa gaactgctca tgctccatcg
      841 taataagaaa cccaatgatg tccatgaagg gaaatggatt ggtgtgggtg gtaagctaga
      901 gagaggagag acgccccagg aatgcgcgac gcgtgaaatc cttgaagaaa cagggctcaa
      961 agccaagcca gttctaaaag gtgtcatcac ttttcctgaa tttacaccag atttagactg
     1021 gtacacctat gtttttaagg tgacggagtt tgagggcgac ttgattgact gcaatgaggg
     1081 gacgctagaa tgggttccct atgatgaggt tttgagcaag ccgacttggg aaggtgacca
     1141 cacctttgtt gagtggcttt tagaggataa acccttcttt tcagccaagt ttgtttatga
     1201 tggggataaa ttgttggata cccaagttga tttctatgaa taaaggagaa agcagatgct
     1261 actaatcaaa aatggtcgtg taatggatcc caagtctggt ttggatcaag tttgtgatgt
     1321 cttagttcaa gatgggaaaa ttatcaaaat tgcgcctgag atcacggaag aaggagcaga
     1381 aacgattgat gctactggtc ttgtggttgc tcctggtttg gtcgatattc atgtgcattt
     1441 ccgtgaacct ggtcaaacac ataaagaaga cattcatact ggtgccctag cagccgctgc
     1501 aggtggtttt actactgtcg tcatgatggc taataccagt tcaaccattt cagacgtgga
     1561 gactttgcaa gcagttctcc agtcagctgc caaagagaag attaatgtca agacagttgc
     1621 gaccattact aaaaacttta atggtaaaaa cttgactgac tttaaggcac tcttagaagc
     1681 tggtgcggtt ggtttctctg atgacggtat tccgcttgag agcagtaaga ttgtcaagga
     1741 agccatggag gaagccaaaa aactcaatac ctttatcagc cttcatgagg aagatccagg
     1801 tttgaacggt gttcttggct ttaatgaaaa tattgctaga gaacatttcc atatctgcgg
     1861 tgctactggg gtggctgagt acgctatgat ggcgcgtgat gtcatgattg cctatgcaac
     1921 taaagcccat gttcacatcc agcatttgtc taaggaagaa agtgttaaag tagtggagtt
     1981 tgctcagggg ttaggtgcag aagtcacagc agaagtagcg ccacagcatt tctctaagac
     2041 agaagcactt cttttaacac aaggtagcaa tgctaagatg aatccaccgc ttcgtttgga
     2101 atcagaccgt cgtgccgtta tcgaaggtct caaatcaggt gtcatcacag ttattgcgac
     2161 tgaccacgcg cctcatcatg tagatgaaaa aaatgttgag gatattacca aagcgccatc
     2221 tggtatgact ggcttagaaa catccctgtc tctcagcttg acctatttag tagaagctgg
     2281 tgagttgagc ttgatggaat tacttgaaaa aatgacatac aacccagcca agctttacaa
     2341 ctttgaagca ggttacttgg ctgagaatgg tccagcagat atcactattt ttgatgccaa
     2401 ggctgaccgc tttgtggact cccattttgc ttccaaagca gctaattcac cattcatcgg
     2461 tgaaacctta aaagggcagg ttaaatatac catctgtaag ggacaaatcg tctatcaagc
     2521 ttgataggag ttagaatatg aattattttc gaaaacgtag ggagagacaa gcgaaatcta
     2581 atagtggaat ttactgtccc gcagctaatc gttccaaaat tcaatatgaa actaaagaaa
     2641 aagctgacca tgcggttcaa tatgataacg gaggtttagt tagaagctat tattgtcgta
     2701 catgtgcgtg ttggcatact acttcaaaat ctaataaacc tccgctaagt ttgaaaaact
     2761 atggtctgaa actctttggt ttagataaat cagaatagaa agagaagtat gtataagaca
     2821 aagtgtttac gagagaagtt agtattattt ttaaaaattt tcttcccaat cctgatctac
     2881 caatttgcca attattctgc ctcttttgtt gatactgcaa tgacaggtca atacaacact
     2941 atggacttgg ctggtgtatc tatggcaacc agtatctgga atcctttctt tacatttcta
     3001 acagggattg tgtcagcctt ggtgcctatc attggtcacc atcttggtcg aggcaaaaag
     3061 gaagaagttg cgtctgattt ttaccaattt atttatttgg ccttgggcct atctgtggtc
     3121 ttgctgggga tggtactttt cttggcacca ataatcttga atcatattgg gttagaagca
     3181 gcagtagcgg cagtagcggt tcgctatctt tggtttttat ctatcgggat tatccccttg
     3241 ttgctcttta gcgtcattcg ttccttgctg gattcgctgg gcttgaccaa actgtccatg
     3301 tacctcatgc ttttgttact ccctctcaat agcggattta actatctctt gatttacggt
     3361 gcctttggtg ttccagaact gggaggggct ggtgctggtt taggaacatc cttggcctac
     3421 tgggtcttgc ttgggatttc tgttctggtt ttatttaaac aggagaagct caaagcctta
     3481 caccttgaga aacgaattcc acttaatatg gataaaatta aggaaggagt tcgtttaggt
     3541 ctgcctattg ggggaactgt cttcgcggaa gtggctatct tttcagtggt tggcttgatt
     3601 atggctaagt tttcgccctt gattatagct agtcaccagt cagctatgaa cttttcaagt
     3661 cttatgtacg cctttcctat gagtatctca tcggctatgg ctattgtcgt ttcctatgaa
     3721 gtgggagcca agcgatttga tgatgcgaaa acctatattg gtctaggaag atggactgcc
     3781 ctcatttttg cggccttcac cttaaccttc ctttacattt ttaggggaaa tgtggccagt
     3841 ctttatggta acgacccaaa atttatcgat ttgacagtgc gttttttaac ttatagtctt
     3901 ttcttccagt tagcagatac ctttgcggcg ccgcttcagg gaattttgcg ggggtataag
     3961 gatacagtta ttccttttta ccttggtttg cttggttatt ggggcgtagc aatccctgtg
     4021 gctacgctat ttgattccct aacagatttt ggagcttatt cttactggat cggcttgatt
     4081 attagtttga ttgtgagcgg ggcgctctac cgttggcgtt taactgtgat tatgaagaga
     4141 tttgaatctt tagcaaaatc caaatgctaa aaagtttgtg aaaaaatatt cttgacaaga
     4201 aaatcccttg ttttcacggg gttttctttt ttattttgtg aaatttcttt tagaaaaact
     4261 ttgacagtat ttgccaaaag cggtaaaata gtaaggtaag aagaaagtta gaaaggcaag
     4321 aagatgtcaa ctttagataa aaatcttttg ctagaaatgt tccgtaagat ggaagaaatc
     4381 cgtcgcatgg acttaaaaat tgcacaatta gtaaagaaag ggaaagtgcc aggaatgacg
     4441 cacttttctg ttggtgaaga ggcagctaac gtgggggcta tgttagctct caatccagat
     4501 gatctgatta cctcaaacca ccgtggacac gggcaagcta ttgctaaagg gattgacctc
     4561 aacggaatga tggctgaaat ccttggtaaa tacactggaa cctgtaaagg gaaaggtgga
     4621 tctatgcata tcgctgacct tgatgctggg aaccttggtg ccaatggtat cgtaggtggt
     4681 ggtatgggga tcgctgtcgg tgcagccctc agtcagcaaa tgcaaaatac cggtaaaatc
     4741 gttgtctgct tctttggaga tggtgcgacc aatgaaggtg ttttccacga agcagtgaac
     4801 atggcttcta tctggaacct gccagtcatt ttctattgca ttaacaacgg ttacggtatc
     4861 tctgcggata tcaagaaaat gaccaatata gaacatatcc atcaacgtag cgccgcttat
     4921 ggaattcctg gaatgttcat cgaagacggt aacaatgtca tcgatgtcta tgaaggattt
     4981 cagaaagctg tggaccatgt tcgcagtggc aatggtccag tcttgattga aagtgtaact
     5041 tatcgctggc tcggtcactc atcatctgac cctggtaaat atcgtacgcg tgaagaagtg
     5101 gaattgtgga aacaaaaaga tccaatcgaa aacctccgca attaccttat tgaaaataac
     5161 attgcaagtg ccgaagaatt ggaagaaatc caagcgcaag taaaggaagc agtagaagct
     5221 tctgttaaat ttgcagagga aagcccattc ccaccgcttg aatcagcctt tgaagatatt
     5281 tacgcagact aaggagaaag agataaaatg gaaacaaaaa caatgtcctt ccgtgacacc
     5341 attatccttg ctatgtctga ggaaatgcgt cgcgatgaaa atgtgttctt gatgggagaa
     5401 gacgtcggtg tcttcggagg agacttcggt acttctgttg gaatgcttga agaatttggt
     5461 ccagaacgtg tccgtgactg tccgatttct gaagctgcca tctctggagc agcagcagga
     5521 gcagccatga caggacttcg tccaatcgtc gatatgacct tcatggactt ctctgttatt
     5581 gccatggaca atatcgtcaa ccaagctgct aaaacacgtt acatgtttgg tggtaaaggt
     5641 caggttccaa tgactgttcg ttgtgcagct ggtaacggag ttggctctgc cgcccagcac
     5701 tcacaatctc tagagtcttg gtttactcac attccaggac ttaaggttgt ggcacctgga
     5761 acacctgcgg acatgaaagg cctgcttaag tcttctatcc gtgataacaa cccagttatt
     5821 atacttgagt acaagtcaga atttaaccaa aaaggggaag tgccagttga tccagactac
     5881 acaattccac ttggggttgg tgaaatcaaa cgccaaggga cggatgtaac agttgttact
     5941 tatggaaaaa tgcttcgccg tgtggttcaa gctgctgaag aattagcaga agaaggaatt
     6001 tcagttgaaa ttgttgaccc acgtaccctt gttccgcttg ataaggatat catcataaac
     6061 tcagtgaaga agactggtaa ggttgttctg gtcaacgatg cccacaaaac aagtggctat
     6121 atcggtgaaa tttcagctat tatttcagaa tcagaagcat ttgactatct agatgcacca
     6181 atccgccgtt gtgcaggaga agatgtgccg atgccttatg cacaaaacct agaaaatgca
     6241 atgattccaa cagttgaaag tatcaaagat gcaatccgaa aaacttataa caaagactag
     6301 agttacataa gataagttat gtaaataaaa caaagctgac gagaaacttt gtatctttta
     6361 ggtgcagagc tcttcgtcat taatatctta gattagagca cgggctaaaa gctcggaaaa
     6421 aagataaatc tccttggctt catcgaagcc atcgtcgatt tcctattttt cagtcgcttt
     6481 tgacgccctt tgtatcataa atagaattgg agaggtcatg gctgatgaca agctaagagc
     6541 gactcctgca gctagaaagt tagcggatga tttagggata aacctctacg acgtttctgg
     6601 ctcaggtgca aacggtcgtg tccacaaaga agacgtggaa acttataaag acacaaacgt
     6661 ggttcgcatt tcgccacttg caaaacgaat tgccctcgaa cataacattg cttggcagga
     6721 aatccaagga accggtcatc gtggtaaaat catgaagaag gatgttttgg ccctgcttcc
     6781 tgaaaatatc gaaaacgata gcatcaaatc tcctgctcag attgaaaaag tggaagaagt
     6841 ccctgataac gtaacaccat atggtgaaat cgagcgtatt ccaatgacac caatgcgtaa
     6901 ggttattgcc caacgcatgg ttgaatctta cttgactgcg ccaaccttca ccctaaacta
     6961 tgaagttgat atgactgaaa tgttggctct tcgtaagaag gttcttgagc caatcatgga
     7021 agcaactggg aagaagacta ctgtaacaga ccttctttca cttgcagttg ttaagactct
     7081 tatgaaacac ccatacatca acgcttcatt gacagaagat ggcaagacta ttatcactca
     7141 caactatgtc aatcttgcca tggcagttgg gatggataat ggattgatga cacctgttgt
     7201 ttacaatgct gagaagatga gtctttcaga actggttgta gcctttaagg atgttattgg
     7261 tcgtaccttg gatggtaaat tggctccaag tgagttacaa aattcaacat tcacaatcag
     7321 taatttggga atgtttggtg ttcagtcctt tggtccgatt attaaccaac ccaactcagc
     7381 tatccttggt gtcagttcga caatcgagaa gccagttgtc gtcaatggtg aaattgtgat
     7441 tcgcccaatc atgagtttag gattaaccat tgaccaccgt gtcgtagatg gtatggctgg
     7501 tgctaagttt atgaaggact tgaaagagtt gattgaaacg ccaatctcaa tgttaattta
     7561 agagcaagag tattcatttt taagatatag ataaaggaag gaagacatgg ccttagaagt
     7621 aattatgcca aaagccggcg tggatatgac agaaggacaa atcgtccaat ggaataaaaa
     7681 agtcggagaa tttgtaaaag aaggagaaat ccttttggaa atcatgactg ataaagtcag
     7741 catggaattg gaagccgaag aagatgggta cttgattgcc attctcaaag gagatggtga
     7801 aactgtccct gtaacggaag ttatcggtta ccttggtgaa gaaagggaaa acatcccaac
     7861 agctggagca gcatcgccag aagctagccc tgtacctgta gcaagtacct caaacgatga
     7921 tggtaagagc gatgatgctt ttgatatcgt tgtgattggt ggaggtcctg ctggttatgt
     7981 tgcagccatt aaagctgccc aactcggcgg taaggttgcc cttgttgaga aatctgaact
     8041 tggtggaacc tgcttaaacc gtggatgtat tccaaccaag acctaccttc ataacgctga
     8101 aattattgaa aatatcggtc atgctgcaaa tcgtggtatc gtgattgaaa atcctaactt
     8161 cactgttgat atggaaaaac ttttagaaac taaatctaaa gttgttaata ctcttgttgg
     8221 tggtgttgca ggacttcttc gtagctacgg agttactgtt cataaaggaa ttggtacaat
     8281 cactaaagac aagaacgtct tggtaaatgg ttctgaattg cttgaaacca agaaaatcat
     8341 tcttgctggt ggttcaaaag ttagcaagat caacgtccct ggtatggaat ctccacttgt
     8401 catgactagt gatgacattc ttgaaatgaa cgaagtgcca gaaagccttg ttatcatcgg
     8461 tggtggagtt gtcggtatcg aactcggtca ggccttcatg acgtttggtt caaaagtgac
     8521 tgttatcgaa atgatggacc gtatagttcc agctatggat gcggaagttt ctaagaacct
     8581 tcgcttgatc cttgagcgta aaggaatgac catcttgact ggtactaaac tgcaagaaat
     8641 cattgaggaa aatggtcaac ttcgtatcaa ggttgaagga aaagacgata tcatagcaag
     8701 caaagctctt ctttcaattg gtcgtatgcc agaccttgaa ggtattggag aggttgagtt
     8761 tgaattggat cgtggttgta tcaaggtcaa tgaatacatg gaaacttcag ttccaggcat
     8821 ttatgcacca ggtgacatca acggtactaa gatgttggct cacgcagctt tccgcatggg
     8881 tgaagtttcc gctgaaaatg cccttaaagg aaatcatgca gttgccaaat tgaatttgac
     8941 tcctgcagcc atctacactc tccctgaagt agcagcagta ggtttgacag aagaacaagc
     9001 ccgtgagaaa tacgatgttg ccatcggtaa gtttaacttt gctgctaatg gtcgtgctat
     9061 tgcatctgac gcagctcaag gtttcgtaaa agttatcgct gataagaaat acggagaaat
     9121 ccttggtgta cacattattg gtcctgcagc cgcagaatta ataaacgaag catcaagcat
     9181 catcgaaatg gaaatcactg ttgaggaaat gctgaagacc atccacgggc acccaactta
     9241 ctctgaagtg atgtacgaag cgtttgcaga tgttctagga atggccatcc attcacctaa
     9301 gaaaaaataa aacgaagata gattagactg gaaggttatt tccagtttct atcatataaa
     9361 gtaaagggat atcatgaaat acattatcaa tcattcaaat gacactgctt ttaatattgc
     9421 cttggaagaa tacgccttta aacacctttt ggatgaggat caaatcttcc tactttggat
     9481 taacaagcca tctatcattg ttggtcgtca ccagaacact atcgaagaaa tcaaccgtga
     9541 ttatgttcgc gaaaatggta ttgaggtagt tcgccgtatt agtggtggtg gagctgttta
     9601 ccacgattta aataacctca actacacgat catctccaaa gaagatgaaa ataaggcatt
     9661 tgacttcaag agcttctcaa ctccggttat caataccctg gctcaacttg gggttaaagc
     9721 tgagttcaca ggtcgtaatg accttgagat tgatggtaag aagttctgtg gtaatgccca
     9781 agcctatatc aacggccgta tcatgcacca cggttgcttg ctctttgacg ttgatttgtc
     9841 agtcctcgca aatgccctta aggtttcaaa agataaattt gaatcaaaag gtgtgaaatc
     9901 cgtccgtgcc cgtgtaacca atattatcaa tgaattacca aaaaaaatca cagtcgaaaa
     9961 attccgtgat ttactcttgg aatacatgaa aaaagagtac ccagagatga ctgaatacgt
    10021 cttttcagaa gaagaattgg ccgaaatcaa tcacatcaag gatactaagt ttggaacttg
    10081 ggactggaac tatggtaaat cacctgaatt taacgtccgt cgtggaacca aattcactag
    10141 tggtaaggtt gaagtctttg ctaacgttac tgaatcaaaa atccaagaca tcaagattta
    10201 tggtgacttc tttggtattg aagacgttgc tgcagtagaa gatgtccttc gtggggtgaa
    10261 atacgaacgc gaagatgttc ttaaggcgct aaaaaccatt gatatcacac gctacttcgc
    10321 tggtattagc cgtgaagaaa tcgctgaagc ggtagttgga taaatcaaaa agaagttggc
    10381 caactaacca acttcttttt gatatttatt tacataattt aaaatacgta aaattataaa
    10441 ctatctagag cattcttttg ttcatcatta acaatatggg tatagaggtc agtgacttgt
    10501 gtgctggcat gtcctagttg gtgactgact aaaacttgtg atttagtcgc atcatagagc
    10561 ctagttgcta gcgtatggcg cagtttatgg ggtgttacac gcactttaaa atcctctgag
    10621 tatttagcaa ccattttctc aacgctagaa gcatcgatac gattaggaac acctctgtag
    10681 agagttaaaa aaagggctgt atctgttttt tccgttttat agcgttgatt ccgaatggcc
    10741 agataattct ctaaataagg tttagcaaaa gcagcgacat tgactgagtc acgtttgcca
    10801 ccttttcgag taacatcaat aaccatcatt tttagattga gatctcttag atctagatta
    10861 acagcttcag ataagcgaac accagatgcc aagagaaggg caataatggc taaatctcgt
    10921 tctttatttt tgttgaatga tgagagagct cgatttgaaa gctgttgtgg gtgctcttga
    10981 tcgatataag ttagaaaacc ttctgtttca tcacctagaa agagtttttg cttgatattt
    11041 tcagctctgg cagcaagggt ttctttcttt ttcttggttg aaactttttt cattacatta
    11101 cgatagaaat aaggttcccc ctgatcgttt tcaacctcct cggttagata cttgtaaaga
    11161 ctagaaagtg ctgataaggt tcgattgata gttgtctgtg aaacaccttg ttttgttgta
    11221 ttagcattca gcaagggacg ttcacgtaga taaaggataa aggattccat gtctttctta
    11281 gacatatttt ccaaagctga taaaggaata tcggatattt tatcagcgtt tgaaatacca
    11341 gactccaaaa cccagctgaa aaatcggtca tattccttaa ggtattcgta cagggttgta
    11401 aaactgtagg gtacagccag cttagattgg tagtattcca gaacatacca gggcatgagt
    11461 tgttttagtt tgtcgattcg ttccagtaaa atctcacgtt tcatgtattt tctccataag
    11521 taagtatact agtagtatag catagacttg tatatttttc aagaaaatta tagtttttca
    11581 gaaagatgtt ataggagttt ttcaaagtga taaaaagact tagacctaca aacaaaacag
    11641 aataaggaaa atctcaccca ctaaacttct gttaatacta cataactgaa gagctatata
    11701 aggagctatg agatacaaaa cacattgtat aatagattga aactagaata gtacatctgg
    11761 acttctaaaa cattgctaga aattgatttg attgtcctga ttgttttatc ctatttctat
    11821 ttcatttcac tatataattg ctattgtttt ctttttcatg attttaatct tactgtacag
    11881 atttgataca gtaaactcct ttccagcttt atgctttatc atttctaact taattatagt
    11941 cttattttta ataaagttca attatttata tgtaaaattc ctcatcagta aaaaataacc
    12001 gatctcattt ctgagaatcg gttttctaaa taaatcaaac tgatcattta cataacataa
    12061 attatgtgaa tgatcatact acaacaacaa atctttgact tttccaattt cactttttgg
    12121 aataaccagg tgaatcatat cacccagata cattctggtt gagccgttaa ctgtttggct
    12181 cttgccatta tggacttgag ttgtgatgag gacgttgtgt ggtaagttga gttcatgaac
    12241 ttgtttccca gcaattttat cagaaactgg tatttcgata agtgtaactt ctccttcgct
    12301 agatacttct tctggaagca ttttttccag catggcttca tagactggcg tacctttgag
    12361 caaatccatg ataatataag aaacaagagt gacaagacca agtggcatga ggttgcgaat
    12421 atctcctacc atctcagtta cgaggatcat agcggttaag ggagcttttg atatggctcc
    12481 aaaatagcca ctcattccta gaatgacaaa tatagggaat tgctcttgac tgacaagtcc
    12541 aagattgaca cagataacac caactaaggc accaagcaaa gaaccaagag ctaaaatggg
    12601 taggaaaatt cctcctggca gtccacttcc atagctaatc atactccaaa taaagcggat
    12661 caaaaagtaa gctaataaaa cttggaaact aaaattttgt tcagttaaag aaaggacaag
    12721 ctgatttccg ccaccaagga tttgaggtaa gaagattccg actggtatga taaggataaa
    12781 agccaagatg ggataataag ccctatccaa atggattttt tgaccaatca agtcataaac
    12841 tcttccaacg tttaatacag ctttctcata gagaaaacct gaaaatccaa ggaaaattcc
    12901 catgacgaga tatatccaat actggtctag ggtcatggga ggaatgttat ctgacatatc
    12961 caatactggt gtcaaaccga acatgagtag agacacaaag tttgctacga tgctggctgc
    13021 tagagttgag acccagaaaa agcgcgaaaa atggtgatag acttcttcta caacaaagag
    13081 aagtgctgca ataggagcat taaaggctgc ggctaaacct gctgcagctc cactggcaat
    13141 caaggaacgt tcctctactg gactggattt gagccacttg gcaattcctt taccaccaac
    13201 tgctccaagt tgaatgctgg gtccctctcg acccagcatg agtccactgg caatagcaag
    13261 aatacctagc acatattttt tccaaagaat gccccaccag ttgagggaca tgaggccttt
    13321 cagttcggct tcgacttgag gaattcctga gcctttaata tctttttctg accgtgttag
    13381 tttggcactg agccaacaga tgagtatata aaacaaaacc agtacaaaaa gattgcgcac
    13441 taagtaccct tgatcttgat aaactccttg tatcaggtgg aagccctttt caattaagaa
    13501 acgaaaggat ccgacgataa ttccaacgat gaggccgaca atgattcctc gaccaacttg
    13561 ggatagtata gtgctggatg caaaggcgaa ttctttctta gaacggacta tttccgactg
    13621 ttcctccatg gtatttcctt tcaattaact ttctttttta cctaaaacca gtgatttaac
    13681 gggttcaaag ctggttcggt gaattggggt aactcctagt tttgtgaggc cttccagatg
    13741 tttagctgtg ccatatcctg cattagtagc gaaatcatag ccagagaact gctgatcgta
    13801 ttctttcatc aattcatcac gtgttacctt ggctactata gatgctgctg cgatagagag
    13861 ggagttggca tctcctttga taatggaggt ttgtgaaatg ggcaagtcca gtttcatggc
    13921 atcaatcaaa aggtgctctg gttgagggct gagctgggag attgcttctt gcatggctag
    13981 tttggttgct tcatagatgt tgacttggtc gatgacctga ttatctatga taccaattcc
    14041 aatcgacaag gcttggtctt gaacggcttg gaaaatctcc agatgtttct ttttaggaat
    14101 tttcttgctg tcgttgagac ctttaatctt acaattttta ggtaaaataa cggccgcagc
    14161 gactacagga ccagcaagag gaccacgacc aacctcatca atacctgcaa ttaaggtcaa
    14221 tccttgctta taaagttctt tttcataaga aagcatggat tccaagcgca aattttcatc
    14281 taattcagct tgaatggctc ttttacgctt gctgatttcc ttttgaactc ctgagcgatt
    14341 atccttttca agatctaaaa aaatagggct ttctaactcc ttgactgtca caaggagttc
    14401 tttgatttct ttaatcgttg ccatcgaggt cttccaatgt atctaaggta tagttaccga
    14461 gtttgccatc acggacttcc ttcacgaaga gactgtaaaa acggtcatag tcatcacgga
    14521 aaccgagggc gcgggtcata tccataataa tcacaggcgc ttcttcttca attttcattt
    14581 gtttgaagcg ttcagccagc ttttctggat aatgttcttt gaaataattg ataccaaaaa
    14641 tggtaacctc atccatagga agcaactgat ccttgatagc tccagtcaat gccaacttaa
    14701 gtgcaacagt ttcatcctca aacttaggcc agagaatccc cggtgtatcc aagatttcca
    14761 gatctttatt ggttttaagc cattgttgac cttttgtgac ccctggcttg tttccaacaa
    14821 cagcaatctt tttaccagcc aaacggttca tcagagtgga tttaccagcg tttggaatcc
    14881 cgataatcat ggtacgcaag gtttcaatct gaatcccacg ttctttctgg cgagcaatct
    14941 tatcagccat gagcttcttg gccgcatctg ttacaacttt tacagtcact tgctctttgg
    15001 agttgatagc tagcgtctgg attccttgtg attcaaaata ctgacgccat tccttggtca
    15061 ttgctggatc agccaagtcg gccttgttta aaatcaagag ttttggttta tcaccaacaa
    15121 tcttggtcaa cataggattt tgactagata gaggcaagcg tgcatctact aaaatcgtca
    15181 caaaatcaac aaattttaaa ttctcctgca cctgtcgacg agctttagac atgtgaccag
    15241 gaaaccattg aatagtagcc attgagtttt ttcctttcat agcaaggatt tagatcccct
    15301 attttatttt actatagttt gaacatagag agttttcaaa tgaatgatgt ccaaacagtt
    15361 cttgttttat gacatagaaa tctactttat attatatcat gccttcttta ttttgtccga
    15421 tgatagcctt ttaccctatc ttttacccta taccctatcc tataccctat atagaaaaaa
    15481 gccatcaaat gatgactttt cagagggagc aaaaaactgt cctctttatg ttttaaacat
    15541 ttaacccaaa tcattcatac ctctctcaac tagatgtaac ttacaaaacc cctgacctca
    15601 tgagccactt tcttcctcct catgaggtca gttttacttt ctgctgttcc agtatcgttt
    15661 ttcctcgcta gatttcctca aaagagcaga ctcctccctt ggtgcgtcac acgatttttt
    15721 catctcgact gttctttaat gcatcattaa cgacgctttt cttctaggtg gttcataagg
    15781 aa
//
LOCUS       DAVLHC010000040        15357 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.041, whole genome shotgun sequence.
ACCESSION   DAVLHC010000040 DAVLHC010000000
VERSION     DAVLHC010000040.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 15357)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15357)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15357
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.041"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            333..680
                     /gene="ssrA"
                     /locus_tag="VXE25_001583"
     tmRNA           333..680
                     /gene="ssrA"
                     /locus_tag="VXE25_001583"
                     /product="transfer-messenger RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00023"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00023"
     gene            complement(853..940)
                     /locus_tag="VXE25_001584"
     tRNA            complement(853..940)
                     /locus_tag="VXE25_001584"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(904..906),aa:Ser,seq:gga)
     gene            1103..1843
                     /locus_tag="VXE25_001585"
     CDS             1103..1843
                     /locus_tag="VXE25_001585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000920650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HEV0772020.1"
                     /translation="MLKTERKQLILEELNQHHVVSLEKLVSLLETSESTVRRDLDELE
                     AENKLRRVHGGAELPHSLQEEETIQEKSVKNLQEKKLLAQKAASLIKEKDVIFIDAGT
                     TTAFLIHELVNKNVTVVTNSIHHAAQLVEKQIPTVMVGGNVKTATDASIGGVALNQIN
                     QLHFDRAFIGMNGVDDGYYTTPDMEEGAVKRAILENAKQTYVLVDSSKIGQTCFAKVA
                     PLKRAIVITSQGHELLQVIKEKTEVIEV"
     gene            1840..2751
                     /gene="pfkB"
                     /locus_tag="VXE25_001586"
     CDS             1840..2751
                     /gene="pfkB"
                     /locus_tag="VXE25_001586"
                     /EC_number="2.7.1.56"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015605104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-phosphofructokinase"
                     /protein_id="HEV0772021.1"
                     /translation="MIYTVTLNPSIDYIVRLDQVKVGSVNRMDSDDKFAGGKGINVSR
                     VLKRLNIPNTATGFIGGFTGKFITDTLAEEEIETRFVQVAEDTRINVKIKADQETEIN
                     GTGPTVESVQLEELKAILSSLTAEDTVVFAGSSAKNLGNVIYKDLISLTRQTGAQVVC
                     DFEGQTLIDSLDYQPLLVKPNNHELGAIFGVKLESLDEIEKYARELLAKGAQNVIISM
                     AGDGALLVTSDGAYFAKPIKGTVKNSVGAGDSMVAGFTGEFVKSKDAVEAFKWGVACG
                     TATTFSDDLATAEFIKETYGKVEVEKR"
     gene            2748..4700
                     /locus_tag="VXE25_001587"
     CDS             2748..4700
                     /locus_tag="VXE25_001587"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEV0772022.1"
                     /translation="MKIQDLLRKDVMLLDLQATEKTAVIDEMIKNLTDHGYVTDFETF
                     KEGILAREALTSTGLGDGIAMPHSKNAAVKEATVLFAKSNKGVDYESLDGQATDLFFM
                     IAAPEGANDTHLAALAELSQYLMKDGFADKLRQATSADQVIELFDQASEKTEELVQAP
                     ANDSGDFIVAVTACTTGIAHTYMAQEALQKVAAEMGVGIKVETNGASGVGNQLTAEDI
                     RKAKAIIIAADKAVEMDRFDGKPLINRPVADGIRKTEELINLALSGDTEVYRAANGAK
                     AATASNEKQSLGGALYKHLMSGVSQMLPFVIGGGIMIALAFLIDGALGVPNENLGNLG
                     SYHELASMFMKIGGAAFGLMLPVFAGYVAYSIAEKPGLVAGFVAGAIAKEGFAFGKIP
                     YAAGGEATSTLAGVSSGFLGALVGGFIAGALVLAIKKYVKVPRSLEGAKSILLLPLLG
                     TILTGFVMLAVNIPMAAINTAMNDFLGGLGGGSAVLLGIVLGGMMAVDMGGPVNKAAY
                     VFGTGTLAATVSSGGSVAMAAVMAGGMVPPLAIFVATLLFKDKFTKEERNSGLTNIIM
                     GLSFITEGAIPFGAADPARAIPSFILGSAVAGGLVGLTGIKLMAPHGGIFVIALTSNA
                     LLYLVSVLVGAIVSGVVYGYLRKPQA"
     gene            4864..7089
                     /locus_tag="VXE25_001588"
     CDS             4864..7089
                     /locus_tag="VXE25_001588"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000908822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA translocase FtsK"
                     /protein_id="HEV0772023.1"
                     /translation="MLISLGIAILLIFAAFKLGAAGITLYNLIRLLVGSLAYLAIFGL
                     LIYLFFFKWIRKQEGLLSGFFTIFAGLLLIFEAYLVWKYGLDKSVLKGTMAQVVTDLT
                     GFRTTSFAGGGLIGVALYIPTAFLFSNIGTYFIGSILILVGSLLVSPWSVYDIAEFFS
                     RGFAKWWEGHERRKEERFVKQEEKARQKAEKEARLEQEETEKALLDLPPVDMETGEIL
                     TEEAVQNLPPIPEEKWVEPEIILPQAELKFPEQEDDSDDEDVQVDFSAKEALEYKLPS
                     LQLFAPDKPKDQSKEKKIVRENIKILEATFASFGIKVTVERAEIGPSVTKYEVKPAVG
                     VRVNRISNLSDDLALALAAKDVRIEAPIPGKSLIGIEVPNSDIATVSFRELWEQSQTK
                     AENFLEIPLGKAVNGTARAFDLSKMPHLLVAGSTGSGKSVAVNGIIASILMKARPDQV
                     KFMMVDPKMVELSVYNDIPHLLIPVVTNPRKASKALQKVVDEMENRYELFAKVGVRNI
                     AGFNAKVEEFNSQSEYKQIPLPFIVVIVDELADLMMVASKEVEDAIIRLGQKARAAGI
                     HMILATQRPSVDVISGLIKANVPSRVAFAVSSGTDSRTILDENGAEKLLGRGDMLFKP
                     IDENHPVRLQGSFISDDDVERIVNFIKAQADADYDESFDPGEVSENEGEFSDGDAGGD
                     PLFEEAKSLVIETQKASASMIQRRLSVGFNRATRLMEELEMAGVIGPAEGTKPRKVLQ
                     Q"
     gene            complement(7134..7562)
                     /locus_tag="VXE25_001589"
     CDS             complement(7134..7562)
                     /locus_tag="VXE25_001589"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000073927.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772024.1"
                     /translation="MSNYRRTSKPKTEHIKKGFTVFQKTVATIASILGLITASITIMN
                     ALDNNKNIKKEPTTSQTTTIVKEIQKESPKENTSPTKETNTSQEKTQQEETPKSSVKE
                     EKKEDQKTATQDSTTPATSKPATENEKQPNTPTSENKSNQ"
     gene            7700..8842
                     /locus_tag="VXE25_001590"
     CDS             7700..8842
                     /locus_tag="VXE25_001590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000638948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase"
                     /protein_id="HEV0772025.1"
                     /translation="MIYFDNSATTKPYPEALETYMQVASKILGNPSSLHSLGDQATRI
                     LDASRQQIADLIGKKSDEIFFTSGGTEGDNWVIKGVAFEKAQFGKHIIVSAIEHPAVK
                     ESALWLKSQGFEVDFAPVDNKGFVDVEALEDLIRPDTTLVSIMAVNNEIGSIQPIEAI
                     SEFLADKPTISFHVDAVQALAKIPTEKYLTERVDFATFSGHKFHGIRGVGFIYIKSGK
                     KITPLLTGGGQERDYRSTTENVAGIAATAKALRLSMEKLDIFRSKTGQMKAVIRQALL
                     DYPDIFVFSDEEDFAPHILTFGIKGVRGEVIVHAFEDYDIFISTTSACSSKAGKPAGT
                     LIAMGVDKDKAQSAVRLSLDLENDMSQVEQFLTKLKLIYNQTRKVR"
     gene            8851..10065
                     /gene="thiI"
                     /locus_tag="VXE25_001591"
     CDS             8851..10065
                     /gene="thiI"
                     /locus_tag="VXE25_001591"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001200101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 4-thiouridine(8) synthase ThiI"
                     /protein_id="HEV0772026.1"
                     /translation="MQYSEIMIRYGELSTKGKNRMRFINKLRNNISDVLSIYPQVKVT
                     ADRDRAHAYLNGADYTAVAESLKQVFGIQNFSPVYKVEKSVEVLKSAVQEIMQDIYKE
                     GMTFKISSKRSDHTFELDSRELNQTLGGAVFEAIPNVQAQMKSPDINLQVEIREEAAY
                     LSYETVRGAGGLPVGTSGKGMLMLSGGIDSPVAGYLALKRGVDIEAVHFASPPYTSPG
                     ALKKAQDLTRKLTKFGGNIQFIEVPFTEIQEEIKAKAPEAYLMTLTRRFMMRITDRIR
                     EVRNGLVIINGESLGQVASQTLESMKAINAVTNTPIIRPVVTMDKLEIIDIAQEIDTF
                     DISIQPFEDCCTIFAPDRPKTNPKIKNAEQYEARMDVEGLVERAVAGIMITEITPQAE
                     KDEVDDLIDNLL"
     gene            10200..11024
                     /locus_tag="VXE25_001592"
     CDS             10200..11024
                     /locus_tag="VXE25_001592"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001076703.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="esterase family protein"
                     /protein_id="HEV0772027.1"
                     /translation="MNQSYFYLKMKEHKLKVPYTGKERRVRILLPKDYEKDTDRSYPV
                     VYFHDGQNVFNSKESFIGHSWKIIPAIKRNPDISRMIVVAIDNDGMGRMNEYAAWKFQ
                     ESPIPEQQFGGKGVEYAEFVMEVVKPFIKHKTGWFDGMMTTGCSMGAYHALNFFLQHP
                     DVFTKVIALSGVYDARFFVGDYYNDDAIYQNSPVDYIWNQNDGWFIDRYRQAEIVLCT
                     GLGAWEQDGLPSFYKLKEAFDQKQIPAWFAEWGHDVAHDWEWWRKQMPYFLGNLYL"
     gene            11037..12203
                     /locus_tag="VXE25_001593"
     CDS             11037..12203
                     /locus_tag="VXE25_001593"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001108652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="HEV0772028.1"
                     /translation="MNYLVISPYYPQNFQQFTIELANKGITVLGIGQESYEQLDEPLR
                     NSLTEYFRVDNLENINEVKRAVAFLFYKHGPIDRIESHNEYWLELDATLREQFNVFGA
                     KPEDLKKTKYKSEMKKLFKKAGVPVVPGAVIKTEADVDQAVKEIGLPMIAKPDNGVGA
                     AATFKLETEDDINHFKQEWDHSTLYFFEKFVTSSEICTFDGLVDKDGKIVFSTTFDYA
                     YTPLDLMIYKMDNSYYVLKDMDPKLRKYGEAIVKEFGMKERFFHIEFFREGDDYITIE
                     YNNRPAGGFTIDVYNFAHSLDLYRGYAAIVAGEEFPASDFETQYCLATSRRANAHYVY
                     SEEDLLAKYSQQFKVKKVMPAAFAELQGDYLYMLTTPSRQEMDQMIADFGQRQE"
     gene            12711..14204
                     /locus_tag="VXE25_001594"
     CDS             12711..14204
                     /locus_tag="VXE25_001594"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000627753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent DNA methyltransferase"
                     /protein_id="HEV0772029.1"
                     /translation="MITGELKNKIDQLWEILWTEGNANPLTNIEQLTYLLFMKDLDSV
                     ELGRESDAEFLGIPYEGVFPKDKPEYRWSTFKNIGDAQEVYRLMTQEIFPFIKNLKGD
                     TDDTAFSRYMREAIFQINKPATLQKAISILDVFPTRGLDVDFDNDKQSITDIGDIYEY
                     LLSKLSTAGKNGQFRTPRHIIDMMVELMQPTIKDIISDPAMGSAGFLVSASRYLKRKK
                     DEWETNTDNINHFHNQMFHGNDTDTTMLRLGAMNMMLHGVENPQISYLDSLSQDNEEA
                     DKYTLVLANPPFKGSLDYNSTSNDLLATVKTKKTELLFLSLFLRTLKPGGRAAVIVPD
                     GVLFGSSKAHKGIRQEIVENHKLDAVISMPSGVFKPYAGVSTAILIFTKTGNGGTDKV
                     WFYDMKADGLSLDDKRQPISDNDIPDIIERFHHLEKEAERQRTDQSFFVPVAEIKEND
                     YDLSINKYKEIEYEKVEYEPTEVILKKINDLEKEIQAGLAELEKLLK"
     gene            14217..14759
                     /locus_tag="VXE25_001595"
     CDS             14217..14759
                     /locus_tag="VXE25_001595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001814217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HEV0772030.1"
                     /translation="MKKVKLGEVLSLKKGKKATVLAEQTTLSQRYIQIDDLRNNNNLK
                     FTESLNMTEALPDDILIAWDGANAGTVGYGLSGAVGSTITVLKKNERYKEKIISDYLG
                     VFLESKSQYLREHSTGATIPHLNKNILLDLQLELLGIEEQENIICILNTIKRLITKRK
                     LQLDELNLLVKSRYSEEVVA"
     gene            14756..>15357
                     /locus_tag="VXE25_001596"
     CDS             14756..>15357
                     /locus_tag="VXE25_001596"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000756118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HEV0772031.1"
                     /translation="MKKVKLGEVATFINGYAFKPQDWSSEGREIIRIQNLTKTSTEIN
                     YYSGTIDKKYIVEAGDILISWSGTLGVFQWCGRSAVLNQHIFKVVFDKIDIDKSYFKY
                     VVEKGLQDAVKHTHGSTMKHLTKKYFDNIIVPYTNLGEQQRIASELDLLSKLILRRQE
                     QLEELNLLVKSRFNEMFGENKIFESIDNLFDIIDGDRGKN"
BASE COUNT         4655 a         2798 c         3393 g         4511 t
ORIGIN      
        1 ggtgcaataa gtgaaaagta gtccgaataa tataaggatt gattttatag tttttaaact
       61 caaatgaatt aaaataaaga gagtacgaaa attctcatct gaaagtattt tagaataatt
      121 ctcttcgtga atttcttcaa aacagatagc ttcatcttag gtatgtgtta attggatttc
      181 gtaagctcta tttacaatcg taaagttatg cactgaaaaa gttgtagtta gtcttccagt
      241 ttgctaaatt tctcgaatag tatctttttt aggtatgtga tttctttttg catttttgag
      301 ttagataagg tataatggtt ttattgtctt ttggggtcgt tacggattcg acaggcatta
      361 tgaggcatat tttgcgactc gtgtggcgac gtaaacgctc agttaaatat aactgcaaaa
      421 aataacactt cttacgctct agctgcctaa aaaccagcag gcgtgacccg atttggattg
      481 ctcgtgttca atgacaggtc ttattattag cgagatacga ttaagccttg tctagcggtt
      541 tgataagaga ttgatagact cgcagtttct agacttgagt tatgtgtcga ggggctgtta
      601 aaataataca taacctatgg ttgtagacaa atatgttggc aggtgtttgg acgtgggttc
      661 gactcccacc ggctccatta ttcctttgca ttccttggta aaacgttgtt aaatcaacgt
      721 tttttatttt tatctttggt attcctttgc attcttttgc taaaaaggga gtcacaaaca
      781 gaccctattt taaaaaaagg atagaaaaaa ggatacaaca tttgtcgcat cctaaaaata
      841 atcttttttc gacggaagac atgggattcg aacccacgca cgctattaca cgcctaccgc
      901 gtttccaaca cggcctctta agcctcttga gtaatcttcc aatacttact caaatagtct
      961 accataaagg ctcttatctt gcaataaaaa ttctagaaat aagaaaaaat gatagatttt
     1021 gaaagaaaat gataaaaaat gcttgacttc gaaagaaagt atggtagaat gaatagtgta
     1081 aacgataaca ggaggtgatt cagtgttaaa aacagaacgt aaacaactga ttttagagga
     1141 gttaaatcaa catcatgtag tttctctaga aaaattagtt agtttgctag aaacgtcaga
     1201 atcaacggtt cgaagagact tggatgagtt ggaagcggaa aacaagcttc gtcgtgtgca
     1261 tggtggagca gaactccccc actccttaca ggaagaagaa accattcaag aaaaatctgt
     1321 caaaaacctt caagaaaaga agttgctggc tcagaaagca gcctctctca ttaaagaaaa
     1381 agatgtcatc tttatcgatg ctggaacaac aactgctttt ttgattcatg aattggtcaa
     1441 taagaatgtt acagttgtga ccaactccat tcaccatgcc gctcagttgg ttgaaaagca
     1501 gattccaact gtcatggttg gaggaaacgt caagacggcg acagatgcta gtatcggtgg
     1561 cgttgctctt aaccagatta accaattgca ctttgaccgt gcctttatcg gaatgaatgg
     1621 tgttgacgat ggctattata cgactcctga tatggaggag ggagctgtga aaagagctat
     1681 tttggagaat gccaagcaga cctacgtctt ggtggattcg tcaaaaattg gacaaacttg
     1741 ctttgccaag gtagcaccac tcaaacgcgc tatcgttatc actagtcaag ggcatgagct
     1801 cttgcaggtt attaaggaga aaacggaggt aatagaagta tgatttatac agtcacactc
     1861 aatccatcca ttgactatat cgttcgtttg gaccaagtca aagttggtag tgtaaatcgt
     1921 atggacagtg atgataagtt tgctggtggg aaaggaatca atgtcagccg tgtcttgaaa
     1981 cgtttgaata taccaaatac agcgacggga tttatcggtg gctttactgg taaatttatc
     2041 acagatactt tagcagagga agaaatcgag acacgttttg tccaggtggc agaagatact
     2101 cgtatcaatg ttaaaatcaa agcagaccaa gaaacagaaa tcaacggaac gggtccaact
     2161 gttgaatcgg ttcagctaga agaattgaaa gctattttat ctagtctgac agcagaagat
     2221 acagttgtct ttgcaggttc aagtgctaaa aatctaggca atgttatcta taaggatttg
     2281 atttccttga cgcgccagac tggtgcgcaa gtggtctgtg actttgaagg acagacctta
     2341 attgatagtt tggactacca gcctcttctt gtaaaaccaa acaatcatga acttggagcg
     2401 atttttgggg ttaaactcga aagtttagat gaaattgaga aatacgctcg tgagttactg
     2461 gctaagggtg ctcaaaatgt tattatctct atggctggtg atggtgccct tcttgtcaca
     2521 tctgatggag cttacttcgc taaaccaatc aagggaacag tcaaaaattc agttggagct
     2581 ggtgattcta tggttgctgg attcacaggt gaatttgtca aatcaaaaga cgcagtagaa
     2641 gccttcaaat ggggagtggc ttgcggaacg gcaactacct tctcagatga cttggcaacg
     2701 gcggaattta ttaaagaaac atatggaaaa gttgaggtag aaaaacgatg aaaattcaag
     2761 acctattgag aaaagatgtc atgttgctag atttgcaggc aactgaaaaa acagctgtca
     2821 tcgacgagat gattaaaaat ttgacagacc acggttatgt aacagatttt gaaacattta
     2881 aagaaggaat tttggcgcgt gaagctttga cttctactgg tttgggtgat ggaatcgcaa
     2941 tgcctcacag caaaaacgct gctgtcaaag aagcgacagt tctatttgct aagtcaaata
     3001 agggtgttga ctacgagagc ttggatggac aagcaactga cctcttcttc atgattgcag
     3061 ctccagaagg tgccaatgat actcacttgg cagccttggc agaattgtct caatacttga
     3121 tgaaagacgg ttttgcagac aaacttcgtc aagcaacatc tgcagaccaa gttatcgaac
     3181 tttttgacca agcttcagaa aaaactgagg aacttgttca agcacctgct aatgactctg
     3241 gtgactttat cgtagctgtt acagcttgta caacaggtat tgcccacact tacatggccc
     3301 aagaagccct tcaaaaagta gctgctgaaa tgggggttgg tatcaaggtc gaaaccaacg
     3361 gtgctagcgg tgttggaaat caactaactg cagaagatat ccgtaaggct aaagctatta
     3421 tcattgcagc agacaaggcc gttgaaatgg atcgatttga tggaaaacca ttgatcaatc
     3481 gtccagttgc tgacggtatc cgtaagacag aagagctaat taacttggct ctttcaggag
     3541 atactgaagt ctaccgtgcc gctaatggtg ccaaagctgc aacagcctct aacgaaaaac
     3601 aaagccttgg tggtgccttg tacaaacact tgatgagtgg tgtatctcaa atgttaccat
     3661 tcgttatcgg tggtggtatc atgattgccc ttgccttctt gattgacggt gctttgggtg
     3721 ttccaaatga aaaccttggc aatcttggtt cttaccatga gttagcttct atgttcatga
     3781 aaattggtgg agctgccttt ggtttgatgc ttccagtctt tgcgggttat gttgcctact
     3841 ctattgctga aaaaccgggt ttggtagcag gtttcgtggc tggtgctatt gccaaagaag
     3901 gttttgcctt tggtaaaatt ccttatgccg caggtggtga agcaacttca actcttgcag
     3961 gtgtctcatc tggtttccta ggtgcccttg ttggtggatt tatcgcaggt gccttggttc
     4021 ttgccatcaa gaaatacgtt aaagttcctc gttcactcga aggtgctaaa tcaatccttc
     4081 tattgccact tcttggaaca atcttgacag gatttgttat gctagctgtg aatatcccaa
     4141 tggctgcaat caacactgct atgaatgact tcctaggcgg tcttggagga ggttcagctg
     4201 tccttcttgg tatcgtcctt ggtggaatga tggctgttga catgggtgga ccagttaata
     4261 aagcagctta tgtctttggt acaggtacgc ttgcagcaac tgtttcttca ggtggttctg
     4321 tagccatggc agcagttatg gctggaggaa tggtgccacc acttgcaatc tttgtcgcaa
     4381 ctcttctttt caaagataaa tttactaagg aagaacgtaa ctctggtttg acaaacatca
     4441 tcatgggctt gtcatttatc actgagggag cgattccatt tggtgccgct gacccagctc
     4501 gtgcgattcc aagcttcatc cttggttcag cagtagcagg tggactcgtt ggtcttactg
     4561 gtatcaaact catggcgcca cacggaggaa tcttcgttat cgcccttact tcaaatgctc
     4621 tcctttacct cgtttctgtc ttggtaggag caatcgtaag tggtgtggtt tatggttacc
     4681 tacgcaaacc acaagcataa aaaatagaaa aatgaaaaga ttggaccgtt tggtgcagtc
     4741 tttttctctt cccgaaatgc ctgtgaaata tggtataata gaagaatggc aaacaagaat
     4801 acaagtacaa caagacggag accgtctaaa gcagaactgg aaagaaaaga agcgattcaa
     4861 cgaatgttga tttcgttagg aattgcgatt ttattgattt tcgcagcctt caaattaggg
     4921 gctgcaggta taacccttta taatttaatt cgcttgctag tgggtagcct agcttatctg
     4981 gcgatattcg gcctattaat ctatctcttc tttttcaagt ggatacgaaa acaggaagga
     5041 ctcttatctg gctttttcac catatttgct ggcttactct tgatttttga ggcctacttg
     5101 gtttggaaat atggtttgga caagtccgtt ctaaaaggga ccatggctca ggttgtgaca
     5161 gatctgactg gttttcgaac gactagcttt gctggagggg gcttgatcgg ggtcgctctt
     5221 tatattccaa cagcctttct cttttcaaat atcggaactt actttattgg ttctatcttg
     5281 attttagtgg gttctctcct agtcagccct tggtctgttt acgatattgc tgaatttttc
     5341 agtagaggct ttgccaaatg gtgggaaggg cacgagcgtc gaaaagagga acgctttgtc
     5401 aaacaagaag aaaaagctcg ccaaaaggct gagaaagagg ctagattaga acaagaagag
     5461 actgaaaaag ccttactcga tttgcctcct gttgatatgg aaacgggtga aattctgaca
     5521 gaggaagctg ttcaaaatct tccacctatt ccagaagaaa agtgggtgga accagaaatc
     5581 atcctgcctc aagctgaact taaattccct gaacaggaag atgactcaga tgacgaagat
     5641 gttcaggtcg atttttcagc caaagaagcc cttgaataca aacttccaag cttacaactc
     5701 tttgcaccag ataaaccaaa agatcagtct aaagagaaga aaattgtcag agaaaatatc
     5761 aaaatcttag aagcaacctt tgctagcttt ggtattaagg taacagttga acgggccgaa
     5821 attgggccat cagtgaccaa gtatgaagtc aagccggctg ttggtgtaag ggtcaaccgc
     5881 atttccaatc tatcagatga cctcgctcta gccttggctg ccaaagatgt ccggattgaa
     5941 gcaccaatcc ctgggaaatc cctaatcgga attgaagtgc ccaactccga tattgccact
     6001 gtatctttcc gagaactatg ggaacaatcg caaacgaaag cagaaaattt cttggaaatt
     6061 cctttaggga aggctgttaa tggaaccgca agagcttttg acctttctaa aatgccccac
     6121 ttgctagttg caggttcaac gggttcaggg aagtcagtag cagttaacgg cattattgct
     6181 agcattctca tgaaggcgag accagatcaa gttaaattta tgatggtcga tcccaagatg
     6241 gttgagttat ctgtttacaa tgatattccc cacctcttga ttccagtcgt gaccaatcca
     6301 cgcaaagcca gcaaggctct gcaaaaggtt gtggatgaaa tggaaaaccg ttatgaactc
     6361 tttgccaagg tgggagttcg gaatattgca ggttttaatg ccaaggtaga agagttcaat
     6421 tcccagtctg agtacaagca aattccgcta ccattcattg tcgtgattgt ggatgagttg
     6481 gctgacctca tgatggtggc cagcaaggaa gtggaagatg ctatcatccg tcttgggcag
     6541 aaggcgcgtg ctgcaggtat ccacatgatt cttgcaactc agcgtccatc tgttgatgtc
     6601 atctctggtt tgattaaggc caatgttcca tctcgtgtag catttgcggt ttcatcagga
     6661 acagactccc gtacgatttt ggatgaaaat ggagcagaaa aacttcttgg tcgaggagac
     6721 atgctcttta aaccgattga tgaaaatcat ccagttcgtc tccaaggctc ctttatctcg
     6781 gatgacgatg ttgagcgcat tgtgaacttc atcaaggctc aggcagatgc agactacgat
     6841 gagagttttg atccaggtga ggtttctgaa aatgaaggag aattttcgga tggagatgct
     6901 ggtggtgatc cgctttttga agaagctaag tctttggtta tcgaaacaca gaaagccagt
     6961 gcatccatga ttcaacgtcg tttgtcagtt ggatttaacc gtgcgacccg tctcatggaa
     7021 gagcttgaga tggcaggtgt cattggtcca gctgaaggta ccaaaccaag aaaagtttta
     7081 caacaataaa aaaatagctt ctttccaagt ttggaaggag gctattttag tggttattga
     7141 ttacttttat tttctgaagt tggagtattg ggctgttttt cattttcagt ggcaggttta
     7201 cttgtagcag gtgtagtaga gtcctgagtt gctgttttct gatcttcttt tttctcttcc
     7261 ttgacgctag attttggtgt ttcctcttgc tgtgtttttt cttgactagt gttagtctct
     7321 ttagttggac tggtgttttc cttaggggat tccttttgga tttctttgac aatggttgtc
     7381 gtctggcttg tcgtaggttc ttttttaata tttttgttat tatccaaggc gttcatgatc
     7441 gtgatactcg cggtaatcaa gccaaggata ctagcgattg tagcaacggt tttttgaaag
     7501 actgtaaagc cttttttgat gtgttctgtt tttggttttg aagttctacg atagttagac
     7561 atacattctc tcctttgatt atgatttatt atactctgtt tctttaaaaa aatcttaaaa
     7621 aaagagaaat tgccctttct tgtcgcaagc tccgtttcat gatacaatag aggaagtgat
     7681 tttagaaagc gtgagaaaca tgatttactt tgataattca gcgacgacca agccttatcc
     7741 tgaagccctt gaaacctata tgcaggtcgc ttcaaaaatt ttaggaaacc catctagtct
     7801 ccatagtttg ggagaccaag caacacgaat cttagatgct tctcgccaac agattgcaga
     7861 tttaatcggt aagaaaagcg atgaaatctt ctttacctct ggtggaacag aaggggataa
     7921 ctgggttatc aagggtgtgg cctttgaaaa agctcagttt ggcaagcaca tcattgtttc
     7981 agccattgaa catccagcag tcaaagagtc agccctctgg ttgaaaagtc aaggatttga
     8041 agtggatttt gctccagttg ataacaaagg atttgtggat gttgaggcgc tagaagattt
     8101 gataagacct gatacgaccc tcgtttccat catggctgtg aacaatgaaa tcggctctat
     8161 ccaacctatt gaggctattt cagaattctt ggcagacaag ccaactattt ccttccacgt
     8221 tgatgcggtt caggcgcttg ccaagattcc gactgaaaag tatctgacag aacgagtgga
     8281 tttcgcgact ttctctggtc acaagttcca cggaatccgt ggtgttggtt ttatctatat
     8341 caagtctggc aagaagatta cgcctctttt aacaggtggt ggtcaggaac gtgattaccg
     8401 ttcgacaact gaaaatgtgg caggaattgc agcgaccgct aaggctctcc gtttatctat
     8461 ggaaaagcta gatatcttta ggagcaagac tgggcagatg aaggcagtga ttcgtcaagc
     8521 acttctggac tatccggata tatttgtctt ttcagatgag gaagacttcg cccctcatat
     8581 tctgactttt ggaatcaagg gtgttcgtgg tgaggtcatt gttcacgcct ttgaagacta
     8641 tgatattttc atctcaacga cctcggcttg ttcgtccaag gctgggaaac cagccggaac
     8701 cctgattgct atgggagtgg acaaggataa ggctcagtca gctgtgcgtc ttagtctaga
     8761 ccttgaaaat gatatgagtc aggtcgagca gttcttgacc aagctaaaat taatttacaa
     8821 tcaaactaga aaagtaagat aggagcattc atgcagtatt cagaaattat gattcgctac
     8881 ggtgagctgt caaccaaggg caaaaatcgt atgcgtttca tcaataaact tcgcaataat
     8941 atttcagacg ttttgtctat ctatccccaa gttaaggtaa cagcagatcg cgaccgtgcc
     9001 cacgcttacc tcaatggagc agattacaca gcagtagcag aatcgctcaa acaagtattt
     9061 ggaattcaaa acttttcccc tgtttataag gttgaaaaat ctgtagaagt tctgaagtct
     9121 gctgtccaag agattatgca ggacatctac aaggaaggca tgacctttaa aatctctagc
     9181 aagcgtagcg accacacctt tgaattggac agtcgtgaac tcaaccaaac gcttggaggg
     9241 gctgtattcg aagccattcc aaacgtacaa gctcaaatga aaagtcctga catcaatctt
     9301 caggtggaga tacgtgaaga agcagcctat ctttcttatg aaaccgttcg aggggcaggt
     9361 ggattaccag tgggaacttc tggtaagggc atgctcatgt tgtcaggggg aatcgattcc
     9421 cctgtagctg gctatctagc gcttaaacga ggggtagata tagaggcagt tcactttgcc
     9481 agcccacctt acacgagtcc tggtgctctt aaaaaagccc aagatttgac ccgtaaatta
     9541 accaaatttg ggggaaatat ccagtttatc gaagttcctt ttacagagat tcaagaggaa
     9601 atcaaagcca aagcgccaga agcctacctt atgaccttga cgcgtcgttt tatgatgcgt
     9661 attactgacc gtattcgtga ggtacgaaat ggtttagtta tcatcaatgg ggaaagtcta
     9721 ggtcaagtag ccagccaaac ccttgaaagt atgaaggcta tcaatgctgt taccaacact
     9781 cccatcattc gtcctgtggt taccatggac aagttggaaa tcattgacat cgcccaggaa
     9841 atcgatacct ttgacatttc aatccaaccg tttgaagact gttgtaccat ttttgcacca
     9901 gatcgtccaa aaacaaatcc taaaattaag aatgcggagc agtacgaagc gcgtatggat
     9961 gttgaaggct tggttgagcg agcagtggct ggaatcatga ttactgaaat cacacctcaa
    10021 gccgaaaaag atgaagttga tgacttgatt gacaatctgc tctaattcag aaaatccaaa
    10081 agaatagcga aaatcagtaa aaaaagttag ttttttctct aaaaacaggt aaaaaactaa
    10141 ctttttttat ttttatgata taatgatata aaattttgaa tatagagagt tttctgacaa
    10201 tgaatcaatc ctacttttat ctaaaaatga aagaacacaa actcaaggtt ccttatacag
    10261 gtaaggagcg ccgtgtacgt attcttcttc ctaaagatta tgagaaagat acagaccgtt
    10321 cctatcctgt tgtatacttt catgacgggc aaaatgtttt taatagcaaa gagtctttca
    10381 ttggacattc atggaagatt atcccagcta tcaaacgaaa tccggatatc agtcgcatga
    10441 ttgtcgttgc tattgacaat gatggtatgg ggcggatgaa tgagtatgcg gcttggaagt
    10501 tccaagaatc tcctatccca gagcagcagt ttggtggtaa gggtgtggag tatgctgagt
    10561 ttgtcatgga ggtggtcaag ccttttatca agcacaaaac aggttggttt gatggcatga
    10621 tgacgacagg ttgctctatg ggagcctatc atgcactcaa tttcttcctc cagcatccag
    10681 atgtctttac caaagtgatt gctctcagtg gtgtttacga cgcacgtttc tttgtcggtg
    10741 attactacaa cgatgatgct atttaccaaa actcgccagt agattatatt tggaaccaaa
    10801 acgatggctg gtttattgac cgttaccgtc aggcagagat tgtgctgtgt acggggcttg
    10861 gagcctggga acaagatggt ttaccatcct tttacaagct caaagaagcc tttgaccaga
    10921 aacaaattcc agcctggttt gctgaatggg gacatgatgt cgcccacgac tgggaatggt
    10981 ggcgtaaaca aatgccttat ttcctcggta atctctattt ataaaaggag ttacctatga
    11041 attaccttgt tatttctccc tactatccac aaaactttca acagtttacc atcgaactag
    11101 ctaataaagg catcacagtc ttgggaattg gtcaagagtc ttacgagcaa ttggatgagc
    11161 ccttgcgcaa tagcttgacc gagtattttc gtgttgataa tcttgagaac ataaatgaag
    11221 tcaaacgtgc agttgctttt ctcttttata aacatggtcc aattgaccgc atcgagtctc
    11281 acaatgaata ctggcttgag ctagacgcaa cactcagaga acaattcaat gtttttggtg
    11341 ccaaaccaga ggatctcaaa aagacgaaat ataagtctga aatgaagaaa cttttcaaaa
    11401 aagcaggtgt tcctgtggta cctggagctg ttatcaagac ggaagcagat gttgatcaag
    11461 cagtgaaaga aatcggtctt ccaatgattg ccaaacctga taatggagtg ggagcagccg
    11521 caacctttaa acttgagaca gaagacgata tcaatcactt caagcaagaa tgggaccatt
    11581 caacccttta tttctttgaa aaatttgtca cttccagcga aatctgtacc tttgacgggc
    11641 tcgtggacaa ggatggaaag attgtcttct caacaacctt tgactacgcc tatacaccgc
    11701 ttgacctcat gatttataag atggacaatt cttattatgt gctcaaggat atggatccta
    11761 aactgcgcaa gtatggggaa gcaattgtca aagaatttgg tatgaaagaa cggtttttcc
    11821 atattgagtt cttccgtgag ggggacgatt atattaccat cgagtacaat aaccgccctg
    11881 caggtggttt taccattgat gtttataact ttgctcattc cttggacctt tatcgtggct
    11941 atgcagctat tgtcgcagga gaggagttcc cggcgtcaga ctttgaaact cagtattgtt
    12001 tggctacttc tcgccgtgca aatgctcact atgtttattc agaagaggat ttgcttgcca
    12061 aatatagcca gcagttcaag gttaaaaaag tcatgccagc tgccttcgcg gaacttcaag
    12121 gagattacct gtatatgctg acaactccga gtcgacaaga aatggatcag atgattgctg
    12181 atttcggaca acgtcaagaa taagaactat cggattaagg aaattcactc ccttaatcct
    12241 tttgttttgt ctggtaaaaa ataagagcat cctaacaagg tagctatcat aaaacttgtt
    12301 cgataactat ttgaagcagg attaggtggc tagaaattga attttaacat ttcaatttag
    12361 tcatagtatt gtgttttcgt atccttaaat cagctaaaag gatccatgac gacacctata
    12421 cgatatagtt ttcaagatac caaacaagtc tattaatatt caatgaaaat caaagagcaa
    12481 actaggaagc tagccgcagg tttctcaaaa cactgttttg aggttgtgga tagaactgac
    12541 agagtcagta tcatatacct acggcaaggt gaagctgacg tggtttgaag agattttcga
    12601 agagtataaa atattcaggt gacgcataga tatagttaat tgaagctttg tttgaaatct
    12661 gataaaataa tgatattact aagttttaaa aactaaagaa aagggaagat atgattacag
    12721 gcgaattaaa aaataaaatc gatcagctgt gggaaattct ttggacagaa ggaaacgcaa
    12781 atcctttaac aaatattgaa cagttgactt atctcttatt tatgaaagat ttggatagtg
    12841 tcgagcttgg acgtgaaagt gatgctgaat ttctagggat tccttatgag ggagtttttc
    12901 caaaagataa acctgaatac cgttggtcaa cttttaaaaa tataggagat gctcaggaag
    12961 tttatcgttt aatgactcag gagatttttc cgtttattaa aaatctcaag ggggatacag
    13021 atgatacagc cttttcacga tatatgcgag aagctatttt tcaaataaat aaacctgcta
    13081 cgcttcaaaa ggcaatttct atcttagatg tttttccaac taggggatta gatgtagatt
    13141 ttgataatga caaacaaagt attactgata tcggagatat ctatgaatat ctgttatcaa
    13201 aattgtcgac cgcaggtaaa aatggacagt tccgtacacc tcgtcacatc atcgatatga
    13261 tggttgagtt gatgcaaccg actatcaaag atatcatctc agatcccgct atgggttctg
    13321 ctggcttctt agtatctgct agccgttact taaagcgtaa gaaagatgaa tgggaaacca
    13381 atacagataa tatcaatcat tttcataatc agatgtttca tggaaatgat acggatacga
    13441 ctatgttgag acttggggcg atgaacatga tgctacatgg agtagaaaat ccacaaatca
    13501 gttaccttga ctcgctgtct caagataatg aagaagccga taaatatact ttggttttag
    13561 caaatcctcc ttttaagggc tcacttgact acaattcaac ctctaatgac cttcttgcaa
    13621 ccgtaaaaac caaaaaaaca gaattactct ttctttctct tttcttgcga actttaaaac
    13681 caggtggacg agcagcagtt atcgtacctg atggtgtcct ttttggttcg tctaaagctc
    13741 ataaaggaat tcgtcaggaa attgtagaga atcataagct tgatgctgta atctcaatgc
    13801 ctagtggtgt gttcaagcct tatgctggag tttcaactgc cattctcatc tttacaaaaa
    13861 ctggtaatgg tggtactgac aaagtctggt tttacgatat gaaagcggat ggtttaagtt
    13921 tggatgataa gcgacaaccg attagcgaca atgatattcc agatattatc gaacgctttc
    13981 atcatcttga aaaagaagca gaacgtcaga gaacggatca atctttcttt gttccagttg
    14041 ctgagataaa ggaaaatgat tatgatttgt ctatcaataa atataaagag attgagtatg
    14101 aaaaagttga gtatgaacca acagaggtca tcttaaagaa aatcaatgat ttagaaaaag
    14161 aaattcaagc tggcttggct gaattagaaa aattactcaa gtagagaggt ggctgtatga
    14221 aaaaagtgaa gttgggggaa gtcttatctc taaaaaaagg caagaaagcc actgtacttg
    14281 ctgaacaaac aactctaagc caacgttata ttcaaataga tgatttaaga aataataata
    14341 atttaaaatt cactgaaagt ttaaatatga ctgaagcact cccagatgat attctgatag
    14401 catgggatgg agctaatgca ggaacagttg gttatggatt atcgggagct gttggtagta
    14461 caattacggt cttaaaaaag aatgagcgat acaaagaaaa aattatatca gattacttgg
    14521 gagtcttttt ggaaagtaaa tcgcagtatt tacgagaaca ttcaacaggt gcaacaattc
    14581 ctcatttaaa caagaatata ttacttgatt tacaattaga attgctaggt atcgaagaac
    14641 aagagaacat tatctgtatt cttaatacga ttaaaaggct tattactaaa agaaaattgc
    14701 agttagatga actaaacttg ctcgtcaaat cccgatattc cgaggaggtg gttgcatgaa
    14761 gaaagtgaaa ttaggggaag tggctacttt tatcaatggc tatgctttta aacctcaaga
    14821 ttggtcatct gaagggagag agattatcag aatacagaat ctgactaaaa cttcaacaga
    14881 gataaattat tattcgggta cgattgataa aaaatacatt gttgaagctg gtgatatcct
    14941 tatttcgtgg tcgggtacat taggggtttt tcagtggtgt ggaagatccg cagtattaaa
    15001 tcagcacatt tttaaagtgg tttttgataa gatagatata gataaatcgt attttaaata
    15061 tgttgttgaa aaaggtttac aagatgctgt aaaacatact catggttcca caatgaaaca
    15121 tttaactaaa aaatattttg ataatattat agttccatat acaaatttgg gagagcaaca
    15181 aagaattgca agtgagctgg atttgttaag caagctgatt ttaaggagac aagaacaact
    15241 tgaagagctt aatctacttg taaaatcccg atttaacgag atgtttgggg aaaataaaat
    15301 atttgaaagc attgataact tatttgatat tatagatggt gataggggca aaaatta
//
LOCUS       DAVLHC010000041        15306 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.042, whole genome shotgun sequence.
ACCESSION   DAVLHC010000041 DAVLHC010000000
VERSION     DAVLHC010000041.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 15306)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15306)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15306
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.042"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..344
                     /locus_tag="VXE25_001597"
     CDS             <1..344
                     /locus_tag="VXE25_001597"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014632353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="ISL3 family transposase"
                     /protein_id="HEV0772032.1"
                     /translation="SEDLKHHYQLYQLLLFHFQNKEPEKFFGLIEDNLKQVHPIFQTV
                     FKTFLKDKEKIVNALQLHYSNAKLEATNNLIKLIKRNAFGFRNFENFKKRIFIALNIK
                     KERTKFVLSRA"
     gene            complement(443..2065)
                     /gene="groL"
                     /locus_tag="VXE25_001598"
     CDS             complement(443..2065)
                     /gene="groL"
                     /locus_tag="VXE25_001598"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018166362.1"
                     /note="60 kDa chaperone family; promotes refolding of
                     misfolded polypeptides especially under stressful
                     conditions; forms two stacked rings of heptamers to form a
                     barrel-shaped 14mer; ends can be capped by GroES;
                     misfolded proteins enter the barrel where they are
                     refolded when GroES binds; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chaperonin GroEL"
                     /protein_id="HEV0772033.1"
                     /translation="MSKEIKFSSDARSAMVRGVDILADTVKVTLGPKGRNVVLEKSFG
                     SPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVREG
                     IKNVTAGANPIGIRRGIETAVAAAVEALKNNAIPVANKEAIAQVAAVSSRSEKVGEYI
                     SEAMEKVGKDGVITIEESRGMETELEVVEGMQFDRGYLSQYMVTDSEKMVADLENPYI
                     LITDKKISNIQEILPLLESILQSNRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKA
                     PGFGDRRKAMLEDIAILTGGTVITEDLGLELKDATIEALGQAARVTVDKDSTVIVEGA
                     GNPEAISHRVAVIKSQIETTTSEFDREKLQERLAKLSGGVAVIKVGAATETELKEMKL
                     RIEDALNATRAAVEEGIVAGGGTALANVIPAVATLELTGDEATGRNIVLRALEEPVRQ
                     IAHNAGFEGSIVIDRLKNAELGIGFNAATGEWVNMIDQGIIDPVKVSRSALQNAASVA
                     SLILTTEAVVANKPEPVAPAPAMDPSMMGGMM"
     gene            complement(2081..2365)
                     /gene="groES"
                     /locus_tag="VXE25_001599"
     CDS             complement(2081..2365)
                     /gene="groES"
                     /locus_tag="VXE25_001599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="co-chaperone GroES"
                     /protein_id="HEV0772034.1"
                     /translation="MLKPLGDRLVLKVEEKEQTVGGFVLAGSAQEKTKTAQVVATGQG
                     VRTLNGDLVAPSVKTGDRVLVEAHAGLDVKDGDEKYIIVGEANILAIIEE"
     gene            complement(2521..2916)
                     /locus_tag="VXE25_001600"
     CDS             complement(2521..2916)
                     /locus_tag="VXE25_001600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000282444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="HEV0772035.1"
                     /translation="MYNKVILIGRLTSTPELHKTNNDKSVARATIAVNRRYKDQNGER
                     EVDFVNMVLWGRLAETLASYATKGSLISVDGELRTRRFEKNGQMNYVTEVLVTGFQLL
                     ESRAQRAMRENNAGQDLADLVLEEEELPF"
     gene            complement(2994..3755)
                     /locus_tag="VXE25_001601"
     CDS             complement(2994..3755)
                     /locus_tag="VXE25_001601"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="HEV0772036.1"
                     /translation="MAKNVVITGATSGIGEAIARAYLEQGEDVVLTGRRIDRLEILKS
                     EFAVSFPNQTVWTFPLDVTDMVMVKTVCSDILETIGRIDILVNNAGLALDLAPYQDYE
                     ELDMLTMLDTNVKGLMAVTRCFLPAMIKVNQGHIINMGSTAGIYAYAGAAVYSATKAA
                     VKTFSDGLRIDTIATDIKVTTIQPGIVETDFSTVRFHGDKERAASVYQGIEALQAQDI
                     ADTVVYVTSQPRRVQITDMTIMANQQATGFMVHKK"
     gene            complement(3797..4423)
                     /locus_tag="VXE25_001602"
     CDS             complement(3797..4423)
                     /locus_tag="VXE25_001602"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4479 and tRNA-binding domain-containing
                     protein"
                     /protein_id="HEV0772037.1"
                     /translation="MIFTYNKEHVGDVLMVIVKNSGDAKLDVERKGKVARVFLKDNGE
                     TVAWNIFEVSSLFETAERGQVFLTDEQVARLNQELQAEGFTEEIVNDKEPKFVVGEIV
                     EMVAHPDSDHLNICQVAVASDKTVQIVAGAPNARVGLKTIVALPGAMMPKGNLIFPGE
                     LRGEKSFGMMCSPRELHLPNAPQKRGVLELSEDQVVGTPFDSAKHWTA"
     gene            complement(4439..4756)
                     /locus_tag="VXE25_001603"
     CDS             complement(4439..4756)
                     /locus_tag="VXE25_001603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000615765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin family protein"
                     /protein_id="HEV0772038.1"
                     /translation="MIQPASLEELASLVEKAGKKVFLFVADWCGDCRYIYPALPEIEE
                     TNPEFTFIRMDRDQYMDLAKLWDVYGIPSLVVLEKDKEIGRFVNRDRKSKQQINDFLA
                     GLK"
     gene            complement(4753..5052)
                     /locus_tag="VXE25_001604"
     CDS             complement(4753..5052)
                     /locus_tag="VXE25_001604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001013971.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4651 domain-containing protein"
                     /protein_id="HEV0772039.1"
                     /translation="MNGMKAKKMWMAGLALLGIGSLALATKKVADDRKLMKTQEELTE
                     IVRDHFSDMGEIATLYVQVYESSLESLVGGVIFEDGRHYTFVYENEDLVYEEEVL"
     gene            complement(5337..5528)
                     /locus_tag="VXE25_001605"
     CDS             complement(5337..5528)
                     /locus_tag="VXE25_001605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000291825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein"
                     /protein_id="HEV0772040.1"
                     /translation="MYYSVDDVVSNAFKKRMILDSFFAFNCSGTMKVSTWVYDKGEWY
                     YVSSSGSMIANDWVKDNGK"
     gene            complement(5689..6363)
                     /locus_tag="VXE25_001606"
     CDS             complement(5689..6363)
                     /locus_tag="VXE25_001606"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725744.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772041.1"
                     /translation="MKKKAFGIVLLVLAAWILLQGNFGIPSLDGKIWPLLGIVFFAYK
                     SIESILRRHLTSAVFTGLLALIIANYAYDLLPVTNHSLIWASILVVLGVGYLTHSSKF
                     WNEKKWWYNGKKTVVTDKEVAFGSGTFYKQDQDLVDDQVEVAFGDAKIYYDNAEMLGD
                     FATLNIEVAFGNATVYVPQHWRVDLKVETSFGAAKADAPVAPTSKTLIIRGDVAFGKL
                     ELVYVK"
     gene            complement(6369..6815)
                     /locus_tag="VXE25_001607"
     CDS             complement(6369..6815)
                     /locus_tag="VXE25_001607"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000776610.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEV0772042.1"
                     /translation="MKLRIEIDGNLEETEIVIKTPTLTDEIADLQRLLQESKAPRLTF
                     YKGTGEYYLDLSEILFFETEGSKIYAHNQKEAYEVRLKLYELESILPRYFNRVSKSTI
                     ANIRQIYSVDKSFSGTGTISFYQTHKEVHVSRHYQSLLKENLRNMR"
     gene            complement(6929..7432)
                     /locus_tag="VXE25_001608"
     CDS             complement(6929..7432)
                     /locus_tag="VXE25_001608"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000800945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatase PAP2 family protein"
                     /protein_id="HEV0772043.1"
                     /translation="MKNYQEWYRNISSRLTSRPILLFLLRSFNRLMTVAMPLVYLILL
                     VTTYLQLGLGQQVGVYVLIPASGFVALSLFRKKINHPRPYETWDICPLLDKDSSGRSM
                     PSRHVFSATIISMACLHASLPIGLVCLIFSALLGLVRVLGGVHYPKDVLVGYACGLVW
                     GFLFFLF"
     gene            complement(7429..7791)
                     /locus_tag="VXE25_001609"
     CDS             complement(7429..7791)
                     /locus_tag="VXE25_001609"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2200 domain-containing protein"
                     /protein_id="HEV0772044.1"
                     /translation="MSQKLYNMKFAAVYLALIAKVERKGGKAESVHQVTSWLTGYEVS
                     DVLACLDRDVTYGDFFRQAPYYVPERIAITGKICGVRIEEIDDPLMQEIRRLDKLVDW
                     LAKGKTSQQVLEKYEKHK"
     gene            complement(7857..9722)
                     /locus_tag="VXE25_001610"
                     /pseudo
     CDS             complement(7857..9722)
                     /locus_tag="VXE25_001610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001850459.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein/permease"
     gene            complement(9732..10202)
                     /locus_tag="VXE25_001611"
     CDS             complement(9732..10202)
                     /locus_tag="VXE25_001611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000360543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HEV0772045.1"
                     /translation="MGKPMLVFKRFGHQIHLMVQKEAKRCGIEFMGGPQGQVVRFLDN
                     REKNQDLVLIKDIEQELNITKSVASNLVKRIVQNGLVELEASPVDKRAKFVRLTDKAR
                     SQMQQVKAFFERIDKQLMEDIDEDELLIFEKVLGQLQANIKGIGGENKEISQKN"
     gene            complement(10326..11042)
                     /locus_tag="VXE25_001612"
     CDS             complement(10326..11042)
                     /locus_tag="VXE25_001612"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015604432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YebC/PmpR family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEV0772046.1"
                     /translation="MGRKWANIVAKKTAKDGANSKVYAKFGVEIYVAAKKGDPDPESN
                     SALKFVIDRAKQAQVPKHIIDKAIDKAKGNTDETFTEGRYEGFGPNGSMLIVDTLTSN
                     VNRTAANVRAAFGKNGGNMGASGSVSYLFDNKGVIVFGGEDADAVFEQLLEADVDVDD
                     VEAQEGTITVYTAPTDLHKAIVALRESGIEEFQVTELEMIPQSEVELSGEDLETFEKL
                     YSVLEDDEDVQKIYTNVDGF"
     gene            complement(11923..13338)
                     /gene="ply"
                     /locus_tag="VXE25_001613"
     CDS             complement(11923..13338)
                     /gene="ply"
                     /locus_tag="VXE25_001613"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001284359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cholesterol-dependent cytolysin pneumolysin"
                     /protein_id="HEV0772047.1"
                     /translation="MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFV
                     VIERKKRSLSTNTSDISVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSID
                     LPGLASSDSFLQVEDPSNSSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQ
                     LKVKFGSDFEKTGNSLDIDFNSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTV
                     TVEDLKQRGISAERPLVYISSVAYGRQVYLKLETTSKSDEVEAAFEALMKGVKVAPQT
                     EWKQILDNTEVKAVILGGDPSSGARVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTS
                     FLRDNVVATFQNSTDYVETKVTAYRNGDLLLDHSGAYVAQYYITWDELSYDHQGKEVL
                     TPKAWDRNGQDLTAHFTTSIPLKGNVRNLSVKIRECTGLAWEWWRTVYEKTDLPLVRK
                     RTISIWGTTLYPQVEDKVEND"
     gene            complement(13349..13681)
                     /locus_tag="VXE25_001614"
     CDS             complement(13349..13681)
                     /locus_tag="VXE25_001614"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772048.1"
                     /translation="MYICIDNSMTKNKELVKNQTFKPALLTRRLVKNFMIEEPDLARN
                     PFTRPTLIDLDKVFMLDNTVIPTSYLARRRRNVSEELYEEILDHLVQPRLISLNKSEF
                     MQLNPGTY"
     gene            complement(13752..14360)
                     /locus_tag="VXE25_001615"
     CDS             complement(13752..14360)
                     /locus_tag="VXE25_001615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000083609.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772049.1"
                     /translation="MSQSSYLSPLLWLKKEADKEKMSATQCQIFFFYYQMFELLFARE
                     SDMKDLCLGTKGFYFSQLEKNLLSGVSRFLKNLEGKVTLKANQEVSARKALFLALTTS
                     QSDWQELAPVFDFYQTIGRLENPSLLSSQDRQHLMWIYQSALEKDYIVKVIGDKHFVL
                     KRQDATKLTARQTQTLEILSQSEDLVNPVYVTLGEKGVLLLD"
     gene            complement(14373..14831)
                     /locus_tag="VXE25_001616"
     CDS             complement(14373..14831)
                     /locus_tag="VXE25_001616"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000186958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4231 domain-containing protein"
                     /protein_id="HEV0772050.1"
                     /translation="MTPEEMYLTERLDVQIAHFLKKSVQHRRRYKVLKITEIVAGFLI
                     AVFCAIPMPGDRYRLISVALSSLGLLCEGIINLYNAKENWISYQKTAQLLEKEKFLYQ
                     CQTEKYAGKTKAFALFVKTCEGLISEEINQWESIQSKEVAASADAPVKKE"
     gene            14956..15306
                     /locus_tag="VXE25_001617"
                     /pseudo
     CDS             14956..15306
                     /locus_tag="VXE25_001617"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; incomplete; missing C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
BASE COUNT         4478 a         3547 c         2763 g         4518 t
ORIGIN      
        1 attcggaaga cttgaaacac cactatcagc tctatcagct cttgcttttt cacttccaga
       61 acaaggaacc agagaaattt ttcggactta ttgaggacaa tcttaagcag gttcatccta
      121 tttttcagac tgtctttaaa accttcctca aagataaaga aaagattgtc aacgcccttc
      181 aactacacta ttctaatgcc aaactggaag cgaccaataa tctcatcaaa cttatcaagc
      241 gcaatgcctt tggttttcgg aactttgaaa acttcaaaaa acggattttt atcgccctga
      301 atatcaaaaa agaaaggacg aaatttgtcc tttctcgagc ttagctgact tcaacccact
      361 acagttgaca aagagcctat aaaaagaagg gttagtcatt ccctcctttt gtgtttttta
      421 taagttgttt tctatagaaa gcttacatca tcccgcccat catacttgga tccattgctg
      481 gagctggggc tactggttct ggtttattgg ctacgactgc ttctgttgtc aaaatcaagc
      541 tggctacaga tgctgcattt tgtagggctg aacgactcac tttaactgga tcaatgatac
      601 cttgatcaat catgttaacc cactcgccag ttgctgcgtt aaatcctata ccaagctcag
      661 catttttcaa acgatcgata acgatagatc cttcaaatcc tgcattgtga gcaatttgac
      721 gaacgggttc ttccaaagca cggagaacaa tattacgtcc tgttgcttca tctcctgtca
      781 attccaaggt agcaacagct ggaatcacat tggcaagagc tgttccaccg cctgcaacaa
      841 taccttcttc aacagctgca cgagtagcgt tgagggcatc ttcaatgcgg agtttcattt
      901 ctttcaactc agtttcagtt gcggctccga ccttaataac cgctacacca cctgacaatt
      961 tggccaagcg ttcttgcaat ttttcacggt caaattcaga agttgtagtt tcgatttgag
     1021 acttgataac cgcaacacgg tgagaaatcg cttcaggatt tcctgcacct tctacaataa
     1081 ccgtgctatc tttgtccacg gtcactctcg ctgcttgacc aagagcttca attgtcgcat
     1141 ctttcaactc aagaccaagg tcttctgtga taactgttcc gcctgttaag atggcgatat
     1201 cttcaagcat ggctttgcga cggtcaccaa aaccaggtgc cttgactgct actacgttga
     1261 aggttccacg aatcttgttc aaaacaagag ttggaagagc ctcgccatcc acatcatccg
     1321 caataatcaa gagtggacga ttgctttgga gaatgctttc caaaagtggc aagatctctt
     1381 ggatattgga aattttcttg tctgtaatca aaatgtacgg attttcaagg tcagccacca
     1441 ttttttcgct atctgtcacc atgtactgtg aaaggtaacc acggtcaaac tgcattcctt
     1501 ctacgacttc aagctctgtt tccataccac gtgactcttc gatggtgatg acaccgtctt
     1561 tgccaacttt ttccattgct tcagagatgt actcaccaac tttttcagaa cgagaagata
     1621 cggctgcaac ttgagcgata gcttctttat tggcaacagg gatggcgttg tttttcaaag
     1681 cttcaactgc tgcggcaact gctgtttcaa tcccacgacg aataccgatt ggatttgcac
     1741 ctgctgtgac gtttttgatt ccttcacgga cgatagcttg ggtcaagact gttgcagtcg
     1801 tagtcccgtc acctgcgata tcattggttt tagaagctac ttctgatacc aatttggcac
     1861 ccatattttc aaaatggtct tctaattcaa tttctttggc aatagtcaca ccgtcattgg
     1921 taatcaatgg tgagccaaat gatttttcaa gaacgacatt gcgacctttt ggtcccaagg
     1981 ttactttaac agtatctgca aggatatcga caccacggac catagctgaa cgggcatctg
     2041 atgaaaattt aatttctttt gacatactta ctttctcctt ctattcttca atgattgcca
     2101 agatgttagc ttcgcctacg atgatatact tttcatcgcc atctttgaca tcaagacctg
     2161 cgtgggcttc aactaagaca cggtctccag ttttaacact tggagcaacc aagtcaccgt
     2221 tcaaggtacg aacaccttgt ccagtagcca caacttgggc tgttttggtt ttttcttggg
     2281 ctgaacctgc gagaacaaag cctccaacag tttgttcttt ttcttctact tttaagacca
     2341 aacggtcccc taatggtttc aacatctgat ttcctccata atgagataga tattattagc
     2401 actctttata cctgagtgct aattcatagt tctattgtat cacttagtca gaaataatca
     2461 agaaaaaagt ctgactttct caagataaaa agcctgagac caactcagac tttttaattc
     2521 ttaaaatggc aattcttcct cttccaagac caaatctgcc aaatcttggc ctgcattatt
     2581 ttcacgcata gcacgttggg cacgactttc caagagttgg aatcctgtca caaggacttc
     2641 ggttacataa ttcatctgac catttttctc aaagcgacgg gtacgcaatt ctccatcaac
     2701 ggaaatgaga ctacctttgg ttgcgtagct tgccaaagtt tctgctagtc tgccccatag
     2761 gaccatattg acaaaatcaa cttcacgttc accgttttgg tctttgtaac gacggttgac
     2821 agcgatagtt gctcgcgcta ctgacttgtc attgttggtt ttgtgcaatt ctggtgtaga
     2881 cgttaaacgt ccaatcaaga taactttatt atacatattt tcttcctcct acttatctat
     2941 tcgtaggaaa tcaaaaaaag ttacagaaat ttgtaacttt tcgagaaaat tttttatttt
     3001 ttatgaacca tgaaacctgt cgcctgttga ttggccataa tggtcatatc tgtaatctga
     3061 acacgacgag gttgactagt cacatagact actgtatctg caatatcctg agcttgcaaa
     3121 gcttctattc cttggtaaac ggacgcagct cgttctttat caccatgaaa acgcactgta
     3181 gaaaaatctg tttcgacaat tccaggctga atggttgtca ccttgatatc cgttgcgatg
     3241 gtatcaattc gcagtccatc cgaaaaggtc ttaaccgcag ccttggtagc tgagtaaaca
     3301 gcggcaccag cataggcgta gattcctgcg gttgacccca tattgataat atgaccttga
     3361 ttgactttta tcattgctgg caagaaacag cgagtaaccg ccatcagacc tttaacattg
     3421 gtatccaaca tggtcaacat atccaactcc tcatagtctt gatagggagc caagtcaaga
     3481 gccagtccgg cgttgttgac caagatatca atcctcccta tcgtttctag aatatcagag
     3541 caaacagtct tcaccatgac catatccgtc acatctagtg gaaaagtcca gacggtttga
     3601 tttggaaagc ttactgcaaa ctccgacttg aggatttcta atctgtctat ccgtcgtcct
     3661 gttagaacga catcctcacc ctgctccaga taagcacgcg caatcgcttc accgattcct
     3721 gaggttgctc ccgtaatcac aacatttttt gccatcttat ttccttctag ctggtctatc
     3781 agatattaac aacttcttag gcagtccagt gtttagctga gtcaaatggt gttccgacaa
     3841 cttggtcttc tgataattca agcaccccac gtttttgtgg agcatttggc agatgcaatt
     3901 cacgaggact gcacatcata ccaaaactct tttcaccacg aagttcacct gggaaaatga
     3961 gattcccttt tggcatcata gctccaggaa gcgcgacaat ggttttcaac cccacacgcg
     4021 cattgggagc tcctgcaacg atttgtacag tcttatcact tgcgactgca acttggcaga
     4081 tgttgaggtg gtcactatct ggatgggcta ccatctcaac aatttcaccg acaacaaact
     4141 taggttcctt atcattaaca atttcttctg taaaaccttc cgcctgcaac tcttggttca
     4201 aacgagcgac ttgctcatct gtcaaaaaga cttgaccgcg ctctgcagtt tcaaataaac
     4261 ttgaaacttc gaaaatattc caagccactg tttccccatt atctttgaga aaaacacggg
     4321 ctaccttgcc tttgcgctcc acatccagtt tggcatctcc gctatttttc acgatgacca
     4381 taaggacatc accgacatgt tctttattat atgtaaaaat cattgtttcc tttttctcct
     4441 atttcagtcc tgctaaaaag tcattgattt gttgcttgct tttacggtcg cgattgacaa
     4501 aacgaccgat ttccttgtcc ttttctagaa caacaaggct aggaattccg taaacatccc
     4561 agagtttggc caaatccata tactgatctc ggtccattcg aataaaggtg aactctggat
     4621 tggtctcctc aatctctggt aaggcaggat aaatataacg gcaatcgcca caccagtctg
     4681 ccacaaaaag gaagaccttc ttgcccgctt tttccactaa agatgctaat tcttctaaac
     4741 ttgctggctg tatcataaga cttcctcctc atagactagg tcttcatttt catagacaaa
     4801 ggtataatga cggccatcct caaaaatgac gccaccaacc aagctctcca gactgctttc
     4861 gtaaacttga acatagaggg tcgcaatttc ccccatgtcg gaaaaatggt ctcgcacaat
     4921 ctctgtcaac tcttcctgag tcttcatgag cttacggtca tctgcaactt ttttcgtagc
     4981 aagagcaagg cttccaatac ctagcagagc caagcctgcc atccacattt ttttagcttt
     5041 cataccattc attttaacac aaaaaaggct tcaggacaaa tgaggaagca gcagaaaagc
     5101 aagtaaaaag cctcttcctt taaggaaaag gacttcgtat actaagagca aactaggaag
     5161 ctagccgcag gctgctcaaa acacggtttt gaggttgtag ataaggcgac gctgacgtgg
     5221 tttgaagaga ttttcaaaga gtattattct tattgccagg cacctaagtt gccaacgtag
     5281 taaccatcag gtgtgtaggt attgcgaaac atcttacttg atgaagccag ataatactac
     5341 ttgccattgt ctttgaccca atcattcgca atcatggaac cagaagaact tacataatac
     5401 cattctccct tgtcataaac ccaagtactg actttcatgg ttcctgagca attaaaggca
     5461 aaaaaactgt ccaatatcat tcgtttttta aaagcatttg acactacatc atctacgctg
     5521 tagtacatag atacatcaaa cgtaaaagcc aaaatatcga aaaatataca acttttaaag
     5581 gcagcatttc attttttaaa gtctaacaac catagaactg aaatcagagc aaggcatcaa
     5641 tttcctactc ttagtacgtc tattttgatg gttgaagtga agattttttt atttaacgta
     5701 gacaagctcc aacttcccaa aggccacgtc tccacgaata atcaaggttt tgcttgttgg
     5761 cgctacagga gcgtccgcct tggctgcacc aaaggatgtt tctactttca aatcgacacg
     5821 ccagtgttgt ggaacataga cggttgcatt tccgaaggcc acttcaatat ttaaagttgc
     5881 aaaatcacct agcatctctg cattatcata gtagatttta gcatccccaa aagcgacttc
     5941 cacttggtca tctacgagat cttgatcttg cttatagaag gtcccgctac caaaagcgac
     6001 ttccttatcc gtgacgactg tttttttccc attgtaccac catttttttt cattccagaa
     6061 cttacttgaa tgcgtcagat aaccaacacc aagtaccacc aagatgctag cccaaataag
     6121 agaatgattg gtaactggta acaagtcata agcgtaattt gcaatgatga gcgccagtaa
     6181 acctgtaaaa actgccgaag tgagatgacg tctaaggatg gactcaatgg acttataagc
     6241 aaaaaaaaca atacctagta aaggccatat tttaccatcc aaagaaggaa ttccaaaatt
     6301 cccttgcagc aagatccaag ctgctaaaac caataaaaca ataccaaatg ctttcttttt
     6361 catgtttttt acctcatgtt tcttagattt tcttttagga gggattggta atgccgtgag
     6421 acatgaacct ccttgtgcgt ctgataaaag gaaatggtgc ccgttcctga aaaggacttg
     6481 tccactgagt aaatctgacg gatgtttgcg atcgttgact tggaaactcg attaaaatag
     6541 cgaggcaaga tagactccaa ctcatagagc ttgaggcgaa cctcataagc ttccttctgg
     6601 ttatgagcgt agatcttgct cccttctgtt tcaaagaaga gaatttctga caggtctaga
     6661 taatattcac ctgtcccctt gtaaaaagtc aacctcggag cctttgactc ttgcaagagc
     6721 cgttgcaagt ctgcaatttc atctgtcaaa gtgggggtct tgatgacaat ttcagtctcc
     6781 tctaaattgc cgtcaatctc aattcgtaac ttcatcacat ctcctttctg actctactat
     6841 atcaaagcta aattaggaat acaagggcaa aaaagcaagt ggtcaatttg aagcagtaag
     6901 tggttgtagg actagcttaa cttacatgtc agaataggaa gaaaaggaat ccccacacca
     6961 aaccacaagc atagccaacc aagacatcct tgggataatg aacaccccct aaaaccctca
     7021 ccaaccccag caaagctgaa aagatcaagc atactaagcc aataggtaga ctagcatgca
     7081 gacaggccat ggagatgata gttgccgaaa agacatggcg actgggcatc gaccgtcccg
     7141 aactatcctt atcaagaagg ggacagatat cccaagtttc ataaggtctc gggtgattga
     7201 ttttcttacg aaacagggac aaggccacaa aacctgatgc aggaataagc acataaaccc
     7261 caacttgctg accaagtcct agttgcaggt aagtggtgac tagcaagatc agatagacca
     7321 ggggcatggc gactgtcatc aaacgattga aactgcgtaa taggaataaa agaattggac
     7381 gactagttag tctggagctg atatttcgat accattcttg ataatttttc atttatgctt
     7441 ctcatacttt tctagaactt gttgagatgt tttccccttg gcaagccaat ccactagctt
     7501 gtccaagcga cgtatttcct gcatcagagg atcatcaatt tcctcaatac ggacaccgca
     7561 aatcttccct gtaattgcaa ttcgttcagg gacataatat ggtgcttgtc taaaaaaatc
     7621 tccgtaagta acatccctat ccagacaagc aagaacatca ctcacttcat accctgtcaa
     7681 ccaactggtc acttggtgaa ctgactctgc ctttccaccc tttcgctcaa cttttgcaat
     7741 caaggctaag tagacagcag caaatttcat attgtataat ttctgactca tacttctctc
     7801 tttctatgtg tactagtata aataagaaaa agaaggccgt caagccttct tttgatttat
     7861 tcttctgctt catcttctgt aaattgacta ttgtacaagt cagcgtagaa gccaccttgc
     7921 gccatcagtt cctcatagtt gccttgctcg atgatatttc catctttcat gaccaagatc
     7981 aagtctgcat ttcggatggt tgacaagcgg tgggcaatga caaaggatgt gcgtccttcc
     8041 atcaaacggt ccatggcttt ttggatcaat tcctctgtcc gtgtgtcaac agaagaagtc
     8101 gcctcatcca aaatcaaaag cggtgcatcc ttaagaaggg cacgagcaat agtcaatagt
     8161 tgtttttgtc ctacagacaa ggtcacggtg tcatccaaga tggtatcata gccatctggc
     8221 aaggtcataa taaagtggtg aattcccaca gccttactag cttccatcat tcgttcatca
     8281 ctaatcccta tttgattata gatgagattg tctcgaatag ttccttcaaa gagccaggta
     8341 tcctgcaaga ccattgaaaa ggcatcatgc acttctgaac gcgtcatagc cttggtatcc
     8401 acaccatcaa tgtgaatact tcccttatca atctcataga atttcatcaa aagattgaca
     8461 atggttgtct taccagtccc agtcggccca acaatggcaa ccttttgacc agcatgagct
     8521 gtcgcagaga agtcatagtc ttgaacattg acaccgtcca ccagaatttc tcctgctgac
     8581 acgtcgtaga aacgtggaat cagattgacc agagttgatt taccagaacc tgttgaccca
     8641 ataaaggcca ctgtttgacc agtttctgct ttaaagctaa catgttcaat aactgcctcc
     8701 gaatttgccg catagcggaa ggtcacatcc ttaaactcga cctgaccttt gaagttttca
     8761 tcagtcagct gtacttgaac agggttttgg atagaagaat gcaaatctaa aacttgatta
     8821 atccgcttag cagagaccat agttcgggga agaacgatga agagtgctcc catgagaagg
     8881 aagcccatga caacctacat ggcataagac atgaaaataa tcatgtcact aaagagaggc
     8941 agacgcgcta tcggagcagc gtcgttaatc acataggccc caatccagta aatcgctaca
     9001 ctcaaaccac ttgaaatccc catcatgata ggattcaaaa tagccataag acggttgaca
     9061 aacaaattca aacgggtcaa ttcatcattt actgctgcaa atttttcatt ttgataatcc
     9121 tctgcattgt aggcacgaac gacacgaata cctgttaaac tctcacgagt gatactgttc
     9181 agtttatctg tcaacccctg aatcaaggac tgttttggaa aggctagcgt catcaaaacg
     9241 gtcgtcatca ggacgttgac aatcactacc acaagtacgg cccagagcca gtattctgaa
     9301 tgacctaaaa tcttcccaat agcccagata gccataattg aaccacgcgt taccacttgc
     9361 aagcccatag taatcaacat ttgaacttga gtaatgtcat tggtagtacg cgtcaagagg
     9421 ctaggaattg aaaatttctt aatctctgtc tgcgagtaat ccaaaactcg gttaaaaata
     9481 tcacttctca gcctactagt ataagaagcc gccactcggg atgcaaaaaa tccaactgca
     9541 actacggaca agaaggcaag aaaggacatt cccatcatca tgcttgccgg ctgccacaac
     9601 tcatctaaat tagtttcttg actacctagc aaatccgtaa ttttcgagat ataggtcggc
     9661 acttccaact ctagatagac cgaaaagcaa gtaaagagaa tggctagtaa aatcatcccc
     9721 attcttttct actaattctt ttggctaatt tctttattct ctcctcctat tcccttgata
     9781 tttgcctgta gttgaccgag aactttctca aaaatcagta attcatcttc atcaatgtct
     9841 tccatcaact gcttgtctat gcgttcaaaa aaagccttaa cctgttgcat ctgagaacgt
     9901 gctttgtccg tcagacgaac aaacttagcc cgcttatcaa caggactcgc ctccaattcc
     9961 accaaaccat tttgcactat acgcttaacc agattactag caacagactt ggtaatattg
    10021 agttcctgct cgatatcttt aatcaagacc aagtcttggt ttttctcgcg attatccaaa
    10081 aaacgcacaa cctgaccttg cggcccaccc ataaattcaa tgccgcaacg tttggcttcc
    10141 ttttgcacca tcaggtgaat ttgatgacca aaacgcttaa agactaacat cggtttaccc
    10201 ataatctccc ccttctaaat aaaaatagtt ctctggagaa taattaaatt tctatgagaa
    10261 ctattttctt gattaaaaaa atcccaagtg attttctcac ttaggatcat gttctatagg
    10321 ttaaattaaa acccatctac gttcgtataa atcttttgga cgtcttcgtc gtcttcaaga
    10381 acgctgtaaa gtttttcaaa ggtttcaagg tcttcgcctg acaattccac ttctgactga
    10441 ggaatcattt ccaattcagt cacttggaat tcttcaatac cagactcacg gagggcaacg
    10501 atagccttgt gaaggtcagt tggcgctgtg taaactgtga ttgtaccttc ttgtgcttct
    10561 acgtcatcca catccacatc cgcttcgagc aattgctcaa agactgcgtc cgcatcttca
    10621 cctccaaata caataacacc tttgttgtca aagaggtaag aaacagaacc tgaagcgccc
    10681 atgtttccgc cgtttttacc aaaggctgca cggacattgg ctgctgtacg gttgacgtta
    10741 gaagtcaaag tatccacaat tagcatagag ccatttggcc caaaaccttc gtaacgtcct
    10801 tctgtaaagg tttcgtctgt gtttcctttg gctttatcaa tcgctttatc gataatgtgt
    10861 tttggcactt gggcttgttt agcacggtcg ataacgaatt tcaaagctga gtttgattct
    10921 ggatctggat cacctttttt agctgctaca tagatttcta caccaaattt tgcatatact
    10981 ttagagttag ctccatcttt agccgttttc ttggctacga tattggccca tttacgtccc
    11041 attaggaatc tccttttttc acattttaat ctttcttatt ataacacaag tttttttgat
    11101 tttcactaga ggaaatggat tttattagca aatcaagcta ggatagcact ttacctgcta
    11161 agacggtctt gcctttctat ctttatcaac agacactcat ccacattcaa aaaacaaact
    11221 agaccattat ctgcaaatag aaagtttcag ccaagtttga caaagtcagc tcaaattact
    11281 gtttgaagtt tgtagatata agcgacaaaa acaatcatac tgcacctttt gttgacagtc
    11341 tactccagac atatcatagt tcaagtaaat actttgaaat ccaacagttc ttataggcgc
    11401 tattgtattc taagaaatca atagaagagt ttctaagcaa acctctaata ctcaataaaa
    11461 atcaaagaac aaaccagaaa gctagccgca ggttgctcaa aacactgttt tgaggttgcg
    11521 gatagggctg acctggtttg aagagatttt cgaagagtat aatttacgtg ttcccaagat
    11581 ggagaagtta gactagtaca ctggcacttc taaaccattg ctagcaattg atttgttcat
    11641 atttaatttc attttttcca taaatgggta ttagatataa acagcaaaat atttccgata
    11701 cgtgtcattc ttgaatttcc aatcatctaa aacaagtaaa ggataatcaa tcccctgtat
    11761 atcaaggaat tggctaccct ttttactttt ttacacatcc tgtttgatag actcatttta
    11821 acatcacgag catactccaa tggaaatcgc taggcaagag ataaactttc agatatccgc
    11881 agagagatca tcgcctcttt ttgtcgcaag cattctcttc tcctagtcat tttctacctt
    11941 atcttctacc tgaggataga gagttgttcc ccaaatagaa atcgtccgct tacgcactag
    12001 tggcaaatcg gttttttcat aaaccgtacg ccaccattcc caggcaagcc cggtacactc
    12061 tctaattttg acagagagat tacgaacatt cccttttaaa ggaatactag tggtaaagtg
    12121 agccgtcaaa tcctgcccat ttctgtccca agccttagga gtcaagactt ccttaccttg
    12181 atgatcatag gataattcat cccaagtaat ataatattgg gcaacatagg caccactatg
    12241 atccagcagt aaatctccgt ttctgtaagc tgtaacctta gtctcaacat agtctgtact
    12301 gttttgaaag gtcgcaacta cattgtcacg taaaaaagaa gttgtatagg aaatcggcaa
    12361 gcctggatga tctgctgtaa agcgactgcc ttcttgaatc aagtcctcta ccatatccac
    12421 cttgcctgtt acaactcggg cacccgaact tgggtcgccc cctaaaataa ccgccttcac
    12481 ttctgtattg tccaaaatct gcttccactc tgtctgagga gctaccttga ctcctttcat
    12541 caaagcttca aaagcagcct ctacttcatc actcttactc gtggtttcca acttgagata
    12601 gacttggcgc ccataagcaa cactcgaaat atagaccaaa ggacgctctg cagaaattcc
    12661 tctctgtttt aaatcctcta ccgttacagt atcttgaaac acatctcctg gatttttaac
    12721 agcgtctacg ctgactgtat aataaatctg cttaaaatta acaatctgaa tctgcttttc
    12781 acctgaatgg acagagttaa aatcaatatc aagagaattc cctgtctttt caaagtcaga
    12841 accaaacttg accttgagtt gttccatgct gtgagccgtt attttttcat actgcattct
    12901 agctgggaca ttattgacct gaccataatc ttgatgccac ttagccaaca aatcgtttac
    12961 cgctccgcga acacttgaat tgctggggtc ttccacttgg agaaagctat cgctacttgc
    13021 caaaccaggc aaatcaatac tataagtcat cggagcacga tcaaccgcaa gaagagtggg
    13081 attattctct aacaaggtct catccactac gagaagtgct ccaggataga ggcgactgtc
    13141 gttggtagct gttacagaaa tatcacttgt atttgtcgac aagctccgct tctttctttc
    13201 gataacaaca aactcatcgg gtagctgatt accctctttg atgaaacgat tttcaatact
    13261 ttctccctga tgggtcaaga gtttcttttt atcgtaattc atagctagta taaagtcatt
    13321 tactgcttta tttgccatct tctacctcct aataagttcc tggattgagt tgcataaact
    13381 cagacttgtt cagcgaaatc agccgtggtt ggactaagtg atccaaaatt tcctcgtaca
    13441 attcttctga gacattgcgt cgccgtctgg ctagataaga agtcggaata accgtattat
    13501 ccaacataaa taccttatct aagtcaatca aggttggtct tgtaaaagga ttacgagcta
    13561 gatccggctc ttctatcata aagttcttga ccaaacgtct ggtcaagaga gctggtttga
    13621 aggtctgatt tttaaccaac tctttgtttt tagtcatgct gttgtcaata cagatataca
    13681 tatgattctt cacagccaaa tcgctactaa tagtcggaaa aggcaaataa agagctacaa
    13741 catctcctct cttaatcaag caagagcacc cccttttctc ctaatgtaac atagacagga
    13801 ttgaccaagt cttctgattg actcagaatt tccaaagttt gagtttggcg cgctgtcaat
    13861 ttagtagcat cttgtctctt caatacaaaa tgcttgtcgc caataacctt gacaatataa
    13921 tccttctcca aagctgactg gtaaatccac atcagatgtt gtctgtcctg agaactcaag
    13981 agagaaggat tttcaagcct cccgatagtc tgataaaaat caaaaacagg agctaactcc
    14041 tgccaatctg attggctagt tgtcaaggct agaaaaaggg ctttgcgagc tgatacttct
    14101 tggttagcct tgagagttac tttcccctcc aagtttttta gaaatcggga aactccagaa
    14161 agcaaatttt tctctaactg cgagaaataa aaacctttcg ttcccagaca taagtctttc
    14221 atgtcgcttt ctctagcaaa taagagctca aacatttgat agtaaaagaa aaatatctgg
    14281 cactgggtcg cgctcatctt ttccttatcg gcttcttttt ttaaccagag caagggcgac
    14341 aggtaactgg attgagacat ttcctctacc tcctactctt ttttaactgg agcatctgca
    14401 ctagctgcca cttcttttga ctggatactt tcccactggt taatctcctc tgagataaga
    14461 ccttcgcatg tcttgacaaa tagggcaaaa gccttggtct ttcctgcata tttctccgtt
    14521 tggcattgat agaggaattt ttctttctcc aggagttgcg cagttttttg gtaagaaatc
    14581 caattttcct ttgcattata caaattgata atcccctcac acagcaagcc gagactggat
    14641 aaggcaaccg aaatcaaacg gtagcgatca cctggcatag gaatagcaca aaagacagct
    14701 atgaggaaac ctgccacgat ttctgttatt tttaatacct tatagcgcct acgatgttga
    14761 acgcttttct ttaaaaaatg agctatctgt acgtctaatc gctctgtcag gtacatttct
    14821 tctggcgtca tattcgtaac tcctttcatt tactttgata accatagtat aacatatttg
    14881 aatatcaaag tatagtaaaa actggactat aacttattag acttcctgcg aaacaaaata
    14941 tggtatagta gttctatgaa ttatgaagca agtaaacaac taactgatgc acgatttaag
    15001 cgtcttgtta gtgttcagcg taccactttt aaagagatgt tagctgtatt aaaaacagct
    15061 tatcaaaaaa gtcggacaag ctggtaaaat cttggctgac agtggttatc aagggctcat
    15121 gaagatatat cctcaagcac aaattccacg taaatccagc aaactcaagc cgctaacagt
    15181 tgaagataaa gcctgtaacc atgcgctatc taaggagaga agcaaggttg agaacatctt
    15241 tgtcaaagta aaaacgttta aaatgttttc aacaacctat cgaaatcatc gtaaacgctt
    15301 cggatt
//
LOCUS       DAVLHC010000042        15087 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.043, whole genome shotgun sequence.
ACCESSION   DAVLHC010000042 DAVLHC010000000
VERSION     DAVLHC010000042.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 15087)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15087)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15087
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.043"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..188
                     /locus_tag="VXE25_001618"
     CDS             <1..188
                     /locus_tag="VXE25_001618"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="restriction endonuclease"
                     /protein_id="HEV0772051.1"
                     /translation="KNKELNKEVAFYLTSIIRQALKNTEYKDQISSTVLPDIKIKLPI
                     DSRGTPDWNYMERYRDR"
     gene            154..468
                     /locus_tag="VXE25_001619"
     CDS             154..468
                     /locus_tag="VXE25_001619"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001835032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772052.1"
                     /translation="MGITWKDIEIDKEREGEIDKKSTPIFYGEFKNVRLSKEEYKNLK
                     EKLNSHTDIMINKLSRYMESSGKTYQNHYVTILKWYEEDKDKLRQKGLNKKMNYDVGE
                     SL"
     gene            1152..1313
                     /locus_tag="VXE25_001620"
     CDS             1152..1313
                     /locus_tag="VXE25_001620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005761276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772053.1"
                     /translation="MDNDWNGLADLIANLIAKYAGALDLDNLPDPTPAKNQEMKNSFD
                     MAKTQIETD"
     gene            1405..3045
                     /locus_tag="VXE25_001621"
     CDS             1405..3045
                     /locus_tag="VXE25_001621"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000031864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HEV0772054.1"
                     /translation="MSKEKIKVYLYTRVSTSIQIEGYSLEAQKSRMKAFAIYNDYEIV
                     GEYEDAGKSGKSIEGRIQFNRMMEDIKSGKDGVSFVLVFKLSRFARNAADVLSTLQIM
                     QDYGVNLICVEDDGIDSSKDAGKLMISVLSAVAEIERENIRIQTMEGRIQKAREGKWN
                     GGFAPYGYKLEDGKLFINEEEAVAIRTIFDQYVNTTIGANGISKYLENHGIRKIPRQN
                     GKNPVYNGKIAFGRRTLEKVHGTRNEYKQVEQDEYLISEGIHEAIVSDEVWQAAQVKL
                     KSQAKKYEHVNKGKDTRTHLLSGIVKCPICGVGMFGNKCIKKKKDGTKYKDFYYYGCK
                     HRQMIRGHKCTFSKQIREELLDDAVAEVIVKIVSNPKFASMMQEKINMKVDTSEIEKE
                     IDNYQKELRKSHSTKFKLIEEIDNLDVEDKHYKRRKQDLDDRLYRMYDKIDELESSLI
                     DAKAKKQTIEAEKLTGDNIYKILIYFDKLYKVMNDVERRQLISALISEIQVYEEKQSN
                     GQWLKSITFKLPIIEENLNIGLDNDEQVECVSLLEKRS"
     gene            3313..3879
                     /locus_tag="VXE25_001622"
     CDS             3313..3879
                     /locus_tag="VXE25_001622"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772055.1"
                     /translation="MVILELYQNDYSKDLVAFDSIEDGKAFVAQIPGYTLETEDGFEV
                     EYFNPKNIPDYMEIIFNGNIVPLSKFMFDPEENVNIIWKEISNLSLKNDRVIEGYSKI
                     DAYVVNNHEVKAYVETRETNYRKAKDFLESRGYEIDRSFFGSEDGEAILYRKKGIEVW
                     HFLCHLDPMFVEIEDVEGYVKEEVGEIQ"
     gene            4201..4389
                     /locus_tag="VXE25_001623"
     CDS             4201..4389
                     /locus_tag="VXE25_001623"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000179767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CopG family transcriptional regulator"
                     /protein_id="HEV0772056.1"
                     /translation="MATDKNRIMISLDDKNLEKLENLVEDARDRRGMRLTKSQVIELL
                     LNTVDYFDDIMGAIYSKK"
     gene            4451..5209
                     /locus_tag="VXE25_001624"
     CDS             4451..5209
                     /locus_tag="VXE25_001624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000262024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="HEV0772057.1"
                     /translation="MVVYIRQSKLPSEVSINKYNAQVGAYLQGEEVILYQSFSEIKEL
                     TSEDIVVDYIMETRALLKMMGLNVPVYDYPIELKEFYGRKIYAGILGEIVNIPDNWGK
                     FIKPKAGSKVFTGRVVNETHDLIGIGLPFDYPIWISEVVEFIAEWRCFVLDGRVLDVR
                     PYTGDYHAQFDASVIDEAISCWKDAPIAYGLDIGVTRDGRTLVVEVNDGYALGNYGLS
                     PLKSINFHRARWKEMVKPYFEKNEIFKIQQDVIF"
     gene            5267..6121
                     /locus_tag="VXE25_001625"
     CDS             5267..6121
                     /locus_tag="VXE25_001625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000900021.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ADP-ribosylglycohydrolase family protein"
                     /protein_id="HEV0772058.1"
                     /translation="MLGVIIGDIVGSVYEWNNIKTKDFPLFRKDCFFTDDTVMTCAVT
                     EAIMNGGQKDDFIDAMKKYGSMYPNADYGARFNAWLNSDNREPYNSFGNGSAMRISPC
                     AWIMDCGFYAKTGMWPSSRGLTSLSAEVTHNHPEGVKGAMATADAIFLCRFYFGGYCR
                     EYEQSINDNPTECKRRIKDYIEKEYDYNLSQTLDEIRPNYRFNETCQETVPQAIIAFL
                     ESRDFEDAIRNAISLGGDSDTLAAITCNIAEAAYGIPDWIKDKAYSYLDEPLKDVVRR
                     WENRIKAY"
     gene            6233..7117
                     /locus_tag="VXE25_001626"
     CDS             6233..7117
                     /locus_tag="VXE25_001626"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000710121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol kinase family lipid kinase"
                     /protein_id="HEV0772059.1"
                     /translation="MKKVMVIINPTSGGEKALDYKEKLENKAKEYFEYVETKITEKAL
                     DATHFAEEASREQYDAVVVFGGDGTVNEVISGIDERDYIPKLGIIPGGTGNLITKLLE
                     INQDIDGAIDELDFDLTNKIDIGKANDNYFGYIFSIGSLPEAIHNVEIEDKTKFGILT
                     YAVNTMKSVMTDQVFNIKVETENGNYVGEASHVLVLLTNYFADKKIFEENKDGYANIL
                     ILKDASIFSKLSVIPDLLKGDVVANDNIEYIKARNIKISSDSELESDVDGDKSDNLPV
                     EIKVLAQRVEVFSKPKED"
     gene            7280..7357
                     /locus_tag="VXE25_001627"
     CDS             7280..7357
                     /locus_tag="VXE25_001627"
                     /inference="COORDINATES: protein motif:HMM:NF014902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha amylase N-terminal ig-like
                     domain-containing protein"
                     /protein_id="HEV0772060.1"
                     /translation="MELSAIYHRPESEYAYLYKDKKLHI"
     gene            7421..9019
                     /locus_tag="VXE25_001628"
                     /pseudo
     CDS             7421..9019
                     /locus_tag="VXE25_001628"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000390924.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="alpha amylase N-terminal ig-like
                     domain-containing protein"
     gene            9294..9749
                     /locus_tag="VXE25_001629"
     CDS             9294..9749
                     /locus_tag="VXE25_001629"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000500472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772061.1"
                     /translation="MGAARDFLELINHKGLPLFNPLVGDSHVNNRQEYDNTGSGNLQP
                     EKWNETAKQLYNVIMWLIILWNAKPDTPLFNFKDEVIKYKTYEPFESSIKRVNTTIKN
                     GSKGKTLTEMINGYRADNDIRDEICNFNILKNKIRDMKDQQGNTMESYF"
     gene            10194..10670
                     /locus_tag="VXE25_001630"
     CDS             10194..10670
                     /locus_tag="VXE25_001630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003042293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEV0772062.1"
                     /translation="MIGKNIKSLRKTHDLTQPEFARIVGISRNSLSRYENGTSSVSTE
                     LIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIEIVKERGANLLSRLYRYQDSQGI
                     SIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA"
     gene            10670..11428
                     /locus_tag="VXE25_001631"
     CDS             10670..11428
                     /locus_tag="VXE25_001631"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003042596.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zeta toxin family protein"
                     /protein_id="HEV0772063.1"
                     /translation="MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAG
                     KTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQEYGKDSVEYTKDFAGKMVESLV
                     TELSHLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
                     LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFESIQIYQRDRSCVYDSKENTT
                     SAATVLHDLLFGELNQVEKEMLKSGEERLKDLTN"
     gene            complement(11826..12722)
                     /locus_tag="VXE25_001632"
     CDS             complement(11826..12722)
                     /locus_tag="VXE25_001632"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000384879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HEV0772064.1"
                     /translation="MDYKLISTYLDYCKTHKRLSSHTIRAYKNDLMQFYNSDYDHVES
                     YIEHLTQSNIKTNTLRRKIACMKVFYNYLKYQNIIEENPFNQLRFQFRTEKILPKTIP
                     YDILKNIFIYLEQKVVISKTDYQKQKAERNLLIISLLLSTGIRISELCHIHLKDINLS
                     NKTLHIIGKGKKERILFLGDQTTFNILETYINKTGKESNDFLFPGKHLPKPLSEQSVR
                     LILKRIVEQNSLSKTITPHIFRHSFATMLLDNDVDIRYIQQILGHSSISVTQIYTHVS
                     HSKQKEILSSFNPMSVIHSEIE"
     gene            13052..14821
                     /locus_tag="VXE25_001633"
     CDS             13052..14821
                     /locus_tag="VXE25_001633"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4365 domain-containing protein"
                     /protein_id="HEV0772065.1"
                     /translation="MANNRQIETLGVSYLTTFINRHSLLQTYFGSNDKTPVWDGEIHV
                     LKTSSEKRSEIFGKVPVQIKATRQQKNKLKSFSLDISDLELYSKNGGVVLFVVWLSED
                     GDLRNIYYKSLPPLSIKKLIKKSNLKNKTTSSKKLSVQIHELDEQKLYPMLVDFITNS
                     RKQYSFINVDGISVEDISDDSNLKFYYYGQEKGEIFNYQEENDLFIYYKNPLTGIEVP
                     LENTIKVVETYEETDLIITIGNTIFQNVKRHRFPDGSVQLHFGEGFKMSFDVKKKQFT
                     FNYTRPNMLSKAIKCTQAFQELGKFGYCKLNGNIIELDEQSILDITSRDLETEIEELV
                     QISNFMENMRIQKEVDLTYFDKQSLRNLNILNLGLILKNKVALNYNESKLLHLRIANI
                     HIITLYDFETDNIGTMIDIFTETPWCRRGEGEDSSYISIFEVLEPNDWLKIDNCDFDS
                     VISSYQRLVDNGLKFEDANNTIIKIVIAADKAEDVSRSELLLNWAQCLSDWNLKYSKN
                     CEMAIINDLQIKSRVRKLNSKEMEILSNILVNSNDNYELCFGSSVLLKSKPQADLFWN
                     KLDNETKESYKEFPIYTLYMKLL"
     gene            14850..>15087
                     /locus_tag="VXE25_001634"
     CDS             14850..>15087
                     /locus_tag="VXE25_001634"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000403447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772066.1"
                     /translation="MEIKKVMYYNTVPQFLKPKLNYFARDFLNDYSVQIEDIEAGSNF
                     EVDVEYEGNLEVYFVKFMFRKKGGGMFSGNSENEL"
BASE COUNT         5432 a         2006 c         2973 g         4676 t
ORIGIN      
        1 taaaaaataa agaattgaat aaagaagtag cattctattt aacttcaatt attaggcaag
       61 ctttaaaaaa tactgaatat aaagatcaaa tatctagcac agtattgcca gatatcaaaa
      121 ttaaattacc gatagacagt agaggtactc cagattggaa ttacatggaa agatatagag
      181 atagataaag agagagaggg agagatagat aaaaagtcca cccccatttt ttatggagaa
      241 ttcaaaaatg taaggttaag caaagaagaa tataaaaatc taaaagaaaa attaaactca
      301 cacacagata taatgataaa taaactatcc agatacatgg aaagcagtgg taagacctat
      361 caaaaccact atgtgacaat cttaaaatgg tatgaagaag ataaagacaa actaagacag
      421 aaaggtttaa ataaaaaaat gaattatgat gtaggagaat ctttatagat aaaaagaggt
      481 ggaaaggcac tattaaagac tttaagtcta aaaaggtatc aaagtatgcc agagataaaa
      541 aaatataaat atgacacttt aaaggcgatt agaaaattaa agaaatgcta gaagactttt
      601 agatgacagt taccaagagg gtctaatttt cactgctact tatgcagtgg gaatttgacc
      661 tttttatata agcaaattct atttcaaaat tggttaccaa gaaagacttc ttttcactgt
      721 taagtataag agggtaattt atagaatttt attacattaa gataaatatt ttctgatggt
      781 caaattttaa aaagattaat aactctcgat aaattttgaa ccttaacaat tgaatagacc
      841 aagacaagac gttaattatt tttggagcgt aataacctat ccgtcaagat ctttcggctg
      901 aataattcgg caaaaaaagt tctgctaagt aaaaagaaag tgagcgataa gtaagagttt
      961 gaatataggg agggataccc tatccgctat gaagaaaatg aggataatga tacttctaag
     1021 gttgaagccg gctcatccgg aatagaggcg gaggtgagat tcctatgttg ctaatccaaa
     1081 gcacttgtca atgtcaaaaa acttaattaa acaaataatt attagatata aaactttaga
     1141 ggaggtatat attggacaat gactggaatg gattggctga tttaatagca aatctgattg
     1201 caaaatatgc tggtgcttta gatttagata atctacccga tccaacgcca gcaaaaaatc
     1261 aagagatgaa aaatagtttt gacatggcaa aaacacaaat tgagacggac taataaaagt
     1321 gttataatat acttgaaatg atagtccaaa cttaaattaa aaaaattata tatgatatag
     1381 aaaaattata ttgaggttaa tactatgtca aaagaaaaaa taaaagtata cctctataca
     1441 cgagtatcta cgtcaataca gatagagggg tattcgttag aggcacaaaa atcacgaatg
     1501 aaagcttttg ctatttacaa cgattatgaa attgttggag agtatgaaga tgccgggaag
     1561 tctggcaagt ctattgaagg tagaatacag ttcaatcgaa tgatggaaga tataaaatct
     1621 ggaaaagatg gagtatcttt tgttcttgtg tttaagttat caagatttgc aagaaatgcc
     1681 gctgatgttc tttctacact tcagataatg caggattatg gagttaatct tatctgcgtt
     1741 gaagatgatg gtattgattc atctaaagat gctgggaaac taatgatttc tgttttatca
     1801 gctgtggctg aaatagaaag agaaaacatc cgtattcaaa caatggaagg tcgcattcaa
     1861 aaagcaaggg aaggaaaatg gaatggtggc tttgctccgt atggatataa acttgaagac
     1921 ggcaagctgt ttataaatga ggaagaggca gttgcaataa gaacgatttt cgaccagtat
     1981 gtaaatacta cgataggagc caatgggata tctaaatact tagagaatca tggaattaga
     2041 aaaatcccaa gacagaatgg taagaatcct gtatataatg ggaaaatagc atttggaaga
     2101 agaactttag aaaaagttca tggtacaaga aatgaatata agcaggttga acaagatgaa
     2161 tatctaatat ctgaagggat acatgaagct atagtttccg atgaagtttg gcaagctgct
     2221 caggttaagc taaaatctca agcaaagaaa tatgagcatg tgaataaagg aaaagataca
     2281 cgcacacact tgctttctgg aattgtaaaa tgcccgatat gtggagtggg aatgtttggg
     2341 aacaagtgta tcaagaaaaa gaaagatggc acaaagtata aagattttta ttactatggt
     2401 tgtaaacata ggcagatgat aagaggtcat aagtgtacat tcagtaagca aattagagaa
     2461 gaattgttag atgatgctgt tgcagaggtg attgtcaaga tagtaagtaa tccgaaattt
     2521 gcttctatga tgcaagaaaa aatcaacatg aaggtggata cctctgaaat agaaaaagaa
     2581 atagataatt accaaaagga attgagaaag agtcattcta caaagtttaa gctaattgag
     2641 gaaatagata atttagatgt tgaagataag cattataaga gaaggaaaca ggatttagat
     2701 gatagactat atcgtatgta tgacaaaata gatgaattag aatcatcact aattgatgcg
     2761 aaagcaaaga aacagactat tgaagctgaa aagcttacag gagataacat atataagatt
     2821 ctgatctatt ttgataagct ctataaagtc atgaatgatg tagagcgtag gcagttaatt
     2881 tcagctttga tttctgaaat tcaagtttat gaagaaaaac aatctaacgg acaatggcta
     2941 aaatccatta cttttaagct accaattata gaagaaaatc tcaacatagg tttggacaat
     3001 gatgaacaag ttgaatgtgt aagtttatta gagaaacgta gttaatcctc aaaaggttcc
     3061 ccaaaccttt tgagtcccac tgacgcatca cgctgaggcg gtatcactgc ttgtacgagt
     3121 tgaagcatca gcgaagtaaa agtagatgtt cagccaatgc gacgaggtga gaccgaaggt
     3181 cgataaggtg tgttctgggt ataggactcg taaagtaagt aggaaatatg atgagatgat
     3241 acagagagcc tgaattggtc aggtgacgtg cttatttaca ttagcctgat aatgaaaatg
     3301 gagagattat cgatggttat attggaattg taccaaaatg attattctaa agatttagta
     3361 gcatttgatt ccatagaaga tgggaaagcc tttgtagctc aaatcccggg atacactctg
     3421 gaaacagaag atggttttga agtggagtat tttaatccta aaaacatacc ggattatatg
     3481 gaaattattt ttaacggaaa tattgttcct ttatctaaat ttatgttcga tcctgaggaa
     3541 aatgtaaaca ttatttggaa agagatttca aatttatccc tcaaaaatga tagagtgatc
     3601 gaaggatatt caaaaattga tgcatatgtc gttaacaacc atgaagttaa agcctatgtc
     3661 gaaacaagag aaacgaacta tcgtaaagca aaagacttct tagaaagccg cggatatgaa
     3721 atcgacagaa gctttttcgg aagtgaagac ggtgaagcga ttctttacag aaaaaaaggg
     3781 atcgaagttt ggcatttctt gtgtcactta gacccaatgt ttgtagagat tgaagatgta
     3841 gaaggatatg ttaaagaaga agttggagag attcaatagt caaccaaagt tccttgtgag
     3901 tatatacctt tgctagtaaa agagtcaaaa cgttataacg aaggggggga agaaaaccct
     3961 tgagtgtaag tctttttctt gtttagaggg aaagtattag agtagccgct cataatttat
     4021 actagatttg ataactgatt tgagacagat tttatttcta taaatattgt gaaaattttt
     4081 taataccaaa gatttaaagt tactgtgtta aaaatcctct ccacttttaa actaatgtat
     4141 tataaaagcc agttgacaca agtgtgacac ttgtgataga attaacttga ggtgatgaaa
     4201 atggcaaccg ataaaaatag aataatgatt agcttggatg ataaaaatct agagaaactt
     4261 gaaaatttag tagaagatgc tagagataga aggggaatgc gactaacaaa gtcccaggtt
     4321 attgaattac tcctaaatac cgttgattat ttcgatgata ttatgggggc tatttactca
     4381 aaaaaataag agcaaaattg ctattatttt ttacaaattg gtgtaacact agtgatatag
     4441 gagtgatgaa atggttgttt atattagaca aagtaaatta ccaagtgagg tttcaattaa
     4501 taaatacaat gctcaagtag gtgcctactt acaaggagaa gaagttattt tatatcaatc
     4561 tttttctgaa ataaaagagt taacaagtga agatatagtt gtagattata taatggagac
     4621 tagagcatta ctaaaaatga tgggcttaaa cgttccggtt tatgactatc ctattgagct
     4681 taaagagttt tatggtcgaa agatttatgc tggtatttta ggagagattg tgaatatacc
     4741 tgataattgg ggaaaattta ttaagcctaa agctggttca aaagtcttta ctggaagagt
     4801 tgttaatgaa acccatgatt taataggtat tggtctacct ttcgactatc ctatatggat
     4861 tagtgaggtt gtagaattca tagctgaatg gcgttgtttt gtgttagatg gtcgcgtatt
     4921 agatgttcga ccctatacag gtgattatca tgcacaattt gatgcaagtg taattgatga
     4981 agcgatatca tgttggaaag atgcgccaat agcttatgga ctagatatcg gtgttactcg
     5041 cgatggcaga acacttgttg ttgaagtaaa tgatggttat gcattgggaa attatggcct
     5101 atctccttta aaatcaatca attttcatag agctaggtgg aaagaaatgg taaaacccta
     5161 ttttgaaaaa aatgaaattt ttaaaatcca acaggatgtt attttctaaa ataaatatgg
     5221 tagataacca atataaaaag catcaaaatg aacaaggagg aatctgatgc ttggagtaat
     5281 tattggagat attgtcggtt ctgtttacga atggaacaat atcaaaacaa aggactttcc
     5341 tttatttcgg aaggactgct tttttacaga tgacacggtt atgacctgtg ctgttacaga
     5401 agcaattatg aatggtggac aaaaagacga tttcattgac gcgatgaaga aatatggcag
     5461 catgtatccg aatgctgatt acggtgctcg gtttaatgca tggctaaaca gcgataatcg
     5521 tgagccttat aatagctttg ggaatggatc agctatgcgt atttctccat gtgcttggat
     5581 catggactgt ggtttttatg cgaaaactgg tatgtggcca tcatctagag gacttacgag
     5641 tctttctgca gaggtaactc ataatcatcc agaaggtgtc aaaggcgcta tggctacagc
     5701 tgatgctatc tttctatgtc gtttttactt tggtggttat tgtagagagt acgagcaatc
     5761 aattaacgac aatcctacag agtgtaaaag acgaattaag gattatatag aaaaagaata
     5821 cgattacaat ctatctcaaa ctttagatga aatccgtcct aactatcgtt ttaacgaaac
     5881 atgtcaggaa actgtccctc aagccattat cgcctttctt gaaagtagag acttcgaaga
     5941 tgcgataaga aatgccatct cacttggtgg cgacagtgat actctcgcag caatcacttg
     6001 taacatagca gaggcagctt acggtattcc tgattggatc aaggataagg cctattctta
     6061 cttggatgaa cccttaaagg atgtagttag gcgatgggaa aatagaataa aagcgtatta
     6121 atctccagta cgtcagattt ctcttttctg tattttcatt gtataatagg attacattta
     6181 cttgcatacg acgaaatgta aacatttctg tttaaaatta aggataaaat caatgaaaaa
     6241 agtaatggta attatcaacc ctacttctgg tggcgagaag gctttggatt acaaagaaaa
     6301 gctggagaat aaagcaaaag aatactttga atatgttgaa accaaaatta ccgaaaaagc
     6361 gctggatgca acacattttg ctgaagaagc ttctcgtgag cagtatgatg cagtggttgt
     6421 gtttggtgga gatggaactg tcaatgaagt catttcaggt attgatgaga gagactacat
     6481 tcctaagtta gggattatcc caggcggtac gggtaacctc attacaaaac ttttggaaat
     6541 caatcaagac atcgatggcg caattgacga actggatttt gatttaacca ataagattga
     6601 tatcggtaaa gcaaatgaca actattttgg ttatatcttt agtatcggtt ctctgcctga
     6661 ggcgattcac aatgttgaaa tagaggacaa aacaaaattc ggtattttaa cctatgctgt
     6721 aaataccatg aagtctgtca tgacagatca ggtctttaac attaaggttg agacagaaaa
     6781 tggaaattat gttggtgaag ctagccatgt tttggtcctt ttgacaaatt acttcgctga
     6841 taagaaaatc tttgaagaaa acaaggacgg ctatgccaac attttgattc tgaaagatgc
     6901 ctctatattc tccaaattat ccgtcattcc tgatttatta aaaggggatg ttgtcgcaaa
     6961 tgataatatc gagtatatca aagcgcgtaa tattaaaatc tcttcagata gtgaattgga
     7021 gtcagatgtt gacggagata aatcagataa cctacctgta gaaatcaaag tcctagctca
     7081 gcgagtagaa gtattttcaa aaccgaaaga ggattagtat atagagaaag ccttttttaa
     7141 ggctttttgt atactttaaa agatagttcc tttaacaacg gacattcctt gcaaatagtt
     7201 tacaaaaata gtatactgga tttattgagt ttgaaaacgt ttgcgtaaaa tttgaataaa
     7261 tactttagga gacaaattga tggaattgag tgctatttac cataggcctg agtcggagta
     7321 tgcctatctt tataaggata agaaactcca tatttgaatt cgaactaaga aaggggacat
     7381 tgaaagcatc aacttgcact atggggaccc ttttatcttt atggaggagt tttatcagga
     7441 tacaaaagaa atggtcaaga taacttctgg taccttattt gaccattggc aggttgaagt
     7501 gtcagttgac tttgcacgta tccagtatct ctttgagctc agagatacag aaggtcaaaa
     7561 tattttgtat ggcgataaag ggtgtgtgga aaattctcta gaaaatcttc atgcaattgg
     7621 gaatggattt aagttgcctt atcttcatga gattgatgcc tgcaaggttc ctgactgggt
     7681 ttcaaatacg gtatggtatc agatatttcc tgaaagattt gccaatggca atgctctatt
     7741 aaacccagaa gggactttag actgggattc atctgtcaca cctaagagcg atgatttctt
     7801 tggtggtgat ttacagggga ttattgatcg tatggattac ttgcaagact tgggtattac
     7861 tggactatat ctttgtccca tctttgaatc tacaagcaat cacaagtaca atacgacaga
     7921 ttactttgaa attgaccgtt attttggaga caaggagacc tttcgggaac tggtggatca
     7981 agcgcatcat cgtggcatga aagtcatgat ggatgcggta tttaatcata ttggttcgca
     8041 atctcttcaa tggaaaaatg tcgtcaaaaa tggcgaacag tctgcttata aggattggtt
     8101 ccatattcaa caattcccag tgacaactga aaagctagtt aataagagag acttacccta
     8161 tcatgttttt ggtttcgagg actatatgcc taagctaaat acagccaatc cagaggtcaa
     8221 gaattatctt ttaaaggttg cgacttattg gattgaagag tttaatatcg atgcttggcg
     8281 tttggatgtg gctaatgaga ttgaccatca gttctggaag gattttcgta aggcagtttt
     8341 agctaaaaat cctgatcttt atatcctagg agaagtctgg catacatctc agccttggct
     8401 aaatggagat gagttccatg ccgtcatgaa ttatccttta tctgatagta tcaaggacta
     8461 tttcttacga ggaattaaga agacagacca gttcatcgat gaaatcaatt gagagtctat
     8521 gtattacaag cagcagattt cagaggtcat gtttaatctc ttggattcac atgatacaga
     8581 gcgaatcctg tggacggcca atgaagatgt tcaactggtt aaatcagcct tagcctttct
     8641 cttttaacaa aaaggaacac cgtgcattta ttacggaacc gagctagcct tgactggagg
     8701 accagatcca gattgtcgtc gttgtatgcc ttgggaacgt gtatcaagtg acaatgatat
     8761 gctgaacttt atgaagaggc tgattaagat tcggaaatac gcgtcagtaa tcatttcgca
     8821 tggcaagtat agccttcaag aaatcaaatc tgatctagta gctctggaat ggaaatacga
     8881 aggacggatc ctcaaagcaa tattcaacca atcaacagaa gattatcttt tagagaaaga
     8941 agcagtagca ctagcaagca attgccaaga attggagaat cagcttgtca tctctccaga
     9001 tggatttgtg attttctaaa aactagttga tgaagattat ggtacatttc atatcttata
     9061 tagtataata aggatagtta ctaaacttgt aaaggagaac ttaaatgaat tgtagaggac
     9121 atgaaacaag acaaagaatt gttagagatt ttgaagttta gcctaaagca catattaagc
     9181 tgttagcaaa tcaacaaaaa catagtgatg caggagcaac tattgaagat gaatattatg
     9241 tatttatcgc tgagagtaaa attgatggca agaaggaagt tattcagtgt tgcatgggtg
     9301 cggcaaggga ttttttagaa ctaattaatc acaaagggct acctcttttt aatccgcttg
     9361 taggtgattc tcatgtaaat aatagacaag aatatgacaa tacagggagt ggaaatttac
     9421 aacctgaaaa gtggaatgaa actgcaaagc agctttataa tgttataatg tggttgatta
     9481 ttttatggaa tgctaagccg gatacacctt tatttaattt taaagacgaa gtaattaagt
     9541 ataaaacata tgagcctttt gaaagcagta taaaaagagt aaatactact ataaagaatg
     9601 gtagtaaagg gaaaactctg actgagatga ttaatggcta cagagcggat aacgatatta
     9661 gagatgaaat ttgtaacttt aatattctga aaaataaaat tcgtgatatg aaagaccaac
     9721 aaggaaatac aatggaatct tacttttagt tattgttgaa ttttgggtat tctataaaat
     9781 atcctaattg agatttaaat agtagactat acaatatagt taaaatatca gtaaaaacaa
     9841 cactttattg aggtattgga tacgctttgc taatagccta ataatcacat gtggagtgtt
     9901 gctacaacga aaaaggtgat aatccttgat ttcaagctat tttataagca ttttgtcttt
     9961 gtagataaag gcaattttga caataaaaat cctaaaaggt gaatcgttat agatgtattt
    10021 gtagatatcg tttgcgcatc gaaaaaatta atacaagaat aaatatttat agctctttag
    10081 gtgactttta tagaagtaaa gtttaggata gaaaaacaag aaataacgca ccatttttgg
    10141 tgcgttatgc ttttttatgc tataatggat ttataaaaat aaaggagttt gctatgattg
    10201 gaaagaacat aaaatcctta cgtaaaacac atgacttaac acaacccgaa tttgcaagga
    10261 ttgtaggtat ttcacgaaat agtctgagtc gttatgaaaa tggaacgagt tcagtctcta
    10321 ccgaattaat agacatcatt tgtcagaagt ttaatgtatc ttatgtcgat atcgtaggag
    10381 aagataaaat gctcaatcct gttgaagatt atgaattgac tttgaaaatt gaaattgtga
    10441 aagaaagagg tgctaatcta ttatctcgac tctatcgtta tcaagatagt cagggaatta
    10501 gtattgatga tgaatctaat ccttggattt taatgagtga tgatctatct gacttgattc
    10561 agacaaatat ctatttagta gaaaattttg atgaaataga gagatatagc ggctatttgg
    10621 atggaattga acgtatgtta gagatatctg aaaagcggat ggtagcttaa tggaaatcca
    10681 agattatact gatagtgaat tcaaacatgc tttagcaagg aatcttcgtt cactgacaag
    10741 aggaaaaaag tccagtaaac aacctatagc gattttgctt ggaggtcaaa gtggtgccgg
    10801 taagactaca attcatcgta ttaaacagaa agaatttcaa ggaaatattg ttatcataga
    10861 tggtgatagt tttcgttctc agcatccaca ctatttagaa ctgcagcaag aatatggcaa
    10921 agacagtgta gaatacacca aagattttgc agggaaaatg gtagagtctt tagtaaccga
    10981 attgagtcat ttgggataca atcttttgat agagggaact ttacgaacta ttgatgttcc
    11041 aaagaaaaca gcacaactat taaaaaataa ggggtatgag gtacaattag ccttaattgc
    11101 aaccaagccc gaattgtcct atctgagcac ccttatccga tacgaagaac tgtatgctat
    11161 caatccaaat caagcacgcg caactccaaa agaacatcat gatttcattg taaatcatct
    11221 agttgataat acacgacaat tggaagaact ggctatcttt gaaagcattc aaatttacca
    11281 acgagataga agttgtgtat atgattcaaa agaaaataca acttcagcag caaccgttct
    11341 tcatgattta ctatttggag aattgaatca agtggagaaa gagatgctta aatcaggaga
    11401 agaaagattg aaagatttaa ctaattgaaa tggttgttag aacacaaatt ttagaatata
    11461 gtctacttat aacttttgtt agttgtttga ggtgggcaaa aagtttttaa aatcaaaaaa
    11521 aacgcatagt atcaggtgtt gaaaaaactt gatattatgc gttttcttgt tggaagattt
    11581 actccatttt cttcaggaat tgagattttg cccatctctt tttattatat ttaaggatat
    11641 ttgaaagctg tattttagaa aaacaaatat ggagttttta atacggacgt aatatagtat
    11701 aaatgctgat tcaaagtgaa gttttatatg ttttttgctt ttgttgagta taaaatctat
    11761 taactaaagt cgaactacaa acattgattt aagataaagt aaactgtaac cttcagaaat
    11821 gtctcttact cgatttcaga atgaatcact gacataggat taaaagaact aagtatttct
    11881 ttttgttttg aatgagatac gtgagtatag atttgtgtga ctgatataga actgtgtcca
    11941 agaatttgtt gaatgtatcg aatatctaca tcattatcta gaagcattgt tgcaaagcta
    12001 tgtctaaata tatgtggtgt aatagtttta gataagctat tttgttcaac gattctcttt
    12061 aaaattaaac gtacactttg ctctgacaat ggtttaggca aatgtttccc tgggaatagg
    12121 aaatcattag attcctttcc ggttttattt atatatgttt ctaatatatt gaaggtcgtt
    12181 tgatctccta aaaataggat acgctctttc ttcccctttc ctataatatg tagtgtctta
    12241 ttggaaagat taatatcttt gagatgaata tgacaaagtt cagaaattct gatacccgtt
    12301 gaaagtaaaa gggaaataat aagtagattt ctttcagctt tttgtttttg atagtcagtt
    12361 ttagatataa ctactttctg ttctaaatat ataaaaatgt ttttcagaat gtcatacgga
    12421 atcgttttag gcaatatttt ttcagttcta aattgaaaac gcaattgatt gaaggggttc
    12481 tcttcaatta tgttctggta ttttagatag ttataaaaca ccttcataca agcaattttt
    12541 cttcttaatg tattcgtttt tatgttagat tgtgtcaaat gttctatata ggattcgaca
    12601 tgatcatagt ctgagttata aaattgcata agatcattct tataagcgcg aatcgtgtgt
    12661 gaactcaaac gcttatgagt tttgcaataa tctaagtaag tagaaataag tttataatcc
    12721 ataaaaatct cctttatcaa taatcatgct attataaacc tatttgggtg ctttgtatag
    12781 tgataataaa ttgttatcac tagtatacca taaattcatt tttagtagtt tgatttgtat
    12841 aatgattttt tagtcttgaa ttgtcacatt aagtgcacat tttctcttgt gaatttagat
    12901 aaggatattt aatttataaa aggaaatttt atagtatagt tgtgattttt atattttcag
    12961 tttaagcaaa atagtggtgg tatgctatat gtttttcttt gttaatggta taatgtaata
    13021 tatagagaga gttatttatc gaggttagaa tttggcaaat aatagacaaa ttgagacatt
    13081 aggtgtttcc tatctgacaa cattcataaa tagacatagt ttacttcaga cttattttgg
    13141 tagtaatgat aaaactccag tctgggatgg tgagattcat gttcttaaaa cttctagtga
    13201 gaaaagaagt gaaatatttg gtaaagtgcc tgttcaaatt aaagctacaa ggcaacagaa
    13261 gaataaattg aaatccttct cgttggacat aagtgattta gaattatatt caaaaaatgg
    13321 tggtgtagtt ttattcgtag tttggttaag cgaggatggt gatttaagaa atatctacta
    13381 taaatcatta cctcctcttt ctataaagaa gctgattaaa aaaagtaatt taaaaaataa
    13441 aacaacaagc agtaagaaac tttctgtaca gattcatgaa ttagacgaac aaaaactgta
    13501 ccctatgcta gtcgatttta taacaaatag tcgtaagcaa tatagcttca taaatgttga
    13561 tggtatttca gttgaagata tctctgatga tagtaacctt aaattctatt attatggtca
    13621 agaaaaagga gagatcttta actatcagga agaaaatgat ctcttcattt attataaaaa
    13681 tcctttaact ggtattgaag taccacttga aaatacaata aaggttgtcg aaacttacga
    13741 ggaaacagat ctaattatta caatagggaa tactattttt caaaatgtaa aaaggcatag
    13801 attccctgat gggagtgtac aactccattt tggtgaaggt tttaaaatgt catttgatgt
    13861 taagaagaaa caattcacat ttaactacac aagacctaat atgttatcaa aagccataaa
    13921 gtgcactcag gcatttcaag aactaggaaa attcggatat tgcaagctca atggtaatat
    13981 aatagaacta gatgaacagt caatattgga tattacttca cgtgatttag agactgagat
    14041 agaggaattg gtacagattt caaacttcat ggaaaatatg aggatacaaa aagaggttga
    14101 tctaacttac tttgataaac aatctctaag aaatctaaat attctcaatt taggccttat
    14161 tctaaagaat aaagttgcct taaattataa tgaatcaaaa ttacttcacc taagaattgc
    14221 taatatccac attattacct tatatgactt tgagacagat aatattggaa ctatgataga
    14281 catttttact gaaactcctt ggtgtaggag aggtgaaggt gaagattcgt cctacatttc
    14341 aatctttgaa gttttagaac caaatgactg gctaaaaata gataattgtg attttgattc
    14401 ggttatctcc tcttaccaaa gattagttga taatggcttg aaatttgaag atgctaacaa
    14461 cactattata aaaatagtta ttgctgctga taaggcagaa gatgtttcca gaagtgagtt
    14521 attgcttaat tgggcacaat gtctttctga ctggaactta aaatactcaa aaaattgtga
    14581 gatggctata ataaatgacc ttcaaataaa atctagagtt cgtaaattaa acagcaaaga
    14641 aatggagatt ctgagtaaca ttttagtaaa tagtaatgat aactatgaac tttgtttcgg
    14701 ttcatcagtg ttattaaaat cgaaaccaca agctgatttg ttctggaata aacttgataa
    14761 tgagacaaaa gaaagctata aagaatttcc tatttatact ttgtatatga aattattgta
    14821 aaattaaaag aggctggaag aaaaaatata tggaaataaa gaaagtaatg tattacaata
    14881 cagtgccaca atttttaaaa cctaaattaa attattttgc aagagatttt ctaaatgatt
    14941 attctgttca gatagaagac attgaagcag gttctaattt tgaagttgat gtagagtatg
    15001 aaggcaattt agaagtttat tttgtcaaat ttatgtttag aaaaaaaggt ggtggaatgt
    15061 ttagtggtaa ttctgaaaat gaattag
//
LOCUS       DAVLHC010000043        14205 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.044, whole genome shotgun sequence.
ACCESSION   DAVLHC010000043 DAVLHC010000000
VERSION     DAVLHC010000043.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 14205)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14205)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14205
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.044"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            83..880
                     /locus_tag="VXE25_001635"
     CDS             83..880
                     /locus_tag="VXE25_001635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000254803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate/nitrite transporter family protein"
                     /protein_id="HEV0772067.1"
                     /translation="MISSEFISKIEFACNKKEGLYSQSKFKYAIRSMFAGAFLTFSTA
                     AGAVGADLINKIAPGSGRFLFPFVFAWGLAYIVFLNAELVTSNMMFLTAGSFLKKISW
                     RKTAEILLYCTLFNLIGALIAGWGFAHSAAYANLTHDSFISGVVEMKLGRSNELVLLE
                     AILANIFVNIAILSFILVKDGGAKLWLVLSAIYMFVFLTNEHIAANFASFAIVKFSVA
                     ADSIANFGVGNMLRHWGVTFIGNFIGGGLLMGLPYAFLNKNEDTYVD"
     gene            1028..2288
                     /locus_tag="VXE25_001636"
                     /pseudo
     CDS             1028..2288
                     /locus_tag="VXE25_001636"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018365067.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="O-acetylhomoserine
                     aminocarboxypropyltransferase/cysteine synthase"
     gene            2384..3658
                     /locus_tag="VXE25_001637"
     CDS             2384..3658
                     /locus_tag="VXE25_001637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001002592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2130 domain-containing protein"
                     /protein_id="HEV0772068.1"
                     /translation="MNEIKCPNCGEVFTVNESQYAELLSQVRTAEFDKELHDRMRQEL
                     ALAEQKAMNEQQTKLAQKDQEIAQLQSQIQNFDTEKELAKKEVEQTSHQALLAKDKEV
                     QALENQLATLRLEHENQLQKTLSDLEKEHDQVKNQLLLQEKENELSLASVKQNYEAQL
                     KAASEQVEFYKNFKAQQSTKAIGESLEQYAESEFNKVRSFAFPNAYFEKDNKVSSRGS
                     KGDFIFRECDENGVEIISIMFEMKNEADGTEKKHKNADFYKELDKDRREKNCEYAVLV
                     TMLEADNDYFNTGIVDVSHEYEKMYVVRPQFFIQLIGLLRNAALNSLKYKQELALVRE
                     QNIDITHFEEDLDAFKLAFAKNYNSASTNFGKAIDEIDKAIKRMEEVKKFLTTSENQL
                     RLANNKLEDVSVKKLTRKNPTMKAKFEALKGE"
     gene            3668..4546
                     /gene="truB"
                     /locus_tag="VXE25_001638"
     CDS             3668..4546
                     /gene="truB"
                     /locus_tag="VXE25_001638"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007516878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA pseudouridine(55) synthase TruB"
                     /protein_id="HEV0772069.1"
                     /translation="MNGIINLKKEAGMTSHDAVFKLRKILGTKKIGHGGTLDPDVVGV
                     LPIAVGKATRMVEFMQDEGKIYEGEITLGYSTTTEDASGEVIAETPVLSPLDEKLVDE
                     AIASLTGPITQIPPMYSAVKVNGRKLYEYARAGQEVERPERQVTIYQFERTSPISYDG
                     QLARFTFRVKCSKGTYIRTLSVDLGEKLGYAAHMSHLTRTSAAGLQLEDALALEEIAE
                     KVEAGQLDFLHPLEIGTGDLVKVFLTPEEATEVRFGRFIELDQTDKELAAFEDDKLLA
                     ILEKRGNLYKPRKVFS"
     gene            4787..5089
                     /locus_tag="VXE25_001639"
     CDS             4787..5089
                     /locus_tag="VXE25_001639"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000985087.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin immunity protein"
                     /protein_id="HEV0772070.1"
                     /translation="MMRNEFRERVEQLLQQKEINENSELSHLFRLAIQNLDRNEKYQT
                     VMANLSQGLSLYLMTHHYQAPKSVIDFGLWIAKAPSQERGRLAFLQMLAQTLQGFR"
     gene            5197..5835
                     /gene="udk"
                     /locus_tag="VXE25_001640"
     CDS             5197..5835
                     /gene="udk"
                     /locus_tag="VXE25_001640"
                     /EC_number="2.7.1.48"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uridine kinase"
                     /protein_id="HEV0772071.1"
                     /translation="MQNRPIIIGVTGGSGGGKTSVSRAILSHFPDEKISMIEHDSYYK
                     DQSHLTFEERVKTNYDHPFAFDTDLMIEQIKELLAGRPVDIPTYDYTEHTRSSKTYRQ
                     EPQDVFIVEGILVLEDKRLRDLMDIKIFVDTDDDVRIIRRIKRDMEERGRSLDSVINQ
                     YLGVVKPMYHQFIESTKRYADIVIPEGVSNTVAIDLLTTKIAKILEEARNSK"
     gene            5963..7303
                     /locus_tag="VXE25_001641"
     CDS             5963..7303
                     /locus_tag="VXE25_001641"
                     /EC_number="3.1.11.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000417449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="HEV0772072.1"
                     /translation="MEKYLSVTTLTKYLKMKFDKDPYLERVYLTGQVSNFRKRPTHQY
                     FSLKDDHAVIQATIWSGIYQKLGFDLEEGMKINVIGRVQVYEPSGSYSIIIEKAEPDG
                     VGALAIQFEQLKKKLTEEGLFQERFKQALPQFSKRIGVVTSRSGAVIRDIITTVSRRF
                     PGVDILLYPTKVQGEGAAEEIARNIARANQRDDLDLIIIGRGGGSIEDLWAFNEEIVV
                     RAIFESRLPVISSVGHETDVTLADFVADRRAATPTAAAELATPVTKLDVLAHLQNQEK
                     RMATAVRNVLSKKQEALKKCSQSVIFRQPERLYDGYLQRLDQLQLRLKQSLRTRISDN
                     KQLVQARTHQLVQLSPVTKIQRYQDRLGQLDKLLGSQMALVYDAKVAEAKRLSEALLM
                     LDTSRIVARGYAIVKKEESIVDSVESLKKKDQVTLLMRDGQVELEVKDVKTKEI"
     gene            7281..7493
                     /locus_tag="VXE25_001642"
     CDS             7281..7493
                     /locus_tag="VXE25_001642"
                     /EC_number="3.1.11.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="HEV0772073.1"
                     /translation="MSKQKKFEENLAELETIVQSLENGEIALEDAITAFQKGMVLSKE
                     LQATLDKAEKTLVKVMQEDGTESDFE"
     gene            7490..8365
                     /locus_tag="VXE25_001643"
     CDS             7490..8365
                     /locus_tag="VXE25_001643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyprenyl synthetase family protein"
                     /protein_id="HEV0772074.1"
                     /translation="MKKQEKLALVESVLEDFYGDQQFASSLRESVLYSIHAGGKRIRP
                     FLLLEVLEALQVAIKPAHAQVATALEMIHTGSLIHDDLPAMDDDDYRRGRLTNHKKFG
                     EAMAILAGDALFLDPYALIAQADLPSQIKVDLIASLSLASGSLGMVAGQVLDMEGEHQ
                     HLSLEELQTIHANKTGKLLAYPFQAAAIIAELSPEMQVKLKTVGELIGLAFQVRDDVL
                     DVTASFEEIGKTPQKDLQAEKSTYPALLGLEESIVFCNQTLDQANEKLEEIAQQVPFE
                     TESIVSVVESLRING"
     gene            8358..9173
                     /locus_tag="VXE25_001644"
     CDS             8358..9173
                     /locus_tag="VXE25_001644"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001041085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TlyA family RNA methyltransferase"
                     /protein_id="HEV0772075.1"
                     /translation="MAKERVDVLAYKQGLFETREQAKRGVMAGLVVAVLNGERFDKPG
                     EKIPDDTELKLKGEKLKYVSRGGLKLEKALQVFDLSVDGATTIDIGASTGGFTDVMLQ
                     NSAKLVFAVDVGTNQLAWKLRQDPRVVSMEQFNFRYAEKTDFEQEPSFASIDVSFISL
                     SLILPALHRVLADQGQVVALVKPQFEAGREQIGKNGIIRDAKIHQNVLESVTAMAVEA
                     GFSVLGLDFSPIQGGHGNIEFLAYLKKEKSASNQILAEIKEAVERAHSQFKNE"
     gene            9166..9597
                     /locus_tag="VXE25_001645"
     CDS             9166..9597
                     /locus_tag="VXE25_001645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001034407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine repressor"
                     /protein_id="HEV0772076.1"
                     /translation="MNKKERLEKIRRLVTDYQIGTQEEIVEHLKEAGITATQATVSRD
                     IKELGIVKIPLRDNTYVYELPKSIVKSLQLAEDNIESAELMDKMINLQVIPGNTAFVK
                     AQLIETFADKIFSCLTDDSSILVIARSGSLAEEIFEQVKNW"
     gene            9604..11271
                     /gene="recN"
                     /locus_tag="VXE25_001646"
     CDS             9604..11271
                     /gene="recN"
                     /locus_tag="VXE25_001646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RecN"
                     /protein_id="HEV0772077.1"
                     /translation="MLLEISIKNFAIIEAISLNFEKGMTVLTGETGAGKSIIIDAMNM
                     MLGARATTDVIRHGAPKAEIEGLFSVENSRLLQEIFDEQGLELGDEIIIRREILQNGR
                     SISRVNGQMVNLSVLRAIGQHLVDIHGQHDHEELMRPQLHIQMLDEFGDAAFWDLKET
                     YQTSFDAYRKMRKQVLEVKKNQQEHKARIEMLEFQMAEIEAANLQAGEDLALNQERDK
                     LLNHKNIADTLTNAYSMLDNEDFSSLANVRSAMNDMESVEEYDPEYREISSSLSEIYY
                     VLEDISKRLEAIIEDLDFDGNRLMQVENRLDLLHTITRKYGGTVDDVLLYFAKITEEY
                     NLLTGNNLSSEDMEAELKKLEVNLVNLAGQLASARHNLAQQLEAEIKQELQDLYMEKA
                     QFQVRFSKGKFSREGNEMVEFYISTNPGEDFKPLVKVASGGELSRLMLAIKSAFSRKE
                     GKTSIVFDEVDTGVSGRVAQAIAQKIHKIGQHGQVLAISHLPQVIAIADYQFFIEKIS
                     NDHSTVSTVRLLTVEERVEEVAKMLAGDDVTEAALTQARELLRNREK"
     gene            11273..12001
                     /locus_tag="VXE25_001647"
     CDS             11273..12001
                     /locus_tag="VXE25_001647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000133310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine/threonine protein phosphatase"
                     /protein_id="HEV0772078.1"
                     /translation="MTDYYVIGDVHGKAGMLEDLLKTWDGQTQLLFLGDLIDRGEDSH
                     RVLEMVKDLVDNQGAICLSGNHEYMFLTWLDDPEESYDHYRRNGGDTTINSILGRPLD
                     APVDGVEDAKRVAAEAADLVEFIRQMPFVVETDKYIFVHAGIDLTLDDWHETTDYKKV
                     WLRKPFHGAENHTGKTIVFGHTPVYGLLQQERGTSELWTTEDGKIGMDGGAVYGGVLH
                     GIVFTDQGMTEHHFIENDGFVAED"
     gene            12080..13903
                     /gene="lepA"
                     /locus_tag="VXE25_001648"
     CDS             12080..13903
                     /gene="lepA"
                     /locus_tag="VXE25_001648"
                     /EC_number="3.6.5.n1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001047203.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor 4"
                     /protein_id="HEV0772079.1"
                     /translation="MNLEELKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSRE
                     MQAQLLDSMELERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLA
                     ACEGAILVVDAAQGIEAQTLANVYLALDNDLEIMPIINKIDLPAADPERVRTEIEDVI
                     GLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDVTAPLKALIFDSVYDAYRGVILQ
                     VRVMDGVVKPGDKIQLMSNSKTFDVAEVGIFTPKAVGRDFLATGDVGYIAASIKTVQD
                     TRVGDTVTLATNPAAEPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQ
                     FEPETSQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVIYKVNLTDGESMD
                     VSNPSEFPDPTKIATIEEPYVKAQIMVPQEFVGAVMELAQRKRGDFVTMDYIDDNRVN
                     VIYQIPLAEIVFDFFDKLKSSTRGYASFDYELSEYRPSKLVKMDILLNGDKVDALSFI
                     VHKDFAYERGKLIVDKLKKIIPRQQFEVPIQAAIGHKIVARTDIKALRKNVLAKCYGG
                     DVSRKRKLLEKQKAGKKRMKSIGSVEVPQEAFLSVLSMDEE"
     gene            complement(13984..>14205)
                     /locus_tag="VXE25_001649"
     CDS             complement(13984..>14205)
                     /locus_tag="VXE25_001649"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772080.1"
                     /translation="DETDEVSSKHGFEVVDETDEVSSKHGFEVVDETDEVSSKHGFEV
                     VDETDEVSNHTYGKATMTWFEEIFEEYKN"
BASE COUNT         4194 a         2602 c         3373 g         4036 t
ORIGIN      
        1 acttttatga aatacagaaa acgcttccta aaacctaaag tttgtgatat aattatcaag
       61 aaaaaagatt taggagttta ttatgatttc ttcagaattt atctcaaaga ttgaatttgc
      121 ttgcaataag aaagaaggtc tttatagtca aagcaaattt aagtatgcga ttcgttcgat
      181 gttcgcaggt gcatttttaa ccttcagtac tgctgcaggt gcagttgggg ctgacttgat
      241 taataaaatt gcaccaggta gtggacgctt cctctttcca ttcgtttttg cttggggctt
      301 ggcctacatt gtttttttga atgccgagtt ggtcacttca aacatgatgt tcttgactgc
      361 tggtagtttc ttaaaaaaaa tctcttggag aaaaacagct gagattttac tatactgtac
      421 cttgttcaac cttatcggag ccttgatagc agggtggggc tttgctcatt cggcagccta
      481 tgcgaatctg acacacgata gtttcatctc aggtgttgtt gagatgaagt taggccgctc
      541 aaatgaattg gtcttgcttg aggcgatttt ggcaaatatt ttcgtaaata ttgcgattct
      601 gtcatttatt ttggtcaaag atggtggtgc caaactttgg cttgtgttgt cagctattta
      661 catgtttgta ttcttaacaa acgagcacat tgcggcgaac tttgcttctt tcgcgattgt
      721 gaaattcagt gttgctgcgg attcaattgc caacttcggt gttggaaata tgcttcgcca
      781 ctggggtgtg actttcatcg gaaactttat cggaggaggc ctcttgatgg gtcttccata
      841 tgccttcctc aataaaaacg aagatactta tgtagattaa gaaaatgagc acgattgagt
      901 cgtgcttttt tcattttcaa aataaggtaa cagctatttc ttatatcaaa atatagaaaa
      961 ctgatatttg taaactataa ctcaaggtgc tacaatatcc ttaataaaat aatatggagg
     1021 tcaccttatg acttgtgatt ttaaatttga aactctacaa ctacatgctg gtcaagttgt
     1081 ggctccagct actaagtctc gtgcagtgcc gatttaatca aacaacattt tttgtttttg
     1141 atgacacgta ggaaggtgcc gatatgtttg ccttgaggaa accagggaac atttatactc
     1201 gtatcaccaa tcctacaaca gctgcccttg aaggtggtgt tgaagcgcta gcaacagcat
     1261 caggtatgac tgcagtgact tatacgattt tggcgcttgc ccatgctggt gaccatgtag
     1321 tggctgcttc gactatttac ggtggaacct tcaatctttt gaaagaaccc cttcctcgtt
     1381 atggtatcac aacaaccttt gtcgatattg ataatttgga ggaagtagaa gcagctatca
     1441 aagacaatac caagcttgtc ttgattgaaa ccttgggtaa ccccttgatt aatattccag
     1501 acctggaaaa actggcagag attgctcata aacatcaaat cccacttgtg tcagacaata
     1561 cttttgcaac accttatttg attaacgtct tctctcatgg cgttgacatt gccattcact
     1621 ctgcgactaa gtttatcggt gggcatggta caactattgg aggaataatt gtcgatagtg
     1681 gtcgttttga ctggacggct tcagggaaat tccctcaatt tgttgacgag ggtccaagct
     1741 gccacaattt gagctatact cgtgatgtgg gtgcagcagc ctttattata gctgttcgag
     1801 ttcaattgct tcgtgataca ggtgcagcct tgtcaccatt caatgctttc ctcttgctac
     1861 aaagacttga aaccctttca cttcgtgtgg aacgccatgt acaaaatgct gagacaattg
     1921 ttgattttct tgtcaaccat cctaaggtag aaaagataaa ttatccaaaa cttgcagata
     1981 gtccttatca tgccttggct gagaaatact tgccaaaagg tgtcggttca atctttacct
     2041 tccatgtcaa aggtggcgag gaagaagcac gcaaggtcat tgataatttg gaaatcttct
     2101 cagaccttgc taacgtggca gatgccaagt ctcttgttgt tcatccagca acaaccactc
     2161 atggtcaatt gtcagaaaaa gacctagaag cagcaggtgt cacaccaaat caaatccact
     2221 tgtctatcgg acttgaaaat gtagatgatt tgattgaaga cttgcgcttg gccttggaaa
     2281 aaatttaaag aaaaagaaga taaacagtgg ttttcgactc gctgtttttg attttccttc
     2341 atgcatgata taatggttac agaagtctag aaagaggaat gtaatgaacg aaatcaaatg
     2401 tcccaactgt ggggaagtct ttacagtaaa tgaaagccag tatgctgaac ttttgtccca
     2461 agtgagaacg gcagagtttg ataaggaact acacgatagg atgaggcagg aactggcctt
     2521 ggctgagcaa aaggctatga atgagcaaca gactaaactg gctcagaagg atcaagaaat
     2581 tgcgcaatta cagagtcaga tccaaaactt tgatacagaa aaagaattgg ccaagaaaga
     2641 agttgaacag acaagccatc aggccttatt ggctaaggac aaggaagtac aggctttgga
     2701 gaaccaattg gccactttgc gtttggagca tgaaaatcaa ctgcaaaaga ccctttctga
     2761 cctagaaaaa gaacatgatc aggtcaaaaa tcagctcctc ttgcaagaaa aggaaaatga
     2821 gttgtctttg gcttctgtta agcaaaacta tgaagcccag cttaaagcag ctagtgaaca
     2881 agtcgagttt tataagaatt ttaaggctca acaatctaca aaagcgattg gggaaagcct
     2941 agaacagtat gcagagagtg agtttaacaa ggttcgtagt ttcgcctttc caaatgctta
     3001 ctttgagaag gataacaagg tctcttcgcg tgggtctaaa ggggacttta tcttccgtga
     3061 gtgtgatgaa aatggagttg aaatcatttc tatcatgttt gagatgaaaa acgaagcgga
     3121 cggaacagag aagaagcaca agaatgcaga tttttacaag gaattggaca aggaccgtcg
     3181 ggagaagaac tgtgagtatg ccgttttggt gaccatgctt gaggccgata atgactactt
     3241 taacacaggg attgttgacg tcagccacga gtatgaaaaa atgtatgttg ttcgtcctca
     3301 attctttatc cagttgattg gtctcttacg taatgcggcg ctaaattccc taaaatacaa
     3361 gcaggagttg gccttggttc gcgagcaaaa tattgacatt acgcattttg aggaagattt
     3421 ggatgccttt aagctagctt ttgctaagaa ctataattca gcttcgacta actttggaaa
     3481 agctattgat gaaatcgaca aggccatcaa acgcatggaa gaggttaaga aattcctgac
     3541 cacatctgaa aaccaactcc gtctagctaa caacaaattg gaagatgtct ctgttaaaaa
     3601 attgacccgg aaaaatccaa caatgaaagc gaagttcgaa gcactgaagg gggagtagaa
     3661 agcaaaaatg aacggtatta tcaacttaaa aaaagaagca ggaatgacct cgcatgatgc
     3721 ggtttttaaa ctgcgtaaga ttttgggaac caagaaaatt ggtcatggtg gaaccttgga
     3781 tccggatgtg gtgggtgttt tgccgattgc ggttggcaag gcgacacgca tggtcgagtt
     3841 tatgcaggac gagggtaaga tctatgaggg ggaaattact ctgggttatt ccacgacgac
     3901 tgaggatgct agtggggaag tgatcgcaga aacccctgtt ttgtctccct tggatgaaaa
     3961 gcttgttgat gaagcgattg ctagcttgac tgggcctatt acccagattc cccctatgta
     4021 ttcggcagtt aaggttaatg gtcgcaagct ctatgagtat gcgcgtgctg gtcaggaagt
     4081 ggagcgtcca gaacgtcagg tgaccattta tcaatttgag cgaacaagtc cgatttctta
     4141 tgatggccaa cttgcccgat tcacttttcg tgtaaaatgc agtaaaggga cttacatccg
     4201 tactttgtca gttgatttgg gtgaaaagct tggttatgcg gctcatatgt cccatttgac
     4261 tcgtactagt gctgctggct tacaattaga agacgctctt gccttggagg aaattgctga
     4321 aaaagtagag gctgggcaat tagattttct ccatccttta gagattggga caggtgacct
     4381 tgtcaaagtt ttcctaactc cagaagaggc tacagaagtt cgctttggtc gttttattga
     4441 gctagaccaa acggacaaag aactggctgc ctttgaagat gataaattgt tagccattct
     4501 agaaaaacgg ggcaatctct ataagccaag gaaggttttt agctagatcg tttaggaata
     4561 aaaatcgggt gatagataac aattgcttga taaaacccca tactaatagt agaatggttt
     4621 tgggaattat aatattccaa ttgttgcgag ttgtaggtac tcaaataatc tatatagaaa
     4681 tttagaggtg tgaaatgaag caatttaaaa ttctttcaga taaatattta gagtccatta
     4741 caggttctgg tgggaactta ggcccaggat ttggtgtgat aattccatga tgcgaaatga
     4801 gtttcgagaa agggtggagc aacttcttca acaaaaagaa ataaatgaaa atagtgagtt
     4861 gagtcacctg tttcgtcttg ctatacaaaa tttagacaga aatgaaaaat accaaacggt
     4921 catggccaat ttgagtcaag ggttgtcact ttacctcatg acgcatcatt accaggcacc
     4981 taagtctgtc attgattttg gtttatggat tgccaaagct cctagccagg aaagagggag
     5041 actggctttc ttgcagatgc ttgctcaaac cctacagggc tttcgttaaa actgtcgaac
     5101 atcagaggga agactctggt gttttttgct gatgagacta taaattttgt aaaaaatgtg
     5161 atagaataga cgacggataa aataacggag gatagcatgc aaaatagacc aatcattatt
     5221 ggagtgacag gtggttctgg tggtggtaaa accagtgttt caagagccat tttatcgcat
     5281 tttcctgatg aaaagatttc catgattgag catgattcat actacaagga tcagtctcat
     5341 ttgacctttg aagagcgtgt caaaaccaac tatgaccatc cttttgcctt tgatacagac
     5401 ttgatgatcg agcagattaa ggaattgttg gcagggcgtc cggtggacat cccgacctac
     5461 gactatacag agcatacacg gagtagcaag acctatcgtc aggagcctca agatgtcttt
     5521 atcgttgagg gcattttggt cttggaggac aagcgtctgc gcgatttgat ggatatcaag
     5581 atttttgtgg atacggatga cgatgtgcgt attattcgtc gtatcaagcg tgatatggag
     5641 gaacgtggcc gtagccttga tagcgttatt aaccagtact taggtgtggt caaaccaatg
     5701 taccaccagt ttatcgagtc aactaagcgt tatgctgata tcgtcattcc tgaaggggtt
     5761 agcaataccg tggctatcga cctgttgacg accaagattg caaagatttt ggaagaagct
     5821 cgaaacagca aataatcaca tgtggaggcc ttgcctcctt tttctatttt tccctcataa
     5881 tggtacataa atggagattt ttaggcatat ttttggtata ataataccca taaaagagca
     5941 agtaaatgaa tagtaggtgg agatggaaaa gtatttatcg gtaacaactt tgaccaaata
     6001 tctgaaaatg aaattcgata aagacccata cttggaacgg gtctatttaa ctggtcaagt
     6061 ttccaacttt cgtaaacgac ctactcacca atatttctcc ctaaaggatg accatgcagt
     6121 tattcaagcg accatctggt ctgggattta tcagaaatta gggtttgacc tggaagaagg
     6181 aatgaagatc aatgtgattg ggcgtgtaca ggtctatgaa ccaagtggta gctactccat
     6241 catcattgaa aaagctgagc ctgatggggt tggggcgctt gcgattcagt ttgaacaact
     6301 taagaaaaaa ttgacagaag aaggtctgtt tcaagaacgc ttcaagcaag ctctacccca
     6361 attttctaag agaattgggg tggtaaccag ccgtagtgga gccgttattc gagatattat
     6421 cacaaccgtc agcaggcgat tcccaggtgt tgacatcctt ctttatccga ccaaggttca
     6481 aggtgaaggg gctgcggagg aaattgctag aaatattgcg cgtgctaatc aacgggacga
     6541 tttggatttg atcattattg gtcgtggagg tggttctatt gaggatctct gggcctttaa
     6601 cgaagaaatt gtggtacgag ctatttttga atctcgtttg ccagttatct ctagtgtggg
     6661 gcatgagacg gatgtgacct tggcagattt tgtggcagat cgacgcgctg caacgccaac
     6721 agcggcggct gaactggcaa cacctgtgac caagttggat gtattagctc atttgcaaaa
     6781 tcaggaaaaa cggatggcaa cggcagtccg aaatgttcta tctaagaaac aagaggcttt
     6841 gaaaaaatgc agtcagtctg ttatctttag acaacctgag cgcttgtatg acggttattt
     6901 gcaacgcttg gaccaactgc aactgcgttt gaaacaaagt ttgcgaactc ggatttctga
     6961 taacaaacaa ttagttcaag caagaactca tcaattagta caattatcac ctgttaccaa
     7021 aatccaacgc tatcaagacc gtttaggaca gttggacaag ctcttaggta gccaaatggc
     7081 gttagtttat gacgccaagg ttgctgaggc caagcgactt tcggaagctt tgctcatgtt
     7141 ggatactagc cgaatcgtgg cgcgtggtta tgctattgtc aaaaaagaag agtccattgt
     7201 agattcggtt gagagtttga agaaaaaaga ccaagtaacg cttttgatgc gagatggtca
     7261 agtagaatta gaggttaaag atgtcaaaac aaaagaaatt tgaggaaaat ctagcagaac
     7321 tggaaaccat tgtccaaagt ttggaaaatg gtgaaattgc tctggaagat gcgattactg
     7381 cctttcaaaa gggcatggtc ttgtcaaaag agctccaagc tacgctggac aaggctgaaa
     7441 agaccttggt aaaggtcatg caagaagacg gaacagaaag tgattttgaa tgaaaaagca
     7501 agaaaaatta gctcttgtcg agtcggtttt ggaagatttt tatggagacc agcagtttgc
     7561 ctctagttta cgggagtctg ttctctattc tattcatgct ggtggcaagc gtattcggcc
     7621 ttttctcttg ttagaagttc tggaagcctt gcaggttgcc atcaaacctg ctcacgcgca
     7681 ggtagctact gccttggaga tgattcatac agggagcttg attcacgatg accttcctgc
     7741 tatggatgat gacgattatc gaagagggcg gttaaccaat cacaagaaat tcggtgaagc
     7801 tatggccatt ttggctggag atgccttatt cttagaccca tatgccttga ttgcgcaggc
     7861 agatttgcca agtcagatca aggtggactt gattgccagc ttatcccttg cttcaggtag
     7921 tctgggtatg gtggcagggc aagttttgga tatggagggc gaacaccagc acttgtctct
     7981 ggaagaactt cagactattc atgccaataa gactgggaag ttactagcct atcccttcca
     8041 agcggcagct attatagctg aattgtcacc tgaaatgcag gtgaagctga aaactgtggg
     8101 tgaattgatt ggacttgctt ttcaagtcag agatgatgta ctggatgtga cagctagttt
     8161 tgaggaaatc ggtaagacac ctcaaaagga tctgcaggca gaaaaatcaa cctatcctgc
     8221 cttgttgggc ttggaagagt ccattgtctt ttgtaaccaa accctggatc aagctaatga
     8281 aaaattggaa gaaattgccc agcaggttcc ctttgaaaca gaatcgattg taagtgtagt
     8341 agaaagtttg agaatcaatg gctaaggaaa gagtggatgt actagcttat aaacaggggt
     8401 tgtttgaaac gagagagcag gccaagcgag gtgtgatggc tggcctagtc gtagcagtcc
     8461 ttaatggaga acggtttgac aagccaggag agaaaattcc agatgacacc gaattaaaac
     8521 tcaaggggga gaaactcaag tatgtcagcc gtggtggttt gaaactggaa aaggccttgc
     8581 aggtctttga tttgtcggtg gatggcgcga ctacgattga tatcggggcc tctactggag
     8641 gttttaccga tgtcatgcta cagaatagtg ccaagttggt ctttgcagtc gatgttggta
     8701 ccaatcagtt ggcttggaaa ttacgccaag acccacgagt tgtcagcatg gagcaattca
     8761 attttcgcta tgctgaaaag actgatttcg agcaggagcc gagctttgcc agtattgatg
     8821 tgagtttcat ttcccttagt ctgattttgc cagccttgca ccgtgtcttg gctgatcaag
     8881 gtcaggtggt agcacttgtc aaacctcagt ttgaggcagg acgtgagcag attgggaaaa
     8941 atggaattat tcgagatgct aagattcatc agaatgtcct tgaatctgta acagctatgg
     9001 cagtagaggc aggtttttca gtccttggct tggacttttc tcccatccaa ggtggacatg
     9061 gaaatattga atttttagcg tatttgaaaa aagaaaagtc agcaagcaat cagattcttg
     9121 ctgagattaa agaagcagta gagagggcgc atagtcaatt taaaaatgaa taaaaaagaa
     9181 agacttgaaa aaattagaag attggtgaca gattatcaaa tcggcacgca agaagaaatt
     9241 gtagaacatt tgaaagaagc aggtatcact gccactcagg cgacggtatc ccgagatatc
     9301 aaagagttag gtattgtcaa aattcctttg agagacaaca cctatgtcta cgaattgcca
     9361 aaatcaatcg taaaaagtct gcaactggct gaagacaata tcgaatcggc tgaattgatg
     9421 gataagatga tcaatctcca agttattcca ggaaatacgg cttttgtaaa agctcagtta
     9481 atcgagactt ttgcagacaa gatttttagc tgtttgactg atgatagctc gattttagtc
     9541 attgccagaa gtggaagtct agcagaggaa atctttgaac aagtaaaaaa ttggtaggtc
     9601 tatatgttac ttgaaatttc gataaaaaac tttgccatta ttgaggctat ttccctcaat
     9661 tttgaaaagg ggatgactgt cctgactggt gaaacgggtg cagggaagtc gattatcatt
     9721 gatgccatga atatgatgtt gggagctcgt gcgacgacag atgttattcg tcatggtgca
     9781 ccaaaggcag agattgaggg gcttttctca gttgagaata gtcgtctttt acaggaaatt
     9841 tttgatgagc aaggtttaga attaggtgat gaaattatca tccgtcggga aatcttgcaa
     9901 aatggtcgta gtatcagccg tgtaaatggt cagatggtta atctgtctgt tttgcgagct
     9961 attgggcaac atcttgtaga tattcatggt cagcatgacc atgaggagtt aatgcgtccc
    10021 caactgcata tccagatgtt ggatgaattt ggtgatgccg ctttttggga cttgaaagaa
    10081 acctatcaaa cgagttttga tgcctatcgg aaaatgcgca agcaggttct ggaagtcaag
    10141 aaaaaccaac aggaacacaa ggcacgtatc gaaatgttgg aatttcaaat ggcagagatt
    10201 gaggcagcaa acttgcaggc tggagaagac ttggctctca atcaagagcg agataaactc
    10261 ctcaaccaca aaaatattgc ggatacactg accaatgcct acagtatgtt ggacaatgaa
    10321 gatttttcaa gtctggccaa tgttcgttca gctatgaatg acatggaaag tgtcgaagag
    10381 tatgatcctg aataccgtga aatttcaagc tctctgtctg agatctacta tgttttagaa
    10441 gacattagca aacgtttgga agctatcatt gaggaccttg attttgatgg caatcgcctc
    10501 atgcaggttg agaatcgttt ggacctcctt catactatta ctcgtaagta tggtgggact
    10561 gttgatgatg ttttgcttta ttttgccaag attacggaag aatacaatct cttgacaggc
    10621 aataatcttt cgtctgagga catggaagca gagcttaaga agttggaagt caatcttgtc
    10681 aatttggcag gtcaacttgc ttctgctcgt cataatttgg ctcagcaact cgaagctgag
    10741 attaaacaag aactgcaaga tctttatatg gaaaaagccc agtttcaggt tcgttttagt
    10801 aagggaaaat tcagtcgtga gggaaatgaa atggttgagt tttatatttc aaccaaccct
    10861 ggagaagact ttaaaccctt ggttaaggtt gcttctggag gggaattatc tcgtctcatg
    10921 ttagccatta agtctgcctt ttcacgtaaa gaaggcaaga ctagcattgt ctttgatgag
    10981 gtggatacgg gagtttcagg tcgtgttgct caagctattg ctcagaaaat tcataaaatt
    11041 ggtcagcatg gtcaggtttt ggctatctcc catttgccac aagtaattgc gattgcagat
    11101 tatcaattct ttattgagaa gattagtaat gaccattcaa cggtttcgac tgttcgtctc
    11161 ttgacggtcg aagagcgagt ggaggaagtt gccaagatgt tggcaggtga tgatgtgaca
    11221 gaagcagccc tgacgcaagc cagagaattg ttgagaaaca gggagaaata agatgacaga
    11281 ttattatgta attggagatg ttcacggaaa agctgggatg ctggaagacc ttcttaaaac
    11341 ctgggatggt cagacccagt tgctctttct aggtgatttg attgacagag gtgaggatag
    11401 tcaccgtgtt cttgaaatgg tcaaggactt ggtggacaat caaggggcta tctgtttgtc
    11461 tggaaaccac gagtatatgt ttttgacttg gctagatgac ccagaagaaa gttatgacca
    11521 ttatcgtcgc aatggtggag atacaaccat taactctatc ctaggtcgtc ccttggatgc
    11581 accagttgat ggagtagaag atgccaagcg ggttgccgct gaagcggcag acttggtcga
    11641 attcattcgt caaatgccat ttgtagtaga gacagacaag tatatctttg ttcacgcagg
    11701 tattgatttg accttggacg actggcatga aacaacagat tataaaaaag tatggcttag
    11761 aaaaccattc cacggagctg aaaatcatac tggaaaaacc attgtcttcg gtcatacacc
    11821 ggtctatggt ttgttacagc aagaacgcgg tacatctgag ctttggacta cagaagatgg
    11881 caagattgga atggatggag gagctgttta tggtggtgtc cttcacggga ttgtctttac
    11941 agaccaagga atgacagaac accactttat cgaaaatgac ggctttgtcg ctgaagatta
    12001 gtactcctag cagggtatgg tcttgtcaaa atatcaaaaa caatttataa taaatagata
    12061 ccctgaaagg aagagaatca tgaacttaga agaattgaaa aaacgacagg agaagatccg
    12121 taacttctct attatcgccc atattgacca cggaaaatca actctagcag accgcatttt
    12181 ggaaaaaaca gagacggttt caagtcgtga aatgcaggcc cagcttttgg atagcatgga
    12241 gctagagcgg gaacgtggaa ttactattaa gttgaatgcc atcgagttga attacactgc
    12301 aaaagatggg gaaacttata ttttccactt gattgacaca ccagggcacg ttgactttac
    12361 ctatgaagtt tcacgttcgc tagctgcctg tgagggtgct attttggtgg tcgatgcggc
    12421 tcaaggaatt gaggctcaaa ctcttgccaa cgtttatctg gctttggata atgatttgga
    12481 aatcatgcct atcattaata aaattgacct gccggctgca gatccggagc gcgtgcgtac
    12541 agagattgaa gatgtgattg gtttggatgc cagtgaagca gttttggctt ctgccaaggc
    12601 tggtattggg attgaagaaa tcctcgagca aattgtagaa aaagtaccag caccaacggg
    12661 tgatgtgacg gcgccactta aggccttgat tttcgactct gtttacgatg cttaccgtgg
    12721 ggttatcctc caagtacgtg tcatggacgg agtggtcaaa cctggtgata agattcagct
    12781 catgagcaat agtaagacct ttgatgtggc cgaagtcggt atttttacac caaaagcggt
    12841 tggtcgtgat ttccttgcga ctggtgatgt tggttacatt gcggcgtcta tcaagacggt
    12901 tcaggatact cgtgtgggtg ataccgttac cttggcaacc aatcctgcgg cagaaccatt
    12961 acatggttat aagcagatga atcctatggt ctttgcgggt ctctacccaa tcgaatcaaa
    13021 caagtacaat gacctgcgtg aagcgcttga aaaattgcaa ctgaatgatg ctagtcttca
    13081 gtttgaacca gaaacatctc aggcacttgg atttggtttc cgttgtggat ttcttggact
    13141 tctccatatg gatgttatcc aggaacgttt agagcgtgag ttcaatattg acctcatcat
    13201 gacagctccg tctgttattt acaaagttaa tttgaccgac ggtgagtcta tggatgtgtc
    13261 taacccatct gagtttccag acccaactaa gattgcgacc attgaagagc cttatgtcaa
    13321 ggcgcaaatc atggtaccac aggagttcgt cggagcagta atggagctag ctcagcgtaa
    13381 gcgtggggac tttgtgacta tggactatat tgatgataac cgtgtcaatg ttatctatca
    13441 aattcctctt gctgaaattg tctttgactt ctttgataaa cttaagtctt caacacgtgg
    13501 ttatgcaagc tttgactacg aattgtcaga atatcgccca tctaagctgg tgaaaatgga
    13561 tatccttctc aatggagata aggtggatgc tctcagcttt atcgttcaca aggactttgc
    13621 ctacgaacgt gggaaactca tcgttgataa actcaagaaa atcatccctc gccaacaatt
    13681 tgaagttcca atccaagcgg ctattggaca caagattgtc gctcgtactg atatcaaggc
    13741 ccttcgtaag aacgtacttg ctaaatgtta tggtggtgac gtttctcgta agcgtaaact
    13801 ccttgaaaaa caaaaagctg gtaagaaacg catgaaatcc atcggatcag ttgaagttcc
    13861 gcaagaagcc ttcctcagcg tcttgagtat ggatgaagaa taagttatca gaaatgcctt
    13921 tccttgttca caggaaattt atataagaat caatagtaaa gcaggcttag atggtctgct
    13981 tttttagttt ttatactctt cgaaaatctc ttcaaaccac gtcatcgtcg ccttaccgta
    14041 tgtatggtta ctgacttcgt cagtttcatc tacaacctca aaaccatgtt ttgagctgac
    14101 ttcgtcagtt tcatctacaa cctcaaaacc atgttttgag ctgacttcgt cagtttcatc
    14161 tacaacctca aaaccatgtt ttgagctgac ttcgtcagtt tcatc
//
LOCUS       DAVLHC010000044        14101 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.045, whole genome shotgun sequence.
ACCESSION   DAVLHC010000044 DAVLHC010000000
VERSION     DAVLHC010000044.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 14101)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14101)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14101
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.045"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(77..274)
                     /locus_tag="VXE25_001650"
     CDS             complement(77..274)
                     /locus_tag="VXE25_001650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HEV0772081.1"
                     /translation="MTLNEYILQYRLKQAIDKMAESPNSPLSAISDQVGFSDYKYFAK
                     VFKKYLHISPKKLKSLGRIVK"
     gene            complement(349..1125)
                     /locus_tag="VXE25_001651"
     CDS             complement(349..1125)
                     /locus_tag="VXE25_001651"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000406168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycyl-radical enzyme activating protein"
                     /protein_id="HEV0772082.1"
                     /translation="MEISKGIIFNIQHFSIHDGPGIRTTVFLKGCPLRCPWCSNPESQ
                     RMKPEKMKDAQREKFTLVGEEKTVEEIITEVLKDKEFYEESGGGLTLSGGEIFAQFEF
                     AKAILKSAKEHHIHTAIETTAFVDHEKFIDLIQYVDFIYTDLKHYNSIKHKKVTGVFN
                     QMIIKNIHYAFSQNKTIVLRIPVIPNFNNSLEDAEKFATLFNSLNIDQVQLLPFHQFG
                     ENKYRLLNRKYEMDGVNALHPEDLIDYQKVFLNHHINCYF"
     gene            1247..1993
                     /locus_tag="VXE25_001652"
     CDS             1247..1993
                     /locus_tag="VXE25_001652"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000824973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HEV0772083.1"
                     /translation="MKRLEQIIKLVSEYEKIDVNTLSEKLNVSKVTIRKDLDKLESKG
                     LLHREHGYAVLNSGDDLNVRLSINYEIKRKIVQEAVKLVSDNETIMIESGSTCALLAE
                     EICKQKRNVTIVTNSFFIANFVRAYDSCRIIVLGGEFQKDSQVTVGPLLKEMIQTFHV
                     RQAFVGTDGYDKEMGFTGKDLMRSEVVQYISAASDKVIVLTDSSKFDKRGTVRRFALS
                     QVYEVITDEKLSKQNIATLENAGIMVKVVS"
     gene            2006..2986
                     /locus_tag="VXE25_001653"
     CDS             2006..2986
                     /locus_tag="VXE25_001653"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001070834.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar-binding transcriptional regulator"
                     /protein_id="HEV0772084.1"
                     /translation="MNQDRNKLLSKIAYLYYIENLNQSQIAAKLGIYRTSISRMLTEA
                     RNAGIVKIEIENFDTNMFKLENYVKEKYGLESLEIIPNEFDDNPTILSERISQVAAGV
                     LRNLIDDNMKIGFSWGKSLSNLVDLIHSKSVRNVHFYPLAGGPSHIHAKYHVNTLIYE
                     MSRKFHGECTFMNATIVQENKLLADGILQSRYFENLKNSWKDLDIAVVGIGDFSNKGK
                     HQWLDMLTEDDFKELTKVKTVGEICCRFFDSKGKEVYENLQERTIAISLEDLKNIPQS
                     LAVAYGDTKVSSILSVLRANLVNHLITDKNTILKVLEEDGDLTFREILGE"
     gene            3181..3501
                     /locus_tag="VXE25_001654"
     CDS             3181..3501
                     /locus_tag="VXE25_001654"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000402908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HEV0772085.1"
                     /translation="MEIIVPDQIIMGLILYAGDAKQHIYKALDYIKNGTCERCEEEIQ
                     LADAALLEAHNLQTKFLAQEASGTKTEITALFVHSQDHLMTSMTEINLIKEIISLRKE
                     LHKK"
     gene            3547..3855
                     /locus_tag="VXE25_001655"
     CDS             3547..3855
                     /locus_tag="VXE25_001655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000238716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEV0772086.1"
                     /translation="MVKIGLFCAAGFSTGMLVNNMKIAAQASGVEAEIEAFSQSKLAD
                     YAPNIDVALLGPQVAYTLDKSKEICDKCDVPIAVIPMMDYGMLDGKKVLDLALSLISG
                     "
     gene            3872..5170
                     /locus_tag="VXE25_001656"
     CDS             3872..5170
                     /locus_tag="VXE25_001656"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000041357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HEV0772087.1"
                     /translation="MAKMDVQKIIAPMMKFVNMRGIIALKDGMLAILPLTVVGSLFLI
                     MGQLPFEGLNKSIASVFGANWTEPFMQVYSGTFAIMGLISCFSIAYSYAKNSGVEALP
                     AGVLSVSAFFILLRSSYIPKQGEAIGDAISKVWFGGQGIIGAIIIGLVVGSIYTFFIK
                     RKIVIKMPEQVPQAIAKQFEAMIPAFVIFLLSMIVYILAKSLTNGGTFIEMIYSAIQV
                     PLQGLTGSWYGAIGIAFFISFLWWFGVHGQSVVNGVVTALLLSNLDANKAMLASGNLS
                     LENGAHIVTQQFLDSFLILSGSGITFGLVVAMLFAAKSKQYQALGKVAAFPAIFNVNE
                     PVVFGFPIVMNPVMFVPFILVPVLAAVIVYGAIATGFMQPFSGVTLPWSTPAILSGFL
                     VGGWQGVITQLVILAMSTLVYFPFFKVQDRLAYQNEIKQS"
     gene            5321..7759
                     /locus_tag="VXE25_001657"
     CDS             5321..7759
                     /locus_tag="VXE25_001657"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000248319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycyl radical protein"
                     /protein_id="HEV0772088.1"
                     /translation="MVNTEVARTTIKTEYFGSLTERMNKYREDVLNKKPYIDAERAVL
                     ATRAYERYKEQPNVLKRAYMLKEILENMTIYIEEESMIGGNQASSNKDAPIFPEYTLE
                     FVLNELDLFEKRDGDVFYITEETKEQLRSIAPFWENNNLRARAGALLPEEVSVYMETG
                     FFGMEGKMNSGDAHLAVNYQKLLQFGLRGFEERARKAKAALDLTDPASIDKYHFYDSI
                     FIVIDAIKVYAKRFVALAKSLAENANPKRKKELLEIADICSRVPYEPATTFAEAIQSV
                     WFIQCILQIESNGHSLSYGRFDQYMYPYMKADLESGKETEDSIVERLTNLWIKTITIN
                     KVRSQSHTFSSAGSPLYQNVTIGGQTRDKKDAVNPLSYLVLKSVAQTHLPQPNLTVRY
                     HAGLDARFMNECIEVMKLGFGMPAFNNDEIIIPSFIAKGVLEDDAYDYSAIGCVETAV
                     PGKWGYRCTGMSYMNFPKVLLITMNDGIDPASGKRFAPSFGHFKDMKNFSELENAWDK
                     TLRYLTRMSVIVENSIDLSLEREVPDILCSALTDDCIGRGKHLKEGGAVYDYISGLQV
                     GIANLSDSLAAIKKLVFEEERISPSQLWHALETDYAGEEGKVIQEMLIHDAPKYGNDD
                     DYADKLVTAAYDIYVDEIAKYPNTRYGRGPIGGIRYSGTSSISANVGQGRGTLATPDG
                     RNAGTPLAEGCSPSHNMDQHGPTSVLKSVSKLPTDEIVGGVLLNQKVNPQTLAKEEDK
                     LKLIALLRTFFNRLHGYHIQYNVVSRETLIDAQKHPEKHRDLIVRVAGYSAFFNVLSK
                     ATQDDIIGRTEHTL"
     gene            7778..8446
                     /locus_tag="VXE25_001658"
     CDS             7778..8446
                     /locus_tag="VXE25_001658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000395441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-6-phosphate aldolase"
                     /protein_id="HEV0772089.1"
                     /translation="MEFMLDTLNLDEIKKWSEILPLAGVTSNPTIAKREGSINFFERI
                     KDVRELIGSTPSIHVQVISQDFEGILKDAHKIRRQAGDDIFIKVPVTPAGLRAIKALK
                     KEGYHITATAIYTVIQGLLAIEAGADYLAPYYNRMENLNIDSNSVIRQLALAIDRQNS
                     PSKILAASFKNVAQVNNALAAGAHAVTAGADVFESAFAMPSIQKAVDDFSDDWFVIQN
                     SRSI"
     gene            8464..9552
                     /locus_tag="VXE25_001659"
     CDS             8464..9552
                     /locus_tag="VXE25_001659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol dehydrogenase"
                     /protein_id="HEV0772090.1"
                     /translation="MRIFASPSRYIQGENALFENAKSILDLGNYPILLCDQLVYDIVG
                     KRFEDYLHRYGFHIVLALFNGEASDNEINRVVALAEKENCDSIIGLGGGKTIDSAKAI
                     ADLIEKPVIIAPTIASTDAPVSALSVIYTDEGAFDHYLFYSKNPDLVLVDTKVISQAP
                     KRLLASGIADGLATWVEARAVMQANGKTMLGQQQTLAGVAIAKKCEETLFADGLQAMA
                     ACEAKVVTPALENIVEANTLLSGLGFESGGLAAAHAIHNGFTALTGDIHHLTHGEKVA
                     YGTLVQLLLENRPKEELDKYIEFYKKIGMPTTLKEMHLDQVGYDDLIKVGKQATMEGE
                     TIHQMPFKISPSDVAQAIIAVDAYVNSK"
     gene            10007..12508
                     /locus_tag="VXE25_001660"
     CDS             10007..12508
                     /locus_tag="VXE25_001660"
                     /EC_number="6.1.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014639013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="leucine--tRNA ligase"
                     /protein_id="HEV0772091.1"
                     /translation="MSFYNHKEIEPKWQGYWAEHHTFKTGTDASKPKFYALDMFPYPS
                     GAGLHVGHPEGYTATDILSRYKRAQGYNVLHPMGWDAFGLPAEQYAMDTGNDPAEFTS
                     ENIANFKRQINALGFSYDWDREVNTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVE
                     ELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLNDLDELDWSESIKD
                     MQRNWIGKSTGANVTFKVKGTDKEFTVFTTRPDTLFGATFTVLAPEHELVDAITSTEQ
                     AEAVADYKHQASLKSDLARTDLAKEKTGVWTGAYAINPVNGKEIPIWIADYVLASYGT
                     GAVMAVPAHDQRDWEFAKQFDLPIVEVLEGGNVEEAAYTEDGLHVNSDFLDGLNKEDA
                     IAKIVAWLEEKGCGQEKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLV
                     LPVTKDIRPSGTGESPLANLTDWLEVTREDGVKGRRETNTMPQWAGSSWYYLRYIDPH
                     NTEKLADEDLLKQWLPVDIYVGGAEHAVLHLLYARFWHKFLYDLGVVPTKEPFQKLFN
                     QGMILGTSYRDHRGALVATDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDV
                     VEQYGADTLRVYEMFMGPLDASIAWSEEGLEGSRKFLDRVYRLITSKEIVAENNGALD
                     KVYNETVKAVTEQIESLKFNTAIAQLMVFVNAANKEDKLYVDYAKGFVQLIAPFAPHL
                     AEELWQTVAATGESISYVAWPTWDESKLVEDEIEIVVQIKGKVRAKLMVAKDLSREEL
                     QEIALADEKVKVEIDGKEIVKVIAVPNKLVNIVVK"
     gene            12703..13398
                     /locus_tag="VXE25_001661"
     CDS             12703..13398
                     /locus_tag="VXE25_001661"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001144916.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0772092.1"
                     /translation="MPVNEYGQMIGESMEGYTPGALPSIDFLEGRYARIEALSVEKHA
                     EDLLAVYGPDTPREMWTYLFQESVADMEELVSLLNQMLARKDRFYYAIIDKATGKALG
                     TFSLMRIDQNNRVIEVGAVTFSPKLRGTRIGTEAQYLLARYVFEELNYRRYEWKCDSL
                     NLPSRRAAERLGFVYEGTFRQAVVYKGRTRDTDWLSMIDKDWPQVKARLEAWLTPENF
                     DKTGQQYKSLREL"
     gene            13410..13826
                     /locus_tag="VXE25_001662"
     CDS             13410..13826
                     /locus_tag="VXE25_001662"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0772093.1"
                     /translation="MITIKKQEIVKLEDVLHLYQAVGWTNYTHQPEMLEQALSHSLVI
                     YVALDGDAVVGLIRLVGDGFSSVFVQDLIVLPNYQRQGIGSLLMKEALKDYKDAYQVQ
                     LVTEETEKNVRFYRSMGFEALSTYDCIGMTWVNREK"
BASE COUNT         4537 a         2194 c         2948 g         4422 t
ORIGIN      
        1 tttcctgata gagatgttca catcttattt caattcacta tattagagta aaattctcta
       61 caaaaagaag aatagcctat ttgactattc ttccgagtga tttcaatttc tttggggaaa
      121 tatggagata ctttttaaat actttggcaa aatatttata gtctgaaaat ccaacttggt
      181 cagagatagc gcttaaaggg gagttgggag attcagccat cttatctata gcttgtttca
      241 ggcgatattg taagatatat tcatttagag tcatggggaa gtcttctttg ataaccttat
      301 atagatgctt gttatctgca aatagctaga gcatttcaag gaaatgaact agaaataaca
      361 attaatatgg tggttcagaa ataccttttg ataatcaata agatcttcag gatgaagtgc
      421 gttgactcca tccatttcat atttccgatt taataaacga tatttgtttt caccaaattg
      481 atgaaaaggg agtagttgaa cttggtcgat atttaatgag ttaaatagag tagcgaattt
      541 ttctgcatcc tctaaactat tgttaaaatt aggaataact gggattctta aaacgatagt
      601 tttattttga gaaaaagcat aatgaatgtt tttaataatc atttgattaa aaaccccagt
      661 cactttttta tgttttatag aattataatg ttttaggtct gtgtagataa aatccacata
      721 ttgaattaaa tcaataaatt tttcatgatc aacaaaggca gtagtttcaa tggcagtgtg
      781 tatgtgatgt tctttagctg attttaagat ggctttagca aattcaaact gagcaaatat
      841 ttcacctcct gataaagtta aacctccacc ggattcttcg taaaattctt tgtcttttaa
      901 tacctctgta ataatttctt ctacagtctt ttcttcaccg actaaggtga atttctctcg
      961 ttgagcatct ttcatttttt caggtttcat tctttgagat tcaggattag aacaccatgg
     1021 acagcgcaga ggacatcctt ttaaaaaaac agttgtacga atacccgggc cgtcatgaat
     1081 tgaaaagtgt tgaatattaa aaataattcc tttagatatt tccataagag ttcctcctct
     1141 tcataagtct atcctatcac aaaaacgaaa gaaaaacaat tacgaacgaa agtttaattt
     1201 gttgtttttt gctttttatt ttggtagaat aaaacggagg tgtaaaatga aaagattgga
     1261 acaaattatt aaattagtat cagaatatga aaagatcgac gttaatacat tatcggaaaa
     1321 attaaatgta tcgaaagtaa cgattagaaa agatttagat aaattagagt caaaaggttt
     1381 attacacaga gagcatggat atgctgtatt aaatagtgga gatgacttaa atgtacgttt
     1441 gtcaattaat tatgaaatta agagaaaaat tgttcaggaa gcagtaaaat tggtgtcaga
     1501 taatgaaaca ataatgatag aatctggatc gacctgtgct ttacttgctg aggaaatttg
     1561 caagcaaaaa agaaatgtta cgattgtaac aaattcattt tttatagcaa attttgtgag
     1621 agcttatgat tcatgtcgta ttattgttct tggtggagag tttcagaagg attcacaggt
     1681 tactgtggga cctttattaa aagaaatgat acagactttt catgtgcgtc aagcttttgt
     1741 tgggacagat ggctacgata aagagatggg ctttacagga aaagatttaa tgcgcagtga
     1801 ggtagttcaa tatatttcag cagcgtcgga taaagtcatt gtactaactg actcaagtaa
     1861 atttgataaa aggggtacag taagaagatt tgctttaagt caagtctatg aagtaataac
     1921 agacgaaaaa ctttctaaac aaaatatagc tacattagaa aatgctggga taatggttaa
     1981 ggtagtttcg taagaggtta agtgtatgaa tcaagatagg aataaactgc tttctaaaat
     2041 tgcttatctg tattatattg aaaacttaaa tcagtcacaa atagcagcaa aattaggaat
     2101 ttatagaacc tctattagta gaatgttaac agaagcaagg aatgcaggaa ttgttaaaat
     2161 tgaaatagag aattttgata caaatatgtt taagttggaa aattatgtaa aagaaaaata
     2221 tggtctggaa agtttagaaa ttattccaaa tgaatttgat gataatccaa caattttatc
     2281 tgaaagaatt tctcaagttg cagcaggtgt ccttaggaat ttaattgatg ataatatgaa
     2341 aattggcttt tcttggggga aaagtttaag taatttagta gatttaattc acagtaaaag
     2401 tgtccgaaat gttcacttct atcctctagc aggtggtcct agtcacatac acgctaaata
     2461 ccatgtgaat acactgattt atgaaatgtc tagaaaattt catggagagt gtacatttat
     2521 gaatgcaacg attgtgcaag aaaataaatt gttagcagat ggtattttgc aatcaagata
     2581 ttttgaaaat ttgaaaaata gttggaaaga tttagatata gctgtagtcg gaattggtga
     2641 ttttagcaat aaaggaaaac atcaatggtt agacatgctt acagaggatg actttaaaga
     2701 attgaccaaa gttaaaactg taggagaaat ttgttgtcga ttttttgatt caaaaggtaa
     2761 agaagtctat gaaaacttac aggaaagaac gatagcaatc tctttggaag atttaaaaaa
     2821 tattcctcaa agtttagctg ttgcttacgg tgatacgaaa gtatcttcga ttctttctgt
     2881 cttgcgtgct aatttagtaa atcatttgat tacagacaaa aatacaattt taaaagtttt
     2941 ggaagaagat ggggatttga cttttagaga gattctaggt gagtgaaaat gatagactga
     3001 tcagtttatc gttttttctt tttagtcgat tgcacatttg tgctcatata aacaaaaata
     3061 gtttatctgt tgtttttgga ttgacaactt tattatgtag ttgtattcta tagttacaaa
     3121 agaaaatttt aaaatttcaa atgaaaaaag ctttttacat agtgaaatga ggaggaattt
     3181 atggaaatta ttgttccaga tcaaattatc atgggtttaa ttttatatgc tggtgatgcg
     3241 aaacaacata tttataaagc gttagattac ataaaaaatg gtacatgtga acggtgtgaa
     3301 gaagaaatcc agttagctga tgccgcctta ttagaagccc ataatctaca aacaaaattc
     3361 ttggcacaag aagcgtctgg tacaaagaca gaaattacag ctctctttgt tcattcacaa
     3421 gatcatctca tgactagtat gacggagatt aatttaatca aagaaattat tagtttgaga
     3481 aaagaacttc ataaaaaata atactagagt attatcattg ttattaacat agaggaggaa
     3541 aacataatgg tgaagattgg tttgttttgt gcagcaggtt tttctactgg tatgcttgta
     3601 aataatatga aaattgcagc gcaagctagt ggagttgagg cagaaataga ggcgttttct
     3661 cagtctaaat tagcggatta tgcgccaaat atagatgttg cactattggg tccacaagtt
     3721 gcttatacat tagataaatc aaaagaaatt tgtgataagt gtgatgttcc gatagctgtt
     3781 attccgatga tggactatgg tatgttagat ggaaaaaaag tattagattt ggccctatct
     3841 ttgattagtg ggtaagaaaa ggagatttat tatggcaaag atggatgttc agaaaatcat
     3901 tgcaccgatg atgaagtttg tgaatatgcg tggcattata gctctaaaag atgggatgtt
     3961 agcaattttg ccattgacag tagttggtag tttattcttg attatgggac aattgccgtt
     4021 cgaaggatta aataagagca ttgctagtgt ttttggagct aattggacag agccgtttat
     4081 gcaagtatat tcaggaactt ttgctattat gggtctaatt tcttgttttt caattgccta
     4141 ttcttatgct aagaatagcg gagtagaggc tttaccagct ggagttctat ctgtatctgc
     4201 attctttatt ttgctaagat catcttatat ccctaaacaa ggtgaggcaa ttggggatgc
     4261 tattagtaaa gtttggtttg gaggtcaagg aattatcggt gctatcatta taggtttggt
     4321 agtaggaagt atttatacct tctttataaa gagaaaaatt gttattaaga tgccagaaca
     4381 agttccacaa gctattgcca aacagtttga agcaatgatt ccagcatttg taattttctt
     4441 actttctatg attgtatata ttttagcgaa gtcattgact aatggcggaa cattcataga
     4501 aatgatttat tctgctattc aagttccatt gcaaggttta actggatctt ggtatggtgc
     4561 aattggaatt gcattcttta tatcattttt gtggtggttt ggtgttcatg gacaatcggt
     4621 agtaaatgga gtagtgacag ctctgctttt atctaatctt gatgctaata aagctatgtt
     4681 agcctctggt aatctatcat tagaaaatgg tgcacatatt gttactcaac aatttttaga
     4741 ttcattttta attctatcag gttcagggat tacgtttggt cttgtagttg ccatgctttt
     4801 tgcagcaaaa tcaaaacaat accaagcctt aggaaaagtt gccgcttttc cagcaatatt
     4861 taacgtaaat gagccagttg tatttggatt tccgattgtc atgaatccag ttatgtttgt
     4921 acctttcatt cttgttcctg tacttgcagc tgtgatagta tatggagcta ttgcaacagg
     4981 tttcatgcag ccattctcag gggtaacatt gccttggagt acaccagcta ttttatcagg
     5041 atttttggtg ggtggatggc aaggagttat tactcagctg gtgatattag cgatgtctac
     5101 attggtttat tttccattct ttaaagtaca ggatcgttta gcttaccaaa atgaaatcaa
     5161 acaatcttag aggtatttgt gtgttactgt taaactcaca catttgtgct aaaaattaga
     5221 gagttaaaat ttttctagtt aaaagcttga aaatttctat aaaaatcggt attatatttt
     5281 cgaaagaaat aaaaatattt tcgaaagaaa ggtggttacg atggtaaata cagaagtagc
     5341 aagaacaaca atcaagacag aatattttgg cagccttact gaaaggatga acaaatatcg
     5401 agaagatgtt ttaaataaaa aaccttatat tgatgctgag agagcagttc tagcaacacg
     5461 cgcctatgaa cgatacaagg aacaacctaa tgtcctaaaa cgtgcatata tgctgaaaga
     5521 aattttggaa aatatgacta tctatattga agaagaatct atgattgggg gaaatcaagc
     5581 ttcttccaat aaagatgctc ctatttttcc ggaatatacg ctagaatttg ttctcaatga
     5641 gttggatctt tttgaaaagc gtgatggaga tgttttctat attacagaag aaacaaaaga
     5701 acaacttaga agtattgctc cgttttggga aaataataat ttacgtgcta gagctggtgc
     5761 cttattacct gaagaagtgt ctgtttatat ggaaacagga ttcttcggta tggaaggtaa
     5821 gatgaattct ggagatgctc acctagcagt taactatcag aaacttttgc aatttggctt
     5881 aagaggtttt gaagagcggg ctcgtaaagc aaaagcagct ctagatttaa cagatccagc
     5941 aagtattgat aaatatcatt tttacgactc tatatttatc gtaatcgatg ctattaaagt
     6001 atatgcaaag cgctttgttg ctcttgctaa aagtttagcc gaaaatgcaa atcctaaacg
     6061 taagaaagaa ttacttgaga ttgcagatat ttgctctaga gtcccatatg aaccggcaac
     6121 tacttttgca gaagctattc aatcagtttg gtttattcaa tgtattttac aaattgaatc
     6181 taatggccac tctctttcat atggccgttt tgatcaatat atgtatccat atatgaaggc
     6241 tgatttagaa agtggtaaag aaacagaaga tagcattgtt gaacgtctga caaatctttg
     6301 gattaagaca attacaatta ataaggttcg cagtcaatca catacatttt cttcagcagg
     6361 aagtccttta tatcaaaatg ttacaattgg tggacagact cgagataaga aggatgctgt
     6421 taacccatta tcttatttgg tattaaaatc agttgcacaa acccatctac cgcaacctaa
     6481 tctaactgta cgttaccatg caggtttaga tgctcgtttc atgaatgagt gtattgaagt
     6541 gatgaaactt ggttttggta tgcctgcatt taataatgat gagattatta ttccttcttt
     6601 tattgcaaaa ggagtattgg aagatgatgc ttatgattac agtgccattg gatgtgttga
     6661 aacggcagtt ccagggaaat ggggctatcg ttgcacaggt atgagttata tgaacttccc
     6721 taaggttcta cttatcacga tgaatgatgg aattgatccg gcttcgggta aacggtttgc
     6781 accaagcttt ggtcatttta aggatatgaa gaacttttct gaattagaaa atgcttggga
     6841 taaaacacta agatatttga cacgaatgag tgttattgtt gaaaattcta ttgatttatc
     6901 attggaacga gaagttcctg atattctatg ttcagcattg actgatgatt gtattggtcg
     6961 tggaaaacac cttaaagaag gtggagcagt atatgattat atatcaggat tgcaagttgg
     7021 aattgcaaat ttgtcggatt cattagctgc aattaaaaaa ttggtgtttg aggaagaacg
     7081 tataagccca agtcagcttt ggcatgcact ggaaacagat tatgccggag aagaaggtaa
     7141 ggtcattcaa gaaatgttga ttcatgatgc acctaagtat ggtaatgatg atgattatgc
     7201 tgacaaattg gttactgctg cttatgacat ttatgttgat gaaattgcta aatatcctaa
     7261 tacacgttat ggaagaggtc caattggagg aattcgttat tcaggaacat cttctatctc
     7321 agccaacgta gggcagggac gtggaacatt agcaactcca gatggacgca acgcgggtac
     7381 accgttagca gagggttgtt caccatcaca taatatggat caacacggcc ctacatctgt
     7441 tttaaaatct gtttcaaaat taccaacaga tgaaatcgta ggtggggttc tcttaaatca
     7501 gaaagtaaat cctcaaacgt tagccaaaga agaagataaa ttaaaactaa ttgctttgtt
     7561 acgaacattc tttaatcgtt tacatgggta ccatattcaa tacaatgttg tttccagaga
     7621 gacgctgatt gacgctcaga aacatcctga aaaacacaga gacttaattg ttcgtgttgc
     7681 aggatactct gcattcttca atgttctttc taaggcaacc caagatgaca ttataggacg
     7741 tactgagcat actttgtaaa ataaagaggt tctttttatg gaatttatgc ttgacacatt
     7801 aaatttagat gagattaaaa agtggtctga aattttgccg ctagctgggg taacttcaaa
     7861 tcccactatt gcaaaaagag agggttctat taattttttt gaacgaatca aagatgtaag
     7921 agaattgatt ggctctacac cctctattca tgttcaggtg atttctcaag attttgaagg
     7981 catcttaaag gatgctcata aaattcgaag acaagcagga gatgatatat ttatcaaagt
     8041 acctgttact ccagctggat tacgtgcaat aaaggcgcta aaaaaagagg gctaccatat
     8101 cactgcaaca gctatttata cagttattca gggattatta gctatcgaag caggagcgga
     8161 ttacctagct ccatattata atagaatgga aaatctgaac attgattcaa attctgtcat
     8221 tcgtcaatta gctcttgcta ttgatagaca gaactctcct agtaagattt tagctgcatc
     8281 ctttaaaaat gtagcacaag taaataatgc tttagctgca ggtgcgcatg ctgttacagc
     8341 aggagcggat gtttttgaat cagctttcgc catgccatct atccaaaagg cggttgatga
     8401 tttttctgac gattggtttg ttattcaaaa tagtcgttcc atttagatag agaggaaata
     8461 catatgagaa tttttgctag tccttctaga tatattcagg gggaaaatgc cttgtttgaa
     8521 aatgccaaat caattttgga tttgggaaat taccctattc tattatgcga tcagttggtt
     8581 tatgatattg ttggaaaacg atttgaagat tacctacata ggtatggttt ccatattgtt
     8641 ctggcgctat ttaatggtga agcttctgac aatgaaatca atcgagttgt tgccttggct
     8701 gagaaagaaa attgtgatag tattatcggt cttggtgggg gaaagacgat tgatagcgca
     8761 aaagctattg cagatttgat tgaaaagcct gttattattg ctccaacaat tgcatcgacc
     8821 gacgcacctg tatctgcttt atctgttatt tatacagatg aaggtgcatt tgatcattat
     8881 ctattttatt ctaaaaatcc agatttagtt ttggttgata caaaagttat ttcacaagcc
     8941 cctaagcgtt tattagcgtc tggtattgca gatggtttag caacttgggt tgaggcgcgt
     9001 gcggttatgc aggcaaatgg aaaaactatg ttgggacaac agcaaacatt ggctggagtt
     9061 gcaattgcga agaaatgtga agaaacgctg tttgcagatg gtttacaggc tatggcagct
     9121 tgtgaagcta aagtggtgac accagcatta gaaaatattg ttgaagctaa tactttattg
     9181 agtggtctag gttttgaaag tggaggatta gctgcggcgc atgcaattca taatggtttt
     9241 actgcattga caggtgacat tcatcattta acacatggtg aaaaagtagc ttatggaact
     9301 ttagtacaac tattattgga aaatagacct aaagaagaac ttgataagta tattgagttt
     9361 tacaaaaaaa ttggtatgcc aacaactcta aaagaaatgc atttggatca agttggatat
     9421 gatgatttaa taaaagttgg taaacaagca actatggagg gtgagacaat tcatcagatg
     9481 ccgtttaaga tttcgccttc agatgttgct caagctatta tcgctgtaga tgcctatgta
     9541 aattcaaaat aaacaataag gactactgtt ttccaaatgg tagtctttta ttgatccctg
     9601 tattgaattc tatagcagat tgaaatagga tgagaacaaa tcgattggga aagtaaaatt
     9661 aatttctata aatgttttag caattgtttc gtactatttc agattcagtc cactatacgt
     9721 tcttcataaa tcaaaaagcg acataggttg tcggctattt attgtgaata cattaattag
     9781 cattccagtt ttatcttcgg tctaaaataa gtattttgtg ctatacgaga taagcttctt
     9841 gacttactcc ttgatttact gcataacaat gggataaaaa gtgggagata gagcaattca
     9901 tagtcatcaa aattaatgag atacagtata cagttttttc tttaaacaca tttcaaattc
     9961 cctcaaaaat ggtataatag taacatcaca aaattggaga gagaccatga gtttttacaa
    10021 tcataaagaa attgaaccta agtggcaggg ctactgggca gaacatcata catttaagac
    10081 aggaacagat gcatcaaaac ctaagtttta tgcgcttgat atgttccctt atccgtctgg
    10141 agctggtctg catgtaggac acccagaagg ttatactgca accgatatcc tcagtcgtta
    10201 caaacgtgcg caaggctaca atgtccttca cccaatgggt tgggatgctt ttggtttacc
    10261 tgcagagcaa tacgctatgg atactggtaa tgacccagca gaatttacat cggaaaacat
    10321 tgccaacttc aaacgtcaaa tcaatgcgct tggattttct tatgactggg atcgtgaagt
    10381 caacacaaca gatccaaact actacaagtg gactcaatgg attttcacca agctttacga
    10441 aaaaggcttg gcctatgaag ctgaagtgcc agtaaactgg gttgaggaat tgggaactgc
    10501 cattgccaat gaagaagtgc ttcctgacgg aacttctgaa cgtggaggct atccagttgt
    10561 ccgcaaacca atgcgccaat ggatgctcaa aatcacggct tacgcagagc gcttgctcaa
    10621 tgacttagat gaactagatt ggtcagagtc tatcaaggat atgcaacgca actggattgg
    10681 taaatcaact ggtgccaatg taactttcaa agtaaaagga acagacaagg aatttacagt
    10741 ctttactact cgtccggaca cacttttcgg tgcgactttc actgttttgg ctcctgaaca
    10801 tgaattagta gatgccatca caagcacaga gcaagcagaa gcagtagcag actacaaaca
    10861 ccaagccagc cttaagtcag acttggctcg taccgacctt gccaaagaaa aaactggtgt
    10921 atggactggt gcttatgcca tcaatcctgt caatggtaag gaaattccaa tctggattgc
    10981 ggattacgtt cttgctagct atggtacagg tgcggtaatg gctgtgcctg cccacgatca
    11041 acgtgactgg gaatttgcca aacaatttga ccttccaatc gtcgaagtac ttgaaggtgg
    11101 aaatgttgaa gaagctgcct acacagaaga tggccttcac gttaattcag acttcctaga
    11161 tggactcaac aaagaagacg ctattgccaa gattgtggct tggttggaag aaaaaggctg
    11221 tggacaagag aaggtaacct accgtctccg cgactggctc tttagccgtc aacgttactg
    11281 gggtgagcca atcccaatca ttcattggga agatggaact tcaacagctg tccctgaaag
    11341 tgaattgcca cttgtcttgc ctgtaaccaa ggatatccgt ccctcaggta ctggtgaaag
    11401 tccactagct aacttgacag actggcttga agtgactcgt gaagatggtg tcaaaggtcg
    11461 tcgtgaaaca aatactatgc cacaatgggc aggttcaagc tggtactacc tccgctatat
    11521 tgacccacac aatactgaga aattggctga cgaggatctg ctcaaacaat ggttgccagt
    11581 agatatctac gtgggtggtg cggaacatgc tgtacttcac ttgctttacg ctcgtttctg
    11641 gcataaattc ctctatgacc tcggtgttgt tccaactaag gaaccattcc aaaaactctt
    11701 taaccaagga atgattttgg gaacaagcta tcgtgaccac cgtggggctc ttgtggcgac
    11761 tgacaaggtt gaaaaacgtg atggttcttt cttccatgtg gaaacagggg aagagttgga
    11821 gcaagcgcca gccaagatgt ctaaatcgct caagaacgtt gttaacccag acgatgtggt
    11881 ggaacaatac ggtgccgaca ctcttcgtgt ttatgaaatg tttatgggac cacttgatgc
    11941 ttcgattgct tggtcagaag aaggtctaga aggaagccgt aaattccttg accgtgttta
    12001 ccgtttgatt acaagcaagg aaattgttgc ggaaaacaat ggcgctctcg acaaagttta
    12061 caacgaaacc gttaaagctg tcacagaaca aattgagtcc ctcaaattca acacagccat
    12121 tgctcaactt atggtctttg tcaacgctgc caacaaggaa gacaaacttt atgtagacta
    12181 cgccaaaggc ttcgttcagt tgattgctcc atttgctcct cacttggcag aagagctctg
    12241 gcaaacagtt gcagcaacag gagaatctat ctcttatgta gcttggccaa cttgggatga
    12301 aagcaaatta gttgaagacg aaatcgaaat cgtcgtccaa atcaaaggta aagtccgtgc
    12361 caaactcatg gttgctaaag acctgtcacg cgaagaattg caagaaattg ctctcgctga
    12421 tgaaaaagtc aaggtagaaa ttgacggtaa ggaaatcgtg aaagtgattg cggtacctaa
    12481 caaactcgtt aatatcgtcg ttaaataacg agtttattag ctctatctgc caccttcaat
    12541 agtccactgg actattgaag ccaactaaat tggttaatat tgttgtgaaa taagatagga
    12601 atccttcaga gtagaatctg ggggattttt tgaatcttct tatgaaagta tgttatacta
    12661 tggtcaacta taaaatttga aaagcgaaac aaggggaaag ttatgccagt aaatgaatat
    12721 ggtcagatga ttggtgagtc aatggaaggt tatacacctg gtgcactgcc ttctattgat
    12781 ttcttagaag ggcgttatgc tcgaatagaa gctctttcag tggaaaagca tgcggaggat
    12841 ttattagctg tttatggccc tgatacgcct cgggaaatgt ggacctacct ctttcaggaa
    12901 tcagtggcag atatggagga gctggttagc cttttaaatc agatgttggc tcgtaaggac
    12961 cgtttttact atgcaatcat agacaaggca actggtaagg ctttgggaac tttttctctc
    13021 atgcgtattg accagaataa tcgagtaata gaagtgggag ctgtcacttt ttctccaaaa
    13081 ctcaggggga cacggatagg gacagaagcc cagtatctac tggcgcgcta tgtctttgaa
    13141 gagcttaact atcgtcgcta tgagtggaaa tgtgattctc ttaatctgcc atccagacga
    13201 gcagcggaac gtttgggatt tgtctatgaa ggaaccttcc gtcaggcagt ggtttataag
    13261 gggcgtacga gggatacgga ttggttgtct atgattgata aggactggcc tcaagtcaaa
    13321 gctcgattgg aagcatggct gactcctgaa aattttgata aaactgggca acaatacaag
    13381 agtttgagag aactttaaga ggtgttgaga tgattactat taaaaagcaa gaaattgtca
    13441 agctagagga tgttttgcat ctctatcagg ctgtcggttg gacaaattat acccatcaac
    13501 cagagatgct ggagcaggcc ttatctcatt cattagtgat ttatgtggcg cttgatggtg
    13561 atgctgtagt gggcttgatt cgtttggttg gagatggttt ttcatcagtt tttgtacagg
    13621 atttgattgt tttgcctaac tatcagcgcc aagggattgg tagtctcttg atgaaagagg
    13681 ctttaaaaga ttacaaagat gcctatcaag tccagctggt gacagaagag acagaaaaaa
    13741 acgtaagatt ttatcgttct atgggttttg aagccttatc cacctatgat tgtataggaa
    13801 tgacttgggt gaatcgagaa aaataacaaa acttgttttt tcttaagcaa agtttaagga
    13861 tggtctagta tcatatagtc attaaataaa gacctcctaa ctttatttaa taaaatccta
    13921 aacttttttc atcacaatct cctaatgaag ccacccaatc aggtggcttt tttgcgtggt
    13981 gaggtgctgg tgatagaaat tttttgcaaa atagtaaaat tttagaaaag ttaagctagt
    14041 tttaagtttc gtcttgtatc atgtagttat taaataaaga cctcctaact ttatttaata
    14101 a
//
LOCUS       DAVLHC010000045        13499 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.046, whole genome shotgun sequence.
ACCESSION   DAVLHC010000045 DAVLHC010000000
VERSION     DAVLHC010000045.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 13499)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13499)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13499
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.046"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(164..904)
                     /locus_tag="VXE25_001663"
     CDS             complement(164..904)
                     /locus_tag="VXE25_001663"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001823113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HEV0772094.1"
                     /translation="MATYETFAAVYDAVMDDSLYDKWTNFSLRHLPKTKERKKLLELA
                     CGTGIQSVRFSQAGFDVTGLDLSADMLKIAEKRATSAKQKIAFIEGNMLNLSKAGKYD
                     FVTCYSDSICYMQDEVEVGDVFKDVYNALNEEGVFIFDVHSTYQTDEVFPGYSYHENA
                     EDFAMLWDTYEDETPHSIVHELTFFIKEADGSFSRHDEVHEERTYEILTYDILLEQAG
                     FKSFKLYADFEDKEPTETSTRWFFVAQK"
     gene            complement(1224..1577)
                     /gene="rsfS"
                     /locus_tag="VXE25_001664"
     CDS             complement(1224..1577)
                     /gene="rsfS"
                     /locus_tag="VXE25_001664"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001003018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome silencing factor"
                     /protein_id="HEV0772095.1"
                     /translation="MNEKELLELVVKAADEKRAEDILALDVQDLTSVTDYFVITSSMN
                     SRQLDAIAANIREKVAQAGFKGSHVEGDAAGGWVLLDLGAVVVHIFSEEMRAHYNLEK
                     LWHEANSVDISEALA"
     gene            complement(1590..2090)
                     /locus_tag="VXE25_001665"
     CDS             complement(1590..2090)
                     /locus_tag="VXE25_001665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000844697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine hydrolase"
                     /protein_id="HEV0772096.1"
                     /translation="MKTAFIIIDVQNVLVETGFQTKSLLEKISYLQNQARSKNIEIIY
                     VQHIENSEAQTSEDWQLSALLNRKPAEKVFQKKYNSIFKETGLKEYLDKQGIEKLVLC
                     GMQTEYCVDTSVKVAFEYGYQLIVPEGAVTTFDGDDIPAETINEFYEDIWEERFADVL
                     DYKHIF"
     gene            complement(2091..2684)
                     /gene="yqeK"
                     /locus_tag="VXE25_001666"
     CDS             complement(2091..2684)
                     /gene="yqeK"
                     /locus_tag="VXE25_001666"
                     /EC_number="3.6.1.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /protein_id="HEV0772097.1"
                     /translation="MSYQDYINCSREALLEKMAELLPEKRLTHCLGVERAAMELAQRF
                     GVDVEKASLAGLLHDYAKKLSDQEFLALIDRYQLDPDLKNWGNNVWHGMVGIYKIQED
                     LDLHDSEILRAIEIHTVGAGQMTDLDKVIYVADYIEHNRAFPGVDVAREIASLSLNKA
                     VAYETARTVEYLAHQGFPIYPQTLETYNAFVHYLKED"
     gene            complement(2684..3313)
                     /locus_tag="VXE25_001667"
     CDS             complement(2684..3313)
                     /locus_tag="VXE25_001667"
                     /EC_number="2.7.7.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000151307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinate-nucleotide adenylyltransferase"
                     /protein_id="HEV0772098.1"
                     /translation="MTIELLTPFTKVELEPEIKEKKRKQVGILGGNFNPVHNAHLIVA
                     DQVRQQLGLDQVLLMPEYQPPHVDKKETIPEHHRLKMLELAIEGIDGLVIETIELERK
                     GISYTYDTMKILTEKNPDTDYYFIIGADMVDYLPKWYRIDELVDMVQFVGVQRPRYKV
                     GTSYPVIWVDVPLMDISSSMVRDFLAQGRKPNFLLPQPVLDYIEKEGLY"
     gene            complement(3365..3675)
                     /gene="yhbY"
                     /locus_tag="VXE25_001668"
                     /pseudo
     CDS             complement(3365..3675)
                     /gene="yhbY"
                     /locus_tag="VXE25_001668"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000060164.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome assembly RNA-binding protein YhbY"
     gene            complement(3890..4996)
                     /gene="yqeH"
                     /locus_tag="VXE25_001669"
     CDS             complement(3890..4996)
                     /gene="yqeH"
                     /locus_tag="VXE25_001669"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000391231.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase YqeH"
                     /protein_id="HEV0772099.1"
                     /translation="MEEILCIGCGATIQTTDKAGLGFTPQSALEKGLETGEVYCQRCF
                     RLRHYNEITDVQLTNDDFLKLLHEVGDSDALVVNVIDIFDFNGSVIPGLPRFVSGNDV
                     LLVGNKKDILPKSVKSGKISQWLMKRAHEEGLRPVDVVLTSAQNKHAIKEVIDKIEHY
                     RKGRDVYVVGVTNVGKSTLINAIIQEITGDQNVITTSRFPGTTLDKIEIPLDDGSYIY
                     DTPGIIHRHQMAHYLTAKNLKYVSPKKEIKPKTYQLNPEQTLFLGGLGRFDFIAGEKQ
                     GFTAFFDNELKLHRSKLEGASAFYDKHLGTLLTPPNSKEKEDFPRLVQHVFTIKDKTD
                     LVISGLGWIRVTGIAKVAVWAPEGVAVVTRKAII"
     gene            complement(4999..5589)
                     /locus_tag="VXE25_001670"
     CDS             complement(4999..5589)
                     /locus_tag="VXE25_001670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YqeG family HAD IIIA-type phosphatase"
                     /protein_id="HEV0772100.1"
                     /translation="MDCFILVTKENCEKKLRKGARMAIENYIPDFAVEAVYDLTVPSL
                     QAQGIKAVLVDLDNTLIAWNNPDGTPEMKQWLHDLRDAGIGIIVVSNNTKKRVQRAVE
                     KFGIDYVYWALKPFTFGIDRAMKEFHYDKKEVVMVGDQLMTDIRAAHRAGIRSILVKP
                     LVQHDSIKTQINRTRERRVMRKITEKYGPITYKKGI"
     gene            complement(5541..6449)
                     /locus_tag="VXE25_001671"
     CDS             complement(5541..6449)
                     /locus_tag="VXE25_001671"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="magnesium transporter CorA family protein"
                     /protein_id="HEV0772101.1"
                     /translation="MVLEKQLGNGCTWIDLDLGKLNKLEDLSEIYGLDKETIEYALDR
                     NERAHMDYHRESGTVTFIYNVLDVKKDKAYYETFPMTFIVEHRRLITISNTKNAYVIE
                     QMTRYLESHDTLSIYKFLFASLEIISNAYYPVIEQMDKSRDEVNDLLRQRTTKKNLFA
                     LSDLETGMVYLTAAAKQNRILLEHIQGHALYRSFDEIEREQFDDAMIEAHQLVSMTDL
                     ISQILQQLSASYNNILNNNLNDNLTTLTIISVLLAVLAVVTGFFGMNVPLPLTDEPHA
                     WLYISLASAGLWIVLSLLLRKIAKKS"
     gene            complement(6506..7066)
                     /locus_tag="VXE25_001672"
     CDS             complement(6506..7066)
                     /locus_tag="VXE25_001672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mechanosensitive ion channel"
                     /protein_id="HEV0772102.1"
                     /translation="MQKFIQAYIEKLDVTTIIENILTKVISLLLLLIVFYIAKKMLHT
                     MVQRIVKPSLKMSRHDVGRQKTISRLLENVFNYTLYFFLLYCILSILGLPVSSLLAGA
                     GIAGVAIGMGAQGFLSDVINGFFILFERQLDVGDEVVLTNGPITVSGKVVSVGIRTTQ
                     LRSEEQALHFVPNRNITVVSNFSRTD"
     gene            7205..8413
                     /gene="sstT"
                     /locus_tag="VXE25_001673"
                     /pseudo
     CDS             7205..8413
                     /gene="sstT"
                     /locus_tag="VXE25_001673"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000713440.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="serine/threonine transporter SstT"
     gene            8481..9434
                     /locus_tag="VXE25_001674"
     CDS             8481..9434
                     /locus_tag="VXE25_001674"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000028179.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aromatic acid exporter family protein"
                     /protein_id="HEV0772103.1"
                     /translation="MSISQRTTKLILATCLACLLAYFLNLSSAVSAGIIALLSLSDTR
                     RSTLKLARNRLFSMLLALAIGVLAFHLSGFHIWSLGLYLAFYVPLAYKMGWEIGITPS
                     TVLVSHLLVQESTSPDLLVNEFLLFAIGTGFALLVNLYMPSREEEIQHYHTLVEEKLK
                     DILQRFKYYLSRGDGRNRAQLVAELDTLLKEALRLVYLDHSDHLFHQTDYHIHYFEMR
                     QRQSRILRNMAQQINTCHLAASESLILAQLFSKIAGQLSQTNPASDLLDEIERYLEVF
                     RNRSLPKTREEFETRATLLQLLREAKTFIQVKVDFYQKYRQ"
     gene            9577..9957
                     /locus_tag="VXE25_001675"
     CDS             9577..9957
                     /locus_tag="VXE25_001675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000221621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HEV0772104.1"
                     /translation="MTYLEKWFDFNRRQKEIESLLEETIAQQSEQSLTLKEFYLLYYL
                     DLAEEKSLRQIDLPDKLHLSPSAVSRMVARLEAKNCGLLSRMCCHQDRRSSFICLTND
                     GQKTLASLQKTVEESLEAGLDFLI"
     gene            10057..10278
                     /locus_tag="VXE25_001676"
     CDS             10057..10278
                     /locus_tag="VXE25_001676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4649 family protein"
                     /protein_id="HEV0772105.1"
                     /translation="MIEITYIDASKNERTVTFESYEDFERSQQACLIGVADYYPVQKL
                     TYKGHNLDYHGTYGDIFFYLMKQDLSQYN"
     gene            10295..10609
                     /gene="trxA"
                     /locus_tag="VXE25_001677"
     CDS             10295..10609
                     /gene="trxA"
                     /locus_tag="VXE25_001677"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003004519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="HEV0772106.1"
                     /translation="MAKAITDATFEQETKDGLVLVDFWATWCGPCRMQGPILDKLSEE
                     LSEDVLKIVKMDVDENPNTARAFGIMSIPTLLFKKDGQVVKQVAGVHTAEQIKAIIAE
                     LS"
     gene            10914..11447
                     /gene="queF"
                     /locus_tag="VXE25_001678"
     CDS             10914..11447
                     /gene="queF"
                     /locus_tag="VXE25_001678"
                     /EC_number="1.7.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000828792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADPH-dependent 7-cyano-7-deazaguanine reductase
                     QueF"
                     /protein_id="HEV0772107.1"
                     /translation="MKRQSALVVFSGGQDSTTCLFWVMQHYETVEAVTFAYGQRHHLE
                     IQIAREIAKEQGIRHHILDMSLLGQITAQPDFATIHISYIPDKLCVESKSLKLYLFSY
                     RNHGDFHENCINTIGKDLVNLLDPRYLEVWGKFTPRGGISIDPYYNYGKQGTKYEDLA
                     EQRLFQHDLYPEKIDNR"
     gene            11497..11766
                     /locus_tag="VXE25_001679"
     CDS             11497..11766
                     /locus_tag="VXE25_001679"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772108.1"
                     /translation="MLKAVFEVIDKTDEVSSKHCFEVADRTDEVSLKHCFEVVDRTDE
                     VSLKHCFEVADRTDVVSNHTYGKVKLTWFEEIFEEYHTKKPCSSR"
     gene            complement(11791..12459)
                     /locus_tag="VXE25_001680"
     CDS             complement(11791..12459)
                     /locus_tag="VXE25_001680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000714831.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aquaporin"
                     /protein_id="HEV0772109.1"
                     /translation="MKKFVAELIGTFMLVFVGTGAVVFGNGLDGLGHLGIAFAFGLAI
                     VVAAYSIGTVSGAHLNPAVSIAMFVNKRLSSSELVNYILGQVVGAFIASGAVFFLLAN
                     SGMSTASLGENALANGVTVFGGFLFEVIATFLFVLVIMTVTSESKGNGAIAGLVIGLS
                     LMAMILVGLKITGLSVNPARSLAPAVLVGGAALQQVWIFILAPIAGGVLAALVAKNFL
                     GTEK"
     gene            complement(12570..13361)
                     /locus_tag="VXE25_001681"
                     /pseudo
     CDS             complement(12570..13361)
                     /locus_tag="VXE25_001681"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399297.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2785 domain-containing protein"
BASE COUNT         3898 a         3011 c         2589 g         4001 t
ORIGIN      
        1 taactcttct tctgttttaa actgtaagtc gttataaatt tgctttaact tttgataaat
       61 tttaggtata ttggtaatta cttctttttc aagaatatca ccaaatggta ttggtatatt
      121 cattttccct tacctcctaa gcataagatt aacaatattt gatttacttc tgcgccacaa
      181 aaaaccaacg ggtgctagtt tctgttggct ccttatcctc aaagtctgca tagagtttga
      241 aggacttaaa tccagcctgt tccagcaaga tatcataggt caagatctca taggtcctct
      301 cctcatgtac ttcatcgtgg cgactaaagg aaccgtcagc ctccttgata aagaaagtca
      361 gctcatgcac gatggagtga ggagtttcgt cctcatatgt atcccaaagc atggcaaaat
      421 cttccgcatt ttcatggtag gaatagccag ggaatacttc atctgtctgg taggtcgagt
      481 gcacgtcaaa gatgaaaact ccctcttcat tcagcgcatt gtacacgtcc ttaaagacgt
      541 cccctacttc cacctcatcc tgcatatagc agatagagtc cgaataacac gtgacaaaat
      601 cgtatttccc tgccttggac aaattcagca tattaccttc tataaaagca atcttttgct
      661 tggctgaagt tgctctcttc tccgcaatct tcaacatatc cgcactcaag tcaagtccag
      721 tcacatcaaa accagcctga gagaagcgca ctgattgaat tcctgtccca caagccagtt
      781 ccaagagttt ctttctctcc ttggtcttag gcaaatgacg cagagaaaaa ttcgtccatt
      841 tgtcgtataa actatcgtcc atgaccgcat catagacagc cgcaaaggtt tcataagtcg
      901 ccataaaaca tgataccaag tccgcccgta attcgataga aaattaggag ccttacgatg
      961 gagccgagct ccaaggaagg ctatctattt tccgataatt acaggacggg ttcaaatcct
     1021 ttctaagata caaagagcct taaaagcaaa gagtacatag gaaactttct tccctatcgt
     1081 cagatacaaa gaaagttact ttttatctca gcttttagct cgtgttcagt ttcgaaatga
     1141 aacaaacacg aggcccttta cctttctatc aatttttcta aaataagcaa agaaacccag
     1201 ttgactacaa ctgagttcat cttctaagca agagcttctg aaatatctac tgaattcgcc
     1261 tcatgccata gcttctctag attataatgg gcacgcattt cctctgaaaa gatatgcacg
     1321 acaacagcac cgaggtccag taagacccag cctccagctg catcgccttc gacatggcta
     1381 cctttaaagc ccgcttgagc tactttttca cggatattag ctgcgatagc gtccaactga
     1441 cggctattca ttgagctagt gatgacaaag tagtccgtca cactagtcaa atcttgtaca
     1501 tcaagtgcaa ggatatcctc cgcacgtttc tcatcagccg ctttcacgac tagttctagt
     1561 aattcttttt cgttcattta atcctctttt tagaaaatat gtttgtaatc taggacatct
     1621 gcaaagcgct cctcccaaat gtcctcataa aattcattaa tcgtttctgc tggaatgtca
     1681 tccccatcaa aggttgtgac agcaccttct ggaacaataa gctgatagcc atattcaaag
     1741 gcaaccttga cagaggtatc cacacaatat tctgtctgca taccacataa aactaatttt
     1801 tcaatcccct gtttatccaa gtattctttt aagccagttt ctttgaaaat actgttatac
     1861 ttcttctgaa agaccttttc agcaggtttt cgatttaaaa gcgcagataa ctgccaatct
     1921 tctgatgttt gagcttcaga gttctcaata tgttgaacat agataatttc aatattcttg
     1981 cttctagcct ggttttgtaa ataagaaatt ttttccaata gactttttgt ctggaaccca
     2041 gtttctacta aaacattctg aacatcaatg attataaaag ccgtcttcat ttagtcctct
     2101 ttcaaatagt gcacaaaggc gttataggtt tcaagggttt ggggatagat ggggaatccc
     2161 tgatgagcta gatactccac ggtacgagct gtttcgtagg ccaccgcctt attgagcgat
     2221 agacttgcaa tctcacgcgc cacatctact ccaggaaagg ctcgattgtg ctcgatatag
     2281 tctgcgacgt agatgacctt atctaggtct gtcatttgac cagctccgac tgtatgaatt
     2341 tcaatggctc gcagaatttc agaatcatgc aaatccaaat cttcctgaat tttgtaaatt
     2401 ccgaccatac catgccagac attattgccc cagtttttga ggtcagggtc tagctggtaa
     2461 cggtcaatca aggctagaaa ttcctgatct gacaactttt tagcatagtc atgaagaaga
     2521 cctgctagac ttgctttctc aacatctaca ccaaagcgct gagctaattc catagcggca
     2581 cgctccacac ctagacaatg ggttagacgt ttctcaggta gaagctctgc cattttttcc
     2641 aacaaggcct cacgggagca gttgatatag tcttgatagg acatcagtag agcccctcct
     2701 tctcgatgta gtctagcact ggctgaggta ggagaaagtt gggtttccga ccttgggcaa
     2761 ggaagtcccg caccatgctg gacgagatat ccatgagcgg tacgtccacc cagataactg
     2821 gataggaagt ccctaccttg tagcgtggac gctgaacccc cacaaactga accatgtcaa
     2881 ccagttcatc aattcggtac cacttaggca gatagtcaac catgtcggca ccgatgataa
     2941 agtaataatc cgtatctgga ttcttctctg tcaaaatctt catggtatcg taggtgtagg
     3001 aaataccctt gcgctccaac tcaatggttt caatgactag gccgtcaatc ccctcaattg
     3061 ccaactcaag catcttgaga cgatggtgtt cagggatggt ttccttttta tcaacgtgag
     3121 gaggttggta ttcaggcatg agaagaactt gatccagtcc caactgttgc cgtacttgat
     3181 ccgcaacaat gagatgggca ttgtgaacag ggttaaaatt cccccctaaa atcccaactt
     3241 gtttgcgttt tttctccttg atttctggct ccaactctac cttggtaaag ggagtcaata
     3301 gttcgattgt cataggctag tcccctttat ttctctataa aaacagttat ttggagtttc
     3361 ggtcttagat ttctttgact ttcttagaaa tcttgcgatt ttctttcttg ctagattgtt
     3421 taaacaaaat caagatgcgt cctatttttt ggactgtatc cacaccgatt tcttcttcca
     3481 aaatttcagc tacttcgtgg atgttttcat ctgtgttttg taagagagta accttgatta
     3541 attcacgcgc atcaagagct tgacggacgc tggttttgat ttggtcgttg agtccatttt
     3601 tcccgatttg gatataggtt tgagggtgtg tgcctggctg ttgaggaagg cacgttgttt
     3661 tgatgttaat gacataattt tcttccttgt tttttgatag ttattttagg tggtgaggga
     3721 cggtcggaac taattttcca aagatttcat ctttgaaaaa tggatttcct gacctcacaa
     3781 ttgagccttg gtctcaattg tgcccccttg ccaatctaca gattggcaat cacaccacgg
     3841 caataactat cgctatgtga gctcactttg ttcgctcagc gattttgttt taaataattg
     3901 cttttcgtgt gacgacggcg acgccttctg gtgcccagac ggcgactttt gctatgcctg
     3961 ttacacgaat ccatcctagg cctgagataa ctaggtctgt cttatcttta atggtaaaga
     4021 catgctggac tagccttggg aaatcttctt tttccttgct atttggtggt gtcagaagag
     4081 ttcccaggtg cttatcgtag aaagcactag ctccttcaag cttgctacga tggagtttga
     4141 gttcattatc aaagaaagca gtaaatcctt gcttttctcc tgctataaag tcaaagcgtc
     4201 ccaaaccacc taaaaatagg gtttgctcag gattaagctg ataggtctta ggcttgattt
     4261 cctttttagg actgacatac ttgaggtttt tggccgtcaa gtagtgagcc atctggtggc
     4321 ggtggataat tcccggcgta tcgtaaatat aagatccgtc gtcaagcgga atctctattt
     4381 tgtccaaggt tgtccctggg aagcgtgaag tagtgatgac attctgatca cccgtgattt
     4441 cttggataat agcattgatt agagttgatt ttccaacgtt ggtcacaccg accacataga
     4501 catcgcggcc cttacggtag tgttcaatct tgtcaatgac ttccttaatg gcatgtttat
     4561 tttgtgctga agttaggacc acatcgactg gacgaagacc ttcttcatgg gcacgtttca
     4621 tgagccactg gctaatctta ccagacttaa ctgacttagg aaggatatct tttttatttc
     4681 ctaccaagag gacatcattg cccgagacga aacgtggtaa acctgggatg acagatccat
     4741 taaaatcaaa gatatcaata acattgacca ctaaagcatc actgtctccc acctcgtgca
     4801 agagcttgag gaaatcatcg ttcgtcaact ggacatctgt gatttcattg tagtggcgga
     4861 gacggaaaca gcgttggcaa tagacttcgc cagtctccaa acctttttca agtgccgact
     4921 gaggggtaaa accaagacca gctttatctg tcgtctgaat ggttgctcca caaccaatac
     4981 agagaatttc ttccatagtt aaattccttt tttatatgta atcggtccgt acttttcagt
     5041 gatttttctc ataacacgac gctcacgagt tcggttaatc tgcgttttga ttgagtcatg
     5101 ttggaccaag ggtttgacta aaattgaccg aatccctgca cggtgggctg ctcgtatatc
     5161 tgtcatgagt tggtcaccaa ccatgaccac ttcctttttg tcatagtgga attccttcat
     5221 agcacggtca ataccaaatg tgaagggctt caaggcccag taaacgtaat caatcccaaa
     5281 tttctcaact gctcgttgaa cgcgtttttt ggtgttattt gacactacga taatgccaat
     5341 acccgcgtcc cgaaggtcat gtagccattg cttcatctct ggcgttccat cagggttgtt
     5401 ccaagcaatg agggtattat ccaaatcgac caaaacagcc ttgattccct gcgcctgcag
     5461 gcttgggact gtcagatcat agactgcttc cacagcaaaa tctggtatat aattttcaat
     5521 cgccattctg gctccttttc ttaacttttt ttcgcaattt tccttagtaa caaggataaa
     5581 acaatccaca aacctgcact agccaaacta atatagagcc aagcatgggg ctcatctgtt
     5641 aaaggtaagg gaacattcat tccgaaaaag cctgtcacga ctgccaaaac agctagcaag
     5701 actgaaataa tagtcaaggt tgtcaaattg tcattcagat tattgtttag aatattgttg
     5761 taagaggctg aaagctgctg taaaatctga gagattaggt ctgtcatgga taccagctga
     5821 tgagcctcaa tcatggcatc atcaaactgt tctctctcaa tctcatcaaa actacgatac
     5881 aaggcatgac cttgaatatg ctctaacaaa atccgatttt gtttggcagc tgccgtcaga
     5941 taaaccatac cagtctccaa atcagacagg gcaaagaggt ttttcttggt agttcgctgg
     6001 cgcaagaggt cattgacctc atccctactc ttgtccatct gctcaatgac aggatagtag
     6061 gcattgctga taatttccag actggcaaag agaaacttat aaatcgaaag cgtgtcatgg
     6121 ctctccagat aacgagtcat ctgttcaatg acataggcgt tcttggtatt actaatggta
     6181 atcaggcgac gatgctcgac aataaaggtc atgggaaaag tctcatagta ggccttgtcc
     6241 ttttttacgt ctaggacatt atagataaag gtaaccgtcc cactttcacg gtggtagtcc
     6301 atgtgggcgc gctcgtttct atccagtgcg tattcaatgg tttccttgtc caaaccgtaa
     6361 atttcagaaa ggtcttctag tttattcaac tttcctaggt ctaggtctat ccaggtacaa
     6421 ccattgccca actgcttttc taaaaccatc ttttctcctt attaaactcc ctctattgta
     6481 ccacaaatta cttaaaataa caggtctagt ctgtgcgtga gaaattgcta acaactgtga
     6541 tatttcggtt agggacaaag tgaagggctt gctcctcgct acgaagctgt gtcgtacgaa
     6601 ttcccacact gacaacctta cccgatacag taatcggtcc atttgtcaga acgacctcat
     6661 ctcccacatc cagttgacgt tcaaagagga tgaaaaagcc attgatgaca tcagacagaa
     6721 agccttgggc tcccatacca atcgctaccc cagcaatacc agctccagcc agcaaactag
     6781 aaactggcaa acctaaaatc gacaaaatgc agtagagtaa aaagaaatat agcgtataat
     6841 taaacacatt ttctagtaaa cgtgagatgg ttttttggcg tccgacatca tgacgagaca
     6901 tttttagaga aggtttgaca attctctgca ccatggtatg aagcattttt ttagcaatat
     6961 aaaatacaat caaaagcagt aaaagagaaa tgaccttggt tagaatattc tcgataatgg
     7021 ttgtcacatc tagcttttca atataagcct gaataaattt ttgcatataa aactccttta
     7081 tttcattata ccatattttc atcagtctca ttctccataa atattcaaaa aatagacaga
     7141 aaattcttga ttttgtctat catttatact ataatcataa tcactacaca aaaaggagat
     7201 tattatgaaa agaatcattc atgcttggaa taaggcaagc cttgtcaagc gtatcttgat
     7261 tggtatgctt tatggggaat cctaggactg acccttccta atctctcagg gattgggcta
     7321 ctcggggatt tattcgttgg aggtctaaaa gctgttgctc ctatcctagt ctttgccctc
     7381 gttgccaatg ccctttccca acatcaaaag ggacaagata gcaatatgaa aactgttgtt
     7441 ttcttgtata tcctatgata gggactttcg ccgctgctct tgtagctgta ctagcaagtt
     7501 tcatcgtccc tattgaaatt accctaaata gtgccaatac tgaaattgca ccaccagatg
     7561 gggttgggca ggttctcagc aacctcttgc tcaaactggt tgacagccca gtcaacgccc
     7621 tgtttactgc taactatatt agaatcttat cttgggcagt catttttgga atcgctatga
     7681 gagaagccag taaaaatagt aaagaattgc taaaaactat cgctgacgtg acttctaaaa
     7741 ttgtcgaatg gatcatcaat ctggctccat ttggaagcct tggtcttgtt tttaaaacca
     7801 tttctgacaa gggagtcgga agccttacca actacggtat tttattggtt ctattagtaa
     7861 cgactatgct ttttgttgcc cttgtggtca ccctttgatt gccttcttct ttatgagacg
     7921 caatccttac cctctagttt ggaactgcct ccgtgtcagc ggtgtgacag cctttttcac
     7981 tcgtagttct gcggctaaca ttcctgtcaa catgaaactc tgccatgacc ttggactcaa
     8041 cccagatacc tattctgttt ctatcccact cggttctact atcaatatgg ctggagtagc
     8101 gattaccatt aacgttttga cccttgctgc agttaacact cttggaattc ctgttgactt
     8161 tgccacagcc tttgtcctca gtgtggtagc agctatctca gcctgtggtg cttcaggtat
     8221 tgccggaggt tccctccttc ttatcccagt tgcttgtagc cttttcggta tttctaacga
     8281 tattgccata caagttgttg gggttggttt tgtgattggt gtcatccaag actcatgtga
     8341 aacagccctt aactcttcta cagatgtcct ctttaccgcc gttgccgaat acgcagcaac
     8401 ccgtaaaaaa taactcatca aggcaagcct gctcatgtct tgtcttttac gcttttattc
     8461 taacttatta ggaaattctt atgtctatta gccaacgtac gaccaagctc atcttagcta
     8521 cctgtcttgc ctgcctgctt gcttattttc tcaatctttc atcagcagtt tcggctggaa
     8581 ttatcgctct cttgagccta tctgatacgc gtagaagtac tttaaaactg gctcgcaatc
     8641 gtcttttttc tatgcttcta gctctggcta tcggtgttct agcttttcac ttgagcggat
     8701 ttcatatctg gagtctcggc ctctatctgg ccttctacgt tcctttagcc tacaagatgg
     8761 gctgggaaat tggcatcaca ccaagcactg ttttggttag ccatctcttg gttcaagagt
     8821 caacctctcc agaccttcta gtcaatgaat tccttctctt tgctattggt acaggatttg
     8881 ccttgcttgt taatctctat atgccttcac gagaagagga aatccagcac taccacacgc
     8941 tggtggaaga aaagttaaaa gatatcctcc agcgcttcaa atactattta tccagaggag
     9001 acggacgcaa ccgagcacag ctggtagcag aattagacac gcttttgaaa gaagccctca
     9061 gactggtcta tttggatcac tctgaccacc tctttcacca gaccgactac catatccact
     9121 actttgagat gagacaacga caaagtcgta tcctgagaaa catggcccaa cagattaaca
     9181 cttgtcacct tgccgccagt gaaagcctga tcttagcgca actcttttca aaaattgcag
     9241 gtcaactgag ccagaccaat cctgcttctg atttgctaga tgaaattgaa cgttatctgg
     9301 aagtcttccg gaaccgcagt ctgcccaaga caagagaaga atttgaaacc cgcgccaccc
     9361 ttcttcaact cctacgtgaa gccaaaacct tcatccaagt aaaagttgat ttttaccaaa
     9421 aatatagaca gtaaaaaata aaaccactaa aaaacagagc ttgccagcat tcttgaaaag
     9481 tagtataatt attgcatgcg caatcatctt gtgacgcaga gactgcccgt taatggactt
     9541 tcttctattt atgactctaa aaagaaagga gacactatga cctatttgga aaaatggttt
     9601 gacttcaatc ggcgtcagaa agaaattgaa agtctcttgg aagagaccat tgcccaacag
     9661 agcgagcaaa gtctgacctt gaaagagttc tacctgctct actatctgga cttggctgaa
     9721 gaaaaatctc tacgccagat tgacctgcca gataaacttc atctgagccc gagcgcagtt
     9781 tctaggatgg tggctcgctt ggaagctaaa aattgcggtc tactcagtcg catgtgttgc
     9841 catcaagata gacgctctag ttttatctgc ctgacaaatg atgggcaaaa gacactggcc
     9901 tcgctacaaa agactgtcga agaaagcttg gaagcaggtt tggatttctt gatttaagat
     9961 gatttttaaa aaaagttgcg tgcgcaatca tttttcttga cattctcttt tataaggagt
    10021 aaaataaagt tagcattaaa caaaggagtt ttaaatatga ttgaaattac ctatatagat
    10081 gccagcaaga acgaaagaac tgtgactttc gagtcttatg aagactttga acgttcgcaa
    10141 caagcttgcc ttatcggcgt cgcagactac taccctgtcc aaaaattaac ttacaagggt
    10201 cataatttgg actaccatgg gacttatgga gatatcttct tctatctcat gaaacaagat
    10261 ttaagccaat ataactaaaa aaaggagaaa tacaatggca aaagcaatta cagatgcaac
    10321 attcgaacaa gaaacaaaag atggtttggt cttagtagac ttctgggcaa cttggtgtgg
    10381 tccatgtcgt atgcaaggtc caatcttgga caaattgtct gaagaacttt cagaagatgt
    10441 cttgaaaatc gttaaaatgg acgttgatga aaatccaaac acagctcgtg cttttggaat
    10501 catgtctatt ccaactcttc tcttcaaaaa agacggccaa gttgtcaaac aagttgcagg
    10561 tgttcacaca gcagaacaaa tcaaggccat cattgctgaa ttgagctaat caaacgagag
    10621 accaagtact ttctttggtc tcttttttct tgccctttgc catttttcaa aaaatatgct
    10681 agactatagt agattgaaac tagaatagta cacctctact tctaaaacat tgttagaaat
    10741 cgatttaact gtcctgatcg atttgtcctg ttcttatttc attttactat ataagtagaa
    10801 tattacgatg tttgggatat gccatcgcta aaaaaactcg atttggtatt ttttagctcc
    10861 ctaataggag ctttttgcat gctctgaaca tttcccattt tggaaggagt actatgaaac
    10921 gtcaatcagc cttggtcgtc tttagtggtg gtcaagattc aacaacctgc cttttctggg
    10981 ttatgcaaca ctatgaaaca gtcgaagctg tcacctttgc ctacggccaa cgtcatcacc
    11041 tcgaaattca aattgctaga gaaatcgcta aggaacaggg cattcgtcac catatcctcg
    11101 atatgtctct gctgggacaa atcactgctc agccagactt tgcgacgatt catatttcct
    11161 acattcctga caagctctgt gtcgagtcaa aatccctcaa actatatcta tttagctacc
    11221 gaaatcacgg agatttccac gaaaactgta tcaacaccat cgggaaagac ttggtcaact
    11281 tgctagaccc tcgctattta gaagtctggg gaaaattcac tccgcgcggt ggcatttcaa
    11341 tcgaccccta ctacaactac ggtaagcaag gaactaagta tgaggacttg gcagaacaac
    11401 gcctcttcca acacgacctt tatccagaga aaattgacaa ccgctaaagt catactcaat
    11461 gaaaatcaaa gagcaaacta ggaagttagc cgcaggttgc tcaaagcagt gtttgaggtt
    11521 atagataaga ctgacgaagt cagctcaaaa cactgttttg aggttgcaga tagaactgac
    11581 gaagtcagct taaaacactg ttttgaggtt gtagatagaa ctgacgaagt cagcttaaaa
    11641 cactgttttg aggttgcaga tagaactgac gtagtcagta accataccta cggcaaggta
    11701 aagctgacgt ggtttgaaga gattttcgaa gagtatcata cgaaaaagcc ctgttcctca
    11761 agatgaggag caaggctttt tgagtttcaa ttatttttct gttccaagga aattttttgc
    11821 aacaagggct gcaagaactc caccagcgat tggtgcaagg atgaaaatcc aaacttgttg
    11881 aagggctgcg ccgcctacca agacagctgg tgccaagcta cgagctgggt ttactgaaag
    11941 tccagtaatc ttcaatccga caagaatcat cgccatcaat gacaaaccga ttaccaaacc
    12001 agcaatcgcg ccattgccct tactttctga agtcacagtc ataataacta agacaaacaa
    12061 gaaagttgca atgacttcaa acaagaaacc accaaagaca gtgacaccgt ttgccaaggc
    12121 attttcacca agactagcag ttgacatacc tgaattagcc aagaggaaga agactgcgcc
    12181 agaagcgatg aaagctccaa caacctgacc aaggatgtag tttacaagtt ctgaagatga
    12241 caaacgtttg tttacaaaca tagcaatcga aacagccggg ttcaagtgag cacctgaaac
    12301 agttccgatt gagtaggctg ccaccacgat tgccaaacca aaggcaaagg cgattccaag
    12361 gtgaccaagg ccatcaagac catttccaaa aacaacagct cctgtcccaa cgaacacaag
    12421 catgaacgta ccgattaact cagcaacaaa ttttttcatt ttctttctcc ttttttcaaa
    12481 aactagatac tagtctatca aaagtaggaa agggtttcaa gaaaattgat tggaaatttt
    12541 ttgaaaatca tagaactatt agctaatctc tagtattgaa aagactggat agcttctttc
    12601 aactcatctt gtaaactatt tctctggtca agttggacat agacttccac cagacaggat
    12661 ctaaagttgg aaaatttgta aaaatcctcc ctttcttcta tcggaaaatc aacagttttt
    12721 atccaagaag ctacttgttc ttgctccaac ttcccttata aaataggttc atagatcact
    12781 cttgctaaac gccaatcctc atcatctgta aagcgaatcg acatcctttt aaatagttgg
    12841 ccaagtatat caaatacttc atgaactctg tttttaggaa agtctggatg acaaaccacc
    12901 tctgtcagta aatcggctcc atgtgcaaaa gcgtgaaccc aaccatactg acttgagaaa
    12961 cctgttgtat ccttttcttt tgaaagatag tgcaagcctt gatttgaaag gtcattacga
    13021 aatcctgcat ttaattcctg ataaaaaacc gattgctggt tggcatcgtc agacaagaga
    13081 gttgcataaa taagcgccct aaaagaacgt tcaagtgttg gcaggcctat cttatcaatc
    13141 tctttatcta accctccatc agatgaaacc ccttcagcaa tgaaatgaaa ttgttcctgt
    13201 gtaaatagct cttcctgaat ccctctagca aagcttgtaa aaacaaggtc atcacgaatt
    13261 tctggagaag gatctcccaa atgatcaagc aaccactgga tttcctcctg gttataattt
    13321 ggtttttctt ctgctatttt tcttagtaaa tcttgataca tggtcaatac ctctacattt
    13381 ctagcaactg ttcaaaaagg cagtcttaaa tgaccttacc aatttgtaaa attaagttaa
    13441 aaagaaaaag acatttatat tcagagaaac agcatatttc tgaaaagata tataaatga
//
LOCUS       DAVLHC010000046        12799 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.047, whole genome shotgun sequence.
ACCESSION   DAVLHC010000046 DAVLHC010000000
VERSION     DAVLHC010000046.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 12799)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12799)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12799
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.047"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(417..2144)
                     /gene="ezrA"
                     /locus_tag="VXE25_001682"
     CDS             complement(417..2144)
                     /gene="ezrA"
                     /locus_tag="VXE25_001682"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000064817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septation ring formation regulator EzrA"
                     /protein_id="HEV0772110.1"
                     /translation="MSNGQLIYLMVAIAVILVLAYVVAIFLRKRNEGRLEALEEKKEE
                     LYNLPVNDEVEAVKNMHLIGQSQVAFREWNQKWVDLSLNSFADIENNLFEAEGYNHSF
                     RFLKASHQIDQIESQITLIEEDIAAIRNALADLEKQESKNSGRVLHALDLFEELQHRV
                     AENSEQYGQALDEIEKQLENIQSEFSQFVTLNSSGDPVEAAVILDNTENHILALSHIV
                     DRVPALVTTLSTELPDQLQDLEAGYRKLIDANYHFVETDIEARFHLLYEAFKKNQENI
                     RQLELDNAEYENGQAQEEINALYDIFTREIAAQKVVENLLATLPTYLQHMKENNTLLG
                     EDIARLNKTYLLPETAASHVRRIQTELESFETAIVEVTSNQEEPPQAYSVLEENLEDL
                     QTQLKDIEDEQISVSERLTQIEKDDINARQKANVYVNRLHTIKRYMEKRNLPGIPQTF
                     LKLFFTASNNTEDLMVELEQKMINIESVTRVLEIATNDMEALETETYNIVQYATLTEQ
                     LLQYSNRYRSFDERIQEAFNEALDIFEKEFDYHASFDKISQALEVAEPGVTNRFVTSY
                     EKTRETIRF"
     gene            complement(2226..4172)
                     /gene="gyrB"
                     /locus_tag="VXE25_001683"
     CDS             complement(2226..4172)
                     /gene="gyrB"
                     /locus_tag="VXE25_001683"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002283665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase (ATP-hydrolyzing) subunit B"
                     /protein_id="HEV0772111.1"
                     /translation="MTEEIKNLQAQDYDASQIQVLEGLEAVRMRPGMYIGSTSKEGLH
                     HLVWEIVDNSIDEALAGFASHIQVFIEPDDSITVVDDGRGIPVDIQEKTGRPAVETVF
                     TVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSTQLDVHVHKNGKIHYQEYRRGHVVAD
                     LEVVGDTDRTGTTVHFIPDPKIFTETTTFDFDKLNKRIQELAFLNRGLQISITDKRQG
                     LEQTKHYHYEGGIASYVEYINENKDVIFDTPIYTDGEMDDITVEVAMQYTTGYHENVM
                     SFANNIHTHEGGTHEQGFRTALTRVINDYARKNKLLKDNEDNLTGEDVREGLTAVISV
                     KHPNPQFEGQTKTKLGNSEVVKITNRLFSEAFSDFLMENPQIAKRIVEKGILAAKARV
                     AAKRAREVTRKKSGLEISNLPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQ
                     AILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQKLVLMTDAD
                     VDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPIYGVKVGSEIKEYIQPGADQEIKLQ
                     EALARYSEGRTKPTIQRYKGLGEMDDHQLWETTMDPEHRLMARVSVDDAAEADKIFDM
                     LMGDRVEPRREFIEENAVYSTLDV"
     gene            complement(4187..4750)
                     /locus_tag="VXE25_001684"
     CDS             complement(4187..4750)
                     /locus_tag="VXE25_001684"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HEV0772112.1"
                     /translation="MKYHDYIWDLGGTLLDNYETSTAAFVETLALYGITQDHDSVYQA
                     LKVSTPFAIETFAPNLENFLEKYKENEARELEHPILFEGVSDLLEDILNQGGRHFLVS
                     HRNDQVLEILEKTSIAAYFTEVVTSSSGFKRKPNPESMLYLREKYQISSGLVIGDRPI
                     DIEAGQAAGLDTHLFTSIVNLRQVLDI"
     gene            complement(4835..5389)
                     /locus_tag="VXE25_001685"
     CDS             complement(4835..5389)
                     /locus_tag="VXE25_001685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DJ-1/PfpI family protein"
                     /protein_id="HEV0772113.1"
                     /translation="MVKVAVMLAQGFEEIEALTVVDVLRRANITCDMVGFEEQVTGSH
                     AIQVRADHVFDGNLSDYDMIVLPGGMPGSAHLRDNQTLIQELQSFEQEGKKLAAICAA
                     PIALNQAEILKNKRYTCYDGVQEQILDGHYVKETVVVDGQLTTSRGPSTALAFAYELV
                     EQLGGDAESLRTGMLYRDVFGKNQ"
     gene            complement(5400..6623)
                     /locus_tag="VXE25_001686"
     CDS             complement(5400..6623)
                     /locus_tag="VXE25_001686"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000830656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsW/RodA/SpoVE family cell cycle protein"
                     /protein_id="HEV0772114.1"
                     /translation="MKRSLDSRVDYSLLLPVFFLLVIGVVAIYIAVSHDYPNNILPIL
                     GQQVAWIALGLVIGFVVMLFNTEFLWKVTPFLYILGLGLMILPIVFYNPSLVASTGAK
                     NWVSINGITLFQPSEFMKISYILMLARVIVQFTKKHKEWRRTVPLDFLLIFCMILFTI
                     PVLVLLALQSDLGTALVFVAIFSGIVLLSGVSWKIIIPVFVTAVTGVAGFLAIFISKD
                     GRAFLHQIGMPTYQINRILAWLNPFEFAQTTTYQQAQGQIAIGSGGLFGQGFNASNLL
                     IPVRESDMIFTVIAEDFGFIGSVLVIALYLMLIYRMLKITLKSNNQFYTYISTGLIMM
                     LLFHIFENIGAVTGLLPLTGIPLPFISQGGSAIISNLIGVGLLLSMSYQTNLAEEKSG
                     KVPFKRKKVVLKQIK"
     gene            complement(6660..9110)
                     /locus_tag="VXE25_001687"
     CDS             complement(6660..9110)
                     /locus_tag="VXE25_001687"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional DnaQ family
                     exonuclease/ATP-dependent helicase"
                     /protein_id="HEV0772115.1"
                     /translation="MKTIGNRYVVVDLEATSTGSKAKIIQVGIVVIEDGEIVDHYTTD
                     VNPHEPLDAHIKELTGLTDQRLAQAPDFSQVARKIFDLVEDGIFVAHNVQFDANLLAE
                     NLFFEGYELRNPRVDTVELAQVFFPELEKYSLPILCRELGIPLKHAHTALSDAQATAE
                     LLLFLREKMTQLPKGLLERLLEMADALLYESYLVIEETYRNQSILSSPDLVQVQGLYF
                     KKTAASLELRKLSQDFSKNISLLNLEVREEQESFAKEVGLLLKDEPVFLIQAPTGIGK
                     TYGYLLPALSQSKERQIVLSVPTKILQNQIMEEEGKRLKEVFHTDIHSLKGPQNYLKL
                     DAFYHSLQENDENRLFRRFKMQVLVWLTETETGDLDEIGQLYRYQHFLADLRHDGNLS
                     SQSLFVTEDFWKRSQERAETCKLLVTNHAYLVTRLEDNPEFVSDRLLIIDEVQKILLA
                     LENLLQETYDIQSIIDLIDKALVGEENRVQQRILESIRFECLYLIEQFQSGKSRKNIL
                     DSLDNLHQYFSELEVEGFDELVRYFTAEGDYWLEVTETSQKKIQISSTKSGRTLLSSL
                     LPESCQVLGVSATLEISQRVSLADLLGYPEAKFVKIESRGKQEQEVVMVKDFPLVTET
                     SLEVYAREVAALLVEIQAFQQPILVLFTAKDMLLAVSDLLTVSHLAQYKNGDVHQLKK
                     RFEKGEQQILLGAASFWEGVDFSSHPFVIQVVPRLPFQNPQEPLTKKINQELNQEGKN
                     AFYDYQLPMAIIRLKQALGRSMRREYQRSLTLILDRRIVGKRYGKQIVASLAEEATVK
                     TISRSEVDEAIDRFFNEL"
     gene            complement(9310..10239)
                     /locus_tag="VXE25_001688"
     CDS             complement(9310..10239)
                     /locus_tag="VXE25_001688"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006154193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="U32 family peptidase"
                     /protein_id="HEV0772116.1"
                     /translation="MEKIVITATAESIEQVEQLLEAGVDRIYVGEKDFGLRLPTTFSY
                     DQLREIAKLVHDAGKELIVAVNALMHQDMMDRIKPFLDFLEEIKIDYITIGDAGVFYV
                     VNRDGYSFKTIYDASTMVTSSRQINFWGQKAGASEAVLAREIPSAELFKMPEILEIPA
                     EVLVYGASVIHHSKRPLLQNYYNFTHIDDEKTHKRDLFLAEPSDPESHYSIFEDNHGT
                     HIFANNDLDLMIKLTELVEHGFTRWKLEGLYTPGQNFVEIAKLFIQARNLIQEGNFSH
                     DQVFLLDEEVRKLHPKNRFLDTGFYDYDPDMVR"
     gene            10379..10666
                     /locus_tag="VXE25_001689"
     CDS             10379..10666
                     /locus_tag="VXE25_001689"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001145225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3270 domain-containing protein"
                     /protein_id="HEV0772117.1"
                     /translation="MPVRKLQSYEVDYQEELNQQLPHYQAYTPEAQSDANLKEILFFI
                     NIAVFCICIAIFSFIFLALKLSTALAFAAAIGFSLLVLKVQRSIIKRKRRR"
     gene            complement(10700..12034)
                     /gene="ciaH"
                     /locus_tag="VXE25_001690"
     CDS             complement(10700..12034)
                     /gene="ciaH"
                     /locus_tag="VXE25_001690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000491790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system sensor histidine kinase
                     CiaH"
                     /protein_id="HEV0772118.1"
                     /translation="MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLY
                     TSVDDKLHGLSENPQAVIQLAINRATEEIKDLENARADASKVEIKPNVSSNTEVILFD
                     KDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
                     IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQ
                     SFVENASHELRTPLAVLQNRLETLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLN
                     LARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRIHRTIVTDQLLLKQL
                     MTILFDNAVKYTEEDGEINFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKA
                     RTRQKGGFGLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIAIQTPSKKKK"
     gene            complement(12024..12698)
                     /gene="ciaR"
                     /locus_tag="VXE25_001691"
     CDS             complement(12024..12698)
                     /gene="ciaR"
                     /locus_tag="VXE25_001691"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256510.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system response regulator CiaR"
                     /protein_id="HEV0772119.1"
                     /translation="MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGV
                     YDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTAKESLDDKGHGFELGADDYLTKP
                     FYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
                     FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGY
                     LLKDVQ"
BASE COUNT         3889 a         2732 c         2275 g         3903 t
ORIGIN      
        1 cctatttacc gtggactaaa gttgtacaag aaaagtgcaa ataagaaatc tccagattag
       61 gaactatccg tgagttctct agtctggaga tttttcaata tacttcgtta ttggacggtt
      121 accaagttac tcaaagtaca gatttgaagc tgcagataag actgacgaaa tcactttaat
      181 actaaatgaa aatcaaaaag caaactaaga agctagcctc aggctgtact tgagtacggt
      241 aaggcgacgc tgacgtgatt tgaagagatt ttcgaagagt ataaaacact gttttgaggt
      301 ggtggataaa tcggctgggt aaaaactcaa tctcaggaga aaatgaagta aatctcccca
      361 caactataga aaaagatttg attctgctcc tcacacaata aaatcttttt cttttattaa
      421 aaacgaatcg tttcacgtgt tttctcatat gaggtaacaa agcgattagt tacaccaggc
      481 tctgccactt ccaatgcttg agaaatcttg tcaaatgaag cgtgataatc aaattctttt
      541 tcaaaaatat ctaaagcttc gttaaatgct tcttgaatgc gttcatcaaa tgagcgatag
      601 cggttagaat attgcaagag ttgctctgtc aaagttgcat attgtacaat attataagtt
      661 tccgtttcta aagcttccat atcattcgtt gcaatttcaa gaactcgggt aacagattca
      721 atgttaatca ttttttgttc taactcaacc attaaatcct cggtattatt gcttgccgta
      781 aagaataact tcaagaaagt ttgtggaata cctggcagat tgcgtttttc catgtatcgc
      841 ttgatagtat ggagacgatt gacataaaca ttggcctttt gacgtgcatt aatatcatct
      901 ttctcaattt gtgtcaggcg ctcactaact gaaatttgct catcttcaat atcttttagt
      961 tgagtttgta aatcctcaag attttcttca agaactgaat aagcttgggg tggttcttct
     1021 tgatttgaag ttacctcaac aatagctgtc tcaaaactct ctaattctgt ctgaatacga
     1081 cgaacatggc ttgcagctgt ctcaggaagt aaataggtct tgttcaaacg tgcaatatct
     1141 tctcccaata aagtattatt ctctttcata tgttgaagat aagttggaag agttgcaagt
     1201 agattttcca ctactttctg agcagcaatt tctcgagtaa aaatatcata caaggcattg
     1261 atttcctctt gtgcctgtcc attctcatat tcggcattat ccaattccaa ctgacgaata
     1321 ttctcttggt ttttcttgaa tgcttcataa agcaagtgga aacgcgcttc aatatccgtt
     1381 tcaacaaaat gataattagc atcaattagt ttacgataac cggcttccaa atcctgtaat
     1441 tgatctggca attctgtaga aagcgtcgta accaaggctg gaacacgatc cacaatatga
     1501 cttaaggcca aaatgtgatt ttctgtatta tccaaaatca ctgcggcttc cacagggtca
     1561 cccgatgaat tcaaggttac aaattgtgaa aattcagatt ggatattttc taattgtttt
     1621 tcaatttcat ccaaggcttg accatactgt tctgaatttt cagcaactct atgctgaagt
     1681 tcctcaaata aatccaaagc atgaagaaca cgaccactat ttttagattc ttgcttctct
     1741 aagtctgcca aagcattgcg aattgccgca atatcttctt caatcaaagt aatttgactc
     1801 tcaatttggt caatttgatg actggccttg agaaaacgaa atgaatggtt ataaccttct
     1861 gcttcaaaga gattattttc aatatcggca aaagagttga gagataaatc gacccatttt
     1921 tgattccatt cacggaaagc cacttgactt tgtccaatca agtgcatatt ttttacagct
     1981 tctacttcat catttactgg aagattgtat agttcttctt ttttttcttc tagcgcctct
     2041 aatctcccct cgtttcgctt acgtagaaag attgccacta cataagccag aactaaaatg
     2101 actgcaattg caaccattaa ataaattagt tgtccattag acatatcaaa ctcctttttt
     2161 acttgaaaca atcgtaacga ttatatcata ttttttagac caagggaact acttctccct
     2221 attttttaga catcaagtgt actatagaca gcattttctt cgataaactc acgacgaggc
     2281 tctactcgat cccccatcaa catatcaaag attttatctg cttctgcagc atcatctaca
     2341 gaaactctag ccatcaagcg atgttcggga tccatggttg tttcccacag ctgatgatcg
     2401 tccatttcac ctagcccctt ataacgctga atagtcggtt tggtacgacc ttcactataa
     2461 cgggctaaag cttcttggag tttgatttct tgatctgcac ccggctggat atattcttta
     2521 atctcgcttc caaccttgac accatagatt ggtggttggg caatataaac ataaccagct
     2581 tctaggattg gtttcatata acgataaatc aaggttaaaa gaagggtacg aatatgggct
     2641 ccatcgacat cggcatcggt catcaaaacg agtttttggt aacgggcttt cgaaacatca
     2701 aattctgcgc caaatcctgt tcccatggct gtgaaaagac tacgaatttc ttcgttagct
     2761 agaatcttat ccatacttgc tttttcaacg ttcaaaatct taccgcgaat tggaaggata
     2821 gcctgaaact cacggttacg accagatttg gctgatccac cagctgagtc tccttcgacg
     2881 atgaagagtt ctgtttcagc agggttatta gaagaacagt ctgctagttt ccctggaagg
     2941 ttggaaattt ccaaaccaga ttttttacgt gtgacttcac gcgcacgctt ggcagccaca
     3001 cgagccttgg cagctaaaat ccctttttcc acgatacgtt tggcaatctg tggattttcc
     3061 atgaggaaat cggagaaggc ttcactgaag aggcgattgg taatcttgac cacttcgcta
     3121 tttcccaatt tggtcttggt ttgtccttca aactgtggat ttgggtgttt aactgagata
     3181 actgcagtta atccttcgcg aacatcttcc cctgttaaat tatcttcatt gtctttcagt
     3241 aacttattct tacgagcata atcattgata acacgagtca gtgccgtacg gaaaccttgt
     3301 tcatgcgttc caccttcatg ggtatgaata ttattggcga aactcatgac attttcatgg
     3361 taacctgttg tgtactgcat ggctacctca actgtaatat catccatctc accgtctgta
     3421 tagattggtg tatcaaagat tacatccttg ttctcgttga tatattcaac gtaactagca
     3481 atcccacctt cataatgata atgcttggtt tgttccaaac cttggcgctt atcagtgata
     3541 gaaatttgaa gaccgcgatt tagaaaggcc aactcttgaa tccgtttatt taatttatca
     3601 aaatcaaagg ttgttgtttc agtaaagatt tttgggtccg gtatgaagtg aaccgttgtt
     3661 ccagttctat ctgtatcccc aaccacctca aggtctgcaa caacatgacc acgacggtat
     3721 tcttggtaat gaatcttacc gtttttatgg acatgaacgt ctaattgagt ggaaagggca
     3781 ttaactactg acgaccccac cccgtgaaga ccacctgaaa ccttgtatcc accaccgccg
     3841 aactttcctc cagcatgaag gactgtaaag acggtctcaa cagcaggacg gcctgttttt
     3901 tcctgaatat cgactgggat accacgccca tcatccacaa cagtaatcga atcatctggc
     3961 tcaataaaaa cttgaatatg gctggcaaat cctgccaagg cctcgtcaat tgagttatca
     4021 acaatttccc agactagatg gtgaagacct tcttttgagg ttgatccaat gtacatccct
     4081 ggacgcatac gaacagcctc taaaccctct aaaacttgaa tttgactggc atcataatcc
     4141 tgtgcctgca gatttttgat ttcttctgtc atcttattcc tttttcttat atgtctaata
     4201 cttgtcttaa attcacgata ctggtaaaca agtgggtatc aagtcctgca gcttgacctg
     4261 cttcgatatc aatcggccga tcaccaatga caagaccaga gctaatctga tacttttctc
     4321 ttaaataaag catggattcg ggatttggct ttctcttaaa gcctgagcta gaagtcacca
     4381 cttctgtaaa ataagctgct atagaggttt tttctaaaat ttccaaaacc tgatcatttc
     4441 gatgagagac caaaaaatga cggccacctt gatttaaaat gtcttccaat aggtcagaaa
     4501 ctccttcaaa taaaatcggg tgttcaagct ctctggcttc attttccttg tacttttcta
     4561 aaaaattctc taaattggga gcgaatgtct caatcgcaaa aggagtagaa acctttaaag
     4621 cttgatagac actgtcatgg tcttgtgtga taccatacag tgccaatgtt tcaacaaatg
     4681 cagctgttga agtttcataa ttatccagta aagttccacc taaatcccag atgtaatcgt
     4741 gatatttcat acccttcatt atagcatttt tttatgaaaa aagcgatgat ttccctgagt
     4801 tttccacata aaaaacgaga gaataactcc cgttttactg atttttacca aagacatctc
     4861 gatagagcat tcctgttcgt aaactctctg cgtcccctcc tagttgctcc accaactcgt
     4921 aggcaaaggc aagggctgtt gaaggacccc gactggttgt caactgacca tctaccacta
     4981 ctgtttcctt gacgtagtga ccatcaagga tttgctcttg aacgccgtca taacaagtgt
     5041 atcgcttatt tttcaatatc tctgcttgat tgagggcaat tggtgccgca caaatggctg
     5101 ctagtttctt cccttcttgc tcgaagcttt gcaattcttg aatcaaggtc tgattatcac
     5161 gtaaatgtgc agaaccaggc atacctccag gaagaacaat catatcatag tctgataaat
     5221 ttccatcaaa gacatgatct gctcttactt ggattgcatg cgaacccgtt acttgctctt
     5281 caaaaccaac catatcacat gtgatattgg ctcgacgcaa gacatctaca actgtcaagg
     5341 cttcaatttc ttcaaagccc tgagctaaca taactgctac ttttaccatg attttctcct
     5401 tatttaattt gttttaatac aacctttttc cgtttgaatg ggacttttcc gctcttttct
     5461 tcagctagat tagtctggta actcatcgat aaaagcaaac caacaccaat cagattactg
     5521 ataatagctg atcccccttg cgaaatgaaa ggcaagggaa tccccgtcaa aggaagtagt
     5581 ccagtcacag caccgatatt ctcaaagatg tggaagagca acatcataat caaacctgtg
     5641 gaaatataag tgtagaactg gttatttgat ttaagagtaa tcttcaacat acggtaaatc
     5701 aacatgagat agagggcaat aaccaggaca gagccaataa agccaaaatc ttctgcaata
     5761 accgtaaaaa tcatatctga ctctcgaact gggataagca gattcgaagc attaaatccc
     5821 tgaccaaata agccaccact cccaatggca atctgccctt gagcctgctg gtaagtcgtt
     5881 gtttgggcaa actcaaaggg attgagccaa gccaaaatcc gattaatttg gtaggtcggc
     5941 attccaatct ggtgaagaaa agctcgtccg tccttgctaa taaagatagc taagaaacca
     6001 gcaactcctg ttacagcagt cacaaatact gggataataa ttttccaaga aacccctgat
     6061 aataaaacga ttcctgagaa aatggctaca aaaaccaaag ccgtccccaa gtcactttga
     6121 agtgctaaaa gaactaggac tggaatggta aagagaatca tacagaaaat taacaaaaag
     6181 tccagcggaa ccgtgcgtct ccattcctta tgtttctttg taaattggac aatgacacga
     6241 gccaacatga ggatatagga tatcttcata aattctgacg gttggaatag ggtaattcca
     6301 tttattgata cccagttttt ggcacccgtt gatgcaacta agcttggatt ataaaataca
     6361 atcggcaaga tcataagtcc caagcctaaa atatatagaa agggggtcac cttccaaaga
     6421 aattctgtat taaagagcat gaccacaaaa ccaatcacaa gccccaaggc aatccaggcg
     6481 acctgctgcc ctaaaatggg cagaatatta ttggggtaat catgactaac ggctatatag
     6541 atagccacca caccgatgac cagtagaaaa aatactggca agagcaaact gtaatcgact
     6601 cttgagtcga gagaacgttt catatatact aaccttatac tttcatacaa tactatttat
     6661 caaagttcat taaaaaatct atcaatagcc tcgtcaactt cggatcgaga gatggtttta
     6721 acagtcgctt cttctgctag agatgctact atttgtttgc cgtatcgttt tccgacgatt
     6781 ctcctatcca aaataagagt taaggaacgt tggtattcac gtctcatact tcttcccaaa
     6841 gcctgtttta aacgaataat ggccattggc aattgataat cataaaaggc atttttccct
     6901 tcttgattca gttcttgatt aatctttttc gtcaagggtt cttgaggatt ttggaaagga
     6961 agcctcggta caacttgaat cacaaaagga tggcttgaaa aatcaactcc ctcccagaaa
     7021 cttgctgcac caagcaagat ttgttgttca cctttttcaa agcgtttctt tagctgatga
     7081 acatccccat ttttatactg ggccaagtgg ctaactgtaa gtaaatccga tactgctaga
     7141 agcatgtctt tagcggtaaa gagaaccaaa atcggttgct ggaaagcttg aatttccact
     7201 agtaaagcag ctacctctct ggcatagact tctaaggagg tttctgttac cagagggaaa
     7261 tctttgacca tgaccacttc ttgttcctgt tttccccgag attcaatctt gacaaattta
     7321 gcttcaggat agcctaaaag gtctgccaaa gaaaccctct gactaatctc aagagtagcc
     7381 gatactccca ggacttggca actctcagga agtaaagagg acagaagagt acggcctgat
     7441 tttgtagaag aaatctgaat tttcttttga ctcgtttcag ttacttcaag ccagtaatca
     7501 ccttcagctg taaaatagcg aaccagctca tcaaagcctt ctacttctaa ttctgaaaaa
     7561 tactgatgga gattgtccag agaatctaag atatttttcc tagatttacc agactgaaat
     7621 tgttctatca agtagagaca ctcaaagcga atactttcta gtatccgttg ttgaaccctg
     7681 ttttcttctc ctactaaagc cttatcaatt aaatcgataa tagattgtat atcgtaggtc
     7741 tcttgaagca gattttctag agctaacaaa atcttttgga cttcatcaat aatcagtaaa
     7801 cggtcactga caaattcagg attatcttca agtctggtca cgagataggc atgattagtc
     7861 actaaaagct tgcaagtctc tgccctttct tgactacgtt tccaaaaatc ttccgtcaca
     7921 aataagctct gggatgataa attcccatca tgacgaaggt ctgctagaaa atgttggtaa
     7981 cggtagagtt gcccgatttc atccaaatct cctgtctctg tctcagtaag ccagaccaag
     8041 acttgcattt taaagcgtct aaataagcga ttttcatcat tttcctgcaa ggaatgataa
     8101 aaggcatcca acttcagata attttgtggt ccctttaagc tatgaatatc tgtatggaac
     8161 acttccttga gacgtttacc ttcttcttcc atgatttgat tttgaagaat ctttgtcgga
     8221 acactaagaa caatttgtcg ctctttggat tgagataaag cgggtaagag atagccatag
     8281 gttttcccaa tccctgtcgg cgcttgaatc agaaagacag gttcatcttt caatagcaag
     8341 ccaacctctt tagcaaaact ttcttgttcc tccctcactt caaggttcaa cagagaaata
     8401 tttttagaaa agtcttgaga tagttttcgt agctccagag aagctgccgt tttcttaaaa
     8461 tacagacctt gaacttggac caagtctgga gaactcagga tagattggtt gcgataagtt
     8521 tcctcaataa ccaggtagga ctcatatagg agagcgtcag ccatttccag caagcgttcc
     8581 aagagacctt taggaagctg ggtcatcttt tcccgtaaaa aaagaagtaa ttctgctgta
     8641 gcttgggcat ctgaaagggc tgtgtgtgcg tgtttaagag gaattcctaa ttctcgacac
     8701 aaaatcggca agctatattt ttccagttca gggaaaaaga cctgggccaa ttcgaccgta
     8761 tcaacacgag ggtttcttag ctcatagcct tcaaaaaata aattttccgc caagagatta
     8821 gcatcaaact gaacattatg ggctacaaaa atcccatcct ccaccaagtc aaatattttt
     8881 ctggcaactt gcgaaaaatc aggtgcttgc gccagacgtt ggtctgtcaa tcctgtcagt
     8941 tctttgatat gagcatccaa gggttcatgt ggattgacat ccgtcgtata gtgatcgacg
     9001 atttctccgt cctcaatcac gacaattccc acttggataa ttttagcctt actacctgtg
     9061 ctagttgcct ctaaatccac cacaacatag cgattaccaa tcgttttcat tataaaaaat
     9121 tataccaaaa aaagggccat ttggcacctg caaacatagg ataattttca aactcaagaa
     9181 cactactttt cttaaaaatc ccatcgaata gagcattcta gcctgctgat ttttgtaaaa
     9241 tagtgaagaa atacgaaaaa ttgagagaag aaatgtttgc atcttccttc tctcaacgaa
     9301 tcatgtattt tatctaacca tgtcaggatc gtagtcataa aatcctgtat caaggaaacg
     9361 gtttttaggg tgaagtttac gaacttcttc atccagcaag aagacttgat catggctaaa
     9421 gttgccctct tgaatcaagt tacgcgcttg gataaagagt tttgcaatct caacaaagtt
     9481 ctgaccagga gtgtagagcc cttctagttt ccagcgagta aagccatgct ccaccaattc
     9541 tgttaatttg atcatcaaat caaggtcatt gttggcaaag atatgggtcc catgattatc
     9601 ttcaaaaatg gaatagtggc tctctggatc acttggctca gccaagaaga ggtcacgttt
     9661 atgcgtcttt tcatcatcga tatgtgtaaa gttatagtag ttttgcaaga gtggacgttt
     9721 agaatgatgg atgacgctag caccgtaaac caaaacttca gcaggaattt ccaaaatctc
     9781 tggcattttg aaaagttcag ctgatggaat ttcacgcgcc aaaacagcct cagatgcgcc
     9841 agccttttgt ccccagaagt taatctgacg actgctagtt accatggttg aagcatcgta
     9901 gatggtctta aatgaataac catcgcggtt aactacgtaa aagacgcctg catccccaat
     9961 cgtaatatag tctatcttga tttcttccaa gaagtctaag aaaggcttga tacggtccat
    10021 catatcttgg tgcataagag cattgaccgc aacgatcaat tccttaccag catcatgaac
    10081 caacttagcg atttcacgta attggtcata actaaaggtc gttggcagac gaaggccaaa
    10141 atctttctca ccgacataga tacggtctac gccagcttcg agtagttgtt caacttgttc
    10201 aatactttca gcagttgctg taatgacaat cttttccata agaaaaatta taccacattt
    10261 ctccaaaatc atccatgctt tgaaaatgaa aagggacttt attctttttg taacctttct
    10321 gtaataattc tctgccgaaa aaatgataaa ataggtatgt actgttaagg agagaattat
    10381 gcccgtaaga aaattacaat cctatgaggt agactatcaa gaagaattaa accagcagct
    10441 tcctcattac caagcttata cacctgaagc gcaatctgat gccaatctca aggaaatcct
    10501 attttttatt aatatcgctg ttttttgtat ctgcattgct atctttagtt ttatcttttt
    10561 agcattaaaa ttatcaactg ctcttgcctt tgccgcagca atcggattca gcttacttgt
    10621 tttaaaagtt caacggtcta ttatcaaacg aaaacgtaga agataaatcc aaaatatcgc
    10681 cccagttgga gcgatatttt tattttttct ttttagatgg tgtctgaatg gcaatcttca
    10741 cttcaaagat tgttcccttg ggtttattat ctttgacagt aacagttcct tttagagcat
    10801 ctacaatttg cttggctagg gataatccta aaccaaaacc acctttttgc cgggttctag
    10861 ctttgtctac tcgataaaaa cggtcaaaaa ttttcttttt atcttctgtc gaaataccga
    10921 ttccattatc agaaacaagt aaataaagat tgcgatcggt cgccgagata agaaaattaa
    10981 tttcaccatc ctcctcagta tacttgacgg cattatcgaa aagaatggtc atcagttgtt
    11041 tcagaagaag ctgatctgtg acaattgttc gatggatacg attttcaaaa cggaagacac
    11101 gattattttc cgaagcaatc atctcgtagt ttgtgaaagt tgtattaaaa aagctagttg
    11161 gaacttctgc aagctccggc ttaatcccat catctctccg agctaagttc agcaagcttg
    11221 tcgttaaaaa acgcatattt cggacttctt ccaaactcga tgcaatgctt tcgctcacat
    11281 ccataatggt agcttctggc ttacgaaaaa gggtctctaa gcgattttgc aaaactgcga
    11341 gtggagttcg taactcatga ctggcatttt ccacaaaaga ctgttgcttc tgcatactct
    11401 caagcagggg cctaacactg accctagcta gatagagact ggcaagtaaa gacaaaatcc
    11461 agaaactagc catcacgacc acaatcaatt gctcatgctt ttgactagcc tgctccaact
    11521 gactggtatt aatcaagaca gcagcatact tgatattggt tgaaaccgaa ctaatattgg
    11581 tctccatcaa aatcacacga tagatttctt cctgcccata gctattaaaa acctgaatct
    11641 ggtagatatg tcctagttct ttcttttcta acttaatctt atccaagccc aaaaatcgat
    11701 ttccagaaag aagttgagta aagtctttat caaagagaat gacttccgta ttggaactga
    11761 cattaggttt tatttctact ttactagcgt ccgccctagc attttctaaa tctttaatct
    11821 cttctgttgc cctatttata gccagctgaa taactgcttg aggattttca ctcagtccat
    11881 gaagcttatc gtccaccgaa gtataaagac tcgaatgcat gacttgtaaa ataatcagag
    11941 tcattgtaga aaaaatcagg gtgaagacac cgaagttgcg gataaaataa ctaaagtcat
    12001 ccgcatacca tgttttttta agtttactga acatctttta aaagataccc aacactacgc
    12061 aaggtttgca aattctctgc aaaagtggtt ccctttaatt tcttacggac ttttgaaaca
    12121 tagacttcga caaccgaaat cgttgtatca ctatcaaatc cccatagacg gtcaaaaatc
    12181 tgcgtcttag gcaaaatcac attttgattt tgaaggaaat aaactagtaa atcgaactct
    12241 ttccccagca attcgacagg agtatcttca actttaacgg tattggttga taaattaacc
    12301 acgatattcc cataagtcaa ggtgttttca ttaaacttcc ctgaacgttt gagaagggcc
    12361 tgaatccgca ttttaagttc ttctaggtag aaaggtttgg tcagataatc atccgctccc
    12421 agttcaaatc catgtccctt gtcatccaaa ctttccttgg cagtcataat cagaactggt
    12481 gtcgtaattc ccttttcacg caattctttt aagacttgga aaccattttt ttctggcaac
    12541 atcaaatcca gcaaaatcaa gtcatagaca ccactctcag cttcgtagag accttcttct
    12601 ccatcaaata cctgcataac atccgcaaaa tcgtctaaaa agtcaaatac tgaatttgac
    12661 agacctaggt catcctcaac caataagatt tttatcatga gaaactcctc cttattaaaa
    12721 ctattatacc aaatttgcct taaaaaaaac tcaactctct gcattttacg gctctataat
    12781 atttgtagtg ggtaaatcc
//
LOCUS       DAVLHC010000047        12740 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.048, whole genome shotgun sequence.
ACCESSION   DAVLHC010000047 DAVLHC010000000
VERSION     DAVLHC010000047.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 12740)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12740)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12740
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.048"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            270..1418
                     /locus_tag="VXE25_001692"
     CDS             270..1418
                     /locus_tag="VXE25_001692"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000636508.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDP-glycerol glycerophosphotransferase family
                     protein"
                     /protein_id="HEV0772120.1"
                     /translation="MVVLQNVKFLVRVVFMVIISIVLWPVRIKKNKILFINFNGKGYG
                     DNPKSICEYLRVTYPELDLVWLTKDNEDFPDGVRVVRYKSLQSFYEQASSKVWVYNVR
                     NFERLLKKRGQFYIQTWHGASSFKLIEQQADLPLKYILEAKYDARVTDIMISDSRKQT
                     EEFQKYFWYSGEIFEVGMPRNDALFHYKEDYDKLNNIRKKLSIDSDDYVILYAPTFRD
                     DGDASYLDINFERLLQSIEQEIKKKCKILIRLHPNDSHFSNNISFNHDIIDVTLFSDM
                     QELILLADVLLTDYSSAIFDFMLLNKPYVRYVNDLEKYAELRGVSDTYYELPDSIIKT
                     AEELYDLLPKKIENFDYDSIKKYRNEILCPIFNGTASENVGRRIIQEL"
     gene            1454..2482
                     /locus_tag="VXE25_001693"
     CDS             1454..2482
                     /locus_tag="VXE25_001693"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000794266.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-containing alcohol dehydrogenase family
                     protein"
                     /protein_id="HEV0772121.1"
                     /translation="MKNNDLKIGSGAIHQISATLSQNNISGKILYCADPVVDDLYGSI
                     VRSQIEEIGRVKEESCNYNTIAYAMNIAERAIATDIDCIVGMGGGRVLDVCKYASFIS
                     KRPYLSIPTTAANDGIASPVAVLKRQDDRPKSLGAAIPSMTLIDIDVIASGPIQNIKA
                     GIGDTISNYTALKDWELAVERGKDEMHGFAYLMSQNSLDALMKTKYNSITPDFIEVLV
                     NSLVLSGIAMDFAGSSRPVSGSEHLFSHALDYYGSTRNLHGIQVALGTVAVLKLIENS
                     VDTVVDYLQRFEVHINPKLLGIDEELFIYCMQHATKMRSNRYTYLHEVDLSTDRLKQI
                     YKELISEL"
     gene            2498..3202
                     /locus_tag="VXE25_001694"
     CDS             2498..3202
                     /locus_tag="VXE25_001694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000645462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphocholine cytidylyltransferase family
                     protein"
                     /protein_id="HEV0772122.1"
                     /translation="MKALILAAGLGTRLAPITNEVPKSLVPVNGKPILMKQIENLYQN
                     NITDITIIAGYKSSVLTDAVTEKYPEINIIDNVDFKTTNNMYSAYLGKAAMGDSDFLM
                     MNADVFYDASVIKSLLLHKAPNAIVTDLGIYIEESMKVVEKNGRLVEISKQISPEETL
                     GVSIDVYKFSYEAGARFFEKCKEFIEDKRELQMWSEVALNAILSEVEFVACPLEGRWL
                     EIDNHEDLVAAEKLFA"
     gene            3217..4050
                     /locus_tag="VXE25_001695"
     CDS             3217..4050
                     /locus_tag="VXE25_001695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000779205.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD-IIA family hydrolase"
                     /protein_id="HEV0772123.1"
                     /translation="MKLTNRVDYFGADISELQNKKLFLFDMDGTIYEEDRLFEGTLEL
                     LDYIHNIGGEYIFITNNSSKSVVDYVEKVNRLGIKAERDNFFTSAQATIVYIKENYPK
                     SKVYCQGTKSLIKELSDAGIDVTEQVSADIDVVLVGFDTELTSDKIRNTCEILSTKDI
                     PFIATNPDIRCPVSFGFIPDCGSICDMISKSVDRKPVYIGKPEPTMVDIVRKKLNYSL
                     FETVVIGDRLYTDIMTGINAGVTSVCVLTGEATVNDIQQGSIKPTYTFKNVKEMWKGI
                     V"
     gene            complement(4139..4531)
                     /locus_tag="VXE25_001696"
                     /pseudo
     CDS             complement(4139..4531)
                     /locus_tag="VXE25_001696"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            4850..6832
                     /locus_tag="VXE25_001697"
     CDS             4850..6832
                     /locus_tag="VXE25_001697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HEV0772124.1"
                     /translation="MKSSKLFALAGVTLLAATTLAACSGSGSSAKGEKTFSYIYETDP
                     DNLNYLTTAKAATANITSNVVDGLLENDRYGNFVPSMAEDWSVSKDGLTYTYIIRKDA
                     KWYTSEGEEYAAVKAQDFVTGLKYAADKKSDALYLVQESIKGLDAYVKGEIKDFSQVG
                     IKVLDEQTVQYTLNKPESFWNSKTTMGVLAPVNEEFLNSKGDDFAKATDPSSLLYNGP
                     YLLKSIVTKSSVEFAKNPNYWDKDNVHIDKVKLSFWDGQDTSKPAENFKDGSLTAARL
                     YPTSASFAELEKSMKDNIVYTQQDSITYLVGTNIDRQSYKYTSKTSDEQKASTKKALL
                     NKDFRQAIAFGFDRTAYASQLNGQTGASKILRNIFVPPTFVQADGKNFGDMVKEKLVT
                     YGDEWKDVNLADSQDGLYNPEKAKAEFAKAKSALQAEGVTFPIHLDMPVDQTATTKVQ
                     RVQSMKQSLEATLGADNVVIDIQQLQKDEVNNITYFAENAAGEDWDLSDNVGWGPDFA
                     DPSTYLDIIKPSVGESTKTYLGFDSGEDNVAAKKVGLYDYEKLVTEAGDETTDVAKRY
                     DKYAAAQAWLTDSALIIPTTSRTGRPILSKMVPFTIPFALSGNKGTSEPVLYKYLELQ
                     DKAVTVDEYQKAQEKWMKEKEESNKKAQEDLAKHVK"
     gene            7132..12435
                     /locus_tag="VXE25_001698"
     CDS             7132..12435
                     /locus_tag="VXE25_001698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001032503.1"
                     /note="The YSIRK form of extended signal peptide directs
                     nascent proteins to the cross-wall site, while signal
                     peptides lacking YSIRK direct proteins instead to the cell
                     pole. A large fraction of YSIRK proteins are surface
                     proteins anchored by sortase-mediated processing of a
                     C-terminal LPXTG motif; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YSIRK-type signal peptide-containing protein"
                     /protein_id="HEV0772125.1"
                     /translation="MNKGLFEKRCKYSIRKFSLGVASVMIGAAFFGTSPVLADSVQSG
                     STANLPADLATALATAKENDGRDFEAPKVGEDQGSPEVTDGPKTEEELLALEKEKPAE
                     EKPKEDKPAAAKPETPKTVTPEWQTVEKKEQQGTVTIREEKGVRYNQLSSTAQNDNAG
                     KPALFEKKGLTVDANGNATVDLTFKEDSEKGKSRFGVFLKFKDTKNNVFVGYDKDGWF
                     WEYKTPGNSTWYKGNRVAAPETGSINRLSITLKSDGQLNASNNDVNLFDTVTLPAAVN
                     DHLKNEKKILLKAGSYDDERTVVSVKTDNQEGVKTEDTPAEKETGPEVDDSKVTYDTI
                     QSKVLKAVIDQAFPRVKEYTLNGHTLPGQVQQFNQVFINNHRITPEVTYKKINETTAE
                     YLMKLRDDAHLINAEMTVRLQVVDNQLHFDVTKIVNHNQVTPGQKIDDERKLLSSISF
                     LGNALVSVSSDQTGAKFDGATMSNNTHVSGDDHIDVTNPMKDLAKGYMYGFVSTDKLA
                     AGVWSNSQNSYGGGSNDWTRLTAYKETVGNANYVGIHSSEWQWEKAYKGIVFPEYTKE
                     LPSAKVVITEDANADKKVDWQDGAIAYRSIMNNPQGWEKVKDITAYRIAMNFGSQAQN
                     PFLMTLDGIKKINLHTDGLGQGVLLKGYGSEGHDSGHLNYADIGKRIGGVEDFKTLIE
                     KAKKYGAHLGIHVNASETYPESKYFNEKILRKNPDGSYSYGWNWLDQGINIDAAYDLA
                     HGRLARWEDLKKKLGDGLDFIYVDVWGNGQSGDNGAWATHVLAKEINKQGWRFAIEWG
                     HGGEYDSTFHHWAADLTYGGYTNKGINSAITRFIRNHQKDAWVGDYRSYGGAANYPLL
                     GGYSMKDFEGWQGRSDYNGYVTNLFAHDVMTKYFQHFTVSKWENGTPVTMTDNGSTYK
                     WTPEMRVELVDADNNKVVVTRKSNDVNSPQYRERTVTLNGRVIQDGSAYLTPWNWDAN
                     GKKLSTDKEKMYYFNTQAGATTWTLPSDWAKSKVYLYKLTDQGKTEEQELTVKDGKIT
                     LDLLANQPYVLYRSKQTNPEMSWSEGMHIYDQGFNSGTLKHWTISGDASKAEIVKSQG
                     ANDMLRIQGNKEKVSLTQKLTGLKPNTKYAVYVGVDNRSNAKASITVNTGEKEVTTYT
                     NKSLALNYVKAYAHNTRRNNATVDDTSYFQNMYAFFTTGSDVSNVTLTLSREAGDEAT
                     YFDEIRTFENNSSMYGDKHDTGKGTFKQDFENVAQGIFPFVVGGVEGVEDNRTHLSEK
                     HDPYTQRGWNGKKVDDVIEGNWSLKTNGLVSRRNLVYQTIPQNFRFEAGKTYRVTFEY
                     EAGSDNTYAFVVGKGEFQSGRRGTQASNLEMHELPNTWTDSKKAKKATFLVTGAETGD
                     TWVGIYSTGNASNTRGDSGGNANFRGYNDFMMDNLQIEEITLTGKMLTENALKNYLPT
                     VAMTNYTKESMDALKEAVFNLSQADDDISVEEARAEIAKIEALKNALVQKKTALVADD
                     FASLTAPAQAQEGLANAFDGNLSSLWHTSWGGGDVGKPATMVLKEPTEITGLRYVPRG
                     SGSNGNLRDVKLVVTDESGKEHTFTATDWPDNNKPKDIDFGKTIKAKKIVLTGTKTYG
                     DGGDKYQSAAELIFTRPQVAETPLDLSGYEAALAKAQKLTDKDNQEEVASVQSSMKYA
                     TDNHLLTERMVEYFADYLNQLKDSATKPDAPTVEKPEFKLSSLASDQGKMPDYKQEIA
                     RPETPKQILPATGESQSDTALFLAGVSLALSALFVVKTKKD"
BASE COUNT         4233 a         2143 c         2666 g         3698 t
ORIGIN      
        1 tataagttct gtgctagcaa ccataatatt gatgattttc gcgattaaat cacctaaagc
       61 gattaatata aaaatactga atgaaattgg agataaatat gcgacttttg tttacattat
      121 acaccagttt atcattgtga tatttaaatt tttagtatct aatgtttata ttctcaaatt
      181 tgggacgata tttgtctttt tgatatgttg ttttctaggg gttctatttc aatttatcaa
      241 aaacagacta ttaaaaaggt ttagttaaga tggttgtttt acaaaatgtt aaatttttag
      301 taagagttgt ttttatggtt attatcagta tagtgttatg gcctgttcgg ataaagaaga
      361 ataagatact atttattaat tttaatggta agggatatgg tgataatccg aaaagtattt
      421 gtgagtatct tcgagttaca tatccagagt tagatttagt ttggcttaca aaagataatg
      481 aagattttcc agatggagtg agagttgtaa gatataaatc tctacaatct ttttatgagc
      541 aagctagttc gaaggtttgg gtttataatg taagaaattt tgaaagacta ctaaaaaaac
      601 gcggacagtt ttatattcaa acttggcacg gtgcttctag ttttaaactg atagaacagc
      661 aggctgattt accattaaaa tatattttag aagcaaagta tgatgcaaga gtcacagata
      721 taatgatttc agatagcaga aaacaaactg aagaatttca aaagtatttt tggtattcag
      781 gagaaatttt tgaggtgggg atgccgagaa atgatgcctt gtttcactat aaggaagact
      841 acgacaagtt aaataatatc agaaaaaaac taagcattga ttcagatgat tatgttattt
      901 tatatgcccc tactttcaga gatgatgggg atgcatctta tttagatata aattttgaac
      961 ggcttttgca aagtattgaa caagaaatta agaagaaatg taaaatttta attagattac
     1021 atcctaatga ctctcatttt agtaataata tttcttttaa tcatgacata attgatgtta
     1081 cgctattctc agatatgcag gaacttatat tattggcaga tgttttactg acagattatt
     1141 cttccgcgat atttgatttt atgcttttaa acaagcctta tgtcagatat gtgaatgatt
     1201 tagaaaaata tgctgagctt aggggggtat cagatacata ttatgaattg ccggattcta
     1261 ttattaaaac tgctgaagaa ttgtatgact tactgcctaa aaaaatagaa aattttgatt
     1321 atgattctat aaaaaaatat agaaatgaaa tactgtgtcc aatctttaat ggaaccgcta
     1381 gtgaaaatgt aggaaggaga ataattcaag agttgtgaag taaaacattg ggttattttt
     1441 aaggtaacga gatttgaaaa ataatgattt aaagatagga agtggagcta ttcatcaaat
     1501 ctccgctaca ctttctcaaa ataatatttc gggaaagatt ttatattgtg ctgatccagt
     1561 tgtcgatgac ttgtacggtt cgatagtacg ttcacaaata gaggaaattg gtcgggtaaa
     1621 ggaagaaagt tgcaattata atactattgc ttatgcgatg aatatagcag aaagggctat
     1681 tgccacagat attgactgta ttgtgggaat gggaggaggt cgtgttttag atgtctgcaa
     1741 gtatgcatct tttatttcga aacgtcctta cctatcgatt ccgacaacag cagcaaatga
     1801 tggcattgct tccccagttg ctgttttgaa aaggcaggat gatagaccaa aaagcttagg
     1861 ggcggctatc ccctcaatga cactaattga tattgatgtt attgcatcag gacctataca
     1921 aaatataaaa gctggtatcg gtgatacaat atccaattac actgcattga aagattggga
     1981 gttggcagtt gagcgaggga aagatgagat gcatggtttt gcatatctaa tgtcgcaaaa
     2041 ttctttagat gctttaatga aaacgaagta taattctatt acccctgatt ttattgaagt
     2101 tttggtaaac tctttagttt tatcaggcat tgcaatggat tttgcgggaa gtagtagacc
     2161 tgtcagtggg tcagagcact tatttagtca tgcattagat tactatggtt ctacaaggaa
     2221 tcttcatgga attcaggttg cattaggtac agtcgcagtt ttgaaattaa ttgaaaattc
     2281 tgttgatact gtagtggatt acttgcaaag atttgaggtt catattaacc cgaaactttt
     2341 ggggatagat gaagagttgt ttatttattg tatgcaacat gctacaaaaa tgagaagtaa
     2401 tcgctatacc tatctgcatg aagttgatct tagcacagat agattgaaac aaatatataa
     2461 ggaactcata agcgagttgt agaaaagaga ggaaaaaatg aaagcactta ttttagcagc
     2521 agggttagga acacgtctag ctccaattac caatgaggta ccaaaatctt tggtaccagt
     2581 caatggtaag ccaattttga tgaaacaaat tgaaaattta tatcaaaata atattacaga
     2641 tattacgatt attgctggat ataagtcatc tgtattaaca gatgcagtta ctgaaaagta
     2701 tccagaaatt aatattattg ataatgttga ttttaaaacg actaataata tgtattcagc
     2761 ctatctagga aaagctgcaa tgggtgatag tgacttctta atgatgaatg cagatgtatt
     2821 ttatgatgct tctgttatta aaagtctgtt gcttcataaa gctccaaatg caattgtaac
     2881 tgatttaggt atttatattg aagagtctat gaaagtcgta gaaaaaaatg gtcgtttagt
     2941 agaaatttct aaacagattt cacctgagga aactttagga gtttctattg atgtttataa
     3001 attctcttat gaagcaggtg ctcgattctt tgaaaagtgt aaggaattta ttgaagataa
     3061 acgagaactt caaatgtgga gtgaggttgc tcttaatgca attctttctg aagttgaatt
     3121 tgtagcatgt ccattagagg gtcgttggtt agaaattgat aatcatgaag acttagttgc
     3181 tgcagaaaaa ctatttgctt gaaccgaata cggagaatga aattgacaaa tagagttgat
     3241 tattttggtg ctgatattag tgaacttcag aataaaaaat tattcttatt tgatatggat
     3301 ggtaccattt atgaagaaga taggttgttt gagggtactc tcgaattatt agactatatt
     3361 cataatattg gcggtgagta tatttttatt acaaacaatt catctaagtc tgttgttgac
     3421 tatgtagaaa aagttaacag attaggtatt aaagctgaac gagataattt ttttacctct
     3481 gctcaagcca caattgttta tattaaagaa aattatccta aatctaaagt ttattgccaa
     3541 ggaacaaaat ctttgataaa agaactatct gacgcaggaa ttgatgtaac tgagcaagtt
     3601 agtgctgata tagatgttgt tcttgttggt tttgatacag aattaaccag tgataaaatt
     3661 cgcaatacct gcgagattct atcaacaaag gacatacctt tcatagctac taaccctgat
     3721 attcgctgcc cagtatcgtt tggattcatc ccagattgtg gttctatttg tgatatgatt
     3781 agtaaatcag tcgataggaa acctgtttac ataggtaaac ctgaacctac gatggttgat
     3841 attgttcgaa aaaaattaaa ttattctcta tttgaaacag ttgtgattgg agatcgcttg
     3901 tatacggata tcatgactgg tataaatgca ggagtaactt cagtttgtgt gctgacagga
     3961 gaagcaacgg tgaatgatat tcaacaaggt agtataaaac cgacttatac atttaaaaac
     4021 gtgaaagaaa tgtggaaagg aattgtctga ttttttcatt ctgaatagtg aattcatgaa
     4081 tactgtcaaa atactcgtat gtatttaaat tgattttatt attagacttc ctgcaaaact
     4141 agaatcctag ttcatgattg ataatagcag caatcaaatt cattcgtaat ccgaagcgtt
     4201 tacgatgatt tcgataggtt gttgaaaaca ttttaaacgt ttttactttg gcaaagatgt
     4261 tctcgacctt gcttctctcc ttggatagcg catggttata ggctttatct tcaactgtta
     4321 gcggcttgag tttgctggat ttacgtggag tttgtgcttg aggatatatc ttcatgagcc
     4381 cttgataacc actgtcagcc aagattttac cagcttgtcc gatatttctg cgactcattt
     4441 tgaacaactt catatcatga caatagttca cagtgatatc caaagaaaca attctccctt
     4501 gacttgtgac aatcgcctga gccttcatag cgagaaatat ctattctatc ttctagaatg
     4561 tcttccaaac gaggaaactc tcgtaaacaa agaggtttta gaggcttatt taccatggac
     4621 taaagttgta caagaaaagt gcaaataaga aatctccaga ttaggaacta tccgtgagtt
     4681 ctctagtctg gagatttttc aatatacttc gttattgggc gcttacaatg atattcatat
     4741 tttttgcaaa gatgttgttt gaaaaataat tttcaaaaat tctgaaaatt ctgttgacaa
     4801 ctttctgaaa agagtctata atggagagaa agttttaaag gagaaaatga tgaaaagttc
     4861 aaaactattt gcccttgcgg gcgtgacatt attggcggcg actactttag ctgcatgctc
     4921 tggatcaggt tcaagcgcta aaggtgagaa gacattctca tacatttatg agacagaccc
     4981 tgataacctc aactatttga caactgctaa ggctgcgaca gcaaatatta ccagtaacgt
     5041 ggttgatggt ttgctagaaa atgatcgcta cgggaacttt gtgccgtcta tggctgagga
     5101 ttggtctgta tccaaggatg gattgactta cacttatatt atccgtaagg atgcaaaatg
     5161 gtatacttct gaaggggaag aatacgcggc agtcaaagct caagactttg taacaggact
     5221 aaaatatgct gctgataaaa aatcagatgc tctttacctt gttcaagaat caatcaaagg
     5281 gttggatgcc tatgtaaaag gggaaatcaa agatttctca caagtaggaa ttaaggttct
     5341 ggatgaacag acagttcagt acactttgaa caaaccagaa agcttctgga attctaagac
     5401 aaccatgggt gtgcttgcgc cagttaatga agagtttttg aattcaaaag gagatgattt
     5461 tgccaaagct acggatccaa gtagtctctt gtataacggt ccttatttgt tgaaatccat
     5521 tgtgaccaaa tcctctgttg aatttgcgaa aaatccgaac tactgggata aggacaatgt
     5581 gcatattgac aaagttaaat tgtcattctg ggatggtcaa gataccagca aacctgcaga
     5641 aaactttaaa gatggtagcc ttacagcagc tcgtctctat ccaacaagtg caagtttcgc
     5701 agagcttgag aagagtatga aggacaatat tgtctatact caacaagact ctattacgta
     5761 tctagtcggt acaaatattg accgtcagtc ctataaatac acatctaaga ccagcgatga
     5821 acaaaaggca tcgactaaaa aggctctctt aaacaaggat ttccgtcagg ctattgcctt
     5881 tggttttgat cgtacagcct atgcctctca gttgaatgga caaactggag caagcaaaat
     5941 cttacgtaat atctttgttc caccaacatt tgttcaagca gatggtaaaa actttggcga
     6001 tatggtcaaa gagaaattgg tcacttatgg ggatgaatgg aaggatgtta atcttgcaga
     6061 ttctcaggat ggtctttaca atccagaaaa agccaaggct gaatttgcta aagctaaatc
     6121 agccttacaa gcagaaggtg tgactttccc aattcatttg gatatgccag ttgaccagac
     6181 agcaactaca aaagttcagc gcgtccaatc tatgaaacaa tccttggaag caactttagg
     6241 agcggataat gtagtcattg atattcaaca actacaaaaa gacgaagtaa acaatattac
     6301 atattttgct gaaaatgctg ctggcgaaga ctgggattta tcagataatg tcggttgggg
     6361 tccagacttt gccgatccat caacctacct tgatatcatc aaaccatctg taggagaaag
     6421 tactaaaaca tatttagggt ttgactcagg ggaagataat gtagctgcta aaaaagtagg
     6481 tctatatgac tacgaaaaat tggttactga ggctggtgat gagactacag atgttgctaa
     6541 acgctatgat aaatacgctg cagcccaagc ttggttgaca gatagtgctt tgattattcc
     6601 aactacatct cgtacagggc gtccaatctt gtctaagatg gtaccattta caataccatt
     6661 tgcattgtca ggaaataaag gtacaagtga accagtcttg tataaatact tggaacttca
     6721 agacaaggca gtcactgtag atgaatacca aaaagctcag gaaaaatgga tgaaagaaaa
     6781 agaagagtct aataaaaagg ctcaagaaga tctcgcaaaa catgtgaaat aactgttgca
     6841 aaatataaga aaggatttag tatttctctt gaatgctgaa tcctttttta catttgtaaa
     6901 gaaagattct aaatgtactg acccccaaaa gttggagcct ctttttgtca gaatagagaa
     6961 aatttttgtt aattttactt gtttcctatt gctttctcag ttattatttg ttatattaaa
     7021 agtataatta tttttattta tcagggttaa gcattgcact ttcagaggaa ggagtatttt
     7081 ttaaaaagaa aatgtaaacg cttgctcaaa aatgaaagga tttagaagtt tatgaataaa
     7141 ggattatttg aaaaacgttg taaatatagt attcggaaat tttcattagg tgttgcttct
     7201 gttatgattg gagctgcatt ctttgggaca agtccggttc ttgcagatag cgtgcagtct
     7261 ggttccacgg cgaacttacc agctgattta gctactgctc ttgcaacagc aaaagagaat
     7321 gatgggcgtg attttgaagc gcctaaggtg ggagaagacc aaggttctcc agaagttaca
     7381 gatggaccta agacagaaga agaactatta gcacttgaaa aagaaaaacc ggctgaagaa
     7441 aaaccaaaag aggataaacc tgcagctgct aaacctgaaa cgcctaagac ggtaacccct
     7501 gaatggcaaa cggtagagaa aaaagaacaa cagggaacag tcactatccg agaagaaaaa
     7561 ggtgtccgct acaaccaact atcctcaact gctcaaaatg ataacgcagg taaaccagct
     7621 ctgtttgaaa agaagggctt gaccgttgat gccaatggaa atgcaactgt tgatttaacc
     7681 ttcaaagaag attctgaaaa gggcaaatca cgctttggtg tcttcctgaa atttaaagat
     7741 accaagaaca atgtttttgt cggttatgac aaggatggtt ggttctggga atacaaaact
     7801 ccaggtaata gcacatggta taaaggcaac cgtgttgctg ctcctgaaac aggatcaata
     7861 aaccgtcttt ctatcactct caagtcagac ggtcagctaa atgccagcaa taacgatgtc
     7921 aatctctttg acacagtgac tctaccagct gcggtcaatg accatcttaa aaatgagaag
     7981 aagattcttc tcaaggcggg ctcttatgac gatgagcgaa cagttgttag cgttaaaacg
     8041 gataaccaag agggggtaaa aacagaggat acccctgctg aaaaagaaac aggtcctgaa
     8101 gttgatgata gcaaggtgac ttatgacacg attcagtcta aggtcctcaa agcagtgatt
     8161 gaccaagcct tccctcgtgt caaggaatac accttgaatg gacatacttt gccaggacag
     8221 gtgcaacagt tcaaccaagt ctttatcaat aaccaccgaa tcacccctga agtcacttat
     8281 aagaaaatca atgagacaac agcagagtac ttgatgaagc ttcgcgatga tgctcactta
     8341 atcaatgcgg aaatgacagt acgcttgcaa gttgtggaca atcaattgca ctttgatgtg
     8401 accaagattg tcaaccacaa tcaagtcact ccaggtcaaa agattgatga cgaaagaaaa
     8461 ctactttctt ctattagttt cctcggcaat gctttagtct ctgtttctag tgatcaaact
     8521 ggtgctaagt ttgatggggc aaccatgtca aacaatacgc atgtcagcgg agatgatcat
     8581 atcgatgtaa ccaatccaat gaaggatttg gctaagggtt acatgtatgg atttgtttct
     8641 acagataagc ttgctgctgg tgtttggagt aactctcaaa acagctatgg tggtggttcg
     8701 aatgactgga ctcgtttgac agcttataaa gaaacagtcg gaaatgccaa ctatgtagga
     8761 atccacagct ctgaatggca atgggaaaaa gcttataagg gcattgtttt cccagaatac
     8821 acgaaggaac ttccaagtgc taaggttgtt atcactgaag atgccaatgc agacaagaaa
     8881 gttgattggc aagatggtgc cattgcttat cgtagcatta tgaacaatcc tcaaggttgg
     8941 gaaaaagtta aggatatcac agcttaccgt atcgcgatga actttggttc tcaagcacaa
     9001 aacccattcc ttatgacctt ggatggtatc aagaaaatca atctccatac agatggtctt
     9061 gggcaaggtg ttctccttaa aggatatggt agcgaaggcc atgactctgg tcacttgaac
     9121 tatgctgata ttggtaagcg tatcggtggt gtcgaagact tcaagaccct aattgagaag
     9181 gctaagaaat atggagctca tctaggtatc cacgttaacg cttcagaaac ttatcctgag
     9241 tctaaatact tcaatgaaaa aattctccgt aagaatccag atggaagcta tagctatggt
     9301 tggaactggc tagatcaagg tatcaacatt gatgctgcct atgacctagc tcatggtcgt
     9361 ttggcacgtt gggaagattt gaagaaaaaa cttggtgacg gtctcgactt tatctatgtg
     9421 gacgtttggg gtaatggtca atcaggtgat aacggtgcct gggctaccca cgttcttgct
     9481 aaagaaatta acaaacaagg ctggcgcttt gcgatcgagt ggggccatgg tggtgagtac
     9541 gactctacct tccatcactg ggcagctgac ttgacctacg gtggctacac caataaaggt
     9601 atcaacagtg ccatcacccg ctttatacgt aaccaccaaa aagatgcttg ggtaggggac
     9661 tacagaagtt atggtggtgc agccaactat ccactgctag gtggctacag catgaaagac
     9721 tttgaaggct ggcaaggaag aagtgactac aatggctatg taactaactt atttgcccat
     9781 gacgtcatga ccaagtactt ccaacacttc actgtaagta aatgggaaaa tggtacaccg
     9841 gtgactatga ccgataacgg tagcacctat aaatggactc cagaaatgcg agtggaattg
     9901 gtagatgctg acaataataa agtagttgta actcgtaagt caaatgatgt caatagtcca
     9961 caatatcgcg aacgtacagt aactctcaac ggacgtgtca tccaagatgg ttcagcttac
    10021 ttgactcctt ggaactggga tgcaaatggt aagaaacttt ctactgataa ggaaaagatg
    10081 tactacttca atacgcaggc cggtgcaaca acttggaccc ttccaagcga ttgggcaaag
    10141 agcaaggttt acctttacaa gctaactgac caaggtaaga cagaagagca agaactaact
    10201 gtaaaagatg gtaaaattac cctagatctt ctagcaaatc aaccatacgt tctctatcgt
    10261 tcgaaacaaa ccaatcctga aatgtcatgg agtgaaggca tgcacatcta tgaccaagga
    10321 tttaacagtg gtaccttgaa acattggacc atttcaggcg atgcttctaa ggcagaaatt
    10381 gtcaagtctc aaggggcaaa cgatatgctt cgtattcaag gaaacaaaga aaaagttagt
    10441 ctcactcaga aattaactgg cttgaaacca aataccaagt atgccgttta tgtcggtgtc
    10501 gataaccgta gtaatgccaa ggcgagcatc actgtaaata ctggtgaaaa agaagtgact
    10561 acttatacca ataagtctct cgccctcaac tatgtaaaag cctatgccca caatacacgt
    10621 cgtaacaatg ctacagttga cgatacaagt tacttccaaa acatgtacgc cttctttaca
    10681 actggatcgg acgtatcaaa tgttactctg acattgagtc gtgaagctgg tgatgaagca
    10741 acttactttg atgaaattcg tacctttgaa aacaattcaa gcatgtacgg agacaagcat
    10801 gatacaggta aaggcacctt caagcaagac tttgaaaatg ttgctcaggg tatcttccca
    10861 tttgtagtgg gtggtgtcga aggtgtcgaa gacaaccgca ctcacttgtc tgaaaaacac
    10921 gatccatata cacaacgtgg ttggaatggt aagaaagtcg atgatgttat cgaaggaaat
    10981 tggtcactca agacaaatgg actagtgagc cgtcgtaact tggtttacca aaccatccca
    11041 caaaacttcc gttttgaagc aggtaagacc taccgtgtaa cctttgaata cgaagcaggt
    11101 tcagacaata cctatgcttt tgtagtcggt aagggagaat tccagtcagg tcgtcgtggt
    11161 actcaagcaa gcaacttgga aatgcatgaa ttgccaaata cttggacaga ttctaagaaa
    11221 gccaagaagg caaccttcct cgtgacaggt gcagaaacag gggatacttg ggtaggtatc
    11281 tactcaactg gaaatgcaag taatactcgt ggtgattctg gtggaaatgc caacttccgt
    11341 ggttataacg acttcatgat ggataatctt caaatcgaag aaattaccct aacaggtaag
    11401 atgttgacag aaaatgctct gaagaactac ttgccaacgg ttgccatgac taactacacc
    11461 aaagagtcta tggatgcttt gaaagaggcg gtctttaacc tcagtcaggc cgatgatgat
    11521 atcagtgtgg aagaagcgcg tgcagagatt gccaagattg aagccttgaa gaatgctttg
    11581 gttcagaaga aaacggcttt ggtagcagat gactttgcaa gtcttacagc tcctgctcag
    11641 gctcaagaag gtcttgcaaa tgcctttgat ggaaacttat ctagtttatg gcatacatca
    11701 tggggcggag gagatgtagg caagcctgca accatggtct tgaaagaacc aactgaaata
    11761 actggacttc gttatgttcc acgtggatca ggttcaaatg gtaacttgcg tgatgtgaaa
    11821 cttgttgtga cagatgagtc tggcaaggag cataccttta ctgcaactga ttggccagat
    11881 aacaataagc caaaagacat tgactttggt aagacaatta aggctaagaa aattgtcctt
    11941 acaggtacta agacttacgg agatggtggc gataaatacc aatctgcagc ggaacttatc
    12001 tttactcgtc cacaggtagc agaaacacct cttgacttgt caggctatga agcagctttg
    12061 gctaaggctc agaaattaac agacaaagac aatcaagagg aagtagctag cgttcagtca
    12121 agcatgaaat atgcgacgga taaccatctc ttgacggaaa gaatggtgga atactttgca
    12181 gattatctca accaattaaa agattctgct acgaaaccag atgctccaac tgtagagaaa
    12241 cctgagttta aacttagctc tttagcttcc gatcaaggta agatgccaga ttataagcaa
    12301 gaaatagcta gaccagaaac acctaaacaa atcttgccag caacaggtga gagtcaatct
    12361 gacacagccc tcttcctagc aggtgttagc ctagccctat ctgctctctt tgtagtaaaa
    12421 acgaagaaag actagtattt agtaaaacat cttaacaaga ttacggaagc agtctctatc
    12481 ttttccaatg aggtttatag tacagaaaaa gcctgagaag atgtcttctc aggcttttgt
    12541 taagcacata aatacaatag tgctatgaaa aaatcaccca gaaaaatggc tctataatat
    12601 ttgtagtggg taaatccact atagatatta tggagcctat tttattgtag aaaaaaagtc
    12661 ccataagatc tataatgaaa agcgaccaaa caactcatta gaaagattca tatggaacaa
    12721 ttacatttta tcacaaaact
//
LOCUS       DAVLHC010000048        12663 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.049, whole genome shotgun sequence.
ACCESSION   DAVLHC010000048 DAVLHC010000000
VERSION     DAVLHC010000048.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 12663)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12663)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12663
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.049"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..558
                     /locus_tag="VXE25_001699"
     CDS             <1..558
                     /locus_tag="VXE25_001699"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436393.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEV0772126.1"
                     /translation="LDRFHIVQHLSRAMSRVRVQIMNQLDRKSHEYKAIKRYWKLIQQ
                     DSRKLSDKRFYRPTFRMHLTNKEILDKLLSYSQNLKHHYQLLLFHFQNKEPEKLFGLI
                     EDNLKQVHPIFQTVFKTFFKDKEKIINALQLHYSNAKLEATNNLIKLIKRNAFGFRNF
                     ENFKKRIFIALNIKKERTKFVLSRA"
     gene            complement(642..1844)
                     /gene="rpsA"
                     /locus_tag="VXE25_001700"
     CDS             complement(642..1844)
                     /gene="rpsA"
                     /locus_tag="VXE25_001700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002897515.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S1"
                     /protein_id="HEV0772127.1"
                     /translation="MNEFEDLLNSVSQVETGDVVSAEVLTVDATQANVAISGTGVEGV
                     LTLRELTNDRDADINDFVKVGEVLDVLVLRQVVGKDTDTVTYLVSKKRLEARKAWDKL
                     VGREEEVVTVKGTRAVKGGLSVEFEGVRGFIPASMLDTRFVRNAERFVGQEFDTKIKE
                     VNAKENRFILSRREVVEAATAAARAEVFGKLAVGDVVTGKVARITSFGAFIDLGGVDG
                     LVHLTELSHERNVSPKSVVTVGEEIEVKILDLNEEEGRVSLSLKATVPGPWDGVEQKL
                     AKGDVVEGTVKRLTDFGAFVEVLPGIDGLVHVSQISHKRIENPKEALKVGQEVQVKVL
                     EVNADAERVSLSIKALEERPAQEEGQKEEKRAARPRRPRRQEKRDFELPETQTGFSMA
                     DLFGDIEL"
     gene            complement(2006..2077)
                     /locus_tag="VXE25_001701"
     tRNA            complement(2006..2077)
                     /locus_tag="VXE25_001701"
                     /product="tRNA-Gln"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(2043..2045),aa:Gln,seq:ttg)
     gene            complement(2087..2167)
                     /locus_tag="VXE25_001702"
     tRNA            complement(2087..2167)
                     /locus_tag="VXE25_001702"
                     /product="tRNA-Tyr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(2131..2133),aa:Tyr,seq:gta)
     gene            complement(2217..2447)
                     /locus_tag="VXE25_001703"
     CDS             complement(2217..2447)
                     /locus_tag="VXE25_001703"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000037109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2969 domain-containing protein"
                     /protein_id="HEV0772128.1"
                     /translation="MSKKDKKIEIQVADAKVNVGKDSFEGYTLTIGKKVIGEIAELDG
                     QFAIIKNGNVDSFYKKLEKAVEILIENYNLAK"
     gene            complement(2615..3259)
                     /gene="pcp"
                     /locus_tag="VXE25_001704"
     CDS             complement(2615..3259)
                     /gene="pcp"
                     /locus_tag="VXE25_001704"
                     /EC_number="3.4.19.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyroglutamyl-peptidase I"
                     /protein_id="HEV0772129.1"
                     /translation="MKILVTGFNPFGGEKINPALEAVKLLPSEINGAEVRWVEIPTVF
                     YKSSEVLEAEILRYQPDAVLCIGQAGGRTGLTPERVAINQDDARIPDNEGNQPIDTPI
                     RIDGASAYFSSLPIKAMVQAIKKQGLPAVVSNSAGTFVCNHLMYQALYLVDKKFPNMR
                     AGFMHIPYMMEQVVNKPNTAGMSLCDIVRGIEVAIEAIVDYKDKDLQLVGGETH"
     gene            complement(3274..4197)
                     /locus_tag="VXE25_001705"
     CDS             complement(3274..4197)
                     /locus_tag="VXE25_001705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000137271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF979 domain-containing protein"
                     /protein_id="HEV0772130.1"
                     /translation="MTELAKQLLELTYIVIGCQFLHTAYCSYKDKTNPVRLGTSAFWT
                     LLSITFIGGSYMPNMSIGIIVILLSLLTLFKQVRIGTLPSLDEMKANIESNRLKNKIF
                     IPVMLMAILALVLAQMIPEFSKISISLAALFATISVLVITNSHPKSLLSENNRMTQQV
                     STSGIVPQLLGALGAIFTVAGVGDVISHLISGIVPSDSRFIGVLAYVLGMVLFTMIMG
                     NAFAAFTVITAGVGVPFVFALGANPIVAGALAMTAGYCGTLLTPMAANFNALPAALMD
                     MKDQNGVIKAQAGVALVMIVIHIFLMYFLAF"
     gene            complement(4194..4883)
                     /locus_tag="VXE25_001706"
     CDS             complement(4194..4883)
                     /locus_tag="VXE25_001706"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000454813.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF969 domain-containing protein"
                     /protein_id="HEV0772131.1"
                     /translation="MEWIRLIGIAIIVVGFILKFDTIATVVLAGLVTALVSGVSLVEF
                     LEILGKEFSNQRVLTIFMVTLPLVGLSETFGLKQRSIDLIRKIKGLTVGNFYTVYFFI
                     RELAGFFSIRLGGHPQFVRPLVQPMGEAAAESQLGRKLTEVEDETIKARAAANENFGN
                     FFAQNTFVGAGGVLLIGGTLDQLGYESNYAGIASTSIIVAVITLIVVGIYNYLFDKKL
                     ISKKTRGGEQK"
     gene            complement(4948..5652)
                     /locus_tag="VXE25_001707"
     CDS             complement(4948..5652)
                     /locus_tag="VXE25_001707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HEV0772132.1"
                     /translation="MVLSTSAILVACGKTDKEADAPTTFSYVYAVDPASLGYSIATRT
                     STTDVIGNVIDGLMENDKCGNVAPSQKDYDLNSTGWAPSYQDPASYLNIIDPKSGSAM
                     KHLGITKGKDKDVVAKPGLDKYKKLLEDAVSETTDLEKRYEKYAKAQAWSTDSSLLMP
                     TASSGGSPVVSNVVPFSKPYSQVGIKGDPYIFKGMKLQKDILTTKEYNEVFKKWQKEK
                     LESNSKYQKELEKHIK"
     gene            complement(5708..6730)
                     /locus_tag="VXE25_001708"
     CDS             complement(5708..6730)
                     /locus_tag="VXE25_001708"
                     /EC_number="2.6.1.42"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid aminotransferase"
                     /protein_id="HEV0772133.1"
                     /translation="MTVTIDWENLGFSYMKLPYRYLAHFKNGQWDQGELTEDATLHIS
                     ESSPSLHYGQQAFEGLKAYRTKDGSVQLFRPDENAKRLQRTCDRLLMPQVPTDMFVEA
                     CKAVVRANEEYVPPYGIGGTLYLRPLLIGVGDIIGVKPAEEYIFTIFAMPVGNYFKGG
                     LVPTNFLIQDEYDRAAPNGTGAAKVGGNYAASLLPGKMAKSRHFSDVIYLDPSTHTKI
                     EEVGSANFFGITADNEFVTPLSPSILPSITKYSLLYLAEHRLGLTPIEGDVPIDNLDR
                     FVEAGACGTAAVISPIGGIQHGDDFHVFYSETEVGPVTRKLYNELTGIQFGDIEAPEG
                     WIVKVD"
     gene            complement(6862..9333)
                     /gene="parC"
                     /locus_tag="VXE25_001709"
     CDS             complement(6862..9333)
                     /gene="parC"
                     /locus_tag="VXE25_001709"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase IV subunit A"
                     /protein_id="HEV0772134.1"
                     /translation="MSNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRI
                     LYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMH
                     GNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKNTVPFAWNFDDTEKEPTVLPAAFP
                     NLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAI
                     IQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVR
                     VNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDN
                     FTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALI
                     RASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLA
                     AIIGDERTMYNLMKKELREVKKKFATPRLSSLEDTAKAIEIDTASLIAEEDTYVSVTK
                     AGYIKRTSPRSFAASTLEEIGKRDDDRLIFVQSAKTTQHLLMFTSLGNVIYRPIHELA
                     DIRWKDIGEHLSQTITNFETNEEILYVEVLDQFDDATTYFAATRLGQIKRVERKEFTP
                     WRTYRSKSVKYAKLKDDTDQIVAVAPIKLDDVVLVSQNGYALRFNIEEVPVVGAKAAG
                     VKAMNLKEDDVLQSGFICNTSSFYLLTQRGSLKRVSIEEILATSRAKRGLQVLRELKN
                     KPHRVFLAGAVAEQGFVGDFFSTEVDVNDQTLLVQSNKGTIYESRLQDLNLSERTSNG
                     SFISDTISDEEVFDAYLQEVVTEDK"
     gene            complement(9753..11696)
                     /gene="parE"
                     /locus_tag="VXE25_001710"
     CDS             complement(9753..11696)
                     /gene="parE"
                     /locus_tag="VXE25_001710"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522163.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase IV subunit B"
                     /protein_id="HEV0772135.1"
                     /translation="MSKKEININNYNDDAIQVLEGLDAVRKRPGMYIGSTDGAGLHHL
                     VWEIVDNAVDEALSGFGDRIDVTINKDGSLTVQDHGRGMPTGMHAMGIPTVEVIFTIL
                     HAGGKFGQGGYKTSGGLHGVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLK
                     KIGTAPKSKTGTKVTFMPDATIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDE
                     AIEFHYENGVQDFVSYLNEDKEILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVN
                     NVRTKDGGTHETGLKSAITKVMNDYARKTGLLKEKDKNLEGSDYREGLAAVLSILVPE
                     EHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLMENGELASNLIRKAIKARDAREAA
                     RKARDESRNGKKNKKDKGLLSGKLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQ
                     AILPLRGKVVNTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDAD
                     TDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKKEEVAYAWTDGELEE
                     LRKQFGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGD
                     KVEPRRKWIEDNVKFTLEEATVF"
     gene            11832..12473
                     /gene="plsY"
                     /locus_tag="VXE25_001711"
     CDS             11832..12473
                     /gene="plsY"
                     /locus_tag="VXE25_001711"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000628793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol-3-phosphate 1-O-acyltransferase PlsY"
                     /protein_id="HEV0772136.1"
                     /translation="MITIVLLILAYLLGSIPSGLWIGQVFFQINLREHGSGNTGTTNT
                     FRILGKKAGMATFVIDFFKGTLATLLPIIFHLQGVSPLIFGLLAVIGHTFPIFAGFKG
                     GKAVATSAGVIFGFAPIFCLYLAIIFFGALYLGSMISLSSVTASIAAVIGVLLFPLFG
                     FILSNYDSLFIAIILALASLIIIRHKDNIARIKNKTENLVPWGLNLTHQDPKK"
     gene            complement(12507..>12663)
                     /locus_tag="VXE25_001712"
     CDS             complement(12507..>12663)
                     /locus_tag="VXE25_001712"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436265.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEV0772137.1"
                     /translation="YSNAKLEATNNLIKLIKRNAFGFRNFENFKKRIFIALNIKKERT
                     KFVLSQA"
BASE COUNT         3664 a         2847 c         2233 g         3919 t
ORIGIN      
        1 ttggatcgct ttcacattgt acaacatctt agccgtgcta tgagtcgtgt gcgtgtccaa
       61 atcatgaatc aattggatcg aaaatcccat gaatacaagg ctatcaagcg ctactggaaa
      121 ctcattcaac aggatagccg taaactgagt gataagcgat tttatcgtcc tacttttcgt
      181 atgcacttaa ccaataaaga gattttagac aagcttttga gctattcaca aaacttgaaa
      241 caccactatc agctcttgct ttttcacttc cagaataagg aaccagagaa acttttcgga
      301 cttattgagg acaatctgaa gcaggttcat cctatttttc agactgtctt taaaaccttc
      361 ttcaaagata aggaaaagat tatcaacgcc cttcaactac actattctaa tgccaaactg
      421 gaagcgacca ataatctcat caaacttatc aagcgcaatg cctttggttt tcgaaacttt
      481 gaaaatttca aaaaacggat ttttatcgct ttgaacatca aaaaagaaag gacgaaattt
      541 gtcctttctc gagcttagct tttttcaacc cactacagtt gacaaagagc cgaaaaatcc
      601 cttgtttagt aaacaaagga ttttgtgaat tttcaatttg attaaagttc gatatcacca
      661 aacaaatcag ccattgaaaa tcctgtttgt gtttctggaa gttcgaaatc acgcttttct
      721 tgacgtcttg gacgacgtgg acgagcagca cgtttttctt ctttttgtcc ttcttcttgg
      781 gctggacgtt cttcaagagc tttaatagaa agtgatacgc gttctgcatc tgcgttaact
      841 tcaagaactt taacttgaac ttcttgacca actttaagag cttcttttgg attttcaatc
      901 cgtttgtgtg aaatttgtga tacgtgaaca agtccatcga tacctggcaa tacttcaaca
      961 aatgcaccga agtcagtcaa acgtttaact gttccttcta ctacatcacc tttagccaat
     1021 ttttgctcaa cgccatccca tggtcctggt actgttgctt taagtgaaag tgatacacgt
     1081 ccttcttctt cgttaagatc aaggattttc acttcaattt cttcaccaac agttacaact
     1141 gattttggtg atacgttacg ttcatgtgac aattcagtca agtgaaccaa tccgtcaaca
     1201 ccaccaaggt cgatgaaagc gccgaagctt gtgatacgag caactttacc agttacaaca
     1261 tcaccaacag ccaatttacc gaatacttca gcgcgagctg ctgcagtagc tgcttcaaca
     1321 acttcacgac gtgaaaggat gaagcggttt tctttagcgt taacttcttt gattttagta
     1381 tcaaattctt gacctacaaa acgctcagcg ttacgtacga aacgagtatc caacattgaa
     1441 gctgggataa atccacgaac accttcaaat tctactgaaa gtccaccttt aacggcacgc
     1501 gttcctttaa cagtaacaac ttcttcttcg cgaccaacaa gtttgtccca tgctttgcga
     1561 gcttcaaggc gttttttaga tacaaggtat gtaactgtat cagtatcttt accaactact
     1621 tgacgaagta caagaacatc caatacttct cctactttaa caaagtcatt gatatctgca
     1681 tcacgatcgt ttgtcaattc gcgaagagtc aagacacctt caacaccagt tccagagatt
     1741 gcaacgttag cttgagtcgc atcaactgtc aatacttcag cactaacaac atcaccagtc
     1801 tcaacttgac taacgctatt tagcaaatct tcaaattcgt tcatctaaaa aatcctccaa
     1861 caatcaagtt tttcttaaac ttgacatact tataattttt ttcctaagca cccgcaagga
     1921 catgttcata tcattcacgt ctttcaatta taaaaataaa ataccctaag atattttgct
     1981 ttttatcttg attattacct aagaactggg gtagctggat tcgaaccaac gcatgaggga
     2041 gtcaaagtcc cttgccttac cgcttggcta taccccatta atgaaatgga gagagaggga
     2101 ttcgaacccc cgaacccgaa ggagcggatt tacagtccgc cgcgtttagc ctcttcgcta
     2161 tctctcctac aatcaacatg gactattata tcatgaaaat ttcaaaaaaa caagacttat
     2221 tttgctaaat tataattttc aatcaaaatt tccacagctt tttccaattt tttataaaaa
     2281 ctatcgacat tcccattctt tataatggca aattgtccgt ctaattcggc aatttctccg
     2341 ataacttttt taccgatagt caatgtataa ccttcaaaac tgtctttacc aacattaact
     2401 ttggcatccg ctacttgaat ttcgattttt ttatctttct tgctcatttc atacctctct
     2461 tcactttttc tattttacaa gaaaatccta aaactagcaa gaaaaaactc tatatcaggc
     2521 ttctctgata tagagtttta tgtaaacaac ctcaatcgat ttagcatagc taatagttag
     2581 taaacaagca taattgacta tcctttctag gttatcagtg agtctcaccg cctactaact
     2641 gcaaatcctt atctttgtag tctacaatag cttcaatagc tacctctatg cctcttacaa
     2701 tatcacatag actcattcct gcagtattcg gcttatttac tacttgttcc atcatatatg
     2761 gaatatgcat gaaacctgct ctcatattag ggaatttttt atccactaaa taaagagctt
     2821 ggtacatcaa atgattgcaa acaaaggttc ctgcactatt ggatacaact gccggaagtc
     2881 cctgtttttt gatagcttgt accatcgctt tgataggtaa actactaaaa taggccgatg
     2941 ctccatcaat acgaatcggt gtatcaattg gttgattgcc ttcgttatca ggtatgcgag
     3001 catcatcttg attaatagcc actcgttcag gtgttaagcc ggtcctgccg cctgcttgtc
     3061 caatacaaag tacagcatct ggttgatatc gtaatatttc tgcctctaaa acttctgacg
     3121 acttataaaa aaccgttgga atttctaccc agcgaacttc agccccatta atctcagatg
     3181 gtaataattt tacagcctcc aaagctggat taatcttttc acctccaaaa ggattaaaac
     3241 ctgtaaccaa tattttcatt ttattttcct ttactaaaat gcgagaaagt acattaagaa
     3301 tatgtgaata acaatcatta ctagagcaac acctgcttga gcctttataa cgccattctg
     3361 atctttcata tccatcaatg ctgctggtag agcgttaaaa ttagcagcca ttggggtcaa
     3421 taaggtccca caataacctg ctgtcatggc aagagcacca gccacaattg gattagctcc
     3481 cagagcaaat acaaagggaa ctccaacacc tgctgtaata acggtgaatg ctgcaaaagc
     3541 atttcccata atcattgtga atagaaccat tccaagaaca taggccaaaa ctcctataaa
     3601 gcgactatct gaaggaacaa taccgctaat cagatgagag ataacatcac caacacctgc
     3661 tacagtaaaa atagccccca aagcccctaa taattgagga acaataccac ttgttgaaac
     3721 ttgctgagtc attcgattat tttctgataa cagactctta gggtgactat tggtaatcac
     3781 aagaacagaa attgtagcaa acaaggcggc aaggctaatc gaaatcttgc taaattctgg
     3841 aatcatttgc gctaagacca acgcaagtat tgccatcagc ataactggaa taaaaatttt
     3901 atttttcaac ctgttagatt caatattggc tttcatttca tctaaggatg gcaaggttcc
     3961 gatacggact tgcttaaaca atgttaacag cgataatagg attacaataa taccaatact
     4021 catatttggc atataggaac cacctataaa cgtaatagac aatagagtcc aaaatgcaga
     4081 tgtcccaagt cgaactgggt ttgttttatc tttataacta caataggctg tatggagaaa
     4141 ttgacaacca atcacaatat aggtcaactc taatagttgc tttgccaact ctgtcatttt
     4201 tgttctcctc ccctagtctt ttttgatatc aattttttat caaataaata attgtaaatc
     4261 cccactacaa taagtgttat aacagcaaca ataatagatg tagaagcaat ccctgcataa
     4321 ttgctttcat agcctaactg atctaatgtt ccccctatca agaggactcc cccagcacct
     4381 acaaacgtat tttgagcaaa gaaatttcca aaattttcat tcgcagccgc acgcgctttt
     4441 attgtctcat cttcaacctc tgttaacttt ctacctaatt gagactctgc agctgcttct
     4501 cccataggtt gaaccaaagg tctgacaaac tgagggtgtc ctcctagacg aattgaaaag
     4561 aaaccagcta actctcgaat aaagaaataa actgtataga agtttccaac tgtcagacct
     4621 ttaatctttc gaatcaaatc gattgatcgt tgcttgagtc caaaggtttc tgacagcccc
     4681 acaagaggca aggtaaccat aaaaatcgtg agcactcgct gattgctaaa ttcttttccc
     4741 aaaatctcca aaaattcaac gagagaaaca cctgaaacta aagctgtaac caaaccagct
     4801 aagactactg ttgcaattgt atcaaatttt aaaataaaac ccacaacaat gattgctatt
     4861 cctattaatc taatccactc catatcaaac tcctttatat tcaaaatgac agtattttta
     4921 aaattttatc aagatcaata ccattcctta tttaatgtgt ttttctagtt ctttttggta
     4981 tttgctattg gattccaatt tttctttttg ccatttttta aaaacctcgt tatattcttt
     5041 tgttgtaaga atatcttttt gcaatttcat tcctttaaag atatatggat cccccttaat
     5101 accaacttgt gagtatggtt ttgagaatgg tactacgtta cttacaactg gagaaccacc
     5161 agatgaagct gttggcatca ataatgaact atctgtcgac caagcttgag ctttggcata
     5221 tttttcatat cttttctcta ggtcagtggt ctcagaaaca gcatcttcta acaatttctt
     5281 atatttatcc aaaccaggtt tagctacaac atccttatct tttcctttcg taataccaag
     5341 gtgtttcatg gcagaaccag attttggatc tataatattc aagtaagacg ctggatcttg
     5401 atagcttgga gcccatcctg tactattcaa atcatagtct ttttgagaag gagcaacatt
     5461 gccgcattta tcattttcca tcaaaccatc aataacattt ccaataacgt ctgtcgtcga
     5521 tgttcgagtc gctatactgt agcccaatga tgctggatct actgcataga cataagaaaa
     5581 tgttgtcggt gcatctgctt ctttatcagt ttttccacaa gccactaaaa tagctgacgt
     5641 gctcaggacc actcctgctg ttaagagcca ctttttctat ttcataaaaa atctcctttg
     5701 gtttatttta atctactttt acaatccaac cttctggcgc ttcaatatcg ccaaactgaa
     5761 tacccgtcaa ttcattatat aatttacgcg tcacaggacc tacttctgtt tcactataga
     5821 atacatggaa atcatcacca tgttgaatac ctccaattgg agaaataacc gctgctgtac
     5881 cacaggcacc tgcctctaca aaacggtcaa gattatcaat tggaacatca ccctcaatag
     5941 gagttaatcc caagcgatgt tctgccaaat aaagcaagga atacttggta atagatggca
     6001 agatagatgg actcaatggt gttacaaatt cattatcagc tgtaattcca aagaagttag
     6061 ctgatccgac ttcttcaatc tttgtatgag ttgatgggtc cagatagata acatctgaga
     6121 aatgacgtga cttggccatt tttcctggta agagacttgc agcatagttt ccaccaacct
     6181 tagccgcacc tgtaccattt ggtgctgcac ggtcgtactc atcctgaatc aagaagttgg
     6241 ttgggaccaa accaccttta aagtaatttc caactggcat agcaaagatg gtgaaaatgt
     6301 attcttctgc cggttttacc ccgataatat ctccgacacc aatcaaaaga gggcgaagat
     6361 ataaggttcc acctattccg tatggtggta cgtattcttc attcgcacgg acaactgctt
     6421 tacaagcttc tacaaacatg tctgtcggaa cttgtggcat caagagacgg tcacatgtac
     6481 gttgcaggcg tttagcattt tcatcaggac ggaacagttg aacactgcca tccttagtac
     6541 gataagcttt caaaccttca aatgcttgtt gtccatagtg aagacttgga gaagactctg
     6601 aaatatgcaa agttgcatcc tctgtaagct ctccttgatc ccattgtcca tttttgaaat
     6661 gagcaagata gcgataaggt aatttcatat aggaaaaacc gaggttttcc caatcaatcg
     6721 ttactgtcat attccactcc ttattctaaa aacctatttc ttatattcta cactattttt
     6781 ctaaaatagc aagtatattt tgtaattttc agaaaatttc tccaataaaa accagctctt
     6841 agaactgatt cttcatttca cttatttatc ttcagtaact acttcctgaa gataagcgtc
     6901 aaaaacttct tcatctgaaa tcgtgtcaga aatgaagctt ccattgctag tgcgttctga
     6961 caagttcaag tcttgcaatc ggctttcata gattgttcct ttattggatt ggacaagcag
     7021 agtttggtcg ttcacatcca cttccgtact gaagaaatcg ccaacaaatc cttgctctgc
     7081 aactgctcct gccaagaaga cacgatgcgg tttgtttttc aactcacgca agacttgtaa
     7141 tcctcgtttg gcacggctgg ttgctagaat ttcctcaatg gaaacacgtt tcaagcttcc
     7201 acgctgggtc aagaggtaga aggacgaagt attacagata aagccagatt ggaggacatc
     7261 atcttctttc aaattcatag ccttgacacc tgctgcctta gcaccgacaa ccggaacctc
     7321 ttcgatattg aaacgcaggg cataaccatt ttgactaacc aagacaacat catctagttt
     7381 aatcggagcc actgctacaa tctgatctgt atcgtctttg agcttagcat acttgacaga
     7441 cttagatcta taggtccgcc atggagtaaa ttcttttcgc tctacccgtt tgatttgacc
     7501 aaggcgagtc gctgcaaagt aggttgtcgc atcgtcaaac tgatccagta cttccacata
     7561 aagaatttct tcattcgttt caaagtttgt gatggtttgg ctcagatgct ctccgatgtc
     7621 cttccaacga atatctgcca actcatggat tggtctgtag atgacatttc caagacttgt
     7681 gaacatcaag aggtgctggg ttgtcttggc agattgaaca aaaatcaaac ggtcatcatc
     7741 acgcttgcca atttcttcca aggtggaagc cgcaaaggaa cgtggactgg tacgcttgat
     7801 gtaacctgcc ttggtcacgc tgacgtaggt atcttcctca gcgataagac tagctgtatc
     7861 aatctcaatt gctttcgcag tatcttctaa agaactcaaa cgaggagttg caaatttctt
     7921 cttgacctca cgaagttctt tcttcatgag attgtacata gtcctttcat caccgataat
     7981 agccgccagc atagcaatct tctcacgaag ctctgcttct tcttcctgca agacaaccac
     8041 atcggtattg gtcaaacggt acagttgcaa agttacgata gcctcagcct gttcttccgt
     8101 aaaatcatag ctaactttga ggttttcctt ggcgtccgcc ttattctcag aagcacggat
     8161 aagagcaatg acttcatcca aaatcgaaat cacacgaatc aaaccttcga cgatatggag
     8221 acgtttctca gccttttctt tgtcaaagcg tgaacgcgcc aaaatcactt ctcgacggtg
     8281 agcgatgtag ctagacagga ttggaacaat cccaacctga cgaggtgtga aattgtcaat
     8341 cgccaccata ttaaagttgt agttgatttg taggtcggtg tacttaaata agtagttgag
     8401 aacaagctca gtattagcgt ctttcttaag ttcgatagcg atacgaagac catcacggtc
     8461 agactcatca cgaacctcag caatcccagc taccttgtta ttaacacgaa catcatcgat
     8521 tttcttgact agattggcct tattgatttc ataaggaatc tcagtaataa cgatttgttc
     8581 cttaccacct tttagctttt caatttcagt cttggaacga acaaccacgc gccctttccc
     8641 agtctcataa gctttcttga tttcatcacg accctgaata atagcccctg tagggaagtc
     8701 tggtccaggc aagaattcca tgagtttatc aatctttgca gttgggtggt caatcatgta
     8761 aactgcagca tctatgacct cagctaaatt atggggagga atgtctgtgg cataaccagc
     8821 cgaaatccca gtcgaaccat tgaccaagag gtttggaaag gctgctggca agaccgttgg
     8881 ttctttctcc gtatcgtcaa agttccatgc aaaaggaact gtatttttct cgatatcctg
     8941 aagaaggtag cctgcaattt cagacaaacg tgcctcagta taacgcatag ccgcaggagg
     9001 atctccgtcc atagaaccgt tattaccgtg catttcaact agaatctcac gatttttcca
     9061 gttctgtgac atacgaacca tggcatcata gatagaagaa tccccgtgtg ggtggaaatt
     9121 ccccatgatg ttcccgactg acttggccga cttacggtag ctcttgtcaa aagtattgct
     9181 atccttattc atagaataaa gaatacggcg ctgaaccggc ttcaacccat cacgaatatc
     9241 tggcaaagcc cggtcttgaa taatgtactt ggagtagcga ccaaagcgct ctcccatgat
     9301 gtcctccagg gacatgtttt gaatgttaga cataagatac aaagcccata aaataccaag
     9361 tgaaaataga aaattcttga agtaagcaaa ctcacaagag aatttatctt tttcacacag
     9421 tatctagggc gtgttcaact cctttcaaag aatgtagagt aggtttttat gcagtaaaag
     9481 atattttacg ggaattcgtc ccgtgttcag ttacgataag taaccaaact atcctgtttg
     9541 tatttttcaa tatgaaaatc tggttttcca aaattagtct tagtttgtgt cttagccgct
     9601 cccttaaacg cctctttgag ataagcactc atagaagatt cttcattaat aatcctgcaa
     9661 ttttttcaaa ccaagatttt caaactgctt ttttacatag tcattcacat ccgactctaa
     9721 tttccagttt actaacatat tattttcttt cattaaaaca ctgtcgcttc ttctagcgta
     9781 aacttgacat tatcttcaat ccatttacgg cgtggttcta ccttatctcc catgagaaca
     9841 ttgacgcggc gttcggcgcg cgctaaatct tcaattgtga cacggatgag ggtacgtgtt
     9901 tctgggttca tggttgtttc ccagagctgg tccgcattca tctcaccaag tcctttgtat
     9961 cgttggaggg tagcgccttt accgaactgt ttacggagtt cttctagttc tccgtccgtc
    10021 caagcgtagg ccacttcttc tttcttgcct ttacctttgg acatcttgta aagaggtggg
    10081 agggcaatat agacatgacc tgcctcgact agcggacgca tgtaacggta gaaaaatgtc
    10141 aagagcaagg tctggatatg ggcaccgtcg gtatccgcat cggtcatgat aatgatctta
    10201 tcatagttgg catcttcaat agagaagtct gctccaacac ccgcaccaat ggtataaatc
    10261 atggtattga tctcttcatt tttgaggata tccgccatct tggccttggc tgtattgaca
    10321 accttaccac gaagaggtag aatagcctgg aacttgcggt cacgaccttg tttggcagaa
    10381 ccaccggcag agtccccctc aactagatag agttcattct tagcaggatt cttagattgg
    10441 gctggggtca atttcccaga caacaagccc ttatctttct tgtttttctt cccatttcgg
    10501 ctctcatcac gcgccttacg tgctgcttca cgagcatcac gggccttgat agccttgcgg
    10561 atgaggttag aagctaattc cccattttcc ataaggaaaa aggtcaactt atcagccact
    10621 attccatcca caactgggcg agctaggggg cttcctagtt tatccttggt ctgtccttca
    10681 aactgcaagt gttcttcagg aactaagata gaaagaacgg ccgctagtcc ctcacgatag
    10741 tctgaacctt caaggttttt atctttttcc ttgagaagac ctgttttacg tgcatagtca
    10801 ttcatgacct tggtaatggc agacttgagt cctgtctcgt gcgttccacc gtccttggtg
    10861 cgaacgttat tgacaaagga tagaatgtta tctgagaatc cgtcattgta ctggagggct
    10921 acttccactt gaaaaccatt gtcttcccct tcaaagtaaa gaactggcgt caagatttcc
    10981 ttatcttcgt tgagataaga aacaaaatct tgtactccat tctcatagtg gaactcaatc
    11041 gcttcatctg ttcgcttgtc cgttaaagac aaggtcacat ttttcaagag aaaggctgat
    11101 tcattaaggc gctctgaaat ggtattgtac ttgaaatctg tcgtagaaaa gatagtcgcg
    11161 tcaggcataa aagtaacttt ggtgcctgtt ttagacttgg gtgctgtacc gattttcttc
    11221 aaagtcgtga caggttttcc accattttcg aaacgttgct tgtaaactgc gccatcacgg
    11281 gtaatttcaa cttctaacca gctagaaagg gcgttaacaa cggaagaacc cactccgtga
    11341 agtccacctg atgtcttata gccaccttga ccgaatttcc ctccggcatg aagaatggta
    11401 aagataacct caacagttgg aattcccata gcgtgcatac ctgtcggcat cccacgtcca
    11461 tggtcttgaa ccgttagact accgtcttta ttgatagtta catcgatacg atcaccaaac
    11521 ccagacaagg cttcatcgac tgcattatca acgatttccc aaactaggtg atgaagacca
    11581 gcgccatcgg tcgatccaat atacatcccc ggacgttttc ggaccgcatc caacccttct
    11641 agcacctgaa tagcatcatc attataattg ttaatattga tttccttttt tgacacaagg
    11701 aacctcctat tcgttcatct ttactattct acaggttttc caaggatttt gcaaaatttt
    11761 tctttctccg atgtgacaat ttcagcagag attctctgct tttctttccc aattcatgat
    11821 ataataggag tatgattaca atagttttat taatcctagc ctatctgctg ggttcgattc
    11881 catctggtct ctggattgga caagtattct ttcaaatcaa tctacgcgag catggttctg
    11941 gtaacactgg aacgaccaat accttccgca ttttaggtaa gaaagctggt atggcaacct
    12001 ttgtgattga ctttttcaaa ggaaccctag caacgctgct tccgattatt tttcatctac
    12061 aaggcgtttc tcctctcatc tttggacttt tggctgttat cggccatacc ttccctatct
    12121 ttgcaggatt taaaggtggt aaggctgtcg caaccagtgc tggagtgatt ttcggatttg
    12181 cgcctatctt ctgtctctac cttgcgatta tcttctttgg agctctctat cttggcagta
    12241 tgatttcact gtctagtgtc acagcatcga tcgcggctgt tatcggggtt ctgctctttc
    12301 cactttttgg ttttatcctg agtaactatg actctctctt catcgctatt atcttagcac
    12361 ttgctagttt gattatcatt cgtcataagg acaatatagc tcgtatcaaa aataaaactg
    12421 aaaatttggt cccttgggga ttgaacctaa ctcatcaaga tcctaaaaaa taggctcttt
    12481 gtcaactgta gtgggttgaa aaaaagctaa gcttgagaaa ggacaaattt tgtcctttct
    12541 tttttgatat tcagagcgat aaaaatccgt tttttgaagt tttcaaagtt tcgaaaacca
    12601 aaggcattgc gtttgataag tttgatgaga ttattggtcg cttccaattt ggcgtttgaa
    12661 tag
//
LOCUS       DAVLHC010000049        12377 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.050, whole genome shotgun sequence.
ACCESSION   DAVLHC010000049 DAVLHC010000000
VERSION     DAVLHC010000049.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 12377)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12377)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12377
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.050"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            30..839
                     /locus_tag="VXE25_001713"
     CDS             30..839
                     /locus_tag="VXE25_001713"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000926538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HEV0772138.1"
                     /translation="MLLQKELIPMIEANLPNMAYAEKDIAKFFLKQQPLNDYSSKALC
                     EYLNVSKATLTRFAKKCGFKGFRQFIFKYQEMIHEKEKLALYTEATEKVLSDYEEMLR
                     KTYTVLDEVQLERIAEMIETAERVYLYGKGSSVLALQEMKMRFMRLGVIGEVLSDEDM
                     ILWSSLLLNENCLVIGASISGQTDIVLEGLQKAADKGAKTVLMTTRKFDEEDCFFDEL
                     LLLASTDHLSYGNRISPQFPILLITDCLFSNYLESPERQYYYNQTIIHKEE"
     gene            844..1545
                     /locus_tag="VXE25_001714"
     CDS             844..1545
                     /locus_tag="VXE25_001714"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000078476.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmannosamine-6-phosphate 2-epimerase"
                     /protein_id="HEV0772139.1"
                     /translation="MSQIWTKEKFISQVQGGVIVSCQALPGEALYNEEFSLMPFMAKA
                     ALEAGAVGIRANSVRDIKAIQKVVDLPIIGIIKRDYPPQEPYITATMKEVDELVECGT
                     TVIAFDATLRPRYDGLVVSEFIKKIKEKYPNQLLMADVSNLDEGLYAFKSGVDFVGTT
                     LSGYTSTSVQSDEPDFELMKKLADFNIPVIAEGKIHYPEQLKKAYSLGVTSVVIGGAI
                     TRPKEIAQRFINVIK"
     gene            1570..2487
                     /locus_tag="VXE25_001715"
     CDS             1570..2487
                     /locus_tag="VXE25_001715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002894436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylneuraminate lyase"
                     /protein_id="HEV0772140.1"
                     /translation="MKDLTKYKGVIPAFYACYDENGEISQDRVKSLVQYFIDKGVKGI
                     YVNGSSGECIYQSVEDRKQIIEAVMEVAKGKLTVINHIACNNTKDSIELAKHSESVGV
                     DAIAAIPPIYFKLPEYSIAAYWNAMSEAASNTDFIIYNIPQLAGVALTGSLYATMRQN
                     PRVIGVKNSSMPVQDIQMFVAAGGEDYIVFNGPDEQYLGGRLMGAEAGIGGTYGVMPD
                     LFLKLESLIQERDLDTAKKLQYAINEVIYKMISGKANMYAVAKEVLRLNEKLDLGSVR
                     QPLEALAEGDLEVAKQAAELIQQARKEFL"
     gene            2515..4056
                     /locus_tag="VXE25_001716"
     CDS             2515..4056
                     /locus_tag="VXE25_001716"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000537364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:solute symporter"
                     /protein_id="HEV0772141.1"
                     /translation="MGTTGFTIIDLIILIVYLLAVLVAGIYFSKKEMKGKEFFKGDGS
                     VPWYVTSVSIFATMLSPISFLGLAGSSYAGSWILWFAQLGMVVAIPLTIRFILPIFAR
                     IDIDTAYDYLDKRFNSKALRIISALLFIIYQLGRMSIIMYLPSAGLSVLTGIDINILI
                     ILMGVVAIVYSYTGGLKSVLWTDFIQGVILISGVVLALFVLIANIKGGFGAVAETLAN
                     GKFLAANEKLFDPNLLSNSIFLIVMGSGFTILSSYASSQDLVQRFTTTQNIKKLNKML
                     FTNGVLSLATATVFYLIGTGLYVFYQVQNADSAASNIPQDQIFMYFIAYQLPVGITGL
                     ILAAIYAASQSTISTGLNSVATSWTLDIQDVISKNMSDNRRTKIAQFVSLAVGLFSIG
                     VSIVMAHSDIKSAYEWFNSFMGLVLGLLGGVFILGFVSKKANKQGAYAALIVSTIVMV
                     FIKYFLPPTAVSYWAYSLISISVSVVSGYIVSVLTGNKVSAPKYTTIHDITEIKADSS
                     WEVRH"
     gene            4075..4533
                     /locus_tag="VXE25_001717"
     CDS             4075..4533
                     /locus_tag="VXE25_001717"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000587138.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhcH/YjgK/YiaL family protein"
                     /protein_id="HEV0772142.1"
                     /translation="MIISEQSDFKRYASVNKYFSKVCDFLENTNLTDLVDGKIDIDGE
                     NVFANCMTYLADGVPGDIFETHKKYLDIHIVVENTEKMAVTSPVRAQSRVPFSEEKDI
                     AFYDSKDYQIVELLPGNMLVTFEEDLHQPKIHCNDETVKKLVIKVLNEEK"
     gene            4535..6757
                     /locus_tag="VXE25_001718"
     CDS             4535..6757
                     /locus_tag="VXE25_001718"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000739354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exo-alpha-sialidase"
                     /protein_id="HEV0772143.1"
                     /translation="MKKNIKQYVTLGTVVVLSAFVANSVAAQETETSEVSTPKLVQPV
                     APTTPISEVQPTSDNSSEVTVQPRTVETTVKDPSSTAEETPVLEKNNVTLTGGGENVT
                     KELKDKFTSGDFTVVIKYNQSSEKGLQALFGISNSKPGQQNSYVDVFLRDNGELGMEA
                     RDTSSNKNNLVSRPASVWGKYKQEAVTNTVAVVADSVKKTYSLYANGTKVVEKKVDNF
                     LNIKDIKGIDYYMLGGVKRAGKTAFGFNGTLENIKFFNSALDEETVKKMTTNAVTGHL
                     IYTANDTTGSNYFRIPVLYTFSNGRVFSSIDARYGGTHDFLNKINIATSYSDDNGKTW
                     TKPKLTLAFDDFAPVPLEWPREVGGRDLQISGGATYIDSVIVEKKNKQVLMFADVMPA
                     GVSFREATRKDSGYKQIDGNYYLKLRKQGDTDYNYTIRENGTVYDDRTNRPTEFSVDK
                     NFGIKQNGNYLTVEQYSVSFENNKKTEYRNGTKVHMNIFYKDALFKVVPTNYIAYISS
                     NDHGESWSAPTLLPPIMGLNRNAPYLGPGRGIIESSTGRILIPSYTGKESAFIYSDDN
                     GASWKVKVVPLPSSWSAEAQFVELSPGVIQAYMRTNNGKIAYLTSKDAGTTWSAPEYL
                     KFVSNPSYGTQLSIINYSQLIDGKKAVILSTPNSTNGRKHGQIWIGLINDDNTIDWRY
                     HHDVDYSNYGYSYSTLTELPNHEIGLMFEKFDSWSRNELHMKNVVPYITFKIEDLKKN
                     "
     gene            6797..7906
                     /locus_tag="VXE25_001719"
     CDS             6797..7906
                     /locus_tag="VXE25_001719"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000248711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="HEV0772144.1"
                     /translation="MVNYGIVGAGYFGADLARSMNKIEDAKVVAVFDPNHGEEVAQEL
                     GSDVCASLDELVAREDIDCVIVASPSYLHREPVVKAAQHGKHVFCEKPIALSYEDCKA
                     MVDACKENNVIFMAGHIMNFFNGVHHAKELITQGKIGKVLYCHAARTGWEEQQPTVSW
                     KKLRSQSGGHLYHHIHELDCIQFIMGGLPEKATMVGGNVYHKGENFGDEDDMLIVNLE
                     YSDDRYAVLEYGNAFRWGEHYVLIQGTEGAIKLDLFNTGGTLRVKGEGESHFLVHETQ
                     EEDDDRTAIYTGRGMDGAIAYGKPGVRCPLWLQTCIDKEMEYLHDIIKGGEITEEFEK
                     LLNGVAALESIATADACTLSVKEDRKVSLSEITNA"
     gene            8063..8953
                     /locus_tag="VXE25_001720"
     CDS             8063..8953
                     /locus_tag="VXE25_001720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HEV0772145.1"
                     /translation="MKIIGIDIGGTTIKADLYDEFGTSLNHFKEIETIIDYDLGTNQI
                     LNQVCDLIGEYTLNHSIDGVGISTAGVVNANTGEIIYAGYTIPGYIGVNFTAEIEKRF
                     GLYTFVENDVNCAALGELWKGQAKDKKNVVMVTIGTGIGGSIIVNGQIVNGFNYTAGE
                     VGYIPVGNSDWQSKASTTALIHLYQKKSLKTNQTGRTFFTDLRSGDKVAEETFEIFVE
                     NLTKGLLTISYLLNPEILILGGGILDSKDILLPEIQSSLAKNAMDNRFLPKNLVAATL
                     GNEAGRIGAVKNFLDRISNK"
     gene            8978..9301
                     /locus_tag="VXE25_001721"
     CDS             8978..9301
                     /locus_tag="VXE25_001721"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000185366.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772146.1"
                     /translation="MTNSVFSTMQDIENVATDIIKSYDNEIYTYKAVSQEELEKLEKS
                     YDEKSHEELVSIESNLEMKQQNLIDEVNKTIKENDANIQYISSSRRGEFVEKIIGRVV
                     EKYGH"
     gene            9291..11282
                     /locus_tag="VXE25_001722"
     CDS             9291..11282
                     /locus_tag="VXE25_001722"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001018351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit I"
                     /protein_id="HEV0772147.1"
                     /translation="MAISQMKRISLLFSKSSLDDVLKTIQELESVQFRDLKVQDNWSE
                     ALEKDEVVFPTIQIFHTSNSNHGVIEGNDALTYLMNQQQHLEATVEKLQEYLPKENTF
                     KLLQQPPITTSYEELEKFGKANVAEGVLKKVNHQINRVHELERHIQSNNEEIERLIKW
                     EKLEIVPANLEQFSFCKGKVGTIPRTEDNRLYNSLLENNIEVQEIFSNDREYGVVVFY
                     QSSYSIDFDEYLFEPFDYSRKELPKQRVVDLDQENMQLITEKENIIASLQDSKKYLID
                     LQWQIDYILSIYARQISKNNFLCTPHLVALEGWIEETRILYFIKVMDEHFGHSIYIYE
                     SETLTDNQDEIPIKLTNHSLIEPFELLTEMYALPKYYEKDPTPVLAPFYFTFFGMMVA
                     DLGYGLLLFLGTMLALKIFHLPSATKRFLKFFNILGVAVAIWGGIYGSFFGYELPFHL
                     ISTTSDVMTILVVSVVFGFITVFAGLLASGLQKVRMKKYAEAYNSGFAWCVILLGLLF
                     IAVGMLMPDMRPLFVLGKWVSIFNAVGILIVSIIQTKSLSGIGAGLFNLYNISSYIGD
                     LVSFTRLMALGLSGASIASAFNLIVGLFPGILAKLTIGLVLFILLHAINIFLSLLSGY
                     VHGARLIFVEFFGKFYEGGGKPFQPLKASEKYIKVITKN"
     gene            11298..11774
                     /locus_tag="VXE25_001723"
     CDS             11298..11774
                     /locus_tag="VXE25_001723"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400486.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit K"
                     /protein_id="HEV0772148.1"
                     /translation="MEHLATYFSTYGGAFFAALGIVLAVGLSGMGSAYGVGKAGQSAA
                     ALLKEQPEKFASALILQLLPGTQGLYGFVIGILIWLQLTPELPLEKGVAYFFVALPIA
                     IVGYFSAKHQGNVAVAGMQILAKRPKEFMKGAILAAMVETYAILAFVVSFILTLRV"
     gene            11808..>12377
                     /locus_tag="VXE25_001724"
     CDS             11808..>12377
                     /locus_tag="VXE25_001724"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000067169.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772149.1"
                     /translation="MSNLENLRESVIEQAHEKGRMKLLDSKKKIDDEFEMQKSLIIKK
                     KEAEHERKLKELQQKYQIIFQQLKNKERQSTLVSKQKILKELFQSALLEMESWSADKE
                     MEFIYRILERYSQQEVIVTFGERTLAKFNLEQLEKLKFSFPNYLFSEQPISNESGLLI
                     SIGKIDDNYLYKTLIGSISKEESSSIANQI"
BASE COUNT         4197 a         1780 c         2444 g         3956 t
ORIGIN      
        1 taaacgttta cttcaactaa ggagctcata tgttactgca aaaagaacta attccaatga
       61 tagaagctaa cttaccaaat atggcatatg ctgaaaaaga cattgctaaa ttcttcttaa
      121 aacagcaacc tctgaatgat tattcatcta aagcattgtg cgaatacctt aatgtatcca
      181 aagcaacatt gactcgattt gcgaaaaaat gtggttttaa aggttttaga caattcattt
      241 tcaaatacca agagatgatt catgagaaag aaaagttggc attatataca gaggcaacag
      301 aaaaagtttt atccgactat gaggaaatgt tgagaaaaac ttacacggtt cttgatgaag
      361 ttcaacttga gcgtattgct gagatgatag aaactgctga gcgtgtatat ctctacggta
      421 aaggaagttc tgttcttgct ttacaagaaa tgaagatgag atttatgcgt ctcggagtga
      481 ttggtgaagt attatcagac gaggatatga ttttgtggag tagcttacta cttaatgaaa
      541 attgccttgt cattggagca tccatttcag gtcaaactga tattgtacta gaaggtctac
      601 aaaaagctgc agataaaggc gctaaaacag ttttaatgac tacaagaaaa tttgacgaag
      661 aagattgttt ctttgatgaa ctattgttat tagcttcgac cgatcatctc tcgtatggca
      721 atcgcatatc acctcagttt ccaatacttt taattacaga ctgcttattc tctaattatc
      781 tggaaagtcc agagagacaa tattattaca atcaaactat tatccataag gaggaataat
      841 aaaatgagcc aaatttggac taaagaaaaa tttataagcc aagttcaagg tggagtcatt
      901 gtttcttgtc aagctttacc tggtgaagcc ctttataatg aagaatttag cttgatgcct
      961 tttatggcta aagcagcttt agaggcagga gcagtgggca ttcgcgcaaa ttctgtgcgt
     1021 gatattaaag caattcagaa agtagtagat ttaccaataa ttggaattat caaaagggat
     1081 tatccacctc aagaaccata tattactgct acgatgaaag aagtagatga acttgtagaa
     1141 tgcggaacaa cagtcattgc atttgatgca actttaagac caagatatga tggcttagtt
     1201 gtcagtgaat ttatcaaaaa aataaaagaa aaatatccga atcaattgct gatggcggat
     1261 gtaagtaatt tagatgaagg tctctatgca tttaaatcag gcgttgattt tgttggtaca
     1321 acattatcag gttacacaag tacaagtgta caatcagatg agcctgattt tgaactaatg
     1381 aaaaaattgg ctgattttaa tattccggta attgccgaag gaaaaattca ttatccagaa
     1441 caattaaaaa aagcttatag tttaggtgtt accagtgtag tcattggtgg agcgattaca
     1501 cgtccaaaag aaattgctca gcgatttatt aatgtcatca aataaaaaac aatataaagg
     1561 agaaatctga tgaaagattt aactaaatac aaaggcgtta tccctgcatt ttatgcttgc
     1621 tatgatgaaa atggtgaaat tagccaagat cgtgtaaaat ctctggtaca atatttcatt
     1681 gacaaaggtg taaaaggtat ctatgtaaat ggttcttcag gtgaatgtat ttaccaaagt
     1741 gtagaagatc gtaaacaaat tattgaagct gttatggaag ttgctaaagg taaattaaca
     1801 gttatcaacc atattgcatg taataacacg aaagatagta tcgaattggc aaaacattca
     1861 gaaagtgttg gagtcgatgc tattgcagct atcccaccta tttatttcaa attgccagag
     1921 tattcaatcg cagcatattg gaatgcaatg agtgaagctg cgtcaaatac agattttatt
     1981 atctataata ttccacaatt ggcaggggtt gcgttgactg gtagtttgta tgcaacaatg
     2041 cgtcaaaatc ctcgtgtgat tggagttaaa aattcttcta tgcctgtaca agatattcaa
     2101 atgtttgtag ctgcaggtgg agaagattac attgtattca atggtccaga tgaacaatat
     2161 cttggtggtc gcttgatggg agcagaagct ggtattggtg gtacttatgg cgttatgcca
     2221 gatttgttct tgaaattgga aagtttgatt caagaacgag atttagatac agctaaaaaa
     2281 cttcaatatg ctatcaatga agttatctat aagatgatat caggtaaggc aaatatgtat
     2341 gctgtagcaa aagaagtttt gcgtctaaat gaaaaacttg atttaggttc tgttcgtcaa
     2401 cctttagaag cattggcaga aggtgacttg gaagttgcaa aacaagcagc agaacttatt
     2461 caacaagcac gaaaagaatt tttataataa ataaaatcaa tatggagata tgttatgggc
     2521 acaacaggat ttacaataat tgacttaatt atcttgattg tttatttact tgcggtgttg
     2581 gttgcaggta tctatttctc taaaaaagag atgaaaggaa aagagttctt taaaggagat
     2641 ggttcggttc cttggtatgt tacttcggta tccatttttg ccacaatgct cagtccgatt
     2701 tccttcttgg gactcgctgg tagctcttat gcaggtagct ggattttatg gtttgctcaa
     2761 ttagggatgg tagtagctat tccactgaca attcgtttta tcttacctat ctttgcacgg
     2821 atagacatcg atacggcata tgattacttg gataaacgtt ttaattctaa agcacttcgt
     2881 attatttcag cactcttgtt tattatttat caattgggac gtatgtctat cattatgtac
     2941 ctcccatcag ctggtttatc agtattgaca ggaattgaca tcaatatttt gattattttg
     3001 atgggtgtag ttgcaattgt ttattcttat actggtggtc taaaatccgt attatggaca
     3061 gactttattc aaggtgtgat tctgattagt ggtgtcgttt tagctttatt tgtactgatt
     3121 gctaatatta aaggtggctt tggtgcagta gcagaaacat tagcaaacgg gaaattcctt
     3181 gctgcaaatg aaaaactttt cgatcctaac ttgctttcaa actccatctt tttaattgtg
     3241 atgggttcag gctttacaat cttgtcttcc tatgcttcat ctcaagattt ggttcaacgt
     3301 tttactacaa cacaaaatat taagaaactt aataagatgt tgttcacaaa cggtgttttg
     3361 tcacttgcaa ctgcaacagt cttttacttg attggtacag gcttgtacgt attctatcaa
     3421 gtacaaaatg cagatagtgc agctagcaat atccctcaag accaaatctt tatgtacttt
     3481 attgcatacc agttaccagt aggtatcaca ggtttgatct tggcagcgat ttatgcagca
     3541 tctcaatcaa ctatttcaac aggtttgaac tctgttgcaa cttcatggac attggatatt
     3601 caagatgtca tttctaaaaa tatgtcagac aatcgtcgta cgaaaattgc acaattcgta
     3661 tctctagcag taggtttatt ctcaattggt gtttccattg tcatggctca ctcagatatt
     3721 aaatctgcat acgaatggtt caatagtttc atgggacttg tacttggtct acttggtggt
     3781 gtatttattc ttggatttgt ttctaaaaaa gcaaataaac aaggtgctta tgcagcgctg
     3841 attgtatcaa ccatcgtcat ggtatttatt aaatacttcc ttcctccaac agctgttagc
     3901 tactgggcat attcattgat ttcaatctct gtatcagtag tttcaggtta tattgtatct
     3961 gttcttactg gaaataaagt atctgcacct aaatatacaa cgattcatga tattacagaa
     4021 attaaagcgg attcaagttg ggaagttcgt cactaataga aaagagaaaa taatatgatt
     4081 atttctgaac aatctgattt taaacgatat gcttctgtca ataaatattt ttcaaaagtc
     4141 tgtgattttt tagaaaatac aaatttgaca gatttagttg atggaaaaat tgatattgac
     4201 ggggaaaatg tttttgcaaa ttgtatgact tatctagctg atggagttcc aggagatatt
     4261 tttgaaactc ataagaaata tttagatatt catattgttg ttgaaaatac tgaaaaaatg
     4321 gcagtaactt ccccagttcg tgcccagtca cgtgtacctt ttagcgaaga gaaggatatt
     4381 gctttttacg atagcaaaga ctatcaaatt gttgaattgc ttccagggaa tatgttggtg
     4441 acttttgaag aagatcttca ccaaccaaag attcattgca atgatgaaac tgttaaaaaa
     4501 cttgttatca aagttttaaa cgaggaaaaa taaaatgaaa aaaaatatta aacaatatgt
     4561 aaccttaggt actgtagtgg tattatcagc atttgttgct aactcagttg cagctcagga
     4621 gactgaaact tctgaagtat caacaccaaa gttggtgcaa cctgttgcac caacgactcc
     4681 gatttcggaa gtacaaccta catcggataa ctcttcggaa gttactgtac aacctcgaac
     4741 agttgaaact actgttaagg atccatcttc tacagcggaa gaaactcctg tcttagaaaa
     4801 aaataatgtt actttaacag ggggcggaga aaatgttact aaagagttaa aggataaatt
     4861 tactagcggt gactttactg tagtgattaa gtacaatcag tcaagtgaga aaggcttaca
     4921 agctctgttt ggaatatcta attccaaacc cggtcaacaa aatagttatg tagatgtgtt
     4981 ccttagagac aatggtgagt tggggatgga agcgcgtgat acttcttcca ataaaaataa
     5041 cctagtatcc agacctgctt cagtttgggg taagtacaaa caagaggctg tgactaacac
     5101 tgttgcagta gtagcagatt cagtcaaaaa aacatattct ttatacgcaa atggtacaaa
     5161 agtagtagaa aagaaagtgg ataatttcct aaacatcaag gatattaaag gtattgatta
     5221 ctatatgctt gggggagtga aacgtgcagg aaaaacggcg tttggtttta acggaacact
     5281 agaaaatatc aaattcttta atagtgcatt ggatgaagaa actgttaaaa agatgacaac
     5341 aaacgctgtt actggacatt taatttatac ggctaatgat acaacaggtt ctaactattt
     5401 ccgtattcca gttctgtata cttttagcaa tggtcgggta ttttcaagca ttgacgctcg
     5461 ttacggtgga actcatgatt tcttgaataa aattaatatt gctacaagtt atagtgatga
     5521 taatggtaag acatggacta aaccaaaatt aacattggca ttcgatgatt ttgcgccagt
     5581 accattagaa tggcctcgtg aagttggtgg acgtgactta caaatcagcg gtggtgcaac
     5641 ctatattgac tctgttattg ttgaaaaaaa gaacaaacaa gtactcatgt ttgctgatgt
     5701 gatgcctgct ggagtaagtt ttagagaagc aactagaaaa gattcaggtt ataaacaaat
     5761 tgatggtaat tattacctta aattaaggaa acaaggtgat actgattaca attatactat
     5821 tcgtgagaat ggtactgtat acgacgatcg taccaacaga ccaactgaat tttcagtaga
     5881 taaaaatttc ggtattaaac aaaatggtaa ttatttgacg gtagagcaat attcggtttc
     5941 atttgaaaat aataaaaaga ctgaatatcg taatgggact aaagtccata tgaatatctt
     6001 ctacaaagat gcattgttta aagtagtgcc aacgaactat attgcatata tttctagcaa
     6061 tgatcatggc gaatcttggt ctgcaccaac tttattacct cctataatgg gacttaatcg
     6121 gaatgcgcca tatttaggtc ctggacgtgg aatcattgaa agctcaactg gacgtattct
     6181 tattccgtct tacactggta aagagtctgc gttcatttat agtgacgata atggagcatc
     6241 ttggaaagtt aaagtagtgc cacttccttc tagttggtca gcagaagcac aatttgtaga
     6301 attgagtcca ggagtaattc aagcatatat gcgtacaaat aatggtaaaa ttgcatattt
     6361 aacaagtaaa gacgcaggta ctacttggag tgcaccggaa tatttgaaat ttgtttcaaa
     6421 tccaagttat ggaacacaat tatcaatcat caattatagc caattgattg atggtaaaaa
     6481 ggctgtcatt ttaagtactc caaactccac aaatggtcgt aaacacggac aaatttggat
     6541 tggtctaatt aatgatgata atacaattga ttggcgttat catcacgacg ttgattatag
     6601 taactatgga tactcatatt caacattgac agagttacca aatcatgaaa ttggattgat
     6661 gtttgaaaaa tttgattcat ggtctcgtaa tgaacttcat atgaaaaatg ttgtaccata
     6721 tataacattt aagattgaag atctgaaaaa gaattaaagc tgaaatttga aaatatataa
     6781 aaagaggata aaaattatgg taaattacgg tattgttgga gctggatatt ttggagctga
     6841 tttagctcgc tcaatgaaca aaattgaaga tgcaaaagtg gttgcggtat ttgacccaaa
     6901 tcatggagaa gaagttgctc aagagttggg atcagatgtt tgtgcaagtt tagatgaact
     6961 tgtagcacgt gaagatattg attgtgtgat cgtagcttca cctagctacc ttcaccgtga
     7021 accagttgtg aaagctgctc aacatggcaa acacgtattt tgtgaaaagc caattgcatt
     7081 gtcttatgaa gattgtaaag ccatggttga cgcatgtaaa gaaaataatg tcatctttat
     7141 ggctggtcac atcatgaact tctttaacgg tgtacaccat gctaaagaat tgattactca
     7201 aggtaaaatc ggtaaagttc tttattgcca tgctgctcgt acaggttggg aagaacaaca
     7261 accaactgta tcatggaaga aacttcgttc tcaatctgga ggacatttgt accaccatat
     7321 tcatgaatta gattgcattc agtttatcat gggaggactt cctgaaaaag cgacaatggt
     7381 aggaggcaat gtatatcata aaggtgaaaa ctttggtgat gaagatgata tgctcattgt
     7441 aaacttagaa tactctgatg atcgttatgc tgttttggaa tatggtaatg ctttccgttg
     7501 gggtgaacac tacgtcttga ttcaaggaac tgaaggagct atcaaacttg acttgttcaa
     7561 tactggcggt actcttcgtg ttaaaggtga aggagaatca cacttcttag ttcatgaaac
     7621 tcaagaggaa gatgatgatc gtacagctat ctataccggt cgtggtatgg atggagcaat
     7681 tgcgtacggt aaaccaggag tacgttgccc attatggttg caaacatgta ttgataaaga
     7741 aatggaatat ctacatgaca tcattaaagg tggagaaatt acagaagaat ttgaaaaact
     7801 tctcaatggt gtagctgctt tagaatcaat cgctaccgct gatgcatgta ctttatcagt
     7861 taaagaagat cgaaaagtaa gtctttcaga aatcacaaat gcttaacttt tgtaaaacag
     7921 aatagtaaat tcttgtcatt atataatttc taaagttctg tgatacaact cattgaataa
     7981 agaaatagag atgggactgg gataatgccc agtcccattt tttatcaaaa agtaatgaga
     8041 tcaaaaatgt gggagtgttg aaatgaagat tataggtatc gatattggcg gaacaacaat
     8101 taaggcagat ttatacgatg agtttggaac gagtttgaat catttcaaag agatagaaac
     8161 aattattgac tatgatttgg gaacgaatca gatattaaat caggtctgtg atttaattgg
     8221 tgagtatact ttaaatcatt caattgatgg tgttgggatt tccactgctg gagttgttaa
     8281 tgctaatact ggagaaatca tctatgcagg ctatacaata ccagggtata tcggagtaaa
     8341 ctttactgcc gaaatagaaa aacgttttgg gttgtatact tttgttgaaa atgatgttaa
     8401 ttgtgctgca ttaggtgaat tgtggaaggg acaagccaaa gataagaaaa atgtagtaat
     8461 ggttactatt ggaacaggta taggaggcag tattattgtc aacggacaaa ttgttaacgg
     8521 atttaactat actgctggtg aagtaggtta tattcctgta ggtaattcgg attggcaaag
     8581 taaagcctca acaaccgcat tgattcattt atatcaaaaa aagagcttga aaactaatca
     8641 aactggacgt actttcttca ctgatttaag atctggagat aaagttgctg aagaaacttt
     8701 tgaaattttt gtagaaaatc taacaaaagg tttattaacg atttcttatc tacttaatcc
     8761 agaaattctc atattaggag gtgggattct ggatagtaag gatattttgt tacctgaaat
     8821 tcaaagttct ttagctaaaa atgcaatgga taataggttt ttacctaaaa atcttgtggc
     8881 agctacatta ggaaatgaag ctggtcgtat aggagctgta aaaaatttct tagatagaat
     8941 ttctaataaa tagtatgtaa gataaggagg tgtcacaatg actaactctg tattttcgac
     9001 aatgcaagat attgagaatg ttgcaaccga tattataaaa tcatatgata atgagattta
     9061 tacttataaa gctgtttccc aagaagaatt ggaaaaacta gaaaaaagtt atgatgaaaa
     9121 aagtcacgaa gaattagttt caatagaaag caatttagaa atgaaacaac agaaccttat
     9181 tgatgaggtt aataaaacaa tcaaggaaaa tgatgcaaat attcagtata tttcatcaag
     9241 taggagagga gaatttgtag aaaaaattat tggtagggtg gtagaaaaat atggccatta
     9301 gtcagatgaa aagaatctct ctactatttt ctaaaagtag tcttgatgat gttttaaaaa
     9361 ctattcaaga actagagtca gtgcagttcc gtgatttaaa ggttcaggat aactggtcag
     9421 aagctctaga aaaagatgaa gttgtatttc caactattca aatttttcat acttctaatt
     9481 ccaatcatgg ggttattgag ggaaatgatg ccttgactta tttgatgaat caacaacaac
     9541 atttagaagc aactgtagag aaattacaag aatacctacc gaaagaaaac acgtttaaat
     9601 tattgcagca acctccgata actacctctt atgaagaatt agagaaattt ggtaaagcta
     9661 atgttgctga gggtgttctt aaaaaagtga atcatcaaat taacagagtt catgaattag
     9721 aaagacacat tcaaagtaat aatgaggaaa tagagcgatt aataaagtgg gaaaaattag
     9781 aaattgttcc tgcgaattta gaacaatttt ctttctgtaa aggaaaagtc ggaacaattc
     9841 caaggactga agataatcgc ttatacaata gtcttttaga aaacaatatt gaagttcaag
     9901 aaatattttc taatgataga gagtacggtg ttgttgtttt ctatcagtct agttactcta
     9961 tagattttga tgaatactta tttgaaccat ttgattattc tagaaaggaa ttaccgaagc
    10021 agcgagtagt agatttagat caagaaaaca tgcagttaat aactgaaaaa gagaatatta
    10081 tcgcatcgtt gcaagattca aagaaatatt tgatagattt acaatggcaa atagactata
    10141 ttttatctat ctatgctcgt caaatctcta agaataactt tttgtgcact ccgcatctag
    10201 ttgcattaga aggatggata gaagaaactc gtattttata ttttataaaa gttatggatg
    10261 agcattttgg acattctatt tatatttatg aatcggaaac attgacggat aatcaagatg
    10321 aaatacctat caaattaacg aatcattctt taattgaacc atttgaatta ttgacagaaa
    10381 tgtatgctct gcccaaatat tatgagaaag atcctacacc tgtattagca ccattttact
    10441 ttacattttt tggaatgatg gttgctgatt taggctatgg tttactattg tttttaggaa
    10501 caatgttagc attaaaaatt tttcatctac cttcagcaac taagagattt ttaaaattct
    10561 ttaatatatt aggggtagcc gttgcaattt ggggtggaat ctatggctca ttttttggat
    10621 atgagttgcc atttcatctg atatctacaa cctctgatgt catgactata ttagtagtgt
    10681 cagttgtgtt tgggtttatt acagtatttg caggtttgtt agcttcagga ctacaaaaag
    10741 taagaatgaa gaaatatgca gaagcatata attcaggatt tgcgtggtgt gttattctgc
    10801 ttggcttgtt atttattgct gttggaatgt tgatgcctga tatgagaccg ttatttgtat
    10861 tagggaaatg ggtatctatt tttaatgctg tggggatttt gattgtttct attattcaaa
    10921 ccaaaagctt gtcaggtatt ggagcaggat tgtttaatct atataacatt tcatcttata
    10981 taggtgattt agttagtttc actcgattga tggcattagg attatctgga gcaagtatag
    11041 catcagcttt caatttaatt gttggtttgt ttccgggaat attggctaaa ctgacaattg
    11101 gattagtatt attcattctt ttacatgcga tcaatatttt tctatcgtta ctatcaggat
    11161 atgttcatgg agcacgtctg atatttgttg aattttttgg taagttttat gagggtggag
    11221 gaaaaccatt tcaacctttg aaggcttctg agaaatatat taaggttatt acaaagaatt
    11281 aatggaggat atatataatg gaacatttag caacttattt ttcaacctat ggaggagctt
    11341 tcttcgctgc attgggaatt gtattggcgg ttggattaag cggtatgggg tctgcttatg
    11401 gagttggtaa ggctgggcaa tctgccgcag ctttactgaa agaacagcct gaaaagtttg
    11461 cctcagcttt gatattgcaa ttattgcccg gaacacaagg attatatggt tttgttattg
    11521 gaattttaat ttggttgcaa ttaactccag aacttccttt agaaaaaggc gttgcttatt
    11581 tctttgtagc tcttccaatt gctattgtag gatacttttc agctaagcat caaggaaatg
    11641 tagcagtagc gggaatgcaa atcttggcta aaagaccaaa agaattcatg aagggagcaa
    11701 ttttagctgc catggtagaa acctatgcaa ttcttgcttt tgtcgtatca ttcattttga
    11761 cccttcgtgt ataagaaata aatttgcaat tcaaaggagg tgtctaaatg agcaatttag
    11821 aaaacttacg agagtctgtt attgaacaag ctcatgaaaa agggcgtatg aaattattgg
    11881 attccaaaaa gaagattgat gatgaatttg aaatgcaaaa gtcgctcatt ataaagaaaa
    11941 aagaagctga acatgaacga aagttaaaag aattgcaaca gaaatatcaa ataatttttc
    12001 aacaattaaa aaataaggaa cgccaatcaa cgttagtatc aaaacagaaa atattaaaag
    12061 aactttttca atctgcttta ctagaaatgg aatcttggag tgcagataaa gaaatggagt
    12121 tcatctatcg aattctggaa cgatattcac aacaagaggt catagtaacc tttggggaac
    12181 ggactttagc taaattcaat ttggaacaat tagagaaatt gaaattctct tttccaaatt
    12241 atttatttag tgaacaacct atctcaaatg aatcaggctt acttatttca ataggtaaaa
    12301 ttgatgataa ctatttgtat aaaacattaa ttggatcgat ttctaaggaa gaaagttcaa
    12361 gtatcgcaaa tcaaatt
//
LOCUS       DAVLHC010000050        12060 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.051, whole genome shotgun sequence.
ACCESSION   DAVLHC010000050 DAVLHC010000000
VERSION     DAVLHC010000050.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 12060)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12060)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12060
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.051"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            72..1061
                     /gene="manX"
                     /locus_tag="VXE25_001725"
     CDS             72..1061
                     /gene="manX"
                     /locus_tag="VXE25_001725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000021981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose transporter subunit IIAB"
                     /protein_id="HEV0772150.1"
                     /translation="MSIGIIIASHGEFAAGIHQSGSMIFGEQEKVQVVTFMPNEGPDD
                     LYAKFNNAVAAFDAEDEVLVLADLWSGSPFNQASRVMGENPERKFAIITGLNLPMLIQ
                     AYTERLMDAAAGVEKVAANIIKEAKDGIKALPEELNPVEEVASAAAAPVAQAAIPEGT
                     VIGDGKLKINLARLDTRLLHGQVATAWTPDSKANRIIVASDNVAKDDLRKELIKQAAP
                     GNVKANVVPIQKLIEISKDPRFGETHALILFETPQDALRAIEGGVPIKTLNVGSMAHS
                     TGKTLVNTVLSMDKEDVATFEKMRDLGVEFDVRKVPNDSKKDLFDLINKANVK"
     gene            1089..1892
                     /locus_tag="VXE25_001726"
     CDS             1089..1892
                     /locus_tag="VXE25_001726"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000022712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose/fructose/sorbose transporter subunit
                     IIC"
                     /protein_id="HEV0772151.1"
                     /translation="MSIISMVLVVVVAFFAGLEGILDQFQFHQPLVACTLIGLVTGHL
                     EAGIILGGSLQMIALGWSNIGAAIAPDAALASVAAAIIMVLGGDFTKTGIGVAQAVAI
                     PLAVAGLFLTMIVRTISVGLVHTADAAAKKGDFGAVERAHFIALLFQGLRIALPAALL
                     LMVPTETVQSILSAMPDWLKDGMAIGGGMVVAVGYAMVINMMATREVWPFFALGFVLA
                     AVSDITLIGFGAIGVAIALIYLHLSKTGGNGGGGAATSNDPIGDILEDY"
     gene            1916..2827
                     /locus_tag="VXE25_001727"
     CDS             1916..2827
                     /locus_tag="VXE25_001727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose/fructose/sorbose transporter family
                     subunit IID"
                     /protein_id="HEV0772152.1"
                     /translation="MTEKLQLTKSDRKKVWWRSTFLQGSWNFERMQNLGWAYTLIPAI
                     KKLYTKKEDQIAALERHLEFFNTHPYVAAPVMGVTLALEEERANGVEIDDAAIQGVKI
                     GMMGPLAGIGDPVFWFTVRPILGSLGASLALTGNILGPLLFFVAWNLIRMSFLWYVQE
                     IGYKAGSEITKDMSGGILQDITKGASILGMFILAVLVQRWVNIKFAFDVSKVQLDEKA
                     YIHWDKLPEGSKGIQEAFAQVGQGLSQTPEKVTTFQQNLDMLIPGLSGLLLTLLCMYL
                     LKKKVSPITIILALFAVGIVAHVLHIM"
     gene            complement(2883..4217)
                     /gene="pepC"
                     /locus_tag="VXE25_001728"
     CDS             complement(2883..4217)
                     /gene="pepC"
                     /locus_tag="VXE25_001728"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000991632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase C"
                     /protein_id="HEV0772153.1"
                     /translation="MNAIQESFTDKLFANYEANVKYQAIENAASHNGIFAALERRQSH
                     VDNTPVFSLDLTKDKVTNQKASGRCWMFAALNTFRHKLISQYKLENFELSQAHTFFWD
                     KYEKSNWFLEQVIATSDQELTSRKVSFLLQTPQQDGGQWDMVVSLFEKYGVVPKSVYP
                     ESVSSSSSRELNAILNKLLRQDAQILRDLLVSGADQATVQAKKEDLLQEIFNFLAMSL
                     GLPPRKFDFAYRDKDNNYKSEKGITPQEFYKKYVNLPLEDYVSVINAPTADKPYGKSY
                     TVEMLGNVVGSRAVRYINVPMERLKELAIAQMQAGETVWFGSDVGQLSNRKAGILATD
                     VYDFESSMDIKLTQDKAGRLDYSESLMTHAMVLTGVDLDENGKSTKWKVENSWGDKVG
                     TDGYFVASDAWMDEYTYQIVVRKELLTAEEQAAYGAEPIVLAPWDPMGALAE"
     gene            complement(4329..5051)
                     /locus_tag="VXE25_001729"
     CDS             complement(4329..5051)
                     /locus_tag="VXE25_001729"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA pseudouridine synthase"
                     /protein_id="HEV0772154.1"
                     /translation="MRLDKFLVACAVGSRTEVKNLLKAGRVTVNGKKEKSAKLQIDEK
                     IDEIRFDGQVLEYEEFVYYMMNKPKGVISATEDPKHRTVLDLLDDLARSKEIFPVGRL
                     DIDTHGLLLLTNDGQLAHVLLSPKRHVDKTYLAQVKGIMTQEDVEIFAEGIPLKDFTC
                     QPAILELVSIDTEKNQSQIRVTIAEGKFHQIKRMVGYCGKEVVDLQRLTMGTLVLDEN
                     LERGEWRRLTKEELEILLASIA"
     gene            complement(5274..5504)
                     /locus_tag="VXE25_001730"
     CDS             complement(5274..5504)
                     /locus_tag="VXE25_001730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000901571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GlsB/YeaQ/YmgE family stress response membrane
                     protein"
                     /protein_id="HEV0772155.1"
                     /translation="MLGSMFVGLLVGFLAGAMTNRGERMGCFGKMFLGWIGAFLGHLL
                     FGTWGPVLSGTAIIPAVLGAMIVLAIFWRRGS"
     gene            complement(5514..6755)
                     /locus_tag="VXE25_001731"
     CDS             complement(5514..6755)
                     /locus_tag="VXE25_001731"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000243957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase"
                     /protein_id="HEV0772156.1"
                     /translation="MVLPNFKENLEKYAKLLVANGINVQPGHTLALSIDVEQRELAHL
                     IVKEAYALGAHEVIVQWTDDVINREKFLHAPMERLDNVPEYKIAEMNYLLENKASRLG
                     VRSSDPGALNGVDADKLSASAKAMGLAMKPMRIATQSNKVSWTVAAAAGLEWAKKVFP
                     NAASDEEAVDFLWDQIFKTCRVYEADPVKAWEEHAAILKSKADMLNKEQFSALHYTAP
                     GTDLTLGLPKNHVWESAGAVNAQGEEFLPNMPTEEVFTAPDFRRADGYVTSTKPLSYN
                     GNIIEGIKVTFKDGQIVDITAEKGDQVMKDLVFENAGARALGECALVPDPSPISQSGI
                     TFFNTLFDENASNHLAIGAAYATSVVDGAEMSEEELEAAGLNRSDVHVDFMIGSNQMD
                     IDGIREDGTRVPLFRNGNWAN"
     gene            complement(6777..6929)
                     /locus_tag="VXE25_001732"
     CDS             complement(6777..6929)
                     /locus_tag="VXE25_001732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000776615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772157.1"
                     /translation="MKLRIFAEDKPAKKVFEYQLELADRTILLSTALLSGAIALAGIF
                     SALKEK"
     gene            complement(6950..7228)
                     /locus_tag="VXE25_001733"
     CDS             complement(6950..7228)
                     /locus_tag="VXE25_001733"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013904578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system YafQ family
                     toxin"
                     /protein_id="HEV0772158.1"
                     /translation="MLKIRYHKQFKKDFKLAMKRGLKAELLEEVLNFLVQEKEHPARY
                     RDHSLTASKHFQGVRECHTQPDWLLVYKVDKSELILNLLRTGSHSDLF"
     gene            complement(7221..7484)
                     /locus_tag="VXE25_001734"
     CDS             complement(7221..7484)
                     /locus_tag="VXE25_001734"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelB/DinJ family
                     antitoxin"
                     /protein_id="HEV0772159.1"
                     /translation="MSKMSMSIRLDSEVKEQAQQVFSNLGMDMTTAINIFLRQAIQYQ
                     GLPFDVRLDENRKLLQVLTDLDQNRNMSQSFESVSDLMEDLRA"
     gene            complement(7586..11977)
                     /locus_tag="VXE25_001735"
     CDS             complement(7586..11977)
                     /locus_tag="VXE25_001735"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000071418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PolC-type DNA polymerase III"
                     /protein_id="HEV0772160.1"
                     /translation="MSNSFEILMNQLGMPAEMRQAPALAQANIERVVVHKISKVWEFH
                     FVFSNILPIEIFLELKKGLSEEFSKTGNKAVFETKARSQEFSNQLLQSYYREAFSEGP
                     CASQGFKSLYQNLQVRAEGNQLFIEGSEAIDKEHFKKNHLPNLAKQLEKFGFPTFNCQ
                     VEKNDVLTQEQEEAFHAENEQIVQAANEEALRAMEQLEQMAPPPAEEKPVFDFQAKKA
                     AAKPKLDKAEITPMIEVTTEENRLVFEGVVFDVEQKVTRTGRVLINFKMTDYTSSFSM
                     QKWVKNEEEAQKFDLIKKNSWLRVRGNVEMNNFTRDLTMNVQDLQEVVHYERKDLMPE
                     GERRVEFHAHTNMSTMDALPEVEEIVATAAKWGHKAVAITDHGNVQSFPHGYKAAKKA
                     GIQLIYGIEANIVEDRVPIVYNEVEMDLSEATYVVFDVETTGLSAIYNDLIQVAASKM
                     YKGNVIAEFDEFINPGHPLSAFTTELTGITDDHVKNAKPLEQVLQEFQEFCKDTVLVA
                     HNAAFDVGFMNANYERHGLPKISQPVIDTLEFARNLYPEYKRHGLGPLTKRFGVALEH
                     HHMANYDAEATGRLLFIFIKEVAEKHGVTDLARLNIDLISPDSYKKARIKHATIYVKN
                     QVGLKNIFKLVSLSNTKYFEGVPRIPRTVLDAHREGLILGSACSEGEVFDVVVSQGVD
                     AAVEVAKYYDFIEVMPPAIYAPLIAKEQVKDMEELQTIIKSLIEVGDRLGKPVLATGN
                     VHYIEPEEEIYREIIVRSLGQGAMINRTIGHGEHAQPAPLPKAHFRTTNEMLDEFAFL
                     GEELARKLVIENTNALAEIFEPVEVVKGDLYTPFINKAEETVAELTYKKAFEIYGNPL
                     PDIVDLRIEKELTSILGNGFAVIYLASQMLVQRSNERGYLVGSRGSVGSSFVATMIGI
                     TEVNPLSPHYVCGQCQYSEFITDGSYGSGFDMPHKDCPNCGHKLSKNGHDIPFETFLG
                     FDGDKVPDIDLNFSGEDQPSAHLDVRDIFGEEYAFRAGTVGTVAAKTAYGFVKGYERD
                     YGKFYRDAEVERLAQGAAGVKRTTGQHPGGIVVIPNYMDVYDFTPVQYPADDVTAEWQ
                     TTHFNFHDIDENVLKLDVLGHDDPTMIRKLQDLSGIDPNKIPMDDEGVMALFSGTDVL
                     GVTPEQIGTPTGMLGIPEFGTNFVRGMVDETHPTTFAELLQLSGLSHGTDVWLGNAQD
                     LIKQGIADLSTVIGCRDDIMVYLMHAGLEPKMAFTIMERVRKGLWLKISEEERNGYIE
                     AMKANKVPEWYIESCGKIKYMFPKAHAAAYVMMALRVAYFKVHHPIYYYCAYFSIRAK
                     AFDIKTMGAGLEAIKRRMEEISEKRKNNEASNVEIDLYTTLEIVNEMWERGFKFGKLD
                     LYRSQATEFLIDGDTLIPPFVAMDGLGENVAKQLVRAREEGEFLSKTELRKRGGLSST
                     LVEKMDEMGILGNMPEDNQLSLFDELF"
BASE COUNT         3340 a         2881 c         2329 g         3510 t
ORIGIN      
        1 acggtttata cttaaacagt cttaaagttt tcttaaatga aaactaaaac aaaaaaggag
       61 gaatgacaat aatgagtatc ggaatcatta ttgcgagcca cggcgaattt gctgcgggta
      121 ttcatcagtc aggatctatg atctttggtg aacaagaaaa ggttcaagtt gtgaccttta
      181 tgccaaatga aggtcctgat gatctatacg ctaagtttaa taacgctgtt gctgcatttg
      241 acgcagaaga tgaggttcta gttttggctg acctttggag tggttctcca tttaaccaag
      301 ctagtcgcgt gatgggagaa aatcctgagc gtaagtttgc catcatcaca ggacttaact
      361 taccgatgtt gattcaagcc tacacagagc gcctcatgga cgctgctgca ggtgtagaaa
      421 aagtcgctgc taatatcatt aaagaagcca aggatggcat caaagctctt ccagaagagc
      481 taaatccagt tgaagaagtt gcaagcgctg cagctgctcc agttgcccaa gctgctatcc
      541 cagaaggaac tgttatcgga gacggtaaat tgaaaatcaa tcttgcccgt cttgacacac
      601 gtctacttca cggtcaggtt gcaactgctt ggactccaga ttcaaaagca aatcgtatca
      661 tcgttgcttc agataacgtg gctaaagacg accttcgtaa agaattgatt aaacaagcag
      721 ctccaggtaa tgtcaaggct aacgtggttc caattcaaaa actgattgag atttcaaaag
      781 acccacgttt tggagaaaca catgccctta tcttgtttga aacacctcaa gatgcccttc
      841 gtgccatcga aggcggcgtg ccaatcaaga ctcttaacgt tggttctatg gctcactcaa
      901 caggtaaaac attggtcaat accgttttgt ctatggacaa agaagatgtt gcgacatttg
      961 aaaaaatgcg tgacttgggt gttgaatttg atgtccgtaa agtaccaaat gattctaaaa
     1021 aagatttgtt tgacttgatt aacaaagcca atgtcaaata agccattatt tatgaaagga
     1081 ttttaaacat gtctattatt tctatggttt tagtagtcgt tgtagccttc tttgcaggtc
     1141 ttgaaggcat cctcgaccag ttccaatttc accaaccact tgtagcctgt acccttattg
     1201 ggcttgtaac aggtcacttg gaagcaggga ttatcctcgg tggatcgctt caaatgattg
     1261 cccttggttg gtcaaatatc ggtgctgcta tcgctcctga tgctgcactt gcttctgtcg
     1321 ctgctgccat tatcatggtt cttggtggtg actttaccaa gactggtatc ggtgttgccc
     1381 aagcggttgc tatccctctt gccgtagctg gacttttctt gacaatgatt gttcgtacaa
     1441 tttcagttgg tttggttcat actgcagatg ctgccgctaa aaaaggtgac ttcggcgctg
     1501 tggagcgtgc gcatttcatt gcgctactct tccaaggact tcgtatcgcg cttcctgcag
     1561 ctcttctcct tatggtacca actgaaactg tacaaagtat ccttagtgcc atgccagact
     1621 ggctcaaaga tggtatggct atcggtggtg gtatggtcgt tgccgttggt tacgccatgg
     1681 ttatcaacat gatggcaact cgtgaagtat ggccattctt cgctcttggt ttcgttctcg
     1741 ctgctgtgtc agatattact ctaatcggat tcggtgctat cggtgttgct atcgctctta
     1801 tctaccttca cctttctaaa actggtggaa atggtggcgg aggagccgca acttctaacg
     1861 acccaatcgg cgatatccta gaagactact aagataagaa aggactgaaa acatcatgac
     1921 tgaaaaactt caattaacta aatcagatcg taaaaaagtt tggtggcgtt caaccttctt
     1981 acaagggtct tggaactttg aacggatgca aaacttgggc tgggcttata cactcattcc
     2041 agctatcaaa aaactctata ctaaaaaaga agatcaaatc gctgctcttg agcgtcacct
     2101 tgagttcttc aacactcatc catacgtagc tgctccagtc atgggggtta ctcttgcgct
     2161 tgaagaagaa cgtgctaacg gtgtggaaat cgatgacgct gctatccaag gggtcaaaat
     2221 cggtatgatg ggacctcttg ctggtatcgg tgacccagta ttctggttta cagtacgccc
     2281 aatccttgga tctctcggtg cttcacttgc ccttactggc aatatcttgg gtccactcct
     2341 cttctttgtt gcatggaact tgattcgtat gtcattcttg tggtatgttc aagagattgg
     2401 atacaaggct ggatcagaaa tcactaaaga tatgtctggt ggtatccttc aagatatcac
     2461 taaaggagct tctatccttg ggatgttcat tcttgctgtc cttgttcaac gctgggtaaa
     2521 tattaaattt gctttcgatg tttctaaagt tcaactagat gaaaaggctt atatccattg
     2581 ggataaattg ccagaagggt ctaaaggtat ccaagaagca ttcgcacaag taggacaagg
     2641 attgtctcaa actcctgaaa aagttactac tttccaacaa aacttggata tgttgattcc
     2701 tggattatca ggactactcc ttactttact ttgcatgtac ttacttaaga aaaaagtatc
     2761 tccaatcact attatccttg ccctcttcgc agtgggtatt gtggcacatg ttcttcacat
     2821 catgtaatca agcaactaaa aaggaaccag gttctaaaat ctgattcctt ttttctatgc
     2881 ttttattcag ccaaggctcc cattggatcc catggtgcaa gtacaattgg ttctgctcca
     2941 taggcagctt gttcttctgc tgtcagcaat tccttacgaa caacgatttg gtatgtgtat
     3001 tcgtccatcc aagcgtctga ggcaacaaag taaccatctg taccgacctt gtctccccat
     3061 gagttttcaa ccttccactt ggttgattta ccattttcgt ccaagtcaac acctgtcaag
     3121 accatggcgt gggtcatcaa gctttcgcta tagtccaaac gtccagcctt gtcttgagta
     3181 agtttaatgt ccatgcttga ttcaaagtca taaacatctg tcgcaaggat gccagcctta
     3241 cggttactga gctggccgac atcagaacca aaccaaacag tctcacctgc ttgcatttgg
     3301 gcaatcgcca attctttcaa gcgctccatt ggaacgttga tgtaacgaac tgcacggcta
     3361 ccaaccacat tccccaacat ctcaactgtg taagattttc cgtaaggttt atcagcagtt
     3421 ggagcattga taacagaaac gtagtcttct aaaggaagat tgacatattt cttgtaaaac
     3481 tcttgtggtg tgattccttt ttcacttttg tagttgttat ctttatcgcg ataagcaaag
     3541 tcaaacttgc gtggtggaag tcctaatgac atagcaagaa agttaaagat ttcttgcaag
     3601 aggtcttctt tcttagcttg aacagtcgct tgatctgcac cagaaacaag caagtcacgc
     3661 aagatttgag catcttgacg aagcaattta ttaaggatcg catttagctc acgactgctg
     3721 ctagatgaaa cagactcagg ataaactgac ttaggcacga caccgtattt ttcaaagagg
     3781 gaaacgacca tatcccattg accaccatct tgttgaggtg tttgaagtaa gaagctaacc
     3841 ttgcggctag tcaattcttg gtctgaagtc gcaatgactt gctccaagaa ccagtttgat
     3901 ttctcatact tatcccagaa gaaagtgtgg gcttgtgaca actcaaagtt ctccaatttg
     3961 tattgcgaga tgagtttgtg gcggaaggtg ttgagagccg caaacatcca gcaacgacca
     4021 gacgctttct ggttagtgac cttgtccttg gttaaatcca atgagaaaac aggtgtgttg
     4081 tctacatggc tttggcgacg ttccagagct gcaaaaattc cgttgtggct agcagcattt
     4141 tcaatcgctt ggtattttac atttgcttca tagttggcaa atagtttatc agtaaatgat
     4201 tcttgaatcg cgttcataga ttcctccttt tattctacag tctattataa ctcttttcac
     4261 aaaggaagca actaaaaaac ataaaaggta aggacattct ccctcacctt tttcgaatat
     4321 aaatcaaatt aagcaatact agcaaggaga atttctaatt cttccttggt caagcgacgc
     4381 cattcccctc gttccaggtt ctcatctaat actaaagttc ccatagtcaa tcgttgcaag
     4441 tccaccactt ccttgccaca gtagcccacc atacgcttga tctgatgaaa cttcccttct
     4501 gcaatggtca cacggatttg gctttgattc ttttctgtat ctatggatac aagctccagt
     4561 atagcgggtt gacaggtaaa gtctttgaga ggaataccct cagcaaatat ctccacatct
     4621 tcttgggtca tgattccctt gacttgtgcc agataagtct tgtccacatg acgcttgggc
     4681 gaaagaagaa catgagccag ctgaccatca ttggtcaaga gcaaaagacc atgcgtgtca
     4741 atatccaagc gtcctactgg gaaaatttcc ttactccgcg ccaagtcatc caacaagtcc
     4801 agaacggttc tgtgcttggg atcctcagtc gctgatataa ctcctttggg cttgttcatc
     4861 atgtagtaga caaactcttc atactccaac acttgcccat caaagcgaat ctcatctatt
     4921 ttttcatcaa tctgcaattt agctgatttt tcttttttac catttacagt cacgcgccca
     4981 gccttgagca agtttttgac ctcagtccga cttcccaccg cacaggcaac taaaaattta
     5041 tctaatctca tagaactatt atatcatatc aaaaggaggc tggtacaatg accaacctcc
     5101 ttttcgtttc atactcttca aaaatctctt caaaccgcgt caacgtcgcc ttgccgtata
     5161 tatgttactg acttcgtcag ttctatctgc aacctcaaag cagtgctttg agcaacctgc
     5221 ggctagtttc ctagtttgct ctttgatttt cattgagtat cagatttaag aaattaactt
     5281 cctcgtctcc aaaaaatagc taagacaatc atggcaccta aaacagctgg gataatagct
     5341 gttcctgata aaactggccc ccaagttcca aagagcaagt gacctagaaa ggctccgatc
     5401 caaccgagaa acatttttcc aaaacatccc attcgctctc cacgattggt catagcacct
     5461 gctaaaaatc ccactaggag accaacgaac atacttccta acatattatc tccttaattt
     5521 gcccaattcc cattacggaa aagaggtact cgcgttccat cctcacgaat accatcgata
     5581 tccatttggt tagaaccaat cataaagtct acgtgaacat ctgaacggtt aagccctgca
     5641 gcttcaagct cctcttcgct catctccgct ccatcaacaa cgctagtcgc ataggctgca
     5701 ccgatagcca agtggtttga cgcattttca tcgaaaaggg tgttaaagaa ggtaatgcct
     5761 gactgagaaa ttggacttgg atctggtacc aaggcacatt cacccaaggc acgcgcaccc
     5821 gcattttcaa agacaaggtc tttcataacc tgatcaccct tctcagcagt gatatctacg
     5881 atttgtccat ccttaaaggt caccttaatg ccttcaatga tatttccgtt gtagctaagc
     5941 ggttttgtag aagtgacata accatctgca cgacggaagt caggcgctgt gaagacctct
     6001 tctgtcggca tatttggcaa gaattcttcg ccctgtgcat tgacagcacc agctgattcc
     6061 caaacgtggt tctttggcaa accaagtgtt aaatctgttc ctggcgctgt gtagtgaagg
     6121 gctgaaaatt gctccttatt aagcatatcg gccttgctct tgagaatggc tgcatgttcc
     6181 tcccaagcct taacaggatc tgcttcgtag acacggcaag ttttgaaaat ttggtcccaa
     6241 aggaaatcaa ctgcttcttc gtcgctcgca gcatttggga agactttctt agcccactca
     6301 agtcctgctg cagctgctac agtccagcta actttgttag attgagttgc gattcgcatt
     6361 ggcttcatgg caagtcccat agctttagca gaagctgaaa gcttgtcagc gtccactccg
     6421 ttcaaggcac ctggatcaga tgaacgaact ccaagacggc tagccttgtt ctccaagaga
     6481 tagttcatct cagcaatctt gtattctggc acattgtcca aacgctccat cggggcatgg
     6541 aggaatttct cacggttaat cacatcatct gtccactgaa cgatgacctc atgcgcaccc
     6601 aaggcataag cttctttcac gattagatgt gccaattcac gttgctccac atcaatagag
     6661 agagccaaag tgtgaccagg ttgcacgtta attccgttcg caaccaacaa tttcgcatat
     6721 ttttctagat tttctttaaa atttggtaaa accatcctgt tttctctttt ctatttttat
     6781 ttttctttca aagcagaaaa gattcctgct aaagcaatag cacctgacaa gagtgctgtc
     6841 gatagaagaa ttgtacgatc agcaagttct aattgatatt caaatacctt cttagccggc
     6901 ttatcttccg caaatattct tagtttcatg agaaccccct taaaatagat taaaataaat
     6961 cactgtgact gcctgtcctc agcaaattta aaatcaattc cgacttatct actttataaa
     7021 ccaaaagcca atctggctgg gtatggcatt cacgaactcc ttgaaaatgc ttggatgccg
     7081 tcaatgaatg atcacgatat ctggcaggat gttctttttc ttgaaccaga aaattcaaaa
     7141 cttcttctaa taattctgcc ttcaaaccac gcttcatagc caacttaaaa tcttttttaa
     7201 actgtttatg ataacgaatc ttaagcacgt aagtcctcca tcaaatctga gactgattca
     7261 aaagactggc tcatattacg attttggtct aaatccgtta acacttggag caacttccga
     7321 ttttcgtcta gtctaacatc aaaaggtaat ccctgatatt gaattgcctg acgaaggaaa
     7381 atattaatag ctgttgtcat atccattccc agattactaa acacctgttg ggcctgctcc
     7441 ttaacctcac tatccagacg gatgctcata ctcatctttg acatactctc accctctttc
     7501 catagactat tttaacaaaa aagaaagcta atgtaaatct attggatata cgttagcctc
     7561 ttctaataga ttattaagca attttttaaa acaactcatc aaacaaactc aactggttat
     7621 cctctggcat atttccaaga atacccatct catccatctt ttcaaccaag gttgatgaga
     7681 gtccaccacg cttgcgtagt tctgttttag agaggaattc tccctcttca cgcgcccgca
     7741 ccagttgctt ggcaacgttc tctcccagac catccattgc tacaaatggt gggataaggg
     7801 tatccccgtc gatgaggaac tctgtcgcct gactacggta gagatctaat ttgccaaact
     7861 tgaaacctcg ttcccacatc tcattgacaa tctcaagagt tgtatagaga tcgatttcca
     7921 cattagaggc ttcattgttc ttccgttttt cagagatttc ttccattctg cgcttgatgg
     7981 cctccaagcc cgcacccatg gtcttgatat caaaagcctt agcacgaatg gagaagtaag
     8041 cacagtagta ataaatagga tggtgaacct tgaagtaagc tacacgcaag gccatcataa
     8101 cgtaggctgc cgcatgggcc ttagggaaca tgtacttaat tttcccacag gattcgatat
     8161 accactctgg caccttatta gccttcatgg cttcgatata gccatttctc tcctcttctg
     8221 aaatctttag ccacaaaccc ttacgtaccc gttccataat ggtaaaggcc atcttaggtt
     8281 ccagacccgc atgcatgagg taaaccatga tgtcgtcccg acaaccgata acagtcgata
     8341 ggtccgctat tccttgctta atcagatcct gagcattccc caaccaaacg tcagtaccgt
     8401 gggacagacc agacagctga agcaattccg caaaggttgt cggatgggtt tcgtctacca
     8461 ttccacgtac gaaatttgtt ccaaactctg gaatccccaa catacccgta ggcgttccaa
     8521 tttgttcagg tgttacccct agcacatcag tcccagaaaa gagtgccatc acgccttcgt
     8581 catccatagg aattttatta gggtcaatac cagacaaatc ctgaagtttt cgaatcatgg
     8641 tcggatcatc atgtcccagt acatcgagtt tgaggacgtt ctcatcgata tcgtggaagt
     8701 taaagtgagt ggtctgccat tcagccgtga catcatctgc tggatactgg acaggcgtaa
     8761 aatcgtagac atccatgtag ttcggaataa caacgattcc ccccgggtgt tggcctgttg
     8821 tccgcttgac acccgccgct ccttgagcga ggcgttctac ttctgcatca cgataaaact
     8881 tgccataatc tcgctcgtaa cccttgacaa atccataggc agtcttggca gctaccgtac
     8941 caaccgttcc cgcacggaag gcatattctt caccaaagat atcacgcaca tccaagtggg
     9001 cgctaggctg atcttctccc gagaagttca agtcaatatc aggaacctta tccccatcaa
     9061 aaccaaggaa ggtctcaaac ggaatatcat gtccgttttt actgagtttg tgaccacagt
     9121 ttggacagtc cttatggggc atatcaaatc ctgaaccgta cgaaccatct gtgataaact
     9181 cactgtactg acactgacca cagacatagt gaggagagag aggattgacc tccgtaatcc
     9241 caatcatggt cgcaacgaaa ctagatccga cagacccacg agaaccaacc aaataacccc
     9301 gttcattaga acgttgcacc agcatctgcg atgccagata aatcacagca aatccattcc
     9361 ccagtatgga tgttaattct ttttcaatcc gcaaatcaac aatatctggc agcggatttc
     9421 cataaatctc aaaagctttc ttataggtca actcagcaac tgtttcttca gccttgttga
     9481 tgaaaggcgt atacaagtca cccttaacga cttcaacggg ttcaaatatt tctgccaagg
     9541 cattagtgtt ttcaataacc agtttacgag ccagttcctc tcccaaaaag gcaaattcat
     9601 ccaacatctc attagtcgtt cgaaaatgag cctttggaag tggcgctggt tgggcatgtt
     9661 caccatgacc gatagttcgg ttaatcatcg caccctgtcc caaactacgg acgataattt
     9721 cacgataaat ctcttcttcc ggttcgatat agtgaacatt tcccgtagcc agaacaggct
     9781 tgccaaggcg atctccaacc tctatcaaac tcttgataat ggtctggagt tcctccatat
     9841 ccttgacctg ctctttggca atcaagggcg catagatagc cggtggcatg acctcgataa
     9901 agtcataata cttggccacc tcaaccgccg catccacacc ttgagaaacg accacgtcaa
     9961 aaacttcacc ctctgaacag gctgaaccta aaatcaagcc ctctcgatgg gcatctagaa
    10021 ccgttctcgg aatccgtggc actccttcaa aatacttggt attagacaag gaaaccagct
    10081 taaagatatt ttttagacct acctgattct tgacatagat ggtcgcatgc ttgatccgag
    10141 cttttttgta agaatctgga ctgattagat caatgttgag tctagctaaa tcggtcacac
    10201 catgtttttc tgctacctct ttgataaaga tgaaaagcag acgaccagtc gcttccgcat
    10261 cgtagttggc catgtggtga tgttccaagg ccacaccaaa acgcttggtc aaaggcccca
    10321 aaccatggcg tttatactca ggatagaggt ttctagcaaa ctccagcgta tcaataactg
    10381 gctgactaat ctttggaaga ccatgacgct cataattagc attcataaag ccaacgtcaa
    10441 aggcagcatt gtgggcaact aggaccgtat ccttgcaaaa ttcttggaat tcttgcaaaa
    10501 cttgttctag tggtttggca tttttgacat gatcatctgt aattccagtt aactctgtag
    10561 taaaagctga caagggatgc ccaggattga taaattcatc aaattcagca ataacattcc
    10621 ccttgtacat cttagaggcc gcaacctgaa tcaagtcatt atagatagct gaaagtcccg
    10681 tcgtttccac gtcaaagacc acgtaggttg cttctgataa gtccatctcc acttcgttat
    10741 agacgatagg gacacggtcc tccacgatat tggcttctat cccatagatc agctggattc
    10801 ccgctttctt agccgcctta tagccatgtg gaaaggactg gacattccca tggtctgtga
    10861 tagcaaccgc cttgtgtccc cacttagcag ctgttgcaac aatctcttcg acctctggca
    10921 aagcatccat agtcgacatg ttagtatgag catgaaactc aacccgacgc tcaccttctg
    10981 gcatcaaatc cttccgctca tagtgaacaa cttcctgcag atcctgtacg ttcatagtca
    11041 aatcgcgtgt gaagttattc atctccacat tccctcgaac tcggagccaa gaattcttct
    11101 tgatgaggtc aaacttctgg gcctcttcct cgtttttaac ccacttttgc atagaaaaac
    11161 ttgaagtata gtccgtcatt ttaaagttga ttaaaacacg acctgttcta gtcacttttt
    11221 gctccacatc aaaaacaacc ccttcaaata ccagacgatt ttcctctgtc gtcacttcga
    11281 tcataggagt aatctccgcc ttatccagct tgggtttagc tgcagctttt ttcgcttgaa
    11341 aatcaaagac tggtttctct tccgctggag gaggtgccat ctgctccagt tgttccatag
    11401 cacggagcgc ttcctcattg gcagcttgaa caatctgctc attttcagca tgaaaggcct
    11461 cttcctgctc ttgggtcagg acatcattct tctcgacttg acagttaaaa gttggaaaac
    11521 caaacttttc aagttgtttg gctaaattag gaagatgatt cttcttaaaa tgttccttat
    11581 caatcgcttc agatccttca ataaatagct gattaccctc agcacgaact tgcaaatttt
    11641 gataaaggga cttaaaacct tgactagcac atggaccttc agagaaagcc tccctatagt
    11701 aggactgcaa gagctgattt gaaaattctt gagaccgagc cttagtttca aaaacagctt
    11761 tattgcctgt cttagaaaat tcttcgctca aacctttctt taattctaaa aagatttcaa
    11821 tcggtaaaat attagaaaat acgaaatgaa actcccatac cttactaatt ttatgaacca
    11881 caactcgctc aatattggcc tgtgctaaag caggagcctg tctcatttca gcaggcatcc
    11941 ccaattgatt catcaaaatt tcaaaactat ttgacattca ttttcctcac attattcttc
    12001 tactatttta ccatatttag aggtattttc ggctctataa tatttgtagt gggtaaatcc
//
LOCUS       DAVLHC010000051        11959 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.052, whole genome shotgun sequence.
ACCESSION   DAVLHC010000051 DAVLHC010000000
VERSION     DAVLHC010000051.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 11959)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11959)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11959
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.052"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(54..1103)
                     /locus_tag="VXE25_001736"
     CDS             complement(54..1103)
                     /locus_tag="VXE25_001736"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000229779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="HEV0772161.1"
                     /translation="MVELGISTFGEITELEGTGQTYSHAERIRQLVAEIELADKIGLD
                     VYGIGEHHRADFAVSAPEIVLAAGAVNTKKIRLTSAVSILSSMDPIRLFQQYATIDAL
                     SNGRSEIMAGRGSFTESFPLFGYDLKDYDSLFDEKLDLLQLVNEKTKLDWQGRLTQTI
                     AGKEVYPRPVQDKLPLWIATGGHVESTVKIAQAGLPIVYAIIGGNPRYFKKLIQAYRE
                     IGSEAGHADKDLKVGAHSWGWIAEDGEQAVKDYFHPTKQVVDAISKDRPHWQELRYEQ
                     YLEQVGPNGAMFVGNPDQVAEKLIRMIEDLGLDRFMLHLPLGSMPHDQVLRAIELFGT
                     QVAPKVRAYFAMKEA"
     gene            complement(1223..3031)
                     /gene="glmS"
                     /locus_tag="VXE25_001737"
     CDS             complement(1223..3031)
                     /gene="glmS"
                     /locus_tag="VXE25_001737"
                     /EC_number="2.6.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014621492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine--fructose-6-phosphate transaminase
                     (isomerizing)"
                     /protein_id="HEV0772162.1"
                     /translation="MCGIVGVVGNTNATDILIQGLEKLEYRGYDSAGIFVLDGADNHL
                     VKAVGRIAELSAKTAGVEGTTGIGHTRWATHGKPTEDNAHPHRSETERFVLVHNGVIE
                     NYLEIKEEYLAGHHFKGQTDTEIAVHLIGKFAEEDGLSVLEAFKKALHIIRGSYAFAL
                     IDSENPDVIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETNQYMEIHDQELVIVKADS
                     VEVQDYDGNSRERASYTAELDLSDIGKGTYPYYMLKEIDEQPTVMRKLIQAYTDDAGQ
                     VVIDPAIIKAVQDADRIYILAAGTSYHAGFASKKMLEELTDTPVELGISSEWGYGMPL
                     LSKKPLFIFISQSGETADSRQVLVKANEMGIPSLTVTNVPGSTLSREANYTMLLHAGP
                     EIAVASTKAYTAQIAALAFLAKAVGEANGNAKAQAFDLVHELSIVAQSIESTLSEKET
                     IEAKVRELLETTRNAFYIGRGQDYYVAMEASLKLKEISYIQCEGFAAGELKHGTIALI
                     EEGTPVLSLLSDPVLANHTRGNIQEVAARGAKVLTIAEENVAKDTDDIVLTTVHPYLS
                     PISMVVPTQLVAYFATLHRGLDVDKPRNLAKSVTVE"
     gene            complement(3223..4602)
                     /gene="bglA"
                     /locus_tag="VXE25_001738"
     CDS             complement(3223..4602)
                     /gene="bglA"
                     /locus_tag="VXE25_001738"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000943526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="HEV0772163.1"
                     /translation="MLRFPKDFVWGSSTSGPQTEGRVAGDGKGDNLWDYWFQVEPNRY
                     YNGIGSDKTSTFYENWERDIELLLETGHTAFRTSIQWSRIFPQGCGKVNPQGVDFYRK
                     VFEAIKAKGIRLLVNLYHFDLPFALQEDGDGWENKATVSAYEDYARFCFETYGDLVDQ
                     WITFNEPIVPVEFGYFYDAHYPHKVDAEAAVKVAYHTQLASSRAVKACHELLPDSKIG
                     IVLNLTPAYPRSQHPADVKAARIAALFQAQSFLDPSVLGTYPQELVEILHEHGLLPDA
                     TEEELELIRDNTVDFLGVNYYQPLRVMAPRFAKHPDSPLLPEHFYEPYVMPGRKINSH
                     RGWEIYEQGIYDIAQNIKENYDNIEWMLTENGMGVEGEEKFRQDGMIQDDYRIDFVKG
                     HLRELHRAIEDGANCKGYLIWTFIDCWSWLNSYKNRYGLVELDLETQERRLKKSGHWF
                     KELSDNNGF"
     gene            complement(4701..6554)
                     /locus_tag="VXE25_001739"
     CDS             complement(4701..6554)
                     /locus_tag="VXE25_001739"
                     /EC_number="6.1.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000814078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline--tRNA ligase"
                     /protein_id="HEV0772164.1"
                     /translation="MKQSKMPIPTLREMPSDAQVISHALMLRAGYVRQVSAGVYSYLP
                     LANRVIEKAKNIMRQEFEKIGAVEMLAPALLSAELWRESGRYETYGEDLYKLKNREKS
                     DFILGPTHEETFTAIVRDSVKSYKQLPLNLYQIQPKYRDEKRPRNGLLRTREFIMKDA
                     YSFHANYDSLDSVYDEYKAAYERIFTRSGLDFKAIIGDGGAMGGKDSQEFMAITSART
                     DLDRWVVLDKSVASFDEIPAEVQEEIKAELLKWIVSGEDTIAYSSESSYAANLEMATN
                     EYKPSNRVVAEEEVTRVATPDVKSIDEVAAFLNVPEEQTIKTLFYIADGELVAALLVG
                     SDQLNEVKLKNHLGADFFDVASEEEVANVVQAGFGSLGPVGLPENIKIIADRKVQDVR
                     NAVVGANEDGYHLTGVNPGRDFTAEYVDIREVREGEISPDGQGVLNFARGIEIGHIFK
                     LGTRYSASMGADVLDENGRAVPIIMGCYGIGVSRLLSAVMEQHARLFVNKTPKGEYRY
                     AWGINFPKELAPFDVHLITVNVKDEEAQALTEKLEASLMGAGYEVLTDDRNERVGVKF
                     SDSDLIGLPIRITVGKKAADGIVEVKIKATGDTIEVHADNVLETLEILSKK"
     gene            complement(6567..7826)
                     /gene="rseP"
                     /locus_tag="VXE25_001740"
     CDS             complement(6567..7826)
                     /gene="rseP"
                     /locus_tag="VXE25_001740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000900658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RIP metalloprotease RseP"
                     /protein_id="HEV0772165.1"
                     /translation="MLGILTFILVFGIIVVVHEFGHFYFAKKSGILVREFAIGMGPKI
                     FAHIGKDGTAYTIRILPLGGYVRMAGWGDDTTEIKTGTPVSLTLADDGKVKRINLSGK
                     KLDQTALPMQVTQFDFEDKLFIKGLVLEEEKTFAVDHDATVVEADGTEVRIAPLDVQY
                     QNATIWGKLITNFAGPMNNFILGVVVFWVLIFMQGGVRDVDTNQFHIMPQGALAKVGV
                     PETAQITKIGSHEVSNWESLIQAVETETKDKTAPTLDVTISEKGSDKQVTVTPEDSQG
                     RYLLGVQPGVKSDFLSMFVGGFTTAADSALRILSALKNLIFQPDLNKLGGPVAIFKAS
                     SDAAKNGIENILYFLAMISINIGIFNLIPIPALDGGKIVLNILEAIRRKPLKQEIETY
                     VTLAGVVIMVVLMIAVTWNDIMRLFFR"
     gene            complement(7848..8651)
                     /locus_tag="VXE25_001741"
     CDS             complement(7848..8651)
                     /locus_tag="VXE25_001741"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000189872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatidate cytidylyltransferase"
                     /protein_id="HEV0772166.1"
                     /translation="MTQDLQKRTLFAGIALAIFLPILMIGGLLLQIAIGIIAMLAMHE
                     LLKMRGLETMTMEGLLTLFATFALTIPLENYLTFLPVDGNVVAYSVLISIMLGTTVFS
                     KSYTIEDAVFPLAMSFYVGFGFNALLDARVAGLDKALLALCIVWATDSGAYLVGMNYG
                     KRKLAPRVSPNKTLEGALGGILGAILVTIIFMIVDSTVALPYGIYKMSVFAIFFSIAG
                     QFGDLLESSIKRHFGVKDSGKFIPGHGGVLDRFDSMLLVFPIMHLFGLF"
     gene            complement(8660..9418)
                     /locus_tag="VXE25_001742"
     CDS             complement(8660..9418)
                     /locus_tag="VXE25_001742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000466694.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isoprenyl transferase"
                     /protein_id="HEV0772167.1"
                     /translation="MFGFFKKDKAVEVEVPTQVPAHIGIIMDGNGRWAKKRMQPRVFG
                     HKAGMEALQTVTKAANKLGVKVITVYAFSTENWTRPDQEVKFIMNLPVEFYDNYVPEL
                     HANNVKIQMIGETDRLPKQTFEALTKAEELTKNNTGLILNFALNYGGRAEITQALKLI
                     SQDVLDAKINPGDITEELIGNYLFTQHLPKDLRDPDLIIRTSGELRLSNFLPWQGAYS
                     ELYFTDTLWPDFDEAALQEAILAYNRRHRRFGGV"
     gene            complement(9649..10113)
                     /locus_tag="VXE25_001743"
     CDS             complement(9649..10113)
                     /locus_tag="VXE25_001743"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000718819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase family protein"
                     /protein_id="HEV0772168.1"
                     /translation="MAAGSVRNFIWNLLSDKSPFDHETDIDVIFFDPDFSYEETLLLE
                     KKLREDFPQYQWELKNQVYMHQHSPHTAFYTSSRDAMSKYPERCTAVGLRLNEESDFE
                     LYAPYGLEDILNFQVRPTPHFLENEDRMELYQTRLSKKNWQEKWKNLIFKNT"
     gene            complement(10202..11173)
                     /gene="ruvB"
                     /locus_tag="VXE25_001744"
     CDS             complement(10202..11173)
                     /gene="ruvB"
                     /locus_tag="VXE25_001744"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000502070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction branch migration DNA helicase
                     RuvB"
                     /protein_id="HEV0772169.1"
                     /translation="MGDEELVERTLRPQYLREYIGQDKVKDQLQIFIEAAKMRDEALD
                     HVLLFGPPGLGKTTMAFVIANELGVNLKQTSGPVIEKAGDLVAILNELEPGDVLFIDE
                     IHRLPMSVEEVLYSAMEDFYIDIMIGAGEGSRSVHLELPPFTLIGATTRAGMLSNPLR
                     ARFGITGHMEYYAHADLTEIVERTADIFEMEITHEAASELALRSRGTPRIANRLLKRV
                     RDFAQIMGNGVIDDIITDKALTMLDVDHEGLDYVDQKILRTMIEMYSGGPVGLGTLSV
                     NIAEERETVEDMYEPYLIQKGFIMRTRSGRVATAKAYEHLGYEYSEK"
     gene            11334..11426
                     /locus_tag="VXE25_001745"
     CDS             11334..11426
                     /locus_tag="VXE25_001745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="HEV0772170.1"
                     /translation="MMELVLKTIIGPIVVGVVLRIVDKWLNKDK"
BASE COUNT         3503 a         2818 c         2250 g         3388 t
ORIGIN      
        1 attaattttc gtacaatatt tgttgtccta ataaacttga ttaggatttt ttattaagcc
       61 tctttcatag caaaataagc tcgtactttg ggtgcaactt gtgttccgaa gagttcaata
      121 gctctcagaa cctggtcatg aggcatagaa ccaagcggta gatgaagcat gaagcggtcc
      181 aatcctaaat cctctatcat gcgaatcaat ttttcggcca cctgatctgg attgccaaca
      241 aacatggcgc catttggccc tacctgctcc aaatattgct cataacgcaa ttcctgccag
      301 tgcggacggt ctttggaaat agcatccact acttgcttag tcggatggaa ataatctttc
      361 accgcctgct caccatcttc cgcaatccac ccccaagaat gggctcccac tttcaagtct
      421 ttgtcagcat ggcccgcttc gcttccaatc tcacgataag cctgaatcaa ctttttaaaa
      481 taacgtggat taccaccaat aatagcatat acaatcggta gaccagcctg agcaatcttc
      541 actgttgatt cgacatgacc acctgtagct atccacaagg gcaatttgtc ctgaactgga
      601 cgaggataaa cttctttacc agcaatcgtt tgagtcaatc gaccttgcca gtctaacttg
      661 gtcttttcat tgactaactg aagcaagtct aatttctcat caaaaagaga gtcgtagtct
      721 ttcaagtcat aaccaaacag agggaaagat tccgtgaaag agccccttcc agccataatc
      781 tccgatcgtc catttgacaa agcatcgata gtggcatact gttggaacaa acgaatcgga
      841 tccatgcttg acagaatgct gactgcactg gtcaaacgga ttttcttggt attgactgcc
      901 ccagcggcca ggacaatctc tggggctgat actgcaaaat ccgcccgatg gtgctcgcca
      961 atcccatata cgtccaaacc aatcttgtca gccagctcaa tctctgccac caactggcga
     1021 atgcgttcag catgactgta agtttgtcca gtcccttcaa gctccgttat ttccccaaat
     1081 gttgaaattc ccaattctac cattgtgatt ctccttgtct atctctgtcc ttcaatttga
     1141 aaaattattc taacacgaat cttaagtaca agcaaccaat ttgctcacaa gaaaaaggcc
     1201 tagataacta gactttttta gcttattcta ccgttactga cttggcaagg ttacgtggtt
     1261 tgtccacatc gaggccacgg tggagggttg caaagtaagc gactaattgc gttggtacga
     1321 ccattgaaat tggtgagagg tatggatgta cggtcgtaag gacgatatcg tcggtatctt
     1381 tggctacatt ctcttctgcg atagtgagga ctttggcacc acgggctgcg acctcttgga
     1441 tatttccacg agtatggttg gcaagaactg gatctgacaa gagagacaag acaggcgttc
     1501 cttcttcaat caaggcaatg gttccgtgct tgagttctcc tgccgcaaaa ccttcacact
     1561 ggatataaga aatctctttg agtttgagac ttgcttccat ggctacgtag taatcttgac
     1621 cacgtccgat gtaaaaggcg ttacgagttg tttcaagaag ttcacgaacc ttggcttcaa
     1681 tggtttcttt ctctgaaaga gttgattcga tagactgagc tacgattgac aattcatgaa
     1741 ccaggtcaaa ggcttgcgct ttagcattac catttgcttc tccgactgct tttgcaagga
     1801 aggcaagggc tgcgatttgc gctgtatagg ctttagttga tgccacggca atttcaggac
     1861 ctgcgtgaag gagcatggta tagttggctt cacgtgagag ggttgaacct ggaacgtttg
     1921 tcactgttaa gcttggaatt cccatttcat tagccttgac caaaacttga cgactatccg
     1981 ctgtttcacc agattggctg ataaagatga agagtggttt cttgctgaga agtggcatac
     2041 cgtagcccca ctcagatgag attccaagtt caactggtgt atctgtcaat tcttccaaca
     2101 ttttcttaga agcaaatcct gcatggtaag atgttccagc tgcaaggatg tagatgcggt
     2161 ctgcgtcttg aacagcctta atgatagcag gatcaatcac tacttgacca gcatcatccg
     2221 tgtaggcttg aatgagttta cgcataacag ttggttgctc atcaatttcc ttaagcatgt
     2281 agtaaggata agttccctta ccgatatctg acaagtcaag ttccgcagta tagctagcac
     2341 gttcacgact gttaccatca tagtcttgaa cttccacgct atcagccttg acgattacca
     2401 actcttggtc atgaatttcc atgtattggt tggtttcacg aatcatagcc atagcatctg
     2461 agcagaccat attgtagcct tccccaagac caatcaaaag tggagatttg tttttcgcta
     2521 catagatgac atctggattt tcagagtcaa tcaaggcaaa ggcatatgaa ccacggataa
     2581 tatgaagagc ttttttaaag gcttcaagaa ctgagagacc gtcttcttcc gcaaattttc
     2641 caatcaaatg tacggcgatt tccgtatctg tttgcccttt gaagtggtgc ccagcaaggt
     2701 attcttcttt aatttcaagg tagttttcaa tcaccccatt gtgaaccaag acaaaacgtt
     2761 ctgtctcaga gcggtgtggg tgagcattgt cttccgttgg tttcccatga gttgcccaac
     2821 gagtatgtcc gataccagtt gttccctcaa caccagctgt cttggcagac aattctgcga
     2881 tacgaccaac agccttcacc aaatggttat cagcaccatc taggacaaaa attcccgcag
     2941 aatcatagcc acggtattca agcttttcaa gcccttgaat caaaatatca gttgcatttg
     3001 tgtttccaac aacaccaaca attccacaca tagtatatac gacacaggca agctgtgctt
     3061 tctccttaaa attggtatag tctaattcat cttttataga atcagcaaaa acagtatata
     3121 cttgtttctt tcacttgtca agagtaaaaa ttggtatagt tcaaattaag ctcctgtaag
     3181 caaaaaactc tgaccgattg ggataatcag tcagagtcct ttttaaaatc cattattatc
     3241 gcttaattct ttgaaccagt ggcctgattt cttcagacga cgttcttgcg tttccaagtc
     3301 taattcgacc aaaccatagc gatttttata gctgttgagc catgaccagc agtcaataaa
     3361 ggtccaaatc aagtagccct tacagttggc accatcttca atggcacggt gaagttcacg
     3421 aagatgacct tttacaaagt caatacggta atcatcttga atcattccat cttgacggaa
     3481 tttttcttcc ccttcaacac ccataccatt ctcagtcaac atccattcaa tattgtcata
     3541 attttccttg atattttggg cgatgtcata aatcccttgc tcataaatct cccaaccacg
     3601 gtgagaattg attttacgtc caggcatcac ataaggctcg taaaaatgtt ctggtaagag
     3661 tggactatct ggatgcttag caaatcgagg agccataaca cgcaaaggtt gatagtagtt
     3721 cacaccaagg aagtccaccg tattatcacg aatgagttcc aactcttcct ctgtagcatc
     3781 aggtaaaaga ccgtgttcat gcaagatttc taccaactcc tgtggataag tccccaagac
     3841 agatggatct aagaaagatt gggcctgaaa aagggccgca atacgagctg ccttgacatc
     3901 agcaggatgc tggctacgtg gataagccgg tgtcaagttg aggacaatcc caatcttgga
     3961 atcaggcaaa agttcatggc aagccttaac agcccggctg ctggccaatt gtgtatgata
     4021 ggctacctta acagctgcct ctgcatccac cttatgtgga taatgggcat cataaaaata
     4081 accaaattct acaggaacga tgggctcgtt aaaggtaatc cattgatcca ctaaatctcc
     4141 ataagtctca aaacaaaaac gagcatagtc ttcataggct gagactgtcg ccttattttc
     4201 ccaaccatca ccatcctctt gaagggcaaa aggtaaatca aaatgataga gattgactaa
     4261 cagacgaatt cctttagcct taatagcctc aaagacctta cgataaaaat ccacaccttg
     4321 agggttgact tttccacagc cttgtggaaa aatccgtgac cactgaatag aagtccgaaa
     4381 ggctgtgtga ccagtctcta acaaaagctc aatatcccgc tcccaatttt cataaaaagt
     4441 cgatgtctta tctgaaccaa tcccattata gtaacgattt ggctccactt ggaaccagta
     4501 atcccagaga ttgtctccct taccgtcacc agctacacgt ccttctgtct gcggtccaga
     4561 agtagaggat ccccagacaa aatcctttgg aaatcttagc atacatttac ctctttatct
     4621 actcatttct cccattatac agaaaaaaca aggtaaaaac tagttacatt ttttccttgt
     4681 ttttcttctg attatagttt ttatttcttg cttaggattt caagcgtttc aagcacgtta
     4741 tctgcatgaa cctcaatggt gtcaccagtt gccttgatct taacttctac aatgccatcg
     4801 gccgcttttt taccaacagt gatacggatt ggaagaccaa tcaagtcact atcgctaaat
     4861 ttaacaccga cacgttcgtt acggtcatct gtcaagactt cataaccagc tcccatcaag
     4921 cttgcttcaa gtttttctgt caaggcttgc gcttcttcat ccttgacatt aacagtaatc
     4981 aaatgcacat caaacggtgc caattcttta gggaaattga ttccccaagc gtaacggtat
     5041 tcaccttttg gcgttttgtt aacaaagagg cgagcgtgtt gctccatcac tgctgaaaga
     5101 agacggctga caccgatacc gtaacatccc atgatgattg gcacagcacg accattttca
     5161 tccaagacat ctgctcccat gcttgctgaa tagcgagttc cgagtttgaa aatatgaccg
     5221 atctcaatac cacgcgcaaa gttaaggaca ccttgtccat ctggggaaat ttcaccctca
     5281 cgaacttcac ggatatccac atattctgca gtaaaatcac ggcctgggtt cacaccagtc
     5341 aagtggtagc catcttcgtt agcaccgaca actgcattgc gaacatcttg caccttacga
     5401 tctgcaataa ttttaatatt ctctggcaaa ccaactggtc caagtgaacc aaatcctgct
     5461 tgaacaacat tcgccacttc ttcttcgcta gcaacgtcaa agaaatctgc tcccaagtga
     5521 tttttcaact tgacttcgtt gagttggtca cttccaacta gaagggctgc aacaagctcg
     5581 ccatctgcaa tgtagaagag ggttttaatc gtttgttctt ctggaacatt gaggaaggct
     5641 gcaacttcat caattgattt aacatctggc gttgcaacac gagtaacttc ttcttcagcg
     5701 acaacacggt tgcttggttt gtactcgttt gttgccattt ctaagttagc tgcatagcta
     5761 gactcacttg agtaagcaat ggtatcttca ccagagacta tccatttgag caattctgcc
     5821 ttgatttctt cttgcacttc tgcaggaatt tcgtcaaatg aggcaactga cttgtccaag
     5881 acaacccagc ggtcaaggtc tgtacgagca gatgtaatgg ccataaattc ttggctatcc
     5941 ttaccaccca tggctccacc gtcaccaata atagccttga agtctaaacc actacgagtg
     6001 aaaatacgct cataggctgc tttgtactca tcataaacac tatccaaact atcatagtta
     6061 gcgtggaaac tataagcatc cttcatgata aactcacgtg tacgaagaag tccattacgc
     6121 gggcgttttt catcacgata cttgggctga atttgataaa ggttgagtgg caattgcttg
     6181 taagatttaa cagaatcacg gacaatagct gtaaaggttt cttcgtgagt tggacctaag
     6241 ataaagtctg atttttcacg gttttttagt ttgtaaaggt cttcaccata ggtttcgtaa
     6301 cgacctgatt cacgccacaa ttctgcacta agaagggcag gagccaacat ctcaacagca
     6361 ccaatctttt cgaattcttg gcgcatgatg tttttagctt tttcaatcac acggttggca
     6421 agtggtagat aagaataaac acctgctgaa acttggcgaa cataaccagc acgcaacata
     6481 agagcatggc tgataacttg agcatcgctt ggcatttcgc gaagcgttgg gataggcatt
     6541 ttactttgtt tcataatatt cctcgattat ctaaaaaaga gtcgcataat gtcattccaa
     6601 gtcacagcaa tcatcaagac aaccatgatg accactccgg ccaaggtgac ataggtttca
     6661 atttcttgtt tcaatggttt gcggcggatg gcttctagga tattgagcac aatcttacca
     6721 ccatccaagg ctggaatcgg aataagatta aaaatcccaa tattgatgga aatcattgcc
     6781 aagaagtaca agatattttc aattccattt ttagcagcat cactacttgc cttaaagata
     6841 gcaacaggtc cacccaactt gttcaaatcc ggttggaaaa tcagattttt cagagctgag
     6901 agaattcgga gagctgagtc agcagcagtt gtaaaaccac ctacaaacat ggatagaaaa
     6961 tctgacttaa cccccggttg aacacctaga aggtaacgac cttgactatc ttcgggtgta
     7021 acagtgactt gtttgtcact ccccttttca gaaatagtca catccaaagt cggtgccgtc
     7081 ttatctttgg tttctgtttc cacagcttgg atcaagcttt cccagttgct aacctcatgt
     7141 gagccaatct tggtaatttg tgccgtttct ggtactccta ccttggccaa ggcaccttgg
     7201 ggcatgatat ggaactgatt ggtatcaaca tctctgacac caccctgcat aaagattaaa
     7261 acccaaaaaa caacgacacc taagataaaa ttgttcatag gacctgcaaa attggtaatc
     7321 agtttgcccc agatagtcgc attttgatat tgaacatcta aaggtgcaat ccgaacctca
     7381 gtaccatctg cttccacaac cgttgcatcg tgatccactg caaatgtttt ttcttcttcc
     7441 agaaccaatc ctttgataaa gagcttgtct tcaaaatcaa actgggtcac ctgcataggg
     7501 agggctgttt gatccaattt tttacctgag agattgatgc gtttaacctt accatcatca
     7561 gcaagtgtca aactaacagg cgttcctgtc ttgatttcag ttgtatcatc accccaaccg
     7621 gccatgcgga catagccacc cagaggcaag attcgaatgg tataggccgt tccatccttg
     7681 ccaatgtgag caaaaatttt aggtcccata ccgatggcaa attcacgtac taaaatccct
     7741 gatttcttgg caaagtagaa gtgcccgaac tcgtgcacca ctacaataat cccgaaaacc
     7801 agaataaagg ttaaaattcc gagcatagcg tttcctccgt cttttgatta aaagagtcca
     7861 aataagtgca tgattggaaa tacaagcaac atactatcga aacgatccaa aacaccacca
     7921 tgtccaggga taaatttccc agaatcctta acaccaaaat gacgtttgat cgaactttct
     7981 agtaaatcac caaattgtcc agcaatgcta aagaaaatag caaagactga catcttgtaa
     8041 attccatatg gaagagcaac tgtactgtca actatcataa agataatggt tactaaaatt
     8101 gctcctaaaa taccacccaa ggcaccctca agggttttat taggcgatac ccttggtgct
     8161 aactttcgtt tcccatagtt catcccaaca agataggcac cactgtctgt cgcccagacg
     8221 atacacaagg ctaagagagc cttgtccaaa cctgcaacac gagcatctag taaagcatta
     8281 aatccaaagc ccacgtagaa gctcatagca agagggaaaa ccgcatcctc aatcgtataa
     8341 gacttgctaa aaacggtcgt tcctaacatg attgaaatca aaacactata ggcaaccaca
     8401 ttcccatcaa ctggcaaaaa agtcaggtaa ttctccaagg gaatggtcaa tgcaaaggtt
     8461 gcaaagaggg tcaagaggcc ctccatcgtc atggtctcta gacctctcat cttcaaaagt
     8521 tcatgcatgg ctagcatggc tatgattccg attgctatct gaagcaagag gcccccaatc
     8581 attaaaattg gtaggaaaat agccagggca atccctgcaa acaaggttct tttctgtaaa
     8641 tcctgggtca tatttcctcc taaactcctc caaatcggcg atgacgacga ttataggcaa
     8701 gaatagcttc ctgcaaggcc gcttcgtcaa aatcaggcca taaggtgtcc gtaaaataaa
     8761 gctcactata ggctccctgc catggaagga aattgctcaa acgtaattct ccactagtac
     8821 ggataatcaa gtctgggtct cgtaagtcct taggcaaatg ctgggtaaag agatagttac
     8881 caatcaattc ctctgtgatg tcacctggat tgattttggc atctaaaaca tcctgggaaa
     8941 tcaacttaag cgcctgtgta atctcagcac gtccaccata gttaagagca aaattaagaa
     9001 tcaatcctgt gttgttctta gtcaattcct cagccttggt taaagcttca aaggtttgct
     9061 taggcaggcg gtctgtctcc ccaatcattt gaatcttaac attattcgca tgtagttccg
     9121 ggacataatt atcataaaac tctactggca agttcatgat aaacttgact tcctgatctg
     9181 gacgggtcca gttttccgta gaaaaagcat agaccgtaat aaccttgacg cccagtttgt
     9241 tggctgcctt ggtcacggtt tgcaatgctt ccatgcccgc cttatgtcca aaaactcgcg
     9301 gttgcatacg ttttttagcc caacggccat tgccatccat gatgatgccg atatgagcag
     9361 gaacctgtgt cggaacctct acttccacag ccttatcttt cttaaaaaat ccaaacatga
     9421 tcttattcct attcaaaaat ctatcgtttc attataccat atttccccat tttcttctat
     9481 cactaagcta tttattctca ggcaccatgc ccatttttca aaaaaataag ccgcctgatt
     9541 gggcgacttt atttttatag ggagattatt atgaaaaagt tttaggagtt taagttaagg
     9601 tcttcttaac ttatgaactt agtgtacact ccctagctta aagtttcctt aagtattttt
     9661 aaaaatcaaa tttttccatt tctcctgcca atttttcttg gataaacgtg tttgatagag
     9721 ttccattcgg tcttcatttt ctaagaaatg aggagttgga cgaacttgaa aattcaaaat
     9781 atcctccaaa ccataaggtg cataaagttc aaaatctgat tcttcattca agcgcagtcc
     9841 aactgccgta caccgttctg gatacttact catagcatca cgagaactgg tatagaaagc
     9901 agtgtgagga ctgtgctggt gcatatagac ctgatttttc aattcccact ggtactgagg
     9961 aaaatcctct ctcagctttt tctccagtaa taaggtttcc tcataagaaa aatctggatc
    10021 aaagaaaatc acatctatat ctgtttcatg atcaaaaggg gatttgtctg acaaaagatt
    10081 ccagatgaaa tttctgacag aacctgctgc caactacgag tctttcaaac caaggtctcg
    10141 gatgatcgtc agaatggcca tcatatctgg attttctcta aaagcctcta agatttcttg
    10201 cttatttttc actgtattca taacctaagt gctcatatgc cttagcagtc gccacccgtc
    10261 cagaccgtgt ccgcatgata aaaccttttt gaatcaagta aggctcatac atgtcttcaa
    10321 ctgtctcacg ctcttcggcg atattgacag aaagagttcc tagaccaaca ggtcctccac
    10381 tgtacatctc aatcatggta cgaaggattt tttgatccac atagtccaaa ccttcatggt
    10441 caacatccag catagtcaaa gccttatcgg taataatatc atcgattacc ccattcccca
    10501 ttatctgggc aaaatcgcgc acgcgcttga ggagacgatt ggcaatacga ggggttccac
    10561 gactacgtag ggccaactca gatgctgcct catgagtgat ttccatctca aaaatatctg
    10621 ccgtccgctc gacaatttct gtcaagtcag catgggcata atactccata tgacctgtaa
    10681 tcccaaaacg tgcccgtagt ggatttgaga gcataccagc ccgagtcgtc gcaccaatca
    10741 aggtaaaagg aggcaactcc aaatgaacac tgcgactgcc ttcaccagcc ccaatcataa
    10801 tatctatgta gaagtcctcc atagcactat aaagcacctc ttccactgac attggcaaac
    10861 gatggatctc atcaataaaa aggacatccc caggctctaa ctcattcaaa atagctacca
    10921 gatctccggc tttttcaatg actggacccg acgtctgctt aagattgact cccagttcgt
    10981 tggcaataac aaaggccatg gtcgttttcc cgagacctgg aggcccaaat aagagcacat
    11041 gatccagcgc ttcatcccgc atttttgcag cttcaataaa gatttgtagc tggtccttga
    11101 ccttatcctg tccgatatat tcacgtaaat actgaggacg gagcgtgcgt tctactaact
    11161 cctcatcccc cattatctca ttatctaaaa ttctacccat ggctctatta tatcaaaaaa
    11221 ccaagccaca aacaaaaaag ccacctgatt gggtgactcc taagtttagc acttatgtgg
    11281 tataatatta tacggcactt ctacaccgcc tacgaaagga ggtgagatag cccatgatgg
    11341 aattagtact caaaactatc atcggaccaa ttgtggtcgg tgtcgttctt cgtatagtcg
    11401 ataaatggct aaacaaggac aaatagtgtc aaaaaagacc tcaagcttat ttggtcgtga
    11461 gcttggggtc ttttctagcc tatgatatag aactagtact caattccttt ttattatccc
    11521 atagttcacg aattttgtca aaggtttaca ttttcttcaa ccgctgtacg acaagacggt
    11581 taaaattaag agaacgttag ggattctatc aatttcatag aaattttgat ttcgtaaacg
    11641 aagagacaat cttacatgtc acttttcatt taatacgcca ctactagaca agcaaaatca
    11701 ttattacagt agttccagtc cttcaattaa cagtcactta caatcaaatt gagtttgaac
    11761 tagctgaagc gaccacagac ctatttctta gtcatattcg ctaaaaaaat cccctccaaa
    11821 atctcaaaaa gtccccgcca attccccgac caaaatccga aaaataccga aaaatatcga
    11881 aaaattattt ttagaatagt cccaaaaatc ctgaaataga gctaaaaaac tccacctgat
    11941 tgggtggagt taagggaga
//
LOCUS       DAVLHC010000052        11389 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.053, whole genome shotgun sequence.
ACCESSION   DAVLHC010000052 DAVLHC010000000
VERSION     DAVLHC010000052.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 11389)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11389)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11389
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.053"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            8..418
                     /locus_tag="VXE25_001746"
                     /pseudo
     CDS             8..418
                     /locus_tag="VXE25_001746"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242196.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
     gene            456..758
                     /locus_tag="VXE25_001747"
     CDS             456..758
                     /locus_tag="VXE25_001747"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000590570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEV0772171.1"
                     /translation="MIKILAACGAGVNSSHQIKSALEEELSNRGYDVHCDAVMVKDVN
                     EDLMKGYDIFTPIAATDLGFEPGIPVIEAGPILFRIPAMSVPVFDNIRLPAKQNMV"
     gene            766..1568
                     /locus_tag="VXE25_001748"
                     /pseudo
     CDS             766..1568
                     /locus_tag="VXE25_001748"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="programmed frameshift; internal stop; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS5 family transposase"
     gene            1617..2081
                     /locus_tag="VXE25_001749"
     CDS             1617..2081
                     /locus_tag="VXE25_001749"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldose epimerase"
                     /protein_id="HEV0772172.1"
                     /translation="MGGHPGFNCPLLDDEVYEDYYLEFEKEETCSVPRPFPETGMLDF
                     QDRSPWLEGQKEIDLSYDLFSKDAVTLDELQSRTIALRSLKHDRGLKVHFAEFPNLII
                     WSTLNKGPFITFEPWSGLSTFLEEGDHLEDKKNVCLLEANQVEELGFEIEVL"
     gene            2238..2663
                     /gene="lacA"
                     /locus_tag="VXE25_001750"
     CDS             2238..2663
                     /gene="lacA"
                     /locus_tag="VXE25_001750"
                     /EC_number="5.3.1.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398701.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-6-phosphate isomerase subunit LacA"
                     /protein_id="HEV0772173.1"
                     /translation="MSIVIGADAAGLRLKEVVKDFLEKENFHLVDVTAEGQDFVDVTL
                     AVAAEVNKEEQNLGIVIDAYGAGPFMVATKIKGMVAAEVSDERSAYMTRGHNNSRMIT
                     MGAQLVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKMG"
     gene            2694..3209
                     /gene="lacB"
                     /locus_tag="VXE25_001751"
     CDS             2694..3209
                     /gene="lacB"
                     /locus_tag="VXE25_001751"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-6-phosphate isomerase subunit LacB"
                     /protein_id="HEV0772174.1"
                     /translation="MRIAIGCDHIVTDEKMAVSEFLKSKGYEVIDFGTYDHTRTHYPI
                     FGKKVGEAVTSGQADLGVCICGTGVGINNAVNKVPGVRSALVRDMTTALYAKEQLNAN
                     VIGFGGKITGELLMCDIIEAFIHAEYKPTEENKKLIAKIEHVESHNAQQTDANFFTEF
                     LEKWDRGEYHD"
     gene            3220..4149
                     /locus_tag="VXE25_001752"
     CDS             3220..4149
                     /locus_tag="VXE25_001752"
                     /EC_number="2.7.1.144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000604270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tagatose-6-phosphate kinase"
                     /protein_id="HEV0772175.1"
                     /translation="MILTVTMNPSIDISYPLDELKIDTVNRVVDVTKTAGGKGLNVTR
                     VLSEFGDSVLATGLVGGKLGEFLVEHIDNQVKKDFFSIKGETRNCIAILHGDNQTEVL
                     EKGPEVLEQEGQEFLEHFKKLLESVEVVAISGSLPAGLPVDYYASLVELANQAGKPVV
                     LDCSGAALQAVLESPHKPTVIKPNNEELSQLLGREVSEDLDELKEVLQEPLFAGIEWI
                     IVSLGANGTFAKHGDTFYKVDIPRIQVVNPVGSGDSTVAGISSGLLHKESDAELLIKA
                     NVLGMLNAQEKMTGHVNMANYQVLYDQLIVKEV"
     gene            4151..5131
                     /gene="lacD"
                     /locus_tag="VXE25_001753"
     CDS             4151..5131
                     /gene="lacD"
                     /locus_tag="VXE25_001753"
                     /EC_number="4.1.2.40"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001229146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tagatose-bisphosphate aldolase"
                     /protein_id="HEV0772176.1"
                     /translation="MALTEQKRVRLEKLSDENGIISALAFDQRGALKRLMAQHQTEEP
                     TVAQMEELKVLVADELTKYASSMLLDPEYGLPATKALDEKAGLLLAYEKTGYDTTSTK
                     RLPDCLDVWSAKRIKEEGADAVKFLLYYDVDSSDELNQEKQAYIERIGSECVAEDIPF
                     FLEILAYDEKIADAGSVEYAKVKPHKVIGAMKVFSDPRFNIDVLKVEVPVNIKYVEGF
                     AEGEVVYTREEAAAFFKAQDEATNLPYIYLSAGVSAKLFQDTLVFAHESGANFNGVLC
                     GRATWAGSVEAYIKDGEAAAREWLRTTGFENIDELNKVLQTTATSWKERV"
     gene            5365..6201
                     /locus_tag="VXE25_001754"
     CDS             5365..6201
                     /locus_tag="VXE25_001754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000285719.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HEV0772177.1"
                     /translation="MYRILNPMNHNVSLVRNDKGEEVIVIGKGIAFGKKKGDLITENQ
                     VEKIFRMKTEESRENFMALLKDVPLDFITVTYEIIDKLSKKYHYPIQEYLYVTLTDHI
                     YCSYQALTQGRYKDSNLPDISAKYPVAFQIANEAFEIYRQKLADHFPEDEIIRIAYHF
                     INAEGENEVELVESIDKRKEILRNVEEVLTDYAIQRTKKNNHFYDRFMIHLNYFLDYL
                     DRSRDDNQSLLDMEDHIKQSYPKAFEIGSKIYDVITQHTGLDLYKSERVYLVLHIQRL
                     LS"
     gene            6237..6554
                     /locus_tag="VXE25_001755"
     CDS             6237..6554
                     /locus_tag="VXE25_001755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HEV0772178.1"
                     /translation="MNREEVTLLGFEIVAYAGDARSKLLEALKAAEAGDFEKADALVE
                     EAGSCIAEAHHAQTSLLTKEASGEDLAYSVTMMHGQDHLMTTILLKDLMHHLIELYKR
                     GVK"
     gene            6556..8250
                     /locus_tag="VXE25_001756"
     CDS             6556..8250
                     /locus_tag="VXE25_001756"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001037357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HEV0772179.1"
                     /translation="MDKLIIFIEKGKPFFEKLSRNIYLRAIKDGFISSMPAVLFSSIF
                     ILIAAVPNIFGFKWSDEQLAFILKPYNYSMGILALLVAGTTAKSLTDSVNTRSMEKTN
                     QINYMSTFLAAVVGLLILAADPIEGGFANGLLGTRGLLTAFLAAFITVNIYKVCIKNN
                     VTIRLPEEVPPNIAQVFKDVIPFALSVLSIYGLDLIVRNIFGTNVAESVGKILAPLFS
                     ATDGYIGLAIVFGAYAFFWFVGIHGPSVVEPLIVAISYANIEANVQLVQAGMHADKIL
                     NPVTQTFVVTMGGTGATLVVPFMFMWLCKSKRNRIVGRASVVPTFFGVNEPILFGAPI
                     VLNPIFFIPFVTAPIINVWIMKFFVDVLQMNSFSIILPWTTPAPIGIVMGTALAPLSF
                     VLAITLIIIDTLIYYPFVKVYDHQILEEERKGNSSSELKEKVAANFNTAKADAILEKA
                     GVDAAQNTITEETNVLVLCAGGGTSGLLANALNKAAAEYNVPVKAAAGGYGAHREMLP
                     EFNLVILAPQVASNFEDMKAETDKLGIKLAKTEGAQYIKLTRDGKGALAFVQEQFD"
     gene            8465..9871
                     /gene="lacG"
                     /locus_tag="VXE25_001757"
     CDS             8465..9871
                     /gene="lacG"
                     /locus_tag="VXE25_001757"
                     /EC_number="3.2.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864138.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-galactosidase"
                     /protein_id="HEV0772180.1"
                     /translation="MTKTLPKDFIFGGATAAYQAEGATHTDGKGPVAWDKYLEDNYWY
                     TAEPASDFYNRYPVDLKLAEEYGVNGIRISIAWSRIFPTGYGQVNAKGVEFYHNLFAE
                     CHKRHVEPFVTLHHFDTPEALHSNGDFLNRENIEHFVDYAAFCFEEFPEVNYWTTFNE
                     IGPIGDGQYLVGKFPPGIQYDLAKVFQSHHNMMVSHARAVKLYKEKGYKGEIGVVHAL
                     PTKYPLDHENPADVRAAELEDIIHNKFILDATYLGHYSEKTLAGVEAILAANGGSLDL
                     REEDFTALEAAKDLNDFLGINYYMSDWMEAFDGETEIIHNGKGEKGSSKYQIKGVGRR
                     VAPDYVPRTDWDWIIYPQGLYDQIMRVKKDYPNYKKIYITENGLGYKDEFVDNTVYDD
                     GRIDYVKQHLEILSDVIADGANVKGYFIWSLMDVFSWSNGYEKRYGLFYVDFETQERY
                     PKKSAHWYKKVAETQIID"
     gene            9914..10171
                     /locus_tag="VXE25_001758"
     CDS             9914..10171
                     /locus_tag="VXE25_001758"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000471575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3884 family protein"
                     /protein_id="HEV0772181.1"
                     /translation="MFKDFIQSIYEKVYIINFEKCSQIPCLTSEELKSLGKWYVSTGK
                     EWICHSDDELEEFKNLFLNFINPEEWDTISFDSDFMPFQQS"
     gene            complement(10449..11210)
                     /locus_tag="VXE25_001759"
     CDS             complement(10449..11210)
                     /locus_tag="VXE25_001759"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000917571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HEV0772182.1"
                     /translation="MLKQEKLAKILEIVNSKGTITVKQIMDEIAVSDMTARRYLQELA
                     DKDLLIRVHGGAEKLRTNSLLTNERSNIEKQALQTAEKQEIAHFAGSLVEERETIFIG
                     PGTTLEFFARELPIDNIRVVTNSLPVFLILSERKLTDLILIGGNYRDITGAFVGTLTL
                     QNLSNLQFSKAFVSCNGIQNGALATFSEEEGEAQRIALNNSNKKYLLADHSKFNKFDF
                     YTFYNVSNLDTIVSDSKLSDSILFKLSKHIKVIKP"
BASE COUNT         3658 a         1954 c         2301 g         3476 t
ORIGIN      
        1 agaataactc tttgatcagg tagcaagctt gttggaggaa cgagaaattg taactccaac
       61 ttatcgtgaa gccttgatca cgcgtgaaaa gtcatttcca actggtttag atatggaatt
      121 tctaggaaag gacttgccaa atgtagcgat tcctcacaca gatattgttc ataatttggc
      181 tgaaaaagtt gtggtcgttc gattagagaa accggtgact ttccataata tgattgcgcc
      241 agataaggaa gtagaagtat ccttgctctt ctttatcatt aataattcaa gttcaagtca
      301 aacgaacatt cttgctcagt taatggactt cttcacagga aatggtcatc ttgaagacct
      361 atcaaaaatt tctgaaccag aagcccttta tgcttacatt gctgaagcaa ccgcttaatc
      421 ttgtctatta aaaaataaaa tcggaggaaa tccaaatgat taaaattctt gctgcctgcg
      481 gtgcaggtgt taactcaagt caccaaatta aaagtgctct agaagaagaa ctttcaaacc
      541 gtggttacga tgttcactgt gatgcagtta tggtgaaaga tgtaaacgaa gaccttatga
      601 aaggttacga tatctttaca ccaatcgctg caacagacct tggttttgaa ccaggtatcc
      661 cagttatcga agctgggcca atcttattcc gtatcccagc aatgagcgtt ccagtatttg
      721 acaatattag acttcctgcg aaacaaaaca tggtatagta gttctatgaa tgatgaagca
      781 agtaaacaac taactgatgc acgatttaag cgtcttgttg gtgttcagcg cacgactttt
      841 gaagagatgt tagctgtatt aaaaacagct tatcaactta aacacgcaaa aggtggacga
      901 aaacctaaat taagcctaga agaccttctt atggccactc ttcaatatgt gcgagaatat
      961 cgaacttatg aagaaattgc ggctgatttt ggtatccacg aaagcaactt actccgtcgg
     1021 agctaatggg ttgaagtaac tcttgttcaa agtggtttta cgatttcaag aactcctctc
     1081 agttctgagg acacggtaat gattgatgcg acggaagtac aaatcaatcg ccctaaaaaa
     1141 gaattagcga atgattctgg taaaaagaaa tgccacgcta tgaaggctca agcgattgtc
     1201 acaagtcaag ggagattgtt tctttggata tcactgtgaa ctattgtcat gatatgaagt
     1261 tgttcaaaat gagtcgcaga aatatcggac aagctggtaa aatcttggct gacagtggtt
     1321 atcaagggct catgaagata tatcctcaag tacaaactcc acgtaaatcc agcaaactca
     1381 agccgctaac agttgaagat aaaacctata accatgcgct atctaaggag agaagcaagg
     1441 ttgagaacat ctttgccaaa gtaaaaacgt ttaaaatgat ttcaacaacc tatcgaaatc
     1501 atcgtaaacg cttcggatta cgaatgaatt tgattgctgg cattatcaat catgaactag
     1561 gattctagtt ttgcaggaag tctaataaag aaactagcaa ggtcaggcct tactttattg
     1621 gtggacatcc aggatttaat tgtcctctac ttgatgatga agtctatgaa gattattatc
     1681 tagagtttga aaaagaagag acttgctctg ttccacgtcc tttcccagaa acaggtatgt
     1741 tggatttcca agatagaagt ccatggctag agggacaaaa agaaatagat cttagttatg
     1801 atcttttcag caaagatgca gtgactttgg atgaattgca atctcgaaca attgcccttc
     1861 gttctcttaa acatgatagg ggattgaaag tgcattttgc agaatttcca aacctcatca
     1921 tctggtcaac tttgaacaag ggacctttca ttacctttga accatggtct ggcttgtcaa
     1981 cattccttga agaaggagat catttagaag ataagaagaa tgtttgtctc ttagaagcca
     2041 atcaggttga agaattaggg tttgagatag aagttttata aaaaagtaaa aaataaataa
     2101 caaaaacaaa cacaaactgt tgacttcttc aaacaatagt agtatattat gtttgtgagg
     2161 actaattgac tgttttttaa agacagccaa tacactgctg gaatccagca tagaaaaaat
     2221 aaaaaggagt atacaatatg tctattgtta tcggtgcaga tgctgcaggt ttgagattga
     2281 aagaagttgt gaaagacttc ttagaaaaag aaaacttcca ccttgtggat gttacagctg
     2341 aaggtcaaga ctttgttgat gtgactctcg ctgttgctgc agaagtaaac aaagaagaac
     2401 aaaaccttgg tatcgtgatt gatgcttatg gagctggtcc atttatggtt gcaactaaga
     2461 tcaaaggaat ggttgctgca gaagtttctg atgaacgttc agcttatatg actcgtggcc
     2521 acaacaactc acgtatgatc actatgggtg cacaacttgt tggtgatgaa ttggctaaaa
     2581 acatcgctaa aggatttgtt aatggtaaat acgacggtgg tcgtcaccaa atccgggttg
     2641 acatgttgaa caaaatgggc taattagatt atagtaagaa aggtaagtta aaaatgagaa
     2701 ttgcaattgg atgtgaccac atcgtaacag atgaaaaaat ggcggtttca gaatttttga
     2761 aatcaaaagg atatgaagtc attgactttg gtacatatga ccatacacgg actcactacc
     2821 caatctttgg taaaaaagta ggggaagctg taactagcgg tcaagctgat cttggagtat
     2881 gtatctgtgg tactggtgtt ggtatcaaca acgctgtaaa taaagttcca ggtgttcgtt
     2941 ctgccttggt tcgtgatatg acaacagccc tttatgctaa agaacaattg aacgctaacg
     3001 ttattggttt tggtggtaaa attactggtg aattgcttat gtgtgatatc atcgaagctt
     3061 tcatccatgc tgaatacaaa ccaactgaag aaaacaaaaa attgattgcg aaaattgaac
     3121 atgttgaaag tcacaatgct caacaaacag acgcaaactt ctttacagaa ttccttgaga
     3181 aatgggatcg tggagaatac cacgactaag aggtgaccta tgattttaac agtcacaatg
     3241 aacccatcca tcgatatttc ctatcccttg gatgagttga agattgatac tgtcaatcgt
     3301 gtggtggatg taaccaaaac ggctggtggt aagggactca atgttacccg agtactttca
     3361 gaatttggcg attctgttct tgctactggt ttagtgggtg gcaaacttgg tgagtttttg
     3421 gttgaacata tcgataatca agtaaagaaa gatttcttct caattaaggg agaaactcgt
     3481 aactgtatcg ctattctcca cggagacaac caaacagaag ttcttgaaaa aggtcctgaa
     3541 gtattggaac aggaaggtca agagtttttg gaacatttca aaaaactctt ggagtcagtt
     3601 gaagtagtgg ccatctcagg tagtctgcca gctggccttc cagttgatta ctatgcgagc
     3661 ttggtagaac ttgctaatca agctggcaag cctgtagtct tggactgctc aggtgcagca
     3721 cttcaggctg ttcttgaatc accccataaa ccaacagtca tcaaaccaaa taatgaagaa
     3781 ttgtctcagc ttcttggaag agaagtttct gaggatttgg atgaattaaa agaagtactt
     3841 caagaacctt tgtttgcagg gattgaatgg attatcgttt cacttggtgc caacggtact
     3901 tttgccaaac atggtgacac tttctacaag gtagatattc ctagaattca ggtggtaaat
     3961 cctgttggat ctggagactc tactgtggca ggaatttctt caggacttct tcacaaagaa
     4021 tcggatgcag aattactcat caaggcaaat gtccttggta tgctcaatgc tcaagaaaaa
     4081 atgactggtc atgtcaacat ggccaactat caagttctat atgatcaatt aatagtaaaa
     4141 gaggtataaa atggctttaa cagaacaaaa acgtgtacgc ttagaaaaac tttctgatga
     4201 aaatggtatc atctcagctc ttgcatttga ccaacgtggt gctttgaaac gcctcatggc
     4261 tcaacaccaa acagaagaac caactgtggc ccaaatggaa gaacttaaag tcttggtagc
     4321 agatgaattg actaaatacg cttcatctat gcttcttgac cctgagtatg gacttccagc
     4381 aactaaagct cttgatgaaa aagctggcct tctccttgct tatgaaaaaa caggttatga
     4441 cacaacaagc acaaaacgct tgccagactg cttggatgtc tggtctgcaa aacgtattaa
     4501 agaagaaggt gcagatgcag ttaaattctt gctttactat gatgtagata gctcagacga
     4561 actcaatcaa gaaaaacaag cctacatcga acgcatcggt tctgagtgtg tggctgaaga
     4621 tatcccattc ttccttgaaa ttcttgctta cgatgaaaaa attgcggatg caggttctgt
     4681 agaatacgcg aaagtaaaac cacacaaagt tatcggcgct atgaaagtct tttcagaccc
     4741 acgctttaac attgatgtct tgaaagttga agttcctgtt aacattaaat atgttgaagg
     4801 cttcgctgaa ggtgaagtag tttatacacg tgaagaagca gcagccttct tcaaagcgca
     4861 agatgaagca acgaacttgc catacatcta cttgagtgct ggtgtatcag ctaaactctt
     4921 ccaagatact cttgtatttg ctcatgaatc aggtgcaaac tttaacggag ttctttgtgg
     4981 ccgtgctaca tgggcaggat cagttgaagc ttacatcaaa gatggtgaag cagcagctcg
     5041 cgaatggctt cgcacaactg gatttgaaaa cattgatgag ctcaataaag ttcttcaaac
     5101 aacagcgact tcatggaaag aacgtgtgta agaaagtcct cctagtttag gaacatgaat
     5161 ctaaaaaaat ttaaaaaaag ttgtatgtaa aggtttacaa aataacttac ttgtgctata
     5221 cttaaatcac aagttaatac aaggtgagtg ttactaagta atattaggca tgatcacagg
     5281 tgaattagaa atcagctgat tttctagttc atttgtggtc attttttgta ctcatatacc
     5341 tttaagatat aaaaggaggt tgacatgtat cgaattctaa atccaatgaa tcacaatgtc
     5401 tcgcttgtca gaaatgataa gggagaagag gtgattgtaa ttggtaaggg gattgcattc
     5461 ggaaagaaga agggggattt gattactgaa aatcaggttg agaaaatctt tcggatgaag
     5521 accgaagagt ccagagaaaa ctttatggct cttctcaaag atgttccgct tgattttatc
     5581 acagtgacct atgaaatcat tgataagcta tcaaagaaat atcattatcc gattcaagag
     5641 tatctctatg taaccttgac agatcatatt tactgttctt atcaagctct aactcaagga
     5701 aggtacaagg atagtaatct gccagatatt tccgctaagt atcctgtcgc ttttcaaatc
     5761 gcaaatgaag cttttgaaat ttaccgtcag aagctagcag atcattttcc tgaggacgaa
     5821 attattcgga ttgcttatca tttcattaat gctgaaggtg aaaatgaagt ggaacttgtg
     5881 gagtcgattg ataagaggaa agaaattctc aggaatgttg aagaagtttt aacggactat
     5941 gcaattcaac gaactaaaaa gaataaccat ttctatgatc gctttatgat ccatttgaat
     6001 tatttcttgg attatttaga cagatctaga gatgataacc aatcacttct ggatatggaa
     6061 gatcatatta aacaatccta tccaaaagcc ttcgagattg gttccaagat ctatgatgtg
     6121 attacgcaac atacgggtct tgatttgtat aaaagtgaac gagtttatct agttctacat
     6181 atccaacgtt tattgtcata aaaatttatt taaaactata taaggagaat tctatcatga
     6241 atagagaaga agtaacattg ttaggttttg aaatcgtagc ctatgctggc gatgctcgtt
     6301 caaaactatt ggaagccttg aaggctgctg aagctggtga ttttgaaaaa gcggacgctc
     6361 tggtagagga agctggtagc tgtattgcag aggctcacca cgcgcaaaca agtctattga
     6421 ctaaggaagc ttctggtgag gacttagcgt atagtgtgac catgatgcat ggtcaagatc
     6481 acttgatgac aactatcttg ttaaaagacc taatgcacca tttaattgaa ctttacaaga
     6541 gaggagttaa ataaaatgga taagttaata atttttattg agaaaggaaa gcctttcttt
     6601 gaaaaattat cgagaaatat atacttaaga gcgataaaag atggttttat ttccagtatg
     6661 ccagcagtat tattctcaag tatttttata ctaatagctg ctgtgcccaa tatttttggg
     6721 tttaaatggt ctgatgaaca gttagctttt attttgaaac cttacaacta ctcaatggga
     6781 attttagctc tcttagtagc tgggacaact gcaaaatcgt taacagattc agttaataca
     6841 cgtagtatgg agaaaaccaa ccaaatcaac tacatgtcaa cttttttagc agctgttgtt
     6901 ggattgttaa tactggcagc tgatccaatt gaaggtggat ttgctaatgg tcttttaggt
     6961 actagaggat tacttactgc atttttggca gcttttatta cagtaaatat ctataaagta
     7021 tgtattaaaa ataatgtaac cattagactt cctgaagagg ttccaccaaa tattgcacaa
     7081 gtttttaaag atgttattcc gtttgcctta tctgttcttt caatatatgg attggattta
     7141 attgttagaa atatttttgg tacaaatgta gcagaatctg ttggtaaaat attagcccct
     7201 ctattttcag ctactgatgg ttatatcggt ttagctattg tatttggtgc ttatgctttc
     7261 ttttggtttg ttggaattca tgggccatct gttgtagaac ctttaattgt agctatcagt
     7321 tatgcaaata tagaagctaa tgttcagctt gtgcaagctg gtatgcacgc agataaaatt
     7381 ttaaatccag ttactcaaac ttttgttgta acaatgggtg gtactggtgc aacactagta
     7441 gttccattta tgtttatgtg gttatgtaaa tcaaaaagaa atagaattgt cggacgtgcg
     7501 tctgtagttc ctactttctt tggcgtaaat gaaccaatcc tatttggtgc tccaattgtt
     7561 ttaaatccta tcttctttat tccgtttgtt actgctccta ttatcaatgt ttggattatg
     7621 aaattttttg tagatgttct acaaatgaat agtttcagta ttattttacc ttggacaaca
     7681 cctgctccaa ttggtattgt tatgggaacg gcgctggctc cattgtcatt cgtcttggct
     7741 ataactttaa tcattatcga cactttaatc tattatccat ttgttaaagt ttatgaccat
     7801 caaattttag aagaagaacg gaaaggaaac tcttcatctg aattgaaaga aaaagttgct
     7861 gcaaacttca acactgcaaa agcggatgct attcttgaaa aagcgggtgt cgatgcagca
     7921 caaaatacca tcactgaaga aacaaatgtc ctcgttctct gtgctggtgg aggtacaagt
     7981 ggactccttg caaatgcttt gaataaggca gcagcagaat acaatgtccc tgtgaaagca
     8041 gcagcaggcg gctatggtgc tcaccgtgaa atgttaccag agtttaatct agttatcctt
     8101 gcccctcaag ttgcttcaaa ctttgaagat atgaaggcag aaacagataa gctcggtatt
     8161 aaacttgcta agacagaagg cgctcaatac atcaaattaa ctcgtgatgg aaaaggtgcc
     8221 ctagcattcg tacaagagca attcgattaa ggctaggaac tgtgaaacag tctcccatcg
     8281 ttacggaaat cgctatggcg aatttcctaa tcgccttatt aattcgtcgg taaaaagata
     8341 tcgtttttac ctcctcatgt cacaattcag tgacttggta caagaagtga gatggagaag
     8401 catggctcac tgactcctct cctctcactt ttactttatt taaatcaaga aataggtgaa
     8461 aaaaatgaca aaaacacttc caaaagactt tattttcggt ggcgcaacag ctgcttatca
     8521 agcagaaggt gctacacata ctgatggaaa aggaccagtt gcttgggata aatatcttga
     8581 ggataactac tggtacactg ccgaaccagc tagtgatttt tacaatcgat atccagttga
     8641 cctcaagcta gcagaagagt atggtgtcaa tggtattcga atttctattg cttggtcacg
     8701 tattttcccg actggttacg gccaagtaaa tgctaaaggt gttgagtttt atcataattt
     8761 atttgcagag tgtcacaaac gtcatgttga gccttttgta actcttcatc actttgacac
     8821 gccagaagct ctccactcaa atggagactt cttaaaccgt gaaaatatcg aacattttgt
     8881 agactacgct gctttctgtt ttgaagaatt tccagaagta aactattgga caacctttaa
     8941 tgaaattgga ccaatcggtg atggtcaata tttggttggg aaattccctc caggtatcca
     9001 gtacgacctt gccaaagtct ttcaatcaca ccacaatatg atggtgtctc atgcacgcgc
     9061 ggtaaaattg tacaaagaga aaggctataa aggggaaatt ggtgttgttc acgccctgcc
     9121 tactaaatat cctctagatc atgaaaatcc agcagatgtt cgtgcagctg agttggaaga
     9181 tattattcac aacaaattta ttttggatgc aacctatctg ggtcactact ctgaaaagac
     9241 tctggcaggg gtagaggcta tcttggctgc caatggtggt agcttggatc ttcgtgaaga
     9301 agattttaca gcattagaag ctgcaaaaga cttgaatgat ttcctaggaa tcaactacta
     9361 tatgagtgac tggatggaag cctttgatgg agaaactgaa attatccata atggtaaagg
     9421 tgaaaaagga agctctaagt atcaaatcaa aggtgttggt cgtcgtgtag ctcctgacta
     9481 tgtaccacgc acggattggg attggattat ctaccctcaa ggtttgtatg accaaatcat
     9541 gcgcgtgaag aaagattatc ctaactacaa gaagatttac atcactgaaa atggtctcgg
     9601 ctataaagat gagttcgttg ataacactgt ttacgatgat ggtcgtattg attacgtgaa
     9661 acaacacttg gagatcttgt ctgatgtgat tgcagatgga gctaatgtaa aaggttactt
     9721 catttggtca ttaatggatg tcttctcatg gtcaaacggt tatgagaaac gttatggtct
     9781 cttctacgta gattttgaaa ctcaagaacg ttatcctaag aaatcagctc actggtacaa
     9841 gaaagtagcg gaaactcaga ttatagacta gtagaattag tcattagata tagaatttta
     9901 gtgagtcaaa aagatgttca aagattttat ccaatctatt tatgaaaaag tttatattat
     9961 aaatttcgaa aaatgctctc aaataccgtg tttgacgagt gaagaattga aaagtcttgg
    10021 aaaatggtat gtctcgactg gtaaagaatg gatttgtcat tcagatgatg agctggaaga
    10081 atttaaaaat ctatttttaa attttatcaa tcctgaagaa tgggatacta tctcctttga
    10141 ttcagatttt atgccgtttc aacaatcgta accaatttct caaaaaagtt aaatcttata
    10201 tttagtactc tgtaaaactc ttatctaatc acgttgctta tactcaatga aaatcaaaga
    10261 gcaactttaa actaggaagc gagtcgcaga tttctcaatg catagctttg aggaattggg
    10321 caaaaagtct ttgatataga aaaacgcata gtatcaggtg tttcaacacc tgatactatg
    10381 cgttttattg tgggaagatt tacttttttc ttctgaaatt gagttgttac ccaggctctt
    10441 tcagtttatt aaggcttgat gactttaatg tgtttagata gcttaaaaag gattgaatca
    10501 cttagtttag aatctgaaac aatagtatca agatttgata cattataaaa agtataaaaa
    10561 tcaaacttat tgaacttgct atgatctgcg agtaaatatt ttttattaga attatttaaa
    10621 gcgatgcgtt gagcctctcc ctcttcctcg ctaaaagtag ctagagctcc gttttgaata
    10681 ccattacagc taacgaaagc tttagaaaat tggagattag agagattttg tagggtcaat
    10741 gtaccaacaa aagcacctgt aatatcgcga taatttccac ctattaaaat caaatctgtt
    10801 aattttcgtt cgcttaaaat cagaaaaaca ggtagactgt tggttacgac gcggatattg
    10861 tcaataggca actcacgcgc aaaaaactct aatgttgttc ctggtccaat gaaaatagtt
    10921 tctctttctt ctactagact gcctgcaaaa tgggctattt cttgtttttc tgccgtttgg
    10981 agggcttgtt tttcaatatt tgatcgctca ttagtcaaaa gggagttggt tcgaagtttt
    11041 tcagctccac catgcacacg aatcagcaaa tctttatcag ctaattcctg taaatagcgc
    11101 cttgcagtca tatctgaaac ggctatttcg tccataatct gtttaactgt tatggttcct
    11161 ttactattta ctatctctaa aattttggct aatttttctt gtttgagcat attatcacct
    11221 cgtttcctac tactatctta ccataaacaa actcatcatt caaatacaaa aacaacaaaa
    11281 taaaacaaaa acaaaaatat cgaggtttat tttcaaaact ttcgatattt ttattaagtt
    11341 attattttgt tgtttctagt ttactttttg atggttaaga gtggtggag
//
LOCUS       DAVLHC010000053        11294 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.054, whole genome shotgun sequence.
ACCESSION   DAVLHC010000053 DAVLHC010000000
VERSION     DAVLHC010000053.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 11294)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11294)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11294
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.054"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            117..433
                     /locus_tag="VXE25_001760"
                     /pseudo
     CDS             117..433
                     /locus_tag="VXE25_001760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000040325.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron reverse transcriptase/maturase"
     gene            complement(518..1000)
                     /locus_tag="VXE25_001761"
     CDS             complement(518..1000)
                     /locus_tag="VXE25_001761"
                     /EC_number="4.4.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002893508.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-ribosylhomocysteine lyase"
                     /protein_id="HEV0772183.1"
                     /translation="MSKEVIVESFELDHTIVKAPYVRLIGEETGPKGDIISNYDIRLV
                     QPNEYSIPTAGLHTIEHLLAKLIRTRIDGMIDCSPFGCRTGFHMIMWGRHTSAKIAAV
                     IKDSLKEIAETTTWEDVPGTTIESCGNYKDHSLFSAKEWAKLILEQGISDDAFERHVI
                     "
     gene            complement(1095..2579)
                     /locus_tag="VXE25_001762"
     CDS             complement(1095..2579)
                     /locus_tag="VXE25_001762"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008535024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1846 domain-containing protein"
                     /protein_id="HEV0772184.1"
                     /translation="MKKQAFSSEQYLNLQRDHILERINQFDGKLYLEFGGKMLEDFHA
                     ARVLPGYEPDNKIKLLQELKEQVEVVIAINASNIEHSKARGDLGISYDQEVLRLIDKF
                     NELGIFVGSVVITQYAGQLAADAFRNQLEKNGIDSYLHYPIKGYPTDMDHIISPEGMG
                     KNDYIKTSRNLIVVTAPGPGSGKLATCMSNMYHDQINGIKSGYAKFETFPVWNLPLHH
                     PVNLAYEAATADLDDVNMIDPFHLQTYGETTVNYNRDIEIFPVLKRMLERILGKSPYA
                     SPTDMGVNMVGFAITDDEAAVEASKQEIIRRYYQTVLDFKAEKVGEAAVKKIELLMND
                     LGISPADRKVAVVARQKAEETGGPALAFELPNGEIVTGKNSELFGPTAAALINAIKKS
                     ADIAKEVKLIEPEVVKPIQGLKIDHLGSRNPRLHSNEILIALAITATENPDAARAMEE
                     LGNLKGSEAHSTIILTDEDKNVLRKLGINVTFDPYYQYDRLYRK"
     gene            2732..4339
                     /locus_tag="VXE25_001763"
     CDS             2732..4339
                     /locus_tag="VXE25_001763"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-glucosidase"
                     /protein_id="HEV0772185.1"
                     /translation="MQEKWWHNAVVYQVYPKSFMDSNGDGVGDLPGITSKLDYLAKLG
                     ITAIWLSPVYDSPMDDNGYDIADYQAIATIFGTMEDMDQLIAEAKKRDIRIIMDLVVN
                     HTSDEHAWFVEACENTDSPERDYYIWRDEPNDLDSIFSGSAWEYDEKSGQYYLHFFSK
                     KQPDLNWENEKLRQKIYEMMNFWIDKGIGGFRMDVIDMIGKIPDEKVVNNGPMLHPYL
                     KEMNQATFGDKNLLTVGETWGATPEIAKLYSDPKGQELSMVFQFEHIGLQYQEGQPKW
                     HYQKELNIAKLKEIFNKWQTELGVEDGWNSLFWNNHDLPRIVSIWGNDQEYREKSAKA
                     FAILLHLMRGTPYIYQGEEIGMTNYPFETLDQVEDIESLNYAREALEKGVPIEEIMDS
                     IRVIGRDNARTPMQWDESKNAGFSTGQPWLAVNPNYEMINVQEALANPDSIFYTYQKL
                     VQIRKENSWLIRADFELLDTADKVFAYIRKDGDRRFLVVANLSNEEQDLTVEGKVKSV
                     LIENTLAQEVFEKQILVPWDAFCVELL"
     gene            4498..4650
                     /locus_tag="VXE25_001764"
     CDS             4498..4650
                     /locus_tag="VXE25_001764"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001022221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-ribosylhomocysteinase"
                     /protein_id="HEV0772186.1"
                     /translation="MNIKKRVLSAGLTFASALLLAACDQSGSDTKTYSSTFSGNPTTF
                     NYLLDY"
     gene            complement(4664..5186)
                     /locus_tag="VXE25_001765"
                     /pseudo
     CDS             complement(4664..5186)
                     /locus_tag="VXE25_001765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558102.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            5409..6854
                     /gene="cps4A"
                     /locus_tag="VXE25_001766"
     CDS             5409..6854
                     /gene="cps4A"
                     /locus_tag="VXE25_001766"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000091082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Cps4A"
                     /protein_id="HEV0772187.1"
                     /translation="MSRRFKKSSSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNILAF
                     RYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLVFSILVSSVSLFAVQQFVGLTNR
                     LNATSNYSEYSISVAVLADSDIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNTDLT
                     VDQSSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKVEAP
                     KTSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPIADG
                     GNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQ
                     EFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTST
                     EALKNYSTIINSLQDSIQTNMPLETMINLVNAQLESGGNYKVNSQDLKGTGRTDLPSY
                     AMPDSNLYVLEIDDSSLAVVKAAIQDVMEGR"
     gene            6856..7587
                     /locus_tag="VXE25_001767"
     CDS             6856..7587
                     /locus_tag="VXE25_001767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine protein phosphatase"
                     /protein_id="HEV0772188.1"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLAESYRQGVRIIVSTSHRR
                     KGMFETPEEKIAENFLQVREIAKEVASDLVIAYGAEIYYTPDVLDKLEKKRIPTLNDS
                     RYALIEFSMNTPYRDIHSALSKILMLGITPVIAHIERYDALENNEKRVRELIDMGCYT
                     QVNSSHVLKPKLFGERYKFMKKRAQYFLERDLVHVVASDMHNLDSRPPYMQQAYDIIA
                     KKYGAKKAKEFFVDNPRKIIMDQLI"
     gene            7596..8288
                     /gene="cpsC"
                     /locus_tag="VXE25_001768"
     CDS             7596..8288
                     /gene="cpsC"
                     /locus_tag="VXE25_001768"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000664160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     CpsC"
                     /protein_id="HEV0772189.1"
                     /translation="MKEHNTLEIDILQLFRALWKRKLVILLVAIITSSVAFAYSTFVI
                     KPEFTSTTRIYVVNRNQEEKSGLTNQDLQAGTYLVKDYREIILSQDVLEEVISDLKLD
                     LTPKGLANKIKVTVPVDTRIVSVSVNDRVPEEASRIANSLREVAAQKIISITRVSDVT
                     TLEEARPAISPSSPNIKRNILIGFLAGGVGTGVIVLLLELLDTHVKRPEDIEDTLQMT
                     LLGVVPNLSKLK"
     gene            8298..8981
                     /gene="cpsD"
                     /locus_tag="VXE25_001769"
     CDS             8298..8981
                     /gene="cpsD"
                     /locus_tag="VXE25_001769"
                     /EC_number="2.7.10.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001142521.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis tyrosine autokinase
                     CpsD"
                     /protein_id="HEV0772190.1"
                     /translation="MPTLEIAQKKLEFIKKAEEYYNALCTNIQLSGDKLKVISVTSVN
                     PGEGKTTTSVNIARSFARAGYKTLLIDGDTRNSVMSGFFKSREKITGLTEFLSGTADL
                     SHGLCDTNIENLFVVQSGSVSPNPTALLQSKNFNDMIETLRKYFDYIIVDTAPIGIVI
                     DAAIITQKCDASILVTATGEVNKRDVQKAKQQLEQTGKLFLGVILNKFDVQHKKYGSY
                     GDYGNYGKK"
     gene            8997..10364
                     /locus_tag="VXE25_001770"
     CDS             8997..10364
                     /locus_tag="VXE25_001770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001013545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar transferase"
                     /protein_id="HEV0772191.1"
                     /translation="MDEKGLKIFLAVLQSIIVILLVYFLSFVRETELERSSMVILYLL
                     HFFVFYFSSYGNNFFKRGHLVEFNSTIRYIFFFAIAISVLNFFIAERFSISRRGMVYF
                     LTLEGISLYLLNFLVKKYWKHVFFNLKNSKKILLLTVTKNMEKVLDKLLESDELSWKL
                     VAVSVLDKSDFQHDKIPVIEKEKIIEFATHEVVDEVFVNLPGESYDIGEIISRFETMG
                     IDVTVNLKAFDKNLGRNKQIHEMVGLNVVTFSTNFYKTSHVISKRILDICGATIGLVL
                     FAIASLVLVPLIRKDGGPAIFAQTRIGKNGRHFTFYKFRSMRIDAEAIKEQLMDQNTM
                     QGGMFKMDNDPRVTKIGRFIRKTSLDELPQFWNVFIGDMSLVGTRPPTVDEYDQYTPE
                     QKRRLSFKPGITGLWQVSGRSKITDFDDVVKLDVAYIDNWTIWKDIEILLKTVKVVFI
                     RDGAK"
     gene            10368..10817
                     /locus_tag="VXE25_001771"
     CDS             10368..10817
                     /locus_tag="VXE25_001771"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017650132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine--LPS N-acetylglucosamine
                     transferase"
                     /protein_id="HEV0772192.1"
                     /translation="MKVCLVGSSGGHLTHLYLLKPFWNDKERFWVTFDKADARSVLSE
                     EVVYPCYYPTNRNIKNLIKNTFLAYKILKKERPDLIISSGAAIAVPFFYIGKLFGSKT
                     VYIEVFDRIDASTLTGKLVYPVTDRFIVQWEEMKKVYPKAINLGGIF"
     gene            10817..>11294
                     /locus_tag="VXE25_001772"
     CDS             10817..>11294
                     /locus_tag="VXE25_001772"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000578434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug MFS transporter"
                     /protein_id="HEV0772193.1"
                     /translation="MIFVTVGTHEQQFDRLIKEVDYLKKENLIQDEVFIQIGYSSYIP
                     KYCEWEKIISYEKMNQLIKESDIIITHGGPATFMGVIAKGKVPIVVPRQKKFGEHVND
                     HQLQFVKLTKEIYNFIVIDDISDLYLSIRDFKDKYFGICLNNERFNLHFNAEINKLF"
BASE COUNT         3528 a         1881 c         2424 g         3461 t
ORIGIN      
        1 agcgaaatcg tggctttacg aacaggaacg tgatagtaag gcgtatatag cggataaggg
       61 ggtctcaaac tctaaagttc aaaaaggtag tcgtaaccta tatgcgtaaa tcacgagagc
      121 aactgaattt gttcattcga ggatggataa actatttctc attgggaaat atgaaaagta
      181 tagtcgccag catagatgag cgcttgcgta ctcgcctacg agtgattatc tggaagcaat
      241 ggaagaagaa atcgagacga ttatggggat tgcttaagtt aggagttcct aaatggatag
      301 cagataaggt atctggctgg ggcgaccatt atcaattagt agctcagaag tcggtactta
      361 aacgtgctat atcaaaacca gtccttgaga aagtggactg gctttgtgtt tggattatta
      421 ccttgaacga taggcgttaa aagttagttg aaccgccgta tgccgaacgg cacgtacggt
      481 ggtgtgagag gggctagaga ttatccccta ctcgatttta aatcacatga cgttcaaagg
      541 catcatctga aatcccttgt tccaagatga gttttgccca ttctttagca gagaagaggc
      601 tgtggtcctt gtagtttccg caagattcga tggttgtccc tgggacatct tcccaagtag
      661 tagtttcagc gatttccttg agcgaatcct tgataacagc tgcgatttta gcactggtgt
      721 gacgtcccca cataatcatg tggaagcctg tgcggcaacc aaatggtgaa cagtcaatca
      781 tgccgtcaat gcgggtacgg atgagtttgg ctaagaggtg ctcgatagtg tgaaggccgg
      841 cagtagggat agagtattcg tttggttgca ccaagcgaat atcataattg gagatgatgt
      901 ctccttttgg tcctgtttct tccccaatca agcgaacata gggtgctttg acaatggtgt
      961 ggtcaagttc aaaactttcg acaataactt cttttgacat ggtaaatcct ttcagttttc
     1021 ttctctcatt atatcataaa ggttgctcct gagacagaga gaaaacctct ccgaggctgg
     1081 agaggttgaa atctttactt acgatataag cggtcgtatt ggtagtatgg gtcaaaggtt
     1141 acgttgatac ccagtttacg aaggacattc ttgtcttcat cagtcaagat gatggttgag
     1201 tgggcttcgc ttcctttgag gttgccgagt tcttccatag cgcgggcagc atcaggattt
     1261 tctgtagctg tgatagcaag tgcaatcagg atttcatttg aatgaaggcg tggattgcgg
     1321 ctaccgagat gatcgatttt aagaccttgg attggcttaa caacttcagg ctcgattagt
     1381 tttacttctt tagcgatgtc agctgatttt ttgatggcgt tgatcaaggc agcggctgta
     1441 ggcccaaaga gttctgagtt cttaccagtg acgatttccc catttggcaa ttcaaaggct
     1501 agggctggtc caccagtttc ttctgctttt tggcgcgcaa cgacagcaac cttacggtct
     1561 gcaggtgaga taccgaggtc gttcatgagc aactcaattt tcttgacggc agcttcgcca
     1621 actttttcag ctttgaagtc aagaactgtt tgatagtaac ggcggatgat ttcttgttta
     1681 gaagcttcga cagcagcctc gtcatctgta atagcgaaac caaccatgtt gacacccata
     1741 tctgtcggtg aagcgtatgg tgattttccg agaatacgtt ccaacatgcg cttgagcact
     1801 gggaagattt cgatatcacg gttgtagttg acagtggttt ctccataggt ttgaagatgg
     1861 aaggggtcaa tcatgttgac atcatcaagg tcagctgtgg cagcttcata agccaagtta
     1921 actggatgat gaaggggaag attccaaaca gggaaggttt caaatttagc gtagccagac
     1981 ttgatgccat tgatttggtc gtggtacata ttggacatac acgttgccaa ttttccagaa
     2041 ccgggtccag gagcggttac gacaatcaag ttgcgactgg ttttgatgta gtcgtttttg
     2101 cccatgcctt ctggggaaat gatgtgatcc atatccgtcg gatatccttt gattggataa
     2161 tgaagataag aatcaattcc gtttttctca agttggttgc ggaaggcatc tgcagcgagt
     2221 tggccagcgt attgtgtaat gacaacggaa ccaacaaaaa tccctaattc attgaatttg
     2281 tcaatcaaac gaagaacttc ttggtcataa gaaatgccta agtcgccacg tgctttggaa
     2341 tgttcaatgt tgctagcatt aatggcaatc acaacctcaa cctgctcttt caattcttgc
     2401 aagagcttga ttttgttgtc aggttcataa ccaggaagga cacgagcagc gtggaaatct
     2461 tctaacattt taccgccaaa ctctaagtag agcttgccgt caaattggtt aatgcgctct
     2521 aagatgtggt cgcgttgtag atttaaatat tgttcagaac taaaagcttg ttttttcatt
     2581 tttttacctc tggactctat tataataaaa aattggaagt taggaaacta cggagctaaa
     2641 aaagaaatta aaaagattaa gcaaacgctt gcacaaaatt ttaaaaagtg ttatcatata
     2701 ctatagatta tgaaaataat gaggtaaaca gatgcaagaa aaatggtggc ataatgccgt
     2761 agtctatcaa gtctatccaa agagttttat ggatagtaat ggagatggag ttggtgattt
     2821 gccaggtatt accagtaagt tggactatct agctaagtta ggaatcacag cgatttggct
     2881 ttctcccgtt tatgacagcc ctatggatga taatggctac gatattgctg attatcaagc
     2941 gattgcaacg atttttggaa ccatggagga tatggatcaa ctgattgcgg aagctaagaa
     3001 gcgtgacatt cgtatcatca tggacttggt ggtcaatcat acctcggatg agcatgcttg
     3061 gtttgtcgaa gcctgtgaaa atactgacag ccctgagcga gactactata tctggcgcga
     3121 tgaacccaat gacctagatt ctatctttag tgggtctgct tgggaatacg atgaaaagtc
     3181 aggtcaatac tatctccact ttttcagcaa gaaacagccg gatctcaact gggaaaatga
     3241 aaaacttcgc cagaaaattt atgagatgat gaacttctgg attgataaag gtattggtgg
     3301 tttccgtatg gatgttattg acatgattgg caaaattcct gacgagaagg tagtcaataa
     3361 tggtcctatg ctccatccct atctcaagga aatgaatcag gcgacctttg gagataagaa
     3421 tctcttgaca gtaggggaga cttggggagc aacgccagag attgccaagc tctactctga
     3481 tccaaagggg caagaattgt ctatggtctt ccagtttgaa catatcggtc ttcagtatca
     3541 ggaaggtcag cctaaatggc actatcaaaa agagctgaat atcgctaagt taaaagaaat
     3601 cttcaacaaa tggcagacag agttaggagt tgaggacggc tggaattccc tcttctggaa
     3661 caaccatgac ctccctcgta ttgtctcaat atggggaaat gaccaagaat accgcgaaaa
     3721 atctgccaaa gcctttgcaa tcttgcttca tcttatgaga ggaactcctt atatctacca
     3781 aggtgaggag attgggatga ccaactatcc gtttgaaaca ctggatcaag tagaagatat
     3841 tgaatctctc aactatgcgc gtgaggctct tgaaaaaggt gttccgattg aagaaatcat
     3901 ggacagtatc cgtgttattg gacgtgacaa tgcccgtacc cctatgcaat gggacgagag
     3961 caaaaacgct ggtttctcaa caggtcaacc ttggttggcg gttaatccaa attacgagat
     4021 gatcaacgtc caagaagcgc tggcaaatcc agattctatt ttctatacct atcagaaact
     4081 ggtccaaatt cgcaaggaga atagctggct aattcgagct gactttgaat tgcttgatac
     4141 ggctgataag gtctttgctt atatacgtaa ggatggcgac cgtcgcttcc tagttgtggc
     4201 taacttgtct aatgaagagc aagacttgac agtagaagga aaagtcaaat ctgtcttgat
     4261 tgaaaacacc ctagctcaag aagtctttga aaaacaaatc ttagttccat gggatgcttt
     4321 ctgtgtggaa ttactataaa tattttttgc agaaaaattt aaaattgaaa tcgtataaaa
     4381 acaagggagg actgtataaa agacagaaat cctttgtttt ttataaccaa ggtttataaa
     4441 ctttcattct cgaaattcaa ttaactttac aaattcccac tattaaggag aaagaagatg
     4501 aacataaaga agcgtgtcct tagtgcaggt ctgacttttg catctgcttt gcttttagct
     4561 gcttgcgacc aatcaggttc agatacaaaa acttactcat caacctttag tggaaatcca
     4621 actacattta attacctatt agactattaa actgataata tagtcaatcg aaacaagaac
     4681 aagacaaaag agccttgtaa aaggtattgc aacttggtaa taccttttat gaggtgcttt
     4741 ttgatatgag tccatgtttt ctcaatagga ttgtactcag gtgagtaggg aggaagaggt
     4801 aaaagtttat tcccaaactc ttcacacaag agttctagct tccccattct atggaatctt
     4861 acattatcca taataataac cgatggtgtg gttaatgttg gtaagaaaaa cttctgaaac
     4921 catacttcaa aaaagtcgct cgtcatcgtc tcttcgtaag tcattggagc gattaactca
     4981 ccatttgtta gacctgcaac caaagaaatc ctctgatatc ttcttccaga tactttacct
     5041 cttattaact gaccttttaa tgagcgacca tattctcgat aaaaataagt atcgaatcct
     5101 gtttcgtcaa tctaaacagg tgctaggtgc tttaatctat taaaattctt aagaaataag
     5161 gctacttttt ctgggtcttg ttcataatta gattgaaact agaatagtac acctctgctt
     5221 ctaaaacatt gttagaaatc gatttgactg tcctgatcga tttatcatgt tcttatttca
     5281 ttttactata tttttgtttc gcgggaagtc tactaagata cttaaagatg cagatagtga
     5341 aaaaaggtgt agacattacc gtaaaaaagt gatataatcg tatgatgttc aatgtatagg
     5401 tgttaatcat gagtagacgt tttaaaaaat caagttcaca gaaagtgaag cgaagtgtta
     5461 atatagtttt gttgactatt tatttattgt tagtttgttt tttattgttc ttaatcttta
     5521 agtacaatat ccttgctttt agatatctta atttagtggt aactgcgtta gtcctactag
     5581 ttgccttggt agggctactc ctgattatct ataaaaaagc tgaaaaattt actatttttc
     5641 tgttggtgtt ctctatcctt gtcagctctg tgtcgctctt tgcagtacag cagtttgttg
     5701 gactgaccaa tcgtttaaat gcgacttcta attactcaga atattcaatc agtgtcgctg
     5761 ttttagcaga tagtgatatc gaaaatgtta cgcaactgac gagtgtgaca gcaccgactg
     5821 ggactgataa tgaaaatatt caaaaactac tagctgatat taagtcaagt cagaataccg
     5881 atttgacggt cgaccagagt tcgtcttact tggcagctta caagagtttg attgcagggg
     5941 agactaaggc cattgtctta aatagtgtct ttgaaaatat cattgagtca gagtatccag
     6001 actacgcatc gaagataaaa aagatttata ccaagggatt cactaaaaaa gtagaagctc
     6061 ctaagacgtc taagaatcag tctttcaata tctatgttag tggaattgac acctatggtc
     6121 ctattagttc ggtgtcgcga tcagatgtca atatcctgat gactgtcaat cgagatacca
     6181 agaaaatcct cttgaccaca acaccacgtg atgcctatgt accaatagca gatggtggaa
     6241 ataatcaaaa agataaatta acccatgcgg gcatttatgg agttgattcg tccattcaca
     6301 ccttagaaaa tctctatgga gtggatatca attactatgt gcgattgaac ttcacttctt
     6361 tcttgaaaat gattgactta ttgggagggg tagatgttca taatgatcaa gagttttcag
     6421 ctctacatgg gaagttccat ttcccagtag ggaatgtcca tctagactct gagcaggctc
     6481 taggttttgt acgtgaacgc tactcactag ccgatggaga ccgtgaccgt ggtcgcaacc
     6541 aacaaaaggt gattgtggct atccttcaaa aattaacgtc aaccgaagca ctgaaaaatt
     6601 atagtacgat cattaatagc ttgcaagatt ctatccaaac aaatatgcca cttgagacta
     6661 tgataaattt ggtcaatgct cagttagaaa gtggagggaa ttataaagta aattctcaag
     6721 atttaaaagg gacaggtcgg acggatcttc cttcttatgc aatgccagac agtaacctct
     6781 atgtgttgga aatagatgat agtagtttag ctgtagttaa agcagctata caggatgtga
     6841 tggagggtag atgaaatgat agacatccat tcgcatatcg tttttgatgt agatgacggt
     6901 cccaagtcaa gagaggaaag caaggctctc ttggcagaat cctacaggca aggggtacga
     6961 atcattgtct ctacctctca ccgtcgcaag ggcatgtttg aaactccgga agagaagata
     7021 gcagaaaact ttcttcaggt tcgggaaata gctaaggaag tggcgagtga cttggtcatt
     7081 gcttacggag ctgaaattta ctacacacca gatgttctgg ataagctgga aaaaaagcgg
     7141 attccgaccc tcaatgatag tcgttatgcc ttgatagagt ttagtatgaa cactccttat
     7201 cgcgatattc atagcgcctt gagcaagatc ttgatgttgg gaattactcc agtcattgcc
     7261 cacattgagc gctatgatgc tcttgaaaat aatgaaaaac gcgttcgaga actgatcgat
     7321 atgggctgtt acacgcaagt aaatagttca catgtcctca aacccaaact ttttggcgaa
     7381 cgttataaat tcatgaaaaa aagagctcag tattttttgg aacgtgattt agttcatgta
     7441 gttgcaagtg acatgcacaa tttagacagt agacctccat atatgcaaca ggcatatgat
     7501 atcattgcta agaaatatgg agcgaaaaaa gcgaaagaat tttttgtaga taatcccaga
     7561 aaaattataa tggatcaatt aatttaggag aaaatatgaa ggaacacaac actttggaaa
     7621 tcgatatatt gcaactattc agagctttat ggaaaagaaa gttggtcatt ttattagtgg
     7681 caattataac ttcttcagtt gcttttgcct acagtacttt tgttatcaaa cctgagttta
     7741 ctagtacgac tcggatttat gtagttaacc gtaatcagga agagaagtct ggtttaacca
     7801 atcaagactt gcaggcagga acttatctgg taaaagacta ccgtgagatt atcctttcgc
     7861 aggatgtttt ggaggaagtt atttctgatt tgaaactaga tttgacgcca aaaggtttgg
     7921 ctaataaaat taaagtaaca gtaccagttg atacccgtat tgtctctgtt tcagttaatg
     7981 atcgagttcc tgaagaggca agccgtatcg ctaactcttt gagagaagta gctgctcaaa
     8041 aaattatcag tattactcgt gtttctgatg tgacaacact ggaggaggca agaccggcga
     8101 tatcaccgtc ttcgccaaat attaaacgca atatactaat tggttttttg gcaggggggg
     8161 ttggaactgg tgttatagtt cttcttcttg aacttttgga cactcatgtg aaacgtccgg
     8221 aagatatcga agatacactg cagatgacac ttttgggagt tgtaccaaac ttgagtaagt
     8281 tgaaatagga gagaggaatg ccgacattag aaatagcaca aaaaaaactg gagttcatta
     8341 agaaggcaga agaatattac aatgccttgt gtacaaatat acagttgagc ggagataaac
     8401 taaaagtaat ttccgttact tctgttaacc ctggggaagg aaaaacaact acttccgtaa
     8461 atatagcaag gtcgtttgcg cgtgcaggct ataaaactct tttgatcgat ggcgatactc
     8521 gaaattcagt tatgtcagga ttttttaaat ctcgtgaaaa aattacaggg ctaacagaat
     8581 ttttatctgg gacagctgat ttatctcacg gtttatgtga tacaaatatt gaaaatttat
     8641 ttgtagttca atcggggtct gtatcaccaa accctacagc cttgttacaa agtaaaaatt
     8701 ttaatgatat gattgaaaca ttgcgtaaat attttgatta tatcattgtt gatacagcac
     8761 ctattggaat tgttattgat gcggcaatta tcactcaaaa gtgtgatgcg tccatcttgg
     8821 taacagcaac aggtgaggtg aataaacgtg atgtccaaaa agcgaaacaa caattagaac
     8881 aaacagggaa actgttttta ggtgtcattc tcaataaatt tgatgttcaa cataaaaaat
     8941 atggttctta cggtgactat ggtaattatg gtaaaaaata acttaggaaa gattttatgg
     9001 atgaaaaagg attgaaaatt tttctggcag tattacagag tattattgtc attttattgg
     9061 tttattttct tagctttgtt agagagacag aacttgaacg ttcttcgatg gttatactat
     9121 accttctcca cttttttgta ttctatttta gttcctatgg taataatttt tttaaaagag
     9181 ggcacttagt tgagtttaat agtactataa gatatatttt tttctttgca atagctataa
     9241 gtgtattaaa cttttttata gcggaacggt ttagtatctc tagaagagga atggtatact
     9301 tcttaacttt agaaggaata tccttatact tgttaaattt cttagtaaag aaatattgga
     9361 agcatgtgtt ttttaatcta aaaaatagca agaaaatttt actgttaaca gtaacgaaaa
     9421 atatggaaaa agttcttgat aaattgctag aatctgatga actttcatgg aaattggtag
     9481 cagtaagtgt tttggataaa tctgattttc aacatgataa aatacctgta attgaaaagg
     9541 aaaaaattat tgaatttgca acgcatgaag ttgtggatga ggtgtttgtc aatcttccag
     9601 gagagagcta cgatattgga gaaattatct ctaggtttga gacaatgggg atagatgtaa
     9661 ctgtaaatct taaagcattt gataagaatt tgggtcgcaa taaacaaatt catgagatgg
     9721 taggattgaa tgtagtcact ttctctacaa atttttataa aactagtcat gtgatttcaa
     9781 agagaattct cgatatttgt ggtgccacta ttggccttgt tctttttgct atagctagtc
     9841 tagttttagt tccattgatt cgtaaagatg gcggaccagc tatttttgct caaactcgta
     9901 tagggaaaaa tggtcgacat tttacctttt ataaattccg ttcgatgagg atcgatgctg
     9961 aagctatcaa agaacagttg atggatcaaa atacgatgca aggtggtatg tttaagatgg
    10021 acaatgatcc tcgtgttaca aaaattggtc gctttattcg taaaaccagt ttggatgaat
    10081 tgccgcagtt ttggaatgtc tttataggag atatgagttt ggtgggaaca cgtccaccta
    10141 cagtagacga gtatgatcag tatactccag aacagaaacg tcgactcagc tttaaacctg
    10201 gtattacagg tttatggcag gttagcggcc gtagtaaaat aaccgatttt gacgatgttg
    10261 taaaattaga tgtggcttat attgataatt ggacaatctg gaaagatatt gaaattttgc
    10321 ttaaaactgt taaagttgta tttataagag atggagcgaa gtaaggaatg aaagtatgtc
    10381 tagttggatc tagtggaggc catttaactc atttgtattt attaaaacct ttctggaatg
    10441 ataaagaaag attttgggtt acttttgata aggcggacgc tcggagtgta ctctctgagg
    10501 aagttgtata tccctgttat tatccaacca atcgtaatat aaaaaattta ataaaaaata
    10561 cttttctcgc ctataaaatt ttaaaaaaag agagaccaga tttgattatt tcttctggtg
    10621 ccgctatcgc tgttcctttc ttttatattg ggaagttatt tggatcaaag acagtgtata
    10681 tagaagtgtt tgatagaatt gatgcttcaa cactgacagg aaaacttgtt tatccagtaa
    10741 cggataggtt tattgtacaa tgggaagaaa tgaaaaaagt atacccaaaa gcaattaacc
    10801 taggagggat attctaatga tttttgtgac tgtaggtaca cacgaacaac aatttgatcg
    10861 attgattaaa gaagttgatt atctaaaaaa agaaaatctt attcaagatg aagtatttat
    10921 tcaaatagga tattccagtt atattccgaa atattgtgag tgggaaaaga taatttctta
    10981 tgaaaaaatg aatcaattga ttaaggaatc agatattatc attactcatg gtggaccagc
    11041 gacgtttatg ggggttattg ctaaaggaaa agttccgata gttgttccga ggcaaaaaaa
    11101 atttggagag catgtgaatg accatcagct tcaattcgta aaactgacga aagaaatata
    11161 caattttata gtcatagatg atatttccga cttatattta agtatacgtg attttaagga
    11221 taaatatttt ggaatttgtt tgaacaatga aagatttaat ctacatttta atgcggaaat
    11281 taataaacta tttg
//
LOCUS       DAVLHC010000054        10952 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.055, whole genome shotgun sequence.
ACCESSION   DAVLHC010000054 DAVLHC010000000
VERSION     DAVLHC010000054.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10952)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10952)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10952
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.055"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            11..733
                     /locus_tag="VXE25_001773"
     CDS             11..733
                     /locus_tag="VXE25_001773"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter ATP-binding protein"
                     /protein_id="HEV0772194.1"
                     /translation="MIRIENLSVSYKETLALKDISLVLHGPTITGIIGPNGAGKSTLL
                     KGMLGIIPHQGQAFLDDKEVKKSLHRIAYVEQKINIDYNFPIKVKECVSLGLFPSIPL
                     FRSLKAKHWKKVQEALEIVGLADYAERQISQLSGGQFQRVLIARCLVQEADYILLDEP
                     FAGIDSVSEEIIMNTLRDLKKAGKTVLIVHHDLSKIPHYFDQVLLVNREVIAFGPTKE
                     TFTETNLKEAYGNQLFFNGGDL"
     gene            730..1578
                     /locus_tag="VXE25_001774"
     CDS             730..1578
                     /locus_tag="VXE25_001774"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000559784.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter permease"
                     /protein_id="HEV0772195.1"
                     /translation="MIAEFIDGLQKFHFLQNALITAIVVGIVAGAVGCFIILRGMSLM
                     GDAISHAVLPGVALSFILGLDFFIGAIVFGLLAAIIITYIKGNSIIKSDTAIGITFSS
                     FLALGIILIGVAKSSTDLFHILFGNILAVQDTDMFITMGVGAAILLLIWIFFKQLLIT
                     SFDELLAKAMGMPVNFYHYLLMVLLTLVSVTAMQSVGTILIVAMLITPAATAYLYANS
                     LKSMIFLSSTFGATASVLGLFIGYSFNVAAGSSIVLTAASFFLISFFIAPKQRYLKLK
                     NKHLLK"
     gene            1610..2539
                     /gene="psaA"
                     /locus_tag="VXE25_001775"
     CDS             1610..2539
                     /gene="psaA"
                     /locus_tag="VXE25_001775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000733059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter substrate-binding
                     lipoprotein/adhesin PsaA"
                     /protein_id="HEV0772196.1"
                     /translation="MKKLGTLLVLFLSAIILVACASGKKDTTSGQKLKVVATNSIIAD
                     ITKNIAGDKIDLHSIVPIGQDPHEYEPLPEDVKKTSEADLIFYNGINLETGGNAWFTK
                     LVENAKKTENKDYFAVSDGVDVIYLEGQNEKGKEDPHAWLNLENGIIFAKNIAKQLSA
                     KDPNNKEFYEKNLKEYTDKLDKLDKESKDKFNKIPAEKKLIVTSEGAFKYFSKAYGVP
                     SAYIWEINTEEEGTPEQIKTLVEKLRQTKVPSLFVESSVDDRPMKTVSQDTNIPIYAQ
                     IFTDSIAEQGKEGDSYYSMMKYNLDKIAEGLAK"
     gene            2662..3153
                     /gene="tpx"
                     /locus_tag="VXE25_001776"
     CDS             2662..3153
                     /gene="tpx"
                     /locus_tag="VXE25_001776"
                     /EC_number="1.11.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004245092.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol peroxidase"
                     /protein_id="HEV0772197.1"
                     /translation="MVTFLGNPVSFTGKQLQVGDKALDFSLTTTDLSKKSLADFDGKK
                     KVLSVVPSIDTGICSTQTRRFNEELAGLDNTVVLTVSMDLPFAQKRWCGAEGLDNAIM
                     LSDYFDHSFGHDYALLINEWHLLARAVFVLDTDNTIRYVEYVDNINSEPNFEAAIAAA
                     KAL"
     gene            complement(3249..5957)
                     /locus_tag="VXE25_001777"
     CDS             complement(3249..5957)
                     /locus_tag="VXE25_001777"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000595876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HEV0772198.1"
                     /translation="MIKRKTYWKDLIQSFTGSKGRFLSILILMMLGSLALVGLKVTSP
                     NMEATANAYLTTAQTLDLAVMSNYGLDQADQEELKQTEGAEVEFGYLTDVTMDNGQDA
                     IRLYSKPERISTFQLRKGRLPQSDKEIALATHLQGQYSVGQEISFKEKEEGHSSLKDH
                     TYTITGFVDSAEILSQRDMGYAGSGSGTLTAYGVILPSQFDQKVYNIARLKYQDLAGL
                     NAFSSAYEEKSKQHQEELEQILSDNGKVRLQLLKKEGQESLDKGQETLDKAQTNLQEG
                     KRRLAAAQARIQAQESQLALFPQVQREQASAQLTQAKQELGKEEAKLKQAEQNLAQEN
                     EKLEKHQQVLDDLAEPRYQVYNRQTMPGGQGYLMYSNASSSIRAVGNIFPVVLYAVAA
                     MVTFTTMTRFVDEERTHAGIFKALGYRSKDIIAKFLLYGLVAGTVGTALGSILGHYLL
                     ASVISSVITKGMVVGETQIQFYWTYSLLALVLSLLASVLPAYLVAWRELHDEAAQLLL
                     PKPPVKGAKILLERIGFIWRRLSFTHKVTARNIFRYKQRMLMTIFGVAGSVALLFAGL
                     GIQSSVAGVPSKQFQQIQQYQMLVSENPSATNQDKVELAEVLKGQEILAYQKIYSKTL
                     DKDFKGKAGLQNITLMMIEKEDLTPFIHLQHHQQELTLKDGIVITAKLAQLAGVKVGQ
                     TLEIEGKELKVAAITENYVGHFIYMSQASYEQLYGQLPQANTYLVSLRDTSATSIESQ
                     AGLLMNQSAVSSVVQNASAIRLFDSIASSLNQTMTILVIVSVLLAIVILYNLTNINVA
                     ERIRELSTIKVLGFHNNEVTLYIYRETIVLSLVGIVLGLIAGFYLHQFLIQMISPATI
                     LFYPQVGWEVYVIPVAAVSIILTLLGFFVNYYLRKVDMLEALKSVE"
     gene            complement(5959..6660)
                     /locus_tag="VXE25_001778"
     CDS             complement(5959..6660)
                     /locus_tag="VXE25_001778"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0772199.1"
                     /translation="MAYIEMKHCYKRYQVGDTEIVANRDVNFEIEKGELVIILGASGA
                     GKSTVLNLLGGMDTNDEGEIWIDGVNIADYSSHQRTNYRRNDVGFVFQFYNLVSNLTA
                     KENVELASEIVTDALNPDQVLTDVGLAHRLNNFPAQLSGGEQQRVSIARAVAKNPKIL
                     LCDEPTGALDYQTGKQVLKILQDMSRQKGATVIIVTHNGALAPIADRVIHMHDASVKD
                     VVLNQHPQDIDSLEY"
     gene            complement(6910..9321)
                     /locus_tag="VXE25_001779"
     CDS             complement(6910..9321)
                     /locus_tag="VXE25_001779"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000620712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 95 protein"
                     /protein_id="HEV0772200.1"
                     /translation="MIRNKKQDYVLAYKQPASTTYMGWEEEALPIGNGSLGAKVFGLI
                     GAERIQFNEKSLWSGGPLPDSSDYQGGNLQDQYVFLAEIRQALEKRDYNLAKELAEQH
                     LIGPKTSQYGTYLSFGDIHIEFSQQGTTLSQVTDYQRQLNISKALATTSYVYKGTRFE
                     REAFASFPDDLLVQCFTKEGLETLDFTIELSLTCDLASNGKYEQEKSDYKECKLDITD
                     SHILMKGRVKDNDLRFASYLAWETDGDIRVWSDRVQISGASYANLFLAAKTDFAQNPA
                     SNYRKKLDLEQQVIDLVDTAKEKGYTQLKSRHIEDYQALFQRVQLDLEADVDASTTDD
                     LLKNYKPQEGQALEELFFQYGRYLLISSSRYCPDALPANLQGVWNAVDNPPWNSDYHL
                     NVNLQMNYWPAYVTNLLETVFPVINYVDDLRVYGRLAAVKYAGIVSQKGEENGWLVHT
                     QATPFGWTAPGWDYYWGWSPAANAWMMQTVYEAYSFYRDQDYLREKIYPMLRETVRFW
                     NAFLHKDQQAQRWVSSPSYSPEHGPISIGNTYDQSLIWQLFHDFIQAAQELGLDEDLL
                     TEVKEKSDLLNPLQITQSGRIREWYEEEEQYFQNEKVEAQHRHASHLVGLYPGNLFSY
                     KGQEYIEAARASLNDRGDGGTGWSKANKINLWARLGDGNRAHKLLAEQLKTSTLPNLW
                     CSHPPFQIDGNFGATSGMAEMLLQSHAAYLVPLAALPDAWSTGSVSGLMARGHFEVSM
                     SWEDKKLLQLTILSRSGGDLRVSYPDIEKSVIKMNQEKIKAKCMGKDCISVATAEGDL
                     VQFYF"
     gene            complement(9374..10066)
                     /locus_tag="VXE25_001780"
     CDS             complement(9374..10066)
                     /locus_tag="VXE25_001780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006703946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglycerate mutase"
                     /protein_id="HEV0772201.1"
                     /translation="MVKLVFARHGESEWNKANLFTGWADVDLSEKGTQQAIDAGKLIK
                     EAGIEFDQAYTSVLKRAIKTTNLALEASDQLWVPVEKSWRLNERHYGGLTGKNKAEAA
                     EQFGDEQVHIWRRSYDVLPPNMDRDDEHSAHTDRRYASLDDSVIPDAENLKVTLERAL
                     PFWEDKIAPALKDGKNVFVGAHGNSIRALVKHIKGLSDDEIMDVEIPNFPPLVFEFDE
                     KLNVVSEYYLGK"
     gene            complement(10602..10937)
                     /locus_tag="VXE25_001781"
     CDS             complement(10602..10937)
                     /locus_tag="VXE25_001781"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000508814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772202.1"
                     /translation="MGGILLLICPFVLLGTAVNTAATTLNGGATAGAFSGVALLLNTL
                     KIANLVLGIIAIVYYKGDKHVGAAPSVLMIVSGEVSLIPFLGWVGGILAIIGGSLFLA
                     TLKKFKSEE"
BASE COUNT         3202 a         2515 c         2049 g         3186 t
ORIGIN      
        1 atacaagttt atgatacgta tcgaaaacct cagtgtctcc tacaaagaaa cgttggcact
       61 taaggatatt tcactagtgc tccatggacc aacaattacc ggcatcattg gtccaaacgg
      121 cgctgggaaa tcaacactat taaaaggtat gttgggaatt atcccacatc aaggtcaggc
      181 atttctcgat gacaaggaag ttaaaaaatc cttacaccga attgcctatg tcgaacaaaa
      241 aatcaatatc gactacaact ttcccatcaa ggtcaaggaa tgcgtctcgt taggactatt
      301 tccctctatt cctctctttc gaagtttaaa ggctaaacat tggaagaaag tgcaagaggc
      361 ccttgaaatc gtcggcctag ctgactacgc tgaacgtcaa attagtcaac tgtctggagg
      421 tcaattccag cgggtcttga ttgccagatg tttggtgcag gaagccgact atatcctctt
      481 ggatgaaccc tttgctggga ttgactctgt cagtgaggaa atcatcatga atacgctgag
      541 agatttgaaa aaagctggga agacggttct catcgttcac cacgacctca gcaagattcc
      601 ccactacttc gatcaagtct tacttgtcaa tcgagaagtg attgcctttg gtccaacaaa
      661 agaaactttt accgaaacca atctaaaaga agcttacggt aatcaactct ttttcaatgg
      721 aggtgaccta tgattgcaga atttatcgat ggattgcaaa aattccattt cctacaaaat
      781 gccttgataa cagctattgt cgtcgggatt gtagctggag ccgtgggatg tttcattatt
      841 ctacgcggga tgtcactcat gggagatgcc atttcacatg ctgtcttacc aggtgtagcc
      901 ctctccttca tcttgggcct tgacttcttt atcggagcca ttgtctttgg attgctagct
      961 gccatcatca ttacctacat caaaggaaac tcgattatca aaagcgatac cgccatcggc
     1021 attacctttt cttctttctt agccctcggt atcatcttga ttggtgtcgc taaaagttca
     1081 actgaccttt tccatatcct ttttggtaat atcctggccg tccaagatac ggatatgttt
     1141 attactatgg gtgtgggggc agccatcctc ttgttaattt ggattttctt caagcaactc
     1201 ttgataactt cctttgatga actcttggct aaagccatgg gaatgcctgt caatttctat
     1261 cactaccttc tcatggtact cctgactctc gtgtctgtga cagccatgca aagtgtcgga
     1321 actatcctga ttgtagccat gctgattacc ccagctgcaa ctgcttatct gtatgctaat
     1381 agtctgaaaa gtatgatttt cctttcctca accttcggag ctactgcttc agttttggga
     1441 ctctttattg gctatagttt taatgttgcg gcaggttcta gtatcgtgct tacagctgct
     1501 agtttctttc tcattagctt ctttatcgct cccaaacaac gatatttgaa actgaaaaat
     1561 aaacatttgt taaaataagg ggcaaagccc taataaattg gaggatctaa tgaaaaaatt
     1621 aggtacatta ctcgttctct ttctttctgc aatcattctt gtagcatgtg ctagcggaaa
     1681 aaaagataca acttctggtc aaaaactaaa agttgttgct acaaactcaa tcatcgctga
     1741 tattactaaa aatattgctg gtgacaaaat tgaccttcat agtatcgttc cgattgggca
     1801 agacccacac gaatacgaac cacttcctga agacgttaag aaaacttctg aggctgattt
     1861 gattttctat aacggtatca accttgaaac aggtggcaat gcttggttta caaaattggt
     1921 agaaaatgcc aagaaaactg aaaacaaaga ctacttcgca gtcagcgacg gcgttgatgt
     1981 tatctacctt gaaggtcaaa atgaaaaagg aaaagaagac ccacacgctt ggcttaacct
     2041 tgaaaacggt attatttttg ctaaaaatat cgccaaacaa ttgagcgcca aagaccctaa
     2101 caataaagaa ttctatgaaa aaaatctcaa agaatatact gataagttag acaaacttga
     2161 taaagaaagt aaggataaat ttaataagat ccctgctgaa aagaaactca ttgtaaccag
     2221 cgaaggagca ttcaaatact tctctaaagc ctatggtgtc ccaagtgcct acatctggga
     2281 aatcaatact gaagaagaag gaactcctga acaaatcaag accttggttg aaaaacttcg
     2341 ccaaacaaaa gttccatcac tctttgtaga atcaagtgtg gatgaccgtc caatgaaaac
     2401 tgtttctcaa gacacaaaca tcccaatcta cgcacaaatc tttactgact ctatcgcaga
     2461 acaaggtaaa gaaggcgaca gctactacag catgatgaaa tacaaccttg acaagattgc
     2521 tgaaggattg gcaaaataag cctctgaaaa acgtcattct catgtgagct ggcgtttttt
     2581 ctatgcccac atttccggtc aaatcattgg aaaattctga ctgtttcaga tacaatggaa
     2641 gaaaaaagat tggagtatcc tatggtaact tttctcggaa atcctgtgag ctttacaggt
     2701 aaacaactac aagttggcga caaggcgctt gatttttctc ttactacaac agatctttct
     2761 aaaaaatctc tggctgattt tgatggcaag aaaaaagtct tgagtgtcgt tccttctatc
     2821 gatacaggca tctgctcaac tcaaacacgt cgttttaatg aagaattggc tggactggac
     2881 aacacggtcg tattgactgt ttcaatggac ctaccttttg ctcaaaaacg ttggtgcggt
     2941 gctgaaggcc ttgacaatgc cattatgctt tcagactact ttgaccattc tttcgggcac
     3001 gattatgccc tcttaatcaa cgaatggcac ctattagcac gcgcagtctt tgtcctcgat
     3061 actgacaata cgattcgcta cgttgaatac gtggataata tcaattctga gccaaacttc
     3121 gaagccgcaa ttgcagctgc taaagcccta tagaaaaaat cctctgtcac aaagagttcc
     3181 ctgctctttg aaacggagga tttttgaata ttagtaaata gaagttcaat cagctaaaaa
     3241 taactacctt actctacaga tttcagagct tctaacatat caacctttct cagataataa
     3301 ttgacgaaga aaccaagcaa ggtcaaaatg atgcttactg ctgccactgg gattacatag
     3361 acttcccagc ctacctgcgg ataaaagaga atagtcgcag gcgaaatcat ttgaatcaaa
     3421 aattggtgta aatagaaacc agctatcaga ccaagtacga ttcccacaag ggacagcaca
     3481 atcgtctcac ggtaaatgta gagtgtgact tcattattat gaaaaccgag aaccttgata
     3541 gtggagagtt cacggattct ctcagctacg ttgatattgg tcagattgta aaggatgaca
     3601 atagctaata gaacagatac gatgaccaag atggtcatgg tctgattgag tgagctagcg
     3661 atagagtcga agagtcgaat ggctgaagca ttttggacaa cgctggacac cgcagattga
     3721 ttcataagca agcccgcctg actttcgata ctagttgcac tggtatccct taatgagacc
     3781 agataagtgt tggcttgggg tagctgtccg taaagttgct catagctagc ctgactcata
     3841 taaataaagt gaccaacgta gttctcagta atagcagcga cctttagttc cttaccttca
     3901 atttctaaag tctgcccaac cttgacacct gccagctggg cgagtttagc tgtaataacg
     3961 atgccatctt ttaatgtcag ctcctgctga tgatgttgaa gatggataaa gggagtcaaa
     4021 tcttccttct ctatcatcat aagagtaatg ttttgaagac cagccttgcc tttgaaatcc
     4081 ttgtctagcg ttttagaata gattttctgg taggctagta tctcctgccc tttcaacact
     4141 tctgctagct ctaccttgtc ctgattggtc gcactaggat tttcagagac aagcatctga
     4201 tactgttgga tttgttgaaa ctgtttagac ggaactcctg ctacagaaga ttggattccc
     4261 aaacctgcaa agagcagagc tacagaacct gccacaccaa agattgtcat caacattctc
     4321 tgcttataac gaaagatgtt gcgggctgtt accttatgag taaaactgag acgacgccag
     4381 ataaaaccga tacgctccaa taagatttta gctcctttga caggaggttt aggaagtaga
     4441 agctgggctg cttcgtcatg aagttccctc caagccacca gataggctgg taacacactc
     4501 gccaacaagc tcaagacaag agctagtaag ctataggtcc aatagaactg aatctgagtt
     4561 tctcccacca ccatgccttt tgtaatgaca cttgaaatta cactggctag caaataatga
     4621 ccaagtatac tacctagagc cgttccgaca gtcccagcta ctagtccata aaggagaaac
     4681 ttggcgataa tatccttact acgataaccc aaggccttaa aaatccctgc atgagttcgc
     4741 tcttcgtcta caaagcgagt catggtcgta aaggtcacca tggctgctac ggcataaagt
     4801 accacaggaa agatattgcc cactgctcga atactggatg aagcattgct atacataaga
     4861 tagccctgac cacctggcat ggtctgacga ttatagacct gataccttgg ctccgccaaa
     4921 tcgtccaaga cttgctgatg tttttctaat ttttcatttt cttgggctag attttgttca
     4981 gcttgcttta gtttggcctc ttccttgccc aattcctgct tggcttgggt aagttgagca
     5041 ctagcctgct ctctctgaac ttgaggaaac aaggctagtt gactttcttg agcctgtata
     5101 cgagcttgag cagctgctaa acgacgcttg ccttcctgca aattagtctg agccttgtca
     5161 agggtctctt gccccttgtc tagagactct tgtccttctt ttttcaaaag ttgcagacgt
     5221 accttgccat tatctgataa aatttgttca agctcttcct gatgttgctt ggatttttct
     5281 tcataagctg atgaaaaggc atttaaacct gctaaatctt gatatttcaa acgagctata
     5341 ttgtagactt tctgatcaaa ctgactaggt aaaatcaccc cataggctgt cagagtccca
     5401 cttccacttc ctgcgtagcc catatctcgc tgggagagga tttcagccga atccacaaaa
     5461 ccagtaatgg tataagtatg gtcttttaaa gaggaatgac cctcttcttt ttctttaaaa
     5521 ctaatctcct gtcccacgct gtattggcct tgcaaatgag tggccaaagc gatttccttg
     5581 tctgactgag gaagtcgtcc ctttcttagc tgaaaggttg aaattcgctc tggtttggag
     5641 tacagccgaa tggcatcctg cccattatcc atagtcacat ctgtcaaata gccaaactcg
     5701 acctctgcgc cctccgtctg ttttagttct tcttggtctg cttgatccaa gccatagtta
     5761 gacatgactg ccaaatccaa ggtttgagca gttgttaaat aagcattagc tgtcgcctcc
     5821 atgttgggac tggttacttt gaggcctact aaggctagag atcccaacat catcaggatc
     5881 aagatggata aaaaacgccc cttggagcct gtgaaggact gaattaagtc cttccaataa
     5941 gtttttcgct tgatcatact agtactccaa actgtcaata tcctgaggat gctggttgag
     6001 caccacatcc ttgacactgg catcgtgcat atgaatcacg cgatcagcaa tgggcgccaa
     6061 agctccatta tgagtcacga tgatcaccgt cgctcccttt tgacgagaca tatcttggag
     6121 aattttcaaa acctgcttgc ccgtctgata atccaaggct ccagtaggtt catcacaaag
     6181 aagaatttta ggatttttgg ctaccgcgcg tgcaatggag actcgctgtt gctcccctcc
     6241 agaaagctgg gctggaaagt tattgagacg atgagccaga cctacatctg tcaagacctg
     6301 atcaggattc aaggcatctg tcacaatttc agaagccaat tccacatttt ccttagctgt
     6361 cagattagaa actagattat aaaactgaaa aacaaacccc acatcatttc tacggtaatt
     6421 ggtgcgctgg tgggaactat aatccgcaat attaacacca tcaatccaga tttccccttc
     6481 atcattggta tccattcccc caagaaggtt aagaactgtt gacttacctg cacctgaagc
     6541 accaaggata ataaccagct cccccttttc aatctcaaaa ttcacatcac gattggccac
     6601 aatctccgtg tccccaacct gataacgctt gtaacagtgt ttcatctcaa tataagccat
     6661 cagacccacc ctctatcaaa caaattatac tcctcgaaaa tctctcttca aaccacgtca
     6721 gcttccatct gcaacctcaa aacactgttt tgagcaacct gcggctagct tcctagtttg
     6781 tgctctttga ttttcattga gtattacttc ctattatcat tataacgctt tttcaactag
     6841 ttggaaactg cttacattct taaatcctta ttaaaaggca gtttcaaatt actgccttat
     6901 aacatcttct taaaaataaa attgaacaag atcaccttct gctgttgcca ccgaaataca
     6961 atctttcccc atgcatttcg cttttatttt ttcttgattc attttaatca cactcttctc
     7021 aatatctgga taagaaactc gcaaatctcc tccactcctt gataaaatgg tcaactgtaa
     7081 gagtttttta tcttcccagc tcatgctcac ttcaaaatgt ccacgtgcca ttaagcctga
     7141 aacagaacct gttgaccaag catcaggtaa ggcagctaga ggtaccagat aagctgcatg
     7201 agactggagt aacatttctg ccatgccact agtagcacca aaattaccat ctatctgaaa
     7261 aggaggatgg ctacaccaaa gatttggcaa ggtggatgtc tttaactgct ctgccaataa
     7321 tttatgggct cgattaccat ctcccaaacg cgcccagaga ttgatcttat tagccttgga
     7381 ccagcctgtg ccgccatctc cacgatcatt gaggctagca cgcgccgctt caatatactc
     7441 ttgtcccttg tagctaaaga gattgccagg atagagtccc actagatggg aagcgtgccg
     7501 atgctgggcc tccactttct cattttgaaa atactgctct tcctcctcat accactccct
     7561 gattcgacca gattgagtga tttgcaaagg atttagtaaa tcagacttct ccttaacctc
     7621 agtcaacaag tcctcatcca gtcccaattc ctgagcagcc tgaataaaat catgaaataa
     7681 ctgccaaatc agagattggt cataggtatt gccaatcgaa atcggcccat gttctgggga
     7741 ataagacgga gaagacaccc aacgctgcgc ctgctgatcc ttatgtaaaa aggcattcca
     7801 aaaacgaacc gtttccctca acatgggata aattttctcc ctgagatagt cttggtccct
     7861 ataaaatgaa taggcttcat aaacggtttg catcatccac gcgttggcag ctggtgacca
     7921 accccaatag taatcccaac caggtgccgt ccaaccaaag ggagtcgctt gagtatgaac
     7981 caaccaacca ttctcctcac ctttctgaga gacgattcct gcatacttta cagccgctag
     8041 acgaccatag acacgcaaat catctacata attgatgact ggaaagaccg tctctagaag
     8101 attggtaaca taggctggcc aataattcat ctgcagattg acatttaagt gatagtccga
     8161 attccaagga ggattgtcga ccgcattcca gactccctgt aggttagctg gtagagcatc
     8221 tgggcagtat ctggacgaac taatcaataa ataccgtcca tactggaaga acagctcctc
     8281 caaagcctgc ccttcttgtg gcttataatt ttttaacaaa tcatctgtag tggatgcgtc
     8341 aacatcagct tccaaatcca attgaacacg ctggaataag gcttggtagt cctcgatatg
     8401 ccttgatttc aattgggtat agcccttttc tttagctgtg tccaccaagt ctatcacctg
     8461 ttgctctaaa tctagtttct tgcgataatt gctagcagga ttttgggcaa aatccgtctt
     8521 agcggccaag aagagattgg cataactggc tcctgatatc tgaaccctat ctgaccaaac
     8581 tctaatatct ccatccgttt cccaagctag ataactagca aaccgcagat cattatcctt
     8641 aactcttccc ttcatcaaga tatgagaatc agtaatatcc aacttacact ccttgtaatc
     8701 agatttttcc tgctcatact ttccattaga agccaaatca caggtcaagg atagttctat
     8761 agtaaaatct agagtttcca acccttcctt agtaaaacat tgaaccaaga gatcatctgg
     8821 aaaactcgca aaagcttcac gttcaaatcg cgttccctta tagacataag aagtcgtcgc
     8881 aagtgcctta ctaatattca actgtctctg atagtccgtc acctgagaca aagtcgtacc
     8941 ttgctggctg aactcaatgt gaatatcccc aaaagacaga taggtcccat attgactcgt
     9001 ttttggccca attaggtgct gctcagccag ttccttagcc agattgtaat ctctcttctc
     9061 caaagcctgc cgaatctcag ctaaaaaaac atactgatcc tgaagatttc caccctgata
     9121 atctgaacta tcaggaagtg gacctccaga ccagagactt ttttcattaa attgaatccg
     9181 ttcagcccct ataaggccaa atacttttgc tcctaaagaa ccattgccta tcggtaaagc
     9241 ttcttcctcc caacccatgt aagtggttga agctggttgc ttgtaggcca gtacataatc
     9301 ttgtttttta ttccttatca tacttccata ctaacataaa aagcctagaa atcaattcta
     9361 gacttacaat tttttatttt ccaaggtagt attcagaaac gacgttcaat ttttcgtcga
     9421 attcgaatac caatggtggg aagttaggga tttccacgtc catgatctcg tcatctgaca
     9481 aacctttgat gtgttttaca agggcacgga ttgagttacc gtgagctcct acgaatacgt
     9541 ttttaccatc tttaagagct ggagcgattt tatcttccca gaatggaaga gcacgttcca
     9601 aagtcacttt caagttttca gcatctggga taactgagtc gtcaagtgaa gcgtaacgac
     9661 ggtctgtgtg agctgagtgc tcatcatcac ggtccatgtt tggaggcaat acatcgtatg
     9721 aacgacgcca gatgtgaact tgctcatcac caaattgttc agcagcttca gctttgtttt
     9781 taccagtcaa accaccgtag tgacgttcgt tcaagcgcca tgatttttca actggaaccc
     9841 acaattggtc agaagcttcg agagccaagt tagttgtttt gatagcacgt ttcaatactg
     9901 aagtgtaagc ttggtcaaat tcgataccag cttctttgat caatttacca gcgtcaatcg
     9961 cttgttgtgt acctttttca gacaaatcaa catcagccca accagtgaaa aggttagctt
    10021 tgttccattc agactcaccg tggcgagcaa aaaccaattt taccattaga tggattctcc
    10081 tttaaatttt ccgaggtttc ccctcgttta tctattctat tttacacaat ttttcacaaa
    10141 aaagctagtc aaaaccaaaa aggaaaggac tgtttgacaa tgtttggcaa tcacattgtt
    10201 tttggttgtt tctattctat cttcatttat ttaacctttt tttctgcgca tcgaataatt
    10261 tttgagttga ctcttttagt ttagtaaacg agtcattatt ttccatagct gtgcctttga
    10321 aaccttcctc agctttagta aaataatcat caaaaatatt tttataaaga tctatataat
    10381 ctgcataagt gcgtattgat tcaatcgcat cgtctgttac aaccggtgta tcgaaagtga
    10441 ttgtttcttt tgaactattg gatgttgcta ctgtcttctc atcattactt gttgaagtat
    10501 tctttgaact ttatgttcca catgcaacta gaagagaaag agataataga gctactccta
    10561 taccgataaa cttttttgtt cttttcatgc taaaatacct tttattcttc tgatttgaat
    10621 ttcttcaatg ttgcaaggaa tagagatcct ccgataatag caagaatccc cccaacccat
    10681 cctaagaatg gaatgagact aacttcacca gaaacaatca ttagtacaga cggagctgca
    10741 cctacatgct tatctccttt atagtaaaca atagcaatga taccaagaac aagatttgca
    10801 atcttcaagg tattcaagag taaggcaaca cctgaaaaag cccctgcagt agctcctcca
    10861 ttaagagttg tagcagctgt atttaccgct gttcccaaca agacaaaagg acaaataaga
    10921 agtaaaattc ctcccacaag accgacgata cc
//
LOCUS       DAVLHC010000055        10828 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.056, whole genome shotgun sequence.
ACCESSION   DAVLHC010000055 DAVLHC010000000
VERSION     DAVLHC010000055.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10828)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10828)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10828
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.056"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            11..874
                     /locus_tag="VXE25_001782"
                     /pseudo
     CDS             11..874
                     /locus_tag="VXE25_001782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093609.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
     gene            1257..1877
                     /locus_tag="VXE25_001783"
     CDS             1257..1877
                     /locus_tag="VXE25_001783"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000839915.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772203.1"
                     /translation="MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFV
                     SGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLLINLLGAVLVLSDNLFIKNTLQQ
                     ELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
                     VSLLIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF"
     gene            1963..2406
                     /gene="tsaE"
                     /locus_tag="VXE25_001784"
     CDS             1963..2406
                     /gene="tsaE"
                     /locus_tag="VXE25_001784"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     ATPase subunit type 1 TsaE"
                     /protein_id="HEV0772204.1"
                     /translation="MYTKNEEELQALGERLGHLLAKNDVLILTGELGAGKTTFTKGLA
                     KGLQISQMIKSPTYTIVREYEGRLPLYHLDVYRIEGDADSIDLDEFIFGGGVTVIEWG
                     NLLGDALPDAYLELEILKEADGRRLNFQAKGLRAEKLLEELQYGV"
     gene            2396..2914
                     /locus_tag="VXE25_001785"
     CDS             2396..2914
                     /locus_tag="VXE25_001785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0772205.1"
                     /translation="MEYELLIREAEPKDAAELVAFLNRVSLETDFTSLDGDGILLTSE
                     EMEIFLNKQASSDNQITLLAFLNGKIAGIVNITADQRKRVCHIGDLFIVIGKRYWNNG
                     LGSLLLEEAIEWAQASGILRRLQLTVQTRNQAAVHLYQKHGFVIEGSQERGAYIEEGK
                     FIDVYLMGKLID"
     gene            2922..3938
                     /locus_tag="VXE25_001786"
     CDS             2922..3938
                     /locus_tag="VXE25_001786"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000239264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LCP family protein"
                     /protein_id="HEV0772206.1"
                     /translation="MVKKIIGMVLALLSVTVVGVGVFAYTIYQQGTETLAKTYKKIGE
                     ETKVIEATEPLTILLMGVDTGNAERTETWVGRSDSMILMTVNPKTKKTTMMSLERDIL
                     TRIESGNGQAHEAKLNSAYADGGAELAIETIQKMMNIHIDRYVMVNMRGLQKLVDAVG
                     GITVNNILGFPISISDQEEFNTISIGVGEQHIGGEEALVYARMRYQDPEGDYGRQKRQ
                     REVIQKVMEKALSLNSVGHYQEILKALSDNMQTNIDLSAKSIPNLLGYKDSFKTIETQ
                     QLQGEGEILQGVSYQIVSRAHMLEMQNILRRSLGQEEVTQLETNAVLFEDLFGRAPVG
                     DEDN"
     gene            4023..5279
                     /locus_tag="VXE25_001787"
     CDS             4023..5279
                     /locus_tag="VXE25_001787"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000642700.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence/damage-inducible protein A"
                     /protein_id="HEV0772207.1"
                     /translation="MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGD
                     NEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQTLAKFLGKALVFDPQAQEKLDIF
                     FALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
                     VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLR
                     LSTKASSQEEANQALDILENQILDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQG
                     KTIAAAESLTAGLFQATVANFSGASSIFKGGFVTYSLEEKSRMLDIPAKNLEEHGVVS
                     EFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQEQGTEVIKVNIG
                     GRSRADVRHIAVMHAFNLVRKALLSD"
     gene            5334..6500
                     /gene="recA"
                     /locus_tag="VXE25_001788"
     CDS             5334..6500
                     /gene="recA"
                     /locus_tag="VXE25_001788"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397020.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase RecA"
                     /protein_id="HEV0772208.1"
                     /translation="MAKKPKKLEEISKKFGAEREKALNDALKLIEKDFGKGSIMRLGE
                     RAEQKVQVMSSGSLALDIALGSGGYPKGRIIEIYGPESSGKTTVALHAVAQAQKEGGI
                     AAFIDAEHALDPAYAAALGVNIDELLLSQPDSGEQGLEIAGKLIDSGAVDLVVVDSVA
                     ALVPRAEIDGDIGDSHVGLQARMMSQAMRKLGASINKTKTIAIFINQLREKVGVMFGN
                     PETTPGGRALKFYASVRLDVRGNTQIKGTGDQKETNVGKETKIKVVKNKVAPPFKEAV
                     VEIMYGEGISKTGELLKIASDLDIIKKAGAWYSYKDEKIGQGSENAKKYLAEHPEIFD
                     EIDKQVRSKFGLIDGEEVSEQDTENKKDEPKKEEAVNEEVTLDLGDELEIEIEE"
     gene            6807..8177
                     /locus_tag="VXE25_001789"
     CDS             6807..8177
                     /locus_tag="VXE25_001789"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HEV0772209.1"
                     /translation="MNKKRTVDLIHGPILPSLLSFTFPILLSNIFQQLYNTADVLIVG
                     RFLGQESLAAVGATTAIFDLIVGFTLGVGNGMGIVIARYYGARNFTKIKEAVAATWIL
                     GALLSILVMLLGFLGLYPLLQYLDTPAEILPQSYQYISMIVTCVGVSFAYNLFAGLLR
                     SIGDSLAALGFLIFSALVNVVLDLYFITQLHLGVQSAGLATIISQGLSAVLCFYYIRK
                     SVPELLPQFKHFKWDKSLYADLLEQGLAMGLMSSIVSIGSVILQSSVNTFGAVIISAQ
                     TAARRIMTFALLPMTAISASMTTFASQNLGAKQPDRIVQGLRIGSRLSISWAVFVCIF
                     LFFASPALVSFLASSTDGYLIENGSLYLQISSAFYPILSLLLIYRNCLQGLGQKILPL
                     VSSFIELIGKIVFVVLIIPWAGYKGVILCEPLIWVAMTVQLYFSLFRHPLIKEGKAIL
                     ATKVQS"
     gene            8553..9509
                     /gene="lytA"
                     /locus_tag="VXE25_001790"
     CDS             8553..9509
                     /gene="lytA"
                     /locus_tag="VXE25_001790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase LytA"
                     /protein_id="HEV0772210.1"
                     /translation="MEINVSKLRTDLPQVGVQPYRQVHAHSTGNPHSTVQNEADYHWR
                     KDPELGFFSHIVGNGCIMQVGPVDNGAWDVGGGWNAETYAAVELIESHSTKEEFMTDY
                     RLYIELLRNLADEAGLPKTLDTGSLAGIKTHEYCTNNQPNNHSDHVDPYPYLAKWGIS
                     REQFKHDIENGLTIETGWQKNDTGYWYVHSDGSYPKDKFEKINGTWYYFDSSGYMLAD
                     RWRKHTDGNWYWFDNSGEMATGWKKIADKWYYFNEEGAMKTGWVKYKDTWYYLDAKEG
                     AMVSNAFIQSADGTGWYYLKPDGTLADKPEFTVEPDGLITVK"
     gene            complement(10142..10828)
                     /locus_tag="VXE25_001791"
                     /pseudo
     CDS             complement(10142..10828)
                     /locus_tag="VXE25_001791"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=3
                     /transl_table=11
                     /product="IS5 family transposase"
BASE COUNT         3270 a         1878 c         2378 g         3302 t
ORIGIN      
        1 attatcttta atgagtacac tcgcagagaa attcagattg aaaagaaaag agttgagact
       61 ctcccaacaa actcttgcag aaggaatttg tgaacaaagc cagattagta aaattgagag
      121 agggcatttc attccctccg cagacctttt gttcaaactc tctcaacgac ttgaagtacc
      181 attagattat ttttttaatg aacaaattga aattaaatct aacctctcta atttcaagca
      241 attgtctgct cgactattag acgatagaaa ttatgacgat ttggaatata tttatagaat
      301 agagattgaa cgaagtactt ttctaacact agaagaccga acttaccttg aatggattaa
      361 agctattatt gacttctatc aatatgacag taagtgtgag gcaatttctt cattggaaaa
      421 tatattatta aaagtctctt caaatactct gatttattta aaggcgttga atactctatc
      481 taatttctat tccttagtgg gtcgtgaaca agaatatgag gcaaactact ctcatttaat
      541 agagttgtat cagacaaaaa atttggacca tcaagagttt ttatttggct acatcagagt
      601 tcgttacaac tacgctcact acctagtatc aaaggaaaaa tataatgaag ccatctaaga
      661 agctcttgaa acgattgaac tctgtaaaca aagatagaca agctaccaat tggctcctct
      721 acttattctt gtaggaaatg ctggagccaa atttctagac agagaacaag tcaaaaatta
      781 ttatatagaa gcaagagagc tatgcaagat ttataacaat cctttaatgc tgatgaagat
      841 agaaaattat ttgaaggaac tagatgctgt ttagtttatc ttgatattgg agtgttactt
      901 aaacattaaa tagcctgtaa ggctgatagt tagattaata ctatcagcct tataattatg
      961 tgactctgag tccgtctcgc tccgtgaggt gcgagacaaa acaaccaccc gtttgacgga
     1021 ttttcatgat ttcaaattta tattcttcga aaatctcttc aaaccacgtc agctctatct
     1081 gcaatctcaa aacagtgttt tgagcaacct gtggctagct acctagtttg atctttgatt
     1141 ttcattgagt attagtctct agtgtttgtt tagcgtctta aagagacatt tgagaagatt
     1201 agaaacagtt ctctcttttc tcctagtata atgattggta ggaagggaga gagaagatga
     1261 aatcaatgag aatcttattt ttgttagctt taattcaaat cagtttgagt agctgtttcc
     1321 tatggaagga atgcatcttg tcctttaaac aaagtacagc ttttttcatc ggaagcatgg
     1381 ttttcgtttc aggaatctgt gctggagtaa attatcttta tacccgtaag caagaagtcc
     1441 atagtgtcct agccagtaag aagtcggtga agctttttta cagtatgtta ctcttaatta
     1501 atttgttagg agctgttctt gttttgtcag ataacttgtt catcaaaaat acgctgcagc
     1561 aagaattagt tgacttttta ttgccatcct tctttttcct atttgggcta gatttgctga
     1621 tttttttacc cttgaaaaaa tacgtgcgcg attttcttgc tatgctagac agaaaaaaga
     1681 cagtgttggt gactatttta gcaacacttc ttttcttaag aaatccaatg accattgtct
     1741 cacttctgat ttatattgga ttgggcttgt tttttgcagc ctatcttgtc ccaaattcgg
     1801 ttaagaagga agtttccttt tatggtcata ttttccgaga tcttgtattg gtcattgtta
     1861 cgctcatttt cttttagaga aagcctgttt tttatggatg ttatgatgat aagtttagta
     1921 ggaaaataga cacaaaagaa aagtttttgg tataataaga gtatgtacac aaaaaatgaa
     1981 gaagagttgc aagccttagg ggagcgtttg ggccatctat tagcaaagaa tgatgtttta
     2041 atcttaactg gagaactggg tgcaggtaaa acgaccttta ctaaaggact tgcaaaagga
     2101 ttacagattt ctcaaatgat taaaagtcct acctatacta tcgtgagaga gtatgaaggt
     2161 cgacttccac tttatcacct agatgtttat cgtattgaag gagatgctga ttctatcgac
     2221 ttggatgagt ttatctttgg tggcggcgtg actgttattg agtggggaaa tctcttagga
     2281 gatgccttgc cagatgctta tttagaattg gaaattctaa aagaagcaga tggacgccgt
     2341 ttaaattttc aggcaaaggg tttgcgtgct gagaaattgt tagaggagct tcaatatgga
     2401 gtatgaattg ctcattaggg aagcagagcc caaagatgca gctgaattag tggccttttt
     2461 aaatcgtgtg agtttggaga cagactttac cagcctagac ggagatggta ttctcttgac
     2521 tagtgaggag atggaaatat tcctcaacaa gcaagctagt tcggacaatc agataacctt
     2581 acttgcattc ttaaatggca aaattgctgg tattgtaaat attacagctg accagcgtaa
     2641 gagagtctgt catattggag atctcttcat tgtgattgga aaaagatatt ggaataatgg
     2701 cttgggaagt ttgttgctag aagaagcgat agagtgggca caagcaagtg gcattctgcg
     2761 tcgtctccaa ctgactgtcc aaactcgtaa tcaagcagca gtccatcttt atcaaaagca
     2821 tggctttgtc attgaaggta gccaagagcg tggggcatat atagaagaag ggaaatttat
     2881 cgatgtttac ttgatgggta aactgataga ttagtagaaa tatggttaaa aaaattattg
     2941 gaatggtgct agctttactt tctgtaactg tagtaggagt aggtgttttt gcttatacta
     3001 tttatcaaca agggacagaa accttagcta aaacctataa aaaaatcggc gaagaaacca
     3061 aggttattga agcgactgaa cctctaacca ttctgttaat gggagtggac accggaaatg
     3121 ctgaacgaac tgaaacttgg gtcggtagaa gtgatagcat gatcttgatg acagtgaatc
     3181 ctaaaacgaa aaaaacaaca atgatgagtt tagagcggga tattctgacg cgcattgaat
     3241 cagggaatgg tcaggctcat gaagcgaaac tgaactcagc atatgcagat ggtggagcag
     3301 agcttgctat agaaaccatt caaaaaatga tgaatatcca tattgatcgc tatgtgatgg
     3361 tcaatatgag agggttgcaa aaactagtgg atgcagtagg aggtattaca gtcaataata
     3421 tcctaggttt cccaatttct atcagtgacc aagaagaatt taatactatt tctatcggtg
     3481 ttggggagca acatattggg ggagaagaag ccctagtcta tgcacgaatg cgttaccaag
     3541 atcctgaggg ggattatggt cgtcaaaaac gtcaacgtga agttattcaa aaagtcatgg
     3601 aaaaagctct cagtttaaat agcgttggtc attatcaaga gattctaaaa gctttgagtg
     3661 acaatatgca gaccaatatt gatttgtctg caaaaagtat ccctaacttg ctaggctata
     3721 aagattcatt taaaaccatt gaaactcagc agttgcaggg tgaaggagag atacttcaag
     3781 gtgtttctta ccagattgtt tcgagagcac atatgttgga aatgcaaaat atactccgac
     3841 gttctttggg acaagaagaa gttactcagc ttgaaaccaa tgcggtttta tttgaagatt
     3901 tatttggcag agcacctgtt ggtgatgaag ataattaact tttgatacaa ataaaaaaat
     3961 caatcgtagg aaaattcctg cgattttttc aaaaaaatac gaatagatag gtaggaggaa
     4021 acatgaaagc agaaatcatt gctgttggaa cagagatttt gacaggacag attgtcaaca
     4081 ccaatgccca gtttttgtcg gaaaaactag ctgagattgg ggtagatgta tattttcaga
     4141 cggctgtagg agacaatgaa gttcgtctct tgtctttgct tgagattgcc agtcaacgta
     4201 gcagtctggt gattttgaca ggcggtttgg ggccaactga ggacgaccta accaaacaaa
     4261 ccctagctaa atttttaggg aaagcattag tctttgatcc tcaggctcag gagaagttgg
     4321 atatcttttt tgccctgcga ccagactatg cccgaacacc gaataacgaa agacaagctc
     4381 aaattgtaga aggagcgatt ccactgccaa acgaaacagg actggctgtt ggaggaaaat
     4441 tagaagtaga cggagtgacc tatgtcgtcc ttccaggtcc gccaagtgaa ttgaaaccca
     4501 tggtcttaaa ccaacttcta cccaagttga tgacagggag caagctgtat tcccgagttc
     4561 ttcgtttctt tgggattggc gagagccagt tggttacgat tttggctgat ttaattgata
     4621 atcagatcga tcctaccttg gccccttatg ccaagacagg agaagtcact ctacgtctgt
     4681 caacaaaggc tagcagtcaa gaagaggcga atcaagcgct ggatatcttg gaaaatcaaa
     4741 tcttggactg ccagactttc gaaggaattt ctttacgaga cttttgctat ggttatgggg
     4801 aagaaactag tttagccagc attgtggtag aagaactgaa aaggcaaggg aaaaccatcg
     4861 cggctgcaga gagtttaacg gcaggtcttt tccaagctac cgtggcgaat ttttctggag
     4921 cttcaagtat atttaagggt ggttttgtga cctatagctt ggaggaaaaa tcaaggatgt
     4981 tggatattcc tgccaagaat ttggaagaac atggtgtggt gtctgaattt acagctcaga
     5041 agatggctga gcaggcacga agcaagaccc agtctgattt tggaattagt ttgaccggag
     5101 tggcaggacc agatagccta gaaggacacc cagttgggac agtcttcata ggcttggcgc
     5161 aagagcaagg aactgaggtt atcaaggtta atattggagg cagaagccga gcagatgtac
     5221 gtcatattgc ggttatgcat gcctttaacc tagttcgcaa ggctttatta agtgactaac
     5281 ttttgatata atagtagata ggtctgagga tcattagaat gtaggagaat agaatggcga
     5341 aaaaaccaaa aaaattagaa gaaatttcaa aaaaatttgg ggcagaacgt gaaaaggcct
     5401 tgaatgatgc tcttaaattg attgagaaag actttggtaa aggatcaatc atgcgtttgg
     5461 gtgaacgtgc ggagcaaaag gtgcaagtga tgagctcagg ttctttagct cttgacattg
     5521 cccttggctc aggtggttat cctaagggac gtatcatcga aatctatggc ccagagtcat
     5581 ctggtaagac aacggttgcc cttcatgcag ttgcacaagc gcaaaaagaa ggtgggattg
     5641 ctgcctttat cgatgcggaa catgcccttg atccagctta tgctgcggcc cttggtgtca
     5701 atattgacga attactcttg tctcaaccag actcaggaga gcaaggtctt gagattgcgg
     5761 gaaaattgat tgactcaggt gcagttgatc ttgtcgtagt cgactcagtt gctgcccttg
     5821 ttcctcgtgc ggaaattgat ggagatatcg gagatagcca tgttggtttg caggctcgta
     5881 tgatgagcca ggccatgcgt aaacttggcg cctctatcaa taaaaccaaa acaattgcca
     5941 tttttatcaa ccaattgcgt gaaaaagttg gagtgatgtt tggaaatcca gaaacaacac
     6001 cgggcggacg tgctttgaaa ttctatgctt cagtccgctt ggatgttcgt ggtaatacac
     6061 aaattaaggg aactggtgac caaaaagaaa ccaatgtcgg taaagaaact aagattaagg
     6121 ttgtaaaaaa taaggtagct ccaccgttta aggaagccgt agttgaaatt atgtacggag
     6181 aaggaatttc taagactggt gagcttttga agattgcaag cgatttggat attatcaaaa
     6241 aagcaggggc ttggtattct tacaaagatg aaaaaattgg gcaaggttct gagaatgcta
     6301 agaaatactt ggcagagcac ccagaaatct ttgatgaaat tgataagcaa gtccgttcta
     6361 aatttggctt gattgatgga gaagaagttt cagaacaaga tactgaaaac aaaaaagatg
     6421 agccaaagaa agaagaagca gtgaatgaag aagttacgct tgacttaggc gatgaacttg
     6481 aaatcgaaat tgaagaataa gctgttaaag cagtggagaa atccgctact ttttcgattt
     6541 ttgattcaag tttttagatt atatatagta gcttgaaata agatatgaac aactctatta
     6601 ggaaagtcaa attaatttct agaaatgttt tagcagctac agcgtactat tccaaactca
     6661 accaactata atagatcgaa actagaatag tacatatcta cttctaaaac attgttaaaa
     6721 atcgatttga ctttccttat ttcattccgc tatatataag tttgctgttt cttgtcgctc
     6781 ctctggaaag ctgatataat agctttatga ataaaaaacg aacagtggac ctgatacatg
     6841 gtccgattct tccctcgctc ttaagcttca cctttccaat tttgctatca aatatttttc
     6901 aacagctcta taacactgct gatgtcttga ttgttggacg atttcttggt caagaatcct
     6961 tggctgcagt aggagcgacg acagcgattt ttgacctgat tgtaggtttt acacttggtg
     7021 ttggcaatgg catggggatt gtcattgctc gttattatgg ggctcggaat ttcactaaaa
     7081 tcaaggaagc agtagcagct acttggattt taggtgctct tttgagcatt ctagttatgt
     7141 tgctgggctt tcttggcttg tatcctctct tgcaatactt agatactcct gcagaaattc
     7201 ttcctcaatc ttatcaatat atttctatga ttgtgacctg tgtaggtgtc agctttgctt
     7261 ataatctttt tgcaggcttg ttgcggtcta ttggtgacag tctagcagcc ctgggatttc
     7321 tgattttctc tgccttggtt aatgtggttc tggatctcta ttttattacg caattgcatc
     7381 tgggagttca atccgcagga cttgctacca ttatttcgca aggtttatca gcggttctct
     7441 gcttttatta tattcgtaaa agtgtgccag aactcttgcc acagtttaaa catttcaaat
     7501 gggacaaaag cttgtacgca gatctcttgg agcaaggttt ggctatgggc ttgatgagtt
     7561 caattgtatc tatcggcagt gtgattttac agtcttctgt taatacattt ggtgcagtga
     7621 ttattagtgc ccagacggca gctcgacgca ttatgacctt tgcccttctt cctatgaccg
     7681 ctatttctgc atcaatgacg acctttgctt ctcagaatct aggagctaag caacctgacc
     7741 gcattgttca aggtcttcga atcggcagtc gtttaagtat atcctgggca gtttttgttt
     7801 gtattttcct cttttttgcc agtccagcct tggtttcctt cttggctagt tcgacagatg
     7861 gttacttgat agaaaatgga agtctctatc tgcaaatcag ttcagccttt tatcccattt
     7921 tgagcctctt gttgatttat cgcaattgct tgcagggctt ggggcagaag atccttcctc
     7981 tagtttctag ctttattgaa ctaatcggaa aaatcgtttt tgtggttttg attattcctt
     8041 gggcaggata taagggtgtt atcctttgtg aacctcttat ctgggttgcc atgacagttc
     8101 aactgtactt ctcactattc cgtcatccct tgataaaaga aggaaaggca attttggcaa
     8161 ccaaagtgca atcctagttg gatttactga ataaaatcca tttcctctag tgaaaatcga
     8221 aaaaacttgt gttctcttct ttagtttggt gttgaaaata gtttaacaga cttttgactt
     8281 cttttatatg atataataaa gtatagtatt tatgaaaagg acatatagag actgtaaaaa
     8341 tatacttttg aaaagctttt tagtttgggg tgttattgta gatagaatgc agaccttgtc
     8401 agtcctattt acagtgtcaa aatagtgcgt tttgaagttc tatctacaag cctaatcgtg
     8461 actaaaattg tcttctttgt aaggtagaaa taaaggagtt tctggttctg gattgtaaaa
     8521 aatgagttgt tttaattgat aaggagtaga atatggaaat taatgtgagt aaattaagaa
     8581 cagatttgcc tcaagtcggc gtgcaaccat ataggcaagt acacgcacac tcaactggga
     8641 atccgcattc aaccgtacag aatgaagcgg attatcactg gcggaaagac ccagaattag
     8701 gttttttctc gcacattgtt gggaacggtt gcatcatgca ggtaggacct gttgataatg
     8761 gtgcctggga cgttgggggc ggttggaatg ctgagaccta tgcagcggtt gaactgattg
     8821 aaagccattc aactaaagaa gagttcatga cggactaccg cctttatatc gaactcttac
     8881 gcaatctagc agatgaagca ggtttgccga aaacgcttga tacagggagt ttagctggaa
     8941 ttaaaacgca cgagtattgc acgaataacc aaccaaacaa ccactcagac catgtggatc
     9001 cataccctta cttggcaaaa tggggcatta gccgtgagca gtttaagcat gatattgaga
     9061 acggcttgac gattgaaaca ggctggcaga agaatgacac tggctactgg tacgtacact
     9121 cagacggctc ttatccaaaa gacaagtttg agaaaatcaa tggcacttgg tactactttg
     9181 acagttcagg ctatatgctt gcagaccgct ggaggaagca cacagacggc aactggtact
     9241 ggttcgacaa ctcaggcgaa atggctacag gctggaagaa aatcgctgat aagtggtact
     9301 atttcaacga agaaggtgcc atgaagacag gctgggtcaa gtacaaggac acttggtact
     9361 acttagacgc taaagaaggc gccatggtat caaatgcctt tatccagtca gcggacggaa
     9421 caggctggta ctacctcaaa ccagacggaa cactggcaga caagccagaa ttcacagtag
     9481 agccagatgg cttgattaca gtaaaataat aatggaatgt ctttcaaatc agaacagcgc
     9541 atattattag gtcttgaaaa agcttaatag tatgcgtttt tatcctctag tcacttgatt
     9601 tgtttcaggt ggttttttag tatagtagaa tgaaacgaga acaggacaaa ttgatcagga
     9661 cagtcaaatc gatttctaac aatgttttag aagcagaagt gtactattct agtttcaatc
     9721 tactatagtt aaatctgcgg tcaagtctac tggtgaatct atgattgtaa tactcttcca
     9781 aaatctcatc aaccacgtca gtcttgcctt gcagtctgta tcttactgac caagctagtg
     9841 atggatttag aataggtgat ttggagcgtc ctattggcta ggaaatgctg ctcatagtcc
     9901 tttgctgagg ctagggtgtt tcaacattca acactcaact ggttgatcta gttgatagga
     9961 agggaattac tataaaatac tcaggcttcc atcatatttt ttgaaacgat tgtgtaatca
    10021 aaatgtacca atattgtagt attggtacag aagatgttgt gaatggataa atatatcata
    10081 actgctgtct caaaaagatt tcatatgtct gtgcatatat aatagacttc ctgcgaaacc
    10141 aaaatcctag ttcatgattg ataataccag cactcaaatt cattcgtaat ccgaagcgtt
    10201 tacgatgatt tcgataggtt gttgaaatca ttttaaacgt ttttactttg gcaaagatgt
    10261 tctcaacctt gcttctctcc ttggatagcg catggttaca ggctttatct tcaactgtta
    10321 gtggcttgag tttgctggat ttacgtggag tttgtgcttg aggatatatc ttcatgagcc
    10381 cttgataacc actgtcagcc aagattttac cagcttgtcc gatatttccg cgactcattt
    10441 tgaacaactt catatcatga caatagttca cagtgatatc caaagaaata attcttcctt
    10501 gacttgtgac aatcgcttga gccttcatag cgtagcattt ctttttacca gaatcattcg
    10561 ctaattgttt ttttagggcg attgatttgt acttccgtcg catcaatcat taccgtgtcc
    10621 tcagaactga gaggagttct tgaaatcgta acaccacttt gaacaagagt tacttcaacc
    10681 cattggctcc gacggattaa gttgctttcg tgaataccaa aatcagccgc aatttgttca
    10741 taagtgcggt attctcgcac atattgaaga gtggccataa gaaggtcttc taggcttaat
    10801 ttaggttttc gtccaccttt tgcgtgtt
//
LOCUS       DAVLHC010000056        10818 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.057, whole genome shotgun sequence.
ACCESSION   DAVLHC010000056 DAVLHC010000000
VERSION     DAVLHC010000056.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10818)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10818)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10818
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.057"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            127..624
                     /locus_tag="VXE25_001792"
     CDS             127..624
                     /locus_tag="VXE25_001792"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000920162.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GAF domain-containing protein"
                     /protein_id="HEV0772211.1"
                     /translation="MLKSEKQSRYQMLNEELSFLLEGETNVLANLSNASALIKSRFPN
                     TVFAGFYLFDGKELVLGPFQGGVSCIRIALGKGVCGEAAHFQETVIVGDVTTYLNYIS
                     CDSLAKSEIVVPMMKNGQLLGVLDLDSSEIEDYDAMDRDYLEQFVAILLEKTTWDFTM
                     FEEKS"
     gene            624..2279
                     /gene="dnaX"
                     /locus_tag="VXE25_001793"
     CDS             624..2279
                     /gene="dnaX"
                     /locus_tag="VXE25_001793"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000283769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit gamma/tau"
                     /protein_id="HEV0772212.1"
                     /translation="MYQALYRKYRSQNFSQLVGQEVVAKTLKQAVEQEKISHAYLFSG
                     PRGTGKTSVAKIFAKAMNCPNQVGGEPCNNCYICQAVTDGSLEDVIEMDAASNNGVDE
                     IREIRDKSTYTPSLARYKVYIIDEVHMLSTGAFNALLKTLEEPTQNVVFILATTELHK
                     IPATILSRVQRFEFKSIKTQDIKEHIHYILEKENISSEPEAVEIIARRAEGGMRDALS
                     ILDQALSLTQGNELTTAISEEITGTISLSALDDYVAALSQQDVPKALSCLNLLFDNGK
                     SMTRFVTDLLHYLRDLLIVQTGGENTHHSSVFVENLALPQKNLFEMIRLATVSLADIK
                     SSLQPKIYAEMMTVRLAEIKSEPALSGAVENEIATLRQEVARLKQELSNVGAVPKQVA
                     PAPSRPATGKTVYRVDRNKVQSILQEAVENPDLARQNLIRLQNAWGEVIESLGGPDKA
                     LLVGSQPVAANEHHAILAFESNFNAGQTMKRDNLNTMFGNILSQAAGFSPEILAISME
                     EWKEVRAAFSAKAKSSQIEKEVEESLIPEGFEFLADKVKVEED"
     gene            2307..2501
                     /locus_tag="VXE25_001794"
     CDS             2307..2501
                     /locus_tag="VXE25_001794"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001041548.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3272 domain-containing protein"
                     /protein_id="HEV0772213.1"
                     /translation="MNKQQFIIMALFTAAETYFFNEAWMTGRYIMAAFWAILLFRNFR
                     VSYVMGKIVDVIDQHFNRKD"
     gene            2651..3421
                     /gene="sufC"
                     /locus_tag="VXE25_001795"
     CDS             2651..3421
                     /gene="sufC"
                     /locus_tag="VXE25_001795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000114488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly ATPase SufC"
                     /protein_id="HEV0772214.1"
                     /translation="MSVLEIKDLYVEIEGKEILKGVNLTLKTGEIAAIMGPNGTGKST
                     LSAAIMGNPNYEVTKGEVLFDGVNILELEVDERARMGLFLAMQYPSEIPGITNAEFLR
                     AAMNAGKEDDEKISVREFITKLDEKMELLNMKEEMAERYLNEGFSGGEKKRNEILQLL
                     MLEPTFALLDEIDSGLDIDALKVVSKGVNAMRGEGFGAMIITHYQRLLNYITPDVVHV
                     MMEGRVVLSGGPELAARLEREGYAKLAEELGYDYKEEL"
     gene            3449..4711
                     /gene="sufD"
                     /locus_tag="VXE25_001796"
     CDS             3449..4711
                     /gene="sufD"
                     /locus_tag="VXE25_001796"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly protein SufD"
                     /protein_id="HEV0772215.1"
                     /translation="MTRENIKLFSEMHAEPSWLADLRQKAFDKIETLELPVIERVKFH
                     RWNLGDGTITENEPSANVPDFTALDHHLKLVQVGTQTVFEQTPVELAEQGVVFTDFHS
                     ALEEIPELIEEFFMSSVKYDDDKLAAYHTAYFNSGAVLYIPDNVEITEPIEGIFYQDS
                     DSNVPFNKHIMIIAGKNSKISYLERLESRGEGSDKATANITVEVIARSGAQVKFAAID
                     RLGENVTAYISRRGKLGNDASIDWAIGVMNEGNVVADFDSDLLGNGSHADLKVVALSS
                     GRQVQGIDTRVTNYGCNSIGNILQHGVILEKATLTFNGIGHIIKGAKGADAQQESRVL
                     MLSDQARSDANPILLIDENDVTAGHAASIGQVDPEDMYYLMSRGLDKATAERLVVRGF
                     LGSVIVEIPVKEVRDEMIATIEEKLSKR"
     gene            4722..5948
                     /locus_tag="VXE25_001797"
     CDS             4722..5948
                     /locus_tag="VXE25_001797"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000887707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase"
                     /protein_id="HEV0772216.1"
                     /translation="MLDVEAIRKDFPILDQIVNDEPLVYLDNAATTQKPLVVLKAINS
                     YYEQDNANVHRGVHTLAERATASYEAARETIRKFINACSTKEVLFTRGTTTSLNWVAR
                     FAEEILTEGDQVLISVMEHHSNIIPWQEACRKTGAELVYVYLKDGALDMEDLRAKLTD
                     KVKFVSLAHASNVLGVVNPIKEITQLAHQVGAIMVVDGAQSTPHMKIDVQDLDLDFFA
                     FSGHKMAGPTGIGVLYGKEKYLEQMSPVEFGGEMIDFVYEQSASWKELPWKFEAGTPN
                     MAGAIGLATAVDYLEKIGMDAVEAHEQELIAYVYPKLQAIEGLTIYGSQDLAQRSGVI
                     AFNLGDLHPHDLATALDYEGVAVRAGHHCAQPLLQYLEVPASARASFYIYNTKADCDK
                     LVDALQKTKEFFNGTF"
     gene            5935..6375
                     /locus_tag="VXE25_001798"
     CDS             5935..6375
                     /locus_tag="VXE25_001798"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397187.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SUF system NifU family Fe-S cluster assembly
                     protein"
                     /protein_id="HEV0772217.1"
                     /translation="MALSKLDSLYMAVVADHSKNPHHQGKLEDAEQISLNNPTCGDVI
                     NLSVKFDAEDRLEDIAFLNSGCTISTASASMMTDVVLGKTKQEILELATIFSEMVQGQ
                     KDERQGQLGDAAFLSGVAKFPQRIKCATLAWNALKKTIENQEKQ"
     gene            6429..7841
                     /gene="sufB"
                     /locus_tag="VXE25_001799"
     CDS             6429..7841
                     /gene="sufB"
                     /locus_tag="VXE25_001799"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly protein SufB"
                     /protein_id="HEV0772218.1"
                     /translation="MAEERVEPKPIDLGEYKFGFHDDVEPVLSTGKGLNEGVIRELSA
                     AKGEPEWMLEFRLKSYETFKKMPMQTWGADLSEIDFDDLIYYQKPSDKPARSWDDVPE
                     KIKETFERIGIPEAERAYLAGASAQYESEVVYHNMKEEFQKLGIIFTDTDSALKEYPD
                     LFKQYFAKLVPPTDNKLAALNSAVWSGGTFIYVPKGVKVDIPLQTYFRINNENIGQFE
                     RTLIIVDEGASVHYVEGCTAPTYSSNSLHAAIVEIFALDGAYMRYTTIQNWSDNVYNL
                     VTKRAKAQKDATVEWIDGNLGAKTTMKYPSVYLDGEGARGTMLSIAFANAGQHQDTGA
                     KMIHNAPHTSSSIVSKSIAKGGGKVDYRGQVTFNKNSKKSVSHIECDTIIMDDLSASD
                     TIPFNEIHNSQVALEHEAKVSKISEEQLYYLMSRGLSESEATEMIVMGFVEPFTKELP
                     MEYAVELNRLISYEMEGSVG"
     gene            complement(8072..9313)
                     /locus_tag="VXE25_001800"
     CDS             complement(8072..9313)
                     /locus_tag="VXE25_001800"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase"
                     /protein_id="HEV0772219.1"
                     /translation="MKKIFLTLLTVSLLGGASTAVAQDFTIAAKHAIAVEANTGKILY
                     EKDATQPVEIASITKLITVYLVYEALENGSITLSTPVDISDYPYQLTTNSEASNIPME
                     ARNYTVEELLEATLVSSANSAAIALAEKIAGSEKDFVDMMRAKLLEWGIQDATVVNTT
                     GLNNETLGDNIYPGSKKDEENKLSAYDVAIVARNLIKKYPQVLEITKKPSSTFAGMTI
                     TSTNYMLEGMPAYRGGFDGLKTGTTDKAGESFVGTTVEKGMRVITVVLNADHQDNNPY
                     ARFTATSSLMDYISSTFTLRKIVQQGDAYQDSKAPVQDGKEDTVTAVAPEDIYLIERV
                     GNQSSQSVQFTPDSKAIPAPLEAGTVVGHLTYEDKDLIGQGYITTERPSFEMVADKKI
                     EKAFFLKVWWNQFVRFVNEKL"
     gene            9416..10525
                     /locus_tag="VXE25_001801"
     CDS             9416..10525
                     /locus_tag="VXE25_001801"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000489839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HEV0772220.1"
                     /translation="MFRRNKLFFWTTEILLLTIIFYLWRQMGSLINPFVSVLNTIMIP
                     FLLGGFLYYLTNPIVTFLNKVCKLNRLLGILITLCTLIWGMVIGVVYLLPILINQLSS
                     LIISSQTIYSRVQDLIIDLSNYPALQNLDVEATIQQLNLSYVDILQNILNSVSNSVGS
                     VLSALISTVLILIMTPVFLVYFLLDGHKFLPMLERTILKRDRLHIAGLLKNLNATIAR
                     YISGVSIDAIIIGCLAYIGYSIIGLKYALVFAIFSGVANLIPYVGPSIGLIPMIIANI
                     FTDPHRLLIAVIYMLVVQQVDGNILYPRIVGSVMKVHPITILVLLLLSSNIYGVVGMI
                     VAVPTYSILKEISKFLSRLYENHKIMKERERELAK"
BASE COUNT         3213 a         1975 c         2342 g         3288 t
ORIGIN      
        1 taaaataggt tccataatat ctatagtgga tttacccact acaaatatta tagagcccaa
       61 aatcctttgt ttactaaaca agggattttt cttttgtctc tgctcctttt ttgatataat
      121 agttctatgt taaaatcaga aaaacaatca cgttatcaaa tgttaaatga agaattgtcc
      181 ttcctattgg aaggcgaaac caatgttttg gctaatcttt ccaacgccag tgctctcata
      241 aaatcacgtt ttcctaatac cgtatttgca ggcttttatt tgttcgatgg aaaggaattg
      301 gttttaggtc ccttccaagg aggtgtttcc tgcatccgta ttgcactagg caagggtgtt
      361 tgtggtgagg cagctcactt tcaggaaact gttattgttg gagatgtgac gacctatctc
      421 aactatattt cttgtgatag tctagctaaa agtgaaattg tggtgccgat gatgaagaat
      481 ggtcagttac ttggagttct ggatctggat tcttcagaga ttgaggatta cgatgctatg
      541 gatcgagatt atttggaaca atttgtcgct attttgcttg aaaagacaac atgggacttt
      601 acgatgtttg aggaaaaatc ttaatgtatc aagcacttta tcgaaaatat agaagtcaaa
      661 acttctccca gttagttggt caagaagttg tggctaagac tcttaaacaa gcggtggagc
      721 aagagaaaat aagtcacgct tatctttttt ctggtcctcg tggaacggga aaaaccagtg
      781 ttgctaaaat ctttgccaag gctatgaact gtcccaatca agtgggtggc gaaccttgca
      841 ataactgcta tatttgtcaa gcagtgacgg acggtagttt agaagatgtc attgaaatgg
      901 atgcagcttc taataatggg gtagatgaaa ttcgcgaaat tcgtgataaa tctacctata
      961 cgcctagcct tgctcgttat aaggtttata tcatagatga ggttcacatg ctgtctacag
     1021 gggcttttaa tgccctccta aagacgctgg aagaaccaac acagaatgta gtctttattt
     1081 tggccactac tgaattgcac aagattcctg ctactattct atcccgtgtg caacgttttg
     1141 agtttaaatc aattaagaca caggatatta aggaacatat tcactatatc ttagaaaaag
     1201 aaaatatcag ttctgaacca gaggctgtgg aaatcattgc cagacgggcg gaaggtggaa
     1261 tgcgggacgc cttgtctatt ttggatcaag ccctgagttt gacacaggga aatgagctga
     1321 cgactgctat ctctgaagaa attactggca ccattagcct atcagccttg gatgattatg
     1381 tggcggcctt gtctcaacag gatgttccca aagctttgtc ttgcttgaat cttctttttg
     1441 acaatggtaa gagcatgact cgttttgtga ccgatctttt gcactattta agagacttgt
     1501 taattgttca aacaggggga gaaaatactc atcatagttc agtctttgta gaaaatttgg
     1561 cacttcctca aaaaaatctg tttgaaatga ttcgcttagc aacagtgagt ttagcagata
     1621 ttaagtctag tttgcagccc aagatttatg ctgaaatgat gaccgtccgt ttggcggaaa
     1681 tcaagtccga accagcttta tcaggagcgg ttgaaaatga aattgctacg ctgagacagg
     1741 aagttgcccg tctcaaacaa gagctttcta atgtaggtgc ggttcctaaa caagttgcac
     1801 cagctcctag tcgaccagct acgggcaaaa cagtctatcg tgtcgatcgc aataaagtgc
     1861 aatctatctt acaagaggcc gtcgaaaatc ctgatttagc acgtcaaaat ttaattcgtt
     1921 tgcagaatgc ctggggagag gtaattgaaa gtctaggtgg gccggacaag gctctgctag
     1981 ttggttctca accggttgct gccaatgaac accatgctat tcttgctttt gagtctaact
     2041 tcaatgctgg tcaaactatg aaacgagaca atctcaatac catgtttggt aatatcctca
     2101 gtcaggcggc aggtttttca cctgagattt tagctatttc catggaggaa tggaaagaag
     2161 ttcgcgcagc cttttcagcc aaagccaaat cttctcaaat tgaaaaagaa gtagaagaaa
     2221 gcctgattcc agaaggattt gaatttttgg ctgataaagt gaaggtagag gaagactaaa
     2281 gaaagatttc atgatacaat aagtttatga ataaacaaca atttattatt atggcgctgt
     2341 ttacagctgc tgagacctat tttttcaatg aagcctggat gactggtcgc tatattatgg
     2401 cagccttttg ggcaatttta ctctttagaa atttccgagt cagttatgtg atgggcaaaa
     2461 tcgttgatgt catcgatcag cattttaata ggaaagacta gccctcagct tccagacaaa
     2521 atcaaagcct tttaggcttt tttttgttat actagaaaag tatatttata gaatttttgc
     2581 tctatttctg gggaaatcag acgtttttct agtaagtact gtaaaagttt tgaaaaagaa
     2641 aggaactatc atgtcagtat tagagatcaa agatctttac gttgagattg aaggaaaaga
     2701 aattttaaaa ggggttaacc tgaccctgaa aacaggagaa attgccgcta tcatgggacc
     2761 aaatggtaca ggtaaatcga ctctttctgc cgctatcatg ggaaatccaa actatgaagt
     2821 aactaaaggt gaagttttgt ttgatggcgt aaacatcctt gagttggaag tggatgagcg
     2881 tgcgcgtatg ggacttttcc ttgctatgca atacccatca gaaatccctg gaattaccaa
     2941 tgctgagttt cttcgtgccg ctatgaatgc gggtaaagaa gatgatgaga agatttcagt
     3001 tcgtgagttt attactaagc tagatgaaaa aatggaattg ctcaacatga aagaagaaat
     3061 ggcagagcgt tacctcaacg aaggcttctc tggtggtgag aaaaaacgca atgaaattct
     3121 tcaacttttg atgttggagc caacatttgc tcttttggac gagattgact caggtcttga
     3181 tattgacgct cttaaagttg tgtctaaagg tgtcaatgcc atgcgtggtg aaggttttgg
     3241 tgctatgatc atcactcact accaacgtct tttgaactat atcacacctg atgtggtaca
     3301 cgtgatgatg gaaggtcgtg ttgtcctttc tggtggtcca gaattggctg cgcgtttgga
     3361 acgtgaagga tacgcaaaac tagctgaaga acttggctac gactacaagg aagaattgta
     3421 attccctcgt atcttttagg agaagtaaat gactagagaa aatattaaac ttttttcaga
     3481 aatgcacgct gaaccaagct ggttggctga tctccgtcaa aaagcttttg acaagattga
     3541 gactttggaa ttaccagtta ttgagcgtgt caaattccac cgttggaatc tgggtgatgg
     3601 aacgattaca gaaaatgagc catcagcaaa tgttccagat ttcacagctt tagatcatca
     3661 cttgaagttg gtgcaagtag gaactcaaac tgttttcgaa caaactccag ttgagttagc
     3721 tgaacagggt gttgtcttca cagactttca ctcagcttta gaagaaattc cagagctgat
     3781 cgaagaattc ttcatgtcat ctgttaagta tgatgatgac aagttggcgg cttaccacac
     3841 agcttacttt aacagtggtg ctgtactcta tattccagat aacgtagaaa ttacagagcc
     3901 aattgaagga attttctacc aagatagcga tagcaatgtg ccgtttaaca agcatattat
     3961 gattatcgct ggtaaaaatt ctaagattag ttatctggag cgtttagagt cacgcggtga
     4021 aggaagtgac aaagcaactg ccaatatcac agtggaagtg attgcacgtt ctggtgcgca
     4081 agtcaagttt gctgctatcg accgtctagg tgaaaacgtc actgcctaca ttagccgtcg
     4141 tggtaaatta ggcaacgatg caagtattga ctgggctatc ggtgtcatga acgaaggaaa
     4201 tgtcgttgct gattttgata gtgacttgct tggaaatggt agccatgcgg acctcaaggt
     4261 agtagcactt tcaagtggtc gtcaggtgca agggattgat actcgcgtga ctaactatgg
     4321 ttgcaactct atcggaaata tcctacaaca tggggttatc cttgaaaaag caactttgac
     4381 tttcaatggt atcggccaca tcatcaaggg tgctaaggga gcagatgccc aacaagagag
     4441 ccgtgttctc atgctttcag accaagcgcg ttcagatgct aacccaattc ttttgattga
     4501 tgaaaatgat gtcactgcag gacacgcagc gtctatcgga caagttgatc cagaagacat
     4561 gtattacctc atgagtcgtg gattggataa ggcaactgca gagcgtttgg ttgttcgtgg
     4621 tttccttgga tctgttatcg tggagattcc agtcaaggaa gttcgtgatg aaatgattgc
     4681 aactatcgaa gagaaattgt caaaacgcta aggggaagcc tatgttagat gtagaagcga
     4741 ttcgcaagga ttttccaatt ttagatcaga ttgtcaatga tgaacctctg gtctatctgg
     4801 acaatgctgc gacgacacaa aaaccactag tagttctgaa agctattaac agctactatg
     4861 aacaggacaa tgccaatgtt caccgtggtg tccatacctt agcggaacga gcgacagctt
     4921 cttatgaagc tgctcgtgaa accattcgta agtttattaa tgcatgctct acaaaggaag
     4981 ttctctttac cagaggaacg acaaccagcc ttaactgggt ggcacgcttt gctgaggaaa
     5041 ttctcactga gggagaccag gtcttgattt cagtaatgga acaccattct aatatcattc
     5101 catggcagga agcttgtcga aagactggag cagagcttgt ctatgtctat cttaaagacg
     5161 gtgccttgga tatggaggat ttgcgagcta aattgactga taaggttaaa tttgtttccc
     5221 tagctcatgc ctccaatgtt cttggtgtgg tcaatccgat taaggaaatc actcaattag
     5281 cccaccaagt tggggcaatc atggtagtgg atggtgctca atctacacct catatgaaga
     5341 ttgatgtcca ggacttggat ctggactttt tcgccttttc gggtcacaag atggctggtc
     5401 cgactggtat cggtgtcctt tacggcaaag aaaagtatct tgagcaaatg tctccagtag
     5461 aatttggcgg cgagatgatt gattttgtct acgagcaatc cgctagttgg aaggaattgc
     5521 cttggaaatt tgaggctgga acgccaaata tggcaggagc tattggactt gcgactgcag
     5581 ttgattatct ggaaaagatt ggtatggatg ccgttgaagc tcatgaacag gaattgattg
     5641 cgtacgtcta tccaaaactg caggcaattg agggattgac catttacggt tctcaggatt
     5701 tggctcaacg ttcgggtgtt attgccttta acctaggtga tctccatcct cacgatcttg
     5761 cgacggctct ggattatgaa ggagtggctg ttcgtgctgg tcaccattgt gcgcaaccct
     5821 tgcttcagta tttggaagtc ccagcatcag ctcgtgcaag tttttatatc tacaatacca
     5881 aggcagattg cgacaaacta gtcgatgccc tacaaaagac aaaggagttt ttcaatggca
     5941 ctttctaaac tagatagcct ttatatggca gtggtagcag accattcgaa aaatccacat
     6001 caccaaggga agttagaaga tgctgagcaa atcagtctca acaatccgac ttgtggggat
     6061 gtcatcaacc tctctgtcaa gtttgatgca gaggaccgtt tggaagatat tgcttttcta
     6121 aattcaggat gcacgatttc aactgcttct gctagtatga tgacagatgt cgttttagga
     6181 aaaaccaaac aagaaatttt agaactggcg actatttttt ctgaaatggt tcaagggcaa
     6241 aaagatgagc gtcaaggcca acttggagac gcggcattct tgtcaggtgt tgccaaattc
     6301 cctcaaagaa tcaagtgtgc aaccctagct tggaatgccc ttaagaaaac aattgaaaat
     6361 caagaaaaac agtaagacaa gtttcttttg tcttatgaat tattagaaat gaagaaagaa
     6421 aggatactat ggctgaagaa agagtagaac caaaaccaat tgaccttggt gaatataaat
     6481 ttggtttcca tgacgatgta gagcctgtct tatcgacagg aaaaggactc aacgaaggtg
     6541 ttattcgtga attatctgct gctaagggtg agcctgagtg gatgttggag ttccgtttga
     6601 agtcttatga aaccttcaaa aaaatgccca tgcaaacttg gggagcagac ttgtcagaga
     6661 ttgactttga tgacttaatc tactaccaaa aaccatctga caaaccagcc cgttcttggg
     6721 atgatgtacc tgaaaagatt aaagaaacct ttgaacgtat cgggattcca gaagctgaac
     6781 gtgcttattt agcaggggct tctgcccagt acgagtcaga agtggtttac cacaacatga
     6841 aggaagagtt ccaaaaatta ggtattatct ttacagatac agattccgca ctcaaggaat
     6901 acccagactt atttaaacaa tactttgcga agttggtacc gccgacagat aacaagttgg
     6961 cagccctcaa ctcagcagta tggtcgggtg gaacttttat ctacgtgcca aaaggtgtca
     7021 aggtagatat tccacttcaa acttatttcc gtatcaataa cgaaaatata ggtcagttcg
     7081 aacgtacctt gattatcgtt gatgagggag caagcgtcca ctacgtagaa ggatgtacag
     7141 caccaacata ttcaagcaat agcttacacg ctgccattgt agaaattttt gctttggacg
     7201 gagcttatat gcgttataca actatccaaa actggtctga taacgtctat aacttggtaa
     7261 caaagcgtgc taaggctcaa aaggatgcca ctgttgagtg gattgatgga aacttgggtg
     7321 ccaaaacgac tatgaaatat ccatctgttt accttgatgg agaaggagcg cgtggtacca
     7381 tgctctctat cgcctttgct aatgcagggc aacaccaaga cacgggtgct aagatgattc
     7441 acaatgctcc acataccagc tcgtctattg tgtctaaatc catcgctaaa ggtggaggaa
     7501 aggttgacta ccgtggacaa gtcaccttta acaagaactc taagaaatct gtttcccaca
     7561 ttgaatgtga taccattatc atggatgact tgtcagcatc agatactatt ccatttaatg
     7621 aaattcacaa ctcgcaagta gctttggaac acgaagccaa agtatctaag atttcagaag
     7681 agcaattgta ttatcttatg agccgtggat tgtcagaatc tgaggcaact gaaatgattg
     7741 tcatgggatt tgtagaaccc tttacaaaag aacttccaat ggaatacgca gttgagctga
     7801 accgcttgat tagctatgaa atggagggat cagttggata aaatttgatt ttatactctt
     7861 cgaaaatctc ttcaaaccac gtcagcatcg ccttaccgta tgtatggtta ctgacttcgt
     7921 cagtttcatc tacaacctca aaacagtgtt ttgagcaacc tgcggctagc ttcctagtta
     7981 gttctttgat tttgagtatt agatttactc aaaatcaagg attttgaaga tgaacttgta
     8041 tcaaaaaatc gcggtttaaa atcgcgattt tttataattt ctcgttaaca aagcggacaa
     8101 actgattcca ccaaactttt aagaagaagg ctttttcaat tttcttgtct gctaccattt
     8161 cgaaactagg gcgctctgtg gtgatgtaac cttgaccaat caagtccttg tcttcataag
     8221 tcaaatggcc aaccactgtt ccagcttcaa gtggtgctgg gattgctttg gaatcaggtg
     8281 tgaattgaac agattgggaa gattgattcc caacacgttc gattagatag atatcctctg
     8341 gagccactgc agttactgta tcttcttttc catcttgtac aggggctttg ctatcttgat
     8401 aggcatcgcc ttgttgaacg attttgcgaa gtgtaaatgt agaagaaata taatccatta
     8461 gggaagatgt agctgtaaat cgagcgtaag gattattgtc ttgatgatct gcatttaaaa
     8521 caactgtgat gactctcatg cctttttcga cagtagtacc aacaaaagac tctccagcct
     8581 tatctgttgt tcctgttttt agcccatcaa aaccaccacg gtaagcaggc ataccttcta
     8641 acatgtagtt ggttgaagtg attgtcatcc cagcaaaagt agaagaaggt tttttggtga
     8701 tttctaagac ttgtgggtat tttttgatga ggttgcgagc aacgatagcg acatcataag
     8761 cactaagctt attttcctca tcttttttag aacctgggta aatgttatcc cctagagttt
     8821 cattgttaag acctgtcgta ttgacaacag tggcatcctg aattccccat tccaagagtt
     8881 ttgcccgcat catatcgacg aaatcttttt ctgagccagc aattttctca gctagggcaa
     8941 tagcggcgct gttggcacta gataccagag ttgcttcaag caactcttcg acagtataat
     9001 tacgggcctc cataggaata ttactggctt cagaatttgt cgtcaattga taaggataat
     9061 cagaaatatc tacaggagtg gagagggtaa tacttccgtt ttccaaagct tcatagacca
     9121 gataaacagt aatcaatttt gttatggaag caatttcgac aggttgcgtt gcatccttct
     9181 catagagaat tttaccagta tttgcctcaa cagcaatcgc atgtttagcg gcaatggtaa
     9241 aatcttgagc aacagcagta gaagcacccc ctaaaagaga gacagttaac aaagttaaaa
     9301 atattttttt catagtagtc ttattctatc ataaagaaaa aaaatattct tgctttaata
     9361 attcatctgt taagcttttt gaaaatatgg taaaataaag tgagggaggt aactcatgtt
     9421 tcgtagaaat aaattatttt tttggaccac agaaatttta ctcttaacca tcatctttta
     9481 tctatggaga cagatggggt ctttgattaa cccttttgtt agcgtgctta atacaattat
     9541 gattccattt ttattagggg gctttcttta ttatttgaca aaccctattg ttactttctt
     9601 aaataaagtc tgtaaactca atcgtttgct tggtatttta attaccttgt gtactttgat
     9661 ctggggaatg gtcataggtg ttgtctatct cttacctatt ttgattaatc agttatctag
     9721 tttgattata tctagtcaaa ctatttatag tcgagtacaa gacttaatca tagacttatc
     9781 taattatcct gcgctccaga atttggatgt agaagctaca attcagcagt taaacttatc
     9841 ctatgttgat attcttcaaa atatcctaaa tagcgtatca aatagtgtgg ggagcgtctt
     9901 gtcagctctt atcagtactg ttttgatttt gattatgact ccagtttttt tggtttattt
     9961 cttattagat ggacataaat tcttgcccat gcttgaaaga acgattctaa agagggatcg
    10021 cttgcatatt gcaggcttat taaagaattt aaatgcgacg attgctcgct atattagtgg
    10081 agtttcgatt gacgcaatca ttataggttg tttggcttat attggctata gtattattgg
    10141 tttaaaatat gctttagttt ttgccatttt ttctggtgta gccaatttaa ttccttatgt
    10201 ggggccaagt attggtttga ttcctatgat catcgcaaat atattcactg atccccatag
    10261 actgctgatt gcagtgattt atatgcttgt tgttcagcag gtagatggca atatcttata
    10321 tcctcgaatc gtaggaagtg ttatgaaggt tcatccaatc acgattttag ttttactttt
    10381 gttgtcaagc aatatctatg gtgtagttgg aatgattgtc gcagtgccaa cctattctat
    10441 cttgaaagaa atttctaagt tcttatcccg tttgtatgaa aatcataaaa taatgaaaga
    10501 acgagaaaga gaattagcta agtaaaagtc aggagaaccc tgatttttct ttactggaag
    10561 tggcctttag attagaagac tgaaaataag ttaaagtctt aaactaattt tcacagctaa
    10621 gaatagtaga agttaatctg ataaaaatcg aaaaaaccag tggaattccg tgtcagggta
    10681 agttccactg gttttcatag tctattaaag ttcgaatgaa acctatttat agtatattga
    10741 aactagaata gtacacctct aattctaaaa cattgttaga aatcgatttg actgtcctga
    10801 tctattcgtc ctattctt
//
LOCUS       DAVLHC010000057        10778 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.058, whole genome shotgun sequence.
ACCESSION   DAVLHC010000057 DAVLHC010000000
VERSION     DAVLHC010000057.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10778)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10778)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10778
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.058"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..185
                     /locus_tag="VXE25_001802"
     CDS             <1..185
                     /locus_tag="VXE25_001802"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001818644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEV0772221.1"
                     /translation="EYENRTVSFAISSKGEKMKVENISYRVDHRKLFDNISFDTSSSD
                     VTLITGKNGTGKSTLL"
     gene            complement(551..1861)
                     /locus_tag="VXE25_001803"
     CDS             complement(551..1861)
                     /locus_tag="VXE25_001803"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000581523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SLC13 family permease"
                     /protein_id="HEV0772222.1"
                     /translation="MIHLIMISAIALAIGIGYRTKINIGLLAIAFSYLIATTLMGLSP
                     KELLHFWPTSLFFTIFSVSLFYNVATTNGTLDVLAQHILYRTRTHPNALYMILYLMAT
                     LLSALGAGFFTTMAVCCPLAITLCQKADKHPLIGAQAVNWGASGGANLITSSSGIVFQ
                     GLFKQMGWEEQAFSLGNHIFIVSIIYPLIVLLLLSCYSHYSKGRTNSSLTIDQPPLLS
                     KVQRQTTLLMISSMVLVWLFPLLHLIFPNIAWIATYQKTFDIGFVSILMVCLALRLKL
                     GKQEAILAKVPWATIIMLCGMSLLMSLAVKSGLVTLIGHLMTTTIPHFWLPLFFCVIA
                     GVMSLFSSTLSVVAPALFPIIAIISAQNPQIDIHLLTTATVIGALSTNISPFSSAGSL
                     IQLSLPNIEERGLAFKKQIILGVPISLSLGLLTTWILILLASLS"
     gene            2098..2970
                     /locus_tag="VXE25_001804"
     CDS             2098..2970
                     /locus_tag="VXE25_001804"
                     /EC_number="2.4.2.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000022746.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carboxylating nicotinate-nucleotide
                     diphosphorylase"
                     /protein_id="HEV0772223.1"
                     /translation="MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKV
                     SLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLL
                     TCERVALNFLQHLSGIASMTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGY
                     NHRFNLSDAILLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGA
                     DIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAK
                     SLDFSMKGLTYLDV"
     gene            3101..3947
                     /locus_tag="VXE25_001805"
                     /pseudo
     CDS             3101..3947
                     /locus_tag="VXE25_001805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="programmed frameshift; internal stop; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
     gene            4008..4970
                     /locus_tag="VXE25_001806"
     CDS             4008..4970
                     /locus_tag="VXE25_001806"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HEV0772224.1"
                     /translation="MNMSNITIDGQEMDLSQTMPSYAQVVSLYDDTSISVSNNETDKV
                     LAGSLYTDTNEQGLTIPSSLLKNWNEQTGKNLTANDLIGKSVSASIVESAAETSKIAQ
                     FQTKIVRVINDEDDMEDSNSFMLSHQMETILKEAGFTKAVSYFILELKDPSQTKVVTE
                     ELQKNKKYTVLSQQRVLDIVITFIRVIQGLLIVLSSQAIVVAAVMIGIIIYINIMQRS
                     KEIGVMKAVGYQNRDVKGIFIYEAIWIVGIALLLAFLVAQGVGSLANAIVSHFYPSIT
                     KVFELNLLSVLGTLVFALLLGYVSAYFPARKISKMDPIESLCYE"
     gene            5147..6154
                     /gene="gap"
                     /locus_tag="VXE25_001807"
     CDS             5147..6154
                     /gene="gap"
                     /locus_tag="VXE25_001807"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008090210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I glyceraldehyde-3-phosphate dehydrogenase"
                     /protein_id="HEV0772225.1"
                     /translation="MVVKVGINGFGRIGRLAFRRIQNVEGVEVTRINDLTDPVMLAHL
                     LKYDTTQGRFDGTVEVKEGGFEVNGKFIKVSAERDPEQIDWATDGVEIVLEATGFFAK
                     KEAAEKHLKGGAKKVVITAPGGNDVKTVVFNTNHDVLDGTETVISGASCTTNCLAPMA
                     KALQDNFGVVEGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIG
                     LVIPELNGKLDGSAQRVPTPTGSVTELVAVLEKNVTVDEVNAAMKAASNESYGYTEDP
                     IVSSDIVGMSYGSLFDATQTKVLDVDGKQLVKVVSWYDNEMSYTAQLVRTLEYFAKIA
                     K"
     gene            complement(6222..7058)
                     /locus_tag="VXE25_001808"
     CDS             complement(6222..7058)
                     /locus_tag="VXE25_001808"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000216776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HEV0772226.1"
                     /translation="MTVKQLLEEQLLIPRKIRHFLRIKKHILINQEEVHWKEIVNPGD
                     VCQLTFDEEDYSQKTIPWGNPDLVQEVYQDQHLIIVNKPEGMKTHGNQPNEIALLNHV
                     STYVGQTCYVVHRLDMETSGLVLFAKNPFILPILNRLLEKKEISREYWALVDGNINRK
                     ELVFRDKIGRDRHDRRKRIVDAKNGQYAETHVSRLKQFSNKTSLAHCKLKTGRTHQIR
                     VHLSHHNLPILGDPLYNSKSKTSRLMLHAFRLSFTHPLTLEKLTFTTLSNTFEKELKK
                     NG"
     gene            7184..9379
                     /locus_tag="VXE25_001809"
     CDS             7184..9379
                     /locus_tag="VXE25_001809"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000762602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein"
                     /protein_id="HEV0772227.1"
                     /translation="MKLDKLFEKFLSLFKKETSELEDSDSTILRRSRSDRKKLAQVGP
                     IRKFWRRYHLTKIILILGLSAGLLVGIYLFAVAKSTNVNDLQNALKTRTLIFDREEKE
                     AGALSGQKGTYVELTDISKNLQNAVIATEDRSFYKNDGINYGRFFLAIVTAGRSGGGS
                     TITQQLAKNAYLSQDQTVERKAKEFFLALELSKKYSKEQILTMYLNNAYFGNGVWGVE
                     DASKKYFGVSASEVSLDQAATLAGMLKGPELYNPLNSVEDSTNRRDTVLQNMVAAGYI
                     DKNQETKAAEVDMTSQLHDKYEGKISDYRYPSYFDAVVNEAVSKYNLTEEEIVNNGYR
                     IYTELDQNYQANMQIVYENTSLFPRAEDGTFAQSGSVALEPKTGGVRGVVGQVADNDK
                     TGFRNFNYATQSKRSPGSTIKPLVVYTPAVEASWALNKQLDNHTMQYDSYKVDNYAGI
                     KTSREVPMYQALAESLNLPAVATVNDLGVDKAFEAGEKFGLNMEKVDRVLGVALGSGV
                     ETNPLQMAQAYAAFANEGLMPEAHFISRIENASGQVIASHKNSQKRVIDKSVADKMTS
                     MMLGTFTNGTGISSSPADYVMAGKTGTTEAVFNPEYTSDQWVIGYTPDVVISHWLGFP
                     TTDENHYLAGSTSNGAAHVFRNIANTILPYTPGSTFTVENAYKQNGIAPANTKRQVQT
                     NDNSQTDDNLSDIRGRAQSLVDEASRAISDAKIKEKAQTIWDSIVNLFR"
     gene            9432..9584
                     /gene="rpmG"
                     /locus_tag="VXE25_001810"
     CDS             9432..9584
                     /gene="rpmG"
                     /locus_tag="VXE25_001810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015912025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L33"
                     /protein_id="HEV0772228.1"
                     /translation="MALKKASLACAVCGSRNYSIKISGNLKPTRLEVNKFCKHCGKYT
                     THRETR"
     gene            9594..9770
                     /gene="secE"
                     /locus_tag="VXE25_001811"
     CDS             9594..9770
                     /gene="secE"
                     /locus_tag="VXE25_001811"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001211016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecE"
                     /protein_id="HEV0772229.1"
                     /translation="MRFIGDIFRLLKDTTWPTRKESWRDFRSIMEYTAFFVVIIYIFD
                     QLIVSGLIRFINIF"
     gene            9825..10361
                     /gene="nusG"
                     /locus_tag="VXE25_001812"
     CDS             9825..10361
                     /gene="nusG"
                     /locus_tag="VXE25_001812"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000376740.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination/antitermination
                     protein NusG"
                     /protein_id="HEV0772230.1"
                     /translation="MDSFDKGWFVLQTYSGYENKVKENLLQRAQTYNMLDNILRVEIP
                     TQTVQVEKNGKRKEVEENRFPGYVLVEMVMTDEAWFVVRNTPNVTGFVGSHGNRSKPT
                     PLLEQEIRDILVSMGQTVQEFDFDVEIGQTVRIIDGAFADYTGKITEIDNNKVKMIIS
                     MFGNDTVAEVNLNQIAEL"
     gene            10483..>10778
                     /locus_tag="VXE25_001813"
     CDS             10483..>10778
                     /locus_tag="VXE25_001813"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000588926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HEV0772231.1"
                     /translation="MIKELYEEVQGTVYKCRNEYYLHLWELSDWEQEGMLCLHELISR
                     EEGLVDDIPRLRKYFKTKFRNRILDYIRKQESQKRRYDKEPYEEVGEISHRISEG"
BASE COUNT         3390 a         1849 c         2357 g         3182 t
ORIGIN      
        1 aagagtatga aaacagaact gtttcttttg ctattagttc aaaaggagaa aaaatgaaag
       61 tagaaaatat ttcgtatagg gtggatcatc gtaaattgtt tgataatatt tcttttgata
      121 cttcgagttc agacgtgaca ttaattactg gtaaaaatgg tacaggaaag tcaactttac
      181 tatagtagat tgaaactaga atagtacaca tctacttcta aaatattgtt agaaatcgat
      241 ttgactatcc tgatctattt gtcctgttct tatttcattt cactatatct caaattgagt
      301 atgacgaagt gcgctcccat gtcctgggaa cgcactttct tcatattttt catattcttg
      361 aatccatcga taaagactat tgggatgaat ttttaaagtt gaactaatca tttttacagg
      421 atgagattta cagcagagag tttgaaggct ttatcaaagg tttttcttgg cataatgact
      481 tttcctcgtt tccacttaat tttgtgtcta ctttattata ccaagtccac ccttaagtta
      541 gataataaat ctaacttaag gaagctagaa ggatgagaat ccaggtggtc aagagtccca
      601 aacttaagct gatggggaca cccagaataa tttgcttttt gaaggcaagg ccacgttcct
      661 ctatattggg aagtgagagt tgaatgagag aaccagctga tgaaaagggt gagatattag
      721 tagatagagc gccaataacg gtggctgttg tgagtaagtg aatatcaatc tgaggatttt
      781 gagcactgat gatagcaatg atgggaaaga gggctggagc tacaacggat agggtggaac
      841 taaagagtga catcactccg gctatcacac aaaagaacag aggtaaccag aaatgaggaa
      901 tggttgttgt catgaggtgc cctatcagtg tgactaaacc tgacttgacc gctagagaca
      961 ttagtaagct catgccgcag agcatgataa ttgtagccca gggaacctta gctaaaatgg
     1021 cttcttgctt ccctaatttg agccttaagg cgaggcagac catgagtatt gagacaaagc
     1081 caatatcaaa tgttttttga taagtagcta tccaggcgat gtttgggaaa atgagatgca
     1141 acaagggaaa aagccaaacc aaaaccatgc tgctgatcat gagcaaggtg gtttgtcttt
     1201 gaaccttgct gaggagtggt ggttggtcaa tagtcaagga tgagtttgtt cttcccttac
     1261 tatagtgact gtaacaggat aataaaagca agacgatgag tgggtagata atgctgacga
     1321 taaagatatg attgccaagt gaaaaagctt gctcttccca tcccatttgc ttaaacaggc
     1381 cttgaaagac aatgcctgag ctactggtta tcaaattagc ccctcctgaa gctccccaat
     1441 tgacggcttg agctccaatc aaagggtgtt tgtccgcttt ttgacagagg gtaatcgcta
     1501 gaggacagca aacggccata gtagtgaaaa atccagcacc taaagcagac aaaagggttg
     1561 ccatcaggta taaaatcatg tagagggcgt tagggtgggt gcgtgtgcgg tagagaatgt
     1621 gttgagccaa aacatcaaga gtaccgttag ttgttgcaac gttataaaag agagagacgc
     1681 taaaaatggt aaaaaagagt gaggttggcc aaaaatgaag aagttctttg gggcttaatc
     1741 ccatgagagt ggttgcgatg aggtaagaaa aagcaatagc cagcaggcca atattgattt
     1801 tggtgcggta accaattcca atggctagag caatggcgct aatcattatt aaatgaatca
     1861 ttgaattgtc ctttcagtta gaatatggaa ataggttggc aattttggcg ctcaaaagac
     1921 cacctgtttc ctattggtac ttgactatta tacacaaaaa aaatacaatt gtcttgacaa
     1981 ttgtattgac acttgttaga attaaaaatg aggtattcag gcttgtgatt tcctatggaa
     2041 gttaatagtg attgcctcta atgcttacaa gtgatattaa aaatagagga cctagtgatg
     2101 tcaatcattt caactgattt aacccctttt caaatagatg atacattgaa agcagccttg
     2161 cgagaagatg ttcattccga agattacagt accaatgcca tttttgatca tcatggccaa
     2221 gccaaggtgt cgctttttgc caaggaagct ggtgttttag cggggctaac cgtttttcaa
     2281 agggttttta ccctatttga tgccgaggtg accttccaga atcctcatca atttaaggat
     2341 ggggatcgtt tgactagtgg cgatttggtt ttagaaatca taggctcggt gagaagtctc
     2401 ttaacatgtg aacgcgttgc cttgaatttt ttacaacatt tatcagggat tgcttcgatg
     2461 acagctgctt atgtagaagc cttaggcgat gattgcatta aggtatttga tactcgaaaa
     2521 actactccta atttacgtct ttttgagaaa tatgccgtga gagttggcgg tggctataat
     2581 catcgcttta atttatcaga tgctatcctg ctaaaagaca atcacattgc ggcagtaggt
     2641 agtgttcaaa aggcaattgc tcaagcgcgt gcctatgccc cttttgtgaa aatggtcgag
     2701 gtggaagtgg aaagccttgc tgctgccgaa gaagctgcgg cggcgggtgc tgatattatc
     2761 atgttggata atatgtcatt ggaacagatt gaacaggcca ttaccctaat tgcaggacgt
     2821 tctcggattg aatgttctgg aaatattgat atgaccacta ttagccgttt tcgtggttta
     2881 gcgattgatt acgtctccag tggtagttta acccatagtg ctaagagtct tgatttttcc
     2941 atgaaggggt taacctacct tgatgtctaa gttgtaaaat aaactaactt tttaaaggat
     3001 gtctttcctc tagaacgagt tttatgtcag atagtttaaa cgcctcttca aatatagtaa
     3061 aatgaaccaa aaatagtaca caatgtggta taatcttttt atggcatatt caatagattt
     3121 tcgtaaaaaa gttctctctt attgtgagcg aacaggtagt ataacagaag catcacacgt
     3181 tttccaaatc tcacgtaata ccatttatgg ctggttaaag ctaaaagaga aaacaggaga
     3241 gctaaaccac caagtaaaag gaataaaacc aagaaaggtt gatagagata gacttaaaaa
     3301 ctatcttact gacaatccag acgcttattt gactgaaata gcttctgaat ttggctgtca
     3361 tccaactacc atccactatg cgctcaaagc tatgggctac actcgaaaaa aagaaccaca
     3421 cctactatga acaagaccca gaaaaagtag ccttatttct taagaatttt aatagcttaa
     3481 agcacctaac acctgtttag attgacgaaa caggattcga tacttatttt tatcgagaat
     3541 atggtcgctc attaaaaggt cagttaataa gaggcaaagt atctggaaga agatatcaga
     3601 ggatttcttt ggttgcaggt ctaacaaatg gtgagttaat cgctccaatg acttacgaag
     3661 agatgatgac gagcgacttt tttgaagtat ggtttcagaa gtttttctta ccaacattaa
     3721 ccacaccatc ggttattatt atggataatg caagattcca tagaatgggt aagctagaac
     3781 tcttgtgtga agagtttggg cataaacttt tacctcttcc tccctactca cctgagtaca
     3841 atcctattga gaaaacatgg gctcatatca aaaagcacct caaaaaggta ttaccaagtt
     3901 gcaatacctt ttacgaggct tttttatcct gctcttgttt caattgacta tatatcacgg
     3961 atacagttgg gaaagaagct attaaatatt tggagagtcc ttttgggatg aacatgtcaa
     4021 atattactat agatgggcaa gaaatggatc tgagtcaaac gatgccttct tatgctcaag
     4081 tagtgagtct ttatgatgat acaagtatct ctgttagtaa taatgagacg gacaaagtgt
     4141 tggctggatc cctctatact gatacaaatg aacagggatt aacgattcca agcagtttac
     4201 taaaaaattg gaatgaacag acaggaaaaa atttgacagc taatgatctt attggcaaat
     4261 cagtctcagc cagcattgta gaaagtgctg ccgaaactag taagattgct caatttcaaa
     4321 cgaagattgt acgtgtaatc aatgatgaag atgacatgga ggacagcaac agtttcatgc
     4381 tgtctcatca aatggaaacg attttgaaag aggctggatt tacgaaagct gtatcttatt
     4441 ttatcttgga actcaaagat ccatcacaga caaaagtagt aacagaagaa ttacagaaaa
     4501 ataagaagta tactgtgctt tctcaacaga gagttcttga tattgtgatt acctttattc
     4561 gtgttattca gggattattg attgtgcttt catcacaagc tattgtggta gcagcggtta
     4621 tgattggtat cattatttac atcaatatca tgcaacgttc caaggaaata ggtgtcatga
     4681 aagcagttgg ttatcagaat cgtgatgtca aaggaatttt tatttacgag gctatctgga
     4741 ttgtaggcat cgccttgctg ctggcatttt tggttgcaca aggggtggga agtttggcga
     4801 atgcgattgt aagtcacttt tacccatcca tcactaaggt ttttgaatta aatcttttat
     4861 ctgttttagg aactctagtt ttcgctctat tacttggtta tgtctcagcc tacttcccgg
     4921 cgcgtaagat tagtaaaatg gatcctatag aatcgttatg ctatgaatag taagggattc
     4981 cttggtttac agtcttaaaa agaaactaac atagaaaaac aatggccata cttgcaattc
     5041 aactcaaata gttgtataat aggtttgttg aaaggtgatt tgtagtgatt caagttactc
     5101 ttttcacaat aaaaatttca tgattttcat aaggaggaaa tcactaatgg tagttaaagt
     5161 tggtattaac ggtttcggac gtatcggtcg tcttgctttc cgtcgtatcc aaaacgtaga
     5221 aggtgttgaa gttacacgca tcaacgacct tacagatcca gttatgcttg cacacttgtt
     5281 gaaatacgac acaactcaag gtcgtttcga cggtactgtt gaagttaaag aaggtggatt
     5341 tgaagttaac ggtaaattca tcaaagtttc tgctgaacgt gatccagaac aaatcgactg
     5401 ggctactgac ggtgtagaaa tcgttcttga agctactggt ttctttgcta agaaagaagc
     5461 agctgaaaaa caccttaaag gtggagctaa aaaagttgtt atcactgctc ctggtggaaa
     5521 cgacgttaaa acagttgtat tcaacactaa ccacgacgtt cttgacggta ctgaaacagt
     5581 tatctcaggt gcttcatgta ctacaaactg cttggctcca atggctaaag ctcttcaaga
     5641 caactttggt gttgttgaag gattgatgac tactatccac gcttacactg gtgaccaaat
     5701 gatccttgac ggaccacacc gtggtggtga ccttcgccgt gctcgcgctg gtgctgcaaa
     5761 catcgttcct aactcaactg gtgctgcaaa agctatcggt cttgtaatcc cagaattgaa
     5821 tggtaaactt gacggatctg cacaacgcgt tccaactcca actggatcag ttactgaatt
     5881 ggtagcagtt cttgaaaaga acgttactgt tgatgaagtg aacgcagcta tgaaagcagc
     5941 ttcaaacgaa tcatacggtt acacagaaga tccaatcgta tcttcagata tcgtaggtat
     6001 gtcttacggt tcattgtttg acgcaactca aactaaagtt cttgacgttg acggtaaaca
     6061 attggttaaa gttgtatcat ggtacgacaa cgaaatgtca tacactgcac aacttgttcg
     6121 tactcttgaa tacttcgcaa aaattgctaa ataattcttg agttgataga aagcaaggct
     6181 ttgtggtctt gcttttttat atggaaaaat ggatgacacg atcatccatt cttttttaat
     6241 tctttttcaa atgtatttga aagggtagtg aaagttagct tctctaaagt aagtgggtgg
     6301 gtaaaggaaa gtcggaaggc atgaagcata agccggcttg tctttgattt actattatag
     6361 agagggtctc ccaggatagg aagattatga tgcgaaaggt gcacacgaat ctgatgggtt
     6421 cgccctgtct ttagcttgca atgagccaag gaagtcttgt ttgagaattg ctttaatctg
     6481 cttacatgcg tttcagcata ttgcccattt tttgcatcaa ctattctttt tctacgatca
     6541 tggcgatcac gtccaatttt gtctctgaaa acaagttctt ttctgttgat atttccatca
     6601 actagagccc aatattctct agaaatctct tttttctcca ataagcgatt gagaatgggc
     6661 aggataaaag gatttttggc aaagagaact aagccactgg tttccatgtc cagacgatga
     6721 acgacatagc aggtttggcc aacataggta ctgacatggt taagaagggc aatttcgttt
     6781 ggttgattac catgcgtttt catcccctct ggtttgttta caataatcaa gtgttgatct
     6841 tgataaactt cctgcactaa gtctgggttg ccccaaggga tcgtcttttg ggaataatct
     6901 tcctcgtcaa aagtcaactg gcaaacatct ccaggattta cgatttcctt ccagtggact
     6961 tcttcttgat ttatcaaaat atgtttcttg attctcaaaa aatgacggat ttttctaggg
     7021 atgaggagtt gttcctcaag taattgcttt actgtcattt gaggtagaga ggcgggtaat
     7081 gtaaatgtga attgcataca gatattgtaa caaaaaaagc cctatttgga taggaaatag
     7141 ctaaattctt gtcttcctat gatgaagatg ataaaataaa cgcatgaaat tagataaatt
     7201 atttgagaaa tttctttctc tttttaaaaa agaaacaagt gaactagagg actctgattc
     7261 tactatctta cgtcgctctc gtagtgatcg aaaaaaatta gcccaagtag gtccgattcg
     7321 aaaattctgg cgtcgttatc atctaacaaa gattatcctt atactaggtt tgagtgcagg
     7381 cttgctagtt ggaatctatt tgtttgctgt agccaagtcg accaatgtca atgatttgca
     7441 aaatgccttg aaaactcgga ctcttatttt tgaccgtgaa gaaaaagagg ctggtgcctt
     7501 gtctggtcaa aagggaacct atgttgagct gactgacatc agtaaaaact tgcagaatgc
     7561 tgttattgcg acagaagacc gttctttcta taaaaatgac gggattaact atggccgttt
     7621 tttcttggct attgtcactg ctggacgttc aggtggtggc tctaccatta cccaacagct
     7681 ggctaaaaac gcctatttat cgcaggatca aactgttgag agaaaagcga aagaattttt
     7741 ccttgcctta gaattaagca aaaaatatag taaggagcaa attctaacca tgtaccttaa
     7801 caacgcttat tttggaaatg gtgtgtgggg tgtagaagat gcgagtaaga aatactttgg
     7861 agtttctgca tcagaagtga gtctggatca agctgcgact ctggcaggga tgctcaaggg
     7921 gccggaactg tataatccct tgaattccgt agaagattct actaatcggc gcgatactgt
     7981 cttgcagaat atggttgcag caggatatat tgataaaaac caagaaacca aagctgctga
     8041 agttgatatg acttcgcaat tgcacgataa gtatgaagga aaaatctcag attaccgtta
     8101 cccctcttat tttgatgcgg tggttaatga agctgtttcc aagtataatc taacagagga
     8161 agagattgtc aataatggct accgcattta cacagagctg gaccaaaact accaagcaaa
     8221 tatgcagatt gtttatgaaa acacatcgct atttccgagg gcagaggatg gaacgtttgc
     8281 tcaatcagga agtgtagccc tcgaaccgaa aacaggggga gttcgtggag ttgtcggtca
     8341 agttgctgac aatgataaaa ctggattccg gaatttcaac tatgcaaccc aatcaaagcg
     8401 tagtcctggt tctacaatta agcctttagt tgtttatacg ccagcagttg aagcaagctg
     8461 ggctttgaat aagcagttgg ataaccatac catgcagtat gacagctata aggttgataa
     8521 ctatgcaggg atcaaaacga gtcgagaagt tcctatgtat caagccttgg cagaatcgct
     8581 taatctacct gctgttgcca ctgttaatga tttgggtgtc gacaaggctt ttgaggcagg
     8641 cgaaaaattc ggactcaaca tggaaaaggt cgaccgtgtt cttggtgtcg ccttgggaag
     8701 cggtgttgaa accaaccctc ttcaaatggc tcaagcatac gccgcctttg caaatgaagg
     8761 tttaatgcct gaagctcatt ttattagtag aattgaaaat gctagtggac aagttattgc
     8821 gagtcataaa aattcacaaa aacgggtgat tgataagtct gtagctgaca agatgaccag
     8881 tatgatgttg gggactttca ccaacggtac cggtattagt tcatcgcctg cagactatgt
     8941 catggcaggg aaaactggaa caactgaagc agttttcaat ccggagtaca caagtgacca
     9001 gtgggtaatt ggttatactc cggatgtagt gattagccac tggcttggct ttccgaccac
     9061 tgatgaaaac cactatctag ctggctctac ttcaaacggt gcagctcatg tctttagaaa
     9121 cattgccaat accattttac cttatacgcc aggaagtacc tttacggttg aaaatgctta
     9181 taagcaaaat ggaattgcac cagccaatac aaaaagacaa gtacaaacca atgataatag
     9241 ccagacagat gataatttgt ctgatattcg agggcgtgcg caaagtctag tagatgaggc
     9301 tagccgggct atctcagatg cgaagattaa ggaaaaggct caaacaatat gggattcgat
     9361 agtcaatcta tttcgctaag atgcttgtca aagcctagct ttcttgttat aatggataag
     9421 atggaggcgt tatggcacta aaaaaagcaa gcctagcttg tgcggtttgt ggttcgagaa
     9481 actattcaat caagatcagc ggaaacctca agcctacacg actagaagta aataaatttt
     9541 gtaagcattg tggcaagtac actacacaca gagaaacgag ataggagaga gcgatgcgtt
     9601 ttattggaga tatttttaga cttcttaaag acacaacatg gccaactcgc aaggaaagct
     9661 ggagagattt tcgttctatc atggaataca cagctttctt tgtagtaatt atttacattt
     9721 ttgaccagtt gattgtttca ggtttgattc gatttattaa cattttttag aagattagtg
     9781 gagttaatta cactagaaat cttctattta tgaaaggaaa tatcatggat agttttgata
     9841 aagggtggtt tgttttacaa acttattctg gttatgaaaa taaggtgaaa gaaaatctat
     9901 tacaacgtgc acaaacctac aatatgttgg ataatattct acgcgttgaa attccaacac
     9961 aaacagtgca agttgaaaaa aatggaaaga gaaaagaagt agaagaaaat cgctttccag
    10021 gttatgttct tgtagaaatg gtcatgacag atgaagcttg gtttgttgtt cgaaacacac
    10081 caaatgttac aggatttgtc ggatcacacg ggaacagatc aaaaccaact ccattattgg
    10141 aacaagaaat tcgcgacatt ttggtatcta tgggacaaac tgttcaagaa tttgatttcg
    10201 atgttgagat tggtcaaact gtacgtatta ttgatggtgc ttttgcagac tacactggta
    10261 agattacaga aattgataat aacaaagtga aaatgattat ctctatgttt ggtaatgaca
    10321 cagttgcaga agtaaatcta aaccaaatcg cagaattata accctgagag aggctggagc
    10381 ttctcttttt tgtgcagttt aggagctaaa gggaacagaa tggagaaaat ggaacaaatg
    10441 tgttttctaa tctgttagac tgtatctaga aaggggaaaa ttatgattaa agaattgtat
    10501 gaagaagtcc aagggactgt gtataagtgt agaaatgaat attaccttca tttatgggaa
    10561 ttgtcggatt gggagcaaga aggcatgctc tgcttacatg aattgattag tagagaagaa
    10621 ggactggtag acgatattcc acgtttaagg aaatatttca agaccaagtt tcgaaatcga
    10681 attttagact atatccgtaa acaggaaagt cagaagcgta gatacgataa agaaccctat
    10741 gaagaagtgg gtgagatcag tcatcgtata agtgaggg
//
LOCUS       DAVLHC010000058        10639 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.059, whole genome shotgun sequence.
ACCESSION   DAVLHC010000058 DAVLHC010000000
VERSION     DAVLHC010000058.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10639)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10639)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10639
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.059"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(121..1545)
                     /locus_tag="VXE25_001814"
     CDS             complement(121..1545)
                     /locus_tag="VXE25_001814"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000199391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-dependent glyceraldehyde-3-phosphate
                     dehydrogenase"
                     /protein_id="HEV0772232.1"
                     /translation="MTRYQNLVNGKWKSSEQEITIYSPINQEELGTVPAMTQTEADEA
                     MQAARAALPAWRALSAVERAAYLHKTAAILERDKEEIGTILAKEVAKGIKAAIGEVVR
                     TADLIRYAAEEGLRITGQAMEGGGFEAASKNKLAVVRREPVGIVLAIAPFNYPVNLSA
                     SKIAPALIAGNVVMFKPPTQGSISGLLLAKAFEEAGIPAGVFNTITGRGSEIGDYIIE
                     HKEVNFINFTGSTPIGERIGRLAGMRPIMLELGGKDAALVLEDADLEHAAKQIVAGAF
                     SYSGQRCTAIKRVIVLESVADKLATLLQEEVSKLTVGDPFDNADITPVIDNASADFIW
                     GLIEDAQEKEAQALTPIKREGNLLWPVLFDQVTKDMKVAWEEPFGPVLPIIRVASVEE
                     AIAFANESEFGLQSSVFTNDFKKAFEIAEKLEVGTVHINNKTQRGPDNFPFLGVKGSG
                     AGVQGIKYSIEAMTNVKSIVFDVK"
     gene            complement(2090..4369)
                     /gene="pulA"
                     /locus_tag="VXE25_001815"
     CDS             complement(2090..4369)
                     /gene="pulA"
                     /locus_tag="VXE25_001815"
                     /EC_number="3.2.1.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000283081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I pullulanase"
                     /protein_id="HEV0772233.1"
                     /translation="MYNYPMRIHYHRKNGEYDTCSFVKSQDQRIDLLTYKEDYFGALF
                     SFEHPSSHVIESLNFVVHTGQTSKEYSIRFNHYPLLTEVWILEGDDRIYYSENPAIAS
                     PFYKNQNPFAFDKAINSASFDHHWGYQGELGCRVEDNQAHFSLWSPTATEVQVVVYES
                     AANDAPVWKTFEMKRGNSYSYNHKDNTIGVWSLDVEEDLVGKAYQYQVQFPHHQTLTR
                     DPYTIATSPDGKRSAILSHVEKQVENFEVKHGSEATWRLENPCKAVICEMHIRDLTKS
                     PTSGVDEHLRGTFLGAAQAGTVNQYGQSTAFDYIKKLGYNYVQLQPIADRHKEYDEDG
                     NVTYNWGYDPQNYNAPETSFSTNPDDPAQVIRDLKVMVQAYHDAGIGVIMDVVYNHTF
                     SVVDAPFQTTVPDYYYRMNPDGTFQNGTGVGNETASEHEMFRKYMIDSLLYWVQEYNI
                     DGFRFDLMGIHDVKTMQMIRQSLDEIDSNIILYGEGWDMGTGLAPYDKAKKDNAYQMP
                     NIGFFNDNQRDAVKGGEVYGAIKSGFVSGAATEPILAKAILGSRELGSYTHPNQVLNY
                     VEAHDNYNLHDLLATLHPDQSSEQIMRKVETATAMNLLMQGMAFMEIGQEFGRTKLVA
                     TGENGELTHDDRERAMNSYNAPDSVNQVNWNLINERQDSIEFIRQVIRLKTKTGAFSY
                     SSYDEIYHHVFVHSAIEHSGYLIYEVHGKEHLLVVVNAKSEPYQFENAGNLAMLVTNS
                     RSKEDNVLNDISLAVLSVL"
     gene            complement(4481..6439)
                     /gene="ligA"
                     /locus_tag="VXE25_001816"
     CDS             complement(4481..6439)
                     /gene="ligA"
                     /locus_tag="VXE25_001816"
                     /EC_number="6.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001042597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-dependent DNA ligase LigA"
                     /protein_id="HEV0772234.1"
                     /translation="MNKRMNELVALLNRYATEYYTSDNPSVSDSEYDRLYRELVELET
                     AYPEQVLADSPTHRVGGKVLDGFEKYSHQYPLYSLQDAFSREELDAFDARVRKEVAHP
                     TYICELKIDGLSISLTYEKGILVAGVTRGDGSIGENITENLKRVKDIPLTLPEELDIT
                     VRGECYMPRASFDQVNQVRQENGEPEFANPRNAAAGTLRQLDTAVVAKRSLATFLYQE
                     ASPSTRDSQEKGLKYLEQLGFVVNPKRILAENIDEIWNFIQEVGQERENLPYDIDGVV
                     IKVNDLASQEELGFTVKAPKWAVAYKFPAEEKEAQLLSVDWTVGRTGVVTPTANLTPV
                     QLAGTTVSRATLHNVDYIAEKDIRKDDTVIVYKAGDIIPAVLRVVESKRVSEEKLDIP
                     TNCPSCNSDLLHFEDEVALRCINPRCPAQIMEGLIHFASRDAMNITGLGPSIVEKLFA
                     ANLVKDVADIYRLQEEDFLLLEGVKEKSAAKLYQAIQASKENSAEKLLFGLGIRHVGS
                     KASQLLLQYFHSIENLSQADSEEVASIESLGGVIAKSLQTYFATEGSEILLRELKETG
                     VNLDYKGQTVVADAALSGLTVVLTGKLERLKRSEAKSKLESLGAKVTGSVSKKTDLVV
                     VGADAGSKLQKAQELGIQVRDEAWLESL"
     gene            complement(6532..7710)
                     /locus_tag="VXE25_001817"
     CDS             complement(6532..7710)
                     /locus_tag="VXE25_001817"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001083019.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEV0772235.1"
                     /translation="MNRYAVQLISRGAINKMGNMLYDYGNSVCLASMGTIGQTVLGMY
                     QISELVTSILVNPFGGVISDRFSRRKILMTADLVCGILCLAISFIRNDSWMIGALIVA
                     NIVQAIAFAFSRTANKAIITEVVEKDEIVIYNSRLELVLQVVGVSSPVLSFLVLQFAS
                     LHMTLLLDSLTFFIAFVLVAFFPKEEAKVQEKKAFTGRDIFVDIKDGLHYIWHQQEIF
                     FLLLVASSVNFFFAAFEFLLPFSNQLYGSEGAYASILTMGAIGSIIGALLASKIKANI
                     YNLLILLALTGVGVFMMGLPLPTFLSLSGNLVCELFMTIFNIHFFTQVQTKVESEFLG
                     RVLSTIFTLAILFMPIAKGFMTVLPSVHLSSFLIIGSGVIILSCISFIYVRTHFEKLI
                     "
     gene            complement(7790..8653)
                     /locus_tag="VXE25_001818"
     CDS             complement(7790..8653)
                     /locus_tag="VXE25_001818"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012291596.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE/MutR family transcriptional regulator"
                     /protein_id="HEV0772236.1"
                     /translation="MEHLGKVFREFRTSGNYSLKEAAGESCSTSQLSRFELGESDLAV
                     SRFFEILDNIHVTIENFMDKARNFHNHEHVSMMAQIIPLYYSNDIAGFQKLQREQLEK
                     SKSSTTSLYFELNWILLQGLICQRDASYDMKQDDLDKVADYLFKTEEWTMYELILFGN
                     LYSFYDVDYVTRIGREVMEREEFYQEISRHKRLVLILALNCYQHCLEHSSFYNANYFE
                     AYTEKIIDKGIKLYERNVFHYLKGFALYQKGQCKEGCKQMQEAIHIFDVLGLPEQVAY
                     YQEHYEKFVKS"
     gene            complement(8656..10557)
                     /locus_tag="VXE25_001819"
     CDS             complement(8656..10557)
                     /locus_tag="VXE25_001819"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000584877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HEV0772237.1"
                     /translation="MIILQANKIERSFAGEVLFDNINLQVDERDRIALVGKNGAGKST
                     LLKILVEEEEPTSGEINKKKDISLSYLAQDSRFESENTIYDEMLHVFDDLRRTDKQLR
                     QMELEMGEKSGDELDKLMSDYDHLSENFRQAGGFTYEADIRAILNGFKFDESMWQMKI
                     AELSGGQNTRLALAKMLLEKPNLLVLDEPTNHLDIETISWLENYLVNYSGALIIVSHD
                     RYFLDKVATITLDLTKHSLDRYVGNYSRFVELKEQKLATEAKNYEKQQKEIAALEDFV
                     NRNLVRASTTKRAQSRRKQLEKMERLDKPEAGKKAANMTFQSEKTSGNVVLTVENAAV
                     GYDGEVLSQPINLDLRKMNAVAIVGPNGIGKSTFIKSIVDQIPFIKGEKRFGANVEVG
                     YYDQTQSKLTPSNTVLDELWNDFKLTPEVEIRNRLGAFLFSGDDVKKSVGMLSGGEKA
                     RLLLAKLSMENNNFLILDEPTNHLDIDSKEVLENALIDFDGTLLFVSHDRYFINRVAT
                     HVLELSENGSTLYLGDYDYYVEKKATAEMSQTEEASTSNQAKEASPVNDYQAQKESQK
                     EVRKLMRQIESLEAEIEELESQSQAISEQMLETNDADKLMELQAELDKISHRQEEAML
                     EWEELSDQV"
BASE COUNT         3187 a         2349 c         1911 g         3192 t
ORIGIN      
        1 gagctgtact attctagttt caatatacta tagtaccaaa aagttcgtat tttttctata
       61 attattatta ttttatagca aaaaaataaa accaggaaaa caatttcctg gttttacacg
      121 ttatttcaca tcaaaaacaa tggatttgac atttgtcatc gcttcaatgc tatatttaat
      181 tccttgcact ccagctccag aacctttgac accaaggaat gggaaattat ctggaccacg
      241 ctgggtttta ttattaatgt ggactgtacc tacttcaagt ttttcagcaa tttcaaaggc
      301 ttttttgaaa tcatttgtaa agactgatga ttgaaggccg aattcagatt cgttggcaaa
      361 ggcaatagct tcctctacac tagccacacg aatgattggt aaaacaggac caaatggctc
      421 ttcccatgcc actttcatat cttttgtaac ttggtcaaaa agcactggcc agaggagatt
      481 gccctcacgt ttgattggtg taagagcctg agcctctttt tcttgtgcat cctcaatcaa
      541 gccccaaatg aagtcggctg aagcattatc aataacaggt gtaatatcag cattgtcaaa
      601 tggatcacca actgttaatt tagaaacttc ttcctgaagc aaagtagcta atttatctgc
      661 tacactttcg agaacaatga cacgtttaat ggccgtgcaa cgttgtcctg agtagctaaa
      721 ggctcccgca acaatttgct tggcagcatg ttccaaatct gcatcttcta gtacaagagc
      781 tgcatctttc ccaccaagtt ccaacatgat aggacgcata ccagctaaac gaccaatacg
      841 ttctccaata ggagttgaac ctgtaaagtt gatgaagttg acttctttgt gctcaatgat
      901 ataatcccca atttctgaac cacgacctgt aatggtgttg aaaacacctg ccggaatccc
      961 tgcttcttca aatgctttag ccaacaagag tccagaaatg gaaccttgtg ttggtggctt
     1021 aaacatgacc acattccctg caatcaaggc aggtgcaatt ttagaagcag ataaattaac
     1081 tggataatta aagggagcaa tcgctagcac gataccaact ggttcacgac ggacaacagc
     1141 cagtttgttt ttacttgctg cctcaaaacc accaccttcc attgcttgtc cagtgatacg
     1201 gagaccttcc tcagcagcat aacgaatcaa gtctgctgta cgcactactt ctccaattgc
     1261 tgctttaatc ccttttgcta cttctttggc aaggatagta ccaatttctt ccttatcgcg
     1321 ttctaaaata gctgctgttt tatgtaaata agccgcacgt tcaactgctg ataaagctcg
     1381 ccatgctggc agggctgcac gcgcagcttg catagcctca tcagcttcag tctgagtcat
     1441 ggctggaact gtacccaatt cttcttgatt gattggtgaa taaatcgtaa tttcttgttc
     1501 agatgatttc cattttccat ttactaaatt ctgatatctt gtcaaattct tgtcctcctg
     1561 aaaatgatta agatatattt taccaaattt tcagaaaatc acaacccttt ttgcaaaatt
     1621 tttgagatta ttttcacaaa cttgattttt caaagtatac tcaataaaaa taaaaaaaat
     1681 ccactacgtc aaggcgaggc taatgtggtt tgaagaaatt ttcgaagagc gtgaatgagt
     1741 atcatctata gtaaaataaa aaaactgaac aatttggttg gggacagcca aaccaatttc
     1801 tcacaatgtt tcagaaacaa gggtgtgcta ctccaatttc agcctactat aactgtcata
     1861 gattgctgaa acaaagtcta ggtaaaagtc ttcataataa aaagacctcc tatcaagtgt
     1921 tcaaaaactt tgataggagg tcttgttttg tgaaaatatt tatcaaattt tctatacaag
     1981 tgagctgtta gccaggttct ttctattctt tcaatttcaa tgaatggatt ttttactaat
     2041 actcataact gggaatttgt ctgtgtaaaa atagcgagat agatggtatt tataaaacac
     2101 tcaagacagc tagactaata tcatttaaaa cattatcttc ttttgagcga ctgttggtta
     2161 ccaacatagc taaatttcct gcattttcaa attgataggg ttctgattta gcattcacaa
     2221 ccaccaagag gtgttctttg ccgtgaactt catagataag gtagccgcta tgttcaatcg
     2281 cagaatgcac aaagacatga tggtaaattt catcatagct agagtaagaa aaggcaccag
     2341 tttttgtctt caatcggatg acttgacgga taaactcaat actgtcttga cgctcattaa
     2401 tcaagttcca gttcacttgg ttcacactgt caggagcatt atagctattc atcgcacgct
     2461 ctctatcatc atgggtcaac tcaccatttt caccagtcgc aaccagtttg gtacgaccaa
     2521 attcttgacc gatttccata aaggccatcc cctgcatgag cagattcatg gctgtggcag
     2581 tttcgacctt gcgcatgatt tgctctgaac tttggtctgg atgaagggtt gccaataaat
     2641 cgtgaagatt gtaattgtca tgggcttcta catagttaag cacctgattt ggatgtgtat
     2701 agcttcctaa ttcacgactt cctaggattg ctttagctag aattggctct gtcgcagcac
     2761 cactgacaaa acctgacttg atagcaccat aaacttctcc ccctttgaca gcatcgcgct
     2821 gattgtcatt aaagaaacca atatttggca tctggtaggc attgtccttc ttggccttat
     2881 cataaggggc aagacctgtt cccatatccc atccttctcc atagaggata atgttggagt
     2941 cgatttcatc caagctttga cgaatcatct gcatggtctt gacatcatga atccccatca
     3001 agtcaaaacg gaagccgtca atattatatt cctgcaccca gtatagaaga gaatcaatca
     3061 tatacttgcg aaacatttcg tgttcactgg ctgtttcatt tccaacaccc gttccattct
     3121 ggaaggtacc atctggattc atacgataat agtaatcagg gactgttgtt tggaatggtg
     3181 catcaacaac tgagaaggta tggttataga ctacatccat aatgactcca atacccgcat
     3241 cgtgataagc ttgaaccatc accttcaaat cacgaatgac ctgagctgga tcatctggat
     3301 tagttgaaaa actagtttct ggcgcgttat agttttgtgg atcataaccc cagttgtagg
     3361 ttacatttcc atcctcatcg tattctttat gacggtctgc aattggttgc aattgaacat
     3421 aattgtagcc cagcttcttg atgtaatcaa aagcagttga ctggccgtat tggttaactg
     3481 ttccagcctg agcagcaccc aagaaagttc ctcgaagatg ttcatctaca cccgatgtag
     3541 gtgatttagt caaatcacga atatgcattt cacagataac tgccttacat ggattttcca
     3601 agcgccaagt agcctccgaa ccgtgcttaa cctcgaagtt ttcaacttgc ttttctacat
     3661 ggctcagaat agctgaacgt ttgccatcag ggctggtcgc gattgtataa ggatcacgtg
     3721 tcagtgtttg gtgatgaggg aattggactt gatactgata agccttacct accaaatctt
     3781 cctcaacatc caaactccag acaccgattg tattgtcctt atgattataa gagtagctat
     3841 tgcctctttt catctcaaaa gtcttccaaa cgggtgcatc attagcagct gattcataaa
     3901 cgacaacttg cacttctgtc gctgtaggtg accagaggga aaaatgagcc tgattgtcct
     3961 ctacacggca acccaattct ccttggtaac cccaatgatg gtcaaaacta gcactgttaa
     4021 tggccttatc aaaggcaaaa ggattttgat ttttatagaa aggactggca atagcaggat
     4081 tttcagagta ataaatccta tcatcgcctt ccaaaatcca gacctctgtt aataggggat
     4141 agtgattaaa acggatagaa tattctttac tagtttgacc tgtatgaacc acaaaattca
     4201 agctttctat aacatgtgaa cttgggtgtt caaagctaaa taaagctcca aaataatctt
     4261 ctttgtaggt tagcaaatca attcgttgat cctgactttt tacaaaggag caagtgtcat
     4321 attctccatt cttacgatgg taatgaatgc gcatagggta gttatacatt ttttattttt
     4381 cctttttact ttgtttctat ttcactaata aatttttgtc aatctcgtct caattaacag
     4441 acatagtcat attctctaaa ctctgttttt aaacgatcca ttacaaactt tctagccatg
     4501 cctcatctct gacctggata ccaagttctt gtgctttttg cagtttactt ccagcgtctg
     4561 cacctaccac gacgaggtcg gtctttttag aaacactacc tgtcactttg gcacccagac
     4621 tttcgagttt acttttagct tctgagcgct tgagtcgttc caattttcct gtcaatacca
     4681 cggtcaaacc tgacaaggcc gcatccgcta ctaccgtctg tcctttatag tccagattga
     4741 ccccagtttc tttcaattct ctgagcagaa tttcagagcc ttctgtcgca aaataagtct
     4801 gaagactttt ggcaatcacg ccacctagac tttcaatact agccacttcc tctgaatctg
     4861 cctgagacag attttcaatt gaatggaaat attgaagtaa aagctgacta gccttgcttc
     4921 cgacatgacg aattcccaaa ccaaataaga gcttctcggc agaattttcc tttgatgctt
     4981 ggatagcctg atacagttta gcagcggact tttccttaac cccctctaaa aggaggaaat
     5041 cctcttcttg caaacgataa atatccgcca catccttgac taaattagca gcaaaaagct
     5101 tctcaacaat agatggacca aggcctgtaa tattcatagc atcacgagaa gcaaagtgaa
     5161 tcaagccttc catgatttga gcagggcaac gcggattgat acaacgtagg gccacttcat
     5221 cttcaaagtg caacaagtca gagttacaac ttggacagtt tgtagggata tctagttttt
     5281 cttcagaaac ccgtttggac tctaccacac gtaaaacggc agggatgatg tcaccagcct
     5341 tatatacaat gaccgtatcg tcttttcgga tatctttttc agcaatataa tctacattgt
     5401 gcagggtcgc acggctaaca gtcgtaccgg caagttgtac tggtgttaga ttagcagttg
     5461 gagttacaac accggtacgg ccaactgtcc agtcaactga taagagttga gcttcttttt
     5521 cttcggcagg gaacttgtag gctactgccc actttggagc cttaactgta aaaccaagtt
     5581 cttcttgact tgctaggtcg ttgaccttga ttaccactcc atcaatatcg taaggcagat
     5641 tttcccgttc ctgtcctact tcttggataa aattccagat ttcatctatg ttttcagcca
     5701 agattcgctt aggattgacc acaaaaccta gttgttctag gtacttcaaa cccttttctt
     5761 ggctatcacg agttgaaggg ctggcttctt gatagagaaa cgttgcaaga ctacgcttgg
     5821 caactactgc tgtatccaac tgacgcagag ttcctgctgc cgcattacga ggattagcaa
     5881 attcaggctc tccattttct tggcgcactt ggttaacttg gtcaaaggaa gcgcgtggca
     5941 tgtaacattc cccacgaact gtgatatcta gttcttctgg caaagtcaaa gggatgtcct
     6001 taacacgctt gaggttttct gtgatatttt caccaattga accatctcca cgtgttaccc
     6061 cagcaaccaa aatccccttt tcataagtca gcgagataga taagccatcg attttcagct
     6121 cacaaatata ggtcggatga gccacttcct tacgaacacg cgcatcaaaa gcatctagct
     6181 cctcacgtga aaaagcatcc tgcaaactat aaagaggata ctgatgactg tatttttcaa
     6241 aaccatctaa aaccttgcca ccaacacgat gagtcggact gtctgctagc acttgctctg
     6301 gataagcagt ttctaactcg accaactcac ggtaaaggcg gtcatactca ctgtctgaaa
     6361 ccgagggatt atcgctggta tagtactcag tcgcatagcg attgagcaaa gcgactaact
     6421 cattcattct tttattcata agaccatttt accataaaac aagccctcct cacaaacgag
     6481 aagggcggaa aaaacactta gtttgaaatt atttttgaaa ctcaagcaac cttatatcaa
     6541 tttttcaaaa tgagttcgaa cataaataaa cgatatacaa gacaagatga taacaccact
     6601 tccaattatc aggaaagaag agagatgtac acttggcaag actgtcataa atccttttgc
     6661 aataggcata aatagaatag ctaaggtaaa aattgtactc agtactctcc caagaaattc
     6721 gctctcaacc ttggtttgta cttgagtaaa aaagtgaata ttaaaaatcg tcataaacaa
     6781 ttcacaaact aaatttccag aaagggaaag aaaagttgga agtggtaatc ccatcataaa
     6841 aactccgaca cctgtcaaag ccagtaaaat caaaagatta taaatattag ctttaatttt
     6901 actagctaga agagccccaa tgatggaacc aatagccccc atagttaaaa tacttgcata
     6961 ggctccttct gacccgtaaa gctgattcga aaagggaagt agaaattcaa aagctgcaaa
     7021 aaagaaatta acgctggaag ctaccagcaa aaggaagaaa atttcttgct gatgccagat
     7081 atagtgtaac ccatccttga tatctacaaa aatatctctc ccagtaaaag cctttttctc
     7141 ttgaactttt gcttcctctt ttggaaagaa agccactaga acaaaagcaa tgaaaaaagt
     7201 cagcgagtct agcagtagcg tcatatggag acttgcaaac tgtaaaacaa ggaaggaaag
     7261 aacaggagag ctaacaccta caacctgcaa aaccagctct aggcgagaat tatagatcac
     7321 aatctcatct ttctccacca cttcagttat gatagcttta ttggctgtgc gagaaaaggc
     7381 aaaagcaata gcctgcacaa tgttagcaac aatcaaagcg ccaatcatcc agctatcatt
     7441 ccttatgaaa gaaatagcca gacaaagaat cccacaaaca agatctgccg tcattaaaat
     7501 cttacgacga gaaaaacggt ctgaaataac tccgccaaag ggattgacga gaatagatgt
     7561 gacgagctca gaaatctgat acattcctaa aactgtctgt cctatagtcc ccatagaagc
     7621 caagcagaca ctatttccat aatcatagag catatttccc attttattga tagccccacg
     7681 gctaatcaac tgcactgcat agcgattcat attaaagctc ctctcaaatt ttgaaactat
     7741 tgtatcaaaa ccgaaaggag ctttttattt tttcccttat ttgggaaaat taacttttga
     7801 caaatttttc gtagtgttcc tgataatagg ctacttgctc tggaagacct aacacatcaa
     7861 aaatatgtat ggcctcttgc atctgcttac agccttcttt acactgtcct ttttgatata
     7921 aggcaaaacc ttttaaataa tggaaaacat tacgctcata aagcttaata cctttgtcaa
     7981 taatcttctc tgtataagcc tcaaaatagt tggcattata aaaagaagaa tgctctaaac
     8041 aatgctggta acaattgagg gccaaaatca acactaatct cttatggcga ctaatctctt
     8101 ggtaaaattc ctccctctcc ataacttctc taccaatccg agtgacatag tctacatcgt
     8161 agaaactata gaggttaccg aaaagaatca actcatacat ggtccattct tctgttttga
     8221 agagataatc tgctacctta tccaaatcat cctgcttcat atcataactc gcatctcttt
     8281 gacaaatcag accttgtagc aaaatccagt tcagctcaaa ataaagggaa gtcgtcgaac
     8341 tcttagactt ttcaagttgt tctctttgaa gcttttgaaa acctgcaata tcgtttgaat
     8401 agtaaagtgg gataatctgt gccatcatag acacatgttc atgattatga aaattccttg
     8461 ccttatccat gaaattttcg attgttacat gaatgttatc caaaatctca aagaaacggg
     8521 agactgccag gtcagactcc ccaagctcaa agcgagataa ctgagaggta gagcaggatt
     8581 cgcctgctgc ttcctttaaa gaataatttc cacttgttcg aaattcacga aatacttttc
     8641 caagatgttc catctttaca cctgatctga taattcttcc cactcaagca tagcttcttc
     8701 ctgacgatgg ctgattttgt ccagctcagc ctgtaattcc atgagtttgt cggcatcgtt
     8761 tgtttccaac atttgttcag aaatggcttg gctttgactt tctagctctt caatttcagc
     8821 ttctagactt tcgatttgtc gcatgagttt gcgaacttct ttttgacttt ctttctgggc
     8881 ctgatagtca ttgactggac ttgcttcctt tgcttgattg ctagttgaag cttcctcagt
     8941 ctgactcatt tctgctgttg ctttcttctc aacatagtag tcgtaatctc caaggtagag
     9001 agttgaacca ttctcagaca attccaaaac atgagttgcc acacgattga taaagtaacg
     9061 atcatgactg acaaaaagca aggtaccatc aaagtcaatc aaggcatttt ctagcacttc
     9121 cttactatca atatccaagt ggttggtcgg ctcatccaga atcaaaaagt tattgttttc
     9181 catagacaat ttagctaaaa gcaaacgagc tttttcgcca ccagatagca tgccgactga
     9241 ttttttaaca tcatctcctg agaaaaggaa ggctccaaga cggttgcgga tttcaacttc
     9301 tggtgtcagt ttgaaatcat tccagagttc atccagcacc gtattacttg gtgtcagctt
     9361 gctttgggtt tggtcatagt aaccaacctc aacattagcg ccaaagcgct tttctccctt
     9421 gataaacgga atttgatcca cgattgattt gataaaggtt gattttccga taccattggg
     9481 accaacgata gcaacagcat tcatcttacg aaggtctagg ttaatcggtt gtgacaggac
     9541 ttccccatca tagccaacag ccgcattttc aacagtcaaa acaacattgc ccgacgtttt
     9601 ttcagactgg aaggtcatgt tggctgcttt cttgccagct tccggcttgt ccaaacgctc
     9661 cattttttct agttgtttac ggcgagattg agcacgtttg gtcgttgaag cacgaactag
     9721 attgcgattg acaaagtctt ccagagcagc gatttccttc tgttgctttt catagttttt
     9781 tgcctcagta gctagctttt gctccttcaa ctcgacaaaa cgagagtaat tccccacata
     9841 gcgatccaag gaatgcttgg tcaaatctag cgtaattgtc gcaaccttgt ccaagaaata
     9901 acggtcgtgg ctgacgataa tgagggcacc gctatagttt accaagtaat tctctagcca
     9961 ggagatggtt tcaatatcca agtggttagt tggctcgtcc aagaccaaga gattgggctt
    10021 ttcaaggagc attttagcta gagccaaacg agtattttga ccacctgaaa gttcagctat
    10081 tttcatctgc cacatagact cgtcaaactt gaatccattc aaaatcgctc gaatatcagc
    10141 ttcataggta aagccgcctg cttggcgaaa attctcagat aagtggtcgt aatctgacat
    10201 cagtttatcc aattcatcgc cagacttttc acccatctcc aactccatct gacgaagttg
    10261 tttatctgtc cgacgtaagt catcaaagac atgaagcatt tcatcgtaga tggtattttc
    10321 agactcaaaa cggctatctt gggctaggta agacagagaa atatcttttt tcttattgat
    10381 ttctccgcta gttggctcct cttcttcaac taaaatcttc aaaagagtag acttacctgc
    10441 accatttttc ccaacaagag caatccgatc tcgttcatca acctgcaggt tgatattatc
    10501 gaaaagaacc tctcctgcaa aagaacgttc aattttatta gcttgtaaaa taatcataag
    10561 agtagtatag catgtttccc taaggcattc aagataatcg taagtctttt agtacaactt
    10621 ttataacata aaataaact
//
LOCUS       DAVLHC010000059        10629 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.060, whole genome shotgun sequence.
ACCESSION   DAVLHC010000059 DAVLHC010000000
VERSION     DAVLHC010000059.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10629)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10629)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10629
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.060"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            209..1084
                     /locus_tag="VXE25_001820"
     CDS             209..1084
                     /locus_tag="VXE25_001820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001153874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
                     /protein_id="HEV0772238.1"
                     /translation="MQDNYTTKGKHLTIDSRRLIERWKKEGKSNREIASLLGKAPQTI
                     HTKIKRRTVRKCLGKGRFKEVYSADYAQQSYENNRKHSVKRSSVTKELKEKILHYHNQ
                     KFSPDKKQASTNFKPAGQSIEQRLEAINFRLENGHYEIDTVLLTRAKNYCLLVLTDRK
                     SRHQIIRLIPNKSADVVNQALKLILKQHKILSITADNGTEFNRLSNVFSEKHIYYAHP
                     YASWERGTNENHNRLIRRWLPKGTKKMTPKEVAFIEKWINNYPKKCLDYKSPREDFLM
                     ANLNLKFSVRNKSRN"
     gene            1110..1754
                     /locus_tag="VXE25_001821"
     CDS             1110..1754
                     /locus_tag="VXE25_001821"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000234620.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VIT family protein"
                     /protein_id="HEV0772239.1"
                     /translation="MLRAGVLDANDGIISIAGVVIGVASATTNIWIIFLSGFTAILAG
                     AFSMAGGEYVSVSTPKDTEEAAVSREKLLLDQDRELAKKSLYAAYIQNGEFKTSAQLL
                     TNKIFLKNPLKALVEEKYGIEYEEFTNPWHAAISSFVAFFLRSLPPMLSVTIFPSDYR
                     IPATVLIVGVALLLTGYTSARLGKAPTKTAMIRNLAIGLLTMGVTFLLGQLFSI"
     gene            complement(1796..3784)
                     /locus_tag="VXE25_001822"
     CDS             complement(1796..3784)
                     /locus_tag="VXE25_001822"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000489335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEV0772240.1"
                     /translation="MFRLTNKLAVSNLIKNRKLYYPFALAVLLAVTVTYLFYSLTFNP
                     KIAEIRGGTTIQATLGFGMFVVTLASAIIVLYANSFVMKNRSKELGIYGMLGLEKRHL
                     ISMTFKELVVFGILTVGAGIGIGALFDKLIFAFLLKLMKLKVELVATFQMNVVIAVLV
                     VFGLIFLGLMFLNALRIARMNALQLSREKASGEKRGRFLPLQTILGSISLGIGYYLAL
                     TVTDPLTALTTFFLAVLLVIFGTYLLFNAGITVFLQILKKNKKYYYQPNNLISVSNLI
                     FRMKKNAVGLATIAILSTMVLVTMSAATSIFNSAESFKKVLNPHDFGVSGQNVEKEDL
                     DKLLSQFASDKGYSVKEKEVLRYSNFGIANQEGTKLTIFEKGQNRVQPTTVFMVFDQK
                     DYENMTGQKLSLSGNEVGLFAKNDGLKGQKALTLNDHQFSVKEEFNKDFIVNHVPNKF
                     NILTTDYNYLVVPDLQAFLDQFPDSAIYNQFYGGMNVNVSEEEQLKVAEEYENYLNQF
                     NAQLDTEGSYVYGSNLADASSQMSALFGGVFFIGIFLSIIFMVGTVLVIYYKQISEGY
                     EDRERFIILQKVGLDQKQIKQTINKQVLTVFFLPLLFAFIHLAFAYHMLSLILKVIGV
                     LDTTMMLIVTLSICAIFLIAYVLIFMITSRSYRKIVQM"
     gene            complement(3786..4544)
                     /locus_tag="VXE25_001823"
     CDS             complement(3786..4544)
                     /locus_tag="VXE25_001823"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000173375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0772241.1"
                     /translation="MTLLDVKHVQKIYKTRFQGNQVEALKDIHFTVEKGDYVAIMGES
                     GSGKSTLLNILAMLDKPSRGQVYLNGTDTATIKNSQASSFRREKLGFVFQDFNLLDTL
                     SVKDNILLPLVLSRRPITEMMKKLVVTAENLGINQLQEKYPYEISGGQKQRVAVARAI
                     ITEPEILLADEPTGALDSKSSAALLDVFDEINERGQTILMVTHSTAAASRAKRVLFIK
                     DGILYNQIYRGEKTERQMFQEISDTLTVMASEVN"
     gene            4972..5163
                     /locus_tag="VXE25_001824"
     CDS             4972..5163
                     /locus_tag="VXE25_001824"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000680763.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772242.1"
                     /translation="MKHKEHILIGLLYLLSPFIGQLLVEHTHFISTEFTGTAYVICWL
                     SVVISIHHFSKNVLSQQQK"
     gene            complement(5517..5789)
                     /locus_tag="VXE25_001825"
     CDS             complement(5517..5789)
                     /locus_tag="VXE25_001825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PspC domain-containing protein"
                     /protein_id="HEV0772243.1"
                     /translation="MNSKFYKMRRNRMISGVLAGLSDKWNFDVTLVRFLFAIFTVANF
                     GLGVIIYIILASIMPTKEEIEAEMYGTGPRKRKEAQAIDDNEGWFW"
     gene            complement(5848..6297)
                     /locus_tag="VXE25_001826"
     CDS             complement(5848..6297)
                     /locus_tag="VXE25_001826"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000778579.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SprT family protein"
                     /protein_id="HEV0772244.1"
                     /translation="MKLTDYVKQVSLEDFGRPFIHHVQWNRRLRSTGGRFFPKDGHLD
                     FNPKVYQELGLDVFRKIVRHELCHYHLYFQGKGYQHKDRDFKELLKAVDGLRFVPSLP
                     NSNSKPIKLYRCQSCQQTYQRKRRIDTKRYRCGLCRGKLLLVNQPED"
     gene            complement(6284..8413)
                     /locus_tag="VXE25_001827"
     CDS             complement(6284..8413)
                     /locus_tag="VXE25_001827"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000359105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding transcriptional accessory protein"
                     /protein_id="HEV0772245.1"
                     /translation="MDKKYEKISQDLGVTLKQIDTVLSLTAEGATIPFIARYRKDMTG
                     SLDEVAIKAIIDLDKSLTNLNDRKEAVLAKIQEQGKLTKELEEAILVAEKLADVEELY
                     LPYKEKRRTKATIAREAGLFPLARLILQNIVDLEKEAEKFVCEGFATGKEALTGAVDI
                     LVEALSEDVTLRSMTYQEVLRHSKLTSQAKDESLDEKQVFQIYYDFSETVGTMQGYRT
                     LALNRGEKLGVLKIGFEHATDRILAFFVTRFKVKNAYIDEVVQQSVKKKVLPAIERRI
                     RTELTEKAEEGAIQLFSDNLRNLLLVAPLKGRVVLGFDPAFRTGAKLAVVDATGKMLT
                     TQVIYPVKPASARQIEEAKKDLADLIGQYGVEIIAIGNGTASRESEAFVAEVLKDFPE
                     VSYVIVNESGASVYSASELARQEFPDLTVEKRSAISIARRLQDPLAELVKIDPKSIGV
                     GQYQHDVSQKKLSESLDFVVDTVVNQVGVNVNTASPALLSHVAGLNKTISENIVKYRE
                     EEGKITSRSQIKKVPRLGAKAFEQAAGFLRIPESSNILDNTGVHPENYAAVKELFKCL
                     DIKDLNEEAQSKLKSLSVKEMAQELDLGPETLKDIIADLLKPGRDFRDSFDAPVLRQD
                     VLDIKDLVVGQKLEGVVRNVVDFGAFVDIGIHEDGLIHISHMSRKFIKHPSQVVAVGD
                     LVSVWVKKIDTEREKVNLSLLAPNETD"
     gene            8457..8540
                     /locus_tag="VXE25_001828"
                     /pseudo
     CDS             8457..8540
                     /locus_tag="VXE25_001828"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            8870..9775
                     /locus_tag="VXE25_001829"
     CDS             8870..9775
                     /locus_tag="VXE25_001829"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="permease"
                     /protein_id="HEV0772246.1"
                     /translation="MTAFQQLPSSVLQTGAIFLSIIIEALPFVLIGSIVSGLIEVYIT
                     PDKVYHFLPRNRWGRIFFGTFVGILFPSCECGIVPIINRFLEKKVPSYTAVPFLVTAP
                     VINPIVLFATYSAFGNSFHVALLRALGSILVAVILGIFLGFFWQEPIQKENRLACHEH
                     DFSYLSSAKKVFQVFVQAIDEFFDTGRYLVFGCLFASIIQVYVPTRILTSISATPLFA
                     ILLLMLLAFLLSLCSEADAFIGASLLSSFGLAPVLAFLVIGPMLDIKNILMMKNYLKA
                     RFISHFITIVTLVVLAYSLLIGVIL"
     gene            9772..10587
                     /locus_tag="VXE25_001830"
     CDS             9772..10587
                     /locus_tag="VXE25_001830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000617844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR03943 family protein"
                     /protein_id="HEV0772247.1"
                     /translation="MIRFLVLAGYFELTIYLHLSGKLNQYINMHYSYLAYISMVLSFI
                     LAIVQLYIWMKQVKTHSHLNSRLAKMTSISLLAIPLVIGLTFPTVSLDSQTVSAKGYH
                     FPLSEGTDLAIQTSEGTTSQYLKPDTSSYFSKSAYEKEMRTAADKYLSQDSIQITNEN
                     YMEVMEAIYDYPDEFEGKTIQFTGFVYNDPSHANSQFLFRFGIIHCIADSGVYGLLTK
                     GNTRQYENNTWISAKGKLVNHYHKELKQNLPTLEIDSFTKVDKPENPYVYRAF"
BASE COUNT         3178 a         2254 c         2044 g         3153 t
ORIGIN      
        1 ttagaaatag attttactgt cctgatcgat ttgttctgtt cttgtttcat tttactatat
       61 gttcgtaaat gaaagttcta taatgaagtt agccacccag ccctcctaaa aattagatgg
      121 ttcaactagc tgatagctct tgtaggcata agaaaacacc tctgtgttat acttgttgtt
      181 caaccacaaa cacaagaaag gcacagaaat gcaagacaat tatactacaa aaggtaaaca
      241 tttgacaatc gatagccgtc gcttaatcga aagatggaaa aaagaaggaa aatcaaatag
      301 agaaattgcc tctctacttg gaaaagctcc tcaaactatc cacactaaaa tcaagcgtag
      361 gacagtccga aaatgtcttg gaaaagggcg cttcaaagag gtttattctg ccgactatgc
      421 tcaacagtct tatgaaaata atcgcaagca ctcggtcaag agatcaagcg tgaccaagga
      481 actaaaggaa aagattctcc actatcataa ccaaaaattt tcgcctgata agaaacaggc
      541 cagcaccaac tttaaacctg ctggtcaatc catcgaacag cggcttgaag ctatcaattt
      601 tcgcttggag aatgggcatt atgagattga tacagttcta cttacgagag cgaaaaacta
      661 ctgcttgctt gtcttgacgg atcgaaaaag tagacatcag atcatccgat tgattccaaa
      721 taaaagtgct gatgtggtca atcaggctct aaaactcatc ttaaaacaac acaagattct
      781 ttccatcacg gcagataatg gaacggaatt caatcgcttg tctaatgtat tttctgagaa
      841 gcacatttat tatgcacatc cctatgcctc ttgggaaagg ggaactaatg agaatcacaa
      901 caggctcatt cgtagatggt tacctaaggg aaccaagaaa atgactccca aagaagtcgc
      961 attcatcgaa aagtggatta acaactatcc taaaaaatgc ttggactaca agtcacccag
     1021 agaagacttc ttgatggcta acttgaactt gaaatttagc gtcagaaaca aatcacgaaa
     1081 ttgattcaaa ttttgcaggt cgtttaaata tcctgcgtgc gggtgttctt gatgctaacg
     1141 atggaattat ttccattgct ggtgtggtta tcggagttgc cagtgccacg accaatatct
     1201 ggattatctt tttatcaggt tttacggcta tcttagctgg tgccttttca atggctggtg
     1261 gagaatatgt atccgtttca actccaaaag ataccgagga agctgccgtt tcgcgagaaa
     1321 aactcttgct agaccaagat agggaactag ccaaaaaatc cctctatgct gcttatatcc
     1381 aaaatggaga attcaaaact tctgcccaac tcttgaccaa taagatcttt cttaaaaatc
     1441 cactcaaggc tctggtagag gaaaaatatg ggattgagta tgaagaattt accaatcctt
     1501 ggcacgctgc catttctagc ttcgttgcct ttttccttag aagtttgcct ccaatgctgt
     1561 cagtgaccat ttttccaagt gattaccgca tccctgctac cgtccttatt gtcggtgtgg
     1621 cccttcttct cactggttac acaagtgcta gacttggaaa agccccaacc aaaacagcta
     1681 tgattcggaa ccttgctatt ggtctcttga ccatgggagt taccttcctg ctcggacaac
     1741 ttttcagcat ttagaataca agaaatacct cgattttgaa gtcgaggtat cttttttaca
     1801 tttgcacaat cttgcgataa cttcttgaag taatcatgaa aatcagcaca taggcgatga
     1861 ggaagatagc gcagatagac aaggtcacaa tcaacatcat agtcgtatcc agtacaccaa
     1921 tcacttttaa aatcaggcta agcatatggt aggcaaaggc gagatgtatg aaggcaaaga
     1981 gcaaaggaag gaagaaaaca gttaaaacct gtttgttgat ggtttgcttg atttgctttt
     2041 ggtccaaacc gactttctgc aagataataa agcgttcacg gtcttcgtag ccttcagaaa
     2101 tttgtttgta gtagatgacc agaacagttc cgaccataaa gataatggat aggaaaatac
     2161 cgataaagaa gacaccacca aagagggcac tcatctgaga actagcatct gctagattgc
     2221 taccataaac atagctacct tctgtgtcta attgagcatt aaattgattg aggtagtttt
     2281 catactcctc agcgaccttg agttgttctt cttcactgac atttacattc ataccaccgt
     2341 aaaactgatt atagatagcc gaatctggga attgatccaa aaaggcttgt aaatcaggaa
     2401 caacaaggta attgtaatca gtagtcaaga tattaaactt atttggaaca tggttcacaa
     2461 tgaaatcttt attaaattct tctttgacag aaaattgatg atcatttaga gttagagctt
     2521 tctgtccttt cagtccgtca tttttggcaa agagaccgac ctcatttcct gatagagaca
     2581 gtttttgacc agtcatattt tcataatctt tttggtcaaa taccatgaaa actgttgtgg
     2641 gttggacacg gttttgtcct ttttcaaaaa tagttaactt ggttccttct tgatttgcaa
     2701 taccaaagtt actgtaacga agtacttctt tctctttgac actataacct ttgtcacttg
     2761 caaactggct caagagtttg tccaaatctt ctttttcaac attttgccct gaaaccccaa
     2821 aatcatgagg atttagaact tttttaaagc tttctgcgga attgaaaatg cttgtcgctg
     2881 ctgacatggt taccaaaacc attgttgaca aaatagcgat ggttgctagt ccaaccgcat
     2941 ttttcttcat acggaaaatc aagttggaaa cagatatgag gttattaggt tggtaatagt
     3001 atttcttgtt tttctttaag atttgtagga agactgtaat ccctgcatta aacaatagat
     3061 aagtaccaaa gataaccagc aaaacagcta ggaagaaagt tgttagggct gtaagaggat
     3121 cggttaccgt aagggcaaga taatagccaa tccctaaact tatggaacca agaatagttt
     3181 ggagaggtag gaagcgacct cttttctctc cgcttgcttt ctcacgcgag agctggaggg
     3241 cattcatacg ggcgattcga agagcattca ggaacatgag gcctaggaaa atcaatccaa
     3301 agacaacaag tactgcaatg acaacattca tttggaaggt agcaaccagc tcaaccttca
     3361 gtttcattag tttgagcagg aaagcgaaaa ttaacttgtc aaacaaggct ccaataccga
     3421 tacccgctcc aacagttaga atcccaaata ccactaactc cttaaaggtc atactgatta
     3481 gatggcgctt ctccaagccc aacatgccat aaattcctag ttccttggaa cggttcttca
     3541 tgacaaaact attggcatag agaacgataa tggctgacgc aagggtgacg acaaacatac
     3601 caaatccaag tgtagcctga atggttgttc ctccacggat ttccgcaatc ttgggattga
     3661 aggttagaga gtaaaagaga taggtgacag tgactgccaa gagaacagcc agcgcaaaag
     3721 gatagtagag tttgcggttt ttaatcaagt tcgataccgc taacttattg gttaatcgaa
     3781 acatactaat tcacctcgct tgccatgaca gtcaaggtat cagagatttc ttggaacatc
     3841 tgacgttctg tcttctctcc acggtagatt tgattgtaaa gaatgccgtc cttgataaag
     3901 agaacacgct tggccctgct agcagctgct gttgagtggg ttaccatgag aatggtttgg
     3961 ccgcgctcat tgatttcatc aaagacatca agtaaggctg cagatgactt ggagtcaaga
     4021 gctcctgtcg gttcgtccgc aagaagaatt tcaggttcag tgatgatggc gcgtgctact
     4081 gctacacgct gtttctggcc accagaaatc tcgtaagggt acttctcttg taattggttt
     4141 attcccagat tctcagctgt caccaccaat ttcttcatca tctctgtaat aggtcttctt
     4201 gacaagacaa gcggaagcaa gatattgtcc tttacagata gagtatctag caagttaaag
     4261 tcttggaaga caaagcccaa cttttcacga cggaagctag aggcctgtga atttttaatg
     4321 gttgcggtgt cagttccatt caagtaaacc tgaccacgac ttggtttatc cagcatagct
     4381 agaatattga gaagagttga tttaccagaa ccagactcac ccatgatggc aacgtagtca
     4441 cccttttcga cggtaaagtg aatatccttg agggcctcta cttggttgcc ctgaaaacga
     4501 gttttataaa ttttttgaac gtgttttaca tctaaaagtg tcatgagaat ctcctttctt
     4561 aatatcccat caaatgaaat gtcgcttgca tcatagcgca tcccagctga acgcgctcga
     4621 tttctttgtg acttggtttt cttgttttct tatgtaagat ttgtttcatg atgttactcc
     4681 tttgttcttt atgagtctag tttacatcaa aaaaagacct cttgccataa cctaacctta
     4741 caaaagagac tttaatctta catttttgta agattggggg aaatgtaagc aaaattactt
     4801 agaaaatgat ttgatttcct atttttaaaa ttgtaaaata taaatatgaa aaggcttact
     4861 ttggaaagga ggaagcggga actaacattt tagtaagctt acctagataa cataccattc
     4921 aatttaacac ttgcaagtcg ttcaacctat aaggaaagaa ggtgcgcctt aatgaaacac
     4981 aaagaacata tactcatcgg acttctctat ctgctctctc cattcatcgg tcagctctta
     5041 gttgaacaca cacactttat cagtacagaa tttaccggca ctgcttatgt tatttgctgg
     5101 ttatcagttg ttatcagcat ccaccatttt tccaaaaatg tattgtctca acagcaaaaa
     5161 tagattaaaa aactgcgttt aaattactgc ttttatagta aaatgaaata agaacaggac
     5221 aaatcgatca ggacagtcaa atcgatttct aacaattttt tagaagtata ggtgtcctat
     5281 tctagttcca atccactata gtttgtggat gaagctggcg aaatattatt aatactattc
     5341 aaaaatcaaa gtgcaaacta tatcaacttc acattgccga ctaaattaca gcctgcggct
     5401 ggtttcctag tttgcacttt gatttttatt gagtataaaa gtaaaaaagc tttaaatcaa
     5461 gcagtttaga ctattgattt aaagcttttt gcgtattcca aatcttttgt aaaacctcac
     5521 caaaaccagc cttcattatc gtcaatggct tgagcttctt tgcgtttacg tgggcctgtt
     5581 ccgtacattt ctgcttcgat ttcttccttg gttggcatga tagaagctag gatgatatag
     5641 ataatcaccc caagtccaaa gtttgcgact gtaaaaatgg caaacagaaa acgtacaagg
     5701 gtaacatcaa agttccactt gtctgacaga cctgctaaaa ctcctgaaat catgcgattt
     5761 cgtctcattt tataaaactt actgttcatg atatttcctc tttctgctag gttagacata
     5821 gtatatcacg gataggctcg gctttcatca gtcctcaggc tgatttacta atagcaactt
     5881 tcctcgacaa agtccacagc gatagcgttt ggtatcaatc ctacgcttac gctgataagt
     5941 ttgctggcag gattggcaac gatagagctt gattggcttg gagttactat tgggcaagga
     6001 tggtacaaac cgtaatccat ccactgcttt caacagttcc ttaaaatccc gatccttgtg
     6061 ttgatagcct ttcccttgaa aatagaggtg ataatgacag agttcatgtc ggacaatttt
     6121 cctaaaaacg tccaacccca gttcctgata aaccttggga ttaaaatcca aatgcccatc
     6181 tttggggaaa aatcgcccac ctgtcgaacg tagacgccta ttccactgga catgatggat
     6241 aaaaggtctg ccgaagtctt ctagtgaaac ctgcttgacg taatcagtca gtttcatttg
     6301 gagctaggag agacagatta actttttcac gttcagtatc aattttctta acccaaacgc
     6361 tcaccaaatc tccaactgcc accacttgac tagggtgttt gataaacttg cgactcatat
     6421 gggaaatatg gatgagaccg tcctcatgaa ttccgatatc aacaaaagca ccgaaatcaa
     6481 caacgttacg caccactcct tctagctttt gtccaaccac taagtccttg atatctagga
     6541 catcttgacg gagaactgga gcatcaaagg aatcacggaa atctcgacct ggtttgagaa
     6601 gatctgcaat gatatcttta agagtttctg gaccaaggtc taactcttgc gccatttcct
     6661 tgactgaaag cgacttgagt ttgctttggg cctcttcatt cagatcctta atgtccaagc
     6721 atttgaagag ttccttaacg gcagcgtaat tttctgggtg aactcctgta ttatcaagga
     6781 tattgctact ttcagggata cggaggaaac cagcagcctg ttcaaaagcc ttggccccca
     6841 aacgaggaac tttcttgatt tgggagcgtg aagtgatttt tccctcttcc tcacggtatt
     6901 tgacgatatt ttcagaaatg gttttattga gtccagctac gtgtgaaaga agagctgggc
     6961 tagctgtatt gacattgaca ccaacttggt taaccactgt atcgacaaca aagtccagac
     7021 tctcagatag tttcttctga ctgacatcgt gttggtattg accgacacca attgacttag
     7081 gatcgatttt gaccaattcc gcaagaggat cttgcaaacg acgggcgata gaaatggcag
     7141 agcgtttttc aacggtcaag tctggaaact cctgacgagc aagttcgctg gcagaataga
     7201 cagaagcacc actttcatta acgataacat agctgacttc agggaaatct ttcagaactt
     7261 ccgctacaaa agcttcactt tcacgactgg ccgttccatt tccaatggca ataatctcta
     7321 caccgtattg accaattaaa tctgctaaat ctttcttggc ttcttcgatt tgacgagctg
     7381 atgctggttt aacaggataa ataacctgag ttgtcagcat ttttcctgtt gcatccacga
     7441 cagctagctt ggcacctgta cgaaaggctg ggtcaaaccc aagaaccacg cgccctttca
     7501 gtggagcaac caagaggaga ttgcgcagat tgtcagaaaa aagttggata gctccctctt
     7561 cagctttctc agttaattct gtccgaatac gacgctcaat agcaggcaag acctttttct
     7621 taacggattg ctgaacaact tcatcaatat aagcattttt caccttgaaa cgagtaacaa
     7681 agaaggcaag aatacggtcc gtcgcatgtt caaaaccgat cttcaagaca ccaagtttct
     7741 ccccacgatt gagagccaag gtacgatagc cttgcatagt tccaactgtc tctgaaaaat
     7801 cataataaat ctgaaaaacc tgcttttcat caagactttc atccttggct tgagaagtga
     7861 gtttagagtg tctcagcact tcctgataag tcatagaacg caaggtcaca tcttccgata
     7921 aggcttcgac caaaatatca actgcaccgg tcaaggcttc cttgccagtc gcaaatcctt
     7981 cacagacgaa cttttcagct tctttctcta agtcaactat attctgcaaa atcaagcgag
     8041 caagaggaaa gagtccagct tcacgggcaa tggttgcctt ggtacgacgc ttttccttat
     8101 aaggaagata gagttcttca acgtctgcta atttttcggc aactaagata gcttcttcca
     8161 attccttggt caacttgcct tgctcttgaa tcttagctaa gacagcttcc ttacggtcat
     8221 tgagatttgt cagactttta tccaaatcaa taatagcctt aatcgccacc tcatccagac
     8281 taccagtcat gtccttacga taacgcgcga taaagggaat agtcgcccct tcagctgtca
     8341 aacttagaac ggtatcaatt tgctttaacg tcactcccaa atcctgagag attttttcat
     8401 attttttatc cataaatcta ttataccaca agctggaagg ctttctccaa tccttttcat
     8461 actcaatgaa aatcaaaaag caaactagga agctagccgc aggctgctca aaatactgtt
     8521 ttgaggttgt ggataagact gacgaagtca gctcaaaaca ctgttttgag gttgtggata
     8581 gaactgacga agtcagtaac cgtactacgg taaggcgaag ctgacgtggt ttgaagagat
     8641 tttcgaagtg tatcaactat cgaaaacaaa ttaaaaaact cccttttccg caaaataata
     8701 gtataataga ggtagaattt agaatcgagg tacacctatg gctgtcaaat ttacaaaacg
     8761 agacgacttg gacaagatgt ttgaagagtt tgctaaactc cctgatttga aacaagttac
     8821 tttccctgat gacaaagaga aaaaagtcaa agcagaaaag aaaaactaga tgactgcttt
     8881 tcaacaactc ccatctagtg tacttcaaac tggagccatt tttctctcca ttatcattga
     8941 agcccttccc ttcgttctga taggaagcat tgtctcaggg ctgattgaag tttatatcac
     9001 acctgacaag gtttatcatt ttctccctcg aaatcgttgg gggagaatct tttttgggac
     9061 ctttgtcggt atacttttcc cttcttgtga atgtggaatc gtccccatca tcaatcgttt
     9121 tctggaaaaa aaggttccaa gttacacggc cgttcctttt cttgtgacag cacctgttat
     9181 caatcccatt gttctttttg cgacctattc tgcctttggc aactccttcc atgtcgccct
     9241 attacgagct ctgggttcca ttcttgtggc tgtaatacta ggaatttttc taggattttt
     9301 ctggcaagaa ccgattcaga aagaaaatcg tctggcttgt catgagcatg atttttctta
     9361 cttgagttct gcaaaaaaag tttttcaagt ctttgtgcag gccattgatg aattttttga
     9421 tacggggcgt tatttggtat ttggctgcct ctttgcttct ataatacagg tctacgttcc
     9481 gactcggatt ctgacctcta tcagtgcgac tcctcttttt gccatcctgc tcttgatgct
     9541 tttggccttt cttctttcgc tctgtagtga ggcggatgcc tttataggtg cttctctact
     9601 ctcgagtttc ggtttggctc cagttctggc ctttctcgtc attggcccaa tgctggatat
     9661 caaaaatatt ctcatgatga aaaattactt gaaagcacga tttattagtc acttcattac
     9721 gattgtgact ctggtcgttt tagcctattc tctcttgatt ggagtcatcc tatgattcga
     9781 tttttagttt tagctggcta ttttgaactg actatttacc tccatctgtc gggcaaacta
     9841 aaccagtaca tcaacatgca ctattcctat ctggcctata tttccatggt gctttccttt
     9901 atcttggcaa ttgttcaatt gtatatctgg atgaagcaag tcaaaaccca cagtcatctg
     9961 aacagccgat tggccaagat gacgagtatt tctcttctgg ctattccact tgtcatcggc
    10021 ttaactttcc caactgttag cttggattct cagactgttt ctgctaaagg ttatcatttc
    10081 cccctatcgg aaggaacgga tctagccatt cagacaagcg aagggacgac aagccaatat
    10141 ttgaaaccag ataccagttc ttatttttca aaatcagcct atgaaaagga aatgcgaacg
    10201 gcggcggata aatacttatc ccaagatagt attcagatca ctaatgaaaa ctatatggaa
    10261 gtcatggagg ctatctacga ctatccagat gagtttgagg gcaagacaat ccagtttaca
    10321 ggctttgtct ataacgaccc cagtcatgcc aatagtcaat ttctgttccg attcggcatt
    10381 atccactgta tcgcagattc tggtgtctat ggattgctga ccaagggcaa tacccggcag
    10441 tatgaaaaca acacttggat ttcagccaaa ggaaaactgg tcaatcacta ccataaagaa
    10501 ctcaaacaaa accttccaac cttggaaatc gacagcttta ccaaagtcga taaaccagaa
    10561 aatccctatg tatatagagc tttttaagaa aatcaaaata aaaacgaaca agttctcttc
    10621 tgaataaca
//
LOCUS       DAVLHC010000060        10561 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.061, whole genome shotgun sequence.
ACCESSION   DAVLHC010000060 DAVLHC010000000
VERSION     DAVLHC010000060.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10561)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10561)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10561
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.061"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(105..542)
                     /locus_tag="VXE25_001831"
     CDS             complement(105..542)
                     /locus_tag="VXE25_001831"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA-binding protein"
                     /protein_id="HEV0772248.1"
                     /translation="MSQEFINPSDGVIRQYLATSKTLAVVGLSDREETTSNRVTKEMQ
                     ARGYKIIPVNPKAAGGEILGEKAYASLAEIPFPVDIVNVYRRSEFLPDVARDFLKADA
                     KIFWAQLGLESLEAKEILRDGGCDDIVMNRCIKREHTRLIEEA"
     gene            complement(627..3260)
                     /gene="polA"
                     /locus_tag="VXE25_001832"
     CDS             complement(627..3260)
                     /gene="polA"
                     /locus_tag="VXE25_001832"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014932012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase I"
                     /protein_id="HEV0772249.1"
                     /translation="MDKKKLLLIDGSSVAFRAFFALYQQLDRFKNAAGLHTNAIYGFQ
                     LMLSHLLERVEPSHILVAFDAGKTTFRTEMYADYKGGRAKTPDEFREQFPFIRELLDH
                     MGIRHYELAQYEADDIIGTLDKLAEQDGFDITIVSGDKDLIQLTDEHTVVEISKKGVA
                     EFEAFTPDYLMEEMGLTPAQFIDLKALMGDKSDNIPGVTKVGEKTGIKLLLEHGSLEG
                     IYENIDGMKTSKMKENLINDKEQAFLSKTLATIDTKAPIAIGLEDLVYSGPDVENLGK
                     FYDEMGFKQLKQALNVSSADVAEGLDFTIVDQISQDMLSEESIFHFELFGENYHTDNL
                     VGFAWSCGDKLYATDKLELLQDPIFKDFLEKTSLRVYDFKKVKVLLQRFGVDLQAPAF
                     DIRLAKYLLSTVEDNEIATIASLYGQTYLVDDETFYGKGVKKAIPEREKFLEHLACKL
                     AVLVETEPVLLEKLSENGQLELLYDMEQPLAFVLAKMEIAGIVVKKETLLEMQAENEL
                     VIEKLTQEIYELAGEEFNVNSPKQLGVLLFEKLGLPLEYTKKTKTGYSTAVDVLERLA
                     PIAPIVKKILDYRQIAKIQSTYVIGLQDWILADGKIHTRYVQDLTQTGRLSSVDPNLQ
                     NIPARLEQGRLIRKAFVPEWEDSVLLSSDYSQIELRVLAHISKDEHLIKAFQEGADIH
                     TSTAMRVFGIERPDNVTANDRRNAKAVNFGVVYGISDFGLSNNLGISRKEAKAYIDTY
                     FERFPGIKNYMDEVVREARDKGYVETLFKRRRELPDINSRNFNIRGFAERTAINSPIQ
                     GSAADILKIAMIQLDKALVAGGYQTKMLLQVHDEIVLEVPKSELVEMKKLVKQTMEEA
                     IQLSVPLIADENEGATWYEAK"
     gene            3516..3866
                     /locus_tag="VXE25_001833"
     CDS             3516..3866
                     /locus_tag="VXE25_001833"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001811778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PD-(D/E)XK nuclease family transposase"
                     /protein_id="HEV0772250.1"
                     /translation="MLRHPGISPTNDLIAKKIFSNPEITCQFIRDMLDLPAKNVTILE
                     GSDIHVLLSMPYSVQDFYTSIDVLAELDNGTQVIIEIQVHHQNFFINHLWAYLCSQVN
                     QNLEKIRQREGDTH"
     gene            4081..4197
                     /locus_tag="VXE25_001834"
     CDS             4081..4197
                     /locus_tag="VXE25_001834"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000233180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="damage-inducible protein CinA"
                     /protein_id="HEV0772251.1"
                     /translation="MVGVFRQQALYPATATSHYPSKSTAGLQELVRGGQENV"
     gene            4190..4423
                     /locus_tag="VXE25_001835"
     CDS             4190..4423
                     /locus_tag="VXE25_001835"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772252.1"
                     /translation="MFNQLHMREEQVLLAQDYALETARAEGLEQGLERGKVEGRAERK
                     LFTFLDIVRQGLLTSEVASQQLGMSVSEFEALL"
     gene            4550..4831
                     /locus_tag="VXE25_001836"
                     /pseudo
     CDS             4550..4831
                     /locus_tag="VXE25_001836"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436393.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
     gene            complement(4965..5933)
                     /locus_tag="VXE25_001837"
     CDS             complement(4965..5933)
                     /locus_tag="VXE25_001837"
                     /EC_number="2.7.6.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006149122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-phosphate diphosphokinase"
                     /protein_id="HEV0772253.1"
                     /translation="MSFSDLKLFALSSNKELAERVAQEIGIELGKSSVRQFSDGEIQV
                     NIEESIRGKHVFILQSTSSPVNDNLLEILIMVDALKRASAESVNVVMPYYGYARQDRK
                     ARAREPITSKLVANMLEVAGVDRLLTIDLHAAQIQGFFDIPVDHLMGAPLIADYFERR
                     GMVGSDYVVVSPDHGGVTRARKLAEFLKTSIAIIDKRRSVDKMNTSEVMNIIGKVEGK
                     TCILIDDMIDTAGTICHAADALAEAGAVEVYASCTHPVLSGPATDNIQKSAIKKLVVL
                     DTIYLPEERLIDKIEQISIAHLLGDAIVRIHEKRPLSPLFDIEKKI"
     gene            complement(6078..6893)
                     /locus_tag="VXE25_001838"
     CDS             complement(6078..6893)
                     /locus_tag="VXE25_001838"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000749763.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PrsW family intramembrane metalloprotease"
                     /protein_id="HEV0772254.1"
                     /translation="MKKSSILFIFILLLCIDLQYETIYYTDGSRSGAEYGLMGVSIFL
                     ALFYMIPALYFLFRIGKKWELPKKVLILSLLGGMFLSGWLSSFANTYIHDLLGVLFPD
                     SPFLNAFESAIVAPLVEEPLKLLPLVFVLALIPVRKLKSLFLLGIASGLGFQMIEDIG
                     YIRTDLPEGFDFTISRILERIISGIASHWTFSGLAVVGVYLLYRAYKGQKVGKKQGLI
                     FLGLALGTHFLFNSPFVELETELPLAIPVVTAIALYGFYHAYCFVEKHNELMT"
     gene            complement(6918..7415)
                     /locus_tag="VXE25_001839"
     CDS             complement(6918..7415)
                     /locus_tag="VXE25_001839"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007285146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbonic anhydrase"
                     /protein_id="HEV0772255.1"
                     /translation="MSYFEQFMQANQAYVALHGQLNLPLKPKTRVAIVTCMDSRLHVA
                     QALGLALGDAHILRNAGGRVTEDMIRSLVISQQQMGTREIVVLHHTDCGAQTFENEPF
                     QEYLKEELGVDVSDQDFLPFQDIEESVREDMQLLIESPLIPDDVIISGAIYNVDTGSM
                     TVVEL"
     gene            complement(7488..8849)
                     /gene="radA"
                     /locus_tag="VXE25_001840"
     CDS             complement(7488..8849)
                     /gene="radA"
                     /locus_tag="VXE25_001840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000336571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RadA"
                     /protein_id="HEV0772256.1"
                     /translation="MAKKKATFVCQNCGYNSPKYLGRCPNCGSWSSFVEEVEVAEVKN
                     ARVSLTGEKTKPMKLAEVTSTNVNRTKTEMEEFNRVLGGGVVPGSLVLIGGDPGIGKS
                     TLLLQVSTQLSQVGTVLYVSGEESAQQIKLRAERLGDIDSEFYLYAETNMQSVRAEVE
                     RIQPDFLIIDSIQTIMSPEISGVQGSVSQVREVTAELMQLAKTNNIAIFIVGHVTKEG
                     TLAGPRMLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEIGIFEMQSGGLVEVLNP
                     SQVFLEERLDGATGSSIVVTMEGTRPILAEVQALVTPTMFGNAKRTTTGLDFNRASLI
                     MAVLEKRAGLLLQNQDAYLKSAGGVKLDEPAIDLAVAVAIASSYKDKPTNPQECFVGE
                     LGLTGEIRRVNRIEQRINEAAKLGFTKIYVPKNSLTGITLPKEIQVIGVTTIQEVLKK
                     VFA"
     gene            complement(8863..9378)
                     /locus_tag="VXE25_001841"
     CDS             complement(8863..9378)
                     /locus_tag="VXE25_001841"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HEV0772257.1"
                     /translation="MKIIFVRHGEPDYRELEERSYIGFGIDLAPLSEMGRQQVQKLSK
                     NPLLSSAEIIVSSAVTRALETASYVVCATGLPLRVEPLLHEWQVYKTGIENFETARRL
                     FLENKGELLPNSPIQYETATEMKSRFLECMSKYREHQTVVVVAHRMLMRQFVPNEKID
                     FCQVIECELEI"
     gene            complement(9380..9823)
                     /locus_tag="VXE25_001842"
     CDS             complement(9380..9823)
                     /locus_tag="VXE25_001842"
                     /EC_number="3.6.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dUTP diphosphatase"
                     /protein_id="HEV0772258.1"
                     /translation="MKIRGFELVSSFTDENLLPKRETAHAAGYDLKVAVRTVVAPGEI
                     VLVPTGVKAYMQPTEVLYLYDRSSNPRKKGLVLINSVGVIDGDYYGNPGNEGHIFAQM
                     KNITDQEVVLEVGERIVQAVFATFLIADGDAADGVRTGGFGSTGH"
     gene            complement(9880..9977)
                     /gene="ffs"
                     /locus_tag="VXE25_001843"
     ncRNA           complement(9880..9977)
                     /ncRNA_class="SRP_RNA"
                     /gene="ffs"
                     /locus_tag="VXE25_001843"
                     /product="signal recognition particle sRNA small type"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00169"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00169"
     gene            complement(10010..10477)
                     /locus_tag="VXE25_001844"
     CDS             complement(10010..10477)
                     /locus_tag="VXE25_001844"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside deaminase"
                     /protein_id="HEV0772259.1"
                     /translation="MYYTLEEKEVFMREALREAEIALEHDEIPIGCVIVKDGEIIGRG
                     HNAREELQRAVMHAEIMAIEDANLSEESWRLLDCTLFVTIEPCVMCSGAIGLARIPNV
                     VYGAKNQKFGAAGSLYDILTDERLNHRVEVEIGILEDECAAIMQDFFRNRRKK"
BASE COUNT         3244 a         2600 c         1848 g         2869 t
ORIGIN      
        1 caacctcaaa acagtgtttt gagcagcccg cggctagttt cctagtttgc tctttgattt
       61 tcattgagta taacacaaaa ggtagcccat cagctacctt tttcttatgc ttcctcaatc
      121 aagcgagtat gttctctctt gatacagcga ttcatcacga tatcatcaca tccaccatca
      181 cgcaaaatct ctttcgcttc taaactttca agtcctagct gtgcccaaaa aatcttggca
      241 tcagctttga gaaaatcacg cgccacatcg ggcagaaatt cactgcgacg ataaacattg
      301 acaatatcta caggaaaagg aatttcagcg aggctagcat aagccttttc acccaagatt
      361 tcgccacctg ccgccttggg attgactggg atgattttat agccccgagc ctgcatttcc
      421 tttgtcactc gattgctggt tgtttcttca cggtcagaca aacccaccac agcaagggtt
      481 ttactcgttg cgagatactg acgaatcacg ccatcacttg gattgataaa ttcttgactc
      541 atagaaaacc tcctttttca tcagtatagc acattttgaa aaggtttgca gaattctact
      601 acaaaaaagg aggactagcc ccctttttat ttagcctcgt accaggttgc cccttcattc
      661 tcatctgcga taagaggaac actgagttga atggcttctt ccatggtttg tttcaccaat
      721 tttttcatct ctaccaattc agatttaggc acttcaagga cgatttcatc gtgcacttgt
      781 aacagcatct tagtctgata accacctgca accaaggctt tatccagctg aatcatggca
      841 atcttgagaa tatctgctgc cgaaccctgg ataggtgagt tgatagcagt tcgctccgca
      901 aaaccacgaa tattgaagtt gcgcgaattg atatctggca actcacggcg acgcttaaag
      961 agggtctcta catagccctt atcacgcgcc tcccgcacca cttcatccat gtagttttta
     1021 atacctggaa aacgttcaaa gtaggtatca atgtaggctt tggcttcctt acgactaatt
     1081 cccaaattat tagacaagcc aaagtctgaa atcccataaa ccactccaaa gttaactgcc
     1141 ttggcattgc gacggtcatt tgcagtcaca ttatcaggac gctcaatgcc aaagacccgc
     1201 atggctgtcg aagtatggat atctgccccc tcttggaagg ccttaatcaa gtgctcatcc
     1261 ttagaaatat gcgccaaaac gcgcaattca atctgtgaat agtcagagct gagtagcaca
     1321 ctatcctccc actctggcac aaaagccttc cgaatcaagc gcccctgttc caatcgggca
     1381 ggaatatttt gcaagtttgg atccacacta gacaaacgcc cggtctgggt caaatcctgc
     1441 acatagcgag tatgaatctt tccatcagcc aaaatccagt cctgcaagcc aattacataa
     1501 gtagattgaa tcttagcaat ttgacggtaa tccaggattt tcttaacaat cggagcaata
     1561 ggagcgagac gctccaacac atccactgct gtcgaataac ctgtcttggt tttcttagtg
     1621 tattctagag gaagtcccaa tttctcaaag agaagcacgc ccaactgctt aggcgagttg
     1681 acattaaact cctcaccagc cagctcgtaa atctcttgag tcagtttttc aatgacaagc
     1741 tcattttcag cctgcatctc aagcaaggtc tctttcttga ccacaatccc agcaatttcc
     1801 atcttggcaa gaacaaaagc cagaggttgc tccatatcat aaagaagctc taattgccca
     1861 ttttcgctga gtttttcaag tagaacaggc tctgtttcta ccaaaacagc aagtttacaa
     1921 gctaagtgtt ccaagaattt ctcacgttca ggaatggcct ttttaacacc cttaccgtag
     1981 aaagtttcat catcaaccaa gtaagtctga ccataaagac tagcgatggt cgcaatttca
     2041 ttgtcctcca cagtcgaaag gaggtattta gccaaacgga tgtcaaaagc aggcgcctgc
     2101 aaatccacac caaaacgttg caaaagaact ttaaccttct taaagtcata aactctcaga
     2161 gatgtttttt ctaagaaatc cttgaaaatc gggtcttgca acagctcaag cttgtctgtg
     2221 gcatagagct tatccccaca agaccaggca aatccaacca aattatccgt atggtaattc
     2281 tcaccaaaaa gctcaaagtg gaagatagac tcttcactca gcatatcttg actgatttgg
     2341 tcaacaatag taaaatccaa accctcagcc acatcagctg acgacacatt taaagcctgc
     2401 ttgagctgtt tgaatcccat ctcatcgtaa aatttcccaa gattttcaac atctggacca
     2461 ctatagacca agtcctctaa accaatcgca atcggtgcct tggtatcaat ggtcgctagt
     2521 gttttagaca aaaaggcctg ttccttgtca ttgatgagat tttccttcat cttagaagtc
     2581 ttcattccat caatattttc ataaatcccc tcaagcgaac catgctccag caagagctta
     2641 atacccgtct tttcaccgac tttggtcacc ccagggatat tatccgactt atcacccatg
     2701 agcgccttga gatcgataaa ctgagctggt gtgaggccca tttcttccat gaggtaatct
     2761 ggcgtaaagg cctcaaactc agccacacct ttcttggaaa tttcaaccac cgtatgctca
     2821 tccgtcagct gaatcaaatc cttgtcccca ctgacaatgg taatatcaaa accatcctgc
     2881 tctgctagct tatccagcgt cccaatgatg tcatccgcct catactgagc cagctcatag
     2941 tgacgaatcc ccatatgatc cagcaactca cgaatgaaag gaaattgctc acgaaactca
     3001 tcaggagtct tggcccgacc acccttatag tccgcataca tctctgtccg gaaggtcgtc
     3061 tttcccgcat caaaagccac caaaatatga ctcggctcaa cccgctccaa caaatgactc
     3121 aacatcaact gaaaaccata aatcgcattg gtatgcaaac cagccgcatt cttaaaacgg
     3181 tccaactgct gatacagcgc aaaaaacgcc cgaaaagcta cagaagaccc atcaatcaat
     3241 aataattttt tcttatccat acacccatta taaaggaaag aatcaaaaaa taccattggg
     3301 aagagctaga gctagtattt ttcaaacttt ttccgaataa atagatagag ccagagaatt
     3361 tagtaaacct agatttaaaa atgtgctata atatagtata ttgaatctat aatagtacac
     3421 cttgactgct aaaatatttc tataaattaa tttgactttc ctgatagagt tattcacatc
     3481 ttatttcaac tcactataga aggaggaata ggaggattct cagacatccg ggcatcagcc
     3541 caactaatga tttgattgct aagaaaatat tcagcaatcc agaaatcact tgtcaattta
     3601 ttcgcgatat gctggacttg ccagcaaaaa atgtgaccat tttggaggga agcgatattc
     3661 acgtattact ctccatgcct tactcggtgc aggattttta taccagtata gacgtcttgg
     3721 cggagttgga taacggtact caagtaatta ttgagattca agtccatcat cagaattttt
     3781 tcatcaatca cttgtgggct tacctgtgca gtcaggttaa tcaaaatctt gaaaaaattc
     3841 gtcagcgaga aggtgatact cactagagct acaaacacat cgctcctgtt tacgccattg
     3901 ctatcgtgga tagtaattat ttctcagatg acctggcttt tcatagcttt agtatgcgcg
     3961 aagacacaac aggtgaggta ttggcgatta ccaacaatgg acaggaaaac catctggtta
     4021 agatggcatt cttggaatta aaaaatacag agaaaccagc aaagacaagg ttcgcaagcc
     4081 atggttggag tttttcggca acaagccctt tacccagcaa ccgcaacgag ccattaccca
     4141 agcaaatcaa ctgctggact acaagagctg gtccgaggag gacaggaaaa tgtttaatca
     4201 actacatatg cgagaagaac aagtcttgtt agcacaggac tatgccttgg aaactgctag
     4261 ggctgaaggc cttgaacaag gattagagcg tgggaaagtt gaaggaaggg cagaaaggaa
     4321 actttttacc ttcctagaca tagtacgcca aggtcttctg acttctgagg ttgccagcca
     4381 gcaattaggt atgtcagtat ctgaatttga ggcactgttg taaaatggct ccataatatc
     4441 catagtgggt aaatccccta tggatattat ggagcctatt ttgtgtagaa aaaaagtccc
     4501 atatgaccta taatgaaaag cgacaaaaca actcattaga aagaatcata tggaacaatt
     4561 acattttatc acaaaattac tagacattaa agaccctaat gtccagattt taaacatcat
     4621 caataaggat acacacaagg aaatcatcgc caaactggac tacgacgccc catcttgccc
     4681 tgagtgcgga aaccaattga agaaatatga ctttcaaaaa ccttctaaaa ttccttatct
     4741 tgaaacgact ggtataccta ctagaattct ccttagaaag cgtcgattca agtgctatca
     4801 ctgttcaaaa atgatggtcg ctgaaacttc tgatgacgta cagtcatatt tcttttcttt
     4861 ttattatatc acagttttaa atctagcttt actagattca ccgctactat ctatttattc
     4921 ggaaaaaaga cgaaaaaacc tgagaatcat ctcaggcttg gtcattaaat ttttttctca
     4981 atatcgaaaa gtggagaaag tggtcgtttt tcatgaatac gtacgatagc atcccctagg
     5041 agatgagcga ttgaaatctg ctcaatctta tcaatcaaac gctcttctgg cagatagatg
     5101 gtatccaaaa caaccaattt cttaatagct gatttttgga tattgtccgt agcaggacca
     5161 gaaagaactg ggtgcgtaca gcttgcatag acttcaacag caccagcttc cgcaagagca
     5221 tctgccgcat gacaaatcgt tccagcggta tcaatcatat catcaatcaa gatacaagtc
     5281 ttgccttcaa ccttaccgat gatgttcata acttcactag tattcatctt atcaacgctg
     5341 cgacgtttat caataatagc gatagatgtt ttcaaaaatt ctgccaactt acgagcacga
     5401 gtcacccctc catggtccgg gctgacaacc acatagtcag aaccaaccat accacgacgc
     5461 tcaaaataat ctgcaatcag aggagcaccc atcaaatgat ccacaggaat atcaaagaat
     5521 ccttgaattt gcgcagcatg caagtcgatg gtcaataaac gatccactcc agctacttca
     5581 agcatatttg cgacaagttt tgaagtgatt ggctcacgcg ctctcgcctt tctatcctga
     5641 cgtgcatacc catagtaagg catgacaaca ttgacagatt ctgcactcgc acgcttcaaa
     5701 gcatctacca taatcaaaat ttcaagcaga ttgtcattta caggcgaact agttgattgt
     5761 aggataaaga cgtgtttccc acggattgat tcttcaatgt tgacctgaat ctctccatct
     5821 gaaaattggc gaacacttga tttccccaac tctatcccaa tctcctgcgc tacacgttct
     5881 gccaattctt tattagaaga aagggcaaac agctttaaat cagaaaaaga catgatttcc
     5941 tccggtatat atgtataact tgtgcttttc acaagatttt ccatctacca ttgtagcgct
     6001 ttttgcacta tttttcaatc aaaaataaaa gaagggcacc atatttgtac ccttgcatca
     6061 ttcttttgaa aaatattcta ggtcatcaac tcattgtgtt tctcaacaaa gcaataagca
     6121 tgataaaaac catagagagc aatagccgta accactggaa tcgctaaagg caactctgtt
     6181 tccaactcca caaaaggaga gttaaacaag aagtgagttc ccaaggctaa acctagaaaa
     6241 ataaggccct gtttcttgcc aaccttctgt cctttatagg ctctgtaaag caagtaaaca
     6301 cctactacag ctagacctga aaaagtccag tgagaggcaa ttcctgagat gatacgctct
     6361 aaaattcgcg aaatagtaaa gtcaaagccc tctggcaaat ccgtacgaat ataaccaata
     6421 tcctcaatca tttggaatcc caaaccggaa gcaattccaa gtaaaaacaa agattttaat
     6481 tttcgcacag gaatcaaagc caaaacaaaa acaagtggca ataatttcaa gggttcttct
     6541 accaaaggag ccacaatagc actttcaaag gcatttaaaa atggactatc tgggaaaaga
     6601 acccccagta aatcatgtat ataagtatta gcaaaactag acaaccagcc tgaaaggaac
     6661 atccctccca ataaagacag aatcaaaacc ttctttggca attcccattt tttcccaata
     6721 cggaagagaa aataaagagc cggaatcatg taaaagagag ctagaaagat agaaactccc
     6781 attagtccat attccgcacc tgacctcgaa ccgtccgtat agtagatggt ttcatactgt
     6841 aaatcaatac atagcaataa aataaaaata aataaaatac tgcttttctt catacacttt
     6901 ctttctaaat gaagtattta taattctacg actgtcatac ttcctgtatc aacattgtaa
     6961 atagcaccag agataatgac atcgtctggt attaggggag actcgataag cagttgcata
     7021 tcctcgcgta cactctcttc tatatcttgg aagggcaaga agtcctggtc tgacacatct
     7081 acacctaatt cctcttttaa atactcctga aaaggttcat tttcaaaggt ctgagcacca
     7141 cagtctgtat ggtgcaatac cacaatctct cttgtcccca tttgttgctg ggaaataact
     7201 agcgaacgaa tcatgtcttc agtcactcga ccacctgcat tccgcaagat atgagcatcc
     7261 ccaagtgcca agcccagagc ttgcgcaacg tgcagacgag agtccataca ggtcacaata
     7321 gctactcttg ttttgggttt aagtggcaga tttaactgcc catgtagggc aacataagcc
     7381 tgattagctt gcataaactg ttcaaaatac gacacgattc cctccttgaa aatttgatag
     7441 tcaaatattt ctcctatctt atcattttta agagaatttg tcacggatta tgcaaagacc
     7501 tttttcaaaa cttcctgaat cgttgtcacg ccaatgacct gaatttcctt aggcagagtg
     7561 attcctgtca aggaattctt aggtacataa atcttagtaa agcccagttt agcagcttcg
     7621 ttgatgcgtt gctcaatacg attcacgcgc cgaatctctc ctgtcaagcc cagttctccg
     7681 acaaaacatt cctgaggatt agttggcttg tctttgtagc tcgaagcaat agcaactgca
     7741 acagccaagt caatcgcagg ttcatccaat ttaacaccac cagcagattt gagataggca
     7801 tcctgatttt gcaagagaag ccctgcccgt ttttccaaaa cagccataat caagctagca
     7861 cggttaaaat caagtcctgt cgtagtacgc ttggcatttc caaacatggt cggtgttacc
     7921 aaagcctgaa cctccgccaa aatcggacgc gtcccttcca tggttacaac gatggaggaa
     7981 ccagtcgccc catccaaacg ctcttctagg aaaacttgac tcggattgag tacctcaacc
     8041 aagccgcccg actgcatctc aaaaatccca atctcattag tggaaccaaa acgatttttg
     8101 accgctctca aaatacgaaa ggtgtggtga cgctcccctt caaagtaaag caccgtatcc
     8161 accatatgct ccaacatacg aggcccagcc aaggttcctt ctttggtcac atgacctacg
     8221 ataaagatgg caatgttatt ggtcttggcc aactgcatga gttcagcggt cacttcacgc
     8281 acctgagaaa cagacccctg cacccctgaa atctcaggag acatgatggt ctggatggaa
     8341 tcaataatga gaaagtctgg ctggatacgc tccacttctg cacgaacact ctgcatattg
     8401 gtctctgcat agagataaaa ctcactatca atatcaccta agcgctctgc acgtagttta
     8461 atctgctggg cagactcctc cccactgaca tagagaactg tccccacttg ggacaactgg
     8521 gttgagactt gtaggagaag agttgatttc ccaatcccag gatccccacc gataaggacg
     8581 agacttcctg gtaccactcc gcctccaagc acacggttga attcctccat ctccgtcttg
     8641 gttcgattga cattggtgga agtcacctca gctagtttca tgggcttggt tttctcacct
     8701 gtcaaggaca cacgcgcatt cttaacttcg gcaacctcaa cctcttccac aaaagaagac
     8761 caagacccac agttggggca acgtcccaga tatttagggg aattataccc acaattttga
     8821 catacaaatg tcgctttttt ctttgcgatg acaaacctct ttctatatct ctaactcaca
     8881 ctcaatcact tggcaaaaat caatcttctc atttggcaca aactggcgca tgagcattcg
     8941 atgagcaaca actaccacag tctgatgttc tcgatactta gacatacatt ctagaaaccg
     9001 agacttcatt tccgtagctg tctcatattg aataggacta ttaggaagca actccccctt
     9061 gttttctaaa aacagtcttc tagctgtttc aaagttttct attcctgttt tatagacctg
     9121 ccattcatgt aataaaggct ctactcttaa aggaagaccc gtagcacaga ccacatacga
     9181 agccgtttct aaagctcttg tgactgcaga agatacgatt atttcagctg acgagagtaa
     9241 aggatttttg ctcaatttct ggacttgctg ccgtcccatc tcagacaagg gtgccaaatc
     9301 tatcccaaat cctatataag aacgctcctc taactcacgg taatctggct ccccatgacg
     9361 tacaaagata atcttcattc tagtgccctg tcgatccaaa tccaccagtt cgaacgccat
     9421 cagctgcatc tccatctgca attaagaaag tagcaaaaac agcctggaca atacgctccc
     9481 caacttcaag aacaacctct tggtctgtga tattcttcat ctgcgcaaaa atatgccctt
     9541 catttccagg atttccataa taatccccat caatgacccc aactgagtta attaaaacca
     9601 agcccttctt acgaggattt gaagaacgat catagaggta gagaacctca gtcggctgca
     9661 tataagcctt aacccctgtc ggaaccaaga caatctctcc tggcgcaaca actgtacgca
     9721 cagcaacctt taagtcgtaa ccagccgcat gcgctgtctc acgcttgggc aataaatttt
     9781 catctgtaaa actcgaaacc aattcaaaac cacgaatttt cataattttc tcttttctat
     9841 tatcatttat tctagattat tctatcttat ttattcggaa aaagcacgaa aaaaagagca
     9901 cacaattcaa atcgcttagg gctgctggat tcctcccctg acccgcttca cgcagaactg
     9961 ttgctccact atttattata tcacattcct attcatttta aaagcaaaat tattttttcc
    10021 gtctatttct aaaaaaatcc tgcatgatag ctgcgcattc atcttccaaa attcctattt
    10081 caacctccac acgatgattg agacgctcat ctgtcaagat atcgtacaaa ctcccagcag
    10141 cgccaaattt ctggttttta gccccataga ccacatttgg aatgcgggca agcccaatcg
    10201 ccccactaca catgacacaa ggttcaatgg tcacaaaaag tgtgcaatcc agcaagcgcc
    10261 agctctcctc actcaagttc gcatcctcta tagccataat ttccgcatgc ataaccgctc
    10321 gctgtaattc ctcacgcgca ttatgcccac gaccaatgat ttccccatct ttgacaatca
    10381 cacaaccaat tggaatttca tcgtgttcaa gagcaatctc agcctctctc aaagcctccc
    10441 tcataaagac ttctttttct tcaagcgtat aatacatctc ttttctcttt tcctacttat
    10501 cgattttatt attatatcat gaatcccaac acaaaaaaag ccaccgaatg cggtgactct
    10561 a
//
LOCUS       DAVLHC010000061        10532 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.062, whole genome shotgun sequence.
ACCESSION   DAVLHC010000061 DAVLHC010000000
VERSION     DAVLHC010000061.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10532)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10532)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10532
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.062"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            147..302
                     /locus_tag="VXE25_001845"
                     /pseudo
     CDS             147..302
                     /locus_tag="VXE25_001845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000710121.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol kinase family lipid kinase"
     gene            502..3777
                     /gene="rexB"
                     /locus_tag="VXE25_001846"
     CDS             502..3777
                     /gene="rexB"
                     /locus_tag="VXE25_001846"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002206154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent nuclease subunit B"
                     /protein_id="HEV0772260.1"
                     /translation="MKLLYTDIRTSLTEILTREAEELVAAGKRVFYIAPNSLSFEKER
                     AVLEYLSQQASFSITVTRFAQMARYLVLNDLPAKTTLDDIGLGLAFYKCLAELDPKDL
                     RVYGAIKQDPQLIQQLIELYHEMTKSQMSFLDLENLTDEDKRADLLLIFEKVTAYLNQ
                     GQLAQGSQLSHLIEAIENDKVSSDFNQIALVIDGFTRFSAEEERVVDLLHGKGVEIVI
                     GAYASKKAYTSPFSEGNLYQASVKFLHHLASKYQTPAQDCSQTHEKMDSFDKASRLLE
                     SSYDFSELALDVDEKDRENLQIWSCLTQKEELELVARSIRQKLHENSDLSYKHFRILL
                     GDVASYQLSLKTIFDQYQIPFYLGRSEAMAHHPLTQFVESILALKRYRFRQEDLINLL
                     RTDLYTDLSQSDIDAFEQYIRYLGINGLPAFQQTFTKSHHGKFNLERLNVLRLRILAP
                     LETLFASRKQKAENLLQKWSVFLKEGAVTKQLQDLTTTLEAVEQERQAEVWKAFCHVL
                     EQFATVFAGSQVSLEDFLALLHSGMSLSQYRTIPATVDTVLVQSYDLIAPLTADFVYA
                     IGLTQDNLPKISQNTSLLTDEERQNLNQATEEGVQLLIASSENLKKNRYTMLSLVNSA
                     RKQLFLSAPSLFNESESKESAYLQELIHFGFRRREKRMNHKGLSKEDMGSYHSLLSSL
                     VAYHQQGEMSDTEQDLTFVKVLSRVIGKKLDQQGLENPAIPISPSSKTLAKDTLQALY
                     PAKQEFYLSTSGLTEFYRNEYSYFLRYVLGLQEELRLRPDARSHGNFLHRIFERALQL
                     PNEDSFDQRLEQAIQETSQEREFEAIYQESLEAQFTKEVLLDVARTTGHILRHNPAIE
                     TIKEEANFGGKDQAFIQLDNGRSVFVRGKVDRIDRLKANGAIGVVDYKSSLTQFQFPH
                     FFNGLNSQLPTYLAALKREGEQNFFGAMYLEMAEPVQSLMAVKSLAGAVVEASKSMKY
                     QGLFFEKESSYLGEFYNKNKANQLTDEEFQLLLDYNAYLYKKAAEKILAGRFAINPYT
                     ENGRSIAPYVQQHQAITGFEANYHLGQARFLEKLDLADGKRLVGEKLKQAWLEKIREE
                     LNR"
     gene            3774..7424
                     /gene="addA"
                     /locus_tag="VXE25_001847"
     CDS             3774..7424
                     /gene="addA"
                     /locus_tag="VXE25_001847"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000767270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase-exonuclease AddAB subunit AddA"
                     /protein_id="HEV0772261.1"
                     /translation="MKLIPFLSEEEIQKLQEAEANSSKEQKKTAEQIEAIYTSGQNIL
                     VSASAGSGKTFVMAERILDQLARGVEISQLFISTFTVKAATELKERLEKKISKKIQET
                     DDVDLKQHLGCQLADLPNAAIGTMDSFTQKFLGKHGYLLDIAPNFRILQNQSEQLLLE
                     NEVFHEVFEAHYQGKQKESFSHLLKNFAGRGKDERGLRQQVYKIYDFLQSTSNPQKWL
                     SESFLKGFEKADFTSEKEKLTEQIKQALWDLESFFRYHLDNDAKEFAKAAYLENVQLI
                     LDEIGSLNQEFDSQAYQAVLARVVAISKEKNGRALTNASRKADLKPLADAYNEERKTQ
                     FTKLGQLSDQITILDYQERYHGDTWKLAKTFQSFMSDFVEAYRQRKRQENAFEFADIS
                     HYTIEILENFPQVRESYQERFHEVMVDEYQDTNHIQERMLELLSNGHNRFMVGDIKQS
                     IYRFRQADPQIFNEKFQRYAQNPQEGKLILLKENFRSSSEVLSATNDVFERLMDQEVG
                     EINYDNMHQLVFANTKLTPNPDNKAEFLLYDKDDTGEEEESQTETKLTGEMRLVIKEI
                     LKLHQEKGVAFKEIALLTSSRNRNDQILLALSEYGIPVKTDGEQNNYLQSLEVQVMLD
                     TLRVIHNPLQDYALVALMKSPMFGFDEDELARLSLQKAEDKAHENLYEKLVNAQKKAS
                     SQKGLIHTALAEKLKQFMDILASWRLYAKPHSLYDLIWKIYNDRFYYDYVGALPNGPA
                     RQANLYALALRADQFEKSNFKGLSRFIRMIDQVLEAQHDLASVAVAPPKDAVELMTIH
                     KSKGLEFPYVFILNMDQDFNKQDSMSEVILSRQNGLGVKYIAKMETGAVEDHYPKTIK
                     LSIPSLTYRQNEEELQLASYSEQMRLLYVAMTRAEKKLYLVGKGSREKLEAKQYPAAK
                     NGKLNSNTRLQARNFQDWLWAISKVFTKDKLNFSYRFIGEDQLTREAIGELETKSPLQ
                     DSSQADNRQSDTIKEALEMLKEVEVYNTLHRAAIELPSVQTPSQIKKFYEPVMDMEGV
                     EIAGQGQSVGKKISFDLPDFSTKEKVTGAEIGSATHELMQIIDLSQQLTLASLTETLK
                     QVQTSQAVRDKINLDKILAFFDTALGQEILANTDHLYREQPFSMLKRDQKSQEDFVVR
                     GILDGYLLYENKIVLFDYKTDRYDEPSQLVDRYRGQLALYEEALSRAYSIENIEKYLI
                     LLGKDEVQVVKV"
     gene            7684..8862
                     /locus_tag="VXE25_001848"
     CDS             7684..8862
                     /locus_tag="VXE25_001848"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772262.1"
                     /translation="MTLPVRKSLHDAVLQASKADTWEQATKEWNEVSLIFNGIGRSNC
                     VCGNAIKYAYELFNGVTGQRLFPIGSDCVRHFHRLSLDQQLEEEEKLLRKVENLTRKA
                     QKKEKIKVNKSDFDERLLKWLWEKGVFKPNRGNQFAPERDYQLFLEVFQGGSWTKAEP
                     KKKARMEEVLEKCIKPFLLGKSDDQLYLVKLGKEKIDYEQELRIQAEKERKKRDKIAK
                     QYADNLVLAMGPAERAYQDYFGFTETLTQEERKWEKILFGKNRAERAIKAKQYQKELE
                     KDQRIASQDPIERKQKQTWLLNSYFRELPEEKARFSRLLLEYRKNGEVPFSTEYLSDH
                     LIDFFYKMKAFEFEIAPEQVRDFLKKSLQEDHRSSAQGSWIEGILLNCLKPFLERLVI
                     "
     gene            9071..>10532
                     /locus_tag="VXE25_001849"
     CDS             9071..>10532
                     /locus_tag="VXE25_001849"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000417171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="G5 domain-containing protein"
                     /protein_id="HEV0772263.1"
                     /translation="MEKYFGEKQERFSFRKLSVGLVSATISSLFFMSVLASSSVDAQE
                     TAGVHYKYVADSELSSEEKKQLVYDIPTYVENDDETYYLVYKLNSQNQLAELPNTGSK
                     NERQALVAGASLAALGILIFAVSKKKVKNKTVLHLVLVAGIGNGVLVSVHALENHLLL
                     NYNTDYELTSGEKLPLPKEISGYTYIGYIKEGKTTSESEVSNQKSSVATSTKQQKVDY
                     NVTPNFVDHPSTVQAIQEQTPVSSTKPTEVQVVEKPFSTELINPRKEEKQSSDSQEQL
                     AEHKNLETKKEEKISPKEKTGVNTLNPQDEVLSGQLNKPELLYREETIETKIDFQEEI
                     QENPDLAEGTVRVKQEGKLGKKVEIVRIFSVNKEEVSREIVSTSTTAPSPRIVEKGTK
                     KTQVIKEQPETGVEHKDVQSGAIVEPAIQPELPEAVVSDKGEPAVQPELPEAVVTDKG
                     ETEVQPESPDTVVSDKGEPEQVAPLPEYTRPQAGAVV"
BASE COUNT         3350 a         2127 c         2214 g         2841 t
ORIGIN      
        1 ctatttttgg ttcattttac tatagtagat tgaaataaga tacgaacagc ttgattaggg
       61 aaatcaaatt aatttctaga aatattttag catccacggt gtactgttat agtttcaatt
      121 tactatagtt caatcattct atcaagaata ttgaatatat aaaggcacgt aatattaaaa
      181 cttcttctga tatcgaatta gagtccgatg ttgatggcga taaatcagac aatctacccg
      241 tcgacattaa gatactggga caacacattg aagtgtattc cgtacctaag aaacaatcat
      301 aaaactcaaa gccttgttac cgaggctttt ttattatgtg attttcagta gccagactta
      361 ttctatctaa tacaagtaaa gctaagtatt taagatttag cagatgatga agaaaagaaa
      421 ggatggccta aatattttaa cagatttacg aggctaatca tggtataata tagggtgatg
      481 aaaaattcca acgaggctga gatgaaatta ctttatactg atattcggac ttctttgaca
      541 gaaattctaa caagagaggc agaagagcta gttgcagctg gcaagcgggt cttctacatt
      601 gcccccaact ctctttcttt tgaaaaggaa cgcgccgtgc tggaatactt gtcccagcag
      661 gcttcttttt cgattaccgt cacgcgcttt gctcaaatgg ctcgctatct ggtcttgaat
      721 gatttaccag ctaaaactac tcttgatgat atcggtcttg ggttggcctt ttacaaatgc
      781 cttgccgaac tcgatcccaa ggacttgcgt gtttatggcg ctattaagca ggatcctcaa
      841 ttgatccagc agttaattga gctttaccat gagatgacca aatctcagat gagttttttg
      901 gacttggaga atttaacaga tgaggataag agggcggatt tactcttgat ttttgagaaa
      961 gtaacagcct atcttaatca aggtcagtta gcccagggaa gtcagttgtc ccatttgatt
     1021 gaggctattg agaatgacaa ggtaagtagt gattttaatc aaatcgcctt ggtcattgac
     1081 ggctttactc gtttttctgc tgaggaagag cgggttgtgg acttacttca cggcaaaggt
     1141 gttgagattg ttatcggggc ttatgctagt aagaaagcct ataccagtcc ttttagcgag
     1201 ggcaatctct accaagccag cgtaaaattt ctccatcatc tggcttctaa ataccaaacg
     1261 cctgctcagg actgttctca aactcatgag aagatggata gttttgacaa ggcctctcgt
     1321 ttgttggagt cttcttatga cttttcagaa ctcgctttgg atgtcgatga gaaagaccgt
     1381 gaaaatttac aaatctggtc ttgtttgacg caaaaggagg agttggagct agtagcccgt
     1441 agtattcgtc agaaattaca tgagaactca gacctgagct acaagcattt tcgtattctc
     1501 ttgggggatg tagcttctta ccagttatct ctcaaaacca tttttgacca gtatcaaatt
     1561 cctttttatc ttggtagaag cgaagccatg gctcatcatc ccttgactca gtttgtcgag
     1621 tctattttag ctttaaaacg ttaccgtttt cgtcaggagg atttgattaa tcttcttaga
     1681 actgatttgt atactgacct cagtcagtct gatattgatg cttttgagca atatatccgc
     1741 tatcttggta tcaatggctt gccagccttt cagcaaacct tcaccaaatc ccaccatgga
     1801 aaatttaatc ttgagcgttt gaatgtcctc cgcctgagaa ttttagcacc tcttgaaacc
     1861 ctctttgcca gccgaaaaca aaaggctgaa aacctcctac aaaaatggag tgtctttcta
     1921 aaagaaggag ctgtgaccaa gcagttacaa gatttgacaa ccactttgga agctgtagaa
     1981 caggaaagac aagccgaagt ttggaaggct ttctgccatg ttttagaaca atttgcgact
     2041 gtttttgctg gttcacaggt tagtctggaa gacttcctag ccttgctcca ttctggaatg
     2101 agtttgtccc aataccgtac cattccagca acagtggaca ctgttctggt gcagagttac
     2161 gatttgattg caccattgac tgctgacttt gtctatgcta ttggactaac tcaggacaat
     2221 ttaccaaaaa tttctcaaaa caccagtctt ctgacagatg aagaaaggca aaatctaaac
     2281 caagcgaccg aagaaggcgt tcaattactg attgccagca gtgaaaatct caagaaaaat
     2341 cgctacacta tgctttcctt ggtcaattct gctcgtaagc agttgttctt gtcggctcca
     2401 agccttttta acgaaagtga aagtaaggaa tctgcctatc ttcaagagtt gatccatttt
     2461 ggatttaggc ggagagagaa gaggatgaat cacaaaggac tgtctaagga ggatatgggg
     2521 tcctatcaca gtcttttgtc tagtctggtt gcctatcacc agcagggtga gatgagcgat
     2581 actgagcaag atttgacttt tgtcaaggtt ctgtcgcgtg tcataggtaa aaaactagat
     2641 cagcaaggtc tggaaaatcc agccatccca atcagtccaa gcagcaagac cttagccaag
     2701 gacaccttgc aagctctcta tcctgccaaa caggagtttt acctgtctac gtcgggtttg
     2761 acagagtttt atcgcaatga atacagttat ttcctacgct acgttttagg cttgcaggag
     2821 gaattacgtt tgcgtcctga tgcccgtagt cacgggaatt tcttgcatcg tatctttgaa
     2881 cgcgccttgc agttgcctaa tgaagattcc tttgaccaac gtctagaaca agctattcaa
     2941 gaaaccagtc aagaacgcga atttgaagct atttatcaag aaagtttgga agcccagttt
     3001 accaaggaag ttttgcttga tgttgcacgg acaactggac atattctccg acacaatcca
     3061 gccatcgaaa ccatcaaaga agaagcaaat tttggtggaa aagaccaagc ctttattcaa
     3121 ttagacaatg gacgcagtgt ctttgtacga ggcaaggtgg accggattga ccgtttgaaa
     3181 gctaatggag cgataggagt agtagactac aaatccagtc tgactcagtt ccagtttcct
     3241 catttcttta atgggctcaa ttctcagtta ccaacctatc ttgctgccct aaaaagagaa
     3301 ggggagcaga actttttcgg cgccatgtac ttggaaatgg ctgaacctgt ccaatctctg
     3361 atggcggtaa aaagtctggc aggagcagtg gtagaagcca gcaaatctat gaaataccaa
     3421 gggctcttct ttgaaaaaga aagcagttat ttaggcgaat tttataacaa aaacaaggct
     3481 aatcaactga cagatgagga atttcagctc ctactggact acaatgccta tctttacaag
     3541 aaagctgctg agaagatttt agcaggccgg ttcgccatca atccttatac tgaaaatggc
     3601 agaagcattg ccccatacgt ccagcaacat caggctatta caggctttga agccaattac
     3661 catctgggcc aagcccgttt cctagaaaag ttggacctag ctgatggcaa gcgtctggtc
     3721 ggagaaaaac tcaagcaagc ttggcttgaa aaaataagag aggagttgaa tcgatgaagc
     3781 ttattccctt tttaagtgag gaggagattc aaaaactgca agaagcagaa gcaaattcga
     3841 gcaaggaaca gaagaaaact gccgagcaaa tcgaagctat ctacacttct ggccagaata
     3901 tcctggtctc agcatcggct ggttctggaa agacctttgt catggcagag cgcattctgg
     3961 accaattggc gcgtggtgtc gaaatttctc aactctttat ctcaaccttt accgtcaagg
     4021 ctgcaactga acttaaagaa cgtttagaga aaaaaatcag caagaaaatc caagaaacag
     4081 atgatgtcga tctcaaacaa cacttgggtt gccagttggc agacctaccc aacgctgcca
     4141 tcggaaccat ggactctttc acacaaaaat tccttggcaa acatggttat ctgcttgata
     4201 ttgcacctaa tttccgtatt ttacaaaacc aaagcgagca acttcttctc gaaaacgaag
     4261 tctttcatga ggtctttgaa gcgcattacc aaggtaaaca gaaagagagc tttagtcatt
     4321 tgctgaaaaa ctttgctggg cgtggcaagg acgaacgggg tctgcgccag caagtctata
     4381 aaatctatga cttcctccaa tccaccagta atcctcaaaa gtggctgagt gaatctttcc
     4441 tcaaaggctt tgagaaagct gattttacca gtgaaaaaga aaaactgact gagcaaatca
     4501 aacaagccct ctgggatttg gaaagctttt tccgttacca tctggataac gatgccaagg
     4561 agtttgcaaa ggctgcctat ttagaaaatg ttcaattaat tctggatgaa attggctccc
     4621 taaatcagga gttcgatagt caggcttatc aggcagtgct tgcgcgtgtt gtcgccatct
     4681 ctaaggagaa aaacggtcga gctctgacta atgccagccg taaggctgat ttgaagcccc
     4741 tggctgatgc ctacaacgaa gagagaaaga cccagtttac taaactagga caattatcag
     4801 accagataac cattctcgac tatcaagaac gttatcatgg agacacttgg aaactagcta
     4861 aaaccttcca atctttcatg agcgattttg tagaggctta tcgtcagaga aaacgacagg
     4921 aaaatgcctt tgaattcgct gatatcagcc attacaccat tgagatttta gaaaatttcc
     4981 cacaagttcg tgagtcttat caggagcgct tccatgaagt catggtcgat gagtatcagg
     5041 ataccaacca tattcaagaa cggatgctgg aattgttgtc taatggccac aatcgcttta
     5101 tggtgggaga tatcaagcaa tccatctatc gtttccgtca ggcagacccg cagattttca
     5161 atgagaaatt ccaacgctat gcgcaaaatc ctcaagaagg caagctcatt ctcctcaagg
     5221 aaaatttccg tagtagttca gaagtgctgt cagcaaccaa tgatgtcttt gaacgtctca
     5281 tggaccaaga ggtcggcgaa atcaactatg ataacatgca ccagcttgtt tttgccaata
     5341 ccaaactgac tcccaatcca gacaacaagg ccgaatttct cctctacgac aaggacgata
     5401 caggtgagga agaagagagt caaacagaaa cgaaactaac aggcgaaatg cgcttagtta
     5461 tcaaggagat ccttaaactt catcaggaaa aaggtgttgc ctttaaggaa attgcccttc
     5521 tgacctctag tcgtaatcgt aatgaccaaa ttctacttgc cctgtctgag tacgggattc
     5581 ctgtcaaaac tgacggagag caaaacaatt atctccaatc cctagaagtg caagtcatgc
     5641 tagacactct tcgtgtcatt cacaatcccc tgcaagacta cgccttggtt gcccttatga
     5701 agtctccaat gtttggtttt gatgaggatg agctagcacg tttgtccctt cagaaagcag
     5761 aggataaagc ccacgaaaat ctctatgaga aactggtcaa tgcacaaaaa aaggcaagta
     5821 gtcaaaaagg cttgattcac acagctctag ctgaaaaact aaagcaattc atggatatcc
     5881 tagcttcttg gcgcttgtat gccaaacccc actctctcta tgacttgatt tggaagattt
     5941 acaacgaccg tttttattat gactatgttg gggctttgcc gaatggtcct gctaggcagg
     6001 ccaatctcta tgccctagca ctgcgtgctg atcaatttga aaagagcaat ttcaaaggtt
     6061 tgtcgcgttt tattcgtatg attgaccaag tcttagaagc ccagcacgat ttggcaagcg
     6121 tggccgtcgc accgccaaaa gatgcagtag agctcatgac catccacaag agtaaagggc
     6181 tggagtttcc ttacgtcttt atcctcaata tggatcaaga tttcaacaag caggactcta
     6241 tgtcagaagt cattctcagt cgtcagaatg gtcttggtgt caaatatatt gccaagatgg
     6301 agacaggggc agtagaagac cactatccta aaaccatcaa actctccatt cctagtctga
     6361 cctataggca gaacgaagag gaattacagc tagcaagcta ttctgagcag atgcgtttgc
     6421 tgtatgttgc tatgacgcgg gctgagaaaa agctctatct tgtcggcaag ggttctcgtg
     6481 aaaagctgga agctaagcaa tacccagcag ccaaaaatgg gaaactaaat agcaatacta
     6541 gactgcaagc acggaatttc caagattggc tttgggctat cagtaaagtg tttactaagg
     6601 acaagctcaa ctttagttat cgttttattg gcgaagatca gttgaccaga gaagctatcg
     6661 gagagttgga aaccaagagt cctctccaag atagctccca agcagacaat cgtcagtcag
     6721 ataccatcaa agaagctctg gaaatgctga aggaggtgga agtttataat actcttcacc
     6781 gcgcagctat tgaacttcct agtgttcaaa ccccaagtca aatcaagaaa ttctacgaac
     6841 cagttatgga tatggaaggt gtcgagattg ctggtcaagg tcagtcagta ggcaagaaaa
     6901 tcagcttcga tttgccagat ttttcaacca aagaaaaggt aactggagct gagattggta
     6961 gtgctactca cgaactcatg cagataattg acctcagcca gcaactaacc cttgctagcc
     7021 taacagaaac actcaaacaa gttcaaacta gccaagctgt cagagacaag atcaatcttg
     7081 ataaaattct tgctttcttt gacacagcac tcggtcagga aattcttgct aataccgacc
     7141 atctctatcg cgagcaacct ttctccatgc tcaaacgaga ccaaaagagt caggaagact
     7201 ttgttgtccg tggtatcctt gatggctatc tgctttacga aaacaaaatt gttctgttcg
     7261 actacaagac agaccgctat gatgaaccaa gtcaactcgt agaccgctat cgtggtcagt
     7321 tagctctata cgaagaggct ttatcacgag cctattcgat tgaaaatatt gaaaaatact
     7381 tgattttact cggtaaagac gaggttcaag ttgtaaaagt ataacttata ctcttcgaaa
     7441 atctcttcaa accacgtcag cttcgccttg ctgtatatat ggttactgac ttcgtcagtt
     7501 ctatccacaa cctcaaaaca gtgttttgag ctgacttcgt cagttctatc cacaacctca
     7561 aaacagtgtt ttgagctgac ttcgtcagtt ctatctacaa cctcaaaaca gtgttttgag
     7621 ctgactgcgg ctagctttct agtttgctct ttgattttta ttgagtatta gaaaggagac
     7681 ctcatgacac ttccagttag aaaatccctg cacgatgcag ttttacaggc ttcgaaagcg
     7741 gatacttggg aacaagctac caaggaatgg aatgaagttt ccttgatttt taacggtatt
     7801 ggccgtagca attgtgtctg tggaaatgcc atcaaatacg cttatgaact ctttaacggt
     7861 gtcacaggcc aacgcctctt tccaattggt agcgactgtg ttcgtcattt tcatcgattg
     7921 tcccttgacc agcaattgga agaggaagaa aaactgctca gaaaggttga aaatctaacc
     7981 agaaaagctc agaaaaagga aaaaatcaag gtcaataaaa gtgactttga cgagcgactt
     8041 ctaaaatggc tctgggaaaa aggtgttttc aaacccaatc gtggcaatca atttgcgcct
     8101 gagagagact accagctttt cctagaagtc tttcagggag gaagttggac caaggcggaa
     8161 ccaaagaaaa aggctcggat ggaagaagtc cttgaaaagt gtatcaaacc ctttttactt
     8221 gggaaatcgg atgaccaact ctaccttgtc aagctaggca aggagaaaat tgactacgaa
     8281 caagaactcc gtatccaggc agagaaagaa cgtaagaaga gggataaaat cgccaagcaa
     8341 tatgcagaca atctggttct agccatggga cccgcagagc gtgcttatca agattacttt
     8401 ggctttacag agaccctgac tcaagaagaa cgcaagtggg aaaaaattct ttttggtaaa
     8461 aatagagcag aacgggctat caaggccaaa caataccaaa aagagctgga aaaagaccaa
     8521 cgaattgcca gtcaggatcc aattgaaaga aaacagaagc agacttggct cctcaattcc
     8581 tattttcgtg agcttcctga agaaaaagct cgattttcta ggctcttatt agaatatcga
     8641 aaaaatggtg aagtaccctt ttcaactgaa tacctgtcag atcatctcat cgactttttc
     8701 tataaaatga aagcctttga atttgaaatc gcaccagaac aagtccgaga ttttctaaaa
     8761 aaaagcctgc aggaagacca tcgctcatca gcacaaggaa gctggataga aggaattctc
     8821 ctcaactgcc tcaaaccatt tttagaacga ttagtgatat gagtaacacc taccgtgtaa
     8881 atttcatggt aggtgttatt gtacccccaa ataatataaa acaaagtatg aaagcgcatc
     8941 tcaattttaa gacttttttg taaattaaga gtataattaa ggtatactgc cttttctata
     9001 gataatagat aatacactaa tataataaag gtctttgtaa catatataaa ttttatttca
     9061 aggaggaata atggaaaagt attttggtga aaaacaagag cgtttttcat ttagaaaatt
     9121 atcagtagga cttgtatctg caacgatttc aagtttattt tttatgtctg tattagctag
     9181 ttcatctgtg gatgctcaag aaactgcggg agttcactat aaatatgtgg cagattcaga
     9241 gctatcatca gaagaaaaga agcagcttgt ctatgatatt ccgacatacg tggagaatga
     9301 tgatgaaact tattatcttg tttataagtt aaattctcaa aatcaactgg cggaattacc
     9361 aaatactgga agcaagaatg agaggcaagc cctagttgct ggtgctagct tagctgctct
     9421 gggaatttta atttttgctg tttccaagaa aaaggttaag aataaaacgg tattacattt
     9481 agtattggtt gcaggaatag gaaatggtgt cttagtttca gtccatgctt tagaaaatca
     9541 tcttttgcta aattacaata cggactatga attgacctct ggagaaaaat tacctcttcc
     9601 taaagagatt tcaggttaca cttatattgg atatatcaaa gagggaaaaa cgacttctga
     9661 gtctgaagta agtaatcaaa agagttcagt tgccacttct acaaaacaac aaaaggtgga
     9721 ttataatgtt acaccaaatt ttgtagacca tccatcaaca gtacaagcta ttcaggaaca
     9781 aacacctgtt tcttcaacta agccgacaga agttcaagta gttgaaaaac ctttctctac
     9841 tgaattaatc aatccaagaa aagaagagaa acaatcttca gattctcaag aacaattagc
     9901 cgaacataag aatctagaaa cgaagaaaga ggagaagatt tctccaaaag aaaagactgg
     9961 ggtaaataca ttaaatccac aggatgaagt tttatcaggt caattgaaca aacctgaact
    10021 cttatatcgt gaggaaacta tagagacaaa aatagatttt caagaagaaa ttcaagaaaa
    10081 tcctgattta gctgaaggaa ctgtaagagt aaaacaagaa ggtaaattag gtaagaaagt
    10141 tgaaatcgtc agaatattct ctgtaaacaa ggaagaagtt tcgcgagaaa ttgtttcaac
    10201 ttcaacgact gcgcctagtc caagaatagt cgaaaaaggt actaaaaaaa ctcaagttat
    10261 aaaggaacaa cctgagactg gtgtagaaca taaggacgta cagtctggag ctattgttga
    10321 acccgcaatt cagcctgagt tgcccgaagc tgtagtaagt gataaaggcg aaccagcagt
    10381 ccaaccagag ctaccggaag cggttgtaac tgacaaaggt gagactgagg ttcaaccaga
    10441 gtcgccagat actgtggtaa gtgataaagg tgaaccagag caggtagccc cattgccaga
    10501 atatacaaga ccacaagcag gtgcagtagt tg
//
LOCUS       DAVLHC010000062        10511 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.063, whole genome shotgun sequence.
ACCESSION   DAVLHC010000062 DAVLHC010000000
VERSION     DAVLHC010000062.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10511)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10511)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10511
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.063"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            1..611
                     /locus_tag="VXE25_001850"
                     /pseudo
     CDS             1..611
                     /locus_tag="VXE25_001850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="frameshifted; internal stop; incomplete; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=2
                     /transl_table=11
                     /product="IS630 family transposase"
     gene            511..957
                     /locus_tag="VXE25_001851"
     CDS             511..957
                     /locus_tag="VXE25_001851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864098.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HEV0772264.1"
                     /translation="MRKHGLISKSTSKRYYQVAIPFTRLFCLVLVSIDYINCLSETTD
                     KNWHKSDRIFVTNTRKPAHSSILSKSLQRANERLKKPIPKHLSPHIFRHTTISILSEN
                     KIPLKTITDRVGHSDSEVTTSIYTHVTKNMKDEAINVLDKVMKKIF"
     gene            complement(1094..2398)
                     /gene="eno"
                     /locus_tag="VXE25_001852"
     CDS             complement(1094..2398)
                     /gene="eno"
                     /locus_tag="VXE25_001852"
                     /EC_number="4.2.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopyruvate hydratase"
                     /protein_id="HEV0772265.1"
                     /translation="MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTG
                     EHEAVELRDGDKSRYGGLGTQKAVDNVNNIIAEAIIGYDVRDQQAIDRAMIALDGTPN
                     KGKLGANAILGVSIAVARAAADYLEIPLYSYLGGFNTKVLPTPMMNIINGGSHSDAPI
                     AFQEFMILPVGAPTFKEALRYGAEIFHALKKILKSRGLETAVGDEGGFAPRFEGTEDG
                     VETILAAIEAAGYVPGKDVFIGFDCASSEFYDKERKVYDYTKFEGEGAAVRTSAEQID
                     YLEELVNKYPIITIEDGMDENDWDGWKALTERLGKKVQLVGDDFFVTNTDYLARGIQE
                     GAANSILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADIAVATNAGQ
                     IKTGSLSRTDRIAKYNQLLRIEDQLGEVAEYRGLKSFYNLKK"
     gene            2562..3008
                     /locus_tag="VXE25_001853"
     CDS             2562..3008
                     /locus_tag="VXE25_001853"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000131081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YueI family protein"
                     /protein_id="HEV0772266.1"
                     /translation="MTDLSKQLLEKAHGGLKINPDEQRRYLGTFEERVLGYVDIDTAN
                     SPQLEKGFLFILENLQEKAEPLFVKISPTIEFDKQVFYLKEAKETDSQATIVSEEHIT
                     SPFGLVIHSNAPVQVEEKDLRLAFPKLWEVKKEEPAKTSLWKKWFS"
     gene            complement(3005..4120)
                     /locus_tag="VXE25_001854"
     CDS             complement(3005..4120)
                     /locus_tag="VXE25_001854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000706318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerate kinase"
                     /protein_id="HEV0772267.1"
                     /translation="MKIVIAPDSFKESLTAQQVAEAIKRGFQQSIADVECLLCPVGDG
                     GEGTVDAIRHSLDLKEKWIQVTDPFGQKEAMRYFQKGELALFEVADLVGLGKIPLEKR
                     NPLQIQTCGIGELILHLISKGIKDIYIGVGGTASNDGGLGIAAGLGYQFYDRDGNVLP
                     VSGQSLLNLASVSTENCYKIPEGVQIHILADVVSPLCGHQGATYTFGNQKGLHPTMFA
                     VVDQAIQDFYEKFSPATLEIKGAGAGGGLAGGLCAFAQASIVSGIDTCLDLINFDKKV
                     SDADLVVVGEGILDSQSFAGKAPIGVAKRTPVGVPVIAICGSLAEDLPPLPFENIQAV
                     FSILEKSEPLEDSLKNASLYLERTAANIGHLLNMCKI"
     gene            complement(4129..4458)
                     /locus_tag="VXE25_001855"
     CDS             complement(4129..4458)
                     /locus_tag="VXE25_001855"
                     /inference="COORDINATES: protein motif:HMM:NF012905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD hydrolase family protein"
                     /protein_id="HEV0772268.1"
                     /translation="MERLAKSLGIAYFTANQLEVKEGLLTGKLVGQIISPQVKKETLE
                     KWRKKLKLSKERTVAIGDGVNNLLMLKSAELGIAFCAKEVLKKEIPHHVDKRDFLEVL
                     PLIDCLE"
     gene            complement(4403..4774)
                     /locus_tag="VXE25_001856"
     CDS             complement(4403..4774)
                     /locus_tag="VXE25_001856"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809343.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD-IB family phosphatase"
                     /protein_id="HEV0772269.1"
                     /translation="MSQVKGLCVLDVDGTLILEEVIDLLGREAGHEAEISQITSRAMR
                     GELVFESSLRKRVSLLEGLPILVFDNVFNSIHLSLNVPEFISILQKNGILVGLVSGGF
                     TPIVGEISKIPWYCLFHCQPA"
     gene            complement(4833..6266)
                     /gene="glgA"
                     /locus_tag="VXE25_001857"
     CDS             complement(4833..6266)
                     /gene="glgA"
                     /locus_tag="VXE25_001857"
                     /EC_number="2.4.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000697278.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycogen synthase GlgA"
                     /protein_id="HEV0772270.1"
                     /translation="MKILFVAAEGAPFSKTGGLGDVIGALPKSLVKAGHEVAVILPYY
                     DMVEAKFGNQIEDVLHFEVSVGWRRQYCGIKKTVLNGVTFYFIDNQYYFFRGHVYGDF
                     DDGERFAFFQLAAIEAMERIDFIPDLLHVHDYHTAMIPFLLKEKYRWIQAYEDIETVL
                     TIHNLEFQGQFSEGMLGDLFGVGLERYADGTLRWNNCLNWMKAGILYANRVSTVSPSY
                     AHEIMTSQFGCNLDQILKMESGKVSGIVNGIDADLYNPQTDALLDYHFNQEDLSGKAK
                     NKAKLQERVGLPVRADVPLVGIVSRLTRQKGFDVVVESLHHILQEDVQIVLLGTGDPA
                     FEGAFSWFAQIYPDKLSTNITFDVKLAQEIYAACDLFLMPSRFEPCGLSQMMAMRYGT
                     LPLVHEVGGLRDTVRAFNPIEGSGTGFSFDNLSPYWLNWTFQTALDLYRNHPDIWRNL
                     QKQAMESDFSWDTACKSYLDLYHSLVN"
     gene            complement(6263..7402)
                     /gene="glgD"
                     /locus_tag="VXE25_001858"
     CDS             complement(6263..7402)
                     /gene="glgD"
                     /locus_tag="VXE25_001858"
                     /EC_number="2.7.7.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate adenylyltransferase subunit
                     GlgD"
                     /protein_id="HEV0772271.1"
                     /translation="MKIDKYSAILGNTVGFHNMSTLTDHRPVASLPFGGKYRLIDFPL
                     SSLANAGVRSVFGIFQQDNISSVFDHIRSGREWGLSTLLSHYYLGIYNTRVESSTVGK
                     EYYQQLLTYLKRSGSNQTVALNCDVLINIDLNQVFHLHSTTKEPITVVYKKLAKKDIS
                     EVNAILDVDETDHVLSHKLFDSKSTAETFNMSTDIFVVDTPWLIEHLEEEAKKEHPEK
                     LRYVLRDLAVKEGAFAYEYTGYLANIHSVKSYYQANIDMLESQKFYSLFSPNQKIYTK
                     VKNEEPTYYANTSKVSTSQFASGSIIEGQVANSVLSRNIHVHKDSLVKDSLLFPRVVI
                     GEGAQVEYAILDKGVEVEPGVVIRGTAEHPVVVKKGAKVTEDIHS"
     gene            complement(7392..8534)
                     /locus_tag="VXE25_001859"
     CDS             complement(7392..8534)
                     /locus_tag="VXE25_001859"
                     /EC_number="2.7.7.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000787267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate adenylyltransferase"
                     /protein_id="HEV0772272.1"
                     /translation="MKNEMLALILAGGQGTRLGKLTQSIAKPAVQFGGRYRIIDFALS
                     NCANSGIHNVGVVTQYQPLALNNHIGNGSSWGLDGINSGVSILQPYSASEGNRWFEGT
                     SHAIYQNIDYIDSVNPEYVLILSGDHIYKMDYDDMLQSHKDNNASLTVAVLDVPLKEA
                     SRFGIMNTDANNRIVEFEEKPAQPKSTKASMGIYIFDWQRLRNMLVAAEKSKVGMSDF
                     GKNVIPNYLESGESVYAYEFSGYWKDVGTIESLWEANMEYISPENALDSRNRQWKIYS
                     RNLISPPNFLGANAHVEDSLVVDGCFVDGTVKHSILSTGAQVREGAEVLDSVIMSGAI
                     IGQGAKIKRAIIGEGAIISDGVEIDGTDEVQVVGYNEVVGVATDED"
     gene            complement(8524..10452)
                     /gene="glgB"
                     /locus_tag="VXE25_001860"
     CDS             complement(8524..10452)
                     /gene="glgB"
                     /locus_tag="VXE25_001860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1,4-alpha-glucan branching protein GlgB"
                     /protein_id="HEV0772273.1"
                     /translation="MDNREALKTFMTGENFYLQHYLGAHREELNGEHGYTFRVWAPNA
                     QAVHLVGDFTNWIENQIPMVRNDFGVWEVFTNMAQEGHIYKYHVTRQNGHQLMKIDPF
                     AVRYEARPGTGAILTELPEKKWKDGLWLARRKRWGFEERPVNIYEVHAGSWKRNSDGS
                     PYSFAQLKDELIPYLVEMNYTHIEFMPLMSHPLGLSWGYQLMGYFALEHAYGRPEEFQ
                     DFVEECHTHNIGVIVDWVPGHFTINDDALAYYDGTPTFEYQDHNKAHNHGWGALNFDL
                     GKNEVQSFLISCIKHWIDVYHLDGIRVDAVSNMLYLDYDDAPWTPNKDGGNLNYEGYY
                     FLQRLNEVIKLEYPDVMMIAEESSSATKITGMKEIGGLGFDYKWNMGWMNDILRFYEE
                     DPIYRKYDFNLVTFSFMYVFKENYLLPFSHDEVVHGKKSMMHKMWGDRYNQFAGLRNL
                     YTYQICHPGKKLLFMGSEYGQFLEWKSEEQLEWSNLEDPMNAKMKYFTSQLNQFYKDH
                     RCLWEIDTSYDGIEIIDADNRDQSVLSFIRKGKKGEMLVCIFNMVPVERKNFTIGLPV
                     AGIYEEVWNTELEEWGGVWKEHNQTVQTQEGLWKDYEQTLTFTLPAMGASVWKIKRRL
                     KSTKTVTNKNPKGVENEK"
BASE COUNT         3186 a         2320 c         1874 g         3131 t
ORIGIN      
        1 aatagcttct gactttggct gtcatccaac taccatccac tatgcgctca aagctatggg
       61 ctacactcga aaaaaagaac cacacctact atgaacaaga cccagaaaaa gtagccttat
      121 ttcttaagaa ttttaatagt ttaaagcacc tagcacctgt ttagattgac gaaacaggat
      181 tcgatactta tttttatcga gaatatggtc gctcattaaa agatcagtta ataagaggca
      241 aagtatctgg aagaagatat cagaggattt ctttggttgc aggtctaaca aatggtgagt
      301 taatcgctcc aatgacttac gaagagacga tgacgagcga cttttttgaa gcttggtttc
      361 agaaatttct cttaccaaca ttaaccacac catcggttat tattatggat aatgcaagat
      421 tccatagaat ggggaatcta gaacttttat gcgaagagtt tgggcataaa cttttacctc
      481 ttcctcccta ctcgcctgag tacaatccta ttgagaaaac atgggctcat atcaaaaagc
      541 acctcaaaaa ggtattacca agttgcaata ccttttacga ggctcttttg tcttgttctt
      601 gtttcaattg actatataaa ttgtctaagc gaaacaaccg ataagaattg gcacaaaagc
      661 gaccgtattt ttgttaccaa tacaagaaaa ccagctcata gttctatctt gagtaagtct
      721 ctccagcgag caaacgaacg ccttaaaaaa ccaattccca aacatctgtc ccctcacatc
      781 ttcagacaca ccactattag catcttatca gaaaataaaa ttcctttaaa aacaatcacg
      841 gacagggttg gtcattccga ctctgaagtc actacttcca tctacaccca cgtcacaaag
      901 aacatgaaag atgaagcaat caatgtactg gataaagtta tgaaaaagat tttttaaaag
      961 ttttgtccct tttttgtcct ctaaatacaa aaatagccct tcggataaaa tccgaggggc
     1021 tagaaacgtt gttaaatcaa cggccgaact tttgaatttc atggttcggg ataaaatagt
     1081 tcactgaact attttatttt ttaaggttgt agaatgattt caatccacga tattcagcta
     1141 cttcaccaag ttggtcttcg atacgaagca attggttgta tttagcgata cggtctgtac
     1201 gtgaaagtga accagtcttg atttgtcctg cgttagttgc aactgcgata tcagcgattg
     1261 ttgaatcttc agtttcacct gaacggtgtg atacaacagc agtgtaacca gcttctttag
     1321 ccatttcgat agcttcaaaa gtttcagtaa gagtaccgat ttggttaact ttgataagga
     1381 ttgagttagc agcaccttct tggataccac gtgcaaggta gtcagtgttt gttacgaaga
     1441 agtcgtcacc aacaagttgt actttcttac caagacgttc agtaagagct ttccaaccat
     1501 cccagtcgtt ttcatccata ccatcttcaa tagtgatgat tgggtatttg ttaaccaatt
     1561 cttcaaggta gtcgatttgt tctgcagatg tacgaacagc agcaccttca ccttcaaatt
     1621 tagtgtagtc gtaaacttta cgttctttat cgtagaattc tgatgaagca cagtcaaatc
     1681 cgataaatac gtctttacct ggtacatatc cagcagcttc aatcgcagca aggatagttt
     1741 caacaccatc ttcagttcct tcgaaacgag gagcgaatcc accttcgtca cctacggcag
     1801 tttccaaacc acgtgattta aggattttct taagagcgtg gaagatttca gcaccgtaac
     1861 gaagggcttc tttaaatgtt ggcgcaccaa ctggcaagat catgaactct tggaaagcga
     1921 ttggagcgtc agagtgagaa ccaccgttga tgatgttcat cattggagtt ggaagaactt
     1981 tagtgttgaa tccaccaagg tagctgtaaa gtgggatttc aaggtagtca gcagcagcac
     2041 gagctacagc gatagacaca ccgaggattg cattcgcacc caatttacct ttgttaggag
     2101 taccgtcaag tgcgatcata gcacggtcaa tagcttgttg atcacgtaca tcgtagccaa
     2161 tgatagcttc agcaatgatg ttgtttacgt tgtcaacagc tttttgtgta ccaagaccac
     2221 cgtaacgaga tttgtcaccg tcgcgaagtt caactgcttc gtgttcacca gtagaagctc
     2281 ctgatggaac cataccacgt ccgaaagcac ctgattcagt gtaaacttct acttcaagtg
     2341 ttgggttacc gcgtgagtct aggacttcgc gagcgtaaac atcagtaata attgacattt
     2401 tttactctcc ttatgagtta aattttttac acctctataa taccttaaaa cccctccttt
     2461 ttcaagaaaa aacgttatct ttgtgcaact tttccttaac tttataaagt aatcgctttc
     2521 ttttgtctgt tttattctaa cttttatgat atactgtttt catgacagat ttatcaaaac
     2581 aattacttga aaaagctcat ggtgggttaa aaataaatcc ggatgagcaa agacgctatc
     2641 ttggtacttt tgaggaaaga gttcttggat atgtagatat tgacacagca aatagccctc
     2701 agttagaaaa aggcttttta tttattttag aaaaccttca ggaaaaagca gagccactat
     2761 ttgtgaagat ttcaccaact atcgaatttg ataagcaagt tttctactta aaagaagcaa
     2821 aagaaactga tagtcaagcc accatagtat ctgaagagca tattacttct cctttcggcc
     2881 tggttattca tagcaatgca ccagttcaag tagaagaaaa agaccttcga cttgcttttc
     2941 caaaactttg ggaagttaaa aaggaagaac cagccaaaac atccttatgg aagaaatggt
     3001 ttagctaaat cttgcacata tttaataagt gcccaatatt ggcagccgtg cgctccagat
     3061 agagactggc atttttcaaa ctatcttcta aaggttcact tttctccaaa atagaaaaga
     3121 cagcttggat attttcaaat ggtaggggag gtaaatcttc agcaagacta ccgcaaatag
     3181 caataacagg aactccaaca ggggttcttt ttgcaacacc tataggcgct ttcccagcaa
     3241 agctttgact gtcaagtatt ccttctccaa caacaaccaa gtcagcatct gaaactttct
     3301 tatcaaagtt gattaagtcc aagcaggtat caattccaga cacgatactt gcctgagcaa
     3361 aggcacacaa accaccagca aggcctccac ctgctcctgc tcctttaatt tctaatgttg
     3421 caggtgagaa tttttcataa aaatcttgga tcgcctgatc tacgactgca aacatagtcg
     3481 gatgtagacc tttttgattg ccaaaagtgt aagtcgcacc ttgatgacca cataagggac
     3541 tcacgacatc tgctagaata tgaatttgaa caccttcagg aattttatag caattttctg
     3601 ttgaaacaga agctaagttt aataaggatt gaccggaaac aggcaagaca tttccatccc
     3661 tatcataaaa ttgataacct aaaccagcag caatccccag tcctccatca ttactggccg
     3721 tgccaccaac accgatataa atatctttaa tccctttaga aatgagatgg agaatcaact
     3781 ctccaatacc acaagtttgg atttgaagtg gatttcgttt ctctagcgga atttttccaa
     3841 gaccaaccaa gtcagctact tcaaatagtg ccagttcccc tttttgaaaa tagcgcatgg
     3901 cttctttttg tccaaaaggg tctgtcactt ggatccattt ttcttttagg tcaagagaat
     3961 gtcggatagc atctacagta ccttctcccc catcaccaac agggcagagg agacattcta
     4021 catctgctat cgattgttgg aagcctcttt ttattgcttc agctacctgt tgagctgtca
     4081 agctttcctt aaacgaatcc ggtgcaatta caatcttcat attttccctc attctaaaca
     4141 gtcaatcaaa ggaagaactt ctaaaaaatc cctcttgtca acatgatgtg gtatttcttt
     4201 tttgagcact tctttggcac aaaaggcgat tcctaactcc gccgacttca acattaatag
     4261 attattgacc ccatcaccga ttgccaccgt tctttcttta gaaagtttta gtttctttct
     4321 ccatttttcc agagtttctt ttttgacctg gggacttata atttgtccaa ctaattttcc
     4381 tgttaaaaga ccttctttga cttcaagctg gttggcagtg aaataggcaa taccaaggga
     4441 ttttgctaat ctctccaact attggtgtaa atccaccaga caccagacca actaggatgc
     4501 cattcttttg gagaatagag atgaactctg ggacatttag cgatagatga attgagttga
     4561 agacgttatc aaagaccaaa ataggaagac cttccaacaa ggacactctt tttcttaaac
     4621 tgctttcaaa gaccaactct cctcgcattg ctcgacttgt aatctgcgaa atttccgcct
     4681 catgacctgc ctctctccct aaaagatcaa tcacttcttc taggattaag gttccatcta
     4741 catccaaaac acacaagcct tttacttgag acatcagttc tcctctctaa acagcctaaa
     4801 aatcgtatga agtcatcata cgattttatc tattaattaa ctaaactatg gtacaagtca
     4861 aggtatgact tgcaggctgt atcccatgag aagtcactct ccatagcttg tttttgtagg
     4921 tttctccaaa tgtctggatg gtttctatac aagtccaatg ctgtttggaa agtccaattt
     4981 aaccaataag gagatagatt gtcaaagcta aagccagtac cgcttccttc gattggattg
     5041 aaagcgcgaa ctgtatctcg caagcctcca acttcatgga ccaatggcaa ggttccataa
     5101 cgcatagcca tcatttgaga caagccacac ggttcaaaac gacttggcat gaggaagagg
     5161 tcacaagcag cgtagatttc ctgagcaagt ttgacatcaa aagtgatatt tgttgatagc
     5221 ttgtctgggt aaatctgagc aaaccatgag aaagctcctt caaaggctgg atcgccagtt
     5281 cccaaaagaa caatctgaac atcttcttgc aagatatggt gaagactttc gaccaccaca
     5341 tcaaaacctt tttgacgtgt caaacgagaa acaattccca ccagtggaac gtctgctcta
     5401 acaggcaagc caactctttc ttgcaatttt gccttatttt tggctttccc agacaaatct
     5461 tcctgattga aatgatagtc taaaagagca tccgtctgag gattataaag atcagcatca
     5521 atcccattca cgataccaga tactttacca gactccattt taagaatctg atccaaatta
     5581 catccaaact gactagtcat aatttcatga gcatagctag gtgaaacggt tgaaacacgg
     5641 ttcgcataga gaatacctgc cttcatccag ttcagacagt tgttccatcg aagggtgcca
     5701 tcagcgtaac gttcaaggcc aactccaaac aaatcaccca acattccttc tgaaaattgt
     5761 ccttggaatt ctaaattatg aatggttaaa actgtttcaa tgtcctcata ggcttgaatc
     5821 caacggtatt tttccttcaa caagaaagga atcatagctg tatggtagtc atgaacatgg
     5881 agaagatcag gaataaagtc aatcctttcc atagcctcaa tggcagccag ttggaaaaag
     5941 gcaaagcgtt ctccgtcatc aaaatcaccg taaacatgac cacggaagaa ataatattga
     6001 ttgtcaataa agtagaaggt tacaccattt aatactgttt tcttaattcc acaatactgt
     6061 ctgcgccaac caacgctcac ctcaaaatga agcacatctt caatctgatt tccaaattta
     6121 gcctctacca tatcatagta gggtaaaatc actgcaactt cgtgcccagc ttttaccagt
     6181 gattttggaa gagcgccaat gacgtctccc aaaccacctg tttttgaaaa gggtgcaccc
     6241 tctgctgcta caaataaaat tttcatgaat gaatatcctc tgttacttta gcacctttct
     6301 taaccacaac tggatgttct gcagttcctc gaatcacaac accaggctca acttcaaccc
     6361 ctttgtccaa gatagcatat tcgacctgag ccccttctcc aataacaaca cgagggaaga
     6421 gcaggctatc tttaaccaag ctatccttat ggacatgaat attacgtgat agaacagaat
     6481 tagctacttg accttcaata atactaccag aggcaaactg agaagtgctt accttagatg
     6541 tattagcata gtaagttggc tcttcgtttt tgacctttgt ataaatcttt tggtttggtg
     6601 agaaaagaga atagaatttt tgtgattcaa gcatatcgat attcgcttga taataagatt
     6661 taacagagtg aatattggct agatagcccg tgtactcgta ggcgaaagct ccctctttta
     6721 cagccaaatc ccgtaaaaca tagcgcaatt tctctggatg ttctttttta gcttcttctt
     6781 ccaagtgttc aatcaaccaa ggtgtatcaa cgacaaagat atctgtagac atattgaacg
     6841 tttcagctgt tgacttgcta tcaaagagtt tatgagaaag aacatggtct gtttcatcta
     6901 catccaagat tgcatttact tctgaaatat ctttcttagc tagtttttta taaactacag
     6961 tgataggctc ttttgttgta ctatgtaggt ggaaaacttg gttcaaatca atgttaataa
     7021 gaacatcgca gttgagggca accgtttggt ttgagccaga acgtttcaaa taagtaagaa
     7081 gctgttggta gtattctttt ccaactgtac tactttctac acgggtattg taaattccta
     7141 gatagtaatg gctaagaagg gttgataagc cccactcgcg tcctgaacga atatggtcaa
     7201 atactgagct gatattatcc tgctggaaaa taccaaagac actacgaaca cctgcattag
     7261 caaggcttga aagtgggaag tcaatcaaac gatatttccc accaaatggc aaacttgcta
     7321 ctggacggtg gtccgtcaat gtcgacatat tgtgaaaacc aactgtattt cctaaaatgg
     7381 cagaatattt atcaatcttc atctgttgct acccccacta cttcattata tcctacaact
     7441 tgtacttcat ctgttccatc aatttcgaca ccgtcagaaa taatcgcacc ttcaccaata
     7501 atggcacgtt taatcttagc tccttgacca atgatagctc cactcatgat aactgaatca
     7561 aggacttccg ctccttcgcg aacttgcgcg cctgttgaaa ggatagaatg tttaacagtt
     7621 ccatcaacga aacatccgtc tacaactaat gagtcttcca catgagcatt tgccccgagg
     7681 aagtttggtg gtgaaatcaa gtttcttgag taaatcttcc attgacggtt acgactatcc
     7741 aaggcatttt ctggagaaat atactccatg ttcgcttccc aaagtgactc aatagtacca
     7801 acatctttcc aataaccact aaattcgtaa gcataaacac tttcacctga ctcaaggtaa
     7861 tttggaatga catttttacc aaagtctgac atgccaacct tgctcttttc agcagcgact
     7921 aacatattac gaaggcgttg ccaatcaaaa atgtagattc ccatagaagc ttttgtagat
     7981 ttaggttgag ctggtttttc ttcaaattca acaatacgat tgttagcatc tgtgttcatg
     8041 ataccaaaac ggcttgcttc tttaagaggg acgtctaaaa ctgctactgt caagctggca
     8101 ttattatcct tatgagactg gagcatatca tcatagtcca ttttgtagat gtggtcccca
     8161 gacaaaatca agacatactc aggattgaca ctgtcgatat agtcgatatt ttggtaaata
     8221 gcgtgactag ttccctcaaa ccaacgattt ccttcacttg cagaataagg ttgaagaata
     8281 gagacacctg aattaatacc gtctagtccc cagcttgaac cattcccaat atggttgttg
     8341 agagcaagtg gttgatactg tgtaacgacc ccaacattat gaatccctga gttggcacag
     8401 tttgataggg caaagtcaat gatacggtag cgcccaccaa attgcacagc tggttttgcg
     8461 atgctttgag tgagtttacc gagacgagtt ccttgcccac cagcaagaat caaagctaac
     8521 atttcatttt tcattttcta ctccttttgg gtttttattt gtgacggttt tagtagattt
     8581 caagcgacgt ttgattttcc atacacttgc tcccatagcc ggtagggtaa aggttaaggt
     8641 ctgctcataa tctttccata gtccttcttg cgtttgaaca gtttgattat gttctttcca
     8701 aacgcctccc cactcttcca actcagtatt ccatacttct tcgtaaattc ctgcaacggg
     8761 tagtccgatt gtaaaatttt tccgctcaac aggtaccatg ttaaagatac agactaacat
     8821 ttctcccttt ttacccttac gaataaagga aagaacactc tggtctcgat tatccgcatc
     8881 aatgatttca ataccatcat agctggtatc gatttcccac agacagcgat gatctttgta
     8941 aaactggttt agctgagaag tgaaatactt catcttagca ttcattgggt cttctaggtt
     9001 agaccattcc aactgttctt cagatttcca ttctaggaat tgaccgtatt cgctacccat
     9061 gaagagcaat ttcttaccag ggtgacaaat ttggtacgta tagagattgc gcaagcctgc
     9121 gaattgattg taacgatctc cccacatctt atgcatcata ctcttcttgc catgaaccac
     9181 ttcatcgtgc gagaatggca agagataatt ctccttgaaa acatacataa agctgaaagt
     9241 caccaggtta aagtcatatt tacgataaat cggatcttct tcgtagaaac ggaggatatc
     9301 attcatccag cccatgttcc atttgtagtc aaatcctaga ccaccaatct ctttcattcc
     9361 cgtaatcttg gttgcagacg aactttcttc tgcaatcatc atcacatctg gatattctaa
     9421 cttaataact tcattcaagc gttgaaggaa ataataacct tcatagttga gatttccgcc
     9481 atctttatta ggtgtccatg gagcatcatc atagtccaaa tagagcatgt tgctaacagc
     9541 atccacacga ataccatcca aatgatagac atcaatccaa tgcttaatgc aagaaattaa
     9601 gaaggactgg acttcatttt ttccaaggtc aaaattaagg gcaccccaac catggttatg
     9661 agccttatta tggtcttggt attcaaaagt cggtgtccca tcataataag ctaaggcatc
     9721 atcgttgatg gtaaagtgac ctggtaccca gtccacaata accccaatat tatgggtatg
     9781 acactcctcg acaaaatctt gaaactcctc tggtcggcca taagcatgct ctaaagcgaa
     9841 gtaacccata agctgatacc cccaactcaa gcccaaagga tgggacatca agggcataaa
     9901 ctcaatatga gtatagttca tttcaacgag ataaggaatg agttcatcct tgagctgggc
     9961 aaaactataa ggactgccat cagaatttct tttccatgat ccagcgtgaa cttcataaat
    10021 attgacagga cgctcttcaa agccccaacg ttttcttcgt gccagccaaa gtccatcctt
    10081 ccatttcttc tcaggaagct ctgttaagat tgcccctgtt cctggacgag cctcatatct
    10141 gacagcaaaa gggtcaatct tcatcagttg atgaccattt tgacgtgtga catgatattt
    10201 gtaaatatgc ccttcttgag ccatattggt aaagacttcc cagaccccaa aatcatttct
    10261 taccattgga atctgatttt caatccagtt ggtaaaatca ccaaccaagt gaacagcctg
    10321 agcattaggt gcccaaacac ggaaggtata gccatgctct ccatttagtt cttccctatg
    10381 tgctcctaga taatgttgga gataaaaatt ttcacccgtc ataaaggttt ttaatgcttc
    10441 tctattatcc atatactccc cttctcctgt aagcgttttc tatgctttta ttatactacc
    10501 tttttagaga a
//
LOCUS       DAVLHC010000063        10280 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.064, whole genome shotgun sequence.
ACCESSION   DAVLHC010000063 DAVLHC010000000
VERSION     DAVLHC010000063.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10280)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10280)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10280
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.064"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            141..3242
                     /locus_tag="VXE25_001861"
     CDS             141..3242
                     /locus_tag="VXE25_001861"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000561528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit alpha"
                     /protein_id="HEV0772274.1"
                     /translation="MIAQLDTKTVYSFMESVISIEKYVRAAKEYGYTHLAMMDIDNLY
                     GAFDFLEITKKYGIHPLLGLEMTVFVDDQGVNLRFLALSSVGYQQLMKLSTAKMQGEK
                     TWSVLSQYLEDIAVIVPYFDRVESLELGCDYYIGVYPETLASEFHHPILPLYRVNAFE
                     SRDREVLQVLTAIKENLPLREVPLRSRQDVFISASSLEKLFQERFPQALDNLEKLISG
                     ISYDLDTSLKLPRFNPARPAVEELRERAELGLVQKGLTSKEYQDRLDQELSVIHDMGF
                     DDYFLVVWDLLRFGQSNGYYMGMGRGSAVGSLVSYALDITGIDPVEKNLIFERFLNRE
                     RYTMPDIDIDIPDIYRPDFIRYVGNKYGSKHAAQIVTFSTFGAKQALRDVLKRFGVPE
                     YELSAITKKISFRDNLKSAYEGNLQFRQQINSKLEYQKAFEIACKIEGYPRQTSVHAA
                     GVVISDQDLTNYIPLKYGDEIPLTQYDAHGVEASGLLKMDFLGLRNLTFVQKMQELLA
                     ETEGIHLKIEEIDLEDKETLALFASGNTKGIFQFEQPGAIRLLKRVQPVCFEDVVATT
                     SLNRPGASDYINNFVARKHGQEEVTVLDPVLEDILAPTYGIMLYQEQVMQVAQRLAGF
                     SLGKADILRRAMGKKDASAMHEMRASFIQGSLEAGHTVEKAEQVFDVMEKFAGYGFNR
                     SHAYAYSALAFQLAYFKTHYPAIFYQVMLNSSNSDYLIDALEAGFEVASLSINTIPYH
                     DKIANKAIYLGLKSIKGVSNDLALWIIENRPYSNIEDFIAKLPENYLKLPLLEPLVKV
                     GLFDSFEKNRQKVFNNLANLFEFVKELGSLFGDAIYSWQESEDWTEQEKFYMEQELLG
                     IGVSKHPLQAIASKAIYPITPIGNLSENSYAIILVEVQKIKVIRTKKGENMAFLQADD
                     SKKKLDVTLFSDLYRQVGQEIKEGAFYYVKGKIQSRDGRLQMIAQEIREAVAERFWIQ
                     VKNHESDQEISRILEQFKGPIPVIIRYEEEQKTIVSPHHFVAKSNELEEKLNEIVMKT
                     IYR"
     gene            3324..4331
                     /gene="pfkA"
                     /locus_tag="VXE25_001862"
     CDS             3324..4331
                     /gene="pfkA"
                     /locus_tag="VXE25_001862"
                     /EC_number="2.7.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000820836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phosphofructokinase"
                     /protein_id="HEV0772275.1"
                     /translation="MKRIAVLTSGGDAPGMNAAIRAVVRQAISEGMEVFGIYDGYAGM
                     VAGEIHPLDAASVGDIISRGGTFLHSARYPEFAQLEGQLKGIEQLKKHGIEGVVVIGG
                     DGSYHGAMRLTEHGFPAIGLPGTIDNDIVGTDFTIGFDTAVTTAMDAIDKIRDTSSSH
                     RRTFVIEVMGRNAGDIALWAGIATGADEIIIPEAGFKMEDIVASIKAGYECGKKHNII
                     VLAEGVMSAAEFGQKLKEAGDTSDLRVTELGHIQRGGSPTARDRVLASRMGAHAVKLL
                     KEGIGGVAVGIRNEKMVENPILGTAEEGALFSLTAEGKIVVNNPHKADIELSSLNKSL
                     S"
     gene            4390..5895
                     /gene="pyk"
                     /locus_tag="VXE25_001863"
     CDS             4390..5895
                     /gene="pyk"
                     /locus_tag="VXE25_001863"
                     /EC_number="2.7.1.40"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate kinase"
                     /protein_id="HEV0772276.1"
                     /translation="MNKRVKIVATLGPAVEIRGGKKFGEDGYWGEKLDVEASAKNIAK
                     LIEAGANTFRFNFSHGDHQEQGERMATVKLAEKIAGKKVGFLLDTKGPEIRTELFEGE
                     AKEYSYKTGEKIRVATKQGIKSTREVIALNVAGALDIYDDVEVGRQVLVDDGKLGLRV
                     VAKDDATREFEVEVENDGIIAKQKGVNIPNTKIPFPALAERDNDDIRFGLEQGINFIA
                     ISFVRTAKDVNEVRAICEETGNGHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMG
                     IEVPFEMVPVYQKMIIKKVNAAGKVVITATNMLETMTEKPRATRSEVSDVFNAVIDGT
                     DATMLSGESANGKYPLESVTTMATIDKNAQALLNEYGRLDSDSFERNSKTEVMASAVK
                     DATSSMDIKLVVTLTKTGHTARLISKYRPNADILALTFDELTERGLMLNWGVIPMLTD
                     APSSTDDMFEIAERKAVEAGLVESGDDIVIVAGVPVGEAVRTNTMRIRTVR"
     gene            complement(6170..6418)
                     /locus_tag="VXE25_001864"
     CDS             complement(6170..6418)
                     /locus_tag="VXE25_001864"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001167984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HEV0772277.1"
                     /translation="MQKANTKLEKPINQPLSSHIFRHTLLSTLAEKNAIMVRVEHKNA
                     KTVNNIYTHVSKRMEQATLEVLNTISLNRKYIRSNLDK"
     gene            complement(6585..6810)
                     /locus_tag="VXE25_001865"
                     /pseudo
     CDS             complement(6585..6810)
                     /locus_tag="VXE25_001865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001838792.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
     gene            7658..8530
                     /locus_tag="VXE25_001866"
     CDS             7658..8530
                     /locus_tag="VXE25_001866"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000749590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4300 family protein"
                     /protein_id="HEV0772278.1"
                     /translation="MKKSRKLATLGICSALFLGLAACQQQHVTSEGTNQRQSSSAKVP
                     WKASYTNLNNQVSTEEVKSLLSAHLDPNSVDAFFNLVNDYNTIVGSTGLSGDFTSFTH
                     TEYDVEKISHLWNQKKGDFVGTNCRINSYCLLKNSVTIPKLEKNDQLLFLDNDAIDKG
                     KVFDSQDKEEFDILFSRVPTEATTDVKVHAEKMETFFSQFQFNEKARMLSVVLHDNLD
                     GEYLFVGHVGVLVPADDGFLFVEKLTFEEPYQAIKFASKEDCYKYLGTKYADYTGEGL
                     AKPFIMDNDKWVKL"
     gene            complement(8676..9020)
                     /locus_tag="VXE25_001867"
                     /pseudo
     CDS             complement(8676..9020)
                     /locus_tag="VXE25_001867"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
     gene            9163..9474
                     /locus_tag="VXE25_001868"
     CDS             9163..9474
                     /locus_tag="VXE25_001868"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521917.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772279.1"
                     /translation="MELKDFTEKEQEMIKKRLTMSNISDKETTEKILALVPQDLIKRI
                     PFFVRKHATTRTIKRISIEHPELYAVAQTSGEIPEKEREELRQIITTIFEQKMNKHSI
                     K"
     gene            9478..10194
                     /locus_tag="VXE25_001869"
     CDS             9478..10194
                     /locus_tag="VXE25_001869"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000759776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HEV0772280.1"
                     /translation="MKKYFIGGLGSNAYHSKDFLQELDSQVYFLNPYEKHLRDETELK
                     SWFKNEIVEEESICLIGHSIGGDLARYFASEFEEVKKLILLDGGYLDLDKILPLDTEL
                     EETKNYIKSQIISDLDVLTSKEKSEAKHWSENMEKAVRQSYHWNVEYNRYELAINYEN
                     IEAILRLRRKIQAFKREVGDTLFISPRYPNEATWREEALKELPDYFDTIFLENFGHEL
                     YTQAPKEIASLMNEWLAYFL"
BASE COUNT         3213 a         1775 c         2173 g         3119 t
ORIGIN      
        1 atagtataaa tataaaaatg atgacaaaaa tacaaatgaa tagaaaataa attagtaagc
       61 tgatgaaatt tttctcaaga gaagccattt ataggtgaaa atggtataat atagtgagaa
      121 ggatagagga gaagtgtaaa ttgatcgcac aactagatac aaaaacagtc tatagtttta
      181 tggaaagcgt catttcgatc gaaaagtatg tgagagcagc taaagaatac ggctacactc
      241 atttggctat gatggatatt gacaatcttt atggcgcttt cgactttcta gagattacaa
      301 aaaaatacgg cattcatcct ttgctagggc ttgaaatgac agtgtttgta gatgatcagg
      361 gagtgaattt gcgcttttta gctctatcta gtgtgggcta tcagcagttg atgaagcttt
      421 cgacagccaa gatgcagggg gagaaaactt ggtcagtcct gtcccagtac ctggaggata
      481 tcgcggtcat tgtgccttat tttgatagag ttgagtcgtt agaactaggc tgtgattact
      541 atataggggt ttatccagaa acactagcaa gcgaatttca tcatcctatc ttacctcttt
      601 atcgggtcaa cgcttttgaa agcagggata gagaagttct tcaagtttta acagcgatta
      661 aagaaaatct accgctcaga gaagttccct tgcgttcgag acaagatgtc tttatatcag
      721 caagttcttt agagaaacta ttccaagagc gttttccgca agctttggac aatttagaaa
      781 agcttatttc aggcatttct tacgacttgg atactagtct gaaactgcct cgttttaatc
      841 cagctagacc agcagtagag gagttgagag agcgtgctga actggggctt gttcagaagg
      901 ggttgactag taaagaatat caagatagac tagaccaaga attgtctgtt attcatgata
      961 tgggctttga tgattatttc ttggttgttt gggatttgtt gcgttttgga caatcgaatg
     1021 gctattatat gggaatggga aggggttctg cagtaggcag tttggtttct tatgccttag
     1081 acatcacggg gattgaccca gtagagaaaa atctgatttt tgaacgcttt cttaatcgtg
     1141 aacgctatac catgcctgat attgatattg atatcccaga tatttatcgt ccagatttta
     1201 tcagatatgt tggtaataaa tatggtagta aacatgcggc acaaatcgtt actttttcaa
     1261 cctttggagc caagcaagct cttcgagatg tcttgaaacg ctttggtgtg ccagagtatg
     1321 aattatctgc aattactaag aaaatcagtt ttcgtgacaa tcttaagtcg gcctatgagg
     1381 gcaatctcca gtttcgtcag caaatcaata gtaagttaga ataccaaaaa gcttttgaga
     1441 ttgcttgcaa gatagagggc tatccaaggc aaacctctgt ccatgcggct ggtgttgtaa
     1501 ttagtgacca agatttaacc aactacattc ctctaaagta tggtgatgaa attccactga
     1561 ctcagtatga tgctcatgga gttgaggcta gcggactttt gaagatggac tttctgggac
     1621 tacgaaattt gacctttgtc cagaagatgc aagagttgct tgctgaaaca gaaggtattc
     1681 atctgaaaat tgaagaaatc gatttagaag acaaagaaac gttagcttta tttgcctctg
     1741 gtaatacaaa aggtatcttt caatttgagc aaccaggtgc cattcgtctg cttaagcgtg
     1801 tgcaaccagt ctgttttgaa gatgtcgtcg cgactacttc tctaaatcga ccgggtgcta
     1861 gtgactatat caataatttt gtggcaagaa agcatgggca ggaagaagtg actgttctgg
     1921 atccagtact ggaggatatt ttggctccaa cctacggcat aatgctctat caggagcagg
     1981 ttatgcaggt tgcccagcga cttgccggat ttagtcttgg gaaagccgat attttgcgtc
     2041 gggctatggg gaaaaaggat gcctctgcca tgcatgagat gagggcttcc tttattcaag
     2101 gttcattaga agctggtcat actgtggaaa aagcagagca ggtctttgat gttatggaga
     2161 agtttgcagg ttatggtttt aacaggtcac acgcctatgc ctactcagcc ttggccttcc
     2221 agttggctta tttcaaaacg cattatccag ccatttttta tcaggtcatg ttaaattctt
     2281 ccaacagtga ttacttaata gatgcacttg aagcaggttt tgaagtagcc tctctatcca
     2341 tcaacaccat tccctatcac gataaaattg ccaacaaggc catctatcta ggtttgaaat
     2401 ccattaaagg agtcagtaat gatttagctc tctggattat tgaaaataga ccttattcta
     2461 acattgaaga ttttatagct aaattacctg agaattatct gaaacttcct ctgctagaac
     2521 ctttggtaaa agttggtctt ttcgattcat ttgaaaaaaa tcgtcaaaaa gtatttaata
     2581 acttagctaa tctatttgaa tttgtgaaag agttgggaag tttgtttgga gatgctattt
     2641 atagttggca ggaatcggaa gattggacgg aacaagaaaa attttatatg gaacaagagc
     2701 ttttagggat aggtgtcagc aaacatccac tacaagctat tgcaagtaag gctatttacc
     2761 cgattacccc aatcggaaat ttgtcagaaa atagctatgc tattatcttg gttgaagttc
     2821 agaaaataaa agtgattcgt accaaaaagg gtgaaaatat ggccttctta caggcagatg
     2881 atagtaagaa aaaattggat gtcactctct tttcagactt atatcgtcag gttggacagg
     2941 aaataaaaga gggagccttc tactatgtaa aaggaaaaat acaatcacgt gatggccgtc
     3001 tgcaaatgat tgcacaagaa ataagagaag cagttgctga acgcttttgg atacaggtga
     3061 aaaatcatga atcggatcaa gaaatttcac gcattttaga acaatttaaa ggcccaatcc
     3121 cagtcatcat ccggtatgaa gaggaacaga aaaccatcgt ttctccccat cattttgtag
     3181 ctaaatccaa tgaattagag gagaaattga atgaaatcgt tatgaaaacg atttatcgct
     3241 aaaaatacgg aaaatagaag aattttcaac gtaaatgtgg tataatcagt aagaatgtta
     3301 aaagaaaaag gagcataacc aatatgaaac gtattgctgt tttgactagt ggtggagacg
     3361 cccctggtat gaacgctgcc atccgtgcag ttgttcgtca agcaatttca gaaggaatgg
     3421 aagtttttgg tatctatgac ggatatgctg gtatggttgc cggtgaaatt catcccctag
     3481 atgcagcttc agtaggggac atcatttctc gtggtggtac tttccttcac tcagctcgtt
     3541 acccagagtt cgctcaactt gaagggcaac ttaaagggat tgagcaattg aaaaaacacg
     3601 gaattgaagg tgtagttgtt atcggtggtg acggatctta ccacggcgct atgcgtttga
     3661 ctgaacatgg cttcccagct attggtcttc caggtacaat cgataacgat atcgttggta
     3721 ctgactttac aatcggtttt gacacagcgg ttactactgc catggacgct atcgataaga
     3781 ttcgtgatac atcatcaagt caccgtcgta cttttgtaat cgaagttatg ggacgtaacg
     3841 ctggtgatat cgctctttgg gctggtattg caactggtgc tgatgaaatc atcatccctg
     3901 aagcaggctt caagatggaa gatatcgtag caagcatcaa agctggttat gaatgtggta
     3961 aaaaacacaa tatcatcgtc ttagctgaag gtgtgatgtc agcggctgaa tttggtcaaa
     4021 aacttaaaga agctggagat acaagcgacc ttcgtgtaac agaacttgga catattcaac
     4081 gtggtggttc tccaactgcg cgtgaccgtg ttttggcgtc acgtatgggt gcacatgctg
     4141 ttaaacttct taaagaaggt atcggtggtg ttgcggttgg tattcgtaac gaaaaaatgg
     4201 ttgaaaatcc aattcttggt actgcagaag aaggggcatt gtttagcctt actgcagaag
     4261 gtaagattgt ggttaacaac ccacacaaag ccgatattga gctatctagc ttgaataaga
     4321 gcttgtcata atttacaatt tagttaataa gaccaaaaag gtcatatata taaaggagtc
     4381 acaaaaatca tgaacaaacg tgtaaaaatc gttgcaactt tgggtcctgc ggtagaaatc
     4441 cgtggtggta aaaaattcgg tgaggacgga tactggggtg aaaaacttga tgttgaagct
     4501 tcagctaaaa acattgctaa attgattgaa gctggtgcta acacattccg attcaacttc
     4561 tcacacggcg accaccaaga acaaggtgag cgtatggcaa ctgttaaact tgcggaaaaa
     4621 attgcaggta aaaaagttgg tttccttctt gatacaaaag gacctgaaat ccgtacagaa
     4681 ttgttcgaag gtgaagctaa agaatattca tacaaaactg gtgaaaaaat tcgtgttgca
     4741 actaaacaag gaatcaaatc aactcgtgaa gtgattgcgt tgaacgttgc tggtgctctt
     4801 gatatctatg atgatgttga agttggtcgt caagttttgg ttgacgatgg taaacttggt
     4861 cttcgtgtgg ttgctaaaga tgatgcaact cgtgaatttg aagttgaagt tgaaaacgat
     4921 ggtatcatcg ctaaacaaaa aggtgtgaac atccctaaca ctaaaattcc tttcccagct
     4981 cttgctgaac gcgataacga cgatatccgt ttcggtcttg aacaaggtat caacttcatc
     5041 gcaatttcat tcgtacgtac tgcaaaagat gtgaacgaag ttcgtgcaat ctgtgaagaa
     5101 actggaaacg gacatgttca attgttcgct aaaatcgaaa accaacaagg tatcgataac
     5161 ttagacgaaa tcatcgaagc agctgatggt attatgattg ctcgtggtga tatgggtatc
     5221 gaagtaccgt tcgaaatggt tccagtttat caaaaaatga ttatcaagaa agtcaatgct
     5281 gcaggtaaag ttgttatcac tgcaacaaac atgcttgaaa caatgactga aaaaccacgt
     5341 gcaactcgtt cagaagtatc agacgtattc aacgctgtta tcgacggaac tgacgctaca
     5401 atgctgtcag gcgagtctgc aaacggtaaa tacccactcg agtcagtaac tacaatggct
     5461 acaatcgaca agaacgctca agctcttctt aatgaatacg gacgtcttga ttcagattca
     5521 tttgagcgta actctaagac agaagtaatg gcttctgctg ttaaagatgc tactagctca
     5581 atggatatca aattggttgt aactcttact aagacaggtc atactgcacg tttgatttct
     5641 aaataccgtc caaatgctga catcttagca ttgacatttg acgaattgac agaacgtggc
     5701 ttgatgttga actggggtgt tatcccaatg ttgacagatg ctccatcttc aactgacgat
     5761 atgttcgaaa tcgctgaacg taaagcggta gaagcaggtc tcgttgagtc aggcgatgat
     5821 atcgttatcg ttgctggtgt gccagtagga gaagctgttc gcacaaacac aatgcgtatc
     5881 cgcacagtac gttaagaaaa atataaaaac ctatcatatc cagctttcta gcctgtatga
     5941 tgggctcttt ttttgtccag ggggcaaaaa gggggcaaaa ctttcataat ggattgatac
     6001 tcttcgaaaa tcaaattcaa accacgtcag cgtcgcctta ccgtactcaa gtacagcttg
     6061 cggctagctt cctagtttgc tctttgattt tcattgagta tgaaataaga tatgcacaaa
     6121 ttgattagaa agtcaaatga atttctacaa atgttttagc aatcgcaatc tacttgtcta
     6181 gattcgatct gatatatttt cgatttaatg atatggtatt taaaacctcc aaagtagctt
     6241 gctccattct tttacttacg tgagtgtaga tgttatttac tgttttagcg tttttgtgtt
     6301 ccactctaac cattatagca ttcttctcag ctagtgtact aaggagtgtg tgcctgaaaa
     6361 tatgggaact aaggggctgg tttatcggtt tctctagttt agtatttgcc ttttgcaaag
     6421 tgatcttaaa tgcctttctc taaatttaca tatcactatt gtttaacaaa atctaatcta
     6481 ctttaggtca cttattcttt ttttgaaatg tagaatgaac tttttcaaag tttttcgaat
     6541 cttttaaaat ctgtttgttt tatatcgcca ttctcccccc ttttttaatt ctccctatat
     6601 agcctgacaa ctttcccgat ggtacgaata tggttgcttt cgtctaggtg gatgtcgggg
     6661 tattcgggat tgagtttttt tgaggtagcc ttggcggagt ttcttgacat agttagcgcc
     6721 gtctacttgg aagatgccga tggtattata gtcaatctgt ggggtattct tgataaatag
     6781 gtagtcgctg tttcttatct ttggctccat ggacttgctg acgacataag cgattgggtc
     6841 gtagtcgtct gggataatgg aaactccata actaaatcgt cgtcctgcat cgagcggcta
     6901 cctgcagaga taaactacct aacacgagag taagtagtct gtctgtagtc gtccagtctg
     6961 atgattttta cgatacttcg tttttctgat catacagttg cctctcggca taggtcagaa
     7021 ctttaccttg tctgggtggt gcccgttggt cgtagataga ttggatatcg ctaggagaat
     7081 ccttttgaac tggaggaaag agggcatcaa tcaagctact gaatacttta actaagtcaa
     7141 atatagtatt tttcttagta gacctaaccc ttttttcata atttctaatg gtgtttttac
     7201 ttatacctat cttagtaccc aattcttatt gagtccaacc attactagtc tatattgttt
     7261 tatagttgat ttagtttgga atagtacgct gtagctgcta aaacatttct aggaattaat
     7321 ttgcctttcc taatagagtt gttcatatct tatttcaatc tactatattt ttcacctcta
     7381 acaatcgcaa tctcttcttt atccatgaat aaaaacgatt tctatttttg taagtaaagc
     7441 atcacacgaa atccacgaaa atgaaaacct ttgttgtgtt ttcgtaaaaa atttgttgac
     7501 agagcacgaa acgcctacta taattaaatc aagtttaagg aaataacaaa aaaacaaatc
     7561 ggagggaaag acgatgaaca cattaaatga gaaagtaatc aatatctgta aagcagtagt
     7621 taaagaaact ttaatccaag acatttagga gaaagaaatg aagaaatcaa gaaaattagc
     7681 cacattagga atctgttcag ctttgttttt aggcttggct gcttgtcaac aacaacatgt
     7741 tacttctgag gggacgaatc aaaggcaaag cagttcagcg aaagttccat ggaaagcttc
     7801 atacaccaac ctaaacaacc aggtaagtac agaagaggtc aaatctctct tatcagctca
     7861 cttggatcca aatagtgttg atgcattttt taatctcgtt aatgactata ataccattgt
     7921 cggctcaact ggcttatcag gagatttcac ttcctttact cacaccgaat acgatgttga
     7981 gaaaatcagt catctctgga atcaaaagaa gggcgatttc gttgggacca actgccgtat
     8041 caatagttat tgtcttttga aaaattcagt caccattcca aagcttgaaa agaatgacca
     8101 attgcttttc ctagataacg atgcgattga taaaggaaag gtctttgatt cacaagataa
     8161 ggaagagttt gatattctat tttcgagagt tccaactgag gcaactacag atgtcaaggt
     8221 tcacgctgaa aagatggaaa cattcttctc acaatttcaa ttcaatgaaa aagctcgaat
     8281 gctgtctgta gtcttgcacg acaatctgga tggcgagtat ctgtttgtag gccacgttgg
     8341 ggtcttagta cctgctgatg acggtttctt atttgtagag aaattgactt tcgaagagcc
     8401 ctaccaagcg attaaatttg ctagtaagga agattgctac aagtatttgg gcaccaagta
     8461 tgcggattat acaggcgagg gactggctaa gccttttatc atggataatg ataagtgggt
     8521 taaactttaa tagtgttatg atatgacagt aatcttagga tttttatttc tatttttgat
     8581 gacttggtgg gttatttcaa tcgttaatag ccagaaacca cgcaaaaatg aaacatttat
     8641 tggctatatc caaagatacg atattgatgg gaatggctat caatcattac cgtgtcctca
     8701 gaactgagag gagttcttga aatcgtaaaa ctactttgaa caagagttac ttcaacccat
     8761 tggctccgac ggattaagtt gctttcgtga acaccaaaat cagccgcaat ttcttcataa
     8821 gtgcggtatt ctcgcacata ttgaagagtg gccataagaa ggtcttctag gcttaattta
     8881 ggttttcgtc ccccttttgt gtgtttaagt tgataagcag tttttaatac agctaacatc
     8941 tcttcaaaag tggtgcgctg aacaccaaca agacatttaa atcgtgcatc agttagttgc
     9001 ttacttgctt cataattcat agaactacta taccatattt tgtttcgcag gaagtctaat
     9061 gctaaaatct tatcagtgag aagatttctt aaagtttatt ctttgtagtt tcatctgtat
     9121 tagtatataa tttaacttag agaaaatagg aggactaatc gaatggaatt aaaagatttt
     9181 acagaaaaag aacaggaaat gattaagaaa aggcttacaa tgtctaatat tagtgacaaa
     9241 gaaactactg agaagattct ggcgctagta ccacaagact tgattaagcg aatcccgttt
     9301 tttgtcagaa aacatgctac aacacgtacg attaaacgca tttcaattga acaccctgaa
     9361 ctctacgctg tagctcaaac aagtggtgag attccagaaa aagaacgcga agaattgcgt
     9421 cagattatca caactatctt tgaacaaaag atgaataagc atagtattaa gtagagaatg
     9481 aaaaaatatt ttattggcgg tttgggaagc aatgcctatc atagcaagga ttttcttcaa
     9541 gaactagatt cgcaggtcta ttttctaaat ccatatgaaa agcatcttcg agatgaaaca
     9601 gaattgaaat catggtttaa aaatgagatt gtagaggaag aatctatctg tctgataggt
     9661 cattctattg gaggcgattt agctcgttat ttcgcatcgg aatttgaaga agtaaagaaa
     9721 ctgattcttt tggatggtgg ctatctagat ttagataaga ttttaccttt ggatacagag
     9781 ttagaggaaa ctaaaaatta tatcaaatct caaattattt cggacttaga tgttcttact
     9841 tctaaagaaa aatctgaagc aaagcattgg tcagaaaata tggagaaagc tgtaagacag
     9901 tcctatcact ggaatgttga gtataataga tatgagttgg ctataaatta tgaaaatata
     9961 gaagcgatac tccgcctacg gagaaaaata caagctttta agagagaagt gggagatacc
    10021 ttgtttatta gtcctcgcta tcctaatgaa gctacatgga gagaggaagc cctaaaagaa
    10081 ttgccagact attttgatac tattttttta gaaaactttg gccatgagct ttatactcaa
    10141 gcacctaaag aaatcgctag tctaatgaat gagtggctcg cttattttct atgagctact
    10201 tgtattgctg gaaatggtat aagatgaaaa tctacaagtc actaattttc atataaccaa
    10261 aaaacgaaca ggctcttttt
//
LOCUS       DAVLHC010000064        10122 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.065, whole genome shotgun sequence.
ACCESSION   DAVLHC010000064 DAVLHC010000000
VERSION     DAVLHC010000064.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10122)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10122)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10122
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.065"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(<1..93)
                     /locus_tag="VXE25_001870"
     CDS             complement(<1..93)
                     /locus_tag="VXE25_001870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEV0772281.1"
                     /translation="MKLNYDDKVQIYELRKQGYSLEKLSNKFGIN"
     gene            371..466
                     /locus_tag="VXE25_001871"
                     /pseudo
     CDS             371..466
                     /locus_tag="VXE25_001871"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(719..1339)
                     /locus_tag="VXE25_001872"
     CDS             complement(719..1339)
                     /locus_tag="VXE25_001872"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000780815.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HEV0772282.1"
                     /translation="MKLYFVRHGRTLWNQEGRFQGASGDSPLLPESIETLKRLGQYLK
                     EIPFDQIYSSDLPRAVKSAEIIQSQLHTPCSLEIVPNLREWQLGKLEGLKIATLEAIY
                     PQQIQAFRSNLAQFDTRMFGAESLYSTTQRTIQFIKSLKDSPAERILIVGHGANLTAS
                     LRTLLGYKEPLLRKDGGLANASLTIIETHDFETFTLNTWNDTSYQS"
     gene            complement(1339..1821)
                     /locus_tag="VXE25_001873"
     CDS             complement(1339..1821)
                     /locus_tag="VXE25_001873"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397917.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoacyl-tRNA deacylase"
                     /protein_id="HEV0772283.1"
                     /translation="MAKKVKIKKTLVEQILSKAAIPHQGIQINALEGELPQGYERDQI
                     FKTLALLGDKTGPIIGIIPITQHLSEKKLAKISGNKKVSMIPQKDLEKTTGYIHGANN
                     PVGIRQKHNYPIFIDKIALDLDQMIVSAGEVGHSIIVAPQDLASFVKADFVDILEDIK
                     "
     gene            complement(1821..2663)
                     /locus_tag="VXE25_001874"
     CDS             complement(1821..2663)
                     /locus_tag="VXE25_001874"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF368 domain-containing protein"
                     /protein_id="HEV0772284.1"
                     /translation="MLSWLARVIKGIVIALGFILPGISGGVLAAILGIYERMIGFLAH
                     PFKDFKENVLYFIPVAIGMLLGIGLFSYPIEYLLENYQVFVLWSFAGAIIGTVPSLLK
                     ESTRESDRDKIDLAWLWTTFIISGLGLYALNFVVGTLSASFLNFVLAGALLALGVLVP
                     GLSPSNLLLILGLYAPMLTGFKTFDLLGTFFPIGIGAGATLIVFSKLMDYALNNYHSR
                     VYHFIIGIVLSSTLLILIPNAGNAESIQYTGLSLVGYVIIAFFFALGIWLGIWMSQLE
                     DKYK"
     gene            complement(2758..3546)
                     /locus_tag="VXE25_001875"
     CDS             complement(2758..3546)
                     /locus_tag="VXE25_001875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 25 protein"
                     /protein_id="HEV0772285.1"
                     /translation="MRKQIHPLILFSFFGIMMFILIINRPLNDSQSFKTKSNIAQALK
                     HLDKPIIDLSGWQHPEEINYDALSQNISGAIVRVHSGAQTTKENDASFINGIDKAYKS
                     HITELQKRNVPVAVYAYVAGKSVQEMEKAAEVFYNAASPYSPSYYWLDVEDKTMSNMN
                     EGVENFRAKLASLGAKNIGIYVGVYFMEEHSIDTGKFTSVWIPSYGSDSGFLESSPKT
                     DLDYDIHQYTSKGKIAGFDHDLDINVISPLKNKEETFRKLFLKP"
     gene            3700..5079
                     /gene="glmU"
                     /locus_tag="VXE25_001876"
     CDS             3700..5079
                     /gene="glmU"
                     /locus_tag="VXE25_001876"
                     /EC_number="2.3.1.157"
                     /EC_number="2.7.7.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000073762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional UDP-N-acetylglucosamine
                     diphosphorylase/glucosamine-1-phosphate
                     N-acetyltransferase GlmU"
                     /protein_id="HEV0772286.1"
                     /translation="MSNFAIILAAGKGTRMKSDLPKVLHKVAGISMLEHVFRSVGAIQ
                     PEKTVTVVGHKAELVEEVLAGQTEFVTQSEQLGTGHAVMMTEPILEGLSGHTLVIAGD
                     TPLITGESLKNLIDFHINHKNVATILTAETDNPFGYGRIVRNDNAEVLRIVEQKDATD
                     FEKQIKEINTGTYVFDNERLFEALKNINTNNAQGEYYITDVIGIFRETGEKVGAYTLK
                     DFDESLGVNDRVALATAESVMRRRINHKHMVNGVSFVNPEATYIDIDVEIAPEVQIEA
                     NVTLKGQTKIGAETVLTNGTYVVDSTIGAGAVITNSMIEESSVADGVTVGPYAHIRPN
                     SSLGAQVHIGNFVEVKGSSIGENTKAGHLTYIGNCEVGSNVNFGAGTITVNYDGKNKY
                     KTVIGDNVFVGSNSTIIAPVELGDNSLVGAGSTITKDVPADAIAIGRGRQINKDEYAT
                     RLPHHPKNQ"
     gene            5089..5634
                     /locus_tag="VXE25_001877"
     CDS             5089..5634
                     /locus_tag="VXE25_001877"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000393791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HEV0772287.1"
                     /translation="MEFEEKTLSRKEIYQGPIFKLVQDQVELPEGKGTAQRDLIFHNG
                     AVCVLAVTDEQKLILVKQYRKAIEAVSYEIPAGKLEVGENTAPVAAALRELEEETAYT
                     GKLELLYDFYSAIGFCNEKLKLYLASDLTKVENPRPQDENETLEVLEVSLEEAKELIQ
                     SGRICDAKTIMAVQYWELQKK"
     gene            5646..5960
                     /locus_tag="VXE25_001878"
     CDS             5646..5960
                     /locus_tag="VXE25_001878"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000517865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="foldase"
                     /protein_id="HEV0772288.1"
                     /translation="MGKSLLTDEMIERANRGEKISGPPLLDDNEETKILPTSSSRFGY
                     ANPKDHGFSQETLKIQVEPSIHKSRRIENTKRNVFNSKLNKILFAVIFLLILLVLAMK
                     LL"
     gene            5977..6669
                     /locus_tag="VXE25_001879"
     CDS             5977..6669
                     /locus_tag="VXE25_001879"
                     /EC_number="3.2.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5'-methylthioadenosine/adenosylhomocysteine
                     nucleosidase"
                     /protein_id="HEV0772289.1"
                     /translation="MKIGIIAAMPEELAYLVQHLDNAQEQVVLGNTYHTGTIASHEVV
                     LVESGIGKVMSAMSVAILADHFQVDALINTGSAGAVAEGIAVGDVVIADKLAYHDVDV
                     TAFGYAYGQMAQQPLYFESDKTFVAQIQESLSQLDQNWHLGLIATGDSFVAGNDKIEA
                     IKSHFPEVLAVEMEGAAIAQAAHALNLPVLVIRAMSDNANHEANIFFDEFIIEAGRRS
                     AQVLLAFLKALD"
     gene            6746..7237
                     /gene="rocS"
                     /locus_tag="VXE25_001880"
     CDS             6746..7237
                     /gene="rocS"
                     /locus_tag="VXE25_001880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000021242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosome segregation protein RocS"
                     /protein_id="HEV0772290.1"
                     /translation="MSIEMTVSEIAEVLGLSRQAINNRVKELPEEDTDKNDKGVTVVT
                     RSGLIKLEEIYKKTIFEDEPVSEDVKQRELMEILVDEKNAEILRLYEQLKAKDRQLSE
                     KDEQMRIKDRQIAEKDKQLDQQQQLTLQAMKDQENLKLELDQAKEEVQSTKKGFFARL
                     FGG"
     gene            7335..7925
                     /locus_tag="VXE25_001881"
     CDS             7335..7925
                     /locus_tag="VXE25_001881"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399240.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3'-5' exonuclease"
                     /protein_id="HEV0772291.1"
                     /translation="MERLEDYIAFDLEFNQHEGQTHLIQASAVRFRDGREIDAYDSYV
                     HTSVPLKSFINGLTGITAETLKDAPPVEKVLEEFQEFVGSLLMIGYNAAKSDLPILAE
                     HGLDYSQQYKVDLYDEAFERRSSDLHGIANLKLQTVASFLGFQGQSHNSLEDARMTAR
                     VYESFLESDQARELLETESSLSNNPFGGLDLSQLFD"
     gene            7934..9697
                     /locus_tag="VXE25_001882"
     CDS             7934..9697
                     /locus_tag="VXE25_001882"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerophosphodiester phosphodiesterase"
                     /protein_id="HEV0772292.1"
                     /translation="MKPEKPKKLGLKQIYLNLDKILFLFFLIFMIVEYLWVPFNSWLA
                     SFLLDQTGYLFISYNNVLAILTHSPLISLAFLALIVINLLVAYFQIGLLFIGARHLLY
                     NEKRRLIEYIRKVFHESFGFMKKLTCAKALFIFFYIAMLFPFIRKMLKIYYLNKIVIP
                     EFIQAYLEDKYWMWWLSILLLSLIFLYVSVRLMFALPKIVYDQLTVREAVMFSLEKTK
                     KRVTFYAWNLFYILLKAHLLFYLPLIPLLLAQTLVDDITQRESLILGILNFVVIKNLY
                     YMALTYFLVKFVSFLTGKELDMLPRREKDHIVRWGVMTCASLFFALEGYIYLEAPMVH
                     LPQLISHRGVSNANGIQNTVESLETTAQLKPDLVETDVQETKDGQFVMMHDANLKNLA
                     GINKSPQDLNLEELKGIDIFENGYQTKISSFEDYLSRANELGQKLLIEIKTSKKDSPD
                     MMNRFLARYAAKLKIYGHQIQSLDYHVVEKVRQYDAELPVYFIMPYNSVFPKTRATGY
                     TMEYSTLDEYFVSKLWTTDQKLYVWTVNDSEAISKSLHLGVDGVITDDLEKVQREIEV
                     AQEDPEYTDLLLKKALEFFEF"
     gene            9911..>10122
                     /locus_tag="VXE25_001883"
     CDS             9911..>10122
                     /locus_tag="VXE25_001883"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEV0772293.1"
                     /translation="MAYSIDFRKKVLSYCERTGSITEASHVFQISRNTIYGWLKLKEK
                     TGELNHQVKGTKPRKVDRDRLKNYLT"
BASE COUNT         3159 a         1747 c         2133 g         3083 t
ORIGIN      
        1 gtttatccca aatttatttg aaagcttctc taagctatat ccttgttttc taagttcata
       61 gatctgaact ttatcatcat aattcaattt cataataaaa acaccccaaa agttagattt
      121 tttctgtcta acttttgggg tgtagttcat gtacacctga tatgatgcgt tttataattt
      181 taaagacttt ttgaccagcc tcatttttta acttgatact cagtgaaaag caaagattaa
      241 actaggaagc tagctgtagg ctgctcaaag aacagctttg aggttgcaga taaaacttgt
      301 gaggtaacca acatatataa tgtgaagctg acgtggtttg aatagatttt aggagggtat
      361 gagtctggaa gttttaatgg ataatgcaag attccataga atgggtaagc tagagttctt
      421 atgtgaagag tttgggcata aacttttacc ttttcctccc tactcatctt agtatagaaa
      481 agtgaatctg aaatagtaca taactgcttc taaaacattc ttataaattg atttaaattc
      541 tcaaatcata ttattcagtt cttatttcat tttgctctac aatcctgttg agaagacacg
      601 tgttcatatc aaaaaggtat tggcaagttg caataccttt ttacaaggtt cttttgtctt
      661 atttttgttt caactgacta tatctcctat ggttctagtt cagaaggcta ggctataatt
      721 atgattgata agaagtatca ttccaagtat tgagagtgaa tgtttcaaaa tcatgggttt
      781 ctataatggt caggctggca tttgctagac cgccatcttt acgaagaagt ggttctttat
      841 agcctaggag agtacgaaga ctggcagtaa gattggcgcc gtgtccgaca attagaatac
      901 gctcagctgg actatctttt aatgatttga taaattggat ggtccgctga gttgtactat
      961 agagggattc ggctccgaac attcgagtgt caaattgagc aagatttgaa cgaaaagcct
     1021 ggatttgttg cgggtaaata gcttccaggg ttgcaatttt caaaccttct aacttcccaa
     1081 gttgccattc acggagatta ggaacgattt ctaaagaaca gggggtatgg agttgacttt
     1141 ggataatctc agcagatttg accgctcgag gtaaatcact tgaataaatc tgatcaaaag
     1201 gaatttcctt gagatactgg ccaagtcgtt ttagggtttc aatggattca ggaagaagag
     1261 gagaatcacc actagcacct tgaaaacgac cttcttggtt ccagagggta cgaccgtggc
     1321 ggacaaagta gagtttcatt acttgatgtc ctccaaaata tctacaaagt ctgcctttac
     1381 aaagctagcc aagtcttgtg gcgcgacgat aatgctgtgt ccgacttcgc ctgcagagac
     1441 aatcatttga tccaaatcta gagcaatttt atcgataaaa atgggataat tgtgtttctg
     1501 acgaattccg acaggattat tggctccatg aatgtaacca gttgtttttt ctaagtcctt
     1561 ttgtggaatc atgctcactt ttttattgcc agaaatttta gctagtttct tttcagacaa
     1621 gtgctgagtg atagggataa ttccgataat cggtccggtc ttgtctccca aaagcgccaa
     1681 ggttttgaaa atctgatctc gttcataacc ttgaggaagc tctccttcta gggcattgat
     1741 ttgaatcccc tgatgaggga tagctgcttt agataggatt tgttccacca atgttttttt
     1801 gattttaact ttttttgcca ttatttatat ttatcctcca attgactcat ccaaatacca
     1861 agccagattc ccagcgcaaa gaagaaggcg atgatgacat aaccgacaag tgaaagtcct
     1921 gtgtattgga tactttcagc gtttcctgca tttggaatta agatcaaaag ggtacttgat
     1981 aggacgatac cgatgatgaa atgatagacg cgtgagtggt agttgtttaa ggcataatcc
     2041 atcaattttg aaaaaacgat gagagttgca cctgcaccaa ttccaatcgg aaagaaggtt
     2101 cccaagagat caaaagtttt aaaaccagtc aacataggag catagagtcc caaaatcaaa
     2161 agtaaatttg atggactgag gccaggaacc aagacgccaa gggccaatag tgcgcctgct
     2221 aggacgaagt taagaaagct ggcgcttaag gttccaacga caaaatttaa ggcatagagt
     2281 cctaatccag aaatgataaa ggttgtccat aaccaagcta aatcaatctt gtctcggtca
     2341 gattctcgag ttgattcttt gaggaggcta ggaactgtac cgataatagc tcccgcaaag
     2401 ctccataata caaaaacctg ataattttca agcaggtatt caatcgggta ggaaaataag
     2461 ccgattccca gaagcatacc gatggcaact ggaataaagt acaaaacatt ttctttaaag
     2521 tctttaaagg gatgggccag aaagccaatc attcgttcat agattcctaa gattgctgct
     2581 agaacccctc cggaaattcc cggtaggata aatccaagag caattacaat ccctttaata
     2641 acgcgtgcta accatgagag catatatttc ctccaactat ttctatttca aaaaatcctt
     2701 actatattgt atcacaatca gacacaaaaa gaaaaagcaa atgataaaca aatgctttta
     2761 aggttttaaa aaaagttttc gaaaggtttc ttctttattt tttaagggag agataacgtt
     2821 gatatctaaa tcgtggtcaa agccggcaat ttttccttta gatgtgtatt ggtgaatatc
     2881 ataatctaaa tcagttttag gactgctctc caaaaatcct gagtctgagc cgtaggacgg
     2941 aatccaaaca gaggtaaact tgcctgtatc aatactgtgt tcttccatga agtagacacc
     3001 aacgtagatg ccgatgtttt tagcacctag tgatgctagt tttgctcgaa agttttcgac
     3061 accttcgttc atattagaca tggttttgtc ttccacgtca agccaatagt aactagggct
     3121 gtaaggagag gcagcattgt agaaaacttc ggcagccttt tccatttctt ggacactttt
     3181 tccagctaca taagcgtaga cagcaactgg gacattccgc ttttgaagtt cagtgatatg
     3241 actcttatag gccttgtcta ttccattgat aaatgaagca tcattttctt ttgttgtttg
     3301 agcaccactg tgaacacgaa caatagcacc tgaaatattt tgtgagaggg catcgtagtt
     3361 gatttcctca ggatgctgcc agccagagag gtcaataatc ggtttgtcta agtgtttcaa
     3421 agcctgtgct atattggatt ttgttttaaa cgattggctg tcattaagtg ggcgattgat
     3481 gattaaaatg aacatcataa tcccaaaaaa actaaataaa ataagtggat gaatttgttt
     3541 tctcatatct tataagtcta ccctaaaaat caaaaaaaat caaaaaaaat caaaaaaatg
     3601 ggttaaggaa gagactttag agcatttttt cattcaagag tgcggaatga tttgaaatat
     3661 ggtataataa aagggaattt ctacagaaaa gagaagatta tgtcaaattt tgccattatt
     3721 ttagcagcgg gtaaagggac tcgcatgaaa tctgatttgc caaaagtttt gcacaaggtt
     3781 gcgggtattt ctatgttgga acatgttttc cgtagtgtgg gagctatcca acctgaaaag
     3841 acagtaacag ttgtaggaca caaggcagaa ttggttgagg aggtcttggc tggacagaca
     3901 gaatttgtga ctcaatctga acagttggga actggtcatg cagttatgat gacagaacct
     3961 atcttagaag gtttgtcagg acacaccttg gtcattgcag gagatactcc tttaatcact
     4021 ggtgaaagct tgaaaaactt gattgatttc catatcaatc ataaaaatgt ggccactatc
     4081 ttgactgctg aaacggataa tccttttggc tatggacgaa ttgttcgtaa tgacaatgct
     4141 gaggttcttc gtattgttga gcagaaggat gctacagatt ttgaaaagca aatcaaggaa
     4201 atcaacactg gaacatacgt ctttgacaac gagcgtttgt ttgaggcttt gaaaaatatc
     4261 aataccaata acgctcaagg cgaatactat attacagacg tcattggtat tttccgtgaa
     4321 actggtgaaa aagttggcgc ttatactttg aaagattttg atgaaagtct tggggtaaat
     4381 gaccgtgtgg cgcttgcgac agctgagtca gttatgcgtc gtcgcatcaa tcataaacac
     4441 atggtcaacg gtgttagctt tgtcaatcca gaagcaactt atatcgatat tgatgttgag
     4501 attgctccgg aagttcaaat cgaagccaat gttaccttga aagggcaaac gaaaattggt
     4561 gctgagactg ttttgacaaa tggtacttat gtagtggaca gcactatcgg agcaggagcg
     4621 gtcattacca attctatgat tgaggaaagt agtgttgcag acggtgtgac agtcggtcct
     4681 tatgctcaca ttcgtccaaa ttcaagtctg ggtgcccaag ttcatattgg taactttgtt
     4741 gaggtgaaag gatcttcaat cggtgagaat accaaggctg gtcatttgac ttatatcgga
     4801 aactgtgaag tgggaagcaa cgttaatttc ggtgctggaa ctattacagt caactatgac
     4861 ggcaaaaaca aatacaagac agtcattgga gacaatgtct ttgttggttc aaattcaacc
     4921 attattgcac cagtagaact tggtgacaat tccctcgttg gtgctggttc aactattact
     4981 aaagacgtgc cagcagatgc tattgctatt ggtcgcggtc gtcagatcaa taaagacgaa
     5041 tatgcaacac gtcttcctca tcatcctaag aaccagtagg agcctatcat ggagtttgaa
     5101 gaaaaaacgc ttagccgaaa agaaatctat caaggaccaa tatttaaact ggtccaagat
     5161 caggttgaat taccagaagg caagggaact gcccaacggg atttgatttt ccacaatggg
     5221 gctgtctgtg ttttagcagt aacggatgaa caaaaactta tcttggtcaa gcagtaccgc
     5281 aaagctatcg aggctgtctc ttacgaaatt ccagccggaa aattggaagt aggagaaaac
     5341 acagcccctg tggcagctgc ccttcgtgaa ttagaggaag aaacagccta tacagggaaa
     5401 ttagaactct tgtacgattt ttattcagct attggctttt gtaatgagaa gttaaaacta
     5461 tatttagcaa gcgatttaac aaaagtggaa aatccgcgtc cgcaggatga gaatgaaacc
     5521 ttggaagtcc ttgaagtgag cttagaagaa gcgaaagaat taatccaatc aggtcgtatt
     5581 tgtgatgcca agacaattat ggctgttcag tattgggagt tgcagaaaaa atagaggagg
     5641 tcagtatggg taaatcttta ttaacggatg aaatgattga aagagctaat agaggcgaaa
     5701 aaatttcagg tcctcctttg ctagatgata atgaggaaac taagatttta ccaacctctt
     5761 cttcccgttt tggttatgcc aatcctaagg atcatggttt tagccaggaa accttgaaga
     5821 ttcaggtcga accatctatt cataaaagcc gtcgtattga aaataccaag agaaatgtct
     5881 tcaattctaa gttgaataaa atcttatttg cggtcatctt tctcttgatt ttgcttgttt
     5941 tagcaatgaa acttttgtaa tagaaaagga attgaaatga aaataggaat tattgctgct
     6001 atgccggaag aactggctta tctggtccag catttagata atgcccagga gcaagttgtt
     6061 ttggggaata cctatcatac aggaaccatt gcttctcatg aagtcgttct tgtagaaagt
     6121 ggaattggta aggtcatgtc tgctatgagt gtggcgattt tggctgatca tttccaggtg
     6181 gatgccctta ttaatacggg ttcagctggg gcagtagcag aaggtatcgc tgttggggat
     6241 gtcgtgattg ctgacaaatt agcctatcat gacgtggatg tcacagcttt tggctatgct
     6301 tatggacaaa tggcgcaaca accgctttat ttcgaatcag acaaaacctt tgttgctcaa
     6361 atccaagaga gtttatctca attggaccaa aactggcatc ttggtttgat tgctacagga
     6421 gatagttttg ttgcaggaaa tgacaagata gaagcgatta agtcccattt cccagaagtt
     6481 ttagccgtgg agatggaggg ggcagctatt gctcaagcag cgcatgccct caatctccca
     6541 gtcttagtca tccgagctat gagtgacaat gccaaccatg aagcaaacat cttttttgat
     6601 gagtttatta tcgaagctgg acgtcgctct gcccaagtct tgttggcctt tttgaaggct
     6661 ttagattaag cggaaatttg acagtttttc tagcttatga taagatttaa gtaaagaaaa
     6721 gctagaaaac gtttcagagg atattatgag tattgaaatg accgtcagtg agattgcaga
     6781 ggtcttagga ttatctcgcc aagcaatcaa taaccgtgtc aaagaattac cagaagaaga
     6841 cacagataaa aatgacaaag gggtaacagt tgttaccaga agtggcttga ttaagctaga
     6901 agaaatctat aaaaaaacga tttttgaaga tgagcctgtc agtgaagatg tcaaacaacg
     6961 tgaactgatg gagattctag tggatgagaa gaatgcagaa attcttcgtc tttatgaaca
     7021 attaaaagcc aaggatcgtc agttatcaga aaaagacgag cagatgcgta tcaaagaccg
     7081 tcagattgct gagaaagaca aacaattaga tcagcaacaa caattgaccc ttcaagccat
     7141 gaaggatcaa gaaaatctta agctagagct ggaccaagca aaagaagaag tccaatccac
     7201 taaaaaaggc ttttttgctc gtttatttgg aggataatca aggagctgtt taggttaaat
     7261 gctaacctga tggcttcttt tgtttgtgaa tagtatagtt gattagaaca gagacagtag
     7321 aggagaggta cagaatggaa cgattagaag attacattgc ttttgattta gaatttaatc
     7381 agcacgaagg acaaacacac ttgattcaag catcggcagt gcgttttaga gatggtcggg
     7441 aaatcgatgc ctatgattcc tatgttcata ccagcgtccc tctaaaaagc tttatcaatg
     7501 gtttgaccgg gattacagct gagaccttaa aagatgctcc tccagttgag aaagtcttag
     7561 aagaattcca agagtttgtg ggttctttgc tgatgatagg ctacaatgct gctaaaagtg
     7621 atttacctat tttagcagag catggtttag actatagcca acagtacaag gtggatttgt
     7681 atgatgaagc ttttgaacgt cggagttcag atttacatgg tattgccaat ctcaaattgc
     7741 aaactgttgc ctcatttctt ggatttcaag gtcagtctca taatagttta gaggatgctc
     7801 ggatgacggc gcgtgtttac gaatccttct tagagtcgga tcaagctagg gaattgttag
     7861 agacagaaag tagcttatca aacaatcctt ttggtggctt ggacttgtct caattatttg
     7921 actaggagtg cctatgaaac ctgaaaaacc taaaaaattg ggtcttaaac agatttacct
     7981 caatcttgat aaaatcctct ttctattttt cttgattttt atgatagtgg agtatttgtg
     8041 ggtaccattc aattcatggt tggctagctt cttattagat cagacaggtt atctttttat
     8101 ttcctataac aatgtcttag ccatccttac tcattctcca ttgattagtc tagctttttt
     8161 agccttgatt gtaattaacc ttctggttgc ttattttcaa ataggactcc tctttattgg
     8221 tgctcgtcat ctcctctata atgaaaagcg aaggctaatt gagtatatcc gcaaggtttt
     8281 ccatgaaagt tttggattta tgaaaaagct aacttgtgct aaagccttgt ttatcttttt
     8341 ctatatagct atgctttttc cttttatacg gaaaatgctg aagatttatt atcttaataa
     8401 aatcgtcatt ccagagttta tccaagctta tttagaagat aaatattgga tgtggtggct
     8461 gagcatccta cttctatctc ttatctttct ctatgtctct gtcagattga tgtttgccct
     8521 tccgaagatt gtatatgatc agctgactgt tcgagaagca gtgatgttta gcttggagaa
     8581 aaccaagaag agagttactt tttatgcttg gaatttattt tacatcttgc tcaaagcaca
     8641 tttattattt tatcttcctt tgattccttt attattggct caaactttgg tagatgatat
     8701 cactcagaga gagtctctga ttcttggtat tttgaatttt gtcgtgatta aaaatctcta
     8761 ttatatggct ctgacttatt ttttggttaa atttgtttca tttttgacag gaaaggagct
     8821 ggatatgctt cctaggagag aaaaagatca catcgtgcga tggggtgtca tgacttgtgc
     8881 cagtcttttc tttgccttag aaggttatat ttatctggag gctcccatgg ttcatctacc
     8941 tcaacttatt tctcaccgag gggtttccaa tgcaaatggg attcaaaata cagtagagtc
     9001 cttggaaact acagcacaac tcaaaccaga cttggtggag acggacgtgc aggaaacaaa
     9061 agatgggcag tttgtcatga tgcatgatgc taacttgaaa aatctagcag gtatcaataa
     9121 aagtcctcaa gacttaaact tggaggagct taaagggatt gatatttttg aaaatggcta
     9181 ccagactaaa atttcaagct ttgaagatta tctcagtcga gccaacgaac ttggtcaaaa
     9241 attactaatt gaaattaaaa ccagtaaaaa agatagtcca gacatgatga accgcttttt
     9301 agcccgttat gctgcaaagc tcaagattta tggacatcaa atccagtctt tagactacca
     9361 tgttgtcgaa aaagtaagac agtatgatgc cgaactgcca gtttatttca tcatgcccta
     9421 caattctgta tttcctaaaa caagagcgac aggatatact atggagtact caaccttgga
     9481 tgaatatttt gtaagcaaac tatggacaac ggatcagaaa ctttatgtct ggactgtcaa
     9541 tgattcagaa gctatcagca aatctcttca cttaggagta gatggagtga ttacagatga
     9601 tttggaaaaa gttcagcggg aaatagaagt agcccaagaa gatccagaat atacggattt
     9661 gctcttgaaa aaagcattgg aattctttga attttagtaa taaaaaagag gaactgttgt
     9721 tcctcccatg ataggtaagt attcttgtga atgcttgctt ttttgtggtt gcaatccgtt
     9781 tacgagaatt gtttgtattg ttcttgtttc aatttacttt atagtgcttt gaagttggaa
     9841 tgctacacta taacttctaa aatatagtaa aatgaaccaa aaatagtaca caatgtggta
     9901 taatcttctt atggcatatt caatagattt tcgtaaaaaa gttctctctt attgtgagcg
     9961 aacaggtagt ataacagaag cgtcacacgt tttccaaatc tcacgtaata ccatttatgg
    10021 ctggttaaag ctaaaagaga aaacaggaga gctaaaccac caagtaaaag gaacaaaacc
    10081 aagaaaagtt gatagagata gacttaaaaa ctatcttact ga
//
LOCUS       DAVLHC010000065         9986 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.066, whole genome shotgun sequence.
ACCESSION   DAVLHC010000065 DAVLHC010000000
VERSION     DAVLHC010000065.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 9986)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9986)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9986
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.066"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(29..838)
                     /locus_tag="VXE25_001884"
     CDS             complement(29..838)
                     /locus_tag="VXE25_001884"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HEV0772294.1"
                     /translation="MSEIGFKYSILASGSSGNSFYLETSKKKLLVDAGLSGKKITSLL
                     AEINRKPEDLDAILITHEHSDHIHGVGVLARKYGMDLYANEKTWQAMENSKYLGKVDS
                     SQKHIFEMGKTKTFGDIDIESFGVSHDAVAPQFYRFMKDDKSFVLLTDTGYVSDRMAG
                     IVENADGYLIEANHDVEILRSGSYAWRLKQRILSDLGHLSNEDGAEAMIRTLGNRTKK
                     IYLGHLSKENNIKELAHMTMVNQLAQADLGVGVDFKVYDTSPDTATPLTEI"
     gene            complement(840..2189)
                     /gene="vicK"
                     /locus_tag="VXE25_001885"
     CDS             complement(840..2189)
                     /gene="vicK"
                     /locus_tag="VXE25_001885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall metabolism sensor histidine kinase
                     VicK"
                     /protein_id="HEV0772295.1"
                     /translation="MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQI
                     NQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSEVIRLTQENLEQESKRLNSILFY
                     MTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE
                     LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSH
                     ELRTPLTSVKSYLEALDEGALCETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATS
                     LLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIWMEIDTDKMTQVVDN
                     ILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSR
                     AQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED"
     gene            complement(2182..2886)
                     /locus_tag="VXE25_001886"
     CDS             complement(2182..2886)
                     /locus_tag="VXE25_001886"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000722069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEV0772296.1"
                     /translation="MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAE
                     QPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKDSEFDKVIGLELGADDYVTKP
                     FSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
                     HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPE
                     YILTRRGVGYYMRNNA"
     gene            complement(2942..4117)
                     /gene="mutY"
                     /locus_tag="VXE25_001887"
     CDS             complement(2942..4117)
                     /gene="mutY"
                     /locus_tag="VXE25_001887"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="A/G-specific adenine glycosylase"
                     /protein_id="HEV0772297.1"
                     /translation="MLDLKEYGIVMWPEEKVISFREKLLAWYDENKRDLPWRRSKNPY
                     HIWVSEIMLQQTRVDTVIPYYERFLDWFPTVESLATASEESLLKAWEGLGYYSRVRNM
                     QAAAQQIMTDFGGQFPNTYEGISSLKGIGPYTAGAISSIAFNLPEPAVDGNVMRVLAR
                     LFEVNHDIGIPSNRKIFQAMMEILINPDRPGDFNQALMDLGSDIESPVNPRPEESPVK
                     DFSAAYQNGTMDRYPIKSPKKKPVPIYLKALVVKNSQGQFLLEKNESEKLLAGFWHFP
                     FIEVDNFSQEEQFDLFHQVAEESVNFGPSPEESFQQDYDLDVDWLDVCFDTVQHVFSH
                     RKWHVQIVAGQVSDFHDFSDREVRWLSPEEFKNYPLAKPQQKIWQAYAQANLDSSQD"
     gene            complement(4445..6115)
                     /locus_tag="VXE25_001888"
     CDS             complement(4445..6115)
                     /locus_tag="VXE25_001888"
                     /EC_number="6.3.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate--tetrahydrofolate ligase"
                     /protein_id="HEV0772298.1"
                     /translation="MKTDIEIAQSIELKPIVDVVEKLGISYDDLELYGKYKAKLSFDK
                     IRAVESNPVGKLILVTAINPTPAGEGKSTLTIGLADALNKIGKKTMIAIREPSLGPVM
                     GIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLHQGNELGIDQRR
                     ILWKRVVDLNDRALRHVTVGLGGPLNGIPREDGFDITVASEIMAILCLATDIEDLKRR
                     LANIVIGYRYDRTPVSVGDLQVEGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIA
                     HGCNSVLATTTALHLADYTVTEAGFGADLGAEKFLDIKTPNLPTSPDAVVIVATLRAL
                     KMNGGVAKDALTEENVEAVRAGFANLKRHVENIRKFGIPAVVAINEFVSDTEAEIAAL
                     KELCALIDVPVELASVWADGVEGGVELAETVVKTIAENPANYKRLYDNDLSVQEKIEK
                     IVTEIYRGSKVNFEKKAQTQIAQVVQNGWDKLPICMAKTQYSFSDNPNALGAPENFEI
                     TIRELVPKLGAGFIVALTGDVMTMPGLPKRPAALNMDVESDGTVLGLF"
     gene            6345..7034
                     /gene="coaB"
                     /locus_tag="VXE25_001889"
     CDS             6345..7034
                     /gene="coaB"
                     /locus_tag="VXE25_001889"
                     /EC_number="6.3.2.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000699493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopantothenate--cysteine ligase"
                     /protein_id="HEV0772299.1"
                     /translation="MKILVTSGGTSEAIDSVRSITNHSTGHLGKIITETLLSAGHEVC
                     LITTKRALKPEPHPNLSIREITNTKDLLIEMQERVQDYQVLIHSMAVSDYTPVYMTGL
                     EEVQASSNLKEFLSKQNHQAKISSTDEVQVLFLKKTPKIISLVKEWNPTIHLIGFKLL
                     VDVTEDHLVDIARKSLIKNQADLIIANDLTQISADQHRAIFVEKNQLQTVQTKEEIAE
                     LLLEKIQAYHS"
     gene            7046..7597
                     /gene="coaC"
                     /locus_tag="VXE25_001890"
     CDS             7046..7597
                     /gene="coaC"
                     /locus_tag="VXE25_001890"
                     /EC_number="4.1.1.36"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001284124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopantothenoylcysteine decarboxylase"
                     /protein_id="HEV0772300.1"
                     /translation="MANILLAVTGSIASYKSADLVSSLKKQGHQVTVLMTQAATEFIQ
                     PLTLQVLSQNPVHLDVMKEPYPDQVNHIELGKKADLFIVVPATANTIAKLAHGFADNM
                     VTSTALALPSHIPKLIAPAMNTKMYDHPVTQNNLKTLETYGYQLIAPKESLLACGDHG
                     RGALADLTIILERIKETIDEKTL"
     gene            7581..8144
                     /locus_tag="VXE25_001891"
     CDS             7581..8144
                     /locus_tag="VXE25_001891"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000747407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HEV0772301.1"
                     /translation="MKKRSNIAPIAIFFATMLVIHFLSSLIFNLFPFPIKPTIVHIPV
                     IIASIIYGPRVGVTLGFLMGLLSLTVNTITILPTSYLFSPFVPNGNIYSAIIAIVPRI
                     LIGLTPYLVYKLMKNKTGLILAGALGSLTNTIFVLGGIFFLFGNVYNGNIQLLLATVI
                     STNSIAELVISAILTLAIVPRLQTLKK"
     gene            8426..8953
                     /locus_tag="VXE25_001892"
     CDS             8426..8953
                     /locus_tag="VXE25_001892"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HEV0772302.1"
                     /translation="MNTRKKTQFMTMTALLTAIAILIPIVMPFKIVIPPASYTLGSHI
                     AIFIAMFLSPLMAVFVILASSFGFLMAGYPMVIVFRAFSHISFGALGALYLQKFPDTL
                     DKPKSSWVFNFVLAVVHALAEVLACVLFYATSGTNVENMFYVLFVLVGFGTIIHSMVD
                     YTLALAVYKVLRKRR"
     gene            8965..9480
                     /locus_tag="VXE25_001893"
     CDS             8965..9480
                     /locus_tag="VXE25_001893"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription repressor NadR"
                     /protein_id="HEV0772303.1"
                     /translation="MTKDRKQALLQLLKEAPKALNGQSLAEHFHVTRQVIVQDIAILR
                     ADGAPILSTNRGYIYKQIDTNPYVHKLFKVKHEVEEIGQELLAIVDNGGHVQNTLIDH
                     PVYGEIETLLKLSCRRDVQHFLEQVEHSDFRPLSELTDGIHYHLVEAETQQDLHYIEE
                     ALDQLGYLVKD"
     gene            complement(9477..9944)
                     /locus_tag="VXE25_001894"
     CDS             complement(9477..9944)
                     /locus_tag="VXE25_001894"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000085289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="8-oxo-dGTP diphosphatase"
                     /protein_id="HEV0772304.1"
                     /translation="MSRSQLTILTNICLIEDLETQRVVMQYRAPENNRWSGYAFPGGH
                     VENGESFAESVIREIYEETGLTIQNPQLVGIKNWPLDTGGRYIVICYKATEFTGTLQS
                     SEEGEVSWVQKDQIPNLDLAYDMLPLMEMMEAPDKSEFFYPRRTEDDWEKKIF"
BASE COUNT         2937 a         2250 c         1802 g         2997 t
ORIGIN      
        1 taaaaagaac accttctcag cgttctttct atatctctgt caatggtgtt gcggtatctg
       61 gtgaggtatc ataaacctta aagtctactc cgactcccag atcagcttga gccagctgat
      121 tgaccatggt catatgagcc agttccttga tattgttttc cttagataaa tgcccaaggt
      181 aaatcttctt agtacgattt cctagcgtcc gaatcatagc ttcagcaccg tcctcgttag
      241 aaaggtgacc aaggtcagat aggattcgtt gtttgagtcg ccaagcgtaa gaacctgatc
      301 gcaaaatctc tacatcatgg ttggcctcga taagatagcc atccgcattt tcgacaatgc
      361 ccgccatacg gtcactgaca taacctgtat ctgtcaaaag gacaaaactc ttgtcatcct
      421 tcataaagcg atagaactgc ggtgcgactg catcatggct tacaccaaaa ctctcgatgt
      481 cgatatctcc aaaagttttg gttttaccca tttcaaaaat atgcttttgc gaagaatcca
      541 ccttgccaag atatttacta ttttccatag cttgccaggt cttttcattg gcataaagat
      601 ccataccata cttgcgagcc aaaacgccta ctccatggat atgatctgaa tgctcatggg
      661 taatcaagat ggcatccagg tcttctggct tgcggttaat ttcagctagc agactggtaa
      721 ttttcttgcc agacaagcct gcatccacta aaagcttctt ttttgaggtt tccagataaa
      781 aagaatttcc actggaaccc gacgctaaaa tactgtattt aaagcctatt tcactcattc
      841 tagtcttcta cttcatcctc ccatacttct tctttcactg catccttatc ataagggagc
      901 acaatggtaa aggttgaacc cttgccgtat tcactcttgg cccaaataaa gcccttatgt
      961 tgtttgataa tttctttagc gatagacagt cctagacctg taccaccttg tgcacgactt
     1021 ctagcacgat ccacacgata gaaacggtca aagatacgtg gtaaatcctg cttaggaatc
     1081 cccaaaccgt ggtcagaaat ggataaaatc atctggtctt cagttgtctt cattctgaca
     1141 gtgattttac ccccatctgg cgaatactta atagcattat ttaaaatatt gtcgacaacc
     1201 tgcgtcatct tatctgtatc aatttccatc cagatagaat tgatgggata atctctcacc
     1261 aactcatatt ttttctcctt ttcctgtcct ttcatcttgt caaaacgatt gaggataaag
     1321 gtaataaaag cagtgaagtt aatcagttcc acatctagga gactggtagc attatcaata
     1381 cgtgaaagat ggaggagatc cgtcaccatg cgcatcatac ggttggtctc atcaagagaa
     1441 accttgataa agtctggtgc tacagtttca cacaaagccc cctcatccaa ggcttcaaga
     1501 taggatttta cgctagtcag aggagtccgt aactcatggc taacattgga aacaaagagt
     1561 cttcgttctc gttcttcctt ctcctgctcc gtcgtatcat gcaaaacagc caccaaacct
     1621 gaaataaagc cagactctcg acgtatcaag gcaaagcgaa ctcgaaggtt caaatattcg
     1681 ccattgatat cttgggaatc tagcaacaat tctggacttt gggtaatcaa atcacgcaat
     1741 tcatagtttt cttctatctt gagcaattcc aaaatgcttc tattcagaac atcttcctta
     1801 accaacccca gttgcttctt ggctgtatca ttaatcatga taatctgacc ccgacggttg
     1861 gtcgcaagaa ccccatctgt catataaaac agaatactat ttagcctctt actctcttgt
     1921 tctagatttt cctgagtgag acgaataacc tccgacaagt cattcaaatt attggtaata
     1981 ttggtgattt cagacccacc ttgcatatca agaaccttgg aataatctcc tgcaatcaaa
     2041 tctttaacct tttgattgat ttgcttcaac tgaatattat cacgtctatt ttccagtaat
     2101 aagagggtca caacaaggat gaaacctaac aaaatcagga taaagataaa atctctggta
     2161 aaaatggttt gtttcagtaa atcaagcatt atttctcatg taatacccta caccacggcg
     2221 cgtcaagata tactctggtc ggctgggcgt atcttcaatc ttctcacgca gacgtcgtac
     2281 agtcacatca actgtacgga catcaccaaa atagtcataa ccccagacag tctcaagcaa
     2341 gtgttcgcgc gtgatgactt gacctgtatg cgatgctaaa tgatacaaaa gctcaaattc
     2401 acgatgggtt aagtctagtt cttcgccata ttttttagcc acgtaggcgt ctggaacaat
     2461 ttctaaatcc ccaatttgga taggttgagg tttactatct gcttcctgac catctactgg
     2521 cataggttga gaacgacgca gaagagcttt aacacgcgcc tgcaactcac gattggagaa
     2581 gggtttcgtt acatagtcat ctgccccaag ttccaaaccg ataaccttat caaattcact
     2641 atctttggct gaaagcataa gaatgggcac actgcttgtc ttacgaatgg tcttagcaac
     2701 ttctaaacca tcaatttctg gaagcatcaa atccagaata ataatatctg gttgctctgc
     2761 ttcaaattgc tctagcgctt cacgaccatt aaaagcagtt acaacttcgt aaccttcctt
     2821 ggtcatatta aacttgataa tatccgagat tggtttctca tcatctacaa ttagtatttt
     2881 tttcatatgt tcaccttttt ctccactatt ataccaaaaa aatagtcaga agacacaata
     2941 gctagtcttg gctactgtct aagttggctt gtgcataagc ctgccagatt ttttgttggg
     3001 gtttggcaag tgggtaattc ttgaattctt ctggtgaaag ccagcgaact tccctatctg
     3061 aaaaatcatg gaagtcactc acctgacctg ctacaatctg cacatgccat tttcgatgac
     3121 taaaaacatg ctggactgta tcaaaacaaa catcaagcca atcaacatct aggtcatagt
     3181 cctgctggaa actctcttct ggactgggac caaagttcac actttcttcc gcaacctgat
     3241 gaaagaggtc aaactgctct tcttgcgaaa agttatcaac ttctataaag gggaaatgcc
     3301 aaaaacctgc caagagcttt tcgctttcat ttttttcaag taaaaattgt ccttgagaat
     3361 ttttcacaac taaggcttta agataaatag gaaccggctt tttcttagga gatttaattg
     3421 gataacggtc catggttcca ttctgatatg ccgcactaaa gtccttgact gggctttctt
     3481 caggtctggg atttacagga gactcaatat cagaccctaa gtccatcaag gcttgattaa
     3541 aatcacctgg acgatccgga ttaatcaaga tctccatcat tgcctgaaaa atttttcgat
     3601 tacttggaat cccaatatcg tggttgactt caaacagacg cgccaagacc cgcatgacat
     3661 taccatctac agctggctca ggcaagttaa aagcaatact ggaaatggct cctgctgtgt
     3721 aaggtccaat ccctttcaag ctggaaattc cttcataggt atttggaaat tggccaccaa
     3781 agtcagtcat aatctgctgg gctgcagcct gcatattgcg aactcgagaa taatagccca
     3841 agccctccca agctttcagt aaactctcct cagacgcagt tgccagactt tcgacagttg
     3901 gaaaccagtc caggaatctt tcgtagtaag ggataactgt atccaccctg gtctgctgaa
     3961 gcatgatttc agatacccag atgtgataag gatttttact tctcctccaa ggcaaatctc
     4021 ttttgttttc atcataccaa gcgagaagtt tctcacggaa agaaatgact ttctcctccg
     4081 gccacatgac gataccgtat tctttcaaat ctaacatatc tctagtataa cacagaaggt
     4141 ttcacctgtc tttgtatctg atttataata ttttcaatag atagtatata acttttctat
     4201 ctacttatac tcaatgaaaa tcaaagagca aactaggaag ctagccgcag gttgctcaaa
     4261 acactgtttt gaggttgtgg atagaactga cagagtcagt atcatatacc tacggcaagg
     4321 tgaagctgac gtagtttgaa gagattttcg aagagtataa atcttattga tgaactgctt
     4381 gcagtctgag aaaaaatgag cttggatatt atttccaaac tcacttaaag tcaatttcaa
     4441 tccactagaa caagcctagt acagttccat cgctttcaac atccatgttg agagctgctg
     4501 gacgttttgg aagacctggc atggtcataa catcaccagt taaggcaacg atgaagcctg
     4561 cacctaattt tggtaccaat tcacgaatgg taatttcaaa gttttctggt gctccaagcg
     4621 catttggatt gtctgagaaa ctgtattgag ttttagccat acagattggc aatttgtccc
     4681 aaccgttttg aacgacttga gcaatttgtg tttgagcttt cttctcaaag ttcactttgc
     4741 taccacgata gatttcagtg acaatttttt caatcttttc ttggacagaa aggtcattat
     4801 catacaaacg tttatagtta gctggatttt cagcaattgt cttaacaact gtttcggcaa
     4861 gttctactcc accttctact ccatcagccc agacactagc caattcaact ggtacatcga
     4921 ttaaggcaca gagttctttt aaggctgcaa tttcagcttc tgtatcagat acaaattcgt
     4981 taatagctac aactgctgga ataccgaact tacggatatt ttcaacgtgg cgtttcaagt
     5041 tagcaaaacc tgcacgaact gcctctacat tttcttcagt cagagcatct ttagccacac
     5101 caccattcat cttaagggca cgaagggttg cgacaataac aactgcatct ggagatgttg
     5161 gcaagtttgg tgtcttgata tcaaggaatt tctcagcacc aaggtccgca ccaaaaccag
     5221 cttcagtaac agtgtaatca gccaagtgaa gggctgttgt cgtcgccaaa acagagttac
     5281 agccatgagc gatattggca aatggaccac cgtgtacaaa ggcaggtgta ccgtaaattg
     5341 tctgaaccaa gtttggctta atagcatcct tcaaaatcaa agccaaggca ccctcaacct
     5401 gcaaatcacc tacagaaaca ggcgtacggt catagcgata accaataacg atattcgcca
     5461 aacgacgttt caagtcctcg atgtccgttg ccaagcaaag aattgccatg atttctgaag
     5521 caactgtaat atcaaaacca tcctcacgtg gaataccgtt tagaggacca ccaagaccaa
     5581 cagtcacatg gcggagcgca cggtcgttca agtccacaac gcgtttccag aggatacgac
     5641 gttgatcaat tcccagctca ttcccttggt gcaagtggtt gtcaatcaag gcagaaaggg
     5701 cattgttggc agttgtaata gcatgcatat ctccagtaaa gtggaggttg atgtcttcca
     5761 ttggcagaac ttgtgcatac ccaccaccag cagcaccacc cttgatcccc atgactggac
     5821 caagagacgg ttcgcggata gcaatcatgg ttttcttgcc aatcttgttc aaggcatccg
     5881 caagaccaat ggtaagcgta gactttcctt cacctgcagg tgttgggttg atggcagtaa
     5941 ccaagatcaa tttaccgact ggattgctct caactgcccg aattttatca aagctgagtt
     6001 tagccttgta ctttccgtac aactccaaat cgtcgtaaga aataccaagt ttctctacaa
     6061 catcaacaat tggcttcaac tcaatactct gtgcgatttc aatatctgtt ttcattcaaa
     6121 attcctctaa cctcttatat gataattcat tatatcacaa aacaagattt ttaacatcct
     6181 aaaactctct aaacgttcgt aaatatctct gtttttaagg cttttagagt cctttcttaa
     6241 attttatatg gctttatagt ttgaaactat aataaatctt cgtttttacc aaaaatttat
     6301 cactttcatt ttacttaccg cttatttttg tgtacaatag tgctatgaaa attttagtta
     6361 catcgggcgg taccagtgaa gctatcgata gcgtccgctc tatcactaac cattctacag
     6421 gtcacttggg gaaaattatc acagagactt tgctttctgc agggcatgaa gtttgtttaa
     6481 ttacgacaaa acgagctctg aagccagagc ctcatcctaa cctaagtatt cgagaaatta
     6541 ccaataccaa ggaccttcta atagaaatgc aagaacgtgt tcaggattat caggtcttga
     6601 tccactcaat ggctgtttct gactacactc ctgtttatat gacagggctt gaggaagttc
     6661 aggctagctc caatctaaaa gaatttttaa gcaagcagaa tcatcaggcc aagatttctt
     6721 caactgatga ggttcaggtt ttgttcctta aaaagacacc caaaatcata tccctagtca
     6781 aggaatggaa tcctactatt catctgattg gtttcaaact gctggttgat gttaccgaag
     6841 atcatctggt tgacattgca cgaaaaagtc ttatcaagaa tcaagcagat ttaatcatcg
     6901 cgaatgacct gactcaaatt tcagcagatc agcaccgagc tatatttgtt gagaaaaatc
     6961 agcttcaaac agtccagact aaagaagaaa ttgcagaact cctccttgaa aaaattcaag
     7021 cctatcattc ttagaaagga aaactatggc aaacattctc ttggctgtaa cgggttcaat
     7081 cgcctcttat aagtcggcag atttagtcag ttctctaaaa aaacaaggcc atcaagtcac
     7141 tgtcttaatg actcaggctg ctacagagtt tatccaacct ttgacactac aggtactctc
     7201 acagaatcct gtccacttgg atgtcatgaa ggaaccctat cctgatcagg tcaatcatat
     7261 cgaacttgga aaaaaagcag atttatttat cgtggtacct gcaactgcta acactattgc
     7321 aaaactagct cacggatttg cggacaacat ggtaaccagt acagctctag ccctaccaag
     7381 tcatattccc aaactaatag ctcctgctat gaatacaaaa atgtatgacc atccagtaac
     7441 tcagaataat ctgaaaacat tagaaaccta cggctatcag ctgattgctc ctaaggaatc
     7501 cctactagct tgtggagacc acggacgagg agctttagct gacctcacaa ttattttaga
     7561 aagaataaag gaaactatcg atgaaaaaac gctctaatat tgcacccatt gctatctttt
     7621 ttgctaccat gctcgtgata cactttctga gctcacttat ctttaacctt tttccatttc
     7681 caatcaaacc gaccattgtt catattcctg tcattattgc cagcattatt tatggtccac
     7741 gagttggggt tacacttgga tttttgatgg gattacttag cttgacggtt aacacgatta
     7801 cgattctacc gacaagctac ctcttctctc ccttcgtacc aaacggaaac atctactcag
     7861 ctatcattgc catcgtccca cgtattttga ttggtttaac tccttactta gtctataaac
     7921 tgatgaaaaa caagactggt ctgattttag ctggagccct tggttccttg acaaatacta
     7981 tctttgtcct tggaggaatc ttcttcctat ttggaaatgt ttataatgga aatatccaac
     8041 ttcttctggc aaccgttatc tcaacaaatt caattgctga attggtcatt tctgcaattc
     8101 taaccctagc cattgttcca cgactacaaa ccttgaaaaa ataaaaacaa tctccgcttt
     8161 caaacctgaa ggtggagatt ttgctctata cagtttcttt ttaatgaaat ctttactata
     8221 gtaaaacgaa ataagaacag gataaatcga tcaggacagc caaatcgatt tctaacaatg
     8281 ttttagaagt agaggtggac tattctagtt tcaatctact ataactttta actaaaaaat
     8341 tatctataaa cccaagtaaa ttcttgcttt attgtctggt ttattgtacc atactagtgt
     8401 atatgcagtt aaaaaggaga ttcttgtgaa tacacggaaa aagacacaat ttatgacaat
     8461 gacagccctt ttaacggcta ttgcgatttt gattccaatt gttatgcctt tcaagattgt
     8521 cattccacct gcttcctata ctttggggag ccacatcgct atttttatag ccatgttctt
     8581 gtcgcccttg atggcagttt ttgtcatcct agcctctagt tttggatttt tgatggctgg
     8641 ctatcccatg gttatcgttt ttcgggcttt ttcccatata tcttttggtg ctttaggagc
     8701 tctttaccta caaaaattcc ccgataccct agataaacca aaatcttcct gggttttcaa
     8761 ctttgttttg gctgttgttc atgcccttgc tgaagtatta gcctgtgtcc ttttttacgc
     8821 aacttcgggt accaatgtag aaaacatgtt ctatgttcta tttgtgctag ttggatttgg
     8881 cacaattatc catagtatgg tagactatac attagcacta gctgtctata aagtgcttcg
     8941 aaaacgccgt taaaaggaaa agctatgaca aaagatcgca aacaagccct gctccaactc
     9001 ttgaaagaag ctcctaaagc ccttaatggc caaagtttgg cggaacattt tcatgtcaca
     9061 cgtcaggtca ttgtgcagga cattgcaatt ttgagagccg atggcgctcc tatcctatcc
     9121 accaatcgtg gctacatcta taagcaaatt gataccaatc cttatgttca caaacttttc
     9181 aaagtgaaac atgaagttga agaaatcggt caggaactcc ttgctattgt cgataatggt
     9241 gggcatgtcc agaatacctt gattgaccat cccgtttatg gagaaattga aaccttgctt
     9301 aaactgtctt gtcgcagaga tgtgcaacat tttctagaac aagtcgagca ttctgacttt
     9361 agacctctat ctgaattgac agatggcatc cattaccacc tagtcgaagc cgaaacacaa
     9421 caagacctcc actatatcga ggaggccttg gatcagctag gttatttagt aaaagactag
     9481 aagattttct tttcccaatc gtcttctgta cggcgagggt agaaaaattc agacttatca
     9541 ggagcttcca tcatctccat caagggtagc atatcatagg ccagatccaa gtttggaatc
     9601 tggtcttttt gcacccaaga aacttctccc tcttctgaag attgaagagt tccagtaaac
     9661 tcagttgcct tataacaaat gacaatatag cgcccacctg tatccagtgg ccaattttta
     9721 atgccgacaa gttgaggatt ttggatagtc aaccctgttt cttcatagat ttcacgaatg
     9781 acagactctg cgaaagactc gccattttct acatggcctc ctggaaaggc ataaccagac
     9841 cagcgattgt tttcaggagc gcgatactgc atcaccacgc gctgagtttc gaggtcttca
     9901 atcagacaaa tgtttgttaa aatcgttaat tgtgaacggg acataaattt actcgctttc
     9961 taatttatta aattttcaga cttggt
//
LOCUS       DAVLHC010000066         9755 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.067, whole genome shotgun sequence.
ACCESSION   DAVLHC010000066 DAVLHC010000000
VERSION     DAVLHC010000066.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 9755)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9755)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9755
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.067"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            70..1329
                     /locus_tag="VXE25_001895"
     CDS             70..1329
                     /locus_tag="VXE25_001895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TRZ/ATZ family protein"
                     /protein_id="HEV0772305.1"
                     /translation="MKVFQHVNIVTCDQNFHVYLDGILAVKDSQIVYVGQDKPAFLEQ
                     AEQIIDYQGAWIMPGLVNCHTHSAMTGLRGIRDDSNLHEWLNDYIWPAESEFTPDMTT
                     NAVKEALTEMLQSGTTTFNDMYNPNGVDIQQIYQVVKTSKMRCYFSPTLFSSETETTA
                     ETISRTRSIIDEILKYKNPNFKVMVAPHSPYSCSRDLLEASLEMAKELNIPLHVHVAE
                     TKEESGIILKRYGKRPLAFLEELGYLDHPSVFAHGVELNEREIERLASSQVAIAHNPI
                     SNLKLASGIAPIIQLQKAGVAVGIATDSVASNNNLDMFEEGRTAALLQKMKSGDASQF
                     PIETALKVLTIEGAKVLGMENQIGSLEVGKQADFLVIQPQGKIHLQPQENMLSHLVYA
                     VKSSDVDDVYIAGEQVVKQGQVLTVEL"
     misc_feature    1405..1540
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00557"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="ribosomal protein L10 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00557"
     gene            1579..2079
                     /locus_tag="VXE25_001896"
     CDS             1579..2079
                     /locus_tag="VXE25_001896"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001287276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L10"
                     /protein_id="HEV0772306.1"
                     /translation="MSEAIIAKKAELVDVVAEKMKAAASIVVVDARGLTVEQDTVLRR
                     ELRGSEVEYKVIKNSILRRAAEKAGLEDLASVFVGPSAVAFSNEDVIAPAKILNDFSK
                     NAEALEIKGGAIEGAVASKEEILALATLPNREGLLSMLLSVLQAPVRNVALAVKAVAE
                     SKEDAA"
     gene            2155..2523
                     /gene="rplL"
                     /locus_tag="VXE25_001897"
     CDS             2155..2523
                     /gene="rplL"
                     /locus_tag="VXE25_001897"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L7/L12"
                     /protein_id="HEV0772307.1"
                     /translation="MALNIENIIAEIKEASILELNDLVKAIEEEFGVTAAAPVAVAAA
                     DAADAGAAKDSFDVELTSAGDKKVGVIKVVREITGLGLKEAKELVDGAPALVKEGVAT
                     AEAEEIKAKLEEAGASVTLK"
     gene            2710..2883
                     /locus_tag="VXE25_001898"
     CDS             2710..2883
                     /locus_tag="VXE25_001898"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001168336.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772308.1"
                     /translation="MQKEGQSSRQFVKSHLMTIMGVDIVKATQLVDEMEQVGLIRFDE
                     FGNVGILVLEGQS"
     gene            2880..3128
                     /locus_tag="VXE25_001899"
                     /pseudo
     CDS             2880..3128
                     /locus_tag="VXE25_001899"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017648301.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
     gene            3142..3465
                     /locus_tag="VXE25_001900"
     CDS             3142..3465
                     /locus_tag="VXE25_001900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772309.1"
                     /translation="MTFLDDYHKKHNYPLFYESYLQNIMEFLESQDIKNGADAFVDDH
                     QNLVFVLYGQGYRAEGKEGILTTQVTVKAYDEDKQPINFANLLDSLIVSEYQMEPNLW
                     EVSHD"
     gene            3458..3838
                     /locus_tag="VXE25_001901"
     CDS             3458..3838
                     /locus_tag="VXE25_001901"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arsenate reductase family protein"
                     /protein_id="HEV0772310.1"
                     /translation="MIDLYLSKNSQRNQLLLDFFQNYGIEVSCHSVSEMTKDKLIEMM
                     SYSSDCFEFLSPNLLRFKNRDNLRLTDFIEMILKNPELTIRLPLAVSNKRVYPNLNLE
                     EARALLPRDTKQLIYMAQTHYLSN"
     gene            3851..4045
                     /locus_tag="VXE25_001902"
     CDS             3851..4045
                     /locus_tag="VXE25_001902"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000840775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HEV0772311.1"
                     /translation="MAERFWENLSIILAERNISWIELTRKMFAGEFHYPSELNRLYQK
                     IRHYKMEQRMPQSPWVERIV"
     gene            4087..4674
                     /locus_tag="VXE25_001903"
     CDS             4087..4674
                     /locus_tag="VXE25_001903"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000821297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEV0772312.1"
                     /translation="MKRIIPVYIFQQVNVLLVSLYLLKFLCIGELTILQILYCASLIS
                     FLWMYAQRKQAHKVNMKSRIKWIGIGLASLLIISLCFSLIHAQESTNQANLIGLQYQV
                     PWFSFLLFLINASMVEEFLYREILWNLVRKLDIRVALTSVLFALAHHPGTIIAWCLYV
                     SLGMFLGLVRYKLDLWGSMGLHLVWNLLVYSLLLF"
     gene            4876..5013
                     /locus_tag="VXE25_001904"
     CDS             4876..5013
                     /locus_tag="VXE25_001904"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004264816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SapB/AmfS family lantipeptide"
                     /protein_id="HEV0772313.1"
                     /translation="MAEEVLNLQLVSVQVDETDEVDGMRFSTFSTNRCGNWSAFSWEN
                     C"
     gene            5192..7801
                     /locus_tag="VXE25_001905"
     CDS             5192..7801
                     /locus_tag="VXE25_001905"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000386153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lanthionine synthetase"
                     /protein_id="HEV0772314.1"
                     /translation="MDYNFNLEHPFFFTNNDYSTDTSIKYQVSLPFNWHEVMNNDEWV
                     YQYPIGKFVERQGWKIHISSEYNSSHELLQDVAKICHEMRIPFKHLSTEDKFIMRNGK
                     LVSRGFSGKFITCYPNQNELESVLQRLESALKQYNGPYILSDKRWDEAPIYLRYGVFR
                     PSRDDEKKVAIDELIVGDEVVKDERLPVFKIPKGIVPPDFLNKWLDKKDKKQGDFPFI
                     IDNAIRFSNSGGIYNARLKEDGKKIILKEARPYTGLGFDGTYSSERLASECKALKILN
                     EWSETPKIYWHGKIWEHTFLGIEHMKGVPLNRWVTNNFPLYEVVDKTKDYLLRVSKIV
                     EKLIDLTNKFHSENVYHQDLHLGNILVKDEDEISIIDWEQAVFSNDEKVVHKVAAPGF
                     RAWRETLPSEIDWYGIRQIAHYLYMPLVTTSDLTYNYVSQTRIEGKKLFESLGYTREH
                     IDYVESLLSYLDSKCPQIENISRKKVLKPMHEIRTIESEQDIQDFIIKLLRGFTLTYG
                     QWRKEFQSRFFPVHYYGLNFNQGIAFSDLAILWSYQQLAKKVKNFKFDDYYEIRTQVI
                     NEAVNNFKKSSLSGLFDGKIGTIWLIYEFGEIDRAVELFTTHFIEIFENSQNKNLYSG
                     QAGILLVGLYFLSKGGIDNKLGEEILIRLREYTLNYIENPETFCKVGASDVQSNDPYE
                     NFGGLLYGHAGVAWLFGEAYKLTGESIYKNGLELAVDKELVAYKVDSNNSLQYSQGHR
                     LLPYLATGSAGLLLLINRNKEILSSKYLKYLTSLERATDVVFCVLPGLFNGFCGLEVA
                     NNIYSDIDDNFSGQKKLIEQLYRYLCVIEEGFVIAGDNGLKITTDIASGFAGVAIGLV
                     SIMDNKLTILPQI"
     gene            7834..>9755
                     /locus_tag="VXE25_001906"
     CDS             7834..>9755
                     /locus_tag="VXE25_001906"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004263477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S9 family peptidase"
                     /protein_id="HEV0772315.1"
                     /translation="MNQSNEIFLNTIQEKTHYKRSISSSFQELKKWNSLIFRRGRYWY
                     QFDNWSIPNTGVIKEWYVEDNDWIPKVSSSSLDNSNSLKIVFDVEKYTLPDDSILQDV
                     RISSDESYIVLVVSSLRSTNLIGIKKYTMEELFIIEDISVESSFYLGKFGVMYTRSKE
                     YGRPSKLFYKSFDSFTEEELFEENECSFRLKIVHIDSNNCFVKSVDFQKGRIFLYSFD
                     RTGFVRHSYTETVAPTPRDIALFSTEKAQYFLGLSSTEEKKDQLILRETSSGDRVSIT
                     IPYQDRARRVHCIGRYILLDCSNAANSVFYLATFKNNSLRELSVNKITFDEKTTLYEN
                     SFSDRVLLFLERRTFYEKILSFDLIENTLKTEFERPIIKSNNTKYFSKVIWTKKDSYD
                     VSIPISLFWKSEDTDELPRRKKCILSVYGAYGKNDNSDLDEIMLSIIDAGFIYAIVHV
                     RGGGYLGGEWYRSGKALNKWNSIRDFIEGVNYLRENDVIDSKRLGLITSSAGGIIAGA
                     VLNEEKNLLQSILLFSPFINPYDTLQNPNDPLSKTEIAEWGDIRDPEVKAYIKSYSPM
                     QNIEKARDSNTVIVNILGEKDPYINNNEVIEWSKKLNSIGVKSLLYLNKAAGHGGFTP
                     SDVLLMIDTLNYFFEEV"
BASE COUNT         3245 a         1432 c         2019 g         3059 t
ORIGIN      
        1 acctacggca aagtgaatct gaagtggttt gaagagagta caacttgtct tttaaaaaag
       61 gagtctataa tgaaagtctt tcagcatgta aatatcgtga cttgtgatca aaatttccat
      121 gtttatcttg atggaatctt agcagtcaag gattctcaaa tcgtctatgt cggtcaagat
      181 aagccagcgt ttttagaaca agctgagcag attatagact atcagggagc ttggattatg
      241 cctggtttgg tcaattgtca cacccattct gcaatgacag gtctgagagg gatccgagat
      301 gacagcaatc tccatgaatg gctcaatgac tatatctggc cagcagaatc tgagtttact
      361 cccgacatga ctaccaatgc ggtcaaagaa gccctgacag agatgctcca gtcaggaaca
      421 acaaccttta acgatatgta taatcccaat ggtgtggata tccagcaaat ttatcaggtg
      481 gtgaaaactt ccaagatgcg ttgttatttt tctccgactc tcttttcttc agagacagaa
      541 acaactgctg agactataag cagaactcga tccatcatag acgaaatctt aaaatataaa
      601 aatccaaatt tcaaggttat ggtagcacct cattctccgt atagctgcag tagagacttg
      661 ctggaagcga gtttggaaat ggcaaaagag ctaaatattc cgctccatgt ccatgtggcg
      721 gagaccaagg aggagtcagg aattatcctc aaacgatacg gcaaacgccc ccttgctttt
      781 cttgaagaac tgggttattt agatcatccg tccgtatttg ctcacggggt cgaattaaac
      841 gagagagaaa ttgaacgctt ggcatcttct caagtggcta tcgcccacaa tcctatcagt
      901 aacctcaaac tggcatcagg aattgctcca attatccagc tccaaaaagc gggagtagca
      961 gtcggaattg cgactgactc ggttgcttcc aataacaatc tagatatgtt tgaggaagga
     1021 aggactgcag ctcttcttca gaagatgaaa agtggggatg ccagccagtt tccaatcgaa
     1081 acagctctca aggtactgac aatcgaaggg gctaaggtcc ttggaatgga aaatcagata
     1141 ggaagtctgg aagtcggcaa gcaagcagat tttctggtca ttcaaccaca agggaaaatt
     1201 catctccaac ctcaggaaaa tatgctgtct cacctggttt atgcagttaa atctagtgat
     1261 gtagatgatg tttatatcgc cggagaacag gttgttaagc aaggtcaagt cctgacagta
     1321 gaactttaaa agaaaaatca cgaaaaattt taaaaaaagt ttgcaaaaat cttgcattct
     1381 ttttttgact atgctatact tatatacggt ttaaaaaaac tgcctaagac agtaggggag
     1441 ctcgactcat aaatatccta ccgaggacaa gacgtatcat gtaaaaagaa gcgtattgta
     1501 ctttcgtgtc taggtttggg cgcgtttttc tttttgaaaa attccccaag caaaataatt
     1561 acggaggtga acacactaat gagtgaagca attattgcta aaaaagcgga actagttgac
     1621 gtagtagctg aaaaaatgaa agctgctgca tctatcgtcg ttgtagacgc tcgtggtttg
     1681 acagttgagc aagatacagt tcttcgtcgt gagcttcgtg gaagcgaagt tgagtataaa
     1741 gttattaaaa actcaatctt gcgtcgtgca gctgaaaaag ctggtcttga agatcttgca
     1801 tctgtatttg ttggaccatc tgcagtagca ttttctaatg aagatgttat cgcaccagcg
     1861 aaaatcttga acgacttttc taaaaacgct gaagcacttg aaattaaagg tggtgcaatc
     1921 gaaggcgctg tcgcatctaa agaagagatt cttgcacttg caactcttcc aaaccgcgaa
     1981 ggacttcttt ctatgctcct ttctgtactt caagcgccag tgcgcaacgt tgctcttgca
     2041 gtcaaagcgg ttgcagaaag caaagaagac gcggcttaat cttaagctac acagcgtagc
     2101 ctagctacga aaaaaactat tataaaattt aaaacttatt tggaggaaat aacaatggca
     2161 ttgaacattg aaaacattat tgctgaaatt aaagaagctt caatccttga attgaacgac
     2221 cttgtaaaag ctatcgaaga agaatttggt gtaactgcag ctgctcctgt agctgttgct
     2281 gcagctgatg cagctgatgc tggtgctgct aaagattcat tcgacgttga attgacatct
     2341 gcaggcgaca aaaaagttgg cgttatcaaa gttgtacgtg aaatcactgg tcttggtctt
     2401 aaagaagcta aagaacttgt tgacggtgca ccagcacttg ttaaagaagg cgttgcaact
     2461 gcagaagctg aagaaatcaa agctaaattg gaagaagctg gagcttcagt tactcttaaa
     2521 taatagagta tcgcaatttg attgcggaat ccctatttac cagtctttga gagcgataag
     2581 cgattgatag aaactgataa attgatttgc tttcctgcca aaaattcttt ggcaggattt
     2641 ttgttttaat aaactttcgg gggtagacac tagattgtct accccttttt ttgtgtttcg
     2701 gaggtaatta tgcaaaagga aggacagtca tcacgtcaat tcgtgaagag tcatctcatg
     2761 actatcatgg gagttgatat tgtaaaagca actcagttag ttgatgaaat ggaacaagta
     2821 ggtttaatcc gatttgatga atttggaaat gttggaattt tagtcttgga gggacaatca
     2881 tgaagcgtat taccgctagt caatatcaga catcagagcg ttattataag ctccccaaac
     2941 ttttatttga gagtgaacgg tataagaata tgaaactgga ggttaaggtg gtttactcag
     3001 ttttaaaaga tcggttggag ttgtctttga gcaaaggttg gattgatgag gatggggcta
     3061 tttatttgat ttattccaat tcaaatttga tggcactttt aggctgttca aagtcaaaat
     3121 tactctccat gtgagtttga agtgacattt ttagatgatt accataaaaa acataactac
     3181 ccactatttt acgaatccta tcttcaaaac attatggaat tccttgaaag tcaggatata
     3241 aagaacggag ctgatgcctt tgtagatgat catcaaaatc ttgtttttgt tttatatgga
     3301 caaggctatc gagccgaggg aaaagaggga atacttacaa cccaagtaac tgtaaaagct
     3361 tatgatgaag acaagcaacc gattaacttc gcaaatttat tagattcctt aatcgtctca
     3421 gagtatcaaa tggaaccgaa tctttgggag gtctcccatg attgatctct atctaagtaa
     3481 aaatagccaa agaaatcaac ttcttttaga cttcttccaa aactatggca tcgaggtatc
     3541 ttgtcattca gtttctgaaa tgacaaagga taaattaatt gagatgatga gctattcttc
     3601 agattgtttt gagtttttat ctcccaattt attacgattt aagaaccgtg acaatttaag
     3661 attaacggat ttcattgaaa tgatattaaa aaatcctgaa ctaaccatca gacttcctct
     3721 tgcagtttca aataagagag tttatccaaa tctaaatttg gaggaagcta gagctttatt
     3781 gccaagagat acgaaacaat tgatttacat ggcgcaaaca cattatttat ctaactaaag
     3841 gagaagcaat atggctgaac gattttggga gaacttgtcc attattttgg ctgaaagaaa
     3901 tatcagctgg attgagctaa ccagaaaaat gtttgcggga gagtttcact atccaagtga
     3961 attgaatcgt ttgtatcaaa agattcgtca ctacaagatg gaacaacgaa tgcctcaaag
     4021 tccatgggta gaaaggattg tgtaggtatt agatttagat tatgaagatt tatttcggag
     4081 gtaactatga aaagaataat tccagtttat atattccaac aagtaaatgt cctattggta
     4141 tctctatact tactgaaatt tctttgtatc ggtgagttaa ctatactaca gattctatat
     4201 tgtgcgtcac tcatttcttt tttatggatg tatgcccaac gtaaacaagc gcataaggtc
     4261 aatatgaaat caaggataaa atggattggt attggattag ccagtctact gattataagt
     4321 ctatgtttta gtctaatcca tgcgcaagaa agcacgaatc aagcaaactt aattgggctt
     4381 caatatcaag ttccttggtt ttcattttta ttgttcttaa tcaatgcgag tatggttgaa
     4441 gaatttctgt atagagaaat tttatggaac ttggttagaa aattagatat tcgagttgct
     4501 ttgacaagtg ttttatttgc cttagcacat catccaggaa ccattatagc ttggtgtttg
     4561 tatgtatcgc tggggatgtt tttagggctt gtacgctaca aattggactt atggggcagt
     4621 atggggttac atttggtgtg gaacctacta gtttatagtt tgctgctttt ttaaaatagg
     4681 taacctgatt tttaggtaac ttctaaaact aacttccagt tttgggagag agatggaagt
     4741 tactttgaaa agttacggaa acattatttt ctatgtgaca acattgtata attgcttgca
     4801 ttttactggt ggagagagta taatgagggt ggataaagta cttaatccca aaaatttaaa
     4861 taggaggagc tagctatggc agaagaagta ttaaatcttc aattagtatc tgttcaagtt
     4921 gacgaaacag atgaagttga tggaatgcga tttagtacat tcagtacaaa tcgttgcggt
     4981 aactggagtg cttttagttg ggaaaattgt taattcattt aaattgtaaa ctttagagat
     5041 tctctggagt tatggatgtc gttccaatat gtgcacgttg gaatgttagt gcttatatgg
     5101 ggagaatcca aaggattctc cctttttatt taaataagtc tgtctagcta tagatatatt
     5161 aagtttgata aaatttcttg gagattttgt tatggattat aatttcaatt tggagcatcc
     5221 tttctttttc actaataatg attatagtac agatactagc ataaagtacc aagtaagtct
     5281 gccttttaat tggcacgaag taatgaataa tgatgagtgg gtttatcaat accctattgg
     5341 aaaatttgtt gaaagacaag ggtggaaaat acacattagt tcagagtata acagttcaca
     5401 tgaattgtta caagatgtag caaaaatttg ccatgaaatg cgaattccat ttaaacatct
     5461 tagtacagaa gacaaattta tcatgcgaaa cgggaaattg gttagtcgag gattttctgg
     5521 taaatttatt acatgttatc caaatcaaaa tgaattagag tcggttttgc aaaggttaga
     5581 aagtgcttta aagcaatata atgggccata tattttaagc gataaacgtt gggatgaagc
     5641 accaatatat ctgaggtatg gtgtgtttag gccgtcaagg gatgatgaaa agaaggttgc
     5701 tattgatgaa ttaattgttg gcgatgaagt tgttaaagat gaacgtttac cagtatttaa
     5761 aattccaaaa ggtatagtgc cccctgactt tttgaataaa tggcttgaca agaaagataa
     5821 aaaacaggga gactttccct ttattataga taatgcaatt agattttcaa acagtggtgg
     5881 gatatataat gctaggctaa aagaagatgg gaaaaaaata attttaaaag aggctagacc
     5941 gtatacaggt ctaggatttg atggtactta ttcttcagag agattagctt cggagtgcaa
     6001 agcactaaaa attctaaatg aatggagtga gacgcctaaa atatactggc acggtaagat
     6061 ctgggagcac accttcttag gaattgaaca tatgaagggc gttccactaa atagatgggt
     6121 taccaataat tttcctttat atgaagttgt tgataagacc aaagattatc tattgagagt
     6181 ttcaaagata gtagaaaaac tcatcgattt aacgaataag tttcattctg aaaatgtata
     6241 tcatcaagat ttacatttag gaaatatctt ggttaaggat gaagatgaga ttagtataat
     6301 agactgggaa caggctgtct tttcaaatga tgaaaaagtt gtacataaag ttgcagcccc
     6361 tggttttaga gcatggcgag aaacacttcc cagtgagata gattggtatg gtattagaca
     6421 aatagctcat tatttataca tgccactagt aactacatcg gatttgacat acaactatgt
     6481 aagtcaaacc aggatagaag gaaaaaaact atttgagtct ttgggttata caagagaaca
     6541 tatagattat gtagaaagtt tattgtcata tctagattct aaatgtccac agattgagaa
     6601 tatttccagg aaaaaagttt taaaacccat gcatgagatt agaactatcg agagtgagca
     6661 agatatacaa gattttatta taaaattatt gagagggttt acgctaactt atggacagtg
     6721 gcgtaaagaa tttcaatcaa gattcttccc agttcattat tatggtctga attttaatca
     6781 aggaattgcg ttttcagatt tagctatcct ttggagttat caacaactag ctaagaaagt
     6841 aaaaaatttc aagtttgatg actattatga gattcgaaca caggttatta atgaggcagt
     6901 aaataatttt aagaaatcgt ccctttctgg tctttttgat ggtaaaattg gtacaatctg
     6961 gctcatttat gaatttgggg agatagatcg ggcagttgaa ctttttacaa ctcattttat
     7021 agagatattt gagaattcac aaaataaaaa tttatatagt gggcaggctg gaattttact
     7081 ggttggactg tattttctta gtaaaggggg aattgataat aaactaggag aagaaatact
     7141 aattaggctt agagaatata ctttaaatta tatagaaaat ccagaaactt tttgtaaagt
     7201 tggcgctagt gatgttcaga gtaacgatcc ttatgagaat tttggtggat tactatatgg
     7261 tcacgcaggg gtagcttggc tcttcggtga agcttataaa ttaactggtg aaagtatcta
     7321 taaaaatggt ctagaattgg ctgtagataa agaattagtt gcttataaag tagatagtaa
     7381 taattcattg cagtacagcc aaggtcatag attactacca tatctagcaa ctggaagtgc
     7441 tggcctgctt ttacttatta atagaaataa agaaatcttg tcaagcaaat acttaaaata
     7501 tttaacttct ttagagaggg caactgatgt agttttttgt gtattaccag gtttatttaa
     7561 cggattttgt ggtcttgaag ttgctaataa tatatatagt gatatcgatg ataacttttc
     7621 aggacaaaag aaattaattg aacaacttta tagatatttg tgtgtaattg aagaaggatt
     7681 tgttattgcg ggagataatg gtttaaagat aacaacagat attgcttcgg gatttgcggg
     7741 tgttgcaatt ggattggtat caataatgga taataaattg acgattcttc ctcaaatata
     7801 atatttagat accattatta aggggtcata cttgtgaatc agagtaatga aatattttta
     7861 aatacaatac aggaaaaaac acactataag aggtctatct cttcatcatt tcaggaatta
     7921 aaaaaatgga attctttgat atttaggaga gggcgatatt ggtaccaatt tgataattgg
     7981 agtataccca atactggtgt aataaaggaa tggtatgtcg aagataatga ctggattcct
     8041 aaggttagtt cttccagttt agacaattca aattcactta aaattgtctt tgatgtggaa
     8101 aaatatactt tgccagatga tagtatctta caggatgtta ggatttcatc tgatgagagt
     8161 tatatagttt tggttgtatc ctcactgcgt agcactaatt taattggaat aaaaaaatat
     8221 actatggaag agttatttat cattgaagat atttcagtag aaagttcgtt ctatttgggt
     8281 aaattcggtg ttatgtatac tcgctccaaa gagtacggga ggccaagtaa gttattctat
     8341 aaatcttttg atagctttac agaagaggaa ctgtttgaag aaaacgaatg ctcttttcga
     8401 ttaaaaatag tccacattga tagcaataat tgttttgtaa agtcagtaga ctttcagaaa
     8461 ggcaggattt ttctatacag tttcgaccgg acgggttttg ttagacactc ttacacagaa
     8521 acggtagccc caacacctag agatatcgct ctatttagta cagaaaaagc acagtacttt
     8581 cttgggctct cttcaactga agaaaagaaa gatcaactaa ttctaaggga aacttcttcg
     8641 ggagacagag tttctattac tataccatat caagataggg ctagaagagt tcactgtata
     8701 ggacgttata tccttttaga ctgttcaaac gcagcgaatt ccgtctttta tcttgctaca
     8761 tttaaaaata atagtttgag ggagttgagt gttaataaga taacatttga tgaaaagaca
     8821 acactttatg aaaattcatt ttctgatcgt gttcttctgt ttttagagag gagaactttt
     8881 tacgaaaaaa tacttagttt tgatttaata gaaaatacat taaaaactga atttgaaaga
     8941 cccatcataa aatcgaataa tactaaatat ttttctaagg tgatttggac taaaaaagac
     9001 agttatgatg taagcatacc gatttcttta ttttggaaaa gtgaagatac ggatgagctc
     9061 ccaagaagaa aaaaatgtat tctaagtgtc tatggggctt atggtaagaa tgataattct
     9121 gatttagatg aaattatgtt atctataata gatgcaggtt ttatttatgc tatagttcat
     9181 gtaagaggtg gaggctattt gggtggtgaa tggtatcgct caggaaaggc gttaaacaaa
     9241 tggaattcta tcagagattt tattgaggga gtaaattatt taagggaaaa tgatgtaatt
     9301 gacagtaagc gattaggttt aataacttct agtgcaggtg gaataattgc tggtgcggtg
     9361 ttgaacgagg aaaaaaattt attgcaaagc attctcttat tttcgccatt tataaatcct
     9421 tatgatacac ttcagaatcc aaatgatcct ctttctaaga ccgaaatagc agagtgggga
     9481 gatattagag accctgaagt aaaggcttat ataaagtcat attcgcctat gcaaaatatt
     9541 gaaaaggcac gagactcaaa tactgttata gttaatattt tgggtgagaa agacccatat
     9601 attaataata acgaagtgat agagtggtca aagaaattaa attctattgg agttaaaagt
     9661 ttgttgtatt taaacaaagc agctggtcat ggaggtttta ctccatcaga tgttctctta
     9721 atgattgata ctttaaatta tttctttgaa gaagt
//
LOCUS       DAVLHC010000067         9748 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.068, whole genome shotgun sequence.
ACCESSION   DAVLHC010000067 DAVLHC010000000
VERSION     DAVLHC010000067.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 9748)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9748)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9748
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.068"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            33..641
                     /locus_tag="VXE25_001907"
     CDS             33..641
                     /locus_tag="VXE25_001907"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000064115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HEV0772316.1"
                     /translation="MSNEKNTNTNVEKKDATVVAHEIKGELTYEDKVIQKIIGLSLEN
                     VSGLLGIDGGFFSNLKEKIVNSDDVTSGVNVEVGKTQVAVDLNVIVEYQKNVPALYSE
                     IREIVSSEVAKMTDLEIVEINVNVVDIKTKEQHEADSVSLQDRVSDVAESTGEFTSEQ
                     FEKAKSGLGSGFSTVQEKVSEGVEAVKGAANGVVSHENTRVN"
     gene            672..875
                     /locus_tag="VXE25_001908"
     CDS             672..875
                     /locus_tag="VXE25_001908"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CsbD family protein"
                     /protein_id="HEV0772317.1"
                     /translation="MSVEEKLNQAKGSIKEGVGKAIGDEKMEKEGAAEKVVSKVKEVA
                     EDAKDAVEGAVEGVKNMLSGDDK"
     gene            complement(986..1258)
                     /locus_tag="VXE25_001909"
                     /pseudo
     CDS             complement(986..1258)
                     /locus_tag="VXE25_001909"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012514870.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            1567..1854
                     /locus_tag="VXE25_001910"
     CDS             1567..1854
                     /locus_tag="VXE25_001910"
                     /inference="COORDINATES: protein motif:HMM:NF033563.0"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
                     /protein_id="HEV0772318.1"
                     /translation="MIVSLKTKSRKAKDMAESIQGWLAQFLVNLFKSITFDCGKEFSK
                     WKDISNHHDSESFFANLGCPRQRCLNEHSNRLLRCHDLPKQTDFNEVSQEF"
     gene            complement(2132..2902)
                     /locus_tag="VXE25_001911"
     CDS             complement(2132..2902)
                     /locus_tag="VXE25_001911"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000229327.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="HEV0772319.1"
                     /translation="MVEIIYFLIIIIASGLGSISGMGGGIIIKPLMDSFGYHSVSDIA
                     FYSSFSVFIMAIISTIKRFSQSKEIKWRLIFTVSFSSVLGGFLGHLIFQVLLSQLSVR
                     LVSIVQMILLFVMLLVSFVLTDFKKTYQFDKIGFYMICGLLLGLISSFLGIGGGPLNV
                     SLLMVFFSISIKEATMYSLAIIFFSQLSHLATIVVVTGLNQYHLAPVPVIFLASICGG
                     VLGTVVSKVLPENWVRYCFKGMLFFVMGMTLYNLFHIL"
     gene            complement(2917..3765)
                     /locus_tag="VXE25_001912"
     CDS             complement(2917..3765)
                     /locus_tag="VXE25_001912"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000782422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formylglycine-generating enzyme family protein"
                     /protein_id="HEV0772320.1"
                     /translation="MKMKKIKGGTFMMGTNSEEGFLDDFEGPQVAVSVKDFSIADTPV
                     TNQEFAQFVKETGYKTLAERQEWSFVFILFVPEAEREGYPHPAGTPWWLQVPNACWKH
                     PYGENSNLVGLEDHPVVHVALEDALAFCNWSGMSLPTEAQWEYAARGGRQSEYPWGDT
                     LLEGGYYHANTWQGRFPYENTALDGFIGTAPVYEFLPNDFGLYQMIGNVWEWCRNPRY
                     TLLASFNEDDYELPKYGIQDEEYAIRGGSFLCHCSYCNRYRVAARNGCISTSTSSHLG
                     FRCLKE"
     gene            complement(3762..5237)
                     /locus_tag="VXE25_001913"
     CDS             complement(3762..5237)
                     /locus_tag="VXE25_001913"
                     /EC_number="3.1.6.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398463.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arylsulfatase"
                     /protein_id="HEV0772321.1"
                     /translation="MVQTKQPNIILIVVDQMRADVLSLNSKDKLVSTPTLDMMASVGY
                     NFENAYSPVPSCVPARAALLTGLDQDKSGRVGYQDEVPWNFTNTLPKVFKDMGYQTEC
                     IGKMHVFPSRQRLGFDHVLLHDGYLHVDRKYDKAYGSQFDYASDYLAFLKGKVGYDVD
                     LIDDGMDCNSWEARPWDKDEKLHPTNWVVSESISFLQRRDPTVPFFLKMSFEKPHAPL
                     NPPKYYFDMYMERLPQFLDLHIGNWEVLEKQIPSIYALRGKLKEDDQRRMVAAYFGLI
                     THIDHQISRFLTALKEFRHDKDTIIWFVSDHGDQLGEHYLFRKGYPYQGSIHIPSFIY
                     DPAGLIAGNRGTIKQLVKIQDIFPSLVDLAGGTTTDELDGRSVKNLLFGQYEGWRTEF
                     HGEHALGKDSSQYILTDQWKFIWFPVLNHYQLFDMKKDPHEMNDLYPSEKYQPIVRQM
                     KKKLVDFLRYREEGFVVDEELVPVELSKITPTLTKTGDSQS"
     gene            complement(5560..6915)
                     /locus_tag="VXE25_001914"
     CDS             complement(5560..6915)
                     /locus_tag="VXE25_001914"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001095003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HEV0772322.1"
                     /translation="MNTMLDKMQEKLSPIAMKVGNQKFLVALRDSFVGTMPVIMTGSI
                     ALLLNAFLVDLPQQFHLESITKTFQWLVDINNLVFKGSIPIVSLLFIYCLGVNIAKIY
                     KVDTVSAGLVSLASFVISIGSTVTKSFPLANVGDVKLDQILQGIDNLAFDGKNLMVTI
                     GNVIPGNHINARGYFTAMMIGFLASIIFCKVMKKNWVIKLPDSVPPAIAKPFTSIIPG
                     FMAMYIVAILTYVFHLLSNDLLIDWVYKVLQTPLLGLSQSFFAVILMIFLNKLFWFFG
                     LHGGNVLAPIMEGLFGVAMLANLDAFQKGEPIPYIWTSGSFGAFVWFGGLGLVLAILI
                     FSRNSHYRKVAKLGLAPVLFNIGEPVNYGLPVVLNPLLFIPFVLSPVFMATVAYWATS
                     WGLVSPVTQNVTWVMPPILYGFFSTAFDWRAIILSVVCLIISVLTYFPFVKMADKTEL
                     S"
     gene            complement(6925..7242)
                     /locus_tag="VXE25_001915"
     CDS             complement(6925..7242)
                     /locus_tag="VXE25_001915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000344536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HEV0772323.1"
                     /translation="MNESNLESAMGLIMYGGEAKSNAMEAIQAAKKGDFSKANRRLAD
                     ANAALLQAHKAQTEMLTKEAQGEETSISLLMVHAQDHLMTSLTFVDLAKEVVEVYERF
                     EKN"
     gene            complement(7259..7576)
                     /locus_tag="VXE25_001916"
     CDS             complement(7259..7576)
                     /locus_tag="VXE25_001916"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001151647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEV0772324.1"
                     /translation="MAKVTIMLACAAGMSTSLLVTKMQKAAEDKGLDAEIFAVPAPEA
                     EEIVATKEVNVLLLGPQVRYLLGDFQEKLKDRQIPVAVIPMTDYGMMNGSKVLDLAES
                     LLD"
     gene            complement(7591..8487)
                     /locus_tag="VXE25_001917"
     CDS             complement(7591..8487)
                     /locus_tag="VXE25_001917"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="haloacid dehalogenase-like hydrolase"
                     /protein_id="HEV0772325.1"
                     /translation="MKRLISANPSEILQMNAEELKQSILASEGRVVLSENVVTRETFV
                     GDITNSEIARAFGADMILLNCVDVFEPKIYALDSSGDDVIHRLHQLVACPIGVNLEPI
                     DPSAKMLEETQEIVAGRVASVETLKRIEELGFDFVCLTGNPGTGVSNREIIKAVQTAK
                     ENFSGLIIAGKMHGAGVNEPVAELSVAEQLLEAGADVILVPAVGTVPAFHDQELREVV
                     DLVHSKGGLVLSAIGTSQETSDTDTIKEIALRNKICGVDIQHIGDAGYGGLATVDNIY
                     ALSKAIRGVRHTVSRLARSVNR"
     gene            complement(8484..9707)
                     /locus_tag="VXE25_001918"
     CDS             complement(8484..9707)
                     /locus_tag="VXE25_001918"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013710989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HEV0772326.1"
                     /translation="MGNNKALVSIRDGITLTIPLLLIGSLLMVIASFPIPGWEKYLGD
                     IGVADYLWKGVDSSFGLLGLVASFGIAYFMARQYKVDGIPAGIVSLSSFITVTPFIRG
                     EAGAGMPTAFMASKGLFVAMILGLINGYIYQWFINHNIQIKMPDGVPPAVSKSFSAII
                     PGAVTIVGWLIVYATLDKLSLPNLHEIAQVALGGPLGLLGNNVIGLLILIFLNSSFWF
                     VGLHGGNVVNAVMKPLWLANLDANKVAYQTGETLPNIFTSVFMDNFVFIGGGGATIGL
                     VLALGYLAHKKKASKQLKTLAPITVIPGLFNINEPAMFGVPIVLNILLLVPFILAPMF
                     NLLVAWGAMASGLVPLTYTDPGWTMPPVISGLLATGSISGSLLQIVLIVLDVLLYLPF
                     VIAIEKRFKLLEDCE"
BASE COUNT         3374 a         2032 c         1474 g         2868 t
ORIGIN      
        1 aaaaattact aatttaatta aaggagtttc atatgtcaaa cgaaaaaaac acaaacacta
       61 acgtagaaaa gaaagatgct actgttgtag ctcacgaaat caaaggggaa cttacttacg
      121 aagataaagt tatccaaaaa atcattggtc tttcactaga aaacgtttca ggtcttttgg
      181 gaatcgatgg tggtttcttc tcaaatctta aagaaaaaat cgttaacagc gatgacgtaa
      241 caagtggtgt taacgtagaa gttggtaaaa cacaagttgc agttgactta aacgttattg
      301 ttgagtacca aaaaaatgtt ccagctttat attcagaaat cagagaaatc gtatcttcag
      361 aagttgctaa aatgactgac ttggaaattg ttgaaatcaa cgtaaacgtt gtcgacatca
      421 aaactaaaga acagcatgaa gcagactcag taagccttca agatcgcgta tctgacgttg
      481 ctgaatcaac aggagaattc acttcagaac aattcgaaaa agctaaatct ggtcttggat
      541 ctggtttctc aactgttcaa gaaaaagtta gcgaaggtgt agaagctgtt aaaggtgcag
      601 caaatggtgt agtatctcac gaaaacactc gtgtaaacta agataaaata aatataacag
      661 gagaaattat catgtcagta gaagaaaaat taaatcaagc taaaggttct attaaagaag
      721 gtgttgggaa agccatcggt gatgaaaaaa tggaaaaaga aggagcagct gaaaaagttg
      781 tttctaaagt aaaagaagtt gccgaagacg ctaaagacgc tgtagaaggt gctgtagaag
      841 gtgttaaaaa catgttgagt ggcgacgata aataaggtta aaagttactt tatctttttt
      901 ggtaacatta gtcaaaagag tctgagtcaa gatgattctc agaaaacaaa aagctagaga
      961 ttcccaattg cggaactcta gctttttaat tttgcctctt tctcttatta tatttcagca
     1021 ggttgttggc catgagtatg aatcccatgt caattctcac ttgacgctta cctctcagat
     1081 gacatctctt ataacccaaa caaaccttta tctgcccaaa gacagatttc atatcaatct
     1141 tacgtttagc gaaaatttgt ctacccttgg aagataaaag tgcctgatat tctttagttt
     1201 ttaaacactg gtaacgttca ttcatataca gtcccttttg aggggctgat tcaggttcat
     1261 aatcgcagtc aacattgatt tcaaggctgt ttgctttcta tctccccttt ttcataatgt
     1321 atagtaaaat gaaataataa caggacgaat cgatcgggac agtcaaatcg atttctaaca
     1381 atgttttaga agtagaggtg tactattcta gtttcaatct actatatttt cgtacaggtg
     1441 cttcaatagt ttctatagta aaatgaacca aaaatagtac acgttgcggt ataatgttct
     1501 tgtggcatat tcattagatt ttcgtaaaaa gttctctcct atttgtgagc gaacaggtat
     1561 agtcaattga ttgtcagttt gaagaccaag agtcgtaagg caaaggatat ggcagaatcc
     1621 atccaagggt ggctggcaca atttctagtg aacctcttta aatctattac gtttgactgt
     1681 ggaaaagagt tttcaaaatg gaaagatatt tccaatcatc acgatagtga gagctttttt
     1741 gcgaatctag gatgtccaag acagcggtgt ctcaacgaac attcaaatag acttttaagg
     1801 tgtcatgact tgccaaagca gacagatttc aacgaagtca gtcaagaatt ttaggctggg
     1861 taaaaactca atttcaggag aaaatgaaat aaatattccc acaataaaac gcatagtatc
     1921 aaagtttttc caacacctga tattatacat tttttaattt taaagacttt ttcccagcct
     1981 caagaaatca catcccacct aaatcctttg gataccaaat acctcatcag gtattttctg
     2041 agttggtaag actgtctagc ttaatttgac aaatggaggg cgttaaatcc agtttttaca
     2101 ggaagtctat ttaaatattt tcacactgac cttacaaaat atgaaataaa ttatataaag
     2161 tcattcccat gacaaagaat aacatccctt taaaacagta tcttacccaa ttttcaggta
     2221 agacttttga tacaaccgtc cccaataccc ctccgcatat agaagcaaga aaaataactg
     2281 gaacaggtgc taaatgatac tgatttaaac ctgtaaccac aacaattgta gccaaatgag
     2341 acaactggga aaagaaaata attgcaagag aatacatcgt tgcttctttt atcgaaatag
     2401 aaaaaaacac catcaataaa gatacattga gcggaccacc accaatccct aaaaaactag
     2461 aaatcaagcc caatagaaga ccacaaatca tatagaatcc tatcttatca aattgataag
     2521 tttttttaaa atctgttaaa acaaatgata caagtagcat cacaaatagt aaaatcattt
     2581 gaacaatgga tactagccgt actgataact gagataacaa aacttgaaaa ataagatgac
     2641 ctagaaatcc tcctaaaaca gaagaaaagg ataccgtaaa aatcaatctc cattttatct
     2701 ctttactttg tgaaaatctt ttgattgttg aaataatcgc cattataaaa acagagaaac
     2761 tagaataaaa agcaatatca ctgaccgaat ggtatccaaa actatccata agtggcttaa
     2821 ttataattcc accacccatg cctgatatag aacccaatcc actagctatt ataatgatta
     2881 gaaaataaat aatctcaacc actttttaag tccatcctat tctttcaaac atctaaaacc
     2941 tagatggcta ctagtggaag tagaaataca tccatttcta gcagctactc ggtatcgatt
     3001 acaataagaa caatgacata aaaaggaacc tcctctgata gcatactcct catcttgtat
     3061 cccatatttt ggtaactcat agtcatcttc attaaaacta gctaataagg tatatctcgg
     3121 attgcgacac cattcccaaa cattcccaat catttgatat agaccaaaat cattaggtaa
     3181 aaattcatag acaggagccg ttcctataaa tccatctaag gcagtatttt cataaggaaa
     3241 tcttccttgc caagtattgg catgataata tccaccttct aaaagagtat ctccccaagg
     3301 atattcagat tgtcttcctc ctctagcagc atattcccac tgtgcttcag tcggtaaaga
     3361 cattccgctc caattacaga aagccaatgc atcttctaaa gcaacatgaa ctactggatg
     3421 gtcttctaaa cccactagat tactattctc accgtaggga tgtttccagc aagcgttcgg
     3481 aacttgtaac caccacggag tcccagcagg atgaggatat ccctcccttt ctgcctctgg
     3541 aacgaacaat ataaaaacaa aagaccactc ttgtcgctca gctagtgttt tatagcctgt
     3601 ttctttcaca aattgagcaa attcttgatt cgtaactgga gtatccgcaa tggaaaaatc
     3661 ctttacacta acagcgactt gaggaccttc aaaatcatct aaaaagccct cttcagaatt
     3721 tgttcccatc ataaatgtcc cacccttgat ttttttcatt ttcatgattg actatccccc
     3781 gttttcgtta gagttggcgt tattttagaa agttcaacag gaactaactc ttcatccaca
     3841 acaaaacctt cttctctata tctaagaaag tctactaatt ttttcttcat ctgacgaaca
     3901 ataggttggt atttttcact tggatacaaa tcattcattt catgcggatc ttttttcata
     3961 tcaaataact gataatgatt taaaacagga aaccagataa atttccactg gtctgtcaag
     4021 atatattgac tagaatcttt tcctaaagca tgttcaccat gaaattctgt tcgccacccc
     4081 tcgtactgtc caaataataa attcttaaca ctccgtccat ctagttcatc tgtagtagtt
     4141 cctcctgcca aatccacgag tgaaggaaaa atatcttgaa ttttcactaa ttgcttgatt
     4201 gttcccctat taccagctat caatccagcc ggatcgtaaa taaacgaagg aatgtggata
     4261 cttccctgat aaggatatcc ctttctaaac agataatgtt caccaagctg atctccatga
     4321 tccgaaacaa accagataat cgtatcttta tcatgacgaa attcttttag ggcagtcaaa
     4381 aagcgactaa tttgatggtc tatatgagta atcaatccaa aataagcagc aaccattctt
     4441 ctttgatcat cttcctttaa tttccctctt aaagcataaa tagacggaat ttgcttttct
     4501 aatacttccc aattcccgat atgcaaatcg agaaattgag gcaagcgttc catatacata
     4561 tcaaaatagt attttggggg atttaatgga gcatgtggtt tttcaaaaga cattttgaga
     4621 aaaaaaggaa ccgttggatc tcttctttgt aaaaatgaaa tggactcact cacaacccag
     4681 tttgttggat gtaacttctc atctttatcc caaggtctag cttcccaaga attacaatcc
     4741 attccgtcat caatcaaatc aacatcataa ccaactttac cctttaaaaa ggctagatag
     4801 tcactagcat aatcaaattg acttccataa gccttatcat actttctatc aacatgtaga
     4861 tacccatcgt gaagtaagac atgatcaaac ccaagtctct gtctggaagg aaaaacatgc
     4921 atcttaccaa tacactctgt ttgataaccc atatctttaa agacttttgg aagagtatta
     4981 gtaaaattcc aaggcacctc atcttgataa ccaactcgtc cacttttatc ttggtctaag
     5041 ccagtcaata aagctgccct agcaggaaca caagaaggaa ctggagaata ggcattttca
     5101 aaattataac ctacactagc catcatatct aatgttggag tgctaactag cttatcctta
     5161 ctattcaagg ataagacgtc tgctctcatt tgatctacaa caatcaaaat aatatttggc
     5221 tgttttgtct gaaccataaa atctcctttc taatatggca aaagaggcac aagaagatat
     5281 ctacctttac tgcacccctt tctatatcaa tctctctata taaaacaata acattcttgt
     5341 tatgttttat agaaaaatga actaaaatat gactaaatcg attaggaaat tcaaatcatt
     5401 ttctagtact gttttagaag ttacagtgta ctattccaac ttcaataaat tataaacctt
     5461 tgtctaataa caattttagt ggagataaga aatcctacac ctaactcatc ttacacgtaa
     5521 tctatttcta ttttatcaca aaaaacgcaa gtaagaccat taactcaatt cagttttatc
     5581 tgccattttc acaaatggga aataagtcaa gacactaata atcaaacaaa caactgataa
     5641 gatgatggca cgccaatcaa atgctgtaga gaagaaacca tataaaattg gaggcattac
     5701 ccaagtaacg ttttgtgtaa caggtgaaac aagaccccag cttgttgccc agtaagctac
     5761 cgttgccatg aaaaccgggc taagtacaaa tggtataaat agcaaaggat tcaagacaac
     5821 tggtaaacca taattgaccg gctcaccaat attaaacaga actggtgcta gaccaagttt
     5881 agcaactttt cgataatgac tgtttcttga aaaaattaaa atagcaagta ctaatcctaa
     5941 tcctccaaac cagacaaacg ccccaaaaga cccacttgtc catatataag gaatcggttc
     6001 acctttttgg aaagcatcca gattcgctaa catagcaact ccaaacagcc cttccatgat
     6061 gggagccaat acatttcctc catggagacc aaaaaaccag aataacttat tcaaaaagat
     6121 catcagaata actgcaaaga aactttgaga caaacctagt aatggcgttt gtaacacctt
     6181 gtaaacccaa tcaatcaata agtcattgct aagtaaatgg aaaacataag tcaagatggc
     6241 tactatatac atcgccataa atcctggaat gatagaagtg aacggcttag caatcgcagg
     6301 gggaactgaa tctggtaact tgattaccca gttctttttc attactttac agaaaataat
     6361 agaggctaaa aatccaatca tcatggctgt aaagtagcct ctggcattaa tatggtttcc
     6421 tggaatcaca ttcccaatag ttaccatcag atttttacca tcaaatgcta gattatcaat
     6481 tccttgtaag atttgatcta atttcacatc tcctacattt gccaaaggga aactctttgt
     6541 aactgtactt ccaatcgaaa tgacaaacga agcaagcgat accaaaccag cagaaactgt
     6601 atcaacctta taaatcttag cgatattcac tcccaagcaa tagatgaaca ataaggaaac
     6661 aattggtata cttcccttga ataccaaatt attgatgtca acaagccact gaaaggtttt
     6721 cgtaatactt tctaggtgaa attgttgtgg taaatccact agaaaagcat ttaataacaa
     6781 agcaatggaa cctgtcataa taacaggcat agtccccaca aatgaatcac gtaaagcaac
     6841 taaaaacttc tgattcccaa ctttcattgc aattggagaa agtttttctt gcattttatc
     6901 caacattgta ttcatagcaa attcctaatt tttttcaaat cgttcgtata cttctaccac
     6961 ttctttcgcc aagtcaacaa aggtcagact cgtcattaaa tgatcttgcg cgtgtaccat
     7021 caagaggcta attgatgttt cttccccctg tgcctctttt gtcaacattt ctgtttgagc
     7081 cttatgcgcc tgtaataagg cagcattcgc atcagctaat cttcgattgg ctttagagaa
     7141 atcccctttt tttgctgcct gaatagcctc catagcatta cttttggctt ccccaccata
     7201 cataattagc cccattgcag attctaaatt actttcattc atagcattct cctcaatctt
     7261 agtctaataa actttcagct aaatctaaga ctttagaacc attcatcatt ccataatctg
     7321 tcatcggaat aaccgccaca ggaatctgtc tatcttttag tttttcttga aagtccccta
     7381 gtaaatagcg aacttgaggg cctaaaagca acacatttac ttcttttgtt gctacaattt
     7441 cttctgcttc aggagctgga actgcaaaaa tttctgcatc caacccctta tcttctgctg
     7501 ccttttgcat ctttgtcact agcagacttg tactcatacc tgctgcacat gctaacataa
     7561 ttgttacttt agccatagct tactccttta tcacctattt actgacctag ccaagcgaga
     7621 tactgtatgt ctcactcctc taattgcctt gctcaatgca taaatattat cgactgttgc
     7681 cagtccccca tatcctgcgt cacctatatg ttgaatatca actccacaaa ttttatttct
     7741 aagtgcaatt tccttaatag tatctgtatc agatgtttct tggctagtac caatagcact
     7801 caatacaaga ccacccttac tatgaacgag atcaacgact tcacgcaact cttggtcatg
     7861 aaaggctgga acggttccaa ctgctggaac aagtatcaca tccgcacctg cttccaacaa
     7921 ttgctctgcg acagaaagct ctgccacagg ctcattcact cctgccccgt gcatcttacc
     7981 tgcaataatc aaaccagaaa agttttcctt agcagtttga acagccttaa tgatttctcg
     8041 attgctaact cctgttccag gatttccagt caaacagaca aagtcaaaac ctaactcctc
     8101 tattcgcttc aatgtttcaa cactagcaac acgacctgca acaatttcct gtgtttcctc
     8161 tagcatcttt gcagatgggt caatcggttc caaatttaca ccaattggac aagcaacaag
     8221 ctggtgtaag cgatgaataa catcatcacc tgaactatcc aaagcataaa ttttaggctc
     8281 aaaaacatca acacaattca ataaaatcat atcagctcca aaagctctag caatttcaga
     8341 attagttata tccccaacaa atgtctcacg agtaactaca ttttcagata gaacaactct
     8401 accttcactt gctaaaatac tttgttttaa ttcttcagca ttcatctgta atatctcaga
     8461 tggatttgca ctaattaaac gtttcattcg caatcctcca ataacttaaa ccgtttttca
     8521 atagctatta caaatggtaa ataaagtaag acatccaaaa caatcaatac aatttgtaat
     8581 aatgaaccag aaatacttcc tgtagcaagt aaaccactta taacaggtgg catagtccaa
     8641 cctggatctg tataagttag cggaaccaaa cctgatgcca ttgctcccca cgctactagt
     8701 aagttaaaca ttggagctaa gataaatgga actagtaaca aaatgttcaa aacaatagga
     8761 acgccaaaca ttgctggttc atttatatta aataatccag gtataacagt tataggtgcc
     8821 aaagttttta gttgtttact agctttcttc ttatgtgcta aatatcctaa cgcaagaact
     8881 aaacctatgg ttgcaccacc gccacctatg aatacaaaat tatccataaa tacgctagta
     8941 aaaatatttg gaagagtttc tccagtttga taagctactt tatttgcatc tagattagct
     9001 aaccataacg gtttcataac tgcattaaca acatttcctc cgtgtaatcc tacaaaccaa
     9061 aaactactat taaggaaaat taagataaga aggccaataa cattatttcc taaaagtcca
     9121 agtggacctc ccaaagctac ttgagcaatt tcatgaagat taggtaaact taatttatct
     9181 aaagttgcat aaacaatcaa ccaaccaaca atagtcactg caccaggaat aatggcacta
     9241 aagcttttag atactgctgg tggaacacca tccggcattt ttatctgtat attatgattt
     9301 ataaaccatt ggtagatata gccattaatc aatcctaaaa tcatagcaac aaataaacct
     9361 tttgatgcca tgaaagcggt aggcattcct gctccagcct ctcctctaat gaaaggcgta
     9421 actgtaataa aagatgataa tgacacaata ccagcaggaa taccatcaac tttgtattgt
     9481 ctagccataa agtaagcgat accaaaacta gctacaagac caagtaatcc aaaactacta
     9541 tcaacaccct tccataaata gtcagcaaca ccaatatcac ccagatattt ttcccatcct
     9601 ggaataggaa aacttgcaat aaccattagt aatgaaccta tcaacaataa aggtatagtt
     9661 agagtaatac cgtctcgaat agaaaccaac gctttattat tacccaatct agccgctact
     9721 ggaagtaact tttcttgtaa taattttt
//
LOCUS       DAVLHC010000068         9017 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.069, whole genome shotgun sequence.
ACCESSION   DAVLHC010000068 DAVLHC010000000
VERSION     DAVLHC010000068.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 9017)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9017)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9017
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.069"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(368..1216)
                     /gene="dprA"
                     /locus_tag="VXE25_001919"
     CDS             complement(368..1216)
                     /gene="dprA"
                     /locus_tag="VXE25_001919"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004257994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-protecting protein DprA"
                     /protein_id="HEV0772327.1"
                     /translation="MKITNYEIYKLKKSGLTNQQILKVLEYGENVDQELLLGDIADIS
                     GCRNPAVFMERYFQIDDAHLSKEFQKFPSFSILDDCYPWDLSEIYDAPVLLFYKGNLD
                     LLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGLAKGIDTAAHMAALQNGGK
                     TIAVIGTGLDVFYPKANKRLQDYIGNDHLVLSEYGPGEQPLKFHFPARNRIIAGLCRG
                     VIVAEAKMRSGSLITCERAMEEGRDVFAIPGSILDGLSDGCHHLIQEGAKLVTSGQDV
                     LAEFEF"
     gene            complement(1312..2001)
                     /locus_tag="VXE25_001920"
     CDS             complement(1312..2001)
                     /locus_tag="VXE25_001920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NTP transferase domain-containing protein"
                     /protein_id="HEV0772328.1"
                     /translation="MKAIILAAGLGTRLRPMTENTPKALVQVNQKPLIEYQIEFLKEK
                     GINDIIIIVGYLKEQFDYLKEKYGVCLVFNDKYADYNNFYSLYLVKEELANSYVIDAD
                     NYLFKNMFRNDLTRSTYFSVYREDCTNEWFLVYGDDYKVQDIIVDSKAGRILSGVSFW
                     DAPTAEKIVSFIDKAYASGEFVDLYWDNMVKDNIKELDVYVEELEGNSIYEIDSVQDY
                     RKLEEILKNEN"
     gene            complement(2013..2891)
                     /locus_tag="VXE25_001921"
     CDS             complement(2013..2891)
                     /locus_tag="VXE25_001921"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000837620.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DMT family transporter"
                     /protein_id="HEV0772329.1"
                     /translation="MKSKNGVPFGLLSGIFWGLGLTVSAYIFSIFTDLSPFVVAATHD
                     FLSIFILLAFLLVKEGKVRLSIFLNIRNVSVIIGALLAGPIGMQANLYAVKYIGSSLA
                     SSVSAIYPAISVLLAFFFLKHKISKNTVFGIVLIIGGIIAQTYKVEQVNSFYIGILCA
                     LVCAIAWGSESVLSSFAMESELSEIEALLIRQVTSFLSYLVIVLFSHQSFTAVANGQL
                     LGLMIVFAAFDMISYLAYYIAINRLQPAKATGLNVSYVVWTVLFAALFLGTSLDMLTI
                     MTSLVVIAGVYIIIKE"
     gene            complement(2881..3750)
                     /gene="licA"
                     /locus_tag="VXE25_001922"
     CDS             complement(2881..3750)
                     /gene="licA"
                     /locus_tag="VXE25_001922"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000411210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline kinase LicA"
                     /protein_id="HEV0772330.1"
                     /translation="MEKIIKEKISSLLSQEEEVLSVEQLGGMTNQNYLAKTTNKQYIV
                     KFFGKGTEKLINRQDEKYNLELLKDLGLDVKNYLFDIEAGIKVNEYIESAITLDSTSI
                     KTKFDKITPILQTIHTSAKELRGEFAPFEEIKKYESLIEEQIPYANYESVRNAVFSLE
                     KRLADLGVDRKSCHIDLVPENFIESPQGRLYLIDWEYSSMNDPMWDLAALFLESEFTS
                     QEEETFLSHYESDQTPVSHEKIAIYKILQDTIWSLWTVYKEEQGEDFGDYGVNRYQRA
                     IKGLASYGGSDEK"
     gene            complement(3767..4789)
                     /locus_tag="VXE25_001923"
     CDS             complement(3767..4789)
                     /locus_tag="VXE25_001923"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004257983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alcohol dehydrogenase catalytic
                     domain-containing protein"
                     /protein_id="HEV0772331.1"
                     /translation="MINQIYQLTKPKFINVKYQEEAIDQENHILIRPNYMAVCHADQR
                     YYQGKRDPKILNKKLPMAMIHESCGTVISDPTGTYEVGQKVVMIPNQSPMQSDEEFYE
                     NYMTGTHFLSSGFDGFMREFVSLPKDRVVAYDAIEDTVAAITEFVSVGMHAMNRLLTL
                     AHSKRERIAVIGDGSLAFVVANIINYTLPEAEIVVIGRHWEKLELFSFAKECYITDNI
                     PEDLAFDHAFECCGGDGTGPAINDLIRYIRPQGTILMMGVSEYKVNLNTRDALEKGLI
                     LVGSSRSGRIDFENAIQMMEVKKFANRLKNILYLEEPVREIKDIHRVFATDLNTAFKT
                     VFKWEV"
     gene            complement(4794..5501)
                     /locus_tag="VXE25_001924"
     CDS             complement(4794..5501)
                     /locus_tag="VXE25_001924"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-C-methyl-D-erythritol 4-phosphate
                     cytidylyltransferase"
                     /protein_id="HEV0772332.1"
                     /translation="MIYAGILAGGTGTRMGISNLPKQFLELGDRPILIHTIEKFVLEP
                     SIEKIVVGVHGDWVSHAEDLVDKYLPLYKERIIITKGGADRNTSIKNIIEAIDAYRPL
                     TPEDIVVTHDSVRPFITLRMIQDNIQLAQNHDAVDTVVEAVDTIVESTNGQFITDIPN
                     RAHLYQGQTPQTFRCKDFMDLYGSLSDEEKEILTDACKIFVIKGKDVALAKGEYSNLK
                     ITTVTDLKIAKSMIEKD"
     gene            5837..7324
                     /gene="tacF"
                     /locus_tag="VXE25_001925"
     CDS             5837..7324
                     /gene="tacF"
                     /locus_tag="VXE25_001925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000835918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type IV teichoic acid flippase TacF"
                     /protein_id="HEV0772333.1"
                     /translation="MKSIKLNALSYMGIRVLNIIFPILTGTYVARVLDRTDYGYFNSV
                     DTILSFFLPFATYGVYNYGLRAISNVKDNKKDLNRTFSSLFYLCIACTILTTAVYILA
                     YPLFFTDNPIVKKVYLVMGIQLIAQIFSIEWVNEALENYSFLFYKTAFIRILMLVSIF
                     LFVKNEHDIVVYTLVMSLSTLINYLISYFWIKRDIKLVKIHLSDFKPLFLPLTAMLVF
                     ANANMLFTFLDRLFLVKTGIDVNVSYYTIAQRIVTVIAGVVTGAIGVSVPRLSYYLGK
                     GDKEAYVSLVNRGSRIFNFFIIPLSFGLMVLGPNAILLYGSEKYIGGGILTSLFAFRT
                     IILALDTILGSQILFTNGYEKRITVYTVFAGLLNLGLNSLLFFNHIVAPEYYLLTTML
                     SETSLLVFYIIFIHRKQLIHLGHIFSYTVRYSLFSLSFVAIYFLINFVYPVDMVINLP
                     FLINTGLIVLLSAISYISLLVFTKDSIFYEFLNHVLALKNKFKKS"
     gene            7334..8137
                     /locus_tag="VXE25_001926"
     CDS             7334..8137
                     /locus_tag="VXE25_001926"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004259727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphorylcholine transferase LicD"
                     /protein_id="HEV0772334.1"
                     /translation="MKQLTVEDAKQIELEILDYIDTLCKKHNINYIINYGTLIGAVRH
                     EGFIPWDDDIDLSMPREDYQRFINIFQKEKSKYKLLSLETDKNYFNNFIKITDSTTKI
                     IDTRNTKTYESGIFIDIFPIDRFDDPKVIDTCYKLESFKLLSFSKHKNIVYKDSLLKD
                     WIRTAFWLLLRPVSPRYFANKIEKEIQKYSRENGQYMAFIPSKFKEKEVFPSGTFDKT
                     IDLPFENLSLPAPEKFDTILTQFYGDYMTLPPEEKRFYSHEFHAYKLED"
     gene            8139..8948
                     /locus_tag="VXE25_001927"
     CDS             8139..8948
                     /locus_tag="VXE25_001927"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001199643.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphorylcholine transferase LicD"
                     /protein_id="HEV0772335.1"
                     /translation="MQYLEKKEIKEIQLALLDYIDETCKKHDIPYFLSYGTMLGAIRH
                     KGMIPWDDDIDISLYREDYERLLKIIEEENHPRYKVLSYDTSSWYFHNFASILDTSTV
                     IEDHVKYKRHDTSLFIDVFPIDRFTDLSIVDKSYKYVALRQLAYIKKSRAVHGDSKLK
                     DFLRLCSWYALRFVNPRYFYKKIDQLVKNAVTNTPQYEGGVGIGKEGMKEIFPVDTFK
                     ELILTEFEGRMLPVPKKYDQFLTQMYGDYMTPPSKEMQEWYSHSIKAYRKN"
BASE COUNT         2833 a         1816 c         1521 g         2847 t
ORIGIN      
        1 gactttcctg atagagttgt tcacatctta tttcaattca ctatactttc ccttatactc
       61 aatgaaaagc aaagcgcaaa ctaggaagct agccacaggt tgctcaaagc actgctttga
      121 ggttgtagat aagactgacg aagtcagctc aaaatactgt tttgaggttg cagatggaag
      181 ctgacgtggt ttgaagagat tttcgaagag tattatatga gaaaaatcct ctactctact
      241 aatccactta gaaaaaacgc atattatcaa gtgttaaaaa cttgctaata tgcgttttat
      301 tatggaaatg ttgggttcat tttctcttaa aattgatttt ttcttagaat tctagcttag
      361 gtcattttta aaattcaaat tccgcaagaa catcttgccc actggtgacc aattttgctc
      421 cttcttgaat caaatgatgg caaccgtctg atagtccatc taaaatgcta ccaggaatag
      481 caaagacatc gcgtccttct tccattgctc gctcacacgt aatgagacta cctgaacgca
      541 tcttagcctc tgctacaatc acaccacgac aaagtccagc aatgatgcga ttacgggcag
      601 gaaaatgaaa tttcagaggt tgttcgccag gtccatattc acttagaacc agatggtcat
      661 tgccgatgta gtcttgcaag cgtttattgg ctttaggata aaacacatcc agtcctgttc
      721 caatcactgc aatggttttt ccgccattct gaagagctgc catatgagct gctgtgtcaa
      781 tgcccttggc cagaccactg acaataacca gttcattttc caagccttga atgacttttt
      841 caactgactt agctccctgt ttgctacaag cacgactgcc cacgaccgct accttcggga
      901 atttcaggag gtcaagattt cccttgtaaa ataaaagtac aggcgcatca tatatttcac
      961 tcaaatccca aggataacag tcatctaaaa tagagaaaga tggaaatttt tgaaactctt
     1021 tcgacaaatg cgcatcgtct atctgaaaat aacgttccat aaaaacggct ggattacggc
     1081 aacctgatat atctgcaata tcacccaaca aaagctcctg atcaacattt tcaccgtatt
     1141 ctagcacttt caaaatctgt tgattggtca aacctgattt ttttaactta tagatttcat
     1201 agtttgtgat tttcataaat aactccattt ctttttctac tcatctatct attcgtaaaa
     1261 gttcgtaaaa aatcaaaaaa catccgacta ttttgtcaga tgttggaatc tttaattttc
     1321 gtttttaaga atttcttcta atttacgata gtcttggaca ctatcgatct cataaatgct
     1381 attgccttct aattcttcaa catagacatc tagctctttg atattatcct taaccatatt
     1441 gtcccaatag agatcaacaa attcaccact tgcataagcc ttgtcgataa agctgacaat
     1501 cttttctgca gttggagcat cccagaagga tacaccacta aggatgcgac ctgccttgct
     1561 atcaacaata atgtcttgaa ccttgtagtc atctccatag accaagaacc attcgttggt
     1621 acaatcttca cgataaacac taaaataagt cgaacgagtc aaatcattgc ggaacatatt
     1681 tttaaagaga tagttatctg catcaataac atagctgttg gccaattctt cttttacaag
     1741 atagagagag taaaagttat tgtagtcagc gtatttatca ttgaaaacga ggcaaacacc
     1801 gtatttttct tttaaataat cgaattgttc tttaagataa ccaacgatga tgatgatgtc
     1861 attgattcct ttttctttga gaaactcaat ttggtattca atcaaaggtt tttgattaac
     1921 ctgaaccaag gctttagggg tattttcagt cataggacgc aagcgagttc ccaatcccgc
     1981 tgctaagata atggctttca cacgaatctc ctttattctt taataataat ataaactcca
     2041 gcaatgacga caagtgacgt cataatggtc agcatatcta atgatgttcc caagaaaaga
     2101 gctgcgaaca agacagtcca tactacatag ctcacgttca agcctgtagc cttggctggt
     2161 tgcaagcgat tgatagcgat ataataagcc aagtaggaaa tcatatcaaa ggctgcaaaa
     2221 acaatcatga gacctagcaa ttgtccattg gctactgcag taaatgactg atgagagaag
     2281 agcacaatca caagatagga caagaacgaa gttacttgac ggattaagag ggcttcgatt
     2341 tcactcaatt cactttccat ggcaaaagag ctaagaacac tctcacttcc ccatgcaata
     2401 gcacaaacca aagcacaaag aatcccaatg tagaaagaat taacctgttc aaccttatag
     2461 gtctgagcaa taatccctcc aataatcaag acaatcccaa atacagtatt tttcgaaatc
     2521 ttgtgcttca aaaagaagaa agccaataga actgaaatcg cagggtaaat agccgataca
     2581 gatgaagcta aagaacttcc gatatactta actgcataaa gattggcctg cataccgata
     2641 gggcctgcta gcaaggctcc gatgataaca ctgacattgc gaatatttaa gaaaattgag
     2701 aggcgaactt tcccttcttt taccaagaga aaagctagta agataaagat gctcaaaaaa
     2761 tcatgagttg cagccaccac aaagggtgac aaatctgtaa aaatcgaaaa gatataagca
     2821 ctaaccgtta gacccaagcc ccagaaaata cctgagagaa ggccaaaagg aactccgttt
     2881 ttacttttca tctgaacctc cataagaagc caaaccttta atagctcttt ggtaacgatt
     2941 cacaccatag tcaccaaaat cttcaccttg ctcttcctta tagacagtcc atagactcca
     3001 aatagtatct tgtaaaattt tataaatagc aatcttttca tgagaaaccg gtgtttggtc
     3061 actctcatag tgagataaga aagtttcttc ctcttgggaa gtgaattcag actctaaaaa
     3121 gagggcagcc aaatcccaca ttggatcatt cattgatgaa tattcccagt caatcaaata
     3181 aagtcgtcct tgaggtgatt cgataaagtt ttcaggcacc aaatcgatat gacaagattt
     3241 tctgtcaaca cctaagtcag ccagtctttt ctctaaggag aagactgcat ttctaacaga
     3301 ttcatagttg gcataaggaa tttgttcttc aatcaaggat tcgtattttt tgatttcttc
     3361 aaaaggagca aattctcctc ttaattcctt agcagacgta tgaatagttt gtaatattgg
     3421 agtaattttg tcgaacttgg tcttgattga cgttgaatca agcgtaatcg cagattcgat
     3481 atactcattt actttgatac cagcttcaat atcaaaaaga taatttttta catctaagcc
     3541 taaatccttt agtagttcaa gattgtactt ttcatcttgt cgattgataa gcttttctgt
     3601 ccctttacca aagaatttaa caatgtattg cttatttgtt gttttggcca aatagttttg
     3661 attggtcatt ccacccagtt gttcaacact gaggacttcc tcttcttgac taagtaagga
     3721 agaaattttt tctttaatga ttttctccac aattaacctc cagtacttat acttcccact
     3781 taaacactgt tttaaaggct gtgtttaaat cggttgcaaa gacacgatga atatctttaa
     3841 tttctcttac aggttcttct agataaagga tatttttaag acgattggca aatttcttga
     3901 cttccatcat ttggatagca ttttcaaaat caatgcgacc agaacgagat gacccaacca
     3961 aaatcaagcc cttttctaag gcatcgcgag tattgagatt gactttatat tcgctaactc
     4021 ccatcatgag aatcgttccc tgaggacgaa tgtagcgaat caagtcatta atagctggtc
     4081 cagtaccatc accaccacaa cattcaaaag catggtcaaa ggccaaatct tcaggaatat
     4141 tatccgtaat atagcattct ttggcaaatg agaagagttc caacttttcc caatgacgac
     4201 caataaccac aatctctgct tctggcaaag tatagttgat aatattggca accacaaaag
     4261 ctaaacttcc atctccaata acggcgatcc gctcccgctt gctatgagca agagtcaata
     4321 gacgattcat agcgtgcatg cccacactga caaactctgt aatggctgca accgtatctt
     4381 caatagcatc ataagccacc acacgatctt tagggagaga aacaaactct ctcataaagc
     4441 catcaaatcc actagacaag aaatgggtcc ctgtcatgta gttttcatag aattcttcat
     4501 cactctgcat aggagactga ttgggaatca tgacaacttt ttgaccaacc tcgtaggttc
     4561 cggtcgggtc agaaatgacg gttccacatg actcgtgaat cattgccatt ggaagctttt
     4621 tattcaaaat cttgggatca cgttttccct gatagtaacg ctgatccgca tgacagacag
     4681 ccatgtagtt gggacggata aggatatgat tctcttggtc aatagcctct tcctgatatt
     4741 tgacattgat aaacttaggc ttagttagtt gataaatttg attaatcatt ttactagtct
     4801 ttctcaatca tactttttgc aatcttcaaa tctgttacgg ttgtaatctt cagatttgag
     4861 tattcacctt tggccaaagc cacatctttt cctttgatca caaagatttt acatgcatct
     4921 gtcaagattt ccttctcttc atcagaaaga gatccataaa ggtccatgaa gtccttgcaa
     4981 cggaatgttt gaggtgtttg tccttgataa aggtgagcac gatttggaat atctgtaata
     5041 aattgaccat tggtactttc aacgatagta tcaaccgctt ctaccactgt gtccactgcg
     5101 tcatgatttt gggcaagttg gatattgtcc tgaatcatgc gaagtgtaat aaatggacga
     5161 acagaatcgt gggtaacaac gatatcctct ggagtaagcg gacgataagc atcaatggct
     5221 tcaatgatgt tcttaatact tgtattgcgg tcagcaccac cctttgtaat gatgatacgt
     5281 tccttataaa gaggaagata tttatctaca agatcttctg catgagaaac ccagtctcca
     5341 tgaacaccaa ctacaatttt ttcaatactt ggctccaaga caaatttttc aattgtatga
     5401 atcaaaatag gtcgatcacc tagctctaaa aattgttttg gcaagttact gatccccatg
     5461 cgtgtgccag ttccaccggc aagaattcct gcataaatca tctattttct cctttgtctt
     5521 actaaaaaaa cttattctct ctattatacc acaatctagt cctatcataa aagaaatact
     5581 ggtcctcccc ttctagaata ggagaattat gcagttctat tattcaaaga aactagtcca
     5641 tttctagtaa tgactaggaa ttctgtagca attactaata aatggctgcg aaattttaga
     5701 gtccttcaga ataatatact ttccttaaag aaaacttaaa acttaagatt tgaaacttca
     5761 aagtgattac ttgacttact gcccttcatt tcttattagc taactttatg atataatgaa
     5821 aaacgaggta aattgaatga aaagtataaa attaaatgct ctatcttaca tgggaattcg
     5881 tgtcttgaat attatttttc ccatcctaac tggaacctat gtcgcgcgtg tcttggaccg
     5941 aactgactat ggttacttca actcagtcga cactattttg tcatttttct tgccctttgc
     6001 aacttatggt gtctataact acggtttaag ggctatcagt aatgtcaagg ataacaaaaa
     6061 agatcttaac agaacctttt ctagtctttt ttatttgtgc atcgcttgta cgattttgac
     6121 cactgctgtc tatatcctag cctatcctct cttctttact gataatccaa tcgtcaaaaa
     6181 ggtctacctt gttatgggga ttcaactcat tgcccagatt ttttcaatcg aatgggtcaa
     6241 tgaagctctg gaaaattaca gttttctctt ttacaaaact gccttcatcc gtatcctgat
     6301 gctggtctct attttcttat ttgttaaaaa tgaacacgat attgttgtct atacacttgt
     6361 gatgagttta tcgacgctga ttaactacct gattagttat ttttggatta aaagagacat
     6421 caaacttgtt aaaattcacc taagtgattt taaaccactc tttctccctc tgacagccat
     6481 gttagtcttt gccaatgcca atatgctctt cactttttta gatcgcctct tcctcgttaa
     6541 aacagggatt gatgtcaacg ttagttacta taccatagct cagcgaattg tgaccgttat
     6601 agctggggtt gtaacaggtg caattggagt gagtgtgcct cgtctcagtt actatctggg
     6661 gaaaggagac aaagaagcct atgtttctct ggttaataga ggtagtcgaa tctttaactt
     6721 ctttatcatt ccactgagtt ttggactcat ggttttagga ccaaatgcca tcctacttta
     6781 cggtagtgaa aaatatatcg gaggcggcat cttgacctct ctcttcgctt ttcgtacgat
     6841 tatcctggcc ttagatacca ttcttggttc ccaaattctc tttaccaatg gctatgaaaa
     6901 acgtatcaca gtctatacag tctttgctgg gctactcaat ttgggcttga atagtctcct
     6961 ttttttcaac catatcgtgg ctcctgaata ctacttactg acaactatgc tatcagagac
     7021 ttctctactt gttttctata tcattttcat ccatagaaaa caactcatcc acttgggaca
     7081 tatctttagc tatactgttc gatactctct cttttcactt tcctttgtag caatttattt
     7141 cctgattaat ttcgtgtatc ctgtagatat ggtcattaat ttgccatttt tgattaatac
     7201 tggtttgatt gtcttgctat cagctatctc ttatattagt ctacttgtct tcacaaaaga
     7261 tagcattttc tatgaatttt taaaccatgt cctagcctta aaaaataaat ttaaaaaatc
     7321 ataggagttt aaaatgaaac aactaaccgt tgaagatgcc aaacaaattg aattagaaat
     7381 tttggattat attgatactc tctgtaaaaa gcacaatatc aactatatta ttaactacgg
     7441 tactctgatt ggggcggttc gacatgaggg ctttatccct tgggacgacg atattgatct
     7501 gtccatgcct agagaagact accaacgatt tattaacatt tttcaaaagg aaaaaagcaa
     7561 gtataagctc ctatccttag aaactgataa gaactacttt aacaacttta tcaagataac
     7621 cgacagtacg actaaaatta ttgatactcg aaatacaaaa acctatgagt ctggtatctt
     7681 tatcgatatt ttccctatag atcgctttga tgatcctaag gtcattgata cttgttataa
     7741 actggaaagc ttcaaactgc tgtctttcag taaacataaa aatattgtct ataaggatag
     7801 ccttttaaaa gattggatac gaacagcctt ctggttactc cttcgaccgg tttctcctcg
     7861 ttattttgca aataaaatcg agaaagaaat tcaaaaatat agtcgtgaaa atgggcaata
     7921 tatggctttt atcccttcaa aatttaagga aaaggaagtc ttcccaagtg gtacctttga
     7981 taaaacaatc gatttaccct ttgagaattt aagccttcct gcacctgaaa aatttgatac
     8041 tattttgaca caattttatg gagattatat gaccctacca ccagaagaaa aacgcttcta
     8101 cagtcatgaa tttcacgctt ataaattgga ggattaggat gcaatattta gaaaaaaaag
     8161 aaattaaaga aattcaacta gccctgctgg actatattga tgagacttgt aagaaacatg
     8221 atattcctta ttttctcagt tatggaacca tgcttggagc catccgccac aaaggtatga
     8281 ttccttggga tgatgatatt gatatttccc tttatcgtga ggattatgag cgtttactga
     8341 agattattga agaagaaaat caccctcgct acaaggttct ttcctacgat acatcttctt
     8401 ggtacttcca taatttcgca tcgattttgg acacttctac tgttatagaa gaccatgtta
     8461 agtacaagcg tcatgatacc agccttttca tcgatgtctt cccaattgat cgatttacag
     8521 acttgagcat tgtcgacaag agctataagt atgtggctct tcgtcaacta gcttatatca
     8581 aaaaatcacg agcagttcac ggtgatagca aactaaaaga ttttcttaga ttatgtagct
     8641 ggtacgctct ccgatttgtc aatcctcgct acttttacaa gaaaattgat caactagtca
     8701 aaaatgctgt aaccaacact cctcaatatg aaggaggagt tgggatcggt aaggaaggga
     8761 tgaaagaaat cttcccagtt gataccttta aagaactgat tttaactgag tttgagggcc
     8821 gtatgttgcc tgttcccaaa aaatatgacc aatttttaac ccagatgtat ggcgattata
     8881 tgacaccacc atcaaaagaa atgcaagagt ggtatagtca tagcattaaa gcttatcgca
     8941 aaaactgatt gagggggatt atacaaacta ctaagataga ggttattcaa aaacataatt
     9001 ttagtagaaa atgaaat
//
LOCUS       DAVLHC010000069         8606 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.070, whole genome shotgun sequence.
ACCESSION   DAVLHC010000069 DAVLHC010000000
VERSION     DAVLHC010000069.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 8606)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8606)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8606
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.070"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..130
                     /locus_tag="VXE25_001928"
     CDS             <1..130
                     /locus_tag="VXE25_001928"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611513.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HEV0772336.1"
                     /translation="SFQSLKQLEQAIVDYIDYYNNKRIKVKLKGLSPVQYRTKSFG"
     gene            complement(255..458)
                     /locus_tag="VXE25_001929"
     CDS             complement(255..458)
                     /locus_tag="VXE25_001929"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000594204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0772337.1"
                     /translation="MIKPYSPYAFLSKYLGAILLSFFCYYAKEIGCNNLTLSVWNDNE
                     GALRFYQRQGMKPQETTMEMIID"
     gene            complement(451..1533)
                     /locus_tag="VXE25_001930"
     CDS             complement(451..1533)
                     /locus_tag="VXE25_001930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000040939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HEV0772338.1"
                     /translation="MSKLQQILTYLESEKLDVAVVSDPVTINYLTGFYSDPHERQMFL
                     FVLADQEPLLFVPALEVERASSTVSFPVVGYVDSENPWQKIKHALPQLDFKRVAVEFD
                     NLILTKYHGLKTVFETAEFDNLTPRIQRMRLIKSADEVQKMMVAGLYADKAVHVGFDN
                     ISLDKTETDIIAQIDFAMKREGYEMSFDTMVLTGDNAANPHGIPAANKVENDALLLFD
                     LGVLVNGYASDMTRTVAVGKPDQFKKDIYNLTLEAQQAALDFIKPGVTAHEVDRAARE
                     VIEKAGYGEYFNHRLGHGIGMDVHEFPSIMEGNDMVIEEGMCFSVEPGIYIPGKVGVR
                     IEDCGVVTKDGFDLFTSTSKDLLYFD"
     gene            complement(1659..2441)
                     /locus_tag="VXE25_001931"
     CDS             complement(1659..2441)
                     /locus_tag="VXE25_001931"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type 1 glutamine amidotransferase"
                     /protein_id="HEV0772339.1"
                     /translation="MVYTSLSSKDGNYPYQLNIAHLYGNLMNTYGDNGNILMLKYVAE
                     KLGAHVTVDIVSLHDDFDENHYDIAFFGGGQDFEQSIIADDLPAKKESIDNYIQNDGV
                     VLAICGGFQLLGQYYVEASGKRIEGLGVMGHYTLNQTNNRFIGDIKIHNEDFDETYYG
                     FENHQGRTFLSDDQKPLGQVVYGNGNNEEKVGEGVHYKNVFGSYFHGPILSRNANLAY
                     RLVTTALKKKYGQDIQLPAYEDILSQEIAEEYSDVKSKADFS"
     gene            complement(2441..3784)
                     /locus_tag="VXE25_001932"
     CDS             complement(2441..3784)
                     /locus_tag="VXE25_001932"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011836724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mur ligase family protein"
                     /protein_id="HEV0772340.1"
                     /translation="MNLKTTLGLLAGRSSHFILSRLGRGSTLPGKVALQFDKDILQNL
                     AKNYEIVVVTGTNGKTLTTALTVGILKEVYGQVLTNPSGANMITGIATTFLTAKSSKT
                     GKNIAVLEIDEASLSRICDYIQPSLFVITNIFRDQMDRFGEIYTTYNMILDAIRKVPT
                     ATVLLNGDSPLFYKPTIPNPIEYFGFDLEKGPAQLAHYNTEGILCPDCQGILKYEHNT
                     YANLGAYICEGCGCKRPDLDYRLTKLVELTNNRSRFVIDGQEYGIQIGGLYNIYNALA
                     AVAIARFLGADSQLIKQGFDKSRAVFGRQETFHIGDKECTLVLIKNPVGATQAIEMIK
                     LAPYPFSLSVLLNANYADGIDTSWIWDADFEQITDMDIPEINAGGVRHSEIARRLRVT
                     GYPAEKITETSNLEQVLKTIENQDCKHAYILATYTAMLEFRELLASRQIVRKEMN"
     gene            complement(3883..5199)
                     /locus_tag="VXE25_001933"
     CDS             complement(3883..5199)
                     /locus_tag="VXE25_001933"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000958936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-containing oxidoreductase"
                     /protein_id="HEV0772341.1"
                     /translation="MLTYDLIVIGFGKAGKTLAGKLASAGKKVALVERSKAMYGGTCI
                     NIGCIPTKTLLVAAEKDLSFEEVIATKNTITGRLNGKNYATVAGTGVDIFDAEAHFLS
                     NKVIEIQAGDEKKELTAETIVINTGAVSNVLPIPGLATSKNIFDSTGIQSLDKLPEKL
                     GILGGGNIGLEFAGLYNKLGSKVTVLDALDTFLPRAEPSIAALAKQYMEEDGIELLQN
                     IHTTEIKNDGDQVLVVTEDETYRFDALLYATGRKPNVEPLQLENTDIELTERGAIKVD
                     KHCQTNVPGVFAVGDVNGGLQFTYISLDDFRVVYSYLAGDGSYTLEDRLNVPNTMFIT
                     PALSQVGLTESQAADLKLPYAVKEIPVTAMPRGHVNGDLRGAFKAVVNTETKEILGAS
                     IFSEGSQEIINIITVAMDNKIPYTYFTKQIFTHPTLAENLNDLFAI"
     gene            5392..6618
                     /locus_tag="VXE25_001934"
     CDS             5392..6618
                     /locus_tag="VXE25_001934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000841575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="OFA family MFS transporter"
                     /protein_id="HEV0772342.1"
                     /translation="MKSNRYIIAFAGVILHLMLGSTYAWSVYRNPIIEKTGWDQASVA
                     FAFSLAIFCLGLSAAFMGRLVEKFGPKVMGSLSAFLYAGGNILTGFAIDRQELWLLYL
                     AYGILGGLGLGAGYITPVSTIIKWFPDKRGLATGLAIMGFGFASLLTSPIAQHLIAGV
                     GLVETFYILGASYFIIMLLASQFIKRPNEQELAILSSSGKEKTASLTQGMAANQALKS
                     NRFYMLWIIFFINIACGLGLISAASPMAQEMAGLSTSHAAVMVGVLGIFNGFGRLLWA
                     SLSDYIGRPLTFSILLLVNLFFSLSLWLFTDSVLFVVAMSILMTCYGAGFSLIPAYLS
                     DIFGTKELAALHGYILTAWAMAGLAGPILLAETYKMAHSYTQTLFVFLILYSIALALS
                     YYLGRSIKKESQKALT"
     gene            6817..8391
                     /locus_tag="VXE25_001935"
     CDS             6817..8391
                     /locus_tag="VXE25_001935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000671067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HEV0772343.1"
                     /translation="MKFNELNLSADLLAEIEKAGFVEASPIQEQTIPLALEGKDVIGQ
                     AQTGTGKTAAFGLPTLEKIRTEEATIQALVIAPTRELAVQSQEELFRFGRSKGVKVRS
                     VYGGSSIEKQIKALKSGAHIVVGTPGRLLDLIKRKALKLQDIETLILDEADEMLNMGF
                     LEDIEAIISRVPENRQTLLFSATMPDAIKRIGVQFMKAPEHVKIAAKELTTELVDQYY
                     IRVKEQEKFDTMTRLMDVAQPELAIVFGRTKRRVDELTRGLKIRGFRAEGIHGDLDQN
                     KRLRVLRDFKNGNLDVLVATDVAARGLDISGVTHVYNYDIPQDPESYVHRIGRTGRAG
                     KSGQSITFVAPNEMGYLQIIENLTKKRMKGLKPASVEESFQSKKQVALKKIERDFADE
                     TIRANFEKFGKDARKLAAEFTPEELAMYILSLTVQDPDSLPEVEIAREKPLPFKPSGN
                     GFGGKAKGGRGGRRGDDRRERDRRGNGRRDEFKKGSRGNDRFDKEKRYRKDNKKPRNT
                     LSEKQTGFVIRNKGDK"
BASE COUNT         2473 a         1654 c         1906 g         2573 t
ORIGIN      
        1 gtcgtttcag tcgcttaagc aattggaaca agctattgta gactatattg attactacaa
       61 caacaaacga attaaggtaa aactaaaagg acttagtcct gtgcagtaca gaactaaatc
      121 cttcggataa attaattgtc taactgtttg gggtcagtac acaatacctg atagtatgcg
      181 ttttattgtg ggaagatttt cctcattttc tagtgaaatt gaactttttc taacatcttt
      241 tgatagatga cttcttaatc aattatcatt tccattgttg tttcttgggg tttcatccct
      301 tgtctttgat aaaagcggag agcaccctcg ttatcattcc agacacttag ggttagatta
      361 ttgcagccaa tttctttagc ataatagcag aaaaatgaca ataaaatagc ccctagatat
      421 tttgaaagga aagcataggg gctatatggt ttaatcaaaa taaagcaaat ctttgctggt
      481 gcttgtaaag aggtcgaagc catccttggt aacaacaccg cagtcttcaa tacgaacacc
      541 gactttacca gggatataga tacctggttc aacagagaag cacatgcctt cttcgatgac
      601 catgtcgttt ccttccatga tagatgggaa ttcatggaca tccataccga taccatgccc
      661 gagacggtgg ttgaagtact caccataacc agctttttcg atgacctcac gggcagcgcg
      721 gtccacttca tgagcagtca cacctggctt gataaagtca agagcagctt gttgggcttc
      781 aagagtcaag ttgtaaatat ctttcttgaa ttggtctggt ttgccgacag cgactgtacg
      841 agtcatatct gacgcatagc cattgaccag aacacccagg tcaaagagga gaagagcatc
      901 attttcaacc ttattagctg ctggaatgcc gtgtggattc gcagcattat caccagtcaa
      961 gaccatggta tcaaagctca tttcgtaacc ttcacgtttc atggcaaagt caatttgtgc
     1021 gatgatatct gtctcagtct tatcaagaga aatattatca aaaccaacat gaacagcctt
     1081 gtcagcataa agacctgcaa ccatcatttt ttgcacttca tcagctgatt tgatgaggcg
     1141 catgcgttgg atacgaggag tgaggttgtc aaactcagca gtctcaaaaa ctgttttcaa
     1201 accatggtat ttggtcaaga tgagattgtc aaactcaaca gcgacacgtt tgaagtcaag
     1261 ttgtggaaga gcatgtttga ttttttgcca tggattttca gaatcgacat agcccactac
     1321 tgggaaggaa acggtgctac ttgcacgttc tacttcaaga gctgggacaa agaggagagg
     1381 ttcctgatcc gctaggacaa agaggaacat ttggcgttca tggggatcac tgtaaaaacc
     1441 agtgaggtaa ttgattgtga cggggtcaga tacgacagcg acgtctagtt tttctgattc
     1501 aagatatgtt aggatttgtt gtaatttaga catatgctac cttctttcta cccctctatt
     1561 ttggcaaaaa atgagagaaa atgcaaggga gaagggtaaa agaaaagaca aaaaactccg
     1621 acaagataac ggagttcttt gatatcattt tcctttgttt aagaaaagtc agccttgctt
     1681 ttgacgtcac tgtactcttc agcgatttct tggctgagga tatcctcata ggcagggagt
     1741 tggatatcct gaccatattt cttcttgagg gcagtagtaa ctaggcgata agccagattg
     1801 gcattacgag agaggatagg tccgtggaag taggaaccaa agacattctt ataatgaacc
     1861 ccttcaccga ccttttcttc gttgtttcca tttccataga caacctgtcc cagcggtttt
     1921 tggtcatcag agaggaaggt acggccttgg tgattttcaa atccatagta ggtttcatcg
     1981 aaatcttcat tgtgaatctt gatgtcaccg ataaaacggt tattggtctg gttgagcgtg
     2041 tagtgtccca tgacccctag cccttcgata cgttttcctg aagcttcaac ataatattga
     2101 cccaatagtt ggaaaccacc gcagatagcc agaactacac cgtcgttttg gatgtagttg
     2161 tcaatgctct cttttttagc aggtaggtcg tctgcaatga tactttgttc aaagtcttga
     2221 ccaccaccga aaaaggcgat gtcgtagtga ttttcatcaa agtcatcatg gagagaaacg
     2281 atgtcaacgg tcacatgggc tcccagtttt tcagccacat acttgagcat gaggatgttt
     2341 ccattgtccc cgtaggtatt catgagattt ccgtagaggt gggcaatgtt gagctgatag
     2401 gggtaattgc catcttttga ggaaagtgaa gtataaacca ttagttcatc tcctttctaa
     2461 caatctgacg actagccagc agttcacgaa attccagcat ggcagtataa gttgccagaa
     2521 tataggcatg cttgcagtct tgattctcaa tggtcttgag aacttgctcc agattactcg
     2581 tttcagtgat tttctcagct ggatagccag tcactcggag gcgacgagcg atttcagaat
     2641 gacgaacacc gccagcgttg atttcaggaa tgtccatgtc agtgatttgt tcaaagtctg
     2701 catcccagat ccagctagtg tcaattccat ctgcatagtt ggcattaagg aggacagata
     2761 ggctaaatgg ataaggtgct agtttgatca tttcgatagc ttgggttgca ccgactggat
     2821 ttttaatcaa gacaagggta cattccttgt caccgatatg aaaggtttct tggcgtccaa
     2881 agacagcacg gctcttgtca aatccctgtt tgatgagttg cgaatcggca cctaggaaac
     2941 gggcgatggc cacagcagct agggcgttat agatattata gagcccgccg atttggatac
     3001 cgtattcttg gccgtctatg acaaagcgag agcgattgtt ggtcaactca accagttttg
     3061 tcaaacgata gtcgagatca ggacgtttgc atccacaacc ttcacagata taggcaccca
     3121 agtttgcata ggtattatgc tcatatttga ggatgccttg gcagtcagga cagagaatcc
     3181 cttcggtatt gtagtgagcc agttgggctg gtcctttttc caagtcaaaa ccaaaatact
     3241 ctatagggtt tggaatagtt ggcttgtaga aaagtggact gtctccgtta aggagaacag
     3301 tagcagttgg aactttccga atggcatcca atatcatgtt ataggtagta tagatttcac
     3361 cgaaacggtc catctggtca cggaagatat tagtaatgac aaaaagacta ggctggatat
     3421 agtcacagat acgagataga ctggcttcgt caatttcgag gacggcaata tttttcccag
     3481 tttttgaaga tttggctgtt aggaaggttg ttgcaatccc tgtaatcatg ttggcaccgc
     3541 ttgggttggt tagaacttga ccataaacct cttttaaaat gccgacagtg agggcagttg
     3601 tcagggtttt tccatttgtt ccagtgacaa cgacaatctc gtagttctta gctaggtttt
     3661 gtaaaatatc tttatcaaat tgaagggcga ctttacctgg gagcgtactt ccacggccaa
     3721 gacggcttaa aatgaagtgg gaagaacgcc cagcaagaag gcccaaagta gtttttaagt
     3781 tcatgtttct attatatcat aaaagaggag aaagacagat ttgagattcc gcagaagtaa
     3841 aaacagccca aagagggctg ttcgatacga ttaaatctca acttaaatcg caaacaagtc
     3901 attcaagttc tcagccaagg ttgggtgagt gaagatttgt tttgtgaagt aagtgtaagg
     3961 aatcttgttg tccatagcaa cagtgatgat gttgatgatt tcttgagaac cttctgagaa
     4021 gatgcttgct ccaagaattt cttttgtttc agtattgaca acagctttga aggcaccgcg
     4081 aaggtctcca tttacgtgac cacgaggcat tgctgtaacg gggatttcct taacagcgta
     4141 tggaagtttc aaatcagctg cttggctttc agtcaaacca acttgtgaaa gtgcaggtgt
     4201 gatgaacata gtatttggca cattgagacg gtcttcaagt gtgtagctgc catctccagc
     4261 aaggtagctg taaacaacac ggaagtcatc aagtgaaatg taagtaaatt gaaggccacc
     4321 gttgacatct ccaactgcaa agacaccagg aacgtttgtt tgacagtgtt tgtctacttt
     4381 aatagcacca cgttcagtta gttcaatatc tgtattttca agttgaagtg gttctacatt
     4441 tggtttgcgt ccagttgcgt agagaagggc gtcgaaacgg taagtttcgt cttcagttac
     4501 gacaagcact tggtcaccat cgtttttgat ttcagtagta tggatatttt gaagcaattc
     4561 aatgccatct tcttccatgt attgtttagc aagagctgcg atggaaggtt ctgcacgagg
     4621 taggaatgta tccaaggcat ctaggactgt gaccttgctt ccaagtttgt tgtaaaggcc
     4681 ggcaaattca agaccgatat ttccgccacc aaggattcca agtttttcag gtaatttgtc
     4741 caagctttgg atacctgttg agtcaaagat gtttttgctt gtagcaagtc cagggattgg
     4801 caagacgttt gaaacagcac cagtgttgat gacgattgtt tcagcagtca gttctttctt
     4861 ttcatcacca gcttggattt cgatgacttt atttgaaagg aagtgagctt ccgcatcaaa
     4921 gatatctacg cctgtaccag caacagtcgc atagttttta ccgttgaggc gaccagtgat
     4981 cgtgttttta gtagcaatga cttcttcaaa agacaagtcc ttttcagcag caactagcaa
     5041 ggttttagtt gggatacaac caatgttgat acaagttcca ccgtacatag ccttgctgcg
     5101 ttcaacgagg gcaacttttt tgccagctga agccaattta cctgctagtg ttttaccagc
     5161 tttaccaaat ccaataacaa ttaaatcgta tgttaacatt tatcttcctc ctattcgaat
     5221 ttcattctag cacaagaaaa aaacttttgc acaattctgc tacggaaaag acagaaaaag
     5281 ataaaaacgc tttccagaca aaaaactagt aattttttga caagcttgat aaactaaaat
     5341 cctatctatt tttatataag atagaataaa tgttcgaaaa taggaggttt tatgaaatcg
     5401 aatcgttata ttattgcctt tgctggggtc attttacact taatgctggg ttcgacttat
     5461 gcttggagtg tttatcgtaa ccctattatt gaaaaaacgg gatgggatca ggcttctgtt
     5521 gccttcgcct ttagtctagc aatcttttgt ttgggcttat cggctgcatt tatggggcgt
     5581 ttggtagaaa aatttggtcc gaaagtcatg ggaagtctat ctgcttttct atacgcaggt
     5641 ggaaatatct taacaggatt tgcaatagac cgtcaggagc tgtggttgtt gtatctcgct
     5701 tatggcattt taggtgggct tggtttggga gcaggctata ttacccctgt gtcgacgatt
     5761 ataaaatggt ttcctgataa acgtggtctc gcaacaggtt tagcgattat ggggtttggt
     5821 tttgcttctt tattgactag tcccatagcg caacacctca tcgcaggggt agggcttgta
     5881 gaaacttttt atattttagg agcaagttac tttattatca tgctcctagc ttcacaattc
     5941 attaagcgtc caaatgagca agagcttgca attttatctt cttcagggaa agaaaaaaca
     6001 gcctctttga cgcaaggaat ggctgcaaat caggctctaa aaagcaatcg gttttatatg
     6061 ctttggatta ttttctttat caacatagct tgtggtttag gcttaatttc agcggcatcg
     6121 ccaatggcac aggagatggc tggcttgtct acaagtcatg cagcagtaat ggtgggtgtt
     6181 ttggggattt tcaatggatt tggtcgcttg ctctgggcga gtttgtctga ctatatcggt
     6241 cgccctctaa cctttagtat attactgctt gtcaatcttt tcttttctct ctcactttgg
     6301 ctctttacag attccgtttt atttgtagtt gctatgtcta ttttgatgac ttgctatgga
     6361 gctggttttt ctttgattcc agcttatctc agtgatattt ttggaaccaa ggaattggcc
     6421 gctctgcatg gttatatttt aacagcttgg gcaatggctg gtttagcggg acctatttta
     6481 ttagcagaga cttataaaat ggctcattcg tacacacaaa ccttgttcgt ttttctcatt
     6541 ttatacagta tcgccttggc tttgtcttat tatctaggtc gttcaatcaa aaaagaaagt
     6601 caaaaagcgc ttacatgatt ttctgtagaa atggggctat cttttgctct ggtcttgtgt
     6661 tatactagat aggttgcaaa gaaaacagta cttttctttt gtggaaaaga agcaacacga
     6721 ttttatatct agttatatga aaatacgtca taaaaagaaa agtataaact aagccctata
     6781 gggtggcttc gcaccacctt tagaaagaag aataacgtga aatttaatga attaaacttg
     6841 tctgctgatt tgctagcaga aattgaaaaa gctggttttg tagaagctag tcctatccaa
     6901 gaacaaacta ttcctttggc ccttgaaggc aaggatgtta tcggtcaagc tcagactggt
     6961 acaggaaaaa ctgcagcctt tggcttgcct acccttgaaa aaatccgtac agaagaagcg
     7021 actatccaag ccttggtcat cgctccaact cgtgaactag ctgtccaaag tcaagaagaa
     7081 ctcttccgct ttggtcgtag taagggagtc aaagtccgtt cagtatatgg cggatcaagc
     7141 attgaaaaac aaattaaggc tcttaaatct ggtgcccata ttgtggtggg aactccaggt
     7201 cgcctcttgg acttgattaa acgcaaggcc ttgaaattac aagacattga aacccttatc
     7261 cttgacgaag cggatgaaat gcttaacatg ggcttccttg aagacatcga agccattatt
     7321 tcccgtgtac ctgagaaccg tcaaactttg cttttctcag caactatgcc agatgccatc
     7381 aaacgtatcg gtgttcagtt tatgaaagcc cctgaacatg tcaagattgc ggctaaggaa
     7441 ttgacaacag aattggttga ccagtactat atccgtgtta aggaacaaga aaaatttgac
     7501 accatgactc gtctcatgga tgtggcacaa ccagaactcg ctattgtatt tggtcgtacc
     7561 aaacgccgtg tggatgaatt gactcgtggt ttgaaaattc gtggcttccg tgcagaagga
     7621 attcatggcg acctagacca aaacaaacgt cttcgtgtcc ttcgtgactt taaaaatggc
     7681 aatcttgatg ttttggttgc gacagacgtt gcagcgcgtg gtttggatat ttcaggtgtg
     7741 acccatgtct acaactacga tattccacaa gatcctgaga gttatgttca ccgtatcggt
     7801 cgtacaggtc gtgctggtaa gtcaggtcaa tctattactt ttgttgctcc aaacgaaatg
     7861 ggttaccttc aaatcattga aaacttgact aagaaacgca tgaaaggtct caaacctgca
     7921 agtgtagaag aatccttcca atcaaaaaaa caggtagctc tcaagaaaat cgaacgtgat
     7981 tttgcagatg aaaccattcg tgccaacttt gagaaatttg gtaaggatgc tcgcaaattg
     8041 gctgctgagt ttactccaga agaattggca atgtatatct tgagtctgac agtccaagac
     8101 ccagatagcc ttccagaagt ggagattgca cgtgaaaaac cactaccgtt taaaccatca
     8161 ggtaatggtt tcggtggtaa agctaaggga ggtcgtggag gccgtcgtgg ggacgaccgt
     8221 cgagagcgtg atcgccgtgg caatggtcgc cgtgatgagt tcaaaaaagg aagtcgtggc
     8281 aacgatcgtt ttgataagga aaaacgttac cgtaaggata ataaaaaacc acgcaatact
     8341 ttaagcgaaa agcaaacagg ctttgttatt cgtaacaaag gcgataaata agaaaaagcg
     8401 gttcaaaatg aatcgctttt ttatataagg agaccgaatg tgaaaagaca aataaaatta
     8461 ttatattatc ttttataatg ttataataca caaaaatagg caacttgtca atagaaaagg
     8521 aacaatttaa ttaaaaatat tctggttttt aattaaattg taagtcaatg caagtcaata
     8581 aggaattttc agataattat tgaaaa
//
LOCUS       DAVLHC010000070         8395 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.071, whole genome shotgun sequence.
ACCESSION   DAVLHC010000070 DAVLHC010000000
VERSION     DAVLHC010000070.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 8395)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8395)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8395
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.071"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(<1..809)
                     /gene="folK"
                     /locus_tag="VXE25_001936"
     CDS             complement(<1..809)
                     /gene="folK"
                     /locus_tag="VXE25_001936"
                     /EC_number="2.7.6.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-amino-4-hydroxy-6-
                     hydroxymethyldihydropteridine diphosphokinase"
                     /protein_id="HEV0772344.1"
                     /translation="MDQLQIKDLEMFAYHGLFPSEKELGQKFVVSAILSYDMTKAATD
                     LDLTASVHYGELCQQWTTWFQETSEDLIETVAYKLVERTFESYPLVQEMKLELKKPWA
                     PVHLSLDTCSVTIHRRKQRAFIALGSNMGDKQANLKQAIDKLRARGIHILKESSVLAT
                     EPWGGVEQDSFANQVVEVETWLPAQDLLETLLAIESELGRVREVHWGPRLIDLDLLFV
                     EDQILYTDDLILPHPYIAERLFVLESLQEIAPHFIHPILKQPIRNLYDALK"
     gene            complement(852..1406)
                     /gene="folE"
                     /locus_tag="VXE25_001937"
     CDS             complement(852..1406)
                     /gene="folE"
                     /locus_tag="VXE25_001937"
                     /EC_number="3.5.4.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006155259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP cyclohydrolase I FolE"
                     /protein_id="HEV0772345.1"
                     /translation="MDRQKIEAAVKMIIEAVGENANREGLQETPARVARMYQEIFSGL
                     GQTAEEHLSKSFEIIDDNMVVEKDIFFHTMCEHHFLPFYGRAHIAYIPDGRVAGLSKL
                     ARTVEVYSKKPQIQERLNIEVADALMDYLGAKGAFVVIEAEHMCMSMRGVRKPGTATL
                     TTVARGLFETDKDLRDQAYRLMGL"
     gene            complement(1399..2709)
                     /locus_tag="VXE25_001938"
     CDS             complement(1399..2709)
                     /locus_tag="VXE25_001938"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000658404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional folylpolyglutamate
                     synthase/dihydrofolate synthase"
                     /protein_id="HEV0772346.1"
                     /translation="MKEIENNQWIANYRTDQPHFGLERMVELLALRGNPHLKLKVLHI
                     GGTNGKGSTIAFLKKMLEKLGLRVGVFSSPYLIHYTDQISINGESISEARLEALMADY
                     QSLLEGEAVANLQGTTEFEIITALAYDYFASEQVDVAIMEVGMGGLLDSTNVCQPILT
                     GITTIGLDHVALLGDTLEAIAEQKAGIIKQGMPLVTGRIAPEALTVIDRIAEGKDAPR
                     LAYGTDYQVRHQESVVTGEVFDYTSAVRQGRFQTSLLGLYQIENAGMAIALLDTFCQE
                     DGRELASNDFLGQALEETSWPGRLEIVSRDPLMILDGAHNPHAIKALLVTLQERFADY
                     HKEILFTCIKTKALEDMLDLLGAMPDTELTLTHFADSRATDESVLKEAAKARNLSYQD
                     WHDFLEQNLTDKKEEKQTVRIVTGSLYFLSQVRAYLMERKNENG"
     gene            complement(2711..3685)
                     /gene="folP"
                     /locus_tag="VXE25_001939"
     CDS             complement(2711..3685)
                     /gene="folP"
                     /locus_tag="VXE25_001939"
                     /EC_number="2.5.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydropteroate synthase"
                     /protein_id="HEV0772347.1"
                     /translation="MMKILEGVTDMSSKANHAKTVICGIINVTPDSFSDGGQFFALEQ
                     ALQQARKLIAEGASMLDIGGESTRPGSSYVEIEEEIQRVVPVIKAIRKESDVLISIDT
                     WKSQVAEAALAAGANLVNDITGLMGDEKMAHVVAKAGAKVVIMFNPVMARPQHPSSLI
                     FPHFGFGQTFTEKELADFETLPIEDLMVAFFERALARAAEAGIAPENILLDPGIGFGL
                     TKKENLLLLRDLDKLHQKGYPIFLGVSRKRFVINILEESGFEVNPETELGFRNRDTAS
                     AHVTSIAARQGVEVVRVHDVASHRMAVEIASTIRLADEAENLDLKQYK"
     gene            complement(3780..4487)
                     /locus_tag="VXE25_001940"
     CDS             complement(3780..4487)
                     /locus_tag="VXE25_001940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260476.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEV0772348.1"
                     /translation="MKEKNMWKELLNRAGWILVFLLAVLLYQVPLVVTSILTLKEVAL
                     LQSGLIVAGLSIVVLALFIMGARKTKLASFNFSFFRAKDLARLGLSYLVIVGSNILGS
                     ILLQLSNETTTANQSQINDMVQNSSLISSFFLLALLAPICEEILCRGIVPKKIFRGKE
                     NLGFVVGTIVFALLHQPSNLPSLLIYGGMSTVLSWTAYKTQRLEMSILLHMIVNGIAF
                     CLLALVVIMSRTLGISV"
     gene            complement(4540..5958)
                     /locus_tag="VXE25_001941"
     CDS             complement(4540..5958)
                     /locus_tag="VXE25_001941"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000359314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NCS2 family permease"
                     /protein_id="HEV0772349.1"
                     /translation="MDKLFKLKENGTDVRTEVLAGLTTFFAMSYILFVNPQILSQTGM
                     PAQGVFLATIIGAVAGTLMMAFYANLPYAQAPGMGLNAFFTFTVVFGLGYSWQEALAM
                     VFICGIISLVITLTNVRKMIIESIPNALRSAISAGIGVFLAYVGIKNAGLLKFTIDPG
                     NYTVVGEGADKAQATIAANSSAVPGLVSFNNPAVLVALAGLAITIFFVIKGIKGGIIL
                     SILTTTVLAIAAGLVDLSSIDFANNHVGAAFEDLKTIFGAALGSEGLGALVSDTARLP
                     ETLMAILAFSLTDIFDTIGTLIGTGEKVGIVATNGENHQSAKLDKALYSDLIGTTVGA
                     IAGTSNVTTYVESAAGIGAGGRTGLTALVVAICFAISSFFSPLLAIVPTAATAPILII
                     VGIMMLGSLKNIHWDDMSEAVPAFFTSIFMGFSYSITQGIAVGFLTYTLTKLVKGQVK
                     DVHAMIWILDALFILNYISMAL"
     gene            6148..6960
                     /locus_tag="VXE25_001942"
     CDS             6148..6960
                     /locus_tag="VXE25_001942"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000162344.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEV0772350.1"
                     /translation="MTKKIIAVDLDGTLLNSDSQISDFTKKTIKKVAEKGHQVIITTG
                     RPYRMSKDFYRELGLDTPMINFNGSLTHLPDQVWDFEKCLTVDKKYLLDMVQRSEDIQ
                     ADFIAGEYRKKFYITNPNEEIANPKLFGVEAFQPEDQFQPELVTKDPNCILLQTRASD
                     KYALAKDMNAFYQHQLSINTWGGPLNILECTPKGVNKAFALDYLLKIMNRDKKDLIAF
                     GDEHNDTEMLAFAGKGYAMKNANPELLPYADEQISLTNDQDGVAKTLQDLFL"
     gene            7299..8318
                     /gene="adhP"
                     /locus_tag="VXE25_001943"
     CDS             7299..8318
                     /gene="adhP"
                     /locus_tag="VXE25_001943"
                     /EC_number="1.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alcohol dehydrogenase AdhP"
                     /protein_id="HEV0772351.1"
                     /translation="MKAVVVNPESTGVAIEEKVLRPLETGEALVEVEYCGVCHTDLHV
                     AHGDFGQVPGRVLGHEGIGIVKEIAPDVKSLKVGDRVSVAWFFEGCGTCEYCTTGRET
                     LCRTVKNAGYSVDGGMAEQCIVTADYAVKVPDGLDPAQASSITCAGVTTYKAIKEAKV
                     EPGQWVVLYGAGGLGNLAVQYAKKVFNAHVIAVDINNDKLALAKEVGADIVINGLEVE
                     DVAGLIKEKTDGGAHSAVVTAVSKVAFNQAVDSVRAGGRVVAVGLPSEMMELSIVKTV
                     LDGIQVIGSLVGTRKDLEEAFQFGAEGLVAPVVQKRPVEDAVAIFDEMEKGQIQGRMV
                     LDFTH"
BASE COUNT         2493 a         1955 c         1639 g         2308 t
ORIGIN      
        1 tttttcaaag catcatacaa gttgcggatc ggttgtttta atatcggatg gataaaatga
       61 ggcgcaattt cctgtaagga ctcaaggaca aaaaggcgtt ccgctatgta aggatgaggc
      121 aatatgaggt cgtctgtata aaggatctgg tcctccacaa agagcaagtc caaatcaatc
      181 aaacgaggtc cccaatgcac ttctctcacc cgtcccagct ctgactcaat ggctaacaag
      241 gtttctaaca agtcttgtgc tggtagccag gtttccacct caaccacttg attggcaaag
      301 ctatcctgct ccactccacc ccaaggctcc gtcgctaaga cactggactc tttgagaata
      361 tggatgccac gagctcgcag tttgtcaatg gcttgcttca agtttgcttg tttatctccc
      421 atattgcttc ctagggcgat aaaggctcgt tgcttgcggc gatgaatggt taccgagcaa
      481 gtatctagtg acaaatgcac cggtgcccaa ggttttttca gttccaactt catttcttgg
      541 acaagaggat aagactcaaa ggtacgttcc accagtttat aggctaccgt ttcaatcaaa
      601 tcttcactcg tttcctgaaa ccaagtcgtc cactgctgac acaattctcc gtaatggaca
      661 gaggctgtta aatccaagtc tgtagctgcc ttggtcatat cataggatag gatggctgaa
      721 acgacaaatt tctgccccaa ttctttctca ctaggaaaaa gaccatgata ggcaaacatt
      781 tccaaatcct taatctgcag ttgatccata atgattcctt tctagaaaaa tccgcttgaa
      841 gcggattctt tttatagccc cattaaacga taagcttggt cacggagatc cttatctgtt
      901 tcaaatagac cacgagctac tgtcgtcaag gttgcagtgc ctggttttct aacaccacgc
      961 atactcatac acatatgttc cgcctcaatg acaacaaagg ctcctttagc acctagatag
     1021 tccatcaagg catcggccac ttcgatattc aaacgttctt gaatttgtgg ttttttcgaa
     1081 taaacttcaa ccgtacgggc tagcttagac aagcctgcca cacgaccatc tggaatgtag
     1141 gcaatgtgcg ctctaccata aaatggcaag aagtggtgtt cacacatggt atggaaaaag
     1201 atatcctttt ctaccaccat attatcgtca ataatttcaa aggattttga caaatgttcc
     1261 tctgctgttt gaccaagacc tgaaaaaatc tcttgataca tacgggctac acgagcaggt
     1321 gtttcctgca agccctcgcg attagcgttc tctcctacag cctcgataat catttttaca
     1381 gctgcttcaa tcttttgtct atccattctc gttcttcctc tccatcagat aggccctcac
     1441 ttggctcaag aaatacaagg aacctgtgac aatcctaact gtttgtttct cttctttttt
     1501 atctgtcaaa ttctgctcta gaaaatcatg ccaatcttgg tagctgagat ttctagcctt
     1561 agctgcctct ttcagcacgc tttcatccgt cgcccgacta tccgcaaaat gtgttagagt
     1621 aagctcggta tctggcatgg ctcccagcaa gtccaacata tcctccaagg ctttggtttt
     1681 gatacaagtg aagaggattt ccttatgata atccgcaaaa cgttcttgca aggttaccaa
     1741 caaggccttg atagcatggg gattatgggc tccatccaaa atcatcaagg gatctcttga
     1801 cacgatttcc aaacgccctg gccaacttgt ttcttccaag gcttgaccaa gaaaatcatt
     1861 gcttgctagc tctcgaccat cttcttgaca aaaagtatca agtaaagcta tggccatccc
     1921 agcattctct atttggtaca aaccaagcag gctagtctgg aagcgacctt gtctgacagc
     1981 acttgtatag tcaaagactt cccctgtcac cacactttct tgatgacgaa cctgataatc
     2041 tgtcccgtag gcaagtctcg gcgcatcttt cccttccgca atgcggtcaa tcacagtcaa
     2101 ggcttctgga gcaatacgcc ctgttaccaa gggcatccct tgtttgataa tacctgcctt
     2161 ctgctctgct atggcctcca aggtgtcacc aagtagggcc acatgatcca agccaatagt
     2221 tgtaattcct gtcaaaatgg gctgacagac attggtacta tccaaaagtc cacccatgcc
     2281 aacttccatg atagccacat ctacttgctc tgaggcaaag tagtcatagg ctagggctgt
     2341 gataatctca aactcggttg tgccctgtaa attggcgacc gcttctccct ccagcaaaga
     2401 ctgatagtct gccatgagag cttctagcct cgcttctgag atcgattccc cattgatgct
     2461 aatctggtct gtgtaatgaa tgagataggg cgaactaaac acgccaactc tcagccctag
     2521 cttttctagc atctttttca aaaaagcaat agtcgagccc ttgccgttag tccctccgat
     2581 atggaggacc ttgagtttga gatggggatt gccacgcaaa gctaacagtt ccaccattcg
     2641 ttccaagcca aaatgcggtt gatccgtccg gtagttagca atccactgat tgttttcaat
     2701 ttctttcatc ttatttatat tgttttaaat ctaaattttc cgcttcatca gccagacgaa
     2761 tggtagaggc aatttcaact gccatcctgt gactagctac gtcatgcacg cgcaccactt
     2821 ctacaccctg tctcgcagca atactagtta catgagccga agccgtgtcc cgatttcgga
     2881 aaccaagctc tgtctcagga ttgacttcaa acccactttc ttcaaggata ttgatgacaa
     2941 atcgcttgcg cgacactccg agaaagattg gatagccctt ctgatgtagt ttatccaggt
     3001 cccgtaaaag gaggagattt tctttcttgg tcagaccaaa gccaattcct ggatccaaca
     3061 ggatattttc tggtgcaata ccagcttctg ccgctctcgc tagtgctcgt tcaaagaaag
     3121 ccaccatcaa gtcttcgatt ggcaatgttt caaagtcagc taactctttt tctgtaaagg
     3181 tttgaccaaa accaaaatga gggaagataa gcgaactagg atgctgaggt cgagccataa
     3241 ctgggttaaa catgatgacc actttcgctc cagctttagc aaccacatgg gccatttttt
     3301 catcacccat gagaccagtg atatcattaa ctagattggc accagcagcc aaagcagcct
     3361 ctgccacctg acttttccaa gtatcgatag aaataaggac atcgctttcc ttgcgaatcg
     3421 ctttgatcac tggaacaaca cgctggattt cctcttctat ctcaacatag ctacttcccg
     3481 gccgagtcga ttctccgccg atatctagca tactggctcc ttctgcgatc aacttccgag
     3541 cctgctggag cgcctgctca agagcaaaaa attgaccacc gtccgaaaag gagtctgggg
     3601 ttacattgat aattccgcaa ataactgtct ttgcatgatt ggctttactt gacatatcgg
     3661 tcactccctc aaggattttc atcatattat ttttctattt taccataaaa agaaaaagat
     3721 ggacacgatt gcattcatct ttccctagta gaaagaggtc ggttcctaca taaaaacttt
     3781 taaacagaaa ttcctaatgt ccgactcata atcaccacaa gagccaacaa acagaaagca
     3841 atcccattaa caatcatgtg aagcaagatc gacatttcca aacgttgggt cttgtaggct
     3901 gtccaagata gaactgtcga catacctcca taaatcaata aagaaggtaa attacttggt
     3961 tgatgcaata aagcaaacac aatcgtaccg actacaaatc ccaagttctc cttgcctcgg
     4021 aaaatctttt taggaacaat cccacgacac aagatttcct cacaaatcgg agcaagcaag
     4081 gctagcaaga agaaactgga aatcaacgaa ctattttgaa ccatatcatt aatctgagac
     4141 tggttagctg ttgtcgtctc atttgacagt tgcaataaaa tggaaccaag tatatttgac
     4201 ccgacaataa ctagataact caagcccaaa cgtgccaaat ctttagctct aaaaaaagaa
     4261 aaattaaaac tagctaactt ggttttacga gctcccataa taaatagagc cagaaccaca
     4321 attgaaaggc cagcaactat cagccctgac tgtagcaggg ctacttcttt taaagtcaaa
     4381 atagaggtaa ccactagggg aacctgatat aaaaggacgg caagtaaaaa gaccaaaatc
     4441 cagcctgcac gattcaacaa ttctttccac atatttttct ctttcatcac ctatctcctt
     4501 tgtattaaaa aaggggggaa atccccctgg gtcattctat tataaggcca tgctgatgta
     4561 gttaaggata aacaaggcat ccaaaatcca aatcatggca tgaacatctt taacttgacc
     4621 tttgacaagc ttagtcaaag tgtaagtcaa gaaaccaact gcaatccctt gagtgataga
     4681 gtagctgaat cccataaaga tagatgtgaa gaaggcagga actgcttcag acatatcatc
     4741 ccaatggata tttttcaagc taccaagcat cataatccca acgataatca agattggagc
     4801 tgtagccgct gttggtacga tcgctagaag tgggctaaag aagcttgaaa tcgcaaaaca
     4861 gatagctaca accaaggctg tcaaaccagt acgtccacct gcaccgatac cagcagcaga
     4921 ctcaacataa gtcgttacgt ttgaagtacc tgcaatggca ccgactgtcg ttccaatcaa
     4981 atcagagtaa agagccttat ccaatttggc tgattggtga ttttcaccat ttgtcgctac
     5041 aataccaact ttttcacctg taccgatcaa ggtaccaatt gtgtcaaaaa tatctgtcaa
     5101 tgagaaggca agaatggcca tcagagtttc aggcaagcga gctgtatctg aaaccaaagc
     5161 tcccaaacct tctgaaccaa gagctgcacc aaagattgtc ttcaaatctt caaaagctgc
     5221 accaacatgg ttattagcaa aatcgatact agacaaatca accaaaccag ctgcaatagc
     5281 aagaacagtt gttgtcaaga tagagagaat aattccccct ttaatccctt tgatgacaaa
     5341 gaagatagta atggcaagtc ctgcaagagc cactaaaaca gctggattat taaagctgac
     5401 caatcctgga actgctgaag agtttgctgc aatcgttgct tgagctttgt cagccccttc
     5461 tcctacaaca gtatagttgc ctggatcaat cgtaaatttc aaaagtccag cattcttaat
     5521 ccctacatag gcaaggaaga caccgatacc agctgaaata gccgagcgaa gggcatttgg
     5581 aatcgattca atgatcattt tacgaacatt tgtcaaggta ataaccaatg aaataatccc
     5641 acagatgaag accatagcta gggcttcttg ccatgaataa ccaagtccaa atacgactgt
     5701 aaaggtaaag aaggcattga gtcccatacc tggtgcttga gcgtatggca agttagcata
     5761 gaaggccatc atcaaggtac cagcaactgc accgataatc gttgcaagaa acacaccctg
     5821 agcaggcatt cctgtttgtg aaagtatttg tgggtttaca aagagaatat agctcattgc
     5881 aaagaaagtt gttaaaccag cgagaacctc tgtacgaacg tctgtaccgt tctcttttag
     5941 tttaaataat ttgtccatca tcaatctcct tttaattttt acgaacaata atagaattat
     6001 atcatttatc attcactttt tcaatgtctt tgtttgattt gtttaagaaa ttaatccaat
     6061 ttcatttttt gtttggaatc tgcttttctg cctgctttct gttataatag aagacatctt
     6121 atctgaaaac acactagaaa ggtccatatg acgaaaaaaa ttattgcagt tgacctagat
     6181 ggaaccctgc tcaactcaga cagtcaaatt tctgacttta ccaaaaaaac catcaaaaaa
     6241 gttgctgaaa aaggccatca ggttattatt acgacaggtc gcccttaccg tatgtcaaaa
     6301 gatttttacc gtgaactggg cttagacact cctatgatta acttcaacgg atcccttact
     6361 catttaccag accaagtttg ggattttgaa aagtgtttga ctgtagacaa aaaatatctg
     6421 ctagatatgg ttcaacgttc agaggacatt caagccgatt ttatcgctgg agaatatcgt
     6481 aaaaaattct acattacaaa tcccaatgaa gaaattgcca atcccaaact atttggtgta
     6541 gaagctttcc agcctgaaga tcaattccag cctgaattgg tgaccaagga ccctaactgt
     6601 atcctcttgc agaccagagc cagtgacaaa tatgccttgg caaaagacat gaacgccttc
     6661 taccagcatc aactttctat caatacctgg ggaggtccgc tcaatatcct tgaatgtacc
     6721 ccaaaaggtg tcaacaaggc ctttgctttg gactacttgc tcaagataat gaatcgtgac
     6781 aaaaaagatt tgattgcctt tggagatgaa cacaatgata ccgaaatgct cgcttttgct
     6841 gggaagggtt atgccatgaa aaatgccaat ccagagctac tcccttatgc agatgagcaa
     6901 atttccctta ccaacgacca agatggggtt gccaaaaccc tacaagactt attcttataa
     6961 cctatactga tactcaatga gaatcaaaga gcaaactagg aagctagccg taggttgctc
     7021 aaagcactgc tttgaggttg tagatgaagc tgacgtggtt tgaagagatt ttcgaagagt
     7081 atgaccagct tgcaagctgg tctttgtgct cttttcacag tctcatcaac cagttaatcg
     7141 attgttctac tttttgtctc caaaaccttg gaaaaggctt tcttttgtga tatacttcac
     7201 atataaatac aagagagctc gtcacactcg actctgttga caaaaaatca atccagtccc
     7261 gttgtccctg ttctcggtca atatcaagga ggatagctat gaaagctgtt gttgtaaatc
     7321 cagaaagcac tggtgttgct attgaagaaa aagtactccg tccacttgaa actggggaag
     7381 cacttgtaga agttgaatac tgtggcgttt gccacaccga cctccacgtt gctcatggtg
     7441 actttggtca agtcccagga cgtgttcttg ggcacgaagg tatcggtatc gttaaagaga
     7501 ttgctccaga tgtgaaaagc cttaaagtcg gtgaccgcgt cagcgttgct tggttctttg
     7561 aaggatgtgg cacttgcgaa tactgtacaa ctggtcgcga aaccctttgc cgtacagtga
     7621 aaaatgctgg ctactcagta gacggtggta tggctgaaca atgtatcgta actgctgact
     7681 atgctgtcaa ggttcctgac ggacttgatc cagcccaagc ttcttctatc acatgtgctg
     7741 gagtaacaac ctataaagct atcaaagaag caaaagttga accaggccaa tgggttgttc
     7801 tttacggtgc tggtggactt ggtaacctcg ctgttcaata cgctaaaaaa gtattcaatg
     7861 ctcatgttat cgcagtcgat atcaacaatg acaaacttgc ccttgcaaaa gaagtaggcg
     7921 ctgacattgt gattaacggc ctcgaagttg aagatgtagc tggactcatc aaagaaaaaa
     7981 ctgatggagg agctcattca gctgtcgtaa ctgctgtgtc taaagttgcc ttcaaccagg
     8041 ctgttgactc cgttcgtgct ggtggtcgcg tcgtcgctgt tggtcttcct tctgaaatga
     8101 tggaactcag catcgttaaa acagtcctcg atggaatcca agtcatcggt tctcttgtcg
     8161 gaactcgtaa agacttagaa gaagccttcc aatttggtgc agaaggtctg gtagccccag
     8221 ttgttcaaaa acgtccagta gaagatgctg ttgccatttt cgacgaaatg gaaaaaggtc
     8281 aaatccaagg acgtatggta ctcgacttca cccactaatc taatagaaac ctattttcaa
     8341 agttggaagc ttcttccaac ttttttatat taaattttta aataagaatt caaga
//
LOCUS       DAVLHC010000071         7777 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.072, whole genome shotgun sequence.
ACCESSION   DAVLHC010000071 DAVLHC010000000
VERSION     DAVLHC010000071.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 7777)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7777)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7777
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.072"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(52..3894)
                     /gene="spuA"
                     /locus_tag="VXE25_001944"
     CDS             complement(52..3894)
                     /gene="spuA"
                     /locus_tag="VXE25_001944"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG-anchored pullulanase SpuA"
                     /protein_id="HEV0772352.1"
                     /translation="MRKTPSHTEKKMVYSIRSLKNGTGSVLIGASLVLLAMATPTISS
                     DESTPTTNEPNNRNTTTLAQPLTDTAAGSGKNESDISSPRNANASLEKTEEKPATSPA
                     DPAPQTGQDRSSEPTTSTSPVTTETKAEEPIEDNYFRIHVKKLPEENKDAQGLWTWDD
                     VEKPSENWPNGALSFKDAKKDDYGYYLDVKLKGEQAKKISFLINNTAGKNLTGDKSVE
                     KLVPKMNEAWLDQDYKVFSYEPQPAGTVRVNYYRTDGNYDKKSLWYWGDVKNPSSAQW
                     PDGTDFTATGKYGRYIDIPLNEAAREFGFLLLDESKQGDDVKIRKENYKFTDLKNHSQ
                     IFLKDDDESIYTNPYYVHDIRMTGAQHVGTSSIESSFSTLVGAKKEDILKHSNITNHL
                     GNKVTITDVAIDETGKKVTYSGDFSDTKHPYTVSYNSDQFTTKTSWRLKDETYSYDGK
                     LGADLREEGKQVDLTLWSPSADKVSVVVYDKNDPDKVVGTVALEKGERGTWKQTLDST
                     NKLGITDFTGYYYQYQIERQGKTVLALDPYAKSLAAWNSDDAKIDDAHKVAKAAFVDP
                     AKLGPQDLTYGKIHNFKTREDAVIYEAHVRDFTSDPAIAKDLTKPFGTFEAFIEKLDY
                     LKDLGVTHIQLLPVLSYYFVNELKNHERLSDYASSNSNYNWGYDPQNYFSLTGMYSSD
                     PKNPEKRIAEFKNLINEIHKRGMGAILDVVYNHTAKVDIFEDLEPNYYHFMDADGTPR
                     TSFGGGCLGTTHHMTKRLLVDSIKYLVDTYKVDGFRFDMMGDHDAASIEEAYKAARAL
                     NPNLIMLGEGWRTYAGDENMPTKAADQDWMKHTDTVAVFSDDIRNNLKSGYPNEGQPA
                     FITGGKRDVNTIFKNLIAQPTNFEADSPGDVIQYIAAHDNLTLFDIIAQSIKKDPSKA
                     ENYAEIHRRLRLGNLMVLTAQGTPFIHSGQEYGRTKQFRDPAYKTPVAEDKVPNKSHL
                     LRDKDGNPFDYPYFIHDSYDSSDAVNKFDWTKATDGKAYPENVKSRDYMKGLIALRQS
                     TDAFRLKSLQDIKDRVHLITVPGQNGVEKEDVVIGYQITAPNGDIYAVFVNADEKARE
                     FNLGTAFAHLRNAEVLADENQAGSVGIANPKGLEWTEKGLKLNALTATVLRVSQNGTS
                     HESTAEEKPDSTPSKPEHQNEASHPAHQDPAPEARPDSTKPDAKVADAENKPSQATAD
                     SQAEQPAQEAQASSVKEAVRKESVENSSKENISATPDRQAELPNTGIKNENKLLFAGI
                     SLLALLGLGFLLKNKKEN"
     gene            4311..4724
                     /gene="rpsL"
                     /locus_tag="VXE25_001945"
     CDS             4311..4724
                     /gene="rpsL"
                     /locus_tag="VXE25_001945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002356190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S12"
                     /protein_id="HEV0772353.1"
                     /translation="MPTINQLVRKPRKSKVEKSKSPALNVGYNSHKKVQTNVSSPQKR
                     GVATRVGTMTPKKPNSALRKFARVRLSNLIEVTAYIPGIGHNLQEHSVVLLRGGRVKD
                     LPGVRYHIVRGALDTAGVNDRKQGRSKYGTKRPKA"
     gene            4744..5214
                     /gene="rpsG"
                     /locus_tag="VXE25_001946"
     CDS             4744..5214
                     /gene="rpsG"
                     /locus_tag="VXE25_001946"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S7"
                     /protein_id="HEV0772354.1"
                     /translation="MSRKNRAPKRDVLPDPLYNSQLVTRLINRVMLDGKRGTAASIVY
                     GAFEQIKEATGNDALEVFETAMENIMPVLEVRARRVGGSNYQVPVEVRPERRTTLGLR
                     WLVTIARLRGEHTMQDRLAKEILDAANNTGAAVKKREDTHRMAEANRAFAHFRW"
     gene            5639..7720
                     /gene="fusA"
                     /locus_tag="VXE25_001947"
     CDS             5639..7720
                     /gene="fusA"
                     /locus_tag="VXE25_001947"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor G"
                     /protein_id="HEV0772355.1"
                     /translation="MAREFSLEKTRNIGIMAHVDAGKTTTTERILYYTGKIHKIGETH
                     EGASQMDWMEQEQERGITITSAATTAQWNNHRVNIIDTPGHVDFTIEVQRSLRVLDGA
                     VTVLDSQSGVEPQTETVWRQATEYGVPRIVFANKMDKIGADFLYSVSTLHDRLQANAH
                     PIQLPIGSEDDFRGIIDLIKMKAEIYTNDLGTDILEEDIPAEYLDQAQEYREKLIEAV
                     AETDEELMMKYLEGEEITNEELKAGIRKATINVEFFPVLCGSAFKNKGVQLMLDAVID
                     YLPSPLDIPAIKGINPDTDAEETRPASDEEPFAALAFKIMTDPFVGRLTFFRVYSGVL
                     QSGSYVLNTSKGKRERIGRILQMHANSRQEIDTVYSGDIAAAVGLKDTTTGDSLTDEK
                     SKIILESINVPEPVIQLMVEPKSKADQDKMGIALQKLAEEDPTFRVETNVETGETVIS
                     GMGELHLDVLVDRMRREFKVEANVGAPQVSYRETFRASTQARGFFKRQSGGKGQFGDV
                     WIEFTPNEEGKGFEFENAIVGGVVPREFIPAVEKGLVESMANGVLAGYPMVDVKAKLY
                     DGSYHDVDSSETAFKIAASLSLKEAAKSAQPAILEPMMLVTITVPEENLGDVMGHVTA
                     RRGRVDGMEAHGNSQIVRAYVPLAEMFGYATVLRSASQGRGTFMMVFDHYEDVPKSVQ
                     EEIIKKNKGED"
BASE COUNT         2131 a         1561 c         1736 g         2349 t
ORIGIN      
        1 ttaatccccc gagctataat gcttggggga tttttctata ggagggctag cttagttctc
       61 ttttttattt tttagtaaga aaccgagacc aaggagcgca aggaggctga ttcctgcaaa
      121 taggagtttg ttttcgtttt tgattcctgt atttggaagt tcagcttgtc tatctggggt
      181 tgcagatata ttttccttgc tagagttttc taccgattct tttcgaaccg cttcttttac
      241 agatgatgct tgtgcttctt gtgctggttg ttcagcttgt gaatcagctg tagcttggct
      301 aggtttattt tccgcatcag ctactttggc atctggttta gtagaatcag gtctagcttc
      361 tggagctggg tcttgatgtg cagggtgaga agcttcattt tgatgttcag gcttggaagg
      421 ggttgagtct ggtttctctt ctgcagttga ctcatggcta gttccatttt gagagactcg
      481 aagaacagta gctgtaaggg cattcaattt caagcctttt tcagtccatt caagtccttt
      541 cgggttggca attccgactg atcctgcttg gttttcatct gccaaaactt ccgcatttct
      601 tagatgtgca aaggcagttc ccaaattaaa ttcgcgagct ttttcatccg cattgacaaa
      661 gactgcgtag atatcgccgt ttggagcagt gatttggtag ccaatcacta catcctcttt
      721 ttccacacca ttttggcctg ggacagtgat gaggtggaca cggtctttga tatcttggag
      781 actcttaagt cggaaggcat ctgtagattg acgaagggca atcaaacctt tcatatagtc
      841 acggctcttg acattttcag gataagcttt accatctgta gccttagtcc agtcaaactt
      901 gttgactgcg tcgctagaat cgtaagaatc atggatgaag taaggatagt caaatgggtt
      961 gccgtcctta tcacgcaaca agtgagattt gtttggaacc ttatcctctg ctactggagt
     1021 cttgtaggct gggtcacgga attgtttagt acgtccatat tcctgaccgg agtggataaa
     1081 tggagttcct tgagctgtca agaccatgag atttccaagt cgtaaacgac ggtggatttc
     1141 agcatagttc tcagccttgc ttgggtcttt tttgatagac tgggcaatga tgtcaaagag
     1201 ggtcaagtta tcatgggctg cgatgtattg gatgacatct ccagggctgt cagcttcaaa
     1261 gttagttggt tgagcaatga gatttttaaa gatggtgttg acatcacgct tgccacctgt
     1321 gataaaggca ggttgacctt cgtttggata accagatttg aggttgttac ggatgtcatc
     1381 tgaaaagaca gcgacagtat cggtatgttt catccaatct tggtcagcag ctttagtagg
     1441 catgttttca tcaccggcat aggttctcca accttcgcct aacatgatta gatttggatt
     1501 gagggcgcgt gcagccttgt aagcttcttc gatagaagcg gcgtcatggt ctcccatcat
     1561 atcgaagcgg aagccatcca ctttgtaggt atcaactagg tatttgatag agtcaactag
     1621 gagccgtttg gtcatatggt gggttgtccc caagcatcca ccaccaaagc tagttcgagg
     1681 tgtgccatcg gcatccataa agtggtagta gtttggctct aggtcttcaa agatatcgac
     1741 tttggctgtg tggttataaa cgacatctag gatagctccc ataccacgtt tgtggatttc
     1801 gttgatgagg tttttaaatt ctgcgattcg tttttctgga ttcttaggat cgcttgagta
     1861 cataccagtc aaggagaagt agttttgagg gtcatatccc cagttgtagt tgctgttgct
     1921 tgaagcatag tcagacaagc gttcatggtt tttcaattca ttgacaaagt agtaagacaa
     1981 gactggaagg agctggatat gggttacacc caagtctttg agatagtcta gtttttcaat
     2041 gaaggcttca aaagtcccaa atggtttggt caagtctttt gcaatggcag gatctgaagt
     2101 gaagtcacgc acatgagctt cgtagataac ggcgtcttca cgagtcttga aattgtgaat
     2161 cttaccataa gtcaagtctt gaggtccgag tttagctgga tctacaaagg cggctttagc
     2221 cactttatgg gcatcgtcaa tcttggcatc gtcgctattc caagcagcaa gagatttagc
     2281 gtaaggatcg agtgcaagaa cagttttacc ttgacgctcg atttggtatt gataatagta
     2341 gccagtgaaa tctgtgattc cgagtttgtt tgtgctgtct agagtttgtt tccaagttcc
     2401 tctttcccct ttttcgagag cgacagttcc aactactttg tcagggtcat tcttgtcgta
     2461 gacaacaaca gaaaccttat cagcacttgg tgaccaaagg gtcaaatcaa cttgttttcc
     2521 ttcttctctt aggtcagctc ccagtttgcc atcatagctg tatgtctcat ctttcaggcg
     2581 ccagcttgtt ttggtagtga attgatcgga attgtagcta acagtataag gatgttttgt
     2641 gtcagagaaa tctccgctgt aggtcacttt cttaccagtt tcatcgattg caacatcggt
     2701 aatagttacc ttgtttccta ggtgattagt gatgttggag tgtttgagga tatcttcttt
     2761 tttagcaccg acaagtgttg aaaagctact ttcaatgcta gaagtgccta cgtgttgggc
     2821 tcctgtcata cggatatcat ggacatagta tggatttgtg taaatcgatt catcatcgtc
     2881 ttttaggaaa atttggctat gatttttcaa atctgtgaac ttataatttt ctttacggat
     2941 tttcacgtcg tctccttgtt tgctctcatc tagtaataaa aatccaaatt ctcttgcggc
     3001 ttcattaaga ggaatgtcga tatagcggcc atatttgcct gtagccgtaa agtctgttcc
     3061 gtcaggccat tgagcgctac ttggattttt tacatctccc cagtaccaga gagatttctt
     3121 gtcatagttg ccatctgtgc ggtagtagtt gacgcgaaca gttcctgcag gctgtggctc
     3181 gtaagagaaa accttgtaat cttggtctaa ccaagcttcg ttcatttttg gaactagttt
     3241 ttctacagat ttatcgccgg ttagattttt tccagctgta ttgttgatga ggaagctaat
     3301 tttcttggct tgttctccct ttaatttgac atctaggtaa tagccgtagt catctttctt
     3361 ggcatccttg aaggacaaag ctccgtttgg ccagttttca gatggttttt caacatcgtc
     3421 ccaagtccat agtccttgag catccttgtt ttcttcagga agttttttga catggatacg
     3481 gaagtagtta tcttcgatgg gctcttctgc cttagtttca gttgttactg gactagtaga
     3541 agtagttggc tcacttgaac gatcttgtcc agtttgtggt gctggatcgg ctgggcttgt
     3601 agcaggtttt tcttctgttt tctctaggga agcgtttgca tttctaggtg aagaaatatc
     3661 actttcgttc ttaccagagc cagctgctgt atcagtaaga ggttgagcaa gggtggttgt
     3721 atttctgttg ttgggttcgt tagtggttgg tgtactttcg tcggatgaga tagttggtgt
     3781 agccatggca agcaagacaa ggcttgcgcc gataaggaca gaaccagttc catttttgag
     3841 ggaacggatg ctgtagacca tttttttctc agtgtgagat ggtgtttttc tcataatgat
     3901 tctccaatca ataaatttct atatcagtat agcatgtagt aaaacaatat gcaagcgttt
     3961 tctttgattt gtgaaaaaaa ttcctacttt tgagaagttt tctgtactat tttatatatc
     4021 agtataaatg acggagataa aaatgtcaca taagccaagc cgtattatta ggaagatgat
     4081 gtgttcccag ctatttttat tcagaaattg atctctaaca ttaccaataa aaatgaaaaa
     4141 tatcttgaca agcaagggaa aattttgtta caataataga cggtactttt tacttttggt
     4201 ctctcaagag tgtacaggga cgtgctgaca aatgttgcaa aagtacacac agatgatatc
     4261 tgtcaccaag tgtatcatca ccaaaaataa aaaaacacag gagaatgtag atgcctacaa
     4321 ttaaccaatt ggttcgcaaa ccgcgtaaat caaaagtaga aaaatctaaa tcaccagctt
     4381 tgaacgttgg ttacaatagt cataaaaaag ttcaaacaaa cgtttcttca ccacaaaaac
     4441 gtggtgttgc aactcgtgtt ggaacaatga cacctaaaaa acctaactca gcccttcgta
     4501 aattcgctcg tgtacgtttg agcaacctta tcgaagttac tgcctacatc ccaggtatcg
     4561 gacacaactt gcaagagcac agcgtggtgc ttcttcgcgg tggacgtgta aaagaccttc
     4621 caggggtacg ttaccatatc gtccgtggtg cacttgatac tgcaggtgtt aacgatcgta
     4681 aacaaggccg ttctaaatac ggtactaaac gtccaaaagc ataaggaaag gggataaaga
     4741 gaaatgagtc gtaaaaatag agctccaaaa cgtgacgtat tgccagatcc gctatacaat
     4801 tcacaactag ttactcgtct tatcaaccgc gttatgcttg atggtaaacg tggtactgct
     4861 gcttcaatcg tttacggtgc ttttgagcaa atcaaagaag ctactggcaa cgatgcactt
     4921 gaagtatttg aaacagctat ggaaaacatc atgcctgtac ttgaagtacg tgcacgtcgt
     4981 gttggtggtt ctaactacca agtcccagtt gaagttcgtc cagaacgtcg tacaacactt
     5041 ggacttcgtt ggttggtaac aatcgctcgt cttcgtggtg aacacacaat gcaagaccgt
     5101 cttgcaaaag aaatcttgga tgctgctaac aacactggtg cagcagttaa gaaacgtgaa
     5161 gatactcacc gtatggctga agctaaccgt gcattcgcac acttccgttg gtaagatagg
     5221 atgcgaaagc gttaagaaag tcccagagaa aatagggaat cgaagcaggt tgcggttgca
     5281 accaatgaga ttcatctttt tctccagact tttagcttga gctcaactaa atcatgatgc
     5341 taggcacggt aaggatgcaa ggtgaaaata ggaaactgac gcagtattca acgaatacaa
     5401 ggagttttat ctttttcacg cagcatcccg ttccagctca catcggctaa ctaactttag
     5461 cctgggttca aattagctaa atcgattagt attagctata actcagctta ccatctcgta
     5521 agttgaaacc aacaatagca tgaaaacatt gagaacgggt aggtcctgcc tatccgtttt
     5581 tattaaaatc gtgttataat agaatagaaa tcaaaaataa ataggagaaa caaacctcat
     5641 ggcacgcgaa ttttcacttg aaaaaactcg taatatcggt atcatggctc acgtcgatgc
     5701 cggtaaaaca acaactactg agcgtattct ttactacact ggtaaaatcc acaaaatcgg
     5761 tgaaactcac gaaggtgcgt cacaaatgga ctggatggag caagagcaag aacgtggtat
     5821 cacgatcaca tctgctgcga caacagctca atggaacaac caccgcgtaa acatcatcga
     5881 cacaccagga cacgtggact tcacaatcga agtacaacgt tctcttcgtg tattggatgg
     5941 tgcggttacc gttcttgact cacaatcagg tgttgaacct caaactgaaa cagtttggcg
     6001 tcaagcaact gagtacggag ttccacgtat cgtatttgcc aacaaaatgg acaaaatcgg
     6061 tgctgacttc ctttactctg taagcacact tcacgatcgt cttcaagcaa atgcacaccc
     6121 aatccaattg ccaatcggtt ctgaagatga cttccgtggt atcattgact tgatcaagat
     6181 gaaagctgaa atctatacta acgaccttgg tacggatatc cttgaagaag acatcccagc
     6241 tgaatacctt gaccaagctc aagaataccg tgaaaaattg attgaagcag ttgctgaaac
     6301 tgacgaagaa ttgatgatga aatacctcga aggtgaagaa atcactaacg aagaattgaa
     6361 agctggtatc cgtaaagcga ctatcaacgt tgaattcttc ccagtattgt gtggttcagc
     6421 cttcaaaaac aaaggtgttc aattgatgct tgatgcggtt atcgactacc ttccaagtcc
     6481 acttgacatc ccagcaatca aaggtattaa cccagataca gacgctgaag aaactcgtcc
     6541 agcatctgac gaagagccat ttgcagctct tgccttcaag atcatgactg acccattcgt
     6601 aggtcgtttg acattcttcc gtgtttactc aggtgttctt caatcaggtt catacgtatt
     6661 gaatacttct aaaggtaaac gtgaacgtat cggacgtatc cttcaaatgc acgctaacag
     6721 ccgtcaagaa atcgacactg tttactcagg tgatatcgct gctgccgttg gtttgaaaga
     6781 tactacaact ggtgactcat tgacagatga aaaatctaaa atcatccttg agtcaatcaa
     6841 cgttccagaa ccagttatcc aattgatggt tgagccaaaa tctaaagctg accaagacaa
     6901 gatgggtatc gcccttcaaa aattggctga agaagatcca acattccgcg ttgaaacaaa
     6961 cgttgaaact ggtgaaacag ttatctcagg tatgggtgaa cttcaccttg acgtccttgt
     7021 tgatcgtatg cgtcgtgagt tcaaagttga agcgaacgta ggtgctcctc aagtatctta
     7081 ccgtgaaaca ttccgcgctt ctactcaagc acgtggattc ttcaaacgtc agtctggtgg
     7141 taaaggtcaa ttcggtgatg tgtggattga atttactcca aacgaagaag gtaaaggatt
     7201 cgaattcgaa aacgcaatcg tcggtggtgt ggttcctcgt gaatttatcc cagcggttga
     7261 aaaaggtttg gtagaatcta tggctaacgg tgttcttgca ggttacccaa tggttgacgt
     7321 taaagctaag ctttatgatg gttcatatca cgatgtcgac tcatctgaaa ctgccttcaa
     7381 gattgcggct tcactttccc ttaaagaagc tgctaaatca gcacaaccag ctatccttga
     7441 accaatgatg cttgtaacaa tcactgttcc agaagaaaac cttggtgatg ttatgggtca
     7501 cgtaactgct cgtcgtggac gtgtagatgg tatggaagca cacggtaaca gccaaatcgt
     7561 tcgtgcttac gttccacttg ctgaaatgtt cggttacgca acagttcttc gttctgcatc
     7621 tcaaggacgt ggtacattca tgatggtatt tgaccactac gaagatgtac ctaagtcagt
     7681 acaagaagaa attattaaga aaaataaagg tgaagactaa tccgtcctca ctctagaagg
     7741 aagtcactta gtggcttcct tttgtcttta gaaaata
//
LOCUS       DAVLHC010000072         7727 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.073, whole genome shotgun sequence.
ACCESSION   DAVLHC010000072 DAVLHC010000000
VERSION     DAVLHC010000072.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 7727)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7727)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7727
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.073"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(<1..366)
                     /locus_tag="VXE25_001948"
     CDS             complement(<1..366)
                     /locus_tag="VXE25_001948"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
                     /protein_id="HEV0772356.1"
                     /translation="MNDEASKQLTDARFKRLVGVQRTTFEEMLAVLKTAYQLKHAKGG
                     RKPKLSLEDLLMATLQYVREYRTYEQIAAVFGIHESNLIRRSQWVEVTLVQSGVTISR
                     TPLSSEDTVMIDATEVKINR"
     gene            complement(459..617)
                     /locus_tag="VXE25_001949"
     CDS             complement(459..617)
                     /locus_tag="VXE25_001949"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931950.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase domain-containing protein"
                     /protein_id="HEV0772357.1"
                     /translation="MSLLETAKRHQLNSEKYLSYLLECLPNEETLVNKEVLEAYLPWT
                     KVVQEKCK"
     gene            complement(688..1117)
                     /locus_tag="VXE25_001950"
                     /pseudo
     CDS             complement(688..1117)
                     /locus_tag="VXE25_001950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014295150.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(1212..1652)
                     /locus_tag="VXE25_001951"
     CDS             complement(1212..1652)
                     /locus_tag="VXE25_001951"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000841825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEV0772358.1"
                     /translation="MKSPIPKAPLAHNFGSASIIAHTIHQKFNLKVPNYRQEEDWARM
                     GLPITRKEISNWHIKASQYYLEPLYNLLRERLLTQPLLHADETSYRVLESDSQLTYYW
                     TFLSGKAEKQGITLYHHDQCRSGSVVQEFLGDYSGYVHCDILRQ"
     gene            1643..1951
                     /locus_tag="VXE25_001952"
                     /pseudo
     CDS             1643..1951
                     /locus_tag="VXE25_001952"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611577.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(2106..2429)
                     /gene="tnpB"
                     /locus_tag="VXE25_001953"
     CDS             complement(2106..2429)
                     /gene="tnpB"
                     /locus_tag="VXE25_001953"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family insertion sequence element accessory
                     protein TnpB"
                     /protein_id="HEV0772359.1"
                     /translation="MTIHLSSLGEVYLVCGKTDMRQGIDSLAYLVKTHFELDPFSGQV
                     FLFCGGRKDRFKVLYWDGQGFWLLYKRFENGRLIWLSTEKDVKALTPEQVDWLMKGFS
                     ITPKI"
     gene            complement(2410..2595)
                     /locus_tag="VXE25_001954"
     CDS             complement(2410..2595)
                     /locus_tag="VXE25_001954"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001136123.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772360.1"
                     /translation="MPQPIVPVEIPQSRRFDSKKRNDILLKIRIGKLEVSFFQSLNLE
                     MVEQLLDKVLLYDNSSI"
     gene            complement(2868..3479)
                     /locus_tag="VXE25_001955"
     CDS             complement(2868..3479)
                     /locus_tag="VXE25_001955"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000251933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit D"
                     /protein_id="HEV0772361.1"
                     /translation="MVRLNVKPTRMELNNLKERLTTAERGHKLLKDKRDELMRRFISL
                     IRENNQLRKEVESYLIDNLKSFAVAKSLKNSQMVEELFSIPSKEIELFVEKENIMSVT
                     VPRMHMNITSQNENSEYSYLSSNSEMDDVFATMNSLIYKLLRLAEVEKTCQLMADEIE
                     KTRRRVNGLEYSIIPNLSETIHYIELKLEEAERANLVRIMKVK"
     gene            complement(3502..4887)
                     /locus_tag="VXE25_001956"
     CDS             complement(3502..4887)
                     /locus_tag="VXE25_001956"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000111247.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit B"
                     /protein_id="HEV0772362.1"
                     /translation="MSVIKEYRTASEVVGPLMIVEQVNNVSYNELVEIQLHNGEIRRG
                     QVLEIHEDKAMVQLFEGSSGINLEKSKIRFAGHALELAVSEDMVGRIFNGMGKPIDGG
                     PDLIPEKYLDIDGQAINPVSRDYPDEFIQTGISSIDHLNTLVRGQKLPVFSGSGLPHN
                     ELAAQIARQATVLNSDENFAVVFAAMGITFEEAEFFMEELRKTGAIDRSVLFMNLAND
                     PAIERIATPRIALTAAEYLAFEKDMHVLVIMTDMTNYCEALREVSAARREVPGRRGYP
                     GYLYTNLSTLYERAGRLVGKKGSVTQIPILTMPEDDITHPIPDLTGYITEGQIILSHE
                     LYNQGYRPPINVLPSLSRLKDKGSGEGKTRGDHAPTMNQLFAAYAQGKKVEELAVVLG
                     ESALSDVDKLYVRFTKRFEEEYINQGFYKNRNIEDTLNLGWELLSILPRTELKRIKDD
                     LLDKYLPLVEV"
     gene            complement(4888..6663)
                     /locus_tag="VXE25_001957"
     CDS             complement(4888..6663)
                     /locus_tag="VXE25_001957"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit A"
                     /protein_id="HEV0772363.1"
                     /translation="MTQGKIIKVSGPLVIASGMQEANIQDICRVGKLGLIGEIIEMRR
                     DQASIQVYEETSGLGPGEPVVTTGEPLSVELGPGLISQMFDGIQRPLDRFKLATHNDF
                     LVRGVEVPSLDRDIKWHFDSTIAIGQKVSTGDILGTVKETEVVNHKIMVPYGVSGEVV
                     SIASGDFTIDEVVYEIKKLDGSFYKGTLMQKWPVRKARPVSKRLIPEEPLITGQRVID
                     AFFPVTKGGAAAVPGPFGAGKTVVQHQVAKFANVDIVIYVGCGERGNEMTDVLNEFPE
                     LIDPNTGQSIMQRTVLIANTSNMPVAAREASIYTGITMAEYFRDMGYSVAIMADSTSR
                     WAEALREMSGRLEEMPGDEGYPAYLGSRIAEYYERAGRSQVLGLPEREGTITAIGAVS
                     PPGGDISEPVTQNTLRIVKVFWGLDAPLAQRRHFPAINWLTSYSLYKDSVGTYIDGKE
                     KTDWNSKITRAMNYLQRESSLEEIVRLVGIDSLSDNERLTMEIAKQIREDYLQQNAFD
                     SVDTFTSFAKQEAMLSNILTFADQANHALELGSYFTEIMEGTVAVRDRMARSKYVSED
                     RLDEIKIISNEITHQIHLILETGGL"
     gene            complement(6726..7046)
                     /locus_tag="VXE25_001958"
     CDS             complement(6726..7046)
                     /locus_tag="VXE25_001958"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000387939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit F"
                     /protein_id="HEV0772364.1"
                     /translation="MEANKYKIGIIGSRDIILPFSMIGFDIFPAYQEQEAINTLRKLA
                     QSDYGVIYITEDIASMILDTIRHYDSQVVPAIILLPTHKQGLNLGLKRIEDNVEKAVG
                     HNIL"
     gene            complement(7036..>7727)
                     /locus_tag="VXE25_001959"
     CDS             complement(7036..>7727)
                     /locus_tag="VXE25_001959"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000380539.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="V-type ATPase subunit"
                     /protein_id="HEV0772365.1"
                     /translation="IKKDFSKLLIPIGIFDIESLKHLVSSLHSDTLPDFMVREVESIW
                     NEYETFNNIRVLDVGADLAYFKHLKLLSNELDEVLSQVIVEMIDFYNIITVKRGLSQN
                     KSHGDILQLLSDEGSISAKEFIYIVENQEIFVWFNKINPSLDSIFSTYELKMQDATIS
                     SSELEFLCDLLLYKTLDQGRYNVEGPLVLARYLLGCEFEVKNLRMIISALQNTIPFES
                     IKERIRPHYGS"
BASE COUNT         2432 a         1604 c         1222 g         2469 t
ORIGIN      
        1 gcgattgatt tttacttccg tcgcatcaat cattaccgtg tcctcagaac tgagaggagt
       61 tcttgaaatc gtaacaccac tttgaacaag agttacttca acccattggc tccgacggat
      121 taagttgctt tcgtgaatac caaaaacagc cgcaatttgt tcataagttc gatattctcg
      181 cacatattga agagtggcca taagaaggtc ttctagactt aatttaggtt ttcgtccacc
      241 ttttgcgtgt ttaagttgat aagctgtttt taatacagct aacatctctt caaaagtcgt
      301 gcgttgaaca ccaacaagac gcttaaatcg tgcatcggtt agttgtttac ttgcttcatc
      361 attcatagaa ctattatacc atattttgtt tcgcaggaag tctattgaaa aatctccaga
      421 ctggagaact cacggatagt tcctaatctg gagatttctt atttgcactt ttcttgtaca
      481 actttagtcc atggtaaata agcctctaaa acctctttgt ttacgagagt ttcctcgttt
      541 ggaagacatt ctagaagata ggatagatat ttctcgctat ttaattgatg acgtttagct
      601 gtttccaaca aactcataat aatagctctt gctttagctc cttcaaaact ttgagaaaat
      661 aaccaccctc gcttttttaa actgagctta ggctaaaaga gtccactgga ctcttttact
      721 ccgtcccata accaatgatt taatggcgcg ttcagctaga ttattggaaa ggaccagatg
      781 tccgtctttc aaaatggtct taaaggtttc ttcatacttg aggctgtatt caattgccct
      841 tcctagtttt gaacctgcta aaactgactg acgccggcac taagcaaaga agtcttccat
      901 taagggctgg agatgttctt gacgtttctg tagtcgttca tcagctggca aagcctccca
      961 gtctctttcc aaggaaaata actgatcaca ataagctaaa cctttagctc ctaaggatga
     1021 tttatctgct tgcttggggg ggcgcttcaa aaaacttcct tctcacatgc gcccaacatc
     1081 caacaagttc agcttcttcc agttgacgat aagcagacga gcggttcgaa gtttaccaag
     1141 cttagcgtcg ccttgctcct aaaccttgga ctgctatcgc ataggcagaa ctagaggact
     1201 aaagtcctaa gttactgccg caaaatatca caatgcacat agccagaata atctcctagg
     1261 aattcttgta ctactgaacc acttcgacac tgatcatggt ggtaaagcgt aatcccttgt
     1321 ttctctgctt tacctgacaa aaaagtccaa tagtaagtca gctgactatc actctctagc
     1381 accctataag aagtttcatc cgcatgaagt aagggctgag tcaatagtct ctctcgcaag
     1441 aggttataaa ggggctccaa atagtattga ctcgccttga tatgccaatt agagatttcc
     1501 ttacgtgtga ttggtaaacc catcctagcc caatcttctt cttggcgata attgggtacc
     1561 ttcagattaa acttctgatg gatggtgtga gcgataatag aagctgagcc aaagttatgc
     1621 gctaaagggg ctttaggaat aggagatttc acaagcttat ccagatgatt atcttttact
     1681 cgttatggac aatgctatat ggcataaatc aagtacctta aagattccga ctaatattgg
     1741 ctttgcattt attcctccat acacaccaga gatgaacccc attgaacaag tgtggaaaga
     1801 gattcgtaaa cgtggattta agaataaagc cttttaaact ttggaagatg tcatgaatca
     1861 actccaagat gttatacaag gactggagaa ggaggtgata aagtccatcg ttaatcggag
     1921 atggactaga atgctttttg aaagcagatg agtataaaaa gaaagtcctc atttcaatag
     1981 aaatcacgac tttctgatgg atttatagta aaatgaaata agaacaggac aaatcgatca
     2041 ggacagtaaa atcgatttct aacaatgttt tagaagcaga ggtgtactat tctagtttca
     2101 atctactata tttttggagt gatagaaaag cccttcataa gccagtctac ttgttctggt
     2161 gtgagagctt tgacatcctt ttctgtactt agccaaatca atctgccgtt ctcaaagcgt
     2221 ttatatagta gccaaaatcc ttgaccatcc cagtaaagga ctttaaagcg gtctttacgt
     2281 ccaccacaaa agagaaagac ttgaccggag aaaggatcca attcaaagtg ggttttaacc
     2341 agataagcca gtgaatcgat tccttgtctc atatcagttt tcccacacac gagatagacc
     2401 tcccctaggc tagatagatg aattgtcata gagcaacacc ttatccaaaa gctgttctac
     2461 catttcgaga ttgagagatt gaaaaaaact tacttcaagc ttgccaatac gaattttaag
     2521 cagaatatca tttctctttt tagaatcaaa acgacgagat tgtggaatct ctacaggaac
     2581 aataggttgt ggcattaaaa tatcctccaa tagttttact ttactaatag tatacaggag
     2641 gagctccatg aatgatagat accttgttat gacgcgctta ctttctatat aattacattt
     2701 acgatttact aatcctaaat ctagattagt agaaacattt tcattatcta acaaaccaaa
     2761 attttgaaaa agatatcctg atactgtcaa taaaaaaagc ttagaaaggc ttaaagcctt
     2821 atccaagctg atatttgttc atctaattaa taatctaaat aaaggatcta cttcactttc
     2881 ataatacgaa ctaaattggc tctttctgcc tcctctagtt tcaattctat ataatgaata
     2941 gtttccgaca agtttggaat aatcgagtat tctaaaccat ttacacgtct acgtgttttt
     3001 tctatttcat cagccattaa ctgacacgtt ttttcaactt ctgccagtct tagtaattta
     3061 taaattaaac tattcattgt agcaaataca tcatccattt cactattaga agataaatag
     3121 ctgtattcac tgttctcatt ttgagaagta atattcatat gcattctagg aactgttaca
     3181 ctcatgatat tttctttctc aacaaataat tcaatttctt tcgatggaat tgaaaataat
     3241 tcctccacca tttgagaatt ctttaatgat ttagcaactg caaaggattt tagattatca
     3301 attagataac tttccacttc tttccgaagt tgattattct cacgaatcaa agaaataaat
     3361 cgcctcatca attcatctct tttatccttt aataacttat gtccacgttc agctgttgtc
     3421 aaacgttcct ttaagttatt caattccata cgagttggtt ttacattcaa acgtaccata
     3481 gataatcact ccatttccgg attaaacttc taccaaaggt aagtatttat caagcaaatc
     3541 atctttgata cgttttaact ctgttctagg aagaattgat agtaattccc acccaagatt
     3601 caacgtatct tctatatttc gatttttata aaatccttgg tttatgtact cttcttcaaa
     3661 acgctttgta aacctcacat acaatttatc tacatcagat aaagccgatt ctcctaatac
     3721 tactgctaac tcttcaacct ttttcccttg ggcataggct gcaaacagtt gattcatagt
     3781 tggagcatga tctccacgag ttttaccttc tccagatccc ttatctttta atcgagagag
     3841 agaaggtaaa acattgattg gtggacgata accttgatta tacaactcat gcgacaaaat
     3901 aatttgccct tcagtaatgt atccagttaa atcaggaatt ggatgtgtta tgtcatcttc
     3961 tggcattgtt aaaataggaa tctgtgtcac cgaacctttt ttaccaacta agcgaccagc
     4021 cctttcgtat agagttgata aatttgtata taaatatccc ggatagcctc gtctccctgg
     4081 aacttcacgg cgagctgccg agacttcacg taacgcttca caatagttag tcatatccgt
     4141 catgataact agaacgtgca tatctttttc aaaagctaga tactctgccg cagttaaagc
     4201 aatgcgggga gttgcaatac gctcaattgc aggatcattt gccaagttca taaataaaac
     4261 cgaacgatcg atcgctcctg tttttctgag ttcttccata aaaaactcag cttcttcaaa
     4321 agtaataccc attgctgcaa atacaaccgc aaaattttca tcagaattta aaacagtcgc
     4381 ttgtcttgct atctgagcag ctaattcatt atgaggtaag cccgaacctg aaaatactgg
     4441 taatttttga ccacgtacaa gagtattcaa atgatcaata gaggagatcc ctgtctgaat
     4501 aaattcatct ggataatctc tagatacagg attaatagct tgaccatcaa tatctaaata
     4561 tttctctgga attaaatctg gtccaccatc aattggtttt cccatcccat taaaaatacg
     4621 accaaccata tcctcagata cagccaattc taatgcatga ccagcaaaac gaattttaga
     4681 cttttctaaa tttattccac tagatccttc aaaaagctga accattgctt tatcttcgtg
     4741 gatctctaaa acttgtccac gacgaatttc tccattatga agttgaattt caactaactc
     4801 attgtaagac acattattta cttgttcaac aatcataaga ggcccaacaa cttcactagc
     4861 agttctgtat tcttttataa cactcattta tagacctcct gtttctaata tcaaatgaat
     4921 ttgatgtgta atctcatttg atataatttt gatttcatct aatctatctt ctgaaacata
     4981 tttacttctc gccatacggt ctcgaactgc cacggtacct tccataatct ctgtaaagta
     5041 agaacccaac tctaaagcat gatttgcctg atcagcaaaa gtgagaatat tacttagcat
     5101 tgcttcttgt tttgcaaacg aagtgaatgt atctaccgaa tcaaaagcgt tctgttgcaa
     5161 ataatcttct cgaatttgtt tagcaatttc catcgttagt cgttcattat cagacagaga
     5221 atcaattcca acaagacgaa caatttcctc taaactagat tcccgttgta agtagttcat
     5281 cgcacgagtt attttactat tccaatctgt cttctcttta ccatctatat aagtgcccac
     5341 actgtcttta tatagtgaat aagatgtaag ccagttaatt gcaggaaaat gacgtcgctg
     5401 tgccaacgga gcatcaagcc cccaaaaaac tttcacaatc cgtaaagtgt tttgagtaac
     5461 tggttctgaa atatctccac caggtggcga tacagctcca atagcagtaa tcgttccttc
     5521 acgttctgga agccctagaa cctgagaacg tcctgctctt tcataatatt cagcgatacg
     5581 acttcccaga taagcaggat aaccctcatc accaggcatt tcttctagac gtcctgacat
     5641 ttcacgtagc gcttctgccc aacgtgaagt tgaatcagcc ataatggcga cagagtagcc
     5701 catatcacga aaatactcag ccatggtaat tcctgtataa attgaagcct cacgagcagc
     5761 aacaggcata tttgaagtat tagcaatcag aactgtccgt tgcataattg attgtccggt
     5821 attagggtca atcaactcag gaaactcatt cagtacatcc gtcatttcat ttccacgttc
     5881 tccacaaccg acataaataa caatatcaac attggcaaat ttagctactt ggtgttgtac
     5941 aactgtcttt cctgctccaa acggtccagg aactgctgca gctccccctt tggttactgg
     6001 aaagaatgca tcaataactc gttgacctgt gattaatggt tcttctggaa ttaaacgttt
     6061 agaaacagga cgcgccttgc ggacaggcca tttttgcata agcgttcctt tatagaaact
     6121 accgtccaat ttttttattt catatacaac ttcatcaatt gtaaaatcgc cagatgcaat
     6181 agaaacgact tctccagata ctccataagg aaccataatt ttatgattaa ctacctcggt
     6241 ttccttgaca gttccaagaa tatcacccgt actcactttt tgaccaattg ctatagtgga
     6301 atcaaaatgc cacttaatat ctctatccaa acttggaact tctaccccac gaactagaaa
     6361 atcattatga gtagccaatt taaatcgatc taatgggcgt tgtatgccat caaacatttg
     6421 agaaatcaat cctggcccta attcaaccga gagaggttct ccagttgtaa caacaggttc
     6481 tcccggacca agaccagatg tttcttcata gacttggata gatgcctgat ctcttctcat
     6541 ttcaataatt tcaccgatta accctagctt acctacacgg caaatatctt gaatattagc
     6601 ctcctgcata cctgatgcaa taactagagg tcccgatact tttataatct tcccttgagt
     6661 caaagttatt ctccttacta agtccaaaaa ttatagaata atattacaga caattttgta
     6721 cattattata aaatattgtg tcctactgct ttctctacat tatcctctat acgttttaat
     6781 cctaaattta aaccttgttt atgagtcggt aataaaataa tagcaggcac aacttgggaa
     6841 tcataatggc gaattgtatc taatatcatt gaagcaatgt cttcagtgat ataaatgaca
     6901 ccataatcag attgagctaa ttttcttagt gtatttatag cttcttgttc ttggtaggca
     6961 ggaaatatat caaacccaat catgctaaat ggtaaaataa tatcacggct accaattatg
     7021 ccaattttat acttattagc ttccataatg tgggcgtatc ctttctttta ttgattcaaa
     7081 gggaattgta ttttgaagag ctgatatgat cattctgaga ttctttactt caaactcaca
     7141 tcccaataaa tatctagcaa gaactaacgg cccctctaca ttgtaccttc cttgatctaa
     7201 agttttatac aatagtaaat cacataaaaa ttctaactca gaagatgaaa ttgttgcgtc
     7261 ctgcatcttc aattcataag ttgaaaagat tgaatctaag cttggattta ttttattgaa
     7321 ccacacaaat atttcttgat tttctacaat gtatataaat tctttagcag aaatacttcc
     7381 ttcatctgaa agtaattgta aaatatcccc atgactctta ttttgagata aaccacgttt
     7441 tacagtaata atattataaa agtcaatcat ttcgacaata acctgagaca gtacctcatc
     7501 taactcatta gataaaagtt tcagatgttt aaaatatgct agatcagctc cgacatcaag
     7561 tacacgaata ttattaaaag tttcatactc attccaaatt gattctactt cacgaaccat
     7621 aaaatcagga agtgtatctg aatgtaagga agaaactaaa tgttttaaac tttctatatc
     7681 aaaaatccct attggaatta ataatttaga aaaatctttc ttaattg
//
LOCUS       DAVLHC010000073         7503 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.074, whole genome shotgun sequence.
ACCESSION   DAVLHC010000073 DAVLHC010000000
VERSION     DAVLHC010000073.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 7503)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7503)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7503
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.074"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(1..324)
                     /locus_tag="VXE25_001960"
                     /pseudo
     CDS             complement(1..324)
                     /locus_tag="VXE25_001960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="internal stop; incomplete; missing C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            383..565
                     /locus_tag="VXE25_001961"
     CDS             383..565
                     /locus_tag="VXE25_001961"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000842022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase"
                     /protein_id="HEV0772366.1"
                     /translation="MKSQKIKVSFTQSKIVTPILLVNKTIVWYGAMPLLGKVDEMTIL
                     RLESASIASELVAGLR"
     gene            896..1849
                     /locus_tag="VXE25_001962"
     CDS             896..1849
                     /locus_tag="VXE25_001962"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001155321.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS30-like element ISSpn8 family transposase"
                     /protein_id="HEV0772367.1"
                     /translation="MQEHYTPKGKHLTIDNRRLIERWKNENKSNREIAGLLGKAPQTI
                     HNEVKRGTTLQQVRKGLYKKVYSADYAQTVYQFNRKRSVKKLILTKEIREKILHYHKQ
                     KFSPEMMVNKKQVKVGISTIYYWFHNGHLGLTKADMLYPRKRKGVKKQASSNFKPAGK
                     SIEERPDVINLRLENGHYEIDTVLLTKIKNYCLLVLTDRRSRHQIIRLIPNKTAESVN
                     QALTLLLGEHRILSITADNGSEFKRLSEVFPEEHIYYAHAYSSWERGSNENHNRLIRR
                     WLPKGTKKTTPKEVAFIENWINNYPKKCLDYKSPSEFLLGG"
     gene            2170..2304
                     /locus_tag="VXE25_001963"
                     /pseudo
     CDS             2170..2304
                     /locus_tag="VXE25_001963"
                     /inference="COORDINATES: protein motif:HMM:NF012870.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
     gene            complement(2542..3961)
                     /locus_tag="VXE25_001964"
                     /pseudo
     CDS             complement(2542..3961)
                     /locus_tag="VXE25_001964"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886556.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(4217..6067)
                     /locus_tag="VXE25_001965"
                     /pseudo
     CDS             complement(4217..6067)
                     /locus_tag="VXE25_001965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000261804.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
     gene            complement(6054..6419)
                     /locus_tag="VXE25_001966"
     CDS             complement(6054..6419)
                     /locus_tag="VXE25_001966"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000263054.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family plasmid mobilization relaxosome
                     protein"
                     /protein_id="HEV0772368.1"
                     /translation="MVYRYRTNLKKVFLTDSELHQLNERIDKSHCQNFSVYARKVLLN
                     PNMSFVTINTDTYDQLVFELRRIGNNINQIARAINQSRLISQEQLQELSKGVGELIKE
                     VDKEFQVEVKRLKEFHGSY"
     gene            complement(6429..6788)
                     /locus_tag="VXE25_001967"
     CDS             complement(6429..6788)
                     /locus_tag="VXE25_001967"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018379612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772369.1"
                     /translation="MSEQYRDIRKEVNLTADELKQIEKMMEVDNYRHFSSFVRDKILM
                     TDDKQLAAKEWFSLWQSQKFEQISRDVHLVLIIARENHQVTQEHVSILLTCVQELIAE
                     VNQVQSLSRGFREKYMR"
     gene            complement(7224..7496)
                     /locus_tag="VXE25_001968"
     CDS             complement(7224..7496)
                     /locus_tag="VXE25_001968"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000754878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772370.1"
                     /translation="MKKVDGYRLLNKPDHAVLLFPLTVIIFVLLGACFFKPHFHNSFR
                     GYYSKIDCGIAIQSTGLQIYGDTVFVDGAIYELNEVTMQILDNEKT"
BASE COUNT         2323 a         1414 c         1266 g         2500 t
ORIGIN      
        1 ctcaacaata gtatacccgt ttttcctgta ttgtgctagc cagttaagaa gtatcgtacg
       61 acttgggaga ccgtattcaa gagaaactct atctttagtc cagccttcat gtcagacttt
      121 atgaatcatt tcttgtttta aatcaggaga atagtaacga ttttttcctt ttttgacgaa
      181 ctctattccg taacgatcaa tcaatttaat catgtaccta agattagaat tgtttatccc
      241 aaatttattt gaaagcttct ctaagctata tccttgtttt ctaagttcat agatctgaac
      301 tttatcatca taagttagtt tcataataaa acaccccaaa agttagattt tttctgtcta
      361 acttttgggg tgtagttcac agttgaagag ccagaaaatt aaagtgtctt ttactcaatc
      421 aaaaatagta acgcctattc ttttggtgaa taagactatt gtttggtatg gtgcaatgcc
      481 attattaggg aaggtagatg agatgaccat attacgtttg gaatcagcta gtatagcttc
      541 tgaactagtg gcaggtttac gatagagaaa atttttaaaa atttctatgt atgattttca
      601 tttctttagt gagactgttg ccattatcac attcgatgaa agttctataa tgaagttagc
      661 caccttacct tagtcaagaa ttagatgttt cactatgttt gagtaagttg atgatttcat
      721 ttgataacag gtttgaaact gttaggctag gtgcccaagg ctaatcatag ccttggttta
      781 gctgaaaaaa caggttcaag ggttcctgtt gtcaaatgaa atgtgattta aggtataaga
      841 aaacacctct gtgctatact tgttgttcac cacaaacaca aggaaaggca cagagatgca
      901 agaacattat accccaaaag ggaaacattt gacaatagat aaccgtcgct tgattgagcg
      961 gtggaagaat gaaaataagt ccaatcgtga aattgcaggc ttgttaggaa aggcgcctca
     1021 aacgattcat aatgaagtca aaagaggtac aactttacaa caagtgagaa aagggctata
     1081 caaaaaggtc tattctgccg attacgcaca aactgtttac caattcaatc gaaaacggtc
     1141 ggtgaaaaag ttaattttaa caaaggaaat cagagagaag atcttacact atcataagca
     1201 aaaattttcg cctgaaatga tggttaacaa gaagcaagtg aaagttggta tttcaaccat
     1261 ctactactgg tttcataatg gtcatttagg attgacgaag gccgacatgc tttatcccag
     1321 aaaaaggaaa ggtgtcaaga agcaagctag ttcgaacttt aagccggcag gtaaatctat
     1381 cgaagaacgt cctgacgtta ttaatcttcg cttggaaaat ggtcattatg aaattgatac
     1441 cgtcctactg actaagataa aaaattattg cctgttagtc ttaaccgacc ggcggagcag
     1501 acaccaaatt ataaggttaa ttccaaataa aactgctgaa tctgtcaatc aggcgcttac
     1561 gttactatta ggggagcatc gtattctgtc cattactgca gataatggtt cggagttcaa
     1621 acgattgtct gaggtatttc ctgaggaaca tatctactac gcacatgctt actcttcatg
     1681 ggagagaggt tcaaatgaaa atcataatcg attaattcgg agatggttac ctaaaggaac
     1741 caagaaaacg actccgaaag aagtagcttt tatcgaaaat tggattaaca actaccctaa
     1801 aaaatgcttg gactacaagt cgccaagtga atttcttttg ggtggctaac ttcaacttga
     1861 aatttgggct ttgtctctat gctaaaggaa tccgctataa atacaagtac tatagccgtc
     1921 ggcattcctc attaacacga cccaatttga ttaatcagtg ttttcaaaca aaaggtaaaa
     1981 atgaaatctg gctgggggat ttaacttata ttccgacaaa agcaggtact ctttatttat
     2041 cattatatat atgtttatag cagaaaaatt gttggttagg caatgggaaa tcgaatgcaa
     2101 gataagttgg taacgaatgt tttcaatcaa gcttatcata gagaaaatct caaataagaa
     2161 ctagtcggcc ataccgatca aggatctcaa tatactggag ctagatttca agaactcctt
     2221 aaacagaaaa gatgcaagtc tagcctgagt cgaaaaggca atccatatga taatgcaccc
     2281 atggaatcct tttacaaaac ataaaaagag aacttgtcaa tgatgccaat ttcgcaacta
     2341 ttgaacgaaa tctttaaata tattgaaatc tattacaatc ctaaatatct ccattcggca
     2401 ttagggtacc aataactaat agagtttgaa aaaaatagtc actaatcatc gagtccactg
     2461 aaaaagtaag ctctacagtt caactaaaat gaaaaaagag ggatctatct cctgcttgga
     2521 tagattcctc tttgcttttc cttatttttg gtttattaga gttataatcc tcttcatatt
     2581 aaccacaaat atggttgtgg cggcttgtaa ctccatgttt aaaagacctg gtgctctagc
     2641 tacattaaga ccatgtctgt tttcaagttc cgcatttttg gcttctatct tgtagcgatg
     2701 tttggccttt tctttaaaat agggcgcttc ctgaaacctc ttctggaaaa tatgttcatc
     2761 gctcttaagg ggtatcaaat aagtcttaga cttagcccct tctttataac agcccatatt
     2821 tgacagtgct tgatgtcaaa atagtgggtt tcctgagccg tccttcttcc tgtcttttcc
     2881 ttctttagtg ccatatgccc ttctggacaa acaaagagac ctgcgtcctt gttatagaaa
     2941 aactcatctt ccttcctacg aaagcctttt gaaatagttg gatatggcct agcgactcaa
     3001 tgcacacgtt ctttcttggt aaattgcata ttatccttcc cagagtaggc cctatctcca
     3061 acaatagctt caatcgtcac gccattatcc ttagatttgt gatagagttc ttctaaaaca
     3121 ggaccatcac ttttttcacc cgatgtcacc acacaggcag taataatccg ttcatcggtc
     3181 atggcaaaat gctctttgta cccgtaaaag gaactatcgg ctgacttatg tccaattctt
     3241 gcttcttctt tgacagagga ttccaagtgc tctaagtcat cctctacagc ttctttaagg
     3301 taattgaatt ttgtgagata gctggtattc cagtcaattc gtcatgcttc tcaaggactg
     3361 atattaattc ttgtgtatat cttaattcag ctactagagt atcttcctga ggcttactag
     3421 gaaattctgc cttgatatat tccgaatact gataaatcgt tttacgcaag gcttttgagc
     3481 gttctcggag gacttcttga ggtttcttgt gattgtaatg aactttggta tgagtcgcat
     3541 ccacaatgag aatgttactt ttaatcagac cgagctctat cgcaatctga acagatttag
     3601 cgatgagcaa atcaagtaat cgttcatctt tgttccgaag ttttcggaat ttagtcaatg
     3661 aggacggttc aataacagga gctagaccaa ggaagtattt gaaggtcata ccagaaaagg
     3721 agcgctccac cacatccaca tcggacaact tatagatgtc ttttaataag agatacttga
     3781 acatcatgat aaggagagag taggaacgac atccgaagtc aggttgataa ttcttttcca
     3841 gctcgtcata aataaaacta aaatcacaga gttccattag ctgtcgtaaa aaatgagttt
     3901 tgggaacaac aatatcacac agagtagaat agggactaac atcgattatc aagcatacca
     3961 tcacctcatc tttagtatac catcatacga tgactttttc agtggactcc gaattatctt
     4021 aactcttgac aagtccagtg atgcaatgat agagcataga caactttaat gatttggggt
     4081 cgaagcgtaa tcgtaaaata ggtaaaatcg tctttgaatg catttttatt aatgtttgtt
     4141 ttagaagtta aaccgatatt ggcaaccata aacagaaaag atatccaaaa aaatttgagt
     4201 ttgtcttcag tctgatttat atttcattca taatttcttt attgatacac tcatcaaaaa
     4261 ccttaaataa ttgtccaagc tttcttattg ttttctcata ctcatcaaga acattaccaa
     4321 attcctgttg taacttcaaa agttcttcat tgacttgttc taaagttgtt gattctgtca
     4381 tgttcaattt agaaaattca tgcctagcta gtttttggct acccgaacct tcactcttag
     4441 aattgataag tacttccgcc atcttattta aggtggcaat tttttcattt gtttgagtca
     4501 gttttatatc tagctctgct atttcggaaa ccaagttgtc tttaatgtct tggtatttct
     4561 tatctgtctc agttaactca atcaagaggc taatctcaga aatcttttct tgaagtcttt
     4621 caacagtcgg tcttctgtat ggtattactc gactatcgtt ggttagctgc ctaatcaagg
     4681 ttctcccttt gatatactga ttcttatccg aatgttcttt gttatagaca aaatatgagg
     4741 ttgtctcacg aatgtagact ttatattttt tctgattttc ttcttccata atatccagtt
     4801 gatagttagg aatgaaaata agaccactct gatttatacc aaaggacact ttgatataaa
     4861 tcccctcatc aactaacttc tcaatttggt gttctgtaag ttttacttca aattcatgaa
     4921 cggcatctcg tttttcctta aatgtctcaa aggcttcctc aatttcttca gtagatacct
     4981 tctccttatc tcgttcttct tgaaaagcac ggtactgtgc ctgtagattt tctattcctt
     5041 ctgaaacacc tacttcctta tttttaaaat aatcttgaaa aaaattgaca tcatataatt
     5101 tctcatcact tattttttta tgactcagac tgaattgctt tccattttct tcaagtataa
     5161 agattacatt tttttgtttt aagtcaatgg ttagattcaa ttcttttgat tttgttagta
     5221 acccttctaa agaattgaca cagttcaaca aaaattctaa acgacttgca atctcttgct
     5281 tggcaaaatg cattctaaaa aaatcttcat catataaatc tcgtttactg agttgacgtc
     5341 ctcgaattgg ttttgtcatt gcccgatccg tcatcatgaa tcgactatgc ttctgactaa
     5401 aatcaatctg aacatgcaac tgctttgctt tctctaaaaa atcatcaaac tatttagatt
     5461 gctgcatcaa aaaataaaga cgttgtttca attcaaactt atgactagat tccctatatt
     5521 ttttataacc tcgataagaa taacgtttct caataatttt tgcaccagcc attttagaaa
     5581 tacggtctga aatcatacgg aggtttcgtt ccaaggcata gttccatatc aactttttat
     5641 ctgaattgcg gtcaatagcg ttgattagga tgtgattatg aacatgatct ttgtctgtgt
     5701 gagttgctac gataaactta aaacgacctc ctgtcaattc catcatggtc tcataaccaa
     5761 tgcggttaat ttcttcaggt gtcagattat cttcaggaga aaatgattgg atgagatgat
     5821 gggcatgaat agtttgttgg tgtttttctt gtcggtcatt tctggactcg tacaacttgt
     5881 cgttattagt aaagttaaca ttgtacattt ctaccatttc tgtatggcta ggaaaatcta
     5941 agtaattact catgccaaaa tcagatacta attttagatt atctgtttta tctggattga
     6001 ggatatattt aatcaaacgc ctacgatatt tttttccgtg cgtcgcaaag tgtttagtaa
     6061 ctaccatgaa actccttcag tcttttcacc tccacttgaa attctttgtc cacttcctta
     6121 attaactctc cgactccttt actcaattct tgtaactgtt cctgagaaat cagacggctt
     6181 tgattgatag cacgcgcaat ttgattaatg ttatttccga tccgtctcaa ttcaaatact
     6241 aactggtcat aggtatccgt attaatggtg acaaatgaca tattgggatt cagcaacact
     6301 ttcctggcat agactgaaaa attttgacag tgactcttat cgattcgctc attcaattga
     6361 tgtaattctg aatctgttag aaatactttt ttgagattgg tacgataacg ataaaccata
     6421 gtagcctcct atctcatgta tttttcacga aacccacgac tgagtgactg tacttgattg
     6481 acttccgcaa tcaattcttg aacgcaggtc aataagattg acacgtgttc ttgagtcact
     6541 tggtgattct ctcttgcgat aatcaaaacc aaatgcacat ctcgactgat ctgttcaaac
     6601 ttttgagact gccaaaggga aaaccattct ttggcagcta actgtttgtc atcagtcatc
     6661 aaaattttat ccctgacgaa tgatgaaaag tgacgataat tatcaacctc catcattttt
     6721 tcaatctgtt ttagctcatc tgcggttaga tttacctctt ttcgaatgtc acggtactgt
     6781 tcagacatct cttttcctca ctttcatcct ttctcggata aaccccgacc ccgtgtgtca
     6841 tacgggaaat ttcttaaagt ccttgttcgg tctttgcgag ctcaggcatt gtggtcacaa
     6901 tacccaaaaa atcatatcgc cagctaacca aaaccttcca gttttgacag ctaaccataa
     6961 gataacttgg tggcttcgcc cccaaacccc cagtgaaaaa ttgaggtttt attttcttag
     7021 gaatgatatt aggacaacag ggatgatttg gaaaaggtat cacattattg aaaggaaggt
     7081 aagaaaaaag agagcaaaag ctctcataac aatccattta aatactacag agtagttaaa
     7141 aattagtaac taatatttta tataataaga atctttctct gtcttatttt ttataacaat
     7201 acctttttta tcaaatgtac ctatcacgtt ttttcgttat ctaatatctg cattgtaact
     7261 tcattcaatt catatattgc tccgtctaca aaaactgtat caccataaat ttgtagtccg
     7321 gtcgactgaa ttgcgatacc acagtctatt ttactgtaat aacctctaaa actattatga
     7381 aaatgtggct taaaaaaaca agcacctaat aaaacaaata taattaccgt taaaggaaaa
     7441 agtaatacag catgatcagg cttatttagt agtctatatc catcaacttt tttcatagta
     7501 gga
//
LOCUS       DAVLHC010000074         7154 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.075, whole genome shotgun sequence.
ACCESSION   DAVLHC010000074 DAVLHC010000000
VERSION     DAVLHC010000074.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 7154)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7154)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7154
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.075"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(<1..900)
                     /gene="phtA"
                     /locus_tag="VXE25_001969"
     CDS             complement(<1..900)
                     /gene="phtA"
                     /locus_tag="VXE25_001969"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal histidine triad protein PhtA"
                     /protein_id="HEV0772371.1"
                     /translation="MKINKKYLVGSAAALILSVCSYELGLYQARTVKENNRVSYIDGK
                     QATQKTENLTPDEVSKREGINAEQIVIKITDQGYVTSHGDHYHYYNGKVPYDAIFSEE
                     LLMKDPNYKLKDEDIVNEVKGGYVIKVDGKYYVYLKDAAHADNVRTKEEINRQKQEHS
                     QYREGGTPRNDGAVALARSQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKN
                     ELSASELAAAEAFLSGRGNLSNSRTYRRQNSDNTSRTNWVPSVSNPGTTNTNTSNNSN
                     TNSQASQSNDIDSLLKQLYKLPLS"
     gene            complement(1154..2887)
                     /gene="ptsP"
                     /locus_tag="VXE25_001970"
     CDS             complement(1154..2887)
                     /gene="ptsP"
                     /locus_tag="VXE25_001970"
                     /EC_number="2.7.3.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoenolpyruvate--protein phosphotransferase"
                     /protein_id="HEV0772372.1"
                     /translation="MTEMLKGIAASDGVAVAKAYLLVQPDLSFETITVEDTNAEEARL
                     DAALQASQDELSVIREKAVGTLGEEAAQVFDAHLMVLADPEMISQIKETIRAKKVNAE
                     AGLKEVTDMFITIFEGMEDNPYMQERAADIRDVTKRVLANLLGKKLPNPASINEEVIV
                     IAHDLTPSDTAQLDKNFVKAFVTNIGGRTSHSAIMARTLEIAAVLGTNNITEIVKDGD
                     ILAVNGITGEVIINPTDEQAAEFKAAGEAYAKQKAEWALLKDAQTVTADGKHFELAAN
                     IGTPKDVEGVNNNGAEAVGLYRTEFLYMDSQDFPTEDEQYEAYKAVLEGMNGKPVVVR
                     TMDIGGDKELPYFDMPHEMNPFLGFRALRISISETGDAMFRTQIRALLRASVHGQLRI
                     MFPMVALLKEFRAAKAVFDEEKANLLAEGVAVADNIQVGIMIEIPAAAMLADQFAKEV
                     DFFSIGTNDLIQYTMAADRMNEQVSYLYQPYNPSILRLINNVIKAAHAEGKWAGMCGE
                     MAGDQQAVPLLVGMGLDEFSMSATSVLRTRSLMKKLDTAKMEEYANRALTECSTMEEV
                     LELQKEYVNFD"
     gene            complement(2893..3156)
                     /locus_tag="VXE25_001971"
     CDS             complement(2893..3156)
                     /locus_tag="VXE25_001971"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019775469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphocarrier protein HPr"
                     /protein_id="HEV0772373.1"
                     /translation="MASKDFHVVAETGIHARPATLLVQTASKFASDITLEYKGKSVNL
                     KSIMGVMSLGVGQGADVTISAEGADADDAIAAISETMEKEGLA"
     gene            3507..3725
                     /gene="nrdH"
                     /locus_tag="VXE25_001972"
     CDS             3507..3725
                     /gene="nrdH"
                     /locus_tag="VXE25_001972"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000259243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutaredoxin-like protein NrdH"
                     /protein_id="HEV0772374.1"
                     /translation="MVTVYSKNNCVQCKMTKRFLDSNNVSYREINLDEQPEYVDQVKE
                     LGFSAAPVIQTPTEVFSGFQPGKLKQLA"
     gene            3806..5965
                     /gene="nrdE"
                     /locus_tag="VXE25_001973"
     CDS             3806..5965
                     /gene="nrdE"
                     /locus_tag="VXE25_001973"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000523276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class 1b ribonucleoside-diphosphate reductase
                     subunit alpha"
                     /protein_id="HEV0772375.1"
                     /translation="MGLKHLEDVTYFRLNNEINRPVNGQIMLHKDKEALDAFFKENVV
                     PNTMVFDSIKDKINYLIEHNYIETAFIKKYRPEFLEELAQFIKDQNFQFKSFMAAYKF
                     YNQYALKTNDGEYYLENMEDRVFFNALYFADGNEAVAIDIANEIIHQRYQPATPSFLN
                     AGRARRGELVSCFLIQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGY
                     EGAASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIIAFLSTKKENADEKVR
                     VKTLSLGVVVPDKFYELARKNEEMYLFSPYSVEKEYGVPFNYIDITEKYDELVANPNI
                     RKTKIKARDLETEISKLQQESGYPYVVNIDTANRANPVDGKIIMSNLCSEILQVQEPS
                     LINDAQEFLQMGTDVSCNLGSTNVVNMMTSPDFGRSIRAMVRALTFVTDSSHIVAVPT
                     IDHGNSQAHTFGLGAMGLHSYLAQQLIEYGSPESVEFTSIYFMLMNYWTLVESNNIAR
                     ERGITFHNFEKSDYANGSYFDKYVTGEFVPTSDRVKELFKNVFIPGVADWAELRDKVQ
                     EDGLYHQNRLAVAPNGSISYINDVSASIHPITQRIEERQEKKIGKIYYPAAGLSTETI
                     PYYTSAYDMDMRKVIDVYAAATEHVDQGLSLTLFMRSDIPKGLYEWKRENKQTTRDLS
                     ILRNYAFNKGIKSIYYVRTFTDDGGEVGANQCESCVI"
     gene            6153..7115
                     /gene="nrdF"
                     /locus_tag="VXE25_001974"
     CDS             6153..7115
                     /gene="nrdF"
                     /locus_tag="VXE25_001974"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004253599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class 1b ribonucleoside-diphosphate reductase
                     subunit beta"
                     /protein_id="HEV0772376.1"
                     /translation="METYYKAINWNAIEDVIDKSTWEKLTEQFWLDTRIPLSNDLDDW
                     RKLSNKEKDLVGKVFGGLTLLDTMQSETGVQALRADIRTPHEEAVFNNIQFMESVHAK
                     SYSSIFSTLNTKAEIEEIFEWTNTNPYLQKKAEIVNEIYLNGSPLEKKVASVFLETFL
                     FYSGFFTPLYYLGNNKLANVAEIIKLIIRDESVHGTYIGYKFQLGFNELPEEEQEKLK
                     EWMYDLLYTLYENEEGYTESLYDGVGWTEEVKTFLRYNANKALMNMGQDPLFPDSAED
                     VNPIVMNGISTGTSNHDFFSQVGNGYLLGEVEAMQDDDYNCGLD"
BASE COUNT         2077 a         1534 c         1333 g         2210 t
ORIGIN      
        1 actcaaaggc agtttgtaga gctgtttcaa gagactatca atgtcattac tttgacttgc
       61 ttgactgtta gtgttgctgt tgttgcttgt gttagtattt gtagttcctg gattgcttac
      121 agaaggtacc cagtttgttc ttgaagtgtt atcgctattt tgtcggcgat aggttcttga
      181 atttgacaga tttccccgac cagataggaa ggcttctgca gcagctaact cgctagctga
      241 taactcattc ttaggaatgt aatggtaatg gtcgccgtga ggaacgatat aagcatcacc
      301 agtatcctct atgatatcag aagcattaaa gatataacca tcatctgtag tatagcgtcc
      361 ttgcgaacgt gccaaggcaa cagctccatc gtttcttgga gtccctcctt cacgatactg
      421 actatgttct tgtttttgtc gattgatttc ctcttttgta cggacgttat ccgcgtgggc
      481 agcatcctta aggtaaacat agtattttcc atctaccttg ataacatatc cacccttgac
      541 ctcattaaca atatcctcat cttttagctt atagtttgga tctttcatga gtaattcttc
      601 actgaaaatc gcatcataag gaaccttacc attgtaataa tgatagtggt cgccatgtga
      661 agtgacatag ccttggtctg ttatcttgat gacgatttgc tcagcattga ttccttcacg
      721 cttgctaacc tcatcaggag tcaaattctc cgttttttgc gtcgcttgtt ttccatctat
      781 ataggaaaca cgattatttt ccttaaccgt tctagcttga tacagtccca actcgtaaga
      841 acaaacactt aaaatcaaag ctgccgcaga accaacaagg tatttcttat taattttcat
      901 cgaaactctc tttctatttg atatttctag ttgcaattca tttctaaatt gcagaaactc
      961 ctctctatta cttaactggt taatagttta ctcctaaatc tccaacttgt caagaatttt
     1021 atgaaccatt taagtatttt ttgttctgac cactactttt tcaaggttgg actttctata
     1081 aaaaagattt tcttgaaaat tctttttaaa atatcaaaaa aatccctgta actgagttgc
     1141 agggacttgt cgattaatca aaattaacgt attctttttg aagttcaaga acttcttcca
     1201 ttgttgagca ttctgtaagg gcacggtttg cgtactcttc catcttagct gtgtcgagtt
     1261 tcttcatcaa gctgcgtgta cgaagtacag atgttgctga catagagaac tcatccaagc
     1321 ccattccgac aagaagtgga acagcttgtt ggtcaccagc catctcacca cacataccag
     1381 cccatttacc ttcagcgtga gctgctttga tcacattgtt aatcaagcgt aggattgatg
     1441 ggttgtatgg ttggtaaagg tatgaaactt gttcgttcat acggtctgct gccattgtat
     1501 attggatcaa gtcgtttgta ccaattgaga agaagtcaac ttctttagca aattggtctg
     1561 caagcatagc cgctgcagga atctcaatca tgataccaac ttggatgtta tccgcaactg
     1621 caacaccttc agcaagaagg tttgcttttt cttcatcaaa gactgctttc gctgcacgga
     1681 attctttcaa gagcgcaacc attgggaaca tgatacgcaa ttgaccgtga acagacgcac
     1741 gaagaagagc acggatttgt gtgcggaaca tagcatctcc agtctcagag atagagatac
     1801 gaagagcacg gaatccaagg aatgggttca tttcgtgagg catatcgaag taaggaagtt
     1861 ccttatctcc accgatatcc attgtacgaa cgacaacagg tttaccgttc attccttcaa
     1921 gaacagcctt gtatgcttca tactgctcat cttcagttgg gaagtcttga gaatccatgt
     1981 acaagaactc tgtacggtaa agtccaacag cttctgcacc gttgttgtta acaccttcaa
     2041 cgtcttttgg agtaccaata ttggcagcca actcgaagtg tttaccgtca gcagtcactg
     2101 tttgagcatc tttcaaaagt gcccattcag ctttttgttt cgcataggct tcaccagctg
     2161 ctttaaattc tgccgcttgt tcatctgttg ggttgataat cacttctcca gtgatcccgt
     2221 taacagcaag gatgtcaccg tctttaacga tttcagtgat gttatttgta cctaatacag
     2281 cagcaatttc aagtgtacgt gccatgatag ctgagtggct tgtacgtcca ccaatgttgg
     2341 ttacaaaagc ttttacaaag tttttgtcca attgagctgt atctgaagga gtcaagtcat
     2401 gcgcaatcac aatcacttct tcattgatag aagctgggtt tggcaatttt ttaccaagaa
     2461 ggtttgccaa tacacgtttt gtcacgtcgc ggatatccgc tgcgcgttct tgcatgtatg
     2521 ggttgtcttc catgccttca aagatagtga taaacatatc tgtaacttct ttcagacctg
     2581 cttctgcatt cactttcttc gcacggatag tttccttgat ttggctgatc atttctgggt
     2641 cagcaagaac cattaagtga gcatcaaaaa cttgagctgc ttcttcaccg agcgtaccta
     2701 ctgctttctc gcgaataaca gaaagctcgt cttgtgatgc ctgtagagcg gcatcaaggc
     2761 gagcttcttc tgcgtttgta tcttcgactg taatagtctc aaatgacaaa tccggctgaa
     2821 cgagtagata tgcttttgca actgcaacac cgtcagatgc tgcgattcct ttaagcattt
     2881 ctgtcatttc ccttatgcca atccttcttt ttccattgtt tctgagattg cagcgatagc
     2941 gtcatctgca tctgcacctt cagctgagat agttacgtca gcaccttgac caacaccaag
     3001 actcataaca cccataattg atttaaggtt aactgattta cctttgtact caagagtgat
     3061 atctgaagca aatttgctag cagtttgtac caacaatgtt gctggacgtg cgtgaatacc
     3121 tgtttctgcc actacgtgga aatctttaga agccatagtt tgactctcct tttgttcttt
     3181 ctttttttga gttatatgtg ataaccctta caatttagta ttataccatc ttctaggatt
     3241 tttttcaagc attttctgga ttttccttca atttcctttc agataacttg ctgaaaatct
     3301 tctatcctag ataacaaaac acaggatata gtttcttcaa aaacaattta taggataatc
     3361 attgctattt cacaatacaa acactatata ttgtgtttat atataaaaac aacaaaagaa
     3421 caccactata tttagtttaa atcattgaca aaattttatt ttctgatata ctaagatagt
     3481 attaaatttt gaagaggagt tacacaatgg taaccgttta ttctaaaaac aattgtgtcc
     3541 aatgtaaaat gaccaagcgt ttcttggaca gtaataatgt ctcttatcgt gaaatcaatc
     3601 ttgatgagca acctgagtac gtcgatcaag ttaaagagct cggttttagc gcagctcctg
     3661 ttatccaaac accaactgaa gtcttttcag gtttccaacc aggaaaactg aaacaattag
     3721 cataatctta gtacatcatc cagaagaaac tgcttttagg gctaacttag aagcctttct
     3781 tttgtaatta gataagggaa attttatggg attaaaacat cttgaagacg tgacttactt
     3841 ccgtcttaat aacgaaatta accgtcctgt taatggacaa atcatgcttc ataaagataa
     3901 ggaagccttg gatgctttct ttaaagaaaa tgtagttcca aacactatgg tttttgattc
     3961 aatcaaagac aaaatcaatt acctcattga acacaactac atcgaaacag cctttatcaa
     4021 gaaataccgt ccagagttct tggaagaatt ggctcaattt atcaaagacc aaaacttcca
     4081 attcaagtca ttcatggcag cttataaatt ttacaatcaa tatgccttaa agactaatga
     4141 cggtgaatac tatcttgaaa atatggaaga ccgtgtcttc ttcaacgccc tttatttcgc
     4201 tgatgggaat gaagctgttg caatcgatat tgccaatgaa atcatccacc aacgctacca
     4261 acctgctact ccttccttct tgaatgctgg acgtgctcgt cgtggggagt tggtatcttg
     4321 tttcctaatc caagtgacgg atgatatgaa ctctatcggg cgttctatca actcagctct
     4381 tcaactttca cgtattggtg gtggtgtggg aattaccctc agcaaccttc gtgaagctgg
     4441 tgcacctatc aaaggctatg aaggagctgc ttcaggtgtc gttcctgtta tgaagctttt
     4501 tgaagacagc ttctcttact ccaaccaatt ggggcaacgt caaggtgccg gcgttgtcta
     4561 cctcaacgtc tttcacccag atatcatcgc tttcctttca actaagaaag aaaacgctga
     4621 tgaaaaagta cgtgtcaaga ctctatcact tggtgttgta gtacctgata aattctacga
     4681 attggctcgt aaaaatgaag aaatgtacct cttcagccct tactctgtag aaaaagaata
     4741 cggtgtgcca ttcaattaca tcgacattac tgaaaaatac gatgaattgg tcgcaaatcc
     4801 aaatattcgc aagacaaaaa tcaaggcgcg ggatttggaa actgaaatct ctaaattgca
     4861 acaagagtct ggctatcctt atgtagtcaa catcgatacg gctaaccgtg caaatcctgt
     4921 tgatggaaag attatcatga gtaacttgtg ttctgagatt cttcaagttc aagaaccaag
     4981 cttgatcaac gatgctcaag aattccttca aatgggaaca gatgtttcat gtaacctggg
     5041 ttcaaccaac gtggttaaca tgatgacttc acctgatttt ggtcgttcta tccgtgctat
     5101 ggttcgtgcc cttactttcg ttacagatag ttcacatatc gtagctgtac caacgattga
     5161 ccatggaaat agccaagccc acacctttgg tctcggtgcc atgggactgc acagctacct
     5221 tgcccaacaa ctcattgaat atggttcacc tgagtctgtt gaatttacaa gcatctactt
     5281 tatgcttatg aactactgga ccttggtaga gtcaaacaat attgcacgtg aacgtggtat
     5341 taccttccac aactttgaaa aatcagacta tgctaacgga agttactttg acaagtatgt
     5401 aactggtgaa tttgttccaa catcagaccg tgttaaagaa ctcttcaaaa atgtttttat
     5461 ccctggtgtt gctgattggg ctgaacttcg cgacaaggtt caagaagatg gtctttacca
     5521 ccaaaatcgc cttgctgtag cgccaaatgg ttctatcagc tatatcaacg acgtttctgc
     5581 ttctatccac ccgattacgc aacgtatcga agaacgccaa gagaagaaaa ttggtaaaat
     5641 ctactaccct gctgctggct tgtctacaga aaccattcct tactacactt ctgcctacga
     5701 tatggatatg cgtaaagtca tcgatgttta cgctgctgcg actgaacacg tggatcaagg
     5761 actttcactc accctcttca tgcgcagtga cattccaaaa ggcctttacg aatggaagag
     5821 ggaaaataaa caaacgacac gtgatttgtc catccttcgt aactatgcct ttaacaaggg
     5881 aatcaagtct atctactacg tccgtacctt tacagatgac ggtggagaag tcggcgccaa
     5941 ccaatgtgaa agctgtgtga tttagtttct agcatagaaa cattattttt ccctaagcag
     6001 cactgataaa atcaaatcta ctatgtcata atataattta tgtaacattt taaaagtcgg
     6061 gcttccgact ttttgtgcga tactcctata gaattatggt aaagtagaaa taattgtgag
     6121 ttcgcaatac taaacacaga aagagatttt aaatggaaac ttactacaaa gccattaact
     6181 ggaatgccat cgaagatgtc atcgacaaat caacttggga aaaactgacg gagcaatttt
     6241 ggctcgatac acgtattccc ttatcaaacg acttggatga ctggagaaag ctatctaaca
     6301 aagagaaaga cttggtcgga aaagtttttg gtggtttaac ccttcttgac actatgcaat
     6361 ctgaaactgg ggttcaagcc cttcgcgcag acatccgtac accacatgag gaagctgttt
     6421 tcaataacat ccaatttatg gaatctgtcc acgctaaatc ttactcatca atcttttcta
     6481 ccttgaatac taaggctgag attgaagaaa ttttcgaatg gaccaatacc aatccttacc
     6541 tacaaaagaa ggctgagatt gtcaacgaaa tctacctaaa cggcagccca cttgaaaaga
     6601 aagttgccag cgtcttcctc gaaaccttcc tcttctactc tggtttcttc actcccctct
     6661 actatctcgg taacaacaaa ctagccaacg ttgcagaaat cattaaattg attattcgtg
     6721 acgagtctgt tcacggaacc tacattggtt acaaattcca acttggtttc aatgaattgc
     6781 ctgaagaaga gcaagaaaaa ctcaaagaat ggatgtacga cctactctat actctttatg
     6841 aaaatgaaga aggctacaca gagagtcttt atgacggtgt tggttggact gaagaggtta
     6901 aaaccttcct tcgctacaat gccaataaag ctctcatgaa catgggacaa gatccacttt
     6961 tcccagattc agctgaagat gtcaacccaa tcgttatgaa cggtatttca acaggaactt
     7021 ccaaccatga cttcttctct caagtcggaa atggttacct tcttggcgaa gttgaagcca
     7081 tgcaagatga tgactacaac tgcggtttgg actaatactc ttcgaaaatc aaattcaaac
     7141 cacgtcagct tcgc
//
LOCUS       DAVLHC010000075         6991 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.076, whole genome shotgun sequence.
ACCESSION   DAVLHC010000075 DAVLHC010000000
VERSION     DAVLHC010000075.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 6991)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6991)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6991
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.076"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            67..6498
                     /locus_tag="VXE25_001975"
     CDS             67..6498
                     /locus_tag="VXE25_001975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000750079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family serine peptidase"
                     /protein_id="HEV0772377.1"
                     /translation="MKKSTVLSLTTAAVILAAYAPNEVVLADTSSSEDALNISDKEKV
                     VLDKETENKEKHEDIHNAIETSKDTEEKKTTVIEEKEVVSKNPVIDTKTSNEEARIKE
                     DSNQSQGDNAHSSANKGTENPKKEDRLVYIAEFKDKESGEKAIKGLSNLKNTKVLYTY
                     DRIFNGSAIETTPDNLDKIKQIEGISSVERAQKVQPMMNHARKEIGVEEAIDYLKSIN
                     APFGKNFDGRGMVISNIDTGTDYRHKAMRIDDDAKASMRFKKEDLKGTDKNYWLSDKI
                     PHAFNYYNGGKITVEKYDDGRDYFDPHGMHIAGILAGNDTEQDIKNFNGIDGIAPNAQ
                     IFSYKMYSDAGSGFAGDETMFHAIEDSIKHNVDVVSVSSGFTGTGLVGEKYWQAIRAL
                     RKAGIPMVVATGNYATSASSSSWDLVANNHLKMTDTGNVTRTAAHEDAIAVASAKNQT
                     VEFDKVNIGGESFKYRNIGAFFDKNKITTNEDGTKAPSKLKFVYIGKGQDQDLIGLDL
                     RGKIAVMDRIYTKDLKNAFKKAMDKGARAIMVVNTVNYYNRDNWTELPAMGYEADEGT
                     KSQVFSISGDDGVKLWNMINPNKKTEVKRNNKEDFKDKLEQYYPIDMESFNSNKPNVG
                     DEKEIDFKFAPDTDKELYKEDIIVPAGSTSWGPRIDLLLKPDVSAPGKNIKSTLNVIN
                     GKSTYGYMSGTSMATPIVAASTVLIRPKLKEMLERPVLKNLKGDDKIDLTSLTKIALQ
                     NTARPMMDATSWKEKSQYFASPRQQGAGLINVANALRNEVVATFKNTDSKGLVNSYGS
                     ISLKEIKGDKKYFTIKLHNTSNRPLTFKVSASAITTDSLTDRLKLDETYKDEKSPDGK
                     QIVPEIHPEKVKGANITFEHDTFTIGANSSFDLNAVINVGEAKNKNKFVESFIHFESV
                     EEMEALNSNGKKINFQPSLSMPLMGFAGNWNHEPILDKWAWEEGSRSKTLGGYDDDGK
                     PKIPGTLNKGIGGEHGIDKFNPAGVIQNRKDKNTTSLDQNPELFAFNNEGINAPSSSG
                     SKIANIYPLDSNGNPQDAQLERGLTPSPLVLRSAEEGLISIVNTNKEGENQRDLKVIS
                     REHFIRGILNSKSNDAKGIKSSKLKVWGDLKWDGLIYNPRGREENAPESKDNQDPATK
                     IRGQFEPIAEGQYFYKFKYRLTKDYPWQVSYIPVKIDNTAPKIVSVDFSNPEKIKLIT
                     KDTYHKVKDQYKNETLFARDQKEHPEKFDEIANEVWYAGAALVNEDGEVEKNLEVTYA
                     GEGQGRNRKLDKDGNTIYEIKGAGDLRGKIIEVIALDGSSNFTKIHRIKFANQADEKG
                     MISYYLVDPDQDSSKYQKLGEIAESKFKNLGNGKEGSLKKDTTGVEHHHQENEESIKE
                     KSSFTIDRNISTIRDFENKDLKKLIKKKYKEEDDFVTGGKRTVELDYKYDDKGNITAY
                     EDESALEYETEKFDEIKSKIYGVLSPSKDGHFEILGKISNVSKNAKVYYGNNYKFIEI
                     KATKYDSHSKTMTFDLYANINDIVDGLAFAGDMRFFVKDDDRIKAETKIRMPEKNKET
                     KAEYPYVSSYGNVIELGEGDLSKNKPDNLTKMESGKIYSDSEKQQYLLKDNIILRKGY
                     ALKVTTYNPGKTDMLEGNGVYSKEDIAKIQKANPNLRVLSETTIYADSRNVEDGRSTQ
                     AVLMSALDGFNIIRYQVFTFKMNDKGEAIDKDGNLVTDSSKLVLFGKDDKEYTGEDKS
                     NVEAIKEDGSMLFIDTKPVNLSMDKNYFNPSKSNKIYVRNPEFYLRGKISDKGGFNWE
                     LRVNESVVDNYLIYGDLHIDNTRDFNIKLNVKDGDIMDWGMKDYKANGFPDKVTDMDG
                     NVYLQTGYSDLNAKAVGVHYQFLYDNVKPEVNIDPKGNTSIEYADGKSVVFNINDKRN
                     NGFDGEIQEQHIYVNGKEYTSFDDIKQITDKTLNIKIVVKDFARNTTVKEFILNKDTG
                     EVSELKPHRVTVTIQNGKEMSSTIVSEEDFILPVYKGELEKGYQFDGWEISGFEGKKD
                     AGYVINLSKDTFIKPVFKKIEEKKEEENKPTFDVSKKKDNPQVNHSQLNESHRKEDLQ
                     REDHSQKSDSTKDVTATVLDKNNISSKSTTNNPNKLPKTGTASGAQTLLAAGIMFIVG
                     IFLGLKKKNQD"
BASE COUNT         2746 a          948 c         1364 g         1933 t
ORIGIN      
        1 aacaaaggct agcaaagtta aagtttatta tctattggaa gttaaataaa tatgtaagga
       61 attaaaatga aaaaaagtac agtattgtca ttaaccacag ctgcagttat tttagcagcc
      121 tatgccccta atgaggtagt cttagcagac acatctagct ctgaagatgc tttaaacatt
      181 tctgataaag aaaaagtagt attagataag gaaacagaaa ataaagagaa acatgaagat
      241 attcataatg ctatagaaac ttcaaaggat actgaagaaa agaaaacaac agttattgag
      301 gaaaaagaag ttgttagtaa aaatcctgtg atagacacta aaactagcaa tgaagaagca
      361 agaatcaaag aagattccaa tcaatcccaa ggagataatg cacactcgtc tgcaaataaa
      421 ggcacagaaa atccgaaaaa agaagataga cttgtctata ttgctgaatt taaagataaa
      481 gaatctggag aaaaagcaat caagggacta tcaaatctta agaatacaaa agttttatat
      541 acttatgata gaatttttaa cggtagtgcc atagaaacaa ctccagataa cttggacaaa
      601 attaaacaaa tagaaggtat ttcatcggtt gaaagggcac aaaaagtcca acccatgatg
      661 aatcatgcca gaaaggaaat tggagttgag gaagctattg attacctaaa gtctatcaat
      721 gctccgtttg ggaaaaattt tgatggtaga ggtatggtca tttcaaatat cgatactgga
      781 acagattata gacataaggc tatgagaatc gatgatgatg ccaaagcctc aatgagattt
      841 aaaaaagaag acttaaaagg tactgataaa aattattggt tgagtgataa aatccctcat
      901 gcgttcaatt attataatgg tggcaaaatc actgtagaaa aatatgatga tggaagggat
      961 tattttgacc cacatgggat gcatattgca gggattcttg ctggaaatga tactgaacaa
     1021 gatatcaaaa actttaacgg catagatgga attgcaccta atgcacaaat tttctcttac
     1081 aaaatgtatt ctgacgcagg atctgggttt gcgggtgatg aaacaatgtt tcatgctatt
     1141 gaagattcta tcaaacacaa cgttgatgtt gtttcggtat catctggttt tacaggaaca
     1201 ggtcttgtag gtgagaaata ttggcaagct attcgggcat taagaaaagc aggcattcca
     1261 atggttgtcg ctacgggtaa ctatgcgact tctgcttcaa gttcttcatg ggatttagta
     1321 gcaaataatc atctgaaaat gaccgacact ggaaatgtaa cacgaactgc agcacatgaa
     1381 gatgcgatag cggtcgcttc tgctaaaaat caaacagttg agtttgataa agttaacata
     1441 ggtggagaaa gttttaaata cagaaatata ggggcctttt tcgataagaa taaaatcaca
     1501 acaaatgaag atggaacaaa agctcctagt aaattaaaat ttgtatatat aggcaagggg
     1561 caagaccaag atttgatagg tttggatctt aggggcaaaa ttgcagtaat ggatagaatt
     1621 tatacaaagg atttaaaaaa tgcttttaaa aaagctatgg ataagggtgc acgcgccatt
     1681 atggttgtaa atactgtaaa ttactacaat agagataatt ggacagagct tccagctatg
     1741 ggatatgaag cggatgaagg tactaaaagt caagtgtttt caatttcagg agatgatggt
     1801 gtaaagctat ggaacatgat taatcctaat aaaaaaactg aagtcaaaag aaataataaa
     1861 gaagatttta aagataaatt ggagcaatac tatccaattg atatggaaag ttttaattcc
     1921 aacaaaccga atgtaggtga cgaaaaagag attgacttta agtttgcacc tgacacagac
     1981 aaagaactct ataaagaaga tatcatcgtt ccagcaggat ctacatcttg ggggccaaga
     2041 atagatttac ttttaaaacc cgatgtttca gcacctggta aaaatattaa atccacgctt
     2101 aatgttatta atggcaaatc aacttatggc tatatgtcag gaactagtat ggcgactcca
     2161 atcgtggcag cttctactgt tttgattaga ccgaaattaa aggaaatgct tgaaagacct
     2221 gtattgaaaa atcttaaggg agatgacaaa atagatctta caagtcttac aaaaattgcc
     2281 ctacaaaata ctgcgcgacc tatgatggat gcaacttctt ggaaagaaaa aagtcaatac
     2341 tttgcatcac ctagacaaca gggagcaggc ctaattaatg tggccaatgc tttgagaaat
     2401 gaagttgtag caactttcaa aaacactgat tctaaaggtt tggtaaactc atatggttcc
     2461 atttctctta aagaaataaa aggtgataaa aaatacttta caatcaagct tcacaataca
     2521 tcaaacagac ctttgacttt taaagtttca gcatcagcga taactacaga ttctttaact
     2581 gacagattaa aacttgatga aacatataaa gatgaaaaat ctccagatgg taagcaaatt
     2641 gttccagaaa ttcacccaga aaaagtcaaa ggagcaaata tcacatttga gcatgatact
     2701 ttcactatag gcgcaaattc tagctttgat ttgaatgcgg ttataaatgt tggagaggcc
     2761 aaaaacaaaa ataaatttgt agaatcattt attcattttg agtcagtgga agaaatggaa
     2821 gctctaaact ccaacgggaa gaaaataaac ttccaacctt ctttgtcgat gcctctaatg
     2881 ggatttgctg ggaattggaa ccacgaacca atccttgata aatgggcttg ggaagaaggg
     2941 tcaagatcaa aaacactggg aggttatgat gatgatggta aaccgaaaat tccaggaacc
     3001 ttaaataagg gaattggtgg agaacatggt atagataaat ttaatccagc aggagttata
     3061 caaaatagaa aagataaaaa tacaacatcc ctggatcaaa atccagaatt atttgctttc
     3121 aataacgaag ggatcaacgc tccatcatca agtggttcta agattgctaa catttatcct
     3181 ttagattcaa atggaaatcc tcaagatgct caacttgaaa gaggattaac accttctcca
     3241 cttgtattaa gaagtgcaga agaaggattg atttcaatag taaatacaaa taaagaggga
     3301 gaaaatcaaa gagacttaaa agtcatttcg agagaacact ttattagagg aattttaaat
     3361 tctaaaagca atgatgcaaa gggaatcaaa tcatctaaac taaaagtttg gggtgacttg
     3421 aagtgggatg gactcatcta taatcctaga ggtagagaag aaaatgcacc agaaagtaag
     3481 gataatcaag atcctgctac taagataaga ggtcaatttg aaccgattgc agaaggtcaa
     3541 tatttctata aatttaaata tagattaact aaagattacc catggcaggt ttcctatatt
     3601 cctgtaaaaa ttgataacac cgcccctaag attgtttcgg ttgatttttc aaatcctgaa
     3661 aaaattaagt tgattacaaa ggatacttat cataaggtaa aagatcagta taagaatgaa
     3721 acgctatttg cgagagatca aaaagaacat cctgaaaaat ttgacgagat tgcgaacgaa
     3781 gtttggtatg ctggcgccgc tcttgttaat gaagatggag aggttgaaaa aaatcttgaa
     3841 gtaacttacg caggtgaggg tcaaggaaga aatagaaaac ttgacaaaga cggaaatacc
     3901 atttatgaaa ttaaaggtgc gggagattta aggggaaaaa tcattgaagt cattgcatta
     3961 gatggttcta gcaatttcac aaagattcat agaattaaat ttgctaatca ggctgatgaa
     4021 aaggggatga tttcctatta tctagtagat cctgatcaag attcatctaa atatcaaaag
     4081 cttggcgaga ttgcagaatc taaatttaaa aatttaggaa atggaaaaga gggtagtcta
     4141 aaaaaagata caactggggt agaacatcat catcaagaaa atgaagagtc tattaaagaa
     4201 aaatctagtt ttactattga tagaaatatt tcaacaatta gagactttga aaataaagac
     4261 ctaaagaaac tcattaaaaa gaaatataag gaagaagacg actttgtaac tggtggaaaa
     4321 agaacagtag aacttgatta taaatatgac gataaaggaa atataactgc ctatgaagat
     4381 gaaagtgctc tagaatatga aactgaaaaa tttgacgaaa taaaatcaaa aatttatggt
     4441 gttctaagcc catctaaaga tggacacttt gaaattcttg gaaagataag caatgtttct
     4501 aaaaatgcca aggtatatta tggaaataac tataaattta tagaaatcaa agcgactaag
     4561 tatgactcac attcaaaaac gatgacattt gatttatacg ctaatattaa tgatattgtg
     4621 gatggattag cttttgctgg agatatgcgg ttttttgtta aagatgatga tcgaataaaa
     4681 gctgaaacta aaattagaat gcctgaaaaa aataaggaaa ctaaagcaga atatccctat
     4741 gtatcaagtt atgggaatgt aatcgaatta ggagaaggag atctttcaaa gaacaaacca
     4801 gacaatttaa ctaaaatgga atctggtaaa atctattctg attcagaaaa acaacaatat
     4861 ctgttaaagg ataacatcat tctaagaaaa ggctatgcac taaaagtgac tacctataat
     4921 cctggaaaaa cggatatgtt agaagggaat ggagtctata gcaaggaaga tatagcaaaa
     4981 atacaaaagg ccaatcctaa tctaagagtc ctttcagaaa caacaattta tgctgatagt
     5041 agaaatgttg aagatggaag aagtacccaa gctgtattaa tgtcggcttt ggacggcttt
     5101 aacattataa ggtatcaagt gtttacattt aaaatgaacg ataaagggga agctatcgat
     5161 aaagacggaa atcttgtgac agattcttct aaacttgtat tatttggtaa ggatgataaa
     5221 gaatacactg gagaggataa gtccaatgta gaagctataa aagaagatgg ctccatgtta
     5281 tttattgata ccaaaccagt aaacctttca atggataaga actactttaa tccatctaaa
     5341 tctaataaaa tttatgtacg aaatccagaa ttttatttaa gaggtaagat ttctgataag
     5401 ggtggtttta actgggaatt gagagttaat gaatcggttg tagataatta tttaatctac
     5461 ggagatttac acattgataa cactagagat tttaatatta agttgaatgt taaagacggt
     5521 gacatcatgg actggggaat gaaagactat aaagcaaacg gatttccaga taaggtaaca
     5581 gatatggatg gaaatgttta tcttcaaact ggctatagcg atttgaatgc taaagcagtt
     5641 ggagtccact atcagttttt atatgataat gttaaacccg aagtaaacat tgatcctaag
     5701 ggaaatacta gtatcgaata tgctgatgga aaatctgtag tctttaacat caatgataaa
     5761 agaaataatg gattcgatgg tgagattcaa gaacaacata tttatgtaaa tggaaaagaa
     5821 tatacatcat ttgatgatat taaacaaata acagacaaga cactaaacat taagattgtt
     5881 gtaaaagatt ttgcaagaaa tacaaccgta aaagaattca ttttaaataa agatacggga
     5941 gaggtaagtg aattaaaacc tcatagggta actgtgacca ttcaaaatgg aaaagaaatg
     6001 agttcaacga tagtgtcgga agaagatttt attttacctg tttataaggg tgaattagaa
     6061 aaaggatacc aatttgatgg ttgggaaatt tctggtttcg aaggtaaaaa agacgctggc
     6121 tatgttatta atctatcaaa agataccttt ataaaacctg tattcaagaa aatagaggag
     6181 aaaaaggagg aagaaaataa acctactttt gatgtatcga aaaagaaaga taacccacaa
     6241 gtaaaccata gtcaattaaa tgaaagtcac agaaaagagg atttacaaag agaagatcat
     6301 tcacaaaaat ctgattcaac taaggatgtt acagctacag ttcttgataa aaacaatatc
     6361 agtagtaaat caactactaa caatcctaat aagttgccaa aaactggaac agcaagcgga
     6421 gcccagacac tattagctgc cggaataatg tttatagtag gaatttttct tggattgaag
     6481 aaaaaaaatc aagattaaga taaaagctat agaaaaaaat ggtttatgta ctgagattag
     6541 atagtgaggt gatgacatag ttttgtgaaa acagccattt ataactcaat tatttagttt
     6601 acttcactat tgatactatt tggagttatt aatggactta gtttagataa ctaatgaatt
     6661 gattgaaagg gttagtattg acaatattgg tcatattgat tagaaaatag agtctatcaa
     6721 aatttaaagg ctaatagagg tgatgagaca atttcaagga attaagtagc gtttggttgc
     6781 ttaattcctt tttatttgga aggaagtttt tcgtaaccgc ccaataacga agtctattgg
     6841 gcggttacga tatgatcact gacttcgtca gttctatcta caacctaaaa acagtgtttt
     6901 gaacaacctg cggctagctt cctagtttgc tctttgattt tcattgaata ttagaacagc
     6961 aaaaatgctt ggagtatttg tttgtgtgtt t
//
LOCUS       DAVLHC010000076         6883 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.077, whole genome shotgun sequence.
ACCESSION   DAVLHC010000076 DAVLHC010000000
VERSION     DAVLHC010000076.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 6883)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6883)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6883
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.077"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            111..212
                     /locus_tag="VXE25_001976"
                     /pseudo
     CDS             111..212
                     /locus_tag="VXE25_001976"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000234126.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin peptidase"
     gene            complement(184..960)
                     /locus_tag="VXE25_001977"
     CDS             complement(184..960)
                     /locus_tag="VXE25_001977"
                     /EC_number="4.2.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan synthase subunit alpha"
                     /protein_id="HEV0772378.1"
                     /translation="MPKTLTEKLNAIKVTGKGIFVPYIMAGDHEKGLDGLAETIHFLE
                     DLGVSAIEVGIPFSDPVADGPVIEEAGLRSLAHGTSTQALVETLKTIETEIPLVIMTY
                     FNPLFQYGVENFVKDLADTAVKGLIIPDLPHEHANFVEPFLADTDIALIPLVSLTTGI
                     ERQKELIEGAEGFVYAVAINGVTGKSGNYRADLDKHLAQLHQVADIPVLTGFGVSSQA
                     DLERFNAVSDGVIVGSKIVKALHQGEPIQDFIRQAVAYQK"
     gene            complement(953..2176)
                     /gene="trpB"
                     /locus_tag="VXE25_001978"
     CDS             complement(953..2176)
                     /gene="trpB"
                     /locus_tag="VXE25_001978"
                     /EC_number="4.2.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan synthase subunit beta"
                     /protein_id="HEV0772379.1"
                     /translation="MAYQEPNKDGFYGKFGGRFVPETLMTAVLELEKAYRESQADPSF
                     QEELNQLLRQYVGRETPLYYAKNLTQHIGGAKIYLKREDLNHTGAHKINNALGQVWLA
                     KRMGKKKIIAETGAGQHGVATATAAALFNMECTIYMGEEDVKRQALNVFRMELLGAKV
                     EAVTDGSRVLKDAVNAALRSWVANIDDTHYILGSALGPHPFPEIVRDFQSVIGREAKQ
                     QYRDLTGRDLPDALVACVGGGSNAIGLFHPFVEDESVAMYGTEAAGLGVDTEHHAATL
                     TKGSPGVLHGSLMDVLQDAHGQILEAFSISAGLDYPGIGPEHSHYHDIKRASYVPVTD
                     EEALEGFQLLSRVEGIIPALESSHAIAFAVKLAKELGPEKSMIVCLSGRGDKDVVQVK
                     DRLEADAAKKGEAHA"
     gene            complement(2154..2753)
                     /locus_tag="VXE25_001979"
     CDS             complement(2154..2753)
                     /locus_tag="VXE25_001979"
                     /EC_number="5.3.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000169895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylanthranilate isomerase"
                     /protein_id="HEV0772380.1"
                     /translation="MTKVKICGLSTKEAVETAVSAGADYIGFVFAPSKRQVTLEEVAE
                     LAKLIPADVKKVGVFVSPSRAELLEAIDKVGLDLVQVHGQVADDLFENLPCASIQAVQ
                     VDGEGHVPNSQADYLLFDAPVAGSGQPFDWGQLDTTGLAQPFFIAGGLNEDNVVKAIQ
                     HFTPYAVDVSSGVETDGQKDHEKIRRFIERVKNGISRTK"
     gene            complement(2740..3507)
                     /gene="trpC"
                     /locus_tag="VXE25_001980"
     CDS             complement(2740..3507)
                     /gene="trpC"
                     /locus_tag="VXE25_001980"
                     /EC_number="4.1.1.48"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011227478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="indole-3-glycerol phosphate synthase TrpC"
                     /protein_id="HEV0772381.1"
                     /translation="MSQEFLARILEQKVREVEQMKLEQIQPLRQTYRLAEFLKNHQDR
                     LQVIAEVKKASPSLGDINLDVDIVQQAQTYEENGAVMISVLTDEVFFKGHLDYLREIS
                     SQVEIPTLNKDFIIDEKQIIRARNAGATVILLIVAALSEERLKELYDYATELGLEVLV
                     ETHNLAELEVAHRLGAEIIGVNNRNLTTFEVDLQTSVDLAPYFEEGRYYISESAIFTG
                     QDAERLAPYFNGILVGTALMQAENVAQRIKELQIDKG"
     gene            complement(3504..4508)
                     /gene="trpD"
                     /locus_tag="VXE25_001981"
     CDS             complement(3504..4508)
                     /gene="trpD"
                     /locus_tag="VXE25_001981"
                     /EC_number="2.4.2.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517337.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anthranilate phosphoribosyltransferase"
                     /protein_id="HEV0772382.1"
                     /translation="MKEIIEKLAKFENLSGVEMTDVIERIVTGRVTEAQIASLLLALK
                     MKGETPEERTAIAQVMRGHAQHIPTEIHDAMDNCGTGGDKSFSFNISTTAAFVLAGGG
                     IHMAKHGNRSISSKSGSADVLEALGINLDLKPAELGKVFDKTGIVFLFAKNMHPAMKY
                     IMPARLELGIPTIMNLTGPLIHPMALETQLLGISRPELLESTAQVLKNMGRKRAIVVA
                     GPEGLDEAGLNGTTKIALLENGEISLSSFTPEDLGMEGYAMEDIRGGNAQENAEILLS
                     VLKNEASPFLETTVLNAGLGFYANGKIDSIKEGVALARQVIARGKALEKLRLLQEYQK
                     "
     gene            complement(4519..5085)
                     /locus_tag="VXE25_001982"
     CDS             complement(4519..5085)
                     /locus_tag="VXE25_001982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminodeoxychorismate/anthranilate synthase
                     component II"
                     /protein_id="HEV0772383.1"
                     /translation="MILLIDNYDSFTYNLAQYIGNFAEVQVLRNDDSKLYEEAEKADG
                     LVFSPGPGWPVDAGKMEDMIRDFAGKKPILGICLGHQAIAEVFGGKLGLAPKVMHGKQ
                     SNINFEAPSVLYQGIEEGRAVMRYHSILIEEMPEDFEVTARSTDDQAIMGIQHKNLPI
                     YGFQYHPESIGTPDGLSSIRNFIEKVVK"
     gene            complement(5082..6443)
                     /gene="trpE"
                     /locus_tag="VXE25_001983"
     CDS             complement(5082..6443)
                     /gene="trpE"
                     /locus_tag="VXE25_001983"
                     /EC_number="4.1.3.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398943.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anthranilate synthase component I"
                     /protein_id="HEV0772384.1"
                     /translation="MERIIHGDVLSPILAYMRLKGQHKVILESIPRDKETARFYILAY
                     NPVFEIKFENGVLYQNGQVIDRDPLDFLYEVIHKSQHHSELPFGGGAIGFVGYDMISL
                     YEEIGQIPEDTIGTPDMHFFVYESYMVFDHKKEKIHVIEDALYSERSQEALEKSLNQV
                     LEELRIPAPNEFEDLDLSPLDFKPHIAPHKFEGMVETARDLIRNGDMFQCVLSQRFSA
                     EVTGNPFDFYRNLRVTNPSNYLYFYDFGDYQIIGASPESLVSVKNGIVTTNPIAGTRP
                     RGATDEEDKTLATDLLSDEKETAEHRMLVDLGRNDIGRISETASVQVTKYMKVELFRY
                     VMHLTSVVKGRLLPELTAMDALKATLPAGTVSGAPKIRAMRRIYELETEKRGVYAGAI
                     GYLSATGDMDLAIAIRTMILKNQRAYVQAGAGIVYDSIAQNEYQETINKAKSMTRIGE
                     LRP"
BASE COUNT         1820 a         1720 c         1371 g         1972 t
ORIGIN      
        1 tatagtaaaa tcaattaaaa actgaacaaa tttattggga aattcaaatc gctttctgaa
       61 aatattttag gaaccgtagt gtaatattcc agattcaatt cactataaaa ctgacctttc
      121 tcctgcaaaa gaaaaaggaa agacttcctt tcgtgccttt cctcttactt gctacttgtt
      181 tgattatttt tggtaagcta ctgcttgtct gataaaatcc tgaatcggct ctccttggtg
      241 gagagctttt actatttttg aaccgacgat aacaccatct gacaccgcat tgaagcgttc
      301 cagatcggct tgactagata caccaaaacc tgtcaagact gggatgtcgg ccacttgatg
      361 aagttgcgcc aagtgcttgt ccaaatctgc acggtaattg cctgatttcc ctgtcacccc
      421 attgatggca acggcataga cgaatccctc cgccccttca atcaactctt tctggcgctc
      481 aattcctgtg gtcaagctta ctaaaggaat caaggcgata tctgtatctg ccaaaaatgg
      541 ttctacaaag ttggcatgtt catgaggcag gtctgggata atcaagccct tcacagctgt
      601 atcagccaga tctttgacaa agttctccac accgtactga aagagggggt tgaagtaggt
      661 catgatgacc agtggaatct ctgtttcaat ggttttcaag gtttcaacta aagcctgggt
      721 agaggtcccg tgggctaaac tgcgcaagcc agcttcttcg ataacaggtc catctgcaac
      781 agggtctgaa aagggaatcc ccacttcaat agcagagaca cccaaatctt ctaaaaagtg
      841 aattgtttca gcaagaccgt ccaaaccttt ttcgtggtca ccagccatga tataaggaac
      901 gaaaattcct tttccagtta cttttatagc attcaatttt tctgttagtg tcttaggcat
      961 gagcttctcc cttctttgct gcatctgctt ccaagcggtc tttgacttga accacatcct
     1021 tgtccccacg acctgatagg cagacaatca tagacttttc tggtccaagt tctttggcca
     1081 atttcaccgc aaaagcgata gcatggctag attccaaggc tgggataatc ccttccacac
     1141 gagacaagag ttgaaatcct tccaaagctt cttcgtctgt cacagggaca tagctggcac
     1201 gtttgatatc gtggtagtga gaatgctctg gaccgatacc aggatagtcc aaacctgctg
     1261 agatagagaa ggcttcaaga atttgaccat gggcatcttg gagcacatcc atgagagaac
     1321 cgtgaagaac acccggacta cccttggtca aggtagcagc gtggtgctct gtatccacac
     1381 caagccctgc tgcttcagtt ccatacatag ctactgactc atcttctaca aagggatgga
     1441 agagcccgat agcattcgac ccaccaccaa cacaggctac tagggcatct ggcagatctc
     1501 gacctgtcaa gtcacggtac tgttgtttag cctctcgacc gatgacactt tggaagtcac
     1561 gaacgatttc tggaaatgga tgaggcccca aggcagaacc aaggatatag tgggtatcgt
     1621 cgatattagc cacccatgaa cgaagggctg cattgaccgc atccttgagc acgcgcgaac
     1681 catctgtcac ggcctcgacc ttagctccca aaagctccat acggaagaca ttgagggctt
     1741 ggcgtttgac atcttcctca cccatgtaga tggtacattc catgttaaag agggccgcag
     1801 cagttgcagt tgccacaccg tgctgaccag cacccgtttc tgcgataatt ttctttttac
     1861 ccatgcgttt ggcaagccaa acttgtccta aggcattgtt aatcttgtgg gctcctgtat
     1921 ggttaaggtc ttcccgtttg agataaatct tggctccgcc gatatgctgg gtcaagtttt
     1981 ttgcgtagta aaggggagtt tcacgtccca catactggcg caaaagctgg tttaattcct
     2041 cttggaaact tgggtctgcc tgactttcac ggtaggcctt ctccaactcc aaaactgctg
     2101 tcatcaatgt ttctgggaca aaacgtccgc caaattttcc gtaaaatcca tctttatttg
     2161 gttcttgata tgccattctt taccctctct ataaatcttc taatcttttc atgatctttt
     2221 tgtccatctg tctccactcc gcttgataca tctactgcat agggagtaaa gtgttgaatt
     2281 gcttttacta cattatcttc attaaggcca cctgcgataa agaagggctg tgctagtcca
     2341 gtcgtatcca gttgacccca atcaaagggc tggccactcc cagccacagg ggcatcaaag
     2401 agtagatagt ctgcctgaga attgggcaca tgaccctctc catctacctg cacagcctga
     2461 atgctagcac aaggcaaatt ctcaaataaa tcatctgcca cctgaccgtg aacttgaacc
     2521 aagtccaagc caactttgtc aatcgcttcc agcagttctg cccgacttgg tgaaacaaat
     2581 acaccaacct ttttgacatc tgcaggaata agctttgcca actcagctac ttcttctaaa
     2641 gttacctgtc ttttactagg tgcaaagaca aaaccgatat agtcggctcc tgctgaaacg
     2701 gctgtttcca ccgcttcttt ggtcgatagt ccacaaattt taacctttgt caatctgcaa
     2761 ctccttgatt ctctgggcca cattttctgc ctgcataaga gctgtcccta ccaaaattcc
     2821 gttaaagtat ggggctagtc gttccgcatc ctgccctgtg aaaatggcag attcagaaat
     2881 gtaatagcga ccttcctcaa agtaaggggc taaatctaca ctggtctgca agtcgacctc
     2941 aaaggtagtc aagttgcggt tgttgacccc gataatctca gcaccaagtc tgtgggctac
     3001 ctctagttca gctagattgt gagtctccac taagacttcc agaccaagct ctgtcgcgta
     3061 gtcatacagt tccttgaggc gttcttcgga caaggctgcc acaatgagca agataactgt
     3121 cgcacctgca ttgcgagcgc ggatgatttg cttttcatcg atgataaagt ctttgttgag
     3181 cgtcggaatc tctacctgac tggaaatttc ccgtagataa tccaaatgcc ctttaaagaa
     3241 aacctcatct gtcaacaccg aaatcatcac tgctccgttt tcttcataag tctgggcctg
     3301 ttgcacaata tccacatcga gattgatatc tcccaaacta gggctagctt tcttgacctc
     3361 agcgattacc tgcaagcggt cctgatgatt cttcaaaaac tctgccaagc gataggtctg
     3421 gcgcagaggc tggatttgct ccagcttcat ctgctccacc tcacgcacct tctgctctaa
     3481 gattcgtgct aaaaattcct gactcatttt tggtactcct gtaacagtct gagtttttca
     3541 agggccttgc ctctagcaat cacttgacgg gccaaggcaa ctccttcctt gatgctatca
     3601 atcttaccat tagcatagaa accaagacca gcattcaaga ctgtcgtttc caagaatgga
     3661 cttgcttcgt ttttcagaac gctaagcaaa atttctgcat tttcctgagc attcccacca
     3721 cgaatatctt ccatagcata gccttccatt cccaaatcct ctggagtaaa gcttgacaag
     3781 ctgatttcgc cattttcaag aagtgcaatc ttggttgttc cgttcaagcc agcttcatcc
     3841 aacccttctg gtccagcaac cacgatggca cgtttgcgac ccatattttt caaaacctga
     3901 gctgtacttt ctaggagttc tggacgacta attccaagaa gctgtgtttc taaagccatt
     3961 ggatgaatca gtggaccagt caagttcata atcgttggaa ttcccaattc caaacgagct
     4021 ggcatgatgt atttcatagc tgggtgcata tttttagcga agagaaagac gattccagtt
     4081 ttatcaaaga ccttacctag ttcagctggt ttgaggtcaa gattgattcc caaggcttcg
     4141 aggacatctg cggaaccaga tttagaagaa atcgagcggt taccatgctt ggccatgtga
     4201 ataccgccac cagccaagac aaaggctgca gttgtggaaa tattaaaact gaaagacttg
     4261 tccccacctg taccacagtt gtccatggca tcatgaatct cagttggaat atgctgggca
     4321 tgtcctctca tgacttgggc aatggctgtg cgttcttcag gtgtttcccc cttcatctta
     4381 agagctaaga ggagagaagc aatctgcgct tcagttacac gcccagttac gatacgctca
     4441 atgacatccg tcatttccac acctgataaa ttttcaaatt ttgctagttt ttcaataatc
     4501 tctttcatcc tagtttcctc actttacaac cttctcgata aaattccgaa tagaagacaa
     4561 gccgtctggc gttccaatgc tctctggatg gtactggaag ccataaatcg gtaggttttt
     4621 atgttgaatc cccatgatgg cttggtcatc agtcgaacga gctgtcactt caaagtcttc
     4681 tggcatttcc tcaatcaaaa tactgtgata acgcatgacc gcacgtcctt cctcaatacc
     4741 ttgatacaaa acagatggcg cttcaaagtt gatattgctc tgtttcccat gcatgacttt
     4801 tggagccaaa cctagcttac caccaaagac ttctgcaatg gcttggtggc ccaaacaaat
     4861 cccaagaatc ggcttcttgc ctgcaaaatc acgaatcatg tcttccatct ttccagcatc
     4921 aactggccaa ccaggaccag gagaaaaaac cagaccatct gctttttcag cttcttcata
     4981 cagcttggaa tcatcatttc tcagaacctg aacttctgca aaattcccaa tgtattgggc
     5041 caagttatag gtaaaagaat catagttgtc aatcaataaa atcatggtct tagttctcca
     5101 attctagtca tagattttgc tttgttaatg gtttcttggt attcgttttg ggcgatagag
     5161 tcgtagacaa tccctgcccc agcctgcaca taggctcttt gatttttgag aatcatggtt
     5221 cggatggcaa tggccaaatc catatcaccc gtcgcagaca agtagccgat tgctcctgca
     5281 tatacgcccc gtttttccgt ttccagttca tagatgcgtc tcatcgcccg aatctttggt
     5341 gctccagaaa cggttccagc aggaagtgta gctttcaagg catccatggc cgtgagttct
     5401 ggaagcaaac gccccttgac cacgctggtc aaatgcatga cgtagcggaa gagctccacc
     5461 ttcatatact tagtaacttg gacactggcc gtttcagaga tgcggccaat atcgttacgc
     5521 cccaagtcta ccaacattcg atgttctgct gtttccttct catcagagag gaggtcagtc
     5581 gccaaggtct tgtcttcttc atccgtagcc cctcttggtc gcgtccctgc aatcggattg
     5641 gttgtcacga tgccattttt gacagaaact aaactttctg gactagctcc gatgatttga
     5701 taatccccaa aatcatagaa ataaaggtaa ttagaaggat tagtcacgcg gagatttctg
     5761 tagaagtcaa atggatttcc agtaacttct gctgaaaaac gctggctgag tacacattgg
     5821 aacatatctc cgttacgaat caagtcacga gctgtttcta ccattccctc aaacttatgt
     5881 ggagcgatat gcggtttgaa gtctaacgga gatagatcca aatcttcaaa ttcatttgga
     5941 gcaggaatgc gtaattcctc aagcacttgg ttcaaggatt tttccaaggc ctcttgactg
     6001 cgctcactat aaagtgcatc ctctatgaca tgtatcttct ccttcttgtg gtcaaagacc
     6061 atatagctct catagacaaa gaaatgcatg tctggcgtcc caattgtatc ctcagggatt
     6121 tgaccaattt cttcataaag cgaaatcata tcgtaaccca caaaaccaat ggctccacca
     6181 ccaaaaggta gctctgagtg gtgctgactc ttatgaatca cttcataaag gaaatccaag
     6241 ggatcccgat caatcacttg accattttga tagagaaccc cattttcaaa cttaatctca
     6301 aaaactggat tataggctag gatataaaaa cgagctgttt ccttgtctct cggaatactc
     6361 tctaaaataa ccttatgttg cccctttaag cgcatataag ccaagattgg tgataagaca
     6421 tctccatgaa tgattcgttc cattgtaatt tccctttcag ttctacttct agtccgtggt
     6481 gactgtatga aaaatcccca cgcaaaataa cttgcgtgag gacgaaattc gcggtgccac
     6541 ctcaattata ggatttctcc tatctctcat tcctgtctca gatatctcct gtaacaggct
     6601 gtgcgataaa gggcactccc ttgagaatga tgttttcttc tctcgtttca gatgaaccca
     6661 actttacagc tttctctgct tgttttcagc aaccacaagc tctctgtgag agaaagaact
     6721 gtaatttttc catctattat tttttagctt ctagtaatct gcaatcgcag ctaggtcctt
     6781 gcctccacga ccagagacat tgatgaagag atgttcatct cggtacacct ttatactctt
     6841 cgaaaatctc ttcaaaccgc gtcaacgtcg ccttatcgta ggt
//
LOCUS       DAVLHC010000077         6807 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.078, whole genome shotgun sequence.
ACCESSION   DAVLHC010000077 DAVLHC010000000
VERSION     DAVLHC010000077.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 6807)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6807)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6807
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.078"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            87..3437
                     /locus_tag="VXE25_001984"
     CDS             87..3437
                     /locus_tag="VXE25_001984"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000526318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase family protein"
                     /protein_id="HEV0772385.1"
                     /translation="MGNFSFLLKNDEYESFSKPCIEAENMIATSTVATAFMARRALEQ
                     AVHWIYSHDSYLEAPYRATLSSLVWDDDFRDIVDSELHKQIVLLIRWGNHAAHGGEIK
                     EREAILALHHLYQFVNFIDYCYSNEFVERYFDEKCLPLSANIKYRETPQSMIKLQDSL
                     PELPDFHEQMAAQSVEVQETYTEKRETAAQRQDVPFHIEQLSEAETRKLFIDIDLRLA
                     GWIFEENCRVEIAVDGLKHGSGIGYCDYVLYGKNGKILAIVEAKKASVNPEVGEVQVK
                     EYAEALEKHIGYQPICFITNGLKHYILDGPNRRQIAGFYSQEELQLVMDRRHLQKPLE
                     DISSKIRDDISGRHYQKHAIASVCEAFSNHRRQALLVMATGAGKTRTAVSLVDILSRH
                     NWVKNVLFLADRTSLVKQAYDSFRKLLPDLSVCNFLEDKEGAQSSRMVFSTYPTMIGA
                     ISGQEEVNQRPFTVGHFDLIIIDESHRSIYQKYKSIFDYFDARIVGLTATPRQDLDKN
                     TYGFFNLENGVPTYAYDLEEAVKDGYLVAYHSIETKLKLPTDGLHYDDLSEEEKEHFD
                     SKFEDDSCEKDIDGSVFNSFIFNKSTVEIVLNELMTRGIQTASGDEIGKTIIFAKNHD
                     HAEYIRGIFNNRYPEKGSDYAQVIDYSIKHYQTLIDDFKIKEKYPQIAISVDMLDTGI
                     DVPEVVNLVFFKKVRSKTKFWQMIGRGTRLCKDLFGPEQDKENFLVFDYGDNFDYFRA
                     DPRDGEGRHIVSLTQRLFNIKVDLIRELQGLQYQEDQFARAYRQQLVSELQGRIESLN
                     ELDFRVRMVLDTVYSYRKLESWQNLTAVTSETIQKNLSPLLFDEDKEDEMARRFDLWL
                     LHIQLGQLTAKSSTVHISQVMKTARALSAIGNIPQVFEQAEIIRKVQEPEFWKEVNLS
                     DLEKIRLAIRDLLQFLDKTDRKPYYVNFEDRILSTVHETTAFLQVNDLRSYNEKVEHY
                     LKTHLDEESISKLYHNKKLTSDDMLALEKLLWEKLGSKADYQSHYENKAIPRLVREII
                     GLDRESANRIFSKFLSDENLNARQISFVKLIVDYIVENGFLETKVLTQEPFKSYGSVQ
                     LLFQHQLPVLRNIVQIIELINNRAGEAA"
     gene            complement(3943..4413)
                     /locus_tag="VXE25_001985"
     CDS             complement(3943..4413)
                     /locus_tag="VXE25_001985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001043003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine repressor"
                     /protein_id="HEV0772386.1"
                     /translation="MNKSEHRHQLIRALITKNKIHTQAELQALLAENDIQVTQATLSR
                     DIKNMNLSKVREEDSAYYVLNNGSISKWEKRLELYMEDALVWMRPVQHQVLLKTLPGL
                     AQSFGSIIDTLSFPDAIATLCGNDVCLIICEDADTAQKCFEELKKFAPPFFFEE"
     gene            complement(4430..6703)
                     /locus_tag="VXE25_001986"
     CDS             complement(4430..6703)
                     /locus_tag="VXE25_001986"
                     /EC_number="3.4.14.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Xaa-Pro dipeptidyl-peptidase"
                     /protein_id="HEV0772387.1"
                     /translation="MRFNQYSYINFPKENVLSELKKCGFDLQNTANHKDSLETFLRRF
                     FFTYQDTNYPLSILAADKKTDLLTFFQSEDELTADIFYTVAFQLLGFSYLVDFEDSDV
                     FRKETGFPIIYGDLIENLYQLLNTRTKKGNTLIDQLVSDGLIPEDNDYHYFNGKSLAT
                     FSNQDVIREVVYVESRVDTDQKGLSDLVKVSIIRPRFDGKIPAIMTASPYHQGTNDKA
                     SDKALYKMEGELEVKLPHKIELEKPQLNLVQPQGKAELIAEAEEKLTHINSSYTLNDY
                     FLPRGFANLYVSGVGTKDSTGFMTNGDYQQIEAYKNVIDWLNGRCRAFTDHTRQRQVK
                     ADWSNGKVATTGLSYLGTMSNGLATTGVDGLEVIIAEAGISSWYNYYRENGLVTSPGG
                     YPGEDFDSLAELTYSRNLLAGDYIRGNEAHQADLEKVKAQLDRKTGDYNQFWHDRNYL
                     LNAHKVKAEVVFTHGSQDWNVKPLHVYQMFHALPTHIHKHLFFHNGAHVYMNNWQSID
                     FRESINALLTKKLLGQETDFQLPTVIWQDNTAPQTWLSLDNFGGQENCETFSLGQEEQ
                     AIQNQYPDKDFERYGKTYQTFNTELYQGKANQITINLPVTKDLHLNGRAQLNLRIKSS
                     TNKGLLSAQLLEFGQKKYLQPYPAILSARTIDNGRYHMLENLCELPFRPEAQRVVTKG
                     YLNLQNRNDLLLVEDITADEWMDVQFELQPTIYKLKEGDTLRLVLYTTDFEITIRDNT
                     DYHLTVDLAQSMLTLPC"
BASE COUNT         2081 a         1146 c         1477 g         2103 t
ORIGIN      
        1 gcttgtgaga tagctataaa agtgtggaga aatagcttga aatttagtat aatatagcta
       61 aactatttgt ttaaagtgag aaaaaaatgg gaaattttag ctttctttta aaaaatgacg
      121 aatatgaatc tttttcaaaa ccttgcattg aagctgaaaa tatgattgct acatcaactg
      181 tggctactgc ctttatggcg cgtcgtgctt tggagcaggc tgtccattgg atatatagtc
      241 acgattcata tttagaagct ccctatcgtg ctactctatc ttctttagta tgggatgatg
      301 attttaggga tatcgtagat tctgaactcc acaagcagat agttctgttg attcggtggg
      361 gaaaccatgc tgctcatggt ggtgaaatta aggaacgaga agcgatttta gctttacatc
      421 atttgtatca gtttgttaat tttatcgatt attgttacag caatgaattt gtggagcgtt
      481 attttgatga gaagtgctta ccactttcag caaacatcaa ataccgagaa actccacaat
      541 ctatgataaa gttacaagac agtttaccag aactgcctga ttttcatgaa cagatggctg
      601 ctcagtccgt agaagttcaa gagacttata ctgaaaaacg tgagactgca gcgcaacggc
      661 aagatgtgcc tttccatatt gaacaattat ctgaggcaga gacaagaaag ctctttattg
      721 atatcgatct ccgtttagca ggatggatat ttgaagaaaa ctgtcgtgtt gagatagccg
      781 ttgatggtct caagcacggt tcaggaattg gttactgtga ctacgtactt tatggtaaaa
      841 atgggaaaat tttagcgatt gtggaggcta aaaaagcctc tgtcaatcca gaagtagggg
      901 aagtacaggt caaagaatat gctgaagctt tggagaaaca tatcggctat cagccaattt
      961 gctttattac aaatgggttg aagcactata tacttgatgg tccgaaccgc cgccagattg
     1021 caggctttta ctctcaagaa gaattgcaat tagtgatgga tagacgtcat cttcaaaaac
     1081 cgcttgagga tatttctagt aaaattaggg acgatatttc cgggcgtcac taccaaaaac
     1141 atgccattgc aagcgtttgt gaagctttct ctaatcatcg tagacaggca cttttggtta
     1201 tggcaactgg ggcggggaaa actcgtacag cagtttctct agttgatatc ttatcacgtc
     1261 ataactgggt aaaaaacgtt ctcttcttag ccgatagaac ttccttggtt aagcaagcct
     1321 atgattcgtt tagaaaatta ctcccagatc tttccgtttg taacttctta gaagataaag
     1381 aaggagctca atcaagtcgt atggtctttt caacttatcc gaccatgatt ggagcgatta
     1441 gtggtcaaga agaagtaaat caacgccctt ttactgttgg gcattttgac cttatcataa
     1501 ttgacgaatc tcaccgttct atttatcaga aatacaagtc catttttgat tattttgatg
     1561 caagaattgt aggcttaaca gctactccgc gtcaagattt agataaaaac acctatggat
     1621 tctttaattt ggagaatggg gttccaacat atgcatatga tttggaagag gctgttaaag
     1681 acggatattt agtagcctat cattctatcg aaaccaaact gaaactacct acggatggtc
     1741 tacattatga tgatttgtcc gaagaagaaa aggaacattt tgatagcaaa tttgaagacg
     1801 atagctgtga aaaagatatt gatgggagtg tgtttaattc ctttattttc aataaaagta
     1861 cagtagaaat tgttttaaat gaactcatga caagaggaat tcagacagcc tcgggtgatg
     1921 aaattggtaa aactattatt tttgctaaaa atcatgacca tgcggaatat atcagaggta
     1981 tttttaacaa ccgctatcct gaaaaaggga gcgactatgc tcaggtgatt gattatagta
     2041 ttaagcatta tcagaccttg attgatgatt ttaaaattaa ggagaagtat cctcaaattg
     2101 cgatttctgt cgatatgtta gatacaggta ttgatgtacc agaggttgtt aatttagtct
     2161 tcttcaagaa agtacgctct aaaactaagt tttggcagat gattggtcga ggaacccgtc
     2221 tatgtaaaga tttatttgga cctgagcagg ataaggaaaa cttcttggta tttgattatg
     2281 gggataattt tgattatttt cgtgcagatc caagagatgg agagggtcgt cacattgttt
     2341 cgttgactca gcgtttattt aatatcaaag tggacttgat tcgagaactt cagggactcc
     2401 aataccaaga agatcagttt gcgagagcat accgtcagca gcttgtctcg gaacttcaag
     2461 gtcgtataga gagcttaaat gagttggact tcagggttcg tatggtttta gatacagttt
     2521 atagctatag gaaattggaa agttggcaga atctaactgc tgttacaagt gaaaccattc
     2581 aaaaaaatct ctctccgctt ttatttgatg aagataaaga agatgagatg gcgaggagat
     2641 ttgatttgtg gttgcttcat attcagttgg ggcaactgac agctaaatct tccactgttc
     2701 atatttccca agtgatgaag acggctagag ctctttctgc tattggcaat atcccgcagg
     2761 tttttgagca ggctgaaatt atcaggaaag tacaggagcc tgaattttgg aaagaagtta
     2821 acttgtctga tttggaaaaa attcgtcttg ctattcgaga tttattacag tttttggata
     2881 aaacagaccg taaaccctac tatgttaact ttgaagatcg tatactctcc actgttcacg
     2941 agaccacagc atttttgcag gtcaacgatc ttcggtctta caatgaaaaa gttgagcatt
     3001 atttgaaaac tcatctggat gaggagtcca tttctaagct ataccataat aaaaagttga
     3061 catctgatga tatgcttgca cttgaaaaat tgctctggga aaaattaggt agtaaagcag
     3121 actaccaaag tcattatgaa aataaggcaa ttccgagatt ggttcgtgag attattggct
     3181 tagatagaga gtctgccaat cgtatttttt ctaaattttt gtcggatgag aatcttaatg
     3241 ccaggcagat ttcatttgta aaattgattg tagactacat tgtagaaaat ggttttttag
     3301 agacgaaagt gttaacgcaa gagccgttta aatcttatgg ttctgttcaa ctactcttcc
     3361 aacaccaact accagtactt cgtaatattg ttcaaatcat tgaacttatc aataatcgag
     3421 ctggagaagc ggcttaaatt ctaaagtgat tgccatgctg agactcattt aaaattaaaa
     3481 agagtagaaa tttatgctat atatgagaag ttttattagg aagaatgtca tcgttttcct
     3541 agaatacagt atcagttgtt aagtggttga taaatttcaa agtagatact tgtaccacga
     3601 tgtttgttga tcgagttatt aacaaaagag ctactttgat tttaaagaaa tagaaaacaa
     3661 aaagccgagc aagaattcaa ttgcaggaga aaatgaaata atactcaatg aaaatcaaag
     3721 agcaaactag gaaactagct gcaggctgct caaaacactg ttttgaggtt gcagatggaa
     3781 gctgacgcgg attgaagaga ttttcgaaga gtataaatct tcctaggata aagcaaaacg
     3841 catagtatca agggttttca acacttgata ctatgcgttt tctgatgtta aagactttct
     3901 accaggtttt ttaaaagcat aattgttagt tgtagtcatt tattattctt caaagaaaaa
     3961 tggtggggcg aattttttca gttcttcaaa gcacttttga gcagtatctg catcttcaca
     4021 gatgataaga cagacatcat taccacaaag ggtagcgata gcgtcaggga agctcaaagt
     4081 atcaatgata gaaccaaagg attgagccag tccaggaagg gtttttagta ggacttggtg
     4141 ttgaactggg cgcatccaga caagggcgtc ttccatgtag agttcgagac gtttttccca
     4201 ttttgagatg gaaccattgt taagaacata ataagcgcta tcttcttcgc ggacttttga
     4261 taggttcata tttttgatgt cgcgtgagag ggttgcctgg gttacttgaa tgtcgttctc
     4321 agcaagaagg gcttgcaact cagcctgtgt atgaatcttg ttttttgtga taagagcgcg
     4381 tataagttgg tggcggtgtt ctgatttatt cataataatg taactccttt tagcaaggta
     4441 aggtaagcat ggactgagcg aggtcgacag tcaagtggta gtctgtattg tcacggatgg
     4501 tgatttcaaa gtcagtagta tagaggacta aacggagagt gtctccttct tttagcttgt
     4561 aaatagttgg ctgcagttca aattgaacgt ccatccattc atctgcagta atatcctcta
     4621 ctaacagtaa atcatttcta ttttgtaaat taaggtaacc ttttgtcacg actcgttgtg
     4681 cctctggtct aaatggcaat tcacagagat tttccaacat gtgatagcga ccgttgtcaa
     4741 tggttctagc acttaaaata gctggataag gttgtaggta tttcttttgc ccaaattcta
     4801 gcagttgggc agataagagc cccttgtttg tactggattt gatacgaaga ttgagctgag
     4861 cgcgaccgtt taggtggaga tctttagtca caggaaggtt aatagtaatc tgattggctt
     4921 tcccttgata gagctctgta ttgaaggttt ggtatgtctt accatagcgc tcaaaatcct
     4981 tatctgggta ctggttttga atagcttgct cttcttgacc aagtgagaag gtttcacagt
     5041 tttcttgccc accgaagtta tcaagtgata accaagtctg tggagctgta ttgtcctgcc
     5101 agataacagt aggaagttga aagtctgttt cctgtcctag taatttcttg gtcaataagg
     5161 catttatgga ctcacggaag tcaattgatt gccaattgtt catgtaaaca tgggcaccat
     5221 tatggaaaaa gagatgcttg tgtatatgag taggaagagc atggaacatc tggtaaacat
     5281 gaagtggttt gacattccaa tcctgagaac catgagtaaa gacaacctct gcctttactt
     5341 tatgggcatt gagcagataa ttgcggtcat gccaaaactg attgtagtcc ccagtttttc
     5401 ggtctagctg agctttcact ttttctaagt cagcttggtg agcttcatta ccacggatat
     5461 agtcgccagc taagagatta cgagaatagg ttaactcagc aagggagtca aagtcctcac
     5521 ctggataacc acctgggcta gtcaccagac cgttttcacg gtagtagttg taccatgatg
     5581 aaattcctgc ctcggcaatg ataacttcta aaccatcgac tcctgtagtc gcaagaccat
     5641 tggacatggt acctagatag gaaagtcctg ttgtagcaac ttttccgttt gaccaatcag
     5701 ccttgacttg acgctggcgc gtgtgatcag taaaggcacg gcaacggccg ttaagccaat
     5761 cgatgacatt tttataagcc tcgatttgct ggtagtctcc attagtcatg aaacctgtcg
     5821 agtctttggt accaacacct gagacataga gattggcaaa gcctctcgga aggaagtagt
     5881 cgtttagtgt atagctagag ttgatgtgag ttagcttttc ctcagcctct gctataagct
     5941 cagctttacc ttggggttgg acgagattta gttgaggttt ctctagctca atcttgtgag
     6001 gaagcttaac ctcaagctcg ccctccatct tgtagagagc cttgtcacta gccttgtcat
     6061 tggttccctg atgataaggg ctggctgtca tgatggcagg gatttttcca tcaaaacgag
     6121 ggcgaataat gctaaccttt actaggtctg atagcccttt ttggtcagta tcgacacgag
     6181 actcaacgta aacgacttca cgaatgacat cctggttaga aaaagtagcc aaactcttgc
     6241 cgttaaagta gtggtagtca ttatcctccg gaataagacc atcactaaca agttggtcga
     6301 taagagtatt tccttttttg gtgcgagtat tgagtaactg atagagattt tcaatcaagt
     6361 caccatatat aatgggaaat ccagtttctt tacgaaaaac gtcactatct tcgaagtcaa
     6421 ccaaataaga aaagcctaaa agttgaaaag caacagtata aaaaatatct gctgtcagtt
     6481 catcttctga ttgaaaaaat gtcagcaggt ctgttttttt atcagctgct aggatagaaa
     6541 gtgggtagtt ggtgtcttga taagtgaaaa agaaacgacg taaaaaggtt tcaagtgagt
     6601 ctttgtgatt ggctgtattt tgtaaatcaa agccacattt ttttagttca gataagacat
     6661 tttcttttgg aaaattgata taactatatt gattaaaacg catagaacct ccatatagaa
     6721 tgacagttaa ggttattata tcaaaaaaaa agcagaaagg gaattgttaa cttcaaaagg
     6781 aaataatcca ataaaaatga ataaagt
//
LOCUS       DAVLHC010000078         6416 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.079, whole genome shotgun sequence.
ACCESSION   DAVLHC010000078 DAVLHC010000000
VERSION     DAVLHC010000078.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 6416)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6416)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6416
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.079"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(93..389)
                     /locus_tag="VXE25_001987"
     CDS             complement(93..389)
                     /locus_tag="VXE25_001987"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000450185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="HEV0772388.1"
                     /translation="METSISMADFYGKYQNENLELIDVREAHEFQAGHAPGAKNLPLS
                     TLEQGYKELKPDHEYYVICQGGVRSASTCQFLSSQGLTVTNVEGGMNAWPGQVE"
     gene            complement(379..540)
                     /locus_tag="VXE25_001988"
     CDS             complement(379..540)
                     /locus_tag="VXE25_001988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014932007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(FAD)-dependent dehydrogenase"
                     /protein_id="HEV0772389.1"
                     /translation="MDKKQAYIVSCHSGLRSYIAEPILKQAGFTAQNLDGAYSLYKMV
                     NPEGVEYGN"
     gene            610..1374
                     /locus_tag="VXE25_001989"
     CDS             610..1374
                     /locus_tag="VXE25_001989"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside phosphorylase"
                     /protein_id="HEV0772390.1"
                     /translation="MIQKHAIPILEFDDNPQAVIMPNHEGLDLQLPKKCVYAFLGEEI
                     DRYAREVGADCVGEFVSATKTYPVYVINYKGEEVCLAQAPVGSAPAAQFMDWLIGYGV
                     EQIISTGTCGVLADIEENAFLVPVRALRDEGASYHYVAPCRYMEMQPEAIAAIEEVLE
                     DRGIPYEEVMTWTTDGFYRETAEKVAYRKEEGCAVVEMECSALAAVAQLRGVLWGELL
                     FTADSLADLDQYDSRDWGSEAFNKALELSLASVHHL"
     gene            complement(1614..1766)
                     /locus_tag="VXE25_001990"
     CDS             complement(1614..1766)
                     /locus_tag="VXE25_001990"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772391.1"
                     /translation="MKIKASIRKLVTGCSKHCFEVVDRTDEVSSKHCFEVADRTDEVS
                     NISTAR"
     gene            1984..3363
                     /locus_tag="VXE25_001991"
     CDS             1984..3363
                     /locus_tag="VXE25_001991"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000897732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TrkH family potassium uptake protein"
                     /protein_id="HEV0772392.1"
                     /translation="MLFKLSKEKIELGLSRLSPARRIFLSFALVILLGSLLLSLPFVQ
                     VESSRATYFDHLFTAVSAVCVTGLSTLPVAHTYNIWGQIICLLLIQIGGLGLMTFIGV
                     FYIQSKQKLSLRSRATIQDSFSYGETRSLRKFVYSIFLTTFLVESLGAILLSFRLIPQ
                     LGWGRGLFSSIFLAISAFCNAGFDNLGSTSLFAFQTDLLVNLVIAGLIITGGLGFMVW
                     FDLAGHVGRKKKGRLHFHTKLVLLLTIGLLLFGTATTLFLEWNNAGTIGNLPVADKVL
                     VSFFQTVTMRTAGFSTIDYTQAHPVTLLIYILQMFLGGAPGGTAGGLKITTFFVLLVF
                     ARSELLGLPHANVARRTIAPRTVQKSFSVFIIFLMSFLIGLILLGITAKGNPPFIHLV
                     FETISALSTVGVTANLTPDLGKLALSVIMPLMFMGRIGPLTLFVSLADYHPEKKDMIH
                     YMKADISIG"
     gene            3377..4042
                     /locus_tag="VXE25_001992"
     CDS             3377..4042
                     /locus_tag="VXE25_001992"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001283913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TrkA family potassium uptake protein"
                     /protein_id="HEV0772393.1"
                     /translation="MSDRTIGILGLGIFGSSVLAALAKQDMNIIAIDDHAERINQFEP
                     VLARGVIGDITDEELLRSAGIDTCDTVVVATGENLESSVLAVMHCKSLGVPTVIAKVK
                     SQTAKKVLEKIGADSVISPEYEMGQSLAQTILFHNSVDVFQLDKNVSIVEMKIPQSWA
                     GQSLSKLDLRGKYNLNILGFREQENSPLDVEFGPDDLLKADTYILAVINNQYLDTLVA
                     LNS"
     gene            4177..4251
                     /locus_tag="VXE25_001993"
                     /pseudo
     CDS             4177..4251
                     /locus_tag="VXE25_001993"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829418.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            4397..4936
                     /locus_tag="VXE25_001994"
     CDS             4397..4936
                     /locus_tag="VXE25_001994"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HEV0772394.1"
                     /translation="MKLLSIAISSYNAAAYLHYCVESLVIGGEQVGILIINDGSQDQT
                     QEIAECLASKYPNIVRAIYQENKGHGGAVNRGLAEASGRYFKVVDSDDWVDPRAYLKI
                     LETLQELESKGQEVDVFVTNFVYEKEGQSRKKSMSYDSVLPVRQIFGWDQVGNFSKGQ
                     YIMMHSLIYRTDLLRASQF"
     gene            5036..5413
                     /locus_tag="VXE25_001995"
     CDS             5036..5413
                     /locus_tag="VXE25_001995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000580215.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase family 2"
                     /protein_id="HEV0772395.1"
                     /translation="MIGREDQSVNEQVMIKCIDQQLKVNRLLVDQLDLSQVSHPKMRE
                     YLLNHIEITTVISSTLLNRSETAEHLAKKRQLWTYIQQENPKVFQAIRKTMLSRLTKH
                     SVLPDRKLSNVVYQITKSVYGFN"
     gene            5529..>6416
                     /gene="pavB"
                     /locus_tag="VXE25_001996"
     CDS             5529..>6416
                     /gene="pavB"
                     /locus_tag="VXE25_001996"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000671383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fibronectin-binding SSURE repeat adhesin PavB"
                     /protein_id="HEV0772396.1"
                     /translation="MKFNPNQRYTRWSIRRLSVGVASVVVASGFFVLVGQPSSVRADG
                     LNPTPGQVLPEETSGTKEGDLSEKPGDTVLTQAKPEGVTGNTNSLPTPTERTEVSEET
                     NSSSLDTLFEKDEEAQENPELTDALKETVDTADVDGTQASPAETTPEQVKGGVKENTK
                     DSIDVPAAYLEKAEGKGPFTAGVNQVIPYELFAGDGMLTRLLLKASDNAPWSDNGTAK
                     NPALPPLEGLTKGKYFYEVDLNGNTVGKQGQALIDQLRANGTQTYKATVKVYGNKDGK
                     ADLTNLVATKNVDININGLV"
BASE COUNT         1733 a         1223 c         1486 g         1974 t
ORIGIN      
        1 gcctgcggct aacttcctag tttgcacttt aattttcatt gagtattact tcatcttctc
       61 atgaaattga gtttttgccc agctcctctt gattattcta cttgaccggg ccaagcattc
      121 ataccacctt ctacgttggt aacggtgagg ccttgggagc tgagaaattg gcaggtagat
      181 gcagagcgga ctcctccttg acaaatgaca tagtattcat ggtcaggttt gagttctttg
      241 tagccttgct ctaaggtact taatggaaga tttttggcac ctggtgcatg tcctgcttgg
      301 aattcatgtg cttcacggac atcgataagt tctagatttt cattttggta ttttccataa
      361 aagtcagcca tgctgatact agtttccata ttctactcct tctgggttaa ccattttgta
      421 tagtgaataa gcgccgtcaa ggttttgggc ggtaaatcct gcttgcttga ggataggctc
      481 tgcgatatag ctgcgcaaac cactgtggca gctgacgatg taggcttgtt ttttgtccag
      541 ttcatcagct tcctccttga cactttgtca gtttttgata caatagtaca aaattagagg
      601 aggcaggcta tgattcagaa acatgcgatt cctattttag agtttgatga caatcctcag
      661 gcggttatca tgcccaatca cgaggggctg gacttgcagt tgccaaagaa gtgtgtttat
      721 gcatttttag gtgaggagat tgaccgctat gcaagggaag taggggcgga ttgtgtcggc
      781 gaattcgttt ctgctaccaa gacctatcca gtctatgtca tcaactacaa gggtgaggag
      841 gtctgtctgg ctcaggctcc tgttggctcc gctccagcag cccagtttat ggattggttg
      901 attggctatg gtgtggagca gattatctct actgggacct gtggtgtcct agctgatata
      961 gaggaaaatg cctttctagt ccctgttcgc gctttgcgag atgagggagc cagttaccac
     1021 tatgtggcac cttgtcgtta tatggaaatg cagccagagg ctattgctgc tattgaggaa
     1081 gttttggaag acagagggat tccttatgaa gaagtcatga cctggacgac agacggtttt
     1141 taccgagaaa cggctgaaaa ggtggcttat cgtaaggaag aaggctgtgc tgttgtggag
     1201 atggagtgtt ctgctcttgc ggcagtagct caattgcgtg gggttctctg gggtgaattg
     1261 ttgttcacag cagattctct agcggacttg gaccagtacg acagtcgtga ctggggctcg
     1321 gaagctttta ataaggcgct agaactgagt ttagcaagtg ttcaccacct ttagttgtac
     1381 tggcaaagga tttgttttat cataaaatgt ctagctcata cttttcaaaa atatgtttaa
     1441 acgaggtcac cttcctcttg tcctaggcat gttgaggttg ggaaaaatct ttaaaatcag
     1501 aaaaacgtat catatcaggt gatgaaaact ttgatactat gcgttttatg ttggtaagat
     1561 ttagagtgag atgaaatgat actcttcgaa aatcttttca aaccaggtca gcttcacctt
     1621 gccgtagata tgttactgac ttcgtcagtt ctatctgcaa cctcaaaaca gtgttttgag
     1681 ctgacttcgt cagttctatc cacaacctca aaacagtgtt ttgagcaacc tgtgactagc
     1741 tttctaatcg atgccttgat tttcattgcc tataatcaaa aagagaaatt ttctcctgaa
     1801 aagcatatag agtagctggc gttaaaagct cctgtcttgc ttttttgacc tatagtcaca
     1861 tctatcaagt attgttcttg cctaagctat caataaaaag gtggcatttt ttaggcttgg
     1921 tgttagtgaa ttttgcctta tcctatctaa gtcatttcga gctttttatg gtacaatgga
     1981 aacatgttat tcaaattatc taaggaaaaa atagagctag gcttatctcg tttatcgcca
     2041 gcccgtcgta tttttttgag ttttgccttg gtcattttac taggctctct tcttttgagc
     2101 ttgccctttg tccaagttga aagctcacga gcgacttatt ttgatcatct tttcactgct
     2161 gtctctgcag tctgtgtgac aggtctctca acccttccag tagctcacac ctataatatc
     2221 tggggccaaa taatctgttt gctcttgatt cagatcggtg gtctagggct catgactttt
     2281 attggggttt tctatatcca gagcaagcaa aagcttagtc ttcgtagccg tgcaactatt
     2341 caggatagtt ttagttatgg agaaactcga tctttgagaa agtttgtcta ttctattttt
     2401 ctcacgacct ttttggttga gagcttggga gctattttgc ttagttttcg ccttattcct
     2461 caacttggct ggggacgtgg tctttttagt tccatttttc tagcgatctc agccttctgt
     2521 aatgccggtt ttgataattt agggagcacc agtttatttg cttttcagac cgatttactg
     2581 gtcaatctgg tgattgcagg cttgattatt acaggcggcc ttggttttat ggtctggttt
     2641 gatttggctg gtcatgtagg aagaaagaaa aaaggacgtc tgcactttca tacgaagctt
     2701 gtactattat tgactatagg tttgttgtta tttggaacag caactactct ctttcttgag
     2761 tggaacaatg ctggaacgat tggcaatctc cctgttgccg ataaggtttt agttagcttt
     2821 tttcaaacag tgacgatgcg aacagctggc ttttctacga tagattatac tcaggctcat
     2881 cctgtgactc ttttgattta tatcttacag atgtttctag gtggggcacc tggaggaaca
     2941 gctgggggac tcaagattac gacatttttt gtcctcttgg tctttgcacg aagtgagctt
     3001 ctaggcttgc ctcatgccaa tgttgcgaga cgaacgatcg cgccgcgaac ggttcaaaaa
     3061 tcctttagtg tctttattat ctttttgatg agcttcttga taggattgat tctgctaggg
     3121 ataacagcca aaggcaatcc tccctttatc cacctcgtat ttgaaaccat ttcagctctt
     3181 agtacagttg gtgtaacggc aaatctgact cctgaccttg ggaaattggc tctcagtgtt
     3241 atcatgccac ttatgtttat gggacgaatt ggtcccttga ccttgtttgt tagcttggca
     3301 gattaccatc cagaaaagaa agatatgatt cactatatga aagcagatat tagtattggt
     3361 taagaaagga aagagcatgt cagatcgtac gattggaatt ttgggcttgg gaatttttgg
     3421 gagcagtgtc ctagctgccc tagccaagca ggatatgaat attatcgcta ttgatgacca
     3481 cgcagagcgc atcaatcagt ttgagccagt tttggcgcgt ggagtgattg gtgacatcac
     3541 agatgaagaa ttattgagat cagcagggat tgatacctgc gataccgttg tagtcgcgac
     3601 aggtgaaaat ctggagtcga gtgtgcttgc ggttatgcac tgtaagagtt tgggggtacc
     3661 gactgttatt gctaaggtca aaagtcagac cgctaagaaa gtgctagaaa agattggagc
     3721 tgactcggtt atctcgccag agtatgaaat ggggcagtct ctagcacaga ccattctttt
     3781 ccataatagt gttgatgtct ttcagttgga taaaaatgtg tctatcgtgg agatgaaaat
     3841 tcctcagtct tgggcaggtc aaagtctgag taaattagac ctccgtggca aatacaatct
     3901 gaatattttg ggtttccgag agcaggaaaa ttccccattg gatgttgaat ttggaccaga
     3961 tgacctcttg aaagcagata cctatatttt ggcagtcatc aacaaccagt atttggatac
     4021 cctagtagca ttgaattcgt aaagagggat gacccctctt ttttgatgcc caagatggca
     4081 aatagagaca gaagcccctt gtcttctagt aaaagttctt caaaggctgg actttatggt
     4141 aaaatagaaa gaagtgacaa gagagagtaa tactcaatga aaatcaaaga tcaaactagg
     4201 aaactagcta cgggctgctc aaaacagtgt tttgaggttg tggatagaac tgacgaagtc
     4261 agctcaaaac agtgttttga ggttgcagat agaactgacg aagtcagtaa catctatacg
     4321 gcaaggcgac gttgacgcgg tttgaagaga ttttcgaaga gtataagaaa aaatcagtcc
     4381 cctaaaggag cagattatga agttattgtc tatcgccatt tctagctata atgcagcagc
     4441 ctatcttcat tactgtgtgg agtcgctagt gattggtggt gagcaagttg ggattttgat
     4501 tatcaatgac gggtctcagg atcagactca ggaaatcgct gagtgtttag ctagcaagta
     4561 tcctaatatc gttagagcca tctatcagga aaataaaggc catggcggtg cggtcaatcg
     4621 tggcttggca gaggcttctg ggcgctattt taaagtagtt gacagtgatg actgggtgga
     4681 tcctcgtgcc tacttgaaaa ttcttgaaac cttgcaggaa cttgagagca aaggtcaaga
     4741 ggtggatgtc tttgtgacca attttgtcta tgaaaaggaa gggcagtctc gtaagaagag
     4801 tatgagttac gattcagtct tgcctgttcg gcagattttt ggctgggacc aggtcggaaa
     4861 tttctccaaa ggccagtata tcatgatgca ctcgctgatt tatcggacag atttgttgcg
     4921 tgctagccag ttctaactgc ctgaacatac tttttatgtc gataatctct ttgtctttac
     4981 gccccttcag caggtcaaga ccaggtacta tctgcctgtc gatttctatc gttatttgat
     5041 tgggcgtgag gaccagtctg tcaatgagca agtgatgatt aagtgcattg accagcaact
     5101 caaggtcaat cgactcttgg tagaccagct tgatttgtcc caagtgagtc atcctaaaat
     5161 gcgagaatat ctgctgaatc atattgaaat cacgacggtg atttccagta ccctgctcaa
     5221 ccgatctgaa acagcggagc atctggcaaa aaaacgccaa ttgtggacct atattcagca
     5281 ggaaaatcca aaagtctttc aggctattcg taagaccatg ttgagccgtt tgaccaaaca
     5341 ttctgtcttg ccagatcgca aactgtccaa tgtcgtctat caaatcacca aatctgttta
     5401 tggatttaat taatataagt gttttataag agggatttaa gaaaaatttt aactttttct
     5461 tagtcctttt taatttcagg agattatact agagtcatca aataaagaaa gactctaagg
     5521 agaatcctat gaaattcaat ccaaatcaaa gatatactcg ttggtctatt cgccgtctca
     5581 gtgtcggtgt tgcctcagtt gttgtggcta gtggcttctt tgtcctagtt ggtcagccaa
     5641 gttctgtacg tgccgatggg ctcaatccga ccccaggtca agtcttacct gaagagacat
     5701 cgggaacgaa agagggtgac ttatcagaaa aaccaggaga caccgttctc actcaagcga
     5761 aacctgaggg cgttactgga aatacgaatt cacttccgac acctacagaa agaactgaag
     5821 tgagcgagga aacaaactct tctagtctgg atacactttt tgaaaaagat gaagaagctc
     5881 aagaaaatcc agagctaaca gatgccttaa aagaaactgt agatacagct gatgtggatg
     5941 ggacacaagc aagtccagca gaaactactc ctgaacaagt aaaaggtgga gtgaaagaaa
     6001 atacaaaaga cagcatcgat gttcctgctg cttatcttga aaaagctgaa gggaaaggtc
     6061 ctttcactgc cggtgtaaac caagtaattc cttatgaact attcgctggt gatggtatgt
     6121 taactcgtct attactaaaa gcttcggata atgctccttg gtctgacaat ggtactgcta
     6181 aaaatcctgc tttacctcct cttgaaggat taacaaaagg gaaatacttc tatgaagtag
     6241 acttaaatgg caatactgtt ggtaaacaag gtcaagcttt aattgatcaa cttcgcgcta
     6301 atggtactca aacttataaa gctactgtta aagtttacgg aaataaagac ggtaaagctg
     6361 acttgactaa tctagttgct actaaaaatg tagacatcaa catcaatgga ttagtt
//
LOCUS       DAVLHC010000079         6137 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.080, whole genome shotgun sequence.
ACCESSION   DAVLHC010000079 DAVLHC010000000
VERSION     DAVLHC010000079.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 6137)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6137)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6137
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.080"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            159..467
                     /locus_tag="VXE25_001997"
                     /pseudo
     CDS             159..467
                     /locus_tag="VXE25_001997"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000996568.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-mannose 4,6-dehydratase"
     gene            631..1290
                     /locus_tag="VXE25_001998"
     CDS             631..1290
                     /locus_tag="VXE25_001998"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000793810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1868 domain-containing protein"
                     /protein_id="HEV0772397.1"
                     /translation="MKNLTKIKFKENGEFNHFPGNTVVANLYTKQDLMEVVDIIQSRY
                     RELPFIDKFTLTPRNSIHMTVIELLCHENRETEFWSSNLPLDTPLQEIHDYFAKQLEI
                     FPLLDEEIHMRITEMGKQNILVEPADEASAKRLEEIRTYVSEKAGVCFPNHDRYQFHI
                     SIGYLRIPLTEEEEEEFTKVRAELTEILLEKIPTITVNRIDYTVFEDMRQFVPYHEKF
                     K"
     gene            1315..2382
                     /locus_tag="VXE25_001999"
     CDS             1315..2382
                     /locus_tag="VXE25_001999"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000738359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HEV0772398.1"
                     /translation="MKKMKVWSTVLATGVALTTLAACSGGSNSTTASSSEEKADKSQE
                     LVIYSNSVSNGRGDWLTAKAKEAGFNIKMVDIAGAQLADRVIAEKNNAVADMVFGIGA
                     VDSNKIRDQKLLVQYKPKWLDKIDQSLSDKDNYYNPVIVQPLVLIGAPDVKEMPKDWT
                     ELGSKYKGKYSIYGLQGGTGRAILASILVRYLDEKGDLGVSEKGWEVAKEYFANAYTL
                     QKGESSVVKALDKESPIQYGMIWGSGALIGQKEQNVEFKVMTPEIGVPFVTEQTMVLS
                     TSKKQALAKEFIDWFGQSEIQVEYSKKFGSIPANKDALKELPEDTKKFVDQVKPQNID
                     WEAVGKHLDEWVEKAELEYVK"
     gene            2486..3496
                     /locus_tag="VXE25_002000"
     CDS             2486..3496
                     /locus_tag="VXE25_002000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0772399.1"
                     /translation="MIKFDNIQIKYGDFVAIDNLNLDIHEGEFFTFLGPSGCGKSTTL
                     RALVGFLDPSSGSIEVNGTDVTHLEPEKRGIGIVFQSYALFPTMTVFDNIAFGLKVKK
                     VAPDVIKAKVSAVAAKIKISDQQLQRNVSELSGGQQQRVALARALVLEPKILCLDEPL
                     SNLDAKLRVDLRKELKRLQKELGITTLYVTHDQEEALTLSDRIAVFNNGYIEQVGTPV
                     EIYHNSQTEFVCDFIGDINVLTDETVHEVLLKNTSVFLEDKKGYIRLEKVRFNRETEQ
                     DFILKGTIIDVEFSGVTIHYTIKVSESQILNVTSIDSQAAIRSVGESAELFIIPSDVL
                     QF"
     gene            3508..5199
                     /locus_tag="VXE25_002001"
     CDS             3508..5199
                     /locus_tag="VXE25_002001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HEV0772400.1"
                     /translation="MRHKLNLKDWLIRLGLIWFLVTFIIYPNFDLVVNVFVKGGEFSL
                     DAVHRVLKSQRALQSIMNSFKLAFSLIITVNVVGILCVLFTEYFDIKGAKILKLGYMT
                     SLIYGGVVLATGYKFVYGPYGLITKFLQNVIPSLDSNWFIGYGAVLFIMTFSGTANHT
                     LFLTNTIRSVDYHTIEAARNMGAKPFTVFRKVVLPTLIPTLFALTIMVFLSGLSAVAA
                     PMIVGGKEFQTINPMIITFAGMGNSRDLAALLAIILGIATTILLTIMNKIEKGGNYIS
                     ISKTKAPLKKQKIASKPWNIIAHIVAYGLFTVFMLPLIFIVLYSFTDPVAIQTGNLTL
                     SNFTLENYRLFFSNSAAFSPFLVSFIYSIIAATTATILAVVFARVVRKHKSRFDFLFE
                     YGALLPWLLPSTLLAVSLLFTFNQPQFLVLNQILVGSLVILLIAYIVVKIPFSYRMVR
                     AILFSVDDEMEDAARSMGASPFYTMMKVIIPFILPVVLSVIALNFNSLLTDFDLSVFL
                     YHPLAQPLGITIRSAGDETATSNAQALVFVYTIVLMIISGTVLYFTQRPGRKVRK"
     gene            5202..5912
                     /locus_tag="VXE25_002002"
     CDS             5202..5912
                     /locus_tag="VXE25_002002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000127555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MgtC/SapB family protein"
                     /protein_id="HEV0772401.1"
                     /translation="MTATSLGLSNIEIVVRIVLSVVIGSIIGLERGSKSQPAGIRTYS
                     IVCLAACLIMMTNEYVSYKFGTGDPTRLGAQVISGVGFLGAGTILITDKKKITGLTTA
                     AGIWASAGIGLAIGVGFYEGALLVAISVWGVISMFQPLKKYLQNRSKMIELYIVVKST
                     EAYNRVLVYCAENGIRMTDSRTAFGDVNSDRIEYFDVPDKKIASFITLELSGRFEHLR
                     LMEEIANIVGVIYVEEIS"
BASE COUNT         2054 a          845 c         1169 g         2069 t
ORIGIN      
        1 actatattat cgcttaccaa tatttgctaa actttcagaa aaaaagttgg agtatatgat
       61 gctaggtgac tgcgtcatgt tagtaaacga aatggaaata actgatcata gagtagataa
      121 cttatttgaa aaagggaaaa atgagataaa agattcaagt agtagattta gcaataggac
      181 atataaaagc tttagaaaaa gtatctgaaa aaacagatgt ttatatctat aacctaggct
      241 cgggagaagg cactagtgta ttacaacttg taaatacatt tgaaagtgtt aataagatcc
      301 ctattcctta taaaatagtt ccaagacgtt caggagacgt tgcaacttat tatgcaaatg
      361 cagacaaagc atataaggaa ttaaattgga ggacaacaaa atcgattgaa gacatgtgta
      421 gagatacatg gaattggcaa tcaaaaaatc ccaatggcta taattgatga tactgtctat
      481 atgagtgctg tattttggaa aaattactta accttttaat gaaagataaa ttaaaaaaaa
      541 tgtttgacag cgcttgacaa aggaaacggt ttcattgtat aatgtaaaca caatgacacc
      601 gatgtcaaat ataaaaaaga aggtctttat atgaaaaact taacaaaaat taagttcaaa
      661 gaaaatgggg aatttaatca tttccctggg aatacagttg tagcaaatct ttatactaaa
      721 caagatttga tggaagttgt tgatattatt caatcacgtt atagagaatt accatttatc
      781 gataagttta ctttaactcc aaggaattct attcacatga ctgtaattga attgttgtgc
      841 catgaaaatc gtgaaacgga gttttggagc agtaatcttc ctctagatac acctttacag
      901 gaaatacatg attactttgc taaacaactt gaaatttttc cattgttgga tgaagaaatt
      961 catatgcgta taactgaaat gggaaaacaa aacatactag ttgaacctgc agatgaagct
     1021 tctgcaaaga gattagaaga aattcgtact tatgtctcag aaaaagcagg tgtttgtttc
     1081 cctaatcatg atagatatca attccatatt tcaattgggt atcttcggat tcctctaacc
     1141 gaagaggagg aagaagagtt tactaaagtc agagcagaat taactgaaat tttattagag
     1201 aagattccaa ctattactgt aaaccgtatt gactatactg tatttgaaga tatgagacaa
     1261 tttgttccat atcacgaaaa atttaaataa aataataaaa aaggagaact tatcatgaaa
     1321 aaaatgaaag tttggtctac tgtacttgca acgggagttg ctcttactac acttgctgct
     1381 tgctctggag gttcaaattc tacgactgct tcttcatctg aagaaaaagc tgataaaagt
     1441 caagaattag ttatctattc gaactcagtc tcaaatggtc gtggtgattg gttaactgct
     1501 aaagcaaaag aagctggttt taatataaaa atggttgata tcgctggcgc tcaattagca
     1561 gaccgtgtta ttgctgagaa gaataatgca gttgcagata tggtatttgg aattggtgct
     1621 gttgattcaa ataaaattag agatcaaaaa ttactagtac agtacaagcc taaatggtta
     1681 gataaaattg atcaatcttt atcagataaa gataattatt ataatcctgt gattgttcaa
     1741 ccattagttt taattggggc gcctgatgta aaagaaatgc ctaaagattg gactgaatta
     1801 ggtagtaagt ataaaggtaa atattcaatt tatggtcttc aaggtggtac aggacgggca
     1861 attctagcaa gtatcttagt tcgttacctt gatgaaaaag gagatttagg cgtatcagaa
     1921 aaaggatggg aagttgcaaa agaatacttt gcaaatgcct atactcttca aaaaggtgaa
     1981 agctcagttg ttaaagcgtt agataaagaa agcccaattc aatacggtat gatctggggt
     2041 tctggagcgt taattggaca aaaagaacaa aatgttgaat tcaaagttat gactcctgag
     2101 attggtgtac catttgtaac tgaacaaact atggttttaa gcactagtaa aaaacaagcg
     2161 ttagctaaag aatttattga ttggtttggt caatcagaaa ttcaagtaga atatagtaaa
     2221 aaatttggat ctattcctgc caataaagat gccctaaaag agttacctga agatacgaaa
     2281 aaatttgttg atcaagtgaa accacaaaat attgactggg aagctgttgg aaagcatttg
     2341 gatgaatggg tagaaaaagc tgaattagaa tacgtaaaat aagaaataag agttattttt
     2401 tatgtccaag tctctctatt atttctaaat ttaaggaaga aataaagaga ggcttttggt
     2461 tttagtaata gagggagtta gtgagatgat taaatttgat aatattcaaa ttaaatatgg
     2521 tgattttgtt gcaattgata atctgaattt agatatacat gaaggggaat tctttacatt
     2581 tcttgggcct tcaggatgtg gtaaatcaac tactttgaga gcattggtag gttttttaga
     2641 tccatcatca ggaagtattg aagttaatgg aacagatgtc actcatttgg aacctgaaaa
     2701 gcgtggaatt ggtattgtat ttcaatctta tgcgctattt ccaactatga ctgtttttga
     2761 taatattgca tttggtttaa aagttaagaa ggtagctcca gatgttatta aagctaaagt
     2821 atcagcagtg gcagcaaaaa ttaagatctc tgatcaacag ttacagcgta atgtatcaga
     2881 attatctggg ggtcaacaac aaagggtagc attggctcgt gctctggttc ttgaacctaa
     2941 aattctttgt ctagatgaac cattgtcaaa ccttgacgca aaattacgtg tagatttgag
     3001 aaaagagttg aaaagacttc aaaaagagtt aggtattact actttatatg ttactcatga
     3061 tcaagaggaa gccttgactt tatctgatag aattgcagtc tttaacaatg gatacatcga
     3121 acaggtcggt acaccagtag agatttatca taattctcaa actgaatttg tatgtgattt
     3181 tattggagat attaatgttt tgaccgatga aacagtccac gaagtattat tgaaaaatac
     3241 aagcgttttc ttagaggata aaaaaggata cattcgatta gagaaagttc gattcaatcg
     3301 tgaaactgaa caagatttta ttctaaaagg gacaattatt gatgttgagt tttctggagt
     3361 tacaattcac tatacaataa aagtttctga aagtcagatt cttaatgtaa caagtattga
     3421 tagtcaggct gctattagat ctgtcggaga aagtgcggaa ttatttatca taccatcaga
     3481 cgttctgcaa ttttaaggag gtgcagtatg cgtcataaat taaatttaaa agattggctt
     3541 attcgtttag ggttaatctg gttcttagta acatttatta tttatccaaa ctttgatcta
     3601 gtagtgaatg tatttgtaaa aggaggagaa ttttcccttg atgctgtaca tcgtgttcta
     3661 aaatctcaga gggcacttca gagtattatg aacagtttta agttagcatt ttcactcatt
     3721 attacagtta atgtcgtagg tattctttgt gttctattta cagagtactt tgatattaaa
     3781 ggtgctaaaa ttttaaaatt aggttatatg acctctttaa tttatggagg agtggtttta
     3841 gcgactggat ataaatttgt ctatggtcct tatggattga ttacaaaatt tttacaaaat
     3901 gttatccctt ctttagactc taactggttt attgggtatg gtgcagtctt attcattatg
     3961 acattttcag gaactgctaa tcatacattg tttttaacaa atacaattcg aagcgttgac
     4021 tatcacacta ttgaggctgc tcgaaatatg ggagcaaaac catttactgt tttccgaaaa
     4081 gtagtgttac caaccttaat tccaactcta tttgcactta ctattatggt ttttcttagt
     4141 ggtttatctg cagtagcagc acccatgatt gttggtggta aagaatttca aactataaat
     4201 ccaatgatta ttacatttgc agggatgggg aattctcgtg atttagctgc cttacttgca
     4261 attattttag gtattgcaac tacaattttg cttactatca tgaataagat agaaaaaggt
     4321 ggaaattata tttctatctc taagactaaa gcgcctctta aaaaacaaaa aattgcgtct
     4381 aagccttgga atatcattgc tcacattgta gcatatggat tgttcacagt tttcatgctt
     4441 ccactaattt ttatagtatt atactcattt acagatccag ttgcaattca aacaggtaac
     4501 ttaacattat caaactttac tttagaaaat tatcgcttat tctttagtaa tagtgcggca
     4561 ttctctccat tcttggtcag ctttatttat tctattattg ctgcgacaac agcaacaatt
     4621 ctcgcagttg tatttgctcg tgttgtcaga aaacataaat ctcgttttga tttcttattt
     4681 gaatatggtg ctctacttcc ttggttacta ccaagtacac ttttagcagt aagtttatta
     4741 tttactttta atcagccaca atttcttgtt ttgaatcaga ttttggtagg tagtttggta
     4801 attctactta ttgcatatat agttgtaaaa atcccatttt cttatagaat ggtacgtgct
     4861 attttattta gtgttgatga tgagatggaa gatgcagcaa gaagtatggg tgcttcacct
     4921 ttttatacta tgatgaaggt tatcattcca tttattttac cggttgttct ctctgttatt
     4981 gctttaaact ttaactcttt attaactgac ttcgacttat ctgtattcct ttaccatccc
     5041 ctagctcaac cattaggtat tacgattcga tctgcaggtg atgaaacagc aacatctaat
     5101 gcacaagctc tggtatttgt ttatacaatt gttctgatga ttatttctgg aacggtatta
     5161 tacttcacac aaagaccggg gcgtaaagta aggaaataat catgacagcc actagtcttg
     5221 ggttatcaaa tattgaaata gttgtcagga ttgttttatc agtagtcatt ggtagtataa
     5281 ttggtttaga gagagggagc aaatcccagc ctgcaggcat ccgaacttat agtattgttt
     5341 gtctagctgc atgtttgatt atgatgacga atgaatacgt atcttataaa tttgggacag
     5401 gagatcctac acgattagga gctcaagtta tatcaggtgt gggttttcta ggcgctggaa
     5461 cgattcttat tacagataaa aagaaaatta caggtctgac aactgcagca ggcatttggg
     5521 cttcggcagg aattggatta gctattggag taggttttta tgagggagct cttttagtag
     5581 ccatttctgt ttggggtgtg atatccatgt tccaaccact aaaaaaatat ctgcaaaatc
     5641 gttctaaaat gattgaattg tatatagtgg ttaaatctac agaagcctat aatcgtgtat
     5701 tggtttattg tgcagaaaat ggtatcagaa tgaccgattc aagaacagcg tttggagatg
     5761 ttaattctga cagaattgaa tactttgatg ttccggacaa aaaaatagcg tcatttatta
     5821 ctctggaatt atcaggtaga tttgaacatc ttcggctgat ggaagaaatt gctaatattg
     5881 taggtgttat ttatgtcgaa gaaattagct gaaatttagt aaacaaaggg acagatgttt
     5941 ttgtcctttt gctttttaga tgttttaatc atctaatttt tgagtagatt tttgctcaga
     6001 ggtttttatg aaagattata aaatcaattt tgatttaggt aaaatagaat attttgataa
     6061 taattgtttg atacaagtat acaaatttat ttctttttat gatatttgtg aaatggtgtt
     6121 tgcctttcat ttacctc
//
LOCUS       DAVLHC010000080         6085 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.081, whole genome shotgun sequence.
ACCESSION   DAVLHC010000080 DAVLHC010000000
VERSION     DAVLHC010000080.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 6085)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6085)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6085
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.081"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            69..311
                     /locus_tag="VXE25_002003"
     CDS             69..311
                     /locus_tag="VXE25_002003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001853822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antitoxin"
                     /protein_id="HEV0772402.1"
                     /translation="MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYD
                     ARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE"
     gene            313..567
                     /locus_tag="VXE25_002004"
     CDS             313..567
                     /locus_tag="VXE25_002004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="HEV0772403.1"
                     /translation="MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKAL
                     VGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHRRDIY"
     gene            614..1309
                     /locus_tag="VXE25_002005"
     CDS             614..1309
                     /locus_tag="VXE25_002005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000731124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="potassium channel family protein"
                     /protein_id="HEV0772404.1"
                     /translation="MKKKWFFADYYDTTIILLALISVILVLLGFAEMTDLDNPPYSII
                     DLVIWGVFVIDYSWRFFITKRKWRFILENIFDLLTILPLNAIFTVFRLGRIFRLARLT
                     KLLKLTRLLRIIGLTGKLERKISRFLRTNGLIYILYVNIFIVLVGSSILSVVEEKSFS
                     DSLWWALVTVTTVGYGDIVPVSLFGKWLAVLLMLVGIGTIGMLTSALTNFFVKDNPDE
                     QIKLDKLKDELSS"
     gene            complement(1646..2632)
                     /locus_tag="VXE25_002006"
     CDS             complement(1646..2632)
                     /locus_tag="VXE25_002006"
                     /EC_number="1.1.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019768616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-lactate dehydrogenase"
                     /protein_id="HEV0772405.1"
                     /translation="MTSTKQHKKVILVGDGAVGSSYAFALVNQGIAQELGIIEIPQLH
                     EKAVGDALDLSHALAFTSPKKIYAAQYSDCADADLVVITAGAPQKPGETRLDLVGKNL
                     AINKSIVTQVVESGFKGIFLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQ
                     ALAEKLDVDARSVHAYIMGEHGDSEFAVWSHANIAGVNLEEFLKDTQNVQEAELIELF
                     EGVRDAAYTIINKKGATYYGIAVALARITKAILDDENAVLPLSVFQEGQYGVENVFIG
                     QPAVVGAHGIVRPVNIPLNDAETQKMQASAKELQAIIDEAWKNPEFQEASKN"
     gene            2826..5294
                     /gene="gyrA"
                     /locus_tag="VXE25_002007"
     CDS             2826..5294
                     /gene="gyrA"
                     /locus_tag="VXE25_002007"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001152996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA gyrase subunit A"
                     /protein_id="HEV0772406.1"
                     /translation="MQDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHR
                     RILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVD
                     GHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPAR
                     FPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTG
                     ALVMGKSGIHKAYETGKGSIVLRSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVR
                     LVQEKRIEGITAVRDESNREGVRFVIEVKRDASANVILNNLFKMTQMQTNFGFNMLAI
                     QNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIR
                     IIRASETDAEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIAD
                     LADILAKPERVSQIIKDELDEVKRKFSDKRRTELMVGQILSLEDEDLIEESDVLITLS
                     NRGYIKRLDQDEFTAQKRGGRGVQGMGVKDDDFVRELVSTSTHDHLLFFTNKGRVYRL
                     KGYEIPEYGRTAKGLPVVNLLKLDEDESIQTVINVESDRSDDAYLFFTTRHGIVKRTS
                     VKEFANIRQNGLKALNLKDEDELINVLLAEGDMDIIIGTKFGYAVRFNQSAVRGMSRI
                     ATGVKGVNLREGDTVVGASLITDQDEVLIITEKGYGKRTVATEYPTKGRGGKGMQTAK
                     ITEKNGLLAGLMTVQGDEDLMIITDTGVMIRTNLANISQTGRATMGVKVMRLDQDAQI
                     VTFTTVAVAEKEEVGTENETEGEA"
     gene            5294..6037
                     /gene="srtA"
                     /locus_tag="VXE25_002008"
     CDS             5294..6037
                     /gene="srtA"
                     /locus_tag="VXE25_002008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000078846.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sortase SrtA"
                     /protein_id="HEV0772407.1"
                     /translation="MSQKNNKKKNKRKNLLTNILAGFLILLSLALIFNTQIRNIFIVW
                     NTNKYQVSQVSKEKLEENQDTEGNFDFDSVKAISSEAVLTSQWNAQKLPVIGGIAIPE
                     LEMNLPIFKGLDNVNLFYGAGTMKREQVMGEGNYSLASHHIFGVDNANKMLFSPLDNA
                     KNGMKIYLTDKNKVYTYEIREVKRVTPDRVDEVDDRDGVNEITLVTCEDLAATERIIV
                     KGDLKETKDYSQTSDEILTAFNQPYKQFY"
BASE COUNT         1921 a         1006 c         1318 g         1840 t
ORIGIN      
        1 tttttatatt gactgaacac ctaaaaagta atacaatggt gttaccatta aaaaagggag
       61 cacaaaagat gactactatt acattaaaag tttctgaagc tgataaaaca tttatgaaag
      121 caatggctaa gtttgaagga gtttcccttt cggaacttat tcgcaccaaa actcttgaag
      181 ccctagaaga tgaatacgat gctcgtgtgg cagatttagc ctatcaagag tatttagaag
      241 acttggaaaa aggagttgaa cccattactt gggaagaaat gatgcatgat ttaggcttga
      301 aggatgaata atttgtataa attagttcca acaagacgtt ttatcaagca attgaaaaaa
      361 ttggaccgtt atacgcagaa gctaattaca aactatttac aaaccaatgt tttggaagac
      421 ccaagacgac acggaaaggc tttggttggt aatcgcgttg gtcaatggcg ctatagaatt
      481 ggtaattatc gagttatcgt acaaattgta gatgatgaat tagtcgttgc tactctagaa
      541 gttggtcatc ggagagatat ttattgaatt aaagctgagt aataacagta tagaaagtaa
      601 ggagagtaaa aatttgaaga aaaaatggtt ttttgcagat tattatgaca caacaattat
      661 tttacttgct ttaatctctg ttattctggt attacttgga tttgctgaga tgactgattt
      721 ggacaatccg ccttatagta ttattgattt agtaatctgg ggtgtttttg taattgatta
      781 tagttggcgc ttttttatta ctaaaagaaa atggcgcttt attcttgaaa atatttttga
      841 tttattgacc attctccctt taaatgctat ttttacagtg tttcgattag gacgtatctt
      901 ccgcttagca aggctgacaa aattactgaa actgactcgt ttacttagaa taattggact
      961 tacaggtaaa ctagaaagaa aaattagtag attcttacga acaaatggat tgatttatat
     1021 cttgtatgtt aatatcttta ttgttctagt agggagttcg attttatccg ttgttgaaga
     1081 aaaatccttc tcagatagtc tttggtgggc tcttgtgaca gtaactactg ttggttatgg
     1141 tgatattgtt ccagtttccc tttttgggaa atggctagca gttttactga tgcttgtcgg
     1201 tattggaaca atagggatgc taacaagtgc tttgacgaac ttttttgtaa aggataatcc
     1261 agatgaacag ataaaacttg ataaactcaa agacgaatta tcgagctaaa gaatattaat
     1321 agagaaacaa tctgaaaaaa tcgaagaact acattgaatg ataaaagact tagttgaaaa
     1381 aatatcataa aggtgagaca aaataaaact tgattcgagg agaaatcaag taagtcttga
     1441 cacaatagaa cgcatattat caggtataaa aacttgatac tatgcgtttt atagagaaat
     1501 aaaataaaat ctgaacaaat caattaggaa tttaaagcat tttataacaa cgttttagag
     1561 tgatggggtg ctatttcaac ttcaacctac tataatacag aaaaaaacaa ctccctgatg
     1621 attcaaggag ttgtctatag ttaaattagt ttttagaagc ttcttggaat tctggatttt
     1681 tccatgcttc gtcaataata gcttgcaatt ctttagcaga tgcttgcatt ttttgagttt
     1741 ctgcatcgtt caatggaatg tttactggac gaacgatacc atgtgcacca acaacagctg
     1801 gttgaccgat aaagacattc tcaactccgt attgaccttc ttggaatact gaaagtggaa
     1861 gtactgcgtt ttcatcgtca aggattgctt tagtgatacg agcaagggct actgcgatac
     1921 cgtagtatgt tgcacctttt ttgttgatga ttgtgtaggc tgcatcacga acaccttcga
     1981 acaattcaat caattcagct tcttgaacat tttgagtgtc tttaaggaat tcttcaaggt
     2041 ttacaccagc gatgttagcg tgtgaccaaa cagcgaactc agagtcaccg tgttcaccca
     2101 tgatgtaggc gtgcactgaa cgagcatcca catccaattt ttcagcaagt gcttgacgga
     2161 aacgagctga gtcaagtgaa gtacctgaac cgataacgcg ttctttaggg aaaccagaga
     2221 atttccaagt tgagtaagtc aaaacgtcaa ctgggttagc agcaacaagg aagatacctt
     2281 tgaaaccaga ttcaacaact tgagttacga ttgatttgtt gatagcaagg tttttaccta
     2341 caaggtcaag acgagtttca cctggttttt gaggtgcacc tgcagtgatc acaacaaggt
     2401 cagcgtctgc acagtcagag tattgagctg catagatttt tttaggtgaa gtgaaggcaa
     2461 gggcgtgact aaggtcaagc gcatcaccaa cagctttttc atgcaattgt ggaatttcga
     2521 taattccaag ctcttgtgca attccttggt taacaagtgc aaaagcgtaa gatgaaccta
     2581 cagcaccatc accgacaagg ataacttttt tgtgttgttt agttgaagtc attgttttaa
     2641 acatctcctt aattttattg ggggattttc cctagacaac ttcattctat cacttttaaa
     2701 aaactttgtc acgaatatgc cttatagttc tcgatgtaaa cgttttagtg gtttagaggc
     2761 tgaaatagat gggaatttat ggtataatgt tgttacttac taattgtgaa atgaggcatt
     2821 tattaatgca ggataaaaat ttagtgaatg tcaatctgac aaaggagatg aaggcaagtt
     2881 ttatcgacta cgccatgagt gttatcgtag cgcgagctct tcctgatgtt cgagatggct
     2941 taaaacctgt tcaccgtcgc attctctacg gaatgaatga attgggtgtg accccagaca
     3001 aaccccataa aaaatctgct cgtattacag gggatgtcat gggtaaatat cacccacacg
     3061 gggattcctc tatttatgaa gccatggtcc gtatggctca atggtggagc taccgttaca
     3121 tgcttgtaga tggtcatggg aattttggtt ccatggatgg agatagtgct gccgctcaac
     3181 gttataccga ggcacgtatg agcaagattg ctctggaaat gcttcgtgat atcaacaaaa
     3241 atacagttga tttcgttgat aactatgatg ccaatgaacg ggaacccttg gtcttgccag
     3301 cgcgttttcc aaaccttttg gttaatggag caactggtat cgcggttggg atggcaacca
     3361 atattccacc tcataatctg ggtgaaacca ttgatgcagt gaagttggtc atggataatc
     3421 ctgaagtgac taccaaggac ttgatggaag tcttgcctgg accagatttt ccaactggtg
     3481 ctcttgtcat ggggaaatca ggtatccata aggcttatga aacaggtaaa ggttcgattg
     3541 tcctacgttc tcgtacagag attgaaacga ctaagactgg tcgtgagcgc atcgttgtaa
     3601 cagaatttcc ttacatggtc aataaaacca aggtgcatga gcatattgtt cgcttggttc
     3661 aggaaaaacg cattgagggt atcacagcag tacgtgatga gtcaaaccgt gaaggtgttc
     3721 gatttgttat tgaagtcaag cgcgacgcct cagccaatgt tattctcaat aacctcttca
     3781 aaatgaccca aatgcaaacc aattttggtt tcaatatgct cgctatccaa aatggtatac
     3841 cgaaaatttt gtctcttcgt cagattttgg atgcttatat cgagcaccaa aaagaagtgg
     3901 ttgttcgtcg tacacgtttt gataaggaaa aagcggaagc gcgcgctcat atcttagaag
     3961 gtctcttgat tgcgctagac catatcgacg aagtgattcg tatcatccgt gctagtgaaa
     4021 cggatgcgga agctcaagct gagttgatga gcaagtttaa gctttctgaa cgtcaaagtc
     4081 aagctatcct tgatatgcgt cttcgtcgtt tgacaggttt ggaacgcgat aagattcaat
     4141 ctgagtatga tgacctcttg gctctgattg cggatttagc agatattctt gctaagcctg
     4201 aacgtgtttc tcaaattatc aaagacgaat tggatgaagt taaacgtaaa ttttctgata
     4261 aacgccgtac agagttgatg gttggacaga tcttgagtct cgaggatgag gacttgattg
     4321 aagaatcgga tgtcttgatt accctttcta acagaggcta cattaagcgt ttggatcagg
     4381 acgagttcac tgctcaaaaa cgtgggggtc gtggtgtcca aggaatggga gtgaaagatg
     4441 atgactttgt tcgtgagtta gtgtcaacta gcacacatga tcatctgctc ttcttcacaa
     4501 acaagggacg tgtctatcgt cttaaaggtt atgaaattcc tgagtatggt cggactgcca
     4561 aagggctacc agtagtcaat ctcttgaaat tggatgaaga cgaaagtatt cagacggtta
     4621 tcaatgttga gtctgatcgc agtgatgatg cttatctctt ctttacaacc cgtcacggta
     4681 ttgtgaagag aactagtgtt aaggagtttg ccaatattcg tcaaaatggt ctcaaagcgc
     4741 tgaatttaaa ggatgaagat gagttaatca atgtcttgtt ggcagaagga gatatggata
     4801 ttatcattgg taccaagttt ggttatgcag ttcgctttaa tcaatcagcc gttcgtggta
     4861 tgagccgtat cgccactggt gtgaaaggtg ttaaccttcg tgaaggagac acagttgttg
     4921 gtgccagctt gattactgat caagatgagg ttcttattat cacagaaaaa ggatatggta
     4981 agcgtacagt cgctactgaa tacccaacaa aaggtcgtgg tggtaaggga atgcagacag
     5041 ctaaaattac cgaaaaaaat ggcttgctgg ccggtcttat gactgttcaa ggggatgagg
     5101 atttgatgat tatcactgat acaggtgtca tgattcgaac caatcttgcc aatatttcac
     5161 aaacaggacg tgcaactatg ggagttaaag taatgcgcct ggatcaagat gctcagatag
     5221 tgactttcac aacggttgcg gtggcagaaa aagaagaagt tgggacagaa aacgaaacag
     5281 aaggtgaagc ataatgtctc aaaaaaataa taaaaagaaa aacaagcgaa aaaatctgct
     5341 gacaaatatc ctagcaggat ttctgatatt actgtcactg gctttgattt ttaatactca
     5401 aattcgaaat attttcatag tctggaatac caataagtat caagttagcc aggtatcaaa
     5461 agaaaaatta gaagaaaatc aggatacaga aggcaatttt gactttgatt ctgtcaaagc
     5521 tatctcttcg gaagctgttc taacttctca atggaatgct caaaaattac cagttattgg
     5581 gggaattgca attcctgaat tggaaatgaa tttgccgatt tttaaaggac ttgataatgt
     5641 taatctcttc tacggagctg gtacaatgaa acgcgagcaa gtaatgggag aaggaaatta
     5701 tagtctagct agtcaccata tctttggtgt tgataatgct aataaaatgt tattttctcc
     5761 tttagataat gctaaaaatg gcatgaagat ttatctaacc gataaaaata aagtttatac
     5821 ttatgaaata cgtgaagtca aacgtgtgac accggatcgt gttgatgaag ttgatgatag
     5881 agatggggtc aatgaaatca cattagtaac ctgtgaagac cttgctgcta cagaacgtat
     5941 tattgtcaaa ggtgatttga aagaaacaaa agattattca caaacatctg atgaaatcct
     6001 aacagctttc aatcaaccat ataaacaatt ttattaatac aaatcagtga aatcatggat
     6061 ttcactgatt ttttaagatt ttcat
//
LOCUS       DAVLHC010000081         6015 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.082, whole genome shotgun sequence.
ACCESSION   DAVLHC010000081 DAVLHC010000000
VERSION     DAVLHC010000081.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 6015)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6015)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6015
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.082"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..571
                     /locus_tag="VXE25_002009"
     CDS             <1..571
                     /locus_tag="VXE25_002009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000417187.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772408.1"
                     /translation="NGYYTIDLFSPIYSALSGEKGTPGDLMGRRIAFELLAAKGYKEG
                     MVPYISNQYEKDAKAAGSKIKSYGKEVGLVTDKLVLEKVFNNRYSSWVEFKKAMYNER
                     IAKFNNLISVSFNNPNVSWGRTNRITITSIANLQNMINTAVNEDAEDFRAQLYPDTNS
                     RVLKLKKAIYKAYLDQTNDFRRSIFENKK"
     gene            615..>6015
                     /locus_tag="VXE25_002010"
     CDS             615..>6015
                     /locus_tag="VXE25_002010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000054780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="G5 domain-containing protein"
                     /protein_id="HEV0772409.1"
                     /translation="MSLLKKDKFSIRKIKGIVGSIFLGSFLFALSVVGVSTYHYLDYS
                     TLTQTERDQLKQGRPDESKESYALVYEKDALPNTGSSQSIMTVLGLLAIGSLIVIITK
                     DKKRKKIATFLIVGATGLVTLSTASALNLNANIHESGRDGVLQISGYRYVGYLELDDR
                     TVSSVSPASTVSPVEQPKVVTDKGEPEVQPALPEAVVTGKGKTEVQPTLPEAVVTEKG
                     EPEVQPVLPEAVVAEKGEPEVQPVLPEAVVTEKGEPEVQPALPEAVVTEKGEPEVHEK
                     PDYTQPIGANLVESEVHEKLAYTEPVGTTGVDENGNLIEPPVNDIPEYTEPISTVSEV
                     ASEREELPSLHTDIRTETIPKTTIEESDPSKFIGDNSVKQVGEDGERQIVTSYEELHG
                     KKISESVETVTILKEMKPEIIVKGTKERPKEKTAPVLTLTKVTEDAMNRSANLNYELD
                     NKDNAEISSIVAEIKDGDTVVKRVDLSKEKLTDAVQNLDLFKDYKIATTMIYDRGQGS
                     ETSKLDERPLRLELKKVEIKNIASTNLVKVNDDGTETPSDFMNEKPSEEDVKKMYLKI
                     TSRDNKVTRLTVDSIEEVTEEGQKLYKITAEAQDLIQHTDPTKVRNKYVYYIEKPHPK
                     EDNVYYNFKDLVDAMNTDKNGTFKLGADLNATGVPTPKKWYVDGDFRGTLKSVEGKHY
                     TIHNTERPLFQNIIGGTVTKVNLGNVNINMPWADRIAPIADTIKGGAKIEDVKVTGNV
                     LGRNWVSGFIDKIDNQGTLRNVAFIGNVTSVGDGGQFLTGIVGENWKGLVERAYVDAN
                     LIGKKAKAAGIAYWTQNSGDNHKVGVEGAVKKGIVKGTIQVESPVEVGGAVGRLSHHG
                     YIGEVVSMMKVKKGEIFYGSSDMNDDPYWVANNVRGNYVVNGVSEGTISYARAKEHHR
                     IKPISQSEADTKIMMLGITAQDFAVNEPVVNRLNRLTRKEDEYKSTQDYKVDRDLAYR
                     NIEKLQPFYNKEWIVNQGNKLAEDSNLAKKEVLSVTGMKDGQFVTDLSDIDKIMVHYA
                     DGTKEEMDVTKNADSKVKQVREYTIAGQNVVYTPNMVEKDRNQLIQDIKDKLASVQLI
                     SPEVRALMDARKKPEENTDERKNGYIKDLYLEESFAETKANLDKLVKSLVENADHQLN
                     SDEAAMKALVKKVDENKAKIMMALTYLNRYYDIKYGDMTIKNLMMFKPDFYGKSVDLL
                     DFLIRIGSSERNIKGDRTLDAYRDMIGGTIGKSELHGFLDYNMRLFTNDTDLNDWFIH
                     AAKNVYVSEPQTTNPDFVNKRHRAFDGLNNGVHNRMILPLLTLKNAHMFLISTYNTMA
                     YSSFEKYGKYTEEARNEFKKEIDKVAHAQQTYLDFWSRLALPSVRDQLLKSENRVPTP
                     VWDNQNYSGIKGINRMGYDEKKVPIAPIRELYGPTWKFHNTNWNMGAMASIFPNPNNN
                     DQVYFMGTNMISPFGISAFTHETTHVNDRMLYFGGHRHRQGTDVEAYAQGMLQTPSSI
                     GHQGEYGALGLNMAYHRENDGDQWYNYDPDKLQTREDIDRYMKNYNEALMMLDHVEAD
                     AVLPQLNGDNSKWFKKIDREMRRNLGDGLNNLVAPHQWDNVRDLNQEESSKKLSSIND
                     LIDNNFMTKHGNPGNGRYRPEDFRPNSAYVNVNMMAGIYGGNTSQGAPGSLSFKHNAF
                     RMWGYYGYDKGFTSYVSSKYQGEADKQNQGRLGDDFIIKKVSNNQFSNLEDWKKYWYH
                     DVKSRAEKGFTEITIDGQTIHNYNELKDLFDKAVTEDLKKAGNYSNTENLKSKVFKAL
                     LKNTDGFFNPLFKKDI"
BASE COUNT         2150 a          915 c         1257 g         1693 t
ORIGIN      
        1 aaatggttat tatacaattg atttattttc accgatttat tcagctctta gtggagagaa
       61 agggactcct ggtgatttaa tgggacgtcg tatagcattc gaattattag ctgcaaaagg
      121 atataaagag ggcatggtac cttatatctc aaatcaatat gaaaaagatg caaaagctgc
      181 gggaagtaag attaaatctt atggtaaaga agtaggttta gttacagata aattagtact
      241 tgaaaaggta tttaataatc gttactcatc ttgggtagaa tttaaaaaag caatgtataa
      301 tgagcgaata gctaaattta ataatctaat aagtgttagc tttaataatc caaatgtaag
      361 ttggggaaga actaatagaa taacaataac tagcatagcc aaccttcaaa atatgataaa
      421 tacggctgtc aatgaagatg ctgaagattt tagagcacaa ttataccctg atacaaatag
      481 tagagttctt aaactgaaaa aagcaatata taaagcctat cttgaccaaa caaatgattt
      541 tagaagatca atttttgaga ataaaaaata gtgtttacta ttaggaaata aaaagtgaat
      601 gtggaggatt agaattgtca ttattaaaaa aagataaatt ttccattagg aaaataaagg
      661 gtattgttgg ttcgatattc ttggggagtt ttttatttgc actgtcagtt gttggtgtat
      721 cgacttatca ttacttagat tatagtactt tgacacaaac tgaacgtgat caactcaaac
      781 aaggtagacc tgatgaatca aaagagtcat atgctttggt ttatgaaaaa gacgcattac
      841 caaacacagg aagttctcaa tctattatga ctgtattggg tttgttagct atcgggagtc
      901 ttattgtgat tatcacaaaa gataaaaaga ggaaaaaaat agctacattt ttgattgtag
      961 gggcgacagg tttagttaca ctatcaactg cttcagcact taatttgaat gctaacatcc
     1021 atgagtctgg acgtgatggt gtgttgcaaa tttctggtta cagatatgtt ggttacttgg
     1081 agcttgatga tagaactgtt tcgtcggttt ctccagcatc aactgtttct ccagttgagc
     1141 aacccaaagt tgtgactgac aaaggcgaac cagaagttca gccagcgtta ccagaagcag
     1201 ttgtaactgg aaaagggaaa actgaagtac aaccgacatt accagaagct gttgtgactg
     1261 aaaaagggga accggaagta caaccagtgt taccagaagc tgttgtggct gaaaaagggg
     1321 aaccggaagt acaaccagtg ttaccagaag ctgttgtgac tgaaaaaggg gaaccagaag
     1381 tacaaccagc cttacccgaa gcagttgtaa ctgaaaaagg cgaaccagaa gttcatgaga
     1441 agcctgacta tacgcaacca ataggtgcaa accttgttga gtctgaagtt catgagaaac
     1501 tagcatacac tgaacctgta ggtacaacag gagtagatga aaatggaaac ttgattgagc
     1561 cacctgttaa cgatattcca gagtatactg aaccaatatc tacagtttca gaagttgcat
     1621 cagaaagaga agagttgcct tctttacata ccgatattcg tacagagact attcctaaaa
     1681 ccactataga agaatctgat cctagcaaat ttataggcga taattctgtt aaacaagttg
     1741 gtgaggatgg cgaacgtcaa attgttacta gctatgaaga gttacatggc aaaaaaatca
     1801 gcgagtcagt tgaaacagta acaattttga aagaaatgaa gcctgaaatt attgtaaaag
     1861 gtacaaaaga aagaccaaaa gaaaaaacgg ctcctgtttt aaccttgacc aaagtaacag
     1921 aagatgctat gaatcgttct gccaacttaa attatgagct tgataataaa gataatgctg
     1981 aaatatcaag tattgtagct gaaattaaag atggtgatac agtagttaaa agggttgatt
     2041 tatctaaaga aaaattaact gacgctgtac aaaatttgga tttgtttaaa gattataaga
     2101 ttgcaacaac aatgatttat gatcgtggtc aaggttctga aacgtctaaa ctggatgaaa
     2161 gacctctgcg tttggagttg aaaaaggtcg aaattaaaaa tatcgcatct actaatttag
     2221 tgaaggtaaa tgatgatggt actgaaacac ctagtgattt tatgaatgaa aaaccttcag
     2281 aagaagatgt taaaaaaatg tacttaaaaa tcactagtcg cgataataag gtaactcgtt
     2341 taactgtaga ctctattgaa gaagtgactg aagaaggtca aaaactttac aaaataactg
     2401 ctgaagcaca agatttgatt caacacacag acccaacgaa ggttcgtaat aagtatgttt
     2461 attatataga aaaaccccat cctaaagaag ataatgtcta ctataacttt aaagatttag
     2521 tagatgctat gaatactgat aaaaatggta catttaaact tggtgcagat ttgaatgcca
     2581 ctggtgttcc aacacctaag aaatggtatg ttgacggcga ctttagaggt acattgaaga
     2641 gtgtagaggg gaaacattat actatccaca acacggagcg tccgttattc cagaatatta
     2701 ttggtggtac agtaaccaaa gtaaatctgg gaaatgtaaa tatcaatatg ccatgggcag
     2761 accgcatcgc accgattgct gacactatta aaggtggcgc taaaattgaa gatgtcaaag
     2821 tgactggtaa cgtattaggt agaaactggg tatctggatt tattgataag attgacaacc
     2881 aaggtacact cagaaatgta gcctttatcg gaaatgtgac atctgtaggt gatggtggtc
     2941 aattcttgac cggtatcgtt ggtgagaact ggaaaggact agtcgaacgt gcgtatgttg
     3001 acgcaaatct tattggcaag aaagccaagg ctgctggtat tgcttattgg acacaaaaca
     3061 gtggtgacaa tcataaagtt ggtgtcgaag gtgcagtcaa gaaaggaatt gtgaagggta
     3121 ccattcaggt agaaagtcct gttgaagtcg gcggtgctgt tggacgtttg agtcatcatg
     3181 gttatatcgg ggaagtcgta tctatgatga aagttaagaa gggtgaaatt ttttatggtt
     3241 ctagtgatat gaatgatgac ccatattggg tggcgaataa tgtacgagga aattatgtag
     3301 ttaatggtgt gagtgaaggt acgatatctt atgctcgtgc taaagaacac catcgtatca
     3361 aaccaatttc acagtcagaa gcagatacta aaattatgat gttaggtatt acagcacaag
     3421 attttgctgt caacgaacct gtggtcaatc gcttaaaccg tttaaccaga aaagaagatg
     3481 aatataagtc aacccaagac tataaagtag atcgagatct ggcttatcgt aatattgaga
     3541 aacttcaacc attttataac aaagaatgga ttgtcaacca aggtaacaaa cttgcagaag
     3601 attcaaactt agctaagaaa gaagtccttt ctgttacggg tatgaaggat ggacagtttg
     3661 taactgactt atcagatatt gataagatta tggttcacta tgctgatggt actaaagaag
     3721 aaatggacgt cactaagaat gctgattcta aagtgaaaca agttcgtgaa tataccatcg
     3781 ctggacaaaa cgttgtttat acaccaaata tggttgagaa agaccgtaac caattgattc
     3841 aagatatcaa agataagttg gcgtcagttc aattgatttc tcctgaagta cgtgctttga
     3901 tggatgcacg taagaaacca gaagaaaata ctgatgaacg taagaatggt tatattaaag
     3961 acctttactt agaagaaagc tttgctgaaa cgaaagctaa tcttgataaa ttggttaaat
     4021 ccttagttga aaatgcagat catcaattaa atagtgacga agcggctatg aaagcacttg
     4081 ttaagaaggt ggatgaaaat aaagctaaaa tcatgatggc tctgacttat ctcaatcgtt
     4141 actatgatat caagtatggg gatatgacta tcaagaactt gatgatgttt aaacctgatt
     4201 tctatggtaa atcagttgac cttcttgatt tcttgattcg aattggatca agtgagagaa
     4261 atatcaaagg tgacagaact ttggatgctt atcgtgatat gattggtgga actattggta
     4321 agtctgaatt acatggattc ttagattaca atatgcgtct cttcactaac gatactgatt
     4381 taaatgattg gttcatccat gcagctaaga atgtatatgt atcagaacct caaacaacga
     4441 acccagattt tgttaataaa cgacatcgtg catttgatgg tttgaacaac ggtgttcata
     4501 atcgtatgat tctacctcta ttaactctta agaatgcaca tatgttcttg atttcaactt
     4561 acaatacaat ggcttatagt tcttttgaga aatatggtaa gtatacagaa gaagctagaa
     4621 atgaattcaa aaaagaaatt gataaggttg cacatgctca acaaacatac ttagacttct
     4681 ggtcacgttt agcattgcca agcgtacgtg accaattact caagagtgag aatagggtac
     4741 caactcctgt gtgggataac caaaactata gtggtattaa aggaataaac cgtatgggtt
     4801 atgatgagaa gaaagtacca attgcgccaa ttcgtgagtt atatggtcca acttggaaat
     4861 tccataatac caactggaat atgggagcta tggcatctat tttcccaaat cctaataaca
     4921 atgaccaagt ttatttcatg ggaacaaata tgattagtcc gtttggtatt tcagccttta
     4981 ctcatgaaac tacacacgtt aatgatagaa tgctttactt cggtggtcat agacaccgtc
     5041 aaggtacaga cgtcgaagcc tatgctcaag gtatgctaca aactccgtca agtattggtc
     5101 accaaggtga atatggtgct ttaggtttga acatggctta tcatcgtgaa aatgatggtg
     5161 accaatggta taactatgac cctgataagc ttcaaactcg tgaagatatc gatcgatata
     5221 tgaaaaacta taatgaagca ctgatgatgc tagatcatgt agaagcagac gccgtacttc
     5281 cacaattgaa tggtgataat agcaagtggt tcaagaaaat tgatagagaa atgcgcagaa
     5341 atcttgggga tggtttgaat aacttagtag caccgcacca atgggacaac gttcgtgact
     5401 taaatcaaga agagagttct aagaaattat caagtattaa cgatttgatt gataataatt
     5461 tcatgaccaa acacggaaat ccaggtaacg gacgttatag accagaggat tttagaccaa
     5521 actcagctta cgtaaatgtc aatatgatgg caggaattta cggtgggaat acgagtcaag
     5581 gtgctcctgg ttcattatcg ttcaaacata atgccttccg tatgtggggt tattatggat
     5641 atgacaaagg tttcactagt tatgtatcta gcaaatatca aggtgaagct gataaacaaa
     5701 accagggtag attaggtgat gatttcatta tcaaaaaagt ttcaaacaac caattctcaa
     5761 atcttgaaga ttggaagaaa tattggtatc atgatgtgaa atccagagct gaaaaaggat
     5821 tcacagagat tacaattgat ggacaaacca ttcacaacta taatgaactg aaagacttat
     5881 tcgacaaagc tgtcacagaa gacctcaaga aagctggaaa ctactcaaat actgagaatt
     5941 tgaaatccaa agtcttcaaa gctcttctta aaaacacaga cggtttcttt aatccattgt
     6001 tcaaaaaaga cattt
//
LOCUS       DAVLHC010000082         5655 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.083, whole genome shotgun sequence.
ACCESSION   DAVLHC010000082 DAVLHC010000000
VERSION     DAVLHC010000082.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 5655)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5655)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5655
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.083"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(<1..210)
                     /locus_tag="VXE25_002011"
     CDS             complement(<1..210)
                     /locus_tag="VXE25_002011"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772410.1"
                     /translation="MNTIERTRRLIKGCATHCFEVVDRTDEVSSKHCFEVADRTDEVS
                     SKHVFEVVDETNEVSSKHVFEVVDET"
     gene            complement(274..1284)
                     /gene="ccpA"
                     /locus_tag="VXE25_002012"
     CDS             complement(274..1284)
                     /gene="ccpA"
                     /locus_tag="VXE25_002012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000990602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="catabolite control protein A"
                     /protein_id="HEV0772411.1"
                     /translation="MNADDTVTIYDVAREAGVSMATVSRVVNGNKNVKENTRKKVLEV
                     IDRLDYRPNAVARGLASKKTTTVGVVIPNITNGYFSSLAKGIDDIAEMYKYNIVLANS
                     DEDNEKEVSVVNTLFSKQVDGIIYMGYHLTDKIRSEFSRSRTPIVLAGTVDVEHQLPS
                     VNIDYKQATIDAVSYLAKENERIAFVSGPLVDDINGKVRLVGYKETLKKAGITYSEGL
                     VFESKYSYDDGYALAERLISSNATAAVVTGDELAAGVLNGLADKGVSVPEDFEIITSD
                     DSQISRFTRPNLTTIAQPLYDLGAISMRMLTKIMHKEELEEREVLLPHGLTERSSTRK
                     RK"
     gene            complement(1709..2308)
                     /locus_tag="VXE25_002013"
     CDS             complement(1709..2308)
                     /locus_tag="VXE25_002013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEV0772412.1"
                     /translation="MKVLVAEDQSMLRDAMCQLLMLQPDVESVFQAKNGQEAIQLLEK
                     ESVDIAILDVEMPVKTGLEVLEWIRAEKLETKVVVVTTFKRPGYFERAVKAGVDAYVL
                     KERNIADLMQTLHTVLEGRKEYSPELMEVVMMHPNPLTEQEIAVLKGIAQGFSNQEIA
                     DKLYLSNGTVRNYVTNILSKLDAGNRTEAANIAKESGWL"
     gene            complement(2309..3406)
                     /locus_tag="VXE25_002014"
     CDS             complement(2309..3406)
                     /locus_tag="VXE25_002014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001848091.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEV0772413.1"
                     /translation="MLERLKRIHYMFWISLIFMIFPILSVVTGWLSAWHLLIDILFVV
                     AYLGVLTTKSQRLSWLYWGLMLTYVVGNTAFVAVNYIWFFFFLSNLLSYHFSVRSLKS
                     LHVWTFLLAQVLVVGQLLIFQRIEVEFLFYLLVILTFVDLMTFGLVRIRIVEDLKEAQ
                     VKQNAQINLLLAENERSRIGQDLHDSLGHTFAMLSVKTDLALQLFQMEAYPQVEKELK
                     EIHQISKDSMNEVRTIVENLKSRTLTSELETVKKMLEIAGIEVQVENHLDKSSLTQEL
                     ESTASMILLELVTNIIKHAKASKVYLKLERTEKELILTVRDDGCGFASISGDELHTVR
                     NRVFPFSGEVSVISQKHPTEVQVRLLYKERK"
     gene            complement(3406..4143)
                     /locus_tag="VXE25_002015"
     CDS             complement(3406..4143)
                     /locus_tag="VXE25_002015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004249339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEV0772414.1"
                     /translation="MKRWLALSKIEFLLTKRQLIYYLLSVGMPTAFYLFFSGMYQDTP
                     GGPANFMRDYLISMTGFSMMSTAIFSFPAVLHTDKMNNWQKILRHSPVNMVEYYLSKI
                     TSMLVDYLVSILVVFTVGHFVRGVDMPLVKWVGAAILLILGSIAFVALGLTLTLLPTS
                     QLMSVVGNLLYLGLAVLGGLWMPVSLFPDWMQAIGKRLPSYQLMELIKTFLNEGGINL
                     SATVYLLVFSAVLFGLTIYLQGHKENA"
     gene            complement(4145..5029)
                     /locus_tag="VXE25_002016"
     CDS             complement(4145..5029)
                     /locus_tag="VXE25_002016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000219360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0772415.1"
                     /translation="MTVVKVEKLSKKIKDKEILRNISFEINDGECVALIGPNGAGKTT
                     LLDCLLGDKLVTSGQVSIQGLPVTSSKLDYTRAYLPQENVIVQKLKVKELIAFFQRIY
                     PNPLSNQEVDQLLQFVKQQKEQLAEKLSGGQKRLFSFVLTLIGRPKIVFLDEPTASMD
                     TSTRQRFWEIVQELKAQGVTILYSSHYIEEVEHTADRILLLNKGELIRDTTPLAMRSE
                     GIEKHFILPLAYKEVIEQSNLVENWSQKQDALQVVTREADAFWELLVQAGCGIQEIEV
                     NNRSLLDTIFEETQKGDN"
     gene            complement(5016..5210)
                     /locus_tag="VXE25_002017"
     CDS             complement(5016..5210)
                     /locus_tag="VXE25_002017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000820182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772416.1"
                     /translation="MKKGIIYFFIGLSLLVWLVEMFTDWFDQALLRQFIRGALGFGFM
                     IFVVFPMGMEWLKGESHDCG"
     gene            complement(5207..5413)
                     /locus_tag="VXE25_002018"
                     /pseudo
     CDS             complement(5207..5413)
                     /locus_tag="VXE25_002018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000503440.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
BASE COUNT         1776 a         1276 c          931 g         1672 t
ORIGIN      
        1 agtttcatct acaacctcaa aaacatgttt tgagctgact tcgttagttt catctacaac
       61 ctcaaaaaca tgttttgagc tgacttcgtc agttctatct gcaacctcaa agcagtgctt
      121 tgagctgact tcgtcagttc tatctacaac ctcaaaacag tgtgttgcgc agcctttaat
      181 cagccgccta gtccgctcta tggtattcat taagtcaaca tctcttgttt aagagcacca
      241 aatcaggaaa tcttctcgat tccctgattt tttctattta cgttttcgtg ttgagctacg
      301 ttctgtcaaa ccatgaggta agagaacttc acgttcttcc aactcttcct tatgcataat
      361 cttggtcaac atacgcatac taatggcacc aaggtcataa agaggttggg caatcgttgt
      421 caagtttgga cgggtaaagc gtgagatttg tgaatcatca ctagtaataa tttcaaaatc
      481 ttctggcaca gaaacaccct tatcagccaa accgttcaag actcctgctg ccaactcatc
      541 acctgtcaca actgctgcag ttgcatttga tgaaatcaaa cgctctgcta aggcgtaacc
      601 atcatcatag ctatatttag attcaaatac caaaccctca ctataagtga ttcctgcttt
      661 tttcaaggtt tccttgtagc caactaaacg aaccttacca ttgatgtcat ccactagcgg
      721 accgctaacg aaagcaatac gctcattttc tttagcaagg taactcactg catcaattgt
      781 tgcttgctta tagtcaatat tgacacttgg caactggtgc tcaacatcga cagttcctgc
      841 gagaacaatc ggagtacgtg aacgcgaaaa ttctgagcga attttatctg tcaagtgata
      901 ccccatatag ataatgccat ctacctgctt tgaaaagagg gtattgacaa cagaaacttc
      961 tttctcgtta tcttcatcgc tattagctag gacaatattg tacttgtaca tttctgcaat
     1021 atcatcaatc cccttagcca aactcgaaaa ataaccattg gtaatatttg gaatcacgac
     1081 accgacagtg gttgtctttt tacttgcaag accacgcgca actgcatttg gacgataatc
     1141 caaacgatca attacctcta gcactttttt acgggtattc tcttttacat ttttattgcc
     1201 attgaccaca cggctgaccg tcgccatgga aacacctgct tcacgagcga catcataaat
     1261 ggttactgta tcatctgcat tcattccttt tcctgtcctt tctatctcac acattctttt
     1321 acaagtagag gtactgattg aagctctata tctacttaca aaagtgaaga tgtgaaaatt
     1381 tcgttttcat atttctactt attccattct atcactaatt gtaaacactt tcaagtgttt
     1441 tttgaagatt gattgaaaaa atttcataga aaacctaggt ttagctcctt gctaccacct
     1501 tagactaaac aaaaaggagg aaactaagcc ctcctaaagt tatagtaaaa tgaaataaga
     1561 acaggataaa tcgatcagga cagtcaaatc gatttctaac aatgttttag aagtagaggt
     1621 gtactattct agtttcaatc tactataggt attgttccat tcactaccgt caattttagc
     1681 acatagtctt catgaaaata ttatatcatc ataaccaacc agattctttc gcgatattag
     1741 ctgcctctgt tcgattacct gcatctagtt tcgaaagaat attggtgaca tagtttcgga
     1801 ctgttccgtt ggatagataa agtttgtctg caatttcttg gttagagaag ccctgagcaa
     1861 ttccctttaa aactgcgatt tcttgctccg ttaatggatt gggatgcatc atcaccactt
     1921 ccatcaattc aggcgaatac tccttgcgtc cttcgaggac ggtgtgcaag gtttgcatga
     1981 ggtctgcaat gtttctttct tttaatacat aagcatctac tccagccttg accgcacgtt
     2041 caaaataccc aggacgcttg aaggtcgtca ccacaaccac ctttgtttca agcttttctg
     2101 ctcgtatcca ctccaagact tcaagacctg tcttaacagg catttctacg tcaaggatgg
     2161 cgatatctac agactccttt tctaatagtt ggattgcttc ttgcccattc ttggcttgaa
     2221 agacagactc tacatccggt tgaagcatga gcaactggca catggcatct cgcaacatac
     2281 tttgatcttc tgcgactaat actttcatct actttctctc cttataaagt agtcgaacct
     2341 gcacttcagt tggatgtttc tgactgatta cacttacttc tcctgaaaat ggaaaaacac
     2401 gatttcggac tgtatggagc tcatccccgc ttatagaggc aaagccacag ccatcatctc
     2461 tcactgttag aatgagttct ttctctgtcc gttctaattt caagtagact ttagacgctt
     2521 tagcatgttt gatgatattg gtcactaatt caagcaaaat catggaagcc gttgactcca
     2581 attcctgagt taagctagac ttgtccaagt gattctcaac ttgaacctca attccagcaa
     2641 tttctaacat ctttttcaca gtctctagtt cggatgtcaa agttctagac ttaagatttt
     2701 ccacaatggt tcgcacttca ttcatggaat ccttgctgat ctggtgaatt tcttttaatt
     2761 ccttttccac ctgtggataa gcctccatct gaaataactg caaggctaaa tctgtcttga
     2821 cactcagcat agcaaaggta tgtcccagac tatcatgcaa atcctgaccg atacgactac
     2881 gttcattttc agcaagcaat agatttatct gagcattttg cttgacctga gcttctttca
     2941 aatcctcgac aatacgaatc cgaaccaatc caaaagtcat taaatcgaca aaagtaagaa
     3001 ttacaagtag atagaataga aactcaactt cgattctctg aaaaatcaac agttgcccca
     3061 caacaaggac ttgagcaaga agaaaagtcc agacatgtaa agactttaaa ctacgtacgc
     3121 tgaaatgata acttaagaga ttggatagga aaaagaaaaa ccagatataa ttaacagcaa
     3181 caaaggcagt attcccaact acataagtca gcatgaggcc ccaatatagc caagataggc
     3241 gctggctctt agttgttaaa acacccaaat atgccactac aaatagaata tcaatcaata
     3301 aatgccaggc agaaagccac ccagtcacta cagacaggat ggggaaaatc ataaaaatta
     3361 aactgatcca aaacatataa tgtattcttt tcagtctttc aagcattaag cattctcctt
     3421 atgaccttga aggtaaatag tcaaaccaaa taaaactgct gaaaaaacaa gtagataaac
     3481 tgtggctgat agattgattc caccctcatt taagaaggtc ttgattaatt ccatcaactg
     3541 ataacttggt aaacgcttcc cgattgcttg catccagtct ggaaataaag agacgggcat
     3601 ccagagtccg cctaaaacag ccaatcctag ataaagaaga ttgcccacga cagacatcag
     3661 ctgactagtt ggtaacagcg tcaaggttaa gccaagtgct acaaaagcaa tacttcccaa
     3721 aatcagcaaa atcgcagctc caacccattt tactagaggc atgtctacac ctcttacaaa
     3781 atgtccaact gtaaaaacaa ccagaattga gaccaaataa tcaaccagca tacttgttat
     3841 ctttgataga taatattcta ccatatttac tgggctatga cgtaatattt tctgccagtt
     3901 gttcatcttg tcggtatgta agacagctgg gaatgaaaag atagcggtcg acatcatgga
     3961 aaagccagtc atggagatga ggtaatcacg cataaaattc gcgggtccac ctggtgtgtc
     4021 ctggtacatg ccagaaaaga atagatagaa ggctgtcggc atccctactg acaatagata
     4081 atagatcaat tgtcgtttgg tcaataaaaa ttctatctta ctaagtgcta gccatcgttt
     4141 catcttagtt atctcccttc tgcgtttctt caaagattgt atccaacaaa ctacgattat
     4201 taacttcaat ttcttgtatg ccacatcctg cttgaactaa cagttcccaa aaagcatctg
     4261 cttcgcgtgt gactacttgt agagcatcct gtttttgtga ccagttttca accaagttag
     4321 actgctcaat gacttccttg tatgccagag gaaggataaa atgcttttca attccctcac
     4381 tacgcatagc tagaggcgtc gtatcacgaa tcaactctcc cttatttaag agcaaaatgc
     4441 ggtctgcagt gtgttccact tcctcaatat aatgggacga atagagaatg gtgactcctt
     4501 gcgcttttaa ctcctggaca atttcccaaa aacgttgacg agttgaggta tccatggacg
     4561 cagtaggctc atctaaaaaa acaatctttg gtcgcccaat taaggtcaag acgaaagaaa
     4621 agagacgctt ttgaccgcct gataattttt ctgccaactg ttctttttgt tgcttgacaa
     4681 actgcaatag ttgatcaact tcctgattgc tcaaaggatt tggatagata cgttgaaaga
     4741 aagcaatcaa ctctttaact tttaatttct gaacgattac attttcttga gggaggtaag
     4801 ccctagtata gtctaactta gaactcgtca ctggtaaacc ttgaatagat acttgaccgc
     4861 ttgtgaccag tttatctcca agcaaacaat ctaagagtgt tgtctttccg gcaccatttg
     4921 gaccaattaa ggcaacacat tcaccatcgt tgatttcaaa ggagatgttc cgcaaaattt
     4981 ccttgtcttt tattttctta ctcaattttt caactttaac cacagtcatg agactctcct
     5041 ttcaaccact ccattcccat agggaaaacg acgaaaatca taaatccaaa ccccaaagca
     5101 ccacgaatga attggcgaag caaggcttga tcaaaccaat cagtaaacat ttccactaac
     5161 cataccaaga gtgacaggcc gataaagaaa tagatgatcc ctttcttcat tcctcaaact
     5221 cctttttcac atctctgact aatttcaaac cttctctaac aagccaagac atgattccaa
     5281 agccagcaaa gatctttcaa ggaaaatggt agaaatcctc atccaatccc gaaaacatga
     5341 gataggtcat aactcctgct actactaaac ttactgcgat aatcatttta tttctcatct
     5401 cttcttcccc catttcatac tacaattata gtcttttaaa atcagaggag gcagaagctt
     5461 ctgtcactag aaaatatgac aaatgtcata aaaaattctg ttcaaaacaa gcaagataca
     5521 ctatacaata aaacacaatc agaaaaatct aaggcaactt cctcaaaaga gatatcaaac
     5581 ccaattcaca ccataatgta aactaatact tatttaaaat caaaaagagt agaaattttt
     5641 atcagacaaa cacat
//
LOCUS       DAVLHC010000083         5585 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.084, whole genome shotgun sequence.
ACCESSION   DAVLHC010000083 DAVLHC010000000
VERSION     DAVLHC010000083.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 5585)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5585)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5585
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.084"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            128..1882
                     /locus_tag="VXE25_002019"
     CDS             128..1882
                     /locus_tag="VXE25_002019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398247.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0772417.1"
                     /translation="MKIYKKLFAYVQDKKYLGVLAIIFSAISAALTVYGYYLIYKFLD
                     KLIINSNLSGAESIALKSVITLTSGAIFYFVSGMFSHILGFRLETNLRKRGIDGLEKA
                     SFRFFDLNPSGQIRKIIDDNAAQTHQVVAHMIPDSSQAIVTPILVLVLGFIVSIRVGI
                     TLLALTIIGGLILGAMMGEQEFMKIYQEALSKLSAETVEYVRGMQVVKIFKANVESFK
                     SFYKAIKDYSKYAYDYSLSCKRPYVLYQWLFFGLIAILIIPIVYFMTSLASAKVILLE
                     LIMILFLSGVLFVSFMRMMWYSMYISQGNYAVDTLEALYEDMQKDKLVHGNVNNFKNY
                     NIEFENVSFAYNDKAVIENLSFNLEEGKSYALVGSSGSGKSTVAKLISGFYNVNKGSI
                     KIGGIAISEYSDEALIKAISFVFQDSKLFKKSIYDNVALANKDATKDDVMRALKLAGC
                     DLILDKFPERENTIIGSKGVYLSGGEKQRIAIARAILKDSKIIIMDEASASIDPDNEF
                     ELQKAFKNLMKDKTVIMIAHRLSTIKDLDEIIVMDSGKIIERGSDKELMSKDTRYKSL
                     QEMFNSANEWRVSNERVL"
     gene            1866..3587
                     /locus_tag="VXE25_002020"
     CDS             1866..3587
                     /locus_tag="VXE25_002020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019214631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0772418.1"
                     /translation="MKEFYKKRFALTDRGARNLSKATLASFFVYCINMPPAILLMIFA
                     QEVLENMGKSNGFYIVFSVLTLIAMYILLSIEYDKLYNTTYQESADLRIRTAENLSKL
                     PLSYFSKHDISDISQTIMADIEGIEHAMSHSIPKVGGMVLFFPLISVMMLAGNVKMGL
                     AVIIPSILSFIFIPLSKKYQVKGQNRYYDVLRKNSESFQENIEMQMEIKAYNLSKDIK
                     DDLYKKMEDSERVHLKAEVTTILTLSISSIFSFISLAVVIFVGVNLIINKEINSLYLI
                     GYLLAAMKIKDSLDASKEGLMEIFYLSPKIERLKEIQNQDLQEGDDYSLKKFDIDLKD
                     VEFAYNKDAKVLNGVSFKAKQGEVTALVGASGCGKTTILKLISRLYDYDKGQILIDGK
                     DIKEISTESLFNKVSIVFQDVVLFNQSIMENIRIGKQDASDEEVKRAAKLANCTDFIE
                     KMDKGFDTVIGENGAELSGGERQRLSIARAFLKDAPILILDEITASLDVNNEKKIQES
                     LNNLVKDKTVVIISHRMKSIENADKIVVLQNGRVESEGKHEELLQKSKIYKNLIEKTK
                     MAEEFIY"
     gene            3598..4182
                     /locus_tag="VXE25_002021"
     CDS             3598..4182
                     /locus_tag="VXE25_002021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000368966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MptD family putative ECF transporter S
                     component"
                     /protein_id="HEV0772419.1"
                     /translation="MDNKKLKVKDLVSIGVFGVIYFAFMFGVGMMGLIPILFLIYPTV
                     LAIVAGTVVMLFMAKVQKPWALFIFGMISPLVMFAAGHTYVVVVLSLIVMIIAELIRK
                     IGNYNSFKYNMLSYAIFSTWICSSLMQMLLAKEKYMEWSLMTMGKDYVDVLEKLITYP
                     HMALVALGAFLGGILGAYIGKALLKKHFEKAGIV"
     gene            4182..4877
                     /locus_tag="VXE25_002022"
     CDS             4182..4877
                     /locus_tag="VXE25_002022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001141947.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     protein EcfT"
                     /protein_id="HEV0772420.1"
                     /translation="MPTFSSNAPFNPNPISKILVIFITGLTVMHSINIRFELAIVCLI
                     GILLYLNGYKKTLFKWIILCGILYSLPNFMVLSELNPIVKMFLSIPIVIRMFILPFMA
                     ASFMIKTSDVGAIISSMDKLKISKNVSIPIAVMFRFFPSFKEEKKNIKMAMRVRGINF
                     KNPVKYLEYVSVPLLIISSNISDDIAKAAETKAIENPIAKTRYIRVKIQLIDFVYVLA
                     VAGLIVGGLIWLK"
     gene            4865..>5585
                     /locus_tag="VXE25_002023"
     CDS             4865..>5585
                     /locus_tag="VXE25_002023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002837029.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0772421.1"
                     /translation="MVEIKNLSLDYGEEHILDDISLSIAEGECVLFTGKSGNGKSSLI
                     NSINGLAVRYDNAKTKGKIIIDGKNIKNLELYQISMLVSTVFQNPKTYFFNVNTTLEL
                     LFYLENIGLAREEMDRRLKDMLEIFPIKNLLNRNIFNLSGGEKQILCIAASYIAGTKI
                     IVMDEPSSNLDIKSISVLAKMLKILKEKGISIIVAEHRIYYLMDIVDRVFLIDKGKLK
                     KTYTRSEFLKLDKNELNALSLR"
BASE COUNT         2011 a          724 c         1046 g         1804 t
ORIGIN      
        1 tagccttatt aattcaaaac tattgtatta gtaattataa cagatgtata atagaaaagc
       61 aatgatagat attatcaatt aagcgaattt atatctaaaa gggatattaa agaaaggaga
      121 tatgcttatg aagatttaca aaaaactatt tgcttatgtc caagataaga aatatcttgg
      181 ggttttggcc ataatttttt ctgctatatc tgctgcactt acagtatatg gatattattt
      241 aatctacaaa tttctagata agttaataat taattcaaac ttatccggtg cagagagtat
      301 agcattaaaa tctgttatta cactaacaag tggagcgata ttttattttg tctcaggaat
      361 gttttcacat atcttgggat ttaggcttga aacaaattta agaaaaaggg gaatcgatgg
      421 tctggaaaaa gcaagtttta ggttctttga cttaaatcca tctggtcaaa taagaaagat
      481 catagatgat aatgcagcac aaactcatca ggtggtagct cacatgattc cagatagctc
      541 tcaggcaata gtcacaccta tacttgtcct tgtactaggc tttatagtaa gtataagggt
      601 tggtataact ttgcttgctc ttactataat tggcggctta attttagggg cgatgatggg
      661 cgagcaagaa tttatgaaga tataccaaga agctctatct aaactaagtg ctgagactgt
      721 cgagtacgtt agaggaatgc aggttgtaaa aatatttaaa gcaaatgtag agtcttttaa
      781 aagcttttat aaggcgataa aagattactc aaagtatgct tatgattatt ccctatcttg
      841 taaaaggcct tatgttttgt atcaatggtt attttttgga ctgattgcaa ttttaattat
      901 tcctatagtt tattttatga ctagcttagc tagcgcaaag gtgattttac ttgagcttat
      961 catgatttta tttttatcag gagttctctt tgtttcattc atgagaatga tgtggtactc
     1021 catgtatatt tctcaaggaa attatgcagt agatacttta gaggcgcttt acgaagatat
     1081 gcaaaaagac aaattagtgc atggtaatgt caataatttt aaaaactata atatagaatt
     1141 tgagaatgtt agctttgctt ataatgataa agctgtcatt gaaaatttat cctttaattt
     1201 agaagaagga aagtcctacg cacttgtcgg ttcatctgga tcaggcaaat caacagtagc
     1261 aaaacttata tcaggttttt acaatgttaa taaaggaagc ataaagatag gcgggatagc
     1321 aataagtgaa tattctgacg aagccttaat taaagccatt tcctttgttt ttcaagattc
     1381 aaaattattc aagaagagca tttatgataa tgtagcttta gctaataaag atgcgacgaa
     1441 agatgacgtt atgagagcct taaaattagc aggatgcgat ttaatattag acaaattccc
     1501 agaaagagaa aatacaatca tagggtcaaa aggtgtttat ttatccggtg gagaaaaaca
     1561 aagaattgca attgctagag caattttaaa ggattccaaa attattatta tggatgaagc
     1621 atcagcatct attgacccag ataacgagtt tgagttgcaa aaagctttca aaaatcttat
     1681 gaaggataaa acagttatca tgattgcaca caggctatct acaattaaag accttgatga
     1741 aattattgtt atggatagtg gaaaaattat agaaagaggg tctgacaaag aattaatgtc
     1801 aaaagataca aggtataaga gcctgcaaga gatgtttaac agtgcgaatg aatggagggt
     1861 ttcaaatgaa agagttttat aaaaaaagat ttgctcttac agatagagga gcaagaaatt
     1921 taagtaaagc aacactggct tcatttttcg tttattgtat aaacatgcct cctgccatat
     1981 tacttatgat ttttgctcag gaagttttgg aaaatatggg caaaagcaat ggcttttata
     2041 tagtattctc agttttgact ttgatagcaa tgtatatttt gctttctatc gaatacgata
     2101 aattatataa cacaacctat caagaaagtg cagatttaag aataaggaca gcggagaatt
     2161 tatcaaaatt acctctatct tacttttcta aacatgacat ttccgacatt tcacaaacaa
     2221 tcatggctga tattgaaggc atagagcatg caatgagcca ctcaatacca aaggtgggcg
     2281 gcatggtact gtttttccca ttaatatctg taatgatgct agcgggcaat gtcaagatgg
     2341 gtttagctgt aattattcca tctattttaa gctttatatt tataccttta tctaaaaaat
     2401 atcaggttaa gggacagaat agatattatg atgtcttaag aaaaaactca gaaagctttc
     2461 aagaaaatat cgaaatgcaa atggagatta aagcatataa tttatcgaag gatattaaag
     2521 atgacttata taaaaaaatg gaagatagtg agagagtaca cttaaaggcg gaagtaacta
     2581 caattttaac tttgtctata tcttcaatat ttagctttat atctcttgct gttgtgatat
     2641 ttgtcggcgt aaatctaatt attaataaag agataaattc tctctacctt ataggatatt
     2701 tactagctgc tatgaagata aaagactctt tagatgcatc taaagagggc ttgatggaaa
     2761 tattttattt atcgcccaaa atagaaagat taaaagaaat tcaaaatcaa gatttacaag
     2821 aaggcgatga ctatagttta aaaaaatttg atattgatct aaaagatgtt gagtttgcct
     2881 acaataaaga cgcaaaagtt ttaaatggtg taagttttaa agctaagcag ggagaggtca
     2941 ctgctttggt aggtgcaagt ggctgcggta aaacaactat cttgaaactt atatcaagac
     3001 tttatgatta tgacaaggga caaatcttaa tcgatggcaa agatataaaa gaaatatcaa
     3061 cagaatctct ttttaataag gtctctatag ttttccaaga tgtggttctc tttaatcaaa
     3121 gcattatgga aaatattaga atcggaaagc aagatgcaag tgacgaagag gttaaaagag
     3181 cagcaaaact tgcaaattgc acagatttta tagaaaaaat ggataaaggt ttcgatacag
     3241 ttattggtga gaacggagct gagctatcag gaggagaaag acaaagatta tcaatagcca
     3301 gagccttctt aaaagatgcg ccgatattga tcttagatga gataacagca agccttgatg
     3361 ttaacaacga gaaaaagatt caagagtctt taaataattt agttaaagat aaaactgttg
     3421 taatcatttc acatagaatg aaatccatag aaaatgcaga caagatagta gttcttcaaa
     3481 acggaagagt agaaagcgaa ggtaagcatg aagagctttt acaaaaatca aaaatttaca
     3541 aaaatttaat agaaaagaca aaaatggcag aagaatttat ttattaggag gactacaatg
     3601 gataataaaa aattaaaagt aaaagattta gtaagcatcg gtgtttttgg cgtaatttat
     3661 tttgccttca tgtttggagt tggtatgatg ggcttgattc caatattgtt cttaatatac
     3721 ccgacagtat tagccatagt tgcaggaact gttgttatgt tatttatggc taaggttcaa
     3781 aagccatggg cactatttat atttggtatg atatcaccac ttgtgatgtt tgcagctggt
     3841 catacctacg tagttgtggt tttatcactt atagtaatga taatagcaga attaattaga
     3901 aagattggta attataattc atttaaatac aatatgcttt cttatgcaat cttcagcaca
     3961 tggatatgta gctctttaat gcaaatgctt ttagcaaaag aaaaatatat ggagtggtct
     4021 ttgatgacga tgggaaaaga ttatgttgat gtattagaaa agttaataac ttatcctcat
     4081 atggctttag tagccttagg tgctttctta ggaggaattc ttggagcata tataggcaag
     4141 gctctattga aaaaacactt tgaaaaagca ggcattgtat aatgcctact ttttcttcaa
     4201 atgctccctt taatcccaat ccgatctcta agatattagt catatttatc acaggcttaa
     4261 ctgttatgca tagcataaac atccgttttg agctggcaat tgtttgtctt attggtattt
     4321 tgctttattt gaatggatac aaaaaaacac ttttcaaatg gattatattg tgtgggatac
     4381 tttactcctt gcctaatttt atggtgctat ctgaattaaa ccctatagtt aagatgtttt
     4441 tgagtatacc tattgttatt agaatgttta ttttaccatt tatggcagca agctttatga
     4501 taaagacctc ggatgtaggc gcaataattt catcgatgga taagcttaag atttcaaaga
     4561 atgtatccat acctattgcg gttatgttta gattcttccc atcttttaag gaggagaaga
     4621 aaaacatcaa aatggctatg agagtaagag ggataaattt taaaaaccca gtcaaatatc
     4681 ttgaatatgt ttctgtgcca ctactcatta tatcatctaa tatatcagat gacattgcaa
     4741 aagcggcaga aacaaaggca atagaaaatc caattgccaa gaccagatac attcgcgtaa
     4801 agatacagct aattgatttt gtttatgttt tagcggttgc tggacttatt gtgggaggct
     4861 taatatggtt gaaataaaaa atttaagtct tgattatggt gaagagcata tattagatga
     4921 tatatcacta tccatagccg agggagagtg cgtgctattt acaggaaaaa gtggaaatgg
     4981 taagtcatct ttaataaatt caatcaatgg actagctgta aggtatgata acgcaaagac
     5041 aaagggcaaa ataattattg atggtaagaa tataaaaaat ttggaacttt atcaaatctc
     5101 aatgcttgtt tcaactgttt ttcaaaatcc taagacatat ttttttaatg tcaatacgac
     5161 attagaatta ttattttatt tggaaaatat cggtcttgca agagaagaga tggacaggcg
     5221 tttgaaggat atgcttgaga tattcccgat aaaaaatctt ttgaacagaa atatatttaa
     5281 tctatccggc ggtgaaaaac aaattctttg cattgcagct tcttatatag caggtacaaa
     5341 gattatagtt atggatgagc cttcatcgaa tttagatatt aaaagcataa gtgttttggc
     5401 aaagatgcta aagatattaa aagagaaagg cataagcata attgttgcag agcatagaat
     5461 ttattatttg atggacatag ttgaccgtgt atttttaata gataaaggaa agcttaaaaa
     5521 aacttatact agaagtgaat ttttaaagct agataaaaat gaattaaatg ctttaagttt
     5581 aagag
//
LOCUS       DAVLHC010000084         5446 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.085, whole genome shotgun sequence.
ACCESSION   DAVLHC010000084 DAVLHC010000000
VERSION     DAVLHC010000084.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 5446)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5446)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5446
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.085"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            256..327
                     /locus_tag="VXE25_002024"
     tRNA            256..327
                     /locus_tag="VXE25_002024"
                     /product="tRNA-Glu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:289..291,aa:Glu,seq:ttc)
     gene            579..2124
                     /locus_tag="VXE25_002025"
     rRNA            579..2124
                     /locus_tag="VXE25_002025"
                     /product="16S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00177"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00177"
     gene            2176..2248
                     /locus_tag="VXE25_002026"
     tRNA            2176..2248
                     /locus_tag="VXE25_002026"
                     /product="tRNA-Ala"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:2209..2211,aa:Ala,seq:tgc)
     gene            2373..5274
                     /locus_tag="VXE25_002027"
     rRNA            2373..5274
                     /locus_tag="VXE25_002027"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
     gene            5351..>5446
                     /gene="rrf"
                     /locus_tag="VXE25_002028"
     rRNA            5351..>5446
                     /gene="rrf"
                     /locus_tag="VXE25_002028"
                     /product="5S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00001"
BASE COUNT         1575 a         1086 c         1570 g         1215 t
ORIGIN      
        1 tatctctttc atgaaacact aagagattat agaaacaaac aaagtaaaga gaaacaagaa
       61 gaactagaac gcgtcttaag caatgaacga tttcgagggc gtcaaagagt attaagagac
      121 ttacgcattg tgtttaagga gtttactatc cgtacccact agtaagtcat gcaaaaaaaa
      181 tgaaaaaaat tagaaaaagt agttgacaaa gtttgaaaag gctgtataat agtaagagtt
      241 gaaaataaca actcaggtcc gttggtcaag gggttaagac accgcctttt cacggcggta
      301 acacgggttc gaatcccgta cggactatgg tatgttgcgt caggagcact tgatgaaaaa
      361 aagtttaaaa aaacttaaaa atcttcaaaa aagtgttgac aattgaaagt ggctgtgata
      421 tactaatata gttgtcgctt gagagaagca agtgacaaag acctttgaaa actgaacaag
      481 acgaaccaat gtgcagggcg ctacaacata agttgtagta ctgaacaatg aaaaaacaat
      541 aaatctgtca gtgacagaaa tgagtgagaa ctcaaacttt taatgagagt ttgatcctgg
      601 ctcaggacga acgctggcgg cgtgcctaat acatgcaagt agaacgctga aggaggagct
      661 tgcttctctg gatgagttgc gaacgggtga gtaacgcgta ggtaacctgc ctggtagcgg
      721 gggataacta ttggaaacga tagctaatac cgcataagag tggatgttgc atgacatttg
      781 cttaaaaggt gcacttgcat cactaccaga tggacctgcg ttgtattagc tagttggtgg
      841 ggtaacggct caccaaggcg acgatacata gccgacctga gagggtgatc ggccacactg
      901 ggactgagac acggcccaga ctcctacggg aggcagcagt agggaatctt cggcaatgga
      961 cggaagtctg accgagcaac gccgcgtgag tgaagaaggt tttcggatcg taaagctctg
     1021 ttgtaagaga agaatgagtg tgagagtgga aagttcacac tgtgacggta tcttaccaga
     1081 aagggacggc taactacgtg ccagcagccg cggtaatacg taggtcccga gcgttgtccg
     1141 gatttattgg gcgtaaagcg agcgcaggcg gttagataag tctgaagtta aaggctgtgg
     1201 cttaaccata gtaggctttg gaaactgttt aacttgagtg caagagggga gagtggaatt
     1261 ccatgtgtag cggtgaaatg cgtagatata tggaggaaca ccggtggcga aagcggctct
     1321 ctggcttgta actgacgctg aggctcgaaa gcgtggggag caaacaggat tagataccct
     1381 ggtagtccac gctgtaaacg atgagtgcta ggtgttagac cctttccggg gtttagtgcc
     1441 gtagctaacg cattaagcac tccgcctggg gagtacgacc gcaaggttga aactcaaagg
     1501 aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga
     1561 accttaccag gtcttgacat ccctctgacc gctctagaga tagagctttc cttcgggaca
     1621 gaggtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc
     1681 cgcaacgagc gcaaccccta ttgttagttg ccatcattta gttgggcact ctagcgagac
     1741 tgccggtaat aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc
     1801 tgggctacac acgtgctaca atggctggta caacgagtcg caagccggtg acggcaagct
     1861 aatctcttaa agccagtctc agttcggatt gtaggctgca actcgcctac atgaagtcgg
     1921 aatcgctagt aatcgcggat cagcacgccg cggtgaatac gttcccgggc cttgtacaca
     1981 ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac cgtaaggagc
     2041 cagccgccta aggtgggata gatgattggg gtgaagtcgt aacaaggtag ccgtatcgga
     2101 aggtgcggct ggatcacctc ctttctaagg ataaggaact gcgcattggt cttgtttagt
     2161 cttgagaggt cttgtggggc cttagctcag ctgggagagc gcctgctttg cacgcaggag
     2221 gtcagcggtt cgatcccgct aggctccatt ggtgagagat caccaagtaa tgcacattga
     2281 aaattgaata tctatatcaa atagtaacaa gaaaataaac cgaaaacgct gtagtattaa
     2341 taagagttta tgactgaaag gtcagaaaat aaggttaagt taataagggc gcacggtgga
     2401 tgccttggca ctaggagccg acgaaggacg tgacaaacga cgatatgcct tgggtagctg
     2461 taagtaagcg atgatccagg gatttccgaa tgggggaacc caacaggtag tacctgttac
     2521 ccacatctgt taaggatgtg aggaggaaga cgcagtgaac tgaaacatct aagtagctgc
     2581 aggaagagaa agcaaaagcg attgccttag tagcggcgag cgaaacggca ggagggcaaa
     2641 ccgaagagtt tactcttcgg ggttgtagga ctgcaatgtg gactcaaaga ttatagaaga
     2701 atgatttggg aagatcagcc aaagagagta atagcctcgt atttaaaata gtctttgtac
     2761 ttagcagtat cctgagtacg gcgggacacg tgaaatcccg tcggaatctg ggaggaccat
     2821 ctcccaaccc taaatactcc ctagtgaccg atagtgaacc agtaccgtga gggaaaggtg
     2881 aaaagcaccc cgggagggga gtgaaataga acctgaaacc gtgtgcctac aacaagttcg
     2941 agcccgttaa tgggtgagag cgtgcctttt gtagaatgaa ccggcgagtt acgttatgat
     3001 gcgaggttaa gttgaagaga cggagccgta gggaaaccga gtctgaatag ggcgccttag
     3061 tatcatgacg tagacccgaa accatgtgac ctacccatga gcaggttgaa ggtgcggtaa
     3121 gacgcactgg aggaccgaac cagggcacgt tgaaaagtgc ttggatgact tgtgggtagc
     3181 ggagaaattc caaacgaact tggagatagc tggttctctc cgaaatagct ttagggctag
     3241 cgtcgacatt agagattctt ggaggtagag cactgtttgg gtgaggggtc catcccggat
     3301 taccaatctc agataaactc cgaatgccaa tgaattatgg tcggcagtca gactgcgagt
     3361 gctaagatcc gtagtcgaaa gggaaacagc ccagaccacc agctaaggtc ccaaaataat
     3421 tgttaagtgg aaaaggatgt ggggttgcac agacaactag gatgttagct tagaagcagc
     3481 tattcattca aagagtgcgt aatagctcac tagtcgagtg accctgcgcc gaaaatgtac
     3541 cggggctaaa acaatttacc gaagctgtgg atacctttat aggtatggta ggagagcgtt
     3601 ctatgtgtga tgaaggtata ccgtgaggag tgctggaacg catagaagtg agaatgccgg
     3661 tatgagtagc gaaagacagg tgagaatcct gtccaccgta agactaaggt ttccagggga
     3721 aggctcgtcc gccctgggtt agtcgggacc taaggagaga ccgaaaggtg tatccgatgg
     3781 acaacaggtt gatattcctg tactagagta tgtagtgatg gagggacgca gtaggctaac
     3841 taaagcagac gattggaaga gtctgtctaa gcagtgaggt gtgaattgag tcaaatgctt
     3901 aattctataa cattgagctg tgatggggag cgaagtttag tagcgaagtt agtgacgtca
     3961 cactgccaag aaaagcttct agcgtttaaa catactctac ccgtaccgca aaccgacaca
     4021 ggtagtcgag gcgagtagcc tcaggtgagc gagagaactc tcgttaagga actcggcaaa
     4081 atgaccccgt aacttcggga gaaggggtgc tgactttaag tcagccgcag tgaataggcc
     4141 caagcaactg tttatcaaaa acacagctct ctgctaaatc gtaagatgat gtataggggg
     4201 tgacgcctgc ccggtgctgg aaggttaaga ggagtgctta gcgtaagcga aggtatgaat
     4261 tgaagcccca gtaaacggcg gccgtaacta taacggtcct aaggtagcga aattccttgt
     4321 cgggtaagtt ccgacccgca cgaaaggcgt aatgatttgg gcactgtctc aacgagagac
     4381 tcggtgaaat tttagtacct gtgaagatgc aggttacccg cgacaggacg gaaagacccc
     4441 atggagcttt actgcagttt gatattgagt gtctgtacca catgtacagg ataggtagga
     4501 gtctaagaga tcgggacgcc agtttcgaag gagacgctgt tgggatacta cccttgtgtt
     4561 atggccactc taacccagat aggtgatccc tatcggagac agtgtctgac gggcagtttg
     4621 actggggcgg tcgcctccta aaaggtaacg gaggcgccca aaggttccct cagaatggtt
     4681 ggaaatcatt cgcagagtgt aaaggtataa gggagcttga ctgcgagagc tacaactcga
     4741 gcagggacga aagtcgggct tagtgatccg gtggttccgt atggaagggc catcgctcaa
     4801 cggataaaag ctaccctggg gataacaggc ttatctcccc caagagttca catcgacggg
     4861 gaggtttggc acctcgatgt cggctcgtcg catcctgggg ctgtagtcgg tcccaagggt
     4921 tgggctgttc gcccattaaa gcggcacgcg agctgggttc agaacgtcgt gagacagttc
     4981 ggtccctatc cgtcgcgggc gtaggaaatt tgagaggatc tgctcctagt acgagaggac
     5041 cagagtggac ttaccgctgg tgtaccagtt gtcttgccaa aggcatcgct gggtagctat
     5101 gtagggaagg gataaacgct gaaagcatct aagtgtgaaa cccacctcaa gatgagattt
     5161 cccatgatta tatatcagta agagccctga gagatgatca ggtagatagg ttagaagtgg
     5221 aagtgtggcg acacatgtag cggactaata ctaatagctc gaggacttat ccaaagtaac
     5281 tgagaatatg aaagcgaacg gttttcttga tttgaataga tattcaattt tgagtaggta
     5341 ttactcagag ttaagtgacg atagcctagg agatacacct gtacccatgc cgaacacaga
     5401 agttaagccc tagaacgccg gaagtagttg ggggttgccc cctgtg
//
LOCUS       DAVLHC010000085         5195 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.086, whole genome shotgun sequence.
ACCESSION   DAVLHC010000085 DAVLHC010000000
VERSION     DAVLHC010000085.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 5195)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5195)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5195
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.086"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            74..934
                     /locus_tag="VXE25_002029"
     CDS             74..934
                     /locus_tag="VXE25_002029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerophosphodiester phosphodiesterase family
                     protein"
                     /protein_id="HEV0772422.1"
                     /translation="MNPLKECYEKNGILIAAHRGTNGGNILQNTSKAYLNSIRHNADM
                     FEVDVIRSKDGEFFAFHDGQEPLVFGEKIDIRTLSSEEIQRKECFNSLNEPILQKIEK
                     ISDVLKNFEGQSLINIDRSWFYWDTFLDKLKTYPSLNQVLLKSPVKKELLEMLRDSGL
                     NVMYMPIIKTIEELDFVLSFEGINTVAVELVFQDLENPIISKKIIDDLHEKGLLIWVN
                     ALTLSDSIILSAKIDDDTAIAHDGESWGKLVSIGFDIIQTDWPLLLYQYLVEKNKKIK
                     IKENYHVQKL"
     gene            918..1979
                     /locus_tag="VXE25_002030"
     CDS             918..1979
                     /locus_tag="VXE25_002030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000475757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HEV0772423.1"
                     /translation="MFKNFKKIAFTSSLILLAACSNNASNTNQSTDEGSVDKSQEIVI
                     YTNSASNGRADWLQTKASEQGYNLRLVDISGGELADRLIAEKNNAVADMVIGLNKLEF
                     NRIKAEKLLVKYSPKWADEVDSSLGDSEGYYSPIVNQPLVLIGNKDAKMPSDWTDFTD
                     SSYKGKYGISKLSTGTSKNIFASIVSRYKDEKGELGISDEGWKVAKAYLKNAHVYAEG
                     EDYISSIMDNNNDLKYSMMWGSGVLQNQKEREYKFQVMSPKVGVPYVTEQVGILNTSK
                     KQALLKEFVDWFGSSELQKEWSDKFGSIPANKKALEQAKDELKQFANSVKPQELDWEF
                     IGKNIDSWIEKAQLEFVEQ"
     gene            1996..3000
                     /locus_tag="VXE25_002031"
     CDS             1996..3000
                     /locus_tag="VXE25_002031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0772424.1"
                     /translation="MITFKDIQIKYNDFIAIDNLNLTINEGEFFTFLGPSGCGKSTTL
                     RALVGFLEPSQGQILVDNQDITNLDPEKREIGIVFQSYALFPTMTVFDNIAFGLKVKK
                     VSPEIIKAKVHEIAKKINISDEQLNRNISELSGGQQQRVALARALVLEPKILCLDEPL
                     SNLDAKLRVSLRKELKRLQKELGITTLYVTHDQEEALTLSDRIAVFNNGFIEQVGTPY
                     DIYNQSATQFVCDFIGSINKISQEVLKKLQGENKYFKETEGYIRLERVKLEKTSPQDL
                     SITGVISDIEFNGVLIKYKVDLSNSESIHIIEKNDGLSRHIIKEKVTMYINPRDIMQF
                     "
     gene            3012..4706
                     /locus_tag="VXE25_002032"
     CDS             3012..4706
                     /locus_tag="VXE25_002032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HEV0772425.1"
                     /translation="MRKSLNWKDCLIRLGVLWLIFALIIYPNIELLSGVFYKNGSFTL
                     EAFNKIIHSQRAMSSIFNSFILAISMVFTVNIVGTLIVLLTEYWDIRGSKILKLGYMS
                     SLVYGGIVLATGYKFVYGANGLVTKTLSSIIPGLAPNWFQGFGAVLFIMTFACTSNHI
                     MFLTNAVRSVDYHTIEAAKNMGASPLKVFFSVVFPTFKPTLFALTILTFLTGLSAVSA
                     PLIVGGKDFQTINPLIISFAKTTSSRDLAALLAIMLGLATILLLTLLNHVEKGGNYVS
                     VSKTKASIKKQIISSPLWNTLAHIVAYVLFAIYMLPIVLIILYSFTDSLTIKTGTLDL
                     SKFTLANYANLFTDAQSFRPYLVSVVYAILAAVIATIIAIVISRIVHKNKSKFDKFFE
                     YGALIPWILPGTLIALGLMFTYNIPHLILFNLVLVGTVIILLIAYTIQKLPFSYRMIR
                     AVFFSIDNDMEEAARSMGASSFYTMVRVIIPYILPVVLSVVVLNFNSLLSDYDLSVFL
                     YHPLFQPLGIVIKQSTDETATLNAQAMMFVYSVILMIMSSAALYLSSLFQGKRGKR"
     gene            4708..>5195
                     /locus_tag="VXE25_002033"
     CDS             4708..>5195
                     /locus_tag="VXE25_002033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001054457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MgtC/SapB family protein"
                     /protein_id="HEV0772426.1"
                     /translation="MNLSYELSIWEILLRCFLAILFGGIVGYERGVKNQAAGIRTYLL
                     VCLGTCVVMMTNQFITSRYGSGDPSRMGAQVISGLGFLGAGTIMVTNQKVKGLTTAAG
                     LWSSATIGLAIGIGFYEGAILAGVVLIAVLTLFTPLKDYLNSKTKIADYYLVFSSLEG
                     YNR"
BASE COUNT         1766 a          733 c          957 g         1739 t
ORIGIN      
        1 tccaacttat ctattgacac gttccaagaa atcggataca atgtaattaa caataaagat
       61 aggagaaaat aatttgaatc cattaaaaga atgctatgaa aaaaacggta tactaattgc
      121 agcacaccgt ggtacaaacg gaggaaatat attacaaaac acatcaaaag cctatttgaa
      181 ttccatacgc cataacgcag atatgtttga ggttgatgta attcgttcaa aagatggaga
      241 attttttgca tttcacgatg ggcaagaacc tttagtattt ggtgaaaaaa ttgatattag
      301 aactttgagt tctgaagaga tccaaagaaa ggaatgtttt aattcactga atgaacccat
      361 attacaaaag attgaaaaaa tttctgatgt attaaaaaat tttgagggac aatctttaat
      421 aaatatagat agaagttggt tttactggga taccttccta gataagttaa aaacatatcc
      481 atctttgaat caagttcttt taaaatcacc tgtaaaaaaa gaattattgg aaatgcttag
      541 agactctggt ttgaatgtta tgtatatgcc aattatcaaa acaattgaag agttagattt
      601 tgttctctca tttgaaggaa taaatacagt agctgtcgaa cttgtattcc aagatttaga
      661 aaatccaatc ataagtaaga aaataattga tgatttacat gaaaaaggat tacttatttg
      721 ggttaatgct ttaaccttaa gtgattcaat tattctttcg gctaagattg atgatgatac
      781 agctattgct catgatggcg aatcttgggg gaaattggtt tcaataggat ttgatattat
      841 tcaaacagat tggccattat tactttatca atatctagtt gaaaaaaata aaaaaataaa
      901 aataaaggag aactatcatg ttcaaaaact ttaaaaagat tgcattcact tcttcactaa
      961 ttttacttgc tgcttgctca aacaatgctt caaatacaaa tcagtctact gatgaaggaa
     1021 gtgttgataa atctcaagaa attgtaatct atacaaattc ggcttctaat ggacgtgcag
     1081 attggttaca aactaaagca tcagagcaag gatacaatct tcgtttggta gatatttcag
     1141 gtggagaact agctgaccgt ttgattgcag aaaagaataa tgctgtggct gatatggtaa
     1201 ttggattaaa taaattagaa tttaaccgta ttaaagctga aaaacttctt gtaaaatact
     1261 caccaaaatg ggctgatgaa gtagatagct ctttgggaga ttctgaaggg tattattcac
     1321 caattgtaaa tcaaccatta gttttgattg gtaataaaga tgctaaaatg ccatccgact
     1381 ggacagattt tactgattca tcttataaag gtaaatatgg tatttcaaaa ttaagtacag
     1441 gtacatctaa gaacatcttt gcaagtattg tttcgagata taaagatgaa aaaggtgagt
     1501 taggaatatc tgatgaaggt tggaaagttg caaaagctta ccttaaaaat gcacacgttt
     1561 atgcagaagg tgaagactat atctcttcaa ttatggataa taataatgat ctaaaatata
     1621 gtatgatgtg gggatctggt gttctacaaa atcaaaaaga acgtgaatat aaattccaag
     1681 taatgtcacc aaaagttggt gttccttatg taactgaaca agttgggatt ttaaatacaa
     1741 gtaagaagca agcattatta aaagaatttg tagattggtt tggctcttca gaacttcaaa
     1801 aagaatggtc tgataaattt ggttcaattc cagctaataa aaaagctcta gagcaagcaa
     1861 aagatgaact caaacagttt gctaatagtg ttaaaccaca agaacttgac tgggagttta
     1921 tcgggaaaaa catcgattct tggattgaaa aagcacagct tgaatttgtt gaacagtaat
     1981 agttaggatt aagtgatgat tacatttaag gatattcaaa ttaagtataa tgattttatt
     2041 gccatcgata atctcaattt aacaatcaat gagggagagt ttttcacatt tttaggacca
     2101 agtggttgtg ggaaatcaac aactcttcgt gcactagttg gatttttgga gccttcacag
     2161 gggcaaatac tagttgataa tcaagatatt acgaatttag atccggaaaa acgcgaaatt
     2221 ggtattgtgt ttcaaagtta tgcattattc ccaacaatga ctgtttttga taatattgct
     2281 tttggtctaa aagttaaaaa agtttctcct gaaattatta aagctaaagt tcatgaaatt
     2341 gcgaaaaaaa ttaatatctc agacgagcaa ctaaaccgaa atatttctga attatcaggg
     2401 ggacaacaac agcgtgtagc tttagcacgt gcattagtat tagaaccaaa aattctttgt
     2461 ttggatgaac cgttatcaaa cctagatgcc aaactacgag tttcgttgag aaaagaattg
     2521 aaacgattgc aaaaagaact aggaatcact actctttatg tcacacatga tcaagaagaa
     2581 gcattaacat tatcagatag gattgctgtg tttaataatg gatttattga gcaagttggc
     2641 acgccgtatg atatttataa tcaatccgca actcaatttg tctgtgattt tattggctca
     2701 atcaataaaa ttagccaaga agttcttaaa aaattacaag gcgagaataa atactttaaa
     2761 gaaactgaag gatacatacg cttagagcgt gttaagttag agaaaacttc acctcaagat
     2821 ttatctataa caggggtaat tagtgatatt gagtttaatg gtgtacttat taagtataaa
     2881 gtagacttgt cgaatagtga aagtattcat attatcgaaa agaatgatgg actatcacgt
     2941 catataatca aagaaaaagt cactatgtac attaatccgc gtgatataat gcaattttaa
     3001 ggagattgtg catgagaaag agtctaaact ggaaagattg tctcataaga ttaggagttt
     3061 tatggctaat ctttgccctg attatttatc caaatattga acttttgtct ggagtgtttt
     3121 ataaaaatgg ttcatttact ctagaggcat tcaataagat tatacactct cagagagcga
     3181 tgagtagtat atttaatagc tttattttgg cgatttcaat ggtctttact gtaaatattg
     3241 ttgggacatt gattgttcta ctcacagagt actgggatat taggggttca aaaatactta
     3301 aattaggtta tatgagctct ctagtatatg gaggaattgt attagcgaca ggatataaat
     3361 ttgtttatgg cgctaatggt cttgtaacta aaacgctctc aagtataatt ccaggtcttg
     3421 cccctaactg gtttcaagga tttggtgcag tattgtttat tatgacattt gcttgtacct
     3481 caaatcacat aatgttttta acaaatgcag ttcgtagtgt tgattatcat acaattgagg
     3541 cagctaaaaa tatgggtgca agtcctttaa aagttttctt tagtgtggtt tttccaactt
     3601 ttaaacctac gttatttgcc ttaaccatct taactttttt gacaggtctt tcagcagttt
     3661 ctgctccttt gatagtaggg gggaaagatt ttcaaactat taacccattg attatcagtt
     3721 tcgctaaaac tacaagttcg agagatttag cagctttact agctatcatg ttaggtttag
     3781 caactattct attattgaca cttttgaatc atgtcgaaaa aggaggtaat tatgtatctg
     3841 tttcgaaaac caaggctagt attaagaagc agataatttc ttctccatta tggaatactc
     3901 ttgctcacat tgttgcgtat gtattgtttg caatctatat gttaccaata gttttgataa
     3961 ttctatactc gtttacagac tcgttgacga tcaagacggg aactttagat ctatctaaat
     4021 ttacgttagc gaactatgct aatttattta cagatgctca atcatttcgt ccttacctag
     4081 tcagcgttgt ttatgcaatt ttagctgcgg taattgctac aattatagca atagtaattt
     4141 cacgtattgt acataaaaac aagagtaagt tcgataaatt ctttgagtat ggtgcactga
     4201 taccatggat attgccaggt acattgattg cactaggatt aatgttcact tataatatac
     4261 ctcatttaat actatttaat ttagttttag taggaacagt aattatttta cttattgcat
     4321 atactattca aaaattacca ttttcttata gaatgattcg ggctgtattt ttcagtatag
     4381 ataatgatat ggaagaagct gcacgtagta tgggtgcatc tagtttctac actatggtgc
     4441 gagttattat accgtatatt ttaccagtcg tattatcagt agttgtgtta aactttaatt
     4501 ctttattatc tgactatgac ttatctgtat tcttgtacca tccacttttc caaccattgg
     4561 gaatcgttat taaacagtct actgatgaaa cagcaacttt aaatgcacag gcaatgatgt
     4621 ttgtttattc tgtaatttta atgattatgt ctagtgcagc tctttattta tcaagcctat
     4681 tccaaggtaa acgaggtaag agataatatg aatctttcat acgaactgag tatttgggaa
     4741 atacttctta ggtgcttttt agcgattctt ttcggtggca ttgttggcta tgagcgagga
     4801 gtcaaaaacc aagcagcagg gattagaacc tacttactag tttgtttggg aacttgtgtt
     4861 gtaatgatga caaatcagtt catcactagt cgttatggta gcggtgatcc tagtcgaatg
     4921 ggagcccaag taattagtgg cttgggtttc ctaggggcag gaacaatcat ggtaactaat
     4981 caaaaagtta aaggtttaac aacagcagct ggattatggt cttcagcaac tattggttta
     5041 gctataggca ttggttttta tgaaggtgct attttagccg gagttgtact catagcagtt
     5101 ttaactctat ttactcctct taaagattat ttaaactcga aaactaaaat tgctgattac
     5161 tacttggttt ttagttcttt agaaggttat aatcg
//
LOCUS       DAVLHC010000086         5115 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.087, whole genome shotgun sequence.
ACCESSION   DAVLHC010000086 DAVLHC010000000
VERSION     DAVLHC010000086.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 5115)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5115)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5115
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.087"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            281..1285
                     /locus_tag="VXE25_002034"
     CDS             281..1285
                     /locus_tag="VXE25_002034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001282846.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trypsin-like peptidase domain-containing
                     protein"
                     /protein_id="HEV0772427.1"
                     /translation="MNASFRGSASFIRDNVLVTAAHVVYDRDSRTEADSVYVIPAATP
                     NENPVGKIKVKEVRYLKEFQNTASNELTTYDLAVLILEEPIGAQLGTLGLPNNLGNLS
                     GTGATITGYPAVNSAKQMYTDSKDIVKDTGDFLMYQIDTLGGASGAGVYDSSFRLIGV
                     HVSGSSAGQMNSAVKLNEKALSFIYSVIQGHSIDGWKLISGTWYYYKNSTKQTGWQKI
                     NDTWYYLDASGKMRTDWEKVNGKWYYFESSGSMATGWKYVRGNWYYLDNKNGDMKTGW
                     YKDGSTWYYLDPTNGNMKKGWIKVGGNWYYLNSSGAMVTGSQTIDGKVYNFASSGEWI
                     "
     gene            1304..2284
                     /locus_tag="VXE25_002035"
     CDS             1304..2284
                     /locus_tag="VXE25_002035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698047.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase family
                     protein"
                     /protein_id="HEV0772428.1"
                     /translation="MKLLKKTMQVGLTAFFFGLLATNTVFADTTGGQFVDKDNRKYYV
                     KDDHKAIYWHKIDGKTYYFGNKGEMVVGWQYLEIPGTGYRDNLLDNQPVNEIGLQHKW
                     YYFGQDGSLQEYVGWKELDAKDSLNVGKEYGEPFEGPEVLKYANYYFDKDHSLKTGWF
                     YDQSNWYYLAKTGYLGKDYLGGERRAGWIYDGSSWYYLDTTTAAMQTGWQYLGNNWYY
                     LRSSGAMATGWMKDASTWYYLDGQNGDMKTGWAYVGNSWYYLRSSGAMSTGWMKDGST
                     WYYLNASNGDMKTGWFQVNGKWYYAYGSGALAVNTTVGGYYVNYNGEWVK"
     gene            complement(2450..2656)
                     /locus_tag="VXE25_002036"
                     /pseudo
     CDS             complement(2450..2656)
                     /locus_tag="VXE25_002036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006149662.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ImmA/IrrE family metallo-endopeptidase"
     gene            3072..4661
                     /locus_tag="VXE25_002037"
     CDS             3072..4661
                     /locus_tag="VXE25_002037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014334739.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HEV0772429.1"
                     /translation="MISRIILQNFKRYQNVDFTCNSEVNIFVGENGAGKSTLLYGIGL
                     VLSGSHSQIERSSLSSIINQEAILEFMGTRDINQLPEVFIEIYFDELSTEISSNFNIE
                     GKHNSQKIKAFGLSLKIIPNQDYIAEITSVLNDSKWTVFPFEFYRVEFLTFSGKTYSS
                     YNKPYKFLHSMINTSLIDTQQEIQKRIHEVYLDNISAENRAKVNHQYRINSFNFLKTL
                     RKDELLKENASEFQLHFDESENSFRNSVSAVKNGVDIKNLGQGEKVLLGVENAYSHLK
                     ETVKILLIEEPENHLSFQNLQKLVRMLSSNTGVQVFIGTHSNMIASRLGVDNLLFLDN
                     GQISKLKGLKKDTVRFFKKSTNQNLLNFSLGKKIILVEGNAEYILVEKFFEILHSKKP
                     EEFNVSIISVDGLSFERYLEIATNFTDKKVVVITDNDGDYESKVQSKYSSYQQFQNIK
                     VSSDLDNDNRTFEICIYNCNSDLLESSGLTKSNDLLEYMLREKAEFALRLLEQMETDN
                     IREKFIIPNYIKEAIEWIIKD"
     gene            4643..>5115
                     /locus_tag="VXE25_002038"
     CDS             4643..>5115
                     /locus_tag="VXE25_002038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810280.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA helicase"
                     /protein_id="HEV0772430.1"
                     /translation="MDNKRLIHAVAGSGKTTKIIETIDPQKRNLILTYTETNQNTIRA
                     KLIEKFGYIPESTFIFGVFESLYSFCLVPYLGKRPKGINFDYKTQGKFDKTAIDNTGR
                     IVQNQLSKSLLRGSLIYKRKEIRFDNSYLDRIDKFFDCIYVDECQDFESDDFDWL"
BASE COUNT         1776 a          642 c          988 g         1709 t
ORIGIN      
        1 tatttcaatt attgcgagta ctttattggc tagccagttg tcgacagtat ctgctttgac
       61 tgttatttct agtacaggtg aagaatatga ggtaagtgaa acattacaag agagtccagg
      121 aactaataat ttttcacttc ccgatatttc accgacttat ggtaaatatt atacaaatca
      181 gtcagaagtc attattggca acaatgattt agttaagatt gggaatactt tacagtatcc
      241 ttattctaca tcagcttacg taaaagcaga atttaatagt atgaatgcta gttttagagg
      301 cagtgctagt ttcataagag ataatgtttt ggttacagca gctcatgttg tttatgatcg
      361 tgattctaga acagaggcgg attctgtata tgttatccct gcggctactc cgaacgaaaa
      421 tcctgtagga aaaataaagg taaaagaagt tcgttatcta aaagaatttc aaaacacagc
      481 ttcaaatgag cttactacgt atgatttagc agttttgatt ttggaagaac caattggcgc
      541 tcaattaggt acactaggtc ttccgaataa tctagggaat ctttcaggta caggggctac
      601 tattactgga tatcctgctg taaatagtgc taagcaaatg tatactgact ctaaggatat
      661 tgtaaaagat actggagatt ttctaatgta tcaaatagat actctaggag gtgctagtgg
      721 agctggcgta tatgacagca gttttagatt gattggtgtt catgtgtctg gtagttctgc
      781 tggacagatg aattctgctg ttaagttaaa tgaaaaggct ttatcattta tctactctgt
      841 tattcaagga cattctattg atggttggaa attgattagt ggtacatggt actattataa
      901 gaacagtact aaacaaacag gttggcagaa aataaatgat acttggtact atctagatgc
      961 ttcaggtaag atgcgtacag attgggaaaa agtaaatgga aaatggtatt actttgaatc
     1021 atctggttcg atggcaacag gttggaaata tgtacgaggc aactggtatt acttagataa
     1081 taaaaatggt gatatgaaga ctggttggta taaagatggt tcaacatggt actatctaga
     1141 tcctactaat ggaaacatga aaaaaggttg gataaaagta ggaggaaact ggtattatct
     1201 aaattcaagt ggagcaatgg ttacaggtag ccaaactatc gatggtaaag tttataattt
     1261 cgcttcatct ggtgagtgga tctaatattg gaggggtata taaatgaaac ttttgaaaaa
     1321 aactatgcaa gttggactaa cagcattttt ctttggtttg ttagctacaa atacagtatt
     1381 tgcagatacc acaggtggcc aatttgttga taaggacaat agaaaatatt atgtaaaaga
     1441 tgatcataaa gcaatctatt ggcataaaat agacggaaaa acttactatt ttggtaataa
     1501 aggagaaatg gtagttggat ggcaatactt agaaattcct ggaacaggtt atcgtgataa
     1561 tttattagat aaccaaccag ttaatgaaat aggccttcaa cacaagtggt actattttgg
     1621 acaagatgga agtctccaag aatatgttgg ttggaaggaa ttagatgcta aggattcatt
     1681 aaatgttggc aaagagtatg gtgaaccatt tgaaggtcct gaagttctta aatatgcaaa
     1741 ttattacttt gataaagatc attctttaaa gacaggttgg ttttatgatc aatccaactg
     1801 gtactactta gcaaaaacag gttatttagg aaaagactat cttggtggtg aaagacgtgc
     1861 aggttggata tatgacggtt caagctggta ttatctagat acaacaactg ctgcaatgca
     1921 aacaggatgg caatatctag gtaataactg gtattatctc cgttcatcag gtgctatggc
     1981 aactggttgg atgaaagatg cttcaacttg gtattatcta gatggtcaaa atggtgatat
     2041 gaagacaggt tgggcttatg ttggcaacag ttggtactac cttcgttcat caggtgcaat
     2101 gtctactggt tggatgaaag atggttcaac ttggtactac ctaaatgcaa gtaatggaga
     2161 tatgaagaca ggctggttcc aagtcaatgg taaatggtac tatgcctatg gttcaggtgc
     2221 tttagctgtt aataccacag taggtggtta ttacgtaaac tacaacggtg aatgggttaa
     2281 gtaatgaagg ctaatgttaa actatagttg atacttaaca tagtaaaaga gataatcaga
     2341 gtgtgattct ctcttttgta atttaaaatg attttaagaa agtttttata tgtgtttgaa
     2401 aaattgtata atctatgtga tggattaaat ttctacaagt tttatagagt caaaaaataa
     2461 cactatcatc agataatgtt atttttttgt tatcattata aaagtgttta gctatttctt
     2521 ttacatagtt ttcatatttt gctggaattt ctgcatttga aatatagttt tgataattaa
     2581 aactttcatc aattgggtat tcactattta ctagactcat aaaatcaagg attcttcttt
     2641 tttcagcatc agaatcttaa ttttttgaag agagctgaag ataggggatc ataatcttgt
     2701 atactgattc aaaatatgtt gttggaacat caagtgttct tgcaagagca gaatgagttt
     2761 tttgatctgg aacggattta ctactttacc acttgttgta tgaagttcta ttgattttta
     2821 atagattaga tagctcagat taggaatagt gtttatctat ttggtgttct ttaagacgaa
     2881 tactagaaaa tataagctaa agctcctatt gctttattat gcaacaatta tgtcaaaatc
     2941 tttttaagat gcaagaataa agcaatattc atcttatctg taattacaat tttgaaaaat
     3001 taacaccatt tatgtgatat aatattaata gataactatt caaactaata tgcgaggttt
     3061 aggtagtctg tatgatatca agaataatat tacaaaactt taaacgttat cagaatgttg
     3121 attttacttg taattctgaa gttaatattt ttgttgggga gaacggtgct gggaaatcaa
     3181 ctctattata cggaattggt ttagtgctga gtggtagtca cagtcaaatt gaaagaagta
     3241 gtttgtctag tatcattaat caagaagcga ttttagaatt tatgggtaca agggatataa
     3301 atcagctccc tgaggtcttc attgagattt attttgatga attaagtact gaaatttcct
     3361 ctaacttcaa tattgaaggg aaacataact ctcaaaaaat caaagctttt ggactttcat
     3421 taaaaataat tcccaatcaa gattatatag ctgaaattac ttctgtctta aatgatagta
     3481 aatggacagt ctttccattt gagttttata gagttgaatt tttgacattt tcagggaaaa
     3541 cctattcctc ttacaacaaa ccatataagt ttctacattc aatgataaat acaagtctta
     3601 ttgatacaca acaagaaatt caaaaacgta ttcatgaggt atatttggat aatatatcag
     3661 ctgagaatag agcaaaagtt aatcatcaat acaggataaa ttcatttaat tttttaaaga
     3721 ctttaaggaa ggatgaactg ttgaaggaga atgcttcaga attccaactt cattttgacg
     3781 aatcagaaaa ttcatttaga aattcagtat cagctgtaaa aaatggtgta gatataaaaa
     3841 atttagggca aggagaaaag gtattattag gtgttgaaaa tgcatacagt catctcaagg
     3901 aaacggttaa aatactactt attgaggaac ctgagaatca tttgagcttc caaaacctcc
     3961 agaaattggt tagaatgcta agctcaaata caggtgttca agtttttatt gggactcatt
     4021 caaatatgat tgcttcaaga ttgggtgtag acaatcttct ttttttagat aatggtcaga
     4081 tatctaaact taaaggtttg aaaaaagata ctgtaagatt tttcaagaaa tctactaatc
     4141 aaaatttatt gaacttctct ctaggtaaga agataattct tgttgagggg aatgctgagt
     4201 atattttagt agagaagttt ttcgaaatac tccactccaa aaagcctgaa gaatttaatg
     4261 tatcaattat ttctgtagat ggattaagtt ttgagaggta tttagaaatt gcaactaact
     4321 ttactgataa aaaagtagta gttatcacgg ataatgatgg tgattacgaa agtaaagtac
     4381 agtcaaaata tagttcttat caacaattcc agaatataaa agtttcttct gatttagata
     4441 atgataatcg aacatttgag atatgcattt ataattgtaa ctcggattta ttagagtctt
     4501 caggattaac caaatctaat gatttattag aatacatgct cagggaaaag gctgaatttg
     4561 cactgagatt actagaacaa atggaaactg ataatataag ggaaaaattt attataccca
     4621 attatattaa agaggcgatt gaatggataa taaaagattg attcatgctg ttgctggaag
     4681 tggcaaaaca actaaaataa ttgaaaccat cgatcctcaa aaaagaaatc ttatccttac
     4741 gtatacagag acgaaccaga atacaatcag agcaaagttg attgaaaaat ttggctacat
     4801 tcctgagtct acttttattt ttggtgtttt tgagtctctt tatagttttt gcttagtgcc
     4861 atatttaggg aaacgaccaa aaggaataaa ttttgattat aaaactcaag gaaaatttga
     4921 taagactgct atagataata ctggaagaat tgttcagaat caactttcta aatctctatt
     4981 aaggggttca ttaatctata agaggaaaga aattagattt gataattcat atttggatag
     5041 aattgataaa ttttttgatt gtatttatgt agatgagtgt caggattttg agtcagatga
     5101 ttttgattgg ctttt
//
LOCUS       DAVLHC010000087         4897 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.088, whole genome shotgun sequence.
ACCESSION   DAVLHC010000087 DAVLHC010000000
VERSION     DAVLHC010000087.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4897)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4897)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4897
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.088"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            1..495
                     /locus_tag="VXE25_002039"
                     /pseudo
     CDS             1..495
                     /locus_tag="VXE25_002039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611577.1"
                     /note="frameshifted; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=2
                     /transl_table=11
                     /product="transposase"
     gene            492..710
                     /locus_tag="VXE25_002040"
     CDS             492..710
                     /locus_tag="VXE25_002040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000028153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772431.1"
                     /translation="MSISPRFETLEQAIASKDLEKVREAFKKMNSTWTINESVVRDNS
                     IAHYGRVETAISFLPSSMEIEPTDESGT"
     gene            complement(767..1051)
                     /locus_tag="VXE25_002041"
     CDS             complement(767..1051)
                     /locus_tag="VXE25_002041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type B 50S ribosomal protein L31"
                     /protein_id="HEV0772432.1"
                     /translation="MARKETMAERKYCKMKKDIHPEYRPVVFMDTTTGYQFLSGSTKR
                     SNETVEFEGETYPLIRVEISSDSHPFYTGRQKFTQADGRVDRFNKKYGLK"
     gene            complement(1105..2040)
                     /locus_tag="VXE25_002042"
     CDS             complement(1105..2040)
                     /locus_tag="VXE25_002042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional oligoribonuclease/PAP phosphatase
                     NrnA"
                     /protein_id="HEV0772433.1"
                     /translation="MEICQQILEKIKEYDTIIIHRHMKPDPDALGSQVGLKALLEHHF
                     PEKTIKAVGFDEPTLTWMAEMDLVEDRAYQGALVIVCDTANTARIDDKRYSQGDFLIK
                     IDHHPNDDVYGDLSWVDTSSSSASEMITLFAQTTQLALADRDAELLFAGIVGDTGRFL
                     YPSTTARTLRLAAYLREHNFDFAALTRKMDTMSYKIAKLQGYIYDHLEVDENGAARVI
                     LSQKILKQYNITDAETAAIVGAPGRIDRVSLWGIFVEQADGHYRVRLRSKVHPINEIA
                     KEHDGGGHPLASGANSYSLEENEIIYQKLKNLLKN"
     gene            2144..2587
                     /locus_tag="VXE25_002043"
     CDS             2144..2587
                     /locus_tag="VXE25_002043"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin"
                     /protein_id="HEV0772434.1"
                     /translation="MALAKIVFASMTGNTEEIADIVADKLRDLGLDVDVDECTTVDAS
                     DFLEADIAIVATYTYGDGELPDEMMDFYEDLADLNLNGKIYGVVGSGDTFYDEFCKAV
                     DDFDRVFVSTGAEKGSECVKVDLSAEEEDIERLEQFAEELAAKVG"
     gene            2703..2969
                     /locus_tag="VXE25_002044"
     CDS             2703..2969
                     /locus_tag="VXE25_002044"
                     /EC_number="5.4.99.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chorismate mutase"
                     /protein_id="HEV0772435.1"
                     /translation="MDLDIIRQEIDQIDDQIVKLLEERMHLVEGVVAYKKASGKPILD
                     TKREAVIFEKVRSRVEDKRYQETIVATFSDILKRSRDYQDQNIK"
     gene            2966..3340
                     /gene="crcB"
                     /locus_tag="VXE25_002045"
     CDS             2966..3340
                     /gene="crcB"
                     /locus_tag="VXE25_002045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000712114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fluoride efflux transporter CrcB"
                     /protein_id="HEV0772436.1"
                     /translation="MKKEQFYPLGIFLAAMLGGLVRYLVSTWLPASPDFPWGTLFVNY
                     LGIFCLIYLVKGYLVYKGTSKGLILALGTGFCGGLTTFSSLMLDTVKLLDTGRYLSLI
                     LYLLLSIGGGLLLAYYLGRKKW"
     gene            3334..3663
                     /gene="crcB"
                     /locus_tag="VXE25_002046"
     CDS             3334..3663
                     /gene="crcB"
                     /locus_tag="VXE25_002046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000237393.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fluoride efflux transporter CrcB"
                     /protein_id="HEV0772437.1"
                     /translation="MVIVYLAIACGLGALVRYFFSRYNQASKLPLGTLIANLLGCFLI
                     GVFYNHVESKEVYAILATGFCGGLTTFSTLNDELQRLLSDKKVFYSYLTLTYIGGLVA
                     IFLGILL"
     gene            3782..4129
                     /gene="rplS"
                     /locus_tag="VXE25_002047"
     CDS             3782..4129
                     /gene="rplS"
                     /locus_tag="VXE25_002047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005590628.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L19"
                     /protein_id="HEV0772438.1"
                     /translation="MNPLIQSLTEGQLRTDIPSFRPGDTVRVHAKVVEGNRERIQIFE
                     GVVIARKGAGISENYTVRKISNGVGVERIFPIHTPRVEKIEVVRYGKVRRAKLYYLRA
                     LQGKAARIKEIRR"
     gene            4171..4242
                     /locus_tag="VXE25_002048"
     tRNA            4171..4242
                     /locus_tag="VXE25_002048"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:4204..4206,aa:Arg,seq:cct)
     gene            complement(4409..>4897)
                     /locus_tag="VXE25_002049"
     CDS             complement(4409..>4897)
                     /locus_tag="VXE25_002049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001008999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HEV0772439.1"
                     /translation="KATFGDIKWSLLNKQAHRNTVSGDFGCLSNTRKAQGRHLEQEGN
                     IKHALIYYIESLIITISGLKNNFSATDYPVYYPDSIPDYSLKHIQTLMESLSDDDYDF
                     AFDEALFRFSILNANHFLSKEDIDYLRVNLPRSTAEEINNYLKKYECYSPLNNLELDD
                     FE"
BASE COUNT         1444 a          860 c         1045 g         1548 t
ORIGIN      
        1 aaaaaaatat gaggagttcg gactcgactc tctccttcaa gaaacacgtg gtggtcgtaa
       61 ccatgcatat atgacagttg aggaagagaa agcctttctt gcccgtcatt tgaaggctac
      121 agaggcagga gaatttgtta caattgatgc cttatttcag gtttataaaa aggagtgtgg
      181 atgaacgcct ttttagaaga gctttcacaa gcttatcctt ttactcgtta tggacaatgc
      241 tatatggcat aaatcaagta ccttaaatat tccgactaat attgatttta cctttattcc
      301 tccatacaca ccagagatga acccattgaa caagtgtgga aagagattcg taaacgtgga
      361 tttaagaata aagcctttcg aactttggaa gatgtcatga atcaacttca agatgtcata
      421 caaggactgg agaaggaggt gataaagtcc atcggtaatc ggagatggac tagaatgctt
      481 tttgaaagca gatgagtata agtcctcgtt ttgaaacctt agagcaggcc attgcctcca
      541 aagatttgga aaaagtccga gaagctttta agaaaatgaa ttccacttgg accatcaatg
      601 aaagtgtggt tcgtgacaat agtatagctc attatggacg tgttgaaaca gctatttcct
      661 tcctgcctag tagcatggaa atcgaaccta cagatgagtc tggaacatga aaacagcagt
      721 tgatttcaag aaacaaaaaa gaacagccaa aactgttctc ttatcattat ttgagaccgt
      781 attttttgtt gaaacgatcc acgcgtccat ctgcttgagt gaacttttga cgtccagtgt
      841 agaatgggtg tgagtctgat gaaatttcca cacggatcaa tgggtaagtt tcgccttcga
      901 actcaactgt ttcgttagag cgttttgttg aaccgctaag gaattggtaa ccagtagttg
      961 tgtccatgaa gacaactggg cgatattctg gatggatatc ttttttcatt ttgcaatatt
     1021 tcctttctgc catggtctct ttgcgagcca tagattgtta ctatactagt ctatcagatt
     1081 ctgaaaagtt tggcaagtat tttatcagtt tttaagcaag ttttttaact tttggtagat
     1141 gatttcgttt tcttctaggc tataggaatt agcaccactt gctagagggt ggcctccacc
     1201 atcatgctcc ttggcaattt cattgatagg atggacttta ctgcgtaagc gaactcggta
     1261 gtggccatca gcctgttcga caaaaattcc ccagagactc actctgtcaa tgcgtccagg
     1321 tgcacctaca atggccgcag tttcagcatc ggttatattg tattgtttca agattttctg
     1381 actcaggata acgcgagcag caccattttc atccacttcc agatggtcgt agatgtagcc
     1441 ttgcagttta gcaattttgt agctcatagt gtccattttg cgagtgagag ccgcaaagtc
     1501 aaagttatgt tctctcaaat aagcagccag gcgaagagtc cgtgcagtgg tagaagggta
     1561 gaggaagcga cctgtatcac cgacaattcc tgcaaagagc aactcagcat cgcgatctgc
     1621 caaggctagt tgggttgttt gggcaaatag ggtaatcatc tcgctagcgc tacttgaact
     1681 agtatcgacc caagacaggt caccgtatac atcatcattt ggatggtggt caatcttaat
     1741 gagaaaatca ccttgactat agcgcttatc atcgatacga gcagtattag ctgtatcaca
     1801 gacgatgaca agtgcgcctt ggtaggctct atcttcaaca agatccatct cagccatcca
     1861 agtaagagtt ggttcatcaa aaccgacggc tttgatggtt ttttctggga aatgatgttc
     1921 tagcaaggct ttcaatccca cctgacttcc caaggcatca gggtctggtt tcatatgacg
     1981 atgaatgata atggtgtcgt attctttaat tttttctaaa atttgttggc aaatctccat
     2041 aaataacctc aattctttct catttcattg tagcacaaga atttttattt ttaaaatgaa
     2101 aaagatgtga tataatggag aaagataaat tgaggaggac gatatggcat tagcaaaaat
     2161 tgtatttgcc agtatgaccg gtaataccga agaaattgca gatattgtag cagacaaatt
     2221 acgtgacttg ggcttggatg ttgatgttga tgaatgtaca actgttgacg cttcagactt
     2281 cttggaagca gacatcgcta tcgttgcgac ctatacttat ggtgatggtg aattgccaga
     2341 tgagatgatg gacttctacg aagacctagc agatctcaac ttgaatggca aaatctacgg
     2401 agtggtcggc tcaggagata ccttctacga tgaattttgt aaggctgttg atgactttga
     2461 ccgtgtcttt gtgtcaacag gagcagaaaa aggttcagag tgtgttaaag ttgatctttc
     2521 tgccgaggaa gaagatattg aacgcttgga acaattcgca gaagaattgg ctgctaaagt
     2581 aggataagca taaaagtgcg ctgatgtaat caatcagtgc atttttctta tcgagagttg
     2641 ggattttact agcctaattg atggcttttt gatacaataa ttcaaataaa ggaggagact
     2701 gtatggattt agatattatt cgtcaagaaa tcgatcaaat cgacgaccaa attgtcaaac
     2761 tgttagaaga acgaatgcac ttagttgaag gagttgtcgc ttataagaag gcttcaggga
     2821 aaccgatttt agatactaag agagaagcag ttatttttga aaaggttaga agtcgtgtag
     2881 aggacaagcg ctatcaggag actattgtcg cgactttttc ggacatactc aaacgttcgc
     2941 gtgattatca ggatcaaaat atcaaatgaa aaaagaacaa ttttatccgc tagggatttt
     3001 tctagctgct atgttgggcg gacttgtccg ctacctagtt tccacttggt taccagccag
     3061 tccagatttc ccttggggca ctctctttgt caactatctg ggaattttct gcttgattta
     3121 tcttgtcaag ggctatctgg tctataaggg gactagtaag ggcttgattt tagcactggg
     3181 gacgggtttt tgcggaggtt taacaacttt ttccagccta atgcttgata ctgtgaagct
     3241 gcttgataca gggcgttatc ttagtttgat actgtatttg cttttgagta tcggtggagg
     3301 cctgctttta gcttactatt tggggaggaa gaaatggtaa tcgtctatct tgcaatcgcc
     3361 tgtggcttgg gagcactcgt acggtatttc ttttctcgct ataatcaagc ttctaaattg
     3421 ccactcggaa cgctcatagc taatctttta ggttgttttt taattggagt attctacaat
     3481 catgtagagt ctaaggaagt atatgctatt ctagcaacag gattttgtgg cggtttaaca
     3541 actttttcga ccttgaatga cgaacttcaa agactgctaa gtgataagaa ggtcttttat
     3601 tcttacctga ctttgactta cataggtggt ttggttgcga tttttttagg aattttgcta
     3661 taaatttctt tacttttttg tgaaaatttg gtaaactgta tcttgtgtgt aatggacgca
     3721 caagaataca gtttatccgc tgaggaagtt tcctcaagat tgacaaagat aggagaataa
     3781 aatgaatcca ttaatccaaa gcttgactga aggtcaactt cgtacagata tcccatcatt
     3841 ccgtcctggt gacactgttc gtgtacacgc gaaagttgtc gaaggtaacc gtgaacgtat
     3901 ccagattttt gaaggtgttg ttatcgcacg taaaggtgct ggaatctcag aaaactacac
     3961 agttcgtaaa atctctaacg gtgtaggtgt tgagcgtatc ttcccaatcc acactccacg
     4021 tgttgaaaaa atcgaagttg ttcgttacgg taaagtacgt cgtgcgaaat tgtactactt
     4081 gcgtgctctt caaggtaagg cagctcgtat caaagaaatc cgtcgttaat tcgactaaaa
     4141 aactctgctt ttcagcagag tttttatcta gctcccttag ttcaatggat ataacaactc
     4201 cctcctaagg agtagttgca ggttcgattc ctgcaggggg catgtaatta gatatcaaag
     4261 aagtttgtca aaaagtcttt gatattaaaa gaacgcataa tataggggat tgtctccata
     4321 atattatgcg ttttattatt gaaaaatttg ggcaatcatc agataaaatt gagactatat
     4381 cgagtatata aatgtttgta tagtcaattt attcaaaatc gtcaagttct aaattattta
     4441 aaggactata acattcatat ttctttaagt aattgtttat ttcttcagca gtggaacgag
     4501 gtaaattaac tcttaaatag tcaatatctt ccttagataa aaaatgattt gcattcaaaa
     4561 ttgagaagcg aaataatgct tcatcaaaag caaaatcata atcgtcatca gataatgatt
     4621 ccattaatgt ttgaatatgt tttagtgagt agtcaggtat cgaatcggga taatatactg
     4681 gataatcagt ggctgaaaaa ttgtttttta atcctgaaat agtaattatc aaagattcta
     4741 tgtaatatat taaagcatgt ttaatattac cttcttgttc caaatgtctt ccctgagcct
     4801 ttcgtgtgtt agataagcat ccaaaatctc ctgatacagt attcctatga gcttgtttat
     4861 ttaagagact ccattttata tcaccaaaag ttgcttt
//
LOCUS       DAVLHC010000088         4828 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.089, whole genome shotgun sequence.
ACCESSION   DAVLHC010000088 DAVLHC010000000
VERSION     DAVLHC010000088.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4828)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4828)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4828
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.089"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(<1..2501)
                     /locus_tag="VXE25_002050"
     CDS             complement(<1..2501)
                     /locus_tag="VXE25_002050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000339678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase S74"
                     /protein_id="HEV0772440.1"
                     /translation="MDALTRRQFDRSMFAKERTLAIRVGEYASRDIKEASFEYGYIKG
                     DTYKPGGTCAGSGKITFTSIITTFNKLDTLHPEIGLLVGDTYQWVKMGEYFINDIEID
                     RNRNTTTLELMDGMFKLNREYVTDLHFPAEVREVIQEICLKTGIELANDYFGISAMRY
                     HIEQVPEGKKLSFRDMLSAMTQMIGMSCFFNREGKMEIRDLTESNITINADSYFLHGL
                     TKSEIEYQIAGITCKTDKKSLTVGMKTGRSLELDNVFMTQSALNDLYYKLKNLTYYPY
                     NLNYQGHLLLEVGQWVTIQTNKKETFKVPVLSQSFTFKGGLRGRISADSKAGNDTQYS
                     YEGTITKHIKQQGGIEAKIQAQIEATDKDFDQKVDKIKKDFNDQVELAKAKAEEVKRE
                     LSDTINQRFNSFDNGPLKETKRKAEEALRNAGASTLLAQEAKRIGLDSVARLEAFKSQ
                     TTSAQTALSGDLDALKRTIANDIRPKQAQAEAEIAKQVEALSRTKNELAGASSLLAQE
                     AKRIELDSVARLEAFKSQTTSAQTALSGDLDVLKRTIANDIRPKQAQAEAEIAKQVEA
                     LSRTKNELAGVKSAQATYEETTTRRLSELTNLANGKASKSELTQTAEELASRIASVQV
                     GGRNYIRGTKRMMLARGLWASGTFRPSGAGTAKTIDVSDSPATGFDKAIRLTSSNARD
                     QIGIAQDGFYISQGTYTMSCWVKGRRGQKVKLQTYWQVNDNSGISPIFTLKDENWTKL
                     SFTSARNRAGVASIGYVYLVNAEVGEYLDVLAPQLEDGSLATSSKEAPEDIEGQISTV
                     ESTFKQRANSLEAGVSRLTEGLRTKADISSLNVTA"
     gene            complement(2506..2856)
                     /locus_tag="VXE25_002051"
     CDS             complement(2506..2856)
                     /locus_tag="VXE25_002051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399159.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772441.1"
                     /translation="MAQLTINGVAVKPPKSFQVGIQDIDGETGRNANGDMVRDRITTK
                     RKLDCEWGMMTQGEISQLLHAVSSEFFEVSYPDPMDGQVTKTFYVGARTAPSYTFTEK
                     FKPWSGAKFNLVER"
     gene            complement(2865..>4828)
                     /locus_tag="VXE25_002052"
     CDS             complement(2865..>4828)
                     /locus_tag="VXE25_002052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000212166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772442.1"
                     /translation="FYDVITSTGAVRIGSAIVSTLLSLTSTIVEVGSKLAGSLFKGFE
                     KVVVTSAPKISSVFQSLLDTVAPVFESIERSVNKFGDGLSRVYDEHVVPAINSIANAF
                     NGLIDIIQILWENSWQPFAEFLSGVFGVSIEGISDLLGGGLLATLGLLAYAIKLVADG
                     FTVFSDWCKENKEPIVALITTWQTINFLSWAEQAGGLAGAFSLLGSKVSLIVGGIKNL
                     GLAIKALTFDKLVSFAETIYLNTLYAKDFVVNSGKTIAQLGKTALELGKSALAWTAHA
                     AKMGLATAAEFAHSVAAGVATAATWAFNAALAVLTSPITWIIAAIAALIAIGVLLYQN
                     WDTVVEFAKTAWQGLCDFISGICQAIGEFFSGLWTKLQEIFEPIGQWFGEKFQQAWDA
                     IGNIFGNLGSWFGGRWNDSKNALAEANTWLGDKFKSGRDKVNSAFEKVGSWFGDRWND
                     IKDGVKEADTWFGEKFESAKKKTQNPFQKIGSWFGDRWKDMQDALKEIPNWFKNLFND
                     AMDNAKNIVKSGIDKLKSFFNFDWSLPKIKLPHFNISGSFSLMPPRIPSFSVDWYARG
                     GVFNSPSIIGVGEAGQEAVMPLERNTGWISILAQKLAERMPANNVPTGYSLPAGDIVI
                     QIAGHEFGRVAIQEINKEHERAGQTLLKI"
BASE COUNT         1289 a         1201 c          906 g         1432 t
ORIGIN      
        1 tcagcagtca cattgagtga gctgatatcc gctttagttc taagcccttc agtcagacgg
       61 cttacaccag cttcgagcga gttggcacgc tgtttgaagg tcgattcaac tgttgaaatc
      121 tgaccttcta tatcttcagg agcttctttt gagcttgttg ccaaacttcc gtcttccagc
      181 tggggcgcaa gaacatctaa atattctccg acctcagcat ttacgagata cacatagcca
      241 attgatgcga ctccagccct atttctagcg ctagtaaacg atagctttgt ccaattttca
      301 tcctttaatg taaagatggg cgaaataccc gaattatcat tgacttgcca ataagtttgt
      361 agcttgacct tttgacctct tctgcctttg acccaacaag acatcgtgta tgtgccttgc
      421 gagatataaa atccatcttg agcaatacct atttggtctc tagcattgct tgaggtcaat
      481 cgtatcgctt tatcaaagcc agttgctgga ctgtctgata catcaatcgt ctttgccgtc
      541 ccagcgcctg acggtctaaa agtacctgat gcccacaatc ctctggctag catcatgcgc
      601 tttgtacccc ggatataatt cctacccccg acctgcacac tcgctatccg actagccagc
      661 tcctcagctg tttgcgtgag ttctgacttg ctggctttac cattggccaa gttggtcagt
      721 tctgaaagtc tacgagtcgt cgtctcctca tacgtcgctt gcgctgactt cacgccagcc
      781 agttcatttt tagtccggct aagtgcttca acttgcttgg caatctcagc ttcagcctgt
      841 gcttgcttcg gtcgaatatc gtttgcgata gttcgtttta gaacatccaa gtcacctgac
      901 aaagccgtct gagcgctcgt agtctgcgac ttaaacgctt caagtctagc gacagaatcc
      961 agctcaatcc gcttagcttc ctgagcgagt aagctacttg cgccagccag ttcattttta
     1021 gtccggctaa gtgcttcaac ttgcttggca atctcagctt cagcctgtgc ttgcttcggt
     1081 cgaatatcat tcgcgatagt ccgtttcaga gcgtccaagt cacccgacag agccgtttgt
     1141 gcgctcgtag tctgcgactt aaacgcttca agtctagcga cagaatccag tccaatccgc
     1201 ttagcttcct gtgcaagcag ggtacttgcg ccagcatttc gcaaagcttc ctcagccttg
     1261 cgcttagttt ctttcaatgg cccgttgtca aagctattaa atcgctgatt gatagtgtca
     1321 gacagttctc tcttgacttc ttccgccttg gccttggcaa gttctacttg atcgttaaag
     1381 tcttttttga ttttgtcgac cttttggtca aaatctttat ctgttgcttc aatctgcgct
     1441 tggattttcg cttcaatgcc accttgttgc ttaatatgct tggtaatcgt accctcgtaa
     1501 gaatactgag tatcgtttcc agccttacta tctgcgctga tacgccctct cagaccacct
     1561 ttaaaagtaa agctctgact taacacagga actttaaagg tctctttctt attggtctga
     1621 atggttaccc actgcccgac ctcaagcagt aaatgccctt ggtagttgag attatacgga
     1681 tagtaagtta ggtttttcag tttgtaatac aggtcattta aagcgctctg ggtcatgaag
     1741 acattgtcca gttccaaaga ccggcccgtc ttcataccga ccgtcagaga cttcttgtcc
     1801 gtcttacaag tgataccagc tatctgatac tcaatctcac tcttggtcaa gccatgcaag
     1861 aagtaactgt cagcgttgat cgtgatattg gactcagtca aatcacggat ttccatcttg
     1921 ccttctctgt tgaagaaaca agacatccca atcatctgag tcatagcgct cagcatatcc
     1981 ctaaaggaaa gtttcttgcc ctcaggaact tgctcaatat gataacgcat cgcgctgatt
     2041 ccgaaatagt cattcgctaa ctcaatgcct gttttcaggc agatttcctg aataacctct
     2101 cgtacttcag ctgggaaatg caagtccgtc acgtactcac gattgagctt aaacataccg
     2161 tccataagtt caagcgtggt agtgtttcgg tttcggtcaa tctcaatatc gttgatgaag
     2221 tattccccca tcttgaccca ctggtaggta tccccaacca gtagaccaat ctcagggtgc
     2281 agggtatcca gcttattgaa cgtggtaatg atactggtaa aggtaatttt accgctacca
     2341 gcgcaggttc caccaggctt ataagtatcg cccttgatgt agccatactc aaaactagcc
     2401 tctttgatat cccgtgaagc atattcacca acacgaatag ccagcgtcct ttccttggca
     2461 aacatagatc tgtcaaattg tcgtctagtt aaagcgtcca ttttcttacc tctctaccag
     2521 attaaattta gcgccagacc aaggtttaaa cttctcagta aaggtatagc taggagctgt
     2581 cctagcaccg acatagaaag tctttgtgac ttggccatcc atggggtctg gataagatac
     2641 ctcaaaaaat tcagatgata cagcatgtaa aagctgactt atttctccct gagtcatcat
     2701 accccattca cagtctagtt tgcgtttggt cgtgatacgg tcacgcacca tgtcgccatt
     2761 ggcattacgc cctgtctctc catcgatatc ttgaataccg acttgaaaag atttgggagg
     2821 cttcacagcc accccattga ttgtcaattg tgccatttaa cctcctaaat cttgagcaag
     2881 gtttgacctg ctcgttcatg ttccttgttg atttcttgga tagctacccg tccgaactca
     2941 tggcctgcga tttggataac gatgtcgcca gccggtaatg aataacctgt aggtacatta
     3001 ttagcaggca ttctttcagc cagtttttga gccaagatag aaatccatcc tgtattccgt
     3061 tcaagaggca ttaccgcttc ttgaccagct tctccgaccc caatgatgct aggagagttg
     3121 aatacaccgc ctcgtgcata ccaatctaca gagaatgatg gaattctagg aggcatcaag
     3181 ctgaagctac cagatatatt aaagtgaggg agtttgattt ttggtaagct ccaatcaaag
     3241 ttaaagaagc tttttagttt atcgatacca cttttaacga tgtttttagc attatccatt
     3301 gcatcattaa acagattctt gaaccagttg gggatttctt tcaaggcatc ttgcatatct
     3361 ttccatctat caccaaacca agaaccgatt ttttggaaag gattctgagt tttctttttt
     3421 gcactctcaa atttctctcc aaaccatgta tcagcttctt tcactccatc tttgatatca
     3481 ttccaacggt caccgaacca agagccaact ttttcaaaag ctgagttcac tttatcccga
     3541 cctgacttga acttatcacc aagccaagta tttgcttcgg caagtgcgtt tttagaatca
     3601 ttccaacggc caccaaacca agagcctaag ttgccaaata tatttccaat agcgtcccat
     3661 gcttgctgga atttctcgcc aaaccattga cctatcggct caaagatttc ttgtagtttc
     3721 gtccatagac cgctgaaaaa ttcgccaatc gcttgacaaa taccactgat aaaatcacat
     3781 agtccttgcc atgcagtttt agcaaactca acaacagtgt cccaattttg gtagagcaaa
     3841 acaccgatag caattaaggc tgcgattgct gcaataatcc atgttattgg acttgtcaaa
     3901 actgctaacg ctgcattaaa agcccatgtt gcagctgtag cgactcctgc tgcaacagaa
     3961 tgtgcaaatt ccgccgcggt tgctaatccc attttcgctg catgagcagt ccatgctaga
     4021 gctgatttac caagttctaa agcagttttt cctagctgtg caattgtttt acctgaattg
     4081 accacaaaat cttttgcata taaggtgttc aaatagattg tttcagcaaa actgaccaac
     4141 ttatcaaatg tcaatgcttt aatagcaaga cctagattct taattcctcc aacaatcaaa
     4201 gagaccttac tacctaacaa gctgaatgct cctgcaagtc ctccagcttg ttctgcccat
     4261 gataagaaat taatcgtttg ccaagttgtt atcaaagcta cgataggttc tttgttttct
     4321 ttacaccagt cagaaaaaac ggtgaaacca tctgccacta acttaatagc atacgccaat
     4381 agtcccaaag tggctaaaag gccacctcct aataaatctg aaattccttc aatactaaca
     4441 ccgaatactc ctgataaaaa ctcagcaaaa ggttgccagg aattctccca gagaatctga
     4501 ataatgtcaa ttagcccatt aaaagcatta gcaatagagt taatagcagg gactacatgt
     4561 tcatcataaa cacgacttaa gccatcgcca aatttgttaa cagacctttc aatgctctca
     4621 aatacaggcg caacagtatc taataaactt tggaagactg atgaaatttt aggagcgctt
     4681 gtcacaacga ctttttcaaa acctttaaac aaacttcctg ctaatttact accaacttca
     4741 acaatggtag atgtcaaact caacagagtt gacacaatag cgctaccgat acgaaccgca
     4801 ccagttgagg taatgacgtc gtagaaag
//
LOCUS       DAVLHC010000089         4614 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.090, whole genome shotgun sequence.
ACCESSION   DAVLHC010000089 DAVLHC010000000
VERSION     DAVLHC010000089.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4614)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4614)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4614
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.090"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(56..1066)
                     /locus_tag="VXE25_002053"
     CDS             complement(56..1066)
                     /locus_tag="VXE25_002053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YeiH family putative sulfate export transporter"
                     /protein_id="HEV0772443.1"
                     /translation="MSFLSKNGAGILACLLISIVSWYLGGFFPVIGAPVFAIFIGMLL
                     HPFLSSYKQLDAGLTFSSKKLLQYAVVLLGFGLNISQVFAVGQSSLPVILSTISIALI
                     IAYLFQRFFALDTKLATLVGVGSSICGGSAIAATAPVIDAKEKEVAQAISVIFFFNVL
                     AALIFPTLGTWLHLSNEGFALFAGTAVNDTSSVTAAASAWDSLYQSNTLESATIVKLT
                     RTLAIIPITLFLSYWQSRQQENKQSLQLKKVFPLFILYFILASLLTTLLTSLGVSSSF
                     FTPLKQLSKFLIVMAMSAIGLKTNLVAMVKSSGKSILLGAICWIAIILTTLGMQTLIG
                     IF"
     gene            1215..2384
                     /locus_tag="VXE25_002054"
     CDS             1215..2384
                     /locus_tag="VXE25_002054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HEV0772444.1"
                     /translation="MDLTKRFNKQLDKIQVSLIRQFDQAISEIPGVLRLTLGEPDFTT
                     PDHVKEAAKRAIDQNQSYYTGMSGLLTLRQAASDFVKEKYQLDYAPENEILVTIGATE
                     ALSATLTAILEEGDKVLLPAPAYPGYEPIVNLVGAEIVEIDTTENGFVLTPEMLEKAI
                     LEQGDKLKAVILNYPANPTGITYSREQLEALAAVLRKYEIFVVCDEVYSELTYTGEAH
                     VSLGTMLRDQAIIINGLSKSHAMTGWRLGLIFAPATFTAQLIKSHQYLVTAANTMAQH
                     AAVEALTAGKNDAEPMKKEYIQRRDYIIEKMTALGFEIIKPDGAFYIFAKIPAGYNQD
                     SFAFLKDFAQKKAVAFIPGAAFGRYGEGYVRLSYAASMETIKEAMKRLEEYMREA"
     gene            2381..3151
                     /gene="recO"
                     /locus_tag="VXE25_002055"
     CDS             2381..3151
                     /gene="recO"
                     /locus_tag="VXE25_002055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000616164.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RecO"
                     /protein_id="HEV0772445.1"
                     /translation="MIQSITSQGLVLYNRNFREDDKLVKIFTEQVGKRMFFVKHAGQS
                     KLAPVIQPLVLARFLLRINDDGLSYIEDYHEVMTFPKINSDLFVMAYATYVAALADAS
                     LQDNQQDAPLFAFLQKTLELMEAGLDYQVLTNIFEIQNLTRFGISLNFNECVFCHRVG
                     QAFDFSFKYGACLCPEHYHEDKRRCHLNPNIPYLLNQFQAIDFETLETISLKPGIKQE
                     LRQFMDQLYEEYVGIHLKSKKFIDSLADWGQLLKEEKK"
     gene            3148..4140
                     /gene="plsX"
                     /locus_tag="VXE25_002056"
     CDS             3148..4140
                     /gene="plsX"
                     /locus_tag="VXE25_002056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000717456.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate acyltransferase PlsX"
                     /protein_id="HEV0772446.1"
                     /translation="MKKIAVDAMGGDYAPQAIVEGVNQALSDFSDIEVQLYGDEAKIK
                     QYLTATERVSIIHTDEKIDSDDEPMRAIRNKKNASMVLAAKAVKDGEADAVLSAGNTG
                     ALLAAGFFIVGRIKNIDRPGLMSTLPTIDGKGFDMLDLGANAENTAQHLHQYAVLGSF
                     YAKNVRGIAQPRVGLLNNGTESSKGDPLRKETYELLAADESLNFIGNVEARDLMNGVA
                     DVVVADGFTGNAVLKSIEGTAMGIMGLLKTAITGGGLRAKLGALLLKDSLSGLKKQLN
                     YSDVGGAVLFGVKAPVVKTHGSSDAKAVYSTIRQIRTMLETDVVAQTAREFSGE"
     gene            4146..4379
                     /locus_tag="VXE25_002057"
     CDS             4146..4379
                     /locus_tag="VXE25_002057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl carrier protein"
                     /protein_id="HEV0772447.1"
                     /translation="MTEKEIFDRIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEF
                     ILTLEDEFSIEISDEEIDQLQNVGDVVKIIQGK"
     gene            4425..4614
                     /locus_tag="VXE25_002058"
                     /pseudo
     CDS             4425..4614
                     /locus_tag="VXE25_002058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
BASE COUNT         1362 a          881 c         1173 g         1198 t
ORIGIN      
        1 aacatatata cggcaaggcg acgttgacgt ggtttgaaga gattttcgaa gagtattaga
       61 aaatgccgat aagggtctgc ataccaagag tggtgaggat gatggcaatc cagcagatgg
      121 ctccaagaag aatggatttt ccactggatt tgaccatagc gaccagattg gttttgagac
      181 cgatagcact catggccatg acaatgagga atttagagag ttgtttgaga ggggtaaaga
      241 aactactaga cacaccgaga gaggtcagaa gggtggttag gagcgatgca aggataaagt
      301 aaaggataaa aagtgggaag acttttttca gttgtaggct ttgcttgttt tcttgttggc
      361 gactttgcca gtaggataga aagagcgtga tagggataat ggccaaagta cgtgtgagtt
      421 taacaatggt tgcagactcg agggtattgc tttggtaaag actgtcccaa gcgctggcgg
      481 cagccgttac agaggaagtg tcgttgaccg cagtccctgc aaagagggcg aagccttcat
      541 tggatagatg aagccaggtg ccgagggttg gaaagatgag cgcagccaag acattgaaga
      601 aaaagataac ggaaatggct tgggctactt ccttttcctt agcatcaata acgggcgctg
      661 tcgctgcaat ggcagaaccc ccacagatag aagaacctac tccaaccaag gtagccagtt
      721 ttgtatccag tgcaaagaaa cgctggaaga ggtaggcaat aatcagagct attgagatag
      781 tggacaggat gacagggagt gaagattggc caactgcgaa gacctgcgag atattgagac
      841 caaaaccaag caagacaacg gcatattgga gcaacttctt ggaactaaag gtcaaaccag
      901 catccagttg tttataggac gagagaaagg gatgtaggag catgcctatg aaaatggcaa
      961 aaacgggcgc gccaatcaca gggaagaatc ctcctaagta ccaagatacg atagaaatga
     1021 gaaggcaggc caagatacct gctccatttt ttgatagaaa tgacataaaa acctccaaat
     1081 aaaatctatt accattatag acctataaac aggaaaagta aaatagaaag tggaaagcta
     1141 ttctctaatg tatttttgcg gtcggggggc ttttgtagta taatagagat acgttttgaa
     1201 agtaggaggt atctatggac ttaactaagc gctttaataa acagttagat aaaattcaag
     1261 tttcgttgat tcgtcagttt gaccaggcta tttcggagat tcctggggtc ttgcgtttga
     1321 ccttggggga acctgatttt acaacgccag accatgtcaa ggaggcggcc aagcgagcga
     1381 ttgatcagaa ccaatcctac tatacaggga tgagtggtct gctgactcta cgtcaggcgg
     1441 ccagtgattt tgttaaggaa aagtaccaac tggactatgc tcctgaaaat gaaatcttgg
     1501 tcactatcgg agcgacagag gctttatctg cgactttgac ggctattttg gaagagggag
     1561 acaaggtact tttgccagct cctgcttatc caggctatga accgattgtt aacttagttg
     1621 gggcagaaat tgttgagatt gatacgactg aaaatggttt tgtcttgact cctgagatgt
     1681 tggagaaggc cattttggag cagggtgata agctcaaggc ggttattctc aactatccag
     1741 ccaatccgac aggaattacc tacagtcgag agcagttaga ggccttggca gctgttttac
     1801 gcaagtacga aatttttgtt gtctgtgatg aggtttactc agaattgacc tacacaggcg
     1861 aagcccatgt gtctctagga acgatgttga gagaccaggc tattattatc aatggtttgt
     1921 ctaaatcgca tgccatgaca ggttggcgtt tggggctgat tttcgctcct gcgaccttca
     1981 cagcccagtt aatcaagagt caccagtact tggtcactgc cgcaaatacc atggcgcaac
     2041 atgctgcggt agaagccttg acggctggta aaaacgatgc ggagcccatg aagaaggaat
     2101 atatccaacg tcgggactat atcatcgaaa aaatgactgc tcttggtttt gagattatca
     2161 aaccagacgg tgccttctat atttttgcta aaattccagc gggctacaat caagactcct
     2221 ttgcttttct gaaggatttt gctcagaaga aggccgttgc ctttatccct ggtgcagcct
     2281 ttggacgtta cggggaaggc tacgtccgcc tatcttatgc agccagcatg gagactatca
     2341 aagaagccat gaaacgactt gaggagtaca tgagagaagc atgattcagt ctatcacgag
     2401 tcaaggcttg gtgctttaca atcgcaattt tcgtgaggat gacaagctcg tcaaaatttt
     2461 tacagagcag gttggcaaac gcatgttttt tgtcaaacac gctggtcagt ctaagctggc
     2521 gcctgttatt cagcccttgg tgctggcacg atttctcttg cgaatcaatg atgacggact
     2581 cagttacatc gaagactatc atgaggtcat gacttttccc aagattaata gtgacctctt
     2641 tgtcatggcc tatgcgacct atgtggcagc tcttgcagat gctagtttgc aggacaatca
     2701 gcaggatgct cccttgtttg cttttttgca aaagactttg gagttgatgg aagcaggctt
     2761 ggattatcag gttttgacca atatttttga aattcaaaat ttgactcgat ttggaatcag
     2821 cctcaatttt aatgagtgtg tcttctgcca tcgggttggt caggcttttg acttttcttt
     2881 caaatatgga gcctgcctct gtccagagca ttatcatgag gataagagac gttgtcatct
     2941 caatcccaat atcccctatc tgctcaatca atttcaagct attgattttg agactttgga
     3001 gaccatttcg ctcaagcctg gaatcaagca agagctacgc caatttatgg atcaattata
     3061 tgaagagtac gttgggattc acctaaaatc aaagaaattt attgattccc tagcagactg
     3121 gggacaatta ctaaaagagg aaaagaaatg aaaaaaatcg cagtagatgc catggggggc
     3181 gattacgcac ctcaggccat tgttgagggt gtcaatcaag ccctatctga cttttcagat
     3241 atcgaggttc aactttacgg agatgaagct aaaatcaagc aatatctgac agcgacagag
     3301 cgcgtcagca ttatccatac ggatgagaag attgattcgg atgatgaacc tatgagagct
     3361 attaggaata agaaaaatgc cagtatggta ttggcagcca aggctgtcaa agatggtgaa
     3421 gcagacgctg tcctttcggc tgggaataca ggtgccttgt tggcagcagg attcttcatc
     3481 gtgggtcgta tcaagaatat cgaccgtcct ggacttatgt caacattgcc gactatagat
     3541 gggaaaggtt ttgacatgct tgacctcggt gctaatgcag aaaatacagc ccagcacctc
     3601 catcaatacg ctgtcctagg ttctttctat gccaagaatg ttcgtggcat tgcgcaacca
     3661 cgtgttggtt tgctcaacaa cggaacagag agtagcaagg gcgacccgct tcgtaaggaa
     3721 acttatgaat tactggcggc tgatgaaagt ttgaacttta tcggaaacgt ggaagcgcgt
     3781 gatttgatga atggcgttgc agatgttgtt gtggcagatg gtttcacggg aaacgctgtg
     3841 ctcaaatcca tcgaagggac agctatggga atcatgggct tgctcaagac agctattaca
     3901 ggtggtggtc ttcgagcgaa actaggtgcc ctccttctca aggacagcct cagtggtttg
     3961 aaaaaacagc tcaattattc agatgttggt ggagcggtct tgtttggtgt taaggcacct
     4021 gttgtcaaga ctcatggctc aagcgatgcc aaggctgttt atagtacgat tcgccagatt
     4081 cgtaccatgc tagaaacaga cgtagttgcc cagactgcgc gtgaattttc aggagaataa
     4141 aagagatgac agaaaaagaa atttttgacc gtattgtgac cattatccaa gagcgacagg
     4201 gagaggactt tgtcgtgaca gaatccttga gtctgaaaga cgatttggat gcggattctg
     4261 ttgacttgat ggagtttatc ttgactctgg aagatgaatt tagtatcgaa atcagcgatg
     4321 aagaaattga ccaactccaa aacgtaggag atgtggttaa aatcattcaa ggaaaatagc
     4381 aatcggagtt ccaagtcaac ggaagtagat ggtttttaga aatgagaaat atcggacaag
     4441 ctggaaaaat cttggctgac agtggttatc aagggctcat gaagatatat cctcaagcac
     4501 aaactccacg taaatccagc aaactcaagc cgctaacagt tgaagataaa gcctgtaatc
     4561 atgcgctatc taaggagaga agcaaggttg agaatatctt tgccaaaata aaaa
//
LOCUS       DAVLHC010000090         4227 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.091, whole genome shotgun sequence.
ACCESSION   DAVLHC010000090 DAVLHC010000000
VERSION     DAVLHC010000090.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4227)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4227)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4227
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.091"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(<1..195)
                     /locus_tag="VXE25_002059"
     CDS             complement(<1..195)
                     /locus_tag="VXE25_002059"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772448.1"
                     /translation="MADRTDEVSSKHRFEVADRTDEVSSKHRFEVADRTDEVSSKHCF
                     EVADRTDEVSSKHCFEVADRT"
     gene            593..820
                     /locus_tag="VXE25_002060"
     CDS             593..820
                     /locus_tag="VXE25_002060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000576349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772449.1"
                     /translation="MIFKAFKTKKQRKRQVELLLTVFFDSFLIDLFLHLFGIVPFKLD
                     KILIVSLIIFPIISTSIYAYEKLFEKVFDKD"
     gene            1108..4005
                     /gene="nanA"
                     /locus_tag="VXE25_002061"
     CDS             1108..4005
                     /gene="nanA"
                     /locus_tag="VXE25_002061"
                     /EC_number="3.2.1.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014632427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG-anchored neuraminidase NanA"
                     /protein_id="HEV0772450.1"
                     /translation="MNRSVQERKCRYSIRKLSVGAVSMIVGAVVFGTSPVLAQEGASE
                     QPLANETQLSGESSTLTDTEKSQPSSETELSGNKQEQERKDKQEEKIPRDYYARDLEN
                     VETVIEKEDVETNASNGQRVDLSSELDKLKKLENATVHMEFKPDASAPRFYNLFSVSS
                     DTKEDEYFTMAVYNNTATLEGRGSDGKQFYNNYNDAPLKVKPGQWNSVTFTVEKPTAE
                     LPKGRVRLYVNGVLSRTSLRSGNFIKDMPDVTHVQIGATKRANNTVWGSNLQIRNLTV
                     YNRALTPEEVQKRSQLFKRSDLEKKLPEGAALTEKTDIFESGRNGNPNKDGIKSYRIP
                     ALLKTDKGTLIAGADERRLHSSDWGDIGMVIRRSEDNGKTWGDRVTITNLRDNPKASD
                     PSIGSPVNIDMVLVQDPETKRIFSIYDMFPEGKGIFGMSSQKEEAYKKIDGKTYQILY
                     REGEKGAYTIRENGTVYTPDGKATDYRVVVDPVKPAYSDKGDLYKGDQLLGNIYFTTN
                     KTSPFRIAKDSYLWMSYSDDDGKTWSAPQDITPMVKADWMKFLGVGPGTGIVLRNGPH
                     KGRILIPVYTTNNVSHLNGSQSSRVIYSDDHGKTWHAGEAVNDNRQVDGQKIHSSTMN
                     NKRAQNTESTVVQLNNGDVKLFMRGLTGDLQVATSKDGGVTWEKDIKRYPQVKDVYVQ
                     MSAIHTMHEGKEYIILSNAGGPKRENGMVHLARVEENGELTWLKHNPIQKGEFAYNSL
                     QELGNGEYGILYEHTEKGQNAYTLSFRKFNWEFLSKDLISPTEAKVKRTREMGKGEMG
                     KGVIGLEFDSEVLVNKAPTLQLANGKTATFLTQYDSKTLLFAVDKEDIGQEIIGIAKG
                     SIESMHNLPVNLAGARVPGGVNGSKAAVHEVPEFTGGVNGTEPAVHEIAEYKGSDSLV
                     TLTTKEDYTYKAPLAQQALPETGNKESDLLASLGLTAFFLGLFTLGKKREQ"
BASE COUNT         1420 a          727 c          924 g         1156 t
ORIGIN      
        1 agttctatct gccacctcaa aacagtgttt tgagctgact tcgtcagttc tatctgccac
       61 ctcaaaacag tgttttgagc tgacttcgtc agttctatct gccacctcaa aacggtgttt
      121 tgagctgact tcgtcagttc tatctgccac ctcaaaacgg tgttttgagc tgacttcgtc
      181 agttctatct gccacctcaa aacggtgttt tgagctgact ttgtcagtct tatctacaac
      241 ctcaaaacag tgttttgagc atcatgcggc tagcttctta gtttgctctt tgattttcat
      301 tgagtataaa aacagatgag tttctgtttt ctttttatgg actataaatg ttcagctgaa
      361 actactttca aggacattat tatataaaag aattttttga aactaaaatc tactatatta
      421 cactatattg aaagcgtttt aaaaataagg tataataaat ttactaacac ttataaaaag
      481 tgatagaatc tatctttatg tatatttaaa gatagattgc tgtaaaaata gtagtagcta
      541 tgcgaaataa cagatagaga gaagggattg aagcttagaa aaggggaata atatgatatt
      601 taaggcattc aagacaaaaa agcagagaaa aagacaagtt gaactacttt tgacagtttt
      661 tttcgacagt tttctgattg atttatttct tcacttattt gggattgtcc cctttaagct
      721 ggataagatt ctgattgtga gcttgattat atttcccatt atttctacaa gtatttatgc
      781 ttatgaaaag ctatttgaaa aagtgttcga taaggattga gcaggaagta tggtgtaaat
      841 agcataggct gatgtccatc atttgcttat aaagagatat tttagtttaa ttgcagcggt
      901 gccctggtag ataaactaga ttggcaggag tctgattgga gaaaggagag gggaaaattg
      961 gcaccaattt gagatagttt gtttagttca tttttgtcat ttaaatgaac tgtagtaaaa
     1021 gaaagttaat aaaagacaaa ctaagtgcat tttctggagt aaatgtctta tttcagaaat
     1081 cgggatatag atatagagag gatcagtatg aatcggagtg ttcaagaacg taagtgtcgt
     1141 tatagcatta ggaaactatc ggtaggagcg gtttctatga ttgtaggagc agtggtattt
     1201 ggaacgtctc ctgttttagc tcaagaaggg gcaagtgagc aacctctggc aaatgaaact
     1261 caactttcgg gggagagctc aaccctaact gatacagaaa agagccagcc ttcttcagag
     1321 actgaacttt ctggcaataa gcaagaacaa gaaaggaaag ataagcaaga agaaaaaatt
     1381 ccaagagatt actatgcacg agatttggaa aatgtcgaaa cagtgataga aaaagaagat
     1441 gttgaaacca atgcttcaaa tggtcagaga gttgatttat caagtgaact agataaacta
     1501 aagaaacttg aaaacgcaac agttcacatg gagtttaagc cagatgcatc agctccacgc
     1561 ttttacaatc tcttctctgt atccagtgac accaaggaag atgagtactt cactatggca
     1621 gtttacaata atactgctac tctagagggg cgtggttcgg atgggaaaca gttttacaat
     1681 aattacaacg atgcaccctt aaaagttaaa ccaggtcagt ggaattctgt gactttcaca
     1741 gttgaaaaac cgacagcaga actacctaaa ggccgagtgc gcctctacgt aaacggggta
     1801 ttatctcgaa caagtctgag atctggcaat ttcattaaag atatgccaga tgtaacgcat
     1861 gtgcaaatcg gagcaaccaa gcgtgccaac aatacggttt gggggtcaaa tctacagatt
     1921 cggaatctca ctgtgtataa tcgtgcttta acaccagaag aggtacaaaa acgtagtcaa
     1981 ctttttaaac gctcagattt agaaaaaaaa ctacctgaag gagcggcttt aacagagaaa
     2041 acggacatat tcgaaagcgg gcgtaacggt aacccaaata aagatggaat caagagttat
     2101 cgtattccag cacttctcaa gacagataaa ggaactttga tcgcaggtgc agatgaacgc
     2161 cgtctccatt cgagtgactg gggtgatatc ggtatggtca tcagacgtag tgaagataat
     2221 ggtaaaactt ggggtgaccg agtaaccatt accaacttac gtgacaatcc aaaagcttct
     2281 gacccatcga tcggttcacc agtgaatatc gatatggtgt tggttcaaga tcctgaaacc
     2341 aaacgaatct tttctatcta tgacatgttc ccagaaggga agggaatctt tggaatgtct
     2401 tcacaaaaag aagaagccta caaaaaaatc gatggaaaaa cctatcaaat cctctatcgt
     2461 gaaggagaaa agggagctta taccattcga gaaaatggta ctgtctatac accagatggt
     2521 aaggcgacag actatcgcgt tgttgtagat cctgttaaac cagcctatag cgacaagggt
     2581 gatctataca agggtgacca attactaggc aatatctact tcacaacaaa caaaacttct
     2641 ccatttagaa ttgccaagga tagctatcta tggatgtcct acagtgatga cgacgggaag
     2701 acatggtcag cgcctcaaga tattactccg atggtcaaag ccgattggat gaaattcttg
     2761 ggtgtaggtc ctggaacagg aattgtactt cggaatgggc ctcacaaggg acggattttg
     2821 ataccggttt atacgactaa taatgtatct cacttaaatg gctcgcaatc ttctcgtgtc
     2881 atctattcag atgatcatgg aaaaacttgg catgctggag aagcggtcaa cgataaccgt
     2941 caggtagacg gtcaaaagat ccactcttct acgatgaaca ataaacgtgc gcaaaataca
     3001 gaatcaacgg tggtacaact aaacaatgga gatgttaaac tctttatgcg tggtttgact
     3061 ggagatcttc aggttgctac aagtaaagac ggaggagtga cttgggagaa ggatatcaaa
     3121 cgttatccac aggttaaaga tgtctatgtt caaatgtctg ctatccatac gatgcacgaa
     3181 ggaaaagaat acatcatcct cagtaatgca ggtggaccga aacgtgaaaa tgggatggtc
     3241 cacttagcac gtgtcgaaga aaatggtgag ttgacttggc tcaaacacaa tccaattcaa
     3301 aaaggagagt ttgcctataa ttcgctccaa gaattaggaa atggggagta tggcatcttg
     3361 tatgaacata ctgaaaaagg acaaaatgcc tataccctat catttagaaa atttaattgg
     3421 gaatttttga gcaaagatct gatttctcct accgaagcga aagtgaagcg aactagagag
     3481 atgggcaaag gagagatggg caaaggagtt attggcttgg agtttgactc agaagtattg
     3541 gtcaacaagg ctccaaccct tcaattggca aatggtaaaa cagcgacttt cctaacccag
     3601 tatgatagca aaaccttgtt gtttgcagta gataaggaag atatcggaca ggaaattatt
     3661 ggtatagcta aaggaagcat cgaaagtatg cataatcttc ctgtaaatct agcaggtgcc
     3721 agagttcctg gcggagtaaa tggtagcaaa gcagcggtgc atgaagttcc agaatttaca
     3781 gggggagtta atggtacaga gccagctgtt catgaaatcg cagagtataa gggatctgat
     3841 tcgcttgtaa ctcttactac aaaagaagat tatacttaca aagctcctct tgctcagcag
     3901 gcacttcctg aaacaggaaa caaggagagt gacctcctag cttcactagg actaacagct
     3961 ttcttccttg gtctgtttac gctagggaaa aagagagaac aataagagaa gaattctaaa
     4021 catttgattt tgtaaaaata gaaggagata gcaggttttc aagcctgcta tctttttttg
     4081 atgacattca agctgatacg aaatcataag aggtctgaaa ctactttcag agtagtctgt
     4141 tctataaaat atagtagatt gaaataagat gtgaacaact ctatcaggaa agtcaaatta
     4201 atttatagaa aaattttagc agtcaag
//
LOCUS       DAVLHC010000091         4116 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.092, whole genome shotgun sequence.
ACCESSION   DAVLHC010000091 DAVLHC010000000
VERSION     DAVLHC010000091.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4116)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4116)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4116
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.092"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            620..1612
                     /locus_tag="VXE25_002062"
     CDS             620..1612
                     /locus_tag="VXE25_002062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEV0772451.1"
                     /translation="MAMIEVEHLQKNFVKTVKEPGLKGALRSFIHPEKQTFEAVKDLT
                     FEVPKGQILGFIGANGAGKSTTIKMLTGILKPTSGFCRINGKIPQDNRQDYVKDIGVV
                     FGQRTQLWWDLALQETYTVLKEIYDVPNSLFHKRMDFLNEVLDLKDFIKDPVRTLSLG
                     QRMRADIAASLLHNPKVLFLDEPTIGLDVSVKDNIRRAITQINQEEETTILLTTHDLS
                     DIEQLCDRIFMIDKGQEIFDGTVSQLKETFGKMKTLSFELLPGQSHLVSHYEGLSDMT
                     IDRQGNSLNIEFDSSRYQSADIIKQTLSDFEIRDLKMVDTDIEDIIRRFYRKEL"
     gene            1614..2432
                     /locus_tag="VXE25_002063"
     CDS             1614..2432
                     /locus_tag="VXE25_002063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000240175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-2 family transporter protein"
                     /protein_id="HEV0772452.1"
                     /translation="MIKLWRRYKPFINAGVQELITYRVNFILYRIGDVMGAFVAFYLW
                     KAVFDSSQESLIQGFSMADITLYIIMSFVTNLLTRSDSSFMIGEEVKDGSIIMRLLRP
                     VHFAASYLFTELGSKWLIFISVGLPFLSVIVLMKIISGQGIVEVLGLTVLYLFSLTLA
                     YLINFFFNICFGFSAFVFKNLWGSNLLKTSIVAFMSGSLIPLAFFPKVVSDILSFLPF
                     SSLIYTPVMIIVGKYDASQILQALLLQFFWLLVMVGLSQLIWKRVQSFITIQGG"
     gene            2434..3219
                     /locus_tag="VXE25_002064"
     CDS             2434..3219
                     /locus_tag="VXE25_002064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003010202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEV0772453.1"
                     /translation="MKKYQRMHLIFIRQYIKQIMEYKVDFVVGVLGVFLAQGLNLLFL
                     NVIFQHIPFLEGWTFQEIAFIYGFSLIPKGMDHLFFDNLWALGQRLVRKGEFDKYLTR
                     PINPLFHILVETFQIDALGELLVGGILLGTTVTSIVWTLPKFLLFLVCIPFATLIYTS
                     LKIATASIAFWTKQSGAMIYIFYMFNDFAKYPISIYNSLLRWLISFIVPFAFTAYYPA
                     SYFLQEKDVFFNVGGLMLISLVFFVISLKLWDKGLDSYESAGS"
     gene            3258..3536
                     /locus_tag="VXE25_002065"
     CDS             3258..3536
                     /locus_tag="VXE25_002065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808742.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family acetyltransferase"
                     /protein_id="HEV0772454.1"
                     /translation="MFVIEEVKDENQKKAVVAEVLKDLPEWFGIPESTQAYIEGTTTL
                     QVWTAYQESDLTRFVSLSYSSEDCAEIDCLGVKKLIKVEKLGANCLLL"
     gene            3521..3718
                     /locus_tag="VXE25_002066"
     CDS             3521..3718
                     /locus_tag="VXE25_002066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0772455.1"
                     /translation="MLATLESEARKKVGYLQVKTVAEGSNKDYDRTNDFYRGLGFKKL
                     EIFPQLWNPQNPCQILIKKLE"
BASE COUNT         1133 a          717 c          896 g         1370 t
ORIGIN      
        1 aaatttatac gagatgatga aagccttaag tgttatttta taaaggttat ttcaagtcgt
       61 tccaaggtaa caagtctaga tcagattgaa gctgataaaa cgatacaaag aaaatattca
      121 agtgagctaa aaaaatttat tggattttat aatgagatta tttgtgagga aaatagtttc
      181 ctacatgtac gaaagaggtg gtcgagttgg tttaggtagt cgatgcgtga gttgataatt
      241 ctcagggtat ggacttcttt ttcatgaatg aggtaaaaga gcaggtattg tttagagaca
      301 atcattctga gcatattttc tggatagagg gagtatccga ttttatgatc aaagttaata
      361 ccgccctctg gtgagaagat gagtaggttg gtaatttaaa ctattaaaca gaatttttga
      421 ttaaaagtat tattttatga gagaaatcct aatttcacaa tccataggca aactcttgca
      481 tttcgttttt tattggacta taataggttg gtataaagcc ttttgtagta ataaaatgta
      541 gaaggtgtag aaagcaagga tttagaatat ttgtagttaa aaacacaatg ttgctattcc
      601 ttacgatagg gagatagata tggcaatgat agaagtggaa catcttcaga aaaattttgt
      661 gaagactgtt aaggaaccgg gcttgaaggg ggctttgcgc tcctttattc atcctgaaaa
      721 gcagaccttt gaagcggtca aggatttgac ctttgaggtt ccaaaagggc agattttagg
      781 atttatcggg gcaaatggtg ctgggaagtc gacaaccatt aaaatgctga caggaatttt
      841 gaaaccaaca tctggttttt gtcggattaa cggcaagatt ccccaggaca atcggcaaga
      901 ttatgtcaaa gatattggcg tagtctttgg acaacgcacc cagctatggt gggatttggc
      961 tctgcaagag acctacactg tcttaaaaga gatttatgat gtgccaaact cgctctttca
     1021 taagcgcatg gactttttga atgaagtctt ggatttgaag gactttatca aggatcccgt
     1081 gcggactctt tcactgggac aacggatgcg ggcggatatt gcggcctcct tgctccacaa
     1141 tcccaaggtt ctttttttag atgagccgac cattggtttg gacgtttcgg ttaaggataa
     1201 tattcgtcgg gcaattactc agatcaatca agaggaagaa actaccattc ttttgaccac
     1261 tcacgatttg agtgatattg agcaactttg tgatcggatt ttcatgattg acaaggggca
     1321 agagattttt gatggaacgg tgagccaact caaggagacc tttggtaaga tgaagactct
     1381 ctcttttgaa ctgctaccag gtcaaagtca tctcgtctct cactatgaag gtctgtctga
     1441 tatgaccatt gatagacaag gaaacagcct caacattgaa tttgatagtt ctcgctacca
     1501 gtcagctgac attatcaagc aaaccctgtc tgattttgaa atccgcgatt tgaagatggt
     1561 ggatacggat attgaggata ttatccgtcg cttctaccga aaggagctct aggatgatca
     1621 aattgtggag acgttataaa ccctttatca atgcaggggt tcaggagttg attacttacc
     1681 gagtcaactt tattctctat cggattggcg atgtcatggg ggcttttgtg gccttttatc
     1741 tctggaaggc tgtctttgat tcttcgcaag agtctttgat tcagggcttc agtatggcgg
     1801 atatcaccct ctacatcatc atgagttttg tgaccaatct tctgactaga tccgattcgt
     1861 cctttatgat tggggaggag gtcaaggatg gctccattat catgcgtttg ttgcgaccag
     1921 tgcattttgc ggcctcctat cttttcaccg agcttggttc caagtggttg atttttatca
     1981 gcgttggcct tccattttta agtgtcattg tcttgatgaa aatcatatcg ggtcaaggta
     2041 ttgtagaggt gctaggatta actgtccttt atctttttag cttaacgctc gcctatctga
     2101 ttaacttttt ctttaatatt tgctttggat tttcagcctt tgtgtttaaa aatctttggg
     2161 gttccaacct acttaagact tccatagtgg cttttatgtc ggggagtttg attcccttgg
     2221 cattctttcc aaaggttgtt tcagatattc tttccttttt gcctttttca tccttgattt
     2281 atactccagt tatgatcatt gttggaaaat acgatgccag tcagattctt caggcactcc
     2341 ttttgcagtt cttctggctc ttagtgatgg tgggattgtc tcagttgatt tggaaacggg
     2401 tccagtcctt tatcaccatt caaggaggtt agtatgaaaa aatatcaacg aatgcatctg
     2461 atttttatca gacaatacat caaacaaatc atggaatata aggtggattt tgtggttggt
     2521 gtcttgggag tctttctggc tcaaggcttg aatctcttgt ttctcaatgt catctttcaa
     2581 catattccat tcctagaagg ttggaccttt caagagatag ctttcattta tggattttcc
     2641 ttgattccca agggaatgga ccatctcttt tttgacaatc tctgggcact agggcaacgc
     2701 ctagtccgaa aaggagagtt tgacaagtat ctgactcgtc ccatcaatcc tctctttcac
     2761 atcctagttg aaacctttca gattgatgcc ttgggtgaac tcttagtcgg tggtatttta
     2821 ttgggaacaa cagtgaccag cattgtttgg actcttccga aattcctgct tttcctagtt
     2881 tgtattcctt ttgcgacctt gatttatact tctcttaaaa tcgcaacagc cagtatcgcc
     2941 ttttggacta agcagtcagg cgccatgatt tacatcttct atatgttcaa tgactttgct
     3001 aagtatccga tttctattta caattctctt cttcgttggt tgattagctt tatcgtgcct
     3061 ttcgccttta cagcctacta tccagctagc tatttcttac aggaaaagga tgtgttcttt
     3121 aacgtaggag gtttgatgtt gatttctctg gttttctttg ttatttccct taaactttgg
     3181 gataagggct tagattccta cgaaagtgcg ggttcgtaaa agctaaagta agactaaaat
     3241 caagaaagaa acttatgatg tttgtaattg aagaagtcaa ggatgaaaat caaaaaaagg
     3301 cagttgtagc tgaggttttg aaggatttgc cagaatggtt tggaatccca gaaagcacac
     3361 aagcctatat agaaggaacc acgacactgc aagtttggac cgcctatcag gagagtgatt
     3421 tgactagatt tgtaagctta tcctattcga gtgaagattg tgcagagatt gattgtctcg
     3481 gcgtaaaaaa gcttatcaag gtagaaaaat tgggagccaa ttgcttgcta ctttagagag
     3541 tgaagctcgt aaaaaagttg gttatctgca ggtcaaaaca gtggcagaag gttctaataa
     3601 agattatgat cgaacaaatg acttttatcg aggtcttggc tttaaaaagt tagagatttt
     3661 tcctcaacta tggaatccgc aaaatccttg tcagattttg attaaaaagc ttgaataata
     3721 ttacttgaca tctattctca gagtgccata ctgtaagtgt aatcgccgat ttagctcagt
     3781 tggtagagca aggcactcgt aaagcctagg ttataggtag ataaacgact gaggagttga
     3841 aaaaatagat aggtagaaga taaccgttaa gccttattct tagcggttat ttatattgtt
     3901 taatagcgct gatatttcat caattatgcc tgttttcgtg tttctggtag ttgttcaagt
     3961 ttattgctac tatttttgat ggtatgaatg tgcttataat gtatcccggt taacgaaagt
     4021 tttggactta tactcttaga aaatctcttc aaaccacgtc aacgtcgcct tgccgtgcgt
     4081 atggttactg acttcgtcag ttctatccac aacctc
//
LOCUS       DAVLHC010000092         4009 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.093, whole genome shotgun sequence.
ACCESSION   DAVLHC010000092 DAVLHC010000000
VERSION     DAVLHC010000092.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4009)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4009)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4009
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.093"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            516..1379
                     /locus_tag="VXE25_002067"
     CDS             516..1379
                     /locus_tag="VXE25_002067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000572848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE/MutR family transcriptional regulator"
                     /protein_id="HEV0772456.1"
                     /translation="MIEKMELGEFYKELRLARKLKQSDVACDGLTASQLSKFELGQSM
                     LSADKLILAIQGINVTFDEFGHKLNNYQESPHMQIGRKVVDRFAHQDIAGLEQLLEEV
                     EQEQMAETYRRLNAIVIKDAIHSLDKSYPLAEEDSEFLTTYLYAIESWTWFELYLFCN
                     TLPFLSNQDLIFLSTSLLEKSKEFKELVHNRLYMKQGLLNIISELMERKLFSYIPIFE
                     AELESMLRPYDVFEKVLWQFLKKMSIFLQTKGSNQKEIEHFIQSLQVLENPQLIALFE
                     LRLQQYKKLID"
     gene            1665..1865
                     /locus_tag="VXE25_002068"
     CDS             1665..1865
                     /locus_tag="VXE25_002068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000933472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide pheromone VP1"
                     /protein_id="HEV0772457.1"
                     /translation="MLNLQFAETMELTEAELEIVYGGEFGNNAVIPAGAWGGFGTPWS
                     ITNFWKKNFNDRPDFDSDRRRY"
     gene            1932..2597
                     /locus_tag="VXE25_002069"
     CDS             1932..2597
                     /locus_tag="VXE25_002069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000720786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEV0772458.1"
                     /translation="MKKIISHRYFIIVFLLVIADQKFSVLVLRSDLVTGLSDFAYYLS
                     DMMLNFLVVLFALIAMIWSGKWQKINSRKFKGSYLFYSFLALLAFVVWNFVTFFLFPP
                     TRNEISYQHAAPTFTGATAFLMYFFYPVIAGPIFEEIIHRGLVMTALEKGKKWGLDVL
                     GSAILFGVSHISNHGWVLTDFVFYMGGGLIFAVLFRMTKSIYWPIGLHIVYNGIGQLL
                     MLL"
     gene            2669..3895
                     /locus_tag="VXE25_002070"
     CDS             2669..3895
                     /locus_tag="VXE25_002070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000862399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEV0772459.1"
                     /translation="MKVFLQNRDFRQLTINQWISTLGDTIFYLAFLNYVADASFAPLA
                     ILLITISETLPQVLQIFLGVLADFQHHRVLKYTVISFTKFLLYSIVSLSLSGQSFSLL
                     LVTFICMINLLSDTLSYFSGAMLTPIFIRIIGQDHLAEAIGFKQSTVSLVKTISNILG
                     GVLLGILSIQFISLLNALTFLIAFLGILFIKTDLLKVEKTISYQEGLSVKSFCQHLLQ
                     SSKLIWNMNKVLLVLFIISTSQAVINVTVPVSTLFLRNQPFLNLQTGQSLALLSTFEL
                     SALIVGSLVSGYLQHTISIKTALYASLVIQLLLLVGFATVRFDWILIFSTLDAFFAGV
                     LSPRLQELVFKQIPEESMGAVQSSISAITVVLPSLFTISLVTIATSFGTLAVSFVLLL
                     FLLVAFVMLLNIRESI"
BASE COUNT         1148 a          707 c          772 g         1382 t
ORIGIN      
        1 gaaaagaatt ttgaactatt tacaaaacaa agtgatctaa ttgttgcaaa tagatgggat
       61 aggggccttg aagcttataa agataaagtt tacacaaggg ggatctggat aagagattaa
      121 ctattgatat taaaaaggca ataatttata aaatttgtac aaaaaaatgt taaattttca
      181 cattttcata gtatactgtt taatagaaag taggttcttt gtaaccgctc cattataaaa
      241 tcctttcact cttccggtat actattagga aaaacataac tggaggatat tttgagctca
      301 cacctcatcg ttccagtggc tgttccccaa gctcgtgtac tgcccaaaaa agttagacat
      361 tctatttaga acgaggattg agttctgtat tgtacaaggc tcggtccttt tagagtcagc
      421 ttaaggctgg cttttttatt ttttctaact atcagaatat tttgacaaat gaacacaaat
      481 aatgatataa tatgcaaaag ctaggaggtg gtaggatgat tgaaaaaatg gaattggggg
      541 aattttacaa ggaattacgt ttggcgagaa agctcaagca gtcagatgtg gcttgtgacg
      601 ggctaacagc ttctcagttg tccaagtttg agctagggca gtccatgttg tctgctgata
      661 agctcatatt agccatccaa gggatcaatg tgacctttga tgagtttggg cacaagctca
      721 acaactatca agaatctcca catatgcaga ttggtagaaa ggttgtggat cgctttgctc
      781 atcaagatat agctggctta gagcaactgt tggaggaagt cgagcaagaa cagatggcag
      841 agacttatcg tcgtttgaat gctattgtaa tcaaagatgc catccactca ctagataaaa
      901 gctacccact agcagaggag gatagcgagt ttttgaccac ctatctctat gctatcgagt
      961 cttggacctg gtttgaactc tatctctttt gcaatactct gcccttcttg agcaatcaag
     1021 atctgatctt tttatcaacc tccttactcg aaaaatccaa agaatttaaa gagttagtac
     1081 acaatcgatt gtatatgaag caaggactct taaatatcat ctcagagctc atggagcgca
     1141 aacttttttc ttatatccca atctttgaag ccgagctgga gagtatgctc cgtccatacg
     1201 atgtttttga gaaagtgttg tggcagtttt taaagaagat gagcattttc cttcaaacta
     1261 agggaagcaa tcaaaaagag attgaacact ttatccaatc tctgcaagta ttagaaaatc
     1321 cacaattaat agcccttttt gaattgcgtt tgcagcaata caaaaagctt atcgattagt
     1381 tagaaatggc aaaataataa taatctcagc aacgattttc aataatgtta aaatttgttt
     1441 cttcatattt ctccactcct cattagtagt aactttatta taccagagaa gtaatcaaat
     1501 tcaccaaaat cgcaaatctg aaatttctat aagaaaaaat atcaaatatg cgattttcta
     1561 aaataagcca attttcgtgt tatactgtac ttgtaaagca cttgaagcaa atcctaggtc
     1621 acagaagtgg tttacaaatg aagataattg aaggagtgta aaagatgtta aatttacaat
     1681 ttgcagaaac aatggaattg acagaagctg agttggagat agtttatgga ggggaatttg
     1741 ggaataatgc tgttatccca gccggtgctt ggggagggtt cgggacacct tggtcaatca
     1801 ctaatttctg gaagaaaaat tttaacgata gacctgactt tgattctgac cgccgtcgtt
     1861 attaatatcc aaagcccttg ccttttcttg ggtaggggct gtctttattt catagtatag
     1921 gaggaaatag aatgaaaaag ataatctcac accgctactt tattatagtt tttctactag
     1981 ttattgctga ccagaagttc agtgttctag ttttacgcag cgaccttgtt actgggctat
     2041 ctgactttgc ctattatctg tcggatatga tgttgaattt tcttgtggtt ttatttgctc
     2101 ttattgctat gatttggtcg gggaaatggc agaaaatcaa tagtagaaag tttaaaggat
     2161 cctatctttt ctattccttc ctagctctgc ttgcttttgt tgtttggaat ttcgttacct
     2221 tttttctttt cccacctact cgaaatgaaa tttcttatca acatgctgct ccgactttta
     2281 caggggctac agcatttttg atgtattttt tctatcctgt gattgcaggt cccatttttg
     2341 aagagataat ccatcgggga ttggtgatga cagctctgga aaaaggaaag aaatgggggc
     2401 tagatgtact tggctctgct attttatttg gggtctcgca cattagtaat cacggttggg
     2461 tcttgacaga ctttgtcttc tatatgggtg gaggtcttat atttgcagtc ttatttagaa
     2521 tgacaaagtc aatttattgg cctattggac tgcatatagt ctacaatggt attggtcagc
     2581 ttttgatgtt actgtaattt tggttgttag tagtatcgcg gtctattctt ggggaaagat
     2641 tcccatttga acttaagaag gagttgtaat gaaagtattt cttcaaaata gagattttag
     2701 gcaattaact atcaaccagt ggatttcaac gcttggggat acgatttttt atctggcctt
     2761 cctgaattat gtggcagatg cgtcttttgc ccctttggcg attttactta tcacgatttc
     2821 agaaaccctt ccccaagttc tacaaatctt tctgggagtt ttggcggatt ttcaacatca
     2881 tcgtgtcttg aaatacacag tcattagttt tacaaaattt ttgctttact ctatagtgtc
     2941 cctatcgctt tcagggcagt ctttttcctt gttgctagta acctttattt gtatgattaa
     3001 cctcttgtct gacacattga gttatttttc aggcgccatg ctcactccga ttttcattag
     3061 aattattggg caagatcatc tggcagaagc tattggattt aaacagtcaa ctgttagttt
     3121 agtgaaaaca atcagtaata tcctaggagg agtcttacta ggtattctat ccatccagtt
     3181 tatttcctta ctgaacgctc ttaccttttt aatcgcattt ttaggtatcc tcttcataaa
     3241 aactgacctc ttgaaagtag aaaaaacgat tagctatcaa gaaggactct ctgtaaaatc
     3301 cttttgccag catttgctcc aatcatcgaa attgatatgg aatatgaata aggtgctctt
     3361 ggttttgttt attatctcta ctagtcaagc agtgataaat gttacagttc ctgtctctac
     3421 tctatttttg aggaatcaac cctttttgaa tttacaaaca ggtcaatctc ttgccttgct
     3481 atccactttt gaactgtcag ccctgattgt cggaagcctt gtaagtggct atctgcaaca
     3541 taccatttcc ataaaaacag ctctctatgc ctcacttgtc atccagttgc ttcttctagt
     3601 aggatttgcc acagttcgtt ttgactggat tctcatcttt agtaccttgg atgccttttt
     3661 cgcaggtgtt ctctctccta gattgcaaga actcgtcttt aaacaaatac ctgaggagtc
     3721 aatgggagca gttcaatctt ctatcagtgc cattacggtt gttttaccta gcttatttac
     3781 aatatctttg gtaaccattg ctactagctt tggaactctg gcagttagct ttgttttatt
     3841 gctatttctt ctagttgcct ttgttatgct tctgaatatt cgtgaaagta tttagtggag
     3901 aatttctata atatatgttt gagactggat tgccagtctt tttatgatgg tcaaaatcaa
     3961 cagacttttt ctcttttctg aatgtgttat agtagactga atctaaaat
//
LOCUS       DAVLHC010000093         3669 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.094, whole genome shotgun sequence.
ACCESSION   DAVLHC010000093 DAVLHC010000000
VERSION     DAVLHC010000093.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3669)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3669)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3669
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.094"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(173..1588)
                     /locus_tag="VXE25_002071"
     CDS             complement(173..1588)
                     /locus_tag="VXE25_002071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000151865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HEV0772460.1"
                     /translation="MTIFPDDFLWGGAVAANQVEGAYNEDGKGLSVQDVLPKGGLGEA
                     TENPTEDNLKLIGIDFYHKYKEDISLFSEMGFNVFRTSIAWSRIFPKGDEEEPNEAGL
                     KYYDELFDELHAHGIEPLVTLSHYETPLYLARKYHGWVDRRMIHFYEKFARTVLERYK
                     DKVKYWLTFNEVNSVLELPFTSGGIDIPKENLSKQELYQAIHHELVASSLVTKIAREI
                     NSEFKVGCMVLAMPAYPMTPNPKDVWATHEYENLNYLFSDVHVRGYYPNYAKRYFKEH
                     DINIEFAAEDAELLKNYTVDFLSFSYYMSVTQSALPTQYNSGEGNIIGGLVNPYLESS
                     EWGWQIDPIGLRIILNRYYDRYQIPLFIVENGLGAKDQLIKDELNNLTVQDDYRIQYM
                     KEHLLQVAEALQDGVEIMGYTSWGCIDCVSMSTAQLSKRYGLIYVDRNDDGNGTFNRY
                     KKMSFTWYKGVIESNGESLFK"
     gene            complement(1601..3439)
                     /locus_tag="VXE25_002072"
     CDS             complement(1601..3439)
                     /locus_tag="VXE25_002072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000120564.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HEV0772461.1"
                     /translation="MSYKDKVQKILDVIGGEKNVNRVTHCVTRLRLELKDENLVNDDD
                     MKKIPGVIGIMKKNGQYQIILGNDVANYYKEFVKLGNFESDSVVQGHKGNILERIIEY
                     IAGSMTPIIPAMLGGGMLKVLVIILPMLGILQSDSQTIAFLTFFGDAPYYFLPLLLAY
                     SASQKLKVTSTLAMSVAGVLLHPNFVQMVQSGNPLSLFGVPVTPASYGSSVVPILIMV
                     WLMKYIEKMIAKLTPAVTKSFLQPTLVLLVSSCIALVVVGPIGVIVGEGLSNLVGQMY
                     GVAGWLTLAILGAIMPFIVMTGMHWAFAPIFLAASIATPDVLILPAMLGSNLAQGAAS
                     MAVALKSKNNNTKQIAFAAGFSALLAGITEPALYGVTLKYKKPLYAAMIGGGLAGLFA
                     GLTSVKAYLFAVPSLIALPQFIYSDVPSNIVNALIVAVISVVITFVLAYIFGIDEEES
                     SSNLEVKAGVSNKKMIFSPISGEIIPLSDVQDKTFSDKLIGDGVAIIPSEGKVYAPFD
                     GKITNIFPTKHAIGLKSDEGVELLIHIGLDTVELKGQGFISHVEEGDRVFKNQLIFEM
                     DLNLIKTKGYETVTPVIVTNTNDFLDVLVLPNNQTIEHSKELLVIL"
     gene            complement(3457..>3669)
                     /locus_tag="VXE25_002073"
     CDS             complement(3457..>3669)
                     /locus_tag="VXE25_002073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006270038.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HEV0772462.1"
                     /translation="LFAHRLVENTTYCDDDDEDLLALMKNKYPREYECGEQVAMFIQT
                     EYNYLLTSSELVYLMAHIRRLTKNLD"
BASE COUNT         1230 a          741 c          488 g         1210 t
ORIGIN      
        1 cccatctatc ctaagttaac tatttataat cggctctctg taacaaaatt aaattaatta
       61 atccccctat aaaataaaga ggtttagaat ttgatgtctt ccaaacctct ttatttcata
      121 tttaatgaga tgttgcctta accgtgataa tatctaatca tcaataaaca aactatttga
      181 ataaggattc tccatttgat tcaatcactc ctttatacca agtaaaggac attttcttat
      241 atcgattgaa tgtgccattt ccatcatcat ttcgatcaac ataaatgaga ccgtaccttt
      301 tagaaagttg tgcagtggac atagaaacgc agtcaataca tccccaagat gtatagccca
      361 taatttcaac accatcctgt agagcttcag caacttgcaa taaatgttct ttcatatact
      421 gaattctata atcatcttgg acggttaagt tattaagttc atcttttatt agttgatctt
      481 tagcacctaa tccattttct actataaata atgggatttg ataacggtca taatatctat
      541 ttaaaattat acgtagtcca attggatcaa tttgccatcc ccactctgaa gactctaaat
      601 aaggatttac taaaccacca ataatattcc cttctcctga attatactgt gttggaagag
      661 cagattgagt cacactcatg taatagctaa aggataaaaa atctacggta taatttttta
      721 ataactctgc atcttcagct gcaaactcta tgttaatgtc atgttcctta aaatatcttt
      781 ttgcataatt cggataataa cctctaacat gcacatctga aaatagataa tttagattct
      841 catactcatg agtcgcccat acatcttttg gatttggagt cattggataa gctggcatag
      901 ctaataccat acaccccacc ttaaactctg aattaatctc acgagcaatt tttgtaacca
      961 aacttgaggc gactaattca tgatgtatag cttgatataa ttcttgtttc gaaagattct
     1021 ccttaggtat atctattcct ccactagtaa atggtaattc caaaacagag tttacttcgt
     1081 taaatgtaag ccaatattta actttatctt tatacctttc taaaactgtt cgagcaaatt
     1141 tttcataaaa atgaatcatt ctcctatcaa cccatccatg atattttctt gctaaatata
     1201 atggagtctc atagtgtgaa agagttacaa gtggctctat cccgtgagca tgtagttcat
     1261 caaacaattc atcataatat ttcaaaccag cttcgttagg ttcttcttca tctccttttg
     1321 gaaaaattct actccatgca atagaagtac gaaaaacatt aaagcccatt tcagaaaaca
     1381 aggatatatc ttccttatat ttatgataaa aatcaatacc tatcaatttt aagttatctt
     1441 ctgtaggatt ttctgttgct tctcctaatc cacctttggg taacacatcc tgaactgata
     1501 agcccttacc atcttcatta tatgctccct ctacttgatt agctgcaaca gctccacccc
     1561 aaagaaaatc atctggaaaa atggtcataa ctttcctcca ttataatatt accagtaatt
     1621 ccttagaatg ctcgattgtc tgattattag gtaatactaa tacatctaga aaatcattgg
     1681 tattcgttac aattactggt gtaactgttt cgtagccttt agtcttgatt aaattcaagt
     1741 ccatttcaaa aatcaactga tttttgaaaa ctctgtctcc ttcttctaca tgactaataa
     1801 aaccttgacc ttttagctca acagtatcta atccaatatg aattagtaac tcaacaccct
     1861 catcactctt caatccaatt gcgtgcttag tcggaaaaat atttgtaatt ttcccatcaa
     1921 atggtgcata aaccttacct tcacttggga taatcgctac tccgtctcca attagtttat
     1981 ctgaaaatgt tttatcctgg acatcgctta acggaatgat ttctcctgat ataggagaaa
     2041 atatcatttt tttatttgaa actccagctt taacttctaa attactagaa ctctcttctt
     2101 catcgattcc aaatatataa gctaatacaa aggtaataac aaccgaaatg accgccacaa
     2161 ttaaagcatt tacaatattt gatggtacat cagaataaat aaattgaggc aacgctatca
     2221 aagatgggac agcaaataga tacgctttaa cactagtaag acctgcaaat aatcccgcta
     2281 atccaccacc aatcatagct gcataaagcg gttttttata ttttaaagtc acaccatata
     2341 atgcaggttc ggtaattcct gcaagtaagg ctgagaaacc tgctgcaaaa gcaatttgtt
     2401 ttgtattatt atttttactc tttaatgcaa cagccatcga agcagcccct tgagctaagt
     2461 ttgaccctaa cattgctgga agaattaata cgtctggagt agcaatagat gccgccaaaa
     2521 aaataggtgc aaaagcccaa tgcattccag tcataacaat aaatggcata atagcaccaa
     2581 gaatagctaa tgtaagccat ccagctacac catacatttg cccaactaga tttgataatc
     2641 cttcaccaac aattactcca ataggtccga ctacaactaa ggcaatacag cttgatacta
     2701 ataatactag cgtaggttgc aaaaaactct tagtaacagc tggtgttaat ttagcaatca
     2761 ttttttcaat atatttcatc aaccaaacca taataagaat tggaacgact gacgaaccat
     2821 aactagctgg tgtcacaggt acaccaaata aactaagagg attccctgat tgcaccattt
     2881 gaacaaaatt tggatggaga agtacacctg ctacagacat agctaatgta gatgttactt
     2941 ttaatttttg tgatgcagaa taagctaata acagcggtaa gaaataatat ggcgcatccc
     3001 caaaaaatgt caaaaaagca atagtctgag aatctgattg caatatacca agcattggta
     3061 aaataattac caagactttc agcatacctc cccctaacat tgctggaatg attggagtca
     3121 tggaaccagc gatatactca atgattcttt ctaaaatatt ccctttgtgc ccttgaacaa
     3181 ctgaatcgga ttcaaaattg ccaagtttaa cgaattcttt ataataatta gctacatcat
     3241 taccaagtat aatttgatat tgtccattct ttttcataat acctattaca cctggtatct
     3301 tcttcatatc atcatcattg actaaatttt catcttttaa ttctaatctt aaacgtgtta
     3361 cacaatgggt aactctattg acattttttt cacctccaat tacatcgagg attttttgta
     3421 ccttatcttt ataactcatg gtattctcct attctattaa tctaaatttt ttgttaagcg
     3481 acgaatatga gccatcaaat aaactaattc actagaagtc agcaaataat tgtactcagt
     3541 ttgtataaac attgccacct gttcaccaca ttcatattct ctaggatatt tatttttcat
     3601 taatgctaac aagtcttcat catcatcgtc acaataagtt gtattttcaa ccaagcgatg
     3661 ggcaaataa
//
LOCUS       DAVLHC010000094         3660 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.095, whole genome shotgun sequence.
ACCESSION   DAVLHC010000094 DAVLHC010000000
VERSION     DAVLHC010000094.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3660)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3660)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3660
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.095"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(252..545)
                     /gene="rpmA"
                     /locus_tag="VXE25_002074"
     CDS             complement(252..545)
                     /gene="rpmA"
                     /locus_tag="VXE25_002074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018376869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L27"
                     /protein_id="HEV0772463.1"
                     /translation="MLKMTLNNLQLFAHKKGGGSTSNGRDSQAKRLGAKAADGQTVTG
                     GSILYRQRGTHIYPGVNVGRGGDDTLFAKVEGVVRFERKGRDKKQVSVYPIAK"
     gene            complement(562..906)
                     /locus_tag="VXE25_002075"
     CDS             complement(562..906)
                     /locus_tag="VXE25_002075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000613691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal-processing cysteine protease Prp"
                     /protein_id="HEV0772464.1"
                     /translation="MIQAVFERAEDGELRSAEITGHAESGEYGLDVVCASVSTLAINF
                     INSIEKFAGYEPILELNEDEGGYLMVEIPKDLPSHQREMTQLFFESFFLGMANLSENS
                     SEFVQTRVITEN"
     gene            complement(922..1236)
                     /gene="rplU"
                     /locus_tag="VXE25_002076"
     CDS             complement(922..1236)
                     /gene="rplU"
                     /locus_tag="VXE25_002076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018374562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L21"
                     /protein_id="HEV0772465.1"
                     /translation="MSTYAIIKTGGKQVKVEVGQAVYVEKLNVEAGQEVTFNEVVLVG
                     GENTVVGTPLVAGATVVGTVEKQGKQKKVVTYKYKPKKGSHRKQGHRQPYTKVVINAI
                     NA"
     misc_feature    complement(1272..1359)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00559"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="ribosomal protein L21 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00559"
     gene            complement(1418..2053)
                     /locus_tag="VXE25_002077"
     CDS             complement(1418..2053)
                     /locus_tag="VXE25_002077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001856695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1275 domain-containing protein"
                     /protein_id="HEV0772466.1"
                     /translation="MTFCAGYVDAYTFIVRGNILVAGQAGNVVFLSVELIQNNVSDIR
                     DKLLTLIAFMMGVFLLTIYKEKLRIVKKSILSLIPLAILSIIIGFVPQTVDNIYLVPP
                     LAFCMGLVTTAFGEVSGIAYNNAFMTGNIKRTMLAFGDYFRTKHTPFLREGFIFVSLL
                     SSFVLGVVFSAYLTIFYHEKTILGVPIMMSVFYLSMLFASWQKKVKEKASF"
     gene            2524..2823
                     /locus_tag="VXE25_002078"
     CDS             2524..2823
                     /locus_tag="VXE25_002078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YbaB/EbfC family nucleoid-associated protein"
                     /protein_id="HEV0772467.1"
                     /translation="MMNMQNMMRQAQKLQKQMEQSQAELAAMQFVGKSAQDLVQATLT
                     GDKKVVSIDFNPAVVDPEDLETLSDMTVQAINSALEQIDETTKKKLGAFAGKLPF"
     gene            3042..3660
                     /locus_tag="VXE25_002079"
                     /pseudo
     CDS             3042..3660
                     /locus_tag="VXE25_002079"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436408.1"
                     /note="frameshifted; incomplete; missing C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
BASE COUNT         1193 a          742 c          635 g         1090 t
ORIGIN      
        1 ggggtgaata attggggtta aagtgcaaac taggaagtta gccgcaggct gtacttgagt
       61 acggcaaggt gaaactgacg tggtttgaat ttgattttcg aagagtatca atccactata
      121 catattaaaa gtatggatat caaaacaaaa aaacaggctc tccgaaaact cggaaagcct
      181 tattttaagc tgtttctagc ttcctcacct ttacatttca aggttcggga taaaaggttc
      241 aatggacctt tttatttagc gattgggtaa acagaaactt gttttttatc gcgtccttta
      301 cgttcaaagc gtactacgcc ttcaacttta gcgaacaaag tatcgtctcc accacgacca
      361 acgtttacac ctggatagat gtgtgtacca cgttgacggt aaaggattga tccacctgtt
      421 acagtttgtc cgtcagctgc tttagctcca agacgtttcg cttgtgaatc acgtccgttt
      481 gatgtagaac ctccaccttt tttgtgggcg aaaagttgca agttgttaag agtcattttt
      541 aacataatgt tttcctccgt gttagttttc tgtgataact ctggtttgga cgaactcaga
      601 agagttctcc gataagtttg ccatacctaa gaaaaatgat tcaaagaata actgggtcat
      661 ttctctctgg tgtgaaggaa gatcttttgg tatttcaacc atcagatagc caccttcatc
      721 ttcgtttaat tctaggattg gttcatagcc tgcaaatttc tcaatagaat tgataaagtt
      781 aatggcaagc gtagaaaccg atgcacacac gacatctaag ccgtattcgc cactctcggc
      841 gtgtccagta atttccgcac tcctcagctc gccatcttcg gctctctcaa agactgcctg
      901 tatcatgtgt tctccttaaa attaagcgtt gattgcgttg atgacaactt ttgtatatgg
      961 ttgacggtga ccttgtttac ggtggctacc ttttttaggt ttgtacttgt aagtaaccac
     1021 tttcttttgt tttccttgtt tttcaacagt tccaactaca gtagctccag caacaagtgg
     1081 agttccgaca acagtgtttt caccaccaac aagaacaact tcgttaaaag taacttcttg
     1141 accagcttca acgttcaatt tttcaacgta aactgcttga ccaacttcaa ctttaacttg
     1201 ttttccgcca gttttgataa ttgcgtatgt gctcattatg cacctcctat gatttttatg
     1261 ggtttccccg attttttgtg aagactcgcc tagcatcgtg ggacgaacca cttaaacttg
     1321 aataatcaag caacgatgtt cgtgcggttg cacaggatcg tgcatagtca actcttcaag
     1381 tatagcatat ctcctatttt cttacaagta ataacaccta aaatgaagct ttttctttta
     1441 cttttttctg ccaagaggca aaaagcatgc tgaggtaaaa aacgctcatc ataataggaa
     1501 caccaagaat ggtcttttca tgatagaaaa tcgtcaaata ggctgaaaag acaacgccaa
     1561 ggacaaaact actaagcagg ctaacaaata tgaatccttc acgcaaaaaa ggagtgtgct
     1621 tggttcggaa ataatctcca aaagccagca tggtccgttt gatattccct gtcataaaag
     1681 cgttattata ggcaataccc gacacttctc caaaagcagt tgtcaccagt cccatacaga
     1741 aggccaaggg cggcactaga tagatattat ctacagtttg tggcacaaaa ccaataatta
     1801 ttgataggat tgctaaagga atcaaggaca gaatagattt tttcacaatt ctcaattttt
     1861 ccttataaat cgttaataaa aagactccca tcataaacgc tattaaggtt aaaagcttat
     1921 ccctaatatc cgaaacatta ttttgtatga gctctaccga aagaaagaca acatttccag
     1981 cttgtccagc tacaaggata ttcccgcgaa caataaaagt gtaagcatcc acatatccag
     2041 cacaaaacgt caaaaaagtg ctaacctttt agactgacgt gatatttttc ttataggtaa
     2101 taacctcatt ttccctccca ttgtattttc tcttagaaat attgtaccat tttctttcta
     2161 aaaaatcgta ggctaccatt tagattttac tattagcata aaaataataa tagacaacta
     2221 tttatccaaa aatagataga ggtaacatgt ttgcaaacaa agcatacgaa cctttagtaa
     2281 aatcatttcc atgaaactag aatagagccc ctcttagcaa aaatcattat tttaatttat
     2341 ttctaatcac tccttgacat aaataactct caccaataaa agactatgtc ttaaaaaaat
     2401 ggtataataa aatcaatact tgggcttgat ggctatgcta ctaataacaa ttaggagaga
     2461 aaatcaggca cttgttaaca acaaggatta tccccttgag atgaaaggaa ctttagaaat
     2521 cttatgatga acatgcaaaa catgatgcgt caagcacaaa aacttcaaaa acaaatggaa
     2581 caaagccaag ctgaacttgc tgctatgcaa tttgttggca aatctgctca agatcttgtc
     2641 caagcaacct taactggcga taagaaagtt gtcagcattg atttcaatcc agctgtcgtt
     2701 gacccagaag accttgagac tctttctgat atgaccgttc aagccatcaa ctctgctctt
     2761 gaacaaatcg atgaaactac taagaaaaaa ctgggtgctt tcgctgggaa attgccattc
     2821 taaaaacaag gagctagaac aatgcttgtc gataacaaag gctaagaaag gtgcaaaaat
     2881 tataaaaaac gcatagtatc aagcaaccta aaactttggg ctctataata tttgtagtgg
     2941 gtaaatcccc tatagatatt atggagccta ttttgtgtag aaaaaaagtc ccatatgacc
     3001 tataatgaaa agcgacaaaa caactcatta gaaagaatca tatggaacaa ttacatttta
     3061 tcacaaaatt actagacatt aaagacccta atatccagat tttagacatc atcaataagg
     3121 atacacacaa ggaaatcatc gccaaactgg actatgaagc tccatcttgc cctgagtgcg
     3181 gaagtcaaat gaagaaatat gactttcaaa aaccttctaa aattccttat cttgaaacaa
     3241 ctggtatgcc tactagaatt ctccttagaa agcgtcgttt caagtgctat cattgttcta
     3301 aaatgatggt tgctgaaact tctatcgtca agaagaatca tcaaatccct cgtatcatca
     3361 accaaaagat tgctcaaaag ttaattgaaa agaattctat gaccgatatt gcccatcagc
     3421 tggccatctc aacttcaact gttattcgta agctcaatga ttttcacttt aaacatgatt
     3481 tttcgcgtct tcctgagatt atgtcttggg acgttgaaac agtccgggga gtgactgttt
     3541 caatcgggag atggagatga gcttcattgc gcaagatttt aacaatctca atatcatcac
     3601 tgttcttgag ggaagaacac aagctatcat tcgaaatcac tttcttcgct acgatagagc
//
LOCUS       DAVLHC010000095         3369 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.096, whole genome shotgun sequence.
ACCESSION   DAVLHC010000095 DAVLHC010000000
VERSION     DAVLHC010000095.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3369)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3369)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3369
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.096"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(128..358)
                     /locus_tag="VXE25_002080"
     CDS             complement(128..358)
                     /locus_tag="VXE25_002080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000252078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772468.1"
                     /translation="MVRNKIGDLTNTLFAQLETLDDRDLTADELKVELQRSKQMVAIS
                     GQILQAGQLALDAEKFKDKVGEVNAPIALLEG"
     gene            complement(359..700)
                     /locus_tag="VXE25_002081"
     CDS             complement(359..700)
                     /locus_tag="VXE25_002081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000189404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772469.1"
                     /translation="MTQAEQIREYYREHPAASCDEVAEVVGTTKSNVSANLAKDIKAG
                     RCVRLEDKSYDYSPYFNHTQALTELVDWKNDTRREWVDMLTRAAEKETDSNVMRLLIK
                     EANKLMKEVTK"
     gene            complement(712..903)
                     /locus_tag="VXE25_002082"
     CDS             complement(712..903)
                     /locus_tag="VXE25_002082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000970850.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772470.1"
                     /translation="MMEYIYLVIIVGIGLWSLVNKLDDHAEMKQKERQLMANNVARMN
                     LRNSDKQFTYDVEPPEGLK"
     gene            complement(900..1094)
                     /locus_tag="VXE25_002083"
     CDS             complement(900..1094)
                     /locus_tag="VXE25_002083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001050924.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772471.1"
                     /translation="MNLLSRIKNYFSEEVKETNLDWKEVALDLNQSLIETQEKLQEAN
                     QEIADLKKIVAIYKEKEKEK"
     gene            complement(1091..1363)
                     /locus_tag="VXE25_002084"
     CDS             complement(1091..1363)
                     /locus_tag="VXE25_002084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000388508.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772472.1"
                     /translation="MEVVEIVRIKDVIIEKVSANDEELKRIFGCSKRQAGERRREMQK
                     LPSQQKHLLDSGQLVTIKGFYEYLQYRGTKAWKKEMETSKKMRSAG"
     gene            complement(1442..1585)
                     /locus_tag="VXE25_002085"
     CDS             complement(1442..1585)
                     /locus_tag="VXE25_002085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000389591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772473.1"
                     /translation="MEDKIIELADYFISESTTYREAKIACEKLLKQVSHEIELRAMES
                     RTV"
     gene            1704..1895
                     /locus_tag="VXE25_002086"
     CDS             1704..1895
                     /locus_tag="VXE25_002086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000834563.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772474.1"
                     /translation="MKSFKDFRESLTAEDMQAISAKANEATKQIDHTDGLQLGKVSGL
                     TSVITTVELLEKYHEWLHS"
     gene            complement(2078..2269)
                     /locus_tag="VXE25_002087"
     CDS             complement(2078..2269)
                     /locus_tag="VXE25_002087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001112859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HEV0772475.1"
                     /translation="MPDIANGRERVIAFLKEKGIKKATLAVAYGFKRQEVTNILSGTT
                     KGPRANSFILQVIEDYGIE"
     gene            2334..2573
                     /locus_tag="VXE25_002088"
     CDS             2334..2573
                     /locus_tag="VXE25_002088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000142894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772476.1"
                     /translation="MTFKEYLLKASKRDIYDDGKDFDFETIFAREILRYAHDSELETK
                     TGFFRHLEIMNADSWFVELARSIYQDFEKSISDSH"
     gene            2797..2886
                     /locus_tag="VXE25_002089"
     CDS             2797..2886
                     /locus_tag="VXE25_002089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019771180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I addiction module toxin, Fst family"
                     /protein_id="HEV0772477.1"
                     /translation="MVDYIFTNIILPLVVGIVLIVIEKWLNKK"
     gene            3109..3201
                     /locus_tag="VXE25_002090"
     CDS             3109..3201
                     /locus_tag="VXE25_002090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="HEV0772478.1"
                     /translation="MMELILKTIIGPIVVGVVLRLADKWLNKDK"
BASE COUNT          879 a          721 c          564 g         1205 t
ORIGIN      
        1 ccctagacgt ttgcgtacgc caccgatttg actcttgtta taattcgtac caaatttttc
       61 attcagcaac ctggttactt caggagttaa acgaccaggg catatttcat gcatgtactc
      121 cgtgtactca tccttccagc aaagcgatcg gggcattgac ttcacctacc ttgtctttga
      181 atttttcagc atctagcgcc aattgacctg cttgtaagat ttgacctgag attgcgacca
      241 tttgtttcga gcgctgtaat tctactttta attcatctgc tgtaagatcc ctatcatcca
      301 gagtctctaa ttgagcgaag agcgtgttag ttaaatcacc tattttattt cgtaccatct
      361 acttagtcac ctctttcatc aatttatttg cttctttgat taacaaacgc ataacgttgc
      421 tatccgtttc tttctctgct gctcttgtca gcatatccac ccactcacgt ctggtatcat
      481 tcttccaatc aaccaactca gtgagcgctt gtgtgtgatt aaagtaaggg gagtagtcgt
      541 atgacttgtc ttccaagcga acgcatctgc ctgccttgat gtctttggcc aggtttgcac
      601 ttacgttgct ttttgttgta ccgacaacct cagccacttc atcacatgag gcagcagggt
      661 gctctctata atattcccta atttgttccg cttgagtcat gtttctcctc cttatttcaa
      721 cccttcaggc ggttctacat cataagtaaa ttgcttatct gaatttctca gattcatccg
      781 tgcgacattg tttgccatca gctggcgctc tttttgtttc atttcagcgt ggtcatctag
      841 tttatttact agcgaccata gtccaattcc tacgattatt accaggtaaa tgtattccat
      901 catttttctt tctccttttc tttgtagatt gctacgattt tcttcaagtc tgcgatttct
      961 tgattcgctt cttgaagttt ttcctgtgtt tcaattagtg attgattgag gtctaaagcg
     1021 acctctttcc agtcgagatt agtttctttg acctcttccg aaaaatagtt tttgattctt
     1081 gatagtaggt tcatcctgct gacctcattt tcttgcttgt ttccatttct tttttccaag
     1141 ctttagttcc acgatattgc aagtattcat agaaaccttt aatcgttaca agttgtccac
     1201 tatccaaaag atgtttttgc tgactaggga gtttttgcat ttctcttctt cgctctcctg
     1261 cttgtcgttt tgaacatcca aagatacgtt ttaactcttc atcattagca gagacttttt
     1321 caataatcac atctttaatt cttacaattt caactacttc catttttgct cctttcgtgt
     1381 tataatcatg ttgaatattt aagtatgcgc ctgatttccg tcaggtgctt tttgttgtct
     1441 tctagactgt cctactttcc atcgccctga gttctatctc atggctgact tgtttcaata
     1501 gcttctcaca cgctattttt gcttctctgt acgttgtaga ttcgctgatg aagtaatcag
     1561 caagttctat gattttatct tccaatattg cctccaaaaa tcagcctcaa gaccgatgta
     1621 atatcctcct aaattgctat aataatctcg actaggacct ctcaccgttt tagtcaaaat
     1681 tccaatagaa aggaggagtt tttatgaaat cctttaaaga ttttcgagaa tctttaacag
     1741 ctgaagatat gcaagctatc tctgctaaag ctaatgaagc tactaaacag attgaccata
     1801 cagacggatt gcaactgggg aaggtcagtg gtttgacttc tgtaataact actgttgagt
     1861 tacttgagaa gtatcatgaa tggcttcata gctaagacgc ttaaattctt ctaagtctat
     1921 ctgaaaattg ataggctttt tttgtaaaca ctcaagaaaa ctagtgtttc ttaaaagttt
     1981 ttcaactaac tcagggtcgg cctttacaaa ggtggactct tttttcccac tatacggata
     2041 tcgtcttggt ctcattttcc tactcctcaa atctttccta ctcaatccca taatcttcaa
     2101 taacctgaag aatgaaactg ttcgctcgtg gacctttagt cgttccactt agaatgtttg
     2161 tcacttcctg tcgtttaaag ccgtaagcaa ccgctagagt tgctttttta atgcctttct
     2221 ctttcaagaa agcaataact ctttcgcgac cgtttgcaat atctggcata ttttctcctt
     2281 tctttttctt tcttcttttt ctgctataat ataagcagaa aggagttaac cttatgactt
     2341 ttaaagaata tttactcaaa gcaagcaaac gcgacatcta cgatgatggt aaagattttg
     2401 attttgaaac catctttgct agagaaatat tacgttatgc acacgattct gaactggaaa
     2461 ccaaaacagg tttctttcgt catcttgaaa tcatgaatgc tgattcgtgg tttgttgaac
     2521 ttgctcgctc aatttatcaa gattttgaga aatcaatttc agattctcac taatcgagcg
     2581 tgactttttt tgatatggca atctcagaaa tttaccacca gcgctgacta ccttaatgat
     2641 tttttcaagg tggtcttttt cttgttctaa atttttaaga atacttacca tcgacacgtt
     2701 cctccttttt tcaaaaataa aaaatgccct atctaactga tagagcatgt ggtataatag
     2761 tgacggcaca tctgccttag aagggaggtg gagcctatgg tagattacat cttcacaaat
     2821 attattctac ccttggtggt cggtatcgtc ctgatagtca tcgaaaaatg gctaaacaag
     2881 aaatagcgac taacccacct ttctagcgta gactagaaaa agcccttgct tttgtggtta
     2941 tcagcagggg cttttttgta gttgtagtag actacatctt cacttcccct atattatctc
     3001 acatctattt taagttgtca aaagaaacct ttgacaagct gaattagaaa tgtggtataa
     3061 tattttacgg cacttctaca ccgcctacga aaggaggtga gatagcccat gatggaacta
     3121 atccttaaaa ctatcatcgg accgattgtg gtcggtgtcg ttcttcgttt agctgataaa
     3181 tggctgaaca aggacaaata gtgtcaaaaa aagaccccaa gcttaatgtg gaagttagcc
     3241 tggggtcttt tctagtccat gatatagaac taatccttaa ttccccttta ttatctcaca
     3301 tgctctattc aattgtcaag gaacaagtaa acaagaaaca actaaaaatg taactatttt
     3361 ttgtacttt
//
LOCUS       DAVLHC010000096         3294 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.097, whole genome shotgun sequence.
ACCESSION   DAVLHC010000096 DAVLHC010000000
VERSION     DAVLHC010000096.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3294)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3294)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3294
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.097"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            35..1369
                     /locus_tag="VXE25_002091"
     CDS             35..1369
                     /locus_tag="VXE25_002091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001833303.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HEV0772479.1"
                     /translation="MKLWDLILLGIGAMVGTGVFTITGTAAATLAGPALVISIVISAL
                     CVGLSALFFAEFASRVPATGGAYSYLYAILGEFPAWLAGWLTMMEFMTAISGVASGWA
                     AYFKGLLSQYGIALPQALNGTFNPQAGTFVDLLPILVLVLVTSLVLLNAKAALRFNSI
                     LVILKFSALALFVLVGIWNIKFDNWSNFAPYGFGQIYGASTGIMAGASLMFFGFLGFE
                     SISMAVDEVKTPQKNIPRGIVLSLSIVTILYALVTLVLTGVVHYSHLNVDDAVAFALR
                     SVGISWAANYVSLVAILTLITVCISMTYALSRMIYSLARDGLVPAAFKELTKTSKIPK
                     NATILTGLASAVAAGMFPLASIAAFLNICTLAYLIMLAYGLIRLRKEKGMPKAGEFKT
                     PLVPLLPILSIIICLSFMLQYNMNTWIAFLVALLVGSIIYFTYGYKHSTIEE"
     gene            1512..2429
                     /gene="adcAII"
                     /locus_tag="VXE25_002092"
     CDS             1512..2429
                     /gene="adcAII"
                     /locus_tag="VXE25_002092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000744528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-binding lipoprotein AdcAII"
                     /protein_id="HEV0772480.1"
                     /translation="MKKQNLFLVLLSVFLLCLGACGQKESQTGKGMKIVTSFYPIYAM
                     VKEVSGDLNDVRMIQSSSGIHSFEPSANDIAAIYDADVFVYHSHTLESWAGSLDPNLK
                     KSKVKVLEASEGMTLERVPGLEDVEAGDGVDEKTLYDPHTWLDPEKAGEEAQIIADKL
                     SEVDSEHKETYQKNAQAFIKKAQELTKKFQPKFEKATQKTFVTQHTAFSYLAKRFGLN
                     QLGIAGISPEQEPSPRQLTEIQEFVKTYKVKTIFTESNASSKVAETLVKSTGVGLKTL
                     NPLESDPQNDKTYLENLEENMSILAEELK"
     gene            2437..>3294
                     /gene="phtD"
                     /locus_tag="VXE25_002093"
     CDS             2437..>3294
                     /gene="phtD"
                     /locus_tag="VXE25_002093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal histidine triad protein PhtD"
                     /protein_id="HEV0772481.1"
                     /translation="MKINKKYLAGSVAVLALSVCSYELGRHQAGQVKKESNRVSYIDG
                     DQAGQKAENLTPDEVSKREGINAEQIVIKITDQGYVTSHGDHYHYYNGKVPYDAIISE
                     ELLMKDPNYQLKDSDIVNEIKGGYVIKVDGKYYVYLKDAAHADNIRTKEEIKRQKQER
                     SHNHNSRADNAVAAARAQGRYTTDDGYIFNASDIIEDTGDAYIVPHGNHFHYIPKSDL
                     SASELAAAQAYWNGKQGSRPSSSSSHNANPAQPRLSENHNLTVTPTYHQNQGENISSL
                     LRELYAKPLS"
BASE COUNT          970 a          608 c          707 g         1009 t
ORIGIN      
        1 tgttagttta gataaaacag agatgcatag gcatttgaag ttatgggatt tgattttgct
       61 gggtatcgga gccatggtag ggacaggcgt ctttacaatc acaggtactg cagctgcaac
      121 acttgctggc ccagccctag tgatttcaat cgttatttct gccttgtgtg tgggattatc
      181 agccctcttt tttgcagaat ttgcctcgcg agtacccgct acaggaggtg cctatagtta
      241 cctctatgct atcttaggag aattccctgc ctggttggct ggttggttaa ccatgatgga
      301 gttcatgaca gccatatcag gcgtagcttc gggttgggca gcttatttta aaggcttgct
      361 ctctcaatac gggatagccc ttcctcaggc tttaaatggt acctttaatc ctcaagcagg
      421 gacatttgtt gatttattgc ctattcttgt cttggtcttg gtgacttcgc ttgttttact
      481 aaatgccaag gcagccttac gctttaattc gattctagtt attttgaaat tttccgcttt
      541 agctctcttt gttttagtag gaatttggaa tattaagttt gataattgga gcaattttgc
      601 tccttacggt tttggacaaa tctatggagc tagcactggt attatggctg gtgcgtcctt
      661 gatgttcttc ggttttttgg gatttgaatc catctctatg gctgtagatg aagtcaagac
      721 tcctcaaaaa aatattccta gagggattgt cttatcgctt tctatcgtaa ccattctcta
      781 tgccttggtg acccttgttt tgactggtgt ggttcactat agtcatttaa atgtcgatga
      841 tgccgttgcc tttgcccttc gtagtgttgg gattagttgg gcagccaact atgtgtcatt
      901 agtggctatc ttgaccttga ttacagtttg tatttcgatg acctatgccc tatcgcgtat
      961 gatttacagt ttagcacgtg acggcttagt gcctgctgcc tttaaggaac tgacgaagac
     1021 tagcaagata ccaaagaatg ctactatctt gacaggtcta gcttcagcag tagcagcagg
     1081 aatgttccca ctagccagta ttgcagcctt tttaaatatt tgtaccttag cctacttgat
     1141 catgttggct tatggtctga ttcgcttacg gaaagaaaaa ggaatgccca aagctgggga
     1201 atttaaaaca ccattggtac ctctgttacc aattttatcg atcatcattt gtttatcctt
     1261 catgttacag tataatatga atacctggat tgctttccta gttgcgttgt tagtaggaag
     1321 tattatttac ttcacttatg gctataagca ttctaccata gaagaataaa gtgaaagtct
     1381 attgagttgt tgacactcag cagattttta tatgtgaaag aaatttcaaa ttttttctaa
     1441 aaatatcttg acagattaaa ttttcaggag tagaatattt actagttaat taaatggtta
     1501 aggagttgtt catgaagaaa caaaatttat ttttagtcct gttaagtgtc tttcttttgt
     1561 gcttgggggc ttgtggtcaa aaggaaagtc agacaggaaa ggggatgaaa attgtgacca
     1621 gtttttatcc tatctacgct atggttaagg aagtatctgg tgacttgaat gatgttcgga
     1681 tgattcagtc aagtagtggt attcactcct ttgaaccttc ggcaaatgat atcgcagcca
     1741 tctatgatgc agatgtcttt gtttaccatt ctcatacact cgaatcttgg gcaggaagtc
     1801 tggatccaaa tctaaaaaaa tccaaagtga aggtcttaga ggcttctgag ggaatgacct
     1861 tggaacgtgt ccctggacta gaggatgtgg aagcagggga tggagttgat gaaaaaacgc
     1921 tctatgaccc tcacacatgg ctagatcctg aaaaagctgg agaagaagcc caaattatcg
     1981 ctgataaact ttcagaggtg gatagtgagc ataaagagac ttatcaaaaa aatgcgcaag
     2041 cctttatcaa aaaagctcag gaattgacta agaaattcca accaaaattt gaaaaagcga
     2101 ctcagaaaac atttgtaaca caacatacag ccttttctta tctagcgaag agatttgggc
     2161 ttaatcaact tggtattgca ggtatctctc ctgaacaaga accaagtcca cgacaactaa
     2221 cagaaattca ggaatttgtt aagacctata aggttaaaac gatttttaca gaaagtaacg
     2281 cttcttcaaa agtagctgaa actcttgtca aatcaacagg tgtgggtctt aaaactctga
     2341 atcctttaga gtcagaccca caaaatgaca agacctattt agaaaatctt gaagaaaata
     2401 tgagtattct agcagaagaa ttaaagtgag gaaagaatga aaatcaataa aaaatatcta
     2461 gcaggttcag tggcagtcct tgccctaagt gtttgttcct atgaacttgg tcgtcaccaa
     2521 gctggtcagg ttaagaaaga gtctaatcga gtttcttata tagatggtga tcaggctggt
     2581 caaaaggcag aaaatttgac accagatgaa gtcagtaaga gagaggggat caacgccgaa
     2641 caaattgtta tcaagattac ggatcaaggt tatgtgacct ctcatggaga ccattatcat
     2701 tactataatg gcaaggttcc ttatgatgcc atcatcagtg aagaacttct catgaaagat
     2761 ccgaattatc agttgaagga ttcagacatt gtcaatgaaa tcaagggtgg ctatgtgatt
     2821 aaggtagacg gaaaatacta tgtttacctt aaagatgcgg cccatgcgga caatattcgg
     2881 acaaaagaag agattaaacg tcagaagcag gaacgcagtc ataatcataa ctcaagagca
     2941 gataatgctg ttgctgcagc cagagcccaa ggacgctata caacggatga tggttatatc
     3001 ttcaatgcat ctgatatcat cgaagatacg ggcgatgcct atatcgttcc tcatggcaat
     3061 cacttccact atattcctaa gagtgattta tctgccagtg aattagctgc tgcccaagcc
     3121 tattggaatg ggaagcaggg atctcgtcct tcttcaagtt ctagtcataa tgcaaatcca
     3181 gctcaaccaa gattgtcaga gaaccacaat ctgactgtca ctccaactta tcatcaaaat
     3241 caaggggaaa acatttcaag ccttttacgt gaattgtatg ctaaaccctt atca
//
LOCUS       DAVLHC010000097         3241 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.098, whole genome shotgun sequence.
ACCESSION   DAVLHC010000097 DAVLHC010000000
VERSION     DAVLHC010000097.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3241)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3241)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3241
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.098"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(189..800)
                     /gene="rpsD"
                     /locus_tag="VXE25_002094"
     CDS             complement(189..800)
                     /gene="rpsD"
                     /locus_tag="VXE25_002094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407971.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S4"
                     /protein_id="HEV0772482.1"
                     /translation="MSRYTGPSWKQARRLGLSLTGTGKELARRNYVPGQHGPNNRSKL
                     SEYGLQLAEKQKLRFTYGVGEKQFRNLFVQATKIKGGILGFNFMLLLERRLDNVVYRL
                     GLATTRRQARQFVNHGHILVDGKRVDIPSYRVTPGQVISVREKSLKVPAILEAVEATL
                     GRPAFVSFDAEKLEGSLTRLPERDEINPEINEALVVEFYNKML"
     gene            complement(995..2047)
                     /locus_tag="VXE25_002095"
     CDS             complement(995..2047)
                     /locus_tag="VXE25_002095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000769768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HEV0772483.1"
                     /translation="MKLKSYILVGYIISTLLTILVVFWAVQKMLIAKGEIYFLLGMTI
                     VASLVGAGISLFLLLPVFTSLGKLKEHAKRVAAKDFPSNLEVQGPVEFQQLGQTFNEM
                     SHDLQVSFDSLEESEREKGLMIAQLSHDIKTPITSIQATVEGILDGIIKESEQAHYLA
                     TIGRQTERLNKLVEELNFLTLNTARNQVETTSKDSIFLDKLLIECMSEFQFLIEQERR
                     DVHLQVIPESARIEGDYAKLSRILVNLVDNAFKYSAPGTKLEVVTKLEKGQLSISVTD
                     EGQGIAPEDLENIFKRLYRVETSRNMKTGGHGLGLAIARELAHQLGGEITVSSQYGLG
                     STFTLVLNLSGSENKA"
     gene            complement(2044..2742)
                     /locus_tag="VXE25_002096"
     CDS             complement(2044..2742)
                     /locus_tag="VXE25_002096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000520636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEV0772484.1"
                     /translation="MGKTILLVDDEVEITDIHQRYLIQAGYQVLVAHDGLEALELFKK
                     KPIDLIITDVMMPRMDGYDLISEVQYLSPEQPFLFITAKTSEQDKIYGLSLGADDFIA
                     KPFSPRELVLRVHNILRRLHRGGETELISLGNLKMNHSSHEVQIGEEMLDLTVKSFEL
                     LWILASNPERVFSKTDLYEKIWKEDYVDDTNTLNVHIHALRQELAKYSSDQTPTIKTV
                     WGLGYKIEKPRGQT"
     gene            complement(2909..>3241)
                     /locus_tag="VXE25_002097"
     CDS             complement(2909..>3241)
                     /locus_tag="VXE25_002097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000671383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG cell wall anchor domain-containing
                     protein"
                     /protein_id="HEV0772485.1"
                     /translation="INVKETSDTANGSLSPSNSGSSVTPMNHNHAPGTTDSVPADTMT
                     SSTNTMAGENMAASANKMSDTMMSEDKAMLPNTGETQTSMASIGFLGLALAGLLGGLG
                     LKNKKEEN"
BASE COUNT          908 a          729 c          622 g          982 t
ORIGIN      
        1 gaatatgcca taaaaggatt ataccacatt gtgtactatt tttggttcat tttactatat
       61 cactttggac tatatcggtc tagttatgtc tcaacgatta tagctggata ctaagagaaa
      121 tcaaaaaagc actaagggag aacgtcccaa agtgcttaat atcaaagcct atcttattca
      181 ataaaatatt acaacatttt gttgtagaat tcaacgacaa gtgcttcgtt gatttctggg
      241 ttgatttcgt cgcgttctgg caagcgagtc aatgaacctt ccaacttttc agcgtcgaat
      301 gatacgaatg ctggacgtcc aagagtagct tctactgctt caaggattgc tggaactttc
      361 aatgattttt cacgaactga gattacttga cctggagtta cgcggtatga tgggatatca
      421 acgcgtttcc cgtcaacaag gatgtgaccg tggtttacga attgacgagc ttgacgacga
      481 gtagtcgcga gaccaagacg gtaaacaacg ttatccaaac gacgttccaa aagaagcata
      541 aagttgaaac ctaggattcc gcctttgatt tttgtagctt gtacgaacaa gttacggaat
      601 tgtttttcac ctacaccgta agtgaaacga agtttttgtt tttcagccaa ttgcaaacca
      661 tattctgaca atttagaacg gttgtttggt ccgtgttgtc ctggtacgta gttacgacgt
      721 gccaattctt tacctgtacc tgtaagtgaa aggccaaggc gacgagcttg tttccaagat
      781 ggtcctgtat aacgtgacat atgaatgtcc tcctgatata aataatattt cggtggaaat
      841 agtcacttag aaagccctga ttcgtgcaga tgcccttcgc ctaaacagcc aaggttactt
      901 gtcataagac acctgttgac gagcttcatg ctttcctgct gatatttcac acaaaatcca
      961 ttttaccatg aatagctgga tttgtaaagg ggttttaggc tttattttca ctaccagaga
     1021 gattgagaac gagggtaaag gtacttccta gaccgtactg gctgctgact gtgatttccc
     1081 cacccaattg atgggccaat tcacgcgcaa tcgcaagtcc taatccatga ccacctgtct
     1141 tcatgttacg cgaagtttcg acacgataaa ggcgtttgaa aatattttcc aaatcctctg
     1201 gggcaatgcc ctgcccttca tcggtcacac tgattgaaag ctggcccttc tccagcttag
     1261 tcaccacttc cagcttggtt cctggagcag aatatttaaa agcgttatcg accagattca
     1321 ccaagatacg agaaagctta gcataatctc cctcaatccg ggcagactct gggattacct
     1381 gcaagtggac atctcttctc tcctgctcaa tcaaaaactg aaattcactc atgcactcaa
     1441 ttaagagctt gtccagaaaa atactgtctt tactggtagt ttccacctga tttctagctg
     1501 tgtttagggt caaaaaattc aactcctcaa ccagtttatt gagcctctcc gtctggcgtc
     1561 caatggttgc tagataatga gcttgctccg actccttgat aatcccatcc aaaatccctt
     1621 ctaccgtcgc ttggatcgaa gtgatagggg tcttaatatc atgcgacaac tgagcaatca
     1681 tcaagccctt ttctcgttcg ctttcttcca aggaatcaaa gcttacctgc aaatcatggg
     1741 acatctcatt aaaagtttgc cctaattgct gaaattctac aggaccttga acctccaaat
     1801 ttgaaggaaa atccttggcc gctacccgct tggcatgctc cttgagtttg cccaacgacg
     1861 taaagactgg caataggaga aagagactaa tcccagcacc gacaaggctg gcaacgatgg
     1921 tcatcccaag caaaaagtaa atctcgcctt tcgcaatcag cattttttga acagcccaaa
     1981 aaacaaccaa aatggttaag agggttgaaa taatatatcc aaccaaaata taacttttta
     2041 gtttcatgtt tgtcctctcg gtttctctat cttatatccc aacccccaaa ctgtcttaat
     2101 agtgggagtt tggtcactac tatattttgc cagctcctgt cgaagagcat ggatatgcac
     2161 attcaaggta ttggtgtcat ccacgtagtc ttctttccag atcttttcat agaggtctgt
     2221 cttggagaaa actcgctctg gattgctagc taaaatccac agcaattcaa atgatttaac
     2281 agttaaatcc agcatttctt ctcctatttg aacttcatga ctactatgat tcatttttag
     2341 attgccaagg gaaatcagct ctgtttcgcc cccacgatga aggcggcgca aaatattgtg
     2401 gacacgcaaa accagctcac gtgggctaaa aggcttagca ataaaatcat ctgctcccaa
     2461 gctcaggccg taaatcttgt cctgttcact ggtcttagca gtaataaata ggaaaggctg
     2521 ctctggtgat aagtattgaa cctcactgat taaatcataa ccatccatcc gaggcatcat
     2581 gacatctgtg ataatcaaat caatcggttt tttcttgaac agctctagcg cttccagtcc
     2641 atcatgggct accaagacct gataacctgc ctgaattaag tatctctgat gaatatctgt
     2701 gatttctacc tcgtcgtcaa cgagtaaaat tgtctttccc atctgtctct cctttgataa
     2761 aaacagtgct atactgcttt aagtataaca ctatttttat tgttttacga tgattttaat
     2821 ctgctattga aagaaagtcc tgattgctga ttgagttgtt aaactaatct tagtcagccc
     2881 actatccatc atttatttcc ttagctgatt agttttcttc ttttttgttt ttcaaaccta
     2941 gaccaccgag taaacctgca agcgcaagcc caaggaaacc aatacttgcc attgatgttt
     3001 gagtctcacc agtatttggt agcatagctt tatcctctga catcatcgta tcagacatct
     3061 tgttagcaga agcagccatg ttttcacctg ccatcgtgtt ggtagaactt gtcatggtgt
     3121 cagcaggcac gctatctgta gtacctggag catgattgtg attcatcgga gtcacgctag
     3181 aaccagagtt agaaggtgat aatgaaccat ttgctgtgtc tgatgtttct ttaacattta
     3241 t
//
LOCUS       DAVLHC010000098         3188 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.099, whole genome shotgun sequence.
ACCESSION   DAVLHC010000098 DAVLHC010000000
VERSION     DAVLHC010000098.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3188)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3188)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3188
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.099"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            1..732
                     /locus_tag="VXE25_002098"
     CDS             1..732
                     /locus_tag="VXE25_002098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000934015.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772486.1"
                     /translation="MLNQDLFDSLEAQKIVDTLMKGQKDYVDERLEKRETMIVSNGYA
                     WTRPNHIDTAFASADLFEYKLQLAGQTWGYLEFETNTEKYGKVLLIIKGKKRLTNQFP
                     LVQKNKSGYLFEYAQMNTLYLNQHSSYKNDENSHSFPIQMELVSDEMIQEIEQATKNS
                     NIEKFMILTYEADSENNIISVDVVMPDARTGQLHLIQDLSEYIQSSSYHFEEAKYQDI
                     PNFSELSETEDFEIIPRIEKQEGQK"
     gene            747..1898
                     /locus_tag="VXE25_002099"
     CDS             747..1898
                     /locus_tag="VXE25_002099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE family transcriptional regulator"
                     /protein_id="HEV0772487.1"
                     /translation="MFNGRVLKELRLLNGLSRAELAQRINLTEQAIWQFESNETKPKL
                     STKMHLANQFHVDLTYFEQEEESIRFDSSVIAFRNADLATRKTIDIQTMYLHKVDSLI
                     DYFESFVIIPNIIIHDLSNVVSESYHKGESIEELALYAREKLGISKDNHDLLYKLERS
                     GIYIVERLINGQADAYSAWSKLGRPYIVLGTNKSSVRRNFDLAHELGHILLHKYKDMN
                     EDGDRLEQEANYFASCFLLPKEEFLVKFEERVGKRVSNPDSYILLKSDLNVSIQALEY
                     RAFKLGLLTPKQHSYFYRQIAQKGYKMIEPLDDQIFVKKPSKVKSILDVVLSNHLVSL
                     ATIMSKQSIRLQFISEIFSVEMKFFDQYQEDRRTDRFDNIIPLYKRNNL"
     gene            complement(1950..2609)
                     /locus_tag="VXE25_002100"
     CDS             complement(1950..2609)
                     /locus_tag="VXE25_002100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000564993.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin peptidase"
                     /protein_id="HEV0772488.1"
                     /translation="MIDFYFFLVGSILASFLGLVIDRFPEKSIISSASHCDSCQTRLR
                     PLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLGLLFLLYSWELLSLGQVVLITAG
                     LTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
                     FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLL
                     V"
     gene            2679..3125
                     /locus_tag="VXE25_002101"
     CDS             2679..3125
                     /locus_tag="VXE25_002101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000155432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0772489.1"
                     /translation="MTIRFEEKVSIENAQFVCQWSNSLGKSFQEQWMGPRIPFLLTLQ
                     ALEGVFSIFDEQEFVGLIQKIRLEDSNLHIGRFFINPQKQEQDLGSQALRKFVSLAFE
                     NEDIDSISLNVFEANQRAQNLYQKEGFEIVQMVEAPVRKYSRLKLE"
BASE COUNT         1159 a          480 c          653 g          896 t
ORIGIN      
        1 atgttgaatc aggatctctt tgattcgctt gaggcacaaa aaattgtaga tactttgatg
       61 aaagggcaaa aagattatgt agatgaacgt ctagaaaaaa gagagacaat gatagtgtcg
      121 aatggttatg catggacgcg acctaatcat attgatactg catttgcatc agcagatttg
      181 tttgagtata aattacaatt agcaggacag acttggggat atttagaatt tgaaacaaat
      241 acagaaaaat atgggaaagt attgttaatt ataaagggta agaagcgact tacgaaccaa
      301 tttcctttgg tacaaaaaaa taagagtggc tacttatttg aatatgctca gatgaataca
      361 ctttatctta atcaacattc ttcctacaaa aatgatgaaa atagtcattc ctttccaatt
      421 cagatggagt tagtttctga tgaaatgatt caagaaattg aacaagctac taaaaattcg
      481 aatatcgaaa aatttatgat tttaacttat gaggcggact cagaaaacaa tattatatct
      541 gtagatgttg ttatgcctga tgcacgaact ggtcagttac acttgattca agatttgtct
      601 gagtatattc aatcaagttc gtaccatttc gaagaagcta aatatcaaga tattcctaat
      661 ttttcagaat tatcggaaac agaagatttt gaaattattc caagaataga aaaacaagaa
      721 ggtcaaaagt agtaaggagt atgtaaatgt ttaatggtcg ggtattgaaa gaattacggc
      781 tgttaaatgg tttaagtaga gcagaattag ctcagagaat taatttaacg gaacaagcca
      841 tttggcagtt tgagtccaac gaaacgaaac ctaaattatc aaccaaaatg catttggcca
      901 accaatttca tgttgattta acttattttg aacaggaaga agagagcatt cgatttgatt
      961 cttctgtaat tgcctttaga aatgcagacc tagcaacacg gaaaacaata gatattcaaa
     1021 ctatgtattt acataaggta gatagtttga ttgattattt tgaaagtttt gtaattatac
     1081 ctaatattat aattcatgac ctaagtaatg tagtgagtga atcttatcat aagggagaat
     1141 ccattgagga attggctctt tatgccaggg aaaaattagg tatttcaaaa gataatcatg
     1201 atttgcttta taaattagaa cgttcaggca tctatatcgt ggaacgatta attaatggcc
     1261 aagctgatgc ttatagcgca tggtcaaaat tgggaagacc ttatattgtg ttgggaacga
     1321 ataaatcatc tgtacgtcga aattttgact tagctcatga gctaggacat attcttttac
     1381 ataaatataa agatatgaat gaagatggcg atcgtttgga gcaagaagca aattattttg
     1441 catcatgttt tttattgcca aaagaagagt ttttagtcaa atttgaagag agggttggca
     1501 agcgtgtcag caatcctgat agttatattt tattgaagtc ggatttgaat gtttcgatac
     1561 aggctttaga gtatcgagct tttaagttag gattattgac tccaaagcaa cattcttact
     1621 tttatcgtca aattgcgcaa aaaggttaca aaatgattga acctttggat gatcaaattt
     1681 ttgttaaaaa accaagcaaa gtaaagagta ttctggacgt cgttttgagt aatcatctag
     1741 tcagtctagc gactataatg tctaaacaaa gtattcgttt acagtttata agcgaaatat
     1801 tttcagtcga aatgaaattt tttgatcagt atcaagaaga tagaagaaca gatcgatttg
     1861 ataacatcat ccctttgtac aaaagaaata atttataatt taactgtgaa ataatttcat
     1921 gaaggacata tggcagaaat tggattttat cagacaagca gtagcttacc aaaaataatc
     1981 aaacaagtag caagtaagag gaaaggcacg aaaggaagtc tttccttttt cttttgcagg
     2041 ataaaggcca ggatacccgt cgcagaagca aactgaatca agatcagtaa ctccgttacg
     2101 ctaaagacga gagcacaaga agctaaaaag aggaaatctc ctgcgcccat gcggatatcg
     2161 ataaaatgag ccaaaattcc aagagcaagg aaggagacca tgaccagatt ccagccagag
     2221 gaagctatta ggattaggtg gaaagtcatc cagaccagta agggatattc ctgatggtga
     2281 aagtcgtaga tacccaaggt caaaccagcg gtgattagga cgacttgccc caaggaaagc
     2341 aattcccaag agtaaagcag aaagaggagt cctaagacta attcaaagag ggcataccag
     2401 acaggatagc gaactttgca gtagcgacag cgaaagcgat tgaagacctg tgagagaatc
     2461 ggaatcaaat ctaagggacg caagcgagtc tgacaggaat cgcagtgact ggctgaactg
     2521 ataatggatt tctctggaaa acggtcaatg accaaaccaa gaaaggaagc gagaatgctc
     2581 ccgacgagaa aaaaataaaa atcaatcata cttatctatt cgtaaaaaat gggagaaata
     2641 gtataatgga gaaacataga taagatggtg aggaaaagat gacaattcgt tttgaagaaa
     2701 aggtgagtat agaaaacgct caatttgtat gccagtggtc caactcccta ggcaaatcct
     2761 ttcaagaaca atggatggga ccaaggattc cttttctact gacccttcaa gccttggaag
     2821 gagtcttttc aatctttgat gaacaagagt ttgtgggact tatccagaaa atcaggctag
     2881 aagacagcaa tcttcatatc gggagatttt ttatcaaccc ccagaaacag gagcaagact
     2941 taggtagcca ggctttaagg aaatttgtta gtttggcctt tgaaaatgaa gatatagata
     3001 gtatttctct aaatgtcttc gaggcaaatc aaagagctca gaatctttac caaaaagaag
     3061 gatttgaaat cgttcaaatg gttgaagcac ctgtacgaaa atatagtaga ttgaaactag
     3121 aatagtacac ctctacttct aaaacattgt tagaaatcga tttgactgtc ccgatcgatt
     3181 cgtcctgt
//
LOCUS       DAVLHC010000099         3185 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.100, whole genome shotgun sequence.
ACCESSION   DAVLHC010000099 DAVLHC010000000
VERSION     DAVLHC010000099.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3185)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3185)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3185
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.100"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(223..519)
                     /locus_tag="VXE25_002102"
     CDS             complement(223..519)
                     /locus_tag="VXE25_002102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000837727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uberolysin/carnocyclin family circular
                     bacteriocin"
                     /protein_id="HEV0772490.1"
                     /translation="MKSKRMEFHNKFLIVSAMLAVISWLSLGVVSFPMLAGTLGISTK
                     AAATVVNLISAYSTVTAVISIVGAITGVGSIGSGIAATVLYILKKKGAAKAALW"
     gene            complement(1062..1955)
                     /locus_tag="VXE25_002103"
     CDS             complement(1062..1955)
                     /locus_tag="VXE25_002103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000343891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEV0772491.1"
                     /translation="MDELKREIGYKIKTIRRSCGKTQIDICGDESELTIRQLARIENG
                     QALATLPKLLLIADKLGVSLQNIVDVKVIEIPKGFLKLKDELIHSQTYADKGRIERKE
                     AILEEIYENYYENLPEEEQLIVDVTQARFDIYGSSDVTYGLGLVEEYFQQLLKKKYFS
                     VNDLLIIELYFFCCAMGLEDKEHFEELAQKVLLCSEYEDKASLVQMEKVLLSLFIQIQ
                     TEDSLIYIQTFEKIIAKTRHVFYRPHLFLLKAKYALFVDKNILEAESFYEKAISLAEL
                     LDDQVLVQRILAEKQIDFPTT"
     gene            complement(2709..2939)
                     /gene="blpU"
                     /locus_tag="VXE25_002104"
     CDS             complement(2709..2939)
                     /gene="blpU"
                     /locus_tag="VXE25_002104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-like peptide BlpU"
                     /protein_id="HEV0772492.1"
                     /translation="MNTKTMSQFEIMDTEMLACVEGGGCNWGDFAKAGVGGGAARGLQ
                     LGIKTRTWQGAATGAVGGAILGGVAYAATCWW"
BASE COUNT         1079 a          638 c          350 g         1118 t
ORIGIN      
        1 atttattttt ttactttgga taggcagttt catattataa cgattcaaag tagcgtaatc
       61 tactaccaaa aaaagtaaaa ataatttccc ttgaaaagga agatagcttt taaaatagat
      121 tgacaaactt atgataacaa aaaacaaaag ggttatccca ataaaattaa gataacctaa
      181 aatactttca cattcttttt tagaaagtat tttcatctag ttctaccata gagctgcttt
      241 agcagcacct ttctttttca atatataaag aactgttgct gcaatacccg aaccaataga
      301 acctactcct gtgattgcac ctacaattga aattactgct gtaactgtac tataagcact
      361 aatcaaattg actacagtag cagcagcttt tgtcgaaatt cctaatgtcc cagccaacat
      421 aggaaaagaa acaacaccta agcttaacca actaatgact gctaacattg ctgaaacaat
      481 aagaaattta ttatgaaatt ccattctttt agatttcatt ttagtgtact ccttttgtat
      541 attatgtatg ttttattgag agttaattcg cacatgttgt attcctaact ctcttcaaat
      601 gttcgtctat attttatact acttttatta acatatctat aataaataaa ttactactac
      661 attttcctag attatcaaat tacttttata tcactaagac tcaataaaag ataatgtcta
      721 tttaactttt atacgattac tacctccttt ttagtttaca cttcctacat cataaataaa
      781 catactaaac cctcacaatc tccaaataac tcttctatat cattgaaaat tgagtttcat
      841 cctctatact aatgtaggaa acctattaaa acattccttt aatccaatat aagaatacct
      901 tgttccatta atctctaccc gatattatag atagaaccaa attcctatac ttaaaaggac
      961 aaataacgtt ccaaccataa taaacctcct ttctttttga gaacgttttc tttataggtt
     1021 tagtgtagca aaaacatgaa aaaaacaaca tgacttagaa gtcaggttgt tgggaaatct
     1081 atctgttttt ctgctaaaat tctctgaact aatacctgat cgtctagcaa ttctgctaga
     1141 gaaatcgcct tttcatagaa actttctgcc tctaaaatat tcttgtctac aaataaagca
     1201 tattttgcct ttagcaaaaa tagatgaggt cggtaaaaaa catgtcttgt tttagcaata
     1261 attttctcaa atgtttgaat atatatcaga ctatcttctg tctgaatttg gataaatagg
     1321 ctcagaagaa ctttttccat ttgaactagg ctagccttat cttcatattc tgaacatagc
     1381 aatacttttt gagctaactc ctcaaaatgt tctttatctt ctaatcccat agcacaacaa
     1441 aagaaataca attcaataat caacaaatca tttacagaaa aatatttctt ttttaataac
     1501 tgctggaaat attcttccac taaccctaaa ccgtaggtca catctgaact accataaata
     1561 tcaaaacgag cttgtgtcac atccacaatt aactgctctt cctcaggcaa attctcataa
     1621 tagttttcat atatttcctc aagtatagct tcttttcgtt cgattcttcc cttatcagcg
     1681 taggtttgag aatgaatcag ctcatctttg agttttagga atccttttgg aatctctata
     1741 accttaacat ccacaatatt ctgtaatgat actccaagtt tatccgcaat caataataat
     1801 ttaggaagtg ttgctaaagc ttgcccattt tcaatacgtg ctagctgacg aatcgtcaac
     1861 tctgattcat caccacaaat atctatctga gtttttccac aagatcgcct aatagttttg
     1921 attttataac caatttcacg tttcaactca tccatagtaa tactccttaa gttgattaca
     1981 aagatttctt tttcttccta attcttttgt caatcatata taaaacgata agcgaaaaca
     2041 gcggtagaac aatataactc ttttcactca ttatcagctg aaatcccagg gttgctagta
     2101 tcttaaagat gaaaatattc atcaaaaata gaaaaacaaa tactaaaaaa tattttaaaa
     2161 ccttcttcat ttcttttctt caactttcct aatttctaca cctattttat cgaaaatata
     2221 tataaaactc caaataaaca cttcgactgc actttttttg gcaaaaaata gacagaacaa
     2281 acatcctacc tactaaaaat atgatatgaa aggaaaatga ttttttactg acaccctagg
     2341 caagcttggg acaaataaat cattgatagc aacatttacg acatcctatt taaagttcct
     2401 tcaatttcta atgtccccgc tatttctaag ccacctctgg tatgatctat tcctagtcag
     2461 aatagataac accgttctaa attacgattc atagttactc cttttttgac tcgttactat
     2521 aagactccta tttacatgcg caaaataatt ttgattcaga ttcatcattt atagttttga
     2581 ttatttttta acagattttt ctgttttctt ctccgaagac tttaaaaatt tttttctaat
     2641 taaatcatcc atataaggac caaatatacc aactactaaa ccaataataa aacttttaaa
     2701 atccataatt accaccaaca tgtcgctgca taggccacac ctccaagtat agctcctccc
     2761 acagcaccag ttgctgcacc ttgccatgtt cttgttttaa ttcctagctg aagacctcgt
     2821 gctgctcctc ctccaacacc tgctttggca aaatctcccc aattgcatcc gccaccttca
     2881 acgcaagcaa gcatctcagt atccataatt tcaaattgtg acatcgtttt tgtattcata
     2941 acgaatacct cttttttatt tttaatattt gtcttgttac aaacttgaca agtttagtat
     3001 aacagtatct attaattttt ttcatccaaa tcttgaattg gcatcgaaac gtcttgaatt
     3061 agcttttttg tttcaaaatc atctctattt ttaaaaaaga tgttttctaa tcactttttt
     3121 actattagac ttcctgcaaa actagaatcc tagttcatga ttgataatac cagcaatcaa
     3181 attca
//
LOCUS       DAVLHC010000100         3136 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.101, whole genome shotgun sequence.
ACCESSION   DAVLHC010000100 DAVLHC010000000
VERSION     DAVLHC010000100.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3136)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3136)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3136
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.101"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            131..1354
                     /gene="dcm"
                     /locus_tag="VXE25_002105"
     CDS             131..1354
                     /gene="dcm"
                     /locus_tag="VXE25_002105"
                     /EC_number="2.1.1.37"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000638391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA (cytosine-5-)-methyltransferase"
                     /protein_id="HEV0772493.1"
                     /translation="MIWVLDLFAGIGGFRMGMEAQGHECLGFCEIDKFARKSYKSIFQ
                     TEGEIEFHDIRDVSDDEFKKLRGKVDVICGGFPCQAFSIAGRRLGFEDTRGTLFFEIA
                     RAAKQIQPRFLFLENVKGLLNHDKGRTFTTILTTLDELGFDVEWQVLNSKDFGVPKNR
                     ERVFIIGHSRKKGTRLLFPFRREGQATNSETLKALGNLNPSRSGMSGKVYYSEGLAPT
                     LVRGKGEGFKVAIPCMTPDRLDKRQNGRRFKENQEPMFTLNTQDRYGIVVVGDLPTSF
                     KETGRVYGSEGLSPTLTTMQGGDKIPKILIPEPIQFLKVREATKKGYAQAEIGDSINL
                     ERPSSQYRRGRVGKGIANTLTTSGQMGVVVASYEGEDKQVYQVAGVLIDGQFYRLRIR
                     RITPKECFRLHGFPD"
     gene            1382..1492
                     /locus_tag="VXE25_002106"
     CDS             1382..1492
                     /locus_tag="VXE25_002106"
                     /inference="COORDINATES: protein motif:HMM:NF012372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA cytosine methyltransferase"
                     /protein_id="HEV0772494.1"
                     /translation="MNSQLYKQVGNSVTVPVIAAIAKKLKEIEEKDKSIK"
     gene            1476..1925
                     /locus_tag="VXE25_002107"
                     /pseudo
     CDS             1476..1925
                     /locus_tag="VXE25_002107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000645893.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            1918..2298
                     /locus_tag="VXE25_002108"
     CDS             1918..2298
                     /locus_tag="VXE25_002108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arsenate reductase family protein"
                     /protein_id="HEV0772495.1"
                     /translation="MIDLYLSKNSQRNQLLLDFFQNYGIEVSCHSVSEMTKDKLIEMM
                     SYSSDCFEFLSPNLLRFKNRDNLRLTDFVEIILKNPELTIGLPFVVSNKRVYPSLNLE
                     EARALLPRDTKQLIYMAQTHYLSN"
     gene            2311..2544
                     /locus_tag="VXE25_002109"
     CDS             2311..2544
                     /locus_tag="VXE25_002109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000840775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HEV0772496.1"
                     /translation="MAERFWENLSIILAERNISWIELTRKMFAGEFHYPSELNRLYQK
                     IRHYKMEQRMPQSPWVERIVQILDLDYEDLFRR"
     gene            2547..3134
                     /locus_tag="VXE25_002110"
     CDS             2547..3134
                     /locus_tag="VXE25_002110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000821297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEV0772497.1"
                     /translation="MKRIIPVYIFQQVNVLLVSLYLLKFLCIGELTILQVLYGASLFS
                     FLWMYGQRKQVVKVNMKTRMKCLGIGLASLLIISLCFSLIHAQGSTNQTNLIGLQHQV
                     PWFSFLLFLINASMVEEFLYREILWNLVRKLDIRVALTSVLFALVHHPGTILAWCLYV
                     SLGMFLGMVRYKSDLWGSMGLHLVWNFLVYSLLLF"
BASE COUNT         1029 a          463 c          680 g          964 t
ORIGIN      
        1 cttttgagga aatctagcga ggaaaaacga tactggaaca gcagaaagta aaactgacct
       61 catgaggagg aagaaagtgg ctcatgaggt caggggtttt gtaagttaca tctagttgag
      121 agaggtatga atgatttggg ttttagattt atttgctggg ataggaggct ttaggatggg
      181 aatggaagct caagggcatg agtgcttggg attttgtgag attgataaat ttgctaggaa
      241 atcttataag tccatttttc aaacggaagg agaaatagaa tttcatgaca tacgagatgt
      301 ttcagatgac gaatttaaaa aacttagagg gaaagtcgat gtcatctgtg ggggattccc
      361 ttgtcaagca ttttcaatcg caggaagacg attgggattt gaagatacta gaggaacttt
      421 gttctttgaa attgctcggg cggccaaaca aatccaacca cgttttcttt ttcttgaaaa
      481 tgttaaaggc ctactcaatc acgataaggg acggacgttc accacaatac ttaccacact
      541 tgatgagttg gggtttgatg ttgagtggca ggtgcttaac agtaaggatt ttggcgttcc
      601 caaaaacaga gagagggtgt ttattatcgg acattctaga aagaaaggta ccagactctt
      661 atttcctttc agacgagaag gtcaagcaac taactctgag actttgaaag cactaggaaa
      721 tttgaatcca tcaagaagtg gaatgagcgg taaagtctat tattcagaag gtcttgcgcc
      781 aaccttagtt cgtggtaaag gagaaggatt taaagttgcg attccttgta tgacaccaga
      841 tagattagac aagagacaaa atgggagacg ctttaaggaa aatcaagagc cgatgtttac
      901 tttaaatact caggatcgtt atggcattgt cgttgttgga gatttaccga ctagctttaa
      961 ggagacaggt cgtgtctatg gaagtgaggg cttatctcca acactgacta cgatgcaagg
     1021 aggagataaa atccccaaaa tactaattcc agaaccaatc caatttctaa aagtacggga
     1081 agcaacgaaa aaaggatatg ctcaagcaga gattggggat tcaatcaatt tagaaagacc
     1141 aagttctcag tatcgtcgtg gtagagttgg aaaaggtata gctaatacgt taacaactag
     1201 tggtcaaatg ggagtagtag tggctagcta tgaaggagaa gataaacaag tttaccaagt
     1261 agctggtgtt ttaatagatg gacaatttta ccgtttgaga atacgacgaa tcactcctaa
     1321 agagtgtttt cgattgcatg gctttcctga ttaggctttt gaagctgcta gaaaagtctc
     1381 tattaatagt cagctctata aacaagttgg taatagtgta accgttcctg tgattgccgc
     1441 aatcgcaaag aaattaaaag aaatagagga aaaagataaa agcattaaat aaagaatcaa
     1501 tactagattg tgatgaatta gaaacagaat tacatgatgc agaaatcaaa cagctggatg
     1561 aacaaatatt tttgatgccc aattatccat gtgagtttga ggtaacattt ttagatgatt
     1621 accataaaaa acataattac ccactatttt atgaatccta tcttcaaaac gttatggaat
     1681 tccttgaaag tcaggatata aagaacggag ttaatgcctt tgtagatgat aatcagaatc
     1741 ttgtttttgt tttatattga caagactatc gagccgaggg aaaagagggg atacttacaa
     1801 cccaagtaac tgtaaaagct tatgatgaag acaagaaatc gattaacttc tcaaagttgt
     1861 tagattcctt aatcgtctca gaatatcaaa tggaagcaaa tttgttggag gtctcccatg
     1921 attgatctct atctaagtaa aaatagccaa agaaatcaac ttcttttaga cttcttccaa
     1981 aactatggca ttgaggtatc ttgtcattca gtttctgaaa tgacaaagga caaattaatt
     2041 gagatgatga gctattcttc agattgtttt gagtttttat ctcccaattt attacgattt
     2101 aagaaccgtg acaatctaag attaacggat ttcgttgaga taattttaaa aaatcctgaa
     2161 ctaaccatcg gacttccttt tgtggtttca aataagcggg tttatccaag tctgaatttg
     2221 gaagaggcta gagctctatt gccaagagat acgaaacaat tgatttacat ggcacaaaca
     2281 cattatttat ctaactaaag gagaagtaat atggctgaac gattttggga gaacttgtcc
     2341 attattttgg ctgaaagaaa tatcagctgg attgagttaa ccagaaaaat gtttgcggga
     2401 gagtttcact atccaagtga attgaatcgt ttatatcaaa agattcgcca ctacaagatg
     2461 gaacaacgaa tgcctcaaag tccatgggta gaaaggattg tgcagatatt agatttagat
     2521 tatgaagatt tatttcggag gtaactatga aaagaataat tccagtttat atattccaac
     2581 aagtaaatgt cctattggta tctctatact tattgaaatt tctttgtatc ggtgagttaa
     2641 ctatactaca ggttctctat ggtgcgtctc ttttttcttt tttatggatg tatggtcaac
     2701 gaaaacaagt ggtcaaggtc aatatgaaaa ctaggatgaa atgccttggt attggactag
     2761 ctagtctact gattataagt ctatgtttta gcctgattca tgctcaagga agcacgaatc
     2821 aaacaaattt aattggcctt caacatcaag ttccttggtt ttcattttta ttgttcttaa
     2881 tcaatgcgag tatggttgaa gaatttctgt atcgtgaaat tttatggaac ttggttagaa
     2941 aattagatat tcgagttgct ttgacaagtg ttttatttgc cttagtacat catccaggaa
     3001 ccattctagc ttggtgtctg tacgtttcac ttggaatgtt tttaggtatg gtgcgctata
     3061 aatctgactt atggggaagt atggggttac atttggtgtg gaacttttta gtttatagtt
     3121 tgctgctttt ttaaaa
//
LOCUS       DAVLHC010000101         3060 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.102, whole genome shotgun sequence.
ACCESSION   DAVLHC010000101 DAVLHC010000000
VERSION     DAVLHC010000101.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3060)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3060)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3060
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.102"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..822
                     /locus_tag="VXE25_002111"
     CDS             <1..822
                     /locus_tag="VXE25_002111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000570495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide synthesis protein"
                     /protein_id="HEV0772498.1"
                     /translation="IIKNQNIAFQQDTDIAYRKLKKKFRHISLTGDELKYKMEFSNKV
                     WICWFQGEEHAPELIKTCIQSMRNQLQGREIIVLTEKNISDYTEIPDYIIEKYKKGWI
                     SRAHYSDILRIDLLCRHGGLWVDATVLNTGGDFSNLEVPLFVYKSLNLSRKDSQAIVA
                     SSWLISSYSNHPILLYTRKLLWAYWRRKNSLCNYFLFHICFTIATERYPIEWSAVPTF
                     NNHSPHILHFELNEQFSEKRWEQLKHISAFHKLNHHIDYSSGVNTFYKFIVSSKV"
     gene            827..2290
                     /locus_tag="VXE25_002112"
     CDS             827..2290
                     /locus_tag="VXE25_002112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000066237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="HEV0772499.1"
                     /translation="MSNKISKNLAYNMGYQLIGIAAPLITSPYLSRILGAENLGIHSF
                     TMSVALYFMMFMLLGIANYGNRTIATVKREGKDILSKTFWSIYSIQLIMSILVTIAYL
                     AYLYLGAVHYKVIAILQLFLLLSNAVDITWFFYGLENFKQIVFRNTLVKLLGLFLIFL
                     CVRQGTDLWKYTFINGSVTLVGQLLLWGQLKGILTWKKIQLKELLPHIKPILILFIPV
                     LAISIFTNMDKYMLGLMVDVKQVGFYDNAGRIIEIPKALIAALGAVMLPRTSYLLAEG
                     QKEKSKYYIEVTILYVMIISSVLMFGLISVSDIFSIIFWGEEFLESGRLISAMSPAFV
                     FSVLGNIIRTQYLIPRAKDKDYVVSLIAGAVVNLVLNYFFIKPFGAMGATISTVLAEF
                     VLSGMQFWSVRRDLDLKRYLKNGLIFYLFGLIMHLIIIALKTQLPYNIMSLILLIVLG
                     GIVYVIFCCCYILMSRNLHFKLLKEKIIRKVVHKNTL"
     gene            2677..>3060
                     /locus_tag="VXE25_002113"
     CDS             2677..>3060
                     /locus_tag="VXE25_002113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000256585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyltransferase family protein"
                     /protein_id="HEV0772500.1"
                     /translation="MVTKDKGLTYNSTLHAIKVLACFSVVAIHIWLPGKIGAFYQIIA
                     RFAVPMFFLISGFYSYNISKNKIQNRIKKIFRLILRSTFFYVIIFVWMFWREGNMQFI
                     FQNFNLTNIIRFVIFNRISDLIGYLA"
BASE COUNT         1030 a          352 c          552 g         1126 t
ORIGIN      
        1 attataaaaa atcaaaatat agcttttcaa caagataccg atatagcata tagaaaacta
       61 aagaagaagt ttagacatat ttcgttgact ggagatgagc ttaaatataa aatggagttt
      121 tcaaataaag tttggatttg ttggtttcag ggagaagagc atgccccaga gttaattaaa
      181 acatgtattc aatcaatgag gaatcaactt caaggaagag aaatcattgt gttgacagaa
      241 aaaaatataa gtgattatac agagattcca gactatatta ttgaaaaata caaaaaagga
      301 tggatttctc gtgcgcatta ctctgatatc cttaggatag atcttctatg tcgccatgga
      361 ggattatggg tagatgcaac agtgttgaat acaggaggag atttctcaaa tcttgaggta
      421 ccactttttg tatataaatc tttgaattta tcaagaaaag attcacaagc tattgtagca
      481 tcaagttggt taatttcgtc atatagtaat catcctatat tactctatac gagaaaactc
      541 ctatgggcct actggcgaag aaaaaatagt ttatgtaatt attttttgtt ccatatatgt
      601 tttacaatag ctacagagcg gtacccaatc gaatggtctg ctgtccctac ttttaataat
      661 cattctcctc atatacttca ttttgagttg aatgaacaat tttcggaaaa acggtgggaa
      721 caactgaagc atatttcggc gtttcataaa ttaaatcatc atatagatta ttctagcggt
      781 gttaacactt tttataagtt catagtatct tcgaaagttt agaaaaatga gtaataaaat
      841 tagtaaaaat ttagcctaca atatggggta tcagttaatt ggtattgcag ctcccttgat
      901 aacttctcct tatttatcac ggatattagg tgctgaaaat ttaggtattc attcttttac
      961 tatgtcggtt gcactttact ttatgatgtt tatgcttctt ggaattgcaa attacggaaa
     1021 tagaacaatt gcgactgtta aacgagaagg aaaggatatt ctatcaaaaa cgttttggag
     1081 tatctactct atccagttga taatgtctat tctggtaact atagcttatc ttgcttatct
     1141 atatttgggg gcagtacatt acaaagttat tgcaatatta caactctttt tattgttatc
     1201 aaatgctgtt gatattactt ggtttttcta tggattagaa aattttaagc aaatcgtttt
     1261 taggaataca ttagtcaaac ttttaggatt atttttaatt tttttatgtg tgcgtcaagg
     1321 cacagattta tggaaataca catttataaa cggatcagta actttagttg gccaactttt
     1381 actatgggga caattaaaag gaatattaac ttggaaaaaa attcaattaa aggaattact
     1441 acctcatatc aagccaattt taattctttt tattcctgta ctagccatta gtatttttac
     1501 taatatggat aaatatatgc ttggtttaat ggttgatgta aagcaggttg gattttatga
     1561 caatgcaggt agaattattg aaattcctaa agctttgatt gcagctttag gggccgttat
     1621 gttaccaaga acttcctatt tattagcgga aggacagaaa gaaaagagta aatactacat
     1681 agaggtaaca attttatacg tgatgattat ttctagtgta ttgatgtttg ggctaatatc
     1741 ggtatctgat attttttcca ttatattttg gggagaagaa tttcttgaat caggtagatt
     1801 gatttctgct atgtctccgg cttttgtctt ctctgtatta ggaaatatca ttaggactca
     1861 gtatttgatt cctagagcta aggataaaga ttatgtagtg tctctaattg cgggggctgt
     1921 tgttaatcta gtgctaaact atttttttat aaaacctttt ggtgctatgg gagcaacaat
     1981 tagtacagtt ttggcagaat ttgtattgtc tggaatgcag ttttggtcag taagaagaga
     2041 cttagattta aaaagatatt tgaaaaacgg tttgatattc tacctatttg gtctgattat
     2101 gcacctcatt attatagcac tcaaaactca gttaccatac aatataatga gtcttatttt
     2161 actaatagtt ttgggtggaa tagtatatgt tattttttgt tgttgctata ttttaatgtc
     2221 aagaaattta cattttaagt tattgaagga aaagattata cgaaaggttg tacataaaaa
     2281 tacattataa aatattagtt tatcttattt agttggatac tattaaataa acgaaagtat
     2341 ttgaaacttt ggtaattgag attatagaga ttatagagat aaactaagct atattatagc
     2401 ttcattatta aagtaagaat atcggtgcag tgtagttaac gaataatgtg agtactcatt
     2461 tcttagatgg agctaggggt cattataagg gattgatatg acattttgag taagttacag
     2521 ctagagttta ggtttgatta tatcagatat ttagatgatt tggaaaataa taaaataagt
     2581 taggaactat ttttttattg ttttgagtga caggtttgat tttgggaaat gtattttgtt
     2641 aaatgggaaa tgtattttgt taaataggta ggaaagatgg ttactaaaga taaaggatta
     2701 acatataata gtactttgca tgcaataaaa gtattagcat gttttagtgt tgttgctatt
     2761 catatatggc taccaggaaa aattggagcg ttttatcaaa taatagcacg atttgcagtt
     2821 ccaatgttct ttttgatttc tggcttttat tcatataata tttcaaagaa taaaatacag
     2881 aatagaatta aaaaaatatt tagattgata ttaagaagta cattttttta tgtaataata
     2941 tttgtatgga tgttttggag agaaggtaat atgcagttta tttttcaaaa ctttaattta
     3001 acaaatatta taagatttgt gatttttaat aggatttcag atttaatagg ctatctagca
//
LOCUS       DAVLHC010000102         3051 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.103, whole genome shotgun sequence.
ACCESSION   DAVLHC010000102 DAVLHC010000000
VERSION     DAVLHC010000102.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3051)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3051)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3051
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.103"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            895..1953
                     /locus_tag="VXE25_002114"
     CDS             895..1953
                     /locus_tag="VXE25_002114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001849785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772501.1"
                     /translation="MKDDQKYLLAGLYSLLVAIFYFPLIDSKGIFVSILMAVLLLYLI
                     YFIATVIHIVIIKFIRKKSFKYLVLYPFTYDGSWRFQPINLLYFPEMVRDVIPINLVQ
                     EYCQGQPYGLLKKMLKRIRLSREISLLLATIIVYFFTHRILPLSVFTFMFSYILLFVQ
                     SYLGSNTAWIGNRRLIIDDEFEKILLSKSYVKEISSARYSEYLTCEYKNLTPIILIAI
                     FENLLDSYLLQNQSEVDLDIFYKVLPLLYKEKYTMGFNYFVSLNYLLYKVGFLGIIYD
                     NEALRDLSKQYLNKNISELQDGSFEGGIQDAVASKQIVVINEFIACLNSRCVPSQYDR
                     FFYKDRPYIFSRKSPIKG"
     gene            2268..>3051
                     /locus_tag="VXE25_002115"
     CDS             2268..>3051
                     /locus_tag="VXE25_002115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001837003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772502.1"
                     /translation="MKNKRYFFDTILIILLLISTIFCVSPVFIKLDILGTPSHAILTF
                     VLAIPLFYILSQCLHTLLLLVSSIFCKLRPIYFYFIFVIIIGARKYYRILFHQLMGFS
                     PGIAVFYKESQTTKNLFKFYYFLYFTTLISYYFFFTFVYDKPLLLPLILFSIIIALVQ
                     KLYRIENQQLFLLKSKVLTILESKKNCEFNLQDYHEIWKLQSKSELPCVALSYISLIK
                     PYLSESVREQIDLLEVKRFKKINHPISLYGMLDVIKLNLYLRH"
BASE COUNT          998 a          391 c          521 g         1141 t
ORIGIN      
        1 tacagactaa ataatattaa tctgtgtaat acagtagctc ggtcattaga ttctattgaa
       61 gatataaatt aaaaatgagg ctgggaaaaa actcaatttg aaaatgaaat tgagtaaatt
      121 tttctattat ataacgcata ttatcaagat ttttgaacac ctgataatat gcacttttct
      181 tattttaaag attttttgcc tttcttcatt tcttggatga attggagaga tgacttgatt
      241 taggtgtttg acattactat agataggatt tagcagtact aatatgaact catattatag
      301 gtgtagactt aaattttgga agcaagctaa aggatatctt atctaggtaa ctaagtgcta
      361 taacaagata tattggtgga gttagtatgg caactattac taatgctctt aatattgcgg
      421 ctactgttgc tgaagtcttc tcattaggag gagccattgc atatggttta gatatcgtag
      481 acggtaaatt tgatgggtat ttatgggcgt aaaactatag ctatgaaaca tttttttgca
      541 ggaattggtg aaattcattt tttgttattt ttattatatc taagcatgtc tgctagtcca
      601 attattggac tagtgattgg atatactaaa ataaatctaa taaattctat tattatagct
      661 cttggtatga tattggcatt aattttggta ttatcaagag tgtatagaaa atatttttat
      721 agagacgatg atgactaaag tttttatcaa taatttgggc tccttgtcaa ctgtagtggg
      781 ttgaataaaa gctaacgtct ggggaagggt ttaaagcttt gctttatcaa atattgactt
      841 acagagttgc tctattgtat tgatgtattc ttagtaaata atatggtgtt ttgaatgaaa
      901 gatgatcaga aatatttatt agcgggactt tattcgcttc tagttgcaat attttatttt
      961 ccattgattg attccaaggg gatttttgta agtatattga tggcggtttt acttttatat
     1021 ttaatatact tcattgcaac agtcattcat attgtgataa ttaagtttat aagaaaaaaa
     1081 tcttttaagt atttggttct atatccattt acttacgatg ggagctggag atttcagcct
     1141 ataaacttac tctactttcc agaaatggtg agagatgtca ttccgattaa tttagttcaa
     1201 gaatattgcc aaggacaacc ttacggactg ttaaaaaaga tgctgaaaag aattcgattg
     1261 tcacgagaga tatctttact cctggctacc attatcgtct atttttttac gcatagaatt
     1321 ctacctcttt cagtatttac gttcatgttc tcttacatat tgctatttgt acaatcttat
     1381 ttgggtagca ataccgcttg gattggaaat agaagattaa taatagatga tgaatttgaa
     1441 aaaatcttgc tttcaaaaag ttatgtaaaa gaaatatcat ctgcacgata ctcagaatac
     1501 ttgacatgtg aatacaaaaa ccttacacca atcatattga tagctatttt tgaaaatttg
     1561 cttgactcct acttgcttca gaatcagagt gaggttgact tagatatttt ttataaagtt
     1621 ttacctttgc tttataaaga aaaatatact atgggattca attactttgt aagtttaaat
     1681 tatttactat ataaggttgg atttttggga atcatttacg ataatgaagc attaagagat
     1741 ttgtcaaaac aatatttaaa caaaaatatt tcggaattac aagatggttc tttcgagggc
     1801 ggtatacaag atgctgttgc ctctaaacaa atagtagtta taaatgaatt tatagcttgt
     1861 ttaaattcca gatgcgtgcc atcccaatat gatagatttt tttataaaga tagaccttat
     1921 attttttcca gaaagagtcc tattaagggg tgaaaatttg ttacatttgg attaacaagt
     1981 gtcctaggga ttagaaataa ctctagtata gctagatatt tttgagtaac tagaaatatc
     2041 attaggctac ccatatgatt gccagaaaag atggctgatg aatcttattt atactgttgc
     2101 agtaggcatt gtctaggata aataagctat cttgatgggg gagattggaa taattttagt
     2161 agaaacatta aaggattatg gacaagtagc gtaggattag gtgatgcaat gtgctaagtt
     2221 ggcttggtgt tagcagtagt attatttaac aatggaaagt agactaaatg aaaaataagc
     2281 gttatttttt tgacacaatt ttaataattt tactgcttat aagcacgata ttttgtgtca
     2341 gcccagtatt tataaaattg gacatcttag gaactccctc tcatgccatc ttaacctttg
     2401 tattggcgat accgttattc tatattttgt ctcaatgctt acatactttg ctattactag
     2461 tttcctcaat cttttgtaaa ttaagaccaa tttattttta ttttatattt gtgatcatta
     2521 taggagctag gaaatactat cgaattctct ttcaccaact aatgggattt agtccaggaa
     2581 tagcagtgtt ttataaggag agtcaaacaa ctaagaatct gtttaaattt tactacttct
     2641 tgtactttac aacactaatt tcatactatt ttttctttac ttttgtgtat gacaaaccgt
     2701 tgcttttgcc tcttatttta ttttctatta tcatagcatt agtacaaaaa ctttatagaa
     2761 ttgagaatca acaattattt ctgttaaaat caaaggtact aacaatactg gaatctaaga
     2821 agaattgtga gtttaatctt caggattatc atgaaatttg gaaattgcaa tcaaaatctg
     2881 agttgccatg cgtggcttta tcttatatca gtttaatcaa gccatatctt tcagagagtg
     2941 tgcgtgaaca aattgattta ttagaagtta agcgatttaa aaaaataaat catccaatat
     3001 cactttatgg tatgttggat gttataaaat taaatctata tttacggcat t
//
LOCUS       DAVLHC010000103         3050 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.104, whole genome shotgun sequence.
ACCESSION   DAVLHC010000103 DAVLHC010000000
VERSION     DAVLHC010000103.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3050)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3050)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3050
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.104"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(166..285)
                     /locus_tag="VXE25_002116"
     CDS             complement(166..285)
                     /locus_tag="VXE25_002116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808898.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine synthetase"
                     /protein_id="HEV0772503.1"
                     /translation="MPDIVFEIEFFHSDSLIFFYTSDDKSNSQKSQEDFSKNK"
     gene            830..2149
                     /locus_tag="VXE25_002117"
     CDS             830..2149
                     /locus_tag="VXE25_002117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000229450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HEV0772504.1"
                     /translation="MPDTWEWVRFSTLVEIVRGGSPRPIKDYLTSEVDGINWIKIGDT
                     EKGEKYINNVKEKIKKSGLNKTRFVKKGTFLLTNSMSFGRPYILNVDGAIHDGWLAIS
                     NYENSLNKDYLFYILSSNVVYSQFLSLISGAVVKNLNSDKVASILIPLPPLAEQQRII
                     EAIESALEKVDEYAESYNRLEQLDKKFPDKLKKSILQYAMQGKLVEQDPNDESVEVLL
                     EKIRAEKQKLFEEGKIKKKDLDISIVSQGDDNSYYEEVPCEIPESWEWVRLNDITSYI
                     QRGKSPKYSNIPIYPVIAQKCNQWSGFSIDLARFIDPETVHSYQKERLLRDGDLMWNS
                     TGLGTLGRLAIYHENKNPYGWAVADSHVTVIRVLSGVINCHFIYNFLSSPIVQSVIEE
                     KASGSTKQKELLTKTIKEYLIPLPPLPEQSRIVDKIEQFFAHINALI"
     gene            2206..3003
                     /gene="psrA"
                     /locus_tag="VXE25_002118"
     CDS             2206..3003
                     /gene="psrA"
                     /locus_tag="VXE25_002118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000651177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type DNA invertase PsrA"
                     /protein_id="HEV0772505.1"
                     /translation="MKDFELHLKKAGLAENTVRSYLYGVRFFLENYELKMEDLFEYKG
                     YLLDNFKPKTVNLRLQGVNKYLAFIGHDDLKLKFVKVQQKPFLEDVISHADYLFLKRS
                     LKKDGILKWHFVVWFLGATGARVSELIKLKVEHVEIGYFDIYSKGGKIRRLYIPKKLR
                     NSCLSWLESENRRSGYLFLNKFNEPITARGVAQQLKNYADKYKMNPKVIYPHSFRHLF
                     AKNFLAKYNDIALLADLMGHESIETTRIYLRKTATEQQNIVDKIVNW"
BASE COUNT         1088 a          447 c          530 g          985 t
ORIGIN      
        1 tcttatggga ctttttttct acaataaaat aggctccata atatctatag tggatttacc
       61 cactacaaat attatagagc caagaaagat tgcctgtggg taaacagtca cacagcagtc
      121 taagccatca aatacctata acccttaaaa tagcgatttc ggtcgctatt tatttttcga
      181 aaaatcctct tgactctttt gcgaattaga tttatcatca gacgtgtaga agaaaatcaa
      241 ggagtcacta tggaaaaatt caatttcaaa aacaatatcg ggcaagaaaa caagttactt
      301 caaatcgaaa tctacaagtt tactaacttt tgcaagcttc aaaattacac atctgtaaat
      361 attttttcga aagatatatt tgaagccata gtaaattgag actagaatag tacactacat
      421 ctgctaaaaa tttctagaaa ctaatttaac tttcctaatc gatttgttta catcttattt
      481 caatctacta tattatctca ataaatgatg atggcgactg ttttgtttgt gcttgtcgat
      541 ttttgaatcc tgatcgagcg gaagaatatt tctgccgagg ttgccaaggg gaaaatcctg
      601 aagatattga attttatgat gaacaattac aggcagaaaa ggtggaggtt ttgaatattc
      661 gattggaagt aaaaaattga attatctaca atctcatcaa caataaacct atttcaaccc
      721 cattatctat aggcgtattt ttacgccttt ttatatactt gaagcacata agaaacatta
      781 tgggaagttt gctgatggaa gcactcaaga aattgatgtt ccttatgata ttcctgatac
      841 ttgggagtgg gtgaggtttt ctacattggt tgaaattgtc agaggtggct ctccacgacc
      901 aatcaaagat tatcttactt ctgaagtaga tggaataaat tggataaaaa taggtgatac
      961 tgaaaagggt gaaaagtata taaataatgt taaagaaaaa atcaaaaaat cagggcttaa
     1021 caaaactaga tttgtaaaaa aaggtacatt tttgttaact aattctatga gttttggtag
     1081 accttatatt ttgaatgttg atggtgcaat acacgatgga tggttggcta tttcgaacta
     1141 tgaaaactca ttaaataaag attacctatt ctatattctt tcatcaaatg tagtttattc
     1201 tcaatttcta tctctaatta gtggagctgt tgtgaaaaac ttgaatagtg ataaagttgc
     1261 ttctattctt atccctctcc ctccgctagc tgaacaacaa cgcataatag aagcaatcga
     1321 atcagcttta gaaaaagtag atgaatatgc tgaaagttat aatagactag aacagctaga
     1381 taaaaaattt ccagataaac taaaaaaatc tattcttcaa tatgctatgc aaggaaaatt
     1441 agttgaacaa gacccaaatg atgaatcagt cgaagtttta cttgaaaaaa tacgagcaga
     1501 aaaacaaaaa ctctttgaag aaggcaagat taaaaagaaa gatttggaca tttctattgt
     1561 ttcccaagga gatgataact cttattatga ggaagtacct tgtgaaatac cagaaagttg
     1621 ggaatgggtg aggttaaacg atataacctc ctacattcaa agagggaagt ctccaaaata
     1681 ttcaaatatt cctatatacc ctgtgattgc tcagaaatgt aatcaatggt ctggcttttc
     1741 tattgactta gcaagattta ttgatcccga aacagttcat agttaccaga aagaaagatt
     1801 actaagagat ggtgatttaa tgtggaattc aacaggtcta ggtacgttag gacgattagc
     1861 tatttaccat gaaaataaaa atccttatgg ctgggctgtt gcagatagcc atgttacagt
     1921 tataagagtc ttatcgggag ttattaattg ccatttcatc tataattttc tttcctctcc
     1981 tattgttcag tcagttattg aagaaaaagc gtcgggtagt acaaaacaaa aagaattatt
     2041 aacgaaaact ataaaagaat atttaatccc cctcccaccc cttcctgaac aatccagaat
     2101 cgttgataaa atcgaacaat ttttcgccca tattaacgca ctaatttagt ataatagttt
     2161 tacgtgcggt ggaatttcta tcaaacataa gataggagtt ttacgttgaa agattttgaa
     2221 ttacatttga agaaagctgg tttagctgaa aatactgtgc gttcgtacct ttatggtgtt
     2281 cgatttttct tggagaatta cgaactcaaa atggaagatt tatttgaata caaaggatat
     2341 ttattagaca attttaaacc taaaactgtc aatttgcgac tacaaggagt aaataaatat
     2401 ctggctttta ttggtcatga tgatttgaaa ttaaaatttg tcaaagtaca gcaaaaaccg
     2461 tttttagaag atgtcattag ccatgctgat tacctttttc ttaaacgtag tttgaaaaaa
     2521 gatggtattt taaaatggca ttttgtcgtt tggtttttag gtgcaactgg ggctcgtgta
     2581 agtgaactta ttaaactaaa agtagagcat gtagaaatcg gttattttga catttactca
     2641 aaaggtggta aaattcgtag actgtacatt cctaaaaaat taagaaatag ttgtcttagt
     2701 tggttagaat cagaaaatcg ccgaagtggt tatttatttt tgaataaatt taacgaacca
     2761 attacagcaa gaggagttgc tcaacagtta aaaaattatg ctgataaata caaaatgaat
     2821 cctaaagtaa tttaccctca ttcttttagg catttatttg ctaagaattt tttagcgaag
     2881 tataatgata ttgccttgct tgcagatttg atgggacacg aaagtataga aactactcga
     2941 atttatctaa ggaaaacagc tactgaacaa caaaatattg tagataaaat tgttaattgg
     3001 taaaaaataa caggtggtca aactgactac ctgctatttt tgtgattatg
//
LOCUS       DAVLHC010000104         2920 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.105, whole genome shotgun sequence.
ACCESSION   DAVLHC010000104 DAVLHC010000000
VERSION     DAVLHC010000104.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2920)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2920)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2920
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.105"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(21..1376)
                     /gene="rlmD"
                     /locus_tag="VXE25_002119"
     CDS             complement(21..1376)
                     /gene="rlmD"
                     /locus_tag="VXE25_002119"
                     /EC_number="2.1.1.190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="HEV0772506.1"
                     /translation="MNLKVKQKIPLKIKRMGINGEGIGFYQKTLVFVPGALKGEDIYC
                     QITSIRRNFVEAKLLKVNKKSKFRIVPSCTIYNECGGCQIMHLHYDKQLEFKTDLLHQ
                     ALKKFAPAGYENYEIRPTIGMQEPKYYRAKLQFQTRKFKNQVKAGLYAQNSHYLVELK
                     DCLVQDKETQVIANRLAELLTYHQIPITDERKVLGVRTIMVRRARKTGQVQIIIVTNR
                     QLNLTQLVKELVKDFPEVVTVAVNTNTAKTSEIYGEKTEIIWGQESIQEGVLNYEFSL
                     SPRAFYQLNPEQTEVLYSEAVKALDVDKEDHLIDAYCGVGTIGFAFAKKVKTLRGMDI
                     IPEAIEDAKRNAKRMGFDNTHYEAGTAEEIIPRWYKEGYRADALIVDPPRTGLDDKLL
                     DTILTYVPEKMVYISCNVSTLARDLVRLVEVYDLHYIQSVDMFPHTARTEAVVKLIKK
                     V"
     gene            1414..2190
                     /gene="recX"
                     /locus_tag="VXE25_002120"
     CDS             1414..2190
                     /gene="recX"
                     /locus_tag="VXE25_002120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000705102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombination regulator RecX"
                     /protein_id="HEV0772507.1"
                     /translation="MKITKLEKKKRLYLMELDNGDKCYITEDTIVRFMLSRDKVISEE
                     ELKEIQDFAQFSYGKNLALYHLSFKARTEKEVREYLKKYDIDKNIVSQVIANLKEDKW
                     INDGQYAYAIINANQLSGDKGPYVLTQKLAQKGISKSTIEEILNDFDFSEVAQRVANK
                     LLKKYEGKLPARALQDKIIQNLTNKGFSYSDAKIAFDDLDSQVDQETTQELIFKELDK
                     QYTKYARKYEGYELKQRLTQVLARKGYDFSDIASALREYL"
     gene            2279..2812
                     /locus_tag="VXE25_002121"
     CDS             2279..2812
                     /locus_tag="VXE25_002121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000775318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF402 domain-containing protein"
                     /protein_id="HEV0772508.1"
                     /translation="MKLPKEGDFITIQSYKHDGSLHRTWRDTMVLKTTENAIIGVNDH
                     TLVTESDGRRWVTREPAIVYFHKKYWFNIIAMIRDNGTSYYCNMASPYYLDEEALKYI
                     DYDLDVKIFTDGEKRLLDVEEYERHKRKMNYSDDLDYILKEHVKILVDWINNGRGPFS
                     EAYVNIWYKRYVELKNR"
BASE COUNT          933 a          535 c          528 g          924 t
ORIGIN      
        1 atgttttgtc aacacctttt ttaaactttt tttattaatt ttacaacagc ttcagttcga
       61 gctgtatgtg ggaacatatc gaccgactgg atataatgaa gatcatagac ttctactaag
      121 cgtaccaaat cacgagccaa ggtcgaaaca ttacaagaaa tataaaccat tttttctggt
      181 acataagtaa gaatagtatc taataactta tcatccagac ctgtacgtgg tgggtcaaca
      241 atcaaagcat ctgctcggta gccttccttg taccaacgag gaataatctc ttctgccgtt
      301 ccagcttcat aatgagtatt gtcaaatccc attcttttag catttcgctt ggcatcttca
      361 atagcttctg gaataatatc catacctctg agtgttttta ctttctttgc aaaggcaaat
      421 ccaatcgttc caactccaca ataagcgtca atcaaatggt cttctttatc aacatccagc
      481 gcttttactg cttcgctata gaggacttct gtttgctcag gatttagttg ataaaaagct
      541 cgaggggata gtgaaaattc ataattgagt acaccttctt gaatactctc ttgcccccag
      601 ataatctctg tcttttcacc atatatctca ctggttttag ctgtatttgt attaacagct
      661 actgtcacaa cttctgggaa atctttaacc aactctttta ccaattgagt taaattaagc
      721 tggcggtttg taacaataat aatctgaacc tgtccggtct ttctcgcgcg tcggaccata
      781 atagtacgga cacctagaac ttttctctca tccgtgattg gaatctggtg ataagtaagt
      841 aattctgcta agcgattagc aatcacttgg gtttccttat cttgtaccag gcagtctttc
      901 aactctacta aatagtgaga gttttgtgca tataagcccg ccttgacctg atttttaaat
      961 tttcgggtct gaaattgtaa cttagctctg taatattttg gttcctgcat tccaatagtt
     1021 ggacgaattt cataattttc atatcctgca ggagcaaatt ttttcagcgc ttgatgaagt
     1081 aagtccgtct tgaactccag ctgcttatca taatgcaggt gcatgatttg gcagcctccg
     1141 cattcattat aaatagtaca agatggcaca attcgaaatt tagacttctt gttgaccttc
     1201 agtaattttg cttcaacaaa gttgcgtcta atagaagtaa tctgacaata gatatcttcg
     1261 cctttgagag ctcctggtac aaagactaat gttttttggt aaaagccgat tccctcaccg
     1321 ttaattccca tgcgcttgat ttttaatggt attttttgtt tcactttcag attcataccc
     1381 ctatcttatc acattttgag ttataataga gctatgaaaa tcacaaaact tgaaaagaaa
     1441 aaaagactct atctgatgga gcttgataat ggcgacaaat gctatatcac cgaagataca
     1501 attgttcgtt ttatgttatc gagagataag gtgataagcg aagaggaatt gaaagagatt
     1561 caagactttg ctcaattttc ttatggtaag aatctggccc tctaccactt atcctttaaa
     1621 gcacgcactg aaaaagaagt cagagaatat ctgaaaaaat acgatattga taaaaacatc
     1681 gtttctcaag ttattgctaa tcttaaagaa gataagtgga ttaatgatgg tcagtacgct
     1741 tatgctatca tcaatgccaa tcaactttca ggagacaagg gaccttatgt actgactcag
     1801 aaattagcac aaaaaggaat ttcaaaatct actatagaag aaatcttgaa tgattttgat
     1861 ttttcggaag ttgctcaacg tgtagccaat aaactattga aaaaatatga gggaaaactt
     1921 ccagctcgtg ccctgcaaga taagattatc cagaacttga ctaacaaggg cttctcttat
     1981 tctgatgcta aaattgcctt tgacgactta gatagccaag ttgaccaaga aacgactcaa
     2041 gaactcatct tcaaggaact tgataagcaa tatactaagt atgctcgaaa gtatgaagga
     2101 tacgaactga agcagcgttt aactcaagtt ttagcacgaa agggctacga tttttcggat
     2161 atagcaagcg ctcttagaga atatctttaa tatttccaag tgaaattcac agattttagg
     2221 taattttatg gtacaatagt aaatgataaa cttataaatt gtagaaagtt ggttagttat
     2281 gaagcttcca aaagaaggcg actttattac aattcaaagt tataagcatg atgggagtct
     2341 ccaccgaact tggcgggaca ccatggtact aaaaacaaca gaaaacgcca ttattggtgt
     2401 caacgatcat acacttgtta ccgaaagtga tggtcgtcgt tgggtcactc gagaaccggc
     2461 tattgtttac tttcacaaga aatattggtt taatatcatt gccatgattc gtgataatgg
     2521 aacttcttac tattgcaata tggctagccc ctactatctg gatgaagaag cactgaagta
     2581 tattgattac gatttggatg ttaaaatttt tacagatggg gaaaaacgtc tcttggacgt
     2641 tgaagagtac gagcgtcaca aacgcaaaat gaattattct gatgacttgg actatatttt
     2701 aaaagaacat gtcaaaattc ttgttgattg gattaacaat ggacgtggtc ctttctcaga
     2761 agcctatgta aacatttggt acaagcgcta tgtagaacta aagaatcggt aaagttgtca
     2821 aaggtcagga acaaaatcct gacctttttt tggtagtata aaataaattg tgtaaacaca
     2881 aaaaggaata aatctattat agcagagtta caacacatta
//
LOCUS       DAVLHC010000105         2780 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.106, whole genome shotgun sequence.
ACCESSION   DAVLHC010000105 DAVLHC010000000
VERSION     DAVLHC010000105.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2780)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2780)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2780
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.106"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..547
                     /locus_tag="VXE25_002122"
     CDS             <1..547
                     /locus_tag="VXE25_002122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000982805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772509.1"
                     /translation="GIAFTNSLEMYNVLKPLDNSIVEGLLRKEFTSKKLYSPVVTSLT
                     LKAMPFIKYLLTDLVYFDNGYIIPFGFRYTDMVKLKTDTIHCSIFDNLFGTLPFKFEP
                     LEQYQIIYDAQNSEIVVNVLNLEVTQGDIVCSVLKEYIKEHYKSSIKVSLRNCSKFFR
                     DNLTGKMRGIINKENINNEIW"
     gene            563..2068
                     /locus_tag="VXE25_002123"
     CDS             563..2068
                     /locus_tag="VXE25_002123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000368300.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal-dependent decarboxylase"
                     /protein_id="HEV0772510.1"
                     /translation="MDNENEISKFFLSSENVKDMKTIANDILNMGLDFKLSEKVSQKK
                     MKEHDDLNFLSLEESIDNLPQLLEEFREKVIPYCTNFSSPNFMGFPDSGNSLGGLSGS
                     LLSDLLQQNLINASFCAPVATIMEINVIQWLRKVLGYSTSDVHNIMEVGGIVTYGGTG
                     SNSTAMLLARENKDGNTLELGVRNPRNYKVIVPKGIGHYSIASSLKWLGLGNNIIEVP
                     TENYRYNLKKLREALINHSNEIMAVVAYAGDSRTMTIDNLSEVADLVKTLTPNVWLHC
                     DACHGFSLAFSKKYKDRIKGIEKFDSISTDPHKVLGIPYCISVLLVKTPQSLNLIHSQ
                     SDLIMNENLALGQTTPFLGSKSWISLKLWLVAKHLGSEKIGAMVDKRIELTNYLQDLI
                     LKSSKLILLNRTDINSVMFMYIGDKHQEVSLSSVQNINNINKSIYDRLKDEGIYYLHQ
                     FPIIDNTETIYRGFELCPLRFMSGNPNLTIEELQKMVIEVENLGDRFVGES"
     gene            2072..>2780
                     /locus_tag="VXE25_002124"
     CDS             2072..>2780
                     /locus_tag="VXE25_002124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AMP-binding protein"
                     /protein_id="HEV0772511.1"
                     /translation="MSKELYNKFILTKEAGNIIYDGIEFGRDEIDRRILEISKILTAD
                     IVNLSQEAVAISCNKKINFFFLFLVVNCCDGVVMPVYARTPENKLQHICERYDINYMV
                     SDHEINLVGYSLIYHGSVFSEEYFIYECNKSFPKHEELKGIELLMLSSGTTGVSKAIS
                     LSLDNILSNTRSIQKYIIPTREDRCLIIKEITHSSSLISELINSLLSKNSVLLSDLIP
                     TVSSLGYLISTYGVTILY"
BASE COUNT         1017 a          349 c          506 g          908 t
ORIGIN      
        1 gggaattgca tttacaaatt cattagaaat gtataatgta cttaaaccat tagataattc
       61 tatagttgaa ggtctgctga gaaaagaatt tacttctaaa aaattatata gtccagttgt
      121 tacttcacta actctaaagg caatgccatt tataaaatat ttacttactg atttggttta
      181 ctttgataat gggtatatta tcccgtttgg ctttagatac acagacatgg taaaactaaa
      241 aacagatacc atccattgtt caatatttga taatttattt ggaacattac catttaaatt
      301 tgaaccttta gaacagtatc agattatcta cgatgctcaa aattcagaga ttgtggttaa
      361 tgttctaaat ttagaagtga cacaaggtga tattgtttgc tcggttttaa aagaatatat
      421 caaagaacac tacaaaagtt caataaaagt ttctcttcga aattgttcaa aattttttag
      481 agataatctg acaggaaaaa tgcgtgggat aataaataaa gagaatataa ataatgaaat
      541 ttggtaggag gcaaactcat acatggataa tgaaaacgaa atttcaaagt tttttctgag
      601 ttcagaaaat gtaaaagata tgaaaactat cgcaaatgac attttaaata tggggttgga
      661 ttttaaatta agcgaaaaag tttctcagaa aaaaatgaaa gaacacgatg atttaaattt
      721 tctcagctta gaagagagta tagacaatct tccgcaactt ttggaagaat tcagggaaaa
      781 agtaattcct tactgtacaa atttttcttc ccctaatttt atgggttttc ctgactcagg
      841 aaattcatta ggcggtcttt caggtagttt gcttagtgat ttattacagc aaaatttgat
      901 taatgcatct ttttgcgctc ccgttgctac tattatggaa ataaatgtaa tccagtggtt
      961 acgaaaagtt ttaggatatt ccacttctga tgttcataat attatggaag taggcggcat
     1021 cgttacctat ggtggtacag gaagtaattc tacagctatg cttttagcaa gagaaaataa
     1081 agatggaaat actcttgaat taggcgtaag aaaccccaga aactataagg taattgtgcc
     1141 aaaaggaatt ggtcattata gtatcgcatc aagtttaaag tggctgggat tggggaataa
     1201 tattattgaa gttcctacag aaaattatcg ctataacttg aagaaactta gggaagcact
     1261 aatcaaccat tctaatgaaa taatggcagt ggttgcatat gctggagata gtagaacaat
     1321 gactattgat aatctatctg aagtagcaga tttggtaaag acacttaccc caaatgtttg
     1381 gttacactgt gatgcttgtc acggattttc attagctttt tctaaaaagt ataaagatag
     1441 gataaaagga attgaaaaat ttgatagtat ttcgacagat ccgcataaag ttttaggaat
     1501 tccttattgc ataagtgttt tgttagtgaa aacacctcaa tcgcttaatc taattcactc
     1561 tcaatcagat ttgattatga atgaaaactt ggcccttggg caaacgactc catttttggg
     1621 aagtaaaagt tggatatctc taaaattgtg gttagtagct aaacatttag gatcagagaa
     1681 aataggagcg atggtagaca agagaataga gttaacgaat tatttgcaag atctaatact
     1741 taagagttct aagttaatat tattaaatag gacagatatt aattcagtta tgttcatgta
     1801 tataggtgat aaacatcaag aagtaagctt atcatcagta cagaatataa ataacattaa
     1861 taagagtatt tatgacagac taaaagatga aggaatatac tacctacatc aatttccaat
     1921 aatagataat acagaaacca tatacagagg gtttgaatta tgtccattac gatttatgtc
     1981 tggaaatcct aatttaacaa ttgaagaact acaaaaaatg gttatagaag tagaaaatct
     2041 aggggataga tttgtaggag agagttaaaa aatgagtaaa gagctctata ataaatttat
     2101 tttgacaaag gaagctggaa atataatata tgacggcatt gaatttggca gggatgaaat
     2161 tgataggaga attctcgaaa tttctaaaat acttactgca gatattgtca acttatcaca
     2221 agaagcagtt gctataagtt gtaataaaaa aataaacttt ttctttcttt ttctggtagt
     2281 taattgttgt gatggtgttg ttatgccagt gtatgctaga acgccagaaa ataaattaca
     2341 acatatctgt gaaaggtatg acataaacta tatggtttct gaccatgaaa ttaatttggt
     2401 agggtatagt ttaatatatc atgggagtgt tttttcagaa gagtatttta tatacgagtg
     2461 taataaatca tttccgaaac atgaggagtt gaaggggatt gaattgttaa tgctctcttc
     2521 aggtactaca ggagtttcaa aagcgattag tttatcgctt gataatattt tatctaatac
     2581 tagaagcatt caaaaatata ttattcctac tagagaagat aggtgtctca taataaaaga
     2641 aatcacacac tcgtcgtcat tgatatcaga attaataaat agtttgttat caaaaaattc
     2701 agtgttgtta agcgatttaa ttccgaccgt tagttcatta gggtatttaa taagtacata
     2761 cggtgtgact attttatacg
//
LOCUS       DAVLHC010000106         2771 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.107, whole genome shotgun sequence.
ACCESSION   DAVLHC010000106 DAVLHC010000000
VERSION     DAVLHC010000106.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2771)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2771)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2771
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.107"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(<1..400)
                     /locus_tag="VXE25_002125"
     CDS             complement(<1..400)
                     /locus_tag="VXE25_002125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772512.1"
                     /translation="MTTKKANITIEEYIEMSEVDFNEAVNYEFTSDTCQLANSIYQSL
                     FKFFDKKNFSGDLIFTWKSPSLVKEGDYIGRRDSQVDNLRVIGNIFPNYLTNRKYSLN
                     MNRNGCIGDFPHDFFDTYLDHVAKYAYEQKV"
     gene            complement(414..1127)
                     /locus_tag="VXE25_002126"
     CDS             complement(414..1127)
                     /locus_tag="VXE25_002126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000499426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YjjG family noncanonical pyrimidine
                     nucleotidase"
                     /protein_id="HEV0772513.1"
                     /translation="MFYKFLLFDLDHTLLDFDAAEDVALTQLLKEEGVADIQAYKDYY
                     VPMNKALWKDLELKKISKQELVNTRFSRLFSHFGQEKDGSFLAQRYQFYLAQQGQTLS
                     GAHDLLDSLIERDYDLYAATNGITAIQTGRLAQSGLVPYFNQVFISEQLQTQKPDALF
                     YEKIGQQIAGFSKEKTLMIGDSLTADIQGGNNAGIDTIWYNPHHLENHTQAQPTYEVY
                     SYQDLLDCLDKNILEKITF"
     gene            complement(1586..1960)
                     /locus_tag="VXE25_002127"
     CDS             complement(1586..1960)
                     /locus_tag="VXE25_002127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002960428.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS-dependent dihydroxyacetone kinase
                     phosphotransferase subunit DhaM"
                     /protein_id="HEV0772514.1"
                     /translation="MESIGLVIVSHSKHIAEGVVELISKVAKDVPITYVGGTEGGGIG
                     TSFDQVDRVVSENPADTLLAFFDLGSAKMNLKMVTDFSDKSIIINRVPIVEGAYNAAA
                     LLQAGAELSVIQTQLAELEINK"
     gene            complement(2379..>2771)
                     /locus_tag="VXE25_002128"
     CDS             complement(2379..>2771)
                     /locus_tag="VXE25_002128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine motif-containing protein"
                     /protein_id="HEV0772515.1"
                     /translation="DHVQRNKNGQADTNQTEKPSEEKPQTEKPEEETPREEKPQSEKP
                     ESPKPTEEPEEESPEESEEPQVETEKVEEKLREAEDLLGKIQDPIIKSNAKETLTGLK
                     NNLLFGTQDNNTIMAEAEKLLALLKENK"
BASE COUNT          846 a          542 c          439 g          944 t
ORIGIN      
        1 taactttttg ttcgtaggca tattttgcta catgatctag gtatgtatca aaaaagtcat
       61 gaggaaaatc tcctatacag ccattacgat tcatattgag gctatatttt cgattagtaa
      121 gataattcgg aaatatattt cctattactc taagattatc tacttgtgaa tcccttctcc
      181 caatataatc cccttctttg actaatgatg gagatttcca agtaaaaatt aaatcgccag
      241 agaaattttt cttatcaaaa aacttaaaaa gagattgata aatactattt gctaattgac
      301 aagtgtcaga tgtaaattca taattaacag cttcattaaa atcaacttca gacatttcaa
      361 tgtactcttc aatagtaata ttagcttttt ttgtagtcat tagctaatct cctttaaaat
      421 gtgatctttt caagaatatt tttatctaaa caatccagca agtcttggta agaatagact
      481 tcgtaagtcg gctgggcttg tgtgtgattt tcgaggtgat gaggattata ccagatagtg
      541 tcaatccccg cattattgcc accttgaatg tcggcggtta gagaatctcc aatcatcagc
      601 gtcttttctt tactaaatcc agcaatttgc tggccaatct tttcataaaa gagagcatcc
      661 ggcttttgag tttgcaactg ttctgagata aagacttgat tgaaataagg tactagacca
      721 gattgagcca aacgtcctgt ctgaatggca gtaatgccat ttgtcgcagc atacaagtca
      781 taatcacgct caatgaggct gtccaagaga tcatgagcgc ccgatagtgt ttgtccctgc
      841 tgagcgagat aaaattggta acgctgggca agaaaactac cgtctttttc ctgtccaaaa
      901 tgagaaaata aacgagaaaa gcgcgtgtta accagctctt gtttactgat tttcttcagc
      961 tccaagtctt tccagagagc cttgttcata ggaacgtaat aatctttata agcctgaata
     1021 tccgcaactc cttcttcttt tagaagttgg gtcaaagcca catcctcagc agcatcaaaa
     1081 tcaagaagag tgtggtcgag gtcgaagagt agaaatttgt agaacaattt gaggttttcc
     1141 tttctgaaaa ttcattaaga acattatatc ataaagcacc tcatacaatt aactaattta
     1201 atcacttaaa aaaaattcga acactttcta tacaactgac agctcaaatc tttcagaata
     1261 gaacaatact aactatcgaa caccccgtct tcataaatac atatgtaatt ctaggcctag
     1321 aattcctata aactaaatgc tttcatactc ttccaagtaa ttgattgcct taaattttaa
     1381 tttttgaagg attctaaagc tagaatagcc ccatcacaat cagttttgat tgattcacaa
     1441 tttagaaaca ctatagtttc actcctgtta aaataaaaag gaactgcata aagcaatccc
     1501 tttctgattt tgaaatcatt tacttaacat tttatagttg agataatcaa tagcttacct
     1561 ataaaaagag ttatagtaaa attccttatt tattgatttc aagctccgct aactgtgttt
     1621 gaataactga cagttctgca ccagcctgaa gaagagcagc tgcattatag gcaccttcta
     1681 caattggaac cctgttgatg atgatacttt tatcactgaa atcagtcacc atttttaagt
     1741 tcattttagc agaacctagg tcaaaaaagg caagtaaagt atctgctgga ttttcggaaa
     1801 caaccctatc tacttgatca aaactcgttc caattcctcc gccctcggtt cctcctacat
     1861 aagtaatcgg aacatcttta gctactttac taatcagttc aacaacacct tctgcaatgt
     1921 gtttggaatg tgaaacgata acaagaccaa tactttccat caaaccaccc cagtttctaa
     1981 aatagcagta aatagtaatc ctgatgagaa tgatccagga tcgatatgtc caaaaaacca
     2041 catgctccta agacaagagc caacagactg gccatcaata atagtattgt tcttttttat
     2101 cattactcct taactagtgt ttaactgatt aattagccag taaatagttt acctttattt
     2161 acactatctg ttaagatata gtaaaatgaa ataagaacag gacagtcaaa tcgatttcta
     2221 acaatgtttt agaagtagag gtatactatt ctaatttcaa tctactatat tttgcacatt
     2281 ttcataaaaa aatgagaact agaactcaca ttctgctctc atttttcgtt ttcccgttct
     2341 cctatcctgt ttttaggagt tagaaaatgc tgctaccttt acttattctc ctttaataaa
     2401 gccaatagtt tttcagcttc tgccataata gtattgttgt cctgggtgcc aaatagtaaa
     2461 ttatttttta atcctgtgag agtctctttg gcattggact tgataattgg atcctggatt
     2521 tttccaagta aatcttcagc ctctctcagt ttttcttcaa ccttttcagt ctcgacctga
     2581 ggttcttctg attcctctgg tgattcttct tctggttcct ctgttggttt tggagactct
     2641 ggtttctcgc tttgcggttt ctcttctcga ggggtttctt cctcaggttt ttctgtctga
     2701 ggtttctcct cgcttggttt ttccgtttga ttggtatcag cttgaccatt tttgtttctt
     2761 tgaacatggt c
//
LOCUS       DAVLHC010000107         2684 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.108, whole genome shotgun sequence.
ACCESSION   DAVLHC010000107 DAVLHC010000000
VERSION     DAVLHC010000107.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2684)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2684)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2684
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.108"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(28..873)
                     /locus_tag="VXE25_002129"
                     /pseudo
     CDS             complement(28..873)
                     /locus_tag="VXE25_002129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
     gene            950..1405
                     /locus_tag="VXE25_002130"
     CDS             950..1405
                     /locus_tag="VXE25_002130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001811998.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HEV0772516.1"
                     /translation="MQWQTQLSEKKANTDYIARYGVYAVIPNPEQKQIVLVQEPNGAW
                     FLPCGEIEAGENHQEALKRELIEELGFTAEIGTYYGQADEYFYSRHRDTYYSNPAYLY
                     EATPFKEVQKPLENFNHIAWFPIDEAIKNLKRGSHKWAIESWKKQHKID"
     gene            1570..1869
                     /locus_tag="VXE25_002131"
     CDS             1570..1869
                     /locus_tag="VXE25_002131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000767202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1827 family protein"
                     /protein_id="HEV0772517.1"
                     /translation="MKLINTTNSHSQLVKSQLESTDATLVEVYSAGNTDVIFTQAPLH
                     YEILISNKHRAIREPEIETIQEFFLKRKIDKTSVDEANIKTLYSEKLIGISIPIK"
     gene            2129..2452
                     /gene="tnpB"
                     /locus_tag="VXE25_002132"
                     /pseudo
     CDS             2129..2452
                     /gene="tnpB"
                     /locus_tag="VXE25_002132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846105.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family insertion sequence element accessory
                     protein TnpB"
BASE COUNT          858 a          512 c          471 g          843 t
ORIGIN      
        1 ttctcatctt atttcaatct gctatagtca attgaaacaa gaacaagaca aaagagcctc
       61 ataaaaggta ttgcaacttg gtaatacctt tttgaggttc tttttgatat gaacccatgt
      121 tttctcaata ggattgtact caggcgagta gggaggaaga ggtaaaagtt tatgcccaaa
      181 ctcttcgcat aaaagttcta gcttccccat tctatggaat cttgcattat ccataataat
      241 aaccgatggt gtggttaatg ttggtaagag aaacttctga aaccaagctt caaaaaagtc
      301 gctcgtcatc gtctcttcgt aagtcattgg agcgattaat tcaccatttg ttagacctgc
      361 aaccaaagaa atcctctgat atcttcttcc agatactttg cctcttatta actgaccttt
      421 taatgagcga ccatattctc gataaaaata agtatcgaat cctgtttcgt caatctaaac
      481 aggtgctagg tgctttaaac tattaaaatt cttaagaaat aaggctactt tttctgggtc
      541 ttgttcatag taggtgtggt tcttttttcg agtgtagccc atagctttga gcgcatagtg
      601 gatggtagtt ggatgacagc caaattcaga agctatttca gtcaaataag cgtctggatt
      661 gtcagtaaga tagtttttaa gtctatctct atcaactttt cttggttttg ttccttttac
      721 ttggtggttt agctctcctg ttttctcttt tagctttaac cagccataaa tggtattacg
      781 tgagatttgg aaaacgtgtg atgcttctgt tatactacct attcgctcac aataagagag
      841 aactttttta cgaaaatcta ttgaatatgc cataagaaga ttataccaca ttgtgtacta
      901 tttttggttc atttcactat aataataacg atactagata atgaggaaaa tgcaatggca
      961 aacccaactt tcggagaaaa aagcgaatac agactatatt gctcgctatg gcgtatatgc
     1021 agttatccct aatcctgaac aaaaacaaat tgttcttgtt caagaaccaa atggtgcttg
     1081 gttcctacca tgtggagaaa ttgaagcagg tgaaaatcat caggaagccc taaagcgtga
     1141 gttgattgaa gagcttggtt tcacagcaga aattggtacc tattacggac aagctgacga
     1201 atatttctat tctcgtcatc gtgataccta ctactccaat cctgcctacc tctatgaagc
     1261 aactcctttc aaagaagtac aaaagccact agaaaacttt aatcatattg cctggttccc
     1321 tattgacgag gctatcaaaa accttaaacg tggtagccat aaatgggcca ttgaatcttg
     1381 gaaaaaacag cataagattg actaatactc ttcgaaaata aaattcaaac cacatcagcg
     1441 tcgccttacc atactcaagt atagcctgcg gctagcttcc tagtttgctc ttttattttc
     1501 attgagtata aatcaagcga ctttattcaa aaagtgctat aatagaatta gaaaaccgga
     1561 ggaaatatta tgaagcttat caatacgaca aactcacact cgcaacttgt aaaaagtcag
     1621 ctagaaagta ccgatgcaac ccttgttgag gtttattctg cagggaatac agatgttatt
     1681 tttacccaag ctccgcttca ctatgaaatc ctcatctcaa acaaacaccg tgctattcgt
     1741 gagcctgaaa tcgaaaccat tcaagaattt ttcttgaaac gtaaaattga taagacctct
     1801 gttgatgaag ccaatatcaa gacactctac tcagagaaat taattggaat ttcaatccca
     1861 atcaagtaag aaaattgagt aaaaactcga tttgagagaa agtccaataa gtctttccat
     1921 aacaaaacgc atagtaacaa gagtttctac acccactatt atgcgttttt atcattttga
     1981 aatctactgc aatcaatgaa gaagcaaaga tcaaactagg cagctagtta caagttacgt
     2041 aagcgcgtca taacaaggta tctatcctaa ttccccaact tccagtatac tagataaaaa
     2101 ataattatcg gaggaaaggt attgtactat gataattcaa ctaagtgatt taggtcaagt
     2161 tcaccttgtt tgtggtaaga cagatatgag gtagggaata gactcattag cctatgtagt
     2221 taaaacccac tttgaattgg attctttctc cggtcaagtc tttctctttt gtggtggacg
     2281 taaagaccgc tttaaagccc tttactggga tggtcaagga ttttggctac tatataaacg
     2341 ctttgagaac ggaaaactga cttggctaag tacagaaaag gatgtcaaag ctctcgcacc
     2401 tgaacaagta gattggctga tgaagggctt ttctatcact ccaaaaatat agtagattga
     2461 aactagaata gtacacctct gcttctaaaa tattgttaga aatcgatttg tcctgttctt
     2521 atttcatttt actataaatc catcagaaag tcgtgatttc tattgaaatg aggactttct
     2581 ttttatactc atctgctttc aaaaagcatt ctagtccatc tccgattaac gatggacttt
     2641 atcacctcct tctccagtcc ttgtatgaca tcttggagtt gatt
//
LOCUS       DAVLHC010000108         2632 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.109, whole genome shotgun sequence.
ACCESSION   DAVLHC010000108 DAVLHC010000000
VERSION     DAVLHC010000108.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2632)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2632)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2632
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.109"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(277..834)
                     /gene="sdbB"
                     /locus_tag="VXE25_002133"
     CDS             complement(277..834)
                     /gene="sdbB"
                     /locus_tag="VXE25_002133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000757364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol-disulfide oxidoreductase-associated
                     lipoprotein SdbB"
                     /protein_id="HEV0772518.1"
                     /translation="MKKVMFAGLSLLSLVVLMACGQEETKKTQAAQQPKQQTTVQQIA
                     VGKDAPDFTLQSMDGKEVKLSDFKGKKVYLKFWASWCGPCKKSMPELMELAAKPDRDF
                     EILTVIAPGIQGEKTVEQFPQWFQEQGYKDIPVLYDTKATTFQAYQIRSIPTEYLIDS
                     QGKIGKIQFGAISNADAEAAFKEMN"
     gene            complement(845..1552)
                     /gene="ccdA2"
                     /locus_tag="VXE25_002134"
     CDS             complement(845..1552)
                     /gene="ccdA2"
                     /locus_tag="VXE25_002134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004237834.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol-disulfide oxidoreductase-associated
                     membrane protein CcdA2"
                     /protein_id="HEV0772519.1"
                     /translation="METIVFLISVFLAGVLSFFSPCIFPLLPVYAGILLDDQESAKSF
                     SLFGRKVLWSGLIRTLCFIAGISLIFFILGFGAGYFGHILYANWFRYVMGAIIIILGL
                     HQMEIFHLKKLEVQKSFTFKKSDSNRYWSAFLLGITFSFGWTPCIGPVLSSVLALAAS
                     GGNGAWQGAIYTLIYTLGMALPFLVLALASGLVMPYFSKIKRHMMLLKKIGGFLIVLM
                     GILLLLGQVNVLAGIFE"
     gene            complement(1783..2199)
                     /locus_tag="VXE25_002135"
     CDS             complement(1783..2199)
                     /locus_tag="VXE25_002135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000642281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772520.1"
                     /translation="MKAALDSLKDVKANASDSKPAQDKKDAKQGMEDSKDSDKMTETN
                     SVPAGVIVVSLLALLGVIAFWLIRRKKESEIQQLSTELIKVLGQLDAEKADKKVLAKA
                     QNLLQETLDFVKEENGSAETETKLVEELKAILDKLK"
     gene            complement(2224..2424)
                     /locus_tag="VXE25_002136"
     CDS             complement(2224..2424)
                     /locus_tag="VXE25_002136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000226586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772521.1"
                     /translation="MVASASASSTSTQAQEQVDKSELRALSQELDQRLKALATVSDPK
                     IDATKAVLLDAQKAPEDSALTE"
BASE COUNT          777 a          549 c          476 g          830 t
ORIGIN      
        1 taacttctca aagtaacttc catctctctc ccaaaactgg aagttactct aagacgactc
       61 tgttttaggg ctatttgtcg tgcacttttt ctgagtcttt tcgcttttga acccttatat
      121 atcaagaaaa agaaaaccag tgaaagttag tctaagacgg atttccactg atgtcacgcg
      181 tttttctcat actaaaagct aagttgtggg aaactggaag ttagttttag aagttaccaa
      241 aatctgacta catcttgtaa tcagatttta tcgattctag ttcatttctt taaatgctgc
      301 ttctgcatcc gcattactga tagcaccaaa ttgaatcttt ccaatctttc cttggctatc
      361 aattaaatat tctgtaggaa tgcttcgaat ttgataagct tggaaggtgg ttgctttggt
      421 atcataaaga actgggatat ccttatatcc ttgttcctgg aaccattgtg ggaattgctc
      481 aacagttttt tcaccttgaa ttcctggtgc aatgacagta agaatttcga aatcacgatc
      541 tggtttcgcc gctagttcca tcaactctgg catacttttc ttgcatggac cacaccatga
      601 agcccaaaac ttcaagtaaa cctttttacc cttaaaatca gataacttaa cttctttgcc
      661 atccatggat tgcaatgtaa agtctggagc atcttttcca acagcaattt gttgtacagt
      721 cgtttgttgt tttggctgtt gtgctgcttg agtcttttta gtttcttcct gaccacaggc
      781 catcaataca actaatgaca agagacttaa gccagcaaac attacttttt tcatttgtcc
      841 tcctttattc aaaaattcca gctagaacat ttacttgtcc taatagtaac aaaattccca
      901 ttaaaacaat gaggaaacca ccaattttct ttagtagcat catatgacgc ttgattttac
      961 taaaatatgg catgactaga cctgaagcta gtgccaagac caagaaagga agggccatgc
     1021 ccagagtgta aatgagagta taaatcgctc cttgccaagc accattgcct ccagaagccg
     1081 caagtgctaa aacagaactt aaaactggac caatacaagg tgtccaacca aagctaaagg
     1141 taataccaag taaaaaagct gaccaataac gattagaatc tgatttttta aaggtaaaac
     1201 ttttttgaac ttctaatttc ttcaaatgaa aaatttccat ctggtgaaga cccaaaatga
     1261 taataatagc tcccatgaca tatcgaaacc aatttgcata gagaatatga ccaaagtaac
     1321 cagcaccaaa gcctagaata aagaaaatga gagagatacc agcgataaag caaagtgttc
     1381 gaatcaagcc tgaccagaga acctttctcc caaacaaaga aaagcttttt gcactttctt
     1441 gatcatccaa taaaatccca gcatagactg gcagaagagg aaaaatacaa ggagaaaaaa
     1501 aggataaaac acctgctaga aaaacagaga ttaaaaatac tatcgtttcc aataaagaac
     1561 caactttctt aataattcta atcctatttt actatattca attttatttg taagctttct
     1621 gctacgcaaa atcgtatcgg gcactattgg accaatcttt tcttttgcta gtcaaggcgg
     1681 atcttatccc ccaaaatagc caaaaagcaa cgacaaggat tactcgtcac tgcttttgtg
     1741 aacgaaaatg tcttttaggt ctgacatttc ataaatcatg ttttacttga gtttgtcaag
     1801 gattgcttta agctcctcta ctagtttagt ttctgtctct gctgagccat tttcttcttt
     1861 cacgaaatca agggtttctt ggagaaggtt ttgggctttg gcaaggactt ttttatccgc
     1921 tttttctgca tctagctgtc ctagaacctt gatcaattcc gtgcttaatt gctggatttc
     1981 tgactctttc ttacggcgaa tcagccagaa ggcaatcacg cctaggaggg caagtagact
     2041 gaccacaatc actcctgccg gaactgagtt tgtttcagtc atcttatctg aatccttact
     2101 atcttccatt ccttgttttg catccttctt gtcctgtgca ggcttgctgt cgctagcatt
     2161 tgctttcaca tctttgagag agtccaaggc agccttcaca gactctactg cagtatgcag
     2221 accttactct gtcaaggcac tatcttccgg agctttttga gcatctagga ggacagcctt
     2281 ggttgcatcg atttttggat cagatactgt tgccaaagct ttcaagcgtt ggtctaactc
     2341 ttgactcaag gcacgaagtt cagacttgtc aacttgctct tgagcttgtg tgctcgttga
     2401 gctagccgaa gcgcttgcta ccactctagg atcttgagtc ggagctgagc ttggagctgg
     2461 gacaggactt gcaggttgac taggagcagt tatggtatat tgaaactaga atagtacata
     2521 tagacttcta aaacattgtt agaattcgat tttactgtcc tgatcgattt gtcctgttct
     2581 tatttcattt tactctaata accgatggtg tggttaatgt tggtaagaga aa
//
LOCUS       DAVLHC010000109         2627 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.110, whole genome shotgun sequence.
ACCESSION   DAVLHC010000109 DAVLHC010000000
VERSION     DAVLHC010000109.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2627)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2627)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2627
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.110"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(79..284)
                     /locus_tag="VXE25_002137"
                     /pseudo
     CDS             complement(79..284)
                     /locus_tag="VXE25_002137"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844775.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
     gene            722..1639
                     /locus_tag="VXE25_002138"
     CDS             722..1639
                     /locus_tag="VXE25_002138"
                     /EC_number="2.7.1.26"
                     /EC_number="2.7.7.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000587449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional riboflavin kinase/FAD synthetase"
                     /protein_id="HEV0772522.1"
                     /translation="MIITIPIKNQKDIGTPSDSVVVLGYFDGIHKGHQELFRVANKAA
                     RKDLLPIVVMTFNESPKIALEPYHPDLFLHILNPAERERKLKREGVEELYLLDFSSQF
                     ASLTAQEFFATYIKAMNAKIIVAGFDYTFGSDKKTAEDLKDYFDGEVIIVPPVEDEKG
                     KISSTRIRQAILDGNVKEAGKLLGAPLPSRGMVVHGNARGRTIGYPTANLVLLDRTYM
                     PADGVYVVDVEIQRQKYRAMASVGKNVTFDGEEARFEVNIFDFNQDIYGETVMVYWLD
                     RIRDMTKFDSVDQLVEQLKADEEVTRNWS"
     gene            complement(1732..2580)
                     /locus_tag="VXE25_002139"
     CDS             complement(1732..2580)
                     /locus_tag="VXE25_002139"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000592058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HEV0772523.1"
                     /translation="MIKKIYPIFTILLGAAIYAFGLTYFVVPHHLFEGGATGITLITF
                     YLFKIPVSLMNLLINIPLFILAWKIFGAKSLYSSLLGTLALSGWLAFFEHIPLHIDLQ
                     GDLLITALIAGILLGIGLGIIFNAGGTTGGTDILARILNKYTHISIGKLLFILDFCIL
                     MLILLIFKDLRLVSYTLLFDFIVSRVIDLIGEGGYAGKGFMIITKRPDQLAKAINDDL
                     GRGVTFISGQGYYSKENLKIIYCIVGRNEIVKTKEMIHRIDPQAFITITEAHEILGEG
                     FTFEKE"
BASE COUNT          852 a          435 c          517 g          823 t
ORIGIN      
        1 taattttcat tgagtatgaa tctggaatag aacactgtta aaaattgata tgagtttcct
       61 actcgatttc ttcagatttt atttcaattg actataagaa ctgctatctg gtttcaaata
      121 ttggcttgtc gtcccttcac ttgtctgaat ggtttgagcc gttccttctg ataagggaaa
      181 agatattctt tagctgaaac ggtctgagaa tccaagctaa cagatggaga gaaaaatagc
      241 ctagtctgaa gcacactaga tgggagttgt tggaaagcag tcatctagtt tttctttgct
      301 gttttggctt ttttctttgt catcagggaa agtgacttgc ttcaaatcag ggagtttagg
      361 aaattcttca aacatcttgc ccaagttgtc tcattttgta aattttacag ccataggtgt
      421 acctcgattc taaattctac cttttcggca ccaattagta atttaaagtt ctcaggagtt
      481 agttgcattg ctttttcata cataagcata gtatgacact ttatggttac cgaacaagtc
      541 taatcactcc ttgcaaaatt ttgaagatgt cctacaagtt tttgagaaga atattgcaaa
      601 gttcatagtt aagcaacgat agaataaagt gctttttgaa aacaggtaca cttcatgtga
      661 aaaaaacaac atttcagatt ttctgttcca gaaatagcta tcgctatgat ataattattt
      721 tatgattatt actattccta taaaaaacca aaaagatatt ggcacaccat ctgattcagt
      781 cgttgttctc ggctattttg atggcataca taaggggcat caagaattat ttcgtgttgc
      841 caacaaggct gcgagaaagg atttattacc tatcgtcgtt atgaccttta atgaatctcc
      901 aaagatcgct ttagagcctt atcatccaga tttgtttttg catattttga accctgctga
      961 acgtgaaaga aaattaaagc gcgaaggtgt agaagaatta tatctccttg attttagtag
     1021 tcaattcgct agtctcactg cacaagaatt ctttgcaact tatatcaagg ctatgaatgc
     1081 caaaattatt gttgcaggtt ttgattatac atttggttct gacaaaaaaa cagcagaaga
     1141 tttaaaggat tactttgatg gagaagttat cattgttcca cctgtagaag atgagaaagg
     1201 aaagattagt tcaactcgta tccgtcaagc tattttagat ggaaatgtga aagaagcagg
     1261 aaaacttttg ggggcaccgc ttccatcaag aggtatggtg gttcatggta atgctcgtgg
     1321 tcgtacaatt ggttatccga cagcgaattt agtgctttta gaccgtactt atatgccagc
     1381 agatggcgtt tatgtcgttg atgttgagat tcaaagacag aagtatcgtg ctatggctag
     1441 tgtcgggaaa aatgtgacct ttgatggaga agaagcacgt tttgaagtca atatttttga
     1501 ttttaatcaa gatatttatg gggaaaccgt catggtttat tggcttgatc gcattcgtga
     1561 tatgaccaaa tttgactcag ttgaccaatt agtggaacag ttaaaggctg atgaagaagt
     1621 aactcggaat tggtcttaag agcttgagta aataaaacaa aaaagaggtt gtctgtaacc
     1681 caaaagatag atgatttagt ctaacttttg aggtcacgac actacctctt tttattcttt
     1741 ttcaaaggtg aagccttctc ctaggatttc atgggcttct gtaatagtta taaaggcttg
     1801 aggatcgatt cgatgaatca tttccttcgt tttcacaatt tcatttcttc cgacaataca
     1861 gtagatgatt ttcaaatttt ctttactata gtagccttga ccagaaataa aagtaacacc
     1921 tcttccgagg tcatcattaa tcgccttagc aagttggtca ggacgttttg tgataatcat
     1981 aaagcctttg ccggcatatc ctccttcacc aatcaaatca ataacacgag aaacaataaa
     2041 atcaaacaaa agcgtgtagg aaaccaatct caaatccttg aagattagga gaatcaacat
     2101 gagaatacaa aaatctaaga taaagagcag ttttcctatg gatatatgag tgtatttgtt
     2161 gagaatacga gctagaatat cagttccgcc agttgtacct ccagcattaa aaataattcc
     2221 aaggccaatt cccaatagga ttcccgctat aagggctgtg attagtaaat caccttgaag
     2281 atcaatatga aggggaatat gctcaaaaaa agctaaccag ccggacaaag ctaaggttcc
     2341 tagtaaacta gaatagaggg atttggctcc aaaaatcttc caagctagga tgaaaagggg
     2401 aatattaatc agcaggttca tgagggaaac agggatttta aaaagataaa aggtgatgag
     2461 ggtaatgcct gtcgcccctc cttcaaagag atgatgggga actacaaaat aagtcagtcc
     2521 aaaagcataa atagcagcac ctagtaaaat ggtaaaaatg gggtaaattt ttttaatcat
     2581 aggacacctc ttttcttata agttgattat atcaaatttt acggaaa
//
LOCUS       DAVLHC010000110         2594 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.111, whole genome shotgun sequence.
ACCESSION   DAVLHC010000110 DAVLHC010000000
VERSION     DAVLHC010000110.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2594)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2594)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2594
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.111"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..555
                     /locus_tag="VXE25_002140"
     CDS             <1..555
                     /locus_tag="VXE25_002140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001003686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HEV0772524.1"
                     /translation="YKYDFFNYTMIPFVEKYTNLIVCSSISKSLCAPGLRIGYICANE
                     KIVKKLEKKVIPFNVSNINQCIAEKILENFPLSLSICSDIESSFRQLDLFMEKYTTQK
                     SEKACGFRLYQLKAKYDGNKIIDILTERGFLIRNISASYPELGENWIRISNGTLSEIK
                     DLMHIMKDIFEDFDDKASDSYDKG"
     gene            598..1956
                     /locus_tag="VXE25_002141"
     CDS             598..1956
                     /locus_tag="VXE25_002141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001852388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772525.1"
                     /translation="MKLSSDLNILIRQLSYFIKDKEMLQQKIFGNFLDRFEEAYEQHF
                     FDIFDSLTGGIKISDVDWILGEEKLIKFLGRKNKNGQYLYVLPTNDGYLLRGSETYYH
                     YLSNVPYDYFKLIDKNIFIDGLKSTQNFLTEFIQYINSENSLTLKISLAFLDNLRNQI
                     LILLNAKFLVENDFKHGKYYVNFDSKLFKAIELFYSYYEKLFNFKHFILQPEDLVVIL
                     DILNSEIEALIPKLKNLDNNKVRKLTRVFRELDSIWEIFISLKYFFESENSLDVDNIS
                     EFCGIAYGGIEIPLVAHLFKEKNEISFLFQNSHYSTQEVEVKRFRDSRRNDSKSILLM
                     DDNILTGRAMKNAAQKLSYRKYSVQFFHVRRLGLNRLSQVIQENSMNELQRYLTGIYK
                     GGIFPAPYSKIKFGTNIAKQYLDELQIFTLSGDEILRLLYKNGLFSEESEVKVVRGNL
                     YE"
     gene            1953..2588
                     /locus_tag="VXE25_002142"
     CDS             1953..2588
                     /locus_tag="VXE25_002142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000143825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chloramphenicol acetyltransferase"
                     /protein_id="HEV0772526.1"
                     /translation="MTFPISEWKRNEEFDFFNKMDVPYLSMSSRIEVTQAINFHKKHS
                     ISLYAIISWCVMSAINSIPELLMDTDGKIVWQYNQRGCSFTTLTSEDKLNFSSFTMGD
                     NLIEFVSAFNINKQKAEEGQKPNIDKNNIAYLSCVPWIDFLHVSTPMNLSKIDTVPRI
                     TWGKVIQENQRYFCTVNLQINHGMGDGLHVSNFFVLLQRFVNKINEYFQKK"
BASE COUNT          951 a          309 c          453 g          881 t
ORIGIN      
        1 tataaatatg atttttttaa ttatacaatg ataccatttg tagaaaaata tactaatttg
       61 attgtttgtt cctcaatatc gaagtcacta tgtgctcctg gattaagaat aggctatata
      121 tgtgctaacg aaaaaattgt aaaaaaatta gaaaaaaaag taattccttt caatgtttct
      181 aatatcaatc aatgtatagc tgaaaaaata ttagaaaatt ttccgctctc tctaagtata
      241 tgttcagaca ttgagtcttc atttagacaa ttagatttat ttatggagaa atacactact
      301 caaaagtctg aaaaggcgtg tggtttcagg ttataccagt tgaaagcaaa atatgatggt
      361 aataaaataa tagatatact aacggaaaga ggttttttga taagaaatat aagtgcttca
      421 tatcctgaat tgggtgaaaa ttggataagg attagtaatg gcacgttatc agagattaaa
      481 gatttgatgc acataatgaa agatatcttt gaagattttg atgacaaagc cagtgatagt
      541 tatgacaagg ggtaggtgtt gaaaataaaa gatagtgcgg agattttgaa taataatatg
      601 aaattaagta gtgacttaaa tattttaata aggcaactct cttattttat aaaagacaag
      661 gaaatgttgc aacaaaagat ttttggtaat ttcttagata gatttgaaga ggcttatgag
      721 cagcactttt ttgatatttt tgattcactt actgggggaa ttaagattag tgatgttgat
      781 tggattttag gtgaagaaaa gttgattaaa tttcttggga gaaaaaataa aaatggtcaa
      841 tacctctacg tacttccaac aaatgacggc tatttactca gaggttctga aacatactac
      901 cattatttat cgaatgtacc atatgattat tttaaactca ttgacaaaaa tatatttatc
      961 gatggcttga aatctacaca aaatttttta acggaattca tccaatatat aaattcagaa
     1021 aactctttga ctcttaaaat cagtcttgca tttctagaca atttaagaaa tcaaatttta
     1081 atactcttga atgctaagtt tttagtagag aatgatttta aacatgggaa atattatgtg
     1141 aatttcgatt ctaaactatt caaagctatt gagttatttt acagctatta tgaaaagcta
     1201 tttaatttca agcattttat tctgcaaccg gaagatttag ttgtgatcct tgatatttta
     1261 aactctgaaa ttgaagcttt gattcctaag cttaaaaatc tagataataa taaagttaga
     1321 aagcttactc gtgtttttag ggaattagat tctatctggg aaatttttat ttctttaaag
     1381 tatttctttg aaagtgaaaa ttcattggat gtagataata ttagtgaatt ttgtgggata
     1441 gcttatggcg ggatagaaat tcccttggtt gcgcacctat ttaaagaaaa aaatgaaata
     1501 tcatttttat ttcaaaatag ccactacagt actcaagaag ttgaagtaaa aaggttcagg
     1561 gacagtcgga gaaatgattc gaaaagtatc ttattaatgg atgataatat tttgacagga
     1621 agggctatga aaaatgctgc tcagaaatta tcataccgaa aatattcagt ccaattcttt
     1681 catgtcagga ggcttggcct aaatagatta tcacaagtta ttcaagaaaa ttcaatgaat
     1741 gaattgcaga ggtatttaac aggaatatat aaaggaggga tttttcctgc accgtattca
     1801 aaaattaaat tcggtactaa tattgctaaa caatatttag atgaattaca aatttttact
     1861 ctatctggag atgaaatctt aagactactt tataagaatg gcttgttctc agaagagagt
     1921 gaagtgaaag tggtaagggg gaatttatac gaatgacatt tcctatatca gagtggaaaa
     1981 ggaatgaaga atttgacttt ttcaataaaa tggatgttcc ttatttatct atgagttcac
     2041 gaatagaagt aacgcaggct atcaattttc ataaaaaaca ttcgatatca ctttatgcca
     2101 taatatcgtg gtgtgttatg agtgcaataa attctattcc agaattacta atggataccg
     2161 acggaaagat tgtctggcaa tacaatcaaa gaggttgttc tttcactacc cttacatcgg
     2221 aagataagct taatttttct tcatttacga tgggagataa tttaattgaa tttgtttctg
     2281 cgttcaacat aaataaacag aaggcagaag aagggcaaaa accaaatatt gacaagaata
     2341 acattgctta tctttcttgt gttccatgga ttgatttttt acatgtaagc actcctatga
     2401 atctttcaaa aattgataca gttcctcgaa taacgtgggg aaaagttatt caagagaacc
     2461 aaagatattt ttgtacagtg aatttacaaa ttaatcatgg aatgggagat ggattacacg
     2521 tatctaattt ttttgtgtta ttgcaaaggt ttgtaaataa aataaatgaa tattttcaaa
     2581 aaaagtaatg attg
//
LOCUS       DAVLHC010000111         2586 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.112, whole genome shotgun sequence.
ACCESSION   DAVLHC010000111 DAVLHC010000000
VERSION     DAVLHC010000111.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2586)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2586)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2586
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.112"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            272..646
                     /locus_tag="VXE25_002143"
     CDS             272..646
                     /locus_tag="VXE25_002143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424474.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPH_0224 family bacteriocin-like peptide"
                     /protein_id="HEV0772527.1"
                     /translation="MELVLPNNYVVLEQEEMMYLDGGFSIPRWPVATAINIAFNGVLG
                     GGAISLVRNYIRNYGLRRVTSAIAGAAARYVGVRVANRVAGFALPAINGFAAWMSIGD
                     AITTIWANNDVNRRDPNLNALW"
     gene            854..1756
                     /locus_tag="VXE25_002144"
     CDS             854..1756
                     /locus_tag="VXE25_002144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772528.1"
                     /translation="MIRKLIVFLLMLPLFVLWLELHVLVNNLLLNLESPLDFVISMSL
                     AFCSLILSKIVLDILYALKDLYKKEGLIKIFPFIFIRRKKVNVRFSPYFSFHRKSLSP
                     DDLRSRIIWSFILEIAIILVFILKIPFAIIMLTTIFFWTIMDINHLVFNKTEFLFNQN
                     KWEKEDSFESDLTNTLKDKIQKSDLSYSDLMSLQLYDAMNQSTFLTDSELFEDILSKI
                     EDSHNTLLCTGLVELLLYEISISNNNNWQEKVDKIRIQLIRINQLDFFYYTSWLRQNF
                     DFCMNREYHKMKSRKLLLSNKKIV"
     gene            1812..2165
                     /locus_tag="VXE25_002145"
     CDS             1812..2165
                     /locus_tag="VXE25_002145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="argininosuccinate lyase"
                     /protein_id="HEV0772529.1"
                     /translation="MDLVLPNNYVVIDEEEMMYLDGGAYLSKRACQGICAALAMSSGT
                     FIALAGAAVLTKKLINYIKVGGLGGWLIGAAAGVLATAAGKIAYCIGYGVLNRGCDIN
                     GNPYPWDGFISATVR"
     gene            2162..>2586
                     /locus_tag="VXE25_002146"
     CDS             2162..>2586
                     /locus_tag="VXE25_002146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772530.1"
                     /translation="MSNVDKIRKIHIIVCWVYIFLSFRAIINDTEYFLLIFLAFIYSI
                     VSLPLYSVKNKIVSICLAINSILLMSFPILINKFFPESFLTYTVLISVFILELAIFHL
                     IGEDFATKLTNEYKKISQFRSKVSQSPWIKYLEISSFILT"
BASE COUNT          853 a          334 c          480 g          919 t
ORIGIN      
        1 tatattaggt gtattgctaa ttggaattgc gttactaagt caaaaaaaat aaattttgaa
       61 atagtattag tgagttcgca atcatttatt gctagtggtt tagaactgtt aagtttcaaa
      121 caataattga ttttaaacct taggtaacct ataaaaacaa ataaggtaga gaaaggatat
      181 cttatctagg tagctaagtg ataaaaacac agtcgtctat cacttgttag gaaactatcc
      241 taactatgct taataaaaaa ggagaaaata aatggaactc gtattaccaa ataattatgt
      301 tgttcttgag caagaagaga tgatgtatct tgatggggga ttttctattc cgagatggcc
      361 tgttgcaaca gccattaata tagcttttaa tggtgtttta ggtggaggag caatcagtct
      421 agttagaaat tatattcgta attatggttt gcggcgagtt acaagcgcaa ttgctggagc
      481 agctgcaaga tatgttgggg tacgagttgc aaatagagtg gcaggatttg cactgcctgc
      541 tattaatgga tttgcagctt ggatgtcaat tggcgatgct attacaacaa tctgggccaa
      601 taatgatgta aataggagag acccaaattt aaacgccttg tggtaactag atatgggtat
      661 taaaatggaa aaaatttttg ttattatttt ttttgtatgt ctatttatat catccataac
      721 ttttttagcc tatgattttg ttagcgaaga aataaaaaag ttgattattt ggattaatgt
      781 cgtttttttg attttaatca tagcaatgat gatttatcca aaattaagaa aatgataagg
      841 acactgtaaa attatgatac gtaaactaat tgttttctta ctaatgctcc ctctttttgt
      901 cttgtggcta gagttgcatg tcctagtgaa taacttacta ttgaatctag aatctcccct
      961 tgattttgtg attagtatga gtcttgcttt ctgtagtttg attttatcaa aaatagtttt
     1021 agacatacta tacgcattga aagatttata caagaaagaa ggtcttatta agatttttcc
     1081 ctttattttt ataagaagga aaaaagtgaa tgtgagattc tcgccctatt tttcattcca
     1141 tcgtaaaagt ttgtcgcctg atgatttaag atctaggatt atatggagtt ttattcttga
     1201 aattgctatt atcctagtat ttattttaaa aattcctttt gcaatcatca tgcttactac
     1261 aatatttttc tggactataa tggatatcaa tcatctcgtt tttaataaga cggaatttct
     1321 tttcaatcaa aataaatggg aaaaagaaga ttcgtttgaa agtgatttga caaatacgtt
     1381 aaaggataaa atacaaaaat cagatctcag ttattctgac ttaatgtctc ttcagctgta
     1441 tgatgcgatg aaccaatcca cctttttaac ggatagtgaa ctctttgagg atattctgag
     1501 taaaattgaa gattctcata acacccttct gtgtacaggt cttgtcgagt tactgctgta
     1561 tgagatttct attagtaaca ataacaactg gcaagaaaag gttgataaaa ttagaataca
     1621 gctcatcaga ataaatcaat tagatttttt ctattataca agttggttaa ggcaaaattt
     1681 tgatttctgt atgaatagag agtatcataa aatgaaatct cggaaattat tactgagtaa
     1741 taaaaagata gtttaagttc gtcctatttg taaaacaaat gaaacaattt caactaagga
     1801 ggagaaaact tatggactta gtattaccaa ataattatgt tgtgattgat gaagaagaaa
     1861 tgatgtatct tgatggggga gcttatttaa gcaagcgtgc ttgtcaagga atttgcgcag
     1921 ctttagctat gagttcagga acttttatag cattagctgg agctgcagtt ttaaccaaaa
     1981 aactaataaa ctatattaag gttggaggtc ttggaggctg gcttattggt gcagcagcag
     2041 gtgtattggc tacagcagca gggaaaatag cttactgtat tggatatggt gttcttaata
     2101 gaggttgtga tattaacggg aacccttatc cttgggatgg attcatatct gcaacagtaa
     2161 gatgagtaat gtagataaga ttcgaaaaat acacatcatc gtgtgttggg tgtatatatt
     2221 tttatcattc agggcgatta taaatgatac ggagtatttt ttgcttattt ttttagcttt
     2281 tatctactca atagtatcac tacctctata ttctgtgaaa aataaaatag tatctatctg
     2341 tctagccata aattcgattc tgttaatgag tttccccatt ttaatcaata agtttttccc
     2401 agaaagtttt ttgacttata ccgtattaat aagtgttttt atcctagagt tagcaatctt
     2461 tcatttaatt ggggaagatt ttgctactaa attgactaac gaatataaga aaattagtca
     2521 gtttagaagc aaggtgtctc aatctccttg gataaaatat ttagagattt ctagttttat
     2581 attaac
//
LOCUS       DAVLHC010000112         2454 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.113, whole genome shotgun sequence.
ACCESSION   DAVLHC010000112 DAVLHC010000000
VERSION     DAVLHC010000112.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2454)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2454)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2454
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.113"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..204
                     /locus_tag="VXE25_002147"
     CDS             <1..204
                     /locus_tag="VXE25_002147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000756162.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HEV0772531.1"
                     /translation="SRVISGSAQPQLPITKLKKILLPLPPLALQNEFADFVAQVDKSQ
                     LAIQKSLEELETLKKSLMQEYFG"
     gene            264..500
                     /locus_tag="VXE25_002148"
     CDS             264..500
                     /locus_tag="VXE25_002148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000260605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AbrB family transcriptional regulator"
                     /protein_id="HEV0772532.1"
                     /translation="MVVKTRKQGNSITITIPSEFNIPSGVKYEAKLLPSGEIIFTPEE
                     LGQQVSYVSDDAFDLNLDKIFDEYDDVFKALVEK"
     gene            497..910
                     /locus_tag="VXE25_002149"
     CDS             497..910
                     /locus_tag="VXE25_002149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000158364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system death-on-curing
                     family toxin"
                     /protein_id="HEV0772533.1"
                     /translation="MTIYLTEKQIEKINALAIQRYSPNEKIQTVSSSALNMIVNLPEQ
                     FVFGKSLYPTIFDKATILFVQLIKKHVFANANKRTAFFVLVKFLQLNGYRFSVTVEEA
                     VKMCVTIAVEALTDEKMTSYSKWVSEHSVREKVKK"
     gene            1028..1993
                     /locus_tag="VXE25_002150"
     CDS             1028..1993
                     /locus_tag="VXE25_002150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000444451.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HEV0772534.1"
                     /translation="MESKVTIIMQEMLPLLNNEQLLALRESLEHHLVDGKKQQKYSNN
                     NLLQLFITAKQVEGCSSKTIRYYQRTIENLFNAIKESVTQLTTDDLRSYLANYQSEKD
                     CSKANLDNIRRILSSFFAWLEQEEYIIKNPIRRIKKIKTEQNVKETYTDEHLEIMRDN
                     CENLRDLAIIDLLASTGMRVGELVQLNRSDIDFENRECVVFGKGKKERPVYFDARTKI
                     HLRNYLNDRKDSHPALFVTLVGKVQRLGIAGVEIRLRKLGDKLGIQKVHPHKFRRTLA
                     TKAIDKGMPIEQVQKLLGHSKIDTTLAYAMVNQNNVKHSHQKFIS"
     gene            1959..>2454
                     /locus_tag="VXE25_002151"
     CDS             1959..>2454
                     /locus_tag="VXE25_002151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001821324.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HEV0772535.1"
                     /translation="MSSIHTKNSSLKSKSRFNEMFGDVILNEKEWKVSKWNEILTIRN
                     GKNQKQVEDADGKFPIYGSGGIMGYAKDWIVKKNSVIIGRKGNINKPILVRENFWNVD
                     TAFGLEPVLEKINSEYLFYFCQLYNFEKLNKAVTIPSLTKSDLLNISIPLPPLALQNE
                     FADFV"
BASE COUNT          897 a          369 c          472 g          716 t
ORIGIN      
        1 agtcgagtga tatcaggaag tgctcagcct cagttaccaa ttacaaaatt aaaaaaaata
       61 cttctccccc tccccccact agccctccaa aatgagttcg cagactttgt agcccaggtc
      121 gacaaatcac aattggcaat ccaaaaatct ctggaagaac ttgaaacttt gaagaaatct
      181 ctgatgcagg agtattttgg ctgatattct gccattgtaa ttacggtaat gatttgttat
      241 aatacttcaa aggaggaaat cagatggtag taaaaacaag aaaacaagga aattcaatca
      301 ccattacgat tccaagtgaa tttaatattc caagtggtgt taaatacgaa gcgaaattgt
      361 taccaagtgg tgagattatc tttactcctg aagaattggg gcagcaggtt tcttatgtat
      421 ctgatgatgc ctttgactta aatttagata aaatatttga cgaatacgac gatgttttca
      481 aagctttggt ggaaaaatga caatctatct gacagaaaag caaattgaaa aaataaatgc
      541 tttagcaatt caacggtatt ctccaaatga gaaaattcaa acagttagtt cttctgcctt
      601 aaatatgatt gtgaacttac cagaacaatt tgtctttggg aagtctcttt atccaacaat
      661 ttttgataaa gcaacgatac tatttgtcca attgataaag aagcatgttt ttgctaatgc
      721 taataaaaga actgctttct tcgttttggt caaattttta caattaaacg gctatcgttt
      781 ttctgtaacg gtagaagaag cagtaaaaat gtgtgtaacc atcgcagtag aagctttaac
      841 tgatgaaaaa atgacaagct actccaaatg ggtttctgaa cattctgtta gagaaaaggt
      901 caaaaagtaa cctagtatgc tggatttgaa tgagcacaag aaaataaatg aacagacaat
      961 attagaattc tgtaatgcag aaactgatat tgtctctttt tattgatgaa taagaaagtg
     1021 agaaattatg gaatcaaaag ttacaattat catgcaagaa atgttacctc ttttaaataa
     1081 tgaacaatta ctagcgttga gagagagttt agaacatcat ctagtagacg gaaaaaagca
     1141 gcagaagtat tcgaataata acctgttgca actatttatt accgccaagc aggtagaggg
     1201 ctgtagctca aaaacaattc gttattacca gaggacgatt gaaaacttgt ttaatgctat
     1261 taaagagtct gtgacacaac tcacaacaga tgatttaagg agttatttag caaattacca
     1321 gtctgaaaag gattgtagta aggcaaattt agacaatatt aggcgtatat tgtcttcttt
     1381 ttttgcttgg cttgagcaag aggaatatat cattaaaaat cccattcgac ggataaagaa
     1441 aattaagact gagcaaaatg tgaaggaaac ttatactgat gaacatttgg aaattatgcg
     1501 tgataactgt gaaaatttga gagatttggc aataatagac ctactagcat cgacaggtat
     1561 gcgtgtaggg gagcttgtac agttgaatcg ttcagatatt gattttgaaa acagagagtg
     1621 tgttgtcttt ggtaaaggaa agaaggagag accagtatat tttgacgctc ggacgaaaat
     1681 tcatttaaga aattatctta acgacagaaa agatagtcac cctgctcttt ttgtaacgtt
     1741 agttggaaaa gtccagaggc ttggaattgc tggtgtagag attcgcttaa gaaagttagg
     1801 agacaaactc ggtatacaaa aggttcaccc acataagttc agaagaactt tagcgactaa
     1861 ggcaattgat aaaggtatgc ctatcgaaca agtccaaaaa ctgctaggtc atagcaagat
     1921 tgacacaacc ctggcctatg ccatggtcaa tcaaaataat gtcaagcatt cacaccaaaa
     1981 attcatctct taaaagcaaa tcccgattta acgagatgtt tggggatgtt attctaaatg
     2041 aaaaagaatg gaaagttagc aaatggaacg agattctaac aataagaaat ggtaaaaatc
     2101 aaaaacaggt tgaagatgct gatgggaaat ttcctattta tggaagtggg ggaattatgg
     2161 gatatgctaa agattggata gtgaagaaaa attcagttat tattggacgt aaaggaaata
     2221 taaataaacc tattttagtt agagaaaatt tttggaatgt agatacagca tttggattag
     2281 agcctgtttt agaaaaaata aactcagaat atttattcta tttttgtcaa ttatacaatt
     2341 ttgagaagtt aaataaggct gtaacaatac ctagtttaac taaatcagat ttattaaata
     2401 tttccatccc cctcccccca ctagccctcc aaaatgagtt cgcagacttt gtag
//
LOCUS       DAVLHC010000113         2437 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.114, whole genome shotgun sequence.
ACCESSION   DAVLHC010000113 DAVLHC010000000
VERSION     DAVLHC010000113.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2437)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2437)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2437
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.114"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            114..536
                     /locus_tag="VXE25_002152"
                     /pseudo
     CDS             114..536
                     /locus_tag="VXE25_002152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001211071.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
     gene            complement(748..1140)
                     /gene="rpsI"
                     /locus_tag="VXE25_002153"
     CDS             complement(748..1140)
                     /gene="rpsI"
                     /locus_tag="VXE25_002153"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002942223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S9"
                     /protein_id="HEV0772536.1"
                     /translation="MSQAQYAGTGRRKNAVARVRLVPGTGKITVNKKDVEEYIPHADL
                     RLVINQPFAVTSTVGSYDVFVNVVGGGYAGQSGAIRHGIARALLQVDPDFRDSLKRAG
                     LLTRDSRKVERKKPGLKKARKASQFSKR"
     gene            complement(1159..1605)
                     /gene="rplM"
                     /locus_tag="VXE25_002154"
     CDS             complement(1159..1605)
                     /gene="rplM"
                     /locus_tag="VXE25_002154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003083327.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L13"
                     /protein_id="HEV0772537.1"
                     /translation="MNKTTFMAKPGQVERKWYVVDATDVPLGRLSAVVASVLRGKNKP
                     TFTPHTDTGDFVIVINAEKVKLTGKKATDKIYYTHSNHPGGLKQISAGELRSKNAVRL
                     IEKSVKGMLPHNTLGRAQGMKLKVFVGAEHTHAAQQPEVLDISGLI"
     gene            1962..2279
                     /locus_tag="VXE25_002155"
     CDS             1962..2279
                     /locus_tag="VXE25_002155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF960 domain-containing protein"
                     /protein_id="HEV0772538.1"
                     /translation="MAFTNTHMRSASFGIVTSLPDDIIDSFWYIIDHFLKNVFELEEE
                     LEFQLLNNQGKITFHFSSQHLPTAIDFDFNHPFDPRYPPRVLVLDMDGRETILLPEEN
                     DLF"
BASE COUNT          748 a          472 c          444 g          773 t
ORIGIN      
        1 aagaaaatta agataaaact aaaaggactt agtcctgtgc aatacagaac taaatccttc
       61 ggataaatta attgtctaac tttttggggg cagtacataa gaaccttggt aatatgcgtt
      121 ttattatggc aacatttccc attttctcta tttctaatga cttacttcaa ctccttacct
      181 cttggaaaga acaacaaaga tatgaactag caaagtttgg catcctcagt aatccagaac
      241 aatttgtttt tacatatatc gacacaaaag gaaacatcaa caagccttta catgccgact
      301 atctgaacaa taaaatgaaa agcattagaa agcgacataa agaactgaca cacgctacac
      361 ctcacaaatt acgccataca ggcgcaactc tagctaaata agcaggaatg agcttagaag
      421 ccatttctga agcactaacg catagcgata caggcacaac tcaaatttat gtcaacacct
      481 ctaatgtagt tcctatgaca gtaggtgaat ttgctttaaa gtctctaaaa caataaggta
      541 tagtagattg aaactagaat agtacacctc tacttctaaa acattgttag aattcgattt
      601 gactgtcctg atcgatttgt cctattctta tttcatttcg ctataaaaat aaggtaaact
      661 ttgagataaa cttttcaaaa aaacacgaaa aaagcaccca taaggtaaac ttttgagtgc
      721 tttgaaacgt tgatataatc gtattgatta acgtttacta aattgtgatg ctttacgagc
      781 tttcttaaga cctggtttct tacgttcaac tttacgtgag tcacgtgtaa gaagtcctgc
      841 gcgtttcaat gaatcgcgga agtctgggtc tacttgaaga agggcacgag cgataccgtg
      901 acggatagct cctgattgac cagcgtatcc accacctaca acgttaacga aaacgtcgta
      961 tgaacctaca gttgaagtaa ctgcgaatgg ttggttgatg acaagacgaa ggtcagcgtg
     1021 tgggatgtac tcttcaacat cttttttgtt aacagtgatt ttaccagttc ctggaacaag
     1081 gcgaacgcgt gcaacagcgt ttttacgacg tccagtacct gcatattgtg cttgtgacat
     1141 actttattgt tcctttcctt agataagtcc tgaaatgtca agaacttctg gttgttgtgc
     1201 agcgtgagtg tgctcagctc caacaaatac tttcaacttc ataccttgag cgcgtccaag
     1261 tgtattgtgt ggaagcatac ctttaactga tttctcaatc aaacgtactg catttttaga
     1321 acgaagttca cctgcagaga tttgtttcaa tccacctggg tggtttgagt gagtgtagta
     1381 gattttatca gttgcttttt taccagtcaa tttaactttt tcagcattga taacaatcac
     1441 gaagtcacct gtatcagtgt gtggtgtaaa tgttggtttg ttttttccgc gaagtacgct
     1501 agcaactact gcagaaagac gtccaagtgg tacatcagtt gcgtcaacta cgtaccattt
     1561 acgttcaact tggcctggtt tagccataaa tgttgttttg ttcatgattt ctcctatata
     1621 tagttcgatt tttgtttacg gtgatgggtg ttccttccca tcgaaaagta tttggaaggt
     1681 tccggggcct ttcaaatggg gtaaacaata ccgcctacta tcataccaaa tttcacccct
     1741 aaaagtcaat agatatgaaa aatatttttc ggtaacttct caaagtaact gaaagttata
     1801 taatcaagtt aatttgggaa tttacctatt aacttcggta gatttttgag aatttttttc
     1861 cttctttttc cttgtagtta aaatcctttt caaaaaatca ccttttcttg atttttaatc
     1921 ctatttgctg tatgataagg gaaaagaaag gggacagaga tatggctttt accaataccc
     1981 acatgcgatc tgctagtttt ggcattgtta ccagcttgcc tgatgacatc attgactctt
     2041 tttggtatat tatcgaccat ttcttaaaaa atgtctttga attggaagaa gaactcgagt
     2101 ttcaattgct taataaccaa ggaaagatta ccttccactt ttcaagtcaa cacctcccta
     2161 cagccattga ttttgacttt aaccatcctt tcgaccctcg ttatccccca agagtactgg
     2221 ttttagacat ggacggtaga gaaactatcc tcctcccaga agaaaatgac ctattttaat
     2281 acttaatgaa aatcaaagag caaactagga agctagccgc aagctgtact tgagtacggt
     2341 aaggcgacgc tgacgtggtt tgaagagatt ttcgaagagt ataaaaactc tagccttcag
     2401 ttgcaagtaa ctgaaaacta gagtttttct atttttt
//
LOCUS       DAVLHC010000114         2311 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.115, whole genome shotgun sequence.
ACCESSION   DAVLHC010000114 DAVLHC010000000
VERSION     DAVLHC010000114.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2311)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2311)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2311
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.115"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..155
                     /locus_tag="VXE25_002156"
     CDS             <1..155
                     /locus_tag="VXE25_002156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001021237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="HAD family phosphatase"
                     /protein_id="HEV0772539.1"
                     /translation="LVNKYQLDIKDCIFLDDLEENVEAARTLGIKAFQIKERKEISNI
                     LKDLLN"
     gene            165..2192
                     /locus_tag="VXE25_002157"
     CDS             165..2192
                     /locus_tag="VXE25_002157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000256298.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HEV0772540.1"
                     /translation="MVTIKDIARVSGVSHGTVSNVLNKKGNVSAAKIKLVEETAKKLG
                     YNMNSQAQFLRKGASSKCFFLLFNNARKKYAEYFAEIDQLSLDVEYVYLHKFSEIKNK
                     ISAILSENPQFIVCLGFSPKRFVDIEDNIPIFEVDTYQSNKTLSSFDSDKIFEIVLEL
                     VRTEKLSNLYFISLTNEKEHSLFEYLTQKIKNSTHIQVQERLQLLSLYPTLKNFAKYD
                     CIFVDDEDLMHTLLDLFDWFTIIDRPKICLIGSRVWFEKRNLFYIHLDYRILALNTAE
                     NLESGNSSIVPVKDGKQILTNQLFDGECDDIYLLTVHSPMNKALEILSEKYKQISGKN
                     IKIIEKRYDELLEMIESGDVSSSFDMIRMDMAWLPTFGKKYFQEITSFRQTKSINQNI
                     SKSVSREYMYIDQKQYTFPLDVSSQILVYRKDLFEDSFLQRRYFEKTKRKLTVPKSYQ
                     EFDELSEFFTLTENPFSPTLYGHSLALSSSVRAACEFIPRFRERLAQSRMNLAVLPQV
                     LTEYEKSYQFTEKSFNSSWNDFVTNLNSGKTSMEIIFSNYTSPLFDGLNVSAQFEFAT
                     ATIPGNTPVIGGGSIGISKYSNRVEECLNFINWLYSEEISILLTSLGGFLPSKYVMQN
                     RMLQFQYPWLSSLEDTFSIGSRTKWYGFNTDFRFEQMLGQELIESVKHRYG"
BASE COUNT          832 a          276 c          381 g          822 t
ORIGIN      
        1 cattagttaa taaatatcaa ttagatataa aagattgtat atttttagat gatttagaag
       61 aaaatgtaga agctgcaaga actctaggta ttaaagcatt tcaaattaaa gagcgtaaag
      121 agatctcaaa tatactaaaa gatctcttaa actagaggtt aattatggtt acaataaaag
      181 atattgcaag agtgtctgga gtctcacatg ggacagtttc aaacgtttta aataaaaaag
      241 gtaatgtctc agcagctaaa ataaagttag tagaagagac tgcgaaaaaa ttgggttata
      301 atatgaattc tcaagctcag tttcttcgaa aaggcgcttc tagtaaatgt tttttcttgt
      361 tatttaataa tgcacgcaaa aagtatgctg agtattttgc agaaattgat cagttatctt
      421 tagatgtaga atatgtttac ttacataaat tctcagagat taaaaataag atatctgcaa
      481 ttttaagtga aaatcctcaa tttatagttt gcttaggttt ttctccaaaa agattcgttg
      541 atattgaaga taatattccg atttttgaag tagatacata tcaatctaat aaaactttat
      601 cttcctttga tagtgataaa atatttgaga ttgtacttga gttggttcgg actgaaaagc
      661 tatctaattt atattttatt tcacttacta atgaaaaaga acattcttta tttgaatatt
      721 tgactcaaaa aataaaaaac tcaactcata tacaagtgca agaacgttta caattgttgt
      781 ctctatatcc tactctaaaa aactttgcaa agtatgattg tatatttgtt gatgatgaag
      841 atttgatgca cacgctatta gacttatttg attggtttac tataattgat agaccaaaaa
      901 tatgtttgat aggttcacgt gtttggttcg aaaaaagaaa tcttttttat atacatttag
      961 attatagaat attggcactc aatactgccg aaaatttaga aagtggaaat agttcaattg
     1021 taccagttaa agatggcaaa caaattttaa ctaatcaatt atttgatgga gaatgtgatg
     1081 atatttattt acttactgtc cattcaccaa tgaataaagc cttagaaatt ttatcagaaa
     1141 agtataaaca aatttctggg aaaaatatta aaattatcga gaaaagatat gatgaacttt
     1201 tggagatgat tgagtctggc gatgtttcat ccagttttga tatgattaga atggatatgg
     1261 cttggcttcc aacatttggg aaaaagtatt ttcaagagat tacaagcttt agacaaacaa
     1321 aaagtattaa tcaaaatatt tctaagtcgg tgtctcgaga gtatatgtat attgatcaga
     1381 agcaatatac ttttccattg gatgttagta gtcagatttt agtatataga aaagacttat
     1441 ttgaagattc atttttacaa agacgatact ttgaaaaaac aaaaagaaaa ttaactgtac
     1501 caaaaagtta tcaagagttt gatgagttaa gtgaattttt tacattaaca gaaaatccat
     1561 tttcacctac actttatggc catagtttag ctttaagttc ttcagtgaga gcagcatgtg
     1621 aatttattcc tcggtttcgt gagagattag cacaatctag aatgaatctt gctgtacttc
     1681 ctcaggtttt aactgagtat gagaaaagtt atcagtttac cgaaaaatca tttaattctt
     1741 cgtggaacga tttcgttacg aacttaaaca gtggtaaaac ttcaatggaa ataatttttt
     1801 caaattatac tagtccatta tttgatggtc tcaatgtttc tgctcagttt gagtttgcaa
     1861 ctgccactat acctggtaat actcctgtga taggtggtgg ctcaattgga atttctaaat
     1921 attcaaatag agtggaagaa tgtctaaact ttattaattg gttatattct gaagagattt
     1981 ctattttact aacatctctg ggtggttttt taccatcaaa gtatgtcatg caaaatagga
     2041 tgttacaatt tcaataccca tggttatcta gtttagaaga tacatttagt attgggagta
     2101 gaacaaaatg gtacggcttt aatactgatt ttagatttga gcagatgtta gggcaagagt
     2161 taatagaaag tgtgaagcat agatatggat aaattaatac taaattttta ttactagttt
     2221 atttattatt gtttaaaatt aaagattcaa gtaaacacca attatattta aaattattat
     2281 tttgacattt ttctattgca aagttatttt a
//
LOCUS       DAVLHC010000115         2188 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.116, whole genome shotgun sequence.
ACCESSION   DAVLHC010000115 DAVLHC010000000
VERSION     DAVLHC010000115.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2188)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2188)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2188
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.116"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..278
                     /gene="tnpB"
                     /locus_tag="VXE25_002158"
     CDS             <1..278
                     /gene="tnpB"
                     /locus_tag="VXE25_002158"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="IS66 family insertion sequence element accessory
                     protein TnpB"
                     /protein_id="HEV0772541.1"
                     /translation="KTDMRQGIDSLAYLVKTHFELDPFSGQVFLFCGGRKDRFKALYW
                     DGQGFWLLYKRFENGRLTWPSTEKDVKALAPEQVDWLMKGFSITPKI"
     gene            475..669
                     /locus_tag="VXE25_002159"
     CDS             475..669
                     /locus_tag="VXE25_002159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEV0772542.1"
                     /translation="MKIIQQQSATIDSLTNELALLREQVAYLTQKLYGKSSEKSVCPS
                     GQLNLFEEESPSEEDGDVPS"
     gene            656..961
                     /locus_tag="VXE25_002160"
     CDS             656..961
                     /locus_tag="VXE25_002160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000484476.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family transposase zinc-finger binding
                     domain-containing protein"
                     /protein_id="HEV0772543.1"
                     /translation="MFPVETEEITYKRKKSKGKRQALLAQFDSEEVHHQVEERICPDC
                     QGDLKEIGGSLQGQELVFIPAQLKRIDHIQHAYKCQACSDKNPSDKIVKAPIPKAPL"
     gene            977..1183
                     /locus_tag="VXE25_002161"
                     /pseudo
     CDS             977..1183
                     /locus_tag="VXE25_002161"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001827253.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            1256..1705
                     /locus_tag="VXE25_002162"
     CDS             1256..1705
                     /locus_tag="VXE25_002162"
                     /inference="COORDINATES: protein motif:HMM:NF015038.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEV0772544.1"
                     /translation="MVNCEQLEAYRQLEEAALVGCWAHVRRKFFEVPPKQADKSSLGA
                     KDLAYCDQLFSLERDWEALPADERLQKRQEHLQPLLEDFFAWCRRQSVLSGSKLGRAI
                     EYSLKYEETFKTILKDGHLVLSNNLAERAIKSLVMGRSKRVQWTLLA"
     gene            1777..1935
                     /locus_tag="VXE25_002163"
     CDS             1777..1935
                     /locus_tag="VXE25_002163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931950.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase domain-containing protein"
                     /protein_id="HEV0772545.1"
                     /translation="MSLLETAKRHQLNSEKYLSYLLECLPNEETLVNKEVLEAYLSWT
                     KVVQEKCK"
BASE COUNT          689 a          410 c          453 g          636 t
ORIGIN      
        1 ggaagactga tatgagacaa ggaatcgatt cactggctta tctggttaaa acccactttg
       61 aattggatcc tttctccggt caagtttttc tcttttgtgg tggacgtaaa gaccgcttta
      121 aagcccttta ctgggatggt caaggatttt ggctactata taaacgcttt gagaacggca
      181 gactgacttg gcccagtaca gaaaaggatg tcaaagctct cgcacctgaa caagtagatt
      241 ggctgatgaa aggcttttct atcactccaa aaatatagta gattgaaact agaatagtac
      301 acctctgctt ctaaaacatt gttagaaatc gattttactg tcctgatcga tttgtcctgt
      361 tcttatttca ttttactata aatccatcag aaagtcgtga tttctattga aatgaggact
      421 ttctttttag tataataaag ttagaaaaca gagagggaag ctcatggaag aagattgaaa
      481 atcattcaac aacagagtgc tacaattgat agtctcacca atgaacttgc ccttcttcgt
      541 gaacaagtgg cttatctgac tcaaaagctc tatggaaaat cctctgagaa aagtgtttgc
      601 ccctctggac aactcaacct ttttgaggaa gagtctccat ctgaggaaga tggagatgtt
      661 cccagttgaa acagaggaaa ttacctacaa acgtaagaaa tctaaaggga aacgccaagc
      721 tcttcttgcc caatttgatt cagaagaagt tcatcatcaa gtagaagaga ggatttgccc
      781 tgattgtcag ggagatctaa aagagattgg agggagtctt caaggacaag aattggtctt
      841 tattcctgcg caattaaaac gcatagatca tatccaacac gcttacaaat gccaagcatg
      901 cagtgataaa aatccgagtg ataaaatcgt gaaagctcct attcctaaag cccctttata
      961 acgagactat tgactcaagc ccttacttca tgcggatgaa acctcttatc gggttctaga
     1021 gagtgatagt cagttgactt actattggac ttttttgtct gggaaagctg agaatcaagc
     1081 aatcacgctg taccaccatg atcagcgtcg gagtggttta gtagtacaag aattcctagg
     1141 agattattct ggctatgttc attgtgacat gttgcggcag taacttagga ctttagtcct
     1201 ctagttctgc ctatgcgata gcagtccaaa gtttaggagt aaggcgacgc taagcttggt
     1261 aaactgcgaa cagctagaag cttatcgtca actggaagaa gctgcacttg ttggatgttg
     1321 ggcgcatgtg agaaggaagt tttttgaagt gccccccaag caagcagata aatcatcctt
     1381 aggagctaaa gatttagctt attgtgatca gttattttcc ttggaaagag actgggaggc
     1441 tttgccagct gatgaacgac tacagaaacg tcaagaacat ctccaacccc tactggaaga
     1501 cttctttgct tggtgccgtc gtcagtcagt tttatcgggt tcaaaactag gaagggcaat
     1561 tgaatacagc ctcaagtatg aagaaacctt taagaccatt ttaaaagacg gacatctggt
     1621 cctttccaat aatctagctg aacgcgccat taaatcattg gttatgggac ggagtaaaag
     1681 agtccagtgg actcttttag cctaagctca gtttaaaaaa gcgagggtgg ttgttttctc
     1741 aaagtttttg aaggagctaa agcaagagct attattatga gcttattgga aacagctaaa
     1801 cgtcatcaac taaatagtga gaaatatcta tcctatcttc tagaatgtct tccaaacgag
     1861 gaaactctcg taaacaaaga ggttttagag gcctatttat cgtggactaa agttgtacaa
     1921 gaaaagtgca aataagaaat ctccagatta ggaactatcc gtgagttctc tagtctggag
     1981 atttttcaat agacttcgtt attggacggt tacaatttat tatatgaaaa tcccatatca
     2041 ttctccaatt ctatatttta cctttctaaa tgtatagatt aaccacctaa ttatagcata
     2101 taacgcagat tcctttcaat cgtatgattt actgcattaa attaagtaaa aaaataaagg
     2161 cagtccgaag actgccgata tttatctc
//
LOCUS       DAVLHC010000116         2139 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.117, whole genome shotgun sequence.
ACCESSION   DAVLHC010000116 DAVLHC010000000
VERSION     DAVLHC010000116.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2139)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2139)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2139
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.117"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..649
                     /locus_tag="VXE25_002164"
     CDS             <1..649
                     /locus_tag="VXE25_002164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="DNA adenine methylase"
                     /protein_id="HEV0772546.1"
                     /translation="EKNGVPLSDVWNIPFLNPKAKERVGYPTQKPILLLEQIIKIATD
                     KNDIVLDPFCGSGTTLVASKILNRNYMGIDLSEEAINITQQRLENVIKTSSNLLNKGI
                     EAYRTKTEKEENILKLLQAKIVQRNKGIDGFLPKHFQKKPIPIKIQKNNECLNESISL
                     LQNAINSKKLDFGVVIKTHSDNLLFDFDTIPENIIVVDHFELTIEKWLSKSQQLL"
     gene            complement(1163..>2139)
                     /locus_tag="VXE25_002165"
     CDS             complement(1163..>2139)
                     /locus_tag="VXE25_002165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000122906.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEV0772547.1"
                     /translation="VKDYMKVDECKNNEKYSSAGHTFCWKKENSTYAEGLYWFYEGGS
                     FIIDIHDFYIREEVVQNSTYSMADYVSIYTSYIVSANGEKFSPYQTLTANSLCTFDFD
                     NIRDDFLFLLHENSYYLCVSIGFKRELLEKHLSSININPESFYGALLQTNQIILTKAL
                     ERVAMEILNCKMDAPAADFFFKAKANEWISIVIDTYLNRKKYKIEIDDDKALEDVARF
                     LDDHFATNVNQGTLEKISKMSGTKLKNLFKEKYCQSITEYTQRKRMNVAETLLLNTEL
                     SIKEIAESVGYSSASKFSIYYKRYKGKLPSEVRNLACKHHNFKCDYCD"
BASE COUNT          768 a          331 c          292 g          748 t
ORIGIN      
        1 agagaaaaat ggagttcccc tttcagatgt ttggaatata ccatttctta atccaaaagc
       61 taaagaaaga gtaggttatc ctacacaaaa acctattctg ttattagaac aaattataaa
      121 gattgctact gataaaaatg atatagtttt agacccgttc tgtggaagtg gaactacttt
      181 agtagcctcc aagattttga atagaaatta tatggggatt gatttatctg aggaagctat
      241 caatataact cagcaacgtc tggaaaatgt tataaaaaca agttcaaatt tattgaataa
      301 aggaatcgaa gcatatagaa ccaaaactga gaaagaggaa aacattctta aattattaca
      361 ggcaaaaatt gttcaaagaa ataaaggaat tgatggtttt ttacctaaac attttcaaaa
      421 aaaaccgata cctataaaaa ttcaaaaaaa taatgaatgt ctgaatgaga gtatctcttt
      481 attacagaat gctataaact ccaaaaaact tgattttgga gtagttataa aaactcattc
      541 agataattta ttatttgatt ttgatacgat ccctgaaaat ataatagtag ttgaccattt
      601 tgaacttaca atcgaaaaat ggttaagtaa aagtcaacag ttactatagt ttgcaaatta
      661 tttacagaaa gaacaaaaat gctctgaaac actgatttca aagcattttt tgttagttta
      721 aaattactcc cattcttctt ttccaaacgt acaatatatc caaaaccatt caaaatacta
      781 gattctattt tttataatat cactaaatcc acctaattat aggacgtttt cagattttta
      841 gtcccgtccc agtcccagta ccggagaaat attgttttaa tataatatct ctttttgtct
      901 tctaagctct taaaagcaaa agaacaagta aagagtcaag acaaggataa aaagtccata
      961 ttagggcaaa taaaaagctt taagacagat gacaaatcta agtcaaataa gaaagaccat
     1021 agtaaaggtg cagagagata aatattggcg gtcttcggac tgcctttatt tttttatcca
     1081 tttttcaaat caaatttatt cagactatat atgcacatat acacttaaat tcatataaaa
     1141 acatggcttg taaaaaatta ctttaatcac aataatcgca tttaaaattg tgatgtttgc
     1201 aagctaaatt acggacttca cttggaagtt ttcccttgta tcttttataa tagatagaaa
     1261 atttgctggc agatgaatat ccaacagatt ctgctatctc ttttatagat agttcagtgt
     1321 ttaaaagaag agtttcagct acattcattc tttttctttg agtgtactct gtaatgcttt
     1381 gacaatattt ttccttaaat aaatttttta atttagtacc actcatttta gatatttttt
     1441 caagcgtgcc ttgatttaca ttcgttgcaa aatgatcatc taagaatctt gctacatctt
     1501 caagtgcttt atcatcatca atttcaattt tatatttttt tctatttaag tatgtgtcaa
     1561 ttactatact tatccattca tttgcctttg ctttaaagaa aaaatcagcg gcaggagcgt
     1621 ccatcttaca atttaatatt tccattgcca ctctttctaa ggcctttgta agtataattt
     1681 gattagtttg aagtaaagcc ccataaaatg attctggatt aatgttaata gatgatagat
     1741 gtttttccaa aagttctctt ttaaatccaa tagaaacaca aagataatat gaattctcgt
     1801 gtaataaaaa taggaagtca tctcttatat tgtcaaagtc aaaagtacat aatgagtttg
     1861 cagtaagtgt ttgataagga ctaaactttt ctccatttgc gctgactatg tagcttgtgt
     1921 atattgaaac ataatctgcc atactatagg tactgttttg aactacttct tctctgatat
     1981 aaaaatcatg tatatcgata atgaagctgc ctccttcata aaaccaatat aggccttctg
     2041 cataagttga attctctttt ttccaacaaa atgtatgacc tgcacttgaa tacttctcat
     2101 tgtttttaca ttcatctact ttcatataat cttttacaa
//
LOCUS       DAVLHC010000117         2093 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.118, whole genome shotgun sequence.
ACCESSION   DAVLHC010000117 DAVLHC010000000
VERSION     DAVLHC010000117.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2093)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2093)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2093
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.118"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(<1..951)
                     /locus_tag="VXE25_002166"
     CDS             complement(<1..951)
                     /locus_tag="VXE25_002166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000571265.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772548.1"
                     /translation="MIELKIGKPSFGFLPYESHIEGILTGNNLNKIDYYLSMLDMEAI
                     CLQYGNKRIYDFFIGRNIQCNNIYREYSSRIDLSSEEALIPFLVDALAKGSFCYLSVD
                     TFCINKYISYKKEHIVHSPLVSGIDLDRNLIKISDFFDFTNYGIVWVPINEFIKGYFA
                     IQKVVEEGDIEETENWILKIEKINICKNKTEICDRMAINKVFKGYVLGSEEVKNSMDT
                     FSYINYRLANHKVFQKQSIVEQNLSVTGIKVYEYLKLYIEESIKEPQVLMRIKNLVLL
                     KKHFDVYKKIVQVLGINSEKVQACIEKAQLFLLIGMKINRS"
     gene            1181..1995
                     /locus_tag="VXE25_002167"
                     /pseudo
     CDS             1181..1995
                     /locus_tag="VXE25_002167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558050.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS5-like element IS1515 family transposase"
BASE COUNT          713 a          400 c          277 g          703 t
ORIGIN      
        1 agatctattt attttcatac caattagcaa aaacaactga gccttttcaa tacacgcttg
       61 caccttttca gagttaatac ctaacacttg aactattttt ttataaacat caaaatgttt
      121 ttttaataat acaagatttt taattctcat cagaacttga ggttctttaa tactttcttc
      181 aatataaagt ttcaaatatt catatacttt tattcctgtc acactaagat tttgctctac
      241 tatactctgt ttctgaaaaa ccttatgatt agctaaccta taatttatat aactaaatgt
      301 atccattgaa ttcttcactt cttctgaacc caaaacatag cctttaaaaa ctttatttat
      361 cgccattcta tcacaaattt ctgttttatt tttacatata tttatttttt ctattttcag
      421 tatccagttt tctgtttctt caatatcacc ttcttccacc accttttgaa ttgcaaaata
      481 tcctttaatg aactcattta taggaaccca aacaattcca taatttgtaa aatcaaaaaa
      541 gtcagatatt tttatcaggt ttctatctaa atcaattcct gaaaccaaag gtgaatgcac
      601 aatatgttcc tttttataac taatatactt attaatacag aatgtatcta ctgataaata
      661 acaaaaagaa cctttagcta acgcatcaac caaaaaaggg attaaagctt cctcactaga
      721 taaatctata cgtgacgaat actctctgta tatattatta cattgtatat ttcttccaat
      781 gaaaaaatca taaattctct tattaccata ttgaagacat atcgcttcca tatccagcat
      841 ggataaataa taatcaattt tatttaggtt atttcctgta agaattcctt caatatgtga
      901 ttcatagggc aaaaagccaa agcttggttt tccaatcttt aattcaatca tttttataaa
      961 tctcctaata taaatttact ttcatcgaac taaactcaaa ttgacataat ttctgtcatc
     1021 attcctgctt taattcacaa ctattcttat attatgcaaa aacttatacc tgattaacgc
     1081 aataatataa atttagagac taaccaagat gaattcgtcc tttttaacaa tttattcagt
     1141 agacttgttc ggtaactgta aaaagtgtta tactattttt atggaaacag tatacgacaa
     1201 agcacaaaaa cttaactcaa aaaacttcaa actattgatt ggtgtcaaaa aggaaacctt
     1261 tcaactcatg ctagaacacc tgaattcagc ctatcagatt cagcaccgaa aaggtggacg
     1321 tccacgtagt ctgcccatgg aagaccagct cattatgacc ctccgttact tgcgatatta
     1381 tcccactcag cgtctgctgg cctttgattt tggcgtcggt gtagctacgg taaatgccat
     1441 catcacttgg gtggaggata cacttcgtgc gtcaggtagc tttgatttgg accatttaga
     1501 agccccgagt gctgctgtgg ctattgacgt gaccgaaagt ccgattcagc gtccaaaaaa
     1561 aaccaaagca aaaattattc tggtaaaaag aaacgacaca ccttaaaaac tcaaattatg
     1621 ctggatttga cgacacataa agtctgtcaa atggcctttt ctgacggaca tacgcatgat
     1681 tttactctct tcaaagaaag tattggacaa agtttgcctg aaacgacgct tgcctttgtt
     1741 gacctaggtt atttaggcat cttgaaattt catgagaata ctttcattcc tgctaaaaat
     1801 tccaaaaatc gccgcctgag tgaggatgat aagcagttaa ataaagagat gtcagcgata
     1861 cgaattgaaa ttgaacattt taacgctaaa ttcaagacct tccaaatcat gtcagtccct
     1921 tatcgtaacc gcagaaaacg tttcgagtta cgggcggaat taatttgtgc catcatcaat
     1981 tatgaagtga actagattct gaacaagtct agtataattt taccacaaag taacatgatt
     2041 tgcaagcgat ttcaataata aagatatatg attatcctca ggaataaata aat
//
LOCUS       DAVLHC010000118         1993 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.119, whole genome shotgun sequence.
ACCESSION   DAVLHC010000118 DAVLHC010000000
VERSION     DAVLHC010000118.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1993)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1993)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1993
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.119"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            5..1030
                     /locus_tag="VXE25_002168"
     CDS             5..1030
                     /locus_tag="VXE25_002168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000573792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HEV0772549.1"
                     /translation="MIEVSIIIPIYNAEKTIKNCVDSALKQNLESLEVILVNDGSNDS
                     TAEILNQYDRNSRVKIFHQLNKGVSTARNKGLSHASGEYVFFLDSDDILDDGMLSKMY
                     QFVKNNKVDLLSCWHKEPATTQYGGNENKSTSFIARTREEIGAHFVDIFPRSACAKLF
                     FRKIIEENNITFSTEMSLGEDMSFVYQYLMVSKSIGVIDGVYYNIQNVNPQSLSKRYV
                     QNIENSLIIQNQLWNQLLEVYPKIEENYYKQHMDFRFYLANLYVNNLFKFDSPYSSKE
                     KLDQIAQQLKKYRLFLDEKVSKEKMPKNINEMIVFYLLKLKIPVLIYSFYSFKEWWKR
                     RKIKNEG"
     gene            1038..>1993
                     /locus_tag="VXE25_002169"
     CDS             1038..>1993
                     /locus_tag="VXE25_002169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000389753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HEV0772550.1"
                     /translation="MEDLISIVVPVYNVEKYLKKSIESILNQTYQNIEILLVDDGSTD
                     SSGKICESFSKVDPRIRVFHKENGGLSDARNFGIEQMKGQYVAFIDSDDYISKDYVWK
                     LYSSIKNNDSEVSICSFLLVDEKGEKIKDELLDSGKICLTGQQILEKVLTADGYRYVV
                     AWNKLYRSTLFEKLKFKKGMLYEDEFLNYPLFWDCKRVSIVEEPLYLYVQRKGSIVQS
                     NMTLEKIKMKDEMHTSRIEFYSEKGHSFLHEKACQQYCNWIVTATTNHSKILNPNFSK
                     YLQRQFRKFAKYTRNNDIRLIVQNILGFIDIRLAAYVKSKVM"
BASE COUNT          729 a          229 c          376 g          659 t
ORIGIN      
        1 ttggatgata gaagtatcaa tcataattcc aatatacaat gctgaaaaaa ctattaaaaa
       61 ttgtgttgat agtgccttaa agcaaaattt agaatctctt gaagtgattt tggtgaatga
      121 tgggtctaac gattctacag cagaaatttt gaaccagtac gacaggaatt caagggttaa
      181 gatttttcat cagcttaata aaggggtgtc tactgctaga aataaggggt tatctcatgc
      241 tagtggagag tatgtatttt ttctagattc agatgatatt ttagatgatg gtatgctttc
      301 taaaatgtac caatttgtaa aaaataataa agttgatctc ttatcttgtt ggcataaaga
      361 acctgctaca actcaatacg gtggaaatga gaataagtca acttcattta ttgcacgtac
      421 aagagaagaa ataggtgctc attttgttga tatctttccg agaagtgctt gtgccaaatt
      481 gttttttcgc aaaataattg aagaaaataa tattactttt tcgactgaga tgtcactagg
      541 tgaagatatg tcatttgtgt atcaatactt aatggtttct aaaagtattg gagttattga
      601 cggggtgtat tataatattc aaaatgtaaa tccacagtcg ttatctaagc gctatgtgca
      661 gaatattgaa aattccctaa taattcagaa ccagttatgg aatcaactgt tggaagttta
      721 tcctaaaatt gaggagaact actataagca acatatggat tttagatttt accttgctaa
      781 cttgtatgta aataatttat ttaaatttga ttctccgtat tcatcaaaag aaaaactaga
      841 ccaaattgct caacaattaa aaaagtatag attattttta gatgaaaaag tcagcaaaga
      901 aaagatgcct aaaaatataa atgagatgat tgttttttat ttactaaaat tgaaaattcc
      961 agtgttgatt tattcttttt attcgtttaa agagtggtgg aagagaagaa aaattaaaaa
     1021 tgaaggataa ataagttatg gaagatttga taagcattgt tgttccagtc tataacgtgg
     1081 aaaaatattt aaaaaaatca atagaaagta ttttgaatca gacttatcaa aatatcgaga
     1141 ttttattggt tgatgacgga agcacagata gtagtgggaa aatttgtgaa tcatttagta
     1201 aagttgatcc taggataaga gtatttcata aagaaaatgg tggtttatca gatgctcgga
     1261 attttggaat tgagcaaatg aaaggtcaat atgtagcgtt tattgatagc gatgactaca
     1321 tatctaagga ttatgtctgg aagttgtatt cttctataaa aaataatgat tccgaggtgt
     1381 cgatttgttc ttttttatta gtcgatgaaa aaggggaaaa aataaaagat gagctattag
     1441 attcgggaaa aatatgcttg actggtcaac aaatattaga aaaagtatta acagccgacg
     1501 gctatcgcta tgttgttgct tggaataagc tttatcggtc aactttattt gaaaaattaa
     1561 aatttaaaaa aggaatgttg tatgaggatg aatttcttaa ctatcctcta ttttgggact
     1621 gtaaaagggt atcaattgta gaggagccgt tatatttata cgttcaacga aaaggaagca
     1681 ttgtacaaag taatatgact ttagaaaaaa taaagatgaa ggatgagatg catacttcac
     1741 gcattgagtt ttattcagaa aaggggcatt cttttttgca cgaaaaagcg tgtcaacagt
     1801 actgcaattg gattgttaca gcgactacca atcatagtaa gattttaaat cctaattttt
     1861 caaagtattt acaacgacag tttagaaagt tcgctaaata tacacgaaac aatgatatta
     1921 gactaattgt gcagaacatt ctaggattta tagatattcg tttagcagct tatgtaaaat
     1981 caaaagtaat gta
//
LOCUS       DAVLHC010000119         1943 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.120, whole genome shotgun sequence.
ACCESSION   DAVLHC010000119 DAVLHC010000000
VERSION     DAVLHC010000119.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1943)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1943)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1943
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.120"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..1314
                     /locus_tag="VXE25_002170"
     CDS             <1..1314
                     /locus_tag="VXE25_002170"
                     /EC_number="6.1.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000021542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine--tRNA ligase"
                     /protein_id="HEV0772551.1"
                     /translation="LYEKKFLYTKKIKQLYCTFDNQFLPDRFVEGKCPNCGTHSRGDQ
                     CDNCSAILDPIDLVDKRCSICSNEPEVRETEHFYYVFSEFQNLLETYLNDAEETVRWR
                     KNAINLTKRYLREGLPDRAVTRDLPNGIPVPIDGFRDKKIYVWFEAVAGYYTASVDWA
                     QKLQNNITDFWNNRTKSYYVHGKDNIPFHTIIWPAILSGLEIEPLPEYIISSEYLTLE
                     NKKISTSNNWAIWLNDIIKKYDADSIRYFLTINAPEMKDANFSWREFIYSHNSELLGS
                     YGNFINRTLKFIEKYFESEIPTKYLEGEILYNLKELYTTVGNLVESGHMKQALEEIFE
                     YIRSANKFYDDMKPWALRESDIEKCKEVLATCVIIILNLGQMLNPFIPFSGKKIEDMF
                     KTKLNTWNYISNLPNKLSDVSMLFDRIDLKKIDEEVLELQQTSSR"
     gene            1415..>1943
                     /locus_tag="VXE25_002171"
     CDS             1415..>1943
                     /locus_tag="VXE25_002171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001061789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein phosphatase"
                     /protein_id="HEV0772552.1"
                     /translation="MNNLTLLKEYNFRDLGNHLTQTGQKIKPKTLFRSSKLFGISKID
                     VDLLQSYGITKVIDFRSANEIKKAPDPDIKNIKNIVIPIFYNDDSELTEFPIEFFNKS
                     DAGFQHMIKTYDQMINQKQSKLGYKKFFKLLLSHPKDESLLFHCSMGKDRTGIASLFL
                     LYILGVDMNDIFHDYL"
BASE COUNT          739 a          258 c          326 g          620 t
ORIGIN      
        1 ttatacgaga agaaattttt gtatacaaaa aaaattaaac aactctattg tacatttgat
       61 aatcaattct tacctgatag gttcgttgaa ggaaaatgcc cgaattgtgg aacccattca
      121 agaggagatc aatgtgataa ttgctcagca attttagatc ctatagattt agttgataaa
      181 agatgttcta tttgttccaa tgaaccagaa gttcgtgaga cagaacactt ttattatgtt
      241 tttagtgagt ttcaaaattt gttagagact tacttaaatg atgctgaaga aacagtgaga
      301 tggcgaaaaa atgcaataaa tctaactaaa aggtatttac gggaaggttt acctgatcga
      361 gctgttactc gtgatctacc aaatgggatt ccagttccca ttgatggttt tagagataaa
      421 aaaatatatg tctggtttga agcggtagca ggttactaca cagcaagtgt tgattgggcg
      481 caaaaacttc aaaataatat tactgatttt tggaacaatc ggacaaagtc atattatgtt
      541 catggaaaag ataacatccc atttcatact attatttggc cggcaatact ctcaggttta
      601 gaaatagagc ctcttccaga gtatattatt tctagtgaat atttaacgtt agaaaacaaa
      661 aaaatatcaa caagtaataa ttgggctata tggcttaacg atatcataaa aaaatatgat
      721 gctgattcaa tccgatactt cctaacaata aatgctcctg agatgaaaga tgcaaatttt
      781 tcttggagag aatttattta tagtcataac tcagaattat taggatcgta cggtaatttt
      841 atcaatagga ctctaaagtt tattgaaaag tattttgaat ctgaaatacc cactaaatat
      901 ctcgaaggag aaattttata taatttgaaa gaattatata caacagtagg taatttagtt
      961 gagagcgggc atatgaaaca ggcattagaa gaaatttttg aatatattag atcggctaat
     1021 aaattctatg atgatatgaa accgtgggca ttgcgagagt ccgatattga aaaatgtaaa
     1081 gaagtcttag ctacttgtgt aatcattata cttaatttag gacaaatgtt aaatccattc
     1141 attccttttt ctggtaaaaa gattgaggat atgtttaaaa caaagctaaa tacttggaat
     1201 tatatttcaa accttcctaa caagctatca gatgtatcaa tgttgtttga taggattgat
     1261 ttgaaaaaaa ttgacgagga agttttagaa ttgcaacaaa catccagtag ataattcaaa
     1321 aatactcgaa agtagccttt tttaatttaa attaacaacc ggagatgttg aataaaataa
     1381 agatggtttt ttgagcatat tatggagaaa agcattgaat aatctaactt tactaaaaga
     1441 atataatttt agagatcttg gaaaccacct cactcaaaca ggacaaaaaa taaaacctaa
     1501 aacattattc cgttcaagta aactatttgg aatctctaaa attgatgtcg atttgttaca
     1561 gagctatgga ataacaaaag tcattgactt tcgatcagcg aatgaaataa aaaaagctcc
     1621 agatccagat ataaaaaata taaaaaatat agtaattcca atattctata atgatgattc
     1681 agagttgaca gaattcccaa tagaattttt taacaaatca gatgcaggtt ttcaacatat
     1741 gataaaaact tatgatcaaa tgatcaatca aaaacagagt aaacttggtt acaagaaatt
     1801 ctttaaatta ttactaagtc atccaaaaga tgaatctctt ttgtttcatt gttcaatggg
     1861 gaaggatcga acaggaatag ctagcttgtt cttgctttat atattgggag tagatatgaa
     1921 cgatattttt catgattact tac
//
LOCUS       DAVLHC010000120         1861 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.121, whole genome shotgun sequence.
ACCESSION   DAVLHC010000120 DAVLHC010000000
VERSION     DAVLHC010000120.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1861)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1861)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1861
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.121"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            302..1648
                     /gene="gdhA"
                     /locus_tag="VXE25_002172"
     CDS             302..1648
                     /gene="gdhA"
                     /locus_tag="VXE25_002172"
                     /EC_number="1.4.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001858584.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-specific glutamate dehydrogenase"
                     /protein_id="HEV0772553.1"
                     /translation="MTSAKEYIQSVFETVKARNGHEAEFLQAVEEFFNTLEPVFEKHP
                     EYIEENILARITEPERVVSFRVPWVDRDGKIQVNRGYRVQFNSAVGPYKGGLRFHPTV
                     NQGILKFLGFEQIFKNVLTGLPIGGGKGGSDFDPKGKTDAEVMRFCQSFMTELQKHIG
                     PSLDVPAGDIGVGGREIGYLYGQYKRLNQFDAGVLTGKPLGFGGSLIRPEATGYGLVY
                     YTEEMLKANGNSFAGKKVVISGSGNVAQYALQKATELGATVISVSDSNGYVIDENGID
                     FDLLVDVKEKRRARLTEYAAEKATATYHEGTVWTYAGNYDIALPCATQNEINGEAAKR
                     LVAQGVICVSEGANMPSDLDAIKVYKENGIFYGPAKAANAGGVAVSALEMSQNSLRLS
                     WTREEVDGRLKDIMTNIFNTAKTTSETYGLDKDYLAGANIAAFENVANAMIAQGIV"
BASE COUNT          587 a          343 c          358 g          573 t
ORIGIN      
        1 gtataaatat tgctttcctc caaaatggtc atagttttac tggcaaatct aacatatcac
       61 ggataaatta acaagtgatt tctgaattgc taaacatttt cttttcttat agcatacttt
      121 aagattttgt ctttgagaaa gatatttcca agaaaaacgt tcgttttttt atctattttc
      181 aaaaaaacca aaaaactgaa ttgaaagaat ttttagaaaa tttctgtttt ttctttacag
      241 tgaaaaaaaa ttctgctata atgtcttatg taataaaata tgacaataaa aggagaacga
      301 tatgacatct gctaaagaat atatccaaag cgtgtttgaa actgtgaaag ctcgtaacgg
      361 gcacgaggct gaattcctcc aagctgttga agaatttttc aacactttag aacctgtatt
      421 tgaaaaacac cctgagtata tcgaagaaaa tatcttggca cgtattactg agcctgagcg
      481 cgtggtttct ttccgtgttc cttgggttga ccgtgatgga aaaattcaag taaaccgtgg
      541 ttaccgtgtt caattcaact cagctgttgg accatacaaa ggtggacttc gtttccaccc
      601 aactgtaaac caagggatct tgaaattcct cggatttgaa caaatcttta aaaatgtctt
      661 gactggactt cctatcggtg gaggtaaagg tggatcagac ttcgatccta aaggtaaaac
      721 agatgctgaa gtgatgcgct tctgccaaag cttcatgact gaattgcaaa aacacatcgg
      781 accatcactt gacgtacctg ctggtgatat cggtgttggt ggacgtgaaa ttggttacct
      841 ttacggtcaa tacaaacgtc ttaaccaatt tgatgctggt gtcttgactg gtaaacctct
      901 tggatttggt ggtagcttga ttcgtccaga agcaactggt tacggtttgg tttactatac
      961 tgaagaaatg ctcaaagcta acggtaacag ctttgctggt aagaaagtcg ttatttcagg
     1021 ttctggtaac gttgctcaat atgctcttca aaaagcaact gaactcggtg caactgttat
     1081 ttctgtttct gactcaaatg gttatgtcat cgatgaaaat ggtatcgact tcgatctttt
     1141 ggttgatgtt aaagaaaaac gtcgtgctcg tttgactgag tatgcagctg aaaaagcaac
     1201 tgcaacctac cacgaaggta ctgtatggac ttacgctgga aactatgaca ttgctcttcc
     1261 atgtgccact caaaacgaaa tcaacggtga agcagctaaa cgtttggttg ctcaaggcgt
     1321 tatctgtgta tctgaaggtg ccaacatgcc gagcgacctt gatgccatca aagtttacaa
     1381 agaaaatggt atcttctacg gacctgcaaa agctgccaac gctggtggtg tagccgtttc
     1441 agctcttgaa atgagccaaa acagtcttcg cctctcatgg actcgtgaag aagttgatgg
     1501 ccgtctcaaa gacatcatga caaacatctt caacacagct aaaacgactt cagaaacata
     1561 cggtcttgat aaagactacc ttgcaggagc taacattgct gcctttgaaa atgtagcaaa
     1621 tgccatgatt gcacaaggta ttgtttaaga tttatttact caatcctcaa tcactacgat
     1681 tggggatttt tagcttgaat taaaaaattg gaaaatctaa ttaaataaaa tgaaatgaaa
     1741 taaaaactga acaaattgat tgcggaattc aaaccaattt ctaacatatt tctagaaatt
     1801 aatttgactt ttctaatcga tttgttcata tcttatttca atttactata cttacttgac
     1861 c
//
LOCUS       DAVLHC010000121         1794 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.122, whole genome shotgun sequence.
ACCESSION   DAVLHC010000121 DAVLHC010000000
VERSION     DAVLHC010000121.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1794)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1794)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1794
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.122"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            3..1004
                     /locus_tag="VXE25_002173"
     CDS             3..1004
                     /locus_tag="VXE25_002173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000789954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEV0772554.1"
                     /translation="MKNINGKKVTIYDIARLSGFSPKTVSRVINGGVNVKEETYQAIQ
                     KVIEELSYIPNAYAKNLTKKEAINILISVKKIDSFPLIWFHTLLDKVLRTCKEFGVNA
                     IVEYFGEEDTISNSIISSTGSLVDGVIVFYESVDDIRIQYLKKNHMPFLVFGESQTSG
                     VVYVSNNNFQATYDMMKAVTEEKFKNMWLLMGGESHVNKDRERGVRSFLNDKNYFMDL
                     KVIYGLSTIDSVYSYAMQHLTTQNYPDIIFVSGDEKVQGLIRACYEKGILIPDDISII
                     GFDNIPISQYYTPALSTIAPNYVKLAKEMIEGVLAIIKGESVTSVEVSPKFVRRQSF"
     misc_binding    1216..1445
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            1612..1689
                     /locus_tag="VXE25_002174"
                     /pseudo
     CDS             1612..1689
                     /locus_tag="VXE25_002174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002674100.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
BASE COUNT          598 a          241 c          368 g          587 t
ORIGIN      
        1 aaatgaaaaa tataaatggg aaaaaggtaa ctatttatga tattgcacgt ttatcaggtt
       61 tttctccaaa aacagtttca cgagttatta atggtggagt aaatgttaaa gaagaaactt
      121 atcaagcgat tcaaaaagtt atagaggaat tgtcgtatat tccaaatgcg tatgcaaaaa
      181 atttaactaa aaaagaagct ataaatatat tgatttctgt aaaaaaaatc gactcttttc
      241 ctttaatttg gtttcatacg ctgttagata aagtgttacg gacgtgtaaa gaatttggtg
      301 ttaatgctat agttgagtac tttggagagg aggatacaat tagtaattcg attatatcaa
      361 gcacaggtag cctagtagat ggtgttattg ttttttatga aagtgtagat gatatcagaa
      421 ttcagtattt aaagaagaac catatgcctt ttcttgtttt cggtgaatct caaacgtctg
      481 gagtagtcta tgtatctaat aataattttc aagctactta tgatatgatg aaagctgtaa
      541 ctgaagaaaa atttaaaaat atgtggttgc ttatgggagg agaatctcat gttaataagg
      601 atcgtgaaag aggtgtgcgt tcttttctga atgataaaaa ttactttatg gatttaaaag
      661 tcatttatgg attatctaca attgattcag tttattctta tgcaatgcag cacttgacta
      721 cccaaaatta tccggacatt atttttgttt caggagatga aaaggttcag ggcttgattc
      781 gtgcgtgcta tgagaaagga attcttattc cagatgatat ttctattatt ggatttgata
      841 atattcctat ttctcagtat tatactccag ctttgtctac aattgctccc aattatgtta
      901 aattggctaa agaaatgata gaaggtgttt tagcaattat taaaggggaa agtgtcacat
      961 ctgttgaagt ttctcctaaa tttgttagga gacagagttt ctagtattgt ttaattcttg
     1021 aaaatcctag tggaaaagat ggagtgttct aaaataagtt ctgtttagcc tccattcagt
     1081 ttctattgag ttggatccaa tttctaacaa gtgggacatg ttcatgttcg atctaaggaa
     1141 gacatggtca cattcgaatg atattttcaa aaaaatcgta aaaaagtctt gacaaagaaa
     1201 aaacaaagta ttaaaataag ttcaacaaat cagaaaagta actatttttg atcttcaggg
     1261 agcctgtggt ggttgtgaat aggtggttgg aagtagtgaa agtgggctga ttttgaaaat
     1321 gaatttgaaa taatgaaaat tcggtgcgca caccttacag tgcagcttgt tgttaaacaa
     1381 ggcagagatg taaagggata gtccctttat aattgaggtg gcaccgcgtt accaacgccc
     1441 tcacacggaa gtatattctg tgtgtgggct tttttctatc cgtcgtttgg tttatctttt
     1501 attagggcct taagtcgctt tgatgaactt gagttctatc tacagctcct tgcctactac
     1561 taaaagcaaa caaaaaggct ggactaatac gaaaaaagct agtaatactc aatgaaaatc
     1621 aaagagcaaa ctaggaaact agccgcaggc tgctcaaaac actgttttga ggttgtggat
     1681 agaactgacg aagtcagctc aaaatactgt tttgaggttg tggatagaac tgacgaagtc
     1741 agctcaaaat actgttttga ggttgtggat agaactgacg aagtcagctc aaaa
//
LOCUS       DAVLHC010000122         1777 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.123, whole genome shotgun sequence.
ACCESSION   DAVLHC010000122 DAVLHC010000000
VERSION     DAVLHC010000122.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1777)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1777)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1777
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.123"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..>1777
                     /locus_tag="VXE25_002175"
     CDS             <1..>1777
                     /locus_tag="VXE25_002175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000417187.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase M26"
                     /protein_id="HEV0772555.1"
                     /translation="KQVAPLPEYTGPQASAIVEPEQVAPLPEYTGVQAGSIVEPEKVE
                     APKEYTGKIEQPSAEDTKPENEASSTNGESERPKDKIKEEKQVDKKLELRNVSNVELY
                     TVENNKYRHITAVDGALDSSLKYFMKVKSENFKDIMLPVTKIESTTKNNKEVYKIVAH
                     AENLIQHENNVISNDYTYYLPKTQQSETGVYTSFKNLVDAMNSDPNGTFHLGATMDAR
                     EVELPDDQESYVKNEFYGKLIGENNGKYYAIYNLKKPLFKTLNTATIQNLSIKEANVS
                     SKEDAATISKEAKYNTLIDNVHSDGIIAGERGIGGLVSKVDNSRISNSSFTGRITNTY
                     DTTVGYEIGGLVGKLSGSLASIEKSIASIDIASNAKSGDQIVGGIAGVVEKSATIKYS
                     YVEGNVNNVRHFGKVGGVAGNLWDRDSQDVSKSGKLSYVLSDVNVTNGNAISGDNFDN
                     MKEDHAYSSKGNKVVNVVQVDDELVTKDSDVQRGTVLDADKVKEKKAELVSKHSTKVE
                     DFDFTSRYTTIYNEVTGYQKSREQVYKNIEKLLPFYNRETIVKYGNLVDESSELFTKE
                     LLSVVPMKNNEVITDINKNKQEINKL"
BASE COUNT          708 a          234 c          347 g          488 t
ORIGIN      
        1 aaacaggtag caccgcttcc agaatataca ggaccacaag ccagcgctat tgttgaacca
       61 gagcaagtag caccactacc agaatacaca ggggtacaag ccggatcgat agtcgagcca
      121 gagaaagtag aagcaccgaa agaatatact ggtaaaatcg aacaacctag tgcagaagat
      181 actaaacctg aaaatgaggc aagctctaca aatggggaat cggaacgtcc taaagataaa
      241 attaaagaag aaaaacaagt cgacaagaaa ctagaactta gaaatgtttc aaacgtggaa
      301 ttatatacgg tagaaaataa taaatatcga catattacgg ctgtagatgg tgctttagat
      361 agttcattga agtatttcat gaaggtaaaa tcagaaaatt ttaaagatat aatgttgcct
      421 gttactaaaa ttgaaagtac aacaaaaaac aataaagaag tatacaaaat tgtggctcat
      481 gcagaaaatc taattcaaca cgaaaacaat gttatttcga atgactatac atattattta
      541 ccaaaaactc agcaaagtga aactggcgtc tatacatcat ttaaaaattt agttgatgca
      601 atgaatagtg accctaatgg aacattccat ttaggtgcaa ctatggatgc tcgtgaagtt
      661 gaacttccgg atgatcaaga aagttatgta aaaaatgaat tttacggaaa attaataggt
      721 gaaaataatg gtaagtatta tgctatttat aacttgaaaa aacctttatt taaaactcta
      781 aacaccgcta ctattcagaa tctttcaata aaagaagcga atgtttcttc taaagaagat
      841 gctgctacaa tatcgaaaga agcaaaatac aatactctta tagataatgt tcattctgat
      901 ggtattatag ctggtgaacg tggaattggt ggattggttt caaaagtaga taactcgaga
      961 atttctaata gtagttttac aggcagaata actaacacat atgatacaac tgtagggtat
     1021 gaaattggtg gtttagtagg taaactttct ggttcgcttg cttctataga gaaatcaata
     1081 gcatcgattg acatagcctc taatgcaaaa tcaggagatc aaattgttgg tggtatagcc
     1141 ggagttgttg agaaaagtgc gacaattaag tatagctatg ttgaaggaaa tgttaacaat
     1201 gtgcgacact ttggtaaagt tgggggagtt gcaggtaatc tttgggatag agattcacaa
     1261 gatgtaagta aatcaggtaa actatcatat gttttaagtg atgttaatgt aacaaatggt
     1321 aatgctatat cgggtgataa ttttgataat atgaaagaag atcatgctta tagtagtaaa
     1381 ggcaataaag tagtaaatgt agtccaagta gatgatgaac ttgtgactaa agattcagat
     1441 gtacaaagag gtacggtatt agatgctgat aaagtaaaag agaaaaaggc agaattggtt
     1501 tccaaacaca gcactaaagt agaagatttt gattttactt caagatacac tactatttac
     1561 aatgaagtaa caggttatca aaagtcgaga gaacaagtat ataaaaatat tgaaaaacta
     1621 ttaccgttct ataatcgaga gacaattgtt aaatatggta atttagtaga tgaaagcagc
     1681 gagctattta ctaaagaact tctatcagtt gttcctatga agaataatga agtaataact
     1741 gatattaata aaaataaaca agaaataaac aaattgt
//
LOCUS       DAVLHC010000123         1719 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.124, whole genome shotgun sequence.
ACCESSION   DAVLHC010000123 DAVLHC010000000
VERSION     DAVLHC010000123.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1719)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1719)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1719
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.124"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..697
                     /locus_tag="VXE25_002176"
     CDS             <1..697
                     /locus_tag="VXE25_002176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="HEV0772556.1"
                     /translation="KLRLVQVVGAFCPPNYITDFHKNWPKIDLFNGYGLTEASPRVAV
                     LGGEELYANPRCVGYPISGVGVHIDTSSNNTQEGEICVTGPNIMVEYYLNEELTSKIK
                     IGGMLRTGDIGYFDDKNRLYILGRKDNRYIKSGKNIFPEEIESVVRKLPFISEVIVYP
                     KIESGRLISILEYTICNDEEKDLNQEASEIIKLCKDNLEDYKIPDQYRKVKNIPHTST
                     GKVKRDRNNYYNE"
     gene            690..>1719
                     /locus_tag="VXE25_002177"
     CDS             690..>1719
                     /locus_tag="VXE25_002177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001003686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase"
                     /protein_id="HEV0772557.1"
                     /translation="MNELCKKYVYQLQNELNQYCDNLEGIHVIAYGSNGSNDLSISSD
                     FDVCLIVNDDSFVAMNQRLICDFTKLFHFQENLPIDKDIPLSNKLIYLSSEVELFLDN
                     PPFISDSKKVKIEDIKKTKNFLTSRTMKQRLLLNILTTDSTVLFGDEDYVNNLKYRAW
                     EDIEKIIERAYNIKLTTKNENEFLNLLYQNPVSKASGEYYLGYKKEKRNVVKHLERNV
                     HRLAILNEKKVEDIIDLSENVNRLLLKDYSFLFPSETIKKMISTYPEKKSCSIKEVLS
                     SKLTIASNNFLITNGSLEGMNIIIANLVQNNIGYLTPTFWGYGDSAKRYNKSVISAPL
                     SDIYNYNVT"
BASE COUNT          657 a          198 c          307 g          557 t
ORIGIN      
        1 gaaattaaga ttagtacagg ttgtaggtgc attttgtcct ccaaattata taacagattt
       61 tcataaaaac tggccaaaaa ttgatttatt taatggttat ggtttaacag aggcctctcc
      121 tagagttgct gtattaggag gagaagaatt atatgcaaat cctaggtgtg taggttatcc
      181 aatttcagga gttggtgtgc atattgatac aagtagcaac aacacccaag agggagaaat
      241 ttgtgttact ggtcctaata ttatggttga atattacttg aacgaagagc ttacttctaa
      301 aataaaaatt ggaggtatgt taaggactgg agacattggt tactttgatg ataaaaacag
      361 gttatatatt ttaggcagaa aagacaatag gtatataaaa tcaggaaaaa atatatttcc
      421 ggaagaaata gaatctgtag taagaaaatt accttttata tccgaagtaa tagtttatcc
      481 taaaatagaa tctgggagat taatatctat tcttgaatat actatttgca atgatgaaga
      541 gaaagatttg aatcaagaag caagtgaaat aataaaatta tgcaaagata atctagaaga
      601 ttataaaatc cctgatcaat ataggaaggt taaaaatatc ccgcacactt ctacagggaa
      661 agtaaaacgt gataggaata attattataa tgaatgagct atgtaaaaaa tatgtttatc
      721 aattacaaaa cgaactaaat cagtattgtg ataatctgga gggaatccat gttattgctt
      781 acggttcaaa tggtagtaat gatttgtcta tttcatctga ttttgatgtt tgtcttattg
      841 ttaacgatga ttcatttgtt gctatgaatc agcggttgat atgtgacttt acaaagttat
      901 ttcattttca agaaaattta ccgatagata aggatattcc tttgagcaac aaacttattt
      961 atctaagcag tgaggttgaa ttatttttgg ataatccgcc gttcatatca gattctaaga
     1021 aagttaagat tgaagatatt aaaaaaacga agaacttttt aacttcaaga actatgaaac
     1081 aacgtctctt actaaatatt ttgactacag attctacagt tttatttggt gatgaagatt
     1141 atgttaataa tctgaaatat agggcatggg aggacattga aaaaataatt gaaagagcgt
     1201 ataatattaa attaacgacc aaaaatgaaa atgaattctt aaatttacta tatcaaaacc
     1261 cagtatcgaa agcaagtgga gagtattatt taggatataa aaaagaaaaa aggaatgttg
     1321 ttaaacattt agaaaggaat gttcaccgat tagcaatttt gaacgagaaa aaggtggaag
     1381 atataattga tttatctgaa aacgtcaata ggttactctt gaaagattac tcatttttat
     1441 ttccttctga aactataaaa aaaatgataa gcacatatcc agaaaaaaaa tcatgcagta
     1501 ttaaagaagt tttgtcttct aaattaacaa tagccagtaa caatttcttg attacaaacg
     1561 gttctttaga gggtatgaat attataattg cgaacttggt tcaaaataat ataggatatt
     1621 taacccctac tttttgggga tatggggatt ctgcaaaaag gtataataaa tcagtgattt
     1681 cggcaccttt gtcagatatt tataattata atgttacag
//
LOCUS       DAVLHC010000124         1636 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.125, whole genome shotgun sequence.
ACCESSION   DAVLHC010000124 DAVLHC010000000
VERSION     DAVLHC010000124.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1636)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1636)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1636
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.125"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(<1..743)
                     /locus_tag="VXE25_002178"
     CDS             complement(<1..743)
                     /locus_tag="VXE25_002178"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase family
                     protein"
                     /protein_id="HEV0772558.1"
                     /translation="MDIDTSRLRTGLPQVGVQPYRQVHAHSTGNRNSTAQNEADYHWR
                     KDPELGFFSHVVGNGRIMQVGPVNNGSWDVGGGWNAESYAAVELIESHSTKEEFMADY
                     RLYIELLRNLADEAGLPKTLDTDDLAGIKTHEYCTNNQPNNHSDHVDPYPYLASWGIS
                     REQFKQDIENGLSAATGWQKNGTGYWYVHSDGFYPKDKFEKINGTWYYFDGSGYMLSD
                     RWKKHTDGNWYWFDNSGEMATGWKKIAEK"
     gene            complement(743..1078)
                     /locus_tag="VXE25_002179"
     CDS             complement(743..1078)
                     /locus_tag="VXE25_002179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001186237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage holin"
                     /protein_id="HEV0772559.1"
                     /translation="MQQITEIITNGAISILVVLAGVVVRAVKDYLVQKGGEKTIKIVE
                     ILAKNAVNAVEQVAAETGYKGDEKLAQARAKIRAELTKYNISMTDKDLDTFVESAVKQ
                     MNDAWKGQE"
     gene            complement(1082..1381)
                     /locus_tag="VXE25_002180"
     CDS             complement(1082..1381)
                     /locus_tag="VXE25_002180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004246694.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772560.1"
                     /translation="MPIEEAEKIAQSQVAWAILFILLFFIIIRYLIKTSDKREKKIMD
                     LHEQSKADSNRREERLMTHLEKTTTELTTITHAVGDIQKEMVRMNDRMEEIEKGE"
     gene            complement(1391..1600)
                     /locus_tag="VXE25_002181"
     CDS             complement(1391..1600)
                     /locus_tag="VXE25_002181"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001839378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772561.1"
                     /translation="MYRDVQKRPVIVNGRRQLKDVETVWAFNQWGGTIATINVAVLLN
                     HEFYIMKFDAEGNPDWTDPTVKPKE"
BASE COUNT          377 a          406 c          325 g          528 t
ORIGIN      
        1 cacttctcag cgattttctt ccagcctgta gccatttcgc ctgagttgtc gaaccagtac
       61 caattaccgt ctgtgtgctt cttccagcgg tctgaaagca tatagcctga gccatcgaaa
      121 taataccagg taccgttgat tttctcaaac ttatcttttg gataaaagcc gtctgagtgt
      181 acgtaccagt agccagtgcc atttttctgc cagcctgttg cagcgctcaa gccgttttcg
      241 atgtcttgct taaactgttc acggctaatg ccccaacttg caagatatgg atatggatcc
      301 acatggtctg agtggttgtt tggttggtta ttggtacagt attcatgcgt cttgatacct
      361 gccaagtcgt ctgtatcaag agtcttcggc aagcctgctt cgtccgctag attgcgtagc
      421 aattcgatat agaggcgata gtcagccata aactcttcct tagttgaatg gctttcaatc
      481 agttcaaccg ctgcataact ctcagcattc caaccgcccc caacatccca acttccgttg
      541 ttcacaggtc ctacctgcat gatgcgaccg ttcccaacaa cgtgcgagaa aaaacctaat
      601 tctgggtctt tccgccagtg ataatccgct tcattttgag cggttgagtt acggttgcct
      661 gttgagtggg catgtacttg tcgataaggc tgcaccccaa cctggggcaa gcctgttcgt
      721 agtctgcttg tatcgatatc cattactctt gtcctttcca agcgtcgttc atctgtttca
      781 ctgctgactc tacgaaggtg tctaagtctt tgtcagtcat gctaatattg tattttgtaa
      841 gctcagcacg aattttagcg cgagcctgtg ccagtttttc atctcccttg tagccagttt
      901 cagcagctac ctgctccacg gcatttactg catttttggc caagatttca acaatcttga
      961 tggtcttttc tccacctttt tgaaccaggt agtccttgac tgccctaact acaacccctg
     1021 ccaaaacgac taggatgctg attgctccat tagtaatgat ttcagtaatt tgttgcattt
     1081 gttattctcc tttttcgatt tcttccatgc ggtcgttcat gcgaaccatt tctttttgaa
     1141 tgtctccgac cgcgtgagtg attgtggtta attctgtagt ggtcttttct aggtgagtca
     1201 tcaaacgctc ttctcgtcta ttagagtcgg cctttgattg ctcgtgcaaa tccataatct
     1261 tcttctctcg cttgtccgaa gtcttgataa gatatcgaat gataataaag aaaagcaaga
     1321 taaacaaaat cgcccaagct acctgacttt gagcgatttt ttcagcttct tcaattggca
     1381 tacacacctc ctattcttta ggttttaccg ttggatccgt ccagtcagga ttgccctctg
     1441 catcaaattt catgatatag aattcatgat tcaacagaac ggctacgttg attgttgcga
     1501 ttgtaccacc ccactggttg aacgcccaaa cggtttcaac atcctttaat tggcgacggc
     1561 catttacgat cacaggacgt ttttgaacat cacgatacat atagaagtca tcgcttacat
     1621 tcttgcaacg aatgaa
//
LOCUS       DAVLHC010000125         1606 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.126, whole genome shotgun sequence.
ACCESSION   DAVLHC010000125 DAVLHC010000000
VERSION     DAVLHC010000125.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1606)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1606)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1606
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.126"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..>1606
                     /locus_tag="VXE25_002182"
     CDS             <1..>1606
                     /locus_tag="VXE25_002182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000339662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="peptidase S74"
                     /protein_id="HEV0772562.1"
                     /translation="GQRQEALQRYTREESTRQATAVRELVNRDFVGKATYQEDVKGIN
                     QRIEAVKTSANKDIASQIASYRQSVDGKFTDISSQITTYKQDVGGQISGLSNRLTSSE
                     QGTTTQISNISNRINSNKQGTDNQISNLKTQVATNKDNAERQMGRISDQVSANKANAD
                     SQFANVTNQLVRKVETTDFQRVKETSKLYERILGNTENGIADKVARMALTNQLFQVEV
                     GKYSVSGPNLIKNSDFKNATNEWGSTQNLGRLVKHSFYHNGQKDLMRLSNATKNENFL
                     YSYRFNLERNTDYVLNFRGFNNSALASYDVYILGRRAGESDGFTIVKKVVSSKKLSTS
                     RCEDVSVTFNSGEMDNAYIRFDNNGSSSGTADLYITEVDLYKGYKPRTWQPHPEDAVA
                     DANKKLEATQTKMTQLAGSWAVQNINSAGDIISGINLGANGHNRFVGKLTHITGETLI
                     DRAVIKSAMVDKLKTGNFEAGSVTTTILDAEAVTAEKLKVDDALIKKLTATDAFIDQL
                     ISKRIFSIKVESVISSSTFLEAYQGR"
BASE COUNT          539 a          295 c          355 g          417 t
ORIGIN      
        1 acggtcagcg acaggaagcc ctacagcgct atactcgtga ggagagcacg agacaagcga
       61 cagcagtccg tgagctggtc aatcgtgatt tcgttggtaa ggctacttat caagaagatg
      121 ttaagggtat caatcagagg attgaagctg ttaaaactag tgcgaataaa gacatcgcta
      181 gtcaaatcgc tagctatcgt caatctgtag atggtaagtt cacggatatt tcaagtcaga
      241 taactactta taagcaagat gtgggcggtc aaatcagtgg tctatcaaat agacttacaa
      301 gcagtgagca aggaaccact actcagattt caaatatttc aaatcggata aacagtaata
      361 agcaaggcac agataatcag atttcaaatt taaagactca ggtcgctaca aacaaggata
      421 atgctgaacg acaaatgggt agaatatctg atcaggtttc tgcaaacaaa gcgaatgctg
      481 atagtcaatt tgcgaatgtg accaatcaac tagtgcgaaa agtagagact actgacttcc
      541 agcgtgttaa ggaaaccagt aaactttacg agcggatttt gggcaatact gaaaatggaa
      601 ttgcggataa ggttgctcgc atggctctga ccaatcaact atttcaggtt gaggttggga
      661 aatatagtgt aagcggccct aacctcatta agaatagtga ttttaaaaat gctacgaatg
      721 aatggggctc aactcaaaat ttaggaagat tggttaagca tagcttttat cacaacgggc
      781 agaaagacct tatgcgttta agtaatgcaa ctaaaaacga aaactttttg tatagttacc
      841 gttttaatct tgaacgaaat actgactatg tactgaattt tagaggattt aacaacagtg
      901 ctctagcaag ctatgatgtt tatattttgg gacgaagagc aggcgagagc gatggattca
      961 caatcgttaa gaaagttgtt agcagcaaga aactatctac ctctagatgc gaagatgtct
     1021 cagtaacttt taattccgga gaaatggata atgcttacat tcgttttgat aacaatggct
     1081 catcatcagg aacagctgat ttgtatatta cagaagttga cttgtacaaa ggttataaac
     1141 ctagaacatg gcaaccacat ccagaagatg cagtcgcaga tgcgaataag aagcttgaag
     1201 caacgcaaac aaaaatgact caactagctg gctcatgggc agttcaaaac atcaactcgg
     1261 ctggagatat catctctgga atcaatcttg gcgccaatgg acataaccgc tttgttggga
     1321 aattgaccca catcactgga gagaccctga ttgacagagc agtcatcaag tctgccatgg
     1381 ttgataagct caaaacgggc aattttgaag ctggttcggt cacgactacg atattagacg
     1441 ctgaagcggt aactgctgag aagttgaaag ttgacgatgc gcttattaaa aaattaactg
     1501 caactgatgc ttttattgac caactgatat ctaaacgtat cttctctatt aaggttgagt
     1561 ccgtcatttc tagctcaacc ttcctagaag cctatcaagg ccgaat
//
LOCUS       DAVLHC010000126         1599 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.127, whole genome shotgun sequence.
ACCESSION   DAVLHC010000126 DAVLHC010000000
VERSION     DAVLHC010000126.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1599)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1599)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1599
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.127"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            182..922
                     /locus_tag="VXE25_002183"
     CDS             182..922
                     /locus_tag="VXE25_002183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000356590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0772563.1"
                     /translation="MDKDYILKVKGLYHQFLLGNNKTLQVLKNVSLSASRGEFISILG
                     ISGSGKSTLLKCISSLLEPTSGEVILNGINPYKIRNAKLSSIRRNEVSFIFQAYNLIP
                     SLPVIENIALPLRLSQKKLTIKNVENLLKRMKFNAGLNDFVGTLSGGEQQKVAIARAV
                     IADSDIIFADEPTGALDSVSREVIFELLRELVGAGKCVIMVTHDIELASKTDRALILK
                     DGKIFKELHRPSGEELYKILEVQSTTEE"
     gene            925..>1599
                     /locus_tag="VXE25_002184"
     CDS             925..>1599
                     /locus_tag="VXE25_002184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000945307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HEV0772564.1"
                     /translation="MLRLVYYQFLHNKKQWLGVSPVIFVSSLVMGLAVNGVINVENNS
                     QVFVGLPDPKPIFMFPIVFGGVTLFFVLSNIINMLVEIFRDDYELLEVLGASRLQLSF
                     LVGGQIFIISSIISFIAYLCSIFVTSNYYYFLQYFFGENILPDIQFQTSAVGCIITVV
                     LISFLAFLSGCFYTFKKIRNRKSSKIRHVLSIVKRILLLAGFSVIWLLSLQQIFQDST
                     ILAKAQI"
BASE COUNT          530 a          208 c          309 g          552 t
ORIGIN      
        1 acgaaatatc agctaattta gataatgata attcaaattc catacatgat attctgttca
       61 atttaggtat ttcatttatt gaagtttcac atcattatga cttaaatgac aagagataca
      121 ctgatatata taaattggaa aatggaacac ttttcaaaat taagtgattg gaggcaagaa
      181 tatggataaa gattatatat taaaagtgaa agggctgtat catcaatttt tactaggaaa
      241 taataaaacg ttgcaagtgc tgaaaaatgt ttctctttct gcttcgagag gagaatttat
      301 aagtattcta ggaattagtg gttctggaaa gtcaacttta ttaaaatgta tttctagttt
      361 gcttgaacca acaagtgggg aagtaatttt aaatggaatc aacccctata aaatcagaaa
      421 tgcaaaattg tcaagtataa gacgtaacga agtatctttt atatttcaag catacaattt
      481 aataccttcc ctgccggtaa tagaaaatat agcacttcct ttgcgattat cacaaaaaaa
      541 attaactatt aaaaatgtag aaaacttact caaaagaatg aagtttaatg ctggcttaaa
      601 cgattttgtt ggaactctgt ctggtggaga acaacagaag gttgctatag ctagagcggt
      661 tattgctgat agtgatataa tatttgctga tgagccaact ggggctttag acagcgtttc
      721 tcgtgaagta atttttgaat tattgagaga gttagtaggg gcgggtaagt gtgtaattat
      781 ggtaacgcac gatatagaat tggcctcgaa aactgatcgt gcattaatat tgaaagatgg
      841 aaaaattttc aaagaacttc atagacctag cggggaagag ttgtataaaa tcttagaggt
      901 acaatcaact acggaggaat agagatgctc agattagttt actatcaatt tttacataat
      961 aagaaacaat ggttaggcgt ttcaccagta atttttgttt cgagtttagt tatgggattg
     1021 gctgttaatg gggtaattaa tgttgagaat aattcgcaag tatttgtcgg acttccagat
     1081 cctaaaccaa tttttatgtt tccgatagta ttcggaggag taacattatt ctttgtgctc
     1141 tctaacataa taaatatgtt ggttgaaatt tttagagatg attacgaact tctggaggtg
     1201 ttgggagcaa gtcgccttca actatcattt cttgtggggg gacagatttt tatcatttcc
     1261 tcgattatta gttttattgc atatctatgc tctatatttg ttacgtcaaa ttattattat
     1321 tttttacaat actttttcgg ggaaaatata ttacctgata tccaatttca aacgagtgct
     1381 gttggatgta tcattacagt agtgttgatt tcatttttag cctttctaag tggttgcttt
     1441 tatacgttca agaagattag aaataggaag agttctaaaa taaggcatgt tctttcaata
     1501 gtaaaaagaa tactgctatt ggctggtttt agtgttatct ggttgctttc tttgcaacaa
     1561 attttccaag atagcacaat tttagcgaag gcccagata
//
LOCUS       DAVLHC010000127         1565 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.128, whole genome shotgun sequence.
ACCESSION   DAVLHC010000127 DAVLHC010000000
VERSION     DAVLHC010000127.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1565)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1565)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1565
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.128"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..>1565
                     /locus_tag="VXE25_002185"
     CDS             <1..>1565
                     /locus_tag="VXE25_002185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000417187.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="peptidase M26"
                     /protein_id="HEV0772565.1"
                     /translation="YTPNTLLHDYSNIVDNVLTDLNSVQYDSNAIKKILDISDKVKNT
                     ELYLDEQFVKTKANIKDTLSKLLSADAAIAENSNSIIDNYVIQKIKQNKEALLLGLTY
                     LERWYNFKYGETKAKDLVMYHLDFFGKSNSSALDNVIQLGKSGFNNLLAKNNVITYNV
                     LLSKNYGTESLFKALEGYRKVFLPTTSNNEWFKAQTKAYIVEEKSSIPEVSKKQSEQG
                     TKYSIGIYDRLTSPSWKYQSMVLPLLTLPEEKTVFMIANISTIGFGAYDRYRSKVHPK
                     GDNLNKFVEDNVREAAKRFRDHYDYWYKILEPENREKLYRSLLVYDAFKFGRDNTEDK
                     VTYQADFETDHPAIKYFFGPAGNNVVHNGHGAYATGDAFYYMAYRMLDKDGAVTYTHE
                     MTHNSDREIYLGGYGRRSGLGPEFYAKGLLQAPDHPYDPTITINSVLKYDDSENSTRL
                     QVADPTQRFNSAEDLHNYMHNMFDLIYTLEILEGRAVAKLDYNAKNDLLRKIENKYKQ
                     DPDGNSVYATNVV"
BASE COUNT          615 a          195 c          266 g          489 t
ORIGIN      
        1 atatactccc aatactctat tgcatgacta cagtaatatt gtagataatg ttttaactga
       61 cttgaattct gtacaatatg attcaaatgc aattaagaaa atattagata tctcagataa
      121 agttaaaaat acggaattat acttagatga gcaatttgtt aaaacaaaag caaatataaa
      181 agatacttta tcaaaacttc tgtcagcgga tgcagcaatc gctgagaata gtaattcgat
      241 aattgataat tatgttattc agaaaatcaa acagaataaa gaagctttat tgttaggatt
      301 aacatactta gagcgttggt acaattttaa atatggtgaa acgaaagcaa aagatttagt
      361 tatgtatcac ttggatttct tcggtaaatc taatagttct gcattagata atgttattca
      421 attaggtaaa tctggattta acaatttact agcaaaaaat aatgtaatta cttacaatgt
      481 attattatct aaaaattatg gaactgaaag tttatttaaa gcattagaag gatatagaaa
      541 agtattctta ccaacaactt ctaacaatga gtggtttaaa gctcaaacta aagcatatat
      601 tgttgaagaa aaatcttcta ttccagaagt aagtaaaaaa caatcagaac aaggaactaa
      661 gtattctata ggaatttatg atagattaac tagtccgtca tggaaatatc aaagtatggt
      721 cttaccacta ttaactttac ctgaagaaaa aacagtattt atgatagcga atatttcaac
      781 aataggattt ggtgcttatg atagatatag aagtaaagtc catcctaaag gagataactt
      841 aaataaattt gtagaagaca atgtaagaga agctgcaaaa agatttagag atcattatga
      901 ttattggtat aaaatattag agcctgagaa tagagagaaa ctttatagaa gtttattagt
      961 atacgatgca tttaaatttg gtcgagataa tactgaagat aaagtaactt atcaagctga
     1021 ttttgaaact gatcatccag ctataaaata cttctttgga cctgcgggga ataatgttgt
     1081 tcataatgga cacggagcat atgctaccgg agatgcattc tattatatgg catatcgtat
     1141 gttggataaa gatggagctg taacatatac tcatgaaatg acacataact ctgatagaga
     1201 aatttatctt ggaggatatg gaagaagaag cggattaggg cctgagtttt atgctaaggg
     1261 cttattacaa gcacctgacc acccatatga tccaacaata acaattaact ctgtgttgaa
     1321 atatgatgat tcagaaaatt caacaagact tcaagtagct gatccaactc aacgatttaa
     1381 tagtgcagaa gacctacata attatatgca taatatgttt gatttaatat atactcttga
     1441 aatattagaa ggtcgtgctg tagctaaatt agattataat gcgaaaaatg atttattaag
     1501 aaaaattgag aataaatata agcaagatcc agatggtaat tctgtttatg cgacaaatgt
     1561 tgttc
//
LOCUS       DAVLHC010000128         1550 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.129, whole genome shotgun sequence.
ACCESSION   DAVLHC010000128 DAVLHC010000000
VERSION     DAVLHC010000128.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1550)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1550)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1550
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.129"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            224..1402
                     /locus_tag="VXE25_002186"
     CDS             224..1402
                     /locus_tag="VXE25_002186"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000175872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family transcriptional regulator"
                     /protein_id="HEV0772566.1"
                     /translation="MTLSKKQLQLRAKILETVYTLGPISRIEIATKTGITPATTSSIT
                     NDLIKENILLELGEDEHDTSVGRKKILLDIQAKRFYYIGCELSEKHFTFALGDNLGNI
                     LKEEKEIVTKQLIQEKGNQLINQTLKQFLNNCSDYEIEAIGIALPGRYLDNYKITTNN
                     PLWQHIDLEMIQSHFDKPLFFSNNVNCMAIGKRLFSRQQNDPNFAYFHFARGMHCSYI
                     YDGNIYGKGNLMIGEIGHTVVSSEGEECSCGRKGCLQTFAGESWLIKKSKILYHQSPY
                     SLLPSLVKNADDIDIQVILTAYQLGDTGIITLIHQALLYLSQTILNISMMIDSQKIYL
                     HSPLLTNQHIIQKLYSEMNYKPKLLYNRLPEVIIEPYNDFTAAHSAIALCLYHTILHS
                     "
BASE COUNT          568 a          270 c          222 g          490 t
ORIGIN      
        1 ttgacgtcaa gttgttattt gattatcttt tgttatttat attttacaac tataagaaag
       61 ccttgtcaag gatttgtgta aacatttgat tattttttat tatcaatata taataaaaag
      121 agaccagtaa gtaatgaaaa gcttaaaaag attaacatct acatttatcc atagcaaaaa
      181 atcataggat tttaagaatc tgacaactag gaagaaaact aatatgacct tatctaagaa
      241 acaattacaa ctaagagcta aaatactgga aacagtttac acattaggtc ccatttcacg
      301 aattgaaatc gctactaaaa caggaataac acctgcaaca actagcagta tcacaaatga
      361 tctgattaaa gaaaatattc tcttagaact tggtgaagac gaacacgata caagcgtagg
      421 gagaaaaaaa atcctgctag acattcaagc taaacgattt tactacattg gttgtgaact
      481 atctgaaaaa catttcactt ttgctttagg agataatcta ggaaatatct taaaggaaga
      541 gaaagaaatt gttactaaac agttaatcca agaaaaggga aatcaactca ttaaccagac
      601 actaaagcaa ttcttaaata actgctctga ttatgaaata gaagcaattg gaatcgcgct
      661 acctggtcgc tatttagata attataaaat aacaacaaac aatcctttat ggcaacatat
      721 cgacttagaa atgattcaat cccactttga taagcctttg tttttctcta acaatgttaa
      781 ctgtatggct ataggtaaac gcctatttag tcgccaacag aatgacccta attttgctta
      841 ttttcatttt gctagaggta tgcactgttc ttatatctac gacggaaaca tttatgggaa
      901 aggaaatcta atgattggag aaatagggca tacagttgtt tcatctgagg gagaagaatg
      961 tagctgcggg cgcaagggat gcttacaaac ttttgctgga gaatcttggt taatcaaaaa
     1021 atcaaaaatt ctatatcatc aatctcccta ttctctactt cctagtttag tcaaaaatgc
     1081 cgatgatatt gatatccaag ttattttaac cgcttatcaa ttaggtgaca ctggaataat
     1141 cacacttatc catcaagcct tactctatct tagtcaaacc attttaaata tcagtatgat
     1201 gattgactct caaaaaatct acctacatag tcctttacta acaaatcaac acatcatcca
     1261 aaaactatat agtgaaatga actacaaacc caaactgctc tataatcgcc tacctgaagt
     1321 cattattgaa ccttacaatg attttacagc cgcacactca gctattgcac tttgtttgta
     1381 tcatacaatt ctacattctt aattttctat tacatttaat aaataggcta aaaagaggga
     1441 gtatatcata aaaagcgaat aaacctgttt tctgaaaatc agaattctgt tttgttcgct
     1501 ttctttatat ttggaattat actcctatct cccctttttc ataatgtata
//
LOCUS       DAVLHC010000129         1537 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.130, whole genome shotgun sequence.
ACCESSION   DAVLHC010000129 DAVLHC010000000
VERSION     DAVLHC010000129.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1537)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1537)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1537
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.130"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..>1537
                     /locus_tag="VXE25_002187"
     CDS             <1..>1537
                     /locus_tag="VXE25_002187"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000639853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="carbohydrate binding domain-containing protein"
                     /protein_id="HEV0772567.1"
                     /translation="GQRQEALQRYTREESTRQATAVRELVNRDFVGKVTYQEDVKGIN
                     QRIEAVKTSANKDIASQIASYRQSVDGKFTDISSQITTYKQDVGGQISGLSNRLTSSE
                     QGATTQISNISNRINSNKQGTDNQISNLKTQVATNKDNAERQMGRISDQVSANKANAD
                     SQFANVTNQLARKVETTDFQRVKETSKLYERILGNTENGIADKVARMALTNQLFQVEV
                     AKNASNGQNLLKGTKDFSGGWKNKGANWKKHAEKYKGVDVLFKNNSWNGVGQEIDAKI
                     GEVYTFSLWMKSDWKNDTVNFYVNRNGSVEKGWGVPSETSVAITSEWKRYSFTFKITV
                     DGFIFPRVERLNQNTNLYIAGLKLEKGSYATPYTEAPEDTDEAIRSVQSQLTGSWAVQ
                     NINSAGDIISGINLGANGHNRFVGKLTHITGETLIDRAVIKSAMVDKLKTGNFEAGSV
                     TTTILGAEAVTAEKLKVDNALIKKLTATDAFIDELISKRIFSIKVESVISSSTFLEAY
                     QGR"
BASE COUNT          513 a          283 c          351 g          390 t
ORIGIN      
        1 acggtcagcg acaggaagcc ctacagcgct atactcgtga ggagagcacg agacaagcga
       61 cagcagtccg tgagctggtc aatcgtgatt tcgttggtaa ggttacttat caagaagatg
      121 ttaagggtat caatcagagg attgaagctg ttaaaactag tgcgaataaa gacatcgcta
      181 gtcaaatcgc tagctatcgt caatctgtag atggtaagtt cacggatatt tcaagtcaga
      241 taactactta taagcaagat gtgggcggtc aaatcagtgg tctatcaaat agacttacaa
      301 gcagtgagca aggagccact actcagattt caaatatttc aaatcggata aacagtaata
      361 aacaaggcac agataatcag atttcaaatt taaagactca ggtcgctaca aacaaggata
      421 atgctgaacg acaaatgggt agaatatctg atcaggtttc tgcaaacaaa gcgaatgctg
      481 atagtcaatt tgcgaatgtg accaatcaac tagcgcgaaa agtagagact actgacttcc
      541 agcgtgttaa ggaaaccagt aaactttacg agcgaatttt gggcaatact gaaaatggaa
      601 ttgcggataa ggttgctcgc atggctctga ctaatcaact gtttcaggtt gaggtggcta
      661 aaaatgccag caatggtcaa aatttgttga aaggcacaaa agacttctca gggggttgga
      721 aaaacaaggg tgcaaattgg aaaaagcacg ctgaaaaata caaaggtgtt gatgtcctat
      781 ttaaaaataa ttcgtggaat ggcgttggac aagagattga tgcaaaaatt ggtgaagtct
      841 atacattcag cttatggatg aagagcgact ggaagaatga tacagtaaat ttctatgtaa
      901 atagaaatgg atctgttgag aaaggttggg gtgttccatc tgaaacatcg gtcgctataa
      961 caagtgaatg gaaacgttac tcatttacct tcaaaattac tgtggacggc ttcatctttc
     1021 ctcgtgtaga acgacttaat caaaatacaa atctatatat tgcaggtctt aaacttgaaa
     1081 aaggatcgta tgcaacaccg tacaccgaag ctcctgaaga cacggacgaa gcgattcgct
     1141 ctgttcaaag ccaactaact ggctcatggg cagttcaaaa catcaactcg gctggagata
     1201 tcatctctgg aatcaatctt ggcgccaatg gacataaccg ctttgttggg aaattgaccc
     1261 acatcactgg agagaccctg attgacagag cagtcatcaa gtctgccatg gttgataagc
     1321 tcaaaacggg caattttgaa gctggttcgg tcacgactac gatattaggc gctgaagcgg
     1381 taactgctga gaagttgaaa gttgacaatg cgcttattaa aaaattaact gcaactgatg
     1441 cttttattga cgaactgata tctaaacgta tcttctctat taaggttgag tccgtcattt
     1501 ctagctcaac cttcctagaa gcctatcaag gccgaat
//
LOCUS       DAVLHC010000130         1467 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.131, whole genome shotgun sequence.
ACCESSION   DAVLHC010000130 DAVLHC010000000
VERSION     DAVLHC010000130.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1467)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1467)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1467
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.131"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..960
                     /locus_tag="VXE25_002188"
     CDS             <1..960
                     /locus_tag="VXE25_002188"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436393.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
                     /protein_id="HEV0772568.1"
                     /translation="HQIPRIINQKIAQKLIEKISMTDIAHQLSISTSTVIRKLNDFHF
                     KHDFSCLPEIMSWDEYAFTKGKMSFIAQDFNNLNIITVLEGRTQAIIRNHFLKYDRAV
                     RCRVKIITMDMFSPYYDLARQLFPCAKIVLDRFHIVQHLSRAMSRVRVQIMNQLDRKS
                     HEYKAIKRYWKLIQQDSRKLSDKHFYRPTFRMHLTNKEILNKLLSYSQDLKHHYQLYQ
                     LLLFHFQNKEPEKFFGLIEDNLKQVHPLFQTVFKTFLKDKEKIVNALQLHYSNAKLEA
                     TNNLIKLIKRNAFGFRNFENFKKRIFIALNIKKERTKFVLSRA"
     gene            complement(1164..>1467)
                     /locus_tag="VXE25_002189"
     CDS             complement(1164..>1467)
                     /locus_tag="VXE25_002189"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000458188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase family
                     protein"
                     /protein_id="HEV0772569.1"
                     /translation="ATGWLQYNGSWYYLNSNGAMVTGWLQNNGSWYYLNANGSMATDW
                     VKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGSGALAVNTTVDSYRVNANGEWVN"
BASE COUNT          448 a          310 c          246 g          463 t
ORIGIN      
        1 caccaaatcc ctcgtatcat caaccaaaag attgctcaaa agttaattga aaagatttct
       61 atgactgata ttgcccatca gctttccatc tcaacttcaa ctgttattcg taagctcaat
      121 gactttcact ttaaacatga tttttcttgt cttcctgaga ttatgtcttg ggatgagtat
      181 gcttttacaa agggaaagat gagcttcatt gcgcaagatt ttaacaatct caatatcatc
      241 actgttcttg agggaagaac acaagctatc attcgaaatc actttcttaa atatgataga
      301 gccgtccgat gtcgcgtcaa aattattact atggatatgt ttagtcctta ctatgactta
      361 gctagacaac ttttcccatg tgctaaaatc gtgttggatc gctttcacat tgtacaacat
      421 cttagccgtg ctatgagtcg tgtgcgtgtt caaatcatga atcaattgga tcgaaagtct
      481 catgaataca aggctatcaa gcgctactgg aagctcatac aacaggatag tcgtaaactc
      541 agcgataaac atttttatcg ccctactttt cgtatgcatt taaccaataa agagatttta
      601 aacaagcttt tgagctattc acaagacttg aaacatcact atcagctcta tcaactcttg
      661 ctgtttcact ttcagaataa ggaaccggag aaatttttcg gactcattga ggacaatcta
      721 aagcaggttc atcctctttt tcagactgtc tttaaaacct ttctaaagga caaagagaaa
      781 atcgtcaacg cccttcaact acactattct aacgccaaat tggaagcgac caataatctc
      841 atcaaactta tcaagcgcaa tgcctttggt tttcggaact ttgaaaactt caaaaaacgg
      901 atttttatcg ctctgaatat caaaaaagaa aggacaaaat ttgtcctttc tcgagcttag
      961 ctgacttcaa cccactacag ttgacaaaga gccaaaaaaa actccgtagt ctctagcgct
     1021 ataaatccgg ctagagatta cagagttatt ttttaatcta aacttcctac aagggtatat
     1081 tatctactga aaggatatgg tatttgtagg gaatacttta aagagttctt acaggaagtc
     1141 agtattaact agttatatta agtttagttt acccattcac cattggcatt gactctatag
     1201 ctatctacag ttgtgttgac tgcaagggca cctgagccat tgacatagta ccatttatct
     1261 gatactttga accattggct tgctttcata gcacctgatg cttcaagata gtaccaggta
     1321 tctccatctt tcacccaatc tgttgccatt gaaccgttag cgtttaggta gtaccatgag
     1381 ccattgtttt ggagccatcc tgttaccata gcaccattgc tgtttaggta gtaccatgaa
     1441 ccattgtatt ggagccatcc tgtcgcc
//
LOCUS       DAVLHC010000131         1363 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.132, whole genome shotgun sequence.
ACCESSION   DAVLHC010000131 DAVLHC010000000
VERSION     DAVLHC010000131.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1363)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1363)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1363
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.132"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            31..870
                     /locus_tag="VXE25_002190"
     CDS             31..870
                     /locus_tag="VXE25_002190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000161411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HEV0772570.1"
                     /translation="MTKIKIVTDSSVTIEPELVKQLDITIVPLSVMIDNVVYSDADLK
                     EEGKFLQLMQESKNLPKTSQPPVGVFAEIFEDLCKDGGQILAIHMSHALSGTVEAARQ
                     GASLSTADVTVVDSSFTDQALKFQVVEAAKLAQEGKDMEAILSHVEEVKNHTELYIGV
                     STLENLVKGGRISRVTGLLSSLLNIRVVMQMKDHELQPMVKGRGTKTFKKWLDELITS
                     LSERAVAEIGISYSGSDDWAKEMKESLQAYVEKPISVLETGSIIQTHTGENAWAILIR
                     YHS"
     gene            977..1252
                     /locus_tag="VXE25_002191"
     CDS             977..1252
                     /locus_tag="VXE25_002191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002950996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HU family DNA-binding protein"
                     /protein_id="HEV0772571.1"
                     /translation="MANKQDLIAKVAEATELTKKDSAAAVEAVFAAVADYLAAGEKVQ
                     LIGFGNFEVRERAERKGRNPQTGKEMTIAASKVPAFKAGKALKDAVK"
BASE COUNT          451 a          211 c          291 g          410 t
ORIGIN      
        1 tctgaatcct aaaatagaaa gattgatact atgacaaaaa ttaagattgt aaccgattca
       61 tctgttacta ttgaacctga actagtaaag caattagata ttacaattgt tccattatct
      121 gtaatgattg ataatgttgt ttattctgat gcggatttga aagaagaagg taaatttctt
      181 cagttgatgc aagaaagtaa gaatcttccg aaaacaagtc agccccctgt aggtgtcttt
      241 gctgagattt ttgaagacct atgcaaagat ggtggccaga ttcttgctat tcatatgtcc
      301 catgctcttt cgggtacggt agaagcagca cgccaaggtg ctagcctatc tactgcagat
      361 gtgactgttg ttgatagttc cttcactgac caagccctga aattccaagt tgttgaggct
      421 gcgaagttag ctcaagaagg taaagatatg gaggcaattt tatctcatgt agaagaggtt
      481 aaaaaccata cagagcttta tattggtgtt tcaactttgg aaaatcttgt caaaggtgga
      541 cgaattagcc gtgtaactgg cttgttgagc tctcttctca atatccgtgt tgtcatgcaa
      601 atgaaagacc atgaattgca gccaatggtt aaaggtcgtg gaactaaaac atttaaaaaa
      661 tggttagatg agttgataac atcgctttct gaacgtgctg tagcagagat tggaatttca
      721 tattctggta gtgatgattg ggcaaaagag atgaaagaaa gcttacaagc ttatgttgaa
      781 aagccaattt ctgttttgga aacgggttcc attattcaaa ctcacacggg tgagaacgct
      841 tgggctattt tgatacgtta ccactcctaa aaaaataaat aaaatgggaa gaaatagcgt
      901 ttttaacttg acctaaaagg gattttagga tatgattata tttgttaatt agaaattatt
      961 tggaggaatc attaacatgg caaacaaaca agatttgatc gctaaagtag cagaagctac
     1021 agaattgact aagaaagact cagcagcagc agttgaagct gtatttgcag cagtagctga
     1081 ctatcttgca gctggtgaaa aagttcagtt gatcggtttt ggtaactttg aagttcgtga
     1141 gcgtgcagaa cgtaaaggtc gcaacccaca aactggtaaa gaaatgacaa ttgcagcttc
     1201 taaagtacca gcattcaaag ctggtaaagc tcttaaagac gctgttaaat aatcagtctt
     1261 taaaaagcct attgtatcaa gctttctagc ttggtcagta ggctttttaa ttatgaaatc
     1321 tagtaataaa tagagttaaa aagttgaatg ttccgaaaat att
//
LOCUS       DAVLHC010000132         1333 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.133, whole genome shotgun sequence.
ACCESSION   DAVLHC010000132 DAVLHC010000000
VERSION     DAVLHC010000132.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1333)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1333)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1333
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.133"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(<1..494)
                     /locus_tag="VXE25_002192"
     CDS             complement(<1..494)
                     /locus_tag="VXE25_002192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000687786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEV0772572.1"
                     /translation="MKIENESKSYDKCILKNISLEIDKGIYRVEGENGSGKSTLLQLL
                     AGLETFDSGLKNCVSKDVLYLDTNQLGVVPFTIEENLQLLCDSFQIHLSFEDKEQINT
                     FFDNKIGDNYMTASTGTKFKLGLSLIFAKNWDYIFIDETLSTVDARSIDMIAKRLISM
                     KESST"
     gene            complement(491..973)
                     /locus_tag="VXE25_002193"
     CDS             complement(491..973)
                     /locus_tag="VXE25_002193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001232094.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage II sporulation protein M"
                     /protein_id="HEV0772573.1"
                     /translation="MRKSGFLIYYVLFCIVCFLLGLLLSFILKNETFATIPPKLELQF
                     TLTVLQANSTNFLLYLFCFPISPLLQLFDLLSLGIQLGISGQMIGIVATIKGILPHAL
                     IEIPNFIWYQGMSQYLLYRLLKDRGIKNILIYIKSNLKWYIISYLLLILAALIEGIKL
                     "
BASE COUNT          518 a          222 c          157 g          436 t
ORIGIN      
        1 gtagagcttt ctttcatgga aattaagcgt ttagcaatca tatcaatact tcttgcatcc
       61 actgttgata aagtctcatc aataaaaata taatcccaat ttttagcaaa aattaaggat
      121 aagcctaatt tgaattttgt tccagtagat gctgtcatat agttatctcc gattttatta
      181 tcaaaaaaag tattaatttg ttctttatcc tcaaatgata gatggatttg aaaagaatca
      241 cacaacaact gcaaattttc ttctatagta aatggaacaa ccccaagctg attggtatca
      301 aggtatagta catctttgga gacacaattc tttaaaccac tatcaaaagt ctctagccca
      361 gctaaaagtt gtagaagggt gctctttcct gaaccattct ctccttcaac tctgtaaatt
      421 cccttatcaa tctctagtga tatatttttc aatatacatt tatcataact tttagattca
      481 ttttcaattt tcataattta attccctcta tcaacgctgc taaaattaat aaaagataag
      541 aaatgatata ccattttaaa ttacttttta tataaataag tatattttta attcccctat
      601 ccttcaataa tcggtataaa agatactgac tcataccttg ataccaaata aaattcggta
      661 tttcaataag agcatgaggt aatattcctt ttattgtagc tactattcca atcatctgac
      721 cagatatacc caattgtatt cctaaagata gcaaatcaaa aagttgcaat aagggcgaaa
      781 tcggaaaaca gaatagatat agcaaaaaat ttgtagaatt tgcctgtaaa actgtcaatg
      841 taaattgtaa ttccagtttc ggaggtatag tagcaaaagt ctcatttttt aatataaagc
      901 ttaaaagtaa acctagtaaa aaacagacta tacaaaataa cacatagtaa atcagaaaac
      961 cactttttct catctaatgc cccctactaa aattacaaat attatcagaa aacaatataa
     1021 aaccagaaaa ctccatctca ataaactaac tgtaccttta attaaaaata gagctttctt
     1081 ataatagaca taggctataa aataattgaa tggaatcaat aacaaattca acaaaatact
     1141 ttttatatca ttactataac ttgtcaccgg aatcaaacat aacaacaatg aaaattgtaa
     1201 gaaagagatt aaatgcgtca acatcattag ttgtgcattc ttaaaaaaga aattcatttt
     1261 agaatgatta agagcagata attgaagtaa agctagatct accccaattg aggatttatg
     1321 attccctatt att
//
LOCUS       DAVLHC010000133         1186 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.134, whole genome shotgun sequence.
ACCESSION   DAVLHC010000133 DAVLHC010000000
VERSION     DAVLHC010000133.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1186)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1186)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1186
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.134"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..>1186
                     /gene="phtD"
                     /locus_tag="VXE25_002194"
     CDS             <1..>1186
                     /gene="phtD"
                     /locus_tag="VXE25_002194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="pneumococcal histidine triad protein PhtD"
                     /protein_id="HEV0772574.1"
                     /translation="LIFDPAQITSRTARGVAVPHGNHYHFIPYSQMSELEERIARIIP
                     LRYRSNHWVPDSRPEQPSPQSTPEPSPSPQSAPNPQPAPSNPIDEKLVKEAVRKVGDG
                     YVFEKNGVSRYIPAKNLSAETAAGIDSKLAKQESLSHKLGAKKTDLPSSDREFYNKAY
                     DLLARIHQDLLDNKGRQVDFEALDNLLERLKDVPSDKVKLVDDILAFLAPIRHPERLG
                     KPNAQITYTDDEIQVAKLAGKYTTEDGYIFDPRDITSDEGDAYVTPHMTHSHWIKKDS
                     LSEAERAAAQAYAKEKGLTPPSTDHQDSGNTEAKGAEAIYNRVKAAKKVPLDRMPYNL
                     QYTVEVKNGSLIIPHYDHYHNIKFEWFDEGLYEAPKGYTLEDLLATVKYYVEHPNERP
                     HS"
BASE COUNT          379 a          262 c          246 g          299 t
ORIGIN      
        1 gccttatttt cgacccagcg caaatcacaa gtcgaaccgc cagaggtgta gctgtccctc
       61 atggtaacca ttaccacttt atcccttact ctcaaatgtc tgaattggaa gaacgaattg
      121 ctcgtattat tccccttcgt tatcgttcaa accattgggt accagattca agaccagaac
      181 aaccaagtcc acaatcgact ccagaaccta gtccaagtcc gcaatctgca ccaaatcctc
      241 aaccagctcc aagcaatcca attgatgaga aattggtcaa agaagctgtt cgaaaagtag
      301 gcgatggtta tgtctttgag aagaatggag tttctcgtta tatcccagcc aagaatcttt
      361 cagcagaaac agcagcaggc attgatagca aactggccaa gcaggaaagt ttatctcata
      421 agctaggagc taagaaaact gacctcccat ctagtgatcg agaattttac aataaggctt
      481 atgacttact agcaagaatt caccaagatt tacttgataa taaaggtcga caagttgatt
      541 ttgaggcttt ggataacctg ttggaacgac tcaaggatgt cccaagtgat aaagtcaagt
      601 tagtggatga tattcttgcc ttcttagctc cgattcgtca tccagaacgt ttaggaaaac
      661 caaatgcgca aattacctac actgatgatg agattcaagt agccaagttg gcaggcaagt
      721 acacaacaga agacggttat atctttgatc ctcgtgatat aaccagtgat gagggggatg
      781 cctatgtaac tccacatatg acccatagcc actggattaa aaaagatagt ttgtctgaag
      841 ctgagagagc ggcagcccag gcttatgcta aagagaaagg tttgacccct ccttcgacag
      901 accatcagga ttcaggaaat actgaggcaa aaggagcaga agctatctac aaccgcgtga
      961 aagcagctaa gaaggtgcca cttgatcgta tgccttacaa tcttcaatat actgtagaag
     1021 tcaaaaacgg tagtttaatc atacctcatt atgaccatta ccataacatc aaatttgagt
     1081 ggtttgacga aggcctttat gaggcaccta aggggtatac tcttgaggat cttttggcga
     1141 ctgtcaagta ctatgtcgaa catccaaacg aacgtccgca ttcaga
//
LOCUS       DAVLHC010000134         1161 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.135, whole genome shotgun sequence.
ACCESSION   DAVLHC010000134 DAVLHC010000000
VERSION     DAVLHC010000134.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1161)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1161)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1161
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.135"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            17..1042
                     /locus_tag="VXE25_002195"
     CDS             17..1042
                     /locus_tag="VXE25_002195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000790748.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-siderophore ABC transporter
                     substrate-binding protein"
                     /protein_id="HEV0772575.1"
                     /translation="MKNKFFLIAILAMCIVFSACSSNSVKNEENTSKEHAPDKIVLDH
                     AFGQTILDKKPERVATIAWGNHDVALALGIVPVGFSKANYGVSADKGVLPWTEEKIKE
                     LNGKANLFDDLDGLNFEAISNSKPDVILAGYSGITKEDYDTLSKIAPVAAYKSKPWQT
                     LWRDMIKIDSKALGMEKEGDELIKNTEARISKELEKHPEIKGKIKGKKVLFTMINAAD
                     TSKFWIYTSKDPRANYLTDLGLVFPESLKEFESEDSFAKEISAEEANKINDADVIITY
                     GDDKTLEALQKDPLLGKINAIKNGAVAVIPDNTPLAASCTPTPLSINYTIEEYLNLLG
                     NACKNAK"
     gene            1032..>1161
                     /locus_tag="VXE25_002196"
     CDS             1032..>1161
                     /locus_tag="VXE25_002196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001244688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HEV0772576.1"
                     /translation="MRNKKQINLGIIFVICLGLLITIFLSLKLGTKEINIRDFLAAF"
BASE COUNT          448 a          160 c          195 g          358 t
ORIGIN      
        1 tgtttaagga gtttttatga aaaacaaatt ttttctaata gctattttag ctatgtgtat
       61 agtttttagc gcttgttctt ctaattctgt taaaaatgaa gaaaatactt ctaaagagca
      121 tgcgcctgat aaaatagttt tagatcatgc tttcggtcaa actatattag ataaaaaacc
      181 tgaaagagtt gcaactattg cttggggaaa tcatgatgta gcattagctt taggaatagt
      241 tcctgttgga ttttcaaaag caaattacgg tgtaagtgct gataaaggag ttttaccatg
      301 gacagaagaa aaaatcaaag aactaaatgg taaagctaac ctatttgacg atttggatgg
      361 acttaacttt gaagcaatat caaattctaa accagatgtt atcttagcag gttattctgg
      421 tataactaaa gaagattatg acactctatc aaaaattgct cctgtagcag catacaaatc
      481 taaaccttgg caaactttat ggagagatat gattaaaatt gattcaaaag ccttaggtat
      541 ggaaaaagaa ggtgatgagt taatcaaaaa tactgaagct cgtatatcca aagaattaga
      601 aaaacatcca gaaatcaaag gaaaaatcaa aggaaaaaaa gtattattta ctatgattaa
      661 tgctgcagat acatcaaaat tctggattta tactagcaaa gatccaagag caaattattt
      721 aacagattta ggtctagttt tccctgaatc attaaaagaa tttgagagtg aagatagttt
      781 tgcaaaggaa atttctgcag aagaagcaaa taagataaat gatgctgatg taatcataac
      841 ttatggtgat gataaaactc ttgaagcttt acaaaaagat cctcttttag gtaaaataaa
      901 tgcaattaaa aatggtgccg ttgctgtaat tccagataat acaccgttag cagcctcatg
      961 cactccaaca ccactttcaa taaactatac tattgaagaa tacctaaatc ttttaggaaa
     1021 tgcatgcaaa aatgcgaaat aaaaaacaaa taaacctagg cataattttt gtaatctgcc
     1081 taggtcttct tattacaata tttttgtcat taaagcttgg aacaaaagaa attaatatca
     1141 gagatttttt agcagctttt g
//
LOCUS       DAVLHC010000135         1097 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.136, whole genome shotgun sequence.
ACCESSION   DAVLHC010000135 DAVLHC010000000
VERSION     DAVLHC010000135.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1097)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1097)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1097
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.136"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..>1097
                     /locus_tag="VXE25_002197"
     CDS             <1..>1097
                     /locus_tag="VXE25_002197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0772577.1"
                     /translation="SIISVLSNDLRLIEENYFRQIFEIISSILLFIVSLSFMLYLNFL
                     VSIIFIVLSALPIIVPVFMKKMLSNSANEYSNSNAEYTHIIKEIFNGFKTLKSYSVTK
                     EIISLSDKKLDKLEDSTFNLKRSEVLSKLVAVLISGFCFLVPLVVGCYFVIYHKSLSF
                     SELIGIFLANDKVLGPIQSIAYSLNKINTTKDLRKPFLKYLSGEKNFIDAEHDNNGLY
                     TSSIDEIHMKDVVYSITPENKLSIDFSFKSPFRVLLTGTSGSGKTTILNLINGSLKPQ
                     KGYVNLLSHGKKSSDSIPTVDQTPYIFDTTIRENVTLFQNEYFSDDQIIEVLKKVNLY
                     EELEKIDILNYQCGENGSNLSGGQKQKIALA"
BASE COUNT          397 a          134 c          174 g          392 t
ORIGIN      
        1 tctattattt cagttttgtc aaatgatttg agattaatcg aagaaaacta ttttagacaa
       61 atttttgaaa taatttcttc aatattgttg ttcatcgtct ctctaagttt tatgctttat
      121 ttaaacttcc tagtttcaat aatatttatt gtattatcag cattgccgat tatagtacct
      181 gtctttatga agaagatgtt gtctaattca gctaatgagt actctaacag caatgcagag
      241 tatactcaca taataaaaga aatttttaat ggttttaaga cattaaaatc ttattctgtt
      301 actaaagaaa taattagttt gtcggataaa aagttggata aactagaaga ttctactttt
      361 aatttgaaac gatcagaggt tctttcaaaa ttggttgcag tactaatttc aggtttttgc
      421 tttctagttc ccttggttgt aggatgttat tttgtaattt atcataaaag cctttctttt
      481 agtgaactga taggtatttt cttagcaaac gataaagttt tagggccgat acaatcaatt
      541 gcctattcat taaataagat aaatacaacc aaagatttaa ggaaaccgtt tttaaaatac
      601 ttaagtggag agaagaattt tatagacgct gaacatgata ataacggact gtatacttca
      661 tcaatagatg agatacacat gaaagatgtt gtatattcta ttacaccaga aaataaatta
      721 agtattgact tctcatttaa gtcaccattt agggtattat taacaggaac ttctggtagt
      781 gggaaaacaa cgattttaaa tttaattaat ggttctttaa agccacaaaa aggttatgta
      841 aatttgttat cacatgggaa aaagagttca gattcaatac caacagttga tcagacacca
      901 tatatttttg acactactat tcgtgagaac gtaactttat ttcaaaatga atatttttca
      961 gatgatcaga taattgaggt gttaaaaaag gtaaatctat atgaagaatt agaaaagata
     1021 gatatactaa attatcaatg tggtgaaaat ggtagtaatt tgtctggagg tcaaaaacaa
     1081 aaaatagctt tagctag
//
LOCUS       DAVLHC010000136         1089 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.137, whole genome shotgun sequence.
ACCESSION   DAVLHC010000136 DAVLHC010000000
VERSION     DAVLHC010000136.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1089)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1089)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1089
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.137"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..94
                     /locus_tag="VXE25_002198"
     CDS             <1..94
                     /locus_tag="VXE25_002198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004264816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="SapB/AmfS family lantipeptide"
                     /protein_id="HEV0772578.1"
                     /translation="DETDEVDGMRFSTFSTNRCGNWSAFSWENC"
     gene            715..>1089
                     /locus_tag="VXE25_002199"
     CDS             715..>1089
                     /locus_tag="VXE25_002199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEV0772579.1"
                     /translation="MNSLPNHHFQNKSFYQLSFDGGHLTQYGGLIFFQELFSQLKLKE
                     RISKYLVTNDQRRYCRYSDSDILVQFLFQLLTGYGTDYACKELSADAYFPKLLEGGQL
                     ASQPTLSRFLSRTDEETVHSLRC"
BASE COUNT          320 a          186 c          217 g          366 t
ORIGIN      
        1 tgacgaaaca gatgaagttg atggaatgcg atttagtaca ttcagtacaa accgttgcgg
       61 taactggagt gcttttagtt gggaaaattg ttaattcatt taaattgtaa actttagaga
      121 ttctctggag ttatggatgt cgttccaata tgtgcacgtt ggaatgttag tgcttatatg
      181 gggggaacag aatcctctct tgattgaaga caagctagtc attaggctgg tttgtctttt
      241 tgtcaactgt agtgggttga tataatagta ttagtgagtg ggataaaagt ttcatttagt
      301 ttattcagta caaatttaac gggtcaagat ttatatacta gtggtgtttt tggggctgag
      361 agaagtatct tgattttatg tgtggttttt atacttacag ttgttctgct ccaaagagct
      421 tgtagagaag aattagctca taaaggagat tgattatttt gatatcaaaa aaatgcacag
      481 gataacctga tgcatttttt tagcgacaat gcttgctact tccttctgtc gaatttagac
      541 aattttaaac cccaattatt caccccaaat ctaaaaacca tccagaatcc ttgccttagc
      601 ttagatcctg gatggtttct tttttcaccc aatgggtgtt ttttactaga caaaaaagag
      661 tttccccttt atggtataag tgtagaaaaa aacacaaaaa gaaaggaaac tcacatgaac
      721 agtttaccaa atcatcactt ccaaaacaag tctttttacc aactatcttt cgatggaggt
      781 catttaaccc agtatggtgg tcttatcttt tttcaggaac ttttttccca gctgaaacta
      841 aaagagcgga tttctaagta tttagtaacg aatgaccaac gccgctactg tcgttattcg
      901 gattcagata tccttgtcca gttcctcttt caactgttaa caggttatgg aacggactat
      961 gcttgtaaag aattgtcagc tgatgcctac tttccaaaat tattggaagg agggcagctt
     1021 gcttcacagc caaccttatc ccgttttctt tccagaactg acgaggaaac agtccatagt
     1081 ttgcgatgc
//
LOCUS       DAVLHC010000137         1071 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.138, whole genome shotgun sequence.
ACCESSION   DAVLHC010000137 DAVLHC010000000
VERSION     DAVLHC010000137.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1071)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1071)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1071
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.138"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(<1..140)
                     /locus_tag="VXE25_002200"
     CDS             complement(<1..140)
                     /locus_tag="VXE25_002200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2273 domain-containing protein"
                     /protein_id="HEV0772580.1"
                     /translation="MEWLKQYRYPIIAGLIGVFLACLIVSFGFFKTIFVLILGALGVA
                     AG"
     gene            complement(152..718)
                     /gene="amaP"
                     /locus_tag="VXE25_002201"
     CDS             complement(152..718)
                     /gene="amaP"
                     /locus_tag="VXE25_002201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000030212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alkaline shock response membrane anchor protein
                     AmaP"
                     /protein_id="HEV0772581.1"
                     /translation="MSKAKKICFIIFCILILTIFLPVLIDYHQVSDLGIHLLSWRQNS
                     VVEFYLARYVFWGTVVLSTLVLLSILVVMFYPKRYLEIQLETKNDTLKLKNSAIEGFV
                     RSLVSDHRLIKNPTVHVNLRKNKCFVHVEGKILPSDNIADRCQIIQNEITNGLKQFFG
                     IERQVKLEVAVKNYQPKPQNKKTVSRVK"
     gene            complement(802..966)
                     /locus_tag="VXE25_002202"
     CDS             complement(802..966)
                     /locus_tag="VXE25_002202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397534.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GlsB/YeaQ/YmgE family stress response membrane
                     protein"
                     /protein_id="HEV0772582.1"
                     /translation="MGIIANVFAGLVGAYAGQSLLGSWGPSIAGMALLPSIVGAAIVI
                     TVVSFFTGRK"
BASE COUNT          363 a          214 c          152 g          342 t
ORIGIN      
        1 aatccagctg caactcccag tgctcctaaa atcaatacaa atattgtttt gaagaagcca
       61 aaggagacaa tcaaacaagc cagaaatacg cctatgagac cagcgataat tggatatcga
      121 tattgtttaa gccattccat tttttacttc cttacttcac acgactaaca gtctttttgt
      181 tttgaggttt tggttggtaa ttttttactg caacttcaag ttttacttga cgctcaatac
      241 caaaaaactg cttcaatcca ttagttattt cattttgaat tatttggcat ctgtcagcga
      301 tgttgtctga aggaagaatt ttaccttcta catgaacgaa acatttattt tttcgtaaat
      361 ttacatgaac agttgggttc ttgatcaatc tatgatcact caccaaactt ctaacaaaac
      421 cttcgattgc cgaattcttt aattttaatg tatcgttttt agtttcaagt tggatttcca
      481 agtaacgttt aggataaaac atcacaacta aaatggataa taaaactaaa gttgatagaa
      541 ccactgtccc ccaaaagaca tatctagcaa gatagaattc aactacggag ttctgtctcc
      601 agctaagtag atgaatacct agatcactaa cttgatgata atctatcaaa acaggaagga
      661 aaattgtcaa gattaaaata cagaaaataa tgaaacatat tttctttgct tttgacatat
      721 acaatccttt cgatttaaca tttaaactat ttttcccgtc attgatttaa aaatagtttg
      781 ctaactttac tggcgaaaag tttactttct acctgtaaag aatgacacta cagtaatcac
      841 aatcgctgca cctacaatag atgggagcaa agccattcca gcgattgatg gaccccaact
      901 acctaaaaga gattgtcctg catatgcccc gactaaacca gcgaatacat ttgcgatgat
      961 tcccatagaa ctactttttt agtgatttta cctgccaaga gaccaataag acctccagca
     1021 ataattgatc acaacactgc ctaccctcct tttttatttt aatatcaaaa a
//
LOCUS       DAVLHC010000138         1060 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.139, whole genome shotgun sequence.
ACCESSION   DAVLHC010000138 DAVLHC010000000
VERSION     DAVLHC010000138.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1060)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1060)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1060
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.139"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..279
                     /gene="lytA"
                     /locus_tag="VXE25_002203"
     CDS             <1..279
                     /gene="lytA"
                     /locus_tag="VXE25_002203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase LytA"
                     /protein_id="HEV0772583.1"
                     /translation="NWYWFDNSGEMATGWKKIADKWYYFDVEGAMKTGWVKYKDTWYY
                     LDAKEGAMVSNAFIQSADGTGWYYLKPDGTMADKPEFTVEPDGLITVK"
     gene            complement(417..596)
                     /locus_tag="VXE25_002204"
     CDS             complement(417..596)
                     /locus_tag="VXE25_002204"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001209433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772584.1"
                     /translation="MREVIQELLDSSMSTSAISQGAGVPWTTVSDLRKGKTSMDKMAL
                     LTAEKLYEFATTDKQ"
     gene            complement(738..887)
                     /locus_tag="VXE25_002205"
     CDS             complement(738..887)
                     /locus_tag="VXE25_002205"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772585.1"
                     /translation="MNKEDWLRLLEKAIDNIPETVTAIASLVTAITVARQNKKRKPKS
                     RQRKR"
BASE COUNT          301 a          201 c          215 g          343 t
ORIGIN      
        1 aactggtact ggttcgacaa ctcaggcgaa atggctacag gctggaagaa aatcgctgac
       61 aagtggtact attttgatgt agaaggtgcc atgaagacag gctgggtcaa gtacaaggac
      121 acttggtact acttagacgc taaagaaggt gccatggtat caaatgcctt tatccagtca
      181 gcggacggaa caggctggta ctacctcaaa ccagacggaa cgatggcaga taaaccagag
      241 ttcacagtag agccagatgg cttgattaca gtaaaataaa tagaaaggaa actttctaaa
      301 ttgttctttc accgcaggct caggcttgcg gttttttatt tgctctgatt tttcaaaaaa
      361 gtgcttactt gaagaatagg gaggtgtttt gtcaaaaata aaaacagtga ccgaaatcac
      421 tgcttatcag ttgtagcaaa ttcataaagt ttttctgctg tgagaagtgc cattttgtcc
      481 atgcttgttt ttccttttct gaggtcagaa acagtagtcc atggaactcc agcaccttgg
      541 gaaatagcag atgtagacat cgaactgtct aacaattctt gaataacttc tctcatctta
      601 tttgtccttt ttatttttta gataaatata tacattgatt gcaattataa aaatagctat
      661 tgcactaacc attgcatttc ctctttccat ttgataaaat agaggtgtaa ggggctttcg
      721 ccccaacctc ttagcgttta cctttttctt tgacgggatt tcggtttacg ctttttgttt
      781 tgccttgcga ccgttattgc ggtcactaga cttgcgatag cagttaccgt ttcaggaata
      841 ttgtctattg ccttttcaag taacctgagc caatcttctt tgttcaactt catcaccccc
      901 tttccttatc ttgattatat tatatcacgg tacaccgaga aagtcaagcg ttttgatgaa
      961 gtttttttaa ttttttcaaa aaaaaataga ccttgtccag aggtcgggga gttggagggg
     1021 gcaccctcca aaagcattga tttaataagg ttttatttta
//
LOCUS       DAVLHC010000139         1058 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.140, whole genome shotgun sequence.
ACCESSION   DAVLHC010000139 DAVLHC010000000
VERSION     DAVLHC010000139.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1058)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1058)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1058
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.140"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(1..383)
                     /locus_tag="VXE25_002206"
                     /pseudo
     CDS             complement(1..383)
                     /locus_tag="VXE25_002206"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000169115.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="U32 family peptidase"
     gene            complement(643..954)
                     /locus_tag="VXE25_002207"
     CDS             complement(643..954)
                     /locus_tag="VXE25_002207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398245.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772586.1"
                     /translation="MIEAQGFLVDKQTRCIHYHSKLDIIALQCYDCKKYYACYRCHDS
                     LENHPFEPYPLSLIQDKPILCGVCLKLLTYKQYKESLSCLFCFSRFNPGCQNHKERYF
                     K"
     gene            complement(969..>1058)
                     /locus_tag="VXE25_002208"
     CDS             complement(969..>1058)
                     /locus_tag="VXE25_002208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000169115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="U32 family peptidase"
                     /protein_id="HEV0772587.1"
                     /translation="VQSGDMVRALKEGLINLYKEDGTSVTVRA"
BASE COUNT          327 a          215 c          174 g          342 t
ORIGIN      
        1 ttttcagatg gtgtaccata gtaaaatcct gtagccagtt cacgttgggc aaccttccac
       61 atctcgtcca ccaagtcttg tttgatagct tcaaactttt caggactttc aagataggca
      121 tccacagccg ccttgtagca gttggttact gttgatacat agtgaataga ctccatacgt
      181 ccttcgattt ttagactgtc cacaccattt tcaatcatat ctgagatatg gtcaatcata
      241 gacatatcaa cggctgacat tgaaaattct tctggaatct caccctgcaa actcttacgt
      301 tctttcccaa atggcatatc gtaaaggtcg tacttccaac ggcatgactg agaacatcca
      361 ccacggttgg catcacgcat actctagacg gattgttttg acaattctaa ccttttagac
      421 tttgcataat aactgttaaa cagtcgaaaa ttaccccagt tttaacaagt agtcaaaata
      481 ccagataaag taaaaagggg ctaggaaaaa agtctttaaa atcttaaaaa cgcatagtat
      541 caggtattga acaatcttga tattatgcgt tttattgtgg gaagatttac ttcattttct
      601 cttggaattg agttttctcc tacttcaaaa ctagatgatt tgctatttaa aatagcgttc
      661 cttatgattt tggcaacctg gattaaagcg agaaaaacaa aagaggcaac ttaagctttc
      721 tttatattgc ttatatgtta atagttttag acaaacacca cataaaatag gcttatcctg
      781 tatcaaagat aagggataag gctcaaaagg gtgattttct aatgaatcat gacaccgata
      841 acaagcataa tactttttac aatcatagca ttgtaaagca ataatatcca gcttgctatg
      901 gtaatgaatg catcttgttt gcttatccac taagaaaccc tgtgcctcta tcatttcctt
      961 ttcctttctt aagctcgaac tgtgacgctg gttccatctt ccttataaag attgatgagt
     1021 ccttctttta atgcacgaac catgtctcct gattgaac
//
LOCUS       DAVLHC010000140         1056 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.141, whole genome shotgun sequence.
ACCESSION   DAVLHC010000140 DAVLHC010000000
VERSION     DAVLHC010000140.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1056)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1056)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1056
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.141"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..559
                     /locus_tag="VXE25_002209"
     CDS             <1..559
                     /locus_tag="VXE25_002209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001220748.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HEV0772588.1"
                     /translation="NKDETTSYPIYEIPEAWRYIKFASLVNFRIGKTPPRSEATFWGT
                     EIPWVSISDMPISGYVTNTRESISKLALKSKKIDISPKGTLLMSFKLSIGKVAILDIP
                     ATHNEAIISIFPYANKENIIRDYLMIFLPLISTLGDSKDAIKGKTLNSTSISELLIPI
                     SNHEEMKRIISKVDLLFQKVSQLFE"
     gene            complement(507..1052)
                     /locus_tag="VXE25_002210"
     CDS             complement(507..1052)
                     /locus_tag="VXE25_002210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001104691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HEV0772589.1"
                     /translation="MNWVVIKIKDIFSMNTGLSYKKGDLSINNKGVRIIRGGNIKPLE
                     FSLLDNDYYIDTQFISSEQVYLKHNQLITPVSTSLEHIGKFARIDKDYDGVVAGGFIF
                     QLTPFESSEIISKFLLFNLSSPLFYKQLKAITKLSGQALYNIPKTTLSELLIPLAPFE
                     EQELITQKVEKLFEKVNQLWK"
BASE COUNT          379 a          167 c          155 g          355 t
ORIGIN      
        1 gaataaagac gaaacaacct cttatcctat atatgaaatc ccagaagcat ggagatatat
       61 taaatttgct agcctagtta acttcagaat aggaaaaact cctccacgca gtgaagctac
      121 tttttgggga actgaaatac cttgggtatc tatatcagat atgcctatat ctggttatgt
      181 aactaatacg agagaatcta tttctaaatt agcattaaaa tcaaagaaaa tagacatttc
      241 acctaaagga actttattaa tgagttttaa attatctatt ggaaaagttg ccatattgga
      301 tattcctgcc actcataatg aagccattat atcgatattc ccctatgcta ataaagaaaa
      361 tattatcaga gattacttaa tgatattttt gccacttatc tctactttag gtgattcaaa
      421 agatgctatc aaagggaaaa cattaaatag taccagtatc tccgaattat taatccctat
      481 ttctaatcat gaagagatga aaagaatcat ttccaaagtt gatttacttt ttcaaaaagt
      541 ttctcaactt tttgagtaat aagttcctgt tcctcaaaag gagctaacgg aattaatagc
      601 tcgcttagtg tagttttagg aatattatat aaagcttgac ctgatagttt agttattgct
      661 ttcaattgtt tataaaataa cggagaggac aagttaaata atagaaattt tgaaataatc
      721 tctgaacttt cgaatggtgt taattggaaa ataaatccac cagccacaac accatcatag
      781 tctttatcga ttcttgcaaa ctttccaata tgttctaaag aggttgatac aggtgttatt
      841 agctgattat gttttaaata aacttgctca gaggagatga attgtgtatc aatgtagtaa
      901 tcgttatcca acagagaaaa ttctaaaggc ttaatattac caccacgtat aattctaaca
      961 cctttattat taatgcttaa atcgcccttc ttgtaagaaa gacctgtatt cattgaaaaa
     1021 atatctttta tttttataac aacccaattc ataggt
//
LOCUS       DAVLHC010000141         1056 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.142, whole genome shotgun sequence.
ACCESSION   DAVLHC010000141 DAVLHC010000000
VERSION     DAVLHC010000141.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1056)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1056)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1056
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.142"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            275..>1056
                     /locus_tag="VXE25_002211"
     CDS             275..>1056
                     /locus_tag="VXE25_002211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000169115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="U32 family peptidase"
                     /protein_id="HEV0772590.1"
                     /translation="MTKTLKRPEVLSPAGTLEKLKVAVQYGADAVFIGGQAYGLRSRA
                     GNFTFEQMEEGVQFAAKYGAKVYVAANMVMHEGNEAGAGEWFRKLRDIGIAAVIVSDP
                     ALIMIAATEAPGLEIHLSTQASATNYETLEFWKELGLTRVVLAREVSMEELAEIRKRT
                     DVEIEAFVHGAMCISYSGRCTLSNHMSMRDANRGGCSQSCRWKYDLYDMPFGKERKSL
                     QGEIPEEFSMSAVDMSMIDHIPDMIENGVDSLKIEGRMKSIH"
BASE COUNT          304 a          184 c          248 g          320 t
ORIGIN      
        1 tttccattat aggagcaaca gagtgggagt agtcatctaa ggactaattt atgtattttt
       61 acgagtcagt atctttggat actggttttt acttttctag actttttgac tacttgttaa
      121 aactgggata attttcgact gtttaacagt tattatgcaa agtctaaaag attagaattg
      181 tcaaaacaat ccgtctaggc ttgattttat cctttattta ctataaaatg agaaggaaaa
      241 atgtcaaact tttatattgc aaataggaga aatcatgaca aaaacattaa aacgtcctga
      301 ggttttatca cctgcaggaa ctttagagaa gctaaaggta gctgttcagt atggagcaga
      361 tgctgtcttt atcggtggtc aggcctatgg tcttcgtagc cgtgcgggaa actttacttt
      421 cgaacagatg gaagaaggcg tgcagtttgc ggccaagtat ggtgccaagg tctatgtagc
      481 ggctaatatg gttatgcacg aaggaaatga agctggtgct ggtgagtggt tccgtaaact
      541 gcgtgatatc gggattgcag cagttatcgt atctgaccca gccttgatta tgattgcagc
      601 gactgaagca ccaggtcttg aaatccacct ttctacccaa gccagtgcca ctaactatga
      661 aacccttgag ttctggaaag agctaggctt gactcgtgtc gttttagcgc gtgaggtttc
      721 aatggaagaa ttagctgaaa tccgcaaacg tacagatgtt gaaattgaag cctttgtcca
      781 tggagctatg tgtatttcat actctggacg ttgtactctt tcaaaccaca tgagtatgcg
      841 tgatgccaac cgtggtggat gttctcagtc atgccgttgg aaatacgacc tttacgatat
      901 gccatttggg aaagaacgta agagtttgca gggtgagatt ccagaagaat tttcaatgtc
      961 agccgttgac atgtctatga ttgaccacat tccagatatg attgaaaatg gtgtggacag
     1021 tctaaaaatc gaaggacgta tgaagtctat tcacta
//
LOCUS       DAVLHC010000142         1032 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.143, whole genome shotgun sequence.
ACCESSION   DAVLHC010000142 DAVLHC010000000
VERSION     DAVLHC010000142.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1032)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1032)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1032
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.143"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..574
                     /locus_tag="VXE25_002212"
     CDS             <1..574
                     /locus_tag="VXE25_002212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000151458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEV0772591.1"
                     /translation="KIPSRLYKIDTGKVLFDGVNINQIDKKILSQNLGVVPQDSFLLN
                     RSILDNITLKHEVTSQKIEEVCKAVQIYDEIMAMPMKFNTIISEMGSNISGGQRQRIA
                     LARALINNPSIVILDEATSALDTINEERITKYIQSQGCTQIIVAHRLSTIKDADVIFV
                     MKGGKIVESGNHKYLMDLGGEYYSLYTKRK"
     gene            587..757
                     /locus_tag="VXE25_002213"
     CDS             587..757
                     /locus_tag="VXE25_002213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000711941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772592.1"
                     /translation="MKKENEYVILTTASLGVMIGIVFAIFLDFPVEYGISLGLLNGIV
                     LGSLIVYKNNKN"
BASE COUNT          375 a          127 c          198 g          332 t
ORIGIN      
        1 aaaaatacca tcaagattat ataagattga tacaggaaaa gttttatttg atggtgtaaa
       61 tattaatcaa atagataaaa aaatattaag tcaaaattta ggagtagttc cacaggattc
      121 atttttattg aaccgaagta ttcttgataa tataacttta aagcacgaag ttacttcaca
      181 aaagatagag gaagtttgta aagcagttca aatctatgat gaaatcatgg ctatgccgat
      241 gaaatttaat actatcatct cagagatggg gtcaaatatt tcaggtgggc aaaggcaacg
      301 gatagcactg gcacgtgcat taataaataa tcctagtatt gtaattttag atgaagcaac
      361 tagtgcatta gacactatta atgaggaaag aataacaaag tatatacaaa gtcagggctg
      421 tactcaaata attgtagctc atagattgtc aacgattaag gatgcggatg ttatttttgt
      481 aatgaaaggt ggtaagattg ttgagtcagg aaatcataag tacttaatgg atcttggtgg
      541 agagtactac agcttatata caaaaaggaa atgaggtgta aagaaaatga agaaagaaaa
      601 tgaatatgta attttaacaa cagcctcact aggggtgatg attggaatag tgtttgcaat
      661 ttttttagat tttccagttg aatatggtat ttctttaggc ttgttgaatg gaatagtatt
      721 gggttcgctg attgtttaca aaaacaataa gaattaagca taattttttg ctgtaaacta
      781 aggagtagag atggctatag ttgaaattat aaatctaaca aaaagcttta aagatattga
      841 agttattcat aacacttaaa taatagagca actacagtag tagcttaaaa acatgattaa
      901 atcgctattc ttaggagtag cggtttttct ttttgtttaa tactctttga aaatctcttc
      961 aaaccacgtc agctttgctt taccgtactc aagtacagcc tgcggctcgc ttcctagttt
     1021 gctctttgat tt
//
LOCUS       DAVLHC010000143          944 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.144, whole genome shotgun sequence.
ACCESSION   DAVLHC010000143 DAVLHC010000000
VERSION     DAVLHC010000143.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 944)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 944)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..944
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.144"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..>944
                     /locus_tag="VXE25_002214"
     CDS             <1..>944
                     /locus_tag="VXE25_002214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436265.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3-like element IS1167A family transposase"
                     /protein_id="HEV0772593.1"
                     /translation="CGSLMKKYDFQKPSKIPYLETTGMPSRILLRKRRFKCYHCSKMM
                     VAETPLVKKNHQIPRIINQKIAQKLIEKISMTDIAHQLAISTSTVIRKLNDFHFEHDF
                     SRLPKIMSWDEYAFTKGKMSFIAQDFDNLNIITVLEGRTQAVIRNHFLRYDRAVRCQV
                     KIITMDMFSPYYDLAKQLFPCAKIVLDRFHIIQHLSRAMSRFRVQIMNQFERKSHEYK
                     AIKRYWKLIQQDSRKLSDKRFYRPTFRMHLTNKEILDKILSYSEDLKHHYQIYQLLLF
                     HFQNKDPEKFFGLIEDNLKQVHPIFQTVFKTFLKNKEK"
BASE COUNT          300 a          197 c          154 g          293 t
ORIGIN      
        1 tgtggaagtc taatgaagaa atatgacttt caaaaaccgt ctaagatccc ttacctcgaa
       61 acaactggta tgccttctag aattctcctt agaaaacgcc gtttcaagtg ctatcactgt
      121 tcaaaaatga tggttgctga gactcccctg gtaaagaaaa atcaccaaat ccctcgtatc
      181 atcaaccaaa aaattgctca aaagttaatt gaaaaaattt ctatgactga tattgcccat
      241 cagctggcca tttcaacttc aactgtcatt cgcaagctca atgactttca ctttgagcat
      301 gatttttctc ggcttccaaa gattatgtct tgggatgagt atgccttcac taagggaaag
      361 atgagtttca ttgcgcaaga ttttgataat cttaatatta tcactgttct tgaaggcaga
      421 acacaagctg tcatccgaaa tcactttctt cgctacgata gagccgttcg ttgtcaagtg
      481 aaaatcatta cgatggatat gtttagtcct tactatgact tggctaaaca gctttttccg
      541 tgtgctaaaa tcgttctaga tcgtttccat attatccaac atctcagccg tgccatgagt
      601 cgttttcgtg ttcaaattat gaatcagttt gaacgaaaat ctcatgaata caaggctatc
      661 aagcgttact ggaaactcat ccaacaggat agtcgtaaat tgagcgataa acgtttttat
      721 cgccctactt ttcgcatgca cttaacaaat aaagaaattc ttgacaagat tttaagctat
      781 tcagaagact tgaaacacca ctatcagatc tatcaactct tactttttca ctttcagaac
      841 aaagaccctg agaaattttt cggactcatt gaggacaatc tgaagcaggt tcatcctatt
      901 tttcagactg tctttaaaac ctttctaaag aacaaagaga aaat
//
LOCUS       DAVLHC010000144          927 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.145, whole genome shotgun sequence.
ACCESSION   DAVLHC010000144 DAVLHC010000000
VERSION     DAVLHC010000144.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 927)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 927)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..927
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.145"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            1..878
                     /locus_tag="VXE25_002215"
                     /pseudo
     CDS             1..878
                     /locus_tag="VXE25_002215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="frameshifted; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=3
                     /transl_table=11
                     /product="IS3 family transposase"
BASE COUNT          348 a          147 c          184 g          248 t
ORIGIN      
        1 aaatgggacg taagccaaaa aagagacctg aagagaggac agaattagaa cgtcttcaag
       61 cagaaaatga gtacctgaga gcggagaatg ccatcctaaa aaagttaaga gaactccgat
      121 tgaaggagga aaaagagaaa gaagaaagac agaaattgtt caagaattaa tgactgagtt
      181 ttcgttagat cttcttctaa aagccattaa actagctcgt tggacctact actatcactt
      241 gaaacagcta gacaaaacag ataaggacca agagcttaaa gctgaaattc aatccatttt
      301 tatcgaacac aagggaaatt atggttatcg tcgggttcat ttagaactaa gaaatcgtgg
      361 ttatctggta aatcataaaa gagttcaagg cttgatgaaa gtactcaatt tacaagctaa
      421 aatgcgacag aaacgaaaat attcttctca taaaggagac gttggtaaga aggcagagaa
      481 tctcattcaa ggccaatttg aaggctctaa aacaatggaa aagtgctaca cagatgtgac
      541 tgaatttgcc attccagcaa gtactcaaaa gctttactta tcaccagttt tagatggctt
      601 taacagcgaa attattgctt ttaatctttc ttgttcgtct aatttagaac aagtacaaac
      661 aatgttggaa caggcattca cagagaagca ctatggtgga gtccttcttt gggattctga
      721 aatcggaaat gttttatggc tatgagaaaa catttaaatc acttaatcaa ttggaacaag
      781 ctattataga ctatattgat tattacaaca acaagagaat taaggtaaaa ctaaaaggac
      841 ttagccctgt gcaatacaga actaaatcct tcggataaat taattgtcta actgtttggg
      901 gtgcagtaca gaactggcgt tttattt
//
LOCUS       DAVLHC010000145          923 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.146, whole genome shotgun sequence.
ACCESSION   DAVLHC010000145 DAVLHC010000000
VERSION     DAVLHC010000145.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 923)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 923)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..923
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.146"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            7..801
                     /locus_tag="VXE25_002216"
     CDS             7..801
                     /locus_tag="VXE25_002216"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000677523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEV0772594.1"
                     /translation="MKGLWSNNLTCGYDEKIILENINIKIPEEKISVIIGSNGCGKST
                     LIKTLSRLIKPLEGEVLLDNKSINSYKEKDLAKHIAILPQSPIIPESITVADLVSRGR
                     FPYRKPFKSLGKDDLEIINRSMVKANVEDLANNLVEELSGGQRQRVWIALALAQDTSI
                     LLLDEPTTYLDISYQIELLDLLTDLNQKYKTTICMILHDINLTARYADYLFAIKEGKL
                     VAEGKPEDILNDKLVKDIFNLEAKIIRDPISNSPLMIPIGKHHINS"
BASE COUNT          354 a          153 c          150 g          266 t
ORIGIN      
        1 tatataatga aaggtctgtg gtcaaataat cttacctgcg gttatgatga aaaaataatc
       61 ttggaaaata taaatataaa aatacctgaa gaaaaaatat cagttattat tgggtcaaat
      121 ggttgtggga aatcaacact cattaaaacc ttgtctcgac ttataaagcc attagaggga
      181 gaagtattgc ttgataataa atcaattaat tcttataaag aaaaagattt agcaaaacac
      241 atagctatat tacctcaatc tccaataatc cctgaatcaa taacagtagc tgatcttgta
      301 agccgtggtc gtttccccta cagaaagcct tttaagagtc ttggaaaaga tgaccttgaa
      361 ataataaaca gatcaatggt taaggccaat gttgaagatc tagcaaataa cctagttgaa
      421 gaactttctg ggggtcaaag gcaaagagta tggatagctc tagccctagc ccaagataca
      481 agtatcctac ttttagatga gccaactact tacttggata tctcatatca aatagaacta
      541 ttagacctct tgactgatct aaaccaaaaa tataagacaa ccatttgcat gattttgcac
      601 gatataaatc taacagcaag atacgctgat tacctatttg caattaaaga aggtaaactt
      661 gttgcagagg gaaagcctga agatatacta aatgataaac tagttaaaga tatctttaat
      721 cttgaagcaa aaattatacg tgaccctatt tccaattcgc ctctaatgat tcctattggc
      781 aagcaccata ttaactctta ataattgaat attggaattc atttaaaagt cgcaaatttt
      841 gaactgaccc tcaaaagtta ggccaaaaaa ctaactaaag gaggtcagtt ttttaatggc
      901 aaatacagca cagaatttaa gat
//
LOCUS       DAVLHC010000146          906 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.147, whole genome shotgun sequence.
ACCESSION   DAVLHC010000146 DAVLHC010000000
VERSION     DAVLHC010000146.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 906)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 906)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..906
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.147"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(85..834)
                     /locus_tag="VXE25_002217"
     CDS             complement(85..834)
                     /locus_tag="VXE25_002217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000069862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PIG-L family deacetylase"
                     /protein_id="HEV0772595.1"
                     /translation="MSNNTKYIFLSPHLDDAIFSCSDYISKLTSEGEIVLVITIFSGY
                     PLSQQLQPSAKQFHKLCNLGKYPIEERKKEDRLACERLQCDFRHLSYYECLYRKDRNG
                     NFLYRHIYSELKNEDTLKNDIIKELLMHLDDKCVVYCPLSLGDHVDHVFVNSIGRALE
                     FMRYKVIYYEDFPYVSDSSMVSYMGKTKELKMYQEELDEKHYIDRISSILCYKSQILI
                     IWKSVEKLLNNIKELYLRNGAAYSIRFWIKK"
BASE COUNT          313 a          178 c          104 g          311 t
ORIGIN      
        1 tttatattta gatgcaaata gtaacgcgta ggccagccca acatgcccca aaccaattac
       61 tgctatattc ataaaactac ttccttattt cttaatccaa aatctaatag aataagctgc
      121 cccattcctt aaatacaact ctttaatatt gtttaaaagt ttttcaactg atttccagat
      181 tatcaaaatc tgagatttat agcacaatat tgatgatatt ctatcaatat aatgtttttc
      241 atcaagttcc tcttgataca tttttaattc tttagttttt cccatataac taaccatact
      301 actatcactt acatatggga agtcctcata atatattact ttataacgca taaattcaag
      361 cgcccttcca atactattca caaaaacatg atcaacatgg tcaccaagtg aaagcggaca
      421 atatacgaca catttatcgt ctaaatgcat taacagctct tttatgatat cattctttaa
      481 tgtgtcctca ttttttaatt cactatagat atgacggtat agaaaattgc catttctatc
      541 tttcctatag agacattcat agtacgataa gtgtctaaaa tcacattgta gacgttcaca
      601 agctaacctg tcttctttct tcctttcttc aatcggatat ttcccaaggt tacacaactt
      661 atgaaattgc ttagcagagg gctgtagctg ttggctcaaa gggtaaccag aaaatatagt
      721 aataacaagt acaatttctc cttctgaagt taattttgaa atataatcac tacaggaaaa
      781 aattgcgtca tctaaatgtg gagataaaaa gatatactta gtattgttac tcataaccat
      841 tccctctaca atttatctaa aaactcacta agtgtctgat taaattccac atcatcaaaa
      901 aaattc
//
LOCUS       DAVLHC010000147          881 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.148, whole genome shotgun sequence.
ACCESSION   DAVLHC010000147 DAVLHC010000000
VERSION     DAVLHC010000147.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 881)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 881)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..881
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.148"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(8..81)
                     /locus_tag="VXE25_002218"
     tRNA            complement(8..81)
                     /locus_tag="VXE25_002218"
                     /product="tRNA-Ile"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(45..47),aa:Ile,seq:cat)
     gene            complement(95..168)
                     /locus_tag="VXE25_002219"
     tRNA            complement(95..168)
                     /locus_tag="VXE25_002219"
                     /product="tRNA-Met"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(132..134),aa:Met,seq:cat)
     gene            complement(174..247)
                     /locus_tag="VXE25_002220"
     tRNA            complement(174..247)
                     /locus_tag="VXE25_002220"
                     /product="tRNA-Pro"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(211..213),aa:Pro,seq:tgg)
     gene            complement(263..336)
                     /locus_tag="VXE25_002221"
     tRNA            complement(263..336)
                     /locus_tag="VXE25_002221"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(300..302),aa:Arg,seq:acg)
     gene            complement(346..431)
                     /locus_tag="VXE25_002222"
     tRNA            complement(346..431)
                     /locus_tag="VXE25_002222"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(395..397),aa:Leu,seq:taa)
     gene            complement(439..510)
                     /locus_tag="VXE25_002223"
     tRNA            complement(439..510)
                     /locus_tag="VXE25_002223"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(476..478),aa:Gly,seq:gcc)
     gene            complement(533..605)
                     /locus_tag="VXE25_002224"
     tRNA            complement(533..605)
                     /locus_tag="VXE25_002224"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(570..572),aa:Thr,seq:tgt)
     gene            complement(624..705)
                     /locus_tag="VXE25_002225"
     tRNA            complement(624..705)
                     /locus_tag="VXE25_002225"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(669..671),aa:Leu,seq:tag)
     gene            complement(711..783)
                     /locus_tag="VXE25_002226"
     tRNA            complement(711..783)
                     /locus_tag="VXE25_002226"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(748..750),aa:Lys,seq:ttt)
     gene            complement(808..880)
                     /locus_tag="VXE25_002227"
     tRNA            complement(808..880)
                     /locus_tag="VXE25_002227"
                     /product="tRNA-Asp"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(845..847),aa:Asp,seq:gtc)
BASE COUNT          232 a          257 c          199 g          193 t
ORIGIN      
        1 attcaaatgg accttgtagg acttgaacct acgaccactc ggttatgagc cgagagctct
       61 aaccagctga gctaaaggtc cgacaagatc attatagcgg cgaaggggat cgaacccccg
      121 acctcccggg tatgaaccgg acgctctagc cagctgagct acaccgccat gaatcgggaa
      181 gacaggattc gaacctgcga caccttggtc ccaaaccaag tactctacca agctgagcta
      241 cttcccgagt taaatagaaa aatgcaccct agaggagtcg aacctctaac cgcctgattc
      301 gtagtcaggt actctatcca gttgagctaa gggtgctcca tattatgccg aggaccggaa
      361 tcgaaccggt acgatcgtta ccaatcgcag gattttaagt cctgtgcgtc tgccagttcc
      421 gccaccccgg cctctctaag cgaacgacgg gattcgaacc cgcgaccccc accttggcaa
      481 ggtggtgttc taccactgaa ctacgttcgc actgttttct tctatctaaa aatgccggct
      541 acatgacttg aacacgcgac cctctgatta caaatcagat gctctaccaa ctgagctaag
      601 ccggctcatt tgttatatct taatgcgggt taagggactt gaacccccac gccgttaagc
      661 gccagatcct aaatctggtg cgtctgccaa ttccgccaaa cccgcatata tgacccgtac
      721 tgggctcgaa ccagtgaccc attgattaaa agtcaattgc tctaccaact gagctaacga
      781 gtctaaaata acttgcgtta ccttaaacgg tcccgacggg aatcgaaccc gcgatcttcg
      841 ccgtgacagg gcgacgtgat aaccgctaca ctacgggacc t
//
LOCUS       DAVLHC010000148          851 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.149, whole genome shotgun sequence.
ACCESSION   DAVLHC010000148 DAVLHC010000000
VERSION     DAVLHC010000148.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 851)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 851)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..851
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.149"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(<1..849)
                     /locus_tag="VXE25_002228"
     CDS             complement(<1..849)
                     /locus_tag="VXE25_002228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000598723.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HEV0772596.1"
                     /translation="MGDESYSFSTLIKVLNSETVPGASFSIMEIRLPKLLAGIIAGWS
                     FGLAGFIFQTMLRNPLASPDIIGVTSSSSIAAVFCILVLKTNSLTTGIISITCGLTSS
                     LILFLLAKKDGFSAARLIILGIGFQAVTRAGTSFLLLKVARYELQEVMRWLSGSLSFT
                     KLDDIPLVLIVSIIATILVLFFNKRLEIIELGEEIAIGLGANPELSRLVLIFCAVSLT
                     AFSTSITGPIACISFLAGPIALNIGKKRSPILAGLVGILLVLLSDIFSQNILPARYPV
                     GVVTGLL"
BASE COUNT          319 a          150 c          124 g          258 t
ORIGIN      
        1 taacaagcca gttacaacac ctactggata tctagctggt aaaatatttt gagagaatat
       61 gtctgataac aaaactagta aaattccaac caatccagct aatattgggc ttcttttctt
      121 gccaatattt aaggctatgg gaccagctaa aaaagatata caagctattg gtcctgtaat
      181 tgaagtagaa aaagcagtta aagatacagc gcaaaaaatt aaaacaagcc ttgaaagctc
      241 gggatttgct ccaagtccga ttgctatttc ttcaccaagt tcaataattt ctagtctttt
      301 attaaaaaat aaaactaata tagtagcaat aatacttact attagaacaa gaggtatgtc
      361 atctaacttt gtaaaagata aagagccact gagccatctc ataacttctt gtaattcata
      421 tcttgctact ttcaacaata aaaatgaggt gcctgctctt gtgacagctt gaaaaccaat
      481 acctaatatt atcagtcttg ctgctgaaaa accatctttt ttagctagta aaaataatat
      541 taaagatgat gttagtccac aagttattga aataattcca gtagttaaac tatttgtttt
      601 taataccaat atgcaaaaga ccgctgcaat agatgaagaa cttgtgacac cgattatatc
      661 aggacttgca agaggatttc ttaacatagt ttgaaagata aatcctgcca atccaaaaga
      721 ccagccagct ataattcctg ctaataattt tggtaatcta atttccataa tcgaaaaact
      781 agctccagga acagtttcac tatttaagac tttaatcaaa gttgaaaaag aataactttc
      841 atctccgata a
//
LOCUS       DAVLHC010000149          820 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.151, whole genome shotgun sequence.
ACCESSION   DAVLHC010000149 DAVLHC010000000
VERSION     DAVLHC010000149.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 820)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 820)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..820
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.151"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(<1..810)
                     /locus_tag="VXE25_002229"
     CDS             complement(<1..810)
                     /locus_tag="VXE25_002229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001832841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HEV0772597.1"
                     /translation="MFAILAGSSLAISGVLMQSVTRNPIADPGILGINTGASLSVVIG
                     LSFLGISSSISHISFAIIGGLVSAIFVYAIAVSGKAGLTPIKLALSGTCVSMALSSFV
                     SFLILPNNNVLDKFRFWQIGSLGAATLSSISTLLPFIILGHLIAIFISSDLNALAMGD
                     EMAVGLGVNVNRIRSLAIIASVLLCSSITAIGGPIGFVGLIVPHFCGLFISKDIRTMT
                     ISSSFIGAELLLICDIIGRMLGKPGEIEVGIITAIIGGPVLIYVTMKNRGVN"
BASE COUNT          293 a          164 c          126 g          237 t
ORIGIN      
        1 attaacccct ctatttttca tagttacata aataagtact ggacccccga ttattgcagt
       61 aattatccct acttcaattt cacctggttt acctaacata cggccgatta tatcacatat
      121 aagcaagagc tctgcaccta taaaagatga agaaatggtc attgtgcgta tatctttgct
      181 tataaataag ccacaaaagt gaggaactat aagacctacg aagccaatag gtccaccaat
      241 tgcagtaata cttgaacata aaagcacact tgcaattatt gcaagtgatc ttatcctatt
      301 aacattaact ccaagaccaa cagccatttc atcacccata gctaaagcgt ttaaatctga
      361 tgaaataaat atagctatca agtgacctaa aattataaaa ggtagtagtg tagatataga
      421 agataatgta gctgctccaa ggctacctat ttgccaaaat ctaaatttgt ctaagacgtt
      481 attattcggt aaaattaaaa aacttacaaa actgcttaaa gccatactaa cacaagttcc
      541 tgataaggca agttttatag gggtaaggcc tgcttttccg cttacagcaa tcgcgtatac
      601 aaaaattgca cttactaagc caccaatgat tgcaaaactt atatggctta tgcttgatga
      661 aattcctaaa aaagaaagac caattactac actaagactt gctcctgtgt ttataccgag
      721 tatacctgga tcagctattg ggtttctagt aactgattgc atcaatacac cgcttatggc
      781 aagactagaa cctgctaaaa ttgcaaaaat agttctaggt
//
LOCUS       DAVLHC010000150          817 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.152, whole genome shotgun sequence.
ACCESSION   DAVLHC010000150 DAVLHC010000000
VERSION     DAVLHC010000150.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 817)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 817)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..817
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.152"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(<1..>817)
                     /locus_tag="VXE25_002230"
     CDS             complement(<1..>817)
                     /locus_tag="VXE25_002230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000702186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="polysaccharide polymerase"
                     /protein_id="HEV0772598.1"
                     /translation="IVLILLPVYIKDRQISKIDAPSFYIVLWVMMYSISIIWNFLISG
                     LPIQVLFSDLSKAFNWILAVFFYNYYLKNPINVDKIKKYMFYNFAILVIIVALFYVQR
                     GANVVLFGRSLLGWDGFVSATSYGVRYAGFLEYSTLNGQLILFLLPLIRLFKLSFFTQ
                     VTILAFLLQVLVLSKSRIAIIALIIYIVFVVMVQITSINKRMIVAFYPTIPLILLYNW
                     EKIKHIFFQMFNSRTGSNVTRFIVYEESLKAINGLGILLGAGIRTQSTVGILLG"
BASE COUNT          326 a          140 c           95 g          256 t
ORIGIN      
        1 cctaataata tacctactgt agattgtgtt ctgattcctg ctccaagtaa aattcccagc
       61 ccattaatag ctttaagaga ttcttcgtac actataaaac gtgtcacatt actacctgtt
      121 cttgaattaa acatttgaaa aaagatatgt ttaatttttt cccaattata aagcaatata
      181 agaggtatag ttggataaaa cgctacaatc atccgcttat taattgaagt aatctgaacc
      241 attactacaa atactatgta tataatcaga gcaataatag ctattctaga tttactcaat
      301 actaaaacct gtagcaaaaa agcaagaata gttacttgtg taaaaaaact aagtttaaat
      361 aacctaatta acggtaacaa aaaaagaatc aactgcccat ttaatgttga atattctaaa
      421 aatcctgcat atcttactcc gtaactggta gctgatacga atccgtccca acctaataag
      481 cttcttccaa acaatactac attagcgcct ctttgaacat agaataaagc aacaataata
      541 actaatatag cgaaattata aaacatatat ttctttatct tgtcaacgtt aatgggattt
      601 ttcaaataat aattataaaa aaatactgct aatatccaat tgaatgcctt actcaaatct
      661 gaaaacaaca cttgaatagg taagccacta attaaaaaat tccaaattat tgatatagaa
      721 tacatcatga cccatagaac tatataaaaa gacggtgcat ctattttgga aatttgtcta
      781 tcttttatat agaccggtaa tagaattaag acaatta
//
LOCUS       DAVLHC010000151          809 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.153, whole genome shotgun sequence.
ACCESSION   DAVLHC010000151 DAVLHC010000000
VERSION     DAVLHC010000151.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 809)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 809)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..809
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.153"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            152..809
                     /locus_tag="VXE25_002231"
                     /pseudo
     CDS             152..809
                     /locus_tag="VXE25_002231"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611577.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
BASE COUNT          261 a          137 c          169 g          242 t
ORIGIN      
        1 tatatttcgc ctgatgggca aatcttataa agagattata gaacttttat agtggtttga
       61 aataagatgt gaacaactct atcaggaaag tcaaattaat ttatagaaat attttagcag
      121 ccaaggtgta ctgtcataga ttcaatacac tatagactgt aatcaaacaa cgatttggcg
      181 aaatgtaaaa aaatatgagg agttcggact cgactctctc cttcaagaaa cacgtggtgg
      241 tcgtaaccat catatatgac agttgaggaa gaaaaagcct ttcttgcccg ccatttgaag
      301 gctgcagagg caggagaatt tgttacaatt gatgccttat ttcaggctta taaaaaggag
      361 ttaggtcgtt cctacacacg tgatgccttc tatcaactgt tgaagcgcca tgattggcga
      421 aatattatgc cacgtccaga acatcctaag aaagcagacg ctcaaaccat tgtcgtgtct
      481 aaaaataaaa tctcaattaa agaagacaag aaagcgcttt aaaaccagta gacgttttcg
      541 taaggttcgc ttgatgtacc aagatgaagc tggtttcggt agaatcagta aactgggatc
      601 ttgttggtct caaataggag taggtccaca tgttcatagt cactatatac gagaatttcg
      661 ctattgttat ggagctgttg atgcctatac aggcgaatca tttttcttaa gagctggtgg
      721 atgtaatact gagtggatga acgtcttttt agaagagctt tcacaagctt atccatatga
      781 ttatttttta ctcgttatgg acaatgcta
//
LOCUS       DAVLHC010000152          788 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.154, whole genome shotgun sequence.
ACCESSION   DAVLHC010000152 DAVLHC010000000
VERSION     DAVLHC010000152.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 788)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 788)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..788
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.154"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            129..452
                     /gene="tnpB"
                     /locus_tag="VXE25_002232"
                     /pseudo
     CDS             129..452
                     /gene="tnpB"
                     /locus_tag="VXE25_002232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846105.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family insertion sequence element accessory
                     protein TnpB"
     gene            complement(593..>788)
                     /locus_tag="VXE25_002233"
     CDS             complement(593..>788)
                     /locus_tag="VXE25_002233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611577.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="IS630 family transposase"
                     /protein_id="HEV0772599.1"
                     /translation="PYTPEMNPIEQVWKEIRKRGFKNKAFRTLEDVMNQLQDVIQGLE
                     KEVIKSIVNRRWTRMLFENR"
BASE COUNT          232 a          150 c          140 g          266 t
ORIGIN      
        1 gctaagtgca tttaggagac tatacttaaa attcatagta agcgcgttca taacaaggta
       61 tctatcctaa ttccccaact tccagtatac tagataaaaa ataattatcg gagtaaaggt
      121 attgtactat gataattcaa ctaagtgatt taggtcaagt tcaccttgtt tgtggcaaga
      181 cagatatgag gtagggaata gactcattag cctatgtagt taaaacccac tttgaattgg
      241 attctttctc cggtcaagtc tttctctttt gtggtgaacg taaagaccgc tttaaagccc
      301 tttactggga tggtcaagga ttttggctac tatataaacg ctttgagaac ggaaaactga
      361 cttggctaag tacagaaaag gatgtcaaag ctctcgcacc tgaacaagta gattggctta
      421 tgaagggctt ttctatcact ccccaaatat agtggattta aactagaata gtacacctct
      481 gcttctaaaa cattgttaga aatcgatttg actatcctgt tcttatttca ttttactata
      541 aattcatcag aaagtcgtga tttctattga aatgaggact ttctttttat actcatctgt
      601 tttcaaaaag cattctagtc catctccgat taacgatgga ctttatcacc tccttctcca
      661 gtccttgtat gacatcttgg agttgattca tgacatcttc caaagttcga aaggccttat
      721 tcttaaatcc acgtttacga atctctttcc acacttgttc aatggggttc atctctggtg
      781 tgtatgga
//
LOCUS       DAVLHC010000153          699 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.155, whole genome shotgun sequence.
ACCESSION   DAVLHC010000153 DAVLHC010000000
VERSION     DAVLHC010000153.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 699)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 699)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..699
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.155"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            103..285
                     /locus_tag="VXE25_002234"
     CDS             103..285
                     /locus_tag="VXE25_002234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001262531.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ApaLI family restriction endonuclease"
                     /protein_id="HEV0772600.1"
                     /translation="MANDNKSHYLIYRVLGISFEEGENIDLYQNKGRFLYKYAGSFLE
                     EAAVLCFNEKFGTENT"
     gene            295..660
                     /locus_tag="VXE25_002235"
     CDS             295..660
                     /locus_tag="VXE25_002235"
                     /inference="COORDINATES: protein motif:HMM:NF021048.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ApaLI family restriction endonuclease"
                     /protein_id="HEV0772601.1"
                     /translation="MPNSESTKPKTFEIDCLVGEKHAYEIKWWDATTDGDHITKEHTR
                     IKVIHNKGYIPIRLMFYYPNRTQAIKIQQTLETLYNGIGGKYYYGDSAWEHLRAVTGI
                     DLLSILTDIANKKTGVKSK"
BASE COUNT          299 a           84 c          122 g          194 t
ORIGIN      
        1 acaagaggat agaaatgacc gaattagaaa gaaaaaatcg aaaaattagc taagaaatat
       61 tctgataact taaacatcaa agttcaagag agagttcgtg aaatggcaaa tgataataag
      121 agccattatt tgatatacag agttttaggt atttcatttg aagaaggaga aaatatcgat
      181 ttgtatcaaa ataaaggtcg ttttttatac aaatatgctg gttcattttt agaagaagct
      241 gcagtactat gctttaacga aaaatttggt acagaaaata cttaaaaagt taacattcct
      301 aattctgaaa gtacaaaacc taagactttt gaaattgatt gtttagtcgg agaaaaacac
      361 gcatacgaaa taaaatggtg ggatgcaact acagatggag accatataac taaagaacac
      421 actagaataa aagttattca taacaaagga tatataccaa ttcggttaat gttctactat
      481 ccaaatagaa ctcaagctat aaaaattcag caaactttag aaacattgta taacggtatt
      541 ggagggaaat attattatgg agattctgcc tgggaacatt taagagcagt gaccggtatt
      601 gatttactta gtattctaac agatattgca aataaaaaaa caggggtaaa atcaaaatga
      661 cagtattaaa aggagataac ttagaaatat taaaaacta
//
LOCUS       DAVLHC010000154          694 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.156, whole genome shotgun sequence.
ACCESSION   DAVLHC010000154 DAVLHC010000000
VERSION     DAVLHC010000154.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 694)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 694)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..694
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.156"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..>694
                     /locus_tag="VXE25_002236"
     CDS             <1..>694
                     /locus_tag="VXE25_002236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001017606.1"
                     /note="catalyzes the formation of UDP-glucuronate from
                     UDP-glucose; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 6-dehydrogenase"
                     /protein_id="HEV0772602.1"
                     /translation="PTDYDEKIGSFNTYEIEQTVSKILRVKPNGKIILKSTVPFGFSN
                     KLKRLFDTKNIIFVPEFLREGCSIYDNLYPSRIVVGDETVEGRKIAELFLSISTHSTA
                     NIKNVMLVSPTEAEAIKLFSNTFLALRVAFFNELDSFAERRSLNAEVVIKGVCLDPRI
                     GNFYNNLSFGFGGYCLPKDTKQLKKEFIEINAPVIEAIDISNTNRKQFIVKQILERKP
                     KIVGIYKLGMKYN"
BASE COUNT          254 a           84 c          127 g          229 t
ORIGIN      
        1 ccgacagatt atgatgagaa aattggtagt tttaatacat atgaaatcga acaaacggta
       61 tcgaagattc tgagggtaaa acctaatgga aagattattt taaagtcaac agttccgttc
      121 ggcttttcaa acaaattaaa aaggctgttt gatacaaaaa atatcatttt tgtccctgaa
      181 tttttgagag aaggttgttc tatatatgat aatttatatc caagtcgcat agttgttgga
      241 gatgagacag ttgaaggaag aaaaattgca gagttgttcc tttcgattag tactcatagt
      301 actgccaata ttaaaaatgt tatgttagtt tctcctactg aagcagaagc aattaagctt
      361 ttttctaaca cattcttagc tctccgtgtt gcttttttta atgaactaga ttcttttgct
      421 gagaggagaa gtttaaatgc tgaagttgta ataaaaggtg tttgtttaga tccaagaatt
      481 ggaaattttt ataataatct ttcttttgga tttggaggat attgtcttcc caaagatact
      541 aaacaattaa aaaaagaatt tatagaaata aatgccccag tgatagaagc gattgatatt
      601 tcaaacacaa atagaaaaca gttcatagtt aaacaaatat tggaacgaaa gccaaagata
      661 gtaggaatat ataaattggg gatgaaatat aatt
//
LOCUS       DAVLHC010000155          668 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.157, whole genome shotgun sequence.
ACCESSION   DAVLHC010000155 DAVLHC010000000
VERSION     DAVLHC010000155.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 668)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 668)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..668
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.157"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            83..445
                     /locus_tag="VXE25_002237"
     CDS             83..445
                     /locus_tag="VXE25_002237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein-export chaperone SecB"
                     /protein_id="HEV0772603.1"
                     /translation="MLEVGLNFLISLFTFTFDILYPIVKVGHTDDYSHGAVKLSVSLV
                     DKDAMKKISVTVIGYFEINIDENITDILYVNGTAILYHYLRSIVSIVSAIDSSEAMLL
                     PTINVLELLDKSQPFEEE"
BASE COUNT          223 a           83 c          121 g          241 t
ORIGIN      
        1 atctacaacc tcaaaacagt gttttgagca acctgaggct agtttcctag tttgctcttt
       61 ggttttcatt gagtataaca gattgttaga agttggttta aatttcctaa tcagtttgtt
      121 cacatttacc ttcgatatat tatatcccat agttaaggtt ggtcatacag atgattatag
      181 tcatggagcc gtaaaactta gtgtttcttt agttgacaaa gatgccatga aaaaaatatc
      241 tgtaactgta ataggatatt ttgaaataaa tatagatgaa aatatcaccg atattctata
      301 cgtaaatggt actgctattc tttatcatta tttacgttct attgtttcaa tagtttcggc
      361 aattgatagc agtgaagcaa tgttgctacc taccattaat gttttagagt tactagataa
      421 atctcaacct tttgaagaag aataatttat tagctcacta aattgagggt aaggaaaagt
      481 aaaatcagta agaaaaatgt cttgcattat acagcaacct tttgggaatg agtagatgga
      541 ttgaataaaa ttttattaag agtggatgat ttatctgtag attattattg gacagttagt
      601 cttgaagtag tctaagaatt aggttataat cagtagaatc cttgctaata atgaggaggt
      661 tagtttat
//
LOCUS       DAVLHC010000156          627 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.158, whole genome shotgun sequence.
ACCESSION   DAVLHC010000156 DAVLHC010000000
VERSION     DAVLHC010000156.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 627)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 627)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..627
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.158"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..>627
                     /locus_tag="VXE25_002238"
     CDS             <1..>627
                     /locus_tag="VXE25_002238"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="IS1380-like element ISSpn5 family transposase"
                     /protein_id="HEV0772604.1"
                     /translation="FLQFHQLNQLIVDIDSTHFTTYGKQEGVAYNAHYRAHGYHPLYA
                     FEGKTGYCFNAQLRPGNRYCSEEADSFITPVLERFNQLLFRMDSGFATPKLYDLIEKT
                     GQYYLIKLKKNTVLSRLGDLSLPCPQDEDLTILPHSAYSETLYQAGSWSHKRRVCQFS
                     ERKEGNLFYDVISLVTNMTSGTSQDQFQLYRGRGQAENFIKEMKEGFF"
BASE COUNT          173 a          146 c          124 g          184 t
ORIGIN      
        1 tctttttaca gtttcaccag ctaaaccaac tcattgtaga tatcgattct acccatttca
       61 caacttatgg caagcaagaa ggtgttgctt ataacgccca ctatcgtgct catggctatc
      121 atcctcttta tgctttcgag gggaagacag gttattgttt caatgcccag cttcgtcctg
      181 gtaatcgtta ttgttctgaa gaggcagaca gctttatcac acctgtttta gaacggttta
      241 atcaacttct ctttcgaatg gatagtggct ttgcgacccc aaaattatac gatttaattg
      301 aaaaaacagg gcaatactac ctcataaaac tcaagaaaaa tactgttctg agccgtcttg
      361 gagacctttc cctcccttgc ccacaggatg aggacttaac catcttgccc cactccgcct
      421 actcagaaac tctctatcaa gcaggatctt ggtcgcacaa gcgtcgtgtc tgccagttct
      481 ctgaacgaaa agaaggaaac ttgttctacg atgttatttc tctcgttaca aatatgacga
      541 gtggaacaag ccaagaccag tttcagcttt atcgtggacg tggtcaagcc gagaatttca
      601 tcaaggagat gaaggaggga ttttttg
//
LOCUS       DAVLHC010000157          611 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.159, whole genome shotgun sequence.
ACCESSION   DAVLHC010000157 DAVLHC010000000
VERSION     DAVLHC010000157.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 611)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 611)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..611
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.159"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..605
                     /locus_tag="VXE25_002239"
     CDS             <1..605
                     /locus_tag="VXE25_002239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002837029.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEV0772605.1"
                     /translation="GGEYQIKNLSYKFTDDECLSLKDISFKLGKIYGIIGSNGRGKST
                     LLRCLIGLEKKSKEEIYFKGEKLSKKERLKNSSLVMQDVNHQLFTDEVFNELRLGVKN
                     FDEEKAKIILKDLGLDEFIERHPMSLSGGQKQRLAIASVMCKNSPFVFFDEPSSGMDY
                     SNMIKISELINKYKTMDKIIFIVSHDIEFLNEVADEIFEL"
BASE COUNT          238 a           70 c          118 g          185 t
ORIGIN      
        1 aaggtggaga gtatcagata aaaaatctta gctacaaatt tactgatgat gagtgtttaa
       61 gcttaaaaga tatttcgttc aagcttggga aaatttatgg cataatagga tccaacggac
      121 gaggaaaatc aacgctttta agatgtttaa taggtcttga gaaaaaatca aaagaagaaa
      181 tttattttaa gggagagaag ctatctaaaa aagaaagact caaaaactct tcacttgtta
      241 tgcaagatgt aaatcatcaa ttattcacag atgaagtatt caacgagctt agattaggag
      301 taaagaattt tgatgaagaa aaggcgaaaa tcatcttaaa agatttaggc ctggacgaat
      361 ttattgaaag gcatccgatg agtttatcag gagggcaaaa gcaaaggctt gcaatagcat
      421 ctgttatgtg caagaattct ccatttgtct tttttgacga accttcaagt ggtatggatt
      481 attccaatat gataaaaata tctgaactga ttaataagta taaaaccatg gataaaataa
      541 tttttattgt ttcccatgat atagaatttt taaatgaagt ggcagatgaa atttttgaat
      601 tgtaaaatag a
//
LOCUS       DAVLHC010000158          604 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.160, whole genome shotgun sequence.
ACCESSION   DAVLHC010000158 DAVLHC010000000
VERSION     DAVLHC010000158.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 604)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 604)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..604
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.160"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(<1..194)
                     /locus_tag="VXE25_002240"
     CDS             complement(<1..194)
                     /locus_tag="VXE25_002240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="autolysin"
                     /protein_id="HEV0772606.1"
                     /translation="MDIDRNRLRTGLPQVGVQPYRQVHAHSTGNRNSTVQNEADYHWR
                     KDPELGFFSHVVGNGRIMQVG"
     gene            complement(198..530)
                     /locus_tag="VXE25_002241"
     CDS             complement(198..530)
                     /locus_tag="VXE25_002241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001186229.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage holin"
                     /protein_id="HEV0772607.1"
                     /translation="MQQITEIITNGAISILVILAGIAVKAVKDYLVQKGGEKTIKIVE
                     ILAKNAVNAVEQVAAETGYKGDEKLAQARAKVRAELTKYNISMTDKDLDTFVESAVKQ
                     MNDAWKGR"
BASE COUNT          125 a          155 c          119 g          205 t
ORIGIN      
        1 cctacctgca tgatgcgacc gttcccaaca acgtgcgaga aaaaacctaa ttctgggtct
       61 ttccgccagt gataatccgc ttcattctgt acggttgagt tgcggttacc tgttgagtga
      121 gcatgtactt gtcgataagg ctgcacccca acctggggca agcctgtacg tagtctgttt
      181 ctatcgatat ccattcccta tcgtcctttc catgcgtcat tcatctgctt cactgctgac
      241 tctacgaagg tgtctaagtc tttgtcagtc atgctaatat tgtattttgt aagctcagca
      301 cggactttag cgcgagcctg tgccagtttt tcatctccct tgtagccagt ttcagcagct
      361 acctgctcca cggcatttac tgcatttttg gccaagattt caacaatctt gatggtcttt
      421 tctccacctt tttgaaccag gtagtccttg actgccttga ctgcgatacc agccaaaata
      481 acaaggatgc tgattgctcc attagtaatg atttcagtaa tttgttgcat ttgttattct
      541 cctttttcga tttcttccat gcggtcgttc atgcgaacca tttctttttg aatgtctccg
      601 accg
//
LOCUS       DAVLHC010000159          604 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.161, whole genome shotgun sequence.
ACCESSION   DAVLHC010000159 DAVLHC010000000
VERSION     DAVLHC010000159.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 604)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 604)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..604
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.161"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            75..407
                     /locus_tag="VXE25_002242"
     CDS             75..407
                     /locus_tag="VXE25_002242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001186229.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage holin"
                     /protein_id="HEV0772608.1"
                     /translation="MQQITEIITNGAISILVILAGVVVRVVKEYLVKKGGEKTIKIVE
                     ILAKNAVNAVEQVAAETGYKGDEKLAQARAKIRAELTKYNISMTDKDLDTFVESAVKQ
                     MNDAWKGR"
     gene            411..>604
                     /locus_tag="VXE25_002243"
     CDS             411..>604
                     /locus_tag="VXE25_002243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="autolysin"
                     /protein_id="HEV0772609.1"
                     /translation="MDIDRNRLRTGLPQVGVQPYRQVHAHSTGNRNSTAQNEADYHYR
                     KDPELGFFSHVVGNGRVMQVG"
BASE COUNT          209 a          117 c          154 g          124 t
ORIGIN      
        1 cggtcggaga cattcaaaaa gaaatggttc gcatgaacga ccgcatggaa gaaatcgaaa
       61 aaggagaata acaaatgcaa caaattactg aaatcattac taatggagca atcagcatcc
      121 tagtcatttt ggcaggggtg gtagttaggg tagtcaagga atacctcgtc aaaaaaggtg
      181 gagaaaagac tatcaagatt gttgaaatct tggccaagaa cgcagttaat gccgtggagc
      241 aggtagctgc tgaaactggc tacaagggag atgaaaaact ggcacaggcc cgcgctaaaa
      301 ttcgtgctga gctgaccaaa tataatatca gtatgactga caaagactta gacaccttcg
      361 tagagtcagc agtgaagcag atgaatgacg catggaaagg acgataggga atggatatcg
      421 atagaaacag actacgtaca ggcttgccac aggttggggt gcagccttat cgacaagtac
      481 atgctcactc aacaggcaac cgtaactcaa ccgctcaaaa tgaagctgat taccactata
      541 gaaaggaccc tgaactaggg ttcttttcac atgttgtcgg aaacggccgt gtcatgcaag
      601 tagg
//
LOCUS       DAVLHC010000160          567 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.162, whole genome shotgun sequence.
ACCESSION   DAVLHC010000160 DAVLHC010000000
VERSION     DAVLHC010000160.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 567)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 567)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..567
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.162"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            complement(<1..>567)
                     /locus_tag="VXE25_002244"
     CDS             complement(<1..>567)
                     /locus_tag="VXE25_002244"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HEV0772610.1"
                     /translation="LLLKAIKLARSTYYYHLKQLDKTDKDQELKAEIQSIFIEHKGNY
                     GYRRIYLELRNRGYLVNHKRVQGLMKVLNLQAKMRQKRKYSSHKGDVGKKAENLIQGQ
                     FEGSKTMEKCYTDVTEFAIPASTQKLYLSPVLDGFNSEIIAYNLSTSPNLEQVQTMLE
                     QAFKEKHYENTILHSDQGWQYQHDSYHR"
BASE COUNT          150 a           98 c          110 g          209 t
ORIGIN      
        1 aaccgatgat aagaatcgtg ttggtattgc cagccttggt cactatggag aatcgtattc
       61 tcatagtgct tctctttgaa tgcctgttcc aacattgttt gtacttgttc taagttgggt
      121 gaagttgaaa gattataggc gataatttca ctgttaaagc catctaaaac tggtgataag
      181 taaagctttt gagtactggc tggaatggca aattctgtca catctgtgta gcacttttcc
      241 attgttttag agccttcaaa ttggccttga atgagattct ctgctttctt accaacgtct
      301 cctttatgag aagaatattt tcgtttctgt cgcattttag cttgtaaatt gagtactttc
      361 atcaagcctt gaactctttt atgatttacc agataaccac gatttcttag ttctaaataa
      421 atccgacgat aaccataatt tcccttgtgt tcgataaaaa tggattgaat ttcagcttta
      481 agctcttggt ccttatctgt tttgtctagc tgtttcaagt gatagtagta ggtcgaacga
      541 gctagtttaa tggcttttag aagaaga
//
LOCUS       DAVLHC010000161          549 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.163, whole genome shotgun sequence.
ACCESSION   DAVLHC010000161 DAVLHC010000000
VERSION     DAVLHC010000161.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 549)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 549)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..549
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.163"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..262
                     /locus_tag="VXE25_002245"
     CDS             <1..262
                     /locus_tag="VXE25_002245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810280.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="RNA helicase"
                     /protein_id="HEV0772611.1"
                     /translation="FGDYYQKTFSTSRRGNKGKRIHSSFENWLKVISDSGYEIDLSSL
                     SKSYRCPKIVCDFIVDNLAIEILSQREEKLSSQITLIDSQKK"
BASE COUNT          204 a           68 c          100 g          177 t
ORIGIN      
        1 atttggagat tattatcaaa aaacctttag tacttcaagg cgaggtaata aaggaaaaag
       61 gatccattcg agttttgaga attggttaaa agttatttct gattcaggat atgaaattga
      121 tttatcgagt ttgtcaaaaa gttatcgttg tcccaaaata gtttgtgact ttattgttga
      181 taatttagct attgaaattt tatcacagcg agaagaaaag ctatcttccc aaattactct
      241 tatcgattca cagaaaaaat agaatcaata atgacagatg acaatattat gaaacttttt
      301 tatcaaaaat cttatgatta tgaatgcaag agtcagaatt ggggggatag taaaggctct
      361 gaatatgaca atgtttgtgt agtattaaat ccaacatcat acaaattatt cgcagctgat
      421 ctcttgaatg aactttcttc acaaaccaaa agtaaatttt acgttgcgtg tacacgtacg
      481 agggggaact tatattttgt aaagcaatcc gatatagaaa aatataggaa gatgatgtaa
      541 gggaaatat
//
LOCUS       DAVLHC010000162          452 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.164, whole genome shotgun sequence.
ACCESSION   DAVLHC010000162 DAVLHC010000000
VERSION     DAVLHC010000162.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 452)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.164"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..429
                     /locus_tag="VXE25_002246"
     CDS             <1..429
                     /locus_tag="VXE25_002246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772612.1"
                     /translation="DHVRKNKADQDSKPDEDKEHDEVSEPTHPESDEKENHAGLNPSA
                     DNLYKPSTDTEETEEEAEDTTDEAEIPQVENSVINAKIADAEALLEKVTDPSIRQNAM
                     ETLTGLKSSLLLGTKDNNTISAEVDSLLALLKKSQPAPIQ"
BASE COUNT          174 a           76 c           97 g          105 t
ORIGIN      
        1 gaccatgttc gtaaaaataa ggcagaccaa gacagtaaac ctgatgaaga taaggaacat
       61 gatgaagtaa gtgagccaac tcaccctgaa tctgatgaaa aagagaatca cgctggttta
      121 aatccttcag cagataatct ttataaacca agcactgata cggaagagac agaggaagaa
      181 gctgaagata ccacagatga ggctgaaatt cctcaagtag agaattctgt tattaacgct
      241 aagatagcag atgcggaggc cttgctagaa aaagtaacag atcctagtat tagacaaaat
      301 gctatggaga cattgactgg tctaaaaagt agtcttcttc tcggaacgaa agataataac
      361 actatttcag cagaagtaga tagtctcttg gctttgttaa aaaaaagtca accggctccg
      421 atacagtagt aaaatgaatg gagcatattt ta
//
LOCUS       DAVLHC010000163          371 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.denovo.165, whole genome shotgun sequence.
ACCESSION   DAVLHC010000163 DAVLHC010000000
VERSION     DAVLHC010000163.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 371)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 371)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.denovo.165"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            <1..>371
                     /locus_tag="VXE25_002247"
     CDS             <1..>371
                     /locus_tag="VXE25_002247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001821980.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772613.1"
                     /translation="GRNFWNVFNCFKHYLFRKNSETGVQSGPDYATLGMYKGSADWKY
                     ITFTYDYSEKTNFDQLKTSLRFNLEGATSGTAWVTGIKVEIGSVATDWSPAPEDADGL
                     ITEAKATFERTAQGLRTDLSA"
BASE COUNT          111 a           64 c           91 g          105 t
ORIGIN      
        1 aaggtcgaaa tttttggaat gtatttaatt gcttcaaaca ttatcttttt agaaaaaata
       61 gtgagaccgg agtacagagt ggtccagatt atgctacgct tggtatgtat aaaggttcgg
      121 cagattggaa atatattaca ttcacttatg actactctga aaaaacaaat tttgatcaat
      181 tgaagacatc attgcgattc aatcttgaag gtgctacaag cggtacagct tgggtaacag
      241 gaatcaaggt tgaaatcggt agtgtggcga cggactggag tcctgcgcct gaggacgctg
      301 atggtctcat cactgaagct aaggctacct ttgagcggac agctcagggc ttgcgaaccg
      361 atttatcagc t
//
LOCUS       DAVLHC010000164        15947 bp    DNA     linear   BCT 18-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain AUSMDU00037298
            SAMN33606899-rid17953033.guided.039, whole genome shotgun sequence.
ACCESSION   DAVLHC010000164 DAVLHC010000000
VERSION     DAVLHC010000164.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN33606899
            Sequence Read Archive: SRR23725965
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 15947)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15947)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAY-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 06-MAY-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001721842.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001721842.1
            Genome Coverage       :: 155x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 05/07/2023 01:57:01
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,267
            CDSs (total)                      :: 2,224
            Genes (coding)                    :: 2,085
            CDSs (with protein)               :: 2,085
            Genes (RNA)                       :: 43
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 37
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 57 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 49 of 139
            Pseudo Genes (multiple problems)  :: 26 of 139
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15947
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN33606899-rid17953033.guided.039"
                     /strain="AUSMDU00037298"
                     /serotype="15B/15C"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Australia: Victoria"
                     /collection_date="2018"
                     /collected_by="MDU-PHL"
                     /note="genotype: ST162"
     gene            244..813
                     /locus_tag="VXE25_002248"
     CDS             244..813
                     /locus_tag="VXE25_002248"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000443767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEV0772614.1"
                     /translation="MESIFVKLAQYPSIETERLLLRPVTLDDAEAMFDYASDKGNTRY
                     TFPTNQSLEETKNNIAQFYLANPLGRWGIELKSNGKFIGTIDLHKIDPVLKKVAIGYI
                     INQTYWNQGLTTETNRAVIELAFEKIGMNKLVALYDKANPASGKVMEKSGMRFSHAEP
                     YACMYQHEKGRIVTRVHYVLTKEDYFANK"
     gene            881..1531
                     /locus_tag="VXE25_002249"
     CDS             881..1531
                     /locus_tag="VXE25_002249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000387331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComEA family DNA-binding protein"
                     /protein_id="HEV0772615.1"
                     /translation="MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQ
                     AEVAAVSKDLVSEKEVNKEEKEEPLEQDLITVDVKGAVKSPGIYDLPVGSRVNDAVHK
                     AGGLTEQADSKSLNLAQKVSDEALVYVPTKGEESVSQQTGLGTASSISKEKKVNLNKA
                     SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD"
     gene            1515..3197
                     /locus_tag="VXE25_002250"
     CDS             1515..3197
                     /locus_tag="VXE25_002250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000942381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComEC/Rec2 family competence protein"
                     /protein_id="HEV0772616.1"
                     /translation="MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCL
                     FIQFPWKSAGKVLIICGIFGFWFVFQNWQQSQVSQNLVDSVERVRILPDTIKVNGDSL
                     SFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
                     LKTQGIYQTLNIKKIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLL
                     GYLNTDFEEMNELYSSLGIIHLFALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPF
                     SLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIVMPNFFLTAGGVLSC
                     AYAFILTMTSKEGEGLKAVASESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDL
                     TFLPLLSILFVLSFLYPVIQLNFIFEWLEGIIRLVSQVARRPLVFGQPNAWLLILLLI
                     SLALVYDLRKNIKGLTVLSLLITGLFFLTKYPLENEITMLDVGQGESIFLRDVTGKTI
                     LIDVGGKAESYKKIEKWQEKMTTSNAQRSLIPYLKSRGVAKIDQLILTNTEV"
     gene            3302..3958
                     /locus_tag="VXE25_002251"
     CDS             3302..3958
                     /locus_tag="VXE25_002251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CpXC domain-containing protein"
                     /protein_id="HEV0772617.1"
                     /translation="MMKRKIRMTTIFLTRTSCSNCGKQSTFERFDRVYAAKTPEIISA
                     ILDWDFFKFTCHNCNHKVLIDYPTVVVDEEQKTIIQYCADGNVDVLSMQICSLISEGV
                     NLSEYRIRVVSDIESFVEKVQIVSVGYDDRAIELMKYMNSPLEDGDIQFNYEHMVFTK
                     VGHENYQFMFINNQIAVASLDFSQEQYEYYLADVEDLETNTYYIDSRWAESFFRTSLA
                     "
     gene            4087..5199
                     /locus_tag="VXE25_002252"
     CDS             4087..5199
                     /locus_tag="VXE25_002252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HEV0772618.1"
                     /translation="MVRRNSKITRQQKKIRDAFVSERTVEIIPAKREFTDVKTKKLRV
                     AAYCRVSTFDESQSGSFELQKQTYTERINSNPDWIMAGIYADQGASGTSIKRREQFQQ
                     MLHDCRCGKIDLIIVKSVSRFARNQLDFISIYRELKALSPPVGIYIEDINLNTLDTNS
                     EFILGIMAIVAQGESEQKSASITWSVIERFKRGIPMIPTHNLLGYTKDQYGRVVIDET
                     EAKIVRLIYDSYIEGMTASEIASTLMTNHIPTVTGLERWTSLAVYNILRNEKYKGEII
                     MQKTYTVDCFSHKTRKNNGEKPKYRLKNGIPSIIPESRWDLVQELLKQPRRKSKSTSE
                     IFVPKLYIKKLKSGKLRDFVVLDPSWKSEDIHEVFK"
     gene            5214..5630
                     /locus_tag="VXE25_002253"
     CDS             5214..5630
                     /locus_tag="VXE25_002253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001211122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772619.1"
                     /translation="MRFKDFNLEVVNVERYSSDYSMTVNKNFVTFSKGIVQALEYPAH
                     VLVAFNKDTKVMGIQVCRAKTRGAFSFSKPVGEQKGIVQVGHKTLKETLLTIMSEWKS
                     DKRYRVEGIHIPEDKAFVFELKDFDELSDFRKNDNR"
     gene            5740..5951
                     /locus_tag="VXE25_002254"
                     /pseudo
     CDS             5740..5951
                     /locus_tag="VXE25_002254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018368983.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1643 domain-containing protein"
     gene            6444..7661
                     /gene="mef(A)"
                     /locus_tag="VXE25_002255"
     CDS             6444..7661
                     /gene="mef(A)"
                     /locus_tag="VXE25_002255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012102963.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="macrolide efflux MFS transporter Mef(A)"
                     /protein_id="HEV0772620.1"
                     /translation="MEKYNNWKLKFYTIWAGQAVSLITSAILQMAIIFYLTEKTGSAM
                     VLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSVLTIVAFYMELPV
                     WMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAAL
                     LYSVWELNAIIAIDVLGAVIASITVAIVRIPKLGDRVQSLDPNFIREMQEGMAVLRQN
                     KGLFALLLVGTLYMFVYMPINALFPLISMDYFNGTPVHISITEISFASGMLIGGLLLG
                     LFGNYQKRILLITASIFMMGISLTISGLLPQSGFFIFVVCCAIMGLSVPFYSGVQTAL
                     FQEKIKPEYLGRVFSLTGSIMSLAMPIGLILSALFADRIGVNHWFLLSGTLIICIAIV
                     CPMINEIRKLDLK"
     gene            7781..9244
                     /gene="msr(D)"
                     /locus_tag="VXE25_002256"
     CDS             7781..9244
                     /gene="msr(D)"
                     /locus_tag="VXE25_002256"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000420317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F type ribosomal protection protein Msr(D)"
                     /protein_id="HEV0772621.1"
                     /translation="MELILKAKDISVEFKGHDVLDINELEVYDYDRIGLVGANGAGKS
                     TLFKVLLGELIPPGCKMNHLGELAYIPQLDEVTLQEEKDFALVGKLGVEQLNIQTMSG
                     GEETRLKIAQALSAQVHGILADEPTSHLDREGIDFLIGQLKYFTGALLVISHDRYFLD
                     EIVDKIWELKDGKITEYWGNYSDYLRQKEEERKRQAAEYEQFIAERARLERAAEEKRK
                     QARKIEQKAKGSSKKKSTEGGGRLAHQKSIGSKEKKMHNAAKSLENRIAALGKVEAPE
                     GIRRIRFRQSKALELHNPYPIVGAEINKVFGDKALFENASFQIPLGAKVALTGGNGTG
                     KTTLIQMILNHEEGISISPKAKIGYFAQNGYKYNSNQNVMEFMQKDCDYNISEIRSVL
                     ASMGFKQNDIGKSLSVLSGGEIIKLLLAKMLMGRYNILIMDEPSNFLDIPSLEALEIL
                     MKEYTGTIVFITHDKRLLENVADVVYEIRDKKIKLKH"
     gene            complement(9362..9661)
                     /locus_tag="VXE25_002257"
     CDS             complement(9362..9661)
                     /locus_tag="VXE25_002257"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018374804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772622.1"
                     /translation="MNQLEFQRNHLQMDYYSESYQDFERDFYRYSNMNIPLTFLTDDI
                     LKTMATSRKNYFVLNKEKSRDNRDHFFIFEVRTLEENPLIYHYTYKKTTTYLAEK"
     gene            complement(9648..10016)
                     /locus_tag="VXE25_002258"
     CDS             complement(9648..10016)
                     /locus_tag="VXE25_002258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254363.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772623.1"
                     /translation="MIDRSYLPFQSAREYQDTKMQKWMGFFLSEHTSALTDDANKVTY
                     MSDLSLEKKLLLLSQVYAGQLNTRIHVVKKNNQVSYTGTIPSLTKDFILIKTTTGHIN
                     LKLKDIVSIELVEEVLYESA"
     gene            complement(10013..10438)
                     /locus_tag="VXE25_002259"
                     /pseudo
     CDS             complement(10013..10438)
                     /locus_tag="VXE25_002259"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003059255.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase"
     gene            10388..11227
                     /locus_tag="VXE25_002260"
     CDS             10388..11227
                     /locus_tag="VXE25_002260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014632453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEV0772624.1"
                     /translation="MNRNDSSFFMCRAKTVSPDLKMGVDRERKIYQALYPLNIKAHTL
                     EFPTHGIDQIVWILEAIIPSLFVVAIIFMLTQLFAERYPNHLDTAQLYPFSKVAFALS
                     SLGVGVGYVSVLFIGICGFSFLVGSLISGFGQLDYPYPIYSLVNQEVTIGKIQDVLFP
                     GLFLAFLAFIVIVEVVYLIAYFFKQKMPVLFLSLIGIVGLLFGIQTIQPLQRIAHLIP
                     FTYLRSVEILSGSLPKQIDNVNLNWGMGLVLLPCLIILLLVGILFIESWGSSRKKEVF
                     NRS"
     misc_feature    11388..11519
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00558"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="ribosomal protein L20 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00558"
     gene            11535..12065
                     /gene="infC"
                     /locus_tag="VXE25_002261"
     CDS             11535..12065
                     /gene="infC"
                     /locus_tag="VXE25_002261"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000848185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-3"
                     /protein_id="HEV0772625.1"
                     /translation="MKTIAKQDLFINDEIRVREVRLIGLEGEQLGIKPLSEAQALADN
                     ANVDLVLIQPQAKPPVAKIMDYGKFKFEYQKKQKEQRKKQSVVTVKEVRLSPTIDKGD
                     FDTKLRNARKFLEKGNKVKVSIRFKGRMITHKEIGAKVLAEFAEATQDIAIIEQRAKM
                     DGRQMFMQLAPATDKK"
     gene            12098..12298
                     /gene="rpmI"
                     /locus_tag="VXE25_002262"
     CDS             12098..12298
                     /gene="rpmI"
                     /locus_tag="VXE25_002262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001125942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L35"
                     /protein_id="HEV0772626.1"
                     /translation="MPKQKTHRASAKRFKRTGSGGLKRFRAYTSHRFHGKTKKQRRHL
                     RKASMVHSGDYKRIKAMLTRLK"
     gene            12350..12709
                     /gene="rplT"
                     /locus_tag="VXE25_002263"
     CDS             12350..12709
                     /gene="rplT"
                     /locus_tag="VXE25_002263"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019786714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L20"
                     /protein_id="HEV0772627.1"
                     /translation="MARVKGGVVSRKRRKRILKLAKGYYGAKHILFRTAKEQVMNSYY
                     YAYRDRRQKKRDFRKLWITRINAAARMNGLSYSQLMHGLKLAEIEVNRKMLADLAVND
                     AVAFTALADAAKAKLGK"
     gene            12767..13147
                     /locus_tag="VXE25_002264"
     CDS             12767..13147
                     /locus_tag="VXE25_002264"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HEV0772628.1"
                     /translation="MASKMLHTCLRVENLEKSIAFYQDAFGFKELRRRDFPDHAFTIV
                     YLGLEGDDYELELTYNYDHGPYVVGDGFAHIALSTPDLEALHQEHSAKGYEVTEPNGL
                     PGTTPNYYFVKDPDGYKVEVIREK"
     gene            13397..14197
                     /locus_tag="VXE25_002265"
     CDS             13397..14197
                     /locus_tag="VXE25_002265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate dehydrogenase electron transfer
                     subunit"
                     /protein_id="HEV0772629.1"
                     /translation="MNPTCKKRLGVIRLETMKVVAQEEIAPAIFELVLEGEMVEAMRA
                     GQFLHLRVPDDAHLLRRPISISSIDKANKQCHLIYRIEGAGTAIFSTLSQGDTLDVMG
                     PQGNGFDLSDLDEQNQVLLVGGGIGVPPLLEVAKELHERGVKVVTVLGFANKDAVILK
                     TELAQYGQVFVTTDDGSYGIKGNVSVVINDLDSQFDAVYSCGAPGMMKYINQTFDDHP
                     RAYLSLESRMACGMGACYACVLKVPESETVSQRVCEDGPVFRTGTVVL"
     gene            14160..15146
                     /locus_tag="VXE25_002266"
     CDS             14160..15146
                     /locus_tag="VXE25_002266"
                     /EC_number="1.3.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013193458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate dehydrogenase"
                     /protein_id="HEV0772630.1"
                     /translation="MVLFSAQEQLYYKEKIMTTNRLQVSLPGLDLKNPIIPASGCFGF
                     GQEYAKYYDLNLLGSIMIKATTLEPRFGNPTPRVAETPAGMLNAIGLQNPGLEVVLAE
                     KLPWLEREYPNLPIIANVAGFSKQEYAAVSHGISKATNVKAIELNISCPNVDHCNHGL
                     LIGQDPDLAYDVVKAAVEASEVPVYVKLTPSVTDIVTVAKAAEDAGASGLTMINTLVG
                     MRFDLKTRKPILANGTGGMSGPAVFPVALKLIRQVAQTTDLPIIGMGGVDSAEAALEM
                     YLAGASAIGVGTANFTNPYACPDIIENLPKVMDKYGISSLEELRQEVKESLR"
     gene            15188..>15947
                     /gene="lytB"
                     /locus_tag="VXE25_002267"
     CDS             15188..>15947
                     /gene="lytB"
                     /locus_tag="VXE25_002267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010976495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endo-beta-N-acetylglucosaminidase"
                     /protein_id="HEV0772631.1"
                     /translation="MNLGEFWYNKINKNRGRRLMKKVRFIFLALLFFLASPEGAMASD
                     GTWQGKQYLKEDGSQAANEWVFDTHYQSWFYIKADANYAENEWLKQGDDYFYLKSGGY
                     MAKSEWVEDKGAFYYLDQDGKMKRNAWVGTSYVGATGAKVIEDWVYDSQYDAWFYIKA
                     DGQHAEKEWLQIKGKDYYFKSGGYLLTSQWINQAYVNASGAKVQQGWLFDKQYQSWFY
                     IKENGNYADKEWIFENGHYYYLKSGGYMAANEWIW"
BASE COUNT         4985 a         2689 c         3414 g         4859 t
ORIGIN      
        1 ataggggatt tacccactac aaatattata gagccttttt aatttctttt gggattccga
       61 ttaacattga gataacctac ctttcaattg acggtcttgt tttggttgtc acattccagt
      121 tcataaatca aaaatgtgac ggtttcattg tatatgaaac cgcttcaaaa atcaagaaaa
      181 acttgtcatc ccaatttttt tatgctagac tagtgaaaat caagttctaa tggagggaaa
      241 agtatggaat caatttttgt aaaacttgcc cagtatccgt ctatagaaac ggagcgttta
      301 ttgcttagac ctgtaacttt ggatgatgcg gaagcaatgt ttgactatgc ctcggacaag
      361 ggtaatacac gttacacttt tccaaccaat caaagcttgg aagaaaccaa gaataacatt
      421 gctcagttct acttggctaa tcccttggga cgttggggaa tagaactaaa aagcaatggc
      481 aaatttatcg gaacaattga tttgcacaag attgatcctg ttcttaagaa ggtagctatt
      541 ggttatatta tcaaccaaac gtattggaat caaggattaa cgacagaaac caatcgtgct
      601 gtgattgagc tagcttttga gaagatagga atgaataagt tagttgcttt atacgataag
      661 gctaatcccg catcaggaaa ggtcatggag aaatcaggaa tgcgtttttc ccatgcagaa
      721 ccatatgctt gtatgtacca gcatgaaaaa ggccgaatcg tgacaagagt tcattatgtc
      781 ttgaccaagg aagactattt tgcaaataaa taagcagttg aaaagaaatt tttcgactgt
      841 tttttcttcc tcttacgaat aatctaagag aggagaaaat atggaagcaa ttatcgagaa
      901 aatcaaagag tataaaatca tcgtcatctg tactggtctg ggcttgcttg taggaggatt
      961 tttcctgcta aaaccagctc cacaaacacc tgtcaaagag acgaatttgc aggctgaagt
     1021 cgcagctgtt tccaaggatt tggtatccga aaaggaagtg aacaaggaag aaaaggaaga
     1081 accccttgaa caagatctaa tcacagtaga tgtcaaaggt gctgtcaaat cgccagggat
     1141 ttatgacttg cctgtaggta gtcgagtcaa tgatgctgtt cataaggctg gtggcttgac
     1201 agagcaagca gacagcaagt cgctcaatct agctcagaaa gttagtgatg aggctctggt
     1261 ttacgttcct actaagggag aagaatcagt tagccaacag actggtttgg ggacagcttc
     1321 ttcaataagc aaggaaaaga aggtcaatct caacaaggcc agtctggaag aactcaagca
     1381 ggtcaaggga ctgggaggaa aacgagctca ggacattatc gaccatcgtg aggcaaatgg
     1441 caagttcaag tcagtagacg agctcaagaa ggtctctggc attggtggca aaacaataga
     1501 aaagcttaaa gactatgtta cagtggatta agaatttctc tattccccta atttacctga
     1561 gttttctatt actttggctt tattacgcta ttttctcagc atcttatctt gctttgttgg
     1621 gctttgtttt tctgctagtc tgtctcttta tccaatttcc gtggaaatct gctggtaaag
     1681 ttctaataat ttgcggaatc tttggatttt ggtttgtttt tcaaaattgg caacagagtc
     1741 aagtgagtca aaatttggtg gattctgttg aaagggtacg gattttacca gacactatta
     1801 aggttaacgg tgatagtcta tcctttcgtg gcaagtctaa cggtcgtgct ttccaagtct
     1861 attataaact ccagtccgag gaggagaaag aagcctttca agctttaacc gacctgcatg
     1921 agataggact agaagggaag ctttcggagc cagaagggca gagaaatttt ggtggcttta
     1981 attaccaagc ctatctgaag actcagggaa tttaccagac tctcaatatc aaaaaaatcc
     2041 agtcacttca aaagattggc agttgggata taggagaaaa cttgtccagt ttacgtcgaa
     2101 aggctgtggt ttggattaag acgcactttc cagaccctat gcgcaattac atgacaggac
     2161 tcttgctggg atatctgaac accgactttg aggagatgaa tgagctttat tccagtctag
     2221 gaattatcca cctctttgcc ctatctggca tgcaggtagg ttttttcatg aatggattta
     2281 agaaacttct cttgcgattg ggcttgaccc aagaaaagtt gaaatggctg acttatccct
     2341 tttcccttat ctatgcggga ctaactggat tttcagcatc ggttattcgc agtctcttgc
     2401 aaaagctact ggctcaacat ggggttaagg gcttggataa ttttgccttg acggtgcttg
     2461 tcctctttat tgtcatgcca aactttttct tgacagcagg aggagtcttg tcctgcgctt
     2521 atgcttttat cctgaccatg accagcaaag aaggggaggg gctcaaggct gttgctagtg
     2581 aaagtctagt catctccttg ggcatattgc ccattctatc cttctatttt gcggaatttc
     2641 aaccttggtc tatccttttg acctttgtct tttcctttct atttgacttg accttcttac
     2701 cgctcttgtc tattttattt gtcctttcct ttctctatcc agtcattcag ctgaacttta
     2761 tctttgaatg gttagagggc attattcgct tggtctcgca ggtggcaagg agaccgcttg
     2821 tctttggtca acccaacgca tggcttttaa tcttattgtt aatttccttg gctttggtct
     2881 atgatttgag gaaaaacatt aaaggattaa cagtattgag tttattgatt acaggtctct
     2941 ttttccttac caagtatcca ctggaaaatg aaatcaccat gctggatgtg gggcaaggag
     3001 aaagtatttt cctacgggat gtaactggga aaaccattct catagatgta ggtggtaagg
     3061 cagaatctta taagaaaatc gaaaaatggc aagaaaagat gacgaccagc aatgcacaga
     3121 gaagcttgat accctatctt aaaagtcgag gagtagctaa gattgaccag ctgattttga
     3181 caaatacgga agtgtgagtt ctaaaattga tacaatacaa tttaactttt ttttgaaaaa
     3241 aattccaaaa tttattttgc attgcgaata taataagtga gagcaagttg cttacttaat
     3301 aatgatgaag aggaaaatta gaatgacaac aattttttta acaagaacaa gctgcagcaa
     3361 ttgtggaaaa caaagtacat ttgaaagatt tgatagggtt tatgcggcga agactcctga
     3421 gattatttct gctattttag actgggattt ctttaagttt acttgccata actgtaacca
     3481 caaggtgcta attgattacc caacagtcgt agtagatgaa gaacaaaaaa caattattca
     3541 gtattgtgca gatggtaatg ttgatgtact ttcaatgcaa atatgctctt tgatttcaga
     3601 gggtgtcaat ctcagtgagt atagaattcg agtagtttcg gatatagagt ctttcgttga
     3661 gaaggtacag attgtttcag tagggtatga tgatagagca attgagctta tgaagtatat
     3721 gaatagtcct cttgaggatg gtgatattca gtttaactat gaacatatgg ttttcaccaa
     3781 ggttggacat gaaaactatc aatttatgtt tattaataac cagattgcag tagcatctct
     3841 cgacttttct caagaacaat atgagtacta ccttgctgat gttgaagacc tagaaactaa
     3901 cacatattac atagactcta gatgggcgga atcattcttt cgtaccagtt tggcataaaa
     3961 ttcaaaatct atttataagt ataaatggcc tgatttttgg ttaggtcatt ttttatcttc
     4021 taatttagaa aaacgtagtt aatatatata attattatgt agatttctag aaaggaggta
     4081 aaaccaatgg taagacggaa ttctaaaatt acccgtcaac agaagaaaat tcgagatgca
     4141 tttgtatctg agagaactgt tgaaattatt cctgcaaagc gagagttcac tgatgttaaa
     4201 actaagaagt tacgtgttgc tgcatattgt cgagtaagta cttttgacga atctcagtca
     4261 ggtagttttg aacttcaaaa acaaacctat actgaaagaa tcaatagtaa tcctgattgg
     4321 ataatggctg gaatctatgc tgaccaaggt gcatcaggaa catcaatcaa acgacgtgaa
     4381 caattccaac agatgcttca tgattgtaga tgtgggaaga ttgacttgat aatcgttaag
     4441 agtgttagca ggtttgctcg taatcagcta gatttcatta gtatttaccg agagttgaag
     4501 gcactatccc ctccagttgg aatatatatc gaagatataa atttgaatac acttgatacg
     4561 aatagtgaat tcattcttgg tattatggcc atagtagctc aaggtgagag tgaacaaaaa
     4621 agtgcgtcaa ttacatggtc tgtcattgaa cgctttaaaa gagggatacc aatgattcct
     4681 acccataacc ttcttgggta tacgaaagac cagtatggtc gagtagtgat agatgagaca
     4741 gaagcaaaaa ttgttcgcct aatatatgat tcgtacatcg aaggtatgac tgcaagtgag
     4801 attgcctcta ctttaatgac caatcatata ccaacagtta ctggtttgga gcgttggaca
     4861 agtttagctg tttataatat tctcagaaac gagaaatata aaggcgaaat catcatgcag
     4921 aagacatata ctgttgattg ttttagtcat aaaacacgga aaaataatgg tgaaaagcca
     4981 aaatatcgat taaaaaatgg aattccctct atcataccag aatcaagatg ggatttagta
     5041 caagaattac tcaagcaacc tagaagaaaa tcgaaatcta cttctgagat atttgtacct
     5101 aaactctaca tcaagaaact caaatctggt aagttgaggg attttgttgt acttgatcct
     5161 agttggaaat cggaagacat tcacgaagtt tttaaataag aaagaggtaa attatgcgtt
     5221 ttaaagattt taatcttgaa gttgttaatg ttgaacgtta ctcatcagat tatagcatga
     5281 cggtgaacaa gaactttgtt acatttagta aaggaattgt ccaagcttta gaatacccag
     5341 cacatgtact ggttgccttt aataaggata caaaggtaat gggtatacaa gtttgtcgtg
     5401 caaaaactag gggagcattt tctttttcaa aacctgttgg ggagcaaaaa ggtattgttc
     5461 aggtaggtca taaaacttta aaagaaacac tcttaacaat catgagtgaa tggaaatctg
     5521 ataagcgtta tagagtagag gggattcaca ttcctgaaga taaagctttt gtttttgaat
     5581 tgaaggactt tgatgaacta tctgattttc gtaaaaacga caatagatag taaggaacga
     5641 agataaaaat tattggtagg agtacaacta ttgtattcct gccattttca tatccttgca
     5701 agggggttca tgttaaaata tactgtagga ggtaactcta tgaacgataa agttacaaaa
     5761 gtcagactag cctatccttt gggagaagac ctaatctatg tattcctgaa aaatataatg
     5821 cctaccgtag attcctactg ggatgcttag gaacgaatcc actcgtggct atatgtatga
     5881 atccctcagc agctaatgag gactatagcg atcgtacaat caaccgaatt ctaaatgcta
     5941 gtaaaaaaat tatatgaaga taagctcacc gttgaattca agtcagggat tgagattgac
     6001 gaagagatat agaatattaa ccgcaattta agggctaacc ccctttggcg gtttttaatg
     6061 gattttttta atttataagt tgcttaaaat gacttattgt gttaaaatat atgataatcc
     6121 aaataagaat ttaggaggaa ccgaaactat gacagcctca atgcgtttaa gataagctgg
     6181 caataagaaa agcagaatct atacccgatg ataggctttt ttgttgtgct tatttatacg
     6241 atattgagca ttcattagtt acggtgagga tattggttat ttaactatac ctttatttaa
     6301 ctatgtcttt aatatgaatg tttccaaatt gtatgtatgc agaccaaaag ccacattgtg
     6361 gatttaggcc tgcatttttt tattgcctat aatgctattc aaaatagaaa tttaagcaaa
     6421 ataatatgca ggagataata taaatggaaa aatacaacaa ttggaaactt aagttttata
     6481 caatatgggc agggcaagca gtatcattaa tcactagtgc catcttgcaa atggcgatta
     6541 ttttttacct tacagaaaaa actggatccg cgatggtctt gtctatggct tcactattag
     6601 gttttttacc ctatgcggtc tttggacctg caattggtgt gctagtggat cgtcatgata
     6661 ggaagaagat aatgattggt gctgatttaa ttatcgcagc agctggttcg gtgcttacta
     6721 ttgttgcatt ctatatggag ctacctgtct ggatggttat gatagtattg tttatccgta
     6781 gcattggaac agcttttcac accccggctc tcaatgcggt tacgccactt ttagtaccag
     6841 aagaacagct tacgaaatgt gcaggctata gtcagtcttt gcagtctata agctatattg
     6901 ttagtccggc ggttgcagca ctcttatact ccgtttggga actaaatgct attattgcca
     6961 tcgatgtatt gggtgctgtg attgcatcta ttacggtagc aattgtacgt attcctaagc
     7021 tgggtgatcg cgtgcaaagt ttggacccaa atttcataag agaaatgcaa gaaggaatgg
     7081 ctgtactacg gcaaaataaa ggattatttg ctttattact cgttggaaca ttatatatgt
     7141 ttgtttatat gccaattaat gcactattcc ctttaattag catggattac tttaatggaa
     7201 cacctgtgca tatttctatt acggaaattt cctttgcatc tggaatgttg atagggggtc
     7261 tattattagg gttatttggg aattaccaaa agcgaatctt attaataacg gcatccattt
     7321 ttatgatggg gataagctta accatttcag gattacttcc ccaaagtgga tttttcattt
     7381 ttgtagtctg ctgtgcaata atggggcttt ctgttccgtt ttacagcggt gtgcaaacag
     7441 ctctttttca ggagaaaatt aagcctgaat atttaggacg tgtattttct ttaactggaa
     7501 gtatcatgtc tcttgctatg ccaattggat taattctttc tgcactcttt gctgatagaa
     7561 tcggtgtaaa tcattggttt ttactatcag gtactttaat tatttgcatt gcaatagttt
     7621 gcccaatgat aaatgagatt agaaaattag atttaaaata aacaatattg gagggatatt
     7681 tatgtatctt attttcatgt aattcttcct gctaaaatcg cagggttttt cctgcgtaca
     7741 agcaaatgaa agcatgcgat tatagacagg aggaaatgtt atggaattaa tattaaaagc
     7801 aaaagacatt agtgtggaat tcaaaggaca cgatgtttta gatataaatg aattagaagt
     7861 atatgattat gaccgtattg gtttagtagg agcaaatggt gcaggaaaaa gcactttatt
     7921 caaggtactt ttaggagaat taattccccc aggatgtaaa atgaatcatc tgggtgaact
     7981 tgcctatatt ccccagttgg acgaagtaac tctgcaggag gaaaaagatt ttgcgcttgt
     8041 aggcaagcta ggtgttgagc aattaaatat acagaccatg agcggtggtg aagaaacaag
     8101 gcttaaaata gcacaggcct tatcggcaca ggttcatggt attttagcgg atgaacctac
     8161 gagccattta gaccgtgaag gaattgattt tctaatagga cagctaaaat attttacagg
     8221 tgcactgtta gttattagcc atgaccgcta ttttcttgat gaaatagtag ataaaatatg
     8281 ggaactgaaa gatggcaaaa tcactgagta ttggggaaac tattctgatt atcttcgtca
     8341 gaaagaggaa gaacgtaaga gacaagctgc agaatacgaa caatttattg cggaacgtgc
     8401 tcgattggaa agggctgcgg aggaaaagcg aaaacaggct cgtaaaatag aacagaaggc
     8461 aaaaggttct tcaaagaaaa aaagtactga aggcggaggg cgtttagctc atcaaaaatc
     8521 aataggaagt aaggaaaaaa agatgcataa tgccgctaaa tccctagaga acaggattgc
     8581 ggcattagga aaagtagaag ctccggaagg cattcgcaga attcgtttca ggcaaagtaa
     8641 agcattggag ctccataatc cataccctat agtcggtgcg gaaattaata aagtatttgg
     8701 ggataaggca ctgtttgaaa atgcatcttt tcaaattccg ctaggagcaa aagtggcatt
     8761 aacgggtggt aatggaaccg gaaaaacaac tttaatccaa atgatcttaa accatgaaga
     8821 aggaatttct atttcaccta aggcaaaaat aggttacttt gcacagaatg gttacaagta
     8881 caacagtaat cagaatgtta tggagtttat gcagaaggat tgtgattaca atatatcaga
     8941 aattcgttct gtgctagcat ctatggggtt caaacagaac gatattggaa aaagcttatc
     9001 tgttttaagc ggtggagaaa ttataaaatt gttgcttgct aaaatgctca tgggtagata
     9061 taacatccta ataatggatg aacccagtaa cttccttgac ataccaagtt tagaggcttt
     9121 ggaaatacta atgaaggagt acaccggaac tatcgtgttt atcacccacg ataaacgatt
     9181 actcgaaaat gtagctgatg tagtttatga aattagagat aagaaaatta agctgaaaca
     9241 ttaaatttta ggtagtcgct ggtcagtata gtctgttctg gctggcgact ccattgttaa
     9301 agagtataaa gacttgagat tttatgaaga ttaaaaatag gaacagtaaa tcgaactgct
     9361 cctatttttc tgctaaatat gttgtagttt tcttatatgt ataatgatag attagtggat
     9421 tctcttctaa ggttcttact tcaaatatga agaagtgatc gcggttatct ctggactttt
     9481 ccttattgag gacaaagtaa ttcttacgtg aagtcgccat tgttttgagg atatcatcgg
     9541 tcaggaaggt caatggaata ttcatgttgg agtagcggta gaagtcacgt tcaaaatctt
     9601 ggtagctctc gctgtaatag tccatttgca ggtgattacg ctgaaattca agctgattca
     9661 tagagcacct cctctacaag ttcaatacta acaatgtctt tcaatttcaa attaatgtga
     9721 cctgttgtag tttttatcaa aatgaaatct ttggtcagac ttggtattgt tccagtatag
     9781 gaaacttgat tgtttttttt aacaacatga atgcgcgtgt tcagttgccc agcatacacc
     9841 tgactgagga gtaataattt cttctccagt gacaaatctg acatatacgt tactttgttt
     9901 gcatcgtcag tgagtgctga tgtatgctca gataggaaaa agcccatcca tttttgcatc
     9961 ttagtatcct ggtactctct tgctgactga aatggcaagt atgaacgatc aatcatttta
    10021 atccctccaa tccaccagcg gaatgaccgc cgataagttt actacgttca atatttctgg
    10081 aaccttcggt taggacggtt cctttttgaa tagctaaaaa gccaaactgt tctctgacaa
    10141 catcaattgc tgtctgaagt ctattttctt tttcaatttg ttctacatca tcaaaaagtg
    10201 acagtagagt aaagttttca tctacaaagc caccataaga cacaccgatt tgcctcactg
    10261 caccagaggt gtatttcttt cggaataatt caagtacatg accaaccatt gtttttggaa
    10321 gatttgctgg gtcaattttt ttctgagcat taattgattt tttcatctca gttctagaat
    10381 agccaatatg aatagaaacg acagtagctt ttttatgtgc cgagcgaaga cggttagccc
    10441 tgacttaaaa atgggggttg accgcgaacg gaagatttac caagccctgt atcccttgaa
    10501 cataaaagca catactttgg agtttccgac ccacgggatt gatcagattg tctggatttt
    10561 agaggctatc atcccaagct tgtttgtggt tgctattatt tttatgctca cgcaactgtt
    10621 tgcagaaaga tatccaaatc atctggatac agctcagtta tatccttttt caaaagtggc
    10681 atttgcttta tcctctcttg gagttggagt gggctatgta agtgtgctgt ttatcggaat
    10741 ctgtggattt tcttttctag tgggaagtct gataagtggt tttggacagt tagattatcc
    10801 ctacccaatt tatagcttag tgaatcaaga ggtaactatt ggaaagatac aagatgtgtt
    10861 atttcctggc ttgttcttag ctttcttagc ctttatcgtc attgtggaag tagtgtactt
    10921 gattgcttac tttttcaagc aaaaaatgcc tgtccttttt ctttcactca ttgggattgt
    10981 tggcttattg tttggtatcc aaacaattca gcctcttcaa aggattgcac atctgattcc
    11041 ctttacttac ttgcgttcag tggagatttt gtctggaagc ttacctaagc aaattgataa
    11101 tgtcaatctg aattggggta tggggctagt cttacttcct tgcttgatta tccttttgtt
    11161 agtggggatt ctatttattg aaagctgggg aagttcacgt aaaaaggaag tttttaatag
    11221 gtcttagcat tcttataagg aagttaagga aaaactaaca tagagaggga atcaacttga
    11281 ttctctcttt ttgattcgaa aaccaaacca aaatacaaac acaaactttt caaaaaaata
    11341 actttttatc ttgacaagag ctagaaaact tggtatcatt taaaagttga gaaaagcaga
    11401 agtgagagct tctcgccttg tgacattaag ttgcctggcc ctacggatga aaagtttcga
    11461 agaaacgcta tcataacgtg cgggcttgta tatttacgag tccgctattg tttttctcta
    11521 ataaaacaaa agaggtgaaa accatagcaa agcaagactt attcatcaat gatgagattc
    11581 gtgtacgtga agttcgcttg attggtcttg agggagaaca gctaggcatc aagccactca
    11641 gtgaagcgca agctttggct gataacgcta atgttgacct agtattgatt caaccccaag
    11701 ccaaaccgcc tgttgcaaaa attatggact acggtaagtt caaatttgag taccagaaga
    11761 agcaaaaaga acaacgtaaa aaacaaagcg ttgttactgt gaaagaagtt cgtctaagtc
    11821 caacaattga caagggtgac tttgatacaa aacttcgtaa tgcacgtaag ttccttgaaa
    11881 aaggaaataa agttaaggta tctattcgct ttaagggtcg tatgattacc cataaagaga
    11941 ttggtgcaaa agttttagcc gagtttgctg aagcaactca agatattgcc atcatcgaac
    12001 aacgtgctaa aatggatgga cgtcaaatgt tcatgcaatt ggcgccagcg actgacaaaa
    12061 aataattgtc agaaagttaa ataaaggaga aaaaatcatg ccaaaacaaa aaacacaccg
    12121 cgcatcagct aaacgtttca aacgtacagg ttctggtgga cttaaacgtt tccgtgctta
    12181 cacttctcac cgtttccacg gaaaaactaa gaaacaacgt cgtcatcttc gtaaagcatc
    12241 tatggtgcat tcaggagatt acaaacgtat caaagcaatg cttactcgct tgaaataata
    12301 gcttgactgt aagtaaacaa ttctaggaaa tatttggagg aaataaaaca tggcacgtgt
    12361 taaaggtggc gttgtatcac gcaaacgtcg taaacgtatt cttaaattag caaaaggtta
    12421 ctatggagct aaacacatct tgttccgtac tgcaaaagaa caagtaatga actcttacta
    12481 ctatgcatac cgtgaccgtc gtcagaaaaa acgtgacttc cgcaaattgt ggattactcg
    12541 tatcaatgcg gcagctcgta tgaacggact ttcatactca caattgatgc atggtttgaa
    12601 attggctgag atcgaagtta accgtaaaat gcttgctgac ttggctgtta acgatgcagt
    12661 agctttcaca gctcttgcag atgcagctaa agcaaaactt ggtaaataac aactgatgag
    12721 actggaacag gattgtccag tctttttaaa aataaaggag aaagatatgg cttcaaaaat
    12781 gctacacact tgcttacgag tagaaaatct tgaaaaatca atcgcatttt atcaagatgc
    12841 ttttggtttt aaagaattgc gtcgcagaga ttttccagac catgccttca cgattgtcta
    12901 tctaggtctt gagggtgatg attatgagtt ggagttgact tataactacg atcacggtcc
    12961 gtatgtggtt ggtgatgggt ttgcccatat cgccctcagt acacctgatc ttgaggcact
    13021 tcatcaagaa cacagtgcaa aaggctatga agtgactgag ccaaatggtc taccaggaac
    13081 tacaccaaac tattactttg tcaaagaccc tgatggatat aaggtcgaag tcattcgtga
    13141 aaaataattt cgtgcaagtt aagtagaata ttcgttttct acttgacttt ttttagctga
    13201 aagagtatac taataaaaat tcaaccttta aggggagtcc agagagactc acaaggtgtc
    13261 agataaaaga atagtgcaat tttctagagg agactttttg agtgtgctct cttgtgttgt
    13321 acgattttaa ctgaggcctt gcactagcaa ggtcttttct ttatctggtc cccttaaaat
    13381 ttaaggagga aaagttatga atcccacatg taagaagcgt ttgggtgtca ttcggttgga
    13441 aaccatgaag gtggttgcac aagaggaaat cgcgccagca atctttgaat tagtcctaga
    13501 aggagaaatg gttgaagcca tgcgagcagg ccaatttctt catctgcgtg taccagacga
    13561 tgcccatctt ttacgtcgtc ctatttcaat ttcgtctatt gacaaggcaa acaagcagtg
    13621 tcacctcatt tatcggattg agggagctgg gactgcaatt ttttcaacct taagtcaggg
    13681 agacactctt gatgtgatgg ggcctcaggg aaatggtttt gacttgtctg accttgatga
    13741 gcagaatcag gttctccttg ttggtggtgg gattggtgtt ccacccttgc ttgaggtggc
    13801 caaggaattg catgaacgtg gagtgaaagt agtgacagtc ctcggttttg ctaataagga
    13861 tgctgttatt ttgaaaacgg aattggctca gtatggtcag gtctttgtaa cgacagatga
    13921 tggttcttat ggcatcaagg gaaatgtttc cgttgttatc aatgatttag atagtcagtt
    13981 tgatgctgtt tactcgtgtg gggctccagg aatgatgaag tatatcaatc aaacctttga
    14041 tgatcaccca agagcctatt tatctctgga atctcgtatg gcttgtggga tgggagcttg
    14101 ctatgcctgt gttctaaaag taccagaaag cgagacggtc agccaacgcg tctgtgaaga
    14161 tggtcctgtt ttccgcacag gaacagttgt attataagga gaaaattatg actacaaatc
    14221 gattacaagt gtctctacct ggtttggatt tgaaaaatcc gattattcca gcatcaggtt
    14281 gttttggttt tggacaagag tatgccaagt actatgattt aaacctttta ggttctatta
    14341 tgatcaaggc gacaaccctt gaaccacgtt ttggaaatcc aactccaaga gtggcagaga
    14401 cgcctgctgg tatgctcaat gcaattggct tgcaaaatcc tggtttagag gttgttttgg
    14461 ctgaaaagct accttggctg gaaagagaat atccaaatct tcctattatt gccaatgtag
    14521 ctggtttttc aaaacaagag tatgcagctg tttctcatgg gatttccaag gcaactaatg
    14581 taaaagctat cgagctcaat atttcttgtc ccaatgttga ccactgtaat catggacttt
    14641 tgattggtca agatccagat ttggcttatg atgtggtgaa agcagctgtg gaagcctcag
    14701 aagtgccagt ttatgtcaaa ttaaccccga gtgtgaccga tatcgttact gtcgcaaaag
    14761 ctgcagaaga tgcgggagca agtggcttga ccatgatcaa tactctggtt ggaatgcgct
    14821 ttgacctcaa aaccagaaaa ccaatcttgg ccaatggaac aggtggaatg tcaggtccag
    14881 cagtctttcc agtagccctc aaactcatcc gccaagtagc ccaaacaaca gacctgccta
    14941 tcattggaat ggggggagtg gattcggctg aagctgccct agaaatgtat ctggctgggg
    15001 catctgctat cggagttgga acagctaact ttaccaatcc ttatgcctgc cctgacatca
    15061 tcgaaaattt accaaaagtc atggataaat acggtattag cagtctggaa gaactccgtc
    15121 aggaagtaaa agagtctctg aggtaaacta caatcaatct gttcttgatt ttttattagt
    15181 ttgtaatatg aatttaggag aattttggta caataaaata aataagaaca gaggaagaag
    15241 gttaatgaag aaagtaagat ttattttttt agctctgcta tttttcttag ctagtccaga
    15301 gggtgcaatg gctagtgatg gtacttggca aggaaaacag tatctgaaag aagatggcag
    15361 tcaagcagcg aatgagtggg tttttgatac tcattatcaa tcttggttct atataaaagc
    15421 agatgctaac tatgctgaaa atgaatggct aaagcaaggt gacgactatt tttacctcaa
    15481 atctggtggc tatatggcca aatcagaatg ggtagaagac aagggagcct tttattatct
    15541 tgaccaagat ggaaagatga aaagaaatgc ttgggtagga acttcctatg ttggtgcaac
    15601 aggtgccaaa gtaatagaag actgggtcta tgattctcaa tacgatgctt ggttttatat
    15661 caaagcagat ggacagcacg cagagaaaga atggctccaa attaaaggga aggactatta
    15721 tttcaaatcc ggtggttatc tactgacaag tcagtggatt aatcaagctt atgtgaatgc
    15781 tagtggtgcc aaagtacagc aaggttggct ttttgacaaa caataccaat cttggtttta
    15841 catcaaagaa aatggaaact atgctgataa agaatggatt ttcgagaatg gtcactatta
    15901 ttatctaaaa tccggtggct acatggcagc caatgaatgg atttggg
//
